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See detailVariations at different spatial scales of Posidonia oceanica (L.) Delile beds; effects on the physico-chemical parameters of the sediment
Gobert, Sylvie ULiege; Kyramarios, Michael; Lepoint, Gilles ULiege et al

in Oceanologica Acta (2003), 26(2), 199-207

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level ... [more ▼]

The biometric parameters (shoot density, length and width of leaves, leaf and epiphyte biomasses, leaf surface) of the P. oceanica meadow present a significant spatial variability at the mesoscale level (100 m2). All the parameters studied, excepting the number of leaves, decrease according to the depth. The horizontal spatial variations (centrifuge and centripetal distributions) reach a maximum in the shallower areas. The analysis of the microstructures (m2) of the meadow has not allowed a relationship to be established between the spatial variations of the biometric parameters and the environmental factors in the sediment (pH, water and organic matter content, red-ox potential, nutrient content). The heterogeneity of the meadow in the Revellata Bay quite probably results from the internal shoot and rhyzome growth dynamics. <br />On the other hand, it appears that the presence of the prairie modifies the physical-chemical characteristics of the sediment. In fact, the sandy patches present different physical-chemical characteristics: lower organic matter, different granulometric and much higher interstitial water nutrient levels, as well as a higher pH and oxydo-reduction potential. [less ▲]

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See detailAnimal welfare: The contribution of ethology
Vandenheede, Marc ULiege

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 17-22

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on ... [more ▼]

During the last fifty years, intensive husbandry has profoundly modified the animal living conditions, especially in pigs and poultry. At the same time, concerns about animal welfare were growing on. "Welfare " (" le bien-etre " in french) can be defined as a state of dynamic balance (homeostasy) between the animal and its environment (internal and external). The attempts of the animal to maintain or to adjust this balance may induce physical and mental sufferings, eventually harmful even on a health than on a performance point of view. Welfare of farm animals is assessed using 4 complementary and closely linked types of measures, i.e. performance, health, physiology and ethology. Ethological measurements involve a lot of advantages and are more and more utilised: study of adaptation abilities, behavioural disorders or animal motivation and preference. Ethology is thus considered as a very useful tool that can not be neglected, as shown by the important scientific work, notably in pigs and poultry. Research results have to constitute an essential prerequisite to the ethical reflection process regarding animal welfare, allowing to induce concrete and relevant political acts. [less ▲]

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULiege et al

in Crop Science (2003), 43(6), 1999-2005

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See detailVTT benchmark: Application of the restoring force surface method
Kerschen, Gaëtan ULiege; Lenaerts, V.; Golinval, Jean-Claude ULiege

in Mechanical Systems & Signal Processing (2003), 17(1), 189-193

The restoring force surface method is an efficient and reliable technique for the identification of non-linear mechanical systems. The objective of this paper is to demonstrate its utility for the ... [more ▼]

The restoring force surface method is an efficient and reliable technique for the identification of non-linear mechanical systems. The objective of this paper is to demonstrate its utility for the identification of the VTT benchmark. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailEffect of low-dose perindopril/indapamide on albuminuria in diabetes: preterax in albuminuria regression: PREMIER.
Mogensen, Carl Erik; Viberti, Giancarlo; Halimi, Serge et al

in Hypertension (2003), 41(5), 1063-71

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril ... [more ▼]

Microalbuminuria in diabetes is a risk factor for early death and an indicator for aggressive blood pressure (BP) lowering. We compared a combination of 2 mg perindopril/0.625 mg indapamide with enalapril monotherapy on albumin excretion rate (AER) in patients with type 2 diabetes, albuminuria, and hypertension in a 12-month, randomized, double-blind, parallel-group international multicenter study. Four hundred eighty-one patients with type 2 diabetes and hypertension (systolic BP > or =140 mm Hg, <180 mm Hg, diastolic BP <110 mm Hg) were randomly assigned (age 59+/-9 years, 77% previously treated for hypertension). Results from 457 patients (intention-to-treat analysis) were available. After a 4-week placebo period, patients with albuminuria >20 and <500 microg/min were randomly assigned to a combination of 2 mg perindopril/0.625 mg indapamide or to 10 mg daily enalapril. After week 12, doses were adjusted on the basis of BP to a maximum of 8 mg perindopril/2.5 mg indapamide or 40 mg enalapril. The main outcome measures were overnight AER and supine BP. Both treatments reduced BP. Perindopril/indapamide treatment resulted in a statistically significant higher fall in both BP (-3.0 [95% CI -5.6, -0.4], P=0.012; systolic BP -1.5 [95% CI -3.0, -0.1] diastolic BP P=0.019) and AER -42% (95% CI -50%, -33%) versus -27% (95% CI -37%, -16%) with enalapril. The greater AER reduction remained significant after adjustment for mean BP. Adverse events were similar in the 2 groups. Thus, first-line treatment with low-dose combination perindopril/indapamide induces a greater decrease in albuminuria than enalapril, partially independent of BP reduction. A BP-independent effect of the combination may increase renal protection. [less ▲]

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See detailInteraction Of Surfactin With Membranes: A Computational Approach
Deleu, Magali ULiege; Bouffioux, O.; Razafindralambo, Hary ULiege et al

in Langmuir (2003), 19(8),

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See detailChoice of an adjuvant for vaccination trials
Vermout, Sandy; Denis, M.; Losson, Bertrand ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6), 393-401

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it ... [more ▼]

The development of new vaccines, containing protective antigens that are more and more well characterized, is hindered by the lack of adjuvants able both to amplify immune response and to control it qualitatively. A number of tumors and infectious diseases could be treated with adjuvant preparations that would adequately intensify and modulate specific immune response; in particular, the possibility to specifically induce a Th1 response seems to be of paramount importance for the prevention and for the cure of these diseases. Furthermore, these adjuvants must be as safe as possible, not only for commercial applications, but also in the respect of laboratory animals' welfare. This review describes the different adjuvants presently used in vaccinology, classifying them following their chemical nature and presenting for each category the knowledge concerning their activity and toxicity. [less ▲]

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See detailToxicomanes: sevrage ultrarapide aux opiacés sous anesthésie générale au CHU de Liège
Pinto, Emmanuel ULiege; Reggers, Jean ULiege; Fuchs, S. et al

in Agenda Psychiatrie (L') (2003), 28

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See detailTowards an Understanding of Hafting: the macro- and microscopic evidence
Rots, Veerle ULiege

in Antiquity (2003), 77(298), 805-815

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See detailUn acte de mécénat d'Aubert Le Mire (1573-1640) en faveur des Dominicains de Bruxelles
Adam, Renaud ULiege

in Revue du Cercle d'Histoire de Bruxelles et Extensions (2003), 79

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See detailCharacterization of UDP-glucose : protein transglucosylase genes from potato.
Wald, F. A.; Kissen, R.; du Jardin, Patrick ULiege et al

in Plant Molecular Biology (2003), 52

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See detailL'urticaire et ses implications systémiques
Dezfoulian, Bita ULiege; Khalil, Z.; de LA BRASSINNE, Michel ULiege

in Revue Médicale de Liège (2003), 58(12), 751-756

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several ... [more ▼]

Urticaria is a transient eruption of erythematous or oedematous swelling of the dermis and is usually associated with itching which clinically is very easy to diagnose. However, it causes several etiological, pathophysiological and therapeutic problems. We will develop the acute and chronic urticaria as well as their different associations with systemic diseases. Some current data concerning chronic idiopathic autoimmune urticaria is reviewed. The management and therapeutics will be discussed. [less ▲]

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See detailInduction of potato (Solanum tuberosum L.) tuber sprouting by hydrogen peroxide.
Bajji, M.; M'Hamdi, M.; Gastiny, F. et al

in Free Radical Research (2003), 37

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See detailEvaluation of false transrectal ultrasonographic pregnancy diagnoses in sheep by measuring the plasma level of pregnancy-associated glycoproteins
Karen, A.; Beckers, Jean-François ULiege; Sulon, Joseph ULiege et al

in Reproduction Nutrition Development (2003), 43(6, NOV-DEC), 577-586

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy ... [more ▼]

