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See detailAssessment of the cell-mediated immunity in cattle infection after bovine herpesvirus 4 infection, using an in vitro antigen-specific interferon-gamma assay.
Godfroid, J.; Czaplicki, G.; Kerkhofs, P. et al

in Veterinary Microbiology (1996), 53(1-2), 133-41

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has ... [more ▼]

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has been reported to be positive in only few animals showing serological evidences of BHV4 infection. We have investigated the CMI following BHV4 infection by an in vitro antigen-specific interferon gamma (IFN-gamma) release assay, as an indicator of an actively acquired immunity to BHV4. Our preliminary results using a partially purified antigen suggest that there was a measurable CMI in 75 out of 168 animals (44.4%) originating from a farm with a clinical history and serological evidences (76.3% seropositivity) of BHV4 infection. If the results of serological tests and BHV4 IFN-gamma test are interpreted in parallel, 81.5% of the animals are classified positive, demonstrating the complementarity of these tests. The specificity of the BHV4 IFN-gamma test was supported by the absence of a measurable CMI in 41 animals originating from a farm with no clinical history or serological evidence of BHV4 infection. In an allied study, we developed a bovine herpesvirus 1 (BHV1) IFN-gamma test. This allowed us to measure the antigen specific IFN-gamma release after stimulation with a mixture of BHV1 and BHV4 antigens. Animals that were classified negative by the BHV4 IFN-gamma test and by the BHV1 IFN-gamma test, were classified negative after stimulation with a mixture of both antigens. Animals that were classified positive by the BHV4 IFN-gamma test or the BHV1 IFN-gamma test, were classified positive after stimulation with a mixture of both antigens. Taken together these results suggest that the in vitro assessment of the CMI after BHV4 infection should be further investigated as a specific and valuable alternative to the DTH assay. [less ▲]

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See detailExpression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat.
Plumier, Jean-Christophe ULg; Armstrong, J. N.; Landry, J. et al

in Neuroscience (1996), 75(3), 849-56

Western analysis and immunohistochemistry were used to determine the time-course and the distribution of the 27,000 mol. wt heat shock protein, Hsp27, in rat brain following systemic administration of ... [more ▼]

Western analysis and immunohistochemistry were used to determine the time-course and the distribution of the 27,000 mol. wt heat shock protein, Hsp27, in rat brain following systemic administration of kainic acid. No Hsp27 immunoreactivity was detected in naive control animals or in rats that failed to develop status epilepticus. Hsp27 immunoreactivity was detected as early as 12 h in the parietal cortex, piriform cortex and the hippocampus of rats that developed status epilepticus. The number of cells expressing Hsp27 and the intensity of Hsp27 immunoreactivity were increased 24 h after kainic acid administration. Hsp27 immunoreactivity was still observed seven days post-kainic acid injection. The morphology of the Hsp27-positive cells and double immunofluorescence against Hsp27 and glial fibrillary acidic protein revealed that Hsp27-positive cells were astrocytes. In addition, the distribution of Hsp27 suggested that astrocytic Hsp27 was dependent on excitation-induced metabolic stress rather than the direct effect of kainic acid on astrocytes. [less ▲]

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See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

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See detailAbsolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1996), C52

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See detailRuminal, cardiorespiratory and adrenocortical sequelae of Na2EDTA-induced hypocalcemia in calves
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Veterinary Research Communications (1996), 20

A study was undertaken to provide further information on the ruminal, cardiorespiratory and hypothalamo-pituitary-adrenocortical (HPAC) physiological sequelae of hypocalcaemia in dairy calves. The ... [more ▼]

A study was undertaken to provide further information on the ruminal, cardiorespiratory and hypothalamo-pituitary-adrenocortical (HPAC) physiological sequelae of hypocalcaemia in dairy calves. The functional picture observed in standing calves experiencing Na2EDTA-induced progressive hypocalcaemia showed a biphasic pattern. During the first phase (Ca2+ varying between 1.20 +/- 0.09 and 0.64 +/- 0.15 mmol/L, mean +/- SD), the animals became dull and lethargic, shifting their weight from one hind limb to the other, with cool extremities and hypersalivation. Their ventilation was slightly increased but their heart rate, thoracoabdominal pressure, pulmonary mechanics, haemoglobin and temperature remained constant. Conversely, their systemic arterial pressure (SAP) and the amplitude of their ruminal contractions (RCA) were severely decreased. During the second phase (Ca2+ < 0.64 +/- 0.15 mmol/L), there was restlessness, tachycardia, hypertension, polycythaemia and, finally, inability to stay upright. It is suggested that the diminished Ca2+ availability caused smooth-muscle and myocardial dysfunctions which could explain the RCA and SAP changes recorded during the first phase, whereas neural and/or humoral sympathetic discharge probably accounted for the reversal in SAP and heart rate when Ca2+ was decreased further. Serum cortisol increased regularly and remained significantly correlated with Ca2+ in each animal. Moreover, regression of delta cortisol/delta Ca2+ on delta Ca2+/delta Na2EDTA was significant (p < or = 0.001). It was concluded that mild asymptomatic hypocalcaemia severely impairs ruminal function, which will progressively worsen the Ca2+ deficit; that the inability to maintain posture in hypocalcaemia is not due to hypotension; and that the higher the HPAC response to hypocalcaemia, the higher the resistance to its effects. An asymptomatic periparturient cow with barely detectable ruminal activity may merit preventive calcium borogluconate therapy. Also, the physiological role of hypotension in explaining the clinical picture may be less important than other processes, such as neuromuscular failure. Finally, the present results imply a possible HPAC exhaustion in cows with periparturient paretic hypocalcaemia [less ▲]

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See detailStructure and bonding in liquid tellurium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Physical Review. B, Condensed Matter and Materials Physics (1996), 53(1), 206-211211

The atomic structure and bonding mechanism in liquid tellurium have been investigated by a tight-binding Monte Carlo simulation. On melting, the chain structure of the crystal is preserved in spite of ... [more ▼]

The atomic structure and bonding mechanism in liquid tellurium have been investigated by a tight-binding Monte Carlo simulation. On melting, the chain structure of the crystal is preserved in spite of some significant changes in the local atomic environment. A third covalent bond appears with a bond length (widely distributed around 3.15 Aring) intermediate between those characteristic of the crystal. A short-long alternation of the bonds takes place within the chains, in agreement with the most recent extended X-ray-absorption fine structure measurements. In addition, the bond angle within the chains is reduced. Our calculations clearly prove that these effects are due to the electronic interaction between the lone pair orbitals. The subsequent broadening of the lone pair band is responsible for the semiconductor to metal transition that takes place upon melting. [less ▲]

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See detailFirst synthesis of 4-substituted benzenesulfonylcyanoguanidines
Masereel, B.; Lebrun, P.; Dogne, J.-M. et al

in Tetrahedron Letters (1996), 37

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See detailRemarques sur le bilinguisme gréco-latin
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (1996), 64

Réflexions sur la coexistence de l'emploi des langues grecque et latine dans le monde méditerranéen antique, ce phénomène étant considéré principalement sous son aspect littéraire, dans une perspective ... [more ▼]

Réflexions sur la coexistence de l'emploi des langues grecque et latine dans le monde méditerranéen antique, ce phénomène étant considéré principalement sous son aspect littéraire, dans une perspective diachronique. Les pionniers de la littérature latine furent des affranchis de langue grecque qui s'exprimaient en latin. Dès la fin du deuxième siècle av. J.-C., même si l'apport des affranchis grecs à l'histoire romaine reste important, de nombreux Romains cultivés s'expriment en grec. Devant les ressources qu'offre la langue grecque, plus d'un auteur latin, jusqu'à la fin de la République, déplore la « patrii sermonis egestas ». Mais Cicéron affirme la richesse du lexique latin et entreprend avec un grand souci d'exactitude des traductions du grec en latin. Finalement, durant toute la période impériale, les deux langues se complètent et s'équilibrent. [less ▲]

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See detailRecent advances in prostate cancer metastasis
Waltregny, David ULg; Castronovo, Vincenzo ULg

in Tumori (1996), 82(3, May-Jun), 193-204

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy ... [more ▼]

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy that exists between the prevalence of 'latent' cancer, recognizable only histologically, and that of the clinical disease. Histologically detected localized prostate cancers are heterogeneous, with only a small subset having undergone all of the malignant changes required to produce clinically aggressive tumors. Most of these 'latent' carcinoma never become fully malignant and do not threaten the life or well-being of the host. At present, it is not possible to predict which localized cancers will progress to clinically overt disease. Likewise, many patients have underevaluated and unpredictable extent of their prostate carcinoma, thus resulting in inadequate therapeutic strategies. It is clear that we need to identify molecular and/or cellular markers that are able to define the invasive and metastatic potential of prostate cancer on an individual patient basis. Acquisition of metastatic ability is a definitive criterion by which substage localized prostate cancers. Under the light of recent studies designed to identify some of the features associated with the metastatic phenotype of prostate cancer, the authors review recent advances aimed at gaining insight into those factors that may be involved in prostate cancer metastasis. [less ▲]

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See detailEffects of castration on fear reactions of male sheep.
Vandenheede, Marc ULg; Bouissou, Marie-France

in Applied Animal Behaviour Science (1996), 47

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See detailActivation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Journal of Pharmacology and Experimental Therapeutics (The) (1996), 277

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See detailGranuloma tuberculoide post-herpético en un paciente con leucemia linfocítica crónica
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in Medicina Cutanea Ibero-Latino-Americana (1996), 24

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See detailLes champs électromagnétiques de faible intensité produisent une vague calcique dans les fibroblastes
Bomans, J.; Lambert, C. A.; Scarpa, B. et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(3-4), 243-9250-2

Human fibroblasts display a Ca2+ wave after irradiation with an electromagnetic field (EMF) of low intensity (100 to 900 microT) as seen by LASER confocal microscopy and excitation of Fluo 3. The number ... [more ▼]

