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See detailRelationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major.
Cazzola, M.; De Stefano, P.; Ponchio, L. et al

in British Journal of Haematology (1995), 89(3), 473-8

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion ... [more ▼]

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion regimen and suppression of erythropoiesis in 52 patients with beta-thalassaemia major whose mean pretransfusion haemoglobin levels ranged from 8.6 to 10.9 g/dl. Multiple, regression analysis showed that serum transferrin receptor was the parameter more closely related to mean pretransfusion haemoglobin (r = -0.77, P < 0.001). As measured through serum transferrin receptor, erythroid activity was 1-2 times normal for pretransfusion haemoglobin levels between 10 and 11 g/dl. 1-4 times normal for levels from 9 to 10 g/dl, and 2-6 times normal for levels from 8.6 to 9 g/dl. Mean pretransfusion haemoglobin was also inversely related to serum erythropoietin (r = -0.72, P < 0.001), whereas it showed no or a weak relationship with Hb F, reticulocyte count, or circulating nucleated red cell count. This study suggests that serum transferrin receptor is a reliable indicator of suppression of erythropoiesis in beta-thalassaemia major. On the basis of our findings, pretransfusion haemoglobin values of < or = 9 g/dl should be adopted with caution, because these levels can be associated with an insufficient inhibition of erythroid marrow expansion. However, a transfusion programme, with a baseline haemoglobin of 9-10 g/dl, may provide enough suppression of erythropoiesis and allow a reduction in blood consumption as compared with the classic hyper- or supertransfusion schemes. Since fixed haemoglobin levels may not be the best target for transfusion treatment in all thalassaemic patients, assay of serum transferrin receptor may be helpful for individualizing the transfusion regimens. [less ▲]

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See detailFinite-amplitude regimes of the short-wave Marangoni-Benard convective instability.
Colinet, Pierre; Legros, Jean-Claude; Kamotani, Y. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(3), 2603-2616

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See detailPost-operative erythropoiesis is limited by the inflammatory effect of surgery on iron metabolism.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1995), 25(6), 383-9

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible ... [more ▼]

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible diseases has led to the restrictive use of homologous blood and to interest in alternatives for correcting anaemia. We investigated the pathophysiology of postoperative anaemia by studying variables of erythropoiesis, iron metabolism, and inflammation in 48 consecutive patients who underwent total hip replacement. Haemoglobin concentration remained low during 14 days after surgery with only a mild increase in erythropoietin concentration and reticulocyte count. No increase in serum transferrin receptor concentration was observed during the first 2 weeks after surgery. Postoperative serum ferritin increased, whereas serum iron, transferrin and transferrin saturation decreased significantly. There was a marked increase in interleukin-6 and C-reactive protein with maximal values on the 1st and 4th post-operative day, respectively. At 6 weeks after surgery, haemoglobin concentration and variables of iron metabolism were almost at the preoperative level and serum transferrin receptor concentration was significantly increased, indicating increased erythropoietic activity. These changes were preceded by the normalization of interleukin-6 and C-reactive protein levels. Haemoglobin, iron, transferrin, and ferritin concentrations were not influenced by iron therapy during the postoperative period and no differences of erythropoietic and iron variables were observed between transfused and non-transfused patients. In conclusion, post-operative erythropoiesis is associated with an inflammatory effect of surgery on iron metabolism, which can explain, despite a slightly increased production of erythropoietin, the persistence of anaemia and the lack of effect of iron supplementation after surgery. [less ▲]

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See detailAcquired Persistent Atypical Lentigines as a Failure of 5-Methoxypsoralen-Containing Sunscreens in the Photochemoprotection from Ultraviolet-Radiation-Induced Damage
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Nikkels, Arjen ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 338-340

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing ... [more ▼]

Acquired persistent atypical lentigines are pigmentary lesions that are unusual both clinically and microscopically. They occur in young adults with photosensitive skin using 5-methoxypsoralen-containing sunscreens during sunbathing. Their biologic behavior is benign, but there are grounds for concern regarding the carcinogenic risk in these patients. [less ▲]

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See detailSpécificités cardio-respiratoires de la médecine sportive équine
Lekeux, Pierre ULg; Art, Tatiana ULg

in Médecine du Sport (1995), 69

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See detailIndice plasmodique et parasitémie à Plasmodium falciparum: valeur diagnostique et pronostique au Congo.
Carme, B.; Hayette, Marie-Pierre ULg; Mbitsi, A. et al

in Annales de la Société Belge de Médecine Tropicale (1972) (1995), 75

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the ... [more ▼]

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the intention of establishing diagnosis and prognosis value of Plasmodium falciparum parasitaemia in areas with high perennial transmission. In such an area Congolese school children (6-10 years old) had 88% P. falciparum index, this is the same percentage as that for children hospitalized with a pernicious attack. However, the parasite load is distributed differently; parasitaemia is greater than 6,000 asexual form for P. falciparum (af/Pf/µl) in only 4,6% of cases in the former group, versus 67% in the second group. A threshold of 10,000 af/Pf/µl above which the Plasmodium infection triggers a febrile attack in semi-immune children, is confirmed in school children in a rural context where the factor of taking antimalarial drugs within the preceding days is negligible: three out of four children with levels above this threshold are febrile versus 4,1% (7 out of 170) with lower blood parasite levels. Some adults where also asymptomatic carriers but much less frequently and with lower mean parasitaemia levels. The parasite load mirrors the clinical severity although this concept can be misleading as an individual prognostic criterion and foor hospital studies carried out in areas where multiple drug administration before hospitalization is common. For the studies recently performed in Brazzaville, the 5% threshold of parasitized red cells, the WHO severity criterion was never reached in asymptomatic subject or in cases of simple attack; it was reached in one out of two cases of pernicious attack. [less ▲]

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See detailEffects of iproflavone and its metabolites on human articular chondrocytes
Bassleer, Corinne; Franchimont, Paul; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1995), 4

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See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

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See detailOxidation of organic substrates with potassium ferrate (VI) in the presence of the K10 montmorillonite
Delaude, Lionel ULg; Laszlo, Pierre ULg; Lehance, Pascal

in Tetrahedron Letters (1995), 36(46), 8505-8508

Among various aluminosilicate supports, the K10 montmorillonite clay was the best catalyst for the oxidation of organic substrates with potassium ferrate (VI). Thus, a solid mixture of K2FeO4 and K10 has ... [more ▼]

Among various aluminosilicate supports, the K10 montmorillonite clay was the best catalyst for the oxidation of organic substrates with potassium ferrate (VI). Thus, a solid mixture of K2FeO4 and K10 has been used for the efficient oxidation of selected alcohols, benzylamine, thiophenol, and aniline in hydrocarbon solvents at room temperature. Somewhat humid clay performs best, and it is important to control the amount of water associated to the solid support. [less ▲]

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See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

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See detailEtude de la variabilité interindividuelle des potentiels evoques auditifs exogènes et endogènes en condition d'attention volontaire
Lembreghts, M.; Crasson, Marion ULg; el Ahmadi, A. et al

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(4), 203-23

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we ... [more ▼]

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we recorded 86 control subjects, using an auditory oddball paradigm with motor response. We analyzed the successive components of the ERP's evoked by target and standard stimuli (N1, P2, N2, P3a, P3b and slow wave negativity). Our results underlined the role of age, sex and psychological factors on the ERP's interindividual variability: P3 amplitude decreased and its latency increased with age, while its topography was more frontal in the older than in the younger subjects. The P300 occurrence after standard stimuli and P3 amplitude after target stimuli were different according to sex. Moreover, P300 amplitude, latency and topography were related to the subject's anxiety level. Finally, our results also propose new description modes of ERP's relying on P3a and P3b relative peak amplitude (P300 with prominent P3a or P3b), topographical predominance (frontal or parietal P300) and duration of the late positive complex (brief or long-lasting P300). These data will improve the clinical use of P300. [less ▲]

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See detailTémoignages de la spiritualité néolithique au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailA Frequency-Domain Processor for ScanSAR Images
Barbier, Christian ULg; Rosello-Guasch, Josep

in Preparing for the Future (1995), 5(4), 6-7

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See detailThe flesinoxan 5-HT1A receptor challenge in major depression and suicidal behavior.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Pharmacopsychiatry (1995), 28 Suppl 2

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature ... [more ▼]

