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See detailMisdiagnosed Malignancy in Transplanted Organs
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, M. et al

in Transplant International (1993), 6(1), 50-4

The case reports of three patients who received cancer-bearing organs at this institution are presented. A fourth recipient, who was to be transplanted with a cancerous kidney, was spared this disastrous ... [more ▼]

The case reports of three patients who received cancer-bearing organs at this institution are presented. A fourth recipient, who was to be transplanted with a cancerous kidney, was spared this disastrous complication. The relevant data regarding the donors is also alluded to, with special reference to the type and site of the primary malignancy. Following these case reports, the implications of these issues, their possible prevention, and further management are discussed. [less ▲]

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See detailPulmonary Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1993), 54(1), 168-73

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary ... [more ▼]

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary arterial hypertension in cattle. We determined whether the IV response to 5-HT in calves was attributable to stimulation of 5-HT2 receptors. Six healthy unsedated young bull calves of the Friesian (n = 4) and of the Belgian White and Blue (n = 2) breeds were used. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg of body weight) was administered IM 30 minutes before the cattle were given a 5-minute IV 5-HT infusion. Pulmonary function values were registered before, during, and after the 5-HT challenge infusion. Minute volume increased significantly, because of an increase in respiratory rate. Conversely, lung dynamic compliance, total pulmonary resistance, and pulmonary arterial pressure were not changed. We concluded that in cattle, 5-HT-induced ventilatory response is not mediated through activation of 5-HT2 receptors. However, the 5-HT2 receptors are involved in 5-HT-induced broncho- and pulmonary vasoconstriction. [less ▲]

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See detailA novel mutation in the proteolipid protein gene leading to Pelizaeus-Merzbacher disease.
Otterbach, B.; Stoffel, W.; RAMAEKERS, Vincent ULg

in Biological chemistry Hoppe-Seyler (1993), 374(1), 75-83

Point mutations of the gene of human proteolipid protein (PLP) have been recognized as the molecular basis of one form of leukodystrophy, the X-chromosome-linked Pelizaeus-Merzbacher disease (PMD). We ... [more ▼]

Point mutations of the gene of human proteolipid protein (PLP) have been recognized as the molecular basis of one form of leukodystrophy, the X-chromosome-linked Pelizaeus-Merzbacher disease (PMD). We report the molecular analysis of four PMD patients in three unrelated families and describe a point mutation (G-->A transition) in exon V which leads to the substitution of Gly216 by a serine residue in a highly conserved extracytosolic domain and a Mae I RFLP. Molecular modelling with energy minimization indicates that this seemingly minor alteration of the amino-acid sequence induces a considerable conformational change and tight packing of the polypeptide chain apparently not compatible with the regular PLP function in oligodendrocytes. This mutation has been detected and characterized by PCR amplification of genomic DNA using intron and exon primers and the complete sequence analysis of the seven exons and a 300 bp promoter region of the PLP gene of two affected brothers. The sequence analysis of a PCR fragment representing exon V amplified from genomic DNA of different kindreds of the pedigree revealed the mother as the only carrier indicating that the mutation has occurred de novo in the mother's germline. PLP gene (including the 8.8 kb intron I) rearrangements have been excluded by Southern blot hybridization and overlapping PCR amplification of genomic DNA. [less ▲]

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See detailPlasma Na-K ATPase inhibitor activity and intracellular ions during hemodialysis
Krzesinski, Jean-Marie ULg; Du, F.; Pequeux, M. L. et al

in International Journal of Artificial Organs (1993), 16(1), 23-30

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic ... [more ▼]

We have investigated the relationship between plasma Na-K ATPase inhibitor activity (EDLS) and intracellular ions in 37 uremic hemodialysed hypertensive patients, and in 20 normotensive non uremic controls (NC). As compared with the NC population, significantly enhanced values for erythrocyte (RBC) Na, Ca, platelet cytosolic Ca and EDLS were observed in all the uremic patients tested just before a dialysis session, as well as a decrease in RBC Ca ATPase and in the platelet pH. In uremia, significant correlations have been noted between RBC Na and platelet Ca (r = 0.6) or systolic BP (r = 0.45); between platelet Ca and systolic blood pressure (r = 0.8) or diastolic BP (r = 0.5) and between EDLS and RBC Na, Ca or platelet Ca (r = 0.5). Anti-hypertensive treatment has no influence on these parameters. During dialysis, a significant decrease has been noted in RBC Na, Ca, platelet Ca, SBP (only in untreated patients) and EDLS and an increase in RBC Ca ATPase and platelet pH. These modifications are significantly correlated with the weight change. [less ▲]

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See detailPhotophysical investigation of Rose Bengal in aqueous sodium taurocholate solutions
Seret, Alain ULg; Van de Vorst, Albert

in Journal of Photochemistry and Photobiology B : Biology (1993), 17(1), 47-56

The photophysics of rose bengal has been studied in aqueous sodium taurocholate solutions with or without 0.6 mol NaCl dm−3. The ground and first excited singlet states solubilize only in the aggregates ... [more ▼]

The photophysics of rose bengal has been studied in aqueous sodium taurocholate solutions with or without 0.6 mol NaCl dm−3. The ground and first excited singlet states solubilize only in the aggregates formed by sodium taurocholate, whereas the first triplet state solubilizes both in the bulk phase and in the aggregates. A lower limit of the corresponding entry and exit rate constants ke and ks, respectively has been estimated: ke ≥ 5 X 106 dm3 mol−1 s−1 (2x107 dm3 mol−1 s−1 with 0.6 mol NaCl dm−3) and ks ≥ 105 s−1. The triplet state as well as the semioxidized radical react with the taurocholate anion. The former reaction leads to the formation of semireduced dye. The latter is responsible for the detection of only semioxidized radicals which move freely in the aqueous phase. The results are compared with those obtained previously in aqueous sodium dodecyl sulphate solutions and the possible biological implication is discussed. [less ▲]

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See detailResults of metagnostic (system-oriented) and diagnostic (process-oriented) models
Beckers, Jean-Marie ULg; Haus, J.; Nihoul, Jacques ULg et al

in Progress in Belgian Oceanographic Research (1993)

After a review of the Mediterranean system, and the justification of the scientific interest, we examine the type of model (scope, purview and resolution) used for the description and simulation of the ... [more ▼]

After a review of the Mediterranean system, and the justification of the scientific interest, we examine the type of model (scope, purview and resolution) used for the description and simulation of the Mediterranean circulation from a system-oriented view and a process-oriented view. These two aspects of mathematical simulations are then illustrated by two examples: a) The simulation of the month to month variability of the general circulation in the Western Mediterranean Sea shows the main physical features, but the choice of initial conditions is crucial for a realistic simulation, and an inverse model is proven to be absolutely necessary for a valuable prognostic model. b) Secondly, a high resolution simulation of the Algerian Current instability is performed. It is well known that the Atlantic water flows along the Algerian coast as a light water intrusion. This current is unstable, and mesoscale activities generate cyclones and anticyclones, but only the latter grow enough to get separated from the mean flow. Numerical simulations, in an idealized case, and reality show strong instabilities that are analyzed by energy budgets. It is suggested that the instabilities are primarily baroclinic, which is consistent with initial vertical movements at the front. [less ▲]

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See detailLa myocardiopathie hypertrophique obstructive: options therapeutiques chirurgicales.
Radermecker, Marc ULg; SAKALIHASAN, Natzi ULg; Partoune, B. et al

in Revue Médicale de Liège (1993), 48(12), 659-65

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See detailEffects of Age and Indomethacin on Response and Sensitivity of Pulmonary Artery to Phenylephrine and to Histamine in Pigs
Gustin, Pascal ULg; Ansay, Michel; Advenier, C.

in Journal of Veterinary Pharmacology & Therapeutics (1993), 16(2), 207-213

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and ... [more ▼]

