References of "Article"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailPhotometric monitoring (1987 to 1994) of the gravitational lens candidate UM 425.
Courbin, F.; Magain, Pierre ULg; Remy, M. et al

in Astronomy and Astrophysics (1995), 303

We present the results of a 7 year long photometric monitoring of two components (A and B) of UM 425, thought to be images, separated by 6.5", of the same z=1.47 quasar. These components have been imaged ... [more ▼]

We present the results of a 7 year long photometric monitoring of two components (A and B) of UM 425, thought to be images, separated by 6.5", of the same z=1.47 quasar. These components have been imaged through an R filter in order to obtain their light curves. The photometry was obtained by simultaneously fitting a stellar two-dimensional profile on each component. The brightest image (component A, m_R_=15.7) shows a slow and smooth increase in brightness of 0.2 magnitude in seven years, while the faintest one (component B, m_R_=20.1) displays an outburst of 0.4 magnitude which lasts approximately two years. The variation of component B may be interpreted in two ways, assuming UM 425 is gravitationally lensed. If it is due to an intrinsic variation of the quasar, we derive a lower limit of 3 years on the time delay from the fact that it is not observed in component A. On the other hand, if it is a microlensing "High Amplification Event", we estimate the size of the source to be ~10^-3^pc, in agreement with standard models of AGNs. These observations are consistent with the gravitational lens interpretation of the object. Furthermore, all the CCD frames obtained under the best seeing conditions have been co-added, in an attempt to detect the deflector. The final R image reveals a rich field of faint galaxies in the magnitude range m_R_~22-24. No obvious deflector, nor any system of arcs or arclets is detected, down to a limiting magnitude of m_R_~24. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detail"Music alone survives”? The collapse of faith in sonnets by Geoffrey Hill and G.M. Hopkins’
Pagnoulle, Christine ULg

in Cahiers Victoriens & Edouardiens (1995), 42

The present article explores the various ways in which Geoffrey Hill uses the regularity of the sonnet form to express the impossibility of faith, and how this collapse was announced in some of Hopkins's ... [more ▼]

The present article explores the various ways in which Geoffrey Hill uses the regularity of the sonnet form to express the impossibility of faith, and how this collapse was announced in some of Hopkins's most famous celebratory sonnet 'The Windhover.' [less ▲]

Detailed reference viewed: 46 (12 ULg)
Full Text
Peer Reviewed
See detailEffect of naloxone and metoclopropamide on LH secretion in a hyperprolactinemic, hypogonadotropic, postmenopausal woman, fertility and sterility.
Verhelst, J.; Beckers, Albert ULg; Abs, R.

in Fertility and Sterility (1995), 64(5), 969-971

OBJECTIVE: To determine the role of opioidergic and dopaminergic activity in the suppression of GnRH0LH in a hyperprolactinemic state. DESIGN: Case report. SETTING: University hospital. PATIENT: A 68-year ... [more ▼]

OBJECTIVE: To determine the role of opioidergic and dopaminergic activity in the suppression of GnRH0LH in a hyperprolactinemic state. DESIGN: Case report. SETTING: University hospital. PATIENT: A 68-year-old woman with a macroprolactinoma. INTERVENTIONS: Serial 10-hour IV infusions of naloxone and metoclopramide. MAIN OUTCOME MEASURE: Serum LH concentration. RESULTS: Naloxone induced a small but significant rise of serum LH levels, which displayed a pulsatile pattern. By contrast, metoclopramide elicited no significant response in LH secretion. CONCLUSION: Opioidergic but not dopaminergic neurotransmission plays a direct role in the suppression of LH secondary to hyperprolactinemia. [less ▲]

Detailed reference viewed: 34 (0 ULg)
Full Text
Peer Reviewed
See detailFactors influencing the immediate and late outcome of cushing-disease treated by transsphenoidal surgery : A retrospective study by the european cushings-disease survey group
Bochicchio, D.; Losa, M.; Buchfelder, M. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(11), 3114-3120

Hypercortisolism attributable to hypersecretion of ACTH by a pituitary adenoma is an uncommon and progressively lethal disease. Because of its rarity, it has been difficult to collect a large series of ... [more ▼]

Hypercortisolism attributable to hypersecretion of ACTH by a pituitary adenoma is an uncommon and progressively lethal disease. Because of its rarity, it has been difficult to collect a large series of patients in order to identify the prognostic factors influencing the outcome after transsphenoidal surgery. We conducted a multicenter, retrospective analysis of the early and late results of surgical treatment of Cushing's disease. Files of patients with Cushing's disease who underwent transsphenoidal surgery between 1975 and 1990 were collected from 25 institutions throughout Europe. Data from 668 of 716 patients were suitable for statistical analyses. Surgical mortality was 1.9%, and major morbidity occurred in 97 patients (14.5%). Clinical and biochemical remission of Cushing's disease after surgery occurred in 510 cases (76.3%). Identification of the tumor by neuroradiological imaging or at operation with histopathological corroboration was associated with remission of hypercortisolism. Recurrence of the disease occurred in 65 (12.7%) of 510 patients in remission after surgery at a mean time of 39.3 months (range 6-104 months). The distribution of the recurrences did not show any apparent plateau or cluster throughout the follow-up period. Low postoperative steroid levels, absence of cortisol response to CRH, and the need for long-term glucocorticoid substitution therapy were all associated with a high probability of long-term remission. Our study demonstrates that transsphenoidal surgery is a safe and effective treatment for patients with Cushing's disease. However, after successful surgery there is a steady increase in the percentage of recurrences, which continues with time. Patients who after operation had hypoadrenocorticism and needed long-term glucocorticoid substitution therapy had the lowest risk of relapse. [less ▲]

Detailed reference viewed: 227 (1 ULg)
Full Text
Peer Reviewed
See detailPreparation of a Macroporous Biodegradable Polylactide Implant for Neuronal Transplantation
Schugens, C.; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Biomedical Materials Research (1995), 29(11), 1349-62

This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an ... [more ▼]

This article reports the production of a surgical implant meeting several specific requirements such as biocompatibility, biodegradability, macroporosity, and flexibility. Porosity was controlled by an original method consisting of the aggregation of calibrated poly-D,L-lactide microparticles. The size of the interstices between the aggregated microspheres was in a direct relationship to the microsphere diameter. A first approach was based on coating the microspheres with poly(vinyl alcohol) followed by chemically crosslinking the coating layers that were in mutual contact. This method was disregarded because of the acute cytotoxicity of glutaraldehyde used as the crosslinking agent, the absence of macroporosity, and the complete lack of flexibility. A physical technique of aggregation was then tested, which relied on the plasticization of poly-D,L-lactide microspheres with triethylcitrate to the point where microspheres strongly adhered to each other when they were in contact. This method has proved to be straightforward and definitely superior to the chemical approach, particularly with respect to cytotoxicity, control of macroporosity, and flexibility. A polymer support was thus successfully which was biodegradable, macroporous( interconnected pores of 10-100 microns in diameter), and flexible. This potential medical device is presently being used for neuronal transplantation in the central nervous system. [less ▲]

Detailed reference viewed: 27 (5 ULg)
Peer Reviewed
See detailLe cas clinique du mois. Dépression majeure chez un patient diabétique
Pitchot, William ULg; Ansseau, Marc ULg

in Revue Médicale de Liège (1995), 50(11), 451-2

Detailed reference viewed: 16 (3 ULg)
Full Text
Peer Reviewed
See detailEfficacy and Safety of Drugs for Paget's Disease of Bone
Reginster, Jean-Yves ULg; Lecart, M. P.

in BONE (1995), 17(5 Suppl), 485-488

Paget's disease of bone is characterized by an anarchic bone turnover starting with excessive resorption caused by structural and functional abnormalities involving osteoclasts. Calcitonin and ... [more ▼]

Paget's disease of bone is characterized by an anarchic bone turnover starting with excessive resorption caused by structural and functional abnormalities involving osteoclasts. Calcitonin and bisphosphonates are now considered as the main therapeutic approaches for this disease. Daily parenteral administration of calcitonin to patients with Paget's disease of bone results in a significant fall in serum alkaline phosphatase and urinary hydroxyproline levels. This treatment has also been reported to be effective in relieving clinical symptoms of the disease, mainly bone pain. The drawbacks of injectable calcitonin have stimulated interest in alternative routes of delivery. Substantial evidence of calcitonin bioavailability and bioefficacy equivalent to those of parenteral administration is currently available for only two alternative routes: nasal spray and rectal suppository. Since many results have been published showing a dramatic effect of several bisphosphonates in Paget's disease of bone, nasal and rectal calcitonin are no longer considered as the treatments of choice in this condition. A major advantage of the use of bisphosphonates over calcitonin in Paget's disease is that biochemical and histologic suppression of disease activity may persist for many years after the cessation of treatment. Oral etidronate and intravenous pamidronate have been extensively used and have provided satisfactory benefits to the patient. Since the risk/benefit ratio of alendronate does not appear to be completely positive, it is likely that the future of treatment of Paget's disease of bone will be based on the oral formulation of the new bisphosphonates, including tiludronate, risedronate or dimethyl-pamidronate. [less ▲]

Detailed reference viewed: 7 (2 ULg)
Full Text
Peer Reviewed
See detailIs Sepsis a Mediator-Inhibitor Mismatch?
Lamy, Maurice ULg; Deby, Ginette ULg

in Intensive Care Medicine (1995), 21(Suppl 2), 250-7

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailThe prevalence of colonic polyps in acromegaly : a prospective colonoscopic and pathological study in 103 patients.
Delhougne, B.; Deneux, C.; Abs, R. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(11), 3223-3226

Patients with acromegaly are reported to be at risk of developing adenomatous colonic polyps, which are considered to be preneoplastic lesions. This assumption is, however, usually drawn from results ... [more ▼]

Patients with acromegaly are reported to be at risk of developing adenomatous colonic polyps, which are considered to be preneoplastic lesions. This assumption is, however, usually drawn from results obtained in rather small series of patients or without a control group. We, therefore, undertook a prospective colonoscopic and pathological study comprising 103 acromegalic patients and 138 nonacromegalic control subjects referred for irritable bowel syndrome. The prevalence of adenomatous colonic polyps was significantly increased in acromegalic patients compared to that in control subjects (22.3% vs. 8.0%; P = 0.0024). The significance was similarly present in male acromegalic patients (28.6% vs. 5.5% in male control subjects; P = 0.0026), but was absent in female acromegalic patients. The prevalence of colonic polyps was also significantly increased in the group of acromegalic patients under 55 yr of age (20.0% vs. 3.0% in the control group of the same age; P = 0.0026). Other characteristics of adenomatous colonic polyps in acromegaly were the multiplicity and the presence proximal to the splenic flexure. No difference in the duration of acromegaly was found between patients with or without adenomatous polyps. The prevalence of hyperplastic colonic polyps was also significantly increased to 24.3% in acromegalic patients vs 4.4% in control subjects (P < 0.001). In conclusion, in view of the increased incidence of adenomatous colonic polyps, colonoscopy should be part of the follow-up examination in acromegaly. [less ▲]

Detailed reference viewed: 63 (6 ULg)
Peer Reviewed
See detailEvaluation and comparison of the behaviour at sea and forces in cables of two types of offshore tension leg platforms
Marchal, Jean ULg; Lejeune, A.

in International Symposium on CABLE DYNAMICS (1995)

Detailed reference viewed: 12 (5 ULg)
Full Text
Peer Reviewed
See detailRetinoic Acid Induces Three Newly Cloned Hoxa1 Transcripts in Mcf7 Breast Cancer Cells
Chariot, Alain ULg; Moreau, Louis; Senterre, Geoffrey et al

in Biochemical and Biophysical Research Communications (1995), 215(2), 713-20

Coordinated expression of genes involved in development, differentiation and malignant transformation is regulated by transcription factors including homeodomain-containing proteins. However, most of ... [more ▼]

Coordinated expression of genes involved in development, differentiation and malignant transformation is regulated by transcription factors including homeodomain-containing proteins. However, most of their cDNA sequences are still unknown. We report here the molecular characterization of three newly cloned HOXA1 transcripts from human breast cancer cells. In addition, we provide evidence that these alternatively spliced transcripts encode one homeodomain-containing protein and two products lacking the conserved DNA-binding domain. Moreover, we demonstrate that all three HOXA1 transcripts are induced by retinoic acid in MCF7 cells. Taken together, our results suggest that HOXA1 gene may be a key element in the establishment of the breast cancer cell phenotype. [less ▲]

Detailed reference viewed: 17 (6 ULg)
Full Text
Peer Reviewed
See detailAnionic polymerization of pivalolactone initiated by alkali metal alkoxides
Jedlinski, Zbigniew; Kurcok, Piotr; Kowalczuk, Marek et al

in Macromolecules (1995), 28(21), 7276-7280

Polymerization of pivalolactone (alpha,alpha-dimethyl-beta-propiolactone) initiated with alkali metal alkoxides has been studied. It has been revealed that after addition of an alkoxide anion, from the ... [more ▼]