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature responses to flesinoxan, a5-HT1A agonist, in 30 DSM-III-R major depressed inpatients subgrouped into suicide attempters (n = 15) and nonattempters (n = 15). The patients were assessed after a drug-free period of at least 3 weeks. A subsample of 16 patients completed the Buss-Durkee Hostility Inventory as a measure of impulsive aggressive behavior. Mean delta cortisol responses to flesinoxan were significantly lower in the group of depressed patients with a history of suicide attempts than in the group without history of suicidal behavior: for the delta cortisol values 14.5 +/- 16.3 micrograms/l vs 101 +/- 94 micrograms/l (F = 8.9, df = 5.25, p = 0.006). There was also a very significant difference between suicide attempters and nonattempters for the temperature (delta T degrees) responses to flesinoxan: 0.20 +/- 0.24 degrees C vs. 0.60 +/- 0.24 degrees C (F = 18.1, df = 5.25, p = 0.0003). Hormonal and temperature responses to flesinoxan were not correlated with BDHI irritability or assault subscale scores. The results of the present study support the implication of the serotonergic system, particularly 5-HT1A receptors, in the control of self-directed aggressive behavior. Moreover, in depressed patients, serotonergic abnormalities do not appear to be related to aggressive behavior. [less ▲]

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See detailCytokines and cartilage degradation
Henrotin, Yves ULg; De Groote, D; Labasse, A et al

in Mediators of Inflammation (1995), 4

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See detailLa naissance de l'écriture au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailLes insuffisances mitrales ischémiques: principes de leur traitement chirurgical
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 295-7

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou ... [more ▼]

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou chroniques de la maladie ischémique. Leur compréhension est facilité par la classification fonctionnelle de Carpentier. A l'occasion de cette revue, nous précisons les indications elles modalités de traitement de ce type d'insuffisance mitrale. [less ▲]

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See detailCryptocrine Signaling in the Thymus Network and T Cell Education to Neuroendocrine Self-Antigens
Geenen, Vincent ULg; Goxe, Béatrice; Martens, Henri ULg et al

in Journal of Molecular Medicine : Official Organ of the 'Gesellschaft Deutscher Naturforscher und Ärzte' (1995), 73(9), 449-55

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental ... [more ▼]

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental observations which support a dual role in T cell selection played by the thymic repertoire of neuroendocrine polypeptide precursors. Through the mode of cryptocrine intercellular signaling thymic neuroendocrine-related precursors synthesized in thymic epithelial cells have been shown to influence the early steps in T cell differentiation. In addition, thymic neuroendocrine-related polypeptides are a source of self-antigens which are presented by the major histocompatibility system of the thymic epithelium. Preliminary data also suggest that the intrathymic T cell education to neuroendocrine self-antigens is not strictly superimposible to the antigen presentation by dedicated presenting cells. Insulin-like growth factor-II (IGF-II) was identified as one dominant member of the insulin family expressed by thymic epithelial and nurse cells. The intrathymic presentation of IGF-II or IGF-II derived self-antigens is under current investigation. If further confirmed, the central tolerogenic properties of IGF-II could be considered in the elaboration of a strategy for an efficient and safe prevention of insulin-dependent diabetes. [less ▲]

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See detailCytotoxicity towards human endothelial cells, induced by neutrophil myeloperoxidase: protection by ceftazidime.
Mathy, Marianne ULg; Deby, Ginette ULg; Deby, C. et al

in Mediators of Inflammation (1995), 4(6), 437-43

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system ... [more ▼]

We investigated the effects of the antibiotic ceftazidime (CAZ) on the cytolytic action of the neutrophil myeloperoxidase-hydrogen peroxide-chloride anion system (MPO/H(2)O(2)/Cl(-)). In this system, myeloperoxidase catalyses the conversion of H(2)O(2) and CI(-) to the cytotoxic agent HOCl. Stimulated neutrophils can release MPO into the extracellular environment and then may cause tissue injury through direct endothelial cells lysis. We showed that human umbilical vein endothelial cells (HUVEC) were capable of taking up active MPO. In presence of H(2)O(2) (10(-4) M), this uptake was accompanied by cell lysis. The cytolysis was estimated by the release of (51)Cr from HUVEC and expressed as an index of cytotoxicity (IC). Dose dependent protection was obtained for CAZ concentrations ranging from 10(-5) to 10(-3) M;this can be attributed to inactivation of HOCl by the drug. This protection is comparable to that obtained with methionine and histidine, both of which are known to neutralize HOCl. This protection by CAZ could also be attributed to inactivation of H(2)O(2), but when cytolysis was achieved with H(2)O(2) or O(2) (-) generating enzymatic systems, no protection by CAZ was observed. Moreover, the peroxidation activity of MPO (action on H(2)O(2)) was not affected by CAZ, while CAZ prevented the chlorination activity of MPO (chlorination of monochlorodimedon). So, we concluded that CAZ acts via HOCl inactivation. These antioxidant properties of CAZ may be clinically useful in pathological situations where excessive activation of neutrophils occurs, such as in sepsis. [less ▲]

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See detailIn vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide
Ezzat, S.; Kontogeorgos, G.; Redelmeier, D. A. et al

in European Journal of Endocrinology (1995), 133

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See detailLes confraternités de l'abbaye de Stavelot-Malmedy
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1995), CLXI

réseau de fraternités de Stavelot-Malmdy mis en parallèle avec tous les échanges humains observés dans toutes les sources

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See detailFactors regulating megakaryocyte progenitor commitment to polyploidization.
Paulus, Jean-Michel ULg; Grosdent, J C; Prenant, M et al

in Comptes Rendus de l'Académie des Sciences. Série III. Sciences de la Vie (1995), 318(3), 381-6

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms ... [more ▼]

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms of megakaryocytes determined by microphotometric or flow cytometric measurements of megakaryocyte DNA have generally been used. However these techniques provide no information on the rate of commitment of CFU-MKC to polyploidy. Using a technique of clonal analysis determining the distributions of the number of doublings (NbD) undergone by CFU-MKC before committing to polyploidization, the polyploidization probability of CFU-MKC could be derived. This probability was found to be a constant independent from CFU-MKC mitotic history, since NbD distributions are exponential functions characterized by a constant rate of decay per doubling. By studying the effects of growth factors on polyploidization probability, it was also shown that: (1) this parameter is negatively regulated by growth factors contained in poke-weed or WEHI conditioned media, as well as by erythropoietin; (2) commitment to polyploidization does not require prior CFU-MKC division; (3) bipotent erythroid-megakaryocyte progenitors have a lower polyploidization probability than CFU-MKC; (4) determination of polyploidization probability reflects the activity of growth factors with greater accuracy than megakaryocyte colony count. [less ▲]

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See detailBiopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Evrard, Brigitte ULg; Delahaut, P.; Hubert, Philippe ULg et al

in Journal of Controlled Release (1995), 35

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the ... [more ▼]

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the rate constant for elimination (ke) for the intravenous solution was 0.18 h−1 compared to 0.10 h−1 for the oral aqueous solution. The absolute bioavailability of the oral solution was about 75%. A lipid matrix containing SMZ and a high density excipient is able to be retained in the reticulo-rumen and to produce a sustained release of the drug for at least 100 h provided that the mechanical strength of the bolus is sufficient. The pharmacokinetic data obtained with the lipid matrix show a release profile with two pulses due to both diffusion and erosion mechanisms. Plasma levels are maintained above the MIC of SMZ during 100 h with an absolute bioavailability of 51.7% [less ▲]

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See detailNF-kappaB transcription factor activation by hydrogen peroxide can be decreased by 2,3-dihydroxybenzoic acid and its ethylester derivative
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in Archives of Biochemistry & Biophysics (1995)

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See detailSoya oil in diet for growing-fattening bulls: I. Effects on animal performances and carcass composition
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Dufrasne, Isabelle ULg et al

in Journal of Animal Physiology & Animal Nutrition (1995), 74

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See detailHydroxychloroquine (Plaquenil) for recurrence prevention of Crohn's disease after curative surgery.
Louis, Edouard ULg; Belaiche, Jacques ULg

in Gastroentérologie Clinique et Biologique (1995), 19(2), 233-4

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See detailÉvaluation de l’impact de la végétation sur le rayonnement énergétique (aide à la conception architecturale et urbanistique)
Teller, Jacques ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailRegulation Of The Beta-Lactamase Blal Of Streptomyces-Cacaoi - The Product Of The Blab Regulatory Gene Is An Internal Membrane-Bound Protein
Magdalena, J.; Joris, Bernard ULg; Vanbeeumen, J. et al

in Biochemical Journal (1995), 311

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open ... [more ▼]

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open reading frames, ORF1 (blaA) and ORF2 (blaB) [Lenzini, Magdalena, Fraipont, Joris, Matagne and Dusart (1992) Mol. Gen. Genet. 235, 41-48]. BlaA belongs to the LysR family of transcription activators, whereas BlaB shares some features with the penicillin-recognizing proteins. BlaB has now been overexpressed in Escherichia coli, purified and used for antibody preparation. Immunoblotting of cell-fractionated materials from S. cacaoi showed that BlaB is attached to the internal face of the cytoplasmic membrane. It could not be released by high salt concentrations or EDTA, but only by protease treatment. Under the assay conditions, BlaB did not act as a penicillin-binding protein, a beta-lactamase, a D-amino-peptidase or a target in a phosphorylation step. [less ▲]

