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See detailHerpesvirus Of Turkeys Homologue Of Hsv Vp16 Is Structurally Related To Varicella Zoster Virus Trans-Inducing Protein Encoded By Orf 10
Kopacek, J.; Zelnik, V.; Brasseur, Robert ULg et al

in Virus Genes (1997), 15(1), 45-52

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and ... [more ▼]

Expression of the immediate-early genes of alpha-herpesviruses is stimulated by a family of trans-inducing factors represented by VP16 of HSV-1 and ORF10 gene product of VZV. We have identified and determined the nucleotide sequence of the UL48 gene encoding the herpesvirus of turkeys (HVT) homologue of HSV VP16. The gene maps to the BamHI-J fragment and appears to be expressed in a form of bicistronic transcript together with UL49. The deduced amino acid sequence of the protein encoded by HVT UL48 gene shows 55% identity with MDV UL48 gene product. Like the majority of related proteins in other alpha-herpesviruses, the protein encoded by HVT UL48 gene lacks the acidic C-terminal tail, known to possess the transactivation capacity of HSV VP16. Hydrophobic cluster analysis has revealed that its predicted domain composition is closely related to the transactivator protein encoded by ORF10 of VZV. However, the putative amino-terminal activation domain of the HVT homologue of HSV VP16 does not contain a typical horseshoe-like hydrophobic cluster found in other alpha-herpesvirus homologues, suggesting either that it acts as a transactivator via a different activation domain or that its transactivation potential is diminished. [less ▲]

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See detailPerspective in the treatment of insulin resistance.
Scheen, André ULg

in Human Reproduction (1997), 12 Suppl 1

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including ... [more ▼]

Improving the action of insulin is a relatively new concept in therapy. It should, however, become more and more important because of the rapid expansion of the insulin resistance syndrome (including upper body adiposity, glucose intolerance, hypertension, dyslipidaemia, etc.) in industrialized countries and its dramatic consequences for public health. Insulin sensitivity can be improved by non-pharmacological means, essentially reduction of excessive body weight, promotion of regular physical activity and modification of dietary habits, as well as, possibly, cessation of smoking and correction of subclinical magnesium deficiency. Currently available pharmacological means mainly include the biguanide compound metformin and possibly anti-obesity agents, such as (d-) fenfluramine, fluoxetine and benfluorex. New compounds aiming at improving the action of insulin are in development, especially the thiazolidinedione derivatives (e.g. troglitazone), known as 'insulin sensitizers'. Treatment of insulin resistance may have important gynaecological applications, essentially in polycystic ovary syndrome and, possibly, after menopause. Hopefully, improving insulin sensitivity could ameliorate the cardiovascular prognosis of numerous individuals having some or all components of insulin resistance syndrome. [less ▲]

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See detailZastosowanie ultrasonografii w diagnostyce klinicznej ukladu rozrodczego u bydla
Gajewski, Z.; Hanzen, Christian ULg; Thun, R. et al

in Nowa Weterynaria (1997)

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See detailRelationships of growth hormone gene and milk protein polymorphisms to milk production traits in Simmental cattle
Falaki, M.; Prandi, A.; Corradini, C. et al

in Journal of Dairy Research (1997), 64(1), 47-56

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to ... [more ▼]

The importance of milk proteins and the positive effect of administration of growth hormone (GH) on milk production, and the presence in some dairy cattle lines of greater GH concentrations prompted us to examine the presence of restriction fragment length polymorphism at the GH gene using the restriction enzyme TaqI and to investigate associations between this polymorphism in Simmental cows and bulls, as well as milk protein variants in Simmental cows, and milk production traits. Blood and milk were sampled from 279 Italian Simmental cows and semen was collected from 148 bulls of the same breed. Two fragment bands, denoted A and B, of 6200 and 5200 bp respectively, were examined and three patterns, AA, AB and BB, were found in both animal samples. All variants previously reported in other studies, for kappa, beta, and alpha(s1)-caseins, and beta-lactoglobulin, were found in the cows' samples. For the cows' samples, a BLUP (Best Linear Unbiased Predictor) analysis of results was performed using a REML (Restricted Maximum Likelihood) program and known heritabilities, whereas for bulls we have performed a General Linear Model analysis. The effect of GH gene polymorphism, using TaqI restriction enzyme, on milk production traits was not significant, but bulls of BB pattern had a higher breeding value for milk yield than AA bulls (P < 0.05). For the kappa-casein genotypic effects, cows of AB genotype gave milli with 1.53+/-0.70 g/kg less fat than cows of AA genotype. In addition, breeding values for milk protein content were significantly higher in BB bulls, with 0.87+/-0.32 and 0.71+/-0.34 g/kg more milk protein than AA and AB bulls respectively. Thus, our results revealed a GH gene polymorphism and indicated significant effects of milk protein polymorphisms on milk production traits in the Italian Simmental breed. [less ▲]

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailInfluence of whole milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats
Hornick, Jean-Luc ULg; Clinquart, Antoine ULg; Van Eenaeme, Christian ULg et al

in Livestock Production Science (1997), 48

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component ... [more ▼]

Influence of milk in diet of growing fattening Belgian Blue bulls on animal performances and on fatty acid composition in subcutaneous, intermuscular and intramuscular fats. The use of milk as component of a fattening diet for bulls was studied in an experiment carried-out over 2 years with Belgian Blue bulls. The animals weighed 305 kg at the beginning of the experiment. In all, 15 bulls were given a control concentrate fattening diet (control group, CG), while 11 others were fed concentrate plus 6.5 to 11 1 whole milk per day according to weight or age (milk group, MG). The fattening period lasted for 174 and 181 d respectively in groups CG and MG. The MG-group had a higher killing-out percentage (P < 0.01) and the meat was characterized by a lower b* value and a lower dry matter content (P < 0.1). Whole milk in the diet increased the proportion of shorter chain and saturated fatty acids in fat (P < 0.001) and reduced the proportion of mono- and polyunsaturated acids (P < 0.05; P < 0.1). The extent of the changes were larger in subcutaneous and intermuscular fats than in intramuscular fat. [less ▲]

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See detailA modification of convex approximation methods for structural optimization
Zhang, Wei-Hong; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 89-95

The most popular convex approximation methods used today in structural optimization are discussed in this paper: the convex linearization method (CONLIN), the method of the moving asymptotes (MMA) and the ... [more ▼]

The most popular convex approximation methods used today in structural optimization are discussed in this paper: the convex linearization method (CONLIN), the method of the moving asymptotes (MMA) and the sequential quadratic programming method (SQP). Modifications are made to enhance the reliability of the CONLIN method. In addition, a generalized MMA (GMMA) is established. However, in view of practical difficulties of evaluating second-order derivatives, a fitting scheme is proposed in this work to adjust the convexity of the approximation based on the available function value at the preceding design iteration. Numerical results show that this simple scheme is efficient in our applications. [less ▲]

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See detailLuteinizing hormone increases the abundance of various transcripts, independently of the androgens, in the rat prostate.
Reiter, E.; Poncin, Joseph ULg; Hennuy, Benoît ULg et al

in Biochemical and Biophysical Research Communications (1997), 233(1), 108-12

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult ... [more ▼]

Differential display analysis was carried out to find, in the rat prostate, genes that could be regulated by Luteinizing Hormone (LH), independently of the androgens. Hypophysectomized and castrated adult rats were treated with either LH, testosterone or saline. Regulated discrete bands have been eluted and reamplified. After Northern blotting, the levels of mRNA corresponding to 8 PCR fragments were significantly increased by LH treatment. None of these inserts were found to be induced by testosterone. One insert was subcloned, sequenced and identified as the ribosomial protein S 23. A competitive RT-PCR assay was carried out on the full length S 23 cDNA and confirmed that its mRNA levels were stimulated by LH but not by testosterone. These results strongly suggest that the LH membrane receptor, previously shown to be expressed in the rat prostate, has a physiological significance in this organ. Moreover, it appears that the effect of LH on the rat prostate are independent of the androgens. [less ▲]

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See detailTell Amarna 1997
Tunca, Önhan ULg

in Chronique archéologique en Syrie 2 (1997)