The vasoconstrictor effects of phenylephrine and histamine were investigated in isolated strips of pulmonary arteries in pigs during ageing. Interactions between phenylephrine-induced responses and arachidonic acid derivatives were also studied by incubating the blood-vessels with indomethacin. Potency (pD2 values) and maximal effects (Emaxx) recorded in 5-week-old piglets (group I, n= 5) with phenylephrine [5.71 ± 0.17 and 0.76 ± 0.22 g/mg of dry tissue respectively (mean ± SEM)] were similar to values found in 12-week-old animals (group 2, n = 5) (5.49 ± 0.30 and 1.06 ± 0.27 g/mg of dry tissue respectively). The sensitivity and responsiveness of tissues to this agonist were significantly reduced in 26-week-old mature pigs (group 3, n = 6) as indicated by the decrease in pD2 (3.91 ± 0.23; P < 0.01) and Emax (0.27 ± 0.13 g/mg of dry tissue; P < 0.05) values observed in this group. Histamine (10_3M)-induced maximal responses (Emax) were significantly higher in group 2 (2.23 ± 0.49 g/mg) than in group 1 (0.85 ± 0.11 g/mg; P < 0.05) and in group 3 (0.48 ± 0.10 g/mg; P < 0.01). In 5-week-old animals, indomethacin (3.10˜5M) significantly (P < 0.05) shifted the concentration-response curve to phenylephrine to the right (0.28 log. units) and depressed contractions to this drug as shown by the significant decrease of 39.5% (P < 0.05) in Emax. This cyclo-oxygenase inhibitor had no effect in other groups. These data indicate that phenylephrine is a potent and effective vasoconstrictor agent for the main pulmonary arteries in 5-week-old piglets and that alpha-1-adrenergic-induced contractions are enhanced by cyclo-oxygenase products. These findings can be related with the high reactivity of pulmonary vascular smooth muscles in these animals [less ▲]

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See detailBiological control of Botrytis cinerea and Penicillium sp. on post-harvest apples two antagonist yeasts.
Jijakli, Haissam ULg; Lepoivre, Philippe ULg; Tossut, P. et al

in Mededelingen - Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent (1993), 58(3b),

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See detailImmunodetection of RNA on ultra-thin sections incubated with polyadenylate nucleotidyl transferase.
Thiry, Marc ULg

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1993), 41(5), 657-65

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and ... [more ▼]

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and biotinylated ATP. The labeled nucleotides bound to RNA at the surface of the ultra-thin sections were than visualized by an indirect immunogold labeling technique. The resulting labeling pattern was dependent on the presence of divalent cations in the PnT medium. The method revealed with great precision the specific RNA-containing structures within Ehrlich tumor cells. The method is applicable to Epon sections. However, the labeling intensity varies according to the fixation used. Best results were obtained on acetylated cell sections. The method can be combined with EDTA regressive staining. The in situ PnT method provides a very useful tool for pinpointing the precise location of RNA within biological material at the ultrastructural level. [less ▲]

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See detailProperties and primary structure of a cold-adapted lipase from an Antarctic bacterium
Arpigny, J. L.; Feller, Georges ULg; Gerday, Charles ULg

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailModeling of the chemical processes in a longwall face underground gasifier at great depth
COEME, Antoinette; Pirard, Jean-Paul ULg; MOSTADE, Marc

in In Situ (1993), 17(1), 83-104

In order to simulate the cavity growth of an underground gasifier in thin seams, at great depth, Wilks1,2 has developed an original model based on the distribution of fluid flows around an injection well ... [more ▼]

In order to simulate the cavity growth of an underground gasifier in thin seams, at great depth, Wilks1,2 has developed an original model based on the distribution of fluid flows around an injection well. In this paper, we aim to introduce within this model a description of chemical processes on the wall and within the fluid phase, in order to determine the temperature and concentration profiles along the coal wall. These profiles are dependent only on two factors: the transfer coefficients and the energy balance of the gas generator. A study of the sensitivity of the operating variables has been carried out. [less ▲]

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See detailWavenumbers and Oscillator Strengths for n1,3L - n'1,3L' (2 <n<50) Rydberg transitions of neutral Helium
Biémont, Emile ULg; Quinet, Pascal ULg

in Bulletin de la Société Royale des Sciences de Liège (1993), 62(5-6), 373-398

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See detailTHERMAL-CONDUCTIVITY OF TWINNED YBA2CU3O7-X AND TWEEDED YBA2(CU0.95FE0.05)3O7-X IN A MAGNETIC-FIELD - EVIDENCE FOR INTRINSIC PROXIMITY EFFECT
Bougrine, Hassan ULg; SERGEENKOV, S.; Ausloos, Marcel ULg et al

in Solid State Communications (1993), 86(8), 513-516

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to ... [more ▼]

The behavior of the thermal conductivity kappa of twinned YBa2Cu3O7-x and tweeded YBa2(Cu0.95Fe0.05)3O7-x polycrystals in a magnetic field up to 5 T is presented. Data as a function of field are shown to depart from the usual linear behavior of thermal magnetoresistivity (TMR) kappa-1 (B) for conventional superconductors. A set of stretched exponential laws, of the form kappa-1 (B) - kappa-1 (0) = CB exp(-pB(q)) has been found to describe our data with q decreasing with temperature from 1 to 1/2 and from 1/2 to 1/4 for pure and iron-doped samples, respectively, in contrast to the unique interpolation formula (q = 1/4) for TMR proposed recently by Richardson et al. [1] to fit their data on twinned and untwinned single crystals. Such a complex behavior of TMR in the high field region is supposed to originate from extended defect mediated intrinsic proximity effect in both samples. The proposed interpretation is based on incorporating two types of phonon scatterers, free (unpinned) and pinned (by the defect cores) vortices, into a conventional picture of phonon-vortex scattering mechanism. [less ▲]

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See detailDire et écrire pour aller lire en géographie
Partoune, Christine ULg

in Bulletin de la Société Géographique de Liège (1993), 28

Texts, maps and the various documents that we use at school are almost all basically rational and cut off from reality. Before tackling them, it is proposed that we first delve into this "reality" by ... [more ▼]

Texts, maps and the various documents that we use at school are almost all basically rational and cut off from reality. Before tackling them, it is proposed that we first delve into this "reality" by means of fiction. Verbal expression gaines and written games enable us to explore beforehand the mental representation of pupils and provide us with interesting questions for subsequent research. Two approaches of this type are detailed here in order to propose a discussion of their interest and of their relevance. [less ▲]

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See detailFlexible Technique for Multiple Organ Procurement in Rats: A Training and Research Tool in Transplantation
D'Silva, M.; Pirenne, J.; Bonnet, Pierre ULg et al

in Microsurgery (1993), 14(5), 342-9

Multiple organ procurement techniques are increasingly popular in many transplant centers. This paper describes a technique for multiorgan unit(s) explantation in rats. The procedure involves in situ ... [more ▼]

Multiple organ procurement techniques are increasingly popular in many transplant centers. This paper describes a technique for multiorgan unit(s) explantation in rats. The procedure involves in situ preliminary dissection, cold perfusion of the thoracic and abdominal organ units as separate procedures, explantation, and finally the ex situ isolation of various organ units as single and/or multiple organ combination units. The procedure is feasible, allows for flexibility in the separation of combination organ units, and is reproducible. The exercise is provided as a training and research tool for clinical and research transplant surgeons. The technique is also presented as an animal model for clinical organ sharing. [less ▲]

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See detailTabagisme et poids corporel.
PAQUOT, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1993), 51

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See detailA new topical treatment for resistant herpes simplex infections.
Snoeck, R.; Andrei, G.; De Clercq, E. et al

in New England Journal of Medicine [=NEJM] (1993), 329(13), 968-9

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See detailEmperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Tsunoda, R.; Nakayama, M.; Heinen, Ernst ULg et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailAnalytical calculation of the electrostatic interaction energy within the CNDO framework
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in International Journal of Quantum Chemistry (1993), 46(6), 711-734

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab ... [more ▼]

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab initio results for small systems such as water-formamide, methanol-water-imidazole, or guanine-cytosine and with AM1 results for two large systems: a molecular tweezer + the 9-methyladenine complex and a model active site of the alpha-chymotrypsin and its ligand complex. This approach is efficient in providing reliable conformers for large molecular systems in a very fast way. [less ▲]

