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See detailFormes et formalités. Remarques sur la poétique du nom chez Mallarmé
Durand, Pascal ULg

in Formules (2000), 4

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See detailUse of ciliogenesis in the diagnosis of primary ciliary dyskinesia in a dog
Clercx, Cécile ULg; Peeters, Dominique ULg; Beths, T. et al

in Journal of the American Veterinary Medical Association [=JAVMA] (2000), 11

Primary ciliary dyskinesia is a congenital condition that may cause chronic rhinitis and bronchopneumonia. Primary ciliary dyskinesia may be diagnosed by induction of ciliogenesis by use of in vitro cell ... [more ▼]

Primary ciliary dyskinesia is a congenital condition that may cause chronic rhinitis and bronchopneumonia. Primary ciliary dyskinesia may be diagnosed by induction of ciliogenesis by use of in vitro cell culture. Induction of ciliogenesis allows for differentiation between primary and secondary ciliary dyskinesia. [less ▲]

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See detailSeismic hazard in the Sea of Marmara following the Izmit Earthquake
Hubert, Aurelia ULg; Barka, Aykut; Jacques, Eric et al

in Nature (2000), 404

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average ... [more ▼]

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average rate of 2–3 cm yr−1 (refs 3–5), and historically has been the site of many devastating earthquakes6,7. This century alone it has ruptured over 900 km of its length6. Models of earthquake-induced stress change8 combined with active fault maps9 had been used to forecast that the epicentral area of the 1999 Izmit event was indeed a likely location for the occurrence of a large earthquake9,10. Here we show that the 1999 event itself significantly modifies the stress distribution resulting from pre- vious fault interactions9,10. Our new stress models take into account all events in the region with magnitudes greater than 6 having occurred since 1700 (ref. 7) as well as secular interseismic stress change, constrained by GPS data11. These models provide a consistent picture of the long term spatio–temporal behaviour of the North Anatolian fault and indicate that two events of magnitude equal to, or greater than, the Izmit earthquake are likely to occur within the next decades beneath the Marmara Sea, south of Istanbul. [less ▲]

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See detailDevelopment Of An In Vitro Pod Culture Technique For Young Pods Of Phaseolus Vulgaris L.
Geerts, P.; Sassi, K.; Mergeai, Guy ULg et al

in In Vitro Cellular & Developmental Biology-Plant (2000), 36(6),

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See detailControl of perimenstrual flares of perioral dermatitis by isotretinoin
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Journal of Dermatological Treatment (2000), 11

BACKGROUNDS: Some cases of perioral dermatitis (POD) appear in young women after the interruption of oral contraception. Perimenstrual POD flares may also occur. Blue-brown, post-inflammatory macules and ... [more ▼]

BACKGROUNDS: Some cases of perioral dermatitis (POD) appear in young women after the interruption of oral contraception. Perimenstrual POD flares may also occur. Blue-brown, post-inflammatory macules and atrophic scarring often persist. Conventional treatment modalities include topical and oral tetracyclines, topical metronidazole and oral contraceptives. However, such therapies mau fail or offer only transient results. Isotretinoin efficacy was reported in a patient with difficult-to-treat POD. METHODS: We studied the outcome of a 6-month course of isotretinoin with a 1-year follow-up in 14 women suffering from chronic or recurrent POD refractory to or dependent on long-term conventional treatments. The isotretinoin dosing regiments were based on acne management guidelines. RESULTS: At 1-year follow-up, 12 of 14 (85,7 %) of the women remained free of POD recurrences, one patient (7,1 %) experienced a significant improvement, and one patient (7,1 %) showed only transient improvement during therapy, and rapidly relapsed after completing two 6-month treatment courses. The muco-cutaneous side effects were similar to those already known for isotretinoin. No other adverse effects occured. CONCLUSION: Isotretinoin represents a valuable therapeutic alternative for women suffering from chronic or recurrent POD refractory to or dependent on conventional treatment options. [less ▲]

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See detailA FETD Approach for the Modeling of Antennas
Geuzaine, Christophe ULg; Meys, B.; Beauvois, Véronique ULg et al

in IEEE Transactions on Magnetics (2000), 36(4), 892--896

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See detailLe médecin généraliste face à l'urgence dentaire.
Dabée, Jean-Claude ULg; Geerts, Sabine ULg; Charpentier, Joseph ULg

in Revue Médicale de Liège (2000), 55(12), 1022-7

Counselling and drug prescription are the only means for the phycisian to manage dental emergencies. Among these, some are infection related: pulpitis, apical and periodontal abscesses, acute necrotizing ... [more ▼]

Counselling and drug prescription are the only means for the phycisian to manage dental emergencies. Among these, some are infection related: pulpitis, apical and periodontal abscesses, acute necrotizing ulcerative gingivitis and alveolitis. Urgent medical treatment includes antibiotics, mouth rinses and analgesics except for pulpitis (pain caused by thermal stimuli) for which analgesics alone are prescribed. Infection non related dental emergencies are: hemorrhage for which the best treatment is compression; trauma, mainly dental avulsion for which reimplantation must be done as soon as possible; acute TMD such as open lock which can be reduced by the Nelaton handling. [less ▲]

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See detailLes propriétés de la glucosamine
Reginster, Jean-Yves ULg; Halkin, V

in Journal de Pharmacie de Belgique (2000), 55(5), 118-121

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See detailThe Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier ULg; Mainil, Jacques ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 115-22

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An ... [more ▼]

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals. [less ▲]

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See detailPAM, sediments, and interrupted flow effects on rill erosion and Intake rate
Sirjacobs, Damien ULg; Shainberg, Itzhak; Rapp, Iddo et al

in Soil Science Society of America Journal (2000), 64

The reduction in the intake rate (IR) during interrupted irrigation is difficult to predict. Sediments in irrigation water decrease the effect of interrupted irrigation on IR. Polyacrylamide (PAM) reduces ... [more ▼]

The reduction in the intake rate (IR) during interrupted irrigation is difficult to predict. Sediments in irrigation water decrease the effect of interrupted irrigation on IR. Polyacrylamide (PAM) reduces rill erosion, but its effect on IR is controversial. The effects of water quality (tap water, tap water containing sediments, and 10 g m−3 PAM solution) and interrupted flow on IR and rill erosion in an Alfisol (Calcic Haploxeralf) and a Vertisol (Typic Chromoxerert) were studied using laboratory miniflumes. Rill erosion in both soils was eliminated by the PAM treatment in both continuous and interrupted flow. The PAM application reduced IR in the Alfisol and increased it in the Vertisol. In the Alfisol, interrupted flow reduced IR of the PAM solution by 37% compared with only 18% for tap water. In the Vertisol, interrupted flow reduced IR only slightly and the decrease was not affected by the polymer. When the water contained sediments, cumulative infiltration was reduced by 22% for the Vertisol and 59% for the Alfisol in comparison with tap water. These reductions were attributed to depositional seal formation. The IR of the Alfisol was more susceptible to depositional seal formation than the Vertisol. The presence of sediments in water was effective in reducing rill erosion. The effects of interrupted flow with PAM on reducing IR were explained by partial blocking of the conducting pores leading to greater suction and compaction of the soil surface. For sediment-laden irrigation water, interrupted flow had no advantage over continuous flow in reducing IR because of depositional seal formation associated with the sediments in the water. [less ▲]

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See detailA clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine.
Boureau, F.; Kappos, L.; Schoenen, Jean ULg et al

in International Journal of Clinical Practice (2000), 54(5), 281-6

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray ... [more ▼]

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray (20 mg) with dihydroergotamine (DHE) nasal spray (1 mg plus optional 1 mg). At the primary efficacy time point of 60 minutes after dosing, significantly more patients obtained headache relief (change from moderate or severe to none or mild) after treatment with sumatriptan than with DHE (53% sumatriptan, 41% DHE, p < 0.001). Significantly more patients reported relief of nausea after sumatriptan than after DHE at 60 minutes (64% sumatriptan, 49% DHE, p = 0.006). A significant difference between the two treatments was first observed at 45 minutes with respect to both headache relief (38% sumatriptan, 31% DHE, p = 0.037) and relief of nausea (55% sumatriptan, 40% DHE, p = 0.014). There were no significant differences between the two treatments for other measures of efficacy. Both treatments were well tolerated, with only 10% of patients in each group reporting one or more adverse events. The most frequently reported adverse event after sumatriptan was a bad or bitter taste, which was reported by 5% of patients. After DHE, 4% of patients reported symptoms of the nasal cavity/sinuses and 3% reported nausea and/or vomiting as adverse events. It is concluded that sumatriptan nasal spray is superior to DHE nasal spray in the relief of pain and nausea associated with acute migraine headache. [less ▲]