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See detailThe Burden of Hypopituitarism in Adults after Pituitary Surgery
Van Roijen, L.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in Journal of Clinical Endocrinology and Metabolism (1997), 4(Suppl. B), 139-142

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short ... [more ▼]

The burden of illness was assessed in 183 hypopituitary patients, with growth hormone deficiency, who had received pituitary surgery at the Centre Hospitalier Universitaire de Liège, Belgium. The Short-Form 36 (SF-36) was used to assess health status, and the Health and Labour Questionnaire was used to obtain data on production loss and reduced labout performance. Data on medical consumption were also collected. The overall response rate was 72 %. Hypopituitary patients reported a lower health status than that of the mean population in all but two dimensions of the SF-36 (bodily pain and physical functioning). A relativelu high percentage of hypopituitary patients reported being incapacitated for paid employment, and those in paid employment reported higher absence rates compared with reference data. However, while at work there was no indication that hypopituitary patients perform less well due to health problems than the average population. Healthcare costs for hypopituitary patients who had undergone pituitary surgery were higher than for the reference population. [less ▲]

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See detailQuality of life as outcome in the treatment of osteoporosis : The development of a questionnaire for quality of life by the European Foundation for Osteoporosis
Lips, P; Cooper, C; Agnusdei, D et al

in Osteoporosis International (1997), 7

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See detailDiagenetic and paleogeographic significance of clay and other sedimentary components in the middle Devonian limestones of Western Ardennes, France
Chamley, H.; Proust, J. N.; Mansy, J. L. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1997), 129

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at ... [more ▼]

Givetian deposits accumulated in a more than 300-m-thick succession on a carbonate platform developed on the passive margin of the so-called Rheic ocean. These rocks crop out in the Ardenne massif at Glageon in a structural context marked by small fault-controlled basins subjected to moderate overburden, tectonic and metamorphic constraints. Data on the clay mineral distribution, associated with detailed information on limestone facies/microfacies, as well as data on the depositional profile and sequence stratigraphic evolution of these rocks indicate strong carbonate diagenesis and moderate clay diagenesis, the latter being favoured by the early occurrence of the former, which prevented further fluid-rock interaction. The clay assemblage distribution, which roughly parallels the palaeomorphologic and palaeobathymetric shape of the Givetian continental margin, is organized in five successive zones indicating large-scale sequence stratigraphic evolution and the control of regional sea-level fluctuations. The clay and other sedimentary components provide additional information on the warm and variably humid climate, northern, relative to southern, terrigenous sources, the open sea relative to restricted depositional environments, the temporary tectonic rejuvenation of the continental hinterland and the chemical conditions allowing early diagenetic modifications. [less ▲]

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See detailEtablissement d'un plan volontaire de contrôle de la rhinotrachéite infectieuse bovine en région wallonne de Belgique
De Wergifosse, Bertrand; Lemaire, Mylène; Pastoret, Paul-Pierre ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailEvolution of coronary atherosclerosis in patients with mild coronary artery disease studied by serial quantitative coronary angiography at 2 and 4 years follow-up. The Multicenter Anti-Atheroma Study (MAAS) Investigators.
Vos, J.; de Feyter, P. J.; Kingma, J. H. et al

in European heart journal (1997), 18(7), 1081-9

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The ... [more ▼]

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHODS AND RESULTS: In 129 patients with mild coronary artery disease, but not on lipid-lowering medication, three coronary angiograms were made each 2 years apart. Nine hundred and sixty five angiographically diseased and non-diseased segments were analysed by quantitative coronary angiography. Mean lumen diameter and minimal lumen diameter were used as measures of diffuse and focal coronary atherosclerosis. Mean lumen diameter and minimum lumen diameter decreased by 0.02 and 0.03 mm per year. The rate of progression was similar in the angiographically non-diseased, as in the mildly and moderately diseased segments. Progression of diffuse coronary atherosclerosis was largest in severely stenosed lesions (percentage diameter stenosis > or = 50%) and in the right coronary artery with a loss of 0.19 mm and 0.16 mm in mean lumen diameter. Progression of focal disease was most prominent in new and mild lesions and the right coronary artery, with a decrease in minimum lumen diameter of 0.34 mm and 0.22 mm. In most subgroups, progression occurred gradually over time. On a per segment level, progression and the occurrence of new lesions occurred in 4.4% and 4.2%. Regression and disappearance of a lesions was found in 2.3% and 1.9%. On a per patient level, 36% were progressors, 12% had a mixed response, 36% were stable, and 16% were regressors. CONCLUSION: Diffuse and focal coronary atherosclerosis progressed at the same rate in the first and second 2 years in stenosed and non-stenosed segments. The rate of coronary atherosclerosis progression was small, but was higher for focal than for diffuse disease. A minority of lesions progressed and spontaneous regression was rare. [less ▲]

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See detailMeasurements of the ground state ionization energy and wavelengths for the 1snp1P1 - 1s2 1S0(n=4-10) lines of O VII
Bartnik, A.; Biémont, Emile ULg; Dyakin, V. M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1997), 30

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailL’arsénopyrite du Massif de Stavelot, Belgique
Hatert, Frédéric ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66

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See detailCharacterization of Clostridium perfringens isolates from goats.
Phukan, A.; Dutta, G.-N.; Daube, Georges ULg et al

in Indian Veterinary Journal (The) (1997), 74

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See detailPresbyphonia voice differencies between the secties in the elderly. comparison by maximum phonation time, phonation quotient and spectral analysis
Morsomme, Dominique ULg; Jamart, Jacques; Boucquey, Donatienne et al

in Logopedics, Phoniatrics, Vocology (1997), 22

This study of 40 elderly subjects (30 women and 10 men) between the ages of 70 to 90, attempts to qualify and quantify their voices and to compare the results with a young population and to establish any ... [more ▼]

This study of 40 elderly subjects (30 women and 10 men) between the ages of 70 to 90, attempts to qualify and quantify their voices and to compare the results with a young population and to establish any differences between the two sexes. The measurements concerned the Vital Capacity (VC), the Maximum Phonation Time (MPT) and the Phonation Quotient (PQ). The equivalent values for a young population were compiled from the literature. Spectral voice analysis was also included in the study. The mean speaking fundamental frequency (Fo) of the voice changes with age; it increases in men and decreases in women (158 Hz in elderly men vs a normal value of 120 Hz; 205 Hz in elderly women vs a normal value of 225 Hz). Ageing influences the vital capacity to the advantage of men (median VC = 2.61 vs 1.61 in elderly men and women, respectively). For sustaining a vowel a, the Maximum Phonation Time (MPT) is significantly better in elderly men (median MPT = 16 sec in elderly men and 12 sec for women). Phonation Quotient does not differ significantly between sexes (median PQ = 153 ml/sec in elderly men and 152 ml/sec in elderly women). Although, the physical capacity of elderly women decreases, their vocal output remains very good when compared to young women. In elderly men, however, there is a phonation quotient decrease of 25 per cent compared to young men. [less ▲]

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See detailEffect of diet and bST on mRNA for IGF-I binding proteins (BP)-2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in Journal of Dairy Science (1997), 80(suppl 1), 176

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See detailAlteration of radiation response in vitro by simultaneous modulation of the de novo and salvage pathways to deoxynucleoside triphosphate pool by (E)-2′-Deoxy-(Fluoromethylene)cytidine and thymidine analogs
Coucke, Philippe ULg; Li, Ye-Xiong; Cottin, Eliane et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (supp1)), 257

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See detailIA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.
Gorus, F. K.; Goubert, P.; Semakula, C. et al

in Diabetologia (1997), 40(1), 95-9

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody ... [more ▼]