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See detailDe Dakconstructie van de Karmelietenkerk, eerste dendrochronologische analyse
Hoffsummer, Patrick ULg; Houbrechts, David

in Stadsarcheologie (1993), 17(2), 29-34

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See detailLésion du nerf spinal accessoire
WANG, François-Charles ULg; Laurent, Luc; CRIELAARD, Jean-Michel ULg

in Acta physiotherapeutica (1993)

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See detailComparing measures of poverty and relative deprivation: an example for Belgium
Delhausse, Bernard; Luttgens, Axel; Perelman, Sergio ULg

in Journal of Population Economics (1993), 6

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of ... [more ▼]

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of deprivation, based on the observation of consumption events, is constructed through a particular econometric procedure proposed by Desai and Shah (1988). These alternative measures are then compared on a sample composed of 6380 Belgian households. Such an analysis can be expected to provide some further insight into the problem of measuring poverty, which has been the subject of a recent controversial debate. [less ▲]

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See detailEvaluation of efficacy and safety of oral tiludronate in Paget's disease of bone: a double-blind, dose-ranging, placebo-controlled study
Reginster, Jean-Yves ULg; Colson, F; Morlock, G et al

in Arthritis and Rheumatism (1993), 36

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See detailTypes de circulation atmosphériques, advection des masses d'air et variations climatiques: Le cas des hivers doux et des hivers rudes récents en Belgique
Erpicum, Michel ULg; Mabille, Georges ULg; Alexandre, Jean ULg

in Publications de l'Association Internationale de Climatologie (1993), 6

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative ... [more ▼]

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative conditions observed at tropospheric lower level and horizontal motion of very thin air masses (below 850 hPa level) seem to be more important for the explanation of ground level temperature. [less ▲]

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See detailAdemhalingsfunktie als eventueel limiterende factor voor de gezondheid, de produktie en prestaties bij de dieren
Lekeux, Pierre ULg

in Vlaams Diergeneeskundig Tijdschrift (1993), 62

After a description of the varions links of the oxygen line and a definition of the notion «limiting factor», this paper describes why the pulmonary function can become a limiting factor in some domestic ... [more ▼]

After a description of the varions links of the oxygen line and a definition of the notion «limiting factor», this paper describes why the pulmonary function can become a limiting factor in some domestic animals which have been intensively selected for improved economic or athletic performances [less ▲]

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See detailMallarmé, “termite silencieux”. L’auto-liquidation de la poésie
Durand, Pascal ULg

in Romantisme (1993), 81

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See detailCharacterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.
Peers, Bernard ULg; Johnson, T.; Ferreri, K. et al

in Molecular Endocrinology (1993), 7(10), 1275-83

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number ... [more ▼]

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number of homeobox-type factors have been proposed as key regulators of individual peptide genes in the pancreas, their cellular distribution and relative abundance remain uncharacterized. Also, their overlapping DNA binding specificities have further obscured the regulatory functions these factors perform during development. In this report we characterize a novel homeobox-type somatostatin transactivating factor termed STF-1, which is uniformly expressed in cells of the endocrine pancreas and small intestine. The 283-amino acid STF-1 protein binds to tissue-specific elements within the somatostatin promoter and stimulates somatostatin gene expression both in vivo and in vitro. Remarkably, STF-1 comprises the predominant tissue-specific element-binding activity in nuclear extracts from somatostatin-producing pancreatic islet cells, suggesting that this protein may have a primary role in regulating peptide hormone expression and specifying endocrine cell lineage in the developing gut. [less ▲]

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See detailNew gamma-lactam homologs of penems
Marchand-Brynaert, Jacqueline; Couplet, Blandine; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry Letters (1993), 3(11), 2303-2308

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See detailP. Colon. Inv. 4781 verso: vente d'une esclave
Straus, Jean ULg

in Zeitschrift für Papyrologie und Epigraphik (1993), 98

Edition du contrat de vente d'une esclave. Papyrus grec d'Egypte. Ptolémaïs Euergétis, 3 décmebre 65

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See detailOstéoporose postménopausique: le point sur la thérapeutique
Reginster, Jean-Yves ULg

in Medisearch (1993), 73

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See detailMutations in type 1 procollagen that cause osteogenesis imperfecta: effects of the mutations on the assembly of collagen into fibrils, the basis of phenotypic variations, and potential antisense therapies.
Prockop, D. J.; Colige, Alain ULg; Helminen, H. et al

in Journal of Bone and Mineral Research (1993), 8 Suppl 2

Work by a large number of investigators over the last decade has established that over 90% of patients with osteogenesis imperfecta have mutations in one of the two genes for type I procollagen, that most ... [more ▼]

Work by a large number of investigators over the last decade has established that over 90% of patients with osteogenesis imperfecta have mutations in one of the two genes for type I procollagen, that most unrelated probands have different mutations in the genes, and that the mutations found in most of the serious variants of the disease cause synthesis of abnormal pro alpha chains of the protein. The results have demonstrated that synthesis of structurally abnormal but partially functional pro alpha chains can interfere with folding of the central region of the protein into a triple-helical conformation, prevent processing of the N-terminal propeptides of procollagen, or produce subtle alterations in conformation that interfere with the self-assembly of the protein into collagen fibrils. One of the unsolved mysteries about the disease is why some mutations produce severe phenotypes, whereas very similar mutations produce mild phenotypes. Recent studies in transgenic mice suggest that nongenetic factors, such as stochastic events during development, may determine the severity of the disease phenotype produced by a specific mutation. Also, recent results raised the possibility that strategies of antisense gene therapy may be effective in treating the disease some time in the future. Specific inhibition of expression of a mutated collagen gene has been obtained with antisense oligonucleotides in cell culture experiments. However, there is no means of selective delivery of antisense oligonucleotides to the appropriate tissues. [less ▲]

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See detailThe use of the soil map of Belgium in the assessment of landslide risk
Closson, Damien; Engels, Patrick ULg; Demaret, Xavier

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(3), 165172

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See detailNew f values in C I and the CNO Abundances in the Sun
Biémont, Emile ULg; Hibbert, A.; Godefroid, M. et al

in Astrophysical Journal (1993), 412

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See detailAnalgésie postopératoire par analgésie péridurale autocontrôlée
Joris, Jean ULg

in Douleur et analgésie (1993), 4

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See detailCloning and overexpression of the triosephosphate isomerase genes from psychrophilic and thermophilic bacteria. Structural comparison of the predicted protein sequences
Rentier-Delrue, Françoise ULg; Mande, Shekhar C; Moyens, Sylvianne et al

in Journal of Molecular Biology (1993), 229(1), 85-93

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments ... [more ▼]

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments. The TIM gene from psychrophilic bacteria Moraxella sp. TA137 was cloned and its nucleotide sequence determined. Its deduced amino acid sequence revealed 34% identity with the thermophilic bacteria Bacillus stearothermophilus TIM. Expression vectors were constructed and recombinant Moraxella TA137 and Bacillus stearothermophilus TIMs were overproduced and purified to homogeneity. Recombinant TIM inactivation constants (Ki), measured at various temperatures, compared to those of the mesophilic Escherichia coli recombinant TIM clearly show that Moraxella TA137 and B. stearothermophilus TIMs have respectively psychrophilic and thermophilic characteristics. To try to elucidate the structure-thermolability and structure-thermostability relationship, factors affecting the overall stability of these two TIMs were examined, based on the alignment with the mesophilic chicken TIM, the three-dimensional structure of which is already known. From this comparison, it appears that the adaptability of TIM to high temperature is favored by better stabilizing residues for the helix dipole as well as better helix-forming residues whereas the adaptability of TIM to low temperature seems to reside in the nature of helix-capping residues. [less ▲]

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See detailSequence of the triosephosphate isomerase-encoding gene isolated from the thermophile Bacillus stearothermophilus
Rentier-Delrue, Françoise ULg; Moyens, Sylvianne; Lion, Michelle ULg et al

in Gene (1993), 134(1), 137-8

By analysis of genomic clones, we have determined the complete nucleotide sequence of the gene encoding triosephosphate isomerase (TIM; EC 5.3.1.1) in the thermophilic bacterium, Bacillus ... [more ▼]