Human fibroblasts display a Ca2+ wave after irradiation with an electromagnetic field (EMF) of low intensity (100 to 900 microT) as seen by LASER confocal microscopy and excitation of Fluo 3. The number of excited cells is proportional to the intensity of EMF between 100 and 900 microT. Cellular activation by a dialysable serum factor is required to induce the Ca2+ wave. It also depends on extracellular Ca2+ and active tyrosine kinases and phospholipase C gamma. [less ▲]

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See detailImprovement in the inflammatory aspect of androgenetic alopecia. A pilot study with an antimicrobial lotion
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Tassoudji, Nazli ULg et al

in Journal of Dermatological Treatment (1996), 7

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This ... [more ▼]

Androgenetic alopecia (AGA) is a common yet poorly understood condition. In particular, the significance of inflammatory cells close to the infrainfundibulum of transitional hairs remains obscure. This study was conducted in 20 men who used a lotion containing the antimicrobials, piroctone olamine and triclosan, regularly for 18 months. At entry, mild pruritus and abnormal hair loss were reported by the volunteers. During treatments, pruritus resolved rapidly. Comparison of clinical photographs and trichograms taken at 3-month intervals suggested signs of hair regrowth with moderate increase in density of transitional hairs. Biopsies taken at 6-month intervals were processed for immunohistochemistry. There was a decrease in the density of activated T cells in the region of the follicular infrainfundibulum and isthmus over time. UgG deposits found within the epithelial sheaths at entry to the study were absent in the subsequent biopsies. The volume of the sebaceous glands, as assessed by computerized morphometry, was not modified by the treatment. It was concluded that inflammation associated with AGA transitional hairs may be driven by the presence of microorganisms harboured in the infrainfundibulum. They may modulate the severity of AGA and may potentially be controllable. This offers a new possibility of prevention and partial reversal of hair loss in AGA. [less ▲]

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See detailImages liées à la pathologie traumatique du système nerveux central
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 216

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See detailShedding of the 67-kD laminin receptor by human cancer cells.
Karpatova, M.; Tagliabue, E.; Castronovo, Vincenzo ULg et al

in Journal of Cellular Biochemistry (1996), 60(2), 226-34

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix ... [more ▼]

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix has been recently suggested by electron microscopy studies, there is to date no evidence of shedding of the 67LR from cells. Using two monoclonal antibodies directed against the 67LR, we developed a double-determinant radioimmunoassay that demonstrates that the 67LR is released from cancer cells into the culture medium. The shed molecule exhibited the same apparent molecular weight as that of the membrane-associated 67LR, suggesting that no proteolytic cleavage is involved in the process. Furthermore, we demonstrate that the 67LR is not anchored to the membrane through a glycolsyl-phosphatidylinositol bridge. However, the observation that lactose increased the release of 67LR suggests that a lectin-type interaction is involved in the cell membrane association of this laminin binding protein and the cell surface. Interestingly, the released 67LR recovered after HPLC gel filtration was found free as well as associated to high molecular weight complexes. The free 67LR retained its ability to bind to the cell surface. Our study is the first demonstration that the 67LR is effectively shed by cancer cells. The released free 67LR could play an important role in modulating interactions between cancer cells and laminin during tumor invasion and metastasis. [less ▲]

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See detailMT-MMP Expression and localisation in human lung and breast cancers
Polette, M.; Nawrocki-Raby, B.; Gilles, Christine ULg et al

in Virchows Archiv : An International Journal of Pathology (1996), 428(1), 29-35

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ ... [more ▼]

Thirteen primary pulmonary squamous cell carcinomas, 4 specimens of normal lung from around tumours, 4 benign proliferations of the mammary gland and 16 breast carcinomas were analysed by in situ hybridisation. Northern blot and immunohistochemistry for the expression of a recently described metalloproteinase (MMP), the MT-MMP (membrane-type matrix metalloproteinase). This MT-MMP can activate gelatinase A, involved in the degradation of basement membranes. In situ hybridisation revealed MT-MMP transcripts distributed in both tumour and stromal cells in squamous cell lung cancers, whereas these mRNAs were principally detected in stromal cells in close contact to tumour clusters in breast carcinomas and in lung adenocarcinomas. Northern blot analysis showed a parallel expression of MT-MMP and gelatinase A transcripts in both lung and breast cancers. Immunohistochemistry displayed a more extensive distribution of MT-MMP in pulmonary and mammary carcinomas with numerous labelled preinvasive and infiltrating cancer cells and stromal cells near the tumour cells. The large degree of expression of MT-MMP in these cancers indicates a potential role of this enzyme in tumour progression. The finding of MT-MMP transcripts in stromal cells in the vicinity of lung and breast tumour cells emphasises the cooperation between these cells and cancer cells for the expression of MT-MMP and in tumour invasion in vivo. [less ▲]

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See detailMort mitotique ou mort apoptotique par irradiation : Même combat ?
Coucke, Philippe ULg; ZOUHAIR

in Médecine et Hygiène (1996), 54(2121), 1241-1245

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement ... [more ▼]

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement oncologique. Les radiations ionisantes sont capables d'induire une mort mitotique et une mort apoptotique. Nous définissons les caractéristiques radiobiologiques de chaque type de mort cellulaire et situons l'importance de l'apoptose pour la réponse tumorale aux radiations ionisantes. La modulation de ce «suicide cellulaire» devrait permettre une amélioration de l'index thérapeutique mais ceci implique une connaissance approfondie des mécanismes qui règlent l'apoptose [less ▲]

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See detailNutritional and animal husbandry aspects of rearing early life stage of Eurasian perch Perca fluviatilis
Kestemont, Patrick; Mélard, Charles ULg; Fiogbe, Emile et al

in Journal of Applied Ichthyology (1996), 12

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See detailRelationship between Parathion and Paraoxon Toxicokinetics, Lung Metabolic Activity, and Cholinesterase Inhibition in Guinea Pig and Rabbit Lungs
Lessire, Françoise ULg; Gustin, Pascal ULg; Delaunois, Annie et al

in Toxicology and Applied Pharmacology (1996), 138(2), 201-210

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A ... [more ▼]

Kinetic parameters of parathion and paraoxon uptake were determined in isolated and perfused rabbit and guinea pig lungs. They were related to organophosphate-induced lung cholinesterase inhibition. A single pass procedure was used to perfuse the lungs with an artificial medium perfusate containing paraoxon or parathion. The paraoxon and parathion concentrations were determined in the effluents collected at chosen intervals over an 18-min period beginning at the start of perfusion. Three inflowing concentrations (1 nmol/ml, 10 nmol/ml, and 20 nmol/ml) were tested in guinea pig lungs and one (10 nmol/ml) in rabbit lungs. Cholinesterase activity was determined at time 0 and at the end of the experiment. The lungs abundantly extracted paraoxon and parathion over the perfusion period. The extraction ratio was consistently greater in guinea pig than in rabbit lungs. The uptake velocity varied biexponentially in time, suggesting the existence of two compartments. Initial uptake velocities (A, B) and slopes (alpha and beta) were calculated for both compartments. In guinea pigs, A, B and A + B increased proportionally to the supply rate of paraoxon and parathion while a and b remained constant. No significant difference was observed between parathion and paraoxon uptake kinetics. Parameter B was the only one to differ significantly between the two species (rabbits: 8.19 +/- 1.53 for parathion and 6.85 +/- 1.26 for paraoxon; guinea pigs: 12.75 +/- 0.88 for parathion and 15.02 +/- 3.84 for paraoxon). In the lungs of both species, there was a linear relation between y, the percentage of cholinesterase inhibition induced by either organophosphate, and X, the total amount of drug taken up by the lung tissue (in nmol/g/18 min). The following equations were obtained: y = 0.128 x + 0.979 (R2 = 0.89, p < 0.001 for paraoxon); y = 0.120 x - 6.57 (R2 = 0.82, p < 0.005 for parathion). No difference was observed between the two organophosphates. After treatment with the cytochrome P450 inhibitor piperonyl butoxide, the above relations ceased to apply, but this treatment did not influence the kinetics of paraoxon and parathion uptake. The IC50 value calculated for paraoxon, i.e., the paraoxon concentration required to produce 50% inhibition of lung cholinesterase activity, was similar for guinea pigs (2.22 10(-7) +/- 0.22 M) and rabbits (2.36 10(-7) +/- 0.24 M). In conclusion, the biexponential evolution of the velocity of paraoxon and parathion uptake by the lungs thus demonstrates the presence of two pools. The lower extraction ratios calculated for rabbit lungs reflect the lower initial uptake velocity of the second compartment. In the range of concentrations investigated in guinea pigs, no saturable mechanism could be demonstrated for paraoxon and parathion. Cytochrome P450-related lung metabolic activity, through which parathion is converted to paraoxon, appears as a major step in parathion-induced lung cholinesterase inhibition, although it does not appear to affect parathion toxicokinetics [less ▲]

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See detailAssessment of residual insulin secretion in diabetic patients using the intravenous glucagon stimulatory test: methodological aspects and clinical applications.
Scheen, André ULg; Castillo, M. J.; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(6), 397-406

Defective insulin secretion plays a crucial role in insulin-dependent (Type 1) and non-insulin-dependent (Type 2) diabetes mellitus as well as in many secondary forms of the disease. Glucagon is a potent ... [more ▼]