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody (IA-2-Ab) assay in 474 IDDM patients and 482 non-diabetic control subjects aged 0-3 years. IA-2-Ab were detected in 58% of the patients and 0.8% of control subjects. Their prevalence in patients was lower than that of islet cell autoantibodies (ICA; 73%) or glutamic acid decarboxylase (M(r) 65 kDa)-autoantibodies (GAD65-Ab; 82%) but higher than that of insulin autoantibodies (IAA; 42%). IA-2-Ab were more frequent in patients under age 20 years (70%) than between 20 and 40 years (45%; p < 0.001). In the whole IDDM group, 92% of patients were positive for at least one of the three molecular assays, which is higher than the positivity for the ICA assay (73%). Only 1% was negative in the molecular assays and positive in the ICA assay. IA-2-Ab levels were positively correlated with ICA titres (p < 0.001) and HLA DQ A1*0301-DQ B1*0.02 (p < 0.003) by multivariate analysis. In a group of 481 non-diabetic siblings (age 0-39 years) of IDDM patients only 7 were IA-2-Ab positive (1.5%). All seven were under age 20 years and positive for at least two other autoantibodies and for DQ A1*0301-DQB1*0302. Four of these seven developed IDDM during the 6-70-month follow-up period. The positive predictive value of IA-2-Ab (57%) was higher than that of ICA, GAD65-Ab or IAA alone, or in combination (< or = 20%) but these calculations are restricted by the relatively short observation period and the small number of cases. The only IA-2-Ab-negative case of pre-diabetes was also negative for IAA and GAD65-Ab, while it was strongly positive for ICA. In conclusion, IA-2-Ab show a high diagnostic specificity for IDDM and are predictive markers of impending diabetes in siblings of patients. In combination with other molecular antibody assays they may replace ICA testing in future. Our data also indicate that other autoantibodies than IA-2-Ab, GAD65-Ab and IAA contribute to ICA. [less ▲]

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See detailEvidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Louis, Renaud ULg; Shute, J.; Biaggi, S. et al

in American Journal of Respiratory & Critical Care Medicine (1997), 155(2), 466-472

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma ... [more ▼]

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects contained increased numbers of eosinophils and levels of eosinophil cationic protein (ECP) and mast cell tryptase. Eosinophil numbers, and ECP and histamine levels correlated with the degree of methacholine airways responsiveness, and ECP, tryptase, and histamine correlated with raised concentrations of albumin. Using the micro-Boyden chamber technique eosinophil chemotactic activity was identified only in the sputum from asthmatics. The correlation between the raised levels of total IgA, IL- 8/IgA complexes, and tryptase and the degree of sputum eosinophilia and ECP levels, suggests possible mechanisms for eosinophil chemotaxis and activation in asthma. Row cytometric analysis of sputum lymphocytes showed an increase in CD4+ T cells and T cells expressing intercellular adhesion molecule-1 (ICAM-1) in asthma which, together with the finding of raised levels of soluble ICAM-1 in the sputum, indicates upregulation of this adhesion molecule. Finally, the proportion of CD16+ natural killer (NK) cells was reduced in the sputum of asthmatics. These observations highlight the importance of the airway inflammation in causing asthma and further confirm the usefulness of sputum induction as a tool in asthma research. [less ▲]

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See detailA global model of the biosphere : validation and applications to present and past climatic conditions
François, Louis ULg; Gérard, Jean-Claude ULg; Nemry, Bernard et al

in Sciences Géologiques. Bulletin (1997), 50(1-4), 89-107

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See detailThe Photoabsorption Spectrum of Vinylchloride (C2H3Cl) in the 8-12 eV Range.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg ... [more ▼]

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg transitions have been identified and classified. Tentative assignments were based on the ionization energies as measured by He(I)- and threshold photoelectron spectroscopy, as reported in the joined paper. Many features have been identified as being members of vibrational progressions belonging to the observed Rydberg series. [less ▲]

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See detailEuroback : Goals and achievement after one year
Jérome, Simone; Thirion, Paul ULg

in Serials Review (1997), 23(1), 53-56

EUROBACK is but a European clone of BackServ. It was launched because those who conceived it had a positive experience with the American-based electronic list. This article will explore why EUROBACK is ... [more ▼]

EUROBACK is but a European clone of BackServ. It was launched because those who conceived it had a positive experience with the American-based electronic list. This article will explore why EUROBACK is necessary as a separate list, and it will compare librarianship on the North American and European continents, where library materials are viewed quite differently. [less ▲]

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See detailAllozyme diversity and genetic structure in South - Western populations of Heather, Calluna vulgaris (L.) Hull
Mahy, Grégory ULg; Vekemans, Xavier; Jacquemart, Anne Laure et al

in New Phytologist (1997), 137

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See detailComplexation of uranyl ion by polyvinylimidazole: Electrochemical preparation and leaching tests investigations
Martinot, Lucien; Leroy, D.; Jérôme, Christine ULg et al

in Journal of Radioanalytical & Nuclear Chemistry (1997), 224(1-2), 71-76

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical ... [more ▼]

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical preparation of polyvinylimidazole (PVI) which is a polymer capable of complexing uranyl ions. We confirm the complexation of uranyl ions by PVI in various media by FT-IR and UV-Visible analysis but all these complexes were found to be soluble in water so we put forward new complexes with an additional polymer to shape out insoluble complex. Leaching tests demonstrate the efficiency of our process. [less ▲]

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See detailGénération innommable
Demoulin, Laurent ULg

in Textyles : Revue des Lettres Belges de Langue Française (1997), 14

Evocation de tendances romanesque ayant émergé dans les années 1980 et 1990 envisagées au moyen des notions discutables et discutées de "minimalisme" et de "postmodernité".

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See detailSaint Lambert à Voroux-Goreux. L'ancienne statue du saint patron retrouvée ?
Marganne, Marie-Hélène ULg; Mélard, Marc

in Bulletin de la Société Royale Le Vieux-Liège (1997), 277

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See detailThe Major Homology Region Of Bovine Leukaemia Virus P24(Gag) Is Required For Virus Infectivity In Vivo
Willems, Luc ULg; Kerkhofs, P.; Attenelle, L. et al

in Journal of General Virology (1997), 78

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See detailRegolazione della crescité follicolare e luteinica. Folliculogenesi e atresia. Summa.
Drion, Pierre ULg; Beckers, Jean-François ULg; Ectors, Fabien ULg et al

in Summa (1997), 14(9), 5-16

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for ... [more ▼]

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for follicular recruiment. The recruited follicles produce estradiol, inhibin and follistatin which reduce the FSH secretion (negative feed back) reducing their support to hormonodependant follicles which become atresic. The dominant follicle, subjected to internal self stimulation is not sensitive to the reduction in FSH levels and carries on synthesising more and more estradiol. [less ▲]

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See detailImproved emulsifying and foaming of whey proteins after enzymic fat hydrolysis
Blecker, Christophe ULg; Paquot, Michel ULg; Lamberti, I. et al

in Journal of Food Science (1997), 62(1), 48-

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This ... [more ▼]

In an effort to improve emulsifying and foaming of sweet whey and whey protein concentrate, we studied the hydrolysis of the residual fat in these preparations with a sn 1,3 specific lipase. This enzymatic lipolysis would convert almost all triglycerides into mono- and diglycerides which have strong surface-active properties. Therefore, the emulsifying and foaming capacities of such modified whey products should be increased in comparison with native products, as shown by results presented at both neutral pH and those similar to a salad dressing emulsion. It was also demonstrated that emulsions and foams formed with lipase-treated whey preparations were more shelf-stable. [less ▲]

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See detailStructural And Functional Properties Of The 154-171 Wild-Type And Variant Peptides Of Human Lecithin-Cholesterol Acyltransferase
Peelman, F.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 249(3), 708-15

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment ... [more ▼]

