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See detailQuelques réflexions de nature didactique concernant l'introduction de la courbure en relativité générale
De Rop, Yves ULg

in Revue des Questions Scientifiques (2001), 172(4), 335-346

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See detailChanges in lipoxygenase and hydroperoxide decomposition activity in tissues cultures of soybean
Fauconnier, Marie-Laure ULg; Mouttalib, A.; Billo, D. et al

in Journal of Plant Physiology (2001), 158(7), 953-955

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia ... [more ▼]

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia. Exogenously applied hormones resulted in important changes in both Lox and HPO decomposition activity. Lox activity was higher in extracts from tissues cultured in medium supplemented with NAA or 2,4-D, while a lowest activity was recorded in extracts from cultures treated with BA. 13-HPOD was cleaved by all tested extracts, while 13-HPOT and 9-HPOD were cleaved exclusively by extracts from tissues cultured in the presence of BA. [less ▲]

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See detailCore-shell-corona micelles with a responsive shell
Gohy, Jean-François; Willet, Nicolas ULg; Varshney, Sunil et al

in Angewandte Chemie (International ed. in English) (2001), 40(17), 3214-3216

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See detailFour years of induction/synchronization of estrus in dairy goats: effect on the evolution of eCG binding rate in relation with the parameters of reproduction
Drion, Pierre ULg; Furtoss, V.; Baril, G. et al

in Reproduction Nutrition Development (2001), 41(5), 401-412

Ninety-eight Alpine goats of two herds were followed over 4 years in a program of annual artificial insemination after estrus induction/synchronization, including progestagen administration (vaginal ... [more ▼]

Ninety-eight Alpine goats of two herds were followed over 4 years in a program of annual artificial insemination after estrus induction/synchronization, including progestagen administration (vaginal sponge) followed by prostaglandin analog and equine chorionic gonadotrophin (eCG) 48 h before sponge removal. Goats were sampled every 4 hours from the 16th to the 56th following sponge removal, for determination of LH surge and tested for estrus by the presence of a buck. Seven days after AI, endoscopic examination of the ovaries was performed to determine the number of corpus lutea. Pregnancy diagnosis was performed at day 21-22 post AI by determination of plasma progesterone and at day 40-45 by ultrasonography. Parturition, number and sex of kids were recorded. All the goats were sampled before and after each treatment, for anti-eCG antibodies screening. Statistical analysis of the results clearly established a significant effect of the treatments on anti-eCG antibodies. Time of estrus and LH surge were significantly different between herd. The antibodies significantly delayed the time of coming out of estrus as well as the time of LH surge. Two antagonistic effects were evidenced: first, the delayed of time of estrus and time of LH surge in relation with the immune reaction to eCG; secondly, the ahead of time of estrus and time of LH surge during the years of treatment, identical to both herd. The antibodies negatively influenced the percentage of ovulating females as well as kidding rate. Finally, no effect of antibodies on prolificacy was found. [less ▲]

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See detailSpécificités de la fonction cardiorespiratoire de l'âne (Equus asinus)
Delvaux, Véronique ULg; Kirschvink, Nathalie; Amory, Hélène ULg et al

in Pratique Vétérinaire Equine (2001), 33(129), 21-28

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For ... [more ▼]

A group of 22 donkeys underwent a serres of non-invasive cardiorespiratory tests in order to establish the reference standards for this species and compare the results with those for horses. For particular tests (haematology, measurement of arterial blond gases, electrocardiogram with phonocardiogram and thoracic radiographs, cardias echography), no major differences were found. However, the mechanical ventilation parameters differed from those for horses and moere similar to Chose for food-producing animais (carde): a higher resistance, a lower compliance and a higher maximum pleural pressure variation moere found. The "respiratory strategy" adopted by certain donkeys is different from that of horses: there are two to three phases of inspiration with a nil airflow between each phase. Expiration is the same as for horses. The conformation of the pharynx and larynx is slightly different to that of horses making it more difficult to pass an endoscope through this area. The lower respiratory tract is sensitive and it is necessary to apply a local anaesthetic (xylocaine) for this examination. The différential leukocyte count from tracheal lavage includes a number of epithelial cells, and a higher percentage of eosinophils and neutrophile for donkeys compared to horses. These similarities and différences between donkeys and horses should be taken into account when performing ancillary tests [less ▲]

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See detailSynthesis of large pore disordered MSU-type mesoporous silicas through the assembly of C16(EO)10 surfactant and TMOS silica source: Effect of the hydrothermal treatment and thermal stability of materials
Blin, J. L.; Léonard, Alexandre ULg; Su, B. L.

in Journal of Physical Chemistry B (2001), 105(26), 6070-6079

Decaoxyethylene cetyl ether [C 16(EO) 10] has been employed as templating agent for large pore disordered MSU-type mesoporous silicas synthesis. The effect of the hydrothermal treatment (heating time and ... [more ▼]

Decaoxyethylene cetyl ether [C 16(EO) 10] has been employed as templating agent for large pore disordered MSU-type mesoporous silicas synthesis. The effect of the hydrothermal treatment (heating time and temperature) on the textural properties, in particular, pore diameter of materials has been investigated. The obtained materials have been characterized by different techniques such as X-ray diffraction, scanning and transmission electron microscopy and nitrogen adsorption-desorption analysis. The thermal stability of the compounds is also evaluated. Our results show that the pore diameter depends strongly on the heating time and temperature. This is the result of a competition between the stretching of the surfactant chains, which can lead to the breakdown of the walls separating adjacent pores, and the reorganization of micelles with heating time and temperature. At higher temperature or for longer durations, a more extended surfactant molecular conformation can be obtained, which leads to materials with larger pore sizes. A reorganization of the micellar solution during the hydrothermal treatment in autoclave can also simultaneously occur to give materials with smaller pore diameter. It is found that compounds prepared with the nonionic surfactant exhibit an enhanced thermal stability compared to those synthesized with cetyltrimethylammonium bromide (CTMABr) as templating agent. This higher stability is related to the synthesis pathway and the structure of materials. [less ▲]

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See detailRt-Pcr-Elosa Tests On Pooled Sample Units For The Detection Of Virus Y In Potato Tubers
Chandelier, Anne; Dubois, Nathalie ULg; Baelen, Frédéric et al

in Journal of Virological Methods (2001), 91(2), 99-108

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See detailCharacterization of the human Fc gamma RIIB gene promoter: human zinc-finger proteins (ZNF140 and ZNF91) that bind to different regions function as transcription repressors
Nishimura, Tadahiro; Narita, Tadashi; Miyazaki, Emi et al

in International Immunology (2001), 13(8), 1075-84

Expression of the human low-affinity Fc receptors for IgG (human Fc gamma RII) is differentially regulated. We report here the characterization of the promoter structure of the human Fc gamma RIIB gene ... [more ▼]

Expression of the human low-affinity Fc receptors for IgG (human Fc gamma RII) is differentially regulated. We report here the characterization of the promoter structure of the human Fc gamma RIIB gene and the isolation of the promoter region-binding proteins by a yeast one-hybrid assay. The minimal 154-bp region upstream from the transcription start site of the human Fc gamma RIIB gene was shown to possess promoter activity in a variety of cells. An electrophoretic mobility shift assay indicated that multiple nuclear factors in cell extracts bind to the two regions [F2-3 (-110 to -93) and F4-3 (-47 to -31)] of the human Fc gamma RIIB gene promoter. Mutation analysis indicated that GGGAGGAGC (-105 to -97) and AATTTGTTTGCC (-47 to -36) sequences are responsible for binding to nuclear factors respectively. By using GGGAGGAGC and AATTTGTTTGCC as bait sequences, we cloned two zinc-finger proteins (ZNF140 and ZNF91) that bind to the F2-3 and F4-3 regions within the promoter of the human Fc gamma RIIB gene respectively. When the ZNF140 and ZNF91 were transfected with reporter plasmid, both showed repressor activity with additive effects. Thus, these results indicate that these cloned ZNF140 and ZNF91 proteins function as repressors for the human Fc gamma RIIB transcription. [less ▲]

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See detailFurther investigation of the supervisory attentional system in schizophrenia: Planning, inhibition, and rule abstraction
Marczewski, P.; Van der Linden, Martial ULg; Laroi, Frank ULg

in Cognitive Neuropsychiatry (2001), 6(3), 175-192

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational ... [more ▼]

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational level were compared. Three tasks (Tower of London, Hayling, and Brixton tests) were used to examine 3 executive processes (planning, inhibition, and rule detection). Schizophrenic patients performed significantly worse than normal controls on all 3 tasks. In addition, patients' performances on selected measures of the three tests were correlated, even when age and medication were partialled out. It is concluded that patients are impaired on all SAS functions. The possible role of a general impairment (processing speed or cognitive resources) is discussed [less ▲]

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See detailA psycho-endocrinological overview of transsexualism
Michel, Aude; Mormont, Christian ULg; Legros, Jean-Jacques ULg

in European Journal of Endocrinology (2001), 145(4), 365-376

The technical possibility of surgical sex change has opened up a debate concerning the legitimacy and utility of carrying out such an intervention at the request of the transsexual. Diagnostic ... [more ▼]

