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See detailExpansive benign lesions: treatment by laser.
Smets, Mireille; NISOLLE, Michelle ULg; Bassil, Salim et al

in European Journal of Obstetrics and Gynecology (1996), 65(1), 101-5

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ... [more ▼]

Submucous fibroids, polyps and dysfunctional bleeding are responsible for meno-metrorrhagia in women over 40 years of age. The authors describe the technique of hysteroscopic myomectomy and endometrial ablation using the Nd-YAG laser and the advantages of the preoperative use of GnRH agonist therapy. They report their results in a series of 746 patients treated for meno-metrorrhagia (366 cases of myomectomy and 380 cases of endometrial ablation). [less ▲]

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See detailInsulin action in man.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(2), 105-10

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is ... [more ▼]

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues and for the prevention of excessive gluconeogenic substrate production. Various methods have been developed to assess insulin action in vivo, essentially at liver and muscle sites. Such methods evaluate the effect of exogenous or endogenous insulin, using respectively the open-loop approach (interruption of the feedback loop by inhibiting endogenous insulin secretion) or the closed-loop approach (mathematical modelling of the insulin-glucose feedback loop). Knowledge of the successive steps of cellular insulin action has markedly improved during the last ten years. Preceptor, receptor and postreceptor levels need to be considered since they may be affected in insulin-resistant states. This general progress in the understanding of insulin action in man improves our approach to the complex pathophysiology of non-insulin-dependent diabetes mellitus and opens up new prospects for treatment of the insulin-resistant syndrome which is associated with several atherosclerotic risk factors. [less ▲]

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See detailQuelques documents inédits relatifs à Guillaume Lekeu
Pirenne, Christophe ULg; Dado, Stéphane; Verdebout, Luc

in Revue de la Société liégeoise de Musicologie (1996), 5

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See detailEvaluation de l'effet apaisant d'un dermocosmétique: Soin intense apaisant
Nikkels, Arjen ULg; Jacquet, A.; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1996), 15

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation ... [more ▼]

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation and sites chromametry) and indirect investigations (corneocyte harvesting and chromametric analysis) have been conducted. The excellent correlation between the results has lead us to prove a very obvious soothing effect of SOIN INTENSE APAISANT (care range Hydrocapteur of Castalia, Laboratoires Lavipharm). [less ▲]

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See detailModelling of multiphase flow in packed beds by computer-assisted x-ray tomography
Toye, Dominique ULg; Marchot, Pierre ULg; Crine, Michel ULg et al

in Measurement Science & Technology (1996), 7(3), 436-443

The high resolution which can be obtained by computer-assisted x-ray tomography is used to investigate Various scale heterogeneities of the flow texture characterizing multiphase flow in packed beds. The ... [more ▼]

The high resolution which can be obtained by computer-assisted x-ray tomography is used to investigate Various scale heterogeneities of the flow texture characterizing multiphase flow in packed beds. The direct counting of 'irrigated' pixels allows the determination of the number of individual liquid rivulets as well as their size. The evolution of the liquid flow texture versus the liquid velocity agrees quite well with the predictions of a percolation-based model. This agreement is further confirmed by the comparison of the experimental hold-up values averaged over the column cross-section with the theoretical model. [less ▲]

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See detailSuperconductivity fluctuation effects on the thermal conductivity of Bi2Sr2CaCu2O8
Houssa, M.; Bougrine, Hassan ULg; Stassen, S. et al

in Physical Review. B : Condensed Matter (1996), 54(10), 6885-6888

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional ... [more ▼]

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional (2D) to 3D behavior theoretically predicted by Varlamov and Livanov is well marked. The crossover temperature T-VL and the amplitude of the fluctuation contribution lead to realistic values for the interlayer coupling energy J(C) and the transport relaxation time tau near T-c. [less ▲]

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See detailThe frequency of cutaneous vasculitis is not increased in patients with rheumatoid arthritis treated with methotrexate
Kaye, O.; Beckers, C. C.; Paquet, P. et al

in Journal of Rheumatology (1996), 23(2), 253-257

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well ... [more ▼]

OBJECTIVE: To analyse the frequency, type, and immunohistological features of clinical cutaneous vasculitis developing in patients with rheumatoid arthritis (RA) treated or not with methotrexate as well as their demographic, clinical and biological characteristics. METHODS: Ninety-one patients with RA receiving 9.5 mg/wk of methotrexate (MTX) were compared for an average observation time of 18 months to 130 matched patients with RA treated with various drugs excluding MTX. RESULTS: Whether receiving MTX or not, 5.4% of patients with RA developed a clinical cutaneous vasculitis. There were significant differences between both groups for 2 variables only: a higher percentage of polyneuropathies and a higher level of immune complex-plasma levels in non-MTX patients. The immunohistological analysis did not differentiate both groups. CONCLUSION: The percentage of cutaneous vasculitis that developed under MTX therapy was not different from that occurring as a natural complication of longstanding severe RA. [less ▲]

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See detailL’expérience du SEGEFA en géographie appliquée
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (1996), (19), 25-29

Presentation and critical analysis of the experience in applied geography SEGEF

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See detailHacia una cartografía del boom. Una polémica en Zona Franca (ag.-dic.1972).
Vanden Berghe, Kristine ULg

in América. Cahiers du CRICCAL (1996), 15/16

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See detailHydrodynamic simulations of galaxy formation .2. Photoionization and the formation of low-mass galaxies
Thoul, Anne ULg; Weinberg, D. H.

in Astrophysical Journal (1996), 465(2), 608-616

Photoionization by the high-redshift ultraviolet radiation background heats low- density gas before it falls into dark matter potential wells, and it eliminates the neutral hydrogen and singly ionized ... [more ▼]