Defective insulin secretion plays a crucial role in insulin-dependent (Type 1) and non-insulin-dependent (Type 2) diabetes mellitus as well as in many secondary forms of the disease. Glucagon is a potent stimulus for the islet beta-cell, and intravenous bolus injection of 1 mg glucagon has been widely used to assess endogenous insulin secretion for clinical or research purposes. Plasma C-peptide levels (less commonly insulin) are usually measured immediately before and 6 min after glucagon injection. The C-peptide response to glucagon is well-correlated with the beta-cell response to mixed meals or other stimuli commonly used to characterize endogenous insulin secretion (oral or intravenous glucose, standard meals, arginine, etc.) and has the advantage of shorter duration and simple standardization. The glucagon test shows good intra-subject reproducibility, although in diabetic patients it may be influenced by variable prevailing blood glucose levels. Several applications of the glucagon test have been developed. In Type 1 diabetes, the glucagon test has been used to discriminate between patients with and without residual insulin secretion. This can be especially important during the first few months, or even years, following initiation of insulin therapy when attempts to stop the immunological destruction of the beta-cell are made. Assessment of endogenous insulin secretion is also important after pancreas or islet transplantation. In patients with Type 2 diabetes mellitus, in which residual endogenous insulin secretion is common, characterization of the disease may help in the choice of therapy for the individual patient (insulin, sulphonylureas or combined therapy). Thus, the glucagon test is a simple, reliable and useful tool for clinical evaluation of diabetes mellitus. [less ▲]

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See detailLes tempêtes (tempêtes extratropicales, cyclones tropicaux et tornades)
Erpicum, Michel ULg; Van Hoof, Th.

in Le point sur le I de Géographie (Soc géogr de Liège) (1996), 4

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See detailDistribution of inorganic carbon and related parameters in surface waters of the English Channel during spring 1994
Frankignoulle, Michel; Elskens, Marc; Biondo, Renzo ULg et al

in Journal of Marine Systems (1996), 7

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See detailHomogeneous Lyapunov Functions and Necessary Conditions for Stabilization
Sepulchre, Rodolphe ULg; Aeyels, D.

in Journal of mathematics for control, signal and systems (1996), 9(1), 34-58

We provide necessary conditions for the stabilization of nonlinear control systems with the additional requirement that a time-invariant homogeneous Lyapunov function exists for the closed-loop system.

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See detailClinical pharmacokinetics of metformin.
Scheen, André ULg

in Clinical Pharmacokinetics (1996), 30(5), 359-71

The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus (NIDDM). Considerable renewal of interest in this ... [more ▼]

The biguanide metformin (dimethylbiguanide) is an oral antihyperglycaemic agent widely used in the management of non-insulin-dependent diabetes mellitus (NIDDM). Considerable renewal of interest in this drug has been observed in recent years. Metformin can be determined in biological fluids by various methods, mainly using high performance liquid chromatography, which allows pharmacokinetic studies in healthy volunteers and diabetic patients. Metformin disposition is apparently unaffected by the presence of diabetes and only slightly affected by the use of different oral formulations. Metformin has an absolute oral bioavailability of 40 to 60%, and gastrointestinal absorption is apparently complete within 6 hours of ingestion. An inverse relationship was observed between the dose ingested and the relative absorption with therapeutic doses ranging from 0.5 to 1.5 g, suggesting the involvement of an active, saturable absorption process. Metformin is rapidly distributed following absorption and does not bind to plasma proteins. No metabolites or conjugates of metformin have been identified. The absence of liver metabolism clearly differentiates the pharmacokinetics of metformin from that of other biguanides, such as phenformin. Metformin undergoes renal excretion and has a mean plasma elimination half-life after oral administration of between 4.0 and 8.7 hours. This elimination is prolonged in patients with renal impairment and correlates with creatinine clearance. There are only scarce data on the relationship between plasma metformin concentrations and metabolic effects. Therapeutic levels may be 0.5 to 1.0 mg/L in the fasting state and 1 to 2 mg/L after a meal, but monitoring has little clinical value except when lactic acidosis is suspected or present. Indeed, when lactic acidosis occurs in metformin-treated patients, early determination of the metformin plasma concentration appears to be the best criterion for assessing the involvement of the drug in this acute condition. After confirmation of the diagnosis, treatment should rapidly involve forced diuresis or haemodialysis, both of which favour rapid elimination of the drug. Although serious, lactic acidosis due to metformin is rare and may be minimised by strict adherence to prescribing guidelines and contraindications, particularly the presence of renal failure. Finally, only very few drug interactions have been described with metformin in healthy volunteers. Plasma levels may be reduced by guar gum and alpha-glucosidase inhibitors and increased by cimetidine, but no data are yet available in the diabetic population. [less ▲]

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See detailLe cas clinique du mois. Hemochromatose genetique
Collignon, Nathalie ULg; Delwaide, Jean ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1996), 51(2), 150-153

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See detailChemotaxis-Promoting and Adhesion Properties of Human Tonsillar Follicular Dendritic Cell Clusters
Bouzahzah, F.; Antoine, Nadine ULg; Simar, Léon ULg et al

in Research in Immunology (1996), 147(3, Mar-Apr), 165-73

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role ... [more ▼]

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role played by FDCs in attracting and binding cells. FDCs prepared from human tonsils by mild separation techniques appeared in the form of clusters (FDC clusters), where, via cytoplasmic extensions, they enveloped lymphoid cells. Using Boyden's chambers, we demonstrated that these FDC clusters produced one or more chemoattractants capable of inducing chemotaxis of lymphoid cells. Supernatants of FDC cluster cultures also exerted a chemotaxis-promoting effect. FDC clusters induced true chemotaxis, not merely chemokinesis due to cell activation. They secreted a substance or substances that stuck to the substrate (a cellulose filter) and thus induced haptotaxis. B as well as T cells were attracted, but B cells apparently required the presence of T cells to respond fully to the chemoattractant(s). Subtypes of B cells (IgD+ and IgD-) and T cells (CD4+, CD8+, CD57+ AND CD57-) were tested and all were attracted. Since purified lymphoid cells did not induce these phenomena, FDCs were suspected to do so. FDCs have been shown to establish contact with lymphoid cells. Here we have determined that CD4+ T cells adhere in greater number to FDC clusters than do CD8+ T cells. We thus propose that FDCs specifically contribute to construction of lymph follicles by attracting and determining their cell composition. [less ▲]

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See detailThe frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate
Kaye, O.; Beckers, C. C.; Paquet, P. et al

in Journal of Rheumatology (1996), 23(2), 253-257

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well ... [more ▼]

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well as their demographic, clinical and biological characteristics. METHODS: Ninety-one patients with RA receiving 9.5 mg/wk of methotrexate (MTX) were compared for an average observation time of 18 months to 130 matched patients with RA treated with various drugs excluding MTX. RESULTS: Whether receiving MTX or not, 5.4% of patients with RA developed a clinical cutaneous vasculitis. There were significant differences between both groups for 2 variables only: a higher percentage of polyneuropathies and a higher level of immune complex-plasma levels in non-MTX patients. The immunohistological analysis did not differentiate both groups. CONCLUSION: The percentage of cutaneous vasculitis that developed under MTX therapy was not different from that occurring as a natural complication of longstanding severe RA. [less ▲]

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See detailFibres alimentaires chez le chien : I. Définition et composition chimique
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1996), 140

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and ... [more ▼]

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and the principal chemical constituents are described along with the potential applications in the agro-industry and therapy. [less ▲]

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See detailEffets de l'interleukine 1 sur les chondrocytes humains cultivés en agrégats
Bassleer, Corinne; Jaspar, Jean-Marie; Reginster, Jean-Yves ULg et al

in Revue du Praticien (La) (1996), 46(6 Spec No), 31-34

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See detailBrain thiamine, its phosphate esters, and its metabolizing enzymes in Alzheimer's disease.
Mastrogiacomo, Frank; Bettendorff, Lucien ULg; Grisar, Thierry ULg et al

in Annals of Neurology (1996), 39

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See detailChanges in breath 13CO2/12CO2 during exercise of different intensities.
Gautier, J. F.; Pirnay, Freddy ULg; Lacroix, M. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1996), 81(3), 1096-102

The measurement of breath 13CO2/12CO2 is commonly used during exercise to evaluate the oxidation rate of exogenous carbohydrates enriched in 13C. The aim of this study was to investigate whether exercise ... [more ▼]

The measurement of breath 13CO2/12CO2 is commonly used during exercise to evaluate the oxidation rate of exogenous carbohydrates enriched in 13C. The aim of this study was to investigate whether exercise itself affects the 13C/12C ratio in expired air CO2 in relation to exercise intensity. The relative abundance of 13C and 12C in expired air CO2 was determined by isotoperatio mass spectrometry and expressed as delta 13C (in %o) by using Craig's formula and calibrated standards. Five healthy young men exercised on a treadmill after an overnight fast during > or = 105 min on four occasions and in a randomized order. Work rates were performed at approximately 30, 45, 60, and 75% of their maximal O2 uptake (VO2max). Delta 13C in expired air CO2 and respiratory exchange ratio (RER) were determined every 15 or 30 min during exercise. At 30 and 45% VO2max, a slight and not statistically significant increase in delta 13C was observed at 30 min. In contrast, at 60 75% VO2max, the rise was statistically significant and averaged 0.83 and 0.99%o, respectively. Average delta 13C (between 0 and 105 min) progressively increased with the intensity of exercise. Individual values of delta 13C and RER were positively correlated (r = 0.653, P = 0.002) as were values of delta 13C and endogenous carbohydrates utilized (r = 0.752, P < 0.001). Factitious or "pseudooxidation" of a 13C-enriched exogenous glucose load (indeed noningested) was calculated from the changes in expired air delta 13C. Over the whole period of exercise it was not statistically significant at 30 and 40% VO2max. However, over the first 60 min of exercise, such pseudooxidation of exogenous glucose was significant at 30 and 45% VO2max. In conclusion, by modifying the mix of endogenous substrates oxidized, exercise at 60% VO2max and above significantly increases the 13C/12C ratio in expired air CO2. At these intensities, this could lead to overestimation of the oxidation of 13C-labeled substrates given orally. At lower intensities of exercise, such overestimation is much smaller an affects mainly the values recorded during the initial part of the exercise bout. [less ▲]