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See detailA quantitative study of peripheral blood stem cell contamination in diffuse large-cell non-Hodgkin's lymphoma: one-half of patients significantly mobilize malignant cells.
Jacquy, C.; Soree, A.; Lambert, Frédéric ULg et al

in British Journal of Haematology (2000), 110(3), 631-7

Autologous transplantation using peripheral blood stem cells (PBSCs) collected after chemotherapy, followed by growth factor administration (ASCT), is increasingly used in the treatment of non-Hodgkin's ... [more ▼]

Autologous transplantation using peripheral blood stem cells (PBSCs) collected after chemotherapy, followed by growth factor administration (ASCT), is increasingly used in the treatment of non-Hodgkin's lymphoma (NHL). However, quantitative data regarding contaminating malignant cells in the harvests are still scarce. We prospectively investigated 37 diffuse large-cell lymphomas (DLCLs) in complete remission (CR) that were treated according to multicentric protocols at our centre. DNA was extracted from the diagnostic lymph node. The complementarity-determining region (CDR) III was sequenced and a patient-specific oligomer synthesized. Contamination was evaluated semiquantitatively by polymerase chain reaction (PCR) and was confirmed by a limiting dilution analysis. PBSCs collected at regeneration after administration of granulocyte colony-stimulating factor (G-CSF), steady-state bone marrow (BM) and peripheral blood samples at CR were compared. DNA was available in 37 patients, from which 22 rearrangements could be sequenced. Patients (n = 15) who had both the required follow-up samples and a suitable clonal marker were investigated. In two cases, the patient-specific PCR assay set up at diagnosis later gave false-negative results in samples in which clonal DNA was still detectable by other sets of primers. PBSC contamination was highly variable: 7 out of 15 patients showed a PBSC/BM ratio of NHL cells greater than 1 log, whereas 8 out of 15 patients showed no difference and could vary from one apheresis to another. Eight ASCTs were performed, five of which used highly contaminated PBSCs: four patients relapsed early, three with disseminated lymphoma. Thus, 50% of DLCLs in CR seem to mobilize significantly malignant cells at regeneration under G-CSF. Considering the higher numbers of cells reinfused, this translates into a much higher number of lymphoma cells reinfused when compared with autologous bone marrow transplantation (ABMT). However, their clonogenic potential remains unknown and, despite concerning observations in certain cases, it is still unclear whether this has an impact upon the outcome of ASCT. [less ▲]

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See detailIAA-oxidase activity and auxin protectors in nonrooting, rac, mutant shoots of tobacco in vitro
Faivre-Rampant, Odile; Kevers, Claire ULg; Gaspar, Thomas ULg

in Plant Science (2000), 153(1), 73-80

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared ... [more ▼]

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared to its wild homologue. The mutant and wild shoots showed similar peroxidase variations along the growth cycle of 21 days, but with higher levels of activity for the I ac mutant. During this growth cycle, the minimum of peroxidase activity occurred at day 14 for both tobacco whole shoots. However. this minimum of activity did not occur at the same day in the basal part of the stem, where roots may appear, of the two types of tobacco. Both mutant and wild whole shoots showed about the same IAA-oxidase activity in the fractions resulting from a gel filtration of the crude extracts through a sephadex G-100 column but differed in the degree of auxin protection. The rac shoots exhibited a very high level of auxin protectors of low molecular weight, among which chlorogenic acid. They were also characterized by eight to nine times higher level of soluble phenolics. The relationships between these biochemical aspects in relation to the absence of root formation in the me mutant are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailBiocompatibility of polyethylene glycols (PEG): An approach using bovine serum albumin (BSA) as a protein model.
Loret, S; Gilson, P; Barakat, I et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailAn automata-theoretic approach to branching-time model checking
Kupferman, Orna; Vardi, Moshe Y; Wolper, Pierre ULg

in Journal of the ACM (2000), 47(2), 312-360

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this ... [more ▼]

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this verification method. On the other hand, for branching temporal logic, automate-theoretic techniques have long been thought to introduce an exponential penalty, making them essentially useless for model-checking. Recently, Bernholtz and Grumberg [1993] have shown that this exponential penalty can be avoided, though they did not match the linear complexity of non-automata-theoretic algorithms. In this paper, we show that alternating tree automata are the key to a comprehensive automata-theoretic framework for branching temporal logics. Not only can they be used to obtain optimal decision procedures, as was shown by Muller ct al., but, as we show here, they also make it possible to derive optimal model-checking algorithms. Moreover, the simple combinatorial structure that emerges from the automata-theoretic approach opens up new possibilities for the implementation of branching-time model checking, and has enabled us to derive improved space complexity bounds for this long-standing problem. [less ▲]

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See detailLes débuts de l'humanité dans le Prométhée enchaîné d'Eschyle
Renaud, Jean-Michel ULg; Wathelet, Paul ULg

in Uranie : Mythes et Littératures (2000), 9

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See detailLandmarks in the theory of mass spectra
Lorquet, Jean-Claude ULg

in International Journal of Mass Spectrometry (2000), 200(1-3), 43-56

Statistical theories of mass spectra are based on two assumptions. The first one, which postulates efficient phase space sampling, is substantiated by various experimentation and is now theoretically much ... [more ▼]

Statistical theories of mass spectra are based on two assumptions. The first one, which postulates efficient phase space sampling, is substantiated by various experimentation and is now theoretically much better understood. The efficiency of phase space sampling can be estimated and is found to be quite good. Much effort remains to be done concerning the second assumption. A new impetus should be given to the concept of transition state. A better understanding of the role played by the conservation of angular momentum, the exact significance of transition state switching, and the incorporation of quantum effects are set as goals for the future. © 2000 Elsevier Science B.V. [less ▲]

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See detail. Modulation of the biological action of bovine growth hormone by passive immunization in hypophysectomised rat
Jacqmin, Sandrine; Vleurick, Lieve; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 3

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See detailDétermination des puissances spécifiques critiques dans des rivières à charge de fond caillouteuse
Petit, François ULg; Perpinien, G.; Deroanne, Claude ULg

in Revue Géographique de l'Est (2000)

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See detailFeed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins.
Renaville, Robert ULg; Van Eenaeme, Christian ULg; Breier, B. H. et al

in Domestic Animal Endocrinology (2000), 18(2), 165-76

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA ... [more ▼]

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA) and western ligand blotting (WLB) methods for bovine IGFBP-2. Twelve prepubertal 290 d-old Belgian Blue bulls (mean weight: +/- 290 kg) were randomly assigned in three groups: a control group (NG; n = 4) receiving a classic fattening diet to induce "normal" growth (1.48 kg/d), a feed restricted group (RG; n = 4) to obtain reduced growth (0.50 kg/d) and, a severely restricted group (SG; n = 4) to nearly stop growth (0.08 kg/d). The feed restriction period was maintained over a period of 114 d. After the period of differential feeding, all animals received the control feed regime over a period of 100 d. Blood samples were collected at fortnightly intervals. Circulating IGF-I was measured by RIA whereas plasma IGFBPs was evaluated by WLB; IGFBP-2 was additionally quantified by RIA procedure. At the beginning of the trial, IGF-I levels were low (<100 ng/ml) and similar in the three groups in accordance with prepubertal status. In the NG group, a progressive rise in IGF-I was observed from Day 42 to Day 142 whereas in the RG and SG groups, IGF-I levels did not change until the experimental restriction period ended. The delay of the rise in plasma IGF-I was longer for the SG group, IGF-I remained low until 2 wk after the end of the period of restricted feeding. Surprisingly, although differences were detected for IGF-I levels between the three groups, the IGFBP-2 and -3 data, evaluated by WLB could only discriminate between NG and SG group and not between NG and RG. However, by using a RIA method, an IGFBP-2 decrease was observed in the NG group coincident with increasing IGF-I levels. For both RG and SG groups, IGFBP-2 levels remained high throughout the feed restriction period whereas plasma IGFBP-2 levels declined upon feeding in both groups. During this feed restriction period, IGFBP-2 was significantly lower in NG than in RG or SG groups. Moreover, SG group animals had higher levels in plasma IGFBP-2 than RG animals. In conclusion, puberty is characterized by developmental changes in plasma IGF-I and IGFBPs that were altered by feed restriction. Moreover, RIA evaluation of plasma IGFBP-2 is able to better reflect group differences than WLB. [less ▲]