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See detailTwo forms of lipase from Mucor miehei exhibit a different behavior at the air-water interface.
Blecker, Christophe ULg; Razafindralambo, Hary ULg; Paquot, Michel ULg et al

in Colloids and Surfaces B : Biointerfaces (1995), (3), 271-279

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See detailStudies On The In-Situ Nitrogen Degradability Corrected For Bacterial-Contamination Of Concentrate Feeds In Steers
Beckers, Yves ULg; Thewis, André ULg; Maudoux, B. et al

in Journal of Animal Science (1995), 73(1), 220-227

Stable 15N was used to evaluate the influence of bacterial contamination on in situ DM and N degradabilities (Dg) of meat and bone meal (MBM), soybean meal (SBM), and wheat bran (WB) in two steers ... [more ▼]

Stable 15N was used to evaluate the influence of bacterial contamination on in situ DM and N degradabilities (Dg) of meat and bone meal (MBM), soybean meal (SBM), and wheat bran (WB) in two steers. Bacterial DM and N contamination ranged from 2.4 to 28.6% and 2.1 to 56.8% of residual DM and N, respectively. Effective N degradability increased when bacterial contamination was taken into account ( P < .05). The difference was low for MBM (2.4%) and for SBM (3.4%) but high for WB (12.2%). Theoretically, using solid-associated bacteria should give the most accurate correction for bacterial contamination; however, results showed that Dg of N based on liquid-associated bacteria were identical for MBM and SBM ( P > .05) and different for WB ( P .05). In a second experiment, five treatments were applied to incubated feeds to remove bacteria fxed to the residues and consequently to determine directly the Dg of DM and N corrected for the bacterial contamination without the need for a marker. These treatments involved chilling for 6 h at 4°C in saline solution alone ( T l ) or with a commercial detergent (T2), or with sodium dodecyl sulfate (T3) or with methylcellulose (T4), followed by pummeling in a stomacher for 5 min. The last treatment was only machine washing twice (T5). The Dg of DM can be directly determined following the first four treatments, nevertheless their application to MBM and SBM led to higher Dg of N than that corrected for the bacterial contamination determined in the frst experiment ( P < .05). This overestimation was higher than the observed underestimation when the correction for bacterial contamination was omitted. However, two treatments (T1 and T4) were able to dislodge bacterial N fixed to incubated WB and so the Dg of N could be measured directly. In conclusion, bacterial contamination of concentrate feeds incubated in the rumen may be extensive. In this case Dg must be corrected for this contamination or treatments for decontamination can be applied to residues before determining the Dg of N. [less ▲]

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See detailINTERVALENCE TRANSITIONS IN MIXED-VALENCE BIS(TETRATHIAFULVALENE) COMPOUNDS
Lahlil, Khalid; Moradpour, Alec; Bowlas, Christopher et al

in Journal of the American Chemical Society (1995), 117(40), 9995-10002

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds ... [more ▼]

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds exhibit four reversible sequential one-electron oxidation steps, on the basis of cyclic voltammetry. For the cation radicals 7b(.+), 10(.+), and 12(.+), generated electrochemically, rather intense and broad bands in the near-IR region, specific of class II mixed valence compounds, were found. Theoretical calculations at the semiempirical AM1 level as well as at the ab-initio level indicated that these cation radicals are charge-distributions localized as related to mixed valence species. These calculations also allowed the low-energy absorption bands to be assigned to intervalence transitions; these transitions imply the existence of multiple low-lying excited states that are non-adiabatically coupled to the ground-state of these open-shell species. [less ▲]

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See detailAttitudes d’enfants de 6 à 12 ans à l’égard de l’éducation physique scolaire et de ses objectifs
Delfosse, Catherine; Cloes, Marc ULg; Ledent, Maryse et al

in Sport (1995), 149(1), 35-49

L'organisation d'une séance quotidienne d'éducation physique dans l'enseignement fondamental a longtemps été revendiquée par les professionnels de l'éducation physique. Des expériences déjà anciennes ... [more ▼]

L'organisation d'une séance quotidienne d'éducation physique dans l'enseignement fondamental a longtemps été revendiquée par les professionnels de l'éducation physique. Des expériences déjà anciennes augmentant la quantité d'activité physique - heure quotidienne, mi-temps ou tiers-temps pédagogiques - ont mis en évidence quelles applications pourraient être bénéfiques pour les enfant, surtout sur des aspects en relation avec les qualités physiques. ... [less ▲]

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See detailAller voir ailleurs si j'y suis. Hergé, Michaux, Simenon
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (1995), (12), 121-136

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See detailNucleic acid compartmentalization within the cell nucleus by in situ transferase-immunogold techniques.
Thiry, Marc ULg

in Microscopy Research and Technique (1995), 31(1), 4-21

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is ... [more ▼]

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is placed on the various nucleolar components and the various enigmatic structures of the extranucleolar region: interchromatin granules, coiled bodies, and simple nuclear bodies. These data are discussed in the light of our current understanding of the functional organization of the cell nucleus. [less ▲]

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See detailSynthesis And Antimicrobial And Toxicological Studies Of Amino-Acid And Peptide Derivatives Of Kanamycin-A And Netilmicin
Kotretsou, S.; Mingeotleclercq, Mp.; Constantinoukokotou, V. et al

in Journal of Medicinal Chemistry (1995), 38(23), 4710-9

Amino acid and peptide derivatives of aminoglycosides have been obtained by substitution of the 1-N or 6'-N amino functions of kanamycin A and netilmicin via the temporary complexation of vicinal and ... [more ▼]

Amino acid and peptide derivatives of aminoglycosides have been obtained by substitution of the 1-N or 6'-N amino functions of kanamycin A and netilmicin via the temporary complexation of vicinal and nonvicinal amino and hydroxy functions by copper ion [1-N kanamycin A derivatives: L-Ala (6a), D-Ala (6b), Gly (6c), L-Asp (6d), L-Ala-L-Ala (6e). 6'-N kanamycin A derivatives: L-Ala (3a), D-Ala (3b), Gly (3c), L-Ala-L-Ala (3e), L-Leu (3f). 6'-N netilmicin derivatives: L-Ala (9a), D-Ala (9b), Gly (9c), L-Asp (9d), L-Ala-L-Ala (9e)]. Characterization was made by FAB-MS, IR, 1H-NMR, and 13C-NMR. All derivatives were essentially inactive. The nephrotoxic potential of the derivatives obtained in sufficient quantities (3b,e and 9a-e) was assessed by measuring their inhibitory potential toward the activity of lysosomal phospholipase A1 acting on phosphatidylcholine embedded in negatively-charged membranes. One compound, 6'-N-L-Ala-netilmicin (9a), showed a 2-fold decrease of inhibitory potency compared to its parent drug. A conformational analysis revealed that it adopts two equally probable conformations and orientations when interacting with phosphatidylinositol. The first in which the drug lies parallel to the hydrophobic-hydrophilic interface, is similar to that of netilmicin. The second, in which the drug inserts itself in the bilayer across the hydrophilic/hydrophobic interface, is similar to that described for streptomycin, an almost non-nephrotoxic aminoglycoside. [less ▲]

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See detailThe pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain.
Peers, Bernard ULg; Sharma, S.; Johnson, T. et al

in Molecular & Cellular Biology (1995), 15(12), 7091-7

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most ... [more ▼]

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most homeodomain proteins bind indiscriminately to potential target sites in vitro, suggesting the involvement of cofactors which specify target site selection. One such cofactor, termed extradenticle, has been shown to influence segmental morphogenesis in Drosophila melanogaster by binding cooperatively with certain homeodomain proteins to target regulatory elements. Here we demonstrate that STF-1, an orphan homeodomain protein required for pancreatic development in mammals, binds cooperatively to DNA with Pbx, the mammalian homolog of extradenticle. Cooperative binding with Pbx requires a pentapeptide motif (FPWMK) which is well conserved among a large subset of homeodomain proteins. The FPMWK motif is not sufficient to confer Pbx cooperativity on other homeodomain proteins, however; the N-terminal arm of the STF-1 homeodomain is also essential. As cooperative binding with Pbx occurs on only a subset of potential STF-1 target sites, our results suggest that Pbx may specify target gene selection in the developing pancreas by forming heterodimeric complexes with STF-1. [less ▲]