Photoionization by the high-redshift ultraviolet radiation background heats low- density gas before it falls into dark matter potential wells, and it eliminates the neutral hydrogen and singly ionized helium that dominate cooling of primordial gas at temperatures of 10(4)-10(5) K. We investigate the influence of photoionization on galaxy formation using high-resolution simulations with a one-dimensional, spherically symmetric, Lagrangian hydrodynamics/gravity code. We find that the presence of a photoionizing background suppresses the formation of galaxies with circular velocities v(circ) less than or similar to 30 km s(-1) and substantially reduces the mass of cooled baryons in systems with circular velocities up to v(circ) similar to 50 km s(-1). Above v(circ) similar to 75 km s(-1), photoionization has no significant effect. Photoionization exerts its influence primarily by heating gas before collapse; the elimination of line cooling processes is less important. We discuss the implications of these results for hierarchical theories of galaxy formation. [less ▲]

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See detailSequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
Goffin, VINCENT; Shiverick, KATHLEEN T; Kelly, PAUL A et al

in Endocrine Reviews (1996), 17(4), 385-410

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See detailIntérêt de l'acide rétinoïque "tous trans" dans le traitement de la leucémie aiguë promyélocytaire
Hermanne, J.-P.; Tassin, F.; Bours, Vincent ULg et al

in Médecine et Hygiène (1996), 54

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See detailEvaluation of the cranial rectus abdominus muscle pedicle flap as a blood supply for the caudal superficial epigastric skin flaps in dogs.
Degner, Daniel; Walshaw, Richard; Arnoczky, Steven et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1996), 25

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See detailInfluence of the production of two lipopeptides, Iturin A and Surfactin S1, on oxygen transfer during Bacillus subtilis fermentation
Hbid, Choukri; Jacques, Philippe; Razafindralambo, Hary ULg et al

in Applied Biochemistry and Biotechnology (1996), 57-8

Bacillus subtilis produces three types of lipopeptides: Iturins, Fengycins, and Surfactins. These amphiphilic molecules influence the volumetric oxygen transfer (K(L)a) like chemical surfactant. K(L)a ... [more ▼]

Bacillus subtilis produces three types of lipopeptides: Iturins, Fengycins, and Surfactins. These amphiphilic molecules influence the volumetric oxygen transfer (K(L)a) like chemical surfactant. K(L)a values were from two- to fivefold lower when both Iturin A and Surfactin S1 were coproduced, and from 0.57- to 0.8-fold lower when only Iturin A was produced. The addition of an oxygen vector (n-Dodecane) during fermentation increased K(L)a values (7.5-fold) and biomass production (twofold), and decreased Iturin A and Surfactin S1 production. However, at high stirring conditions and in the presence of n-Dodecane, Iturin A production was improved. [less ▲]

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See detailBrain hypometabolism of glucose in anorexia nervosa: Normalization after weight gain
Delvenne, Véronique; Goldman, Serge; De Maertelaer, Viviane et al

in Biological Psychiatry (1996), 40(8), 761-768

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex ... [more ▼]

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex-matched healthy volunteers were used as controls. Both groups were scanned during rest, eyes closed and with low ambient noise. In absolute values, the underweight anorectic patients, when compared to control subjects, showed a global (p = 0.002) and regional (p ≤ 0.001) hypometabolism of glucose which normalized with weight gain. In relative values, no global difference could be assessed between underweight anorectic patients and controls but a trend can, nevertheless, be observed toward parietal and superior frontal cortex hypometabolism associated with a relative hypermetabolism in the caudate nuclei and in the inferior frontal cortex. After weight gain, all regions normalized for absolute and relative values, although a trend appears toward relative parietal hypometabolism and inferior frontal cortex hypermetabolism in weight gain anorectic patients. Absolute brain glucose hypometabolism might result from neuroendocrinological or morphological aspects of anorexia nervosa or might be the expression of altered neurotransmission following deficient nutritional state. As some differences exists in relative values in underweight patients and tend to persist in weight gain states, this could support a potential abnormal cerebral functioning, a different reaction to starvation within several regions of the brain or different restoration rates according to the region. [less ▲]

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See detailHistological and biometrical study of intraovarian oocytes in barbel (Barbus barbus) reared in captivity
Poncin, Pascal ULg; Thiry, Marc ULg; Lepoint, A. et al

in Folia Zoologica (1996), 45(Suppl. 1), 117-

In the present study, we investigated the histology and oocyte size variations in ovaries from barbel reared in captivity. We demonstrated that the size distribution of intraovarian oocytes is quadrimodal ... [more ▼]

In the present study, we investigated the histology and oocyte size variations in ovaries from barbel reared in captivity. We demonstrated that the size distribution of intraovarian oocytes is quadrimodal (including primary oocytes, oocytes with vacuoles, vitellogenetic oocytes and ova), Indicating that oocyte development can be found in the ovaries (some oocytes are in late vitellogenesis). The ovarian structure is discussed in realation to the repeated spawnings observed in captivity. [less ▲]

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See detailPostencephalitic stereotyped involuntary movements responsive to L-Dopa
Picard, F.; deSaintMartin, A.; Salmon, Eric ULg et al

in Movement Disorders (1996), 11(5), 567-570

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few ... [more ▼]

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L-Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L-Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra. [less ▲]

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See detailA new HPLC method for the assay of alkaloids in Strychnos nux-vomica and Strychnos ignatii
Gadi Biala, Rose; Tits, Monique ULg; Wauters, Jean-Noël ULg et al

in Fitoterapia (1996), 67(2), 163-165

A reversed-phase high performance liquid chromatographic procedure was developed for the qualitative and quantitative analysis of the alkaloids in S. nux-vomica and S. ignatii.