The technical possibility of surgical sex change has opened up a debate concerning the legitimacy and utility of carrying out such an intervention at the request of the transsexual. Diagnostic, psychological, medical and ethical arguments have been brought forth, both for and against. Nonetheless, anatomical transformation by surgical means has currently become a practice as the frequency of serious gender identity disorders is constantly progressing. After a brief introduction, the present paper will consider typological, aetiological and epidemiological aspects of transsexualism. Treatment of the sex change applicant is then defined and discussed in terms of psychological, psychiatric, endocrinological and surgical aspects. Finally, the question of post-operation follow-up will be examined. [less ▲]

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See detailTreatment of recurrent tendinitis by isokinetic eccentric exercises
Croisier, Jean-Louis ULg; Forthomme, Bénédicte ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2001), 9(2-3), 133-141

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities ... [more ▼]

The purpose of this study was to determine the effectiveness of eccentric training models in treating various types of tendinitis and evaluate protection from re-injury when returning to causal activities, Isokinetic eccentric training was administered to 34 patients with chronic tendinitis (9 Achilles, 10 patellar and 15 epicondyllar) with a long duration of symptoms and failure of conventional treatment. Following training which consisted of 20 to 30 sessions of progressive increase of load and speed parameters, a significant reduction of pain indicated by the visual analog scale (average initial value > 6.5, final score less than or equal to 2.5). Seventy four percent of the patients were completely relieved or presented marked decrease in symptoms when returning to sport and occupational activities. and only 12% reported no change in their functional state. At the end of treatment. isokinetic assessment revealed no significant concentric or eccentric peak torque asymmetries between involved and non-involved sides. In comparison with pretreatment ultrasound observations which showed systematic hypoechoic lesions and thickness, 14/34 patients recovered homogeneous tendon structure and normalization of the diameter and 15 presented improvement in echostructure. Our treatment model proposing isokinetic eccentric exercises presents a very satisfactory short-term effect on three different localizations of chronic tendinitis. [less ▲]

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See detailEnhanced survival of lung granulocytes in an animal model of asthma: evidence for a role of GM-CSF activated STAT5 signalling pathway
Turlej, Renata K; Fievez, Laurence ULg; Sandersen, Charlotte ULg et al

in Thorax (2001), 56(9), 696-702

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we ... [more ▼]

As granulocyte/macrophage colony stimulating factor (GM-CSF) mediated delay of granulocyte apoptosis contributes to the accumulation of inflammatory cells at the site of inflammation in many diseases, we sought to determine whether asthma is also associated with a GM-CSF dependent increase in lung granulocyte survival. Moreover, because GM-CSF mediates its effects through activation of signal transducer and activator of transcription 5 (STAT5), we also investigated the potential role of STAT5 in allergic inflammation. METHODS: Blood granulocytes were recovered from six healthy and six heaves affected horses, a model of asthma. Lung granulocytes were obtained by bronchoalveolar lavage (BAL) from the same horses. Granulocytes were cultured in the presence or absence of anti-GM-CSF receptor antibodies for different times and apoptosis was determined using the Annexin-V/propidium iodide detection method. Nuclear protein extracts from cultured granulocytes were analysed for STAT5 binding activity by electrophoretic mobility shift assay. RESULTS: BAL fluid granulocytes from heaves affected horses demonstrated a significant delay in apoptosis compared with blood granulocytes from the same horses and blood and BAL fluid granulocytes from healthy horses. Conversely, the rate of apoptosis in blood granulocytes from healthy and heaves affected horses was comparable. The enhanced survival of BAL fluid granulocytes from affected horses was suppressed in the presence of antibodies directed against GM-CSF receptors. Increased levels of active STAT5 were found in BAL fluid granulocytes from heaves affected horses and were markedly reduced after treatment with anti-GM-CSF receptor antibodies. CONCLUSIONS: These data indicate that granulocyte survival is enhanced in the lung of heaves affected horses and suggest a role for a GM-CSF activated STAT5 pathway in delaying apoptosis of lung granulocytes in this model of asthma. [less ▲]

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See detailA simplified one-pot synthesis of 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine([18F]FHPG) and 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) for gene therapy.
Shiue, Grace G.; Shiue, Ching-Yann; Lee, Roland L. et al

in Nuclear Medicine & Biology (2001), 28(7), 875-83

9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG, 2) has been synthesized by nucleophilic substitution of N(2)-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-toluenesulfonylox y ... [more ▼]

9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG, 2) has been synthesized by nucleophilic substitution of N(2)-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-toluenesulfonylox y-2-propoxy]methyl]guanine (1) with potassium [18F]fluoride/Kryptofix 2.2.2 followed by deprotection with 1 N HCl and purification with different methods in variable yields. When both the nucleophilic substitution and deprotection were carried out at 90 degrees C and the product was purified by HPLC (method A), the yield of compound 2 was 5-10% and the synthesis time was 90 min from EOB. However, if both the nucleophilic substitution and deprotection were carried out at 120 degrees C and the product was purified by HPLC, the yield of compound 2 decreased to 2%. When compound 2 was synthesized at 90 degrees C and purified by Silica Sep-Pak (method B), the yield increased to 10-15% and the synthesis time was 60 min from EOB. Similarly, 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG, 4) was synthesized with method A and method B in 9% and 10-15% yield, respectively, in a synthesis time of 90 and 60 min, respectively, from EOB. Compound 2 was relatively unstable in acidic medium at 120 degrees C while compound 4 was stable under the same condition. Both compound 2 and compound 4 had low lipid/water partition coefficient (0.126 +/- 0.022, n=5 and 0.165 +/- 0.023, n=5, respectively). Although it contains non-radioactive ganciclovir ( approximately 5-30 microg) as a chemical by-product, compound 2 synthesized by method B has a similar uptake in 9L glioma cells as that synthesized by method A, and is a potential tracer for imaging herpes simplex virus thymidine kinase gene expression in tumors using PET. Similarly, compound 4 synthesized by method B contains approximately 10-25 microg of penciclovir as a chemical by-product. Thus, the simplified one pot synthesis (method B) is a useful method for synthesizing both compound 2 and compound 4 in good yield for routine clinical use, and the method is readily amenable for automation. [less ▲]

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See detailEst-il raisonnable de prescrire de l'hormone de croissance aux personnes âgées ?
Legros, Jean-Jacques ULg; Geenen, Vincent ULg; Delmotte, Philippe

in Revue Médicale de Liège (2001), 56

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See detailStudy of the water/poly(ethylene glycol) interface by IR-visible sum-frequency generation spectroscopy
Dreesen, Laurent ULg; Humbert, C.; Hollander, P. et al

in Chemical Physics Letters (2001), 333

We used infrared-visible sum-frequency generation spectroscopy to investigate the vibrational properties of the water/poly(ethylene glycol) interface in the 2800-3800 cm-1 spectral range. The vibrational ... [more ▼]

We used infrared-visible sum-frequency generation spectroscopy to investigate the vibrational properties of the water/poly(ethylene glycol) interface in the 2800-3800 cm-1 spectral range. The vibrational fingerprint of the interface differs significantly from the one associated with the aire/poly(ethylene glycol) interface. It is shown that the poly(ethylene glycol) molecular arrangement, originally relatively well-ordered, becomes disorganised in the presence of water. Moreover, a new OH band is identified demonstrating the strong interaction of water with the polymer. [less ▲]

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See detailExperimental Hafting Traces. Identification and Characteristics
Rots, Veerle ULg; Pirnay, Louis; Pirson, Philippe et al

in Notae Praehistoricae (2001), 21

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See detailLa réforme de la procédure fiscale : le point de vue de la Cour d’arbitrage
Orban, Lionel ULg

in Fiscalité 2001. Le point sur les réformes », Journée d’études du Mercredi 31 octobre 2001, organisée par le Service de droit fiscal de la Faculté de droit de l’Université de Liège (2001)

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See detailLes empreintes globales en prothèse fixée
Lamy, Marc ULg; Mainjot, Amélie ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (2001), 56(3), 168-80

The global impression technique allows to obtain in a single stage the impression of the abutment as well as their neighboring teeth. This technique often requires the placement of one or two retraction ... [more ▼]

The global impression technique allows to obtain in a single stage the impression of the abutment as well as their neighboring teeth. This technique often requires the placement of one or two retraction cords in the sulcus. The impression technique herein described is the double mix method. This method is based on the use of two elastomers with different viscosities, but from the same group thus allowing a simultaneous polymerization. [less ▲]

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See detailNumerical modelling of lateral-torsional buckling of steel I-beams under fire conditions - Comparison with Eurocode 3
Vila Real, Paulo M. M.; Franssen, Jean-Marc ULg

in Journal of Fire Protection Engineering (2001), 11(2), 112-128

A geometrically and materially non-linear finite element program, i.e., a general model, has been used to determine the lateral-torsional resistance of steel I-beams under fire conditions, according to ... [more ▼]

A geometrically and materially non-linear finite element program, i.e., a general model, has been used to determine the lateral-torsional resistance of steel I-beams under fire conditions, according to the same material properties of Eurocode 3, Part 1-2. Two yield strengths, one cross section, one type of load and four different time exposures to the ISO 834 standard fire have been considered. The numerical results have been compared to the results of the simple model presented in Eurocode 3, Part 1-2. When compared with the general model, this simple model leads to a safety level that depends on the slenderness of the beam, being unsafe for intermediate non-dimensional slenderness. A new proposal has been made for a simple model that ensures a conservative result when compared to the general model. [less ▲]

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See detailRecommandations for the registration of drugs used in the treatment of osteoarthritis : an update on biochemical markers
Vignon, E; Gamero, P; Delmas, P et al

in Osteoarthritis and Cartilage (2001), 9

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See detailImproved Quantification of Angiogenesis in the Rat Aortic Ring Assay
Blacher, Silvia ULg; Devy, L.; Burbridge, M. F. et al

in Angiogenesis (2001), 4(2), 133-42

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by ... [more ▼]