The present study was undertaken to investigate to what extent pregnancy diagnoses made by transrectal ultrasonography could be confirmed by measurements of plasma concentration of ovine pregnancy-associated glycoproteins (ovPAG). A total of 424 Awassi x Merino ewes were synchronized for estrus and examined by transrectal ultrasonography. In Experiment 1, the ewes (n = 156) were repeatedly scanned in a standing position on d 29, 36 and 50 of gestation. Similarly, the ewes (n = 268) in Experiment 2 were scanned on d 24, 29 and 34 of gestation, but these ewes were fasted for 12 h prior to the examination and the abdominal wall of each animal was lifted up by the hands of the assistant during the scanning. Blood samples were withdrawn after each transrectal ultrasonographic examination in both experiments. Ovine PAG concentrations were measured in plasma by a heterologous radioimmunoassay and the cut-off value for pregnancy was greater than or equal to 1 ng.mL(-1). Based on the lambing performance, in Experiment 1, altogether 47 false negative and 38 false positive diagnoses were made by transrectal ultrasonography in 24 and 33 ewes, respectively between d 29 and 50 of gestation. In Experiment 2, altogether 8 false negative and 13 false positive diagnoses both were made in 7 ewes between d 24 and 34 of gestation. In both experiments, all ewes with false negative diagnoses had ovPAG concentrations higher than the threshold level for pregnancy diagnosis and all ewes with false positive diagnoses had ovPAG concentrations lower than the threshold of pregnancy. Furthermore, by the PAG-RIA test all lambed or aborted ewes (n = 63) were correctly diagnosed as pregnant and with three exceptions, all non-lambed ewes (n = 361) were correctly diagnosed as non-pregnant during the examined periods of both experiments. [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 4- Synopsis des armes nucléaires.
Pierard, Gérald ULiege

in FALCO (2003), Fevrier

The nuclear weapons have a terrifying power of devastation. A civilan nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences ... [more ▼]

The nuclear weapons have a terrifying power of devastation. A civilan nuclear accident has its own dramatic consequences. Both situations are, however, totally distinct with regard to medical consequences. The Gulf war and Balkan war syndromes might be in part caused by uranium used in conventional amunitions. Th erisk of nuclear terrorism is an emerging eventuality. [less ▲]

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See detailLa maladie du hêtre en Région wallonne : état des lieux chiffré de 2001 à 2003
Rondeux, Jacques ULiege; Huart, O.; Lecomte, H. et al

in Silva Belgica (2003), 110(3), 18-28

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See detailDual approach using a variant perimeter constraint and efficient sub-iteration scheme for topology optimization
Zhang, Weihong; Duysinx, Pierre ULiege

in Computers & Structures (2003), 81(22-23), 2173-2181

To prevent numerical instabilities associated with the mesh-dependence, checkerboards and grey regions in topology optimization, a variant perimeter-constrained version of the SIMP algorithm is proposed ... [more ▼]

To prevent numerical instabilities associated with the mesh-dependence, checkerboards and grey regions in topology optimization, a variant perimeter-constrained version of the SIMP algorithm is proposed using a smooth and quadratic function. In order to have an efficient implementation and to make sure the strict satisfaction of such an upper-bound perimeter constraint, a diagonal quadratic approximation of the perimeter constraint is used in the construction of each explicit optimization subproblem. The latter is then solved by a dual sub-iteration scheme. Numerical results show that the incorporation of such a sub-iteration scheme leads to a convergent solution without needs of move-limits or artificial control parameters. In addition to this, it is found that successive relaxations of the perimeter constraint by increasing the upper-bound tend to regularize the topology solution and result in a checkerboard free and satisfactory design solution without grey regions. [less ▲]

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See detailEinstein oscillators in thallium filled antimony skutterudites
Hermann, Raphaël ULiege; Jin, R. J.; Schweika, W. et al

in Physical Review Letters (2003), 90(13),

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 ... [more ▼]

Inelastic neutron scattering measurements on several Tl filled skutterudites (Tl0.5Co3.5Fe0.5Sb12, Tl0.8Co3FeSb12, and Tl0.8Co4Sb11Sn) all show a sharp peak in the vibrational density of states at 57 +/- 2 K, which is absent in the unfilled skutterudite CoSb3. Heat capacity measurements on Tl0.8Co4Sb11Sn as compared to CoSb3 are consistent with the presence of a localized vibrational mode associated with the "rattling" thallium atoms in this filled skutterudite compound. Both results are well described by a localized Einstein mode model with an Einstein temperature Theta(E) of 53 +/- 1 K. These data provide perhaps the clearest example of local mode behavior in a concentrated metallic system. [less ▲]

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See detailCognitive impairment, dementia and quality of life.
Kurz, Xavier; Scuvée-Moreau, Jacqueline ULiege; Vernooij-Dassen, M. et al

in Acta Neurologica Belgica (2003), 103

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See detailDiagnostic différentiel des troubles à expression nerveuse dans l’espèce bovine en Europe occidentale
Saegerman, Claude ULiege; Claes, L.; Dewaele, A. et al

in Revue Scientifique et Technique (International Office of Epizootics) (2003), 22(1), 61-82

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See detailModulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.
Liégeois, Jean-François ULiege; Mercier, Frédéric ULiege; Graulich, Amaury et al

in Current Medicinal Chemistry (2003), 10(8), 625-47

Small conductance calcium-activated potassium (SK) channels are found in many types of neurons as well as in some other cell types. These channels are selective for K(+) and open when intracellular Ca(2 ... [more ▼]

Small conductance calcium-activated potassium (SK) channels are found in many types of neurons as well as in some other cell types. These channels are selective for K(+) and open when intracellular Ca(2+) rises to omega 500 nM. In neurons, this occurs during and after an action potential. Activation of SK channels hyperpolarizes the membrane, thus reducing cell excitability for several tens or hundreds of milliseconds. This phenomenon is called a afterhyperpolarization (AHP). Three subtypes of SK channels (SK1, SK2, SK3) have been cloned and exhibit a differential localization in the brain. SK channels may play a role in physiological and pathological conditions. They may be involved in the control of memory and cognition. Moreover, they are heavily expressed in the basal ganglia (in particular in the substantia nigra, pars compacta) and in the limbic system, suggesting that they may modulate motricity and emotional behaviour. Based on these facts, SK channel subtypes may be a suitable target for developing novel therapeutic agents, but more work is needed to validate these targets. Hence, there is a great need for selective ligands. Moreover, although the risk of peripheral side-effects for SK channel modulators appears to be low, some questions remain to be investigated. Currently, different molecules are known as SK channel modulators. Apamin is a very potent peptidic agent; it produces a strong blockade of these targets which is only very slowly reversible and it has limited selectivity. Dequalinium was found to be an effective blocker. Different chemical modulations on the dequalinium structure led to the discovery of highly potent bis-quinolinium derivatives such as UCL 1684. Other bis-(2-amino-benzimidazole) derivatives are in development. On the other hand, quaternary salts of bicuculline were reported to be effective in inhibiting AHPs. More recent developments on structurally-related molecules revealed that methyl-laudanosine is a new interesting tool for exploring SK channel pharmacology. Finally, a family of compounds has been shown to facilitate SK channel opening. Such compounds may be useful in treating disorders involving neuronal hyperexcitability. [less ▲]

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See detailModélisation 3D d’un groupe de pieux pour le pont-canal de Houdeng
Trevisan, Stefano; Li, Xian Ling; Collin, Frédéric ULiege et al

in Revue Française de Géotechnique (2003), 105

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group ... [more ▼]

A satisfactory prediction of the settlements of hyperstatic structures is becoming more and more important in their design and construction. In this paper, the problems related to the behaviour of a group of piles and to the quality of the drilled piles of the canal-bridge of Houdeng (Belgium) are analysed in a non conventional fashion, based on a finite element analysis, thanks to sufficient experimental data. The influence of an imperfectly cleaned excavation bottom and of the destructuration of the bottom rocks caused by the drilling of the piles is investigated. A particular attention is also given to the behaviour of a group of piles. [less ▲]

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See detailEtudes des impacts hydrauliques, sédimentologiques et écologiques liés aux travaux hydrauliques sur la Semois
Gob, Frédéric; Houbrechts, Geoffrey ULiege; Mols, Julien et al

in Belgeo (2003), 3

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux ... [more ▼]

Cette étude tente d’évaluer les impacts des dragages réalisés dans le bassin de la Semois (Ardenne). Cette étude interdisciplinaire se penche sur les aspects hydrauliques, environnementaux, géomorphologiques et sédimentologiques. [less ▲]

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See detailObservations sous Anvers, 12 septembre 2002
Boularbah, Hakim ULiege; Marquette, V.

