References of "Article"
     in
Bookmark and Share    
Peer Reviewed
See detailDENSITY-POLARIZATION FUNCTIONAL THEORY OF THE RESPONSE OF A PERIODIC INSULATING SOLID TO AN ELECTRIC-FIELD
GONZE, X.; Ghosez, Philippe ULg; GODBY, R. W.

in Physical Review Letters (1995), 74(20), 4035-4038

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailNumber and relative size of thenar motor units estimated by an adapted multiple point stimulation method.
Wang, François-Charles ULg; Delwaide, Paul ULg

in Muscle & nerve (1995), 18(9), 969-79

An adapted multiple point stimulation (AMPS) method is described for estimating the number and relative size of thenar motor units. With this method, the median nerve was stimulated at various sites from ... [more ▼]

An adapted multiple point stimulation (AMPS) method is described for estimating the number and relative size of thenar motor units. With this method, the median nerve was stimulated at various sites from the wrist to the elbow. To avoid alternation, only two or three clearly identifiable surface-recorded motor unit action potentials (S-MUAPs) were recruited at each point by incremental stimulation. A total of 10 S-MUAPs, elicited from four to five distinct stimulation points, was used to calculate the average S-MUAP size. By dividing the maximum M-potential size by that value, a motor unit number estimate (MUNE) was derived. In 59 healthy volunteers, from 19 to 87 years old, the mean average S-MUAP size was 87 +/- 27.6 microV.ms and the mean MUNE was 278 +/- 113 motor units. When performed repeatedly, the results were reproducible. The number of motor units declined exponentially with age while average S-MUAP sizes increased only moderately. To assess the validity of the AMPS method, its results were correlated with those obtained using the F-response technique. The correlation coefficient was 0.83 (P < 0.001). [less ▲]

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailAmylin/islet amyloid polypeptide: biochemistry, physiology, patho-physiology.
Castillo, M. J.; Scheen, André ULg; Lefebvre, Pierre ULg

in Diabète & Métabolisme (1995), 21(1), 3-25

Amylin is a 37 amino-acid peptide mainly produced by the islet beta-cell. Aggregation of amylin is partly responsible for amyloid formation. Amyloid deposits occur both extracellularly and intracellularly ... [more ▼]

Amylin is a 37 amino-acid peptide mainly produced by the islet beta-cell. Aggregation of amylin is partly responsible for amyloid formation. Amyloid deposits occur both extracellularly and intracellularly and may contribute to beta-cell degeneration. Amylin is packed in beta-cell granules and cosecreted with insulin in response to the same stimuli but, unlike other beta-cell products, it is produced from specific a gene on chromosome 12. Basal, plasma amylin concentrations are around 5 pM, and increase fourfold after meals or glucose. Higher levels are found in cases of insulin resistance, obesity, gestational diabetes and in some patients with NIDDM. Low or absent levels are found in insulin-dependent diabetic patients. There are similarities between amylin and non beta-cell peptides such as calcitonin gene related peptides (CGRP). They may bind to the same receptor, determine similar post-receptor phenomena and qualitatively similar actions but with different degree of potency. The actions of amylin are multiple and mostly exerted in the regulation of fuel metabolism. In muscle, amylin opposes glycogen synthesis, activates glycogenolysis and glycolysis (increasing lactate production). Consequently, amylin increases lactate output by muscle and increases the plasma lactate concentration. In fasting conditions, this lactate may serve as a gluconeogenic substrate for the liver, contributing to replenish depleted glycogen stores and to increase glucose production. In non-fasting conditions, lactate can be transformed by liver in triglycerides. It is not clear at present whether amylin actions on the liver are direct or mediated by changes in circulating metabolites. A probably indirect effect of amylin in muscle is to decrease insulin- (or glucose)-induced glucose uptake, which may contribute to insulin resistance. Other actions include inhibition of glucose-stimulated insulin secretion and, in general, actions mimicking CGRP effects. Some of these actions are seen at supraphysiological concentrations. The physiopathological consequences of amylin deficiency, or excess are under active by investigated. [less ▲]

Detailed reference viewed: 38 (1 ULg)
Peer Reviewed
See detailL'hyperthyroïdie sévère associée à la prise d'amodarone: une urgence chirurgicale
Meurisse, Michel ULg; Hamoir, Etienne ULg; Joris, Jean ULg et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1995), 36(1), 35-45

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du ... [more ▼]

L'évolution de certaines thyréotoxicoses associées à la prise d'amiodarone peut être particulièrement grave et rapide, menaçant le pronostic vital. De déclenchement brutal, sans relation avec la durée du traitement par amiodarone, elles peuvent survenir aussi bien chez des sujets porteurs de thyroïdopathies méconnues ou négligées au moment de l'induction du traitement, que chez des patients apparemment indemnes de toute pathologie thyroïdienne pré-existante. Le traitement médical conservateur est le plus souvent inefficace. Dans ces cas, il convient de poser sans hésitation, l'indication d'une thyroïdectomie la plus radicale possible. Ce rapport traite de l'évolution post-opératoire spectaculaire et favorable de 13 cas consécutifs de thyréotoxicose sévère associée à la prise d'amiodarone. La validité de l'approche chirurgicale repose sur la correction rapide et définitive de l'état toxique après exérèse glandulaire. La morbidité quasi nulle liée au geste chirurgical est la seule alternative thérapeutique antithyroïdienne existante qui permette de poursuivre un traitement par amiodarone lorsque celui-ci est indiqué pour contrôler une arytmie menaçante [less ▲]

Detailed reference viewed: 87 (7 ULg)
Peer Reviewed
See detailSimulation of Square Cup Deep Drawing with Different Finite Elements
Kaiping, Li; Habraken, Anne ULg; Bruneel, H.

in Journal of Materials Processing Technology (1995), 50(1-4), 81-91

Detailed reference viewed: 25 (5 ULg)
Peer Reviewed
See detailThe effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
Tfelt-Hansen, P.; Henry, P.; Mulder, L. J. et al

in Lancet (1995), 346(8980), 923-6

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg ... [more ▼]

Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailLes fondements de l'analyse numérique de photos prises au fisheye pour des besoins topoclimatologiques
Cornélis, Bernard ULg; Erpicum, Michel ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

Fisheye pictures are frequently used in forestry and in ecology for canopy measurements. In climatology, it seems that they have only been used for illustration purposes. In fact, fisheye pictures are ... [more ▼]

Fisheye pictures are frequently used in forestry and in ecology for canopy measurements. In climatology, it seems that they have only been used for illustration purposes. In fact, fisheye pictures are rich in climatological information. Digital fisheye image processing can be used for applied climatology as well as for topoclimatological studies. It allows the quantification of insolation, diffuse radiation, sky-view factor,.… In other words, it provides an objective assessment of the exposure of a site or of a measuring device. This article introduces the basis for digital fisheye image processing. The possibilities offered by this tool will be illustrated with sunshine measurements in an urban environment. [less ▲]

Detailed reference viewed: 95 (24 ULg)
See detailRemote Sensing and Urban Change
Donnay, Jean-Paul ULg; Barnsley, Mike

in GISDATA Newsletter (1995), 6

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailPharma clinics. Comment je traite ... une anemie (3e partie).
Beguin, Yves ULg

in Revue Médicale de Liège (1995), 50(12), 497-8

Detailed reference viewed: 29 (6 ULg)
Full Text
Peer Reviewed
See detailGlucose inhibits human placental GH secretion, in vitro
Patel, N.; Alsat, E.; Igout, Ahmed ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(5), 1743-6

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation ... [more ▼]

Human placenta specifically expresses the GH-V gene leading to the production of placental Growth Hormone (PGH). During pregnancy, PGH levels increase progressively in maternal blood, but its regulation remains unknown. In this study the effect of glucose on PGH secretion by human term placenta was tested, in vitro, by means of two different experimental models: organ culture of villous tissue and primary culture of isolated cytotrophoblasts. PGH was assayed in the culture medium by an immunoradiometric assay using a specific PGH monoclonal antibody. The presence of glucose (25 mmol/L) in the culture medium significantly inhibited (p < 0.001) the secretion of PGH by either placental villous explants or by cultured trophoblast cells. This inhibitory effect of glucose on PGH secretion was dose-dependent. More than 50% inhibition being observed with 5.5 mmol/L. In the same conditions, the daily production of hPL and hCG, were unmodified. Furthermore, the glucose-induced inhibition of PGH secretion was more effective when cultured trophoblast cells are differentiated into syncytiotrophoblast. This study demonstrates, for the first time, that among the gestational polypeptide hormones secreted by the human placenta, only PGH secretion is modulated by glucose, suggesting a key metabolic role for this hormone during pregnancy. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Peer Reviewed
See detailExogenous glucose oxidation during exercise in relation to the power output.
Pirnay, Freddy ULg; Scheen, André ULg; Gautier, J. F. et al

in International Journal of Sports Medicine (1995), 16(7), 456-60

In order to study the influence of the power output on the oxidation rate of exogenous glucose and on the contribution of the various substrates to the energy demand, we combined the use of artificially ... [more ▼]