Polymerization of pivalolactone (alpha,alpha-dimethyl-beta-propiolactone) initiated with alkali metal alkoxides has been studied. It has been revealed that after addition of an alkoxide anion, from the initiator, onto the carbonyl carbon atom of the monomer the selective cleavage of the acyl-oxygen bond of the monomer leads to the formation of alkoxide propagating species. Thus, it has been demonstrated that, in contrast to alpha-unsubstituted beta-lactones and higher lactones, the anionic polymerization of pivalolactone proceeds through either alkoxide or carboxylate propagation centers, depending on the nature of initiator used, i.e. an alkoxide or a carboxylate, respectively. In the former case, however, cyclic oligomers are also formed which are unusual in the anionic polymerization of other beta-lactones. This indicates that, whatever the lactone ring size (four-, six-, or seven-membered lactones), intramolecular transesterification reactions can take place if alcoholate ions are propagating species. [less ▲]

Detailed reference viewed: 28 (1 ULg)
Full Text
Peer Reviewed
See detailLong-term photometry of variables at ESO. IV. The fourth data catalogue (1992-1994).
Sterken, C.; Manfroid, Jean ULg; Beele, D. et al

in Astronomy and Astrophysics. Supplement Series (1995), 113

In this paper we present the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992-August 23, 1994 in the framework of the Long-Term Photometry of ... [more ▼]

In this paper we present the fourth catalogue of photometric data in the Stroemgren system obtained during the period June 18, 1992-August 23, 1994 in the framework of the Long-Term Photometry of Variables (LTPV) program at the European Southern Observatory. The catalogue is available in computer readable form at the Centre de Donnees de Strasbourg via anonymous ftp 130.79.128.5. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailLack of universality in 2-dimensional multicomponent spreading phenomena
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(4), 3447-3454

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states ... [more ▼]

Magnetic entities are introduced in a two-dimensional Eden model as additional degrees of freedom in order to model multidomain spreading phenomena. The elements of the growth are "spins" taking q states and are coupled or not via an energy J, as in the Potts model, thus leading to a competition between species. The internal cluster spreading is found to result from a competition between growing domains. Complex mechanisms such as trapping, jamming and coalescence occur between the growing domains. A large variety of critical and nanuniversal regimes, from subcritical to self-organized critical behaviors, are obtained depending on nonuniversal parameters such as the lattice structure, the number of internal degrees of freedom q, and the coupling J. For the square lattice, the fractal dimension is 1.50 and the mass distribution exponent tau is 1.63. For the triangular lattice, the fractal dimension varies from 1.70 to 1.83 depending on the coupling value and the mass distribution exponent tau also varies from 1.67 to 1.98 depending on the coupling value. The correspondence and differences with respect to the percolation phenomenon are outlined. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailEffect of Plasma Anticonvulsant Level on Pipecuronium-Induced Neuromuscular Blockade: Preliminary Results
Hans, Pol ULg; Ledoux, Didier ULg; Bonhomme, Vincent ULg et al

in Journal of Neurosurgical Anesthesiology (1995), 7(4), 254-8

Patients receiving anticonvulsants are resistant to nondepolarizing muscle relaxants (NDMR). This study examines the effect of plasma anticonvulsant levels on pipecuronium-induced neuromuscular blockade ... [more ▼]

Patients receiving anticonvulsants are resistant to nondepolarizing muscle relaxants (NDMR). This study examines the effect of plasma anticonvulsant levels on pipecuronium-induced neuromuscular blockade. Twenty adult patients scheduled for neurosurgery were assigned to one of two groups. Group 0 (G0) consisted of 10 patients not on anticonvulsant therapy; group 1 (G1) included 10 patients treated either with phenytoin or carbamazepine. G1 patients were further divided into G1u (n = 4) and G1w (n = 6) subgroups, according to the plasma anticonvulsant level measured the day before surgery--under (G1u) or within (G1w) the therapeutic range. Neuromuscular transmission was monitored with a Biometer International A/S Accelograph. Anesthesia was induced and maintained using propofol and sufentanil. After calibration of the accelograph, a bolus of pipecuronium 0.08 mg/kg was given IV. The time from pipecuronium injection to the peak reduction of T1 was taken as the onset time. The time in min from pipecuronium injection to recovery of T1% (first accelograph response/baseline response) x 100 and TR% (fourth accelograph response/first accelograph response) x 100 were recorded at 25, 50, and 75% of baseline. The recovery index (RI) was taken as the time from 25 to 75% of baseline. The recovery index (RI) was taken as the time from 25 to 75% recovery of the baseline response. The onset time was not different in G0 (203 +/- 60.4 s), G1 (230.5 +/- 79.3 s), and G1u (181.8 +/- 60.4 s) but prolonged in G1w (279.2 +/- 67.7 s).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

Detailed reference viewed: 23 (3 ULg)
Peer Reviewed
See detailLes cereales dans l'alimentation des bovins: valeur nutritionnelle et recommandations pour une utilisation sans risque.
Thewis, André ULg; Decruyenaere, Virginie

in Elevages Belges (1995), 49(10), 9-12

Detailed reference viewed: 141 (1 ULg)
Peer Reviewed
See detailLumière and his View : the Cameraman's Eye in Early Cinema
Belloi, Livio ULg

in Historical Journal of Film, Radio & Television (1995), 15

Analyse des scènes de rue produites par la firme Lumière comme résultats d'une interaction entre l'opérateur et les sujets filmés.

Detailed reference viewed: 69 (8 ULg)
Full Text
Peer Reviewed
See detailThe Impact of Renal Revascularisation on Renal Dysfunction
Van Damme, Hendrik ULg; Jeusette, F.; Pans, Alain ULg et al

in European Journal of Vascular and Endovascular Surgery : The Official Journal of the European Society for Vascular Surgery (1995), 10(3), 330-7

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990 ... [more ▼]

AIM: To determine the value of kidney revascularisation in patients with impaired renal function and correctable renal artery stenosis, the authors reviewed their surgical experience from 1978 to 1990. PATIENTS AND METHODS: The study population included 23 patients with ischaemic nephropathy whose preoperative baseline creatinine level exceeded 20 mg/l (range 21-65 mg/l). This represents 20% of all patients operated on for renal artery disease during the same time interval. Preoperative risk profile, operative mortality, impact on hypertension and on renal function, and late survival were analysed. Renal function response to kidney revascularisation was defined as favourable (20% or more reduction of serum creatinine), moderate (stabilised serum creatinine values) or bad (further deterioration of renal function). All patients had atherosclerotic renal artery disease, involving a solitary kidney in five, both kidneys in 15 and one of the two kidneys in three patients. Hypertension was present in 74%. Revascularisation was unilateral in 10, bilateral in nine and associated with controlateral nephrectomy in four patients. RESULTS: Four patients died postoperatively (three myocardial infarctions, one stroke). Four patients needed postoperative short-term dialysis. After operation, renal function improved in 13, stabilised in six and deteriorated in four patients (of whom two died). Follow-up among the survivors averaged 46 months. The mean serum creatinine value at last follow-up visit was 26.2 mg/l, a decrease of 7.7 mg/l compared to preoperative values (p < 0.05). Overall, 69% of azotemic patients submitted to renal revascularisation manifested a favourable response (45% improved and 24% stabilised). Three patients required long-term dialysis. The 5-year survival rate was 48%. CONCLUSION: These data suggest that kidney revascularisation in patients with ischaemic nephropathy can restore or stabilise renal function, preventing evolution and end-stage renal disease and dialysis dependency. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailAntioxidant Defense and Free Radical Production in a Rabbit Model of Kidney Ischemia-Reperfusion
Franssen, Colette ULg; Defraigne, Jean-Olivier ULg; Detry, Olivier ULg et al

in Transplantation Proceedings (1995), 27(5), 2880-3

Detailed reference viewed: 41 (0 ULg)
Peer Reviewed
See detailExercise in the Management of Non-Insulin-Dependent (Type 2) Diabetes Mellitus
Gautier, J. F.; Scheen, André ULg; Lefebvre, P. J.

in International Journal of Obesity & Related Metabolic Disorders (1995), 19(Suppl 4), 58-61

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailAdsorption behavior of polymers with ionic end groups : mono- and difunctional polystyrenes in toluene
Pankewitsch, T.; Vanhoorne, Pierre ULg; Jérôme, Robert ULg et al

in Macromolecules (1995), 28(20), 6986-6992

The adsorption behavior of mono- and difunctional telechelic polymers, omega- and alpha,omega-sulfonato polystyrenes, from dilute toluene solution on the surface of a silicon wafer is investigated by ... [more ▼]

The adsorption behavior of mono- and difunctional telechelic polymers, omega- and alpha,omega-sulfonato polystyrenes, from dilute toluene solution on the surface of a silicon wafer is investigated by ellipsometry. Polystyrene without ionic end groups does not adsorb, and the attachment of molecules to the silicon dioxide surface proceeds via the functional ionic ends. Already a single ionic group promotes adsorption, and adsorption kinetics at small times is found to be diffusion limited. The approach of an equilibrium adsorbed amount at later times is controlled by the hindered diffusion of chains through the already existing layer. With monofunctional chains a thin stable monolayer at the surface is formed. With difunctional chains there is strong indication for coupling of ionic ends and the formation of additional layers. It is caused by the interaction of dangling ends, when only one end of the chains is adsorbed at the surface. The molecular weight dependence of the grafting density is consistent with scaling predictions, and differences in the adsorbed amount of telechelics with different counterions are explained on the basis of different valencies. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailSmall-angle neutron scattering studies of low-polarity telechelic ionomer solutions. 1. Total scattering
Karayianni, Eleni; Jérôme, Robert ULg; Cooper, Stuart L

in Macromolecules (1995), 28(19), 6494-6507

The overall structure and thermodynamic interactions that take place,in low-polarity ionomer solutions have been investigated via the technique of small-angle neutron scattering for two Na-neutralized ... [more ▼]

The overall structure and thermodynamic interactions that take place,in low-polarity ionomer solutions have been investigated via the technique of small-angle neutron scattering for two Na-neutralized carboxy-telechelic polystyrene model ionomer systems that differ in the length of the polymer backbone. The strong interchain association that is evidenced in the viscometric measurements of the ionomers compared to the ester forms is apparent in the scattering profiles of the ionomers that show a characteristic upturn that extends in the low-q regime and increases with increasing polymer concentration. The apparent molecular weight and size of the aggregated particles show a significant increase over a small concentration range, while the ionic content seems to not affect the degree of association in the concentration regime studied. The supramolecular structure of the ionomer solutions is revealed by fitting the scattering data to a scaling law in the intermediate qR(g) regime that supports a percolation type of behavior for the ionomer clusters for both systems studied. The fractal dimension of the aggregates is 1.76 for both ionomer systems which provides evidence for a rather extended configuration and high polydispersity of the clusters in solution. The molecular weight of the associating particles is observed to rapidly approach infinity with increasing polymer concentration, indicating the approach to a gel transition. The scattering data of the ionomer solutions were fitted to the de Gennes model based on the random-phase approximation theory. The Flory-Huggins interaction parameter of the ionomer solutions determined using this model shows a strong concentration dependence with a quite unexpected increase with decreasing polymer concentration. The thermodynamic interactions in the ionomer solutions were changed dramatically by the association as revealed by a significant decrease of the second virial coefficient. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
See detailEspace et mémoire
Frankignoulle, Pierre ULg

in Le Magazine Liège Université (1995)

Detailed reference viewed: 18 (3 ULg)
Full Text
Peer Reviewed
See detailSystemic Immune Response after Rectocolonic Administration of Ovalbumin in Mice
Louis, Edouard ULg; Franchimont, D.; Lamproye, Anne ULg et al

in International Archives of Allergy & Immunology (1995), 108(1), 19-23

The aim of our study was to determine the effect of a rectocolonic preimmunization with ovalbumin on the systemic immune response induced by a subsequent subcutaneous injection of this antigen in Balb/c ... [more ▼]

The aim of our study was to determine the effect of a rectocolonic preimmunization with ovalbumin on the systemic immune response induced by a subsequent subcutaneous injection of this antigen in Balb/c mice. One rectocolonic, but not intragastric, administration of 25 mg of ovalbumin induced a detectable increase in serum anti-ovalbumin antibody level. The level reached was however much lower than after subcutaneous injection. Both intragastric and rectocolonic immunization with ovalbumin induced specific systemic cellular tolerance. However, after rectocolonic, but not intragastric, preimmunization there was no systemic humoral tolerance to this antigen. These differences in systemic immune responses after rectocolonic or intragastric administration of ovalbumin could be due to different stimulation of the systemic immune system or to differences between the colonic and small bowel mucosal immune system, which remain to be elucidated. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailHypertension artérielle et résistances vasculaires
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Revue Médicale de Liège (1995), 50(9), 365-372