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See detailMeasurement of tomato firmness by using a non-destructive mechanical sensor
Lesage, Patrick; Destain, Marie-France ULg

in Postharvest Biology & Technology (1996), 8

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate ... [more ▼]

A non-destructive mechanical sensor (Cantifruit) was designed to measure the firmness of tomatoes. It consists of a small plunger constrained to penetrate slightly into the fruits, by using an accurate lever mechanism. A highly significant correlation exists between firmness measurements performed with this device and the Stable Micro Systems (SMS), fitted with the same plunger dimaeter. Using the Cantifruit, data related to firmness variability and changes are easily obtained. The firmness of tomatoes varies about 12 % around its circumference. In a single lot of tomatoes picked at the same time, the variability may exceed 25 %. If the tomatoes are stored at 4-5 °C and 92-99 % relative humidity (RH), their firmness decreases by about 20 % over ten days. [less ▲]

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See detailOpera Latina, le CD-ROM de textes latins classiques du LASLA
Purnelle, Gérald ULg

in Le Médiéviste et l’Ordinateur (1996), 33(printemps), 21-25

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See detailAn improved preparation method of benzyl and thenyl triphenylphosphonium salt
Zhang, Jian-Xin; Dubois, Philippe ULg; Jérôme, Robert ULg

in Synthetic Communications (1996), 26(16), 3091-3095

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine ... [more ▼]

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine can also be converted within high yields to phosphonium salts by removing the formed water by azeotropic distillation. Solvent (methylene chloride, chloroform and acetonitrile) and temperature have been chosen in close relation to the alcohol reactivity. Purification is straightforward and yields are relatively high. [less ▲]

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See detailMyocellular Enzyme Leakage, Polymorphonuclear Neutrophil Activation and Delayed Onset Muscle Soreness Induced by Isokinetic Eccentric Exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Deby-Dupont, G. et al

in Archives of Physiology & Biochemistry (1996), 104(3), 322-9

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product ... [more ▼]

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle contractions. However, the hypothesized interplay between muscle damage, increased PGE2 production, DOMS sensations, and reduced isokinetic muscle performance was not substantiated by the present results. [less ▲]

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See detailMicroscopic observation of the retinal photoreceptor layer of the common barbel (Teleostei: Cyprinidae)
Compère, Philippe ULg; Poncin, Pascal ULg

in Belgian Journal Of Zoology (1996), 126(1), 49-56

Light and electron microscopic observations show that cones-belonging to four types are present in the retina of the common barbel Barbus barbus (L.): short single cones, long single cones, twin cones ... [more ▼]

Light and electron microscopic observations show that cones-belonging to four types are present in the retina of the common barbel Barbus barbus (L.): short single cones, long single cones, twin cones, and unequal double cones. They do not exhibit any particular arrangement. Estimates of cone density suggest that the common barbel has multichromatic vision but of low acuity and that no difference exists between the lower and the upper parts of the retina. Both cone density (approximately 3000 units/mm(2)) and the proportion of double cones to single cones (approximately 1:3) are low. The view that the barbel has an inferior colour vision is in good agreement with the fact that this species is active mainly at twilight, but with diurnal activity during spawning. [less ▲]

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See detailLe clonage par transfert de noyau dans l'espece bovine: resultats et perspectives.
Ectors, Fabien ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(12), 493-9

A all in vitro cloning technique was developed in which the reconstituted embryos from the first cycle nuclear transfer (cloning) were used as blastomere donor for the second cycle nuclear transfer ... [more ▼]

A all in vitro cloning technique was developed in which the reconstituted embryos from the first cycle nuclear transfer (cloning) were used as blastomere donor for the second cycle nuclear transfer (recloning). Such method permitted to produce 14.5% of morulae and 14.9% of blastocysts after the first and second cycles of nuclear transfer, respectively. The rates of birth obtained after transfer of such embryos were 21.4% et 20.8% for first and second cycles respectively, corresponding to 6 et 5 calves for 28 et 24 transferred embryos. Unfortunately, gestation pathologies and an increase of birth weights were observed. It seems that the in vitro presence of gametes and/or embryos may be responsible of an alteration in the control of gene expression. [less ▲]

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See detailLa réforme du premier degré : Un défi à relever malgré un contexte difficile
Beckers, Jacqueline ULg; Stegen, Pierre

in Education-Formation (1996), 244

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See detailAlterations in the ultradian oscillations of insulin secretion and plasma glucose in aging.
Scheen, André ULg; Sturis, J.; Polonsky, K. S. et al

in Diabetologia (1996), 39(5), 564-72

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with ... [more ▼]

Normal insulin secretion includes oscillations with a period length of 80-150 min which are tightly coupled to glucose oscillations of similar period. To determine whether normal aging is associated with alterations in these ultradian oscillations, eight, modestly overweight, older men (65 +/- 5 years) and eight weight-matched young control subjects (25 +/- 4 years) were studied during 53 h of constant glucose infusion. Blood samples were collected every 20 min and insulin secretion rates were calculated by deconvolution. Ultradian oscillations of glucose and insulin secretion were evident in both groups. Pulse frequency was similar for glucose and insulin secretion, and was not affected by age. The absolute amplitude of the glucose oscillations was similar in both groups but their relative amplitude was slightly dampened in the older adults. Both the absolute and the relative amplitudes of insulin secretory oscillations were markedly reduced in the older subjects. The normal linear increase in the amplitude of insulin oscillations occurring with increasing amplitudes of glucose oscillations was still present in the older adults but analysis of covariance indicated that the slope was significantly lower than in the young control subjects (p < 0.0005), reflecting a decreased responsiveness of the beta cell to glucose changes. The temporal concordance between insulin and glucose oscillations, as estimated by pulse concomitancy and cross-correlation, was also lower in older subjects. The similarities between the alterations in the ultradian oscillations of insulin secretion and glucose in older healthy adults and those occurring in diabetic patients suggest that an impairment of beta-cell function may play a primary role in the deterioration of glucose tolerance in aging. [less ▲]

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See detailNouveaux developpements en selection animale.
Burny, A.; Portetelle, Daniel ULg; Renaville, Robert ULg

in Agricontact (1996), (287),

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See detailEffets toxiques de l’ozone atmosphérique sur le système respiratoire. Brève revue des connaissances actuelles
Delaunois, A.; Gustin, Pascal ULg; Nemmar, R. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailLes morphinomimétiques en réanimation
Lamy, Maurice ULg; Joris, Jean ULg; Damas, Pierre ULg et al

in Revue Janssen-Cilag (1996)

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See detailHybridization of 2,659 Clostridium Perfringens Isolates with Gene Probes for Seven Toxins (Alpha, Beta, Epsilon, Iota, Theta, Mu, and Enterotoxin) and for Sialidase
Daube, Georges ULg; Simon, Patricia ULg; Limbourg, Bernard et al

in American Journal of Veterinary Research (1996), 57(4), 496-501

OBJECTIVE--To genetically characterize Clostridium perfringens isolates for association of pathologic type with various diseases. DESIGN--Prospective study. SAMPLE POPULATION--2,659 C perfringens isolates ... [more ▼]

OBJECTIVE--To genetically characterize Clostridium perfringens isolates for association of pathologic type with various diseases. DESIGN--Prospective study. SAMPLE POPULATION--2,659 C perfringens isolates from various nonhuman animals species, human beings, and foods. PROCEDURE--Colony hybridization with DNA probes for 7 toxin (alpha, beta, epsilon, iota (subunits a and b), theta, mu, and enterotoxin) genes and 1 sialidase gene were performed to group the isolates by pathologic type. RESULTS--Enterotoxin-negative type-A isolates were the most common (2,575/2,659), were isolated from all sources, and were separated into 5 pathologic types. In cattle and horses with enterotoxemia, essentially only these pathologic types were identified. The enterotoxin-negative isolates of types C or D each had a single pathologic type. Type-C isolates were isolated only from swine with necrotic enteritis and type-D isolates from small ruminants with enterotoxemia, except that 1 type-D isolate was also found from a healthy fish. Type-B or -E isolates were not found. Among the 47 enterotoxin-positive isolates, 5 isolates from sheep or deer were type D and the other 42 were type A. These 42 isolates were grouped into 3 pathologic types: 1 type was isolated from samples of almost all origins, but the other 2 types were found in only 5 fish, 4 human beings, and 1 dog. CONCLUSIONS AND CLINICAL RELEVANCE--Genetic characterization of these isolates allowed identification of 11 different pathologic types. This approach may be useful in molecular diagnosis and prophylaxis of clostridial disease. [less ▲]

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See detailIntensive culture of juvenile and adult Eurasian perch (P. fluviatilis): effect of major biotic and abiotic factors on growth
Mélard, Charles ULg; Kestemont, P.; Grignard, J. C.

in Journal of Applied Ichthyology (1996), 12

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See detailQuantitative Densitometric Evaluation of Harpagoside in the Secondary Roots of Harpagophytum procumbens D.C.
Poukens-Renwart, Pascale; Tits, Monique ULg; Angenot, Luc ULg

in Journal of Planar Chromatography- Modern TLC (1996), 9(May/June), 199-202

Harpagophytum procumbens D.C. (Devil's Claw) secondary roots are used in Europe as a home remedy for lack of appetite, dyspeptic complaints, and in supportive therapy for degenerative disorders of the ... [more ▼]

Harpagophytum procumbens D.C. (Devil's Claw) secondary roots are used in Europe as a home remedy for lack of appetite, dyspeptic complaints, and in supportive therapy for degenerative disorders of the locomotor system. The main characteristic iridoid glucoside of the plant is harapagoside. An HPTLC method has been developed for the quantitative determination of harpagoside in the secondary roots and extracts of this plant. The mobile phase used is an optimized version of one described in the literature.It furnished the most homogenous spots for quantitative densitometric evaluation ( at lambda= 286 nm, the wavelenght of maximum absorption for harapgoside).The results have been compared with those obtained afetr visualization with sulfuric acid-vanillin reagent and those obtained using a previously published HPLC method; To check that separation was complete, the spectra of harpagoside obtained from Devil's Claw extracts before and after visualization were superimposed on thos of harpagoside standard. [less ▲]