In order to study the influence of the power output on the oxidation rate of exogenous glucose and on the contribution of the various substrates to the energy demand, we combined the use of artificially enriched 13C-glucose with classical indirect calorimetry during uphill treadmill exercise. Six young male healthy subjects underwent three exercise bouts, in a randomized order and at least two weeks apart, at a low (45% VO2max, 1822 +/- 194 ml O2/min for 4 hours), moderate (60% VO2max, 2582 +/- 226 ml O2/min for 3 hours), and high intensity (75% VO2max, 3036 +/- 287 ml O2/min for 2 hours). After 10 min of exercise, each subject ingested 100 g of artificially 13C-labelled glucose dissolved in 400 ml of water. Over the four hours of the exercise at 45% VO2max, the amount of exogenous glucose oxidized was 89.5 +/- 5.9 g from the 100 g ingested. In all exercise bouts, the oxidation of exogenous glucose already began during the first 30 min after ingestion and peaked at 120 min. The maximum oxidation rates averaged 0.64 +/- 0.07, 0.75 +/- 0.04, and 0.63 +/- 0.08 g/min, and the mean amounts of exogenous glucose oxidized over the first two hours averaged 51.7 +/- 8.0, 61.5 +/- 6.6 and 50.9 +/- 8.45 g, at 45, 60 and 75% VO2max respectively. The contribution of the oxidation of exogenous glucose to the total energy supply progressively decreased when the power output increased, from 19.6 to 12.2%. In the meantime, the contribution of total carbohydrates (exogenous+endogenous) progressively increased from 55.1 to 77.8% while the contribution of lipids decreased from 35.5 to 16.6%. In conclusion, exogenous glucose ingested during exercise is largely oxidized and strongly contributes to the energy supply. The oxidation rate first increases with the power output, but levels off or even decreases at high intensity exercise. [less ▲]

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detailReaction Window in the single-electron capture by Ammonia Dications.
Leyh, Bernard ULg; Hoxha, Antuan

in Chemical Physics (1995), 192

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC ... [more ▼]

Single-electron capture (SEC) by (NH3)2+ with rare gases (He, Ne, Ar, Kr, Xe) and benzene, (NH3)2++G->NH3++G+, has been investigated using a forward geometry double-focussing mass spectrometer. The SEC cross-section goes through a maximum within a reaction window centered at an exothermicity of approximately 4.5 eV. This corresponds to a target-projectile distance for the charge transfer of about 3.2 Angstöm. The average internal energy of NH3+-ions resulting from SEC has been obtained both via translational energy gain measurements and via an analysis of the daughter ion spectra. The agreement between both methods is satisfactory and shows that the lower the ionisation energy of the target, the more probable the excitation of NH3+ to the A2E state. With benzene (ionization energy=9.25 eV) as the target gas, however, the excess energy is converted partly to internal energy of C6H6+, leading most probably to the D2B2u, E2B1u and F2A1g states of C6H6+. A model based on the Landau-Zener non-adiabatic formalism, including one entrance channel (NH32++G) and two exit channels (NH3+ X2A"2+G+ and NH3+ A2E+G+) accounts qualitatively for the observed results in the case of exothermic single-electron capture. This model is not appropriate for slightly exothermic and endothermic charge transfer, i.e., in the present case, for the Ne and He target gases. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailFlux de nitrate dans une zone à nappes superficielles en Wallonie (Belgique)
Demarets, X.; Marcoen, Jean Marie ULg; Agneessens, R. et al

in Cahiers Agricultures (1995), 4

Detailed reference viewed: 23 (5 ULg)
Full Text
Peer Reviewed
See detailTransgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery.
Plumier, Jean-Christophe ULg; Ross, B.; Currie, R. W. et al

in Journal of Clinical Investigation (1995), 95(4), 1854-60

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock ... [more ▼]

Heat shock treatment induces expression of several heat shock proteins and subsequent post-ischemic myocardial protection. Correlations exist between the degree of stress used to induce the heat shock proteins, the amount of the inducible heat shock protein 70 (HSP70) and the level of myocardial protection. The inducible HSP70 has also been shown to be protective in transfected myogenic cells. Here we examined the role of human inducible HSP70 in transgenic mouse hearts. Overexpression of the human HSP70 does not appear to affect normal protein synthesis or the stress response in transgenic mice compared with nontransgenic mice. After 30 min of ischemia, upon reperfusion, transgenic hearts versus nontransgenic hearts showed significantly improved recovery of contractile force (0.35 +/- 0.08 versus 0.16 +/- 0.05 g, respectively, P < 0.05), rate of contraction, and rate of relaxation. Creatine kinase, an indicator of cellular injury, was released at a high level (67.7 +/- 23.0 U/ml) upon reperfusion from nontransgenic hearts, but not transgenic hearts (1.6 +/- 0.8 U/ml). We conclude that high level constitutive expression of the human inducible HSP70 plays a direct role in the protection of the myocardium from ischemia and reperfusion injury. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailThe Dissociaitve Ionization of C2H2 and C2D2. The [CH(CD)]+ dissociaiton channel. The H(D)C-C(D)H Binding Energy.
Davister, M.; Locht, Robert ULg

in Chemical Physics (1995), 191

The dissociative electroionization of C2H2(C2D2) has been investigated in the CH+(CD+) dissociation channel. The translational energy distribution of the fragment ion has been examined as a function of ... [more ▼]

The dissociative electroionization of C2H2(C2D2) has been investigated in the CH+(CD+) dissociation channel. The translational energy distribution of the fragment ion has been examined as a function of the electron energy between 20 and 99 eV. The first differentiated ionization efficiency curve has been measured for KE(CH+)=0.0-6.0 eV. Threshold energies of CH+ and CD+ have been measured and the effect of isotopic substitution is discussed. For the lowest onset of both CH+ and CD+, and from the kinetic energy measurements, the C-C bond strength has been derived, i.e. D(HC-CH)=9.83+/-0.10 eV. Higher appearance energies are assigned and reaction mechanisms are proposed. Above 34 eV electron energy, the CH+ ions carrying 2.0-5.5 eV kinetic energy are produced through Coulomb explosion of (C2H2)2+ states. [less ▲]

Detailed reference viewed: 30 (0 ULg)
Peer Reviewed
See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Full Text
Peer Reviewed
See detailLow-dose methotrexate: an effective corticosteroid-sparing agent in the musculoskeletal manifestations of sarcoidosis
Kaye, O.; Palazzo, E.; Grossin, M. et al

in British Journal of Rheumatology (1995), 34(7), 642-644

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and ... [more ▼]

Extrapulmonary sarcoidosis, and particularly the presence of musculoskeletal complications of the disease, may require chronic corticosteroid therapy. In five patients with biopsy-proven sarcoidosis and presenting recalcitrant forms of the disease, we introduced low-dose oral methotrexate (MTX) [10 mg/week (7.5-15)] for 30 months (16-34) to control the clinical and biological symptoms as well as to try to reduce the intolerated steroid posology. Beneficial effects were observed within 8-12 weeks in all patients, which allowed a reduction of 59% (35-75) of the corticosteroid posology, and maintained with a follow-up of 3 yr in 4/5 patients. No significant toxicity was observed. MTX appears to be an efficient, safe and corticosteroid-sparing therapeutic agent for the treatment of recalcitrant musculoskeletal manifestations of sarcoidosis. [less ▲]

Detailed reference viewed: 4 (0 ULg)
Full Text
Peer Reviewed
See detailLa disparition de l'absorption
Kefer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1995)

Detailed reference viewed: 10 (7 ULg)
Full Text
See detailEffectiveness of a video training programme used to improve error identification and feedback processes by physical education student teachers
Cloes, Marc ULg; Premuzak, Jean

in International Journal of Physical Education (1995), 32(3), 4-10

Detailed reference viewed: 120 (5 ULg)
Full Text
Peer Reviewed
See detailPET radiopharmaceuticals in Europe : Current use and data relevant for the formulation of summaries of product characteristics (SPCs)
Meyer, G. J.; Waters, S. L.; Coenen, H. H. et al

in European Journal of Nuclear Medicine (1995), 22(12), 1420-1432

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task ... [more ▼]

The increasing use of radiopharmaceuticals for positron emission tomography (PET) has come to the attention of regulatory bodies. In order to help authorities in all aspects, the EANM has formed a task group for licensing PET radiopharmaceuticals; this group has surveyed the use of these compounds in Europe by a questionnaire. The number of PET centres that responded to the questionnaire was 26, which included more than 90% of the larger European PET centres. The survey showed that 2-[18F]fluoro-2-deoxyglucose is by far the most important PET radiopharmaceutical with more than 200 applications per week, followed by [15O]water, [15O]carbonmonoxide, [13N]ammonia, [11C]-l-methionine, andl-6-[18F]fluoro-DOPA. More than 25 other PET radiopharmaceuticals are in regular use, however, at rather low application frequencies. The data were used by the European Pharmacopoeia Commission for its priority rating for requesting the formulation of monographs. Since it is likely that group registrations will be issued by authorities for the PET radiopharmaceuticals, relevant data on toxicity and dosimetry for the formulation of summaries of product characteristics have been collected by the task group as well. [less ▲]

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailNucleotide sequence of the ovine P53 tumor-suppressor cDNA and its genomic organization.
Dequiedt, Franck ULg; Kettmann, Richard ULg; Burny, A. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 5(4),

Detailed reference viewed: 22 (7 ULg)
Peer Reviewed
See detailR-HuEPO hyporesponsiveness - who and why ?
Danielson, B.; Beguin, Yves ULg; Bommer, J. et al

in Nephrology Dialysis Transplantation (1995), 10

Detailed reference viewed: 8 (2 ULg)
Peer Reviewed
See detailPlasma progesterone and IGF-I levels at puberty in Italian Simmental and Friesian heifers with various genetic merit.
Prandi, A.; Rossi, C.; Tondolo, A. et al

in Journal of Animal Science (1995), 73(Suppl 1), 222

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailEffect of previous antidepressant therapy on the growth hormone response to apomorphine.
Pitchot, William ULg; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in Neuropsychobiology (1995), 32(1), 19-22