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See detailInter-individual variability of teachers' feedback: Study in simulated teaching conditions
Cloes, Marc ULg; Denève, Alain; Piéron, Maurice ULg

in European Physical Education Review (1995), 1(1), 83-93

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à ... [more ▼]

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à la prestation se caractérisent par une grande variabilité interindividuelle. Leur émission fait suite à un processus comportant deux phases: le diagnostic et la prescription. Afin de mettre en évidence le rôle exercé par les facteurs liés aux caractéristiques de l'enseignant sur celles de leurs interventions, nous avons comparé les réactions à la prestation émises par 12 éducateurs physiques lors d'une séance d'enseignement simulé. Grâce à cette technique vidéo, les sujets réagissent à partir de performances motrices identiques. Les feedback ont été comparés entre quatre groupes de sujets caractérisés par des niveaux d'expérience sportive et pédagogique similaires. Une analyse factorielle par correspondance a permis d'identifier des classes de sujets émettant des feedback de même type. Les résultats tendent à souligner que (1) le niveau d'expertise dans la pratique de l'activité enseignée exerce une influence sur la première de ces phases; (2) le degré d'expertise pédagogique contribue à améliorer l'émission du message. [less ▲]

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See detailExégèse de Paul. D. 39,3 (de aqua et aquae pluviae arcendae), 2,6
Gerkens, Jean-François ULg

in Tijdschrift voor Rechtsgeschiedenis (1995), 63(1995/1), 11-26

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See detailAspects hémodynamiques de l'insulinorésistance: des concepts théoriques à la thérapeutique.
Paquot, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1995), 53

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See detailRectovaginal septum, endometriosis or adenomyosis: laparoscopic management in a series of 231 patients.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1995), 10(3), 630-5

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases ... [more ▼]

A series of 231 cases of deep-infiltrating endometriosis of the rectovaginal septum is presented. Laparoscopic procedures with excision of deep fibrotic endometriotic nodules were performed in all cases. In three cases, the bowel lumen was entered. No other peri-operative complications were observed. Three cases of urinary retention were reported. The nodule resection resulted in considerable pain relief. Histologically, the rectovaginal nodule was similar to an adenomyoma. Indeed it was a circumscribed nodular aggregate of smooth muscle and endometrial glands. This form of disease must be considered as a specific disease which originates from the Mullerian rests present in the rectovaginal septum and we suggest that it be called 'rectovaginal adenomyosis'. [less ▲]

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See detailNF-kappaB transcription factor and human immunodeficiency virus type 1 (HIV-1) are activated by methylene blue photosensitization
Piret, Bernard; Legrand-Poels, Sylvie ULg; Sappey, Christine et al

in European Journal of Biochemistry (1995)

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See detailHIV-1 and NF-kappaB activation by photo-oxidative stress
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg; Piret, Bernard

in Photochemistry & Photobiology (1995)

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See detailFoie et maladies inflammatoires du tube digestif
Belaiche, Jacques ULg; Houbiers, G.; Louis, Edouard ULg

in Médecine et Hygiène (1995), 53

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See detailIron chelation decreases NF-kappaB and HIV-1 activation due to oxidative stress
Sappey, Christine; Boelaert, J. R.; Legrand-Poels, Sylvie ULg et al

in AIDS Research and Human Retroviruses (1995)

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See detailUnaudited clinical experience.
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1995), 63(4), 934-5

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See detailL'axe sol-plante-animal dans les tétanies d'herbe
Dufrasne, Isabelle ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139

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See detailThe 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold
Carfi, A.; Pares, S.; Duée, E. et al

in EMBO Journal (1995), 14(20), 4914-4921

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See detailMeasurement of glucosinolates in rapeseeds.
Wathelet, Jean-Paul ULg; Marlier, M.; Severin, M. et al

in Natural toxins (1995), 3(4),

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of ... [more ▼]

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of desulphoglucosinolates is recommended by lSO, the European Committee for Standardizotion (CEN), and the European Commission (EC) as the official method. X-ray fluorescence has also become particularly common for fast analysis. After checking stability of intact glucosinolates in whole rapeseeds, the BCR has three reference materials (CRM 366, CRM 190, CRM 367) avai able, certified for their total glucosinolate and sulphur contents. Currently, the Measurement and Testing Programme is supporting a research project concerning the stdbility of desulphoglucosinolates and intact glucosinolates extracts. At the present time, best results were observed with lyophilized extracts sealed in brown glass ampoules and stored at 18'C. [less ▲]

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See detailKinetic properties of the Bacillus licheniformis Penicillin-binding proteins
Lepage, Sophie; Galleni, Moreno ULg; Lakaye, Bernard ULg et al

in Biochemical Journal (1995), 309

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See detailHypothalamic and Thyroidal Regulation of Growth Hormone in Tilapia
Melamed, P. M.; Eliahu, N. A.; Levavi-Sivan, Berta et al

in General and Comparative Endocrinology (1995), 97

A radioimmunoassay (RIA) for recombinant tilapia growth hormone (GH) was established and validated. The ability of various hypothalamic factors to regulate GH secretion in the tilapia hybrid (Oreochromis ... [more ▼]

A radioimmunoassay (RIA) for recombinant tilapia growth hormone (GH) was established and validated. The ability of various hypothalamic factors to regulate GH secretion in the tilapia hybrid (Oreochromis niloticus x Oreochromis aureus) was studied. Somatostatin1-14 (SRIF1-14; 10-100 micrograms/kg) was found to reduce circulating GH levels in a dose-dependent manner. SRIF1-14 (0.1-1000 nM) inhibited GH release from perifused pituitary fragments (ED50 0.83 nM). Human growth hormone-releasing hormone fragment 1-29 (hGHRH1-29; 100 micrograms/kg) doubled circulating GH levels and modestly stimulated GH secretion in vitro. Carp growth hormone-releasing hormone (cGHRH) stimulated GH secretion in vitro to a similar degree at the same dose (1 microM). Injection of salmon gonadotropin-releasing hormone (sGnRH) superactive analog (10-100 micrograms/kg) increased plasma GH levels sixfold. sGnRH also stimulated GH release in vitro (ED50 142.56 nM). Dopamine (0.1-10 microM) and the D1 DA receptor agonist SKF 38393 increased GH secretion from perifused pituitary fragments dose-relatedly. Thyrotropin-releasing hormone (TRH) had no effect on GH secretion from perifused pituitary fragments, but increased plasma GH levels, as did bovine thyroid stimulating hormone (bTSH). The increased plasma GH in the bTSH-treated fish coincided with a dramatic increase in T4; however, TRH increased GH without changing T4 levels. T3 increased the synthesis of GH by isolated pituitaries (incorporation of [3H]leucine). SRIF1-14 seems to be a most potent hypothalamic regulator of GH secretion in tilapia; sGnRH and DA both increased GH secretion, although sGnRH elicited considerably greater responses at lower doses. Two forms of GHRH increased GH levels, although the unavailability of the homologous peptide prevented an accurate evaluation of its importance in regulating GH secretion. The thyroid axis (TRH, TSH, and T3) stimulates both synthesis and release of GH, although TRH did not appear to have a direct effect on the level of the pituitary. [less ▲]

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See detailCarry-Over Of Morphological And Biochemical Characteristics Associated With Hyperflowering Of Micropropagated Strawberries
Jemmali, A.; Boxus, P.; Kevers, Claire ULg et al

in Journal of Plant Physiology (1995), 147(3-4),

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See detailThe prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency
de Zegher, F.; Pernasetti, F.; Vanhole, C. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(11), 3127-30

The role of thyroid hormone in the human fetus is uncertain; a significant amount of T4 is transferred from the maternal to the fetal circulation. A mother-infant pair was found to be heterozygotic for a ... [more ▼]

The role of thyroid hormone in the human fetus is uncertain; a significant amount of T4 is transferred from the maternal to the fetal circulation. A mother-infant pair was found to be heterozygotic for a point mutation in codon 271 of the gene encoding Pit-1, a pituitary-specific transcription factor regulating somatotrope, lactotrope, and thyrotrope function. At birth, serum T4 was undetectable in mother and infant. The newborn presented with a striking delay of respiratory, cardiovascular, neurological, and bone maturation. Despite replacement therapy since birth, neurological development of the infant is impaired. Fetomaternal Pit-1 deficiency resulted in unmitigated fetal hypothyroidism that unmasked thyroid hormone as a potent endogenous drive of fetal maturation and revealed placental transfer of maternal T4 as a rescue mechanism for infants with congenital hypothyroidism, preventing fetal and neonatal symptoms of thyroid deficiency and safeguarding developmental potential. [less ▲]