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (2003)

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See detailImproved rank-based dependence measures for categorical data
Vandenhende, François; Lambert, Philippe ULiege

in Statistics & Probability Letters (2003), 63

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for ... [more ▼]

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for dependence models using copulas. [less ▲]

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See detailA stepwise approach for chemical risks assessment at the workplace
Mairiaux, Philippe ULiege; Balsat, Alain; Dujardin, Marco et al

Scientific journal (2003)

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See detailTopical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo.
Humbert, Philippe G; Haftek, Marek; Creidi, Pierre et al

in Experimental Dermatology (2003), 12(3), 237-44

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this ... [more ▼]

Vitamin C is known for its antioxidant potential and activity in the collagen biosynthetic pathway. Photoprotective properties of topically applied vitamin C have also been demonstrated, placing this molecule as a potential candidate for use in the prevention and treatment of skin ageing. A topically applied cream containing 5% vitamin C and its excipient were tested on healthy female volunteers presenting with photoaged skin on their low-neck and arms in view to evaluate efficacy and safety of such treatment. A double-blind, randomized trial was performed over a 6-month period, comparing the action of the vitamin C cream vs. excipient on photoaged skin. Clinical assessments included evaluation at the beginning and after 3 and 6 months of daily treatment. They were performed by the investigator and compared with the volunteer self assessment. Skin relief parameters were determined on silicone rubber replicas performed at the same time-points. Cutaneous biopsies were obtained at the end of the trial and investigated using immunohistochemistry and electron microscopy. Clinical examination by a dermatologist as well as self-assessment by the volunteers disclosed a significant improvement, in terms of the 'global score', on the vitamin C-treated side compared with the control. A highly significant increase in the density of skin microrelief and a decrease of the deep furrows were demonstrated. Ultrastructural evidence of the elastic tissue repair was also obtained and well corroborated the favorable results of the clinical and skin surface examinations. Topical application of 5% vitamin C cream was an effective and well-tolerated treatment. It led to a clinically apparent improvement of the photodamaged skin and induced modifications of skin relief and ultrastructure, suggesting a positive influence of topical vitamin C on parameters characteristic for sun-induced skin ageing. [less ▲]

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See detailAmélioration de la détection d’une maladie émergente : exemple de l’ encépahlopathie spongiforme bovine
Saegerman, Claude ULiege; Berkvens, D.; Speybroeck, N. et al

in Epidémiologie et Santé Animale (2003), 44

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See detailLa possible modification de la procédure de révision de la Constitution belge
Behrendt, Christian ULiege

in Revue Française de Droit Constitutionnel (2003)

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new ... [more ▼]

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new amendment procedure. [less ▲]

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See detailFeasibility and reproducibility of off-line tissue Doppler measurement of regional myocardial function during dobutamine stress echocardiography.
Fraser, A. G.; Payne, N.; Madler, C. F. et al

in European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology (2003), 4(1), 43-53

AIMS: Off-line post-processing of colour tissue Doppler from digital loops may allow objective quantification of dobutamine stress echocardiography. We assessed the reproducibility of off-line ... [more ▼]

AIMS: Off-line post-processing of colour tissue Doppler from digital loops may allow objective quantification of dobutamine stress echocardiography. We assessed the reproducibility of off-line measurements of regional myocardial velocities. METHODS AND RESULTS: Nine observers analysed 10 studies, each making 2400 observations. Coefficients of variation in basal segments from apical windows, at rest and maximal stress, were 9-14% and 11-18% for peak systolic velocity, 16-18% and 17-19% for time-to-peak systolic velocity, 9-17% and 18-24% for systolic velocity time integral, and 18-23% and 21-27% for systolic acceleration. Coefficients of variation for diastolic velocities in basal segments at rest were 11-40%. Coefficients of variation for peak systolic velocity were 10-24% at rest and 14-28% at peak in mid segments, and 19-53% and 29-69% in apical segments. From parasternal windows coefficients of variation for peak systolic velocity were 14-16% in basal posterior, and 19-29% in mid-anterior segments. High variability makes measurement unreliable in apical and basal anterior septal segments. The feasibility of obtaining traces was tested in 92 subjects, and >90% in all basal and mid segments apart from the anterior septum. CONCLUSION: Quantification of myocardial functional reserve by off-line analysis of colour tissue Doppler acquired during dobutamine stress is feasible and reproducible in 11 segments of the left ventricle. The most reliable measurements are systolic velocities of longitudinal motion in basal segments. [less ▲]

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See detailImbalance between lipoxin A(4) and leukotriene B-4 in chronic mastitis-affected cows
Boutet, Philippe ULiege; Bureau, Fabrice ULiege; Degand, Guy ULiege et al

in Journal of Dairy Science (2003), 86(11), 3430-3439

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a ... [more ▼]

Persistent accumulation of inflammatory cells in the udder, with neutrophils being the predominant cell type, is a characteristic feature of chronic mastitis in dairy cows. Leukotriene (LT) B-4 is a potent chemotactic agent, known to induce recruitment and accumulation of neutrophils in the bovine mammary gland. The LTB4-stimulated neutrophil functional responses are closely opposed by lipoxin (LX) A(4), which promotes the resolution of inflammation. We thus hypothesized that the chronic inflammation of the udder could be associated with an unfavorable ratio between these two eicosanoids and that the persistence of neutrophil accumulation could be due to an increase in LTB4 synthesis and/or an impaired LXA(4) production. In an attempt to verify this hypothesis, we first measured LXA(4), LTB4, and their ratio in the milk of healthy and acute and chronic mastitis-affected quarters. Next, we studied the relationships between these variables and the degree of udder inflammation as assessed by somatic cell count measurement. The LTB4 concentration was low in healthy quarters, drastically increased in acute mastitis, and reached intermediate levels in chronic mastitis-affected quarters. However, whereas LXA(4) concentration was highly increased in acute mastitis, healthy and chronic quarters had similarly low values. The LXA(4):LTB4 ratio was thus significantly lower in chronic mastitis-affected cows. The LTB4 concentrations measured in chronic quarters were highly correlated to somatic cell count and to milk neutrophil and macrophage numbers. A weaker correlation was observed between LXA(4) and these variables. For both eicosanoids, the highest correlation was observed with the number of neutrophils. These results show the existence of an LXA(4):LTB4 imbalance in chronic mastitis-affected cows because of low LXA(4) concentrations. Further studies are needed to determine whether administration of LX or stable analogs could have therapeutic potential in the control of chronic bovine mastitis. [less ▲]

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See detailDifference in risk factors for postoperative nausea and vomiting.
Stadler, Michaela; Bardiau, Françoise ULiege; Seidel, Laurence ULiege et al

in Anesthesiology (2003), 98(1), 46-52

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for ... [more ▼]

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for postoperative nausea and vomiting in various surgical populations in a clinical audit setting. METHODS: The study included 671 consecutive surgical inpatients, aged 15 yr or more, undergoing various procedures. The study focused on postoperative nausea visual analog scale scores every 4 h and vomiting episodes within 72 h. Both vomiting and retching were considered as emetic events. Patient-, anesthesia-, and surgery-related variables that were considered to have a possible effect on the proportion of patients experiencing postoperative nausea and/or vomiting were examined. The bivariate Dale model for binary correlated outcomes was used to identify selectively the potential risk factors of postoperative nausea and vomiting. RESULTS: Among the 671 patients in the study, 126 (19%) reported one or more episodes of nausea, and 66 patients (10%) suffered one or more emetic episodes during the studied period. There was a highly significant association between the two outcomes. Some risk factors were predictive of both nausea and vomiting (female gender, nonsmoking status, and general anesthesia). History of migraine and type of surgery were mainly responsible for nausea but not for vomiting. The predictive effect of risk factors was controlled for postoperative pain and analgesic drugs. CONCLUSION: This study shows that differences exist in risk factors of postoperative nausea and vomiting. These could be explained by differences in the physiopathology of the two symptoms. [less ▲]

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See detailBiogeographical Observations On Four Scolytids (Coleoptera, Scolytidae) And One Lymexylonid (Coleoptera, Lymexylonidae) In Wallonia (Southern Belgium)
Henin, Jm.; Huart, O.; Rondeux, Jacques ULiege

in Belgian Journal of Zoology (2003), 133(2), 175-180

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999 ... [more ▼]

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999. Consequently, the ambrosia beetles Trypodendron domesticum L. and T. signatum (Fabricius) (Coleoptera, Scolytidae) initiated outbreaks and, in 2000 and 2001, they heavily contributed to the depreciation of nearly 1,600,000 m3 of stem volume (to upper limit girth of 22 cm) in the natural regions of “Ardenne” and “Belgian Lorraine”. Because of the lack of biogeographical data on both insects, of their conspicuous aggressiveness towards apparently healthy trees and of the economic importance of the beech wood chain in Belgium, a large-scale survey was undertaken in 2001, in order to outline the range of both ambrosia beetles in Wallonia. To this effect, a network of 172 traps baited with ethanol was set up, attempting to cover the Walloon beech forest as representatively as possible. Two other scolytids and one lymexylonid were also frequently caught, which made it possible to outline their regional distribution too. Although the damage was limited to the Ardenne and Belgian Lorraine, T. domesticum and T. signatum are widespread throughout Wallonia. We discuss these results, their long-term validity, the secondary pest status of these insects and the need for a permanent monitoring of the major forest pest species and diseases. [less ▲]

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See detailFaillite de l'imaginaire, la dermatite atopique ?
Dracoulis, H.; Gauthier, Jean-Marie ULiege

in Revue Française de Psychiatrie et de Psychologie Médicale (2003), 7(66), 51-56

