References of "Article"
     in
Bookmark and Share    
See detailPolitique et usage des manuels scolaires en mathématiques et en sciences
Monseur, Christian ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 177-183

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailDiagnostics of the jovian aurora deduced from ultraviolet spectroscopy: Model and HST/GHRS observations
Dols, V.; Gérard, Jean-Claude ULg; Clarke, J. T. et al

in Icarus: International Journal of Solar System Studies (2000), 147(1), 251-266

A model coupling an electron energy degradation code with a detailed synthetic spectrum of the H-2 Lyman and Werner band system is used to calculate the emerging auroral ultraviolet spectra from Jupiter's ... [more ▼]

A model coupling an electron energy degradation code with a detailed synthetic spectrum of the H-2 Lyman and Werner band system is used to calculate the emerging auroral ultraviolet spectra from Jupiter's atmosphere excited by electrons with different initial energy distributions. The atmospheric model is adapted from the vertical P-T profile measured by the Galileo probe and midlatitude model hydrocarbon photochemistry. Each altitude layer, with its own gas temperature, contributes to the emergent ultraviolet spectrum and the absorbers are vertically distributed within the source region of the auroral emissions. Examples of the calculated spectra are shown to validate the synthetic spectrum and to illustrate the importance of the electron energy distribution and the vertical structure. The model is then applied to the analysis of seven HST/GHRS spectra of the 1200-1700 Angstrom region obtained with 5-Angstrom resolution at various locations in the north and south Jovian aurora. These spectra have different color ratios which characterize the energy of the precipitated electrons, although they do not have a high enough spectral resolution to permit a determination of the H-2 temperature. We find that the characteristic energy of the assumed initial Maxwellian distribution ranges between 17 and 40 keV. A clear signature of acetylene absorption is observed near 1520, 1480, and 1440 Angstrom where the C2H2 cross section shows strong absorption peaks. The acetylene column abundance overlying the emission peak varies from 0.02 to 0.2 of the methane column. A better fit is obtained for some spectra when ethane absorption is added. The C2H6 column abundance varies from 0 to 0.5 of the methane column. These changes relative to methane are presumably the result of perturbations by heat released by the fast electron thermalization and/or perturbations to the hydrocarbon chemistry resulting from the production of H atoms by the aurora, A spectrum of the Io flux tube footprint and its trailing tail shows an ultraviolet color and hydrocarbon absorption quite similar to some of the main oval spectra, This observation suggests that the electrons of the Io flux tube are energized to a few tens of keV, similar to the electron precipitated in the main ovals and polar caps. Echelle spectra between 1216 and 1220 Angstrom at 0.07 Angstrom resolution are also compared with the model fitting best the mid-resolution spectra. It is found that the effective H-2 rovibrational temperature associated with the echelle spectra are significantly higher than predicted by the mid-latitude model. A large vertical temperature gradient just above the methane homopause due to large heating by auroral precipitation is a plausible explanation for this difference. (C) 2000 Academic Press. [less ▲]

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailAffections musculaires et intolrance à l'effort. 1- Pathogénie et approche diagnostique
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

Detailed reference viewed: 110 (18 ULg)
Full Text
Peer Reviewed
See detailPerformance characteristics of mill rolls from graphite chromium cast iron
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Breyer, J. P.

in Stal' (2000), 1

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents ... [more ▼]

The main requirements for the development of a new grade for the later finishing section of the mill are : good oxidation and thermal behaviour, high wear resistance, good resistance to rolling incidents. The approach of Marichal Ketin to improve the rolling performances in the last finishing stands is presented. The Hi-Cr cast iron possesses excellent wear resistance due to the presence of hard chromium carbides, but its thermal conductivity and sticking properties are fairly low. A graphite precipitation could contribute to an improvement in thermal conductivity and serve as lubricant preventing sticking. The new material, called graphitic chromium iron, shows good oxidation, wear and thermal behaviour allowing its use as work roll in the last stands of the finishing section of a HSM. In the as-cast condition, graphite precipitation in high Ni and Si chromium cast iron occurs at a temperature of 950 degrees C. Moreover, the amount and volume of free graphite may be increased by secondary graphite precipitation during suitable heat treatment. [less ▲]

Detailed reference viewed: 48 (9 ULg)
Full Text
Peer Reviewed
See detailSurfactin and iturin A effects on Bacillus subtilis surface hydrophobicity.
Ahimou, F.; Jacques, Philippe ULg; Deleu, Magali ULg

in Enzyme & Microbial Technology (2000), 27(10), 749-754

The synthesis of extracellular molecules such as biosurfactants should have major consequences on bacterial adhesion. These molecules may be adsorbed on surfaces and modify their hydrophobicities. Certain ... [more ▼]

The synthesis of extracellular molecules such as biosurfactants should have major consequences on bacterial adhesion. These molecules may be adsorbed on surfaces and modify their hydrophobicities. Certain strains of Bacillus subtilis synthesize the lipopeptides, which exhibit antibiotic and surface active properties. In this study the high-performance liquid chromatography (HPLC) analysis of the culture supernatants of the seven B. subtilis strains, showed that the lipopeptide profile varied greatly according to the strain. Among the three lipopeptide types, only iturin A was produced by all B. subtilis strains. Bacterial hydrophobicity, evaluated by the water contact angle measurements and the hydrophobic interaction chromatography, varied according to the strain. Two strains (ATCC 15476 and ATCC 15811) showing extreme behaviors in term of hydrophobicity were selected to study surfactin and iturin A effects on bacterial hydrophobicity. The two lipopeptides modified the B. subtilis surface hydrophobicity. Their effects varied according to the bacterial surface hydrophobic character, the lipopeptide type and the concentration. Lipopeptide adsorption increased the hydrophobicity of the hydrophilic strain but decreased that of the hydrophobic. Comparison of lipopeptide effects on B. subtilis surface hydrophobicity showed that surfactin was more effective than iturin A for the two strains tested. [less ▲]

Detailed reference viewed: 50 (2 ULg)
Full Text
Peer Reviewed
See detailAffections cardiaques et intolérances à l'effort. 2-Les souffles.
Amory, Hélène ULg; Art, Tatiana ULg

in Pratique Vétérinaire Equine (2000), 32(Numéro Spécial), 79-86

Detailed reference viewed: 22 (9 ULg)
Peer Reviewed
See detailClinical Usefulness of the Mini Nutritional Assessment (Mna) Scale in Geriatric Medicine
Gazzotti, C.; Albert, Adelin ULg; Pepinster, A. et al

in Journal of Nutrition, Health & Aging (The) (2000), 4(3), 176-81

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized ... [more ▼]

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized nutritional assessment upon admission by means of the MNA scale. Design: A prospective study. Setting: A large size regional university hospital. Subjects: There were 175 patients (113 women and 62 men) with a mean age of 79.7 + 8.5 years admitted for an acute problem. Death occurred in 11 patients (6.3%). METHODS: Upon admission, demographic (age, gender, origin) and medical (disease, drugs) data were recorded for each patient; the MNA questionnaire (score: 0-30) was administered and Katz score (7-28) calculated. At hospital discharge, data included Katz score, outcome (death/survival), and destination. RESULTS: The mean MNA score was 20.5 + 5.1 and the prevalence of severe malnutrition (MNA <17) was 21.7%. Further, 48.6% of elderly were at risk of malnutrition (MNA between 17 and 24). There was no association between MNA and age or gender, but underweight was a sign of low MNA values (P <.001). MNA scores were inversely related to Katz scores at both admission and hospital discharge (P <.001). Patients originating from nursing homes had a poorer nutritional status than those living at home (MNA: 18.4 against 22.3, P <.001). The number of drugs taken per patient (5.2 + 2.8) was found to be correlated with MNA (P =.049). MNA scores were on average significantly higher (P <.001) in survivors (20.9) than in nonsurvivors (14.1). CONCLUSIONS: The study clearly demonstrates the high prevalence of malnutrition and the clinical usefulness of the MNA scale in geriatric medicine. The MNA score upon admission reflects the patient's nutritional condition, degree of autonomy (Katz score), living conditions and current treatment. It is also predictive of patient's outcome (death or survival). [less ▲]

Detailed reference viewed: 42 (3 ULg)
Peer Reviewed
See detailEfficacy and tolerability of a monophasic oral contraceptive containing ethinylestradiol and drospirenone.
Huber, J.; Foidart, Jean-Michel ULg; Wuttke, W. et al

in European Journal of Contraception & Reproductive Health Care (2000), 5(1), 25-34

To assess the contraceptive reliability, cycle control and tolerability of a new monophasic oral contraceptive containing 30 g ethinylestradiol plus 3 mg drospirenone (Yasmin, Schering AG, Berlin, Germany ... [more ▼]

To assess the contraceptive reliability, cycle control and tolerability of a new monophasic oral contraceptive containing 30 g ethinylestradiol plus 3 mg drospirenone (Yasmin, Schering AG, Berlin, Germany), it was compared with an established oral contraceptive containing 30 g ethinylestradiol plus 150 g desogestrel (Marvelon, NV Organon, Oss, The Netherlands). METHODS: A randomized, open-label, 13-cycle study was performed at 80 European centers. Contraceptive reliability, cycle control, blood pressure, body weight, the incidence of adverse events and skin condition were assessed during 13 cycles of oral contraceptive use, and at follow-up. Subjects recorded body weight on three consecutive days pretreatment and weekly thereafter. RESULTS: Of 2069 women who started the study and received the trial preparations in a ratio of 4:1 (ethinylestradiol/drospirenone, n = 1657; ethinylestradiol/desogestrel, n = 412), 1615 completed the 13 cycles plus follow-up, providing data for over 23,000 evaluable cycles. Eleven pregnancies occurred during treatment, only one of which (in the ethinylestradiol/drospirenone group) could not be ascribed to user failure or interaction with other factors. Both preparations provided effective contraception and cycle control. Pre-existing acne and seborrhea were improved and blood pressure was essentially unchanged. The two treatments differed in their effect on body weight, the difference being statistically significant. In the ethinylestradiol/drospirenone group, there was a distinct decrease over the whole treatment phase, while a subtle and less distinct decrease was documented in the ethinylestradiol/desogestrel group. CONCLUSIONS: The combination of 30 g ethinylestradiol/3 mg drospirenone provides effective oral contraception, excellent cycle control, good tolerability and a level of weight loss that may have a significant beneficial effect on compliance in women with a tendency to weight gain due to water retention. [less ▲]

Detailed reference viewed: 80 (2 ULg)
Peer Reviewed
See detailVitamines anti-oxydantes dans la prevention des maladies cardio-vasculaires. 2eme partie: le point sur les essais cliniques.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(2), 105-9

Various epidemiological studies suggested that individuals with high intake of antioxidant vitamins (E, A and C) have a better cardiovascular prognosis than subjects with relative deficiencies in such ... [more ▼]

Various epidemiological studies suggested that individuals with high intake of antioxidant vitamins (E, A and C) have a better cardiovascular prognosis than subjects with relative deficiencies in such vitamins. However, placebo-controlled randomized clinical trials did not demonstrate that a specific supplementation in either alpha-tocopherol (vitamin E) or beta-carotene (vitamin A) allows to reduce the incidence of major cardiovascular events, in the general population or even in various subgroups at high risk, and there is no such controlled trials with vitamin C alone. Some studies suggested that combined supplements of several antioxidant vitamins might be more efficacious, and these observations led to initiate several large controlled studies. Thus, until now, there is no convincing arguments in the literature in favour of artificial supplements of antioxidant vitamins. It seems preferable to encourage a well-balanced healthy diet while awaiting the results of the large prospective ongoing trials with combined supplementation. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailSeparation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.
Fillet, Marianne ULg; Bechet, Isabelle; Fotsing, Lucas ULg et al

in Biomedical Chromatography : BMC (2000), 14(1), 12-3

Separation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.