By analysis of genomic clones, we have determined the complete nucleotide sequence of the gene encoding triosephosphate isomerase (TIM; EC 5.3.1.1) in the thermophilic bacterium, Bacillus stearothermophilus. The gene encodes a 253-amino-acid TIM which is 39% identical to that of the mesophile, Escherichia coli. [less ▲]

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See detailEnzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes.
Lins, Laurence ULg; Piron, S.; Conrath, K. et al

in Biochimica et Biophysica Acta (1993), 1151(2), 137-42

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form ... [more ▼]

Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable apolipoproteins to bind to lipid bilayer and to form discoidal particles of defined dimensions. While the knowledge of the apo A-I sequence and secondary structure has been used to make predictions about its mode of association with lipids, the available experimental data necessary to propose a precise model of these discoidal structures are still limited. An important step in our understanding of these structures would be to identify the apolipoprotein lipid-associated domains. Proteolysis of apo A-I-DMPC reconstituted HDL (rHDL) and free apo A-I is used here to identify lipid-protected domains of apo A-I. Free cleaved peptides were separated from rHDL associated peptides by density gradient centrifugation. The lipid-associated peptides were further analyzed by SDS-PAGE and transferred by Western blot to a ProBlott membrane for sequencing. Cleavage occurred at residue 43 with proteinase K, 46 with trypsin and residue 47 or 48 with pronase. A large domain from about residue 45 to the C-terminal remains highly protected against hydrolysis eventhough it contains several bonds susceptible to proteolytic cleavage. No protected fragments were detected by SDS-PAGE after enzymatic cleavage of free apo A-I in identical experimental conditions. [less ▲]

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See detailSubjective shortening in human's memory for stimulus duration
Wearden, J. H.; Ferrara, André ULg

in Quarterly Journal of Experimental Psychology (1993), 46B(2), 163-186

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See detailL'état de stress post-traumatique chez les brûlés : Une revue.
Machurot, Pierre-Yves; Hansenne, Michel ULg; Pitchot, William ULg et al

in Acta Psychiatrica Belgica (1993), 93 Spec No

While post-traumatic stress disorder has drawn increasing interest over the last years, very few studies have been focused to burned patients. In its first part, this article provides a brief reminder of ... [more ▼]

While post-traumatic stress disorder has drawn increasing interest over the last years, very few studies have been focused to burned patients. In its first part, this article provides a brief reminder of the symptomatology of post-traumatic stress disorder, of its various pathogenic theories as well as its various treatment approaches. The second part of the article reviews more specifically the literature about post-traumatic stress disorder in burned patients, emphasizing the need of a rapid and effective psychological therapy. [less ▲]

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See detailComparison between culture of bovine embryos in vitro versus development in rabbit oviducts and in vivo
Ectors, Fabien ULg; Thonon, Fabienne; Delval, Alain et al

in Livestock Production Science (1993), 36

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC ... [more ▼]

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC conditioned medium (CM) or in rabbit oviducts, versus in vivo produced embryos. There was no significant difference in terms of percentages of cleaved and 8-cell stages obtained between CM and BOEC. In CM, 24.8% of the cleaved embryos became blastocysts. In BOEC, 14.5% of the cleaved embryos became blastocysts. Among the 190 zygotes transferred in the rabbit oviducts, 127 have been recovered 5 days later, and 17.4% became blastocysts. There was no significant difference in term of blastocyst formation between the development in rabbit and in BOEC. However, there was a significant difference between the CM group and the two other groups. The numbers of cells in blastocysts from different sources were investigated: in vivo blastocysts contained 107 cells assumed to be 100%, in vitro blastocysts developed in rabbit oviduct 100.1 cells (93.3%), BOEC blastocysts 90.8 cells (84.6%) and CM blastocysts 72.3 cells (67.3%). This study confirmed earlier works on the oviduct effect on blastocyst quality in terms of development rate and cell number. [less ▲]

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailHypofractionation in retinoblastoma: an increased risk of retinopathy.
Coucke, Philippe ULg; Mirimanoff, R-O; Schmid, C et al

in Radiotherapy & Oncology (1993), 28

Forty-four eyes in 38 children were treated between 1963 and 1991 by external radiotherapy for retinoblastoma. Treatment modalities varied widely during this period; in addition to radiotherapy there was ... [more ▼]

Forty-four eyes in 38 children were treated between 1963 and 1991 by external radiotherapy for retinoblastoma. Treatment modalities varied widely during this period; in addition to radiotherapy there was chemotherapy (16/44), photocoagulation (14/44), and laser therapy or cryotherapy (14/44). Treatment technique and dose fractionation also varied widely; lateral beam technique (39/44) versus anterior or anterior/lateral beam; doses per fraction ranged from 1 to 4.5 Gy, total doses from 30 to 61.5 Gy, and overall times from 22 to 49 days. Patients were followed at 3-month intervals, and actuarial survival at 10 years was 88%, with 62% local control. Ten eyes showed clinical evidence of retinopathy. A multivariate analysis of factors associated with increased risk of retinopathy was carried out using the Cox proportional hazards model and the mixture model of Farewell. The estimated latent time was 17 months (95% confidence interval, 14-20 months). The only factors found to be significantly associated with retinopathy were total dose multiplied by dose per fraction, or total dose normalized to the equivalent total dose in 2-Gy fractions as estimated from the LQ model, and these gave equivalent descriptions. There were trends (not significant) for increased risk of retinopathy when treatments included chemotherapy or photocoagulation, and for decreased risk (also not significant) when cryotherapy was used in conjunction with radiotherapy. No significance could be attached to any of the following: number of sites per eye, Reese-Ellsworth stage, and family history. We conclude that hypofractionation carries a significant risk for retinopathy in the treatment of retinoblastoma. [less ▲]

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See detailClonage par transfert de noyau dans l'espèce bovine: premiers résultats
Ectors, Fabien ULg; Delval, Alain; Touati, Kamal ULg et al

in Annales de Médecine Vétérinaire (1993), 137(6), 427-431

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See detailSolid-state nuclear magnetic resonance studies of the transformation of the zeolite Y catalyst in the course of hydrochlorination of 1-methylcyclohexene by thionyl chloride
Kolodziejski, Waclaw; Delaude, Lionel ULg; Laszlo, Pierre ULg et al

in Applied Catalysis A : General (1993), 98(1), 71-79

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated ... [more ▼]

1-Methylcyclohexene was hydrochlorinated with SOCl2 to 1-chloro-1-methylcyclohexane at room temperature in CH2Cl2 as the solvent and in presence of the faujasitic zeolite ZF520 catalyst. 4-Coordinated framework aluminium in the parent sample coexisting with a small amount of immobile extra-framework aluminium at ca. -1 ppm is completely removed after just one reaction run and transformed into two distinct 6-coordinated species resonating at 0.2 and -3.1 ppm. The former line is assigned to Al(H2O)63+ cations, the latter is likely to come from a species with mixed solvation shells, probably Al(Cl-)(H2O)52+ and Al(OH-)(H2O)52+. Crystallinity of the catalyst is seriously affected by the reaction. The spectra confirm that before reaction the zeolite contains Si(3Si,1OH) and Si(2Si,2OH) groups. During the reaction most hydroxyl groups created by dealumination are removed, although some Si(3Si,1OH) remain. MAS NMR spectra are fully consistent with the proposed reaction mechanism. [less ▲]

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See detailEffect of androgen treatmen on fear reactions in ewes
Vandenheede, Marc ULg; Bouissou, M. F.

in Hormones & Behavior (1993), 27

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See detailOptimal Foraging By Hoverflies (Diptera, Syrphidae) And Ladybirds (Coleoptera, Coccinellidae) - Mechanisms
Hemptinne, Jl.; Dixon, Afg.; Doucet, Jean-Louis ULg et al

in European Journal of Entomology (1993), 90(4), 451-455

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines ... [more ▼]