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by Nicosia bridges the gap between in vivo and in vitro models. The quantification of angiogenesis on this system must be applicable to characterise vascular networks of various states of complexity. We present here an improved computer-assisted image analysis which allows: (1) the determination of the aortic ring area and its factor shape; (2) the number of microvessels, the total number of branchings, the maximal microvessel length and the microvessel distribution; (3) the total number of isolated fibroblast-like cells and their distribution. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by various concentrations of vascular endothelial growth factor (VEGF). In addition, by evaluating a new parameter, the fibroblast-like cell distribution, our results show that: (1) during spontaneous angiogenic response, maximal fibroblast-like cell migration delimits microvascular outgrowth; and (2) the known angiogenic inhibitor Batimastat prevents endothelial cell sprouting without completely blocking fibroblast-like cell migration. Finally, this new method of quantification is of great interest to better understand angiogenesis and to test pro- or anti-angiogenic agents. [less ▲]

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See detailSpirometric performance in Belgian Blue calves: II. Analysis of environmental factors and estimation of genetic parameters.
Bureau, Fabrice ULg; Michaux, C.; Coghe, J. et al

in Journal of Animal Science (2001), 79(5), 1162-1165

Genetic parameters and environmental effects for spirometric variables (SV) in calves were estimated using 734 Belgian Blue calves (15 to 297 d of age), sired by 20 AI bulls. For each calf, the following ... [more ▼]

Genetic parameters and environmental effects for spirometric variables (SV) in calves were estimated using 734 Belgian Blue calves (15 to 297 d of age), sired by 20 AI bulls. For each calf, the following SV were measured: 1) the average ventilation (l/min) recorded during the 15 s of maximal ventilatory changes induced by lobeline administration (0.25 mg/kg, i.v.) (15-s MV(L)); 2) the vital capacity, and the maximal peak expiratory and inspiratory flows recorded after lobeline administration; and 3) the ventilatory reserve (15-s MV(L) - ventilation at rest). Analysis of environmental factors showed age of calf, herd, sex, and vaccination status had significant effects on SV. A sire model and a multiple-trait derivative-free REML procedure were used to estimate genetic parameters for SV, body weight, and muscling score. Heritabilities for SV ranged from 0.28 +/- 0.11 to 0.44 +/- 0.16. Genetic correlations among SV varied from 0.76 to 0.98 and environmental correlations from 0.69 to 0.80. Genetic correlations of SV with body weight (0.25 to 0.56) and with muscling score (0.21 to 0.76) were positive, as were environmental correlations of SV with body weight (0.44 to 0.70) and muscling score (0.09 to 0.25). These results suggest that selection may improve SV without impairing other traits of economic importance. [less ▲]

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See detailA recombinant beta-O-glucosidase from Caldocellum saccharolyticum to hydrolyse desulfo-glucosinolates
Wathelet, Jean-Paul ULg; Iori, R.; Leoni, O. et al

in Biotechnology Letters (2001), 23(6), 443-446

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum ... [more ▼]

Glucosinolates, natural compounds found in Brassicaceae, can easily be transformed into desulfo-glucosinolates by action of Helix pomatia sulfatase. The recombinant beta -O-glucosidase from Caldocellum saccharolyticum does not catalyse glucosinolate degradation but can hydrolyse desulfo-glucosinolates (thio-D-glucosidic substrates) to produce the corresponding pure nitriles, including valuable homochiral representatives. [less ▲]

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See detailQualité des soins et qualité de vie des enfants atteients de pathologies anorectales et de leurs familles
Noirhomme-Renard, Florence ULg

in Bulletin d'Education du Patient à sa Maladie (2001)

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See detailOn Conducting Burden-of-Osteoporosis Studies: A Review of the Core Concepts and Practical Issues. A Study Carried out under the Auspices of a Who Collaborating Center
Ben Sedrine, Wafa ULg; Radican, L.; Reginster, Jean-Yves ULg

in Rheumatology (2001), 40(1), 7-14

Osteoporosis is a problem that is relevant to public health from the clinical, economic and social viewpoints. Except in a handful of industrialized countries, there is a considerable void in our ... [more ▼]

Osteoporosis is a problem that is relevant to public health from the clinical, economic and social viewpoints. Except in a handful of industrialized countries, there is a considerable void in our knowledge of the magnitude of the problem. By exploring both the epidemiological and the economic impact of osteoporosis and the fractures associated with it in a particular country, studies of the 'burden of illness' (BOI) can fill that void. BOI analysis raises many questions at both the conceptual and the practical level. The purpose of this paper is to review the methodology underlying analyses of this type, to discuss its limitations and to provide a general format to improve their implementation in the field of osteoporosis. Investigators involved in BOI analysis should be very clear and explicit regarding the methods they adopt, so that studies in different countries can be interpreted and compared appropriately by interested parties. [less ▲]

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See detailDuck plague: a permanent threat for domestic and wild anatids
Marlier, Didier ULg; Jaumin, F.; Delleur, V. et al

in Annales de Médecine Vétérinaire (2001), 145(5, NOV-DEC), 287-291

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current ... [more ▼]

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current knowledge about this viral infection. [less ▲]

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See detailAutosomal recessive segregation of a truncating mutation of anti-Mullerian type II receptor in a family affected by the persistent Mullerian duct syndrome contrasts with its dominant negative activity in vitro.
Messika-Zeitoun, L.; Gouedard, L.; Belville, C. et al

in Journal of Clinical Endocrinology and Metabolism (2001), 86(9), 4390-7

Anti-Mullerian hormone belongs to the TGFbeta family whose members exert their effects by signaling through two related serine/threonine kinase receptors. Mutations of the anti-Mullerian hormone type II ... [more ▼]

Anti-Mullerian hormone belongs to the TGFbeta family whose members exert their effects by signaling through two related serine/threonine kinase receptors. Mutations of the anti-Mullerian hormone type II receptor occur naturally, causing the persistent Mullerian duct syndrome. In a family with two members with persistent Mullerian duct syndrome and one normal sibling, we detected two novel mutations of the anti-Mullerian hormone type II receptor gene. One, transmitted by the mother to her three sons, is a deletion of a single base leading to a stop codon, causing receptor truncation after the transmembrane domain. The other, a missense mutation in the substrate-binding site of the kinase domain, is transmitted by the father to the two sons affected by persistent Mullerian duct syndrome, indicating a recessive autosomal transmission as in other cases of persistent Mullerian duct syndrome. Truncating mutations in receptors of the TGFbeta family exert dominant negative activity, which was seen only when each of the mutant anti-Mullerian hormone receptors was overexpressed in an anti-Mullerian hormone-responsive cell line. We conclude that assessment of dominant activity in vitro, which usually involves overexpression of mutant genes, does not necessarily produce information applicable to clinical conditions, in which mutant and endogenous genes are expressed on a one to one basis. [less ▲]

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See detailGiacomo Leopardi e Francesco Guicciardini
Moreno, Paola ULg

in Studi e Problemi di Critica Testuale (2001), LXII

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See detailStratification of single-vessel coronary stenosis by ischemic threshold at the onset of wall motion abnormality during continuous monitoring of left ventricular function by semisupine exercise echocardiography.
Garot, J.; Hoffer, E. P.; Monin, J. L. et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2001), 14(8), 798-805

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary ... [more ▼]

We studied the relation between the ischemic threshold at the onset of wall motion abnormality on exercise echocardiography (EE) and the severity of coronary stenosis in patients with 1-vessel coronary artery disease (CAD). We screened 216 consecutive patients who underwent coronary angiography and EE for suspected CAD. Ninety-five (74 men; age, 56 +/- 12 years) satisfied the study criteria, that is, the presence of 1-vessel disease or no evidence of CAD on angiography and a normal baseline echocardiogram. Eighty-seven patients had 1-vessel CAD on angiography, and exercise-induced wall motion abnormality occurred in 73 (77%). Optimal cutoff values of percent diameter stenosis and minimal lumen diameter for predicting a positive EE were 61% (sensitivity and specificity of 76%) and 1.12 mm (sensitivity and specificity of 74%). Among patients with positive EE, heart rate-blood pressure product at ischemic threshold was correlated with quantitative coronary stenosis (r = -0.72, P <.001). The ischemic threshold from continuous monitoring of left ventricular function during semisupine EE is correlated with the severity of coronary stenosis among patients with 1-vessel disease and a normal resting echocardiogram. [less ▲]

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See detailIntact Implicit learning in Schizophrenia
Danion, Jean-Marie; Meulemans, Thierry ULg; Kauffmann-Muller, F. et al

in American Journal of Psychiatry (The) (2001), 158(6), 944-948

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See detailUn oracle médical de Sarpédon à Séleucie du Calycadnos
Nissen, Cécile ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2001), 14

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See detailErratum: High-energy forward scattering and the Pomeron: Simple pole versus unitarized models [Phys. Rev. D 61, 034019 (2000)]
Cudell, Jean-René ULg; Ezhela, V.; Kang, K. et al

in Physical Review. D : Particles and Fields (2001), 63

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See detailLes configurations de risques comme approche de la résilience dans une étude longitudinale
Boët, S.; Born, Michel ULg

in Revue Québécoise de Psychologie (2001), 22(1), 93-116

Cette recherche s'inscrit dans le cadre d'une étude longitudinale des facteurs de risque et de protection en délinquance juvénile. Nous avons observé les pratiques éducatives de la mère ainsi que le ... [more ▼]