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See detailEvaluation thérapeutique précoce par tomographie à émission de positons
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Médecine et Hygiène (2000), 58

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See detailThe role of lateral occipitotemporal junction and area MT/V5 in the visual analysis of upper-limb postures
Peigneux, Philippe ULg; Salmon, Eric ULg; Van der Linden, Martial ULg et al

in Neuroimage (2000), 11(6), 644-655

Humans, like numerous other species, strongly rely on the observation of gestures of other individuals in their everyday life. It is hypothesized that the visual processing of human gestures is sustained ... [more ▼]

Humans, like numerous other species, strongly rely on the observation of gestures of other individuals in their everyday life. It is hypothesized that the visual processing of human gestures is sustained by a specific functional architecture, even at an early prelexical cognitive stage, different from that required for the processing of other visual entities. In the present PET study, the neural basis of visual gesture analysis was investigated with functional neuroimaging of brain activity during naming and orientation tasks performed on pictures of either static gestures (upper-limb postures) or tridimensional objects. To prevent automatic object-related cerebral activation during the visual processing of postures, only intransitive postures were selected, i.e., symbolic or meaningless postures which do not imply the handling of objects. Conversely, only intransitive objects which cannot be handled were selected to prevent gesture-related activation during their visual processing. Results clearly demonstrate a significant functional segregation between the processing of static intransitive postures and the processing of intransitive tridimensional objects. Visual processing of objects elicited mainly occipital and fusiform gyrus activity, while visual processing of postures strongly activated the lateral occipitotemporal junction, encroaching upon area MT/V5, involved in motion analysis. These findings suggest that the lateral occipitotemporal junction, working in association with area MT/V5, plays a prominent role in the high-level perceptual analysis of gesture, namely the construction of its visual representation, available for subsequent recognition or imitation. (C) 2000 Academic Press. [less ▲]

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See detailL'impact de l'introduction des contrats d'options sur la Bourse de Bruxelles
Corhay, Albert ULg; Tourani-Rad, Alireza

in Cahiers Economiques de Bruxelles (2000), (166), 109-130

L'objectif de cette étude est de déterminer l'impact de la création et de l'émission de contrats d'options sur les caractéristiques des actions de la Bourse de Bruxelles. Deux types d'analyse, l'analyse ... [more ▼]

L'objectif de cette étude est de déterminer l'impact de la création et de l'émission de contrats d'options sur les caractéristiques des actions de la Bourse de Bruxelles. Deux types d'analyse, l'analyse événementielle et l'analyse économétrique des séries chronologiques individuelles utilisant notamment un modèle GARCH, sont utilisés. Tous deux aboutissent à la même conclusion. Les résultats montrent qu'il n'existe pas de tendance générale commune à l'ensemble des titres pour ce qui concerne leur rendement et leur volatilité et que très peu de coefficients mesurant l'impact sur ces derniers sont statistiquement significatifs. Seul le volume de transaction des titres apparaît être affecté positivement par l'émission de contrats d'option. [less ▲]

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See detailThe Inferior Non Recurrent Laryngeal Nerve: A Major Surgical Risk During Thyroidectomy
Defechereux, Thierry ULg; Albert, V.; Alexandre, j et al

in Acta Chirurgica Belgica (2000), 100(2, Mar-Apr), 62-7

It is now widely established that systematic intraoperative location and diligent dissection of the recurrent inferior laryngeal nerve during thyroidectomy are the keystones to assure its anatomic and ... [more ▼]

It is now widely established that systematic intraoperative location and diligent dissection of the recurrent inferior laryngeal nerve during thyroidectomy are the keystones to assure its anatomic and functional preservation. The possibility of abnormal routes, like a non-recurrent cervical course of the inferior laryngeal nerve is an additional major argument for its systematic identification to avoid surgical damage. In 2517 cervicotomies performed between 1992 and 1997 for at least right thyroid lobe excision or parathyroid glands exploration, 20 cases of non recurrent laryngeal nerve were identified (0.79%). The embryological nature of such a nervous anatomical variation results originally from a vascular disorder, named arteria lusoria in which the fourth right aortic arch is abnormally absorbed, being therefore unable to drag the right recurrent laryngeal nerve down when the heart descends and the neck elongates during embryonic development. The surgeon must be aware of the possibility of a non recurrent laryngeal nerve, which arises directly from the cervical vagus and therefore represents a severe potential pitfall during thyroidectomy. Given the absence of reliable clinical symptoms and signs or investigations indicating preoperatively the possibility of a non recurrent nerve, guidelines are given to prevent intraoperatively this major surgical risk. [less ▲]

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See detailRespiratory responses of mature horses to intravenous lobeline bolus
Marlin, D. J.; Roberts, C. A.; Schroter, R. C. et al

in Equine Veterinary Journal (2000), 32(3), 200-207

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway ... [more ▼]

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway function. Some of the responses to lobeline in the pony have been reported, but the detailed time course, effect of dose, possible side effects and reproducibility associated with lobeline administration have not been described in the horse. Respiratory airflow rates and oesophageal pre s s u re were measured with a Fleisch No. 5 pneumotachometer and lightweight facemask and amicrotip pressure transducer catheter, respectively. The output of the Fleisch pneumotachometer was calibrated for flow rates up to ± 70 l/s. Seven mature horses with no clinical signs of respiratory disease were studied. Investigations were conducted to determine: (1) the responses to different doses of lobeline (0.15, 0.20, 0.25 and 0.30 mg/kg bwt) as a rapid i.v. bolus (6 horses); (2) arterial blood gases during and after lobeline administration (0.20 mg/kg bwt; 3 horses); and (3) the reproducibility of lobeline-stimulated hyperpnoea (5 horses; 2 doses of 0.20 mg/kg bwt lobeline, 15 min apart). All horses tolerated the lobeline-stimulated hyperpnoea well, although one always coughed or snorted at the onset. Mild tremor was noted following the highest dose in several horses. Apnoea of approximately 40 s was common after the hyperpnoea. Both tidal volume (VT) and frequency (fR) increased with lobeline dose. During peak hyperpnoea at a dose of 0.30 mg/kg bwt, peak inspired flow rate (PIF), peak expired flow rate (PEF) and minute ventilation (.VE) were mean ± s.e. 41 ± 5 l/s, 61 ± 10 l/s and 920 ± 99 l/min, respectively. The hyperpnoea also caused marked changes in arterial PaO2, PaCO2 and pHa at 90 s after lobeline (0.20 mg/kg bwt) administration (mean ± s.e. 146.0 ± 6.9 mmHg, 20.6 ± 0.8 mmHg and 7.707 ± 0.020, respectively) compared to at rest (mean ± s.e. 104.0 ± 4.0 mmHg, 50.6 ± 2.8 mmHg and 7.432 ± 0.012). Dynamic lung compliance (Cdyn) was unaltered by lobeline administration. The lobeline-induced hyperpnoea was highly reproducible, with no significant difference in any of the parameters during 2 stimulations 15 min apart. Lobeline induced highly reproducible responses without any apparent adverse effects and may be useful in the investigation of pulmonary function in healthy horses and those with airway disease. [less ▲]

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See detailPhase II study of docetaxel alternating with cisplatin in chemotherapy-naïve patients with advanced non-small cell lung cancer
Mattson, Karin; Vansteenkiste, Johan; Stupp, Roger et al

in Anti-Cancer Drugs (2000), 11

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See detailChronique semestrielle de droit communautaire
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux (2000)