Detailed reference viewed: 19 (10 ULg)
Full Text
Peer Reviewed
See detailKantvilasia (Lecanorales, Ectolechiaceae), a new foliicolous lichen genus from Tasmania
McCarthy, P.M.; Elix, J.A.; Sérusiaux, Emmanuël ULg

in Lichenologist (2000), 32

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailGiant lymph node hyperplasia.
NCHIMI LONGANG, Alain ULg; Biquet, J. F.; Rausin, L.

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2000), 83(1), 19

Detailed reference viewed: 14 (4 ULg)
See detailL'évaluation externe en lecture menée à l'entrée en 3e secondaire : morceaux choisis
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (1-2), 7-11

En octobre 1998, une évaluation externe en lecture s'est déroulée dans un échantillon représentatif de classes de 3e année de l'enseignement secondaire en Communauté française de Belgique. A cette ... [more ▼]

En octobre 1998, une évaluation externe en lecture s'est déroulée dans un échantillon représentatif de classes de 3e année de l'enseignement secondaire en Communauté française de Belgique. A cette occasion, on a non seulement évalué dans quelle mesure les élèves maîtrisent certaines des compétences essentielles reprises dans les socles, mais aussi tenté de comprendre les rapports complexes que les adolescents entretiennent avec le monde de l'écrit. [less ▲]

Detailed reference viewed: 56 (14 ULg)
Full Text
Peer Reviewed
See detailThe Topology Of Lysine-Containing Amphipathic Peptides In Bilayers By Circular Dichroism, Solid-State Nmr, And Molecular Modeling
Vogt, B.; Ducarme, P.; Schinzel, S. et al

in Biophysical Journal (2000), 79(5), 2644-56

In order to better understand the driving forces that determine the alignment of amphipathic helical polypeptides with respect to the surface of phospholipid bilayers, lysine-containing peptide sequences ... [more ▼]

In order to better understand the driving forces that determine the alignment of amphipathic helical polypeptides with respect to the surface of phospholipid bilayers, lysine-containing peptide sequences were designed, prepared by solid-phase chemical synthesis, and reconstituted into membranes. CD spectroscopy indicates that all peptides exhibit a high degree of helicity in the presence of SDS micelles or POPC small unilamellar vesicles. Proton-decoupled (31)P-NMR solid-state NMR spectroscopy demonstrates that in the presence of peptides liquid crystalline phosphatidylcholine membranes orient well along glass surfaces. Thenorientational distribution and dynamics of peptides labeled with (15)N at selected sites were investigated by proton-decoupled (15)N solid-state NMR spectroscopy. Polypeptides with a single lysine residue adopt a transmembrane orientation, thereby locating this polar amino acid within the core region of the bilayer. In contrast, peptides with > or = 3 lysines reside along the surface of the membrane. With 2 lysines in the center of an otherwise hydrophobic amino acid sequence the peptides assume a broad orientational distribution. The energy of lysine discharge, hydrophobic, polar, and all other interactions are estimated to quantitatively describe the polypeptide topologies observed. Furthermore, a molecular modeling algorithm based on the hydrophobicities of atoms in a continuous hydrophilic-hydrophobic-hydrophilic potential describes the experimentally observed peptide topologies well. [less ▲]

Detailed reference viewed: 23 (0 ULg)
Full Text
Peer Reviewed
See detailThe influence of facial emotion displays gender, and ethnicity on judgments of dominance and affiliation
Hess, U; Blairy, Sylvie ULg; Kleck, R

in Journal of Nonverbal Behavior (2000), 24(4), 265-283

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailAffections musculaires et intolérance à l'effort. 2- Traitement
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intole¬rance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intole¬rance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

Detailed reference viewed: 146 (20 ULg)
See detailLa mémoire de travail : une approche neuropsychologique et par imagerie cérébrale
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Thérapie (2000), 55(4), 455-460

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible ... [more ▼]

The working memory model proposed by Baddeley and Hitch has frequently been used in cognitive psychology and neuropsychological studies. This model consists of several interacting components, responsible for the storage and processing of the information stored in working memory. Many neuropsychological and functional imagery data are consistent with that formulation of working memory. Moreover, many cognitive tasks have been specifically designed to explore particular aspects of working memory functioning. Taken as a whole, these data confirm that the working memory model remains a useful theoretical framework to explore memory functioning both in normal subjects and in pathological conditions. [less ▲]

Detailed reference viewed: 23 (6 ULg)
Full Text
Peer Reviewed
See detailAn Appraisal of 18-Fluorodeoxyglucose Positron Emission Tomography for Melanoma Staging
Paquet, Philippe ULg; Henry, Frédérique ULg; Belhocine, Tarik et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2000), 200(2), 167-9

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To ... [more ▼]

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To compare the diagnostic performance of 18-FDG PET scan to that of conventional imaging. METHODS: A total of 28 assessments were conducted in 24 patients at risk of metastatic MM. Results: The diagnostic accuracy was over 80% and similar for PET scan and conventional imaging. CONCLUSION: Both the specificity and sensitivity of PET scan are high although not perfect. Confrontation of data with anatomical location and clinicopathological findings remains mandatory. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Peer Reviewed
See detailErgotamine in the acute treatment of migraine: a review and European consensus.
Tfelt-Hansen, P.; Saxena, P. R.; Dahlof, C. et al

in Brain : A Journal of Neurology (2000), 123 ( Pt 1)

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe ... [more ▼]

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe reviewed the pre-clinical and clinical data on ergotamine as it relates to the treatment of migraine. From this review, specific suggestions for the patient groups and appropriate use of ergotamine have been agreed. In essence, ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions. For most migraine sufferers requiring a specific anti-migraine treatment, a triptan is generally a better option from both an efficacy and side-effect perspective. [less ▲]

Detailed reference viewed: 31 (2 ULg)
Peer Reviewed
See detailFollicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells.
Tsunoda, R.; Heinen, Ernst ULg; Sugai, N.

in Cell & Tissue Research (2000), 299(3), 395-402

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular ... [more ▼]

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular dendritic cells (FDC) are capable of regulating the susceptibility to apoptosis of GC B cells, we constructed a GC model in vitro: emperipolesis of tonsillar B cells by FDC. We then analyzed the expressions of apoptosis-related proteins (Bcl-2 and Fas) on the cells by three-color flow cytometry. B cells nonentrapped by FDC decreased rapidly in number owing to early apoptosis in vitro, whereas entrapped B cells were rescued for at least 18 h and showed peculiar regulation of Fas and Bcl-2. GC founder cells (CD38+, IgD+; GCFC) and GC B cells (CD38+, IgD-) showed approximately a twofold increased expression of Fas; in contrast, mantle zone B cells (CD38-, IgD+) and memory B cells (CD38-, IgD-) showed no changes. Bcl-2 expression in mantle zone and memory B cells was reduced by approximately one-half; however, GCFC and GC B cells continued to express little Bcl-2 and this did not change. Our findings strongly suggest that FDC play a part in the modulation of the susceptibility to apoptosis on B cells within GC. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Peer Reviewed
See detailQui gagnera la bataille des triptans ?
Schoenen, Jean ULg

in Médi Sphère (2000), (Fév/Mars), 17-18

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailPolymer-layered silicate nanocomposites: preparation, properties and uses of a new class of materials
Alexandre, Michaël ULg; Dubois, Philippe ULg

in Materials Science & Engineering. R: Reports (2000), R28(1-2), 1-63

A review with 115 refs. This review aims at reporting on very recent developments in syntheses, properties and (future) applications of polymer-layered silicate nanocomposites. This new type of materials ... [more ▼]

A review with 115 refs. This review aims at reporting on very recent developments in syntheses, properties and (future) applications of polymer-layered silicate nanocomposites. This new type of materials, based on smectite clays usually rendered hydrophobic through ionic exchange of the sodium interlayer cation with an onium cation, may be prepd. via various synthetic routes comprising exfoliation adsorption, in situ intercalative polymn. and melt intercalation. The whole range of polymer matrixes is covered, i.e., thermoplastics, thermosets and elastomers. Two types of structure may be obtained, namely intercalated nanocomposites where the polymer chains are sandwiched in between silicate layers and exfoliated nanocomposites where the sepd., individual silicate layers are more or less uniformly dispersed in the polymer matrix. This new family of materials exhibits enhanced properties at very low filler level, usually inferior to 5 wt.%, such as increased Young's modulus and storage modulus, increase in thermal stability and gas barrier properties and good flame retardancy. [on SciFinder (R)] [less ▲]

Detailed reference viewed: 73 (0 ULg)
See detailLa réforme grégorienne et les tentatives de réforme du calendrier grégorien
Biémont, Emile ULg

in Bulletin de liaison du Département d'Etudes grecques, latines et Orientales de l'Université de Louvain (2000), 11

Detailed reference viewed: 14 (1 ULg)
Peer Reviewed
See detailGenes upregulated during castration-induced rat prostatic apoptosis: cloning and characterization of new cDNAs.
Bruyninx, M.; Ammar, H.; Reiter, E. et al

in BJU International (2000), 85(9), 1134-42

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day ... [more ▼]