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See detailCrystal structure of recombinant triosephosphate isomerase from Bacillus stearothermophilus. An analysis of potential thermostability factors in six isomerases with known three-dimensional structures points to the importance of hydrophobic interactions
Delboni, Luis F; Mande, Shekhar C; Rentier-Delrue, Françoise ULg et al

in Protein Science : A Publication of the Protein Society (1995), 4(12), 2594-604

The structure of the thermostable triosephosphate isomerase (TIM) from Bacillus stearothermophilus complexed with the competitive inhibitor 2-phosphoglycolate was determined by X-ray crystallography to a ... [more ▼]

The structure of the thermostable triosephosphate isomerase (TIM) from Bacillus stearothermophilus complexed with the competitive inhibitor 2-phosphoglycolate was determined by X-ray crystallography to a resolution of 2.8 A. The structure was solved by molecular replacement using XPLOR. Twofold averaging and solvent flattening was applied to improve the quality of the map. Active sites in both the subunits are occupied by the inhibitor and the flexible loop adopts the "closed" conformation in either subunit. The crystallographic R-factor is 17.6% with good geometry. The two subunits have an RMS deviation of 0.29 A for 248 C alpha atoms and have average temperature factors of 18.9 and 15.9 A2, respectively. In both subunits, the active site Lys 10 adopts an unusual phi, psi combination. A comparison between the six known thermophilic and mesophilic TIM structures was conducted in order to understand the higher stability of B. stearothermophilus TIM. Although the ratio Arg/(Arg+Lys) is higher in B. stearothermophilus TIM, the structure comparisons do not directly correlate this higher ratio to the better stability of the B. stearothermophilus enzyme. A higher number of prolines contributes to the higher stability of B. stearothermophilus TIM. Analysis of the known TIM sequences points out that the replacement of a structurally crucial asparagine by a histidine at the interface of monomers, thus avoiding the risk of deamidation and thereby introducing a negative charge at the interface, may be one of the factors for adaptability at higher temperatures in the TIM family. Analysis of buried cavities and the areas lining these cavities also contributes to the greater thermal stability of the B. stearothermophilus enzyme. However, the most outstanding result of the structure comparisons appears to point to the hydrophobic stabilization of dimer formation by burying the largest amount of hydrophobic surface area in B. stearothermophilus TIM compared to all five other known TIM structures. [less ▲]

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See detailVenous Allografts for Critical Limb Ischaemia
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1995), 95(1, Jan-Feb), 14-20

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level ... [more ▼]

In as many as 25% of the patients with critical lower limb ischaemia, a suitable autogenous vein graft is not available. Patency rate of prosthetic grafts is disappointing at the infrageniculate level. Recently, there is renewed interest in the use of preserved venous allografts as an alternate conduit in patients with threatened ischaemic limbs. From 1991 to 1993, the authors revascularized 12 ischaemic limbs with venous allografts (10 preserved at 4 degrees C, 2 Varivas grafts). The indication for operation was rest pain in five patients and tissue necrosis in seven. Nine patients had one or more previous ipsilateral revascularizations. The at 4 degrees C preserved venous allografts were conserved for a near period of 2 months. In only half (5/10) of the cases ABO isocompatibility could be respected. Distal anastomosis was always below the knee. In 6 patients, the anastomosis was at tibial level. There was one rupture of a Varivas graft on the fifth postoperative day, necessitating ligation of the graft and subsequent amputation. All other grafts remained patent for a mean period of 10.6 months. Actually, 6 grafts are still open. Most patients were given aspirin. Only three patients were under oral coumarin anticoagulation in an effort to prevent early graft failure. The limb salvage rate is 67% (8/12) (mean follow-up of 13 months). The authors discuss the clinical experience with venous allografts as published in recent literature. Use of venous allografts for arterial reconstruction in humans was met with limited success so far. The one year patency approximates 50%. Venous allografts progress in an ineluctable way to a fibrous conduit.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailViolence et justice
Steinmetz, Rudy ULg

in Avancées (1995)

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See detailLa gestion en temps réel des opérations relatives à l’exploitation du trafic fluvial
Marchal, Jean ULg; Hage, André ULg; Rodriguez, S.

in Bulletin de l'Association Technique Maritime et Aéronautique (1995)

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See detailApplication des transects pluviométriques spatio-temporels annuels à l’ensemble du territoire sahélien.
Ozer, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailEvidence for a Second Receptor Binding Site on Human Prolactin
Goffin, Vincent; Struman, Ingrid ULg; Mainfroid, V. et al

in Journal of Biological Chemistry (1994), 269(51), 32598-606

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the ... [more ▼]

The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the resulting mutants exhibit reduced bioactivity in the Nb2 cell proliferation bioassay, the mutated residues do not appear to be functionally necessary. Next, small residues surrounding the helix 1-helix 3 interface were replaced with Arg and/or Trp, the aim being to sterically hinder the second binding site. Several of these mutants exhibit only weak agonistic properties, supporting our hypothesis that the channel between helices 1 and 3 is involved in a second receptor binding site. We then analyzed the antagonistic and self-antagonistic properties of native hPRL and of several hPRLs analogs altered at binding site 1 or 2. Even at high concentrations (approximately 10 microM), no self-inhibition was observed with native hPRL; site 2 hPRL mutants self-antagonized while site 1 mutants did not. From these data, we propose a model of hPRL-PRL receptor interaction which slightly differs from that proposed earlier for the homologous human growth hormone (hGH) (Fuh, G., Cunningham, B. C., Fukunaga, R., Nagata, S., and Goeddel, D. V., and Well, J. A. (1992) Science 256, 1677-1680). Like hGH, hPRL would bind sequentially to two receptor molecules, first through site 1, then through site 2, but we would expect the two sites of hPRL to display, unlike the two binding sites of hGH, about the same binding affinity, thus preventing self-antagonism at high concentrations. [less ▲]

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See detailA conserved 5' to 3' exonuclease activity in yeast and human nucleotide excision repair protein RAD2 and XPG
Habraken, Yvette ULg; Sung, Patrick; Prakash, Louise et al

in Journal of Biological Chemistry (1994), 269(50), 31342-5

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See detailTraitement de l'ostéoporose: données actuelles et perspectives
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Franchimont, P.

in Revue du Rhumatisme (1994), 61(10, Pt 2), 155-164

Postmenopausal osteoporosis is characterized not only by a reduction in bone mass but also by bone microarchitecture alterations, which result in greater bone frailty and in an increased fracture risk ... [more ▼]

Postmenopausal osteoporosis is characterized not only by a reduction in bone mass but also by bone microarchitecture alterations, which result in greater bone frailty and in an increased fracture risk. Many drugs have been studied to determine whether they prevent bone loss or reduce the incidence of additional fractures in patients with established osteoporosis. Primary prevention of osteoporosis rests on regular exercising and adequate intake of dietary calcium. For secondary prevention in women undergoing menopause, replacement estrogen therapy given for at least ten years is associated with substantial reductions in fractures of the radius, hip, and spine. Other drugs capable of arresting postmenopausal bone loss include parenteral, nasal or rectal calcitonin and diphosphonates. However, the long-term safety of the latter requires further evaluation. Current studies are evaluating new molecules with potential preventive efficacy, such as ipriflavone. There is no general consensus about the efficacy of treatments for established osteoporosis with fractures. To date, no controlled studies have demonstrated a reduction in the incidence of further fractures in patients given calcium alone. Studies of hydroxylated vitamin D derivatives have been disappointing, although daily administration of vitamin D3 in combination with calcium significantly reduced the incidence of nonvertebral fractures in a population of elderly institutionalized subjects. Plausible explanations for this effect include increased vitamin D levels and reduced parathyroid levels in the bloodstream. Parenteral or nasal calcitonin stabilizes or increases bone mineral content in both cancellous and cortical bone. This effect is especially marked in high-turn-over patients. Several lines of evidence suggest that calcitonin therapy has a protective effect against vertebral and hip fractures. In patients with osteoporosis, oral or intravenous diphosphonates are associated with a significant increase in cancellous bone mass with no loss of cortical bone. Etidronate may be especially beneficial in severe osteoporosis with marked loss of bone and multiple vertebral crush fractures. Fluoride stimulates the growth and synthetic activity of osteoblasts. Accurate information is needed on the optimal dosage of fluoride, on the effects of fluoride on the appendicular skeleton, and, above all, on the biomechanical properties of the bone produced under fluoride therapy. In addition to these commercially available drugs, several other agents are at various stages of the development process.(ABSTRACT TRUNCATED AT 400 WORDS) [less ▲]

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See detailMaladie de Kaposi chez une patiente souffrant d'une immunodéficience acquise VIH négative
Nikkels, Arjen ULg; Collignon, Jacques ULg; Moutschen, M. P. et al

in Presse Médicale (1994), 23(38), 1760-1761

A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and ... [more ▼]