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See detailNeurophysins in central diabetes insipidus
Legros, Jean-Jacques ULg; Geenen, Vincent ULg

in Hormone Research (1996), 45

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See detailVaricella-zoster virus : a cause of waxing and waning vasculitis. The New England Journal of Medicine case 5-1995 revisited
Gilden, D. H.; Kleinschmidt-DeMasters, B. K.; Wellish, M. et al

in Neurology (1996), 47(6), 1441-1446

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal ... [more ▼]

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal of Medicine.(1) We restudied the pathologic material and found both varicella tester virus (VZV) DNA and VZV-specific antigen, but not herpes simplex virus (HSV) or cytomegalovirus (CMV) DNA or HSV- or CMV-specific antigen, in three of the five cerebral arteries examined. The inflammatory response, disruption of the internal elastic lamina, and detection of viral antigen were patchy from one artery to another, as well as within a given artery. A search for VZV should be conducted in cases of vasculitis when both the central and peripheral nervous systems are involved, when focal narrowing is present in large arteries, when brain imaging reveals infarction in gray and white matter, both deep and superficial, and when white matter is disproportionally involved. Zosteriform rash is not required for diagnosis. [less ▲]

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See detailEtude des groupements de macrophytes vasculaires aquatiques de la Semois en rapport avec la qualité globale des eaux et du milieu
Thoen, Daniel ULg; Roussel, Laurence; Nicolas, Jacques ULg

in Ecologie (1996), 27(4), 223-232

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements ... [more ▼]

Les groupements de macrophytes aquatiques de la Semois (ca. 200 km de long) ont été décrits par l'analyse de 218 relevés de végétation réalisés durant l'année 1994. De l'amont vers l'aval, six groupements végétaux ont été caractérisés. Deux zones principales peuvent être distinguées. Dans la zone amont, la végétation potentielle a été détruite ou remplacée par des groupements végétaux, plus résistants à la pollution organique et aux modifications physiques du milieu: groupement à Sparganium emersum et Potamogeton nanans; association à Potamogeton pectinatus. Dans la zone aval, la présence de groupements relevant du Ranunculetum fluitantis est plus conforme à la végétation potentielle et indique de meilleures conditions du milieu. Une analyse canonique des correspondances, sur les principales espèces aquatiques et les paramètres physico-chimiques de l'eau de 40 stations, a permis de regrouper des espèces présentant des affinités écologiques entre elles et de dégager leurs valeurs indicatrices relatives pour certains paramètres abiotiques. [less ▲]

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See detailTaqi Growth Hormone Gene Polymorphism And Milk Production Traits In Holstein-Friesian Cattle
Falaki, M.; Sneyers, M.; Prandi, A. et al

in Animal Science (1996), 63

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See detailCloning and Sequencing of the Dnak Locus in Streptomyces Coelicolor A3(2)
Brans, Alain ULg; Loriaux, Axelle; Joris, Bernard ULg et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1996), 6(3), 179-84

The dnaK operon of Streptomyces coelicolor A3(2) was cloned by the DNA-probing method using synthetic oligonucleotides designed on the basis of two of the most conserved regions in 30 different DnaK ... [more ▼]

The dnaK operon of Streptomyces coelicolor A3(2) was cloned by the DNA-probing method using synthetic oligonucleotides designed on the basis of two of the most conserved regions in 30 different DnaK proteins (HSP70). The isolated insert-a BamHI 5.6-kb fragment-was sequenced and shown to contain three open-reading frames organized in an operon and coding for proteins analogous to DnaK, GrpE and DnaJ, successively. [less ▲]

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See detailAutologous stem cell transplantations in elderly AML patients
Archimbaud, E.; Jehn, U.; De Cataldo, F. et al

in Trends in Onco-Hematology (1996), 4(2), 28-29

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See detailWhat about lorisk Figo Stage Ia and Ib, G1-G2 endometrial adenocarcinoma ?
Delaloye, J-F; Megalo; COUCKE, Philippe ULg et al

in Radiotherapy & Oncology (1996), 43(Supp 1), 6

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See detailA propos de la genèse des orthostates néo-assyriens
Tunca, Önhan ULg

in Tablettes et images aux pays de Sumer et d'Akkad. Mélanges offerts à Monsieur H. Limet (A.P.H.A.O. Mémoires n° 1) (1996)

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See detailVardaman's Fish and Addie's Jar: Faulkner's Tales of Mourning and Desire
Delville, Michel ULg

in HJEAS, Hungarian Journal of English and American Studies (1996)

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See detailPrognostic Significance of bcl-2 Protein Expression in Aggressive Non-Hodkin's Lymphoma
Hermine, Olivier; Haioun, Corinne; Lepage, Eric et al

in Blood (1996)

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailModulation of expression and assembly of vinculin during in vitro fibrillar collagen-induced angiogenesis and its reversal.
Deroanne, Christophe ULg; Colige, Alain ULg; Nusgens, Betty ULg et al

in Experimental Cell Research (1996), 224(2), 215-23

A model of collagen-induced in vitro angiogenesis was used to investigate the modulation of expression and assembly of focal adhesion plaque-associated proteins during the process of differentiation ... [more ▼]