L'anomalie hémodynamique caractéristique de l'hypertension artérielle est l'augmentation des résistances vasculaires. Ces résistances siègent principalement au niveau de petites artères et d'artérioles ... [more ▼]

L'anomalie hémodynamique caractéristique de l'hypertension artérielle est l'augmentation des résistances vasculaires. Ces résistances siègent principalement au niveau de petites artères et d'artérioles précapillaires de diamètre inférieur à 300Il et sont le résultat de modifications essentiellement anatomiques. La média est de loin la couche la plus épaisse de la paroi de ces vaisseaux caractérisés,au stade d'hypertension chronique, par un rapport épaisseur de média sur lumière accru. Contrairement à l'animal hypertendu, cette modification est, chez l'homme, liée à un remodelage vasculaire (réarrangement cellulaire sans vraie hypertrophie ou hyperplasie), en relation avec une anomalie endothéliale (réduction de production de monoxyde d'azote, augmentation de production d'endothéline-l). L'intérêt pour ces modifications structurelles réside dans l'espoir d'influencer favorablement ces lésions notamment par des traitements spécifiques. Récemment, une étude canadienne a rapporté qu'un inhibiteur de l'enzyme de conversion, à même efficacité antihypertensive qu'un bêtabloquant, était seul capable de normaliser les anomalies structurelles de la média et de corriger (partiellement) la dysfonction endothéliale caractérisant également l'hypertendu après 27ms de traitement (étude chez l'homme, à partir de biopsies répétées de tissu sous-cutané, selon la technique proposée par les groupes de Heagerty et Mulvany). Cette observation jointe aux données expérimentales et à quelques données humaines suggère que les inhibiteurs de l'enzyme de conversion posséderaient bien des propriétés indépendantes de leur effet antihypertenseur permettant une correction des anomalies vasculaires dans l'hypertension. Ces travaux méritent cependant une confirmation sur un grand nombre de patients. Ils ont l'intérêt d'ajouter une note explicative pathogénique aux bénéfices déjà observés en épidémiologie dans la décompensation cardiaque, l'infarctus myocardique ou la protection rénale lors de l'utilisation de ces molécules. [less ▲]

Detailed reference viewed: 45 (0 ULg)
Peer Reviewed
See detailLe cas clinique du mois. Rémission spontanée prolongée d'un diabète de type 1 typique
Scheen, A. J.; Letiexhe, M. R.; Paquot, Nicolas ULg et al

in Revue Médicale de Liège (1995), 50(9), 363-4

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailOn the electrochemical polymerization of acrylonitrile and N-vinylpyrrolidone : new insight into the mechanism
Jérôme, Robert ULg; Mertens, Marc; Martinot, Lucien

in Advanced Materials (1995), 7(9), 807-809

The protection of metals against environmental attack can be achieved by coating the metal with a protective organic film. Poor adhesion of the organic film to the metal surface has, however, limited the ... [more ▼]

The protection of metals against environmental attack can be achieved by coating the metal with a protective organic film. Poor adhesion of the organic film to the metal surface has, however, limited the success of this approach. Here it is demonstrated that polyacrylonitride can be elecrografted onto a nickel surface producing a strongly adherent film. The transformation of the organic film could also open the way to new polymer-metal composites. [less ▲]

Detailed reference viewed: 38 (2 ULg)
Peer Reviewed
See detailThe kinetic growth anisotropy of the 123-(RE)BaCuO compounds
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Philosophical Magazine A (1995), 72(3), 727-736

The kinetic growth anisotropy of the melt-textured 123-(RE)BaCuO compounds, especially along the CuCO2 planes, is discussed here in detail. A computer model which simulates the grain growth of 123 ... [more ▼]

The kinetic growth anisotropy of the melt-textured 123-(RE)BaCuO compounds, especially along the CuCO2 planes, is discussed here in detail. A computer model which simulates the grain growth of 123 materials in the ab plane is presented. This kinetic growth model takes some bond anisotropy along the [100] and [110] directions into account. The model presented herein belongs to a hierarchical set of generalized Eden models as discussed in the Appendix. For different bond anisotropy parameters, the simulated 123-(RE)BaCUO grains exhibit square and octogonal overall shape which have been both optically observed. From simple kinetic arguments, we show that the 'faceting' of the 123-(RE)BaCuO grains finds its origin in a bond anisotropy rather than in a growth-rate anisotropy along some crystallographic directions. This is of general interest and opens new perspectives for developing the Eden model in the crystal-growth field. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Peer Reviewed
See detailIncidence and direct social costs of hip fractures from 1984 to 1993 in Belgium
Gillet, Pierre ULg; Reginster, Jean-Yves ULg

in Journal of Bone and Mineral Research (1995)

Detailed reference viewed: 11 (4 ULg)
Full Text
Peer Reviewed
See detailGlycoproteins of the aspartyl proteinase gene family secreted by the developing placenta
Roberts, R. M.; Xie, S.; Nagel, R. J. et al

in Advances in Experimental Medicine and Biology (1995)

Pregnancy in cattle and sheep can be diagnosed by the presence of placentally-derived antigens (pregnancy-associated glycoproteins or PAG-1) in maternal serum soon after implantation begins at about Day ... [more ▼]

Pregnancy in cattle and sheep can be diagnosed by the presence of placentally-derived antigens (pregnancy-associated glycoproteins or PAG-1) in maternal serum soon after implantation begins at about Day 20 following conception. Molecular cloning of their cDNA has revealed that PAG-1 belong to the aspartic proteinase gene family and have about 50% amino acid sequence identity to pepsin. However, critical amino acid substitutions at the active site regions suggest that both bovine and ovine PAG-1 are enzymatically inactive. PAG-1 expression has been shown by in situ hybridization and immunocytochemistry to be localized to the trophoblast binucleate cells, which invade maternal uterine endometrium during implantation. The glycoproteins are concentrated in dense cytoplasmic granules that are discharged after the binucleate cells have migrated to the maternal side of the placental barrier. We suggest, therefore, that the PAG-1 might have an endocrine function either as carriers of other bioactive peptides or by acting as hormones themselves. Recently screening of placental libraries with nucleic acid probes has identified additional cDNA that are very abundant and code for polypeptides (PAG-2 and PAG-3) related to, but antigenically and structurally distinct from PAG-1 described above. These molecules have sequences of amino acids at their catalytic centers that are consistent with their being potentially functional proteinases but their role during pregnancy, like that of PAG-1, is unclear. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Peer Reviewed
See detailSelf-organized criticality in phylogenetic-like tree growths
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal de Physique I (1995), 5(8), 1011-1025

A simple stochastic model of Darwinistic evolution generating phylogenetic-like trees is developed. The model is based on a branching process taking competition-correlation effects into account. In ... [more ▼]

A simple stochastic model of Darwinistic evolution generating phylogenetic-like trees is developed. The model is based on a branching process taking competition-correlation effects into account. In presence of finite and short range correlations, the process self-organizes into a critical steady-state in which intermittent bursts of activity of all sizes are generated. On a geological-like time scale, this behaviour agrees with punctuated equilibrium features of biological evolution. The simulated phylogenetic-like trees are found to be self-similar. The dynamics of the transient regimes show a power law decrease of the order parameter towards the 0(+) value which characterizes an unstable critical state. The genetic range k of competition-correlations between living species is found to be a relevant parameter which determines the universality class of the evolution process. An infinite competition-correlation range destroys however the self-organized critical behaviour. The fractal dimension D-f of the phylogenetic-like trees increases from 2.0 to infinity as k goes from 1 to infinity. The critical exponent tau of avalanche size-distribution decreases from about 3/2 (for k = 1) and reaches about 1.2 for k = 10. A hyperscaling relation seems to relate the various universality classes. Through a mean-field theory, we mention that the evolution process is much more complex than a simple uncorrelated branching process. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
See detailPharma-clinics. Le médicament du mois. La terbinafine (Lamisil)
Pierard, Gérald ULg

in Revue Médicale de Liège (1995), 50(8), 352-3

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailSoluble Interleukin-2 Receptor in Crohn's Disease. Assessment of Disease Activity and Prediction of Relapse
Louis, Edouard ULg; Belaiche, Jacques ULg; Van Kemseke, Catherine ULg et al

in Digestive Diseases & Sciences (1995), 40(8), 1750-6

In Crohn's disease, the activity of the disease is difficult to evaluate and the evolution of the disease is difficult to predict. The soluble interleukin-2 receptor serum level has been reported to ... [more ▼]

In Crohn's disease, the activity of the disease is difficult to evaluate and the evolution of the disease is difficult to predict. The soluble interleukin-2 receptor serum level has been reported to correlate with clinical activity of the disease and with mucosal immune activation. We compared serum soluble interleukin-2 receptor to classical inflammatory markers and other immune parameters in the assessment of clinical disease activity and prediction of relapse in patients with Crohn's disease. Soluble interleukin-2 receptor serum levels correlated well with the Crohn's disease activity index, and multivariate analysis showed that this correlation was independent of the other inflammatory and immune markers. The correlation was not greater, However, than that between some inflammatory markers, such as ESR, and Crohn's disease activity index. Longitudinal follow-up showed that a high soluble interleukin-2 receptor serum level was highly predictive of relapse. Multivariate analysis showed that the soluble interleukin-2 recepteur serum level was complementary to other inflammatory and clinical markers in the prediction of relapse of disease. We conclude that soluble interleukin-2 receptor is of use in monitoring Crohn's disease, particularly in prediction of relapse. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailCytogenetic study of bovine oocytes matured in vitro
Ectors, Fabien ULg; Koulischer, Lucien ULg; Jamar, M. et al

in Theriogenology (1995), 44(3), 445-450

Described in the present paper is a cytogenetic study of bovine oocytes matured in vitro. The cumulus-oocyte complexes (COC), punctured from ovaries recovered in a local slaughterhouse, were classified ... [more ▼]

Described in the present paper is a cytogenetic study of bovine oocytes matured in vitro. The cumulus-oocyte complexes (COC), punctured from ovaries recovered in a local slaughterhouse, were classified into 3 groups according to follicular diameter 1 to 4mm, 5 to 8mm and 9 to 13 mm. Metaphases available for observation were classified as metaphase I, haploid and diploid metaphase II. High levels of haploid metaphases II (90.6, 86.9 and 94.4 %) among the 3 groups of follicular sizes indicated successful meiotic resumption during in vitro maturation and suggested that cytoplasmic maturation may be responsible for low developmental rate after IVM, IVF and in vitro development (IVD). [less ▲]

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailPurification of Progelatinases A and B by Continuous-Elution Electrophoresis
Remacle, A. G.; Baramova, E. N.; Weidle, U. H. et al

in Protein Expression & Purification (1995), 6(4), 417-22

Progelatinases A and B were purified from HT1080-conditioned culture medium using a continuous-elution electrophoresis. Initially cell culture medium was ammonium sulfate precipitated. The concentrated ... [more ▼]

Progelatinases A and B were purified from HT1080-conditioned culture medium using a continuous-elution electrophoresis. Initially cell culture medium was ammonium sulfate precipitated. The concentrated proteins were affinity chromatographed on gelatin-Sepharose column. The bound gelatinases were eluted with electrophoresis sample buffer and subjected to continuous-elution electrophoresis. In a single run, under the standardized working conditions, the obtained fractions contained four purified enzymes--progelatinase A (M(r) 72,000), its activated forms (M(r) 62,000 and M(r) 59,000), and progelatinase B (M(r) 92,000). Moreover, the continuous-elution electrophoresis allowed the enzymes separation from their respective inhibitors--TIMP-1 (M(r) 28,500) and TIMP-2 (M(r) 21,000). The purified progelatinases A and B demonstrated high specific activities (150-200 U/micrograms). [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailDetection of Nucleic Acids in the Attomole Range Using Polybiotinylated Oligonucleotide Probes
Zecchini, Vincent; Caucheteux, Danièle; Gretry, Jeau et al

in BioTechniques (1995), 19(2), 286-90

This article describes the optimization of the hybridization signal obtained with biotinylated oligonucleotides. Optimal number and positions of biotin moieties on a 33-base oligonucleotide probe were ... [more ▼]

This article describes the optimization of the hybridization signal obtained with biotinylated oligonucleotides. Optimal number and positions of biotin moieties on a 33-base oligonucleotide probe were determined. The quality of avidin-peroxidase conjugate and the choice of chromogenic substrate influenced detection sensitivity. A signal amplification method was also developed for avidin enzymatic conjugates. These improvements allowed the detection of less than 0.02 fmol of target DNA. [less ▲]

Detailed reference viewed: 8 (2 ULg)
Peer Reviewed
See detailApproaches to the optimal navigation organization on the inland waterway network
Marchal, Jean ULg; Zhang, Z. M.

in Procceedings of the First Symposium on Operation Research with Application in Engineering, Technology and Management (ISORA’95) (1995)

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailMicroencapsulation by coacervation of poly(lactide-co-glycolide). IV. Effect of the processing parameters on coacervation and encapsulation
Nihant, N.; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Controlled Release (1995), 35(2-3), 117-125