OBJECTIVE: To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS: Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybridized to confirm the positive regulation of the candidates and to follow the change in their expression in the involuting rat prostate, and in thymocytes of dexamethazone-treated rats. RESULTS: Five cDNAs were cloned: one encoding ribosomal protein L7, one coding for the insulin-like growth factor binding protein-3 (IGFBP-3), and three whose products are unknown. After castration, all five genes had expression kinetics that closely paralleled the proportion of prostatic epithelial cells undergoing apoptosis. The gene encoding L7 and two of the unknown genes were also upregulated in glucocorticoid-induced programmed death in thymocytes. In addition to the IGFBP-3 gene, those coding for proteins IGFBP-4, -5 and -6 were also overexpressed in the involuting prostate of androgen-deprived rats. CONCLUSION: Five new genes were identified that are up-regulated during castration-induced rat prostate apoptosis, three of which are potentially involved in the common intracellular pathway leading to programmed cell death. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailTreatment of diabetes in patients with severe obesity.
Scheen, André ULg

in Biomedicine & Pharmacotherapy (2000), 54(2), 74-9

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus, and weight reduction has been shown to markedly improve blood glucose control in obese ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus, and weight reduction has been shown to markedly improve blood glucose control in obese subjects with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: 1) promoting weight loss through lifestyle modifications (hypocaloric diet and exercise) and anti-obesity drugs (orlistat, sibutramine, etc.); 2) improving blood glucose control, essentially through the reduction of insulin resistance (metformin, eventually thiazolidinediones) or insulin need (alpha-glucosidase inhibitors) and, at a later stage, the correction of defective insulin secretion (sulphonylureas, repaglinide) or low circulating insulin levels (exogenous insulin); and 3) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. When morbid obesity is present, both restoring a good glycemic control and correcting associated risk factors can only be obtained through marked and sustained weight loss. This primary objective justifies more aggressive weight reduction programmes, including very low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and in well-selected patients. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Peer Reviewed
See detailChanging dynamics of the Loire river in Burgundy (France) during the last 200 years
Leteinturier, B.; Engels, Patrick ULg; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2000)

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailSpectroscopic properties of protochlorophyllide analyzed in situ in the course of etiolation and in illuminated leaves
Schoefs, B.; Bertrand, M.; Franck, Fabrice ULg

in Photochemistry & Photobiology (2000), 72(1), 85-93

The spectroscopic properties of photoactive (ie. flash-transformable) and nonphotoactive protochlorophyll(ide)s (Pchl(ide)) were reinvestigated during the development of bean leaves in darkness. Two ... [more ▼]

The spectroscopic properties of photoactive (ie. flash-transformable) and nonphotoactive protochlorophyll(ide)s (Pchl(ide)) were reinvestigated during the development of bean leaves in darkness. Two phases in the process of Pchl(ide) accumulation were apparent from quantitative measurements of pigment content: a lag phase (first week) during which photoactive Pchl(ide) accumulated faster than nonphotoactive Pchl(ide); and a fast phase (second week), showing parallel accumulation of both types of Pchl(ide). 'Flashed-minus-dark' absorbance difference spectra recorded in situ at 77 K showed that P650-655 was the predominant form of photoactive protochlorophyllide regardless of developmental stage. Quantitative analysis of energy migration processes between the Pchl(ide) forms showed the existence of energy transfer units containing a 1:8 ratio of nonphotoactive and photoactive Pchl(ide)s during development. Gaussian deconvolution of in situ 77 K fluorescence spectra indicated that the 633 nm band of nonphotoactive Pchl(ide) was made of four bands, at 625, 631, 637 and 643 nm, whose relative amplitudes only slightly changed during development. The emission band of photoactive Pchlide was also analyzed using the same method. Three components were found at 644, 652 and 657 nm, The emission band of P650-655 included the last two components, which become predominant only in fully etiolated plants. Photoactive Pchlide with an emission maximum at 653 nm was detected in the light during development of leaves of photoperiodically grown plants. [less ▲]

Detailed reference viewed: 6 (1 ULg)
Full Text
Peer Reviewed
See detailLa commission d'hemovigilance du CHU.
Baudoux, Etienne ULg; Blaffart, Francine ULg; Bouffioux, Christian ULg et al

in Revue Médicale de Liège (2000), 55(9), 878-80

As suggested by the National Blood Council, a Hemovigilance Committee was set up in the University Hospital of Liege in 1995. A multidisciplinary discussion takes place on any action aiming at the ... [more ▼]

As suggested by the National Blood Council, a Hemovigilance Committee was set up in the University Hospital of Liege in 1995. A multidisciplinary discussion takes place on any action aiming at the improvement of transfusion safety, and the follow-up of its implementation. The first issue to be discussed was the set up of a detailed documentation of all blood transfusions. The data are now recorded on a single document allowing proper identification of people and products involved, and of the eventual incidents. This document has lead to a better transfusion safety and to an improved administrative management of blood transfusion. The Commission has been coordinating two multi-centric studies analyzing the consumption of fresh blood products and the incidence of transfusion reactions. Among blood-saving policies, autologous transfusion and volume reduction of samples drawn for laboratory purposes have been discussed. Other measures were taken to improve the labeling of samples for cross-mach and to actively follow-up transfusion reactions. By its actions and advises, the Commission aims to direct strategies towards a safe and rational use of blood products. [less ▲]

Detailed reference viewed: 216 (34 ULg)
Full Text
Peer Reviewed
See detailSimulated And Measured Coefficients Of Variation For The Spray Distribution Under A Static Spray Boom
Debouche, Charles ULg; Huyghebaert, B.; Mostade, O.

in Journal of Agricultural Engineering Research (2000), 76(4), 381-388

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with ... [more ▼]

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with collecting cylinders. The second method consisted of numerical simulation of the distribution, by combining the real distributions of a number of nozzles. The real distribution was measured on a classic patternator for each nozzle separately. The numerical simulation is computerized and automated. This system allows both time and labour gains, and permits multiple trials with the same series of nozzles. Numerical simulation results are compared with spray distributions obtained on the patternator. The sprayed volumes of liquid were found to be significantly different from the simulated ones (level of significance 95%). However, the coefficient of variation characterizing the homogeneity of the spread volumes can be calculated using simulated volumes. This can be done once an empirical linear relation is established between the coefficients of variation obtained from simulated volumes and the ones obtained from measured volumes. [less ▲]

Detailed reference viewed: 29 (1 ULg)
Peer Reviewed
See detailRole of Tir and Intimin in the Virulence of Rabbit Enteropathogenic Escherichia coli (REPEC) Serotype O103:H2
Marchès, O.; Nougayrede, J. P.; Boullier, S. et al

in Infection and Immunity (2000), 68

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailEffects Of Multinutrient Blocks And Polyethylene Glycol 4000 Supplies On Intake And Digestion By Sheep Fed Acacia Cyanophylla Lindl. Foliage-Based Diets
Moujahed, Nizar; Kayouli, Chedly; Thewis, André ULg et al

in Animal Feed Science & Technology (2000), 88(3-4), 219-238

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based ... [more ▼]

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based diet. In Experiment I, six Noire de Thibar breed sheep (BW 46 kg) were used in double 3 3 Latin square design. All diets included about 360 g of dry matter (DM) of oat±vetch hay and acacia ad libitum. Diet D0 was without a block supplement. Diet D1 included a urea± molasses±mineral block (B1). While D2 included another type of block (B2) that differed from B1 essentially by adding polyethylene glycol 4000. Each experimental period lasted 33 days (21 days for adaptation and two periods of 5 days for measurement separated by 2 days for rest). Feed intake, apparent digestibility of organic matter (OM), crude protein (CP) and crude ®bre (CF) and retained nitrogen (Nr) were measured by total faecal collection. In Experiment II, four Noire de Thibar sheep (BW 53 kg) ®tted with rumen cannulae were fed sequentially D0, D1 and D2, respectively, to 90% of intake levels as measured in Experiment I on metabolic weight (MW) base. Fermentation parameters in rumen liquid (pH, NH3-N, volatile fatty acid (VFA)) were measured at 0, 2, 5, 8, 10, 13, 16 and 21 h after the morning meal. Protozoal number and composition in rumen ¯uid were determined at 2 h sampling time. Solid digesta kinetics through the rumen was measured using chromium (Cr) mordanced acacia. The DM and CP degradation of acacia was determined using the nylon bag technique. Acacia had a relatively high content of condensed tannins (41 g kgÿ1 of DM) and acid detergent lignin (176 g kgÿ1 of DM). B1 and B2 were high in CP (381 and 369 g kgÿ1 of DM, respectively) compared to acacia (127 g kgÿ1 of DM, 20% bound to ®bre) and hay (75 g kgÿ1 of DM). The two kinds of blocks improved similarly (P < 0:001) acacia DM intake by 195 g. Block 1 increased (P < 0:001) only diet CP digestibility and Nr. Block 2 increased (P < 0:05) by a low extent DM and OM digestibility compared to D1, and remarkably (P < 0:001) CP digestibility and Nr compared to D0 and D1. Block supplies considerably increased water intake. Both B1 and B2 increased (P < 0:001) NH3-N and VFA concentrations in the rumen liquid with a positive speci®c effect of B2 (PEG). VFA molar proportion was signi®cantly modi®ed by B1 and B2. B1 and B2 decreased acetate proportion and increased propionate and butyrate proportions as compared to D0 (P < 0:001). Protozoal number in rumen ¯uid was increased signi®cantly by B1 and B2 (P < 0:001). PEG-containing block (B2) increased protozoal number as compared to B1. Both B1 and B2 increased (P < 0:001) solid out¯ow rate, with a speci®c increasing effect of B2 (D2) when compared to B1 (D1). Blocks supply did not modify in situ DM degradability of acacia, but B2 improved (P < 0:05) effective degradability of CP when compared to D0 and D1 which were similar. It is concluded that both B1 and B2 improved the nutritive value of acacia-based diet. A further positive effect was noted in D2 (PEG), especially for N metabolism. [less ▲]

Detailed reference viewed: 147 (3 ULg)
Full Text
Peer Reviewed
See detailLe paradoxe du passage a l'acte: l'agressivité n'est pas la violence
Dozot, Jean-Paul; Triffaux, Jean-Marc ULg; Wauthy, Jacques ULg et al