Several lines of evidence suggest a role for dopamine in the pathophysiology of depression. In 1988, we reported a blunted response of growth hormone (GH) to apomorphine, a dopaminergic agonist, in ... [more ▼]

Several lines of evidence suggest a role for dopamine in the pathophysiology of depression. In 1988, we reported a blunted response of growth hormone (GH) to apomorphine, a dopaminergic agonist, in endogenous depression. However, an antidepressant washout period is a major confounding factor in studies assessing the GH response to apomorphine. Indeed, whereas the influence of tricyclic antidepressants on the GH response to apomorphine is presently unknown, several reports have suggested that tricyclics may impair the GH response to clonidine for periods longer than 3 weeks following their discontinuation. In the present study, we hypothesized that a blunted GH response to apomorphine in depressed patients could be related to the recent administration of antidepressants. Therefore, the GH response to apomorphine (0.5 mg) was studied in 11 male DSM-III-R major depressive inpatients who had never received antidepressant therapy (group 1) compared to 11 normal controls and 11 major depressive inpatients drug free for at least 2 weeks (group 2). The three groups differed significantly in the GH peak response to apomorphine: mean (SD) 5.4 (4.0) ng/ml in group 1, 25.5 (10.7) in normal controls, and 5.5 (5.1) in group 2 (F = 15.5, df = 3, 30, p = 0.00001). While group 1 and normal controls (F = 21.8, p = 0.0002) as well as group 2 and controls (F = 5.6, p = 0.03) differed significantly, group 1 and group 2 did not (F = 0.18, p = 0.68). These results suggest that a washout period of 2 weeks could be sufficient in studies assessing the GH response to apomorphine. [less ▲]

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailSituation actuelle de la loutre, Lutra lutra, en Belgique et problématique de sa conservation
Libois, Roland ULg; Hallet, Catherine

in Cahiers d'Ethologie (1995), 15(2-3-4), 157-168

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few ... [more ▼]

Widespread all over the country till the end of the last century, the otter has rapidly declined. In 1973 when hunting was definitely closed, the otter was already threatened and restricted to a few localities. In 1889, the Belgian Ministry of agriculture decided to pay bounties for otters, a system which was cancelled only in 1963. Game statistics of the past century allow the annual otter bag to evaluated as roughly 25 % of the standing population. As it is the case in other European industrialised countries, freshwater habitat loss and water pollution lead to a considerable decrease of the river carrying capacity. Almost all the rivers flowing in the Northern part of Belgium are now lifeless or at least in a very bad condition. South of the river Meuse, some accidental pollutions are regularly reported (chloring in the river Ourthe in 1993; chloracetic acid in the Sûre in 1990...) and the level of organic pollution rises from year to year. Moreover, the tourism (angling, camp sites, kayak) nare more and more intensive leading to major disturbances, particularly during the summer months. Finally, the Ministery of equipment is developing a policy of big hydraulic works (dams, embankments, dredging...) along the river Ourthe, one of the last to be occupied by a few otters. [less ▲]

Detailed reference viewed: 48 (4 ULg)
Full Text
Peer Reviewed
See detailBage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Lymphocytes
Boel, P.; Wildmann, C.; Sensi, Ml. et al

in Immunity (1995), 2(2), 167-75

Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues ... [more ▼]

Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL) on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3, which are not expressed in normal tissues except in testis. Here, we report the identification of a new gene that codes for another of these antigens. This gene, named BAGE, codes for a putative protein of 43 aa and seems to belong to a family of several genes. The antigen recognized by the autologous CTL consists of BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw 1601 molecule. Gene BAGE is expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal tissues with the exception of testis. Because of its tumor-specific expression, the BAGE-encoded antigen may prove useful for cancer immunotherapy. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailLate Lower and Middle Devonian Miospores from Saudi Arabia.
Loboziak, S; Streel, Maurice ULg

in Review of Palaeobotany and Palynology (1995), 89

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailHyperfine structure of infrared vanadium lines
Palmeri, P.; Biémont, Emile ULg; Aboussaïd, A. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1995), 28

Detailed reference viewed: 6 (3 ULg)
Peer Reviewed
See detailKozani-Grevena Earthquake and the Active tectonics of Northern Greece
Meyer, B.; Armijo, R.; Hubert, Aurelia ULg et al

Scientific journal (1995)

Detailed reference viewed: 4 (1 ULg)
Peer Reviewed
See detailComparison and validation of heat stress indices in experimental studies
Mairiaux, Philippe ULg; Malchaire, Jacques

in Ergonomics (1995), 38(1), 58-72

Detailed reference viewed: 17 (1 ULg)
Peer Reviewed
See detailAntihyperglycaemic agents. Drug interactions of clinical importance.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (1995), 12(1), 32-45

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias ... [more ▼]

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias, coronary insufficiency, heart failure and arthropathies. Thus, polymedication is the rule in this population, and the risk of drug interactions is important, particularly in elderly patients. The present review is restricted to the interactions of other drugs with antihyperglycaemic compounds, and will not consider the mirror image, i.e. the interactions of antihyperglycaemic agents with other drugs. Oral antihyperglycaemic agents include sulphonylureas, biguanides--essentially metformin since the withdrawn of phenformin and buformin--and alpha-glucosidase inhibitors, acarbose being the only representative on the market. These drugs can be used alone or in combination to obtain better metabolic control, sometimes with insulin. Drug interactions with antihyperglycaemic agents can be divided into pharmacokinetic and pharmacodynamic interactions. Most pharmacokinetic studies concern sulphonylureas, whose action may be enhanced by numerous other drugs, thus increasing the risk of hypoglycaemia. Such an effect may result essentially from protein binding displacement, inhibition of hepatic metabolism and reduction of renal clearance. Reduction of the hypoglycaemic activity of sulphonylureas due to pharmacokinetic interactions with other drugs appears to be much less frequent. Drug interactions leading to an increase in plasma metformin concentrations, mainly by reducing the renal excretion or the hepatic metabolism of the biguanide, should be avoided to limit the risk of hyperlactaemia. Owing to its mode of action, pharmacokinetic interferences with acarbose are limited to the gastrointestinal tract, but have not been extensively studied yet. Pharmacodynamic interactions are quite numerous and may result in a potentiation of the hypoglycaemic action or, conversely, in a deterioration of blood glucose control. Such interactions may be observed whatever the type of antidiabetic treatment. They result from the intrinsic properties of the coprescribed drug on insulin secretion and action, or on a key step of carbohydrate metabolism. Finally, a combination of 2 to 3 antihyperglycaemic agents is common for treating patients with NIDDM to benefit from the synergistic effect of compounds acting on different sites of carbohydrate metabolism. Possible pharmacokinetic interactions between alpha-glucosidase inhibitors and classical antidiabetic oral agents should be better studied in the diabetic population. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Peer Reviewed
See detailVarious persistency measures and relationships with total, partial and peak milk yields
Gengler, Nicolas ULg; Keown, J. F.; VanVleck, L. D.

in Revista Brasileira De Genetica (1995), 18(2), 237-243

Seven persistency measures and their relationships with total, partial and peak yields were studied. Heritabilities, genetic and phenotypic correlations were estimated using mixed model equations with ... [more ▼]

Seven persistency measures and their relationships with total, partial and peak yields were studied. Heritabilities, genetic and phenotypic correlations were estimated using mixed model equations with multiple trait restricted maximum likelihood (REML). Data were from 31,482 first lactation Belgian Holstein-Friesian cows. Differences in direction and size of the correlations between measures of persistency and total yield were found. Two types of measures were used. Persistency measures based on ratio showed positive correlations to total yield. Measures based on standard deviations of test, days or partial yields were correlated negatively with total yield. Correlations with partial yields also showed a similar pattern. Genetic correlations between ratio methods and peak yield were positive. Ratio methods not only describe persistency, but are highly influenced by total yield. Methods using standard deviations of test day yields showed a similar problem, but the influence of the level of total production was negative. Heritabilities of several persistency measures were above 0.10. After considering those results, a newly defined method, based on the standard deviation of partial yields, emerged as the best choice to describe persistency and for use in genetic evaluation of persistency. [less ▲]

Detailed reference viewed: 100 (0 ULg)
Peer Reviewed
See detailFra Stein til Waldrop: sprogdigtningen og de nye prosadigtere
Delville, Michel ULg; Schatz-Jakobsen, Claus

in Den Blå Port: Tidsskrift for Litteratur (1995)

Detailed reference viewed: 9 (2 ULg)
Peer Reviewed
See detailHysteroscopic myomectomy.
Donnez, Jacques; Polet, Roland; Smets, Mireille et al

in Current Opinion in Obstetrics & Gynecology (1995), 7(4), 311-6

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has ... [more ▼]

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has contributed to the prevention of fluid intravasion accidents. Effectiveness has been demonstrated in a number of recently published long-term studies. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailRelationship between transfusion regimen and suppression of erythropoiesis in beta-thalassaemia major.
Cazzola, M.; De Stefano, P.; Ponchio, L. et al

in British Journal of Haematology (1995), 89(3), 473-8

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion ... [more ▼]