A model of collagen-induced in vitro angiogenesis was used to investigate the modulation of expression and assembly of focal adhesion plaque-associated proteins during the process of differentiation. Human umbilical vein endothelial cells (HUVEC), first attached on an adhesive substratum (gelatin-, fibronectin-, or laminin-coated dish) or adherent collagen gel and then covered by an overlaying collagen get, organized within 3-4 days in tube-like structures (TLS). Removing the overlaying collagen gel from fully differentiated HUVEC induced a reversion of the process and HUVEC returned to a monolayer pattern. Modulations of focal adhesion-associated proteins occurring in HUVEC during the in vitro differentiation process and its reversal were investigated by Western blot analysis. A significant decrease of expression of vinculin, the integrin alpha2 subunit, talin, alpha-actinin, and actin was observed in TLS whereas the amount of FVIII-related antigen did not vary as compared to control monolayer cultures. During reversal, all the reduced proteins were markedly reexpressed. Human skin fibroblasts (HSF), submitted to the same experimental conditions, did not form TLS. Most of the focal adhesion proteins in HSF were similarly modulated by an overlaying collagen gel with the exception of vinculin, which was not modified. This particular protein was therefore more thoroughly investigated. In a nondifferentiated monolayer of HUVEC, a significant proportion of vinculin was organized into a detergent-resistant juxtamembranous structure (focal adhesion plaque) which disassembled early in TLS formation and reassembled during the reversal of the process. The reduction of vinculin during TLS formation was preceded by a downregulation of its mRNA while this mRNA was upregulated during reversal of the morphotype. These results suggest that the modulations of the cytoskeletal and focal adhesion proteins and more specifically of vinculin coupled to its subcellular redistribution are critical and early events in the cascade of mechanochemical signaling during in vitro angiogenesis induced by fibrillar collagen. [less ▲]

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See detailLe frêne, un bois noble et précieux
Claessens, Hugues ULg

in Forêt Wallonne (1996), 28

Avec le bouleau, l'aulne glutineux, les tilleuls, les érables, le merisier et d'autres feuillus relativement marginaux dans le marché du bois, le frêne fait partie des espèces secondaires de la forêt ... [more ▼]

Avec le bouleau, l'aulne glutineux, les tilleuls, les érables, le merisier et d'autres feuillus relativement marginaux dans le marché du bois, le frêne fait partie des espèces secondaires de la forêt wallonne, qui, ensemble ne représentent que 7% du volume sur pied, alors qu'à eux seuls, le hêtre, les chênes et l'épicéa en totalisent 85% (données IFW). Certaines, comme le frêne, sont qualifiées de "nobles" ou encore de "précieuses" en raison de leur valeur marchande (frêne, érable et merisier). Une des causes de ce phénomène est le choix délibéré des propriétaires forestiers, qui, pour des raisons que nous connaissons, à la fois historiques et liées aux marchés du bois passé et actuel, ont préféré le hêtre, le chêne et l'épicéa, souvent sous forme de monoculture, réduisant ainsi l'espace qui revenait naturellement aux espèces secondaires, naturellement disséminées dans nos forêts. [less ▲]

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See detailParadoxical Sleep Deprivation Increases the Content of Glutamate and Glutamine in Rat Cerebral Cortex
Bettendorff, Lucien ULg; Sallanon-Moulin, M.; Touret, Monique et al

in Sleep (1996), 19(1), 65-71

We investigated the influence of the sleep/waking cycle, the effects of paradoxical sleep deprivation (PSD) and of the vigilance-promoting drug modafinil on the amino acid contents of rat brain cortex. No ... [more ▼]

We investigated the influence of the sleep/waking cycle, the effects of paradoxical sleep deprivation (PSD) and of the vigilance-promoting drug modafinil on the amino acid contents of rat brain cortex. No significant nycthemeral variations in amino acid levels could be detected. PSD (12-24 hours), using the water tank method, significantly increased the levels of glutamate and glutamine. The increase was still observed after the sleep rebound period. gamma-Aminobutyric acid (GABA) levels did not change significantly during the instrumental sleep deprivation but increased during the rebound period. Control experiments indicate that the increase in glutamate and glutamine levels is due to PSD rather than to the stress associated with the experimental procedure. The increase in glutamate content cannot arise only from transamination reactions, because the levels of other amino acids (such as aspartate) did not decrease. Modafinil treatment did not significantly modify the brain cortex content of any of the amino acids tested. [less ▲]

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See detailCardiovascular involvement during HIV infection.
Valdes, E. F.; Fernandez, R. E.; Villanueva, H. R. et al

in European Heart Journal (1996), 17(10), 1605

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See detailGlucose, alpha-amino nitrogen and amino acid exchange across the hindlimb in young bulls maintained at two growth rates
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Gauthier, Sabine et al

in Canadian Journal of Animal Science (1996), 76(2), 193-202

The effect of growth rate and protein supplementation on muscle metabolism of eight bulls from the Belgian Blue breed, double-muscled type, was investigated by the arterio-venous difference technique. A ... [more ▼]

The effect of growth rate and protein supplementation on muscle metabolism of eight bulls from the Belgian Blue breed, double-muscled type, was investigated by the arterio-venous difference technique. A low growth (LG) group was maintained at a low growth rate over 36 d, and a rapid growth (RG) group for 28 d before receiving a fattening diet allowing for a rapid growth. At the end of the RG period the RG bulls received a supplement of protected soybean meal. Animals were fitted with an aortic ultrasonic blood flow probe and with catheters in the aorta and the vena cava. The blood flow in the hindlimbs of bulls varied greatly by time of the day but was higher in the RG group. The RG group had a higher arterio-venous difference (AVD) and uptake of alpha-amino nitrogen while AVD in essential amino acids was four times higher and uptake eight times higher. Significant higher AVD or uptake was observed in individual amino acids such as leucine, isoleucine and lysine. The supplementation with protected soybean meal had significant negative effect on the uptake of several amino acids. It was concluded that caution should be exercised when measuring punctually blood flow in muscle tissue, for example by dilution techniques. At high growth rate, the requirements for amino acids are larger than for glucose. Excess protein provides no additional benefit. [less ▲]