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See detailLe dosage des auto-anticorps anti-GAD et anti-IA 2: une aide au diagnostic precoce du diabete de type 1.
Luyckx, Françoise ULg; Delcourt, Sandrine ULg; Philips, Jean-Christophe ULg et al

in Revue Médicale de Liège (2000), 55(3), 169-75

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal ... [more ▼]

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal management. In that slowly progressive disease leading to severe and irreversible complications, the use of early and specific genetic, immunological and/or metabolic markers may help in the classification of diabetic patients and in the orientation of therapeutic strategies; furthermore, it is also an essential aid in the early screening of subjects at risk of developing the disease. The assessment of classical immunological markers, such as islet cell antibodies (ICA) or anti-insulin antibodies (IAA) has been recently completed by the screening of new promising markers such as GAD- and IA2-antibodies. The presence of these markers confirms the autoimmune component of the disease and thus supports the diagnosis of type 1 diabetes, even if clinical symptoms are absent or inconsistent. In addition, it represents a strong argument in favour of the initiation of specific immunological therapies to preserve B-cell number and function. [less ▲]

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See detailField observations on the variability of crude oil impact on indigenous hydrocarbon-degrading bacteria from sub-Antarctic intertidal sediments
Delille, Daniel; Delille, Bruno ULg

in Marine Environmental Research (2000), 49(5), 403-417

Oil pollution of the oceans has been a problem ever since man began to use fossil fuels. Biodegradation by naturally occurring populations of micro-organisms is a major mechanism for the removal of ... [more ▼]

Oil pollution of the oceans has been a problem ever since man began to use fossil fuels. Biodegradation by naturally occurring populations of micro-organisms is a major mechanism for the removal of petroleum from the environment. To examine the effects of crude oil pollution on intertidal bacteria, we repeated the same contamination experiments on nine different sub-Antarctic intertidal beaches using specifically built enclosures (PVC pipe, 15 cm in inner diameter and 30 cm in height). Despite the pristine environmental conditions, significant numbers of indigenous hydrocarbon-degrading bacteria were observed in all the studied beaches. Introduction of oil into these previously oil-free environments resulted in several orders of magnitude of increase in hydrocarbon-degrading micro-organisms within a few days in some of the studied sites but has no obvious effects on two others. The physical environment of the bacterial assemblage seems to play a major role in the biodegradation capacities. After 3 months of contamination, both remaining oil concentrations and biodegradation indexes differ strongly between the different stations. Thus, chemical and biological parameters reveal a strong heterogeneity of biodegradation capacities between the different sites. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPsychiatrie en osteoporose
Halkin, V; Reginster, Jean-Yves ULg

in Agenda Psychiatrie (L') (2000), 14

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See detailBoundedness properties for time-varying nonlinear systems
Peuteman, Joan; Aeyels, Dirk; Sepulchre, Rodolphe ULg

in SIAM Journal on Control & Optimization (2000), 39(5), 1408-1422

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See detailRisedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group.
Fogelman, I; Ribot, C; Smith, R et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(5), 1895-900

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months ... [more ▼]

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months of placebo or risedronate (2.5 or 5 mg/day). All received calcium (1 g/day). The principal outcome measures were bone mineral density (BMD) at the lumbar spine, femoral neck, and femoral trochanter. At 24 months, lumbar spine BMD increased from baseline by 4% with 5 mg risedronate and 1.4% in the 2.5-mg group, compared with no change with placebo. Efficacy was similar in women who were less than 5 yr and more than 5 yr postmenopausal. At 24 months, risedronate (5 mg) had also increased BMD at the femoral neck and trochanter, whereas BMD decreased in the placebo group. BMD increases were seen at all three sites with risedronate (5 mg) after only 6 months of therapy. Risedronate was well tolerated; upper gastrointestinal adverse events were similar to placebo. We conclude that risedronate (5 mg) increases BMD rapidly and effectively and is well tolerated in postmenopausal women with low bone mass, regardless of time since menopause. [less ▲]

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See detailLe Sart Tilman et Louvain-la-Neuve
Frankignoulle, Pierre ULg

in Cahiers de l'Urbanisme (Les) (2000), 28-29

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See detailESR associated with spin-labelling methods into the study of photosensitization in liposomal solutions
Hoebeke, Maryse ULg

in Bulletin de la Société Royale des Sciences de Liège (2000)

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See detail"note sous J.P. Jumet, 19 février 1998"
Moreau, Pierre ULg

in Actualités du Droit (2000)

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See detailLe mélèze, une essence à haut potentiel de production
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(3), 6-10

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze ... [more ▼]

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze méritait, à plusieurs égards, d'être davantage prise en compte en Région wallonne et ce, pour autant qu'une sylviculture adaptée à l'essence et aux conditions du milieu soit appliquée. Les lignes qui suivent sont consacrées à des résultats originaux résultant d'une étude menée par l'Unité de Gestion et Economie forestières de la Faculté universitaire des Sciences agronomiques de Gembloux, sur la croissance des mélèzes en Région wallonne. Le potentiel de croissance du mélèze a été évalué à partir d'analyses de tiges ou de mesures réalisées au sein de placettes de production (figure 1) remesurées tous les 3 ans. A partir d'une exploitation appropriée de ces données, on a déduit une gamme de traitements sylvicoles capables de rencontrer les objectifs de production que l'essence permet d'atteindre. [less ▲]

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See detailAntiobesity pharmacotherapy in the management of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes/Metabolism Research & Reviews (2000), 16(2), 114-24

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction ... [more ▼]

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction should be considered as a key objective. In this respect, several antiobesity drugs have demonstrated potential. However, while fenfluramine and dexfenfluramine have been shown to promote weight loss and to directly improve insulin sensitivity, being two mechanisms contributing to better blood glucose control in obese Type 2 diabetic patients, they were recently withdrawn due to safety problems. Sibutramine, a new selective norepinephrine and serotonin reuptake inhibitor, promotes weight loss by decreasing food intake, an effect which leads to a mild improvement (significant in patients losing > or =5% of initial body weight) of blood glucose control in obese diabetic patients. Similarly, orlistat, a selective gastrointestinal lipase inhibitor which increases faecal fat losses, enhances diet-induced weight reduction and improves both blood glucose control and vascular risk profile, especially dyslipidaemia, in obese Type 2 diabetic patients. Further studies are required to better identify good responders to pharmacotherapy and specify the role of antiobesity agents in the overall long-term management of obese subjects with Type 2 diabetes. Other novel pharmacological approaches deserve further consideration, for instance beta-3 agonists aiming to increase energy expenditure, drugs interfering with tumor necrosis factor-alpha (TNF-alpha) or free fatty acid release by the adipose tissue or agents that slow gastric emptying. However, until now, results regarding efficacy and/or safety have been disappointing or preliminary in humans. [less ▲]

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See detailLa quittance BGU VII 1589
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (2000), LXXV(149), 111-117

BGU VII, 1589 (Philadelphia, 166/7 A.D.) in an intermediate receipt (antisymbolon). The nomographos is no tax collector.