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See detailLa figure de la Vierge Marie dans l’histoire des femmes et du féminisme
Delfosse, Annick ULiege

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2003), 8

The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed ... [more ▼]

The A. offers to study the place of the Marian figure in the women story. She proves to show various points of view: the masculine cleric authorities’ use of the Virgin as an identification norm imposed to the women as well as the claim of these latter to define the Virgin also as an emancipation tool. [less ▲]

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See detailAlong or across front ocean survey strategy? The estimation of quasi-geostrophic vertical velocities and temperature fluxes
Rixen, Michel; Allen, J. T.; Pollard, R. T. et al

in Geophysical Research Letters (2003), 30(5), 61-68

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio ... [more ▼]

In a companion paper we have shown that at the mesoscale, the unusual across front sampling strategy (AL) is more accurate than the usual across front sampling strategy (AC) on hydrographic and bio-chemical properties when the front is sufficiently developed. The cruise design based on the optimal reconstruction of the density fields does however not imply that derived variables like quasi-geostrophic (QG) vertical velocities and temperature fluxes also exhibit minimal associated errors. Here we present results of optimized sampling strategies for diagnostic QG vertical velocities (wQG) and temperature fluxes (θQG) derived from the omega equation. Results are illustrated in the same framework, for the Iceland-Faroes oceanic frontal area and for a control model and reveal that at these spatio-temporal scales, the unusual AL may also provide better estimations of vertical velocities and temperature fluxes compared to the classic AC, especially when the front is sufficiently developed. [less ▲]

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See detailInterlaboratory study of a liquid chromatography method for erythromycin: determination of uncertainty.
Dehouck, P.; Vander Heyden, Y.; Smeyers-Verbeke, J. et al

in Journal of Chromatography. A (2003), 1010(1), 63-74

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been ... [more ▼]

Erythromycin is a mixture of macrolide antibiotics produced by Saccharopolyspora erythreas during fermentation. A new method for the analysis of erythromycin by liquid chromatography has previously been developed. It makes use of an Astec C18 polymeric column. After validation in one laboratory, the method was now validated in an interlaboratory study. Validation studies are commonly used to test the fitness of the analytical method prior to its use for routine quality testing. The data derived in the interlaboratory study can be used to make an uncertainty statement as well. The relationship between validation and uncertainty statement is not clear for many analysts and there is a need to show how the existing data, derived during validation, can be used in practice. Eight laboratories participated in this interlaboratory study. The set-up allowed the determination of the repeatability variance, s(2)r and the between-laboratory variance, s(2)L. Combination of s(2)r and s(2)L results in the reproducibility variance s(2)R. It has been shown how these data can be used in future by a single laboratory that wants to make an uncertainty statement concerning the same analysis. [less ▲]

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See detailLe développement de la filière "Poulet d'Ardenne" en Région Wallonne
Leroy, Pascal ULiege

in Troupeaux et cultures des tropiques (2003), 2

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See detailThe extraforaminal juxtafacet cyst as a rare cause of L5 radiculopathy: a case report.
Salmon, Bernard L; Deprez, Manuel ULiege; Stevenaert, Achille ULiege et al

in Spine (2003), 28(19), 405-7

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal ... [more ▼]

STUDY DESIGN: This is a report of a case. OBJECTIVE: To document the clinical, radiographic, and histologic characteristics of a lumbar extraforaminal juxtafacet cyst. SUMMARY OF BACKGROUND DATA: Spinal juxtafacet cysts develop most frequently at the dorsal aspect of the zygapophysial joint, sometimes in the posterolateral area of the canal. In one case, they have been described in the foraminal and extraforaminal region. METHODS: Description of the case report. RESULT: The authors report one case of a strictly extraforaminal juxtafacet cyst responsible for L5 sciatica. CONCLUSIONS: Juxtafacet cysts of the spine represent an infrequent cause of sciatica, usually when they grow in the canal, or more exceptionally when they occupy the foraminal or extraforaminal areas. [less ▲]

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See detailSpinal mechanisms contribute to analgesia produced by epidural sufentanil combined with bupivacaine for postoperative analgesia
Joris, Jean ULiege; Jacob, Eric; Sessler, Daniel et al

in Anesthesia and Analgesia (2003), 97

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULiege; Martiniello, Marco ULiege

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailMéthodologie des plans de gestion piscicole en Région wallonne, application au bassin de la Semois
Conjaerts, C.; Hauptmann, Y.; Waltzing, D. et al

in Pêcheur Belge (Le) (2003), (8), 22-25

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See detailEffect of somatic growth, strain and sex on double-chamber plethymosgraphic respiratory function values in healthy mice
Flandre, Th.; Leroy, Pascal ULiege; Desmecht, Daniel ULiege

in Journal of Applied Physiology (2003), 94(3), 1129-1136

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See detailOptimisation de la transformation génétique de la pomme de terre par Agrobacterium tumefaciens. Utilisation de la résistance à l'hygromycine comme marqueur sélectif.
M'Hamdi, M.; Rouvière, C.; Rojas-Beltran J et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7

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See detailMemory processing during human sleep as assessed by functional neuroimaging.
Maquet, Pierre ULiege; Peigneux, Philippe ULiege; Laureys, Steven ULiege et al

in Revue Neurologique (2003), 159(11 Suppl), 627-9

Sleep is believed to participate in memory consolidation, possibly through off-line processing of recent memory traces. In this paper, we summarize functional neuroimaging data testing this hypothesis ... [more ▼]

Sleep is believed to participate in memory consolidation, possibly through off-line processing of recent memory traces. In this paper, we summarize functional neuroimaging data testing this hypothesis. First, sleep deprivation disrupts the processing of recent memory traces and hampers the changes in functional segregation and connectivity which underpin the gain in performance usually observed in subjects allowed to sleep on the first post-training night. Second, experience-dependent changes in regional brain activity occur during post-training sleep. These changes are shown to be related to the processing of high-level material and to be modulated by the amount of learning achieved during the training session. These changes do not involve isolated brain areas but entire macroscopic cerebral networks. These data suggest a role for sleep in the processing of recent memory traces. [less ▲]

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See detailThe fate of the adjacent motion segments after lumbar fusion.
Gillet, Philippe ULiege

in Journal of Spinal Disorders & Techniques (2003), 16(4), 338-45

Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional ... [more ▼]

Lumbar spine fusion is a commonly performed procedure in various pathologic conditions of the spine. Its role remains debated, and moreover, delayed complications may occur, among which is transitional segment alteration leading to recurrence of back pain, gross instability, and neurologic symptoms. Little is known about the long-term prevalence of this complication because of a lack of specific studies. We analyzed the fate of the transitional segments in a homogeneous group of patients operated on during a 14-year period for degenerative conditions of the lumbar spine resistant to conservative treatment. Follow-up ranged from 2 to 15 years. Seventy-five percent of our study group had a minimal 5-year follow-up. In this subgroup, 41% of the patients developed transitional segment alterations, and 20% needed a secondary operation for extension of the fusion. Potential risk factors such as postoperative delay, length of fusion, and spine imbalance were recognized. The frequency of delayed alterations of the adjacent segment and the severity of symptoms related to this complication in this study raise questions about the justification of fusion procedures in degenerative conditions of the spine without threatening instability. Data from the literature confirm the severity of the problem, but many uncertainties remain because of the lack of homogeneous and complete data on both the normal evolution of motion segments of the lumbar spine with age and the fate of the same segments when transformed in transitional segments. Future prospective studies on the subject are needed and must deal with homogeneous groups of patients. More reconstructive surgical procedures need to be developed to lessen the need for fusion procedures. [less ▲]

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULiege; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailPhase III randomized study comparing 5 or 10 microg per kg per day of filgrastim for mobilization of peripheral blood progenitor cells with chemotherapy, followed by intensification and autologous transplantation in patients with nonmyeloid malignancies.
Andre, Marc; Baudoux, Etienne ULiege; Bron, Dominique et al

in Transfusion (2003), 43(1), 50-7

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic ... [more ▼]