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2000), 2

Detailed reference viewed: 169 (9 ULg)
Full Text
Peer Reviewed
See detailKinetic and spectroscopic characterization of native and metal-substituted beta-lactamase from Aeromonas hydrophila AE036.
Hernandez Valladares, M.; Kiefer, M.; Heinz, U. et al

in FEBS letters (2000), 467(2-3), 221-5

Two metal ion binding sites are conserved in metallo-beta-lactamase from Aeromonas hydrophila. The ligands of a first zinc ion bound with picomolar dissociation constant were identified by EXAFS ... [more ▼]

Two metal ion binding sites are conserved in metallo-beta-lactamase from Aeromonas hydrophila. The ligands of a first zinc ion bound with picomolar dissociation constant were identified by EXAFS spectroscopy as one Cys, two His and one additional N/O donor. Sulfur-to-metal charge transfer bands are observed for all mono- and di-metal species substituted with Cu(II) or Co(II) due to ligation of the single conserved cysteine residue. Binding of a second metal ion results in non-competitive inhibition which might be explained by an alternative kinetic mechanism. A possible partition of metal ions between the two binding sites is discussed. [less ▲]

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailSimultaneous measurements of thermal diffusivity, thermal conductivity and thermopower with application to copper and ceramic superconductors
Bougrine, Hassan ULg; Geys, J. F.; Dorbolo, Stéphane ULg et al

in European Physical Journal B -- Condensed Matter (2000), 13(3), 437-443

A home made experimental set-up allows us to measure the thermal conductivity, the thermopower and the thermal diffusivity simultaneously in the temperature range (20-300 K). Therefore the specific heat ... [more ▼]

A home made experimental set-up allows us to measure the thermal conductivity, the thermopower and the thermal diffusivity simultaneously in the temperature range (20-300 K). Therefore the specific heat can be deduced. The role of a radiation shield is shown to be relevant. Tests of the system are made on a 99.9% pure Cu sample and two polycrystalline cuprate ceramics for illustration. Without any complicated optimisation, the technique indicates much promise already due to its efficiency and rapidity. [less ▲]

Detailed reference viewed: 73 (13 ULg)
Full Text
Peer Reviewed
See detailMorphological comparison of the buccal apparatus in two bivalve commensal Teleostei : Encheliophis dubius and Onuxodon fowleri (Carapidae, Ophidiiformes)
Parmentier, Eric ULg; Castro-Aguirre, J. L.; Vandewalle, Pierre ULg

in Zoomorphology (2000), 120

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic ... [more ▼]

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic morphology to see whether 1) the head anatomy of both species is related to the constraints of their way of life, and 2) there are difference between these species and commensal carapids that shelter in other invertebrates. The components of their skeletons and muscles are similar, but differ in size and are arranged differently. In O. fowleri, the buccal cavity is smaller than in E. dubius, the jaws (bearing very large anterior teeth) are larger, the quadrato-mandibular joint lies further to the rear, the fibres of muscle bundles A3a, A2a and A2b are more vertical and insert higher on the neurocranium. The buccal system of O. fowleri appears better suited for ingesting food by biting and grasping. That of E. dubius seems better adapted to a feeding mechanism where sucking would have a more important role. The E. dubius head morphology is more similar to the cephalic anatomy of non-bivalve commensal species than to O. fowleri features. Diet constraints may have greater influence than the different host constraints on the head construction. A simulated backward rotation of the posterior part of the E. dubius suspensorium around the posterior joint between the hyomandibular and the neurocranium brings the jaws and the cheeks to coincide with those of O. fowleri. This model could be indicative of how structure modifications and their influences on annex pieces could in part have a role in the biodiversity. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailThe Efficacy of Two Vaccination Schemes against Experimental Infection with a Virulent Amyxomatous or a Virulent Nodular Myxoma Virus Strain
Marlier, Didier ULg; Mainil, Jacques ULg; Boucraut-Baralon, C. et al

in Journal of Comparative Pathology (2000), 122(2-3, Feb-Apr), 115-22

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An ... [more ▼]

Two types of myxomatosis vaccine are available commercially, namely, vaccine prepared from the Shope fibroma virus (SFV) and that prepared from an attenuated myxoma virus (MV) strain, e.gSG33. An experiment was designed to compare two vaccination schemes for their ability to protect rabbits against challenge with either a virulent amyxomatous MV strain or a virulent nodular MV strain. Apart from a difference in the cutaneous expression of the disease, the two challenge strains resembled each other in respect of mortality rate, naso-conjunctival shedding of virus, and tissue infection. Vaccination with SFV alone failed to prevent clinical signs, naso-conjunctival shedding or tissue infection. Vaccination with SFV followed by a booster inoculation with SG33 protected rabbits against the development of clinical signs and significantly reduced both viral shedding in naso-conjunctival exudates and viral infection of eyelids, lungs and testes; virus was, however, isolated from testes of some surviving animals. [less ▲]

Detailed reference viewed: 32 (4 ULg)
Full Text
Peer Reviewed
See detailTubal versus uterine placentation: similar HLA-G expressing extravillous cytotrophoblast invasion but different maternal leukocyte recruitment
Proll, J.; Bensussan, A.; Goffin, Frédéric ULg et al

in Tissue Antigens (2000), 56(6), 479-491

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect ... [more ▼]

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect the fetus against maternal alloimmune response and/or pathogen infections. We first addressed the question of whether HLA-G expression was dependent on maternal tissue environment by comparing uterine and ectopic tubal pregnancies. Using HLA-G-specific mAb on placental cryosections, we found by immunohistochemistry that all subtypes of extravillous cytotrophoblast similarly expressed HLA-G in pregnant tubes, demonstrating that its expression was independent of the site of implantation. We next compared by immunohistochemistry the phenotype of maternal leukocytes recruited in both pregnant tissues. In contrast to decidua, pregnant tubes were characterized firstly, by the lack of natural killer (NK) cells and of cells expressing CD94 receptor specific for HLA-E, secondly, by a prominent increase of CD8+ T cells, dendritic cells, and macrophages, the latter co-expressing the LIR1/ILT2 killer immunoglobulin-like receptor (KIR), and finally, by the presence of cells expressing LIR2/ILT4 KIR or BY55 NK receptors, known to bind to HLA-G. Such cell types may favor a unique innate defense in pregnant tubes. These observations also suggest that trophoblast HLA-G expression does not influence the recruitment of particular maternal leukocytes in pregnant tissues. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
See detailLe rôle des voies ferrées dans la mise en place des reptiles en Belgique et dans quelques terroitoires adjacents (Nord et Nord-Est de la France, Grand-Duché de Luxembourg)
Graitson, Eric ULg; Hussin, José; Parent, Georges Henri

in Naturalistes Belges (Les) (2000), 81(4), 376-395

Detailed reference viewed: 40 (2 ULg)
Peer Reviewed
See detailLe controle glycemique chez le patient diabetique. Recommandations apres les etudes DCCT et UKPDI.
Paquot, Nicolas ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (2000), 55(5), 372-5

Diabetes mellitus is a chronic disorder characterized by microvascular and cardiovascular complications that substantially increase the morbidity and mortality associated with the disease. Several studies ... [more ▼]

Diabetes mellitus is a chronic disorder characterized by microvascular and cardiovascular complications that substantially increase the morbidity and mortality associated with the disease. Several studies showed the association between the complications of diabetes and elevated blood glucose levels. Clinical trials have also demonstrated that treatment that lowers blood glucose reduces the risks of diabetic complications (mainly microvascular complications). The control of diabetes is assessed by frequent measurements of HbA1c. A reasonable goal in type 1 diabetes is a value of HbA1c < or = 7.2%. In type 2 diabetes, the optimal goal is a value of HbA1c < or = 6.5%, but a value < or = 8% seems to be an acceptable goal in these patients. [less ▲]

Detailed reference viewed: 32 (0 ULg)
Peer Reviewed
See detailChants populaires flamands (1879) als wetenschappelijke getuigenis van een vroeg individueel repertoire: een voorstudie
Peere, Isabelle ULg

in Volkskunde (2000), (4),

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known ... [more ▼]

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known folk song collection 'Chants Populaires Flamands avec les airs notés et poésies populaires diverses recueillis à Bruges' by Ad.-R. Lootens and J.M.E. Feys with novel data and on the basis of these, she sets up some new hypotheses. The writer proves that Lootens and Feys might have been relatives and that Catherine Beyaert, Lootens 's mother was, most likely, the most important source of Lootens's fielswork. Moreover, she casts a new light on the collaboration between Lootens and Feys during the realization of the manuscript. [less ▲]

Detailed reference viewed: 48 (1 ULg)
Full Text
Peer Reviewed
See detailAnnotations to the Devonian Correlation Table, B50di00: Miospore Palynology, Western Europe
Steemans, Philippe ULg

in Senckenbergiana lethaea (2000), 80(2), 759-760

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailLa pleuropneumonie contagieuse bovine
Linden, Annick ULg; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

Detailed reference viewed: 17 (2 ULg)
Peer Reviewed
See detailIdentification et caractérisation partielle d'un gène de Fasciola hepatica d'intérêt diagnostique
Bossaert, K.; Martin-Alonzo, J. M.; Ruiz de Eguino, A. D. et al

in Annales de Médecine Vétérinaire (2000), 144

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailNeurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin.
Bouilleret, V.; Schwaller, B.; Schurmans, Stéphane ULg et al

in Neuroscience (2000), 97(1), 47-58

The functional role of the calcium-binding proteins parvalbumin, calretinin, and calbindin D-28k for epileptogenesis and long-term seizure-related alterations of the hippocampal formation was assessed in ... [more ▼]

The functional role of the calcium-binding proteins parvalbumin, calretinin, and calbindin D-28k for epileptogenesis and long-term seizure-related alterations of the hippocampal formation was assessed in single- and double-knockout mice, using a kainate model of mesial temporal lobe epilepsy. The effects of a unilateral intrahippocampal injection of kainic acid were assessed at one day, 30 days, and four months post-injection, using various markers of GABAergic interneurons (GABA-transporter type 1, GABA(A)-receptor alpha1 subunit, calretinin, calbindin D-28k, somatostatin, and neuropeptide Y). Parvalbumin-deficient, parvalbumin/calbindin-deficient, and parvalbumin/calretinin-deficient mice exhibited no difference in cytoarchitecture of the hippocampal formation and in the number, distribution, or morphology of interneurons compared to wild-type mice. Likewise, mutant mice were not more vulnerable to acute kainate-induced excitotoxicity or to long-term effects of recurrent focal seizures, and exhibited the same pattern of neurochemical alterations (e.g., bilateral induction of neuropeptide Y in granule cells) and morphogenic changes (enlargement and dispersion of dentate gyrus granule cells) as wild-type animals. Quantification of interneurons revealed no significant difference in neuronal vulnerability among the genotypes.These results indicate that the calcium-binding proteins investigated here are not essential for determining the neurochemical phenotype of interneurons. Furthermore, they are not protective against kainate-induced excitotoxicity in this model, and do not appear to modulate the overall level of excitability of the hippocampus. Finally, seizure-induced changes in gene expression in granule cells, which normally express high levels of calcium-binding proteins, apparently were not affected by the gene deletions analysed [less ▲]