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See detailDeletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
Herens, Christian ULg; Tassin, Françoise ULg; Lemaire, Véronique ULg et al

in British Journal of Haematology (2000), 110(1), 214-6

Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This ... [more ▼]

Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration. [less ▲]

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See detailLa sécurité des filières agro-alimentaires : de l'éthique à l'étiquette.
Sindic, Marianne ULg

in Cahiers Agricultures (2000), 9

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See detailCattle neosporosis in Belgium : a case-control study in dairy and beef cattle
De Meerscham, F.; Focant, C.; Boreux, R. et al

in International Journal for Parasitology (2000)

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See detailNutrient depletions in the Ross Sea and their relation with pigment stocks
Goeyens, Leo; Elskens, Marc; Catalano, Giulio et al

in Journal of Marine Systems (2000), 27

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises ... [more ▼]

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises in the Ross Sea, two distinct groups were recognised. The first one was characterised by moderate nutrient nitrate and silicic acid depletions in combination with relatively high diatom and Phaeocystis abundance. The second group showed very low nutrient depletions and very poor diatom abundance. Average depth specific nitrate depletions were 8.1 and 1.1 μM and average silicic acid depletions were 21.5 and 1.3 μM, respectively. The nutrient consumption patterns did not match the conditions of silicic acid excess (SEA) or nitrate excess areas (NEA), a clear trend being probably obscured by very poor seasonal maturity of several sampling stations. The contrast between both groups is largely explained by small differences in nitrogen uptake regime of the major phytoplankters. During early season, the diatoms meet the majority of their nitrogen requirements by nitrate uptake, with few exceptions where ammonium is the most important nitrogenous substrate. On average, their nitrate uptake capacity is lower than that of Phaeocystis (average specific nitrate uptake rates were 0.021 and 0.036 day y-1 for diatoms and Phaeocystis, respectively). The latter phytoplankton always shows predominance of nitrate uptake. Both groups are subject to inhibition of nitrate uptake when ammonium availability increases, and it is likely that the diatoms are more sensitive to the inhibitory effect of ammonium. [less ▲]

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See detailCroissance et rentabilité des plantations de douglas en Région wallonne.
Lejeune, Philippe ULg; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(1), 6-15

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité ... [more ▼]

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité assorti de propriétés mécaniques remarquables ( de CHAMPS et DEMACQ, 1996). Encore faut-il que le sylviculteur identifie clairement l'itinéraire sylvicole à assigner à ces peuplements sur des bases aussi objectives que possibles. Les critères devant orienter ce choix relèvent autant de l'adéquation essence-station qui est un préalable à leur installation, que des exigences du marché ou encore, dans le contexte d'une sylviculture de production, de la rentabilité financière du projet sylvicole retenu. L'objectif de la présente étude est d'évaluer de manière générale la rentabilité financière potentielle d'une plantation de douglas en Wallonie. Au travers d'une comparaison de quelques scénarios sylvicoles représentatifs des grandes tendances en matière de culture de cette essence, nous essaierons également d'apprécier l'impact du choix sylvicole, non seulement sur la rentabilité du projet, mais également sur les caractéristiques dendrométriques, voire technologiques, des peuplements ainsi façonnés. Une telle démarche de comparaison de scénarios sylvicoles implique avant tout de disposer d'un outil capable de prédire, d'une manière aussi fiable que possible, l'évolution sur plusieurs décennies de peuplements forestiers soumis à un traitement sylvicole donné. Il convient également de bien préciser la démarche retenue pour effectuer les comparaisons de rentabilité financière en insistant sur l'interprétation à donner à celles-ci. Nous présenterons tout d'abord le modèle de croissance que nous avons utilisé dans le cadre de cette étude (paragraphe 2) et préciserons les modalités d'évaluation financière mises en oeuvre (paragraphe 3). Nous détaillerons ensuite, sur base des principaux paramètres sylvicoles (révolution, densité de plantation, calendrier et nature des éclaircies), les différents scénarios considérés dans cette comparaison (paragraphe 4), ainsi que leurs performances respectives (paragraphe 5). Nous conclurons enfin sur la portée des résultats enregistrés et les limitations d'une telle étude (paragraphe 6). [less ▲]

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See detailVillers-le-Bouillet/Vaux-et-Borset : sauvetage d'une fosse néolithique au lieu-dit "A la Chapelle Blanche"
Delye, Emmanuel ULg; Delhaye, Donat; Roberti, Daniel

in Chronique de l'Archéologie Wallonne (2000), 8

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See detailBinding and release of metallic cations by a polyaniline-based resin
Jérôme, Christine ULg; Martinot, Lucien; Jérôme, Robert ULg

in Radiochimica Acta (2000), 88(1), 39-46

The electrochemical control of the binding of metallic ions (actinides and a lanthanide) by redox active polyaniline resin, i.e., polyaniline doped by polystyrene sulfonate (Pani/PSSO3), has been studied ... [more ▼]

The electrochemical control of the binding of metallic ions (actinides and a lanthanide) by redox active polyaniline resin, i.e., polyaniline doped by polystyrene sulfonate (Pani/PSSO3), has been studied. Electrochemical and nuclear techniques (cyclic voltammetry, α -counting, Rutherford backscattering) have been used in order to characterize the exchange of thorium, lanthanum and uranium cations, particularly in terms of reversibility and efficiency. This electrochemical process has been compared with the chemical one promoted merely by pH variation, and the efficiency of the two methods has been discussed for each type of cation. [less ▲]

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See detailThe Emancipation of Women in Ancient Rome
Gerkens, Jean-François ULg; Vigneron, Roger

in Revue Internationale des Droits de l'Antiquité (2000), 47

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See detailLe capital osseux : une épargne qui débute au berceau
Halkin, V; Reginster, Jean-Yves ULg

in L'agenda Pédiatrie (2000), 22

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See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

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See detailPerformance characteristics of mill rolls from graphite chromium cast iron
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Breyer, J. P.

in Stal' (2000), 1

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents ... [more ▼]

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents. The approach of Marichal Ketin to improve the rolling performances in the last finishing stands is presented. The Hi-Cr cast iron possesses excellent wear resistance due to the presence of hard chromium carbides, but its thermal conductivity and sticking properties are fairly low. A graphite precipitation could contribute to an improvement in thermal conductivity and serve as lubricant preventing sticking. The new material, called graphitic chromium iron, shows good oxidation, wear and thermal behaviour allowing its use as work roll in the last stands of the finishing section of a HSM. In the as-cast condition, graphite precipitation in high Ni and Si chromium cast iron occurs at a temperature of 950 degrees C. Moreover, the amount and volume of free graphite may be increased by secondary graphite precipitation during suitable heat treatment. [less ▲]

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See detailTraitement des myélomes réfractaires par la Thalidomide
Sautois, Brieuc ULg; Scerbo, Franca; Beguin, Yves ULg et al

in Médecine et Hygiène (2000), 58

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See detailDNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase.
Verdemato, P. E.; Brannigan, J. A.; Damblon, Christian ULg et al

in Nucleic Acids Research (2000), 28(19), 3710-8

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and ... [more ▼]

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and thermodynamic studies were carried out to obtain a model of the DNA-binding process. Nuclear magnetic resonance (NMR) studies map the DNA-binding site to helix 5, and a loop region (residues 151-160) which form the recognition helix and the 'wing' of a helix-turn-wing motif, respectively. The NMR data also suggest the absence of a large conformational change in the protein upon binding to DNA. Hence, an O:(6)-methylguanine (O:(6)meG) lesion would be inaccessible to active site nucleophile Cys146 if the modified base remained stacked within the DNA duplex. The experimentally determined DNA-binding face of Ada-C was used in combination with homology modelling, based on the catabolite activator protein, and the accepted base-flipping mechanism, to construct a model of how Ada-C binds to DNA in a productive manner. To complement the structural studies, thermodynamic data were obtained which demonstrate that binding to unmethylated DNA was entropically driven, whilst the demethylation reaction provoked an exothermic heat change. Methylation of Cys146 leads to a loss of structural integrity of the DNA-binding subdomain. [less ▲]

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See detailTreatment of diabetes in patients with severe obesity.
Scheen, André ULg

in Biomedicine & Pharmacotherapy (2000), 54(2), 74-9

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus, and weight reduction has been shown to markedly improve blood glucose control in obese ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus, and weight reduction has been shown to markedly improve blood glucose control in obese subjects with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: 1) promoting weight loss through lifestyle modifications (hypocaloric diet and exercise) and anti-obesity drugs (orlistat, sibutramine, etc.); 2) improving blood glucose control, essentially through the reduction of insulin resistance (metformin, eventually thiazolidinediones) or insulin need (alpha-glucosidase inhibitors) and, at a later stage, the correction of defective insulin secretion (sulphonylureas, repaglinide) or low circulating insulin levels (exogenous insulin); and 3) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. When morbid obesity is present, both restoring a good glycemic control and correcting associated risk factors can only be obtained through marked and sustained weight loss. This primary objective justifies more aggressive weight reduction programmes, including very low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and in well-selected patients. [less ▲]