Cette recherche s'inscrit dans le cadre d'une étude longitudinale des facteurs de risque et de protection en délinquance juvénile. Nous avons observé les pratiques éducatives de la mère ainsi que le comportement de l'enfant de sa naissance à cinq ans. Nous avons pu mettre en évidence quatre configurations de risque familial qui s'avèrent contenir nombre des enfants les plus turbulents de notre échantillon. Cependant, ces configurations rassemblent aussi des enfants qui ne manifestent aucun trouble comportemental, ce sont des enfants que nous considérons comme résilients. [less ▲]

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See detailLe diagnostic des dermatophytoses passe par l'examen de laboratoire
Mignon, Bernard ULg

in Hebdo Vétérinaire (2001), 57

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See detailDynamics of mononuclear cadmium beta-lactamase revealed by the combination of NMR and PAC spectroscopy.
Hemmingsen, L.; Damblon, Christian ULg; Antony, J. et al

in Journal of the American Chemical Society (2001), 123(42), 10329-35

The two metal sites in cadmium substituted beta-lactamase from Bacillus cereus 569/H/9 have been studied by NMR spectroscopy ((1)H, (15)N, and (113)Cd) and PAC spectroscopy ((111m)Cd). Distinct NMR ... [more ▼]

The two metal sites in cadmium substituted beta-lactamase from Bacillus cereus 569/H/9 have been studied by NMR spectroscopy ((1)H, (15)N, and (113)Cd) and PAC spectroscopy ((111m)Cd). Distinct NMR signals from the backbone amides are identified for the apoenzyme and the mononuclear and binuclear cadmium enzymes. For the binuclear cadmium enzyme, two (113)Cd NMR signals (142 and 262 ppm) and two (111m)Cd PAC nuclear quadrupole interactions are observed. Two nuclear quadrupole interactions are also observed, with approximately equal occupancy, in the PAC spectra at cadmium/enzyme ratios < 1; these are different from those derived for the binuclear cadmium enzyme, demonstrating interaction between the two metal ion binding sites. In contrast to the observation from PAC spectroscopy, only one (113)Cd NMR signal (176 ppm) is observed at cadmium/enzyme ratios < 1. The titration of the metal site imidazole (N)H proton signals as a function of cadmium ion-to-enzyme ratio shows that signals characteristic for the binuclear cadmium enzyme appear when the cadmium ion-to-enzyme ratio is between 1 and 2, whereas no signals are observed at stoichiometries less than 1. The simplest explanation consistent with all data is that, at cadmium/enzyme ratios < 1, the single Cd(II) is undergoing exchange between the two metal sites on the enzyme. This exchange must be fast on the (113)Cd NMR time scale and slow on the (111m)Cd PAC time scale and must thus occur in a time regime between 0.1 and 10 micros. [less ▲]

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See detailComparative study of twenty nine non parametric interaction tests in two-way layouts
Van Belle, Laurent; Claustriaux, Jean-Jacques ULg

in Multiciência (2001), 4(2), 179-196

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See detailSensor arrays : an inspired idea or an objective measurement of environmental odours ?
Stuetz, R. M.; Nicolas, Jacques ULg

in Water Science & Technology (2001), 44(9), 53-58

The measure of annoyance odours from sewage treatment, landfill and agricultural practise has become highly significant in the control and prevention of odorous emissions from existing facilities and is ... [more ▼]

The measure of annoyance odours from sewage treatment, landfill and agricultural practise has become highly significant in the control and prevention of odorous emissions from existing facilities and is crucial for new planning applications. Current methods (such as GC-MS analysis, H2S and NH3 measurements) provide an accurate description of chemical compositions or act as surrogates for odour strength, but tell us very little about the perceived effect, whereas olfactometry gives the right human response but is very subjectivity and expensive. The use of non-specific sensor arrays may offer an objective and on-line instrument for assessing olfactive annoyance. Results have shown that sensor array systems can discriminate between different odour sources (wastewater, livestock and landfill). The response patterns from these sources can be significantly different and that the intensity of sensor responses is proportional to the concentration of the volatiles. The correlation of the sensors responses against odour strengths have also shown that reasonable fits can be obtained for a range of odour concentrations (100 - 800,000 ou/m3). However, the influence of environmental fluctuations (humidity and temperature) on sensor baselines still remains an obstacle, as well as the need for periodic calibration of the sensory system and the choice of a suitable gas for different environmental odours. [less ▲]

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See detailPositive Actie (Affirmative Action) : een middel tegen racisme ?
Martiniello, Marco ULg

in Noord-Zuid Cahier (2001), 26(1), 83-91

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See detailLes rudistes de la Mésogée. Anatomie et biotope.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (2001), 58

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See detailFine-mapping and construction of a bovine contig spanning the ovine callipyge locus.
Shay, T. L.; Berghmans, S.; SEGERS, Karin ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (2001), 12(2), 141-9

The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human ... [more ▼]

The callipyge (CLPG) gene was fine-mapped by linkage analysis to a 4.6-cM chromosome interval on distal ovine OAR18q, flanked by microsatellite markers IDVGA30 and OY3. The OAR18q linkage map and human HSA14q transcript map were aligned by genotyping two bovine-hamster whole-genome radiation hybrid panels with the microsatellite markers, as well as with sequences corresponding to HSA 14q genes. Using Type I loci mapping to the IDVGA30-OY3 interval as anchor points, we have constructed a 1.4-Mb bovine BAC contig containing the IDVGA30-OY3 interval. We demonstrate that the IDVGA30-OY3 interval spans approximately 770 kb and contains at least four genes: YY1, WARS, DLK1, and GTL2. [less ▲]

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See detailUne révision critique de la distribution de Tortula inermis en Belgique
Vanderpoorten, Alain ULg; Stieperaere, H.; Sotiaux, André ULg

in Dumortiera (2001), 77

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See detailLes insectes aquatiques du ru de Targnon (Commune de Theux)
Dethier, Michel; Dopagne, Claude ULg

in Natura Mosana (2001), 54(4), 67-76

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See detailThe NETLANDER Ionosphere and Geodesy Experiment
Barriot, Jean-Pierre; Dehant, Véronique; Folkner, W. et al

in Advances in Space Research (2001), 28(8), 1237-1249

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See detailComment les élèves apprennent-ils l'algèbre ?
Vlassis, Joëlle ULg; Demonty, Isabelle ULg

in Informations Pédagogiques (2001), 134

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See detailLes maisons de justice: une révolution tranquille?
Dantinne, Michaël ULg; Simon, Julie

in Actualités du Droit (2001)

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See detailLa sensibilisation du personnel dans le cadre de la mise en place d'un système de management environnemental : une porte d'entrée pour l'éducation relative à l'environnement dans l'entreprise ?
Domasik, Marie-Claire ULg; Semal, Nathalie ULg; Von Frenckell, Marianne ULg

in Education relative à l'environnement- Regards, recherches, réflexions (2001), 3

The increasing needs of enterprises in environmental training, in relation with the rise in environmental management systems in Belgium, generate new research needs in environmental education (EE) scope ... [more ▼]

The increasing needs of enterprises in environmental training, in relation with the rise in environmental management systems in Belgium, generate new research needs in environmental education (EE) scope. The authors experience shows that the entreprises’ expectations can meet EE objectives, and that environmental awareness programs for corporate employees can enable them to adapt their professionnal and private behaviour. This efficiency is based on interactive designing of training actions, responsability sharing and mutual learning. However, EE efficiency in enterprises depends on corporate culture and its capacity to evolve. [less ▲]

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See detailPrincipes et intérêts du simulateur en anesthésie-réanimation
Larbuisson, Robert ULg; Nyssen, Anne-Sophie ULg; Janssens, Marc ULg et al

in Praticien en Anesthésie Réanimation (Le) (2001), 5(4), 225

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See detailAPRIL IN CHICAGO
Sacré, Robert ULg

in Soul Bag (2001), (163), 50

The Center for Black Music Research sur le web . Scènes du blues et du gospel

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See detailLes médias belges et l'"Etat social actif" : genèse, reproduction et diffusion du nouveau sens commun socio-économique
Geuens, Geoffrey ULg

in Quaderni : la Revue de la Communication (2001), 45 ("Figures du journalisme")

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See detailLes réserves d’interprétation dans la jurisprudence de la Cour d’arbitrage : une alternative à l’annulation
Rosoux, Géraldine ULg

in Revue Belge de Droit Constitutionnel (2001)

The article gives an overview upon constitutional decisions rejecting "under condition" actions for anulment.