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment and its orientation at a lipid/water interface are similar to those of some of the helical repeats of apolipoprotein A-IV and E. This domain was therefore proposed as a candidate peptide accounting for the association between LCAT and its lipid substrate. To investigate this hypothesis we synthesized the LCAT-(154-171)-peptide, two variants containing the natural Y156N and R158C mutations and a variant with increased hydrophobicity through Y156I, L160I, L163I and Y171W substitutions. The structural and lipid-binding properties of these synthetic peptides were investigated by turbidity, fluorescence, electron microscopy and circular dichroism. The wild-type peptide, the R158C variant in its dimeric form, as well as the more hydrophobic peptide, associated with phospholipids, whereas the Y156N and the R158C variant in its monomeric form did not. However, only the complexes generated with the hydrophobic variant were stable enough to resist dissociation during gel filtration. The wild-type peptide and hydrophobic variant formed discoidal complexes with dimyristoylglycerophosphocholine (Myr2GroPCho) as shown by negative staining electron microscopy. Comparison of the properties of the wild-type and hydrophobic variant LCAT-(154-171)-peptide stresses the contribution of the hydrophobic face of the amphipathic helix to the formation and stabilization of the peptide/lipid complexes. This is further confirmed by the decreased affinity of the Y156N variant peptide for lipids, as this mutation decreased the mean hydrophobicity of the hydrophobic face of the amphipathic helix. These results support the hypothesis that the 154-171 segment of LCAT might be involved in the interaction of the enzyme with its lipid substrate and suggest that the decreased activity of the Y156N natural LCAT mutant might result from a decreased affinity of this mutant for lipids. [less ▲]

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See detailTricho-hepato-enteric syndrome: further delineation of a distinct syndrome with neonatal hemochromatosis phenotype, intractable diarrhea, and hair anomalies.
Verloes, A.; Lombet, J.; Lambert, Yves ULg et al

in American Journal of Medical Genetics (1997), 68(4), 391-5

We report on two sibs with syndromal congenital iron storage disease. Prenatal symptoms were IUGR, hydramnios, and placental hyperplasia. Clinical anomalies included hypertelorism and sparse, thin, curly ... [more ▼]

We report on two sibs with syndromal congenital iron storage disease. Prenatal symptoms were IUGR, hydramnios, and placental hyperplasia. Clinical anomalies included hypertelorism and sparse, thin, curly hair (trichomalacia). Clinical course was marked by intractable diarrhoea, with normal histological and enzymological studies, cholestatic jaundice, hepatomegaly appearing after 30 days, and progressive liver failure, leading to death after a few months. The only metabolic anomaly was progressive hypermethioninemia. Pathologic examination of both children showed a similar pattern of multivisceral iron deposit compatible with a diagnosis of neonatal hemochromatosis: extensive liver fibrosis or cirrhosis with nodular regeneration, cholestasis, ductular proliferation, and hepatic, pituitary, thyroidal, adrenal, and pancreatic iron deposition. The unusual course for neonatal hemochromatosis in both sibs combined with concordant extrahepatic anomalies suggest that they could have a specific iron storage syndrome with possible autosomal recessive inheritance, probably similar to the sibship reported by Stanckler et al. [Arch Dis Child, 57:212-216, 1982]. [less ▲]

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See detailComparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood.
Sautois, Brieuc ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Experimental hematology (1997), 25(2), 103-8

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host ... [more ▼]

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host disease (aGVHD), a major life-threatening complication of allo-transplantation. The physiopathology of aGVHD implies the recognition of host alloantigens by donor T cells but also involves a cytokine cascade. In this cascade, interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) produced by donor T cells and monocytes/macrophages play a major effector role. Therefore, we investigated whether the lower percentage of aGVHD in cord blood transplants could be related to a lower ability to produce these cytokines in vitro compared with adult blood. Mononucleated cells (MNCs) isolated from term cord blood and adult peripheral blood were stimulated with a combination of lipopolysaccharide and phytohemaglutinin and incubated for 96 hours. Levels of IL-1beta, IL-2, IL-3, IL-4, IL-6, TNF-alpha, IFN-gamma, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in the supernatants after various times of incubation. The productions of IL-1beta, IL-6, and GM-CSF were similar in stimulated cord and adult blood and IL-3 levels, though lower and delayed in cord blood, were not statistically different. On the other hand, we found markedly lower levels of IFN-gamma, TNF-alpha, and IL-4 in cord blood throughout the incubation period. The stimulated levels of IL-2 were similar in cord and adult samples throughout the first 48 hours of incubation but became significantly lower in cord blood after 72 and 96 hours. We suggest that the cytokine production pattern that characterizes cord blood could provide an explanation for the lower occurence of aGVHD following cord blood transplants. [less ▲]

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See detailPropriétés des profils de flux d'induction magnétique dans les céramiques supraconductrices
Vanderbemden, Philippe ULg

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1997), 2

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See detailVaccinia virus immune evasion
Smith, G. L.; Symons, J. A.; Khanna, A. et al

in Immunological Reviews (1997), 159

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include ... [more ▼]

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines. [less ▲]

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See detailTwo centuries of vaccination
Vanderplasschen, Alain ULg; Smith, G. L.

in Annales de Médecine Vétérinaire (1997), 141

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See detailThe role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids.
El Ouahabi, A.; Thiry, Marc ULg; Pector, V. et al

in FEBS Letters (1997), 414(2), 187-92

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three ... [more ▼]

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three following cationic compounds: [1] vectamidine (3-tetradecylamino-N-tert-butyl-N'-tetradecylpropionamidine, and previously described as diC14-amidine [1]), [2] lipofectin (a 1:1 mixture of N-(1-2,3-dioleyloxypropyl)-N,N,N-triethylammonium (DOTMA) and dioleylphosphatidylethanolamine (DOPE)), and [3] DMRIE-C (a 1:1 mixture of N-[1-(2,3-dimyristyloxy)propyl]-N,N-dimethyl-N-(2-hydroxyethyl) ammonium bromide (DMRIE) and cholesterol). Surprisingly, a high CAT activity was observed with vectamidine although the DNA uptake efficiency was lower as compared to lipofectin and DMRIE-C. Transmission electron microscopy (TEM) revealed endocytosis as the major pathway of DNA-cationic lipid complex entry into COS cells for the three cationic lipids. However, the endosomal membrane in contact with complexes containing vectamidine or DMRIE-C often exhibited a disrupted morphology. This disruption of endosomes was much less frequently observed with the DNA-lipofectin complexes. This comparison of the three compounds demonstrate that efficient transfection mediated by cationic lipids is not only correlated to their percentage of uptake but also to their ability to destabilize and escape from endosomes. [less ▲]

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See detailLa survie des savoirs médiévaux dans la littérature populaire. Le rôle des incunables
Opsomer, Carmélia ULg

in Bulletin de la Société des Bibliophiles liégeois (1997), 23

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See detailLes différents vaccins disponibles contre la rhinotrachéite infectieuse bovine
Thiry, Etienne ULg; Lemaire, Mylène; Schynts, Frédéric et al

in Bulletin des Groupements Techniques Vétérinaires (1997), 4B

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See detailDopamine 'D2-like' receptor agonists in combination with cocaine: absence of interactive effects on locomotor activity.
Tirelli, Ezio ULg; Reggers, Jean ULg; Terry, P.

in Behavioural Pharmacology (1997), 8(2-3), 147-59

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in ... [more ▼]

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measured by photobeam crossings over 140 min. At the doses given (7-OH-DPAT: 0.006-6.4 mg/kg; quinpirole: 0.001-1 mg/kg; RU24213: 0.008-8 mg/kg) all three direct agonists dose-dependently reduced locomotor activity throughout the test, whereas cocaine (0.6-20 mg/kg) produced dose-related hyperactivity. Next, for each direct agonist, a series of doses was selected (up to threshold behaviourally-active doses) as pretreatments to a sub-maximally stimulant dose of cocaine (15 mg/kg). 7-OH-DPAT and quinpirole did not modulate the effects of cocaine; RU24213 produced, at best, a very modest attenuation of the effects of cocaine. Finally, a series of cocaine doses (below stimulant threshold) was given before a single dose of each direct agonist (the lowest dose to reduce activity significantly). Cocaine did not reliably alter the hypoactivity produced by any of the D2-like agonists. By demonstrating negligible interactions between cocaine and D2-like agonists, the results fail to demonstrate any necessary involvement of D2-like receptors in one of the behavioural effects of cocaine. [less ▲]

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See detailRegular compactly supported wavelets in Sobolev spaces
Bastin, Françoise ULg; Laubin, P.