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See detailTabac et maladie parodontale
Geerts, Sabine ULg

in Actualités Dentaires de l'Université de Liège (1996), 19

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation ... [more ▼]

Le tabac est un facteur aggravant la parodontite. Beaucoup d'études cliniques ont été menées et ont souvent montré des résultats contradictoires. Cet article est une revue de littérature sur la relation entre le tabagisme et la parodontite. [less ▲]

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See detailL’ὕβρις dans le mythe d'Idas et Lyncée
Renaud, Jean-Michel ULg

in Uranie : Mythes et Littératures (1996), 6

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See detailLa réforme du premier degré en Communauté française de Belgique veut relever le défi d'une pédagogie de la réussite
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1996), 5-6

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See detailDensitometric Evaluation of Gentiopicroside in the Roots of Gentiana lutea L.
Bodart, Patricia; Poukens-Renwart, Pascale; Wauters, Jean-Noël ULg et al

in Journal of Planar Chromatography- Modern TLC (1996), 9(March/April), 143-145

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a ... [more ▼]

As no satisfactory method existed for the separation of gentiopicroside from other components of gentian roots, we have decided to undertake some experiments.In this communication, we report the use of a novel mobile phase and a different detection system. Our HPTLC method is a fast and reliable procedure which may be used for quantification of gentiopicroside in roots and extracts of Gentiana lutea, whether for routine analysis or for studying stability. The TLC method is also compared with an HPLC method. [less ▲]

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See detailEnhancement of nuclear receptor transcriptional signalling.
Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 39-45

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which ... [more ▼]

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins. [less ▲]

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See detailPratiques d'auto-formation : une enquête en communauté française de Belgique
Denis, Brigitte ULg

in Cahiers d'Etudes du C U E E P (1996), 32-33

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See detailModulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen
Willardgallo, Ke.; Delmellewibaut, C.; Segurazapata, I. et al

in Aids Research and Human Retroviruses (1996), 12(8),

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See detailAugustus Latinus. Purisme, pouvoir, politique et idéologie sous Auguste
Rochette, Bruno ULg

in Bulletin de l'Institut Historique Belge de Rome (1996), 66

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See detailContamination of European otters (Lutra lutra) by PCB congeners and organochlorinated pesticides in the wetlands of western France
Tans, Michael; Hugla, Jean Louis; Libois, Roland ULg et al

in Netherlands Journal of Zoology (1996), 46(3-4), 326-336

During the forty years, otter (Lutra lutra) populations have severely declined over much of Europe. One of the main regression factors appears to be pollution by organochlorine xenobiotics, especially ... [more ▼]

During the forty years, otter (Lutra lutra) populations have severely declined over much of Europe. One of the main regression factors appears to be pollution by organochlorine xenobiotics, especially PCBs. The present study took place in France, in the wetlands of the Atlantic border, where otter populations are considered to the stable. Muscle, pericaudal fat, and liver of 33 otters were analysed for 22 PCB congeners and organochlorine pesticides. The mean concentrations of organochlorinated pesticides in samples are relatively low (from 0 to 5.71 mg/kg lipid weight). The PCB concentrations are higher (mean in muscular tissue: 26.19 mg/kg lipid weight), but still remain low compared to similar samples from other countries. The relation between PCB concentration and physiological variables is discussed. Congener specific analysis shows an important contamination due to highly chlorinated congeners and a poor contaminatin due to low chlorinated congeners. Potential hazards due to organochlorinated compounds are also discussed. [less ▲]

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See detailUsefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
Daubresse, Jean-Claude; Kolanowski, J.; Krzentowski, G. et al

in Obesity Research (1996), 4(4), 391-6

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent ... [more ▼]

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent diabetics, moderately obese (BMI = 30 - 39 kg/m2), were given for an 8-week period either placebo (P) or fluoxetine (F), a specific serotonin reuptake inhibitor, in addition to their usual antidiabetic treatment. Thirty-nine of them received 60 mg fluoxetine a day and 43 were given the placebo. At admission, both groups had similar weight excess, metabolic control and serum lipid values. In comparison with the P-treated subjects, those treated with fluoxetine (F) lost more weight after 3 weeks (-1.9 vs. -0.7 kg, p < -0.0009) and after 8 weeks (-3.1 vs. -0.9 kg, p < 0.0007). Fasting blood glucose decreased in group F after 3 weeks (-1.5 vs -0.4 mmol/L, p < 0.003) and after 8 weeks (-1.7 vs. -0.02 mmol/L, p < 0.0004). HbAlc decreased from 8.5% to 7.7% in group F and from 8.6% to 8.3% in group P (p = 0.057). Mean triglyceride level was also reduced in group F after 8 weeks (p = 0.042). Fasting C-peptide did not change in either group, but fasting insulin values decreased in group F after 3 weeks (p < 0.02) and after 8 weeks (p < 0.05). The insulin/C-peptide molar ratio decreased significantly in group F after 3 weeks (p < 0.04) and after 8 weeks (p < 0.05) in comparison with group P. The drug was generally well tolerated and no major side effects were reported. In conclusion, the addition of fluoxetine to the usual oral hypoglycemic agent therapy might be beneficial in obese non-insulin-dependent diabetics, at least on a short-term basis. [less ▲]

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See detailA site with foliicolous lichens in Belgium
van den Boom, Pieter; Sérusiaux, Emmanuël ULg

in Belgian Journal of Botany (1996), 129

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See detailDes pèlerins latins en Terre Sainte. Rencontre de langues et de cultures
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1996), 66

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See detailExpansive benign lesions: treatment by laser.
Smets, Mireille; NISOLLE, Michelle ULg; Bassil, Salim et al

in European Journal of Obstetrics and Gynecology (1996), 65(1), 101-5

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ... [more ▼]

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ablation using the Nd-YAG laser and the advantages of the preoperative use of GnRH agonist therapy. They report their results in a series of 746 patients treated for meno-metrorrhagia (366 cases of myomectomy and 380 cases of endometrial ablation). [less ▲]

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See detailExhaustion of blood glucose response and enhancement of insulin response after repeated glucagon injections in type-2 diabetes: potentiation by progressive hyperglycemia.
Castillo, M. J.; Scheen, André ULg; Paolisso, G. et al

in Annales d'Endocrinologie (1996), 57(5), 395-402

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients ... [more ▼]

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients, three i.v. glucagon (1 mg) injections were given as a bolus at two-hour intervals. In the hour preceding each glucagon injection, 6 patients received saline and they were tested at near-baseline blood glucose levels, while 8 patients received a glucose-controlled glucose infusion and they were tested at increasing blood glucose levels (7.5 +/- 0.2, 12.9 +/- 0.5 and 18.7 +/- 0.7 mmol/l). Blood samples were collected at 0, 3, 5, 10, 15, 30 and 60 min after each glucagon injection. RESULTS: In the patients tested at near-baseline blood glucose levels, the blood glucose rise induced by glucagon was smaller after repeated injections. By contrast, the B-cell response to glucagon was well preserved. In the patients tested at increasing blood glucose levels, the blood glucose response to glucagon was abolished after repeated injections. By contrast, the B-cell response was significantly potentiated. The respective areas under the curve of plasma insulin levels in response to glucagon were 563 +/- 72, 1047 +/- 154 and 1844 +/- 305 m U x 30 min/l (p < 0.001). CONCLUSION: In Type-2 (non-insulin-dependent) diabetic patients, repeated glucagon injections, even when administered in a short (4 h) period of time, do not exhaust the B-cell. Endogenous insulin secretion is even potentiated at increasing blood glucose levels. By contrast, the hyperglycemic response to glucagon is significantly abolished, particularly at high blood glucose levels. [less ▲]

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See detailThe effects of dietary crude protein on growth of the Eurasian perch Perca fluviatilis
Fiogbe, E. D.; Kestemont, P.; Mélard, Charles ULg et al

in Aquaculture (1996)

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See detailTwo dimensional self-organized transitions for propagation in random media
Ausloos, Marcel ULg; Vandewalle, Nicolas ULg; Cloots, Rudi ULg

in Czechoslovak Journal of Physics (1996), 46(Suppl. 4), 2277-2278

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the ... [more ▼]

A simple so-called dynamic epidemic model, for the evolution of an advancing interface through a two-dimensional medium containing mobile impurities is investigated. A short range repulsion between the front and the impurities leads to an aggregation process along the front, and to trapping of aggregates. The pattern of trapped impurities is found to be self-organized. The critical concentration of impurity for growth blocking on a square lattice is 0..56. The kinetics of this self-organization is analyzed and discussed. [less ▲]

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See detailExpression of the Mr 67,000 laminin receptor is an adverse prognostic indicator in human thyroid cancer: an immunohistochemical study.
Basolo, F.; Pollina, L.; Pacini, F. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1996), 2(10), 1777-80

Increased expression of the Mr 67,000 laminin receptor (LR) is a consistent event which appears as cancer cells acquire an invasive and metastatic phenotype. The Mr 67,000 LR is one of the many laminin ... [more ▼]