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See detailEditorial: Les Systèmes de production agricole et la protection des cultures à la croisée des chemins
Lepoivre, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(4), 195-199

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See detailLe Bestiaire des philosophes indiens
Verpoorten, Jean-Marie ULg

in Acta Orientalia Belgica (2001)

Compilation de textes (avec leurs traductions) relatifs aux animaux dans les œuvres de deux grammairiens (Patañjali I et Bhartṛhari II) et de cinq courants philosophiques (MīmāṃsāIII, NyāyaIV, VaiśeṣikaV ... [more ▼]

Compilation de textes (avec leurs traductions) relatifs aux animaux dans les œuvres de deux grammairiens (Patañjali I et Bhartṛhari II) et de cinq courants philosophiques (MīmāṃsāIII, NyāyaIV, VaiśeṣikaV, Sāṃkhya VI et YogaVII). L’animal le plus souvent mentionné est le « bovin » dont le nom (go) pose le problème de sa dénotation : est-ce l’animal individuel ou la classe « bovin » ? Il faut qu’il dénote l’individu, car, dans la phrase « il donne la vache au médecin », go ne peut pas s’appliquer à l’espèce «vache » Un second problème (I et II) est celui de la « comparaison » (upamāna) : qu’est-ce qui permet de reconnaître un bovin sauvage à partir de la connaissance d’un bovin domestique ? Quel nom donner à tel animal à partir de similitudes partielles avec tel autre ? Où est le détail caractéristique qui distingue le bovin du gayal (I, III) ? Une trop grande différence entre deux entités (par ex.un bovin et un cheval) rend impossible l’upamāna (IV). Le serpent et ses anneaux sont analogues à un substrat permanent et à ses formes changeantes (IV) Quand on regarde soit un cerf courir, soit un merle ou un cygne voler, c’est l’animal qu’on voit et non l’acte de courir ou voler (II) . En effet un acte comme tel n’est pas comparable à un autre car tous deux sont inachevés. En épistémologie, l’erreur est souvent illustrée par la confusion dans la pénombre entre une corde et un serpent (II) Des problèmes sont soulevés à propos des injonctions et interdictions rituelles. Tel animal à immoler, dont le nom est au singulier, vaut pour un groupe entier ou une espèce ; telle interdiction ne mentionne explicitement que le chien et le chat comme à écarter du gâteau sacrificiel, alors que le corbeau devrait l’être aussi (III). D’autre part, s’il faut immoler un lion ou un bœuf , on se gardera d’immoler soit un homme sous prétexte qu’il est courageux comme un lion ou balourd comme un boeuf. Le problème est parfois d’ordre grammatical. L’adjectif kāpota « de pigeon » qualifie ce qui appartient à l’oiseau vivant ; peut-on dès lors l’employer pour une «soupe de pigeon » où manifestement l’oiseau est mort (I) ? D’autre part, comment le mot go peut-il s’appliquer à des vaches de terre cuite, puisqu’elles ne sont pas vivantes (IV). Et si des gâteaux de farine en forme de lions c’est par ressemblance aux lions vivants. Le métaphorique est fondé sur ce qui ne l’est pas(III) Au plan ontologique, le bouddhiste soutient que les qualités existent sans le support d’une substance L’illustre le fait qu’une cigogne dans la pénombre se limite à une tache de couleur (IV) La logique est abordée en V via la confrontation entre deux raisonnements, le bon : « puisque c’est cornu, c’est un bovin » et le mauvais : « puisque c’est cornu, c’est un cheval » Notons enfin que VI classe animaux et insectes en qualité de résidences pour les humains réincarnés et que VII énumère des postures yogiques qui portent des noms d’animaux. Une liste de ceux-ci clôt cette étude. [less ▲]

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See detailEffects of allelochemicals from first (Brassicaceae) and second (Myzus persicae and Brevicoryne brassicae) trophic levels on Adalia bipunctata
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Journal of Chemical Ecology (2001), 27(2), 243-256

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the ... [more ▼]

Three Brassicaceae species, Brassica napus (low glucosinolate content), Brassica nigra (including sinigrin), and Sinapis alba (including sinalbin) were used as host plants for two aphid species: the generalist Myzus persicae and the specialist Brevicoryne brassicae. Each combination of aphid species and prey host plant was used to Feed the polyphagous ladybird beetle, Adalia bipunctata. Experiments with Brassicaceae species including different amounts and kinds of glucosinolates (GLS) showed increased ladybird larval mortality at higher GLS concentrations. When reared on plants with higher GLS concentrations, the specialist aphid, B. brassicae, was found to be more toxic than M. persicae. Identification of GLS and related degradation products, mainly isothiocyanates (ITC), was investigated in the first two trophic levels, plant and aphid species, by high-performance liquid chromatography and gas chromatography-mass spectrometry, respectively. While only GLS were detected in M. persicae on each Brassicaceae species, high amounts of ITC were identified in B. brassicae samples (allyl-ITC and benzyl-ITC from B. nigra and S. alba, respectively) from all host plants. Biological effects of allelochemicals from plants on predators through aphid prey are discussed in relation to aphid species to emphasize the role of the crop plant in integrated pest management in terms of biological control efficacy. [less ▲]

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See detailLes manuels scolaires en Belgique francophone
Merenne-Schoumaker, Bernadette ULg

in Travaux de l’Institut de Géographie de Reims (2001), (109-110), 83-91

This article tries to evaluate the evolution of both the status and the content of geography’s textbooks in the French part of Belgium. With this aim in view, three periods are analysed : before the ... [more ▼]

This article tries to evaluate the evolution of both the status and the content of geography’s textbooks in the French part of Belgium. With this aim in view, three periods are analysed : before the renovation of the teaching, the years 1980-1990 and today. Through the mutations, narrows links are confirmed between the teaching’s aims and the role devoted to the textbooks. [less ▲]

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See detailConsumer Evaluations of Brand Extensions: Differences between Goods and Services
Van Riel, Allard ULg; Lemmink, Jos; Ouwersloot, Hans

in Journal of Service Research (2001), 3(3), 220-231

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See detailNeuromuscular transmission in migraine: a single-fiber EMG study in clinical subgroups.
Ambrosini, Anna; Maertens De Noordhout, Alain ULg; Schoenen, Jean ULg

in Neurology (2001), 56(8), 1038-43

OBJECTIVE: To search for impairment of neuromuscular transmission by single-fiber electromyography (SFEMG) in patients with common forms of migraine. BACKGROUND: P/Q Ca(2+) channels are genetically ... [more ▼]

OBJECTIVE: To search for impairment of neuromuscular transmission by single-fiber electromyography (SFEMG) in patients with common forms of migraine. BACKGROUND: P/Q Ca(2+) channels are genetically abnormal in most cases of familial hemiplegic migraine (International Headache Society [IHS] code 1.2.3) and may be involved in other types of migraine. Besides in the brain, these channels are found in motor nerve endings, where they control stimulation-induced acetylcholine release. If they are functionally abnormal, the neuromuscular transmission might be impaired. METHODS: Sixty-two migraineurs (18 without aura, IHS code 1.1; 19 with typical aura, IHS code 1.2.1; 10 with prolonged aura, IHS code 1.2.2; 15 with and without aura) and 16 healthy control subjects underwent stimulation SFEMG. Results were expressed as the mean value of consecutive differences (MCD) and percentage of single-fiber abnormalities (abnormal jitter or impulse blocking). RESULTS: Average MCD was comparable in control subjects and migraineurs (17.1 +/- 2.6 versus 17.5 +/- 4.7 microsec). By contrast, single-fiber abnormalities were found in 17 patients but in none of the control subjects (p = 0.036). Most of these patients had unilateral sensorimotor symptoms and/or aphasia and/or loss of balance during the aura. SFEMG abnormalities were significantly correlated with the occurrence of these clinical features and with a diagnosis of migraine with prolonged aura. CONCLUSIONS: Stimulation SFEMG shows mild abnormalities of neuromuscular transmission in a subgroup of migraineurs with aura, characterized by clinical features frequently found in human P/Q Ca(2+) channelopathies. These abnormalities might thus be due to genetically modified P/Q Ca(2+) channels. [less ▲]

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See detailL'etude clinique du mois. Toxicite de l'hyperglycemie en soins intensifs et effets benefiques d'une insulinotherapie optimisee.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(12), 859-61

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were ... [more ▼]

A large Belgian, prospective, controlled study was performed in 1.548 critically ill patients (83% without history of diabetes) hospitalised in a surgical intensive care unit. On admission, patients were randomly assigned to receive intensive intravenous insulin therapy (maintenance of blood glucose at a level between 80 and 110 mg/dl) or conventional treatment (infusion of insulin only if the blood glucose level exceeded 215 mg/dl and maintenance of glucose at a level between 180 and 200 mg/dl). Intensive insulin therapy reduced morbidity and mortality by 40%. These remarkable results should influence further therapeutical attitudes in intensive care units and open new perspectives for the management of critically ill patients. [less ▲]

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See detailThe prevalence of mycotoxins in Kashin-Beck disease
Haubruge, Eric ULg; Chasseur, Camille; Debouck, Catherine et al

in International Orthopaedics (2001), 25

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See detailPharma-clinics. Le medicament du mois. Le repaglinide (NovoNorm).
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(6), 456-9

Repaglinide (NovoNorm) is an antidiabetic oral agent of the new glinide class with insulinotropic activity. Its action on insulin secretion is more rapid and shorter than that of sulphonylurea compounds ... [more ▼]

Repaglinide (NovoNorm) is an antidiabetic oral agent of the new glinide class with insulinotropic activity. Its action on insulin secretion is more rapid and shorter than that of sulphonylurea compounds. Thanks to these properties, repaglinide is able to better control postprandial hyperglycaemia and is associated with a lower risk of delayed hypoglycaemic episodes. It is indicated for the treatment of type 2 (non-insulin-dependent) diabetes mellitus as monotherapy, after diet failure, or in combination with metformin, when the biguanide is insufficient. NovoNorm is commercialized as tablets of 0.5, 1 and 2 mg, to be taken just before each meal. Initial dosis should be 0.5 mg before meal in diabetic patients on diet alone or 1 mg before meal in patients already receiving an hypoglycaemic agent. If necessary, the dosis should be progressively increased, depending on the individual response, up to 4 mg before meal (maximal daily dosage of 16 mg), in order to optimize blood glucose control. [less ▲]