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See detailBacteriogical evidence of leptospira infetion in wild mammals from Azores archipelago, Portugal (short report)
Collares Pereira, Margarida; Santos Reis, Margarida; Oom, Maria do Mar et al

in Vie et milieu (1996), 46(3-4), 380-381

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See detailMicrosatellite mapping of a major determinant of White Heifer Disease: the bovine roan locus
Charlier, Carole ULg; Denys, B.; Belanche, J. I. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1996), 7

In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r + (black) and R (white ... [more ▼]

In the Belgian Blue Cattle breed, coat color variation is mainly under the influence of a single autosomal locus, the roan locus, characterized by a pair of codominant alleles: r + (black) and R (white). Heterozygous r + R animals have intermingled black and white hairs, yielding the ``blue'' phenotype typical of the breed. Major interest for the roan locus stems from its pleiotropic effect on fertility, owing to the critical role of the R allele in the determinism of White Heifer Disease. We describe the linkage mapping of the roan locus to bovine Chromosome (Chr) 5, in the interval between microsatellite markers BPI and AGLA293, with an associated lodscore of 11.2. Moreover, we map a candidate gene, the Steel locus coding for the mast cell growth factor, to bovine Chr 5. [less ▲]

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See detailRecherches sur le Paléolithique supérieur de la Moldavie
Otte, Marcel ULg; López Bayón, Ignacio; Noiret, Pierre ULg et al

in Anthropologica et Praehistorica : Bulletin de la Société Royale Belge d'Anthropologie et de Préhistoire (1996), 107

The Moldavian sequence is an illustration of all the phases of the Upper Palaeolithic. It starts with archaic industries (with bifacial foliate points), then is going on with local Aurignacian industries ... [more ▼]

The Moldavian sequence is an illustration of all the phases of the Upper Palaeolithic. It starts with archaic industries (with bifacial foliate points), then is going on with local Aurignacian industries, and finally show a very intensive development of Gravettian industries. Its geographical position gives it a key-position for the study of the relationships between the hills of Central Europe and the wide eastern plains. [less ▲]

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See detailAvoided resonance overlapping beyond the energy independent formalism. II. Electronic predissociation
Brems, Vincent; Desouter, Michèle ULg; Liévin, Jacques

in Journal of Chemical Physics (1996), 104

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See detailTomographie a emission de positons dans l'evaluation de l'extension ganglionnaire intrathoracique du cancer bronchique non petites cellules. Etude preliminaire chez 30 patients.
Bury, Thierry ULg; CORHAY, Jean-Louis ULg; Paulus, P et al

in Revue des Maladies Respiratoires (1996), 13(3), 281-286

Current methods for evaluating the mediastinum include chest radiography, computed tomography (CT) or magnetic resonance (MR) imaging and mediastinoscopy. Despite advances in morphologic imaging, some ... [more ▼]

Current methods for evaluating the mediastinum include chest radiography, computed tomography (CT) or magnetic resonance (MR) imaging and mediastinoscopy. Despite advances in morphologic imaging, some lung cancer patients are found to have unresectable disease at surgery. In contrast to CT scan or MR imaging, which depend primarily on anatomic and morphological criteria, positron emission tomography (PET) with 18fluorodeoxyglucose (FDG) depends mainly of the metabolic characteristics of a tissue for the diagnosis of disease. We perform a prospective study to compare FDG-PET and CT of the thorax in the presurgical assessment of the mediastinum in patients with newly diagnosed non-small cell lung cancer. Thirty patients have been included. CT and PET-scans were interpreted separately and results were compared to surgical staging during thoracotomy. In assessing mediastinal involvement, CT scan had a sensitivity of 56% and a specificity of 64%. For diagnosis mediastinal nodal disease, FDG-PET was 87% sensitive and 78% specific. Its positive predictive value was 82%, and the negative value was 83%. In conclusion, our preliminary results show that FDG-PET appears more accurate than CT in staging of mediastinal non-small cell lung cancer. [less ▲]

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See detailGaston Leroux et la dissociation de la matière romanesque
Denis, Benoît ULg

in Tapis-franc. Revue du roman populaire (1996), (7), 56-66

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See detailSelection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA.
Hendrix, Chris; Anne, J; Joris, Bernard ULg et al

in Biochemical Journal (1996), 314 ( Pt 2)

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was ... [more ▼]

Four GUC triplets in the coding region of the MRNA of interleukin 6 (IL-6) were examined for their suitabilty to serve as a target for hammerhead ribozome-mediated cleavage. This selection procedure was performed with the intention to downregulate IL-6 production as a potential treatment of those diseases in which IL-6 overexpression is involved. Hammerhead ribozymes and their respective short synthetic substrates (19-mers) were synthesized for these four GUC triplets. Notwithstanding the identical catalytic core sequences, the difference in base composition of the helices involved in substrate binding caused substantial variation in cleavage activity. The cleavage reactions on the 1035 nucleotide IL-6 mRNA transcript revealed that two ribozymes were able to cleave this substrate, showing a decrease in catalytic efficiency to 1/30 and 1/300 of the short substrate. This study indicates that the GUC triplet located at nucleotide 510 of the mRNA of IL-6 is the best site for hammerhead ribozyme-mediated cleavage. We suggest that in future targeting of chemically modified hammerhead ribosomes for cleavage of IL-6 RNA should be directed at this location. [less ▲]

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See detailLe Maître et son hypertexte
Vromans, Joseph ULg

in Etudes & Travaux (1996), I

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See detailLa traversée des candiatures universitaires : Une analyse de cas
Beckers, Jacqueline ULg; Boxus, Elise ULg

in Res Academica (1996), 13(1-2), 85-104

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See detailProbabilities for forbidden transitions in atoms and ions: 1989-1995. A commented bibliography
Biémont, Emile ULg; Zeippen, C. J.

in Physica Scripta (1996), T65

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See detailLa classification numérique : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (1), 28

The principles of some clustering techniques are described and illustrated by an example. The data consist of chemical contents for 45 types of mineral water.