BACKGROUND: It is not known whether increasing the dose of filgrastim after mobilizing chemotherapy improves collection of peripheral blood progenitor cells (PBPC) and leads to faster hematopoietic engraftment after autologous transplantation. STUDY DESIGN AND METHODS: A randomized, open-label, multicenter trial was carried out in patients with breast cancer, multiple myeloma, and lymphoma, in which patients were randomized to receive 5 or 10 microg per kg per day of filgrastim after standard chemotherapy to mobilize PBPCs. After high-dose chemotherapy, the components from the first two leukapheresis procedures were returned, and all patients received 5 microg per kg day of filgrastim after transplantation. RESULTS: A total of 131 patients were randomized, of whom 128 were mobilized (Group A, 5 microg/kg, n = 66; Group B, 10 microg/kg, n = 62) and 112 were transplanted. Only six patients were not transplanted because of insufficient CD34+ cell numbers. The median number of CD34+ cells collected in the first two leukapheresis procedures tended to be higher in Group B than in Group A (12.0 vs. 7.2 x 10(6)/kg, NS), but after transplantation there was no significant difference in median times to platelet (9 days in both groups) or neutrophil (8 days in both groups) engraftment or the number of platelet transfusions (three in both groups). A subsequent subgroup analysis separating patients transplanted after first- or second-line chemotherapy also showed no measurable impact of filgrastim dose on the median CD34+ cell yield or on platelet engraftment in either subgroup. CONCLUSION: PBPC mobilization with chemotherapy and 5 microg per kg of filgrastim is very efficient, and 10 microg per kg of filgrastim does not provide additional clinical benefit. [less ▲]

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See detailPetrology of the Lyngdal granodiorite (southern Norway) and the role of fractional crystallization in the genesis of Proterozoic rapakivi-like granites
Bogaerts, Michel; Scaillet, Bruno; Liégeois, Jean-Paul ULiege et al

in Precambrian Research (2003), 124(2-4), 149-184

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULiege; Lambert, Vincent ULiege; Deprez, Manuel ULiege et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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See detailDevelopment Of Real-Time Pcr For The Rapid Detection Of Episomal Banana Streak Virus (Bsv)
Delanoy, Martine; Salmon, Marc ULiege; Kummert, Jean et al

in Plant Disease (2003), 87(1), 33-38

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See detailCaractérisation génotypique de souches invasives aviaires d'Escherichia coli isolées en Belgique
Stordeur, P.; Beaupain, N.; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 275-280

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See detailA 3-D Magnetic Vector Potential Formulation Taking Eddy Currents in Lamination Stacks Into Account
Dular, Patrick ULiege; Gyselinck, J.; Geuzaine, Christophe ULiege et al

in IEEE Transactions on Magnetics (2003), 39(3), 1424--1427

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See detailUn incunable de l'archevêque François Buisseret (1549-1615) : Réserve Précieuse de la Bibliothèque royale à Bruxelles, Inc B 1277
Adam, Renaud ULiege

in Annales de la Société Archéologique de Namur (2003), 77

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See detailLiège-Paris 1848 : Littérature, féminisme et Révolution
Droixhe, Daniel ULiege

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2003), LXXXI(1-2), 41-49

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See detailEstimation of habitat quality based on plant community, and effects of isolation in a network of butterfly habitat patches
Sawchik, J.; Dufrêne, Marc ULiege; Lebrun, Philippe

in Acta Oecologica (2003), 24(1), 25-33

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ... [more ▼]

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ecological network for five butterfly species (Brenthis ino, Clossiana selene, Lycaena helle, Lycaena hippothoe, Proclossiana eunomia) inhabiting wet meadows. Abundance predictions were performed on the basis of botanical relevés with a multiple-species approach combining canonical correspondence analysis and multiple regression. Models are defined on a reference site set and are evaluated on a test site set. All the fitted models predicted the abundance of the butterfly species considerably well (from 61 to 86% of the variation). We evaluated the potential consequences of isolation on local populations, by comparing predicted and observed abundance. It was expected that greater differences would be observed when sites were more isolated. On the test set, differences between predicted and observed abundance were largely correlated to site isolation for L. helle and P. eunomia. The most isolated sites had greater chances to be empty, even if they had high-quality habitat. Reciprocally, when the sites were less isolated, the abundance observed was always greater than predicted, seeming to confirm the role of rescue effects. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailMuscle relaxants in neurosurgical anaesthesia: a critical appraisal.
Hans, Pol ULiege; Bonhomme, Vincent ULiege

in European Journal of Anaesthesiology (2003), 20(8), 600-5

The use of muscle relaxants, considered until recently as common practice in current neurosurgical anaesthesia protocols, becomes increasingly more questionable today. The reasons rely on the evolution of ... [more ▼]

The use of muscle relaxants, considered until recently as common practice in current neurosurgical anaesthesia protocols, becomes increasingly more questionable today. The reasons rely on the evolution of neurosurgery including the advent of new surgical techniques, the evolution of anaesthesia having the benefit of new drugs and devices, and the rationale for using muscle relaxants balanced against their potential side-effects and possible pharmacodynamic alterations in neurosurgical patients. [less ▲]

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See detailEtude rétrospective de quarante et un cas d’insuffisance mitrale chez le cheval (1995-2001).
Maurin, Emmanuel; Amory, Hélène ULiege; Sandersen, Charlotte ULiege

in Pratique Vétérinaire Equine (2003), 35

Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales ... [more ▼]

Une étude rétrospective portant sur quarante et un chevaux qui présentent une insuffisance cardiaque mitrale a été réalisée afin de mieux décrire cette affection et de préciser les répercussions médicales et sportives liées à cette maladie. L'insuffisance mitrale est diagnostiquée grâce à des examens cliniques et échographiques, puis un questionnaire (évolution clinique et sportive) est adressé aux propriétaires des animaux. L’analyse de ces dossiers permet en particulier d’évaluer, d'une part, l’existence d’une association entre les signes d’insuffisance cardiaque congestive et certaines lésions cardio-vasculaires (lésions valvulaires, dilatation de l’atrium gauche, etc.) ou d'autres symptômes (fibrillation auriculaire, etc.), d'autre part, d’apprécier la corrélation éventuelle entre ces différents symptômes ou lésions et la survie des chevaux affectés. Les résultats ainsi que les biais possibles de cette étude sont ensuite discutés. [less ▲]

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See detailCase 61: ileocecal sarcoidosis.
NCHIMI LONGANG, Alain ULiege; Francotte, Nadine; Rausin, Leon et al

in Radiology (2003), 228(2), 452-5

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : I) les adhésines et facteurs de colonisation
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(2, APR-MAY), 105-126

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections): If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This first manuscript presents the current knowledge on the receptors, roles in pathogenesis, structures, genetic determinism and identification methods of fimbrial adhesins of P (Pap, Prs), S (Sfa, F1C, Sfr) and F17 (Vir, Att25, FY, 20K, G, Att111) families and of afimbrial adhesins of Afa family (Afa, Nfa, F1845, Bma, Dr...). [less ▲]

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See detailCacophonie jurisprudentielle autour de la notion d’impôt
Rosoux, Géraldine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

The article analyzes a decision of the Belgian judicial Supreme Court concerning the concept of "tax", and emphasizes the conflict between this decision and the case-law of the Belgian constitutional Court

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See detailWriting and the Other Arts in Wilson Harris's Fiction
Maes-Jelinek, Hena ULiege

in Commonwealth : Essays and Studies (2003), SP 5

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See detailLeçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspension
Rosoux, Géraldine ULiege

in Revue Belge de Droit Constitutionnel (2003)

The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.

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See detailMycoplasma bovis : synthèse des connaissances actuelles
Thomas, Anne; Mainil, Jacques ULiege; Linden, Annick ULiege

in Annales de Médecine Vétérinaire (2003), 147(1, FEB-MAR), 23-39

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia ... [more ▼]

Mycoplasmas frequently infect cattle. Amongst them, M. Bovis is the most pathogenic species in countries free from contagious bovine pleuropneumonia because it is responsible for bronchopneumonia, arthritis and mastitis, and is thus associated with strong economic losses. Several studies have shown the frequency of M. bovis in Europe and the spread of antibiotic-resistant strains. Considering the absence of vaccine in Europe, it is essential to understand this bacteria in order to control the infection in cattle. In this context, this paper aims at summarizing the current knowledge about M. bovis. [less ▲]

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See detailL'interprétation des clauses d'une police d'assurance en cas de doute
Paris, Catherine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailLe complexe Chrysoperla carnea en Belgique (Neuroptera : Chrysopidae)
Bozsik, Andras; Mignon, Jacques ULiege; Gaspar, Charles

in Notes Fauniques de Gembloux (2003), 50

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à ... [more ▼]

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à l’aide d’un filet représente le principal mode d’échantillonnage. Les individus capturés furent identifiés sur base des descriptions de Thierry et al. (1992), Duelli (1995, 1999 communication personnelle), ainsi que par comparaison, soit avec différents types morphologiques (de D. Thierry), soit à des individus identifiés sur base de leurs chants (par P. Duelli). Chrysoperla kolthoffi sensu Cloupeau (Ch.c.c.4. ou « motorboat » sensu Henry) constitue le taxon le plus représenté dans les différentes localités. Chrysoperla carnea sensu Cloupeau (« low motorboat » sensu Henry) est également souvent rencontrée abondamment, principalement en automne. Seule Chrysoperla lucasina Lacroix est observée plus rarement chaque année et dans chaque lieu. La fréquence saisonnière de Ch. carnea s.C. est variable. Ainsi, elle est relativement faible en été et elle augmente progressivement au cours de l’automne. A cette période, les proportions de Ch. kolthoffi diminuent tandis que le taux de Ch. lucasina reste stable. [less ▲]