Attention has been paid to phase separation of poly (lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of a silicone oil in order to promote protein microencapsulation. Since the process ... [more ▼]

Attention has been paid to phase separation of poly (lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of a silicone oil in order to promote protein microencapsulation. Since the process is very fast, the system is anytime out of equilibrium. The effect of the main processing parameters on the microencapsulation process has been analyzed and has highlighted that kinetics of the main encapsulation steps has a great effect on the characteristics of the final microspheres. These results have been discussed on the basis of a physico-chemical study of coacervation reported in previous papers of this series. [less ▲]

Detailed reference viewed: 95 (4 ULg)
Full Text
Peer Reviewed
See detailAggregation behavior of ω- and α,ω-metal sulfonato polystyrene in toluene
Vanhoorne, Pierre ULg; Jérôme, Robert ULg

in Macromolecules (1995), 28(16), 5664-5670

The aggregation behavior of omega- and alpha,omega-metal sulfonato polystyrene in toluene has been investigated by static and dynamic light scattering. Monofunctional chains reversibly associate into ... [more ▼]

The aggregation behavior of omega- and alpha,omega-metal sulfonato polystyrene in toluene has been investigated by static and dynamic light scattering. Monofunctional chains reversibly associate into small reverse micelles. Lithium-based ionic aggregates contain an average of 12 ion pairs, which corresponds to a preferential structure for the ionic cores. When the molecular weight of the chains is increased, polymer-solvent interactions progressively distort the ionic aggregates, and above a critical molecular weight, estimated to be 50000 in toluene, the multiplets collapse into smaller aggregates of an average of 3 ion pairs. Traces of polar solvents do not strongly affect the aggregation number, but do weaken the dipole-dipole interactions. Structure of the ionic cores strongly depends on the nature of the ion pairs, which suggests that this structural feature is a key parameter in the control of the structure-property relationships in ionomers. The aggregation behavior of the difunctional chains is complex, due to the occurrence of a closed association mechanism for the individual multiplets and an open association of reverse micelles into larger aggregates. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailAPRIL 1993 ARCTIC PROFILES OF STRATOSPHERIC HCL, CLONO2, AND CCL2F2 FROM ATMOSPHERIC TRACE MOLECULE SPECTROSCOPY ATLAS 2 INFRARED SOLAR OCCULTATION SPECTRA
Rinsland, C. P.; Gunson, M. R.; Abrams, M. C. et al

in Journal of Geophysical Research (1995), 100(D7), 14019-14027

Partitioning among the major components of the stratospheric odd chlorine family inside and outside of the remanent Arctic vortex has been studied on the basis of infrared solar occultation measurements ... [more ▼]

Partitioning among the major components of the stratospheric odd chlorine family inside and outside of the remanent Arctic vortex has been studied on the basis of infrared solar occultation measurements obtained by the atmospheric trace molecule spectroscopy (ATMOS) Fourier transform spectrometer during the ATLAS 2 shuttle mission (April 8-17, 1993). Profiles of hydrogen chloride (HCl) and simultaneous profiles of chlorine nitrate (ClONO2) and CFC-12 (CCl2F2) are reported for examples of in-vortex and out-of-vortex conditions. Increased ClONO2 volume-mixing ratios (VMRs) are measured in the vortex below 20 mbar (similar to 25 km altitude) with a peak ClONO2 VMR of 2.05 +/- 0.45 ppbv (10(-9) per volume) at 56 mbar (similar to 19 km altitude). The reported error correspond to la uncertainties. Simultaneous CCl2F2 and N2O measurements, combined with published empirical relations, indicate that only 0.34 +/- 0.15 ppbv, about 10% of total chlorine, was bound in organic species at the ClONO2 VMR peak in the vortex. A colocated vortex profile of HCl, referenced to simultaneous N2O VMR measurements, has been used to derive a HCl mixing ratio of 1.21 +/- 0.12 ppbv corresponding to the ClONO2 VMR peak. The internal consistency of the ATMOS measurements is demonstrated by the agreement between the total chlorine mixing ratio of 3.60 +/- 0.72 ppbv derived at the ClONO2 VMR peak in the vortex and HCl measurements of 3.37 +/- 0.37 and 3.76 +/- 0.41 ppbv at 0.56 mbar, where HCl is the only significant chlorine-bearing molecule. Outside the vortex the mixing ratio of HCl exceeds the mixing ratio of ClONO2 throughout the stratosphere. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailBlends of biphasic ionomers with chemically identical mono- and bifunctional oligomers
Plante, Michel; Bazuin, C Géraldine; Jérôme, Robert ULg

in Macromolecules (1995), 28(15), 5240-5247

Biphasic Cs and Ba carboxylated polystyrene ionomers were blended with chemically identical mono- and bifunctional oligomers whose chain lengths are significantly greater than the average segmental length ... [more ▼]

Biphasic Cs and Ba carboxylated polystyrene ionomers were blended with chemically identical mono- and bifunctional oligomers whose chain lengths are significantly greater than the average segmental length between ionic groups in the ionomer. The ionomers were chosen to have two ion contents such that, in one case, the matrix phase is dominant and, in the other, the cluster phase is dominant. From dynamic mechanical thermal analysis, it was observed that the biphasic morphology of the ionomers is preserved in all blends (containing up to 60 wt % oligomer). The monofunctional oligomers tend to have a mild plasticizing action on the two phases. In the matrix-dominated ionomer, the bifunctional oligomer has an antiplasticization effect at lower oligomer contents; this is attributed to a greater dispersion of ionic aggregates in the matrix phase, accompanied by pinning of the oligomer extremities in multiplets, which prevents plasticizing action. In the cluster-dominated ionomer, the oligomer forms a separate phase, which is related to insufficiently large ion-poor styrene regions in the ionomer to accommodate the long nonionic portion of the oligomer chains. [less ▲]

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detailStereocomplexation and morphology of polylactides
Brochu, Sylvie; Prud'homme, Robert E; Barakat, Ibrahim et al

in Macromolecules (1995), 28(15), 5230-5239

Blends of isotactic polylactides of opposite configurations lead to the formation of stereocomplexes, provided the enantiomeric excess of the two homopolymers in contact is high enough. In this study, the ... [more ▼]

Blends of isotactic polylactides of opposite configurations lead to the formation of stereocomplexes, provided the enantiomeric excess of the two homopolymers in contact is high enough. In this study, the stereocomplex formation between a poly(L-lactide) (100L) having an enantiomeric excess of 100% and a poly(D-lactide) having an enantiomeric excess of 80% (80D) has been investigated using differential scanning calorimetry and optical microscopy. These results have been compared to those obtained between two polylactides having both an enantiomeric excess of 100% (100L/100D blend). The melting temperatures of blends 100L/100D and 100L/80D are 230 and 208 degrees C, respectively. In both cases, the stereocomplex formation is preferred to the homopolymer crystallization and the stereocomplex controls the morphology of the blends over a wide range of concentrations. However, this control is more rigorous when the D component is 100% isotactic. This difference leads to a more complete crystallization of homopolymer 100L and to a greater influence of crystallization conditions in 100L/80D blends in comparison with 100L/100D blends. An epitaxial crystallization between the homopolymer 100L and the stereocomplex 100L/80D has also been observed at certain compositions. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailLatent Bovine Herpesvirus 1 Infection in Calves Protected by Colostral Immunity
Lemaire, Mylène; Meyer, Gilles; Ernst, E. et al

in Veterinary Record : Journal of the British Veterinary Association (1995), 137(3), 70-1

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailHeterogeneity of sponastrime dysplasia: Delineation of a variant form with severe mental retardation
Verloes, Alain ULg; Misson, Jean-Paul ULg; Dubru, J. M. et al

in Clinical Dysmorphology (1995), 4(3), 208-215

We report a child with short stature, osteopenia with metaphyseal striations and severe mental retardation. This child shows radiological and clinical features of SPONASTRIME dysplasia. Only three ... [more ▼]

We report a child with short stature, osteopenia with metaphyseal striations and severe mental retardation. This child shows radiological and clinical features of SPONASTRIME dysplasia. Only three sibships with this disorder have been reported. In two families, affected patients were of normal intelligence. In the third one, as well as our case, the dysplasia was complicated by severe mental retardation of unknown origin. The severity of the retardation in our case and a previous report, and some difference in the gestalt and radiological aspects, suggest that SPONASTRIME dysplasia is a heterogeneous disorder. We provisionally propose to split SPONASTRIME dysplasia in two phenotypically distinct subgroups, and to delineate here a 'new' variant with microcephaly and severe mental impairment. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailPolylactide microparticles prepared by double emulsion-evaporation 2 : Effect of the poly(lactide-co-glycolide) composition on the stability of the primary and secondary emulsions
Nihant, Nicole; Schugens, Chantal; Grandfils, Christian ULg et al

in Journal of Colloid and Interface Science (1995), 173(1), 55-65

Polylactide and copolymers with glycolide have been used as coating polymers in the microencapsulation technique based on the W1/o/w2 double emulsion-evaporation method. Stability of the primary emulsion ... [more ▼]

Polylactide and copolymers with glycolide have been used as coating polymers in the microencapsulation technique based on the W1/o/w2 double emulsion-evaporation method. Stability of the primary emulsion is of critical importance and clearly predetermines the internal morphology of the microspheres, in agreement with the very fast hardening of the oil phase (CH2Cl2) as soon as the primary emulsion is dispersed in water. When the peptide or' protein to be encapsulated is able to interact with the coating polymer and possibly with the surfactant, the stabilization mechanism of the primary emulsion is very complex. It has been shown that the interaction of BSA (bovine serum albumin) with the polyester is as strong as the glycolide content is high, which results in the formation of a solid film at the w1/o interface and in a high emulsion stability. Addition of a surfactant, such as poloxamer 188, in the oil phase has a deleterious effect on both the emulsion stability and the internal structure of the microspheres. Use of a dye tracer in the internal aqueous phase was not useful in probing the double emulsion stability and the encapsulation efficiency, because of specific interactions between the dye (indigocarmine) and the coating polyester. [less ▲]

Detailed reference viewed: 103 (8 ULg)
Full Text
Peer Reviewed
See detailControl of living anionic polymerization of (meth)acrylates : active complex species, macromolecular engineering and possible scaling-up
Teyssié, Philippe; Bayard, Philippe; Jérôme, Robert ULg et al

in Macromolecular Symposia (1995), 98

Tailored polymerization of acrylic and methacrylic esters, particularly methyl methacrylate (MMA), has been the topic of a frantic research effort during the last decade. It is the purpose of this paper ... [more ▼]

Tailored polymerization of acrylic and methacrylic esters, particularly methyl methacrylate (MMA), has been the topic of a frantic research effort during the last decade. It is the purpose of this paper to present one of the main lines of that quest, and to evaluate its potential versus other new approaches. [less ▲]

Detailed reference viewed: 46 (2 ULg)
Full Text
Peer Reviewed
See detailThe gene encoding bovine pregnancy-associated glycoprotein-1, an inactive member of the aspartic proteinase family
Xie, S.; Green, J.; Beckers, Jean-François ULg et al

in Gene (1995), 159(2), 193-197

Bovine pregnancy-associated glycoprotein 1 (bPAG1) is a member of the aspartic proteinase family. It becomes detectable in maternal serum soon after implantation and is produced specifically in the ... [more ▼]

Bovine pregnancy-associated glycoprotein 1 (bPAG1) is a member of the aspartic proteinase family. It becomes detectable in maternal serum soon after implantation and is produced specifically in the invasive binucleate cells of the placenta. As a result of a key mutation within its catalytic center, bPAG1 appears to be proteolytically inactive. Its gene consists of nine exons (size range 99-281 bp) and eight introns (87-1800 bp) organized in a manner very similar to those of proteolytically active mammalian aspartic proteinases. The transcription start point (tsp) is located 53 or 54 bp upstream from the start codon (ATG) and 19 bp downstream from a 5'-TATATAA sequence. Southern blot analyses have indicated the presence of two bPAG1 genes. By screening with an antiserum raised against bPAG1, a less common cDNA with 91% sequence identity to the bPAG1 transcript has been isolated from a placental cDNA library and presumably represents the second gene. At least eight other genes with sequences that hybridize relatively weakly to the bPAG1 probe are present in the bovine genome. Despite the similarities in the transcribed portion of the genes encoding PAG1, pepsinogen and other mammalian aspartic proteinases, the sequences upstream from the tsp of bPAG1 are unique. [less ▲]

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailFractionation and partial characterization of proteins extracted from the bovine fallopian tube: preparation of tools for further purifications
Remy, Benoît ULg; Rabahi, F.; Duwez, L. et al

in Theriogenology (1995), 44(1), 95-107

Described in the present paper is a combined biochemical and immunological approach to study oviductal proteins in the bovine. Antisera were raised against semi-purified proteins extracted from bovine ... [more ▼]