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See detailIncrease of Plasma Ecg Binding Rate after Administration of Repeated High Dose of Ecg to Cows
Drion, Pierre ULg; De Roover, R.; Houtain, J. Y. et al

in Reproduction Nutrition Development (2001), 41(3), 207-215

Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this ... [more ▼]

Equine chorionic gonadotrophin (eCG) is still used to promote follicular growth in cattle and, more recently with an increased frequency of administration, in ovum pick-up protocols. The aim of this experiment was to verify the possible effect of high frequency of administration on the immune response to eCG. The profiles of eCG binding rate, in the blood of two groups (A, B) of 4 primiparous cross breed beef cows (3-3.5 years old) submitted weekly for 5 to 10 weeks to repeated high doses (1000-2000 IU) of equine chorionic gonadotrophin, are presented in this paper. A sensitive radiometric method was used to detect antibodies in plasma. The profiles clearly indicated a marked increase of eCG binding rate after 3 to 5 injections of the exogenous hormone to the females. The statistical analysis of the results established that treatments induced a significant increase (P < 0.01) in binding rates after 6 and 3 injections in group A and B respectively. These binding rates remained elevated for at least 1 week following the last injection and decreased afterwards. The values of plasma binding rates following repeated eCG administration differed significantly between groups (0.90+/-1.04 and 1.04+/-0.11 for groups A and B before treatment versus 11.77+/-0.92, 6.70+/-0.85 for groups A and B after treatment, P < 0.01) and from one cow to another (P < 0.01) with some cows presenting no significant immune response while others were more reactive against the hormone (at least 3 injections). [less ▲]

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See detailExploring Consumer Evaluations of e-Services: A Portal Site
Van Riel, Allard ULg; Liljander, Veronica

in International Journal of Service Industry Management (2001), 12(4), 359-377

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See detailOrdovician cryptospores from the Oostduinkerke borehole, Brabant Massif, Belgium
Steemans, Philippe ULg

in Geobios (2001), 34(1), 3-12

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See detailSome properties of generalized age-distribution equations in fluid dynamics
Beckers, Jean-Marie ULg; Delhez, Eric ULg; Deleersnijder, Eric

in SIAM Journal on Applied Mathematics (2001), 61(5), 1526-1544

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry ... [more ▼]

The concept of age in fluid dynamics is analyzed in the case of a tracer advection-diffusion equation. From the general solution in a uniform velocity field, it is shown that unexpected symmetry properties arise for the age field. In particular, for a point release, the age field is isotropic, regardless of the direction of the ow and the value of the diffusion coefficient. The analysis is then extended to situations with time-varying currents, where the symmetry can be broken under some circumstances. Finally, we show a method by which a time-dependent problem can be used to assess a stationary concentration distribution function, providing details about the propagation of younger and older material at a given location. [less ▲]

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See detailConstitutive equations and numerical modelling of time effects in soft porous rocks
Datcheva, Maria; Charlier, Robert ULg; Collin, Frédéric ULg

in Lecture Notes in Computer Science (2001), 1988

A constitutive model is developed within the framework of Perzyna's viscoplasticity for predicting the stress-strain-time behaviour of soft porous rocks. The model is based on the hyperelasticity and ... [more ▼]

A constitutive model is developed within the framework of Perzyna's viscoplasticity for predicting the stress-strain-time behaviour of soft porous rocks. The model is based on the hyperelasticity and multisurface viscoplasticity with hardening. A time-stepping algorithm is presented for integrating the creep sensitive law. An example of application to one-dimensional consolidation is presented. The objectives are to: 1. present a soft rock model which is capable of taking into account the rate sensitivity, time effects and creep rupture; 2. to discuss the use of an incremental procedure for time stepping using large time increments and 3. to extend the finite element code Lagamine (MSM-ULg) for viscoplastic problems in geomechanics. [less ▲]

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See detailSerum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria.
Verhoef, H.; West, C. E.; Ndeto, P. et al

in American Journal of Clinical Nutrition (2001), 74(6), 767-75

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum ... [more ▼]

BACKGROUND: Serum transferrin receptor concentrations indicate both erythropoietic activity and the deficit of functional iron in the erythron. In contrast with serum ferritin concentrations, serum transferrin receptor concentrations are not or are only marginally influenced by the inflammatory response to infection. OBJECTIVE: We assessed iron status and examined the relation between serum transferrin receptor concentrations and malaria in children aged 2-36 mo who were asymptomatic for malaria. DESIGN: This was a community-based cluster survey (n = 318). RESULTS: Prevalences of malaria, anemia (hemoglobin concentration <110 g/L), iron deficiency (serum ferritin concentration <12 microg/L), and iron deficiency anemia were 18%, 69%, 53%, and 46%, respectively. Malaria was associated with lower mean hemoglobin concentrations (92.7 compared with 104.1 g/L; P = 0.0001) and higher geometric mean serum concentrations of transferrin receptor (11.4 compared with 7.8 mg/L; P = 0.005), ferritin (21.6 compared with 11.9 microg/L; P = 0.05), and C-reactive protein (12.5 compared with 6.8 mg/L; P = 0.004). There was no evidence for an association between serum concentrations of C-reactive protein and transferrin receptor. Children with malaria had higher serum transferrin receptor concentrations than expected for the degree of anemia, even after adjustment for inflammation indicated by serum C-reactive protein concentration quartiles (P = 0.02). CONCLUSIONS: Our findings are consistent with the notion that malaria-induced hemolysis is accompanied by increased erythropoiesis. Serum transferrin receptor concentration is not useful for detecting iron deficiency in individuals with malaria. Individuals with high concentrations of serum C-reactive protein or similar acute phase reactants should be excluded from analysis if serum ferritin concentrations <12 microg/L are to be used to measure iron deficiency in malaria-endemic areas. [less ▲]

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See detailThe Pyoverdin Of Pseudomonas Fluorescens Btp2, A Novel Structural Type
Ongena, MARC ULg; Jacques, Philippe ULg; Thonart, Philippe ULg et al

in Tetrahedron Letters (2001), 42(34),

Abstract—From Pseudomonas fluorescens BTP2 a pyoverdin was isolated which contained the so far not encountered Val in its peptide chain. Its structure could be elucidated by chemical degradation and ... [more ▼]

Abstract—From Pseudomonas fluorescens BTP2 a pyoverdin was isolated which contained the so far not encountered Val in its peptide chain. Its structure could be elucidated by chemical degradation and spectroscopic data. [less ▲]

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See detailEffects of liming on forest soil algal communities
Kostinov, I.; Carnol, Monique ULg; Dulière, J.-F. et al

in Algological Studies (2001), 102

The effects of the application of dolomite lime (5 t ha-1) on soil algal communities were investigated in sessile oak (Quercus petraea (MATT.) LIEB.) and Norway spruce (Picea abies (L.) KARST.) plots ... [more ▼]

The effects of the application of dolomite lime (5 t ha-1) on soil algal communities were investigated in sessile oak (Quercus petraea (MATT.) LIEB.) and Norway spruce (Picea abies (L.) KARST.) plots situated in the Belgian Ardenne. Chlorophyta (60 taxa) were by far the most diverse group, followed by Xanthophyceae (10 taxa), Bacillariophyceae (3 taxa), Cyanophyceae (2 taxa) and Euglenophyceae (1 taxon). In both forest types, liming lead to a significant increase in soil pH, exchangeable magnesium and calcium. In the limed Quercus plots available phosphorus and soil solution nitrate concentrations were also increased. The soil algal diversity was similar in oak and spruce control plots and in limed spruce plots. However, in the limed oak plots a significantly higher algal diversity was observed. On the basis of a CCA analysis, three clusters of plots could be distinguished: a) Picea control plots, b) limed Picea and control Quercus plots, c) limed Quercus plots. Both soil pH and nutrient availability seem to be important in determining algal species composition in these forest soils. [less ▲]

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See detailTetraethyl(Pyrrolidine-2,2-diyl)Bisphosphonate
Olive, Gilles ULg; Jacques, Alain

in Molecules (2001), 6

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See detailAbsence of protective effect of oral insulin on residual ß-cell function in type 1 diabetes
Geenen, Vincent ULg

in International Diabetes Monitor (2001), 13

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See detailCrystallization and preliminary X-ray analysis of a bacterial psychrophilic enzyme, phosphoglycerate kinase
Mandelman, D.; Bentahir, M.; Feller, Georges ULg et al

in Acta Crystallographica Section D-Biological Crystallography (2001), 57(Pt 11), 1666-8

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and ... [more ▼]

The glycolytic enzyme phosphoglycerate kinase (PGK) from the Antarctic microorganism Pseudomonas sp. TACII18 is a cold-adapted enzyme that displays a high specific activity at low temperatures and decreased thermostability relative to its mesophilic counterpart. Herein, the preliminary crystallization and structure solution of psychrophilic PGK in its native form and cocrystallized with 3-phosphoglyceric acid (3-PGA) and the ATP analogue adenylyl imidophosphate (AMP-PNP) is reported. The complexed form of PGK crystallized in 2-3 d at 290 K, whereas the native form of the enzyme required 8-12 months. Morphologically, both crystal forms are similar and X-ray diffraction experiments indicate that the crystals are isomorphous. The crystals diffracted to a resolution of 2.0 A and belong to the space group P3(2). with unit-cell parameters a = b = 58.5, c = 85.4 A. [less ▲]