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See detailEtude de la fiabilité d'un nouvel analyseur de lactate portable chez le cheval
Meynie, J.; Art, Tatiana ULg; Olaerts, J. et al

in Pratique Vétérinaire Equine (1996), 28(1), 37-40

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples ... [more ▼]

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples were obtained and analyzed either with the portable analyzer or with a reference method. The packed cell volume has been also determined for each sample. The results obtained with both methods were compared : the correlation between the two sets of data was satisfactory ((R2 = 0,86) but higher when the PCV was lower or equal to 55 % (R2 = 0,88). It was concluded that the portable analyzer is reliable for lactate determination in horses [less ▲]

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See detailDéplacements prémigratoire et itinéraire de migration d'une cigogne noire (Cicinia nigra) juvénile suivie par télémétrie satellitaire
Libois, Roland ULg; Jadoul, Gérard

in Aves (1996), 33(1), 1-10

On 19th of July 1995, a juvenile black stork was caught in the vicinity of Bastogne (Province of Luxembourg, Belgium) and was fitted a PTT platform weighing about 75 grams. The locations obtained by the ... [more ▼]

On 19th of July 1995, a juvenile black stork was caught in the vicinity of Bastogne (Province of Luxembourg, Belgium) and was fitted a PTT platform weighing about 75 grams. The locations obtained by the Argos system were sorted according to their precision and the fixes of good quality (A,0,2 or 3 in the Argos classification) were mapped. From the 19th July to the first migration day (28 August at 09h GMT), more than fifty percent of the 109 obtained fixes are located inside a zone of 100 km² (5.65 km radius) centered near the capture point. Moreover, that zone bas been visited nearly every day by the bird. Twenty more percent of the fixes are situated in a wider area of 300 km² (9.77 km radius). That region is covered by spruce plantations, deciduous forests and cattle meadows with numerous small watercourses and several ponds including fish ponds. Some medium distance (10 to 110 km apart from the home range centre) movements were also recorded, mainly eastwards and westwards. No difference has been evidenced in the home range use during the 4 decades of monitoring. The migration travel was monitored till the 06th September, when the transmitter failed due to a technical misconception. At that time, the stork was located in the region of Fès (Morocco). Within 9 days, the bird has travelled a distance of ca 2,400 km (mean daily movement: 237 km). The Pyrenees were crossed in the high valley of the river Tech (Pyrénées Orientales, France) only 3 days after the departure and the bird has been seen by Spanish colleagues when flying across the strait of Gibraltar (Tarifa, 5 September, 07.55 h GMT). [less ▲]

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See detailProbing the Surface Molecular Structure in the UPS Spectra of Octadecanethiol and 1-Cyclohexyl-12-dodecanethiol Self-Assembled on Gold
Duwez, Anne-Sophie ULg; Riga, Joseph; Han, Bo-Ying et al

in Journal of Electron Spectroscopy & Related Phenomena (1996), 81

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See detailEvolution chronologique des précipitations dans le Sud-Est du Zaïre. Comparaison avec celle des pays voisins
Kalombo, K.; Erpicum, Michel ULg; Assani, A.

in Publications de l'Association Internationale de Climatologie (1996), 9

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See detailEtat-providence et efficacité économique
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Revue Française d'Economie (1996), XI, 2(Printemps), 29-44

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See detailLes xenika et les barbarika onomata dans les théories linguistiques gréco-latines
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1996), 65

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See detailActualités thérapeutiques dans la thrombocytémie essentielle
Hermanne, J.-P.; Tassin, F.; Beguin, Yves ULg et al

in Médecine et Hygiène (1996), 54

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of ... [more ▼]

Essential thrombocythemia is a myeloproliferative disorder affecting megakaryocyte and is characterized by frequent thrombotic or hemorrhagic complications. In young patients, the optimal management of thrombocythaemia is controversial. Since th relationship of thrombosis and hemorrhage to platelet counts is not demonstrated, ther is no clear inidcation for using drugs capable of lowering platelet counts in young asymptomatic subjects. However, treatment should be offered to patients with a definite high risk of major or life-threatening hemostatic complications. The present paper reviews the incidence and risk factors for thrombotic complications and the use of medications inhibiting platelet production. [less ▲]

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See detailAu fur et à mesure qu'elles se construisent, les trajectoires professionnelles divergent entre les sexes : l'exemple belge
Gavray, Claire ULg

in Formation Emploi : Revue Française de Sciences Sociales (1996), 93

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See detailT92-0045: Interlaboratory quality control on Tpot measurements
Coucke, Philippe ULg; Beer, K.; Bernier, J. et al

in International Journal of Radiation, Oncology, Biology, Physics (1996), 36(1(supp1)), 384

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See detailPrécarité psycho-sociale différentielle des hommes et des femmes
Born, Michel ULg; Gavray, Claire ULg

in Cahiers de l'IPSA (1996), 19

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See detailPrimary Systemic Amyloidosis - A report of 2 cases
Dezfoulian, Bita ULg; Arrese Estrada, Jorge ULg; Fernandez, A. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1996), 192

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection ... [more ▼]

We report 2 cases of primary systemic amyloidosis. A monoclonal gammopathy was confirmed at the postmortem examination of the first patient. An extensive search for evidence of chronic infection, inflammation, neoplasms and paraproteinemia was conclusively negative in the other patient. The recognition of cutaneous signs of primary systemic amyloidosis is crucial to insure a rapid management aimed at postponing the fatal issue of the disease. [less ▲]