in Duke Mathematical Journal (1997), 87(3), 481-508

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See detailAntisense galectin-3 alters thymidine incorporation in human MDA-MB435 breast cancer cells
van den Brûle, Frédéric; Bellahcene, Akeila ULg; Jackers, Pascale ULg et al

in International Journal of Oncology (1997), 11(2), 261-264

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See detailMechanisms of cancer-related anemia and rationale for erythropoietin treatment
Beguin, Yves ULg

in Cancer Biotherapy (1997), 1

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See detailCalibration of a finite element model for bolted endplate steel connections
Bursi, O.; Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (1997), 44(No 3), 225-262

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See detailESRA guidelines for the use of epidural opioids
Aguilar, J. L.; Benhamou, D.; Bonnet, F. et al

in International Monitor on Regional Anaesthesia (1997), 9

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See detailPalladium-silver sol-gel catalysts for selective hydrodechlorination of 1,2-dichloroethane into ethylene - I. Synthesis and characterization
Heinrichs, Benoît ULg; Delhez, Patrice; Schoebrechts, Jean-Paul et al

in Journal of Catalysis (1997), 172(2), 322-335

Low-density xerogel Pd-Ag/SiO2 catalysts were prepared by a cogelation of tetraethoxysilane with organically substituted alkoxides capable of forming chelates with palladium and silver ions, followed by a ... [more ▼]

Low-density xerogel Pd-Ag/SiO2 catalysts were prepared by a cogelation of tetraethoxysilane with organically substituted alkoxides capable of forming chelates with palladium and silver ions, followed by a drying under vacuum, a calcination, and a reduction. The resulting Pd-Ag alloy particles have diameters of about 2-3 nm and are dispersed inside the silica particles which exhibit a monodisperse micropore size distribution centered at 0.8 nm. At low silver loading, the composition of the bimetallic particles is almost identical to the overall composition, but when this loading is increased, the percentage of silver in the alloy particles is appreciably lower than the overall percentage, In all bimetallic samples, a few large pure silver particles are observed. When dried under vacuum, the xerogels exhibit a texture similar to that of aerogels dried under supercritical conditions with pore volumes in the range 2-6 cm(3)/g and pores ranging from micro- to macropores of several hundred nanometers. When the silver loading is increased, xerogels containing palladium show aggregates of increasingly interpenetrated silica particles. This is explained bq an aggregation, during the gelation reaction, of colliding SiO2 particles which is limited by an increasingly slow sticking reaction due to the growing basicity in the precursor solution when the concentrations of Ag and associated compounds are increased. During thermal treatments, the Pd-Ag alloy seems to form by the migration, through the porous network, of silver which finally alloys with Pd crystallites trapped inside SiO2 particles. Whereas ethane is the main product when hydrodechlorination of 1,2-dichloroethane is performed over pure palladium, the dilution of this active metal by silver leads to a strong increase in ethylene selectivity. (C) 1997 Academic Press. [less ▲]

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See detailHair follicle involvement in herpes zoster
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Virchows Archiv : An International Journal of Pathology (1997), 430

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See detailQuelques données inédites sur l'accroissement des peuplements de hêtre en Région wallonne.
Rondeux, Jacques ULg; Lecomte, H.; Florkin, P. et al

in Silva Belgica (1997), 104(5), 7-14

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See detailEffect of beef type, body weight and dietary protein content on voluntary feed intake, digestibility, blood and urine metabolites and nitrogen retention
Fiems, Leo; Cottyn, B. G.; Boucqué, Charly et al

in Journal of Animal Physiology & Animal Nutrition (1997), 77

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See detailLecture critique d’un essai thérapeutique
Reginster, Jean-Yves ULg

in Revue du Rhumatisme (1997), 64(3), 84-86

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See detailDes auteurs dans les ruines. Parcours arbitraire
Delhalle, Nancy ULg

in Alternatives Théâtrales (1997)

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See detailFatal Mural Endocarditis and Cutaneous Botryomycosis after Heart Transplantation
Defraigne, Jean-Olivier ULg; Demoulin, J. C.; Pierard, Gérald ULg et al

in American Journal of Dermatopathology (1997), 19(6), 602-5

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a ... [more ▼]

Fatal mural endocarditis and botryomycosis occurred concurrently in a 62-year-old women 4 months after orthotopic heart transplantation. Subsequent to mild mitral regurgitation, infection developed on a left atrial thrombus and was complicated by cerebral embolization. Simultaneously, skin nodules manifested on both forearms. Histologic examination revealed typical aspects of early evolving botryomycosis with massive infiltration of the dermis and hypodermis by necrotic granulomas framed by grains of Gram-positive coccoid forms. Bacteria were decorated by a nonspecific polyclonal antibody to Mycobacterium bovis. [less ▲]

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See detailA 2-year phase II study with 1-year of follow-up of risedronate (NE58095) in postmenopausal osteoporosis
Clemmesen, B; Ravn, P; Zegels, Brigitte ULg et al

in Osteoporosis International (1997), 7

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See detailMulticité. Le jeu du développement urbain
Beckers, Jacqueline ULg; Demeuse, Yves; Merenne-Schoumaker, Bernadette ULg et al

in G.E.O. (1997), 41(Numéro spécial),

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la ... [more ▼]

Une équipe municipale doit définir le devenir de sa cité et gérer une série de projets (écoles, multiplex, logements sociaux, parcs industriels) avec comme consigne la minimisation des coûts pour la maximisation des retombées pour la collectivité ; elle fait appel à des bureaux d’études qui doivent monter ces projets. Le jeu se joue sur un territoire (plateau de jeu) avec ses quartiers d’habitat, son centre, ses réseaux de communication et aussi 350 îlots colorés selon l’affectation du sol et leur statut (public et privé). Le jeu – qui se déroule aussi sur deux fois 50 minutes dans sa version courte (un projet) – permet d’abord à l’équipe municipale de définir ses critères de choix et aux bureaux d’étude de monter leur projet, il met ensuite les protagonistes en contact puis en débat avant le choix final. Outre le plateau figurant le territoire, le jeu comprend encore des fiches relatives aux équipements, des consignes particulières pour les membres du bureau d’études et de l’équipe municipale (dont une fiche budget et une fiche argumentaire). À l’issue du jeu, il est possible non seulement de mettre en évidence les facteurs de localisation des équipements mais également le jeu des acteurs et les contraintes d’une politique de développement communal. [less ▲]

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See detailLa responsabilité pénale du réviseur d'entreprises : Épée de Damoclès ou Tigre de papier ?
Thirion, Nicolas ULg; Benoit-Moury, Anne

in Revue pratique des sociétés (1997), (2), 189-229

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See detailHuman follicular dendritic cells in vitro and follicular dendritic-cell-like cells.
Tsunoda, R.; Bosseloir, A.; Onozaki, K. et al

in Cell & Tissue Research (1997), 288(2), 381-9

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The ... [more ▼]

Human follicular dendritic cell (FDC)-like cells (FLC) have been utilized for the in vitro analysis of germinal center reactions. However, there is no consensus whether FLC represent FDC in vitro. The purpose of the present study has therefore been to determine distinguishing features of FDC and FLC in vitro. The expression of CD40, CD54, CD49d, cytokine (gamma-IFN and IL-4)-dependent MHC-class II, and CD106 was observed to be specific for the determination of FDC in long-term culture. The cytokine-dependent emperipolesis of germinal center B cells was establised as another discriminating property for FDC in vitro. In 2 out of 72 long-term cultures of FDC, we encountered dividing cells among the non-dividing population of FDC. The dividing cells expressed accessory molecules similar to those of FDC but showed emperipolesis only for the initial few days of their growth. FDC did not enhance the CD40-dependent proliferation of germinal center B cells; in contrast, FLC augumented it. Both types of cells produced a significant amount of cytokine-dependent IL-6. Further studies are needed to determine whether FLC originate from FDC in vitro. [less ▲]

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See detailEvolution des populations du tétras lyre Tetrao tetrix L. en Europe: un essai de synthèse
Loneux, Michèle ULg; Ruwet, Jean-Claude

in Cahiers d'Ethologie (1997), 17((2-3-4)), 287-343

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See detailClinical PET in oncology
Rigo, P.; Paulus, P.; Bury, Thierry ULg et al

in Radioactive Isotopes in Clinical Medicine Research XXII (1997)