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See detailUtilisation des gènes à effet majeur en sélection laitière. Un exemple: le gène Pit-1
Renaville, Robert ULg; Parmentier, Isabelle; Fontaine, Sandrine et al

in Les Elevages belges (2001), 4

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See detailHistologic localization of PLAG1 (pleomorphic adenoma gene 1) in pleomorphic adenoma of the salivary gland: cytogenetic evidence of common origin of phenotypically diverse cells.
Debiec-Rychter, M.; Van Valckenborgh, I.; Van den Broeck, C. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (2001), 81(9), 1289-97

Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearranged and overexpressed in human pleomorphic adenomas of the salivary glands with 8q12 translocations. In ... [more ▼]

Pleomorphic adenoma gene 1 (PLAG1), a zinc finger transcription factor gene, is consistently rearranged and overexpressed in human pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we describe the immunohistochemical localization of PLAG1 protein in pleomorphic adenomas of the salivary gland and corresponding normal tissue, in relation to cytokeratin, vimentin, and BCL-2 expression. Normal salivary gland tissue was not immunoreactive for PLAG1. In primary pleomorphic adenomas, cells strongly immunoreactive for PLAG1 were detected in the outer layer of tubulo-ductal structures, which are thought to be the origin of cells with bi-directional, epithelial, and mesenchymal phenotypes. In contrast, epithelial cells with abundant cytokeratin in the inner tubulo-ductal structures only sporadically expressed PLAG1. BCL-2 immunoreactivity was found mainly in the cells surrounding the tubulo-ductal structures and in the solid undifferentiated cellular masses, within the areas that had moderate PLAG1 immunoreactivity. The variability of PLAG1 expression in neoplastic cells seemed to reflect the morphologic heterogeneity that correlated with the stage of differentiation of the tumor cells. Immunohistochemical/cytogenetic evaluation of two pleomorphic adenomas with t(3;8)(p21;q12) or t(5;8)(p13;q12) translocations demonstrated the clonal nature of immunophenotypically diverse cells. This finding confirms the theory that pleomorphic adenoma cells share a common single-cell origin, most likely from the epithelial progenitor basal duct cells. [less ▲]

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailMapping Aging Effects on Polymer Surfaces : Specific Detection of Additives by Chemical Force Microscopy
Duwez, Anne-Sophie ULg; Nysten, Bernard

in Langmuir (2001), 17

We report in this contribution the successful application of chemical force microscopy to study aging of polymer surfaces at the submicroscopic scale. Adhesion force mapping using tips modified with ... [more ▼]

We report in this contribution the successful application of chemical force microscopy to study aging of polymer surfaces at the submicroscopic scale. Adhesion force mapping using tips modified with methyland hydroxyl-terminated alkanethiols was used to probe the chemical composition of polypropylene surfaces as a function of aging time. We have measured adhesion force distributions on polypropylene melt-pressed films stabilized with antioxidants, process-stabilizing agents, and UV-light stabilizers. These adhesion force distributions were correlated with the additive distribution at the surface. We were able to evidence modifications of the local adhesion properties on the polymer surface due to material aging. These results support the conclusion that the UV-light stabilizer migrates toward the surface and forms a film that makes the surface less hydrophobic. Laterally resolved adhesion force maps show chemically heterogeneous surfaces on a sub-100 nm scale [less ▲]

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See detailEffects of insecticide treatments on insect density and diversity in vegetable open fields.
Colignon, P.; Hastir, Pierre; Gaspar, Charles ULg et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2001), 66(2a), 403-411

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest ... [more ▼]

Vegetable open field areas increased for 15 years in Wallonia, mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agro-chimical residues (R.M.L.), biological pest control was developed and allowed to reduce the insecticide use, leading to have safer fresh products. Among cultivated species in Wallonia, leguminous crops represent more than 85% of the vegetable production. To assess the impact of insecticide treatment on both pests (mainly aphids) and beneficial insects (predators and parasitoids), broad bean (Vicia faba L.) fields were investigated during all the production duration. Twelve fields between Waremme and Hannut were visited weakly from May to July. In each field, control untreated and treated plots were investigated. Insects were caught using yellow traps and determined until the family level. Approximately 90.000 insects belonging to 59 major families (99% of captures) and 64 minor families were identified. These results showed that biodiversity in terms of family numbers was significantly higher in unsprayed plots. In addition, biodiversity and biomass (insect density) increased gradually during the season. Evaluation of pest and beneficial diversity and density was discussed in relation to aphicid (lambda-cyhalothrin, pirimicarb) treatments and the development of I.P.M. program in vegetable crops. [less ▲]

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See detailImportance of post-transcriptional regulation of chemokine genes by oxidative stress.
JOSSE, Claire ULg; Boelaert, J. R.; Best-Belpomme, M. et al

in Biochemical Journal (2001), 360(Pt 2), 321-33

The transcription factor, nuclear factor kappa B (NF-kappa B), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H(2 ... [more ▼]

The transcription factor, nuclear factor kappa B (NF-kappa B), is activated by various stimuli including cytokines, radiation, viruses and oxidative stress. Here we show that, although induction with H(2)O(2) gives rise to NF-kappa B nuclear translocation in both lymphocyte (CEM) and monocyte (U937) cells, it leads only to the production of mRNA species encoding interleukin-8 (IL-8) and macrophage inflammatory protein 1 alpha in U937 cells. Under similar conditions these mRNA species are not observed in CEM cells. With the use of a transient transfection assay of U937 cells transfected with reporter constructs of the IL-8 promoter and subsequently treated with H(2)O(2), we show that (1) IL-8-promoter-driven transcription is stimulated in both U937 and CEM cells and (2) the NF-kappa B site is crucial for activation because its deletion abolishes activation by H(2)O(2). The production of IL-8 mRNA in U937 cells is inhibited by the NF-kappa B inhibitors clasto-lactacystin-beta-lactone and E-64D (l-3-trans-ethoxycarbonyloxirane-2-carbonyl-L-leucine-3-methyl amide) but requires protein synthesis de novo. Moreover, inhibition of the p38 mitogen-activated protein kinase also decreases the IL-8 mRNA up-regulation mediated by H(2)O(2). Taken together, these results show the importance of post-transcriptional events controlled by a p38-dependent pathway in the production of IL-8 mRNA in U937. The much lower activation of p38 in CEM cells in response to H(2)O(2) could explain the lack of stabilization of IL-8 mRNA in these cells. [less ▲]

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See detailEffet de l’environnement proche sur la biodiversité entomologique en culture maraîchères de plein champ
Colignon, P.; Haubruge, Eric ULg; Hastir, P. et al

in Parasitica (2001), 56

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See detailBubble-columns : local gas holdup determination by electrical resistance tomography
Fransolet, Emmanuelle; Crine, Michel ULg; L'Homme, Guy ULg et al

in Chemie Ingenieur Technik (2001), 73

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See detailAlternative mating tactics in the alpine newt Triturus alpestris alpestris
Denoël, Mathieu ULg; Poncin, Pascal ULg; Ruwet, Jean-Claude

in Journal of Herpetology (2001), 35(1), 62-67

Sexual behaviors in dyadic encounters in the alpine newt, Triturus alpestris alpestris, is described to test whether male behavior is influenced by external cues, that is, female responsiveness. Depending ... [more ▼]

Sexual behaviors in dyadic encounters in the alpine newt, Triturus alpestris alpestris, is described to test whether male behavior is influenced by external cues, that is, female responsiveness. Depending on this factor, a male exhibits one of the two following tactics during the sperm transfer phase. The male either waits for a positive response from the female before initiating sperm transfer ("waiting" tactic), or creeps and deposits a spermatophore in front of a nonresponsive female ("luring" tactic). The sperm transfer success rates of these tactics are 31% and 6%, respectively,and encounter success rates, 64% and 8%, respectively. The success of the second tactic is linked to behaviors that lure the female, notably quiver and distal lure. The same individual can exhibit both tactics, and neither body size nor condition appears to influence the tactic a male exhibits. These tactics can be interpreted as the result of a conditional strategy, that is, a strategy that allows an individual to incorporate information about its ability to obtain fitness through alternative tactics and then express the tactic that maximizes its fitness. More particularly, these tactics are examples of a side-payment strategy, that is, a strategy that allows individuals to achieve small gains by capitalizing on passing opportunities. [less ▲]

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See detailMagnetic and conversion electron Mössbauer spectral study of amorphous thin films of DyxFe100-x and Dy20Fe80-yCoy
Fleury-Frenette, Karl ULg; Delwiche, Jacques ULg; Grandjean, Fernande ULg et al

in Journal of Applied Physics (2001), 90(4), 1934-1940

Amorphous thin films of DyxFe100-x and Dy20Fe80-yCoy, with various x and y values and of ∼40 nm thickness, have been prepared by sputtering on polyimide films. Their magnetization curves and the Mössbauer ... [more ▼]