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines in abundance before they mature. Optimal foraging theory predicts that such predators should lay a few eggs early in the development of an aphid colony. Studies on two species of coccinellid and one species of syrphid revealed that they do respond to the quality as well as the abundance of their prey. By refraining from laying eggs in aphid colonies already exploited by predators and those that are shortly to decline in abundance when the aphids disperse, these predators are able to forage in a way that is consistent with the predictions of optimal foraging theory. [less ▲]

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See detailLes pseudo-asthmes. Tout ce qui siffle n'est pas asthme.
CORHAY, Jean-Louis ULg; Bury, Thierry ULg; Cabut, Christian ULg et al

in Revue Médicale de Liège (1993), 48(3), 137-42

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See detailHigh Resolution Frequency Analysis as applied to the singing voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Folia Phoniatrica (1993), 45

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the ... [more ▼]

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the resonators. This is observed especially on a low fundamental, and it is acquired through technical skill and experience (2)Observation of the vibrato, which, isolated from the clinical study, regarding only its graphic presentation, could habe been interpreted as "abnormal". [less ▲]

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See detailThe Transcriptional Regulation of the Growth Hormone Gene Is Conserved in Vertebrate Evolution
Argenton, F.; Vianello, S.; Bernardini, S. et al

in Biochemical and Biophysical Research Communications (1993), 192(3), 1360-1366

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the ... [more ▼]

Growth hormone (GH) gene expression in mammals is regulated by the interaction of the transcription factor Pit-1 with two binding sites within the proximal promoter. Four sequences, homologous to the mammalian Pit-1 motif occur in the rainbow trout (Oncorhynchus mykiss) GHII (rtGH) gene promoter, two of which partly overlap. The three regions containing these putative Pit-1 binding sequences were protected from deoxyribonuclease I digestion by nuclear extracts of GC cells, a rat pituitary tumor cell line producing Pit-1. In gel shift assays, nuclear proteins from GC cells and from trout pituitaries were found to interact specifically with one of these protected sites. Transfection experiments showed that the rtGH promoter is transcnptionally active in GC cells, the response being strongly enhanced in the presence of a cAMP analogue. The results demonstrate that rat Pit-1 binds to and activates the rtGH promoter, indicating that the basic mechanisms regulating GH gene transcription have been conserved between fish and mammals. [less ▲]

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See detailLes morphinomimétiques en réanimation
Lamy, Maurice ULg; Joris, Jean ULg; Damas, Pierre ULg et al

in Réan urg (1993), 2(4bis), 488-494

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See detailComparative study of the body surface electrocardiogram in double-muscled and conventional calves.
Amory, Hélène ULg; Rollin, Frédéric ULg; Genicot, Bruno et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1993), 57(3), 139-45

The purpose of this work was to study electrocardiographic features of double-muscled beef cattle. Electrocardiograms were recorded on one to six occasions from each of a group of 18 conventional calves ... [more ▼]

The purpose of this work was to study electrocardiographic features of double-muscled beef cattle. Electrocardiograms were recorded on one to six occasions from each of a group of 18 conventional calves of the Friesian breed and 29 double-muscled calves of the Belgian White and Blue breed. Ages of the calves at the times of examination ranged from eight to 348 days. The Holmes semi-orthogonal lead system was used. The waves and interval durations and the tridimensional P, QRS, and T modal vector orientation and amplitude were calculated. The magnitude of the cardiac vectors was significantly lower and the ventricular waves and QT interval duration significantly shorter in the double-muscled than in the conventional calves. The P modal vector pointed significantly less downwards and the QRS modal vector pointed significantly more forwards and less up- and rightwards in the Belgian White and Blue, than in the Friesian group. Most of the observed differences might be a consequence of the bodily, and more specifically the thoracic, conformation of the former calves. However, the lower cardiac vector magnitude and shorter wave and interval durations might also reflect lower cardiac mass in the double-muscled subjects. [less ▲]

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See detailApplication de l'analyse fréquentielle à haute résolution
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Bulletin d'Audiophonologie (1993), IX(5), 490-497

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur ... [more ▼]

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur dans le placement de la voix dans les résonateurs. Il s'observe plus particulièrement sur un fondamental grave et s'acquiert par technique et expérience. 2. L'observation du vibrato, qu'il convient d'avoir vu avant, son observation graphique pourrait être considérée comme pathologique. [less ▲]

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See detailDifferent Mechanisms of Extracellular Matrix Remodeling by Fibroblasts in Response to Human Mammary Neoplastic Cells
Noël, Agnès ULg; Munaut, Carine ULg; Nusgens, Betty ULg et al

in Invasion & Metastasis (1993), 13(2), 72-81

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties ... [more ▼]

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties. They may also directly interact with collagen fibrils leading to retraction of the matrix. We have studied in vitro the influence of various human mammary tumor cells on the proliferation rate of normal human fibroblasts and on their level of collagen synthesis, as well as their release of collagenase activity. Interactions between neoplastic cells and collagen matrix were investigated by incorporation of tumor cells in collagen gels (lattices) and measurement of their retraction. All cells tested (HBL100, SW613, SA52, MDA-MB-231, MCF7, MCF7/6, MCF7 ras, BT20 and T47D) were able to modulate the composition of the extracellular matrix by one or several of the mechanisms investigated. Our results also demonstrate an opposite regulation of collagen and collagenase production. The effects on the collagen metabolism and on fibroblast proliferation are probably mediated by soluble cytokines since they are reproduced by incubating the fibroblasts in the presence of medium conditioned by tumor cells. The desmoplastic reaction may thus result from different mechanisms dependent upon tumor cell types. [less ▲]

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See detailMachine Intelligent Automatic Recognition of Critical Mobile Targets in Laser Radar Imagery
Delanoy, Richard L.; Verly, Jacques ULg; Dudgeon, Dan E.

in Lincoln Laboratory Journal (1993), 6(1), 161-186

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See detailTuméfaction de la jambe à Neocosmospora vasinfecta chez un transplanté rénal. Premier cas d'infection humaine
Chandenier, Jacques; Hayette, Marie-Pierre ULg; de Bièvre, Claude et al

in Journal de Mycologie Médicale (1993), 3

A 46-year old man, originated from Senegal, but living in France for more than 15 years, is dialized since January 1989, because of renal insuficiency. He had undergone a kidney graft in October 1990 with ... [more ▼]

A 46-year old man, originated from Senegal, but living in France for more than 15 years, is dialized since January 1989, because of renal insuficiency. He had undergone a kidney graft in October 1990 with good initial evolution, without any graft rejection. The immunosuppressive tretment quite moderate, was prenisone 10mg/d, azathioprine 50 mg/d and ciclosporine 400mg/d. On the 8th month, a tumefaction affecting the anterior side of the left leg was discovered, which was thick, renitent and non inflammatory. It relapsed after two punctures. In both cases direct examination showed numerous hyphae and a fungus identified as Neocosmospora vasinfecta, was isolated by culture:it is the sexual form of an Ascomycete whose species name is not identified. The treatment associated a complete surgery and ketoconazole during a week (200mg/d) The tumor did not relapsed after a 30 months follow up. [less ▲]

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See detailPotato chloroplasts express an intron-encoded maturase-like polypeptide
du Jardin, Patrick ULg; Portetelle, Daniel ULg; Harvengt, L. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101

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See detailLes stratégies de développement des villes européennes. Essai de bilan
Merenne-Schoumaker, Bernadette ULg

in Cahiers de Géographie du Quebec (1993), 37(100), 165-168

Reflections on new policies of the European cities for their development

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See detailPurification and Biochemical Characterization of Recombinant Human Placental Growth Hormone Produced in Escherichia Coli
Igout, Ahmed ULg; Van Beeumen, Jozef; Frankenne, Francis ULg et al

in Biochemical Journal (1993), 295(3), 719-724

The hGH-V (or hGH-2) gene codes for human placental growth hormone (hPGH). Secretion of hPGH is continuous, in contrast with the pulsed secretion of pituitary growth hormone (hGH) which it progressively ... [more ▼]