Detailed reference viewed: 22 (6 ULg)
Peer Reviewed
See detailMeasurements of the ground state ionization energy and wavelengths for the nl-nl' transitions of Ni XIX (n=4-15) and Ge XXIII (n=7-9)
Biémont, Emile ULg; Magunov, A. I.; Dyakin, V. M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2000), 33

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailClinical course and predictive factors for cyclosporin-induced autologous graft-versus-host disease after autologous haematopoietic stem cell transplantation.
Baron, Frédéric ULg; Gothot, André ULg; Salmon, Jean ULg et al

in British Journal of Haematology (2000), 111(3), 745-53

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome ... [more ▼]

The administration of cyclosporin A (CyA) after autologous haematopoietic stem cell transplantation (HSCT) induces a systemic autoimmune syndrome mimicking graft-vs.-host disease (GVHD). This syndrome, termed autologous GVHD has notable anti-tumour activity in animal studies. We intended to induce autologous GVHD with CyA in patients undergoing an autologous HSCT. We prospectively studied 118 patients with miscellaneous malignancies undergoing an autologous HSCT with low-dose CyA to characterize the clinical syndrome, its frequency and clinical course, and to determine the factors affecting its incidence. Patients received CyA from d -1 through to d 28, first starting at 2 mg/kg intravenously and then orally as soon as feasible. The dose was adjusted to achieve pre-dose blood levels around 100 ng/ml. A skin biopsy was performed when a skin rash was observed. Thirty-three percent of the patients developed clinical GVHD: clinical stage 1 in 21 patients, stage 2 in seven patients, and stage 3 in three patients. Although total body irradiation (TBI) or high-dose cyclophosphamide were previously thought to be needed, autologous GVHD occurred in five out of 12 patients (42%) after a preparative regimen with high-dose melphalan alone. Autologous GVHD was significantly more frequent in patients older than 33 years, in patients who had received high doses of granulocyte-macrophage colony forming units (CFU-GM) and in those with a diagnosis of myeloid malignancy, compared with those with lymphoid malignancies or solid tumours. A significant negative association was also found with HLA-DR6. In lymphoma patients, GVHD occurred more frequently in advanced disease than in first or second complete remission (CR1-2) patients. All other factors studied were not predictive for GVHD. In conclusion, CyA-induced GVHD is reproducibly and safely induced with doses of CyA adapted to achieve blood levels around 100 ng/ml. In retrospective analysis, there was no survival advantage for patients with GVHD. Phase III trials with this approach are needed to evaluate its anti-tumoral effect. [less ▲]

Detailed reference viewed: 29 (0 ULg)
Full Text
See detailLa maladie du hêtre : catastrophe écologique ou accident de la nature.
Rondeux, Jacques ULg

in Parcs & Réserves (2000), 55(3-4), 49

Detailed reference viewed: 14 (4 ULg)
Peer Reviewed
See detailLes souches pathogènes d'Escherichia coli chez les chiens et chats : II) Données cliniques et bactériologiques sur les souches entéropathogènes
Mainil, Jacques ULg; Janssen, L.; Charlier, G. et al

in Annales de Médecine Vétérinaire (2000), 144

Detailed reference viewed: 43 (14 ULg)
See detailThe Three Gorges Dam on the Yangtze river
Lejeune, André ULg; Pirotton, Michel ULg

in Revue Géoglobe, "Mega-Projects" (2000), (10), 20-23

Detailed reference viewed: 13 (4 ULg)
Peer Reviewed
See detailInteractions between polyamine and ethylene metabolisms in a hormone autonomous sugarbeet callus
Bisbis, Badia; Kevers, Claire ULg; Dommes, Jacques ULg et al

in Journal of Plant Physiology (2000), 157(1), 24-30

In a fully habituated non-organogenic sugarbeet callus (HNO) overproducing polyamines and underproducing ethylene (in comparison with its normal hormone-dependent counterpart), the question raised about a ... [more ▼]

In a fully habituated non-organogenic sugarbeet callus (HNO) overproducing polyamines and underproducing ethylene (in comparison with its normal hormone-dependent counterpart), the question raised about a possible competition between these two metabolites for their common precursor, S-adenosyl-methionine (SAM). The experimental strategy consisted in determining the effects of exogenous polyamines and inhibitors of polyamine biosynthetic pathway on growth, polyamine accumulation and ethylene production. Exogenous putrescine or spermidine decreased polyamine contents and ethylene production. Inhibitors of the diamine putrescine biosynthesis, DFMO and DFMA, induced a reduction of both polyamine content and ethylene production with an increase of HNO callus growth. However, when a mixture of the two inhibitors was used, an increase of ethylene production was observed without any effect on growth. The inhibitors of spermidine synthase (CHA) and of SAM decarboxylase (MGBG) also decreased polyamine content and ethylene production with different effects on growth according to the concentrations used. The combination of the two inhibitors (CHA + MGBG) increased ethylene production of the HNO callus. The effect of growth regulators (auxin and cytokinin) on growth and ethylene production of HNO callus is also discussed. These results suggest that polyamines affect directly the ethylene biosynthesis. In the absence of an exogenous hormonal control, the lower ethylene metabolism of HNO callus could not be explained by a competition with polyamines for their common precursor. [less ▲]

Detailed reference viewed: 41 (1 ULg)
Peer Reviewed
See detailLe champ des études migratoires et ethniques en Belgique
Martiniello, Marco ULg

in La Revue Générale (2000), 135(10), 19-28

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailSucceeded plant regeneration from very immature embryos of Phaseolus vulgaris
Geerts, P.; Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (2000), (43), 206-207

Detailed reference viewed: 18 (0 ULg)
Full Text
Peer Reviewed
See detailHigh Resolution Electron Energy Loss Spectroscopy Investigation of the Vibrational Structure and Order of an Octadecanethiol Monolayer on Gold Substrates
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Journal of Physical Chemistry B (2000), 104

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the ... [more ▼]

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the interaction mechanisms between the electrons and these organic ultrathin films. To show the different spatial distribution of scattered electrons from dipole and impact interactions with the monolayer, angular distributions of elastic and inelastic scattered electrons were measured for various primary energies. The absolute electron scattering loss probabilities from both dipole and impact interactions were estimated for different vibrational modes. The study of these different mechanisms was first hampered by the poor order of the layers adsorbed on evaporated gold. It became therefore highly desirable to perform the experiments on a single-crystal substrate. Using Au(111) and Au(100) single crystals as substrates, it was possible to separate the spectral response from impact and dipole interacting electrons. A negative ion resonant behavior has been observed in the energy dependence of the electron scattering differential cross sections [less ▲]

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailBasic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2.
Mounier, C. M.; Luchetta, P.; Lecut, Christelle ULg et al

in European Journal of Biochemistry (2000), 267(16), 4960-9

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q ... [more ▼]

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q mutant prolong the lag time of thrombin generation in human platelet-rich plasma with similar efficiency, indicating that hGIIA exerts an anticoagulant effect independently of phospholipid hydrolysis under ex vivo conditions. Charge reversal of basic residues on the interfacial binding surface (IBS) of hGIIA leads to decreased ability to inhibit prothrombinase activity, which correlates with a reduced affinity for factor Xa, as determined by surface plasmon resonance. Mutation of other surface-exposed basic residues, hydrophobic residues on the IBS, and His48, does not affect the ability of hGIIA to inhibit prothrombinase activity and bind to factor Xa. Other basic, but not neutral or acidic, mammalian secreted phospholipases A2 (sPLA2s) exert a phospholipid-independent inhibitory effect on prothrombinase activity, suggesting that these basic sPLA2s also bind to factor Xa. In conclusion, this study demonstrates that the anticoagulant effect of hGIIA is independent of phospholipid hydrolysis and is based on its interaction with factor Xa, leading to prothrombinase inhibition, even under ex vivo conditions. This study also shows that such an interaction involves basic residues located on the IBS of hGIIA, and suggests that other basic mammalian sPLA2s may also inhibit blood coagulation by a similar mechanism to that described for hGIIA. [less ▲]

Detailed reference viewed: 22 (4 ULg)
Peer Reviewed
See detailAnalysis of foodborne disease in Belgium in 1997.
Van Loock, F.; Ducoffre, G.; Dumont, J.-M. et al

in Acta Clinica Belgica (2000), 55

Detailed reference viewed: 25 (4 ULg)
Full Text
Peer Reviewed
See detailRestoration of thalamocortical connectivity after recovery from persistent vegetative state
Laureys, Steven ULg; Faymonville, Marie-Elisabeth ULg; Luxen, André ULg et al

in Lancet (2000), 355(9217), 1790-1791

Moreover, the performance on these factors is correlated to different anterior and posterior

Detailed reference viewed: 28 (4 ULg)
Peer Reviewed
See detailÀ la recherche du Candide liégeois
Droixhe, Daniel ULg

in Australian Journal of French Studies (2000), 37(2), 127-164

Detailed reference viewed: 45 (2 ULg)
Full Text
Peer Reviewed
See detailMorphodynamisme d'un tronçon de la Loire bourbonnaise depuis le XVIIIe siècle
Leteinturier, B.; Engels, Patrick ULg; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2000)

Detailed reference viewed: 31 (15 ULg)
Full Text
See detailMotivations et apports d'une prise en charge ambulatoire pluridisciplinaire de la santé des adolescents
Bourguignon, Jean-Pierre ULg; Grignard, Sophie ULg; Glowacz, Fabienne ULg et al

in Bulletin d'Education du Patient à sa Maladie (2000), 19(3), 126-129

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils ... [more ▼]