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See detailHydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern Hemispheres
Goffart, Anne ULg; Hecq, Jean-Henri ULg

in Journal of Marine Systems (2000), 27

Preface of the 30th International Liège Colloquium on Ocean Hydrodynamics Liège, Belgium (May 4–8 1998) : Hydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern ... [more ▼]

Preface of the 30th International Liège Colloquium on Ocean Hydrodynamics Liège, Belgium (May 4–8 1998) : Hydrodynamical and ecosystem processes in ice-covered seas of the Southern and Northern Hemispheres. Issue of JMS edited by Anne Goffart and Jean-Henri Hecq. [less ▲]

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See detailDe la medecine factuelle aux recommandations therapeutiques. Epilogue.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (2000), 55(5), 476-7

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See detailThe effect of PIT tags on growth and physiology of age-0 cultured Eurasian perch Perca fluviatilis of variable size
Baras, E.; Malbrouck, C.; Houbart, M. et al

in Aquaculture (2000), 185

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See detailJeux vidéos : enjeux et leurres
Leclercq, Dieudonné ULg; Denis, Brigitte ULg

in Education-Formation (2000)

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See detailTEP et tumeurs endocrines
Rigo, Pierre ULg; Belhocine, Tarik; Hustinx, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2000), 24(5), 275-282

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les ... [more ▼]

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les tumeurs neuroendocrines, gastroentéropancréatiques et carcinoïdes, sont également analysées. Habituellement, les tumeurs différenciées ayant une faible activité métabolique et proliférative, elles ne fixent que peu le FDG. Dans l'évaluation des tumeurs endocrines, la TEP au FDG n'intervient en général pas en première intention mais elle joue un rôle complémentaire d'autres scintigraphies spécifiques. [less ▲]

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See detailInfo-congres. Recherche en diabetologie: rayonnement europeen de l'Ecole de Liege.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(10), 960-7

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See detailICPC-2-E: the electronic version of ICPC-2. Differences from the printed version and the consequences.
Okkes, I.; Jamoulle, Marc ULg; Lamberts, H. et al

in Family practice (2000), 17(2), 101-7

BACKGROUND: In 1998, ICPC-2 was published as a book. In the process of translating the book, and preparing an electronic version of chapter 10 (the actual classification), ICPC-2 proved to contain many ... [more ▼]

BACKGROUND: In 1998, ICPC-2 was published as a book. In the process of translating the book, and preparing an electronic version of chapter 10 (the actual classification), ICPC-2 proved to contain many errors and inconsistencies. Particularly, major problems were identified in the conversion between ICPC-2 and ICD-10, which could lead to major errors when used in electronic patient records. OBJECTIVES: We prepared an electronic version of chapter 10 of ICPC-2, ICPC-2-E, with all necessary corrections, to be published on the Oxford University Press web site as a part of this article. METHODS: Errors and inconsistencies were redressed, including particularly those in the con-version structure with all consequences on the level of inclusion and exclusion criteria, through a process of careful checking. RESULTS AND CONCLUSION: ICPC-2-E, the electronic version of chapter 10 of ICPC-2, is specifically to be used in an electronic patient record and for research purposes. It is to be used together with the first nine chapters of ICPC-2, since the book is indispensable to make a correct use of ICPC. [less ▲]

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See detailConception actuelle du traitement de l’arthrose
Reginster, Jean-Yves ULg; Henrotin, Yves ULg

in Revue de la Médecine Générale [=RMG] (2000), 177

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See detailNanoindentation investigation of Ti/TiN multilayers films
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Journal of Applied Physics (2000), 87(11), 7753-7757

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period ... [more ▼]

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period thickness of multilayers was decreased from 20 to 2.5 nm. Grazing x-ray reflectometry showed that the modulation of composition of Ti/TiN multilayers exists for all the period thickness considered. From nanoindentation measurements, we determined the hardness and Young's modulus of multilayers. Hardness increased with decreasing period thickness to go beyond the rule-of-mixture value for samples with period thickness of Lambda less than or equal to 5 nm. The maximum hardness, 1.6 times higher than the value obtained by the rule of mixture, is obtained for Lambda=2.5 nm. Our results are compared to a dislocation-based model previously introduced by Lehoczky. (C) 2000 American Institute of Physics. [S0021-8979(00)09411-1]. [less ▲]

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See detailSibling cannibalism in dorada under experimental conditions. I. Ontogeny, dynamics, bioenergetics of cannibalism and prey size selectivity
Baras, E.; Ndao, E.; Maxi, M. et al

in Journal of Fish Biology (2000), 57

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See detailPrincipal component analysis based on robust estimators of the covariance or correlation matrix: Influence functions and efficiencies
Croux, C.; Haesbroeck, Gentiane ULg

in Biometrika (2000), 87(3), 603-618

A robust principal component analysis can be easily performed by computing the eigenvalues and eigenvectors of a robust estimator of the covariance or correlation matrix. In this paper we derive the ... [more ▼]

A robust principal component analysis can be easily performed by computing the eigenvalues and eigenvectors of a robust estimator of the covariance or correlation matrix. In this paper we derive the influence functions and the corresponding asymptotic variances for these robust estimators of eigenvalues and eigenvectors. The behaviour of several of these estimators is investigated by a simulation study. It turns out that the theoretical results and simulations favour the use of S-estimators, since they combine a high efficiency with appealing robustness properties. [less ▲]

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See detailLimited effects of placental and pituitary growth hormone on cytokine expression in vitro
Thellin, Olivier ULg; Coumans, Bernard ULg; Devos, Sébastien ULg et al

in European Cytokine Network (2000), 11(3), 452-455

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked ... [more ▼]

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked immunosorbent assay (ELISA) and ribonuclease protection assay, and in tonsillar cells by ELISA. In addition to pituitary GH (GH-N), the placental form (GH-V), differing from pituitary GH by 13 amino acids has also been tested. Only few effects reached statistical significance and were in no case greater than 15%. Pituitary GH slightly reduced IL-5 production and stimulated IFN-gamma production. The latter effect was also observed with prolactin and could thus be induced through the prolactin receptor. It is proposed that GH has no strong effects on the parameters investigated, possibly as a result of redundancy in the cytokine network. Alternatively, effects on leukocytes are mediated by other tissues such as the liver or are clear only in response to stronger challenges. [less ▲]

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See detailDexamethasone Ester Treatment Alters Insulin-Like Growth Factor-I, Its Binding Proteins And Thyroid Status In Finishing Calves
Bertozzi, C.; Portetelle, Daniel ULg; Massart, Serge et al

in Canadian Journal of Animal Science (2000), 80(2),

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See detailSimenon critique de Simenon. Éléments pour une reconstitution de l'espace des possibles romanesques simenoniens (1938-1948)
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (2000), (12), 27-46

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See detailPerturbed Proximal Point Algorithm with Nonquadratic Kernel
Brohé, Myrana; Tossings, Patricia ULg

in Serdica Mathematical Journal (2000), 26

Let H be a real Hilbert space and T be a maximal monotone operator on H. A well-known algorithm, developed by R.T. Rockafellar, for solving the problem "To find x in H such that 0 in Tx" is the proximal ... [more ▼]

Let H be a real Hilbert space and T be a maximal monotone operator on H. A well-known algorithm, developed by R.T. Rockafellar, for solving the problem "To find x in H such that 0 in Tx" is the proximal point algorithm. Several genaralizations have been considered by several authors: introduction of a perturbation, introduction of a variable metric in the perturbed algorithm, introduction of a pseudo-metric in place of the classical regularization, ... We summarize some of these extensions by taking into account a pseudo-metric as regularization and a perturbation in an inexact version of the algorithm. [less ▲]

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See detailChronic hepatitis B therapy with lamivudine in clinical practice - Summary of the discussion
Dixon, J.; Delwaide, Jean ULg; Horsmans, Y. et al

in Acta Gastro-Enterologica Belgica (2000), 63(4), 357-358

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See detailHarcèlement moral au travail. Etat des lieux et pistes de développement.
Faulx, Daniel ULg; Geuzaine, Caroline