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See detailZur Wortgeographie der Rheinlande. Über ein dialektologisches Projekt EDV-gestützter Wortkartenanalyse
Lausberg, Helmut; Möller, Robert ULg

in Berichte zur Deutschen Landeskunde (1997), 71

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See detailThe Civility of Relationships: Charles Tomlinson and the Conversion of American Modernism
Delville, Michel ULg

in Symbiosis: A Journal of Anglo-American Literary Relations (1997)

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See detailDe l’acyclovir au valacyclovir: la biodisponibilité en plus de l’efficacité et de la tolérance
Rentier, Bernard ULg

in Virologics (1997), (Septembre), 10-11

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See detailSoil Solution Nitrogen and Cations Influenced by (NH4)2SO4 Deposition in a Coniferous Forest
Carnol, Monique ULg; Ineson, Phil; Dickinson, A. L.

in Environmental Pollution (1997), 97(1-2), 1-10

The effects of chronically enhanced (NH(4))(2)SO(4) deposition on ion concentrations in soil solution and ionic fluxes were investigated in a Picea abies plot at Grizedale forest, NW England. Soil cores ... [more ▼]

The effects of chronically enhanced (NH(4))(2)SO(4) deposition on ion concentrations in soil solution and ionic fluxes were investigated in a Picea abies plot at Grizedale forest, NW England. Soil cores closed at the base and containing a ceramic suction cup sampler were 'roofed' and watered every 2 weeks with bulk throughfall collected in the field. Treatments consisted of the inclusion of living roots from mature trees in the lysimeters and increasing (NH(4))(2)SO(4) deposition (NS treatment) to ambient + 75 kg N ha(-1) a(-1). Rainfall, throughfall and soil solutions were collected every 2 weeks during 18 months, and analysed for major cations and anions. NO(3)(-) fluxes significantly increased following NS treatment, and were balanced by increased Al(3+) losses. Increased SO(4)(2-) concentrations played a minor role in controlling soil solution cation concentrations. The soil exchange complex was dominated by Al and, during the experimental period, cores of all treatments 'switched' from Ca(2+) to Al(3+) leaching, leading to mean [Formula: see text] molar ratios in soil solution of NS treated cores of 0.24. The experiment confirmed that the most sensitive soils to acidification (through deposition or changing environmental conditions) are those with low base saturation, and with a pH in the lower Ca, or Al buffer ranges. [less ▲]

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See detailMéthodes chromatographiques de dosage dans les milieux biologiques : stratégie de validation - Rapport d'une commission SFSTP
Chapuzet, E.; Mercier, N.; Bervoas-Martin, S. et al

in STP Pharma Pratiques (1997), 7(3), 169-194

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See detailMethodology for optimization of operation to reduce site-scale energy use in production plants
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Applied Thermal Engineering (1997), 17(8-10), 1005-1014

A methodology was developed to improve energy usage in the process industries by optimizing plant operation. The first step was to build fine tuned site-scale models of energy intensive production plants ... [more ▼]

A methodology was developed to improve energy usage in the process industries by optimizing plant operation. The first step was to build fine tuned site-scale models of energy intensive production plants and of combined heat and power utility distribution networks (heat, power, cooling), and later to optimize them using various numerical techniques. The methodology not only comprises these models, but also the selected optimization methods, their implementation in algorithms suited for the problems to be solved and the evaluation of the results in terms of their applicability ia real industrial problems. The detailed models were tuned on the basis of actual plant data. They were used to calculate accurate energy balances, and thus to identify sources of energy waste. Finally they allowed optimization of energy usage by adjusting operating conditions at a medium time scale (a few hours to a couple of days). Energy savings in the range 5%-10% could be obtained for energy intensive processes, where even a low percentage represents a considerable amount. (C) European Communities 1997. Published by Elsevier Science Ltd. [less ▲]

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See detailIsolation, identification and serotyping of Clostridium perfringens from goats.
Phukan, A.; Dutta, G. N.; Daube, Georges ULg et al

in Indian Journal of Animal Sciences (The) (1997), 67

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See detailThe two beta-lactamase genes of Streptomyces cacaoi, blaL and blaU, are under the control of the same regulatory system.
Magdalena, J; Gérard, Christine; Joris, Bernard ULg et al

in Molecular & General Genetics [=MGG] (1997), 255(2), 187-93

The production of beta-lactamase in Streptomyces cacaoi, which contains two beta-lactamase-encoding genes, blaL and blaU, is inducible by beta-lactam compounds. The two genes have been cloned ... [more ▼]

The production of beta-lactamase in Streptomyces cacaoi, which contains two beta-lactamase-encoding genes, blaL and blaU, is inducible by beta-lactam compounds. The two genes have been cloned independently in S. lividans TK24, a beta-lactamase-negative species. The blaU clone did not respond to the presence of beta-lactams, whereas the blaL clone appeared to be inducible in S. lividans. The latter clone contains two open reading frames, blaA and blaB, located just upstream of but transcribed divergently from blaL, which were shown to be required for the production as well as the induction of BlaL. The deduced BlaA protein belongs to the LysR family of transcription regulators. In order to examine the role of BlaA in regulation, we here report on over-expression of a GST-BlaA fusion protein in Escherichia coli and its use for antibody preparation. The GST-BlaA fusion protein was partially purified and bandshift assays showed that it bound the 197-bp blaL-blaA intergenic region. The BlaA DNA binding-site was further restricted to a 30-bp sequence containing a T-N11-A motif, a characteristic of LysR-type promoters. Another T-N11-A motif upstream of the blaU gene was also shown to bind BlaA. The affinities of these two T-N11-A motifs in BlaA binding were comparable. A plasmid bearing the blaU structural gene and the blaA-blaB regulatory region was constructed and shown to confer on an S. lividans host the capacity to produce inducible beta-lactamase. It can thus be concluded that the S. cacaoi blaL and blaU genes are controlled by the same regulatory system. [less ▲]

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See detailReprésentation de l'espace ouvert dans un système d'information de projet urbain
Dupagne, A.; Teller, Jacques ULg

in Ingénierie des Systèmes d'Information (1997), 5(2), 219-240

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See detailTechnique for long-term catheterization of large abdominal vessels in growing cattle.
Hornick, Jean-Luc ULg; Istasse, Louis ULg

in Contemporary Topics in Laboratory Animal Science (1997), 36(2), 66-8

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See detailLa tertiarisation des parcs d’activités économiques en Région wallonne
Devillet, Guénaël ULg

in Wallonie (1997), 24(49), 35-44

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See detailEtat de nécessité et damnum incendii arcendi causa datum
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (1997), 44

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See detailPhylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae.
Elmoualij, Benaïssa ULg; Duyckaerts, Claire ULg; Brasseur, Josette ULg et al

in Yeast (Chichester, England) (1997), 13(6), 573-581

The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be ... [more ▼]

The screening of the open reading frames identified in the whole yeast genome has allowed us to discover 34 proteins belonging to the mitochondrial carrier family. By phylogenetic study, they can be divided into 27 subfamilies including ADP/ATP, phosphate and citrate carriers, putative oxoglutarate and GDC carriers and 22 new subfamilies. Topology predictions using the 'positive inside rule' approach have shown that the yeast carriers are similarly oriented with both extremities exposed to the cytosol. In each subfamily, a strict conservation of the charged residues in the six transmembrane alpha-helices is observed, suggesting a functional role for these residues and the existence of 27 functionally distinct carriers. [less ▲]

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See detailEnhancement of Tamoxifen-Induced E-Cadherin Function by Ca2+ Channel Antagonists in Human Breast Cancer Mcf7/6 Cells
Charlier, Corinne ULg; Bruyneel, E.; Lechanteur, Chantal ULg et al

in European Journal of Pharmacology (1996), 317(2-3), 413-6

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to ... [more ▼]