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See detailPhysical and textural characteristics of hydrogenated low-erucic acid rapeseed oil and low-erucic acid rapeseed oil blends
Danthine, Sabine ULiege; Deroanne, Claude ULiege

in Journal of the American Oil Chemists' Society (2003), 80(2), 109-114

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat ... [more ▼]

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat content, melting curves by DSC, textural properties, and polymorphism. Phase behavior diagrams were constructed from the DSC and X-ray results, and isosolid diagrams were constructed from the NMR results. The mixture of HLERO and LERO displayed a monotectic behavior for all the storage time at 15degreesC. The aim of this work was to evaluate physical characteristics of binary blends of HLERO and nonhydrogenated LERO in order to use only LERO and hardened LERO in bakery shortenings. The mixture of 60% HLERO and 40% LERO is suitable to use as a plastic shortening, This blend is beta tending upon storage at 15degreesC. It could be used in pie crust applications. [less ▲]

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See detailDevelopment and validation of a specific radioimmunoassay for equine osteocalcin
Carstanjen, Bianca; Sulon, Joseph ULiege; Banga-Mboko, H. et al

in Domestic Animal Endocrinology (2003), 24(1), 31-41

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard ... [more ▼]

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard, tracer, and immunogen for antibody formation in rabbits. The assay allowed to measure equine serum OC levels with a sensitivity of 0.2 ng/mL. Immunoreactive serum OC values of clinically normal, different-aged horses ranged from 3.68 to 127.31 ng/mL. Intra- and inter-assay coefficients of variation (CV) were 6.2 and 8.2%, respectively. Serial equine scrum sample dilutions were linear. The recovery of equine OC from equine serum samples ranged from 93.88 to 107.9%. There was a tight correlation between OC values measured with the equine- specific OC RIA and two commercially available bovine-specific OC RIA kits. However, highest serum OC values were obtained with the equine-specific OC RIA. In conclusion, our equine-specific OC RIA is sensitive, linear, accurate, precise, and reproducible. The assay allowed to quantify OC in equine serum samples and might, therefore, be used to monitor equine osteoblast activity associated with bone diseases, exercise, therapy forms or diet. [less ▲]

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See detailEffet de l'intensité d'un stimulus gravitationnel induit artificiellement sur la croissance et la formation du bois de tension dans de jeunes pousses de peuplier (Populus euramericana cv. Ghoy).
Jourez, Benoit; Vaianopoulos, Céline; Hebert, Jacques ULiege

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60(8), 789-802

The formation of tension wood tissue is artificially induced by means of a gravitational stimulus obtained by inclining young shoots of poplar at different intensities, from 0 to 30°, during a growing ... [more ▼]

The formation of tension wood tissue is artificially induced by means of a gravitational stimulus obtained by inclining young shoots of poplar at different intensities, from 0 to 30°, during a growing season. At the end of the experiment, it appears that shoot elongation as well as the angle of tension wood arc are not affected by the stimulus intensity. In contrast, the upright reorientation of the axis, the amount of gelatinous fibres, the secondary growth over bark, the cross-section area of the stem and of the secondary xylem, the different rays, the diameter under bark and the pith eccentricity, react quantitatively to the lean intensity. The amount of tension wood is correlated with the upright reorientation, the secondary growth over bark and the radial growth under bark. Tension wood formation and eccentricity react to the gravitational stimulus but they are not causally linked. Finally, it exists a natural equilibrium position, different from the vertical, to which moved shoots try to return via the formation of a tension wood tissue. [less ▲]

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See detailAccuracy of the continuous glucose monitoring system in inpatient and outpatient conditions
Djakouré-Platonoff, C.; RADERMECKER, Régis ULiege; Reach, G. et al

in Diabètes & Métabolism (2003), 29

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See detailA model of the seasonal dynamics of biomass and production of the seagrass Posidonia oceanica in the Bay of Calvi (Northwestern Mediterranean)
Elkalay, Khalid; Frangoulis, Constantin; Skliris, Nikolaos ULiege et al

in Ecological Modelling (2003), 167(1-2), 1-18

Modelling of seagrasses can be an effective tool to assess factors regulating their growth. Growth and production model of Posidonia oceanica, the dominant submerged aquatic macrophyte occurring in the ... [more ▼]

Modelling of seagrasses can be an effective tool to assess factors regulating their growth. Growth and production model of Posidonia oceanica, the dominant submerged aquatic macrophyte occurring in the Bay of Calvi (Corsica, Ligurian Sea, Northwestern (NW) Mediterranean) was developed. The state variables are the above- and below-ground biomass of P oceanica, the epiphyte biomass, and the internal nitrogen concentration of the whole plant. Light intensity and water temperature are the forcing variables. The model reproduces successfully seasonal growth and production for each variable at various depths (10, 20 and 30 m). The model can simulate also a number of consecutive years. Sensitivity analysis of model's parameters showed that the maximum nitrogen quota n(max) rate is the most sensitive parameter in this model. The results simulations imply that light intensity is one of the most important abiotic factors, the diminution of which can cause an important reduction in seagrass density. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailLarge phosphorus hyperfine coupling as a sensitive tool for studying molecular dynamics : ESR and Molecular Mechanics studies of ring interconversion in cis-2,5-diphosphoryl-2,5-dimethyl-pyrrolidinoxyl radical
Rockenbauer, Antal; Gaudel-Siri, Anouk; Siri, Didier et al

in Journal of Physical Chemistry A (2003), 107(19), 3851-3857

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was ... [more ▼]

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was observed for t-1; however, for c-1, the inner lines of the 1:2:1 triplet showed a dramatic broadening characteristic of chemical exchange between two equivalent conformations. Owing to the large difference in the hyperfine splitting constants (hfsc) of the exchanging phosphorus (¢aP 21 G), the coalescence temperature was unusually high (193 K, in n-pentane), and the potential barrier for ring interconversion (10.5 kJ mol-1) was easily obtained from the temperature dependence of the exchange rate. This value was in very good agreement with the value obtained for an empirical pseudorotational potential (11 kJ mol-1) that was adjusted to fit the temperature dependence of the phosphorus hfsc. For c-1, molecular mechanics calculations gave similar characteristics for the pseudorotational potential and indicated the existence of two identical minima with distorted geometries lying between 3T4 and 3E or 4T3 and E3. For t-1, only the 3T4 conformer was found to be significantly populated. Frozen solution spectra showed that the phosphorus hfsc anisotropy is higher when the C-P bond is pseudoaxial; this result can be explained by a geometry-dependent delocalization of the unpaired electron into the phosphorus 3p orbitals. [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : II) Franchissement des muqueuses et propriétés invasives
Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(3, JUN-JUL), 159-171

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, entero-haemorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains : adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This second manuscript presents the current knowledge on the transmucosal transfer, resistance to the bactericidal activity of the complement, resistance to phagocytosis and production of colicins, that were, for several years, considered as an important specific property of invasive strains of E coli. [less ▲]

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See detailLa Zone Villageoise de Chasse de Sia (Ranch de Gibier de Nazinga, Burkina Faso)
Vermeulen, Cédric ULiege; Ouédraogo, M.

in Parcs & Réserves (2003), 58(2), 32-44

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See detailAltered neuronal excitability in cerebellar granule cells of mice lacking calretinin
Gall, D.; Roussel, C.; Susa, I. et al

in Journal of Neuroscience (2003), 23(28), 9320-9327

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar ... [more ▼]

Calcium-binding proteins such as calretinin are abundantly expressed in distinctive patterns in the CNS, but their physiological function remains poorly understood. Calretinin is expressed in cerebellar granule cells, which provide the major excitatory input to Purkinje cells through parallel fibers. Calretinin-deficient mice exhibit dramatic alterations in motor coordination and Purkinje cell firing recorded in vivo through unknown mechanisms. In the present study, we used patch-clamp recording techniques in acute slice preparation to investigate the effect of a null mutation of the calretinin gene on the intrinsic electroresponsiveness of cerebellar granule cells at a mature developmental stage. Calretinin-deficient granule cells exhibit faster action potentials and generate repetitive spike discharge showing an enhanced frequency increase with injected currents. These alterations disappear when 0.15 mm of the exogenous fast-calcium buffer BAPTA is infused in the cytosol to restore the calcium-buffering capacity. A proposed mathematical model demonstrates that the observed alterations of granule cell excitability can be explained by a decreased cytosolic calcium-buffering capacity resulting from the absence of calretinin. This result suggests that calcium-binding proteins modulate intrinsic neuronal excitability and may therefore play a role in information processing in the CNS [less ▲]