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2000), 37(3), 135-147

Revue théorique critique et analyse de littérature sur le harcèlement moral

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See detailParticularités de la prise en charge de l’excès pondéral chez l’adolescent : résultats d’une enquête exploratoire
Glowacz, Fabienne ULg; Bourguignon, J. P.; Born, Michel ULg

in Bulletin d’Education du Patient (2000), 19(3), 132-140

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See detailSystemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Pardutz, A.; Krizbai, I.; Multon, Sylvie ULg et al

in Neuroreport (2000), 11(14), 3071-5

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of ... [more ▼]

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine. [less ▲]

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See detailCurrent and future trends in groundwater vulnerability assessment
Gogu, Radu; Dassargues, Alain ULg

in Environmental Geology (2000), 39(6), 549-559

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have ... [more ▼]

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have failed to reach a consensus concerning the definitions of and reference terms for groundwater vulnerability assessment. Therefore, a review of vulnerability assessment and mapping methods providing a new classification system is necessary. This is focused on techniques that use the overlay and index class methods. New research challenges in vulnerability assessment are identified, especially the need for developing dynamic links between numerical models and overlay and index methods. [less ▲]

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See detail14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Lemstra, A. W.; van Meegen, M. T.; Vreyling, J. P. et al

in Neurology (2000), 55(4), 514-6

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on ... [more ▼]

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on CSF has favorable test characteristics as a premortem diagnostic tool in CJD. However, the 14-3-3 protein is a normal cellular protein expressed in various tissues, and its presence in CSF reflects extensive destruction of brain tissue as in CJD, but also in ischemic stroke and meningoencephalitis. METHODS: 14-3-3 was tested in the CSF of a prospective series of 110 consecutive patients suspected of having CJD. RESULTS: The sensitivity was 97% and the specificity was 87% in this series. False-positive results were mainly caused by stroke and meningoencephalitis. CONCLUSION: The 14-3-3 protein is a highly sensitive and specific marker for CJD when used in the appropriate clinical context. [less ▲]

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See detailFractal characterization of wide pore range catalysts: Application to Pd-Ag/SiO2 xerogels
Blacher, Silvia ULg; Heinrichs, Benoît ULg; Sahouli, Bendida et al

in Journal of Colloid & Interface Science (2000), 226(1), 123-130

Fractal analysis has been applied to characterize the structure of Pd-Ag/SiO2 catalysts dried under vacuum (150 degrees C and 12 hPa) with different concentrations of Pd-Ag, Nitrogen adsorption-desorption ... [more ▼]

Fractal analysis has been applied to characterize the structure of Pd-Ag/SiO2 catalysts dried under vacuum (150 degrees C and 12 hPa) with different concentrations of Pd-Ag, Nitrogen adsorption-desorption, mercury porosimetry, and small-angle X-ray scattering measurements have been used. The different approaches to fractal analysis and their conditions of applicability are briefly described. Results are discussed in relation to those derived previously from classical interpretations. This analysis shows that Pd-Ag/SiO2 xerogels exhibit a very open self-similar pore structure analogous to the structure of supercritically dried aerogels and that the micropore texture can be tailored by varying the silver content. (C) 2000 Academic Press. [less ▲]

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See detailHuitième campagne de fouilles à Tell Beydar
Van der Stede, Véronique ULg; Talon, Philippe

in Annales d'Histoire de l'Art et d'Archéologie (2000), XXII

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See detailExperimental gerontology in Belgium: from model organisms to age-related pathologies
Toussaint, Olivier; Baret, P. V.; Brion, J.-P. et al

in Experimental Gerontology (2000), 35(8), 901-916

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See detailProjectively Equivariant Symbol Calculus for Bidifferential Operators
Boniver, Fabien ULg

in Letters in Mathematical Physics (2000), 54(2), 83-100

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See detailDifferences in associations of familial and nutritional factors with serum lipids between boys and girls: the Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Lambert, A.

in American Journal of Clinical Nutrition (2000), 72(2), 384-8

BACKGROUND: Sex differences in the effects of genetic and environmental factors on circulating lipids have been examined mainly in adults, in whom the influences of sex steroid hormones are well known ... [more ▼]

BACKGROUND: Sex differences in the effects of genetic and environmental factors on circulating lipids have been examined mainly in adults, in whom the influences of sex steroid hormones are well known. OBJECTIVE: Our objective was to determine the effect of sex on genetic and environmental influences on serum lipids in prepubertal boys and girls. DESIGN: Children aged 6-8, 8-10, and 10-12 y (n = 1028) were selected at random in the Belgian province of Luxembourg, a region in Europe with a high prevalence of risk factors for cardiovascular disease and diabetes. Blood glucose and serum cholesterol, triacylglycerol, and insulin concentrations were measured, and anthropometric data and blood pressure were recorded. Familial data were obtained from standardized questionnaires. Nutritional status was obtained from a 3-d record. Participation was 70.3% of the primary cohort. RESULTS: Cholesterol, triacylglycerol, and insulin values were among the highest recorded in studies of children. In girls, cholesterol correlated positively with the energy density of intake of saturated fat (r = 0.13, P = 0.001), cholesterol (r = 0.11, P = 0.006), and protein (r = 0.12, P = 0.007) and negatively with the ratio of polyunsaturated to saturated fat intake (r = -0.14, P = 0.001) and the energy density of carbohydrate intake (r = -0.11, P = 0.019). In boys, no such relations were found. Triacylglycerol was not significantly related to nutritional factors. Consistent, independent relations were found between reported elevated cholesterol concentrations in the parental and grandparental generation and cholesterol (r = 0.101, P = 0.011) and triacylglycerol (r = 0.09, P = 0.03) in boys. No such associations were found in girls. CONCLUSION: Environmental and genetic factors may have different effects on serum cholesterol in girls and boys. [less ▲]

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See detailGenetics of Crohn's Disease Behaviour
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (2000), 63(4, Oct-Dec), 377-9

Crohn's disease is probably an heterogeneous entity. This heterogeneity may be linked to either genetics or environment. In particular the behaviour of the disease, i.e. the tendency to develop ... [more ▼]

Crohn's disease is probably an heterogeneous entity. This heterogeneity may be linked to either genetics or environment. In particular the behaviour of the disease, i.e. the tendency to develop stricturing and/or penetrating lesions, may be linked to the genetic background. While epidemiological and clinical data suggest the relevance of these behavioural classifications, the progresses in the characterization of the immuno-inflammatory reaction in the bowel wall shed a new light on possible candidate genes for these genetic predispositions to various Crohn's disease behaviours. Association studies an linkage analysis focusing on growth factors, metalloproteinases and their tissue inhibitors as well as cytokines may bring new interesting data in this field. [less ▲]

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See detailLe développement folliculaire chez la vache. 2. Mécanismes hormonaux au cours du cycle et du postpartum.
Drion, Pierre ULg; Beckers, Jean-François ULg; Derkenne, F. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailTropisetron in the prevention of postoperative nausea and vomiting.
Boogaerts, J G; Bardiau, Françoise ULg; Seidel, Laurence ULg et al

in Journal of Clinical Anesthesia (2000), 12(5), 402-8

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN ... [more ▼]

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN: Prospective, open, nonrandomized, observational, interventional study. SETTING: Postanesthesia care unit, and surgical wards of the University Hospital Center, Charleroi. PATIENTS: A total of 1,132 elective surgical inpatients (>15 years of age) in two separate surveys. The first prospective survey covered all surgical adult inpatients (n = 671) after various surgical procedures over a 3-month period. A new 3-month survey was performed to assess the effectiveness of the preventive measure and included another 461 patients. INTERVENTIONS: Risk factors associated with nausea and vomiting were recorded in the first survey and used to establish an antiemetic policy. This consisted in the administration of tropisetron 2 mg intravenously after anesthesia induction, if two patient-related risk factors associated with high-risk surgery and general anesthesia were present. MEASUREMENTS AND MAIN RESULTS: Nausea frequency and intensity, assessed every 4 hours using a visual analog scale (VAS), frequency and times of vomiting episodes and the need for rescue medication were recorded for 72 hours postoperatively. Nausea was experienced by 18.8% and vomiting by 9.8% of the patients in the first survey (211 high risk-patients of 671). In the second survey, 137 patients of 461, considered at high-risk received prophylactic tropisetron. The proportion of patients having nausea decreased to 11.1% (p,178 0.01) and vomiting episodes to 2.8% (p < 0.001). Twenty-six of the tropisetron-treated patients (19%) suffered subsequent postoperative nausea and vomiting (PONV). Patient satisfaction with tropisetron was high. CONCLUSION: Prophylactic tropisetron can reduce the incidence of PONV in selected high-risk inpatients undergoing various types of surgical procedures. [less ▲]