D’importants problèmes de santé sont identifiés par les professionnels chez les adolescents. Toutefois, ces problèmes de santé ne sont que peu ou pas soulevés par les adolescents eux-mêmes car ils consultent peu à ce sujet. En particulier, ils évoquent rarement les aspects psychosociaux des problèmes auxquels ils sont confrontés. Ils fonctionnent dans le clivage entre somatique et psychologique bien que ces deux aspects soient indissociables. Les adolescents sont souvent amenés en consultation par d’autres, dont les parents. Un travail d’identification de la demande réelle de l’adolescent est donc nécessaire pour que celui-ci puisse se mobiliser vers une prise en charge. La confidentialité est cruciale de même que le respect de l’adolescent, ainsi que la reconnaissance de ses craintes et des limites qu’il met à l’accès aux informations par l’anamnèse et l’examen clinique. Il appartient au médecin de lire la demande de l’adolescent dans un double registre, à la fois somatique et psychique et de resituer cette demande dans le contexte de vie particulier à l’adolescent. Aussi, la lecture de la demande intégrera non seulement les problèmes invoqués par l’adolescent mais aussi ceux relevés par l’anamnèse et l’examen clinique. Une telle lecture peut prendre du temps pour les intervenants de santé mais aussi pour l’adolescent, avant qu’il n’aboutisse à l’émergence de sa demande et, dès lors, à une demande de prise en charge. Celle-ci devra parfois faire appel à une équipe spécifique et pluridisciplinaire telle que celle où collaborent les auteurs du présent article, au Centre de Santé de l’Adolescent à Liège. [less ▲]

Detailed reference viewed: 327 (35 ULg)
Full Text
Peer Reviewed
See detailSeasonal changes of pCO(2) over a subantarctic Macrocystis kelp bed
Delille, Bruno ULg; Delille, D.; Fiala, M. et al

in Polar Biology (2000), 23(10), 706-716

The partial pressure of carbon dioxide (pCO(2)), calculated from pH and total alkalinity measurements. was monitored together with chlorophyll a and bacterioplankton biomass in shallow coastal water ... [more ▼]

The partial pressure of carbon dioxide (pCO(2)), calculated from pH and total alkalinity measurements. was monitored together with chlorophyll a and bacterioplankton biomass in shallow coastal water located inside and outside a giant kelp bed (Macrocystis pyrifera) situated in the Kerguelen Archipelago, Southern Ocean. In spite of large changes over a short time-scale pCO(2) variations over the year are large and exhibit a seasonal pattern in which the different stages of the annual biological turnover are well marked. The overall pattern of pCO(2) variations is related to biological activity (development of both photosynthesis and respiration) during almost the whole year. However, physical and thermodynamical constraints exert a strong influence on pCO(2) at meso time-scale (10 days) and/or when biological activity is weak. Macrocystis acts to maintain pCO(2) below saturation almost the whole year and large undersaturations (pCO(2) as low as 20 mu atm) were observed within the kelp bed. Furthermore, primary production of Macrocystis covers a period of 8 similar to 9 months a year from winter to late summer and the kelp bed seems to favour the spring phytoplanktonic bloom. The buffer factor beta indicates that, outside the kelp bed, inorganic carbon dynamics are mainly influenced by air-sea exchange and photosynthesis without calcification. Inside the kelp bed. beta suggests calcification by the epiphytic community. [less ▲]

Detailed reference viewed: 21 (5 ULg)
Full Text
Peer Reviewed
See detailOral contraception and cardiovascular risk factors during adolescence
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in Contraception (2000)

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study ... [more ▼]

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study was conducted in 24 Belgian secondary schools. Most students (1526 adolecents aged 12-17 years) agreed to participate (participation rate: 83.6%). Smoking, physical activity habits, menarche, and OC use were assessed by a self-administered questionnaire. Total cholesterol level, blood pressure and anthropometric measurements were also measured. Fourteen per cent of mature girls (14%, n=92) were OC users. Two-thirds of them (66.3%, n=61) were taking OC which contained either gestodene or desogestrel. Blood pressure and BMI were similar for OC users and non-users. Total cholesterol level was significantly higher in OC users than in non-users (191 mg/dL versus 172 mg/dL). Logistic regression model confirmed the significant influence of OC use on total cholesterol level (OR=3.08). OC users were also often smokers (39% versus 20% for non-users). In conclusion, the present study has found significant relationship between OC use and cardiovascular risk factors i.e., high total cholesterol and smoking. The first implication is a need for further research on lipoprotein profile in young OC users. Secondly, the combined use of OC and smoking in teenagers calls for preventive actions. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailEntre science et action, le concept de réseau écologique
Mougenot, Catherine ULg; Melin, Eric ULg

in Natures Sciences Sociétés (2000), 8(3), 20-30

Le concept de réseau écologique est une notion récente. Mais à peine découvert, ne va-t-il pas produire la même confusion de sens que l'on dénonce souvent à propos de la biodiversité? Pour éclairer cette ... [more ▼]

Le concept de réseau écologique est une notion récente. Mais à peine découvert, ne va-t-il pas produire la même confusion de sens que l'on dénonce souvent à propos de la biodiversité? Pour éclairer cette question, cet article repose sur l'hypothèse que trois conceptions différentes se dessinent dans le concept de réseau écologique : protéger les espèces et leurs réseaux d'habitats, restaurer le réseau écologique au sein du paysage et planifier le réseau écologique. Ces trois conceptions construisent leur propre chemin de la science à l'action, c'est-à-dire qu'elles privilégient chacune leurs questions scientifiques, leurs ressources juridiques, leurs modes de gestion et les acteurs Impliqués, Dans ce débat, les trois conceptions que nous avons dégagées apparaissent de façon complémentaire, elles s'imbriquent l'une dans l'autre, mais aucune d'elles ne peut évacuer les autres. On peut dire que ce sont là trois façons de promouvoir la biodiversité. [less ▲]

Detailed reference viewed: 362 (25 ULg)
Full Text
Peer Reviewed
See detailCancer in Transplant Recipients
Detry, Olivier ULg; Honore, Pierre ULg; Meurisse, Michel ULg et al

in Transplantation Proceedings (2000), 32(1), 127

Detailed reference viewed: 20 (5 ULg)
Peer Reviewed
See detailDielectronic structure of 2l-1s Transitions of Multicharged Ions of Argon with nuclear charges Z = 10 - 17
Biémont, Emile ULg; Quinet, Pascal ULg; Faenov, A.Ya et al

in Physica Scripta (2000), 61

Detailed reference viewed: 10 (2 ULg)
Full Text
Peer Reviewed
See detailPhotoelectron Spectroscopy of Vinyl Bromide and Intramolecular Dynamics of the ionic B state.
Hoxha, A.; Locht, Robert ULg; Leyh, Bernard ULg et al

in Chemical Physics (2000), 256

In this paper we report the He(I) photoelectron spectrum (PES) and the threshold photoelectron spectrum (TPES) of C2H3Br. The fine structure in the first two ionic states in the He(I) spectrum is assigned ... [more ▼]

In this paper we report the He(I) photoelectron spectrum (PES) and the threshold photoelectron spectrum (TPES) of C2H3Br. The fine structure in the first two ionic states in the He(I) spectrum is assigned to progressions belonging partially to previously unobserved vibrational modes. The TPES has been measured between 9.0 and 25.0 eV, and the photon energy range of 9.8-12.0 eV has been investigated in more detail. Extensive calculations with the GAUSSIAN set of programs have been performed to help in the assignment of the observed features. Furthermore, a conical intersection between the A2A" and the B2A" states was found to take place along the C-Br stretching coordinate. Intramolecular dynamics of the B2A" state, initially prepared in the Franck-Condon region, was probed by the Fourier transform of the spectrum. The B2A" state is almost readily depleted, most probably due to a very effective internal cnversion through the conical intersection. [less ▲]

Detailed reference viewed: 53 (9 ULg)
Peer Reviewed
See detailMission du team belge au Kosovo: science et justice à la rencontre du drame humain. Premiers résultats
BEAUTHIER, Jean-Pol; Boxho, Philippe ULg; CREVECOEUR, Jean-Marie et al

in Revue de Biométrie humaine et d'Anthropologie (2000)

Detailed reference viewed: 36 (5 ULg)
Full Text
See detailLes évaluations externes en Communauté française de Belgique : quel sens donner à la mesure ?
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (1-2), 110-114

Quelles sont les origines et les modalités du dispositif d'évaluation externe mis en place en Communauté française de Belgique à partir de 1994-1995 ? Quelle(s) fonction(s) est-il supposé remplir ? L ... [more ▼]

Quelles sont les origines et les modalités du dispositif d'évaluation externe mis en place en Communauté française de Belgique à partir de 1994-1995 ? Quelle(s) fonction(s) est-il supposé remplir ? L'analyse met en évidence le paradoxe d'un dispositif institutionnel rejeté à la marge du cadre législatif et dont la définition des finalités est laissée à l'appréciation des acteurs appelés à le mettre en oeuvre. [less ▲]

Detailed reference viewed: 83 (7 ULg)
Peer Reviewed
See detailL'etude clinique du mois. L'etude HOPE, un essai clinique bicephale aux resultats contrastes.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(2), 121-4

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study, recently published in the New England Journal of Medicine, demonstrated a highly significant cardiovascular protection by an ... [more ▼]

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study, recently published in the New England Journal of Medicine, demonstrated a highly significant cardiovascular protection by an angiotensin converting enzyme inhibitor, ramipril at a dose of 10 mg/day, after a mean follow-up of 4.5 years, but not of vitamin E supplements at a dose of 400 UI/day in high-risk patients (> 55 years old) who had evidence of vascular disease (secondary prevention) or combined diabetes mellitus and another cardiovascular risk factor (primary prevention). [less ▲]

Detailed reference viewed: 86 (0 ULg)
Full Text
Peer Reviewed
See detailInduction of phenolic compounds in two cultivars of cucumber by treatment of healthy and powdery mildew-infected plants with extracts of Reynoutria sachalinensis
Daayf, Fouad; Ongena, MARC ULg; Boulanger, Renald et al

in Journal of Chemical Ecology (2000), 26

Accumulation of phenolic compounds (p-coumaric, caffeic, and ferulic acids and p-coumaric acid methyl ester) was followed in susceptible (Mustang) and tolerant (Flamingo) cucumber (Cucumis sativus ... [more ▼]