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See detailEnergy conservation and dissipation in mitochondria isolated from developing tomato fruit of ethylene-defective mutants failing normal ripening: the effect of ethephon, a chemical precursor of ethylene.
Navet, R.; Jarmuszkiewicz, W.; Almeida, A. et al

in Journal of Bioenergetics & Biomembranes (2003), 35(2), 157-168

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two ... [more ▼]

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two energy-dissipating systems exhibit large variations during tomato fruit development and ripening on the vine. It has been suggested that AOX and UCP could be responsible for the respiration increase at the end of ripening and that the cytochrome pathway could be implicated in the climacteric respiratory burst before the onset of ripening. In this study, the use of tomato mutants that fail normal ripening because of deficiencies in ethylene perception or production as well as the treatment of one selected mutant with a chemical precursor of ethylene have revealed that the bioenergetics of tomato fruit development and ripening is under the control of this plant hormone. Indeed, the evolution pattern of bioenergetic features changes with the type of mutation and with the introduction of ethylene into an ethylene-synthesis-deficient tomato fruit mutant during its induced ripening. [less ▲]

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See detailLes protéines de choc thermique (heat shock proteins). II Les protéines de choc thermique (heat shock proteins). II. Hsp70, biomarqueur, bioprotecteur.
Wirth, Delphine; Gustin, Pascal ULiege; Drion, Pierre ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(2), 127-144

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was ... [more ▼]

The exposure of any organism to high temperature induces rapid and transient cellular overexpression of specific proteins, the heat shock proteins (Hsps). This response, called heat shock response, was initially discovered in Drosophila. The genes hsps were among the first eukaryotic genes to be cloned and whose regulation, which involves activation of heat shock factor (HSF), was elucidated. More recently, study of Hsp functions, particularly Hsp70, started. Their protective role, related to their molecular chaperon function, was inferred from experiments showing that Hsp70 expression, induced by a first stress, results in a cellular tolerance to second stress. Better understanding of the heat shock response had led to the development of two search fields on Hsp70 expression : (1) its use as biomarker of cellular stress and (2) the exploitation of its cytoprotective functions against various insults. This review includes historic of the research on the heat shock response, description of regulation mechanism of Hsp70 expression, and the interesting perspectives allocated to Hsp70 as biomarker and therapeutic tool. ----------- L’exposition de tout organisme à des températures élevées induit l'expression cellulaire rapide et transitoire de protéines spécifiques, les protéines de choc thermique (Hsps pour " heat shock proteins "). Cette réponse des cellules au choc thermique ou " heat shock response " a été initialement découverte chez la drosophile. Les gènes hsps furent parmi les premiers gènes eucaryotes à être clonés et utilisés comme paradigme dans l'étude des mécanismes de régulation transcriptionnelle faisant intervenir l'activation d'un ou plusieurs " heat shock factors" (HSFs). C'est plus récemment que l'étude des fonctions des Hsps, particulièrement Hsp70, a débuté. Le rôle protecteur de celle-ci, lié à sa fonction de " chaperon " protéique, a été déduit d'expériences montrant que l'induction de l'expression de Hsp70 lors d'un stress était associée au développement d'une tolérance cellulaire vis-à-vis d'un stress ultérieur. En plus d'un intérêt fondamental pour la compréhension de la "réponse au choc thermique", deux axes de recherche appliquée se sont développés visant à investiguer la possibilité d'utiliser l'expression de Hsp70 comme biomarqueur de souffrance cellulaire d'une part et, d'autre part, d'exploiter ses fonctions comme moyen de protection des cellules contre divers types d'agressions. Cette revue décrit l'historique des découvertes sur la " réponse au choc thermique ", le mécanisme régulant l'expression de Hsp70 ainsi que les perspectives intéressantes s'ouvrant à l'utilisation de l'expression de Hsp70 en tant que biomarqueur et outil thérapeutique. [less ▲]

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; Portetelle, Daniel ULiege et al

in Yeast (Chichester, England) (2003), 20(S1),

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See detailLes ateliers du Matériel: pivots de la diffusion de l'organisation rationnelle au sein de la Société Nationale des Chemins de fer Belges, 1910-1940
Geerkens, Eric ULiege

in Revue d'Histoire des Chemins de Fer (2003), (28-29), 207-221

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d ... [more ▼]

Les ateliers du Matériel des Chemins de fer de l'Etat belge, puis de la SNCB, ont été à la fois le point d'entrée des méthodes d'organisation rationnelle du travail et, après l'étape concluante d'expérimentation, le point de diffusion de ces méthodes vers d'autres services de la société, mais aussi vers les constructeurs belges de matériel roulant. L'introduction du système de rémunération Rowan à l'atelier central de Malines (principal atelier du matériel du réseau belge) peut être tenu pour le point de départ de l'adoption de méthodes d'organisation rationnelle, dans la mesure où elle impliquait une première forme d'étude systématique du travail ouvrier. Au lendemain de la Première Guerre, une nouvelle organisation du travail d'inspiration taylorienne et son corollaire indispensable - une comptabilité industrielle - vont être introduits dans les ateliers de moyenne réparation des locomotives. Associée initialement à une concentration des ateliers, la taylorisation ne va cesser de progresser. L'adoption du travail à la chaîne pour le placement de freins à air sur ses wagons a constitué une des innovations majeures dans l'organisation du travail à la SNCB. Forte de cette expérience, la SNCB va étendre le travail à la chaîne à d'autres travaux exécutés par le service du Matériel, puis à certaines activités d'autres services. Ainsi cette technique, adoptée pour une opération ponctuelle, va être appliquée aux travaux récurrents de réparation et d'entretien du matériel roulant. Au service de l'Exploitation, la recherche d'un équilibre optimal entre les tâches successives, déterminant majeur du rendement dans le travail à la chaîne, va fournir le principe d'une organisation nouvelle du triage des wagons; de même, les travaux d'entretien des voies vont être réorganisés de manière à les faire exécuter suivant certains principes du travail à la chaîne. La baisse du trafic de marchandises et la dégradation de ses résultats financiers au début des années '30 vont amener la SNCB à approfondir la rationalisation des différents travaux, par une combinaison de techniques déjà éprouvées et de procédures nouvelles; la gestion très centralisée des ateliers va s'appuyer sur deux techniques particulières: les plannings et le contrôle budgétaire. Par une modification de ses principes d'adjudication, la société va aussi imposer le travail à la chaîne, puis le planning, à ses fournisseurs de matériel roulant, amenant ainsi une modernisation de leurs méthodes de travail. L'adoption et la diffusion des méthodes d'organisation a impliqué une très forte centralisation des structures administratives, dont une illustration est donnée par le service d'entretien des wagons, où tous les ateliers sont dirigés par le service central des wagons de la direction du Matériel. Au début de la Seconde Guerre, les limites de cette centralisation vont être perçues par les fonctionnaires dirigeants qui avaient introduit les méthodes d'organisation tayloriennes. Il en résultera une décentralisation des responsabilités; son abandon au lendemain du conflit marque toutefois le retour à une centralisation taylorienne dont les effets se feront sentir pendant plusieurs décennies. [less ▲]

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailOptimizing treatment with thioguanine derivatives in inflammatory bowel disease.
Louis, Edouard ULiege; Belaiche, Jacques ULiege

in Bailliere's Best Practice & Research. Clinical Gastroenterology (2003), 17(1), 37-46

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe ... [more ▼]

Thioguanine derivatives, azathioprine and 6-mercaptopurine, represent major drugs in the treatment of chronic active inflammatory bowel disease. They are effective in two-thirds of the patients and safe over the long term in patients who can tolerate them (80-90%). Recent progress in understanding the metabolism of these drugs and its implication in clinical practice have brought up new tools and strategies that are proposed to optimize treatment. In particular, the measurement and characterization of key enzymes and metabolites may have clinical impact. Thus, thiopurine methyl transferase genotyping and activity measurement, as well as erythrocytes, 6-thioguanine nucleotides and 6-methyl mercaptopurine levels, may help in some situations of intolerance or inefficacy with these drugs. Indications for starting and stopping treatment with thioguanine derivatives are also discussed. [less ▲]

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Yeast (2003), 20(S291),

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See detailLes mycoplasmes respiratoires bovins: prévalence et propriétés de cyto-adhésion
Thomas, A.; Dizier, Isabelle ULiege; SACHSE, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4), 267-272

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See detailHorizontal And Vertical Co2 Advection In A Sloping Forest
Aubinet, Marc ULiege; Heinesch, Bernard ULiege; Yernaux, Michel ULiege

in Boundary-Layer Meteorology (2003), 108(3),

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See detailDetuning effects in the one-photon mazer
Bastin, Thierry ULiege; Martin, John ULiege

in Physical Review. A (2003), 67

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far ... [more ▼]