The hGH-V (or hGH-2) gene codes for human placental growth hormone (hPGH). Secretion of hPGH is continuous, in contrast with the pulsed secretion of pituitary growth hormone (hGH) which it progressively replaces in the maternal bloodstream. hGH- V cDNA has previously been cloned and isolated. Analysis of its nucleotide sequence has revealed a 191-residue protein, hPGH, differing from hGH at 13 positions. The calculated pI is more basic than that of the pituitary hormone. Here we have inserted hGH- VcDNA into the pIN-III-ompA3 plasmid in order to produce hPGH in its native form in Escherichia coli D1210. Expression of hGH- V cDNA in E. coli is significantly lower than that of hGH cDNA with the same expression system. The hPGH produced in E. coli was purified in quantities sufficient to allow its biochemical and immunochemical characterization. The molecular mass of the protein was determined by electrospray m.s. The determined mass, 22320 Da, agrees well with the molecular mass calculated from the translated cDNA sequence, assuming the presence of two disulphide bridges. Having established the technique for producing hPGH with a primary structure identical to the natural, non-glycosylated, 22 kDa isoform, we can now plan the full physicochemical and pharmaceutical characterization of this new hormonal entity. [less ▲]

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See detailApports récents de la génétique dans les maladies inflammatoires intestinales
Louis, Edouard ULg; Belaiche, Jacques ULg; Franchimont, D. et al

in Acta Clinica Belgica (1993), 48(6), 383-91

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the ... [more ▼]

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the concept of genetic heterogeneity. This new concept leads us to try to classify different forms of inflammatory bowel disease and could have in the future an impact on the prevention, the follow up and the treatment of these diseases. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailL'évaluation des effets de LOGO : un bilan vingt ans après ...
Denis, Brigitte ULg

in Revue de l'Organisation des Etudes (1993)

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See detailFacteurs écologiques de production du frêne en Condroz et productivité des stations potentielles
Claessens, Hugues ULg; Thibaut, André; Rondeux, Jacques ULg

in Cahiers Forestiers de Gembloux (1993), 11

The aim of the present study is to correlate site variables with measured site index restricted to pure even-aged or nearly even-aged stands of ash. The site evaluation has been made through 81 ... [more ▼]

The aim of the present study is to correlate site variables with measured site index restricted to pure even-aged or nearly even-aged stands of ash. The site evaluation has been made through 81 experimental plots distributed throughout the Condroz under a wide range of ecological conditions and types of soils. Site index (top height at 50 years) was measured on each plot using tree height-age relationship according to an appropriate methodology [THIBAUT and al., 1992]. In order to appreciate the relative importance of all the observed or measured site factors, plots were grouped in three major groups related to site conditions and defined as follows : alluvial and colluvial sites, flats and slopes either on deep muddy soils or on stony soils. Topographic position, soil depth and soil drainage conditions had the highest correlation with measured site index. These variables and the three site groups have been successfully used as independent variables in a regression model that is an interesting tool for evaluating productive potential of a site for ash even devoid of trees. [less ▲]

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See detailIntérêt du monitoring ambulatoire de la PA de 24 h en pratique quotidienne
Saint-Remy, Annie ULg; Rorive, Georges ULg

in Profil (1993)

L'avènement et les apports incontestablement positifs du monitoringe PA en ambulatoire ne remettent pas en question toutes les connaissances acquises depuis des décennies sur base de la PA mesurée ... [more ▼]

L'avènement et les apports incontestablement positifs du monitoringe PA en ambulatoire ne remettent pas en question toutes les connaissances acquises depuis des décennies sur base de la PA mesurée traditionnellement. On doit encore attendre des directives en matière de diagnostic et de thérapeutique. Une appréciation plus précise du statut tensionnel du patient, du type d'hypertension ainsi que du contrôle de PA pendant le nycthémère par les médications, constituent des avantages potentiels qui devraient sensibiliser les praticiens son utilisation. [less ▲]

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See detailEffects of Proglumide and Enprostil on Omeprazole-Induced Fundic Endocrine Cell Hyperplasia in Rats
Delwaide, Jean ULg; Latour, Pascale ULg; Gast, Pierrette ULg et al

in Gastroentérologie Clinique et Biologique (1993), 17(11), 792-6

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and ... [more ▼]

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and enprostil, a synthetic prostaglandin E2 derivative, might inhibit this hyperplasia. Six groups of 8 rats were treated for 10 weeks: a) untreated controls; b) omeprazole 10 mumol/kg; c) proglumide 500 mg/kg; d) enprostil 30 micrograms/kg; e) association of omeprazole and proglumide; f) association of omeprazole and enprostil. Serum gastrin levels were measured at different times during treatment. After sacrifice, fundic argyrophil cells were assessed by Grimelius' staining. Serum gastrin levels and argyrophil cell density were not modified in proglumide- and enprostil-treated groups, as compared with controls. Omeprazole increased significantly these two parameters. When given with omeprazole, proglumide decreased significantly serum gastrin levels and argyrophil cell density, as compared to omeprazole alone, while enprostil did not modify significantly these two parameters. These results indicate that proglumide, but not enprostil, can counteract the omeprazole-induced argyrophil cell hyperplasia in rats. [less ▲]

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See detailEngery-filtering transmission electron microscopy of biological specimens.
de Bruijn, W. C.; Sorber, C. W.; Gelsema, E. S. et al

in Scanning Microscopy (1993), 7(2), 693-708709

By energy-filtering transmission electron microscopy (EFTEM) electrons can be separated by their energy losses. An electron-energy filter, added to the microscope column allows the measurement of the ... [more ▼]

By energy-filtering transmission electron microscopy (EFTEM) electrons can be separated by their energy losses. An electron-energy filter, added to the microscope column allows the measurement of the energy distribution of transmitted electrons that have lost energy (< 2,000 eV, with an energy resolution of approximately 1 eV). These filtered electrons, recorded either as a spectrum or as an image, are composed of two parts superimposed on top of each other: (a) the unspecific energy-loss population (= the continuum) and (b) the specific element-related energy-loss population (= the edges). At the edges, electron data in spectra and images are mathematically processed, to obtain the desired element-related net-intensity values or images. These data are related to the total transmitted electron intensity, from the zero- and low-loss spectral region giving the relative spectralor image intensity rations ((S)R*x, (I)R*x), which can be related to the element concentration. The acquisition of the zero-loss and low-loss data is hampered by the restricted dynamic range of the TV camera. By improvements through the introduction of calibrated attenuation filters in the optical path to the TV-camera, more reliable values for (S)R*x and (I)R*x can be acquired. By addition of Bio-standards adjacent to the tissue, a "known" and "unknown" concentration of the element present in the same ultrathin section and the "bias" in the concentration estimation, can be obtained. Some practical examples are given for the estimation of the iron cencentration in siderosomes, boron in melasosomes and calcium in calcium oxalate monohydrate crystals. [less ▲]

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See detailCloning and characterization of G protein-coupled receptors
Parmentier, M.; Libert, F.; Perret, J. et al

in Advances in Second Messenger and Phosphoprotein Research (1993), 28

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See detailVidéographie à caractère historique : essai d'inventaire et Audiovisuel, histoire et enseignement : repères bibliographiques
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1993), 44e année(n°4),

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See detailMédiastinites: diagnostic, facteurs de risque et traitement
Medot, M.; Fissette, J.; Limet, Raymond ULg

in Annales de Chirurgie (1993), 47(8), 752-65

The authors review the literature concerning post-sternotomy mediastinitis. The incidence, mortality, diagnosis and risk factors are discussed, but above all, the various treatments are reviewed and ... [more ▼]

The authors review the literature concerning post-sternotomy mediastinitis. The incidence, mortality, diagnosis and risk factors are discussed, but above all, the various treatments are reviewed and compared with respect to their advantages and risks, their respective usefulness and results, in order to define a reasonable way of management of this highly pejorative surgical complication. Open technique, closed irrigation and surgical flaps of omentum, pectoralis major and rectus abdominis are successively considered. [less ▲]

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See detailBiostratigraphy and sequence stratigraphy at the Devonian-Carboniferous transition in southern China (Hunan Province); comparison with southern Belgium
Hance, Luc ULg; Muchez, P; Coen, M et al

in Annales de la Société Géologique de Belgique (1993), 116(2), 359-378

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See detailPolarization-corrected electrostatic potentials of aromatic compounds
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in Journal of the American Chemical Society (1993), 115(15), 6877-6882