Described in the present paper is a combined biochemical and immunological approach to study oviductal proteins in the bovine. Antisera were raised against semi-purified proteins extracted from bovine tubal mucosal tissue and were characterized. These antisera are available to monitor puritications of specific oviductal proteins in the future. Oviducts from 170 cyclic cows were collected at a slaughterhouse, and high amounts of mucosal proteins were extracted. The proteins were fractionated after precipitation with ammonium sulfate, anti-bovine serum albumin (bSA) and anti-bovine immunoglobulins bIg) afiinity chromatography and ion exchange chromatography. Each of the 12 fractions obtained after ion exchange chromatography was used to immunize a rabbit. Conditioned media were recovered from bovine oviduct cell monolayers cultured without serum to cot&m the oviductal origin of the extracted proteins. After Western blot analysis, 15 proteins were detected in the bovine oviductal extracts, and their molecular weights and isoelectric points were determined by 2 dimensional electrophoresis. Among these 15 proteins, 11 were also detected in conditioned media of bovine oviductal cells. These results demonstrate an oviductal origin of the 11 detected proteins and strongly suggest their secretion by the oviductal cells. [less ▲]

Detailed reference viewed: 39 (1 ULg)
Full Text
Peer Reviewed
See detailAnalysis of Bovine Herpesvirus 4 Genomic Regions Located Outside the Conserved Gammaherpesvirus Gene Blocks
Lomonte, P.; Bublot, M.; van Santen, V. et al

in Journal of General Virology (The) (1995), 76((Pt 7)), 1835-41

Bovine herpesvirus 4 (BHV-4) DNA sequences located outside the gene blocks conserved among the gammaherpesviruses BHV-4, herpesvirus saimiri (HVS) and Epstein-Barr virus (EBV) were analysed. Twelve ... [more ▼]

Bovine herpesvirus 4 (BHV-4) DNA sequences located outside the gene blocks conserved among the gammaherpesviruses BHV-4, herpesvirus saimiri (HVS) and Epstein-Barr virus (EBV) were analysed. Twelve potential open reading frames (ORFs) were found. Protein database comparisons showed that no ORF translation products were similar to proteins encoded by alpha- or betaherpesviruses. Nevertheless, six of the ORFs were homologous in amino acid sequences to proteins encoded by HVS but apparently not to those encoded by EBV. Furthermore, the location and orientation of these six ORFs in the BHV-4 genome were similar to the corresponding ORFs in the HVS genome. No genes homologous to known cellular genes were found in the BHV-4 genome; this feature is the major difference between the BHV-4 and HVS genomes with regards to the overall gene content. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailElectrical conductivity in carbon black-loaded polystyrene-polyisoprene blends. Selective localization of carbon black at the interface
Soares, Bluma G; Gubbels, Frédéric; Jérôme, Robert ULg et al

in Polymer Bulletin (1995), 35(1-2), 223-228

The electrical conductivity of carbon-black loaded polystyrene-polyisoprene blends has been studied. In this ternary system, the filler is at the interface of co-continuous polyblends as confirmed by the ... [more ▼]

The electrical conductivity of carbon-black loaded polystyrene-polyisoprene blends has been studied. In this ternary system, the filler is at the interface of co-continuous polyblends as confirmed by the very low value of the filler percolation threshold (0.2 vol % for blends compression molded at 250 degrees C) and by optical microscopy. As a result of the selective localization of carbon black at the interface, the percolation threshold is very sensitive to the compression molding temperature. [less ▲]

Detailed reference viewed: 104 (1 ULg)
Peer Reviewed
See detailL'endocardite infectieuse. Concepts actuels
LANCELLOTTI, Patrizio ULg; Pierard, Luc ULg

in Revue Médicale de Liège (1995), 50(7), 281-5

Detailed reference viewed: 16 (7 ULg)
Full Text
Peer Reviewed
See detailSubstituent effect in anionic polymerization of β-lactones initiated by alkali metal alkoxides
Kurcok, Piotr; Matuszowicz, Andrzej; Jedlinski, Zbigniew et al

in Macromolecular Rapid Communications (1995), 16(7), 513-519

The influence of methyl substituent on the mechanism of the ring-opening polymerization of -lactones initiated by alkali metal alkoxides is discussed. Attention has been paid to the effect of the ... [more ▼]

The influence of methyl substituent on the mechanism of the ring-opening polymerization of -lactones initiated by alkali metal alkoxides is discussed. Attention has been paid to the effect of the substituent position in the monomer molecule on the ring-opening mechanism, the 3,3-dimethyl-2-oxetanone (pivalolactone), 4-methyl-2-oxetanone (beta-butyrolactone) and 2-oxetanone (beta-propiolactone) being chosen as model monomers. Moreover, it was found unexpectedly that in the case of pivalolactone polymerization, besides open-chain polymers, cyclic oligomers are produced. [less ▲]

Detailed reference viewed: 125 (3 ULg)
Full Text
Peer Reviewed
See detailEffects of fetal bovine serum, FSH and 17ß-Estradiol on the culture of bovine preantral follicles
Hulshof, S. C. J.; Figueiredo, J. R.; Beckers, Jean-François ULg et al

in Theriogenology (1995), 44(2), 217-226

We describe a 7-d culture in droplets of collagen gel of isolated small bovine preantral follicles in medium with or without 10% fetal bovine serum (FBS). In addition, the effect of human recombinant FSH ... [more ▼]

We describe a 7-d culture in droplets of collagen gel of isolated small bovine preantral follicles in medium with or without 10% fetal bovine serum (FBS). In addition, the effect of human recombinant FSH and 17beta-estradiol on the morphology and growth of the preantral follicles was investigated in medium without FBS. After culture in medium with 10% FBS, the increase in follicle diameter was 13.1 +/- 8.4 microm, the percentage of BrdU-labeled cells was 49.9 +/- 11.3 and the number of cells per area granulosa was 11.1 +/- 1.8. Omission of serum from the culture medium had no effect on the percentage of labeled cells, but the diameter increase was lower and the cells were smaller. Apparently, serum affects the size of the granulosa cells from small preantral follicles rather than the stimulation of cell proliferation. Addition of human recombinant FSH and/or 17beta-estradiol to serum-free medium resulted in a larger diameter increase during culture compared with that of the control. With FSH, this was due to an increase in cell proliferation, while with estradiol this was caused by an increase in granulosa cell size. The effects of simultaneous treatment with FSH and estradiol was simply the combination of their individual effects. In conclusion, small bovine preantral follicles can be cultured for 7 d in the absence of serum and hormones. The follicles increase in diameter and react to FSH with enhanced cell proliferation and to estradiol with an increase in cell size. [less ▲]

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detailOrganisation spatiale et génération de mobilité
Hanocq, Philippe ULg

in Cahiers de l'Urbanisme (Les) (1995), 13-14

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailDiaspirin Crosslinked Hemoglobin (Dclhb): Absence of Increased Free Radical Generation Following Administration in a Rabbit Model of Renal Ischemia and Reperfusion
Pincemail, Joël ULg; Detry, Olivier ULg; Philippart, C. et al

in Free Radical Biology & Medicine (1995), 19(1), 1-9

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free ... [more ▼]

In control rabbits, a renal ischemia of 60 min followed by 10 min of reperfusion resulted in an enhanced free radical production in cortical tissue, as assessed by a significant decrease of free glutathione (42%), protein-bound GSH (17%), and vitamin E (49%). In contrast, catalase or glutathione peroxidase activities were not affected by these experimental conditions. Free radical production in this model was also measured directly using electron spin resonance (ESR) spectroscopy associated with a PBN (alpha-phenyl N-tert-butyl-nitrone) spin trap agent in the venous blood arising from the ischemic kidney. The signal consisted of a triplet of doublets. In contrast, no signal could be detected in control blood samples taken prior to inducing ischemia. The burst of free radical production occurred in the early phase after restoration of flow in the kidneys rendered ischemic, as evidenced by a signal of weak intensity which generally appeared within the third minute after reperfusion and progressively increased to form a well-defined asymmetric signal following 10 min of reperfusion. The precise nature of free radicals trapped by the PBN agent remains, however, to be elucidated, but analysis of the coupling constants (aN = 14.5-15 G; a beta H = 2.5-3 G) and asymmetry of the central doublets suggests that the ESR signal may arise from a nitorxy-radical adduct resulting from the spin trapping by PBN of both oxygen- or carbon-centered radicals of lipid origin. As evidenced by both direct and indirect measurements, exchange of rabbit blood immediately after inducing renal ischemia with 30 ml/kg of Diaspirin Crosslinked Hemoglobin (7.5 g/dl in lactated electrolyte) or human serum albumin (7.5 g/dl in lactated electrolyte) did not exacerbate free radical production mediated by an ischemia reperfusion phenomenon, a typical situation found in a resuscitation setting. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Full Text
Peer Reviewed
See detailEffect of Inducers and Pcbs on the Cytochrome P450 Enzymes in Cultured Quail Hepatocytes
Roelandt, L.; Dubois, Maryline; Todaro, Anna ULg et al

in Ecotoxicology & Environmental Safety (1995), 31(2), 158-63

Hepatocytes isolated from fetal quail livers (Coturnix coturnix japonica) were cultured in vitro. Their capacity to metabolize drugs and xenobiotics was explored with typical cytochrome P450 substrates ... [more ▼]

Hepatocytes isolated from fetal quail livers (Coturnix coturnix japonica) were cultured in vitro. Their capacity to metabolize drugs and xenobiotics was explored with typical cytochrome P450 substrates: ethoxycoumarin (known to be metabolized by several P450s), ethoxyresorufin (essentially dealkylated by P450IA1), and testosterone (specifically hydroxylated at several positions by several P450s). The cells could be kept metabolically active in culture for at least 4 days. Their drug-metabolizing activities were inducible by the usual P450 inducers, like phenobarbital and benzanthracene, but also by Aroclor 1254, a PCB mixture. The results obtained indicate that this experimental model could certainly be very helpful in ecotoxicological studies. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailNuclear Lesions During Rat Hepatocarcinogenesis. II. Measuring the Micronuclei During Initiation, Promotion and Progression of Rat Hepatocarcinogenesis Induced with Diethylnitrosamine
Herens, Christian ULg; Massart, Sandrina ULg; Bouzahzah, B. et al

in Mutation Research : Fundamental & Molecular Mechanisms of Mutagenesis (1995), 329(2), 161-71

We reported in our companion paper the strong correlation between elevated sister-chromatid exchange (SCE) frequencies and the initiation step of rat hepatocarcinogenesis. We have also shown that SCEs ... [more ▼]

We reported in our companion paper the strong correlation between elevated sister-chromatid exchange (SCE) frequencies and the initiation step of rat hepatocarcinogenesis. We have also shown that SCEs return to normal values during the promotion and the progression stages. In the present study, we evaluated the clastogenic activity of diethylnitrosamine (DEN) during initiation, promotion and progression of rat hepatocarcinogenesis. We measured, at various times after DEN administration, the number of micronuclei (MN) produced by the mitotic response to partial hepatectomy. The results established that the DEN treatment induces a great number of preclastogenic lesions. In subcarcinogenic conditions (initiation alone), the number of MN expressed after partial hepatectomy remains high regardless of the time interval between the end of the DEN treatment and the operation. In this condition, the preclastogenic lesions persist for up to 1 year after the DEN administration is discontinued. Conversely, in carcinogenic conditions (initiation + promotion + progression), the number of MN expressed after partial hepatectomy decreases during the promotion and progression stages. These observations indicate that promotion and progression but not initiation are associated with the expression of persistent preclastogenic lesions, resulting in the production of chromosomally abnormal hepatocytes. [less ▲]

Detailed reference viewed: 6 (2 ULg)
Peer Reviewed
See detailNuclear Lesions During Rat Hepatocarcinogenesis. I. Measuring the Sister-Chromatid Exchanges During Initiation, Promotion and Progression of Rat Hepatocarcinogenesis Induced with Diethylnitrosamine
Herens, Christian ULg; Jacquemart, M.; Koulischer, Lucien ULg et al

in Mutation Research : Fundamental & Molecular Mechanisms of Mutagenesis (1995), 329(2), 153-9

Cytogenetic endpoints such as sister-chromatid exchanges (SCEs), chromosomal aberrations and micronuclei (MNs) have been widely used as indicators of genetic damage. However, no systematic attempts have ... [more ▼]

Cytogenetic endpoints such as sister-chromatid exchanges (SCEs), chromosomal aberrations and micronuclei (MNs) have been widely used as indicators of genetic damage. However, no systematic attempts have been made to correlate the levels of these cytogenetic endpoints with the different steps of carcinogenesis. In the present report, the induction, accumulation and persistence of SCEs and high frequency cells (HFCs) were measured in liver cells during the initiation, promotion and progression steps of rat hepatocarcinogenesis induced by diethylnitrosamine (DEN). The results indicate that lesions leading to SCEs accumulate during initiation only. When DEN administration is longer than the duration of this first step, SCE values stabilize. After stopping the carcinogenic treatment, the SCE levels decrease to control values whether or not promotion and progression occur. [less ▲]