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See detailDiscordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.
Twizere, Jean-Claude ULg; Kerkhofs, Pierre; Burny, Arsène et al

in Journal of Virology (2000), 74(21), 9895-902

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second ... [more ▼]

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second function, immortalization of primary cells in vitro. These activities of Tax can be dissociated on the basis of point mutations within specific regions of the protein. For example, mutation of the phosphorylation sites at serines 106 and 293 abrogates immortalization potential in vitro but maintains transcriptional activity. This type of mutant is thus particularly useful for unraveling the role of Tax immortalization activity during leukemogenesis independently of viral replication. In this report, we describe the biological properties of BLV recombinant proviruses mutated in the Tax phosphorylation sites (BLVTax106+293). Titration of the proviral loads by semiquantitative PCR revealed that the BLV mutants propagated at wild-type levels in vivo. Furthermore, two animals (sheep 480 and 296) infected with BLVTax106+293 developed leukemia or lymphosarcoma after 16 and 36 months, respectively. These periods of time are within the normal range of latencies preceding the onset of pathogenesis induced by wild-type viruses. The phenotype of the mutant-infected cells was characteristic of a B lymphocyte (immunoglobulin M positive) expressing CD11b and CD5 (except at the final stage for the latter marker), a pattern that is typical of wild-type virus-infected target cells. Interestingly, the transformed B lymphocytes from sheep 480 also coexpressed the CD8 marker, a phenotype rarely observed in tumor biopsies from chronic lymphocytic leukemia patients. Finally, direct sequencing of the tax gene demonstrated that the leukemic cells did not harbor revertant proviruses. We conclude that viruses expressing a Tax mutant unable to transform primary cells in culture are still pathogenic in the sheep animal model. Our data thus provide a clear example of the discordant conclusions that can be drawn from in vitro immortalization assays and in vivo experiments. These observations could be of interest for other systems, such as the related human T-cell leukemia virus type 1, which currently lack animal models allowing the study of the leukemogenic process. [less ▲]

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See detailOsteoporose bij de bejaarde
Reginster, Jean-Yves ULg; Taquet, AN; Fraikin, G

in Medi-Sfeer (2000), 103

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See detailDes astres à l'atome, de l'atome aux astres
Biémont, Emile ULg

in Lettre du FNRS (2000), 41

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See detailLes xeno-oestrogènes et leur impact sur l’environnement
Meurens, F.; Delaunois, A.; Beckers, Jean-François ULg et al

in Annales de Médecine Vétérinaire (2000), 145

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See detailNew f values in neutral lead obtained by time-resolved laser spectroscopy, and astrophysical applications
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Palmeri, P. et al

in Monthly Notices of the Royal Astronomical Society (2000), 312

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See detailClinical and para-clinical tests in the routine examination of headache patients.
Friberg, L.; Sandrini, G.; Janig, W. et al

in Functional Neurology (2000), 15 Suppl 3

Para-clinical examinations in the diagnosis and treatment control of headache patients vary considerably between clinics and headache centers. Among the neurological societies in Europe there has been a ... [more ▼]

Para-clinical examinations in the diagnosis and treatment control of headache patients vary considerably between clinics and headache centers. Among the neurological societies in Europe there has been a consensus that some common procedures and recommendations should be created. In the Fall of 1998, the European Federation of Neurological Societies (EFNS) commissioned a Task Force on Neurophysiological Tests and Imaging Procedures in Headache Patients. Members of the Task Force are the present authors and we have reviewed the literature on 1) neurophysiological tests (EEG and evoked potentials), 2) autonomic nervous system and clinical tests and 3) imaging and cerebrovascular tests (X-ray, CT, MR, fMRI, PET, SPECT and transcranial Doppler). The literature was carefully evaluated with respect to validity and strength of the data. The task was to reach conclusions about each technique in the form of guidelines for clinical use. Finally, selected areas for future research will be outlined. The extensive review and the guidelines will be published by the EFNS during 2000. [less ▲]

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See detailSm-Nd isotope systematics in deep-sea sediments: clay-size versus coarser fractions
Innocent, C.; Fagel, Nathalie ULg; Hillaire-Marcel, C.

in Marine Geology (2000), 168(1-4), 79-87

Sm-Nd studies were carried out on Last Glacial and Holocene sediments from the Labrador Sea. Three grain-size fractions were analyzed for each sediment: the clay-size fraction (<2 mu m), the fine cohesive ... [more ▼]

Sm-Nd studies were carried out on Last Glacial and Holocene sediments from the Labrador Sea. Three grain-size fractions were analyzed for each sediment: the clay-size fraction (<2 mu m), the fine cohesive silts (2-10 mu m) and the coarse silts (10-63 mu m) In most cases, Sm-Nd signatures are different from one grain-size to another. In addition, different Sm-Nd signatures are derived from the clay-size fractions compared to the cohesive silt fraction, indicating that the cohesive fraction is heterogeneous and that distinct origins in terms of source-areas are implied. Silt fractions record the influence of supplies from the North American Precambrian Shield, whereas clay-size fractions (<2 mu m) are more sensitive to sedimentary input from the Eastern Basins, in relation with deep currents. Coupling Sm-Nd studies on silt and clay fractions may be a powerful tool to unravel the evolution of deep circulations versus detrital supplies. (C) 2000 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEpidemiologie, physiopathologie et traitement d'une affection frequente: tinea pedis.
Lambert, Jean-Luc ULg; Richert, Bertrand ULg; Dezfoulian, Bita ULg et al

in Revue Médicale de Liège (2000), 55(3), 161-8

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly ... [more ▼]

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly responsible for the increase of cases of tinea pedis as dermatophytes grow preferentially in warm and humid environments. The clinical aspect is affected by several factors such as the host reaction to the infection, the virulence of the infective strain, species, and some local and environmental factors. If a dermatophytosis is suspected, it is mandatory to validate the provisional diagnosis by demonstration of the fungus (by culture or/and microscopic examination) to avoid useless and expensive treatments. The new antifungal molecules are very effective, well tolerated and allow short course of therapy improving the compliance of the patient in clinical practice. Relapse of tinea pedis is very common but could be avoided by several simple preventive measures of hygiene. [less ▲]

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See detailResults of the tracer tests during the El Tremedal underground coal gasification at great depth
Pirard, Jean-Paul ULg; Brasseur, Alain; Coeme, Antoinette et al

in Fuel (2000), 79(5), 471-478

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases ... [more ▼]

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases progressively with the cumulated quantity of oxygen injected. Models based on exchange of matter between the flowing fluid and a transverse dead zone were used. Results indicate that the gasifier behaves almost like a small number of stirred tanks in series with a high level of back mixing. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailVibrational Structure and Organization of Various Self-Assembled Alkanethiol Monolayers: a HREELS Study
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Langmuir (2000), 16

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R ... [more ▼]

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R-cycloalkyl-ö-alkanethiols on different gold substrates. The HREELS data are reported as a contribution to a general effort to assess the potential of electron spectroscopies in the elucidation of structural characteristics of organic surfaces. Typical fingerprints of the thiol molecules, characteristic of their primary and secondary structure (connectivity, conformation, and order), have been found in their HREELS vibrational spectra. We have shown that when the layers are disordered, the spectra are dominated by impact-excited modes, hampering the identification of the compounds. These data have evidenced many defects in the organization of the monolayers on evaporated gold substrates. The coherent domains sizes formed by the molecules in the films have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkanethiol chain and of the immersion time in thiol solutions [less ▲]

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See detailGeochemistry of granitoids from the south Carpathians: A review
Berza, Tudor; Andar, Petre; Tatu, Mihai et al

in Anuarul Institutului Geologic al României (2000), 71

Detailed reference viewed: 46 (9 ULg)