A 79-year-old woman of Mediterranean ascent suffered from corticosteroid-dependent chronic obstructive lung disease, hypogammaglobulinemia (IgG 1 and 2), decreased CD16 natural killer cell function and non-HIV related CD4 and CD8 lymphopenia. Such immunodeficiency could be either a variant of common variable immunodeficiency or an early stage of the idiopathic CD4 + T lymphocytopenia syndrome. She developed bilateral lesions of Kaposi's sarcoma on the lower extremities resembling the classic European type of the disease. The tumors contained both CD34 + and Factor XIIIa + cells. The HLA-DR5 haplotype was not found. Weekly low intravenous dosages of vinblastine improved the lesions but the patient died from pontic infarction. [less ▲]

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See detailA flare event on HR2517
Sterken, C.; Manfroid, Jean ULg

in Information Bulletin on Variable Stars (1994), 4120

Not Available

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See detailA kinetic model of the formation of the hot oxygen geocorona. 1: Quiet geomagnetic conditions
Shematovich, V. I.; Bisikalo, D. V.; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (1994), 99

A model of the hot oxygen geocorona in the transition region near the exobase is described. It is based on a Monte Carlo solution of the nonlinear Boltzmann equation for hot oxygen atoms produced by ... [more ▼]

A model of the hot oxygen geocorona in the transition region near the exobase is described. It is based on a Monte Carlo solution of the nonlinear Boltzmann equation for hot oxygen atoms produced by chemical processes usually considered as a source of hot oxygen (photodissociation of O2 and dissociative recombination of O2(+) and NO(+) ions). The evolution of the system is described stochastically as a series of random Markovian processes. The energy distribution function of the thermal and non-thermal O(3P) atoms and of the nonthermal O(1D) atoms is calculated from the thermospheric collision-dominated region to the exosphere where the gas flow is virtually collisionless. The model is applied to equatorial latitudes for conditions of low solar and geomagnetic activity. Numerical simulations show that the distribution function of thermal oxygen is increasingly perturbed by collisions with the hot oxygen population at high altitudes and departs significantly from a Maxwellian distribution at all altitudues. The number density and temperature of the nonthermal oxygen atoms are derived from their microscopic distribution function and found tobe in qualitative agreement with previous theoretical and experimental estimates. [less ▲]

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See detailLes phéromones humaines: vestige animal ou réalité non reconnue
Foidart, Agnès ULg; Legros, Jean-Jacques ULg; Balthazart, Jacques ULg

in Revue Médicale de Liège (1994), 49(12), 662-80

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See detailEpithelial-to-Mesenchymal Transition in Hpv-33-Transfected Cervical Keratinocytes Is Associated with Increased Invasiveness and Expression of Gelatinase A
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1994), 59(5), 661-6

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on ... [more ▼]

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on collagen rafts. Cell lines from the first group reconstituted CINIII-like lesions, whereas cell lines from the second group reconstituted epithelia comparable to micro-invasive carcinomas. They were thus postulated to represent distinct stages of cervical carcinogenesis. The present results have shown that lines from group I, which have conserved an epithelial morphology in monolayer, (i) could not invade matrigel when tested in a modified Boyden chamber assay, (ii) produced solely gelatinase B and (iii) were unable to activate exogenous gelatinase A. On the other hand, lines from group II associated epithelial-to-mesenchymal transition (acquisition of elongated morphology, vimentin positivity) with high in vitro invasive potential and with the ability both to produce and to activate gelatinase A. These results strongly support the hypothesis that the epithelial-to-mesenchymal transition and the associated events might be implicated in the progression to the metastatic phenotype. [less ▲]

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See detail(Erratum) Further observational evidence that MG J0414+0534 is a gravitational mirage.
Angonin-Willaime, M.-C.; Vanderriest, C.; Hammer, F. et al

in Astronomy and Astrophysics (1994), 292

In Sect. 3.3, the identifications of components A1 and A2 for the optical data were inadvertently inverted. This does not change substantially the discussion; just read A1 for A2 and vice versa. In ... [more ▼]

In Sect. 3.3, the identifications of components A1 and A2 for the optical data were inadvertently inverted. This does not change substantially the discussion; just read A1 for A2 and vice versa. In particular, the ratio A2/A1 = 0.3 cannot be made compatible with the radio value without one or several of the mechanisms we suggested. We apologize for the error and thank Dr S. Mao for bringing it to our attention. Erratum to Astron. Astrophys. 281, 388-394 (1994) [less ▲]

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See detailThe physiological status of the ovarian donor affects the in-vitro development of isolated bovine preantral follicles
FIGUEIREDO, J. R.; HULSHOF, S. C. J.; VANDENHURK, R. et al

in Theriogenology (1994), 42(8), 1303-1310

Described in the present paper is the effect of the physiological status of the ovarian donor on the development of isolated bovine preantral follicles during 5 d of culture. The preantral follicles were ... [more ▼]

Described in the present paper is the effect of the physiological status of the ovarian donor on the development of isolated bovine preantral follicles during 5 d of culture. The preantral follicles were isolated mechanically from ovaries of calves, or nonpregnant, pregnant and postpartum cows collected at the slaughterhouse. There were no differences observed among calves, nonpregnant and pregnant cows, neither in the percentages of morphologically normal follicles, nor in the mean diameter increase during culture. However, preantral follicles isolated from postpartum animals had a lower viability during culture, as demonstrated by significantly lower percentages of morphologically normal and growing follicles as well as by a levier mean diameter increase. Our findings show that the ovarian source may affect development of bovine preantral follicles in vitro, especially when preantral follicles from postpartum cows were used. [less ▲]

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See detailDe ruimtebeleving in Vestdijks Verzamelde verhalen I
Nachtergaele, Lutgarde ULg

in Vestdijkkroniek (1994), 85

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See detailDépression: Intérêt de la variation contingente négative
Papart, Patrick ULg

in Dialogue/Depression (1994)

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See detailA novel glycoprotein of the aspartic proteinase gene family expressed in bovine placental trophectoderm
Xie, Sancai; Low, Boon G.; Nagel, Robert J. et al

in Biology of Reproduction (1994), 51(6), 1145-1153

The pregnancy associated glycoproteins (PAG 1) that appear in the maternal serum of cattle and sheep soon after implantation are apparently inactive members of the aspartic proteinase family. Here we ... [more ▼]

The pregnancy associated glycoproteins (PAG 1) that appear in the maternal serum of cattle and sheep soon after implantation are apparently inactive members of the aspartic proteinase family. Here we describe the isolation of a highly abundant cDNA (PAG 2 cDNA) that represents a second member of this gene family which is structurally related to bovine PAG 1, ovine PAG 1, and pepsin (58%, 58%, and 51% amino acid sequence identity, respectively). The bovine PAG 2 cDNA was identified in two ways. First, the bovine placental library was screened under relatively nonstringent conditions with an ovine PAG 1 cDNA. The second fortuitous approach employed immunoscreening with an antiserum raised against a partially purified factor that competed with bovine LH for binding to the LH receptor on the CL of the ovary. The full-length cDNA (1258 bp) codes for a polypeptide of 376 amino acids. Bovine PAG 2, unlike bovine PAG 1, has a catalytic center with a consensus sequence of amino acids. Its mRNA is expressed in fetal placenta but not in other fetal organs, and is localized to both the mononucleate and binucleate cells of the trophectoderm, whereas PAG 1 is expressed only in binucleate cells. PAG 2 is synthesized by placental explants as a 70-kDa glycoprotein that is processed to several smaller molecules. Western blot analysis of culture media developed with epitope-selected antibodies to PAG 2 reveals several bands ranging in apparent M(r) from 31,000-70,000, which correspond in size to the polypeptides present in the preparation used for immunization [less ▲]

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See detailVaricelle et zona: Virus VZV, étiologie, complications et traitement
Rentier, Bernard ULg; Piette, Jacques ULg; Nikkels, Arjen ULg

in Patient Care (1994), 17

La varicelle est une affection très fréquente et très contagieuse. Presque toujours bénigne chez l'enfant, elle peut être plus grave chez l'adulte. Quant au zona, il frappe essentiellement les adultes. C ... [more ▼]

La varicelle est une affection très fréquente et très contagieuse. Presque toujours bénigne chez l'enfant, elle peut être plus grave chez l'adulte. Quant au zona, il frappe essentiellement les adultes. C'est le seul et même virus de la varicelle et du zona (Varicella-Zoster Virus, VZV) qui constitue le lien commun entre les 2 maladies. Sa particularité est de fonctionner par disparition-réactivation. Le VZV appartient à la famille des Herpesviridae. Proche des autres Herpès-virus comme les virus de l'Herpes simplex (HSV-1 et HSV-2), le cytomégalovirus (CMV), le virus d'Epstein-Barr (EBV) et les Herpèsvirus humains 6 et 7 (HHV-6 et HHV-7) nouvellement décrits, il possède néanmoins certaines caractéristiques propres. [less ▲]