Detailed reference viewed: 16 (4 ULg)
Full Text
Peer Reviewed
See detailHydrogen Peroxide Hyperpolarizes Rat Ca1 Pyramidal Neurons by Inducing an Increase in Potassium Conductance
Seutin, Vincent ULg; Scuvée-Moreau, Jacqueline ULg; Massotte, Laurent ULg et al

in Brain Research (1995), 683(2), 275-8

It has been suggested that hydrogen peroxide is involved in cascades of pathological events affecting neural cells. The aim of this study was therefore to examine whether this molecule is able by itself ... [more ▼]

It has been suggested that hydrogen peroxide is involved in cascades of pathological events affecting neural cells. The aim of this study was therefore to examine whether this molecule is able by itself to modify membrane properties of pyramidal neurons in the CA1 region of the rat hippocampus. Intracellular recordings in the slice preparation showed that 3.3 mM hydrogen peroxide hyperpolarized all neurons tested (n = 41) by 11 +/- 3 mV. This effect persisted in the presence of tetrodotoxin. It developed slowly, was reversible and reproducible. In the presence of tetrodotoxin, the extrapolated reversal potential of this effect was -95 +/- 5 mV in 2.5 mM external potassium. This value was not significantly different from the one obtained with the GABAB agonist baclofen (10 microM) (-98 +/- 5 mV). It shifted when the concentration of external potassium was increased to 10.5 mM (from -96 +/- 5 to -62 +/- 4 mV), in close agreement with the Nernst equation potassium ions. The hyperpolarization was significantly reduced (by 65 +/- 22%) by the potassium channel blocker barium (100 microM). We suggest that hydrogen peroxide is able to induce an increase in potassium conductance in rat CA1 pyramidal neurons. The exact mechanism by which it produces this effect (direct action on channels or indirect effect) remains to be determined. [less ▲]

Detailed reference viewed: 30 (15 ULg)
Full Text
Peer Reviewed
See detailReconstitution of yeast nucelotide excision repair with purified RAD proteins, replication protein A and transcription factor TFIIH
Guzder, Sami; Habraken, Yvette ULg; Sung, Patrick et al

in Journal of Biological Chemistry (1995), 270(22), 12973-6

Detailed reference viewed: 2 (0 ULg)
See detailNomenclature stellaire et catalogues astronomiques - VIII.
Manfroid, Jean ULg; Renson, Pierre ULg

in Ciel (Le) (1995), 57

Not Available

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailLa maladie à virus Ebola, une fièvre hémorragique tropicale
Pierard, Gérald ULg

in Revue Médicale de Liège (1995), 50(6), 241-3

Detailed reference viewed: 10 (3 ULg)
Full Text
Peer Reviewed
See detailPerianal basal cell carcinoma
Kort, Rim; Fazaa, Becima; Bouden, Samira et al

in International Journal of Dermatology (1995), 34(6), 427-428

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailGuidelines for Trials of Drug Treatments in Tension-Type Headache. First Edition: International Headache Society Committee on Clinical Trials
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1995), 15(3), 165-79

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailDistribution of varicella-zoster virus gpI and gpII and corresponding genome sequences in the skin
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Debrus, S. et al

in Journal of Medical Virology (1995), 46(2), 91-96

In the course of varicella-zoster virus (VZV) infection, some viral capsid antigens are found in the epidermis and dermis. The aim of this study was to investigate the localisation of two major VZV ... [more ▼]

In the course of varicella-zoster virus (VZV) infection, some viral capsid antigens are found in the epidermis and dermis. The aim of this study was to investigate the localisation of two major VZV glycoproteins (gpI and gpII) and of their respective genes in the skin. The distribution of VZV gpI and II in 27 formalin fixed paraffin embedded skin biopsies from herpes tester eruptions were compared by immunohistochemistry. Double immunostaining was carried our to identify infected cells. The presence of viral nucleic acids coding for gpI and gpII was examined by in situ hybridisation. The distribution of gpI and gpII and their corresponding genome sequences was similar in the epidermis, gpI and gpII were also detected in dermal FXIIIa positive dendrocytes, in Mac 387 and CD68 positive macrophages, and in perineural and endothelial cells. However, the corresponding viral nucleic acids were rarely and barely detected in these cells of the dermis. It is concluded that VZV infection of epithelial cells follows a different course than in dermal cells. (C) 1995 Wiley-Liss, Inc. [less ▲]

Detailed reference viewed: 42 (10 ULg)
Full Text
Peer Reviewed
See detailAromatase-Immunoreactive Cells Are Present in Mouse Brain Areas That Are Known to Express High Levels of Aromatase Activity
Foidart, Agnès ULg; Harada, N.; Balthazart, Jacques ULg

in Cell & Tissue Research (1995), 280(3), 561-74

The transformation of testosterone into estradiol in the brain plays a key role in several behavioral and physiological processes, but it has been so far impossible to localize precisely the cells of the ... [more ▼]

The transformation of testosterone into estradiol in the brain plays a key role in several behavioral and physiological processes, but it has been so far impossible to localize precisely the cells of the mammalian brain containing the relevant enzyme, viz., aromatase. We have recently established an immunohistochemical technique that allows the visualization of aromatase-immunoreactive cells in the quail brain. In this species, a marked increase in the optical density of aromatase-immunoreactive cells is observed in subjects that have been treated with the aromatase inhibitor, R76713 or racemic Vorozole. This increased immunoreactivity, associated with a total blockade of aromatase activity, has been used as a tool in the present study in which the distribution of aromatase-immunoreactive material has been reassessed in the brain of mice pretreated with R76713. As expected, the aromatase inhibitor increases the density of the immunoreactive signal in mice. Strongly immunoreactive cells are found in the lateral septal region, the bed nucleus of the stria terminalis, the central amygdala, and the dorso-lateral hypothalamus. A less dense signal is also present in the medial preoptic area, the nucleus accumbens, several hypothalamic nuclei (e.g., paraventricular and ventromedial nuclei), all divisions of the amygdala, and several regions of the cortex, especially the cortex piriformis. These data demonstrate that, contrary to previous claims, aromatase-immunoreactive cells are present in all brain regions that have been shown previously to contain high aromatase activity. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailPrevention of Postmenopausal Bone Loss by Rectal Calcitonin
Reginster, Jean-Yves ULg; Jupsin, Isabelle ULg; Deroisy, Rita ULg et al

in Calcified Tissue International (1995), 56

A group (150) of healthy women, who had been menopausal for less than 5 years and who had never received any form of treatment to prevent bone loss were entered into a randomized, controlled study ... [more ▼]

A group (150) of healthy women, who had been menopausal for less than 5 years and who had never received any form of treatment to prevent bone loss were entered into a randomized, controlled study comprising three arms. They were randomly allocated to the double-blind administration of five suppositories per week containing either 100 IU of salmon calcitonin or a placebo, or to a group receiving a suppository containing 200 IU of salmon calcitonin three times per week. All women received 500 mg/day of calcium supplementation. After 12 months, bone mineral density (BMD) of the spine, measured by dual energy X-ray absorptiometry, decreased significantly (P < 0.01) in the placebo group by 3.1% (SD: 3.6%) but did not change in the two calcitonin groups [+1.3% (3.5%) with 100 IU/day and +2.3% (4.0%) with 200 IU 3/week]. The differences in response between the placebo group and the two calcitonin groups were significant (P < 0.05), but the difference between the two regimens of calcitonin administration was not. No differences appeared among the three groups for the response at the level of the hip. Evolution of biochemical markers reflecting bone turnover did not differ significantly among groups. Nearly 40% of the women withdrew prematurely because of local (rectal or intestinal) intolerance to repetitive suppositories, with a nonsignificantly different frequency in the placebo or calcitonin groups. We conclude that rectal calcitonin might be an interesting preventive approach against trabecular postmenopausal bone loss but that long-term acceptability of suppositories should be evaluated in view of each patient's sensibility or cultural background. [less ▲]

Detailed reference viewed: 6 (2 ULg)
Full Text
Peer Reviewed
See detailAppetitive as Well as Consummatory Aspects of Male Sexual Behavior in Quail Are Activated by Androgens and Estrogens
Balthazart, Jacques ULg; Reid, J.; Absil, Philippe ULg et al

in Behavioral Neuroscience (1995), 109(3), 485-501

Appetitive male sexual behavior was measured in male quail with the use of a learned social proximity procedure that quantified the time spent by a male in front of a window providing a view of a female ... [more ▼]

Appetitive male sexual behavior was measured in male quail with the use of a learned social proximity procedure that quantified the time spent by a male in front of a window providing a view of a female that was subsequently released into the cage, providing an opportunity for copulation. The learned response is not acquired by castrated males but can be acquired when castrates are treated with testosterone (T) or with the synthetic estrogen diethylstilbestrol or with the endogenous estrogen 17 beta-estradiol. Only birds that become sexually active acquire the response. Conversely, birds in which the consummatory copulatory behavior is disrupted by treatment with the antiestrogen tamoxifen lose the anticipatory response. These results demonstrate that appetitive sexual behavior is, like copulation, activated by T and by estrogens. This suggests that intracerebral aromatization of T also plays a critical role in the activation of this behavior. [less ▲]

Detailed reference viewed: 19 (1 ULg)
Full Text
Peer Reviewed
See detailMétapsychologie de l'adolescence
Stassart, Martine ULg

in Cahiers du CEP (Centre d'Etudes Pathoanalytiques) (1995), 5(2), 71-104

Before 1960 there was very few psychoanalytical litterature about adolescence. Since 50 years, there is plenty of articles on that subject. The author comments the most important psychoanalytical writers ... [more ▼]

Before 1960 there was very few psychoanalytical litterature about adolescence. Since 50 years, there is plenty of articles on that subject. The author comments the most important psychoanalytical writers who brought a new and useful thought thereabout. [less ▲]

Detailed reference viewed: 181 (24 ULg)
Peer Reviewed
See detailPharma-clinics. Comment j'explore... une asthenie chronique
Moutschen, Michel ULg

in Revue Médicale de Liège (1995), 50(6), 268-9

Detailed reference viewed: 6 (1 ULg)
Peer Reviewed
See detailClosantel Intoxication in a Dog
Mc Entee, Kathleen ULg; Grauwels, Magda ULg; Clercx, Cécile ULg et al

in Veterinary and Human Toxicology (1995), 37(3), 234-6

A case of overdosage with closantel, a salicynalide derivative, in a dog is described. The dog received 6 times the recommended dosage. Closantel induced optic neuritis, retinal degeneration, partial ... [more ▼]

A case of overdosage with closantel, a salicynalide derivative, in a dog is described. The dog received 6 times the recommended dosage. Closantel induced optic neuritis, retinal degeneration, partial deafness, hepatotoxicosis and myopathy. Only the blindness was irreversible. The therapy included albumin administration to reduce the acute toxicity of closantel. [less ▲]

Detailed reference viewed: 78 (0 ULg)
Full Text
Peer Reviewed
See detailSexual Differentiation of Brain and Behavior in Quail and Zebra Finches: Studies with a New Aromatase Inhibitor, R76713
Foidart, Agnès ULg; Balthazart, Jacques ULg

in Journal of Steroid Biochemistry & Molecular Biology (1995), 53(1-6), 267-75

In many species of vertebrates, major sex differences affect reproductive behavior and endocrinology. Most of these differences do not result from a direct genomic action but develop following early ... [more ▼]

In many species of vertebrates, major sex differences affect reproductive behavior and endocrinology. Most of these differences do not result from a direct genomic action but develop following early exposure to a sexually differentiated endocrine milieu. In rodents, the female reproductive phenotype mostly develops in the absence of early steroid influence and male differentiation is imposed by the early action of testosterone, acting at least in part through its central conversion into estrogens or aromatization. This pattern of differentiation does not seem to be applicable to avian species. In Japanese quail (Coturnix japonica), injection of estrogens into male embryos causes a permanent loss of the capacity to display male-type copulatory behavior when exposed to testosterone in adulthood. Based on this experimental result, it was proposed that the male reproductive phenotype is "neutral" in birds (i.e. develops in the absence of endocrine influence) and that endogenous estradiol secreted by the ovary of the female embryo is responsible for the physiological demasculinization of females. This model could be recently confirmed. Females indeed display a higher level of circulating estrogens that males during the second part of their embyronic life. In addition, treatment of female embryos with the potent aromatase inhibitor, R76713 or racemic vorozole which suppresses the endogenous secretion of estrogens maintains in females the capacity to display the full range of male copulatory behaviors. The brain mechanisms that control this sexually differentiated behavior have not been identified so far but recent data suggest that they should primarily concern a sub-population of aromatase-immunoreactive neurons located in the lateral parts of the sexually dimorphic preoptic nucleus. The zebra finch (Taeniopygia guttata) exhibits a more complex, still partly unexplained, differentiation pattern. In this species, early treatment with exogenous estrogens produces a masculinization of singing behavior in females and a demasculinization of copulatory behavior in males.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