In the management of beta-thalassaemia major, different transfusion schemes are employed with baseline haemoglobin levels ranging from 8 to over 12 g/dl. We studied the relationship between transfusion regimen and suppression of erythropoiesis in 52 patients with beta-thalassaemia major whose mean pretransfusion haemoglobin levels ranged from 8.6 to 10.9 g/dl. Multiple, regression analysis showed that serum transferrin receptor was the parameter more closely related to mean pretransfusion haemoglobin (r = -0.77, P < 0.001). As measured through serum transferrin receptor, erythroid activity was 1-2 times normal for pretransfusion haemoglobin levels between 10 and 11 g/dl. 1-4 times normal for levels from 9 to 10 g/dl, and 2-6 times normal for levels from 8.6 to 9 g/dl. Mean pretransfusion haemoglobin was also inversely related to serum erythropoietin (r = -0.72, P < 0.001), whereas it showed no or a weak relationship with Hb F, reticulocyte count, or circulating nucleated red cell count. This study suggests that serum transferrin receptor is a reliable indicator of suppression of erythropoiesis in beta-thalassaemia major. On the basis of our findings, pretransfusion haemoglobin values of < or = 9 g/dl should be adopted with caution, because these levels can be associated with an insufficient inhibition of erythroid marrow expansion. However, a transfusion programme, with a baseline haemoglobin of 9-10 g/dl, may provide enough suppression of erythropoiesis and allow a reduction in blood consumption as compared with the classic hyper- or supertransfusion schemes. Since fixed haemoglobin levels may not be the best target for transfusion treatment in all thalassaemic patients, assay of serum transferrin receptor may be helpful for individualizing the transfusion regimens. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Peer Reviewed
See detailPostgastroplasty recovery of ideal body weight normalizes glucose and insulin metabolism in obese women.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 364-9

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months ... [more ▼]

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months after successful gastroplasty (BMI, 23.7 +/- 0.6 kg/m2) in eight obese women and, for comparison, in eight age- and weight-matched nonobese control women (BMI, 23.6 +/- 0.7 kg/m2). All subjects had normal oral glucose tolerance. The insulin secretion rate (ISR) was derived by deconvolution of plasma C-peptide levels and the insulin MCR (MCRI) by dividing the 0-180 min area under the curve (AUC) of ISR by that of plasma insulin levels (IRI). The insulin sensitivity index (SI) and the glucose effectiveness index (SG) were calculated using Bergman's minimal model. Before gastroplasty, obese subjects showed higher AUC-IRI (P < 0.001) and AUC-ISR (P < 0.02), lower MCRI (P < 0.005) and SI (P < 0.002), but similar SG values, compared to nonobese controls. After gastroplasty, the AUC-IRI dramatically decreased, due to both a reduction of AUC-ISR (from 58,252 +/- 8,437 to 36,675 +/- 4,274 pmol; P < 0.05) and an increase in MCRI (from 658 +/- 117 to 1,299 +/- 127 mL/min.m-2; P < 0.02). SI significantly rose from 4.74 +/- 0.74 to 9.15 +/- 0.96 10(-5) min-1/pmol.L (P < 0.01), whereas SG remained unchanged. All of these parameters became similar to those in nonobese controls (respectively, 32,522 +/- 3,458, 1,180 +/- 101, and 8.48 +/- 1.25; all P = NS). In conclusion, after gastroplasty-induced normalization of body weight, postobese women recover normal insulin secretion, clearance, and action on glucose metabolism. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Peer Reviewed
See detailPost-operative erythropoiesis is limited by the inflammatory effect of surgery on iron metabolism.
Biesma, D. H.; Van de Wiel, A.; Beguin, Yves ULg et al

in European Journal of Clinical Investigation (1995), 25(6), 383-9

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible ... [more ▼]

The decrease in haemoglobin concentration commonly observed after major surgery is usually corrected by red cell transfusions or oral iron medication. The increased awareness of blood-transmissible diseases has led to the restrictive use of homologous blood and to interest in alternatives for correcting anaemia. We investigated the pathophysiology of postoperative anaemia by studying variables of erythropoiesis, iron metabolism, and inflammation in 48 consecutive patients who underwent total hip replacement. Haemoglobin concentration remained low during 14 days after surgery with only a mild increase in erythropoietin concentration and reticulocyte count. No increase in serum transferrin receptor concentration was observed during the first 2 weeks after surgery. Postoperative serum ferritin increased, whereas serum iron, transferrin and transferrin saturation decreased significantly. There was a marked increase in interleukin-6 and C-reactive protein with maximal values on the 1st and 4th post-operative day, respectively. At 6 weeks after surgery, haemoglobin concentration and variables of iron metabolism were almost at the preoperative level and serum transferrin receptor concentration was significantly increased, indicating increased erythropoietic activity. These changes were preceded by the normalization of interleukin-6 and C-reactive protein levels. Haemoglobin, iron, transferrin, and ferritin concentrations were not influenced by iron therapy during the postoperative period and no differences of erythropoietic and iron variables were observed between transfused and non-transfused patients. In conclusion, post-operative erythropoiesis is associated with an inflammatory effect of surgery on iron metabolism, which can explain, despite a slightly increased production of erythropoietin, the persistence of anaemia and the lack of effect of iron supplementation after surgery. [less ▲]

Detailed reference viewed: 20 (3 ULg)
Peer Reviewed
See detailDélimitation des hinterlands des agglomérations urbaines au départ d’une image de télédétection
Donnay, Jean-Paul ULg

in Revue Belge de Géographie (1995), 3-4(59), 325-331

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailEffects of iproflavone and its metabolites on human articular chondrocytes
Bassleer, Corinne; Franchimont, Paul; Henrotin, Yves ULg et al

in Osteoarthritis and Cartilage (1995), 4

Detailed reference viewed: 46 (2 ULg)
Peer Reviewed
See detailExploration biologique actuelle du métabolisme du fer
Charlier, Corinne ULg; Plomteux, Guy ULg

in Revue de la Médecine Générale (1995), 123

Detailed reference viewed: 26 (0 ULg)
Full Text
Peer Reviewed
See detailINTERVALENCE TRANSITIONS IN MIXED-VALENCE BIS(TETRATHIAFULVALENE) COMPOUNDS
Lahlil, Khalid; Moradpour, Alec; Bowlas, Christopher et al

in Journal of the American Chemical Society (1995), 117(40), 9995-10002

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds ... [more ▼]

The series of new bis(tetrathiafulvalene) [bis(TTF)] compounds 10-12a,b have been synthetized with the TTF-like synthon 8a,b, previously used to prepare the pyrazine-fused bis(TTF) 7a,b. These compounds exhibit four reversible sequential one-electron oxidation steps, on the basis of cyclic voltammetry. For the cation radicals 7b(.+), 10(.+), and 12(.+), generated electrochemically, rather intense and broad bands in the near-IR region, specific of class II mixed valence compounds, were found. Theoretical calculations at the semiempirical AM1 level as well as at the ab-initio level indicated that these cation radicals are charge-distributions localized as related to mixed valence species. These calculations also allowed the low-energy absorption bands to be assigned to intervalence transitions; these transitions imply the existence of multiple low-lying excited states that are non-adiabatically coupled to the ground-state of these open-shell species. [less ▲]

Detailed reference viewed: 48 (5 ULg)
Peer Reviewed
See detailLes insuffisances mitrales ischémiques: principes de leur traitement chirurgical
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 295-7

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou ... [more ▼]

L'insuffisance mitrale ischémique est une manifestation peu fréquente de la maladie cotanarienne. Elle constitue par ailleurs une entité relativement mal connue. Il peut s'agir de complications aiguës ou chroniques de la maladie ischémique. Leur compréhension est facilité par la classification fonctionnelle de Carpentier. A l'occasion de cette revue, nous précisons les indications elles modalités de traitement de ce type d'insuffisance mitrale. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Full Text
See detailAttitudes d’enfants de 6 à 12 ans à l’égard de l’éducation physique scolaire et de ses objectifs
Delfosse, Catherine; Cloes, Marc ULg; Ledent, Maryse et al

in Sport (1995), 149(1), 35-49

L'organisation d'une séance quotidienne d'éducation physique dans l'enseignement fondamental a longtemps été revendiquée par les professionnels de l'éducation physique. Des expériences déjà anciennes ... [more ▼]

L'organisation d'une séance quotidienne d'éducation physique dans l'enseignement fondamental a longtemps été revendiquée par les professionnels de l'éducation physique. Des expériences déjà anciennes augmentant la quantité d'activité physique - heure quotidienne, mi-temps ou tiers-temps pédagogiques - ont mis en évidence quelles applications pourraient être bénéfiques pour les enfant, surtout sur des aspects en relation avec les qualités physiques. ... [less ▲]

Detailed reference viewed: 44 (2 ULg)
Peer Reviewed
See detailCoexpression of cytokeratin and vimentin in eutopic endometrium and endometriosis throughout the menstrual cycle: evaluation by a computerized method.
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (1995), 64(1), 69-75

Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium. DESIGN: The investigation of cytokeratin and vimentin was ... [more ▼]

Objectives: To evaluate quantitatively cytokeratin and vimentin staining in glandular and stromal cells of eutopic and ectopic endometrium. DESIGN: The investigation of cytokeratin and vimentin was carried out using the new computerized technology of image analysis. SETTING: University Hospital, Department of Gynecology. PATIENTS: Biopsies were taken from patients undergoing a laparoscopy for infertility (29 endometrial biopsies and 31 biopsies of peritoneal endometriosis). None of them were treated. RESULTS: Cyclic variations of cytokeratin and vimentin staining were noted in eutopic endometrium. The cytokeratin and vimentin staining pattern consistently was lower in ectopic endometrium than in eutopic endometrium. CONCLUSIONS: Endometriotic epithelial and stromal cells undergo a complex program of differentiation giving them histochemical characteristics similar to those observed in endometrium. Such a concomitant expression of antigenicity indicates their close relationship with their mesodermal müllerian origin. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailEtude de la variabilité interindividuelle des potentiels evoques auditifs exogènes et endogènes en condition d'attention volontaire
Lembreghts, M.; Crasson, Marion ULg; el Ahmadi, A. et al