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See detailSimulated growth front of 123-(RE)BCO near 211 particles
Vandewalle, Nicolas ULg; Cloots, Rudi ULg; Ausloos, Marcel ULg

in Physica C: Superconductivity (1994), 235(Part 1), 427-428

The microstructural features observed on some DyBa2Cu3O7-x, samples show that kinetic considerations are as important as thermodynamic ones. In order to compute and characterize the kinetic growth front ... [more ▼]

The microstructural features observed on some DyBa2Cu3O7-x, samples show that kinetic considerations are as important as thermodynamic ones. In order to compute and characterize the kinetic growth front of 123-(RE)BCO compounds, we have introduced an anisotropic growth direction into a simple two-dimensional growth model: the Eden model defined on a square lattice. The presence of 211 particles has been also considered. The simulated patterns in the ab and ac planes agree with observations and contribute to a more comprehensive model of the kinetic of the growth front near 211 particles. [less ▲]

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See detailReduction of Temporalis Exteroceptive Suppression by Peripheral Electrical Stimulation in Migraine and Tension-Type Headaches
Wang, W.; Schoenen, Jean ULg

in Pain (1994), 59(3), 327-34

Inhibition of the second exteroceptive suppression of temporalis muscle activity (ES2) produced by a preceding electrical stimulus applied at the index was studied in patients suffering from migraine ... [more ▼]

Inhibition of the second exteroceptive suppression of temporalis muscle activity (ES2) produced by a preceding electrical stimulus applied at the index was studied in patients suffering from migraine without aura (MO), chronic (CTH) or episodic (ETH) tension-type headache. Each patient group comprised of 12 subjects was compared to a group of healthy controls. Mean duration of unconditioned ES2, measured on 10 averaged rectified responses after labial stimulation at a 0.1 Hz frequency, was reduced in CTH only. From stimulation intensities of 20 mA onward, peripheral-induced inhibition of temporalis ES2 was significantly more pronounced in both subtypes of tension-type headache compared to migraineurs or controls. After an index finger stimulus of 20 mA, temporalis ES2 was abolished in 83% of CTH, 67% of ETH, 25% of MO patients and 8% of controls, whereas unconditioned ES2 was present in all patients. Among 9 ETH patients with normal (> or = 32 msec) unconditioned ES2, 5 had total disappearance of ES2 after a 20 mA index stimulation. These results demonstrate that peripheral conditioning at 20 mA increases the diagnostic sensitivity of ES2 studies. They suggest that the changes observed in tension-type headache are due to hyperexcitability of the reticular nuclei which inhibit the medullary inhibitory interneurons mediating ES2. [less ▲]

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See detailViral glycoproteins in herpesviridae granulomas
Nikkels, Arjen ULg; Debrus, S.; Delvenne, Philippe ULg et al

in American Journal of Dermatopathology (1994), 16(6), 588-592

Granulomatous reactions after varicella zoster virus (VZV) and herpes simplex virus (HSV) infections are rare, and their pathogenesis remains unclear. We studied by immunohistochemistry and in situ ... [more ▼]

Granulomatous reactions after varicella zoster virus (VZV) and herpes simplex virus (HSV) infections are rare, and their pathogenesis remains unclear. We studied by immunohistochemistry and in situ hybridization early granulomatous reactions after VZV and HSV infections. In the five cases studied, the VZV glycoproteins gp I and gp II were present in cells abutted to altered vessels, but the corresponding genome sequences were disclosed in similar locations in only one of these cases. In an immunocompromised patient with diffuse HSV eruption, HSV I antigens were present in cells of the reticular dermis, while viral nucleic acids were not evident. Immunophenotyping of the granulomas showed strong Mac 387 and CD68 positive labelings of macrophages/monocytes, without any involvement of Factor XIIIa-positive cells. These findings suggest that the major viral envelope glycoproteins, rather than complete viral particles could trigger granuloma formation following HSV and VZV skin infections. [less ▲]

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See detailDyBa2Cu307-Y superconducting materials synthesized in-situ in a magnetic-field - relations between structure and properties
Cloots, Rudi ULg; Diko, P.; Godelaine, P. A. et al

in Physica C: Superconductivity (1994), 235(Part 1), 357-358

We have synthesized c-axis oriented magnetically melt textured grown DyBa2Cu3O7-y samples at 1035 degrees C under 0.6 T magnetic induction. We discuss the crystal growth mechanism of such 123 melt ... [more ▼]

We have synthesized c-axis oriented magnetically melt textured grown DyBa2Cu3O7-y samples at 1035 degrees C under 0.6 T magnetic induction. We discuss the crystal growth mechanism of such 123 melt textured grown superconducting ceramics. A strictly tridimensional model is proposed based on Schmitz et al. model, taking into account the peculiar physical properties reported for such materials. In particular a filamentary one dimensional electron conduction path at the percolation threshold is emphasized. We have used optically polarized ligth microscopy as well as electron microscopy analysis to deduce the growth steps. [less ▲]

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See detailEvaluation de la durée de vie des outils de fraisage
Debongnie, Jean-François ULg

in European Journal of Mechanical and Environmental Engineering (1994), 39(3), 151-155

A method of prediction of the life of milling tools is presented. Founded on the cumulative damage principle, this method evenly covers peripherical and face milling. In the latter case, the theory is ... [more ▼]

A method of prediction of the life of milling tools is presented. Founded on the cumulative damage principle, this method evenly covers peripherical and face milling. In the latter case, the theory is illustrated by a comparison of symmetrical and asymmetrical face milling from the point of view of tool life. [less ▲]

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See detailTyping of Clostridium Perfringens by in Vitro Amplification of Toxin Genes
Daube, Georges ULg; China, Bernard; Mainil, Jacques ULg et al

in Journal of Applied Bacteriology (1994), 77(6), 650-655

The strains of Clostridium perfringens are classified according to major toxins produced. Classically, this determination involves the seroneutralization of their lethal effect in mice. However, this ... [more ▼]

The strains of Clostridium perfringens are classified according to major toxins produced. Classically, this determination involves the seroneutralization of their lethal effect in mice. However, this method requires specific antisera and a large number of mice. In this work, a new typing method was developed based on the amplification of toxin genes by polymerase chain reaction (PCR). By combination of several pairs of primers, the toxinotype of a Cl. perfringens strain was determined by looking at the pattern of bands on an agarose gel electrophoresis. This mixture contained primers amplifying simultaneously a part of alpha-toxin, beta-toxin, epsilon-toxin and enterotoxin genes. In order to distinguish between toxinotype A and E, the l-toxin gene fragment must be amplified in a separate PCR reaction. Moreover, with the primers combination, in most cases, a PCR product corresponding to the alpha-toxin gene was obtained from direct enrichments of animal intestinal contents. [less ▲]

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See detailExpression of gelatinases A and B and their tissue inhibitors by cells of early and term human placenta and gestational endometrium
Polette, Myriam; Nawrocki, B.; PINTIAUX, Axelle ULg et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1994), 71(6), 838-846

BACKGROUND: Human placentation is mediated by fetal trophoblastic cells that invade the maternal uterine endometrium. Trophoblast invasion requires a precisely regulated secretion of specific proteolytic ... [more ▼]

BACKGROUND: Human placentation is mediated by fetal trophoblastic cells that invade the maternal uterine endometrium. Trophoblast invasion requires a precisely regulated secretion of specific proteolytic enzymes able to degrade the endometrial basement membrane and extracellular matrix. EXPERIMENTAL DESIGN: Several studies have documented the key roles of matrix metalloproteinases and their tissue inhibitors in the invasion of various matrices by cultured trophoblasts. In vitro studies suggest that placentation could result from a balance between the secretion of these enzymes by trophoblast cells and their inhibition by the natural tissue inhibitors (TIMPs) produced by maternal decidual cells. The precise localization and levels of expression of these proteins that account for and control invasion during human placentation in vivo however, have not been described. We have evaluated, in vivo, by immunohistochemistry, Northern blot analysis and in situ hybridization, the expression of two metalloproteinases (gelatinases A and B) and their two tissue inhibitors (TIMPs 1 and 2) in placental villi and placental beds of first and third trimesters of normal pregnancy. RESULTS: Human first trimester intermediate trophoblast produced both gelatinases A and B; these two gelatinases were respectively less and no more detected at term in these cells. We found that both TIMP1 and 2 were also expressed in maternal decidual cells with a dramatic increase of TIMP1 at the term of pregnancy. In floating villi, gelatinase A and TIMP1 were localized in the stromal compartment, whereas gelatinase B and TIMP2 were codistributed in trophoblast cells. CONCLUSIONS: The gelatinases A and B and their tissue inhibitors are thus expressed by specific cells in early and late placental beds and villi. This pattern of expression varies during pregnancy. Therefore, our morphologic study supports biologic findings suggesting that these proteins may participate in placentation. [less ▲]