Detailed reference viewed: 24 (2 ULg)
Peer Reviewed
See detailCopper whisker growth from inside sulfur-doped YBa2Cu307-X pellets
Cloots, Rudi ULg; Krekels, T.; Warin, R. et al

in Journal of Solid State Chemistry (1995), 117(1), 151-156

We report on the growth of Cu whiskers (10 mu m in linear transverse size) at the surface of a YBCO pellet, in a sulfur-rich atmosphere at a high synthesis temperature. Growth arises from inside the ... [more ▼]

We report on the growth of Cu whiskers (10 mu m in linear transverse size) at the surface of a YBCO pellet, in a sulfur-rich atmosphere at a high synthesis temperature. Growth arises from inside the pellet since there is no Cu in the surrounding atmosphere. We present the experimental conditions and electron microscopic observations. We briefly propose a mechanism based on chemical considerations, in particular, a Cu reductive nucleation of the CuS phase at the surface of YBCO. Natural phenomena, laboratory findings, and computer simulation work (based on an Eden model) support this interpretation. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailCalcium et squelette: base physiologique d'une prévention
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1995), 50(6), 244-8

Detailed reference viewed: 7 (4 ULg)
Full Text
Peer Reviewed
See detailMicrodynamics of reverse micelles of ω- and α,ω-metal sulfonato polystyrene in toluene
Vanhoorne, Pierre ULg; Grandjean, Jean ULg; Jérôme, Robert ULg

in Macromolecules (1995), 28(10), 3553-3561

Reverse micelles of omega- and alpha,omega-metal sulfonato polystyrenes in toluene have been investigated by Li-6, Li-7, and pulsed field gradient NMR. Micelles are found to be of a narrow size ... [more ▼]

Reverse micelles of omega- and alpha,omega-metal sulfonato polystyrenes in toluene have been investigated by Li-6, Li-7, and pulsed field gradient NMR. Micelles are found to be of a narrow size distribution and to consist of roughly spherical ionic cores shielded from the solvent by a polystyrene shell. The nature of the ion pair is found to influence significantly the micellar size. The correlation time characteristic of lithium relaxation is faster than the reorientational correlation time of the aggregates, which means that lithium relaxation essentially takes place within the ionic cores. The effective relaxation mechanism is consistent with a fast exchange of lithium ions between different coordination sites within the aggregates. In concentrated solutions, the equilibrium between aggregated polymer chains and unassociated chains is essentially shifted toward the aggregated species. This tendency is reversed upon dilution. Below a critical micellar concentration of ca. 0.01 g/dL, only ''free'' chains persist in solution. Temperature has no significant effect on the position of the aggregation equilibrium. The aggregates are dissociated by the addition of a polar cosolvent, such as methanol, which solvates the ion pairs. The MeOH/Li+ molar ratio must, however, be higher than 100 to perturb significantly the ion pair aggregation. Up to a MeOH/Li+ ratio of 10 000, part of the chains remain aggregated, and the lithium spin-lattice relaxation is dominated by the aggregates. Above a MeOH/Li+ ratio of 10 000, the aggregates are almost completely disrupted. Self-diffusion coefficients of the difunctional chains are not dramatically smaller compared to the monofunctional counterparts, even when solutions of difunctional compounds form a gel. This behavior might be explained by the percolation model applied to the aggregation process, with the pulsed field NMR experiment probing only the selfdiffusion of the clusters in the sol phase of the gel. [less ▲]

Detailed reference viewed: 23 (2 ULg)
Full Text
Peer Reviewed
See detailHeavy elements in halo stars: the r/s-process controversy.
Magain, Pierre ULg

in Astronomy and Astrophysics (1995), 297

It has been suggested by Truran (1981) that rapid neutron captures (the r-process) dominate the production of heavy elements in very metal-poor stars. Several spectroscopic works analyzing that hypothesis ... [more ▼]

It has been suggested by Truran (1981) that rapid neutron captures (the r-process) dominate the production of heavy elements in very metal-poor stars. Several spectroscopic works analyzing that hypothesis are reviewed and rediscussed and it is shown that there is, in fact, no secure observational evidence in support of Truran's suggestion. A method to determine the odd-to-even isotopic ratio of barium, and thus to estimate the relative contributions of the r and s-processes, is presented. It takes advantage of the hyperfine structure affecting the spectral lines of the odd isotopes to distinguish them from the even isotopes. This method, applied to the classical metal-poor subgiant HD 140283, shows that the barium isotopic ratio in that star is in agreement with a pure s-process production, and excludes any significant enhancement of the r-process contribution, in disagreement with previous works based on elemental abundances. [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailTemps et Don. Le Présent des médias
Durand, Pascal ULg

in Recherches en Communication (1995), 3

Detailed reference viewed: 22 (7 ULg)
Full Text
Peer Reviewed
See detailElectrophysiologic evaluation of the phrenic nerve-diaphragm pathway in an intact conscious calf model
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in American Journal of Veterinary Research (1995), 56(5), 545-554

Owing to technical and ethical limitations, a substantial part of the knowledge about the pathophysiologic mechanism of the human diaphragm has been obtained from studies in which phrenic nerve activation ... [more ▼]

Owing to technical and ethical limitations, a substantial part of the knowledge about the pathophysiologic mechanism of the human diaphragm has been obtained from studies in which phrenic nerve activation was usually carried out by direct surgical exposure of the nerves in the neck of deeply anesthetized, mechanically ventilated animals. Novel information has been gleaned from such studies, but the restrictive conditions under which it was collected preclude reliable extrapolation. We, therefore, addressed the question of whether accurate electrophysiologic evaluation of the phrenic nerve-diaphragm pathway can be performed in intact, nonanesthetized calves. Transjugular phrenic activation was well tolerated, safe, specific, and able to achieve constant symmetric and supramaximal phrenic stimulations during prolonged periods. Eighteen noninvasive cutaneous and esophageal reception circuits were tested for their ability to record the diaphragmatic evoked potential. In addition, they were compared for specificity and reproducibility of the recorded potentials during prolonged periods of tidal or stimulated respiration. The best diaphragmatic potential was recorded from surface electrodes attached to the skin of the ninth and tenth intercostal spaces, using a xyphoidian reference. We describe a method that allows easy, longterm, and reliable electrophysiologic evaluation of the phrenic nerve-diaphragm pathway in intact, conscious calves. It is hoped that such a model will produce relevant novel information regarding pathophysiology of the diaphragm. [less ▲]

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailA Double-Blind, Placebo-Controlled, Dose-Finding Trial of Intermittent Nasal Salmon Calcitonin for Prevention of Postmenopausal Lumbar Spine Bone Loss
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Lecart, M. P. et al

in American Journal of Medicine (1995), 98(5), 452-8

PURPOSE: Nasal administration of salmon calcitonin (SCT) has been suggested for preventing trabecular bone loss during the first years following the menopause, but no conclusive evidence has appeared ... [more ▼]

PURPOSE: Nasal administration of salmon calcitonin (SCT) has been suggested for preventing trabecular bone loss during the first years following the menopause, but no conclusive evidence has appeared about the minimal effective dose. Since nasal calcitonin is highly expensive, it makes sense to define this dose. PATIENTS AND METHODS: We performed a double-blind, placebo-controlled, randomized, single-center study with a 3-arm parallel-group design. The subjects were 251 healthy women who had experienced natural menopause within the past 6 to 72 months and were not affected by any diseases or treatments that interfere with calcium metabolism. They were randomly allocated in groups of 6 to receive intranasal SCT 50 IU (n = 84), SCT 200 IU (n = 84), or placebo (n = 83). All treatments were given on 5 consecutive days per week. Statistical analysis was based on two populations: intention-to-treat (IT) and valid completers (VC). The main assessments performed were bone mineral density of the lumbar spine (LSBMD) and biochemical parameters reflecting bone turnover (serum alkaline phosphatase, urinary calcium/creatinine, and hydroxyproline/creatinine ratios). RESULTS: Changes over the treatment period were comparable in the IT and VC populations. In the group receiving the placebo, LSBMD decreased from baseline to end point by a mean of 6.28% (95% confidence interval [CI] -7.69 to -4.89) in the IT population and 6.98% (95% CI -8.86 to -5.11) in the VC population (P = 0.0001, end LSBMD versus baseline LSBMD). LSBMD increased slightly with the 50-IU/d dose of SCT, by 0.82% (95% CI -0.26 to 1.89) in the IT population, and 0.51% (95% CI -0.69 to 1.72) in the VC (P = NS, versus baseline). Subjects who received SCT 200 IU/d experienced significant increases of 2.03% (95% CI 0.92 to 3.15) in the IT population and 2.26% (95% CI 1.01 to 3.51) in the VC (both P = 0.001). The difference between the evolution of the combined groups receiving nasal SCT and the group treated with the placebo was highly significant (P = 0.0001). No significant changes were recorded in biochemical parameters reflecting bone turnover. CONCLUSIONS: SCT 50 IU/d administered nasally and intermittently appears to prevent lumbar bone loss in nonobese early postmenopausal women. [less ▲]

Detailed reference viewed: 9 (2 ULg)
See detailLes plaisirs romanesques. Le roman au XVIIIe siècle en France et en Angleterre
Durand, Pascal ULg

in Loisirs-Magazine, revue sur cassette de la Ligue Braille (1995), (88),

Detailed reference viewed: 12 (2 ULg)
Peer Reviewed
See detailAn interactive activation model of face naming
Brédart, Serge ULg; Valentine, T.; Calder, A. et al

in Quarterly Journal of Experimental Psychology (1995), 48A(2), 466-486

Burton and Bruce's (1992) model of face naming predicts a "fan effect", in which naming of famous people about whom many descriptive properties are known should be slower than naming of celebrities about ... [more ▼]

Burton and Bruce's (1992) model of face naming predicts a "fan effect", in which naming of famous people about whom many descriptive properties are known should be slower than naming of celebrities about whom few properties are known. An experiment is reported that showed that, contrary to this prediction, knowledge of many descriptive properties facilitated face-naming latency. An alternative architecture for an interactive activation model is proposed in which descriptive properties are represented in separate pools of units for each domain of information and in which names are represented by a separate pool of lexical output units. Computer simulations showed that this model could simulate the previously available empirical data as effectively as Burton and Bruce's (1992) original model. However, the proposed model could also simulate the effect of the number of known descriptive properties upon face-naming latency observed in the experiment reported. The new architecture also has the advantage of being more compatible with current models of speech production, and it allows preserved access to unique semantic properties in the context of impaired face naming as reported in the neuropsychological literature. [less ▲]

Detailed reference viewed: 34 (4 ULg)
Full Text
Peer Reviewed
See detailEXAFS study of halato-telechelic polymers and-capped with group IVb metal carboxylates at room and low temperature
Vlaic, G.; Navarra, G.; Regnard, J. R. et al

in Journal of Physics II France (1995), 5(5), 665-675

The EXAFS analysis at 300, 70 and 5 K has shown that the thermal disorder is very low in a carboxylato telechelic polybutadiene neutralized with an increasing excess of Zr isopropoxide. Two types of Zr-O ... [more ▼]

The EXAFS analysis at 300, 70 and 5 K has shown that the thermal disorder is very low in a carboxylato telechelic polybutadiene neutralized with an increasing excess of Zr isopropoxide. Two types of Zr-O bonds in the first shell account for the experimental data. The Zr-O distances and number of oxygen neighbours in the two subshells are found to be independent of temperature in the investigated range. The proportion of Zr in the samples has no effect on the total number of oxygen atoms around Zr, in contrast to their relative distribution in the two subshells. The number of Zr atoms increases in the second shell with the total amount of this metal. Upon increasing degree of neutralization from 200 to 600%, the static disorder increases together with a strong reduction of the dynamic part of the Debye-Waller (DW) factor. At a high degree of neutralization (> 400%), the DW factor for the Zr-Zr bond is largely independent of temperature. These observations agree with formation of Zr polynuclear microdomains, the size and rigidity of which increase with the Zr content, in good agreement with the profound changes previously reported in the viscoelastic properties of these materials. [less ▲]

Detailed reference viewed: 33 (3 ULg)
Peer Reviewed
See detailSpontaneous and Induced Apoptosis after Whole Body Radiation Exposure: Experimental Approaches. Observations in Radio-Induced Thymic Lymphomagenesis
Humblet, Chantal ULg; Deman, J.; Franzen, Rachelle ULg et al

in Stem Cells (1995), 13(Suppl 1), 129-35

Radio-induced thymic lymphomagenesis is associated with alterations in the balance between thymocyte subsets and cytokinetic perturbations. The objectives of this work were to investigate whether these ... [more ▼]