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(4), 203-23

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we ... [more ▼]

The use of P300 in psychopathology raises the important problem of the constitution of reference normative data and of the high variability of auditive ERP's in controls. To handle better this problem, we recorded 86 control subjects, using an auditory oddball paradigm with motor response. We analyzed the successive components of the ERP's evoked by target and standard stimuli (N1, P2, N2, P3a, P3b and slow wave negativity). Our results underlined the role of age, sex and psychological factors on the ERP's interindividual variability: P3 amplitude decreased and its latency increased with age, while its topography was more frontal in the older than in the younger subjects. The P300 occurrence after standard stimuli and P3 amplitude after target stimuli were different according to sex. Moreover, P300 amplitude, latency and topography were related to the subject's anxiety level. Finally, our results also propose new description modes of ERP's relying on P3a and P3b relative peak amplitude (P300 with prominent P3a or P3b), topographical predominance (frontal or parietal P300) and duration of the late positive complex (brief or long-lasting P300). These data will improve the clinical use of P300. [less ▲]

Detailed reference viewed: 44 (2 ULg)
See detailA Frequency-Domain Processor for ScanSAR Images
Barbier, Christian ULg; Rosello-Guasch, Josep

in Preparing for the Future (1995), 5(4), 6-7

Detailed reference viewed: 12 (2 ULg)
Peer Reviewed
See detailUse of a model to understand prolactin and growth hormone specificities
Goffin, Vincent; Martial, Joseph ULg; Summers, Neena L.

in Protein Engineering (1995), 8(12), 1215-31

A human prolactin (hPRL) model based on a 2.1 A resolution X-ray refinement of porcine growth hormone is reported. Only regions clearly defined in the growth hormone template (the four-helix bundle) or ... [more ▼]

A human prolactin (hPRL) model based on a 2.1 A resolution X-ray refinement of porcine growth hormone is reported. Only regions clearly defined in the growth hormone template (the four-helix bundle) or previously assumed to be involved in hPRL-receptor binding (the bundle and the binding site loop) are included. A description of the model construction is provided and the resulting hPRL structure is used to interpret mutation/activity data for the cross-reactivity of human growth hormone (hGH) with the lactogenic receptor and the binding of human and bovine prolactin to the lactogenic receptor. The recognition of hPRL by its receptor unexpectedly appears to resemble more closely the interaction of hGH with the somatogenic receptor than with the lactogenic receptor. Each hGH binds to two receptor molecules, and an essential second messenger mediated by correct formation of the receptor-receptor interface has been proposed. The absence of receptor cross-reactivity for hPRL is linked to key sequence changes in hPRL which could disrupt hPRL-somatogenic receptor binding at the second site. A number of previous experiments have relied on the assumption that bioactivity is mediated by homologous residues at topologically equivalent positions. According to the model, this does not appear to be strictly true at either binding site. Good correlation at equivalent positions may be restricted to residues that are important for maintaining binding site shape as well as providing complementary stabilizing interactions between the hormone and receptor. Experiments are proposed to test our hypotheses. [less ▲]

Detailed reference viewed: 6 (0 ULg)
Peer Reviewed
See detailThe flesinoxan 5-HT1A receptor challenge in major depression and suicidal behavior.
Pitchot, William ULg; Ansseau, Marc ULg; Gonzalez Moreno, A. et al

in Pharmacopsychiatry (1995), 28 Suppl 2

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature ... [more ▼]

The prevailing neurochemical theory about biological correlates of suicidal behavior focuses on the serotonergic system. In this study, we assessed the cortisol, ACTH, GH, prolactin and temperature responses to flesinoxan, a5-HT1A agonist, in 30 DSM-III-R major depressed inpatients subgrouped into suicide attempters (n = 15) and nonattempters (n = 15). The patients were assessed after a drug-free period of at least 3 weeks. A subsample of 16 patients completed the Buss-Durkee Hostility Inventory as a measure of impulsive aggressive behavior. Mean delta cortisol responses to flesinoxan were significantly lower in the group of depressed patients with a history of suicide attempts than in the group without history of suicidal behavior: for the delta cortisol values 14.5 +/- 16.3 micrograms/l vs 101 +/- 94 micrograms/l (F = 8.9, df = 5.25, p = 0.006). There was also a very significant difference between suicide attempters and nonattempters for the temperature (delta T degrees) responses to flesinoxan: 0.20 +/- 0.24 degrees C vs. 0.60 +/- 0.24 degrees C (F = 18.1, df = 5.25, p = 0.0003). Hormonal and temperature responses to flesinoxan were not correlated with BDHI irritability or assault subscale scores. The results of the present study support the implication of the serotonergic system, particularly 5-HT1A receptors, in the control of self-directed aggressive behavior. Moreover, in depressed patients, serotonergic abnormalities do not appear to be related to aggressive behavior. [less ▲]

Detailed reference viewed: 25 (3 ULg)
Peer Reviewed
See detailBiocronoestratigrafia de miosporos do Devoniano Medio – Carbonifero inferior das bacias do Solimoes e Parnaiba (Estado da arte).
Loboziak, S; Melo, JHG; Quadros, LP et al

in Annals Academia Braziliensis Ciencas (1995), 67(3), 394-395

Detailed reference viewed: 22 (0 ULg)
Peer Reviewed
See detailSpécificités cardio-respiratoires de la médecine sportive équine
Lekeux, Pierre ULg; Art, Tatiana ULg

in Médecine du Sport (1995), 69

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailFinite-amplitude regimes of the short-wave Marangoni-Benard convective instability.
Colinet, Pierre; Legros, Jean-Claude; Kamotani, Y. et al

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1995), 52(3), 2603-2616

Detailed reference viewed: 10 (1 ULg)
See detailTémoignages de la spiritualité néolithique au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

Detailed reference viewed: 28 (1 ULg)
Full Text
Peer Reviewed
See detailCryptocrine Signaling in the Thymus Network and T Cell Education to Neuroendocrine Self-Antigens
Geenen, Vincent ULg; Goxe, Béatrice; Martens, Henri ULg et al

in Journal of Molecular Medicine : Official Organ of the 'Gesellschaft Deutscher Naturforscher und Ärzte' (1995), 73(9), 449-55

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental ... [more ▼]

Both during phylogeny and ontogeny the thymus appears as a nodal point between the two major systems of cell-to-cell signaling, the neuroendocrine and immune systems. This review presents the experimental observations which support a dual role in T cell selection played by the thymic repertoire of neuroendocrine polypeptide precursors. Through the mode of cryptocrine intercellular signaling thymic neuroendocrine-related precursors synthesized in thymic epithelial cells have been shown to influence the early steps in T cell differentiation. In addition, thymic neuroendocrine-related polypeptides are a source of self-antigens which are presented by the major histocompatibility system of the thymic epithelium. Preliminary data also suggest that the intrathymic T cell education to neuroendocrine self-antigens is not strictly superimposible to the antigen presentation by dedicated presenting cells. Insulin-like growth factor-II (IGF-II) was identified as one dominant member of the insulin family expressed by thymic epithelial and nurse cells. The intrathymic presentation of IGF-II or IGF-II derived self-antigens is under current investigation. If further confirmed, the central tolerogenic properties of IGF-II could be considered in the elaboration of a strategy for an efficient and safe prevention of insulin-dependent diabetes. [less ▲]

Detailed reference viewed: 18 (6 ULg)
Full Text
Peer Reviewed
See detailOxidation of organic substrates with potassium ferrate (VI) in the presence of the K10 montmorillonite
Delaude, Lionel ULg; Laszlo, Pierre ULg; Lehance, Pascal

in Tetrahedron Letters (1995), 36(46), 8505-8508

Among various aluminosilicate supports, the K10 montmorillonite clay was the best catalyst for the oxidation of organic substrates with potassium ferrate (VI). Thus, a solid mixture of K2FeO4 and K10 has ... [more ▼]

Among various aluminosilicate supports, the K10 montmorillonite clay was the best catalyst for the oxidation of organic substrates with potassium ferrate (VI). Thus, a solid mixture of K2FeO4 and K10 has been used for the efficient oxidation of selected alcohols, benzylamine, thiophenol, and aniline in hydrocarbon solvents at room temperature. Somewhat humid clay performs best, and it is important to control the amount of water associated to the solid support. [less ▲]

Detailed reference viewed: 50 (0 ULg)
Full Text
Peer Reviewed
See detailSurface Molecular Structure of Self-Assembled Alkanethiols Evidenced by UPS, Synchrotron Radiation and HREELS
Duwez, Anne-Sophie ULg; Riga, Joseph; ghijsen, Jacques et al

in Journal of Electron Spectroscopy & Related Phenomena (1995), 76

Detailed reference viewed: 5 (1 ULg)
Peer Reviewed
See detailCognitive Functions in Migraine without Aura between Attacks: A Psychophysiological Approach Using The "Oddball" Paradigm
Wang, W.; Schoenen, Jean ULg; Timsit-Berthier, M.