Accumulation of phenolic compounds (p-coumaric, caffeic, and ferulic acids and p-coumaric acid methyl ester) was followed in susceptible (Mustang) and tolerant (Flamingo) cucumber (Cucumis sativus) cultivars. The objective was to determine whether these compounds played a role in resistance against powdery mildew following a prophylactic treatment with Milsana (leaf extracts from the giant knot weed Reynoutria sachalinensis, polygonaceae). This treatment significantly reduced the incidence of powdery mildew in both cultivars. Phenolic compounds were extracted from leaves. In the hydrolyzed fraction containing phenolic aglycones, levels of p-coumaric, caffeic, and ferulic acids and of p-coumaric acid methyl ester increased in all treatments (with leaf extracts of R. Sachalinensis, powdery mildew, or both) except the control, one or two days after treatment. In the fraction containing free phenolics, from the tested compounds, only ferulic acid showed an increase in cv. Flamingo (tolerant), and was particularly evident following treatments. On the other hand, the amounts of hydroxycinnamic acids increased rapidly in the two cultivars following Milsana treatment, suggesting their role in disease reduction. All compounds showed antifungal activity when tetsed against common pathogens of cucumber (Botrytis cinerea, Pythium ultimum, and P. aphanidermatum), but in general methyl esters were more fungitoxic than their corresponding free acids. This study suggests that cucumber is able to release antifungal compounds that are instrumental in repressing powdery mildew infection. This response is seemingly independent from the level of genetic resistance associated with each cultivar. [less ▲]

Detailed reference viewed: 67 (0 ULg)
Full Text
Peer Reviewed
See detailAn automata-theoretic approach to branching-time model checking
Kupferman, Orna; Vardi, Moshe Y; Wolper, Pierre ULg

in Journal of the ACM (2000), 47(2), 312-360

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this ... [more ▼]

Translating linear temporal logic formulas to automata has proven to be an effective approach for implementing linear-time model-checking, and for obtaining many extensions and improvements to this verification method. On the other hand, for branching temporal logic, automate-theoretic techniques have long been thought to introduce an exponential penalty, making them essentially useless for model-checking. Recently, Bernholtz and Grumberg [1993] have shown that this exponential penalty can be avoided, though they did not match the linear complexity of non-automata-theoretic algorithms. In this paper, we show that alternating tree automata are the key to a comprehensive automata-theoretic framework for branching temporal logics. Not only can they be used to obtain optimal decision procedures, as was shown by Muller ct al., but, as we show here, they also make it possible to derive optimal model-checking algorithms. Moreover, the simple combinatorial structure that emerges from the automata-theoretic approach opens up new possibilities for the implementation of branching-time model checking, and has enabled us to derive improved space complexity bounds for this long-standing problem. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Full Text
Peer Reviewed
See detailIAA-oxidase activity and auxin protectors in nonrooting, rac, mutant shoots of tobacco in vitro
Faivre-Rampant, Odile; Kevers, Claire ULg; Gaspar, Thomas ULg

in Plant Science (2000), 153(1), 73-80

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared ... [more ▼]

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared to its wild homologue. The mutant and wild shoots showed similar peroxidase variations along the growth cycle of 21 days, but with higher levels of activity for the I ac mutant. During this growth cycle, the minimum of peroxidase activity occurred at day 14 for both tobacco whole shoots. However. this minimum of activity did not occur at the same day in the basal part of the stem, where roots may appear, of the two types of tobacco. Both mutant and wild whole shoots showed about the same IAA-oxidase activity in the fractions resulting from a gel filtration of the crude extracts through a sephadex G-100 column but differed in the degree of auxin protection. The rac shoots exhibited a very high level of auxin protectors of low molecular weight, among which chlorogenic acid. They were also characterized by eight to nine times higher level of soluble phenolics. The relationships between these biochemical aspects in relation to the absence of root formation in the me mutant are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 81 (4 ULg)
Peer Reviewed
See detailLa mesure de l'efficacite therapeutique, etape essentielle dans la medecine factuelle.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(4), 206-10

Evidence-based medicine relies on the results from clinical trials. We will describe the various modes of expression of the results (absolute risk reduction, relative risk reduction, odds ratios, number ... [more ▼]

Evidence-based medicine relies on the results from clinical trials. We will describe the various modes of expression of the results (absolute risk reduction, relative risk reduction, odds ratios, number needed to treat to avoid one event,...) and we will insist upon the clinical significance and the pitfalls in the interpretation of these various indices of therapeutic efficacy. [less ▲]

Detailed reference viewed: 35 (0 ULg)
Peer Reviewed
See detailLe dosage des auto-anticorps anti-GAD et anti-IA 2: une aide au diagnostic precoce du diabete de type 1.
Luyckx, Françoise ULg; Delcourt, Sandrine ULg; Philips, Jean-Christophe ULg et al

in Revue Médicale de Liège (2000), 55(3), 169-75

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal ... [more ▼]

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal management. In that slowly progressive disease leading to severe and irreversible complications, the use of early and specific genetic, immunological and/or metabolic markers may help in the classification of diabetic patients and in the orientation of therapeutic strategies; furthermore, it is also an essential aid in the early screening of subjects at risk of developing the disease. The assessment of classical immunological markers, such as islet cell antibodies (ICA) or anti-insulin antibodies (IAA) has been recently completed by the screening of new promising markers such as GAD- and IA2-antibodies. The presence of these markers confirms the autoimmune component of the disease and thus supports the diagnosis of type 1 diabetes, even if clinical symptoms are absent or inconsistent. In addition, it represents a strong argument in favour of the initiation of specific immunological therapies to preserve B-cell number and function. [less ▲]

Detailed reference viewed: 481 (10 ULg)
Peer Reviewed
See detailTheoretical Oscillator Strengths in Pr III and application to some CP stars
Palmeri, P.; Quinet, Pascal ULg; Frémat, Y. et al

in Astrophysical Journal Supplement Series (2000), 129

Detailed reference viewed: 7 (1 ULg)
Peer Reviewed
See detailBegian guidelines concerning drug induced alteration of coagulation and central neuraxial anesthesia
Brichant, Jean-François ULg; De Kock, Marc; De Mey, J. C. et al

in Acta Anaesthesiologica Belgica (2000), 51

Detailed reference viewed: 17 (0 ULg)
See detailLes brulis, un outil de gestion de la faune en region Afrique inter-tropicale.
Cornelis, D.; Lungren, C.; Ouedraogo, Mohamar moussa ULg et al

in Parcs & Réserves (2000), 55(3-4),

Detailed reference viewed: 34 (13 ULg)
Peer Reviewed
See detailL'etude clinique du mois. L'apres DCCT, l'etude EDIC.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(3), 187-9

The "Diabetes Control and Complications Trial" (DCCT) demonstrated that intensive insulin therapy, by reducing HbA1c levels by about 2%, delays the onset and slows the progression of microangiopathic ... [more ▼]

The "Diabetes Control and Complications Trial" (DCCT) demonstrated that intensive insulin therapy, by reducing HbA1c levels by about 2%, delays the onset and slows the progression of microangiopathic complications (by at least 50%) in patients with type 1 diabetes. The "Epidemiology of Diabetes Interventions and Complications" (EDIC) study recently showed that the reduction in the risk of progressive retinopathy and nephropathy resulting from intensive therapy during the DCCT not only persists, but is amplified for at least 4 years (reduction by about 80% when compared to diabetic patients previously treated with conventional therapy during the DCCT). [less ▲]

Detailed reference viewed: 50 (0 ULg)
Full Text
Peer Reviewed
See detailRole Of Surface Chemical Signals In Egg Cannibalism And Intraguild Predation In Ladybirds (Coleoptera : Coccinellidae)
Hemptinne, Jl.; Lognay, Georges ULg; Gauthier, Carole ULg et al

in Chemoecology (2000), 10(3), 123-128

The eggs of some ladybirds are known to be toxic to intraguild ladybird predators. However, this defence is of little value if the eggs are killed before their toxicity becomes apparent. The results ... [more ▼]

The eggs of some ladybirds are known to be toxic to intraguild ladybird predators. However, this defence is of little value if the eggs are killed before their toxicity becomes apparent. The results presented in this paper indicate that chemicals on the surface of the eggs of two species of ladybirds signal the relative risk of cannibalism and intraguild predation. In Adalia bipunctata and Coccinella septempunctata, 87% of the chemicals are alkanes. Each species of ladybird is less reluctant to eat their own eggs than those of the other species. This asymmetry is to be expected because there is a greater risk to ladybirds from intraguild predation than cannibalism. Similar alkanes to those on the surface of the eggs of A. bipunctata are present in tracks left by larvae and on the elytra of the adults of this species. Those in the larval tracks deter females from ovipositing in patches of prey already being attacked by their larvae and those on the elytra are used in mate recognition. That different context dependent messages could be signalled by similar chemicals is an example of semiochemical parsimony. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Peer Reviewed
See detailDe la medecine factuelle aux recommandations therapeutiques. Epilogue.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (2000), 55(5), 476-7

Detailed reference viewed: 23 (3 ULg)
Full Text
Peer Reviewed
See detailDéveloppement durable et organisation urbaine : le mot dʼordre de la ville compacte
Halleux, Jean-Marie ULg

in Cahiers de l'Urbanisme (Les) (2000), (30), 18-23

Detailed reference viewed: 100 (9 ULg)
Peer Reviewed
See detailFrom obesity to diabetes: why, when and who?
Scheen, André ULg

in Acta Clinica Belgica (2000), 55(1), 9-15

Obesity is considered as the most important risk factor for type 2 diabetes. We will briefly discuss why does obesity predispose to diabetes, when does diabetes occur in obese subjects and who among obese ... [more ▼]

Obesity is considered as the most important risk factor for type 2 diabetes. We will briefly discuss why does obesity predispose to diabetes, when does diabetes occur in obese subjects and who among obese individuals is particularly prone to develop diabetes. Obesity, especially intraabdominal adiposity, is associated with increased FFA plasma concentrations which exert a major negative effect on insulin sensitivity at both muscular and hepatic sites. Various metabolic, haemodynamic and hormonal theories have been proposed to explain insulin resistance in obese subjects. A specific role of TNF-alpha has been recently suggested. However, besides insulin resistance, defective insulin secretion is a prerequisie for the development of overt type 2 diabetes. Both lipotoxicity and glucotoxicity may initiate and perpetuate a vicious circle responsible for the metabolic deterioration. Diabetes occurs as a late phenomenon in obesity and is preceded by years of impaired glucose tolerance. The progression to diabetes is heralded by an inability of the B cell to maintain its previously high rate of insulin secretion in response to glucose in face of insulin resistance. This propensity to develop type 2 diabetes may be genetically determined and/or triggered by environmental factors. The evolution from obesity to diabetes represents a continuum that progresses through different phases in which defects in both insulin action and insulin secretion play a critical interaction and must be looked at in concert. [less ▲]

Detailed reference viewed: 27 (2 ULg)
Full Text
Peer Reviewed
See detailLa contamination de l'eau et des aliments par les virus pathogènes pour l'homme
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (2000), 144