Radio-induced thymic lymphomagenesis is associated with alterations in the balance between thymocyte subsets and cytokinetic perturbations. The objectives of this work were to investigate whether these alterations are associated with alterations in the basic levels of thymocyte apoptosis. For this purpose, we tested DNA fragmentation by gel electrophoresis, analyzed DNA content by propidium iodide staining of ethanol fixed cells and looked for DNA strand breaks on tissue sections by in situ end labeling. We described an increase of the levels of apoptosis in cultured thymocytes during the preleukemic period, while the basic levels of apoptosis observed in situ are similar in normal and in preleukemic thymuses. We propose that after leukemogenic irradiations, there is an increase of cells wherein the cell suicide program is activated but that environmental thymic factors rescue them from apoptosis. Preleukemic cells could belong to this abnormally surviving population of cells "programmed to die," wherein additional genomic abnormalities would lead to fully neoplastic transformation. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailExploration du testicule cryptorchide non palpe
Waltregny, David ULg; de Leval, Jean ULg

in Acta Urologica Belgica (1995), 63(2), 69-76

Cryptorchidism affects approximately 1 in 150 boys. Non-palpable testes represent nearly 20% of all cases. If present, they are situated between the inferior renal pole and the external inguinal ring ... [more ▼]

Cryptorchidism affects approximately 1 in 150 boys. Non-palpable testes represent nearly 20% of all cases. If present, they are situated between the inferior renal pole and the external inguinal ring. Often at surgical exploration, however, a "nubbin" of testicular tissue is found at the end of blind ending spermatic vessels without demonstration of a recognizable testis; this finding is referred to as an absent testis. In other patients, no vascular or ductular (epididymis-vas deferens) or even testicular structure can be observed. This situation defines true testicular agenesis. Non-palpable testes have an increased risk of malignant transformation, infertility, associated inguinal hernia and congenital ductular abnormalities. Surgical treatment is often more complex and unsuccessful. Many imaging diagnostic methods to investigate patients with non-palpable testes (pneumoperitoneography, angiography, ultrasonography, CT scan and RMN) have been used so far but none of these has been uniformly accepted as the ideal investigative technique because they are unreliable and/or they involve a fair risk. Since Cortesi and associates first described in 1976 a case of abdominal testes identified by laparoscopy, this technique has gained increased acceptance by pediatric urologists and surgeons. Today, celioscopy plays a central role in the exploration of non-palpable cryptorchid testes. The authors try to establish an algorithm methodology for investigating non-palpable testes under the light of recently reported anatomical, pathological and surgical data. [less ▲]

Detailed reference viewed: 87 (3 ULg)
Peer Reviewed
See detailArbres, ordres maximaux et formes quadratiques entières
Pays, Isabelle ULg

in London Mathematical Society, Lecture Notes Series 215 (1995)

Detailed reference viewed: 36 (6 ULg)
Full Text
Peer Reviewed
See detailCritical Re-Examination of the Distribution of Aromatase-Immunoreactive Cells in the Quail Forebrain Using Antibodies Raised against Human Placental Aromatase and against the Recombinant Quail, Mouse or Human Enzyme
Foidart, Agnès ULg; Reid, J.; Absil, Philippe ULg et al

in Journal of Chemical Neuroanatomy (1995), 8(4), 267-82

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid ... [more ▼]

Mouse and quail aromatase cDNAs were isolated from libraries of mouse ovary and quail brain by using a human aromatase cDNA fragment (hA-24) as a probe. These three cDNAs were inserted into plasmid vectors and expressed in Escherichia coli. Antisera against these purified recombinant proteins were raised in rabbit and purified by ammonium sulfate fractionation and affinity chromatography. The three antibodies directed against recombinant human, mouse and quail proteins were used to visualize aromatase-immunoreactive cells in the quail brain. They were compared with the antibody raised against human placental aromatase used in previous experiments and with another antibody recently developed by similar methods. The signal obtained with all antibodies was completely abolished by preadsorption with the homologous recombinant antigens and the signal produced by the two antibodies raised against placental aromatase was similarly abolished by a preadsorption with recombinant quail aromatase. The antibodies raised against recombinant proteins identified the major groups of aromatase cells previously described in the quail brain. The antibodies directed against the mouse and quail antigen identified more positive cells and stained them more densely than the antibodies raised against human recombinant antigen or purified placental aromatase. The new cell groups identified by the antibody raised against quail recombinant aromatase were located in an area ventral to the fasciculus prosencephali lateralis, the nucleus accumbens, the paleostriatum ventrale, the nucleus taeniae, the area around the nucleus ovoidalis, the caudal tuber and the mesencephalic central gray. A critical re-examination of the distribution and nomenclature of the aromatase-positive cells is proposed based on these new findings. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailIsolement et caractérisation partielle d'une glycoprotéine associée à la gestation chez la brebis
Zoli, A. P.; Beckers, Jean-François ULg; Ectors, Francis ULg

in Annales de Médecine Vétérinaire (1995), 139

Detailed reference viewed: 21 (0 ULg)
Peer Reviewed
See detailComment je traite... un patient avec une insuffisance cardiaque sévère ou aggravée
Pierard, Luc ULg

in Revue Médicale de Liège (1995), 50(5), 197-8

Detailed reference viewed: 1 (0 ULg)
Full Text
Peer Reviewed
See detailShear thickening of halato-telechelic polymers in apolar solvents
Maus, Christian; Fayt, Roger; Jérôme, Robert ULg et al

in Polymer (1995), 36(10), 2083-2088

Short-length polymers selectively end-capped with a metal carboxylato group at both ends, i.e, metal carboxylato-telechelic polymers, exhibit an unusual shear-thickening behaviour in apolar solvents ... [more ▼]

Short-length polymers selectively end-capped with a metal carboxylato group at both ends, i.e, metal carboxylato-telechelic polymers, exhibit an unusual shear-thickening behaviour in apolar solvents, depending on the main experimental parameters that control the ion-pair association, such as metal cation, concentration and temperature. In contrast to the non-ionic precursors, metal carboxylato-telechelics are indeed responsible for a marked increase in the solution viscosity in a range of shear rates between 0.1 and 1000 s(-1). The shear-rate dependence of the solution viscosity has been analysed in a close relationship to metal counterion, polymer concentration, temperature and addition of polar compounds to the apolar solvent. As a rule, the dilatant behaviour depends strongly on the formation of polymer aggregates in relation to the mutual interactions of the ion pairs. A consensus is now emerging on the origin of the shear-thickening effect, which should be found in inter-aggregate associations rather than in a transition from intramolecular to intermolecular associations of the individual chains. [less ▲]

Detailed reference viewed: 40 (1 ULg)
Peer Reviewed
See detailIntérêt de l'étude de l'expectoration induite en pathologie pulmonaire
Kayembe, J. M.; Louis, Renaud ULg; Bury, Thierry ULg et al

in Revue Médicale de Liège (1995), 50(5), 209-12

Detailed reference viewed: 31 (1 ULg)
Peer Reviewed
See detailActivité sportive et susceptibilité à l'infection
Bury, Thierry ULg

in Revue Médicale de Liège (1995), 50(5), 222-5

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailImmunogold Labelling of Fatty Acyl Chains
Compère, Philippe ULg; Maneta-Peyret, Lilly; Goffinet, Gerhard ULg et al

in Journal of Immunological Methods (1995), 181(2), 201-9

For the first time, antibodies against a hydrophobic hapten have been used for immunogold labelling of a lipid antigen (BSA-C18:1 conjugate) coated on polystyrene. The labelling was visualised either ... [more ▼]

For the first time, antibodies against a hydrophobic hapten have been used for immunogold labelling of a lipid antigen (BSA-C18:1 conjugate) coated on polystyrene. The labelling was visualised either directly in transmission electron microscopy or in light microscopy after silver enhancement. Good recognition of the fatty acyl chain was obtained even after treatment of the antigen coat with various cross-linking fixatives used for electron microscopy, i.e. formaldehyde, glutaraldehyde and osmium tetroxide. [less ▲]

Detailed reference viewed: 11 (3 ULg)
Full Text
Peer Reviewed
See detailMutational analysis of varicella-zoster virus major immediate-early protein IE62
Baudoux, Laurence; Defechereux, Patricia; Schoonbroodt, Sonia et al

in Nucleic Acids Research (1995), 23(8), 1341-1349

The varicella-zoster virus (VZV) open reading frame 62 encodes an immediate-early protein (IE62) that transactivates expression of various VZV promoters and autoregulates its own expression in transient ... [more ▼]

The varicella-zoster virus (VZV) open reading frame 62 encodes an immediate-early protein (IE62) that transactivates expression of various VZV promoters and autoregulates its own expression in transient expression assays. In Vero cells, IE62 was shown to transactivate the expression of all putative immediate-early (IE) and early (E) genes of VZV with an up-regulating effect at low intracellular concentrations. To define the functional domains involved in the regulatory properties of IE62, a large number of in-frame insertions and deletions were introduced into a plasmid-borne copy of the gene encoding IE62. Studies of the regulatory activities of the resultant mutant polypeptides in transient expression assays allowed to delineate protein regions important for repression of its own promoter and for transactivation of a VZV putative immediate-early gene (ORF61) promoter and an early gene (ORF29) promoter. This mutational analysis resulted in the identification of a new functional domain situated at the border between regions 4 and 5 which plays a crucial role in the IE62 regulatory functions. This domain turned out to be very well conserved amongst homologous alphaherpesvirus regulatory proteins and appeared to be rich in bulky hydrophobic and proline residues, similar to the proline-rich region of the CAAT box binding protein CTF-1. By immunofluorescence, a nuclear localization signal has been mapped in region 3. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailGlobal compartmental analysis of the fluorescence decay surface of the halato telechelic polymer (N,N-dimethyl-N-[3-(1-pyrenyl)propyl]ammonio)-trifluoro-methanesulfonate-end-capped poly(tetrahydrofuran
Hermans, Bart; De Schryver, Frans C; Van Stam, Jan et al

in Macromolecules (1995), 28(9), 3380-3386

The kinetic behavior of the halato telechelic polymer (N,N-dimethyl-N-[3-(1-pyrenyl)propyl]-ammonio)trifluoromethanesulfonate-end-capped poly(tetrahydrofuran) (POLYPROBE) in tetrahydrofuran is ... [more ▼]

The kinetic behavior of the halato telechelic polymer (N,N-dimethyl-N-[3-(1-pyrenyl)propyl]-ammonio)trifluoromethanesulfonate-end-capped poly(tetrahydrofuran) (POLYPROBE) in tetrahydrofuran is investigated by global compartmental analysis of the fluorescence decay surface. At low POLYPROBE concentrations the emission decays monoexponentially. When an analogous end-capped halato telechelic polymer without the pyrene chromophore ((N,N,N-triethylammonio)trifluoromethanesulfonate-end-capped poly(tetrahydrofuran), POLYSALT) is added to solutions containing a low POLYPROBE concentration, the emission can be fitted by a biexponential decay function. From these observations it is concluded that the second excited-state species in the POLYPROBE-POLYSALT system is POLYPROBE involved in ion aggregation due to dipole-dipole or ion-dipole interaction. At higher POLYPROBE concentrations, without added POLYSALT, a triexponential decay function is needed to describe the emission. The third excited-state species is POLYPROBE excimer, which can be formed via two pathways: either intermolecularly when a locally excited POLYPROBE encounters a ground-state POLYPROBE or intramolecularly when an aggregate of two POLYPROBE molecules rearranges. From the global compartmental analysis in which the value of one of the rate constants is scanned, it is found that the bimolecular processes are slowed down by the presence of the polymer chain, while intramolecular rearrangements are not affected. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailGalectin-1 Modulates Human Melanoma Cell Adhesion to Laminin
van den Brule, F. A.; Buicu, C.; Baldet, M. et al

in Biochemical and Biophysical Research Communications (1995), 209(2), 760-7

Galectins constitute a gene family of beta-galactoside-specific lectins that show high homology in their carbohydrate-binding site. They have been postulated to be involved in many biological events, but ... [more ▼]

Galectins constitute a gene family of beta-galactoside-specific lectins that show high homology in their carbohydrate-binding site. They have been postulated to be involved in many biological events, but their specific functions are not yet well defined. Galectin-1 is a laminin binding protein that recognizes poly-N-acetyllactosamine chains on this major basement membrane glycoprotein. In this study, we analyzed the possibility that galectin-1 could modulate interactions between human melanoma cells and laminin. We demonstrated that A375 and A2058 cell lines express galectin-1 both intracellularly and on the cell surface. In an in vitro assay, recombinant galectin-1 increased melanoma cell attachment to laminin in a dose-dependent manner. This effect was abolished by lactose. Anti-galectin-1 inhibited adhesion of melanoma cells to laminin in a dose-dependent fashion. However, neither galectin-1 nor anti-galectin-1 antibody affected melanoma cell spreading on laminin in vitro. These data indicate that galectin-1 might participate in melanoma cell adhesion to laminin and therefore could be a modulator of invasion and metastasis. [less ▲]

Detailed reference viewed: 17 (2 ULg)