in Neurophysiologie Clinique = Clinical Neurophysiology (1995), 25(1), 3-11

"Oddball" paradigm studies of auditory P300 have yielded conflicting results in migraine. We therefore undertook an additional study of auditory event-related potentials (ERPs) using an improved method of ... [more ▼]

"Oddball" paradigm studies of auditory P300 have yielded conflicting results in migraine. We therefore undertook an additional study of auditory event-related potentials (ERPs) using an improved method of EEG processing, strict criteria for patients selection, and comparison with behavioral data. Twenty-one healthy subjects were compared to 20 patients suffering from migraine without aura between attacks. Migraine patients differed significantly from control subjects on several parameters: shorter latency of N1 (Cz) evoked by standard stimuli, longer latencies of both P3a and P3b (Pz) evoked by target stimuli, longer interval between N1 and P3b (Cz), smaller P3b (Cz) amplitude, longer reaction time (RT), higher number of errors (false alarm and/or omissions) and higher mean score on Plutchik-Van Praag's (PVP) inventory for depression. Errors were significantly correlated with RT and PVP scores. From a behavioral perspective, these results may suggest that patients suffering from migraine without aura between attacks display a higher level of arousal and more superficial attention, but require more time for automatic and/or voluntary processes. According to the inverted U-shaped relationship between performance and arousal, these patients may have difficulties in adjusting their attention level to perform a task in a optimal way. [less ▲]

Detailed reference viewed: 17 (5 ULg)
Full Text
Peer Reviewed
See detailEffect of high osmolarity acclimation on tolerance to hyperosmotic shocks in L929 cultured cells.
Gilles, Raymond ULg; Belkhir, M.; Compère, Philippe ULg et al

in Tissue & Cell (1995), 27(6), 679-687

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin ... [more ▼]

Application of abrupt, large hyperosmotic shocks induces in L929 cultured cells changes similar to those previously described in other cell types, notably a hypercondensation of the nuclear chromatin. This paper shows that; 1) this phenomenon is concomitant with a complete disappearance of deoxyribonucleic acid, as visualized by immunogold labelling, from the nucleoplasmic spaces; 2) acclimation to high osmolarities (600 mOsm) by addition to the culture medium of NaCl, sorbitol or proline protects the cells from these effects, which appear to be largely attenuated-acclimated cells also survive much better to the osmotic shock than do control cells and; 3) the best protection seems to be provided by sorbitol and NaCl. Proline acclimation is less effective. These effects are discussed in terms of increased tolerance to NaCl load induced at the level of different macromolecules by so-called 'compensatory' organic compounds. [less ▲]

Detailed reference viewed: 34 (3 ULg)
See detailLa naissance de l'écriture au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

Detailed reference viewed: 19 (0 ULg)
Peer Reviewed
See detailFactors regulating megakaryocyte progenitor commitment to polyploidization.
Paulus, Jean-Michel ULg; Grosdent, J C; Prenant, M et al

in Comptes Rendus de l'Académie des Sciences. Série III. Sciences de la Vie (1995), 318(3), 381-6

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms ... [more ▼]

Recognizable megakaryocytes are polyploid cells generated by a clonogenic, diploid progenitor, termed CFU-MKC (colony forming unit, megakaryocyte). In order to quantify polyploidization, ploidy histograms of megakaryocytes determined by microphotometric or flow cytometric measurements of megakaryocyte DNA have generally been used. However these techniques provide no information on the rate of commitment of CFU-MKC to polyploidy. Using a technique of clonal analysis determining the distributions of the number of doublings (NbD) undergone by CFU-MKC before committing to polyploidization, the polyploidization probability of CFU-MKC could be derived. This probability was found to be a constant independent from CFU-MKC mitotic history, since NbD distributions are exponential functions characterized by a constant rate of decay per doubling. By studying the effects of growth factors on polyploidization probability, it was also shown that: (1) this parameter is negatively regulated by growth factors contained in poke-weed or WEHI conditioned media, as well as by erythropoietin; (2) commitment to polyploidization does not require prior CFU-MKC division; (3) bipotent erythroid-megakaryocyte progenitors have a lower polyploidization probability than CFU-MKC; (4) determination of polyploidization probability reflects the activity of growth factors with greater accuracy than megakaryocyte colony count. [less ▲]

Detailed reference viewed: 14 (1 ULg)
See detailIn vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide
Ezzat, S.; Kontogeorgos, G.; Redelmeier, D. A. et al

in European Journal of Endocrinology (1995), 133

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailLe determinisme genetique de la differenciation sexuelle humaine.
Ectors, Fabien ULg

in Revue Médicale de Bruxelles (1995), 16(6), 404-10

The genetic mechanism controlling sexual differentiation had remained unknown for a long time. Karyotype analysis of sex-inverted patients or individuals with ambiguous sexual differentiation has enabled ... [more ▼]

The genetic mechanism controlling sexual differentiation had remained unknown for a long time. Karyotype analysis of sex-inverted patients or individuals with ambiguous sexual differentiation has enabled the localization and identification of genes involved. It is currently known that the SRY gene is responsible for the initiation of a cascade reaction leading to male differentiation of the primitive gonad. SRY is a +/- 820 base pairs gene located on the small arm of the Y chromosome, more precisely within the 1A1 alpha sub-segment. Although a few other genes are known to be involved in the downstream regulation of SRY, their precise mode of action is yet unknown. [less ▲]

Detailed reference viewed: 33 (0 ULg)
Full Text
Peer Reviewed
See detailCombined radiotherapy and radioimmotherapy of human colon carcinoma grafted in nude mice.
Buchegger, F; Rojas, A; Delaloye, A et al

in Cancer Research (1995), 55

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were ... [more ▼]

The effect of combined radioimmunotherapy (RIT) and fractionated external beam radiotherapy (RT) was assessed in two human colon cancer xenografts, Col 12 and LS174T in nude mice. These tumors were selected for being resistant to RIT alone, as is usually the case in the clinical situation. Tumor-bearing mice were treated with a combination of five X-ray fractions over 5 days followed by RIT with two doses of 1.5 mCi 131I-labeled anticarcinoembryonic antigen monoclonal antibody F(ab')2. In Col 12 and LS174T, RIT alone achieved a regrowth delay similar to that of fractionated RT with total doses of 28 and 26 Gy, respectively. In both tumor types, an additive therapeutic effect, measured as increased regrowth delay or local control, was observed when combining RT of different dose levels with RIT. Normal tissue responses were assessed by monitoring acute peak skin reactions and blood cell count. Bone marrow depression for the combination treatment was similar to that of RIT alone; relative to skin, at equitoxic levels, no mice bearing Col 12 tumors were locally controlled with a 32 Gy RT dose alone, while this RT combined with RIT gave a local control of 100%. These studies show a therapeutic benefit when external beam RT is combined with RIT. [less ▲]

Detailed reference viewed: 17 (5 ULg)
Full Text
Peer Reviewed
See detailÉvaluation de l’impact de la végétation sur le rayonnement énergétique (aide à la conception architecturale et urbanistique)
Teller, Jacques ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

Detailed reference viewed: 53 (19 ULg)
Full Text
Peer Reviewed
See detailIndice plasmodique et parasitémie à Plasmodium falciparum: valeur diagnostique et pronostique au Congo.
Carme, B.; Hayette, Marie-Pierre ULg; Mbitsi, A. et al

in Annales de la Société Belge de Médecine Tropicale (1972) (1995), 75

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the ... [more ▼]

Parasitological data of various malarial studies performed in the Congo where Plasmodium falciparum malaria is holoendemic in rural and suburban zones between 1988 and 1991, were analyzed with the intention of establishing diagnosis and prognosis value of Plasmodium falciparum parasitaemia in areas with high perennial transmission. In such an area Congolese school children (6-10 years old) had 88% P. falciparum index, this is the same percentage as that for children hospitalized with a pernicious attack. However, the parasite load is distributed differently; parasitaemia is greater than 6,000 asexual form for P. falciparum (af/Pf/µl) in only 4,6% of cases in the former group, versus 67% in the second group. A threshold of 10,000 af/Pf/µl above which the Plasmodium infection triggers a febrile attack in semi-immune children, is confirmed in school children in a rural context where the factor of taking antimalarial drugs within the preceding days is negligible: three out of four children with levels above this threshold are febrile versus 4,1% (7 out of 170) with lower blood parasite levels. Some adults where also asymptomatic carriers but much less frequently and with lower mean parasitaemia levels. The parasite load mirrors the clinical severity although this concept can be misleading as an individual prognostic criterion and foor hospital studies carried out in areas where multiple drug administration before hospitalization is common. For the studies recently performed in Brazzaville, the 5% threshold of parasitized red cells, the WHO severity criterion was never reached in asymptomatic subject or in cases of simple attack; it was reached in one out of two cases of pernicious attack. [less ▲]

Detailed reference viewed: 244 (1 ULg)
Peer Reviewed
See detailTwo forms of lipase from Mucor miehei exhibit a different behavior at the air-water interface.
Blecker, Christophe ULg; Razafindralambo, Hary ULg; Paquot, Michel ULg et al

in Colloids and Surfaces B : Biointerfaces (1995), (3), 271-279

Detailed reference viewed: 19 (7 ULg)
Peer Reviewed
See detailneuroendocrinology in the perinatal period
Battisti, Oreste ULg

in mini acta of belgian society of pediatrics (1995), 27

Detailed reference viewed: 12 (4 ULg)
Peer Reviewed
See detailSoya oil in diet for growing-fattening bulls: I. Effects on animal performances and carcass composition
Clinquart, Antoine ULg; Van Eenaeme, Christian ULg; Dufrasne, Isabelle ULg et al

in Journal of Animal Physiology & Animal Nutrition (1995), 74

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailBovine respiratory disease complex : an european perspective
Lekeux, Pierre ULg

in Bovine Practitioner (1995), 29

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune ... [more ▼]