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See detailIn vitro activity of amoxycillin/clavulanate and ticarcillin/clavulanate compared with that of other antibiotics against anaerobic bacteria: comparison with the results of the 1987 survey
Pierard, denis; De Meyer A; Rosseel, P. et al

in Acta Clinica Belgica (1996), 51(2), 70-9

The activity of amoxycillin/clavulanate (Augmentin) and ticarcillin/ clavulanate (Timentin) was tested against 351 strict anaerobic clinical isolates collected from September 1993 to April 1994 in eight ... [more ▼]

The activity of amoxycillin/clavulanate (Augmentin) and ticarcillin/ clavulanate (Timentin) was tested against 351 strict anaerobic clinical isolates collected from September 1993 to April 1994 in eight Belgian university hospitals and compared with that of 8 other antibiotics using the NCCLS reference agar dilution procedure. Production of beta-lactamase was detected by the nitrocefin test in 48% of the isolates. At NCCLS-recommended breakpoints, more than 90% of isolates were susceptible to amoxycillin/clavulanate, ticarcillin/clavulanate, piperacillin/tazobactam, imipenem, chloramphenicol and metronidazole but only 77%, 72% and 48% to cefoxitin, clindamycin and penicillin, respectively. In comparison with the results of a similar survey conducted in 1987 no major changes in susceptibility were observed except for the susceptibility to clindamycin that declined from 83% to 72% overall, and from 83% to 66% in the B. fragilis group. Furthermore one isolate of Clostridium clostridioforme was found produce beta-lactamase and few B. fragilis group isolates showed reduced susceptibility to metronidazole. [less ▲]

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See detailIn situ demonstration of germinal cell apoptosis during diethylstilbestrol-induced testis regression in adult male syrian hamsters
Nonclercq, D.; Reverse, D.; Toubeau, G. et al

in Biology of Reproduction (1996), 55(6), 1368-1376

Testis regression was induced in male Syrian hamsters by chronic exposure to diethylstilbestrol (DES), an estradiol-1713 agonist. Experimental groups (n = 4-5) were killed at increasing time intervals ... [more ▼]

Testis regression was induced in male Syrian hamsters by chronic exposure to diethylstilbestrol (DES), an estradiol-1713 agonist. Experimental groups (n = 4-5) were killed at increasing time intervals over a period of 6 mo after initiation of treatment. Apoptosis in testes was demonstrated by in situ analysis of DNA fragmentation. Cell proliferation was monitored by immunostaining nuclei of S-phase cells after pulse labeling with 5-bromo-2'-deoxyuridine. Levels of FSH and testosterone, measured by RIA, fell rapidly in DES-treated hamsters. In parallel, testis weight and seminiferous tubule area underwent an 80% decrease during the first 2 wk of DES administration. The composition of seminiferous epithelium was also drastically affected by DES, since it became progressively confined to Sertoli cells, spermatogonia, and spermatocytes. Testis regression was associated with an important increase of apoptosis, which started 3 days after the beginning of DES administration. Apoptosis was still 10- to 50-fold higher than in control testes by the end of treatment; it affected primarily spermatocytes and, to a much lesser extent, spermatogonia. Cell proliferation was not inhibited by chronic DES administration. In conclusion, these data indicate that apoptosis can by itself account for estrogen-induced testis regression. [less ▲]

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See detailA double-blind, three-week study to compare the efficacy and safety of meloxicam 7.5 mg and meloxicam 15 mg in patients with rheumatoid arthritis.
REGINSTER, Jean-Yves ULg; Distel, M.; Bluhmki, E.

in British Journal of Rheumatology (1996), 35(Suppl 1), 17-21

A multicentre, double-blind, randomized study was conducted in patients with rheumatoid arthritis (RA) in order to compare the efficacy and safety of two different doses of meloxicam, a new preferential ... [more ▼]

A multicentre, double-blind, randomized study was conducted in patients with rheumatoid arthritis (RA) in order to compare the efficacy and safety of two different doses of meloxicam, a new preferential cyclooxygenase-2 (COX-2) inhibitor. Four hundred and twenty-three patients were randomized to receive once-daily oral meloxicam 7.5 mg (n = 216) or meloxicam 15 mg (n = 207) for 3 weeks. The Ritchie joint index and pain in the morning were significantly improved versus baseline (P < 0.001) in both groups. There were no significant differences between the effects of each dose with respect to these measures nor with respect to final assessment of global efficacy by the patients. However, the 15 mg dose was associated with a significantly (P < 0.05) better effect on morning stiffness and grip strength. No differences between the doses were observed with regard to the other secondary efficacy parameter (pain at night, body weight and erythrocyte sedimentation rate). Both doses of meloxicam were well tolerated. There were no differences between the doses with respect to global tolerance as assessed by the patient and the patients, 'general condition'. In conclusion, meloxicam at a once-daily dose of either 7.5 or 15 mg is well tolerated and effective in the treatment of patients with RA. [less ▲]

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See detailCuba in tijden van periodo especial
Vanden Berghe, Kristine ULg

in Romaneske (1996), 21(1), 40-44

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See detailThermographic facial pattern following an alpha2-adrenergic agonist injection in two horses suffering from Horner's syndrome
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Education (1996), 8(4), 192-195

The objective of the present study was to confirm this latter assumption, by measuring the facial skin temperature by infrared thermography after administration of an alpha2-adrenergic agonist to horses ... [more ▼]

The objective of the present study was to confirm this latter assumption, by measuring the facial skin temperature by infrared thermography after administration of an alpha2-adrenergic agonist to horses suffering from HS. [less ▲]

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See detailCartes de contrôle : combinaison de résultats, données corrélées ou multivariées
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (3), 1-37

This note first describes moving average, exponentially weighted moving average and cumulative sum control charts. Then, control charts for autocorrelated and for multivariate data are examined. Minitab ... [more ▼]