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to restore the E-cadherin function of human breast cancer MCF7/6 cells and to suppress their invasive phenotype. Because tamoxifen interacts with targets implicated in Ca2+ homeostasis, we explored the possibility that the restoration of E-cadherin function in MCF7/6 cells induced by this drug could be affected by Ca2+ modulators. Two different Ca2+ channel antagonists (verapamil and nifedipine) potentiated the effect of tamoxifen on E-cadherin function, as evaluated with a fast cell aggregation assay. These molecules decreased the tamoxifen concentration needed to restore the E-cadherin function from 10(-6) M to 10(-7) M. When incubated with a Ca2+ channel agonist, Bay K8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methylphenyl)- pyridine-5-carboxylate), the effect of tamoxifen on E-cadherin function was completely abolished. These results demonstrate that the restoration of the E-cadherin function induced by tamoxifen depends, at least in part, on a Ca2+ pathway, and support the evidence of an effect of tamoxifen on Ca(2+)-dependent mechanisms. Our data also suggest that Ca2+ channel modulators could make it possible to decrease the dose of tamoxifen administered to patients without reducing the therapeutic effects. [less ▲]

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See detailPoly[alkyl methacrylate-b-butadiene-b-alkyl methacrylate] triblock copolymers : synthesis, morphology, and mechanical properties at high temperatures
Yu, Jian Ming; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8362-8370

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl ... [more ▼]

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl methacrylate) (PIBMA), have been successfully synthesized by sequential anionic polymerization of butadiene and methacrylates with the diadduct of tert-butyllithium to m-diisopropenylbenzene as a difunctional initiator. Block copolymers of a narrow molecular weight distribution (1.10) have been analyzed by differential scanning calorimetry, transmission electron microscopy, and dynamic mechanical analysis. These materials are phase-separated and have high mechanical performances. Special attention has been paid to the service temperature of these thermoplastic elastomers in comparison with a styrene−butadiene−styrene (SBS) triblock copolymer. The upper service temperature (UST) has been estimated from the temperature dependence of the tensile properties in the 25−150 °C range and found to change with the outer blocks. Polystyrene (Tg = 100°C) is at the origin of the lower UST, which is however comparable to PEMA (Tg = 90 °C) and P-t-BMA (Tg = 116 °C) containing triblock copolymers of similar molecular weight and composition. PMMA (Tg = 132 °C) outer blocks increase the UST of the triblocks, which is further increased by hydrogenation of the PBD midblock. The higher UST has been found for a PIBMA (Tg = 202 °C)-containing triblock copolymer that shows an ultimate tensile strength higher than 2 MPa at 150 °C. [less ▲]

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See detailTriblock copolymer based thermoreversible gels. 3. Effect of stereocomplexation with iPMMA
Yu, Jian Ming; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8371-9378

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large ... [more ▼]

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large range of syndio/iso mixing ratio (s/i). Differential scanning calorimetry (DSC) shows that two types of association contribute to the gel formation, i.e., the self-aggregation of the sPMMA outer blocks and the stereocomplexation of the sPMMA outer blocks with iPMMA. At low iPMMA contents (s/i = 30/1), self-association of the outer blocks accounts for the gelation process, although stereocomplexation occurs. Stereocomplexation becomes the dominant gelation mechanism at a high enough iPMMA content (s/i = 2/1). Thus, gelation is observed at a copolymer concentration as low as 1 wt %. The time dependence of the storage (G‘) and loss (G‘‘) moduli has been measured in the 0.08−1Hz frequency range in order to probe the gelation process. At the gel point, where the loss angle (tan δc = G‘‘/G‘) is independent of the probing frequency, the sample fits in the typical power law G‘(ω) G‘‘(ω) ωΔ. While the gelation time is greatly influenced by the s/i mixing ratio, the scaling exponent Δ is essentially constant in the range of 0.70−0.75. The Δ value agrees with theoretical predictions as well as with experimental values reported for some chemical gels but it is different from the experimental values reported for most physical gels. The Δ value is also independent of the PBD microstructure and it also holds for sPMMA-polystyrene (PS)−PBD−PS−sPMMA (MSBSM) pentablock copolymers. Therefore, the value of Δ appears to be a typical exponent for thermoplastic gels based on triblock copolymers of the ABA type in o-xylene. [less ▲]

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See detailInterleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates
Bonizzi, Giuseppina; Dejardin, Emmanuel ULg; Piret, Bernard et al

in European Journal of Biochemistry (1996), 242(3), 544-9

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B ... [more ▼]

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) in various cell types. Several studies have indicated that NF-kappa B activation depends strictly on the production of reactive oxygen intermediates. In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines (OVCAR-3, SKOV-3, MCF7 A/Z). In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105. We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Our study demonstrated that several signaling pathways lead to the activation of NF-kappa B, following IL-1 beta treatment in different cell types. [less ▲]

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See detailIdentification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein.
Clausse, Nathalie; Jackers, Pascale ULg; Jares, P. et al

in DNA & Cell Biology (1996), 15(12), 1009-23

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents ... [more ▼]

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents intriguing multifunctional properties because it has been characterized as the precursor of the metastasis-associated 67-kD laminin receptor (67LR) and as a cytoplasmic ribosomal-associated protein. The isolation of the 37LRP/p40 gene is a prerequisite for identifying the molecular mechanisms responsible for the constant up-regulation of the 67LR expression in cancer cells. To date, the active 37LRP/p40 gene has never been identified in any species due to the existence of multiple pseudogenes in most vertebrates genomes. In this study, we report for the first time the gene structure and potential regulatory sequences of the 37 LRP/p40 gene. The chicken genome was selected to undergo this characterization because it is the only known vertebrate that bears a single 37 LRP/p40 gene copy. The 37 LRP/p40 active gene is composed of 7 exons and 6 introns and bears features characteristic of a ribosomal protein gene. It does not bear a classical TATA box and it exhibits several transcription initiation sites as demonstrated by RNase protection assay and primer extension. Analysis of potential regulatory regions suggests that gene expression is driven not only by the 5' genomic region but also by the 5' untranslated and intron 1 sequences. On the basis of gene structure and extensive protein evolutionary study, we found that the carboxyterminal domain of the protein is a conserved lock-and-key structure/function domain that could be involved in the biosynthesis of the higher-molecular-weight 67-kD laminin receptor in vertebrates, whereas the central core of the protein would be responsible for the ribosome associated function. The first identification of the active 37LRP/p40 gene presented in this study is a critical step toward the isolation of the corresponding human gene and the understanding of the molecular mechanisms involved in the up-regulation of its expression during tumor invasion and metastasis. [less ▲]

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See detailReduction in Requirements for Allogeneic Blood Products: Pharmacologic Methods
Janssens, Marc ULg; Hartstein, Gary ULg; David, Jean-Louis ULg

in Annals of Thoracic Surgery (1996), 62(6), 1944-50

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic ... [more ▼]

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic antifibrinolytics. METHODS: A review of the literature was carried out to help the reader define the indications of these drugs during cardiopulmonary bypass operations, highlight the questions that remain concerning their indications and modes of action, and suggest future studies to answer these remaining questions. RESULTS: Prostacyclin reduces platelet trauma induced by extracorporeal circulation but does not effectively reduce postoperative bleeding and transfusion requirements. Desmopressin acts as a "glue," improving platelet adhesion, and may be effective when postoperative bleeding is excessive, but its routine use in cardiac operations cannot be recommended. Natural and synthetic antifibrinolytics inhibit plasmin and plasmin-induced platelet dysfunction. These agents have been shown to decrease bleeding and the need for allogeneic transfusions after open heart operations. However, with antifibrinolytic drugs, the risk of thromboembolic phenomena cannot be neglected. With aprotinin, this risk appears to be minimal when the drug is used at concentrations high enough to inhibit plasma kallikrein also. CONCLUSIONS: Prophylactic antifibrinolytics are efficacious, but their routine use remains controversial, both for economic reasons and for fear of thromboembolic complications. [less ▲]

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See detailAnionic polymerization of various methacrylates initiated with LiCl-complexed sBuLi
Antoun, S.; Wang, Jin-Shan; Jérôme, Robert ULg et al

in Polymer (1996), 37(25), 5755-5759

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert ... [more ▼]