Respiratory disease is the principal cause of loss of young cattle worldwide. The syndrome arises from a number of factors, including those involving the animal, e.g., age, general condition and immune status; its environment, e.g., changes in food, temperature and humidity that lead to stress; and the presence of infectious agents, e.g., bacteria, viruses and mycoplasmas. The syndrome, in a method preferred by the author, can be classified into four grades; Grade 1, subclinical disease; Grade 2, compensated clinical disease (at this stage, the inflammatory reaction generated tends to limit the impact of the disease on the animal); Grade 3, noncompensated clinical disease (at this stage, the inflammatory reaction is excessive and must be controlled); and Grade 4, irreversible clinical disease (which threatens the animal's survival). The increase in frequency and economy impact of bovine respiratory disease complex can be correlated with the escalating industrialization of cattle production. In intensive operations, commingling of animals from multiple sources, exposure to many organisms, stress and management practices are all factors that can lead to disease. The predisposition of cattle, especially beef calves, to respiratory problems is related to their lack of functional pulmonary hardiness. Selection of breeds that demonstrate adequate pulmonary function and sufficient ventilatory reserve may help in the control of the bovine respiratory disease complex, but this approach is difficult to implement and slow to produce results. Prophylactic measures, including vaccination programs and modifying management practices to reduce stress, also have a place in preventing the bovine respiratory disease complex. Unfortunately, these measures are not always easy to put into operation and cannot completely eradicate the problem. Therapeutic strategies to minimize the economy impact of the syndrome include use of appropriate antibacterial therapy, modulation of the pulmonary inflammatory reaction and correction of mechanical disorders. [less ▲]

Detailed reference viewed: 178 (6 ULg)
Peer Reviewed
See detailL'axe sol-plante-animal dans les tétanies d'herbe
Dufrasne, Isabelle ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1995), 139

Detailed reference viewed: 20 (11 ULg)
Full Text
Peer Reviewed
See detailMiospore Biozonation in the Middle Devonian - Lower Carboniferous of Europe : its application to Western Gondwana
Loboziak, S.; Streel, Maurice ULg

in Anais da Academia Brasileira de Ciencias (1995), 67(3), 311-312

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailDe l’Utopie au Non-Lieu. Genèse d’un campus : le « Domaine universitaire » du Sart Tilman
Durand, Pascal ULg; Winkin, Yves ULg; De Smet, Fabienne

in Espaces et Sociétés (Paris, France) (1995), 80/81

Detailed reference viewed: 47 (15 ULg)
Full Text
Peer Reviewed
See detailRegulation Of The Beta-Lactamase Blal Of Streptomyces-Cacaoi - The Product Of The Blab Regulatory Gene Is An Internal Membrane-Bound Protein
Magdalena, J.; Joris, Bernard ULg; Vanbeeumen, J. et al

in Biochemical Journal (1995), 311

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open ... [more ▼]

The beta-lactamase-encoding gene blaL, cloned from Streptomyces cacaoi in Streptomyces lividans, is inducible by beta-lactam compounds. This regulation has been shown to depend on the products of two open reading frames, ORF1 (blaA) and ORF2 (blaB) [Lenzini, Magdalena, Fraipont, Joris, Matagne and Dusart (1992) Mol. Gen. Genet. 235, 41-48]. BlaA belongs to the LysR family of transcription activators, whereas BlaB shares some features with the penicillin-recognizing proteins. BlaB has now been overexpressed in Escherichia coli, purified and used for antibody preparation. Immunoblotting of cell-fractionated materials from S. cacaoi showed that BlaB is attached to the internal face of the cytoplasmic membrane. It could not be released by high salt concentrations or EDTA, but only by protease treatment. Under the assay conditions, BlaB did not act as a penicillin-binding protein, a beta-lactamase, a D-amino-peptidase or a target in a phosphorylation step. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Peer Reviewed
See detailNucleic acid compartmentalization within the cell nucleus by in situ transferase-immunogold techniques.
Thiry, Marc ULg

in Microscopy Research and Technique (1995), 31(1), 4-21

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is ... [more ▼]

In the present review, we report on recent results obtained by in situ transferase-immunogold techniques as to the ultrastructural distribution of DNA and RNA within the cell nucleus. Special emphasis is placed on the various nucleolar components and the various enigmatic structures of the extranucleolar region: interchromatin granules, coiled bodies, and simple nuclear bodies. These data are discussed in the light of our current understanding of the functional organization of the cell nucleus. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailAcquis de la recherche en matière d'évaluation génétique des ovins et des caprins en Tunisie
D'Jemali, M'naouer; Jamal, Sofiene; Ben-Dhiaf, Sonia et al

in Cahiers Options Méditerranéennes (1995), 11

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 ... [more ▼]

Work carried out on performance recording for growth and milk yield in sheep and goats for use in genetic evaluation is briefly summarized, and preliminary data on the growth and reproductive traits of 9 flocks of Barbary sheep in 1987-92 are presented in 14 tables and discussed. [less ▲]

Detailed reference viewed: 171 (5 ULg)
Full Text
Peer Reviewed
See detailInter-individual variability of teachers' feedback: Study in simulated teaching conditions
Cloes, Marc ULg; Denève, Alain; Piéron, Maurice ULg

in European Physical Education Review (1995), 1(1), 83-93

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à ... [more ▼]

Dans l'enseignement des activités physiques, les réactions de l'enseignant à la prestation des élèves (feedback) constituent l'une des variables déterminantes dans la réussite pédagogique. Les réactions à la prestation se caractérisent par une grande variabilité interindividuelle. Leur émission fait suite à un processus comportant deux phases: le diagnostic et la prescription. Afin de mettre en évidence le rôle exercé par les facteurs liés aux caractéristiques de l'enseignant sur celles de leurs interventions, nous avons comparé les réactions à la prestation émises par 12 éducateurs physiques lors d'une séance d'enseignement simulé. Grâce à cette technique vidéo, les sujets réagissent à partir de performances motrices identiques. Les feedback ont été comparés entre quatre groupes de sujets caractérisés par des niveaux d'expérience sportive et pédagogique similaires. Une analyse factorielle par correspondance a permis d'identifier des classes de sujets émettant des feedback de même type. Les résultats tendent à souligner que (1) le niveau d'expertise dans la pratique de l'activité enseignée exerce une influence sur la première de ces phases; (2) le degré d'expertise pédagogique contribue à améliorer l'émission du message. [less ▲]

Detailed reference viewed: 72 (3 ULg)
Peer Reviewed
See detailISOLATION OF SUCROSE SYNTHASE FROM RICE (ORYZA-SATIVA) GRAINS IN PILOT-SCALE FOR APPLICATION IN CARBOHYDRATE SYNTHESIS
ELLING, Lothar; GULDENBERG, Birgit; GROTHUS, Marita et al

in Biotechnology & Applied Biochemistry (1995), 21(Part 1), 29-37

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the ... [more ▼]

The application of sucrose synthase as a valuable biocatalyst for the synthesis of activated sugars and saccharides requires large amounts of enzyme. The purification of sucrose synthase starting from the 9 kg scale of rice (Oryza sativa) grains was achieved in five steps with 11.3% yield and 192-fold purification. The final sucrose synthase preparation was free of nucleotide di- and monophosphatases, but did contain 0.05% of both invertase and UDP-glucose-hydrolysing activity. It can be efficiently utilized for the synthesis of activated sugars. Its application for the synthesis of saccharides is possible taking into account that 15% UDP-glucose is hydrolysed within 15 h incubation time [less ▲]

Detailed reference viewed: 64 (7 ULg)
Full Text
Peer Reviewed
See detailSynthesis And Antimicrobial And Toxicological Studies Of Amino-Acid And Peptide Derivatives Of Kanamycin-A And Netilmicin
Kotretsou, S.; Mingeotleclercq, Mp.; Constantinoukokotou, V. et al

in Journal of Medicinal Chemistry (1995), 38(23), 4710-9

Amino acid and peptide derivatives of aminoglycosides have been obtained by substitution of the 1-N or 6'-N amino functions of kanamycin A and netilmicin via the temporary complexation of vicinal and ... [more ▼]

Amino acid and peptide derivatives of aminoglycosides have been obtained by substitution of the 1-N or 6'-N amino functions of kanamycin A and netilmicin via the temporary complexation of vicinal and nonvicinal amino and hydroxy functions by copper ion [1-N kanamycin A derivatives: L-Ala (6a), D-Ala (6b), Gly (6c), L-Asp (6d), L-Ala-L-Ala (6e). 6'-N kanamycin A derivatives: L-Ala (3a), D-Ala (3b), Gly (3c), L-Ala-L-Ala (3e), L-Leu (3f). 6'-N netilmicin derivatives: L-Ala (9a), D-Ala (9b), Gly (9c), L-Asp (9d), L-Ala-L-Ala (9e)]. Characterization was made by FAB-MS, IR, 1H-NMR, and 13C-NMR. All derivatives were essentially inactive. The nephrotoxic potential of the derivatives obtained in sufficient quantities (3b,e and 9a-e) was assessed by measuring their inhibitory potential toward the activity of lysosomal phospholipase A1 acting on phosphatidylcholine embedded in negatively-charged membranes. One compound, 6'-N-L-Ala-netilmicin (9a), showed a 2-fold decrease of inhibitory potency compared to its parent drug. A conformational analysis revealed that it adopts two equally probable conformations and orientations when interacting with phosphatidylinositol. The first in which the drug lies parallel to the hydrophobic-hydrophilic interface, is similar to that of netilmicin. The second, in which the drug inserts itself in the bilayer across the hydrophilic/hydrophobic interface, is similar to that described for streptomycin, an almost non-nephrotoxic aminoglycoside. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailBiopharmaceutical aspects of the development of a sulfamethazine oral sustained release bolus for lambs
Evrard, Brigitte ULg; Delahaut, P.; Hubert, Philippe ULg et al

in Journal of Controlled Release (1995), 35

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the ... [more ▼]