Amorphous thin films of DyxFe100-x and Dy20Fe80-yCoy, with various x and y values and of ∼40 nm thickness, have been prepared by sputtering on polyimide films. Their magnetization curves and the Mössbauer spectra indicate that at 295 K the iron moments are preferentially oriented parallel to the film in Dy2Fe98 and that Dy6Fe94 is paramagnetic. The DyxFe100-x thin films, where x is 17, 20, 24, 29, 32, 35, and 37, show perpendicular magnetic anisotropies and moderate coercive fields of at most 150 kA/m, whereas the Dy20Fe80-yCoy thin films, where y is 8, 13, 16, and 20, thin films show stronger perpendicular anisotropies and larger coercive fields of ∼400 kA/m. The introduction of cobalt into the amorphous thin films increases their coercive field and the perpendicular magnetic anisotropy. The Mössbauer spectra of the DyxFe100-x and Dy20Fe80-yCoy amorphous thin films consist of broadened sextets which have been analyzed with a distribution of hyperfine fields by assuming that the iron moments are oriented perpendicular to the plane of the film. Detailed fits of the Mössbauer spectrum of Dy20Fe80 indicate that the cone angle of the iron magnetic moments cannot be determined with accuracy. The average hyperfine fields in the DyxFe100-x amorphous thin films are smaller than those in the crystalline dysprosium-iron intermetallic compounds. The average hyperfine field increases from ∼140 kOe in the DyxFe100-x films to ∼220 kOe in the Dy20Fe80-yCoy films, an increase which is in agreement with the increase in the saturation magnetization. The x dependence of the isomer shift indicates that there is strong dysprosium-iron bonding, whereas the y dependence of the isomer shift reveals an enhancement of the d-electron localization. From earlier x-ray magnetic circular dichroism results and the Mössbauer spectral results presented herein, iron magnetic moments of 0.87 or 0.67 μB, corresponding to 2.9 or 2.8 holes in the iron 3d band, have been obtained for the DyxFe100-x amorphous thin films with x greater or smaller than 27, respectively [less ▲]

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See detailCollaborative learning in an educational robotics environment
Denis, Brigitte ULg; Hubert, Sylviane

in Computer in Human Behavior (2001), 17(5-6), 465-480

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See detailLiberté, égalité, fraternité ou la mort ? La Cour d'arbitrage et le Vlaams Blok
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailPractical Aspects Of Computational Chemistry Calculations Through Pc Networks: The Ramses-Beowulf Implementation
Beuve-Mery, D.; Rahman, M.; Ducarme, P. et al

in Journal of Computational Chemistry (2001), 22(2), 172-7

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our ... [more ▼]

We have built clusters of PC using up to 320 processors in parallel. The first cluster was built in 1996 from 64 computers. The parallel architectures are named RAMSES. In this article, we share our experience and discuss our choices. The architecture is composed of Pentium processors connected by a 100 Mbits/s Ethernet network. Because RAMSES are built of independent computers, the system is easily maintained, and can be modified by adding or removing machines. Two programs, which are dedicated to molecular modeling and were previously developed on single machines (OSIRIS and IMPALA), have been adapted. IMPALA models peptide and protein interaction with membranes, OSIRIS simulates an ab initio folding of globular proteins. After parallelization, each program consists of two parts: one is the human/RAMSES interface, and the second is the simulation per se. The parallel architecture is transparent for the users. Tests of the IMPALA and OSIRIS efficiencies are shown and discussed. [less ▲]

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See detailJe lis, j'écris : la pratique du journal de lecture
De Croix, Séverine ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2001), 50

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See detailRhabdomyolyse fatale sous cerivastatine.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(8), 592-4

Cerivastatin was recently withdrawn from the market after the report of more than 30 deaths in the United-States among patients receiving a combination of cerivastatin and gemfibrozil, a fibrate which is ... [more ▼]

Cerivastatin was recently withdrawn from the market after the report of more than 30 deaths in the United-States among patients receiving a combination of cerivastatin and gemfibrozil, a fibrate which is not anymore on the Belgian market. The cause of death was attributed to severe rhabdomyolysis. Cases were also reported among patients treated by cerivastatin only. Recommendations for better use of lipid-lowering drugs are given in order to optimize the benefit/risk ratio of such treatment. [less ▲]

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See detailAnaesthesia for laparoscopic surgery
Kaba, Abdourahmane ULg; Joris, Jean ULg

in Current Anaesthesia and Critical Care (2001), 12

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See detailTremblement essentiel: diagnostic différentiel et traitement
DELVAUX, Valérie ULg; MAERTENS DE NOORDHOUT, Alain ULg

in Médecine et Hygiène (2001), 59

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See detailOptimisation of Stiffened Structures
Rigo, Philippe ULg

in Dept. of Naval Architecture and Marine Engineering (2001)

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See detailExperimental and Theoretical Energy Levels, Transition probabilities and Radiative Lifetimes in Yb III
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Li, Z. S. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (2001), 34

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See detailComparison of inulin with urea as dilutional markers of bronchoalveolar lavage in healthy and heaves-affected horses.
Kirschvink, Nathalie; Fievez, Laurence ULg; Dogne, S. et al

in Veterinary Research (2001), 32(2), 145-154

Solute analysis in bronchoalveolar lavage fluid involves the use of dilutional markers to correct for variable recovery of pulmonary epithelial lining fluid (PELF). Urea is the best characterised ... [more ▼]

Solute analysis in bronchoalveolar lavage fluid involves the use of dilutional markers to correct for variable recovery of pulmonary epithelial lining fluid (PELF). Urea is the best characterised endogenous marker, whereas inulin appears to meet the requirements of an exogenous marker. In horses, the use of inulin has never been investigated and the impact of lower airway diseases such as heaves, on PELF recovery is unknown. In this study, five healthy and five heaves-affected horses underwent airway endoscopy and bronchoalveolar lavage. PELF recovery from bronchoalveolar lavage was calculated by the inulin and the urea method. The inulin method was compared to the urea method and differences between healthy and heaves-affected horses were analysed. From a technical and analytical point of view, inulin fulfilled the requirements of a marker of dilution as well as urea. When both healthy and heaves-affected horses groups were pooled together, PELF recovery calculated by the inulin method was significantly higher than by the urea method (6.43+/-4.08% versus 0.789+/-0.299%, P < 0.005). No significant differences were observed between healthy and heaves-affected horses, neither by the inulin nor by the urea method. Inulin did not present major advantages over urea, but the combined use of both markers can improve the standardisation of studies comparing PELF compounds, by providing upper limits (inulin dilution) and lower limits (urea dilution) of PELF recovery. [less ▲]

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See detailUnraveling Oligodendrocyte Origin and Function by Cell-Specific Transgenesis
Belachew, Shibeshih ULg; Yuan, Xiaoqing; Gallo, Vittorio

in Developmental Neuroscience (2001), 23(4-5), 287-98

Besides the role of mature oligodendrocytes in myelin synthesis during the development of the central nervous system (CNS), the oligodendrocyte lineage also encompasses the largest pool of postnatal ... [more ▼]

Besides the role of mature oligodendrocytes in myelin synthesis during the development of the central nervous system (CNS), the oligodendrocyte lineage also encompasses the largest pool of postnatal proliferating progenitors whose behavior in vivo remains broadly elusive in health and disease. We describe here transgenic models that allow us to track the functions and origins of such cells by using proteolipid protein and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) gene promoters to direct oligodendroglial expression of different reporters, in particular the green fluorescent protein (GFP). We emphasize that the CNP-GFP mouse, which targets the entire oligodendroglial lineage from embryonic life to adulthood, provides an outstanding tool to study the in vivo properties of oligodendrocyte progenitor cells in normal and damaged CNS. [less ▲]

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See detailRéflexions sur le sinistre protection juridique
Paris, Catherine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailLe martin-pêcheur (Alcedo atthis) va-t-il bientôt manquer de sites de nidification ?
Libois, Roland ULg

in Aves (2001), 38(4), 161-178

In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural ... [more ▼]

In south-west Belgium, the breeding of the kingfisher was monitored for more than 10 years. During this period, 158 banks were regularly surveyed. Alterations or potential threats were identified: natural erosion, cattle trampling, disturbance from kayak-riders or anglers and, last but not least, consolidation works. Only 56 banks (35.4 %) can de considered as "safe". However, since the recent (2001) legal restrictions about the navigation on small rivers, 12 more banks are now safe too. Cattle trampling appears as the main threat (55 sites). However, the enforcement of the law regulating the fences along the rivers could easily solve the problem. Nineteen banks were completely destroyed for different purposes: navigation, road retaining walls or simply anti-erosive measures. Most of these works were undertaken along the river Meuse, the best nidification habitat of the area. (11 photos) [less ▲]

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See detailLe tympan de l’Enfance du Christ à la cathédrale de Strasbourg (l’iconographie)
Van den Bossche, Benoît ULg

in Grenzenlos. Historische Zeitschrift der Erwin-von-Steinbach-Stiftung (2001), 14

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See detailObesity: causes and new treatments.
Lefebvre, Pierre ULg; Scheen, André ULg

in Experimental & Clinical Endocrinology & Diabetes (2001), 109 Suppl 2

The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors ... [more ▼]

The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors. Preventing obesity requires a major investment in nutritional and lifestyle education, particularly in children and adolescents.--The pharmacological approach to obesity includes drugs that reduce food intake (noradrenergic and serotoninergic agents), drugs that increase energy expenditure and compounds that affect nutrient partitioning. In all instances, the benefit-to-risk ratio needs to be carefully assessed. In some patients (severe obesity or obesity accompanied by serious high-risk comorbid conditions), gastric surgery (gastric restriction or gastric bypass) should be considered. In our own experience, it is safe and effective. [less ▲]

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See detailLa créance d'honoraires de l'avocat contre l'assureur protection juridique sous l'angle de la délégation
Paris, Catherine ULg

in Revue Générale des Assurances et des Responsabilités (2001)

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