Increased expression of the Mr 67,000 laminin receptor (LR) is a consistent event which appears as cancer cells acquire an invasive and metastatic phenotype. The Mr 67,000 LR is one of the many laminin-binding proteins able to interact with the major glycoprotein of basement membranes, laminin. The recent development of a specific monoclonal antibody directed against the Mr 67,000 LR MLuC5 has allowed us to study large retrospective groups of human cancers with the aim of correlating the Mr 67,000 LR expression to the clinical, pathological, and survival data of the patients. A significant correlation has already been established between the increased expression of Mr 67,000 LR and survival of patients with breast, colon, ovary, lung, and endometrial cancers. In this study, we investigated the possibility that the detection of Mr 67,000 LR in thyroid human cancers could also be of prognostic value. We analyzed the expression of Mr 67,000 LR with immunohistochemistry using MLuC5 antibodies in paraffin sections of 40 benign and 170 malignant thyroid human tumors. We found that Mr 67,000 LR was not usually detectable in normal thyroid tissues adjacent to the lesion. Only 3 of the 40 thyroid adenomas examined (7.5%) presented cells positive for Mr 67,000 LR. For the malignant thyroid tumors examined, we found that 22.3% of papillary thyroid carcinomas, 38% of follicular thyroid carcinomas, 40% of poorly differentiated carcinomas, 25% of medullary carcinomas, and 58.3% of anaplastic carcinomas expressed a high level of Mr 67,000 LR. Although no correlation between the Mr 67,000 LR expression and survival was found in patients with follicular thyroid carcinomas, papillary thyroid carcinomas, anaplastic carcinomas, and medullary carcinomas, there was a significant correlation in primary thyroid cancers. Our data represent the first extensive study of the Mr 67,000 LR expression in human thyroid cancers and strongly suggest that its detection could be of prognostic value in the investigation of primary thyroid cancers. [less ▲]

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See detailFinite element modelling of the competition between shear bands in the early stage of thrusting : Strain localisation and constitutive law influence
Barnichon, Jean-Dominique; Charlier, Robert ULg

in Special Publication - Geological Society of London (1996), 99

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See detailPeptide G, containing the binding site of the 67-kDa laminin receptor, increases and stabilizes laminin binding to cancer cells.
Magnifico, A.; Tagliabue, E.; Buto, S. et al

in Journal of Biological Chemistry (1996), 271(49), 31179-84

We investigated the effect of peptide G, a synthetic peptide derived from the sequence of the 37-kDa laminin receptor precursor, on the interaction of laminin in two tumor cell lines one of which produces ... [more ▼]

We investigated the effect of peptide G, a synthetic peptide derived from the sequence of the 37-kDa laminin receptor precursor, on the interaction of laminin in two tumor cell lines one of which produces laminin and one of which does not. Addition of peptide G to the culture medium induced a significant increase in the amount of endogenous laminin detectable on the cell membrane of both cell lines. Moreover, pretreatment of exogenous laminin with peptide G dramatically increased laminin binding on both cell lines. Kinetics analysis of membrane-bound labeled laminin revealed a 3-fold decrease in the kd of peptide G-treated laminin compared with untreated or unrelated or scrambled peptide-treated laminin. Moreover, the affinity constant of peptide G-treated laminin increased 2-fold, with a doubling of the number of laminin binding sites, as determined by Scatchard analysis. Expression of the VLA6 integrin receptor on the cell membrane increased after incubation with peptide G-treated laminin. However, the lower binding inhibition of peptide G-treated laminin after anti-VLA6 antibody or cation chelation treatment indicates that membrane molecules in addition to integrin receptors are involved in the recognition of peptide G-modified laminin. These "new" laminin-binding proteins also mediated cell adhesion to laminin, the first step in tumor invasion. Together, the data suggest that peptide G increases and stabilizes laminin binding on tumor cells, involving surface receptors that normally do not take part in this interaction. This might explain the abundant clinical and experimental data suggesting a key role for the 67-kDa laminin receptor in the interaction between cancer cells and the basement membrane glycoprotein laminin during tumor invasion and metastasis. [less ▲]

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See detailTheory of the thermal conductivity of metallic localized spin compounds in a magnetic field
Rassili, Ahmed ULg; Ausloos, Marcel ULg

in Journal of Magnetism & Magnetic Materials (1996), 163(1-2), 153-163

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint ... [more ▼]

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint impurity and phonon scattering processes together with the localized spin influence is shown. Remarkable features are found at low temperature and near the critical transition. An increase of conductivity with field near T-C is discussed. It is also argued that a coherent effect due to the field is the cause of the thermal conductivity enhancement at low temperature. The magneto-thermal conductivity is shown at different temperatures. [less ▲]

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See detailEffect of serotonergic blockade on calf pulmonary function after the intravenous administration of 3-methylindole
Linden, Annick ULg; Desmecht, Daniel ULg; Vandenput, Sandrina ULg et al

in Journal of Comparative Pathology (1996), 114(4), 361-371

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked ... [more ▼]

This study was designed to investigate whether 3-methylindole (3-Mi), a tryptamine analogue, could cause pulmonary injury in calves other than by cytotoxicity. Injection of 3-Mi resulted in a marked increase of respiratory rate, decrease of tidal volume and increase in minute ventilation. Pulmonary mechanics values were also profoundly affected, lung dynamic compliance being reduced to approximately one-third of its baseline value and total pulmonary resistance being increased two-fold. Arterial oxygen partial pressure was dramatically reduced. Successive challenges with 3-Mi after physiological saline pretreatment resulted in quantitatively identical alterations of pulmonary function values. Conversely, all these ventilatory, mechanical and gas exchange changes were abolished by pretreatment with serotonergic antagonists. It was concluded that intravenous administration of 3-Mi to healthy calves induced immediate and reversible bronchoconstriction which affected both central and peripheral airways. Because the effect was abolished by pretreatment with antiserotonin drugs, it is suggested that 3-Mi acts either directly by stimulating serotonergic receptors or indirectly through the release of serotonin from platelets. Current concepts of the physiopathological cascade underlying the toxicity of 3-Mi should, therefore, be re-evaluated in the light of this pharmacological mechanism. [less ▲]

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See detailIntestinal Digestibility Of Rumen Undegraded N Of Concentrates Measured By The Mobile Nylon Bag Technique
Beckers, Yves ULg; Thewis, André ULg; Maudoux, Benoît

in Animal Feed Science & Technology (1996), 61(1-4), 305-323

Two experiments were carried out on sheep to measure the effects of some factors of the mobile nylon bag (MNB) technique on the intestinal digestibility (DgI) of rumen undegraded N of meat and bone meal ... [more ▼]

Two experiments were carried out on sheep to measure the effects of some factors of the mobile nylon bag (MNB) technique on the intestinal digestibility (DgI) of rumen undegraded N of meat and bone meal (MBM), soybean meal (SBM) and wheat bran (WB). The pore size of the nylon cloth (IO and 42.5 pm) influenced (P < 0.05) DgI of SBM and MBM N irrespective of the site of recovery of the bags (ileum and faeces) and the incubation time of concentrate feeds in the rumen (0, 2, 4, 8, 16 and 24 h). The faecal recovery of the bags increased (P < 0.05) DgI of SBM N in comparison with ileal recovery. The opposite was found with WB incubated 4, 8, 16 and 24 h in the rumen. DgI of MBM N was not influenced by site of bag recovery (P > 0.05). Increasing incubation times in the rumen decreased (P < 0.05) DgI of undegraded feed N. The total tract digestibility (rumen plus intestines) was independent of incubation time in the rumen for MBM and SBM, excepted for SBM incubated 4 or 8 h in the rumen when bags were collected in the ileum. Previous ruminal incubation of WB for 4, 8, 16 and 24 h increased (P < 0.05) the amount of N digested in the total tract in comparison with unincubated WB and WB incubated for only 2 h. In the second experiment, residues obtained from the incubation of the feeds in the rumen (0, 2, 4, 8, 16, 24 and 48 h) were mixed in different proportions in order to obtain the true fraction of the undegraded feed in the rumen. This method was based on the DM degradability of the concentrate feeds and the outflow rate constant of feeds from the rumen, supposed equal to 6%h-‘. Bags containing feeds mixed according to this method were incubated in a solution of pepsin-HCl for 0, 1, 2 and 3 h to simulate abomasal digestion and the DgI of N was measured afterwards with the MNB technique. Increasing action of pepsin led to higher digestibilities of N at this stage (P < 0.05) but decreased the digestibility of N in the intestines excepted for MBM incubated in pepsin-HCl for 3 h and in any case for SBM. However, the omission of the incubation in pepsin had little influence on the amount of N postruminally digested. [less ▲]

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See detailWhere is the Algorithmic Support?
Wolper, Pierre ULg

in ACM Computing Surveys (1996), 28(4es), 58

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See detailAcute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Louis, Renaud ULg; Radermecker, Maurice ULg

in European Respiratory Journal (1996), 9(7), 1414-20

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in ... [more ▼]

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in the specific conductance (sGaw) and forced expiratory volume in one second (FEV1) in 12 asthmatics and 12 normal subjects after inhalation of doubling doses of PAF (15-120 micrograms) and methacholine (18 to at least 144 micrograms). In order to take into account a possible tachyphylaxis, we compared PAF dose-response curves performed on one day with the curves obtained by giving the same doses separately on different days. Repeated inhalations of doubling doses of PAF caused sGaw and FEV1 to plateau after the second dose in each group, whereas methacholine provoked a dose-related decrease in sGaw and FEV1. A dose-dependent decrease in the functional indices was restored when the different doses of PAF were administered on separate days. In both groups, the fall in sGaw after inhalation of 60 micrograms as a single dose was higher than that achieved when this dose was given during a full bronchial challenge. The falls in sGaw and FEV1 after PAF inhalation were significantly higher in the asthmatics than in the normal subjects. The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). When the PD35,sGaw values were compared, PAF was found on a molar basis to be 33 fold more potent than methacholine in the normal subjects, but only fivefold more potent in the asthmatics (p < 0.05). The percentage falls in FEV1 (calculated by interpolation) for a 35% fall in sGaw, were greater in asthmatics than in normals both for methacholine (p < 0.05) and PAF (p = 0.09). Our results demonstrate a tachyphylaxis after inhalation of platelet-activating factor in normal subjects and asthmatics, and show that asthmatics develop a greater bronchial obstruction than normal subjects even if methacholine is more sensitive than platelet-activating factor at discriminating between the two groups. [less ▲]