The electrostatic potentials (EPS) corrected for polarization (TPS) of the aromatic compounds benzene, aniline, chlorobenzene, nitrobenzene, phenol, benzamide, and N-phenylacetamide have been calculated ... [more ▼]

The electrostatic potentials (EPS) corrected for polarization (TPS) of the aromatic compounds benzene, aniline, chlorobenzene, nitrobenzene, phenol, benzamide, and N-phenylacetamide have been calculated at the ab initio SCF level within three basis sets: 6-31G**, MINI-1, and STO-3G. For chlorobenzene in its MINI-1-optimized geometry, the calculation was also performed within MINI-1**. By reference to 6-31G**, the MINI-1-computed EP is much more satisfactory than the STO-3G-computed EP, whereas the MINI-I and STO-3G basis sets give very similar total potentials corrected for polarization (TPs). The MINI-1** basis set appears to be miscalibrated for computing EPs. It provides qualitative results that differ from those obtained with the 6-31G** basis set. The EP has a negative well above the middle of the benzene ring, while the TP exhibits a negative crown just above the benzene carbon atoms, where electrophilic attack takes place. The TP calculated for the interaction of nitrobenzene with a hydride ion instead of a proton allowed analyzation of the effects of polarization on the positive EP above the N-C bond. [less ▲]

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See detailMorphometric study of the stromal vascularization in peritoneal endometriosis.
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Anaf, Vincent et al

in Fertility and Sterility (1993), 59(3), 681-4

To evaluate the stromal vascularization of different appearances of peritoneal endometriosis, biopsies were taken from peritoneal areas with endometriosis in a series of 135 infertile women and classified ... [more ▼]

To evaluate the stromal vascularization of different appearances of peritoneal endometriosis, biopsies were taken from peritoneal areas with endometriosis in a series of 135 infertile women and classified as typical (black), red, or white lesions. The number of capillaries per mm2 of stroma, their mean surface area, and the ratio of capillaries/stroma surface area, and the mitotic activity were analyzed in typical, red, and white lesions. Significant differences were found between the different subgroups. The higher vascularization and mitotic activity observed in red lesions suggested the hypothesis that such lesions are very active and probably the first stage of early implantation of endometrial glands and stroma. The poor vascularization and the absence of mitosis observed in white lesions suggested that these lesions are much less active than red lesions and are a quiescent stage of the disease. Our study proves that the "activity" of peritoneal endometriosis is related to the vascularity. This concept must be considered in the further discussion of American Fertility Society Endometriosis Classification. Typical, red and white lesions are three different stages of the peritoneal disease and their relative relation to infertility is also probably different. [less ▲]

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See detailThe peripheral analgesic effects of opiods
Joris, Jean ULg; Hargreaves, Kenneth M

in APS Journal (1993), 2(1), 51-59

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See detailLa compétence du juge des référés en cas de procédure d'extradition
Kefer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1993)

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See detailLaparoscopic supracervical (subtotal) hysterectomy (LASH).
Donnez, Jacques; NISOLLE, Michelle ULg

in Journal of Gynecologic Surgery (1993), 9(2), 91-4

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which ... [more ▼]

The use of laparoscopically assisted vaginal hysterectomy with or without annexectomy has been widely discussed. We report the technique of laparoscopic supracervical (subtotal) hysterectomy (LASH), which was first performed in 1990. Laparoscopic supracervical hysterectomy was carried out in a series of 36 women. The duration time was 60 min in experienced hands. There were no major complications. The feasibility and low morbidity rate of this laparoscopic approach led us to propose LASH in certain indications, particularly in cases of a uterus with multiple submucosal myomas where hysteroscopic therapy is less successful. [less ▲]

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See detailSomatosensory potentials in dogs suffering naturally-acquired thoraco-lumbar spinal cord disease
Poncelet, Luc; Michaux, Ch.; Balligand, Marc ULg

in American Journal of Veterinary Research (1993)

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See detailPalynological age for the lower part of the Hangenberg Shales in Sauerland, Germany
Higgs, K; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1993), 116(Z), 243-247

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See detailIntercultural Education in French-speaking Belgium : an overview of ideology, legislation and practice
Martiniello, Marco ULg; Manço, Altay

in European Journal of Intercultural Education (1993), 4(2), 19-28

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See detailInteraction between the 67 kilodalton metastasis-associated laminin receptor and laminin.
Cioce, V.; Margulies, I. M.; Sobel, M. E. et al

in Kidney International (1993), 43(1), 30-7

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been ... [more ▼]

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been identified. In this study, the interaction between laminin and the high affinity metastasis-associated 67 kD laminin receptor (67 LR) was investigated by electron microscopy using the rotary shadowing technique. Laminin receptor that was purified from human colon carcinoma metastases appeared as a globular structure with a diameter of 5.2 +/- 0.8 nm. The 67 LR specifically bound to laminin on its long arm close to the intersection of the long and the short arms. There was no specific interaction of bovine serum albumin with laminin. Biochemical confirmation of the rotary shadowing experiments included slot blot solid phase assays in which [I125]-labeled 67 LR bound in a dose dependent manner to laminin as well as to the chymotrypsin resistant (C1) fragment of laminin that contains a short piece of the long arm. [I125]-labeled 67 LR did not bind to the pepsin resistant (P1) fragment of laminin that did not contain that segment on the long arm. This study therefore identifies the binding site on laminin for the 67 kD metastasis-associated laminin receptor as a region on the long arm of laminin close to the intersection of the four arms. [less ▲]

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See detailAssociation between the effacing (eae) gene and the Shiga-like toxin-encoding genes in Escherichia coli isolates from cattle
Mainil, Jacques ULg; Jacquemin, E.; Kaeckenbeeck, A. et al

in American Journal of Veterinary Research (1993), 54

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See detailKonie pociagowe ardenskie
Burny, Philippe ULg; Lebailly, Philippe ULg; Ensch, D. et al

in Przeglad Hodowlany (1993), (3/1993), 21-22

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See detailAnalyse de la viande de poulet par spectroscopie infrarouge proche.
Sindic, Marianne ULg; Chevalier, Olivier; Dardenne, Pierre et al

in Viandes et Produits Carnés (1993), 14(4),

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See detailEnhancement of metastatic potential of murine and human melanoma cells by laminin receptor peptide G: attachment of cancer cells to subendothelial matrix as a pathway for hematogenous metastasis.
Taraboletti, G.; Belotti, D.; Giavazzi, R. et al

in Journal of the National Cancer Institute (1993), 85(3), 235-40

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly ... [more ▼]

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly plays a crucial role in this event, the exact interactive pathways among cancer cells, laminin, and the vessel wall have not been elucidated. In a previous study, we identified synthetic peptide G, which contains the laminin-binding domain of the 67-kd laminin receptor and which inhibits tumor cell adhesion to endothelial cells. PURPOSE: To assess the role of the interaction between laminin and the 67-kd laminin receptor in hematogenous metastasis formation, we studied the effect of peptide G on melanoma cell behavior in vivo and in vitro. METHODS: The effect of peptide G and control peptides was studied in vivo on lung retention and colonizing potential of murine (B16BL6) and human (A2058) melanoma cells injected intravenously in C57BL/6 and nude mice, respectively. In addition, their effect on cell adhesion and chemotaxis to laminin and on binding of iodine 125-labeled laminin to cells was studied in vitro. RESULTS: In vivo, pretreatment of cells with peptide G resulted in a two- to 10-fold significant increase in the number of experimental lung metastases. A significant relative increase in lung retention of peptide G-treated tumor cells was observed 48 hours after injection, although after 4 hours a partial reduction was observed. In vitro, peptide G significantly increased laminin binding and cancer cell adhesion to laminin and subendothelial matrix, whereas chemotaxis to laminin was significantly inhibited. CONCLUSIONS: Peptide G differentially affected the biological response of cancer cells to laminin. In vitro, it increased laminin binding and cell adhesion to laminin and subendothelial matrix, whereas it inhibited cell chemotaxis to laminin. In vivo, the overall effect of peptide G was an augmentation of lung metastasis. IMPLICATIONS: Our findings suggest that direct adhesion of tumor cells to the subendothelial matrix is a main pathway for hematogenous metastases and that tumor cell-matrix interaction may be more relevant than tumor cell-endothelial cell attachment in this process. [less ▲]