Detailed reference viewed: 47 (1 ULg)
Full Text
Peer Reviewed
See detailAbout the Vacuum UV Photoabsorption Spectrum of Methyl Fluoride (CH3F): the fine structure and its vibrational analysis.
Locht, Robert ULg; Leyh, Bernard ULg; Hoxha, A. et al

in Chemical Physics (2000), 257

The vacuum UV photoabsorption spectrum of CH3F has been recorded between 7 and 24 eV and has been analyzed in detail. Broad and structureless peaks are observed over the entire photon energy range. They ... [more ▼]

The vacuum UV photoabsorption spectrum of CH3F has been recorded between 7 and 24 eV and has been analyzed in detail. Broad and structureless peaks are observed over the entire photon energy range. They are all assigned to transitions to Rydberg states, members of series converging to the 2e-1, 5a-1 and 1e-1 ionization limits. These features are underlying very long series of narrow and weak structures in the range of 10-13.2 eV. Through a continuum subtraction procedure, about 70 lines could clearly be identified. These have been assigned to long vibrational progressions belonging to Rydberg states corresponding to the 2e->3p and 2e->6s/5d configurations. These states are split by a Jahn-Teller distortion. Ab initio calculations lead to a Jahn-Teller stabilization energy of about 0.84 eV. The main features observed in the two bands are assigned to one single long vibrational progression of hcomega=0.160 eV (1290cm-1) related to the C-F Jahn-Teller inactive stretching vibration. The remaining structure is assigned to the low excitation of the Jahn-Teller active vibrational modes, i.e. the bending modes nu5 and nu6 characterized by hcomega5=0.120 eV (970 cm-1) and hcomega6=0.082 eV (660 cm-1). Leaning on the present results and assignments previously reported photoelectron spectroscopic data on CH3F+ [L. Karlsson, R. Jadrny, L. Mattsson, F.T. Chau, K. Siegbahn Phys.Scripta 16 (1977) 225] have been reconsidered and reinterpreted. [less ▲]

Detailed reference viewed: 64 (3 ULg)
Peer Reviewed
See detailMolecular diversity of Microcystis strains (Cyanophyceae, Chroococcales) based on 16S rDNA sequences
LEPERE, Claire ULg; Wilmotte, Annick ULg; Meyer, Barbara

in Systematics and Geography of Plants (2000), 70

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These ... [more ▼]

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These sequences appear very similar to each other and to those of 71 Microcystis strains from four continents available in the databases. This great genotypic homogeneity, as measured by 16S rDNA sequence similarity (334 characters), is contrasting with the conspicuous morphological differences observed for the studied strains. [less ▲]

Detailed reference viewed: 103 (5 ULg)
Peer Reviewed
See detailThe Inferior Non Recurrent Laryngeal Nerve: A Major Surgical Risk During Thyroidectomy
Defechereux, Thierry ULg; Albert, V.; Alexandre, j et al

in Acta Chirurgica Belgica (2000), 100(2, Mar-Apr), 62-7

It is now widely established that systematic intraoperative location and diligent dissection of the recurrent inferior laryngeal nerve during thyroidectomy are the keystones to assure its anatomic and ... [more ▼]

It is now widely established that systematic intraoperative location and diligent dissection of the recurrent inferior laryngeal nerve during thyroidectomy are the keystones to assure its anatomic and functional preservation. The possibility of abnormal routes, like a non-recurrent cervical course of the inferior laryngeal nerve is an additional major argument for its systematic identification to avoid surgical damage. In 2517 cervicotomies performed between 1992 and 1997 for at least right thyroid lobe excision or parathyroid glands exploration, 20 cases of non recurrent laryngeal nerve were identified (0.79%). The embryological nature of such a nervous anatomical variation results originally from a vascular disorder, named arteria lusoria in which the fourth right aortic arch is abnormally absorbed, being therefore unable to drag the right recurrent laryngeal nerve down when the heart descends and the neck elongates during embryonic development. The surgeon must be aware of the possibility of a non recurrent laryngeal nerve, which arises directly from the cervical vagus and therefore represents a severe potential pitfall during thyroidectomy. Given the absence of reliable clinical symptoms and signs or investigations indicating preoperatively the possibility of a non recurrent nerve, guidelines are given to prevent intraoperatively this major surgical risk. [less ▲]

Detailed reference viewed: 45 (0 ULg)
Full Text
Peer Reviewed
See detailLes stratégies de reproduction chez les poissons labridés méditerranéens
Ylieff, Marc ULg

in Cahiers d'Ethologie (2000), 20(1), 113-138

In contrast to tropical environments, Mediterranean fish assemblages have been exposed to greater seasonal fluctuations of climatic factors (water temperature, photoperiod), which have impacted more or ... [more ▼]

In contrast to tropical environments, Mediterranean fish assemblages have been exposed to greater seasonal fluctuations of climatic factors (water temperature, photoperiod), which have impacted more or less significantly on the biology of fish. The labrid fishes (wrasses) are good examples of how climatic changes influence behavioural strategies. The European wrasses differ mainly from the tropical ones by their particular reproductive behavioural patterns. In these wrasses, the variety of the reproductive strategies (hermaphroditism or gonochorism, spawning seasonality in open water or on substrates, degrees of parental care, etc.) make it possible to study the evolution of these strategies. If in tropics, most of wrasses exhibit planktonic spawning, the Mediterranean ones adapted their behaviour, developing modes of reproduction unusual in tropics: short periods of reproduction, spawning eggs on substrates or in elaborated nest, parental cares. This evolution is dictated, in particular, by the pressure of climatic factors, such as water temperature on the presence or the absence of parental care. Of the 21 Mediterranean species, almost all the species studied lay their eggs on substrates or in a nest built by the large territorial male. Only Coris julis, Thalassoma pavo and Xyrichthys novacula (protogynous hermaphroditism fishes) spawn in open water (planktonic spawning) as tropical species do. Moreover, the majority of Symphodus males have complex social structures where nesting territorial, satellite and sneaker males can be recognised. These sneakers adopt reproductive behavioural patterns known as alternative reproductive behaviour. They can either steal the spawn (streaking), or steal the female (sneaking). Finally, the majority of these Symphodus give parental care throughout each nesting cycle (2 to 5 nests are elaborated during the reproductive season in spring), which always comprises three phases: nest building phase (construction with alive algae of a substrate for spawning or a true nest in form of cup), sexual activity phase (the very moment the females come to spawn in the nest) and fanning phase (oxygenation of eggs, by the beat of the pectoral fins, until hatching). The diversity of the biological and behavioural adaptations developed by the numerous tropical and temperate species of labrid fishes allow us to consider the family as an ideal group to investigate various problems in behavioural ecology. [less ▲]

Detailed reference viewed: 66 (8 ULg)
Peer Reviewed
See detailAntiobesity pharmacotherapy in the management of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes/Metabolism Research & Reviews (2000), 16(2), 114-24

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction ... [more ▼]

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction should be considered as a key objective. In this respect, several antiobesity drugs have demonstrated potential. However, while fenfluramine and dexfenfluramine have been shown to promote weight loss and to directly improve insulin sensitivity, being two mechanisms contributing to better blood glucose control in obese Type 2 diabetic patients, they were recently withdrawn due to safety problems. Sibutramine, a new selective norepinephrine and serotonin reuptake inhibitor, promotes weight loss by decreasing food intake, an effect which leads to a mild improvement (significant in patients losing > or =5% of initial body weight) of blood glucose control in obese diabetic patients. Similarly, orlistat, a selective gastrointestinal lipase inhibitor which increases faecal fat losses, enhances diet-induced weight reduction and improves both blood glucose control and vascular risk profile, especially dyslipidaemia, in obese Type 2 diabetic patients. Further studies are required to better identify good responders to pharmacotherapy and specify the role of antiobesity agents in the overall long-term management of obese subjects with Type 2 diabetes. Other novel pharmacological approaches deserve further consideration, for instance beta-3 agonists aiming to increase energy expenditure, drugs interfering with tumor necrosis factor-alpha (TNF-alpha) or free fatty acid release by the adipose tissue or agents that slow gastric emptying. However, until now, results regarding efficacy and/or safety have been disappointing or preliminary in humans. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

Detailed reference viewed: 9 (2 ULg)
Peer Reviewed
See detailCore-polarization effects in Cu II
Biémont, Emile ULg; Pinnington, E. H.; Quinet, Pascal ULg et al

in Physica Scripta (2000), 61

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailmicromachined inertial sensors: the state-of-the-art and a look into the future
Kraft, Michaël ULg

in Measurement and Control (2000), 33(6), 164--168

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailEmissions de vapeur d’eau et bilan azoté lors de l’élevage de porcelets sevrés sur litière accumulée de sciure
Nicks, Baudouin ULg; Laitat, Martine ULg; Vandenheede, Marc ULg et al

in Annales de Zootechnie (2000), 49

Five batches of a total of 180 weaned pigs were reared successively in an experimental room on 30 cm deep litter without cleaning between the batches. The litter was a mixture of sawdust from coniferous ... [more ▼]

Five batches of a total of 180 weaned pigs were reared successively in an experimental room on 30 cm deep litter without cleaning between the batches. The litter was a mixture of sawdust from coniferous and beech trees. Water was added to the Litter every 10 days to lower the dust concentration in the room. The total amounts of sawdust and water used were respectively 21.3 kg per pig and 10.21 per pig. The mean temperature of the litter at 20 cm depth recorded during each of the 5 periods varied from 32.5 degrees C to 41.8 degrees C. The average liveweight of the pigs at the beginning and at the end of the post-weaning period was respectively 7.9 +/- 1.2 kg and 24.5 +/- 4.2 kg. The average daily gain was 392 +/- 87 g. The temperature and the relative humidity of the air inside and outside the experimental room and the ventilation rate were continuously recorded in order to calculate the water vapour emission for each batch. The amount of water vapour produced was significantly correlated to the water consumption of the pigs and reached an average of 1 732 g per pig per day. This amount is 36% greater than the reference used for pigs on slatted floors. This value may be used as a reference to calculate the minimum ventilation rate for piggeries with pigs on sawdust deep litters. The amount of compost produced was 19.9 kg per pig with a dry matter content of 44.7%. The amount of nitrogen in the compost was 231 g per pig which is about 50% lower than the reference used for the slurry. The volatile nitrogen emissions are thus much higher from composts than from slurries [less ▲]

Detailed reference viewed: 27 (3 ULg)