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See detailTwo stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
Satsangi, J.; Parkes, M.; Louis, Edouard ULg et al

in Nature Genetics (1996), 14(2), 199-202

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro-intestinal disease in the Western world, with a combined prevalence of 100-200 ... [more ▼]

Crohn's disease (CD) and ulcerative colitis (UC), the chronic inflammatory bowel diseases (CIBD), are common causes of gastro-intestinal disease in the Western world, with a combined prevalence of 100-200/100,000 (ref. 1). Epidemiological studies, particularly concordance rates in twin pairs and siblings, strongly implicate genetic susceptibility in the pathogenesis of CIBD. In fact, the relative contribution of genetic factors to the pathogenesis of CD may be greater than in schizophrenia, asthma or hypertension, and at least equivalent to that in insulin-dependent diabetes. Systematic screening of the entire human genome now provides a strategy for the identification of susceptibility genes in complex polygenic disorders. We undertook a two-stage genome search for susceptibility genes in inflammatory bowel disease involving 186 affected sibling pairs from 160 nuclear families. We provide strong evidence for the presence of susceptibility loci for both CD and UC on chromosome 3, 7 and 12. We obtained the highest lod score (5.47; P = 2.66 x 10(-7) with the marker D12S83 and lod scores of 3.08 and 2.69 for D7S669 and D3S1573, respectively. Our data suggest that CD and UC are closely related, but distinct, polygenic disorders that share some, but not all, susceptibility genes. [less ▲]

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See detailFidi interpretes. La traduction orale à Rome
Rochette, Bruno ULg

in Ancient Society (1996), 27

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See detailProduction of sulfur from gypsum as an industrial byproduct
Hiligsmann, Serge ULg; Deswaef, Sophie; Taillieu, Xavier et al

in Applied Biochemistry and Biotechnology (1996), 57-8

Biological sulfate reduction was investigated at the bench and pilot scales in order to determine optimum culture conditions. Efficient strains of sulfate-reducing bacteria (SRB) were selected by ... [more ▼]

Biological sulfate reduction was investigated at the bench and pilot scales in order to determine optimum culture conditions. Efficient strains of sulfate-reducing bacteria (SRB) were selected by classical microbiological methods and by mutagenesis. Improvement factors, including stripping, scale-up, sulfate,and organic substrate concentrations, have been studied in batch bioreactors. Two types of pilot-scale bioreactors have been adopted, the first being completely mixed with free cells and the second having two stages with immobilized cells on a fixed bed. An overall bioconversion capacity of 11 kg/m(3) . d of gypsum and 1.2 kg/m(3) . d of dissolved organic carbon has been achieved in the two-stage bioreactor. [less ▲]

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See detailGuide bibliographique pour l'histoire de la principauté de Liège au 18e siècle : La vie intellectuelle
Droixhe, Daniel ULg; Vanwelkenhuyzen, Nadine ULg

in Annuaire d'Histoire Liégeoise (1996), Numéro spécial

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See detailSpontaneous complete remission and recovery of donor haemopoiesis without GVHD after relapse and apparent marrow graft rejection in poor-prognosis myelodysplastic syndrome.
Beguin, Yves ULg; Collignon, Jacques ULg; Laurent, C. et al

in British Journal of Haematology (1996), 94(3), 507-9

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a ... [more ▼]

We report a patient with poor-prognosis myelodysplastic syndrome (MDS) after successful treatment of lymphoma, who was given an allogeneic BMT, engrafted and achieved complete remission, but later had a relapse of his MDS with complete disappearance of donor haemopoiesis. After two episodes of CMV pneumonia and continued prophylactic use of ganciclovir thereafter, he experienced a spontaneous complete disappearance of all signs of MDS, including myelofibrosis, and a complete return to donor haemopoiesis. This case is the first one to suggest a graft-versus-leukaemia effect (GVL) in MDS patients. It depicts the complex relationship between GVL, graft-versus-host disease (GVHD) and graft rejection. It could also constitute a clinical illustration of the possible antileukaemic effect of CMV infection and its treatment with ganciclovir. [less ▲]

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See detailEnantioselective syntheses of no-carrier-added (nca) (S)-4-chloro-2 F-18 fluorophenylalanine and (S)-(alpha-methyl)-4-chloro-2 F-18 fluorophenylalanine
Al-Darwich, M. J.; Plenevaux, Alain ULg; Lemaire, Christian ULg et al

in Journal of Fluorine Chemistry (1996), 80(2), 117-124

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on ... [more ▼]

(S)-4-Chloro-2-fluorophenylalanine and (S)-( a-methyl)-4-chloro-2-fluorophenylalanine were synthesized and labeled with no carrier added (n.c.a.) fluorine-18 through a radiochemical synthesis relying on the highly enantioselective reaction between 4-chloro-2-[18F] fluorobenzyl iodide and the lithium enolate of (2s) -1-( tert-butyloxycarbonyl) -2-( tert-butyl)-3-methyl- 1,3-imidazolidine-4-one for (S) -4-chloro-2- [18F] fluorophenylalanine and (2S,5S)-1-( tert-butyloxycarbonyl) -2-( tert-butyl) -3,5-dimethyl- 1,3-imidazolidine-4-one for (S) -( a-methyl) -4-chloro-2- [18F] fluorophenylalanine. Quantities of about 20-25 mCi were obtained at the end of synthesis, ready for injection after hydrolysis and high performance liquid chromatography (HPLC) purification, with a radiochemical yield of 17%-20% corrected to the end of bombardment after a total synthesis time of 90-105 min from [18F] fluoride. The enantiomeric excesses were shown to be 97% or more for both molecules without chiral separation and the radiochemical and chemical purities were 98% or better. [less ▲]

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See detailA novel three-enzyme reaction cycle for the synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose
Zervosen, Astrid ULg; Elling, Lothar

in Journal of the American Chemical Society (1996), 118(8), 1836-1840

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in ... [more ▼]

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in situ regeneration of UDP galactose. We found that UDP glucose 4‘-epimerase is reductively inactivated in the presence of UMP and acceptor substrates of β-1,4-galactosyltransferase. Reactivation of UDP glucose 4‘-epimerase by the transition state analogues dUDP or dTDP 6-deoxy-d-xylo-4-hexulose in combination with the repetitive batch technique enabled us to use the native enzymes for 11 days in this cycle. With 10 U of sucrose synthase, 5 U of UDP glucose 4‘-epimerase, and 1.25 U of β-1,4-galactosyltransferase, 594 mg of LacNAc could be synthesized. N-Acetyllactosamine was also subsequently converted to Neu5Acα2,6Galβl,4GlcNAc with α-2,6-sialyltransferase and CMP-Neu5Ac. [less ▲]

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See detailVers une perspective transactionnelle du stress au travail : pistes d'évaluations méthodologiques
De Keyser, Véronique ULg; Hansez, Isabelle ULg

in Cahiers de Médecine du Travail (1996), 33(3), 133-144

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle ... [more ▼]

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle de la situation et adopte une conception transactionnelle du stress psychologique au travail insistant sur l'importance de l'évaluation de la situation par l'individu et les processus de coping, dans une perspective diachronique (Mackay et Cooper, 1987). Cet article synthétise les indices utilisés généralement dans les recherches sur le stress au travail et discute leurs limites. Les problèmes méthodologiques envisagés sont les suivants: la difficulté d'établir des relations causales, les problèmes de validité discriminante et convergente, la mise en évidence des effets de chronicité, la fidélité des mesures. Des suggestions sont alors proposées, basées principalement sur une démarche combinant comparaisons intra et inter-individuelles, la méthode des «critical job events» ou approche épidémiologique, les stratégies de triangulation, le tout dans une perspective longitudinale. Pour terminer, des exemples en milieu hospitalier illustrent les démarches proposées. [less ▲]

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See detailDNA bending by the silencer protein NeP1 is modulated by TR and RXR.
Arnold, R.; Burcin, M.; Kaiser, Bruno ULg et al

in Nucleic Acids Research (1996), 24(14), 2640-7

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing ... [more ▼]

NeP1 binds to the F1 silencer element of the chicken lysozyme gene and, in the presence of TR, v-ERBA or RAR, synergistically represses transcriptional activity. This repression involves a silencing mechanism acting independently of the relative promoter position. Here we show that NeP1 alone can induce a significant directed bend on DNA. The chicken homologue of human NeP1, CTCF, shows identical binding and bending properties. In contrast, the isolated DNA binding domain of CTCF efficiently binds DNA, but fails to confer bending. Similarly, the TR-RXR hetero- or homodimer, binding adjacent to NeP1 at the F2 sequence, do not show significant DNA bending. The binding of the T3 ligand to TR changes neither the magnitude nor the direction of the NeP1 induced bend. However, when all factors are bound simultaneously as a quaternary complex, the TR-RXR heterodimer changes the location of the bend center, the flexure angle and the bending direction. [less ▲]

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See detailPit-1 polymorphism and milk production parameters in Italian Holstein-Friesian bulls.
Renaville, Robert ULg; Vrech, E.; Gengler, Nicolas ULg et al

in Journal of Animal Science (1996), 74(1), 111

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See detailDéveloppement actuel du concept de l'hygiène en agro-alimentaire et des exigences des normes européennes.
Vindevogel, Henri ULg; Daube, Georges ULg; Hans, J. C. et al

in Annales de Médecine Vétérinaire (1996), 140

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See detailImprint and Brush Cytology in the Diagnosis of Canine Intranasal Tumours
Clercx, Cécile ULg; Wallon, J.; Gilbert, S. et al

in Journal of Small Animal Practice (1996), 37(9), 423-7

Fifty-four dogs with nasal tumours were included in this study. Based on histopathology 52 tumours were malignant (36 epithelial and 16 mesenchymal) and two were benign (one oncocytoma and one ... [more ▼]