The quantum theory of the mazer in the nonresonant case (a detuning between the cavity mode and the atomic transition frequencies is present) is described. The generalization from the resonant case is far from being direct. Interesting effects of the mazer physics are pointed out. In particular, it is shown that the cavity may slow down or speed up the atoms according to the sign of the detuning and that the induced emission process may be completely blocked by use of a positive detuning. It is also shown that the detuning adds a potential step effect not present at resonance and that the use of positive detunings defines a well-controlled cooling mechanism. In the special case of a mesa cavity mode function, generalized expressions for the reflection and transmission coefficients have been obtained. The general properties of the induced emission probability are finally discussed in the hot, intermediate, and cold atom regimes. Comparison with the resonant case is given. [less ▲]

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See detailRivers, chemical weathering and Earth's climate
Dupre, B.; Dessert, C.; Oliva, P. et al

in Comptes Rendus Geoscience (2003), 335(16), 1141-1160

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at ... [more ▼]

We detail the results of recent studies describing and quantifying the large-scale chemical weathering of the main types of continental silicate rocks: granites and basalts. These studies aim at establishing chemical weathering laws for these two lithologies, describing the dependence of chemical weathering on environmental parameters, such as climate and mechanical erosion. As shown within this contribution, such mathematical laws are of primary importance for numerical models calculating the evolution of the partial pressure of atmospheric CO2 and the Earth climate at geological timescales. The major results can be summarized as follow: (1) weathering of continental basaltic lithologies accounts for about 30% of the total consumption of atmospheric CO2 through weathering of continental silicate rocks. This is related to their high weatherability (about eight times greater than the granite weatherability); (2) a simple weathering law has been established for basaltic lithologies, giving the consumption of atmospheric CO2 as a function of regional continental runoff, and mean annual regional temperature; (3) no such simple weathering law can be proposed for granitic lithologies, since the effect of temperature can only be identified for regions displaying high continental runoff; (4) a general law relating mechanical erosion and chemical weathering has been validated on small and large catchments. The consequences of these major advances on the climatic evolution of the Earth are discussed. Particularly, the impacts of the onset of the Deccan trapps and the Himalayan orogeny on the global carbon cycle are reinvestigated. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved. [less ▲]

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See detailIn vitro paradigms for the study of GnRH neuron function and estrogen effects.
Matagne, Valerie; LEBRETHON, Marie-Christine ULiege; Gerard, Arlette et al

in Annals of the New York Academy of Sciences (2003), 1007

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency ... [more ▼]

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency of GnRH secretion, the excitatory effect of glutamate, and the inhibitory or excitatory effect of GABA. Among the different paradigms, the fetal olfactory placode cultures exhibit the unique property of migration in vitro and may retain the capacity to undergo maturational changes in vitro. The short-term incubation of hypothalamic explants obtained at different ages enables one to study developmental changes as well. Estrogens may have important roles in the regulation of GnRH function and can act indirectly via the neighboring neuronal/glial apparatus and directly on GnRH neurons at the cell body and terminal levels. A direct effect is supported by the recent localization of ERalpha and ERbeta transcripts in GnRH neurons using most paradigms. Discrepant effects of estrogens on GnRH neurons were observed since GnRH biosynthesis is inhibited while GnRH secretion can be either stimulated, unaffected, or reduced. It is likely that the regulatory role of sex steroids including estradiol is very complex since it could involve direct and indirect effects on GnRH neurons through genomic and/or non-genomic mechanisms. [less ▲]

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See detailBasalt weathering laws and the impact of basalt weathering on the global carbon cycle
Dessert, C.; Dupre, B.; Gaillardet, J. et al

in Chemical Geology (2003), 202(3-4), 257-273

This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth ... [more ▼]

This study attempts to characterise the chemical weathering of basalts and to quantify the flux of carbon transferred from the atmosphere to the ocean during this major process at the surface of the Earth. To this aim, we have compiled different published chemical compositions of small rivers draining basalts. Basaltic river waters are characterised by relatively high Na-normalized molar ratios (Ca/Na: 0.2-3.9; HCO3/Na: 1-10; Mg/Na: 0.15-6) in comparison with those usually observed for river draining silicates. The data also show the climatic influence on basalt weathering and associated CO2 consumption. Runoff and temperature are the main parameters controlling the chemical weathering rate and derived CO2 consumption during basaltic weathering. From these relationships and digital maps, we are able to define the contribution of basalts to the global silicate flux. Taking account of this result, we estimate that the CO2 flux consumed by chemical weathering of basalts is about 4.08 x 10(12) mol/year. The fluxes from the islands of Indonesia and regions of central America represent around 40% of this flux. The global flux of CO2 consumed by chemical weathering of basalts represents between 30% and 35% of the flux derived from continental silicate determined by Gaillardet et al. [Chem. Geol. 159 (1999) 3]. Finally, it appears that volcanic activity not only acts as a major atmospheric CO2 source, but also creates strong CO2 sinks that cannot be neglected to better understand the geochemical and climatic evolution of the Earth. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailIntensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé; Lepage, Eric; Coiffier, Bertrand et al

in Blood (2003), 102(13), 4284-4289

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide ... [more ▼]

We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology. [less ▲]

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See detailThe Sturtian 'snowball' glaciation: fire and ice
Godderis, Y.; Donnadieu, Y.; Nedelec, A. et al

in Earth And Planetary Science Letters (2003), 211(1-2), 1-12

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset ... [more ▼]

The Sturtian 'snowball' glaciation (730 Ma) is contemporary with the dislocation of the Rodinia supercontinent. This dislocation is heralded and accompanied by intense magmatic events, including the onset of large basaltic provinces between 825 and 755 Ma. Among these magmatic events, the most important one is the onset of a Laurentian magmatic province at 780 Ma around a latitude of 30degreesN. The presence of these fresh basaltic provinces increases the weatherability of the continental surfaces, resulting in an enhanced consumption of atmospheric CO2 through weathering, inducing a global long-term climatic cooling. Based on recent weathering laws for basaltic lithology and on climatic model results, we show that the weathering of a 6 x 10(6) km(2) basaltic province located within the equatorial region (where weathering of the province and consumption of CO2 are boosted by optimal climatic conditions) is sufficient to trigger a snowball glaciation, assuming a pre-perturbation PCO2 value of 280 ppmv. We show that the Laurentian magmatic province might be the main culprit for the initiation of the Sturtian 'snowball' glaciation, since the Laurentian magmatic province had drifted within the equatorial region by the time of the glaciation. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitro
Thomas, Anne; Dizier, Isabelle ULiege; Sachse, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]

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See detail(Ex)communication
Dumortier, Jean-Louis ULiege

in Lettre de la DLFM (2003), 32

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See detailHierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies
Blin, J.-L.; Léonard, Alexandre ULiege; Yuan, Z.-Y. et al

in Angewandte Chemie International Edition (2003), 42(25), 2872-2875

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like ... [more ▼]

Wormhole-like mesoporous walls are observed within macroporous metal oxides that were synthesized in one step using nonionic alkyl-PEO surfactants as templates. The uniform macropores have a funnel-like shape (tapered towards the center) and are arranged parallel to each other and perpendicular to the tangent of the particle surface (see micrographs). The mesochannels are interconnected with funnel-like macrochannels. [less ▲]

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See detailEvent-related potentials to emotional and neutral stimuli in alcoholism.
Hansenne, Michel ULiege; Olin, Cecile; Pinto, Emmanuel ULiege et al

in Neuropsychobiology (2003), 48(2), 77-81

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated ... [more ▼]

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated. Subjects were 10 alcoholic inpatients (3 female) and 10 age- and sex-matched controls. Eight alcohol-related and 8 neutral words served as stimuli in a visual oddball paradigm. Acohol-related words were targets (48 stimuli, 33%) and neutral words were standard stimuli (96 stimuli, 66%). Results showed that P300 amplitude for targets did not differ significantly between the two groups. However, P300 latency for targets as well as reaction time were significantly shorter in male alcoholic patients. In contrast, P300 latency was increased in female alcoholic patients but reaction time did not differ. These results suggest that male alcoholics process information linked to alcohol cues more rapidly than neutral cues, probably because a specific semantic network is activated in these patients. The decreased reaction time confirms the impulsive behavior frequently found in male alcoholism, as it has been described in type II alcoholism. Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing. [less ▲]

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See detailMycobacterium bovis meningitis in a cow with clinical signs of BSE.
Roels, S.; Walravens, K.; Saegerman, Claude ULiege et al

in Veterinary Record : Journal of the British Veterinary Association (2003), 152(26), 807-8

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See detailA arbitragem e os grupos de sociedades
Caprasse, Olivier ULiege

in Revista de Direito Bancario, do Mercado de Capitais e da Arbitragem (2003)

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