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert-butyl methacrylate (tBuMA), glycidyl methacrylate (GMA), and dimethyl amino ethyl methacrylate (DMAEMA) in tetrahydrofuran at -78°C. Only the homopolymerization of tBuMA proceeds in a living manner, as evidenced by both the linear plot of experimental molecular weight (Mnexp) vs theoretical ones (Mncal,) (slope % 0.93) and monomer resumption experiments. However, three types of block copolymers, i.e. PtBuMA-b-PMMA, PtBuMA-b-PGMA, PtBuMA-b-PDMAEMA, have been successfully synthesized with a predictable molecular weight, and narrow molecular weight distribution. [less ▲]

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See detailStaging of the Mediastinum: Value of Positron Emission Tomography Imaging in Non-Small Cell Lung Cancer
Bury, Thierry ULg; Paulus, P.; Dowlati, A. et al

in European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology (1996), 9(12), 2560-4

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical ... [more ▼]

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical imaging features, positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) depends mainly on the metabolic characteristics of a tissue for the diagnosis of disease. We have performed a prospective study comparing FDG-PET and CT of the thorax in the presurgical assessment of the mediastinum in 50 patients with newly diagnosed non-small cell lung cancer (NSCLC). CT and PET scans were interpreted separately, and results were compared to pathological staging obtained during thoracotomy. Hilar or mediastinal lymph node involvement was present in 58%. In staging for lymph node involvement, CT had a sensitivity of 72% and specificity of 81%, whereas PET had a sensitivity and specificity of 90% and 86%, respectively. When the PET study was compared to histological results, there were four cases showing more advanced mediastinal involvement with PET and four cases showing less involvement with PET. From our preliminary results, we conclude that positron emission tomography with 18-fluorodeoxyglucose is significantly more accurate than computed tomography in the mediastinal staging of non-small cell lung cancer. [less ▲]

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See detailScreening and characterization of specific anti-lipopolysaccharide antibodies in Belgian blood donors by enzyme-linked immunosorbent assays
Nys, Monique ULg; Laub, R.; Damas, Pierre ULg et al

in European Journal of Clinical Investigation (1996), 26(12), 1134-1142

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs ... [more ▼]

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs) were developed to perform longitudinal studies of the serological response to a large panel of smooth and rough purified lipopolysaccharide (LPS) extracts in a population of healthy blood donors. To accomplish this, 1612 human serum samples from volunteer blood donors collected by seven different blood banks in Belgium were screened and specific IgM and IgG activities were measured. Approximately 17% of the donors had anti-LPS concentrations higher than 40 mg L-1. Of these, 10.9% had anti-smooth LPS antibodies, 3.7% had anti-rough LPS antibodies and 2.8% were found to be positive towards both types of LPS. The mean anti-LPS antibody concentration was 8 mg L-1 for rough LPS and 14 mg L-1 for smooth LPS. Age- and sex-related distributions of the activities indicated that the greatest prevalence of high anti-LPS concentration was in women aged 40-49 years and in men older than 60 years. Differential absorption experiments showed that the pooled serum of selected blood donors contained a mixture of specific and cross-reacting antibodies. We detected predominantly anti-LPS activities due to the IgG1 and IgG2 subclasses. The range of specificities to different LPS was increased by the pooling of selected sera. It was concluded that pools of naturally occurring specific anti-LPS immunoglobulin antibodies may be obtained in Belgium by screening blood donors using ELISAs that we have developed. [less ▲]

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See detailTnp-470 (Agm-1470): Mechanisms of Action and Early Clinical Development
Castronovo, Vincenzo ULg; Belotti, D.

in European Journal of Cancer (1996), 32A(14), 2520-7

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See detailGliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ULg; de Leval, L.; Reznik, M.

in Acta Neurologica Belgica (1996), 96(4), 294-300

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]

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See detailDo Sex Differences in the Brain Explain Sex Differences in the Hormonal Induction of Reproductive Behavior? What 25 Years of Research on the Japanese Quail Tells Us
Balthazart, Jacques ULg; Tlemcani, O.; Ball, G. F.

in Hormones & Behavior (1996), 30(4), 627-61

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the ... [more ▼]

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the sex specificity of androgens and estrogens. [less ▲]

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See detailTreatment of Excessive Mediastinal Bleeding after Cardiopulmonary Bypass
Hartstein, Gary ULg; Janssens, Marc ULg

in Annals of Thoracic Surgery (1996), 62(6), 1951-4

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective ... [more ▼]

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective diagnostic work-up, based on the knowledge of the pathophysiology induced by cardiopulmonary bypass. METHODS: Possible causes, diagnostic methods available, and therapeutic approaches are reviewed in the light of the literature published on excessive bleeding after cardiac operations. RESULTS: When bleeding is massive (> 250 to 300 mL/h for the first 2 hours, > 150 mL/h thereafter), immediate surgical reexploration is mandatory. When bleeding is less important (50 to 150 mL/h), the decision to reoperate should be based on the presence of hemodynamic compromise or a suspected surgical cause. Otherwise, coagulation testing should allow the correction of hemostatic defects as appropriate with protamine, platelet concentrates, fresh frozen plasma, desmopressin, or antifibrinolytics. Hypothermia and hypotension should be corrected and a trial of positive end-expiratory pressure may be considered if diffuse mediastinal oozing (especially from the bed of the mammary artery) is suspected. CONCLUSIONS: A protocol is suggested to guide treatment, taking into account the rapidity of blood loss and the suspected underlying cause. [less ▲]

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See detailLa CEI entre mythes et réalités
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailMicrostructure development in isothermally melt-textured 123-211 composite materials
Auguste, F.; Rulmont, André ULg; Vandewalle, Nicolas ULg et al

in Journal of Low Temperature Physics (1996), 105(5-6), 1439-1444

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the ... [more ▼]

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the superconducting 123 grain boundary and the solid-liquid interface features are emphasized. The quality of the materials has been investigated by thermopower and thermal conductivity measurements. A seeded-melt texturing technique has been also tested in order to grow large single-domain of DyBa2Cu3O7-y. The chosen seed was a Dy2O3 single crystal. [less ▲]

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See detailAdaptation de la méthodologie des langues étrangères aux styles d'apprentissage des élèves : un nouveau miroir aux alouettes ?
Simons, Germain ULg

in Etudes et Travaux (1996), (1), 19-38

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le ... [more ▼]

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le processus d'apprentissage de la langue étrangère et sur le niveau de performance atteint par les différents types d'apprenants. Cette conception des styles d'apprentissage conduit naturellement à supposer que l'enseignement optimal d'une langue étrangère est celui dont la méthodologie est en adéquation avec le style d'apprentissage des élèves. Selon G. Simons, il convient d'aborder ce type de recherche avec la plus grande prudence si on ne veut pas qu'elle devienne un miroir aux alouettes, un de plus. Pour éviter ce piège, G. Simons analyse quelques problèmes sous-jacents à ce domaine de recherche et tente d'y apporter des solutions. [less ▲]

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See detailOncological Applications of Positron Emission Tomography with Fluorine-18 Fluorodeoxyglucose
Rigo, Pierre ULg; Paulus, Patrick; Kaschten, Bruno et al

in European Journal of Nuclear Medicine (1996), 23(12), 1641-74

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical ... [more ▼]

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and follow-up. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved. [less ▲]

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See detailBeta-Carbolines Induce Apoptotic Death of Cerebellar Granule Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Marie ULg; Coucke, Paul et al

in Neuroreport (1996), 7(18), 3041-5

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n ... [more ▼]

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n-methyl-beta-carboline-3-carboxamide, which are negative allosteric modulators of the GABAA receptor acting at the benzodiazepine site, are neurotoxic for cerebellar granule neurones in culture. The beta-carboline-induced neuronal death is apoptotic since DNA internucleosomal fragmentation was induced and the neurotoxicity could be prevented by inhibitors of mRNA or protein synthesis. As GABA and benzodiazepine ligands (diazepam and Ro 15-1788) protect cerebellar granule cells against beta-carboline-induced toxicity, these data raise the possibility that the interaction between the beta-carbolines and the GABAA receptor is the triggering event leading to neuronal apoptosis. [less ▲]

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