Fifty-four dogs with nasal tumours were included in this study. Based on histopathology 52 tumours were malignant (36 epithelial and 16 mesenchymal) and two were benign (one oncocytoma and one pleiomorphic adenoma). Malignancy was significantly more frequently diagnosed by imprint cytology (81 per cent of the cases) than by brush cytology (56 per cent). Brush cytology was a significantly more sensitive technique in epithelial than in mesenchymal tumours, while the sensitivity of imprint cytology was not affected by the histological type. Brush cytology determined an epithelial origin in 88 per cent of epithelial tumours, and imprint cytology in 90 per cent. In mesenchymal tumours, the scores were significantly lower, the histological type being determined in only 20 per cent and 50 per cent, using brush and imprint cytology, respectively. [less ▲]

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See detailRheinische Wortgeographie. Karten des Rheinischen Wörterbuchs und ihre computative Auswertung. Teil I
Lausberg, Helmut; Möller, Robert ULg

in Rheinische Vierteljahrsblätter (1996), 60

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See detailPseudoaneurisma gigante del ventriculo izquierdo
Olivieri, E.; Guessaghi, R.; Chavin, A. et al

in Prensa Medica Argentina (1996), 83(10), 919-924

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His ... [more ▼]

A 85 years old patient was hospitalized because of thoracic pain, lasting since three months. He suffered of Parkinson's disease and he was a smoker. The pain increased with cough and Vansalva's test. His left arm was cianotic. An arterial obstruction was suspected. Dopler ultrasound of the left arm confirmed a partial obstruction of the left axillar artery. Surprisingly, thoracic scan and MRI found an important cardiomegaly. The heart was in contact with the diaphragmatic and gastric region. Ecocardiography confirmed a 7 cm pseudo aneurysm of the left ventricle. Coronarography showed extreme hypokinesia of the left ventricle. There was also an obstruction of the right coronary and 50 % stenosis of the left coronary. Pseudo aneurysm was a complication of myocardial infarction of the left ventricle. Surgery was offered to the patient, but he declined the intervention. He was dismissed with medical treatment and anticoagulation. The patient deceased three months later. [less ▲]

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See detailLe vétérinaire et la qualité microbiologique des denrées alimentaires d’origine animale
Vindevogel, Henri ULg; Daube, Georges ULg; Denys, Jacques et al

in Annales de Médecine Vétérinaire (1996), 141

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See detailModelling of multiphase flow in packed beds by computer-assisted x-ray tomography
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Measurement Science & Technology (1996), 7(3), 436-443

The high resolution which can be obtained by computer-assisted x-ray tomography is used to investigate Various scale heterogeneities of the flow texture characterizing multiphase flow in packed beds. The ... [more ▼]

The high resolution which can be obtained by computer-assisted x-ray tomography is used to investigate Various scale heterogeneities of the flow texture characterizing multiphase flow in packed beds. The direct counting of 'irrigated' pixels allows the determination of the number of individual liquid rivulets as well as their size. The evolution of the liquid flow texture versus the liquid velocity agrees quite well with the predictions of a percolation-based model. This agreement is further confirmed by the comparison of the experimental hold-up values averaged over the column cross-section with the theoretical model. [less ▲]

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See detailForbidden Lines in 6pk (j=1-5) configurations
Biémont, Emile ULg; Quinet, Pascal ULg

in Physica Scripta (1996), 54

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See detailBequest motives and the level and composition of wealth in Belgium. A survey based analysis
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Cahiers Economiques de Bruxelles (1996), (149), 31-53

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See detailLes adénomes gonadotropes
Beckers, Albert ULg; Stevenaert, Achille ULg

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1996), 37(4-5), 299-305

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait ... [more ▼]

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait gonadotropes. Étant donné l'absente de symptomatologie spécifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant déjà entraîné un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de sécrétion ou encore par méthodes d'immunohistochimie ou encore par la détection de l'ARN messager correspondant aux sous-unités hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphénoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces. [less ▲]

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See detailOn the residual advection of passive constituents
Delhez, Eric ULg

in Journal of Marine Systems (1996), 8(3-4), 147-169

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct ... [more ▼]

In this paper, the different approaches used to simulate the long-term advection of passive constituents on tidal shelves are discussed in the framework of large scale hydrodynamic modelling. The direct approach in which the unsteady mesoscale (tides and storm surges) and macroscale (monthly or seasonal mean processes) currents are used is very demanding in computer resources (CPU and memory). On the other hand, the use of residual velocities gives a larger understanding of the long-term transport processes and simplifies numerical treatments. However, the definition of such appropriate velocities is still an open question. In the context of large scale models, Lagrangian residuals are not applicable. Eulerian residual transport velocities fail to represent long-term motions when tidal non-linearities are important. The first order Lagrangian residual velocity introduced by Feng et al. (1986a) and generalized here is shown to be a very good solution. The North-Western European Continental Shelf (NWECS) is used as an example to compare the numerical solutions obtained with the different approaches. [less ▲]

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See detailThiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain
Bettendorff, Lucien ULg; Mastrogiacomo, Frank; Kish, Stephen J et al

in Journal of Neurochemistry (1996), 66(1), 250-8

Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two- to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine ... [more ▼]

Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two- to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine content between biopsied and autopsied human brain, except that in the latter, thiamine triphosphate was undetectable. The main thiamine phosphate-metabolizing enzymes could be detected in autopsied brain, and the kinetic parameters were comparable to those reported in other species. Thiamine diphosphate levels were lowest in hippocampus (15 +/- 4 pmol/mg of protein) and highest in mammillary bodies (24 +/- 4 pmol/mg of protein). Maximal levels of thiamine and its phosphate ester were found to be present at birth. In parietal cortex and globus pallidus, mean levels of total thiamine in the oldest age group (77-103 years) were, respectively, 21 and 26% lower than those in the middle age group (40-55 years). Unlike cerebral cortex, the globus pallidus showed a sharp drop in thiamine diphosphate levels during infancy, with concentrations in the oldest group being only approximately 50% of the levels present during the first 4 months of life. These data, consistent with previous observations conducted in blood, suggest a tendency toward decreased thiamine status in older people. [less ▲]

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See detailDe wildste bloei van overgave en genade. Over Gezelle en Van Ostaijen
Spinoy, Erik ULg

in Gezelliana (1996), 8(1), 1-42

This article reflects on the importance of the 19th century romantic poet Guido Gezelle for the expressionist Paul van Ostaijen, who repeatedly stressed the pioneering character of this poetic oeuvre and ... [more ▼]

This article reflects on the importance of the 19th century romantic poet Guido Gezelle for the expressionist Paul van Ostaijen, who repeatedly stressed the pioneering character of this poetic oeuvre and the influence it had on his own work. [less ▲]

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See detailCombined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates
Zervosen, Astrid ULg; Stein, Andreas; Adrian, Holger et al

in Tetrahedron (1996), 52(7), 2395-2404

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside ... [more ▼]

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside monophosphates la-d by different kinases A. Further combination with recombinant dTDP-glucose 4,6-dehydratase D enabled us to synthesize dUDP-6-deoxy-alpha-D-xylo-4-hexulose 5 from ld on a preparative scale. By using the repetitive batch technique the enzymatic syntheses of nucleotide (deoxy) sugars 3a-d, 5 could be realized on a 0.1 - 0.5 g scale. [less ▲]

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See detailWound repair-induced expression of a stromelysins is associated with the acquisition of a mesenchymal phenotype in human respiratory epithelial cells
Buisson, A. C.; Gilles, Christine ULg; Polette, M. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1996), 74(3), 658-69

Wound repair involves many processes including cell migration, provisional matrix deposition, and remodeling. All of these processes are likely to be affected by matrix-modifying enzymes. Members of the ... [more ▼]

Wound repair involves many processes including cell migration, provisional matrix deposition, and remodeling. All of these processes are likely to be affected by matrix-modifying enzymes. Members of the matrix metalloproteinases family are physiologic mediators of the extracellular matrix degradation. Within this matrix metalloproteinases family, stromelysins can degrade many components of the extracellular matrix. We therefore tested the hypothesis that stromelysins could be produced by human surface respiratory epithelial (HSRE) cells repairing a wound. Experimental wounds were created in vitro in HSRE cell cultures and in situ in human bronchial mucosa maintained in organ culture. Stromelysin production was measured by casein-gel zymography in cellular protein extracts derived from repairing migratory and nonrepairing stationary cells of wounded HSRE cell cultures. Stromelysin-producing cells present in cell and tissue cultures were localized and characterized using immunofluorescence techniques. Zymographic and immunofluorescence techniques showed that stromelysins were produced exclusively by the migratory HSRE cells. Zymogram analysis showed that stromelysins were overexpressed and overactivated during the wound repair process, with the maximal production observed at wound closure. Using an anti-cytokeratin 14 antibody, we identified stromelysin-3-producing cells as basal epithelial cells. Moreover, most stromelysin-3-producing cells expressed the mesenchymal marker vimentin. Similar to stromelysins localization, vimentin-positive HSRE cells were exclusively located in the wounded area, and they were also positive to cytokeratin 14. In conclusion, stromelysins are suggested to be involved in HSRE cell migration and extracellular matrix remodeling during wound repair. Furthermore, stromelysin production by repairing HSRE cells is linked to the acquisition of a mesenchymal phenotype. HSRE cell migration may then be associated with the shift from an epithelial to a mesenchymal phenotype. [less ▲]

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See detailAssureurs et prédations: Les développements de l'assurance contre le vol en France
Lemaître, André ULg

in Les Cahiers de la Sécurité Intérieure (1996), N°25

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See detailDe modernist en de massacultuur: Van Ostaijens ‘Huldegedicht aan Singer’
Spinoy, Erik ULg

in Filosofie Magazine (1996), 5(3), 29

This article re-reads the famous poem 'Huldegedicht aan Singer' in view of Van Ostaijen's increasingly critical attitude towards the emerging consumer society of the 1920s.

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