Pharmacokinetic parameters of sulfamethazine (SMZ) administered intravenously or orally either as an aqueous solution or as a lipid matrix formulation, were determined in young lambs. The value of the rate constant for elimination (ke) for the intravenous solution was 0.18 h−1 compared to 0.10 h−1 for the oral aqueous solution. The absolute bioavailability of the oral solution was about 75%. A lipid matrix containing SMZ and a high density excipient is able to be retained in the reticulo-rumen and to produce a sustained release of the drug for at least 100 h provided that the mechanical strength of the bolus is sufficient. The pharmacokinetic data obtained with the lipid matrix show a release profile with two pulses due to both diffusion and erosion mechanisms. Plasma levels are maintained above the MIC of SMZ during 100 h with an absolute bioavailability of 51.7% [less ▲]

Detailed reference viewed: 12 (1 ULg)
Peer Reviewed
See detailThe use of Sandimmun (cyclosporin A) in severe refractory rheumatoid arthritis: the Belgian experience
Malaise, Michel ULg; De Keyser, P.; De Backer, M. et al

in Clinical Rheumatology (1995), 14

OBJECTIVE: To investigate practicability, efficacy and tolerability of low starting doses of Sandimmun (cyclosporin A) (2.5 mg/kg daily) in patients with severe refractory rheumatoid arthritis in the ... [more ▼]

OBJECTIVE: To investigate practicability, efficacy and tolerability of low starting doses of Sandimmun (cyclosporin A) (2.5 mg/kg daily) in patients with severe refractory rheumatoid arthritis in the short (6 months) and middle (12 months) term. METHODS: Fifty-nine patients, presenting with active and severe rheumatoid arthritis unresponding to conventional DMRADs were allowed to start Sandimmun at the dose of 2.5 mg/kg daily. This dose was progressively increased by steps of 25 mg daily up to a maximum of 5 mg/kg daily according to the renal function and blood pressure. RESULTS: A mean maintenance dose of 3.9 mg/kg daily was reached after 5 months and maintained throughout the study. Twenty-one patients (36%) completed the one year study. The reasons for discontinuation were: inefficacy (13), adverse events (17), both inefficacy and adverse events (5) and non-compliance (3). For those patients who completed the trial, clinical relevant improvements were observed within 3 months of treatment and were maintained until the end of the study for the Lee functional and the Ritchie articular index, as well as for the number of tender and swollen joints. No changes for the grip strength, the biological and immunological parameters were observed. Mean serum creatinine values rose from 0.81 mg/dl at start to 1.1 mg/dl after 5 months of therapy and remained at that level throughout the study. In patients who discontinued, the serum creatinine level nearly normalized after one month of Sandimmun withdrawal. One hundred and sixty-two side effects were reported of which most were minor and known to occur with Sandimmun. Twenty-two cases (37% of patients) dropped out for adverse events before 1 year treatment. The criteria to withdraw the patients from the study differed greatly from centre to centre. CONCLUSIONS: Managing RA patients presenting with very long and severe disease remains difficult. Therefore low dose Sandimmun (2.5-5 mg/kg daily) appears to be a valuable therapeutic opportunity in RA patients refractory to various other conventional drugs, including methotrexate. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailThe pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain.
Peers, Bernard ULg; Sharma, S.; Johnson, T. et al

in Molecular & Cellular Biology (1995), 15(12), 7091-7

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most ... [more ▼]

A number of homeodomain proteins have been shown to regulate cellular development by stimulating the transcription of specific target genes. In contrast to their distinct activities in vivo, however, most homeodomain proteins bind indiscriminately to potential target sites in vitro, suggesting the involvement of cofactors which specify target site selection. One such cofactor, termed extradenticle, has been shown to influence segmental morphogenesis in Drosophila melanogaster by binding cooperatively with certain homeodomain proteins to target regulatory elements. Here we demonstrate that STF-1, an orphan homeodomain protein required for pancreatic development in mammals, binds cooperatively to DNA with Pbx, the mammalian homolog of extradenticle. Cooperative binding with Pbx requires a pentapeptide motif (FPWMK) which is well conserved among a large subset of homeodomain proteins. The FPMWK motif is not sufficient to confer Pbx cooperativity on other homeodomain proteins, however; the N-terminal arm of the STF-1 homeodomain is also essential. As cooperative binding with Pbx occurs on only a subset of potential STF-1 target sites, our results suggest that Pbx may specify target gene selection in the developing pancreas by forming heterodimeric complexes with STF-1. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailA PARAMETRIC ANALYSIS FOR THE DAFALIAS-KALIAKIN BOUNDING SURFACE VISCOPLASTIC MODEL-BASED ON THE DIFLUPRESS LD TEST
LEIDWANGER-RABIS, Cathy; CHAMBON, René; CATEL, P. et al

in Computers & Geotechnics (1995), 17(4), 473-505

In order to predict delayed settlements of heavy structures, the authors decided to use the elasto-viscoplastic model of Dafalias-Kaliakin. To identify the parameters of the constitutive equations, they ... [more ▼]

In order to predict delayed settlements of heavy structures, the authors decided to use the elasto-viscoplastic model of Dafalias-Kaliakin. To identify the parameters of the constitutive equations, they use above all the data of a new in-situ test, the Diflupress L.D. designed to approach the creep behavior of soil. In a first section, the principle of the model is presented. Then, the important parameters of the model are identified, mostly from in-situ test data since the laboratory tests data are not numerous and reliable. Finally, a study of sensitivity on the parameters which influence the viscoplastic response of the model is made. [less ▲]

Detailed reference viewed: 45 (2 ULg)
Full Text
Peer Reviewed
See detailExégèse de Paul. D. 39,3 (de aqua et aquae pluviae arcendae), 2,6
Gerkens, Jean-François ULg

in Tijdschrift voor Rechtsgeschiedenis (1995), 63(1995/1), 11-26

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailOverexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria.
Van Dyck, E.; Jank, B.; Ragnini, A. et al

in Molecular & General Genetics [=MGG] (1995), 246

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast ... [more ▼]

The PIF1 and MRS2 gene products have previously been shown to be essential for mitochondrial DNA maintenance at elevated temperatures and mitochondrial group II intron splicing, respectively, in the yeast Saccharomyces cerevisiae. A multicopy suppressor capable of rescuing the respiratory deficient phenotype associated with null alleles of either gene has been isolated. This suppressor is a nuclear gene that was called RIM2/MRS12. The RIM2/MRS12 gene encodes a predicted protein of 377 amino acids that is essential for mitochondrial DNA metabolism and proper cell growth. Inactivation of this gene causes the total loss of mitochondrial DNA and, compared to wild-type rhoo controls, a slow-growth phenotype on media containing glucose. Analysis of the RIM2/MRS12 protein sequence suggests that RIM2/MRS12 encodes a novel member of the mitochondrial carrier family. In particular, a typical triplicate structure, where each repeat consists of two putative transmembrane segments separated by a hydrophilic loop, can be deduced from amino acid sequence comparisons and the hydropathy profile of RIM2/MRS12. Antibodies directed against the aminoterminus of RIM2/MRS12 detect this protein in mitochondria. The function of the RIM2/MRS12 protein and the substrates it might transport are discussed. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailMeasurement of glucosinolates in rapeseeds.
Wathelet, Jean-Paul ULg; Marlier, M.; Severin, M. et al

in Natural toxins (1995), 3(4),

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of ... [more ▼]

Several ring tests have been organized by the International Organisotion for Standardization (lSO) and the Measurement ônd Testing Programme (BCR) for improving glucosinolote methods Finally, HPLC of desulphoglucosinolates is recommended by lSO, the European Committee for Standardizotion (CEN), and the European Commission (EC) as the official method. X-ray fluorescence has also become particularly common for fast analysis. After checking stability of intact glucosinolates in whole rapeseeds, the BCR has three reference materials (CRM 366, CRM 190, CRM 367) avai able, certified for their total glucosinolate and sulphur contents. Currently, the Measurement and Testing Programme is supporting a research project concerning the stdbility of desulphoglucosinolates and intact glucosinolates extracts. At the present time, best results were observed with lyophilized extracts sealed in brown glass ampoules and stored at 18'C. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Peer Reviewed
See detailAspects hémodynamiques de l'insulinorésistance: des concepts théoriques à la thérapeutique.
Paquot, Nicolas ULg; SCHEEN, André ULg; Lefebvre, P.

in Médecine et Hygiène (1995), 53

Detailed reference viewed: 4 (0 ULg)
Peer Reviewed
See detailLes confraternités de l'abbaye de Stavelot-Malmedy
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1995), CLXI

réseau de fraternités de Stavelot-Malmdy mis en parallèle avec tous les échanges humains observés dans toutes les sources

Detailed reference viewed: 19 (4 ULg)