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See detailIncreased Sister Chromatid Exchange Frequencies Observed in a Cohort of Inhabitants of a Village Located at the Boundary of an Industrial Dumping Ground: Phase I
Laurent, C.; Lakhanisky, T.; Jadot, P. et al

in Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology (1993), 2(4, Jul-Aug), 355-62

Since the mid-eighties, a sand pit located at the boundary of Mellery, a small village in Belgium, has been used as a dumping ground for industrial waste. After a particularly dry summer, many people ... [more ▼]

Since the mid-eighties, a sand pit located at the boundary of Mellery, a small village in Belgium, has been used as a dumping ground for industrial waste. After a particularly dry summer, many people complained of very foul smells coming from the dumping ground. An analysis of the environmental atmosphere detected alkanes and chlorinated saturated and unsaturated hydrocarbons in various concentrations. Consequently, the Belgian Ministry of the Environment requested additional measurements from the dumping site and the surrounding regions. Given the hazards and possible ill health effects associated with simultaneous exposure to low levels of many chemicals, biomarkers of personal exposure were measured in a representative group of people living in this village. The cytogenetic consequences of daily exposure to a mixture of genotoxicants were measured by the Sister Chromatid Exchange assay. The study included a group of 51 environmentally exposed persons (including 11 children) and 52 controls. A significant increase in Sister Chromatid Exchange frequency was detected among the inhabitants of the village compared to that of the control group, especially among the children living in Mellery as compared to the matched control children. [less ▲]

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See detailAtomic data and the spectrum of the solar photosphere.
Grevesse, Nicolas ULg; Noels-Grötsch, Arlette ULg

in Physica Scripta (1993), 47

Even though the solar photospheric abundances are now on the whole in very good agreement with the meteoritic values, some problems remain which will only be solved with a higher level of accuracy in the ... [more ▼]

Even though the solar photospheric abundances are now on the whole in very good agreement with the meteoritic values, some problems remain which will only be solved with a higher level of accuracy in the atomic data, especially the transition probabilities for faint lines. The authors justify this request for many more very accurate gf-values through a few particularly striking points. [less ▲]

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See detailFractionnement du froment d'hiver : influences variétale et phytotechnique.
Sindic, Marianne ULg; Chevalier, Olivier; Duculot, Jacqueline et al

in Industries des Céréales (1993), (82),

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See detailPour une didactique des sources audiovisuelles
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1993), 43e année(n°4), 11-13

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See detailNut van ambulante bloeddrukmeting bij arteriële hypertensie
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1993), 1

De frequentie van het 'witte-jassen' syndroom en het belang van dit fenomeen op de bloeddrukbelasting en de variabiliteit van de arteriële bloeddruk over 24 uur werden bij 181 patiënten onderzocht ... [more ▼]

De frequentie van het 'witte-jassen' syndroom en het belang van dit fenomeen op de bloeddrukbelasting en de variabiliteit van de arteriële bloeddruk over 24 uur werden bij 181 patiënten onderzocht gedurende een 24 uur durende ambulante bloeddrukmeting. Ondanks een goede correlatie tussen de klinische meting van de arteriële bloeddruk en de gemiddelde bloeddruk overdag of gedurende 24 uur, is er toch een tegenstrijdigheid tussen de .bloeddrukwaarden die met beide methoden worden gemeten (de klinische bloeddruk is hoger dan de ambulant gemeten bloeddruk, des te meer naarmate de klinische bloeddruk hoger is). Bij de beoordeling van de werkzaamheid van antihypertensiva blijkt uit het beloop van de bloeddruk dat een derde van de behandelde patiënten normale bloeddrukwaarden heeft, terwijl bij twee derden van de patiënten de gemiddelde bloeddruk overdag en gedurende 24 uur duidelijk hoger is dan per definitie is toegestaan. Dit onderzoek toont ook aan dat de ambulant gemeten bloeddrukwaarden (vooral de systolische bloeddruk) een beter voorspellend vermogen voor linker-ventrikelhypertrofie hebben dan de klinisch gemeten bloeddrukwaarden. Deze waarnemingen bevestigen het belang van deze niet-invasieve techniek van meting van de gemiddelde bloeddruk, zowel om het 'witte-jassen' effect te objectiveren en aldus de diagnose arteriële hypertensie te preciseren, als om na te gaan of de bloeddruk met antihypertensiva goed is ingesteld. [less ▲]

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See detailTEM investigation of transition phases precipitation in ZA alloys after isothermal aging at 250°C and subsequent creep at high temperature
Lecomte-Beckers, Jacqueline ULg; Terziev, L.; Wegria, J.

in Materials Science Forum (Intergranular and Interphase Boundaries in Materials) (1993), 126-128

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ... [more ▼]

Transition phases occurring during isothermal aging at 250°C af ternary Zri-A1-Cu alloys are modlifîed after creep at high temperature. fle pressure applkd during creep leads to a high dertsity of clef ects which modifies the ndcrostructure. 11e trnsitiôn phases are studied by me ans of transmission electron microscopy and diffraction technique. Œ’r and phases pile up on dislocations. 11e reaction «s + £ 4 T +r 1$ accelerated and the transition T’ -. e’ is proxnoted by the defects. [less ▲]

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See detailAn overview of the kinetic parameters of class B beta-lactamases.
Felici, A; Amicosante, G; Oratore, A et al

in Biochemical Journal (1993), 291 ( Pt 1)

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme ... [more ▼]

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme. The A. hydrophila beta-lactamase exhibited a unique specificity profile and could be considered as a rather specific 'carbapenemase'. No relationships were found between sequence similarities and catalytic properties. The problem of the repartition of class B beta-lactamases into sub-classes is discussed. Improved purification methods were devised for the P. maltophilia and A. hydrophila beta-lactamases including, for the latter enzyme, a very efficient affinity chromatography step on a Zn(2+)-chelate column. [less ▲]

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See detailConditional heteroscedasticity in pacific-basin stock market returns
Corhay, Albert ULg; Tourani-Rad, Alireza

in Research in International Business and Finance (1993), 10

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return ... [more ▼]

This paper examines the statistical behavior of daily stock returns in several Pacific-Basin stock exchanges, which have grown tremendously in recent years. Empirical evidence reveals that return-generating models which empirically fit the data are processes with conditional heteroscedastic innovations. Particularly, the generalized autoregressive conditional heteroscedastic GARCH(1,1) process turns out to be the best in most cases. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1993), n°1

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See detailLe traitement des adénomes à prolactine : utilisation d'un nouvel agoniste dopaminergique à longue durée d'action, la cabergoline, chez 56 patients
Beckers, Albert ULg; Abs, R.; Demez, Pierre ULg et al

in Médecine et Hygiène (1993), 51(1990), 1978-1980

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de ... [more ▼]

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de macroadénome dans 21 cas ont été traités durant des périodes variant entre 1 et 17 mois à des doses de cabergoline variant entre 0,25 mg et 2 mg par semaine, prises à raison de 1 à 4 fois par semaine. Cette nouvelle substance nous est apparue extrêmement efficace et très bien tolérée [less ▲]

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See detailHigh-Grade Pleomorphic T Cell Lymphoma with Restricted Involvement of Skin and Bone Marrow
Gautier, M. S.; Pierard, Gérald ULg; Andrien, Francine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(4), 287-9

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this ... [more ▼]

Pleomorphic T cell lymphoma of the medium to large cell type expressing CD30 antigen is a most aggressive peripheral T cell lymphoma. Currently, there is no satisfactory treatment available for this neoplasm. We report the case of a woman with prominent skin and bone marrow involvement without detectable lymph node localization. This unusual presentation of disease responded well to polychemotherapy combined with autologous bone marrow transplantation. [less ▲]

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