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See detailCryptocrine Signaling in the Thymus Network. Implications for Central T-Cell Tolerance of Neuroendocrine Functions
Geenen, Vincent ULg; Cormann-Goffin, Nadine; Vandersmissen, Eric et al

in Annals of the New York Academy of Sciences (1994), 741

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See detailHeavy fermion behavior of U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

in Journal of Applied Physics (1994), 76(10), 6214-6215

Magnetic and specific-heat studies of U2T2X compounds show a frequent occurrence of the gamma enhancement in conjunction with the onset of antiferromagnetic ordering. The largest value of 830 mJ/mol K**2 ... [more ▼]

Magnetic and specific-heat studies of U2T2X compounds show a frequent occurrence of the gamma enhancement in conjunction with the onset of antiferromagnetic ordering. The largest value of 830 mJ/mol K**2 was observed in U2Pt2In, which is nonmagnetic down to 1.2 K. Variations of electronic structure are documented by optimized relativistic LCAO calculation. [less ▲]

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See detailLe traitement bronchodilatateur du patient BPCO (1994)
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Louis, Renaud ULg et al

in Revue Médicale de Liège (1994), 49(11), 593-5

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See detailAstroglia-Released Factor Shows Similar Effects as Benzodiazepine Inverse Agonists
Rigo, Jean-Michel; Belachew, Shibeshih ULg; Lefebvre, P. P. et al

in Journal of Neuroscience Research (1994), 39(4), 364-76

Media conditioned by cultured neonatal cerebral cortex microexplants (CCM) or astrocytes (ACM) contain low molecular weight (< 1,000 Da) substance(s) which inhibits the gamma aminobutyric acid (GABA ... [more ▼]

Media conditioned by cultured neonatal cerebral cortex microexplants (CCM) or astrocytes (ACM) contain low molecular weight (< 1,000 Da) substance(s) which inhibits the gamma aminobutyric acid (GABA)-induced inward current recorded in cerebellar granule cells and hippocampal neurons in culture using the whole-cell patch-clamp technique. This effect is specific for CCM and ACM, as medium conditioned by PC12 cells (PC12CM) does not affect the GABA response of these cells. It is also specific for GABA-induced currents because glutamate-induced currents do not change either in amplitude or in shape in the presence of CCM or ACM. The inhibitory effect on the GABA response in cerebellar granule cells of both ACM and CCM could be suppressed by flumazenil, a specific benzodiazepine (BZD) antagonist and could be mimicked by two BZD inverse agonists. These data thus demonstrate the presence of a BZD inverse agonist-like activity in CCM and ACM. This effect of ACM on different neuronal cell types was heterogenous since no detectable effect could be observed on the GABA-induced current in GABA-responsive dorsal root ganglion (DRG) neurons, presumably reflecting a functional heterogeneity of the GABAA receptors present in these different neuronal subsets. By the release of such an endogenous BZD inverse agonist-like activity, glia cells could possibly modulate GABAA receptor-mediated responses. [less ▲]

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See detailThe morphology of the north Jovian ultraviolet aurora observed with the Hubble Space Telescope
Gérard, Jean-Claude ULg; Dols, Vincent; Prange, Renee et al

in Planetary and Space Science (1994), 42

A series of six images covering a complete rotation of the north polar region of Jupiter were obtained in February 1993 with the Faint Object Camera on board the Hubble Space Telescope (HST). These images ... [more ▼]

A series of six images covering a complete rotation of the north polar region of Jupiter were obtained in February 1993 with the Faint Object Camera on board the Hubble Space Telescope (HST). These images provide the first global picture of the morphology of the Jovian ultraviolet aurora observed from Earth orbit. The camera passband was centered near 153 nm, a region dominated by the H2 Lyman bands and continuum. The successive exposures, taken approximately 90 min apart, are used to construct a polar view of the auroral zone. It is found that the auroral emissions do not exactly follow the footprint of a constant L-shell although the size of the oval and its location agree best with the footprints of the approximately equal to 30 R[SUB]J[/SUB] field line in the GSFC O6 model of the Jovian magnetic field. The displacement between the observed auroral zone and the theoretical oval may indicate a possible distortion of the Jovian magnetic field lines near the surface. A comparison with two images at the same wavelength obtained 8 months earlier shows that the main morphological features are persistent, in spite of changes in the detailed emission distribution. Small scale features with characteristic sizes of approximately 1000 km are observed along the auroral oval. The change of morphology observed as a function of the System 3 longitude appears as a persistent characteristic of the morphology of the north polar aurora. [less ▲]

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See detailAre Similar Inflammatory Factors Involved in Strenuous Exercise and Sepsis?
Camus, G.; Deby, Ginette ULg; Duchateau, J. et al

in Intensive Care Medicine (1994), 20(8), 602-10

An increasing body of data suggest that strenuous exercise triggers an inflammatory response having some similarity with those occurring in sepsis. Indices of this inflammatory response to exercise (IRE ... [more ▼]

An increasing body of data suggest that strenuous exercise triggers an inflammatory response having some similarity with those occurring in sepsis. Indices of this inflammatory response to exercise (IRE) especially include leukocytosis, release of inflammatory mediators and acute phase reactants, tissue damage, priming of various white blood cell lines, production of free radicals; activation of complement, coagulation and fibrinolytic cascades. Inflammatory responses to strenuous exercise and sepsis could in part be due to the release of endotoxin in blood as common triggering factor, but it seems that tissue damage and/or contact system activation are more important triggering mechanisms in exercising subjects. While the magnitude and duration of cellular and humoral changes associated with IRE are quite different from those observed in sepsis, recent human studies suggested that chronic and/or excessive IRE could have adverse effects. Among the possible consequences of acute and chronic IRE are delayed onset muscular soreness and loss of force, cardiovascular complications, intravascular hemolysis, hypoferraemia and increased susceptibility to infection. [less ▲]

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See detailL'épilepsie essentielle au Rorschach et au Szondi
Stassart, Martine ULg

in Cahiers du CEP (Centre d'Etudes Pathoanalytiques) (1994), 4

Twenty essential epileptics were examined with help of the Rorschach and Szonditests.The results show that the classical signs of "épileptoïdie" are present by all the subjects. There is thus a specifical ... [more ▼]

Twenty essential epileptics were examined with help of the Rorschach and Szonditests.The results show that the classical signs of "épileptoïdie" are present by all the subjects. There is thus a specifical pattern of personnality by this seizure of epilepsy. [less ▲]

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See detailPretreatment minimal staging for non-small cell lung cancer: an updated consensus report
Barthelemy, Nicole ULg; Goldstraw; Rocmans et al

in Lung Cancer (1994), 11(3),

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See detailL'épilepsie de Vincent VAN GOGH
Blumer, Dietrich; Stassart, Martine ULg

in Cahiers du CEP (Centre d'Etudes Pathoanalytiques) (1994), 4(4), 3-10

Though he never had typical "grand mal" crisis, Vincent VAN GOGH was really epileptic. The symptomatology of epileptic seizures was better known in the XIXd Century than today.

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See detailVariable regions of chromosome 11 loss in different pathological tissues of a patient with the multiple endocrine neoplasia type I syndrome.
Beckers, Albert ULg; Abs, R.; Reyniers, E. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(5), 1498-1502

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited disorder characterized by nodular proliferation of the parathyroid glands and tumors of the anterior pituitary gland, the ... [more ▼]

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant inherited disorder characterized by nodular proliferation of the parathyroid glands and tumors of the anterior pituitary gland, the endocrine pancreas, and the neuroendocrine cell system of the gut. Loss of the putative tumor suppressor effect of the MEN1 gene is probably responsible for the development of MEN1-associated tumors. We report here a genetic study of a female MEN1 patient with the association of nodular hyperplasia of two parathyroid glands, an insulinoma, multiple duodenal gastrinomas, a prolactinoma, and a gastric carcinoid. We performed loss of heterozygosity (LOH) studies of chromosome 11 on all affected tissues except the insulinoma. Allelic losses of chromosome 11 were detected in several tumors, but the chromosomal regions of LOH were different, suggesting that different somatic mutational events are involved in the pathogenesis of these tumors. LOH of chromosome 11 was also detected in the prolactinoma of this patient, which indicates that the MEN1 gene has a tumor suppressor effect in the pituitary. [less ▲]

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