This note first describes moving average, exponentially weighted moving average and cumulative sum control charts. Then, control charts for autocorrelated and for multivariate data are examined. Minitab outputs are given for these control charts. [less ▲]

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See detailEthnic Mobilisation, Multiculturalism and the Political Process in two Belgian Cities : Antwerp and Liège
Martiniello, Marco ULg; Blommaert, Jan

in Innovation in Social Sciences Research (1996), 9(1), 51-74

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See detailCartes de contrôle : les cartes de Shewhart.
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1996), (2), 41

This note describes the SHEWHART control charts for subgroup means, standard deviation, medians, ranges, proportions of defectives, numbers of defectives and numbers of defects. Minitab and SAS outputs ... [more ▼]

This note describes the SHEWHART control charts for subgroup means, standard deviation, medians, ranges, proportions of defectives, numbers of defectives and numbers of defects. Minitab and SAS outputs are given for all these charts. [less ▲]

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See detailDescription des plantules de quatre Caesalpiniacées africaines
Léonard, J.; Doucet, Jean-Louis ULg

in Bulletin du Jardin Botanique National de Belgique = Bulletin van de Nationale Plantentuin van België (1996), 66

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See detailDéveloppement d'un modèle de type arbre appliqué à la croissance des peuplements feuillus irréguliers du sud de la Belgique
Lejeune, Philippe ULg

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (1996), 26(10), 1838-1848

A model predicting circumference growth of individual trees has been developed for mixed irregular stands dominated by Fagus silvatica L. in southeastern Belgium. This model integrates simultaneously tree ... [more ▼]

A model predicting circumference growth of individual trees has been developed for mixed irregular stands dominated by Fagus silvatica L. in southeastern Belgium. This model integrates simultaneously tree, stand, and growing site characteristics without considering distances between individual trees. It has a determination coefficent of 40.1 % and a residual standard deviation of 0.45cm/year. Forest mensuration variables considered in the model are circumference, tree social position represented by the total basal area of trees greater than the subject tree, stand basal area, and some index of stand structure corresponding to the ratio of the variance over the mean circumference. The site component is essentially expressed by the length of the growing period. The low accuracy obtained for individual tree growth is relative because the results are used mainly after individual trees have been distributed into size classes. We have been able to show that the introduction of crown description in the model can increase its accuracy. But this modification requires a submodel describing crown changes over time. [less ▲]

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See detailBiodegradable and macroporous polylactide implants for cell transplantation : 1. Preparation of macroporous polylactide supports by solid-liquid phase separation
Schugens, Ch; Maquet, Véronique; Grandfils, Christian ULg et al

in Polymer (1996), 37(6), 1027-1038

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing ... [more ▼]

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing and formulation parameters. The effects of polymer concentration, chain stereoregularity, polymer molecular weight and cooling rate have been investigated in connection with the porous morphology and the physico-mechanical characteristics of the final foams. As a rule, bundles of channels are formed with a diameter of ~100 μ.m. They have a preferential orientation that fits the cooling direction. A porous substructure (~10 μm) is observed in the internal walls of the tubular macropores. Variations in this general porous morphology-and particularly in the porosity, density, solvent residue, mechanical resistance and degree of regularity in the spatial organization of pores-have been observed when polymer concentration in 1,4-dioxane and polylactide stereoregularity are changed. As expected, cooling rate has a strong effect on the foam morphology, which is essentially controlled by the solvent crystallization. Pores are nothing but the fingerprints of 1,4-dioxane crystallites. [less ▲]

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See detailUne approche heuristique de l'analyse.
Hauchart, C.; Schneider, Marguerite ULg

in Repères IREM (1996), 25

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See detailRheumatic and musculoskeletal diseases and impaired quality of life. A challenge for rheumatologists
Morales-Torres, J; Reginster, Jean-Yves ULg; Hochberg, MC

in Journal of Rheumatology (1996), 23

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See detailDe la patria potestas (puissance paternelle) à l'autorité parentale
Gerkens, Jean-François ULg

in L'enfant, avenir des droits de l'homme (1996)

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See detailRéactions physiologiques face à des conditions extrêmes de chaleur et d'humidité relative. Etude de la récupération après l'exercice
Art, Tatiana ULg; Votion, Dominique ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (1996), 28

The purpose of this study was to follow the recovery of horses during 1hour after treadmill exercise performed either in temperated atmospheric conditions (TC) (ambient temperature: 15°C; relative ... [more ▼]

The purpose of this study was to follow the recovery of horses during 1hour after treadmill exercise performed either in temperated atmospheric conditions (TC) (ambient temperature: 15°C; relative humidity: 55%) or in hot and humid conditions (HHC) (ambient temperature: 30°C; relative humidity: 75%). Five healthy fit standardbred horses (493± 14 kg; 4± 0,5 yrs) were investigated twice at eight days interval, in TC and in HHC. Some ventilatory and cardiorespiratory measurements were made during a standardised treadmill exercise test (SET), other measurements, i.e. cardiac and respiratory frequencies and rectal temperature, during a 1-hour recovery period. The SET consisted in 8 min warm-up and in 8 min exercise (1 min at 1,7, 4, 7, 8, 9 and 10 m/sec and 2 min at 4 m/sec with a 6% (3.4°) slope). Venous blond was sampled before, 2 min, 60 min and 48 hours after the completion of the test for biochemical analysis, namely plasma electrolytes and enzymatic activities. Exercising in HHC induced a reduction of the aerobic metabolism to the total energy requierement, i.e. a 20 % decrease of VO, and 55 % increase in lactate, as well as a decrease in VE. The increase in rectal and skip temperature, the dehydration and the weight loss were higher in HHC than in TC. During the recovery period the HR and f remained higher up to 30 minutes after the end of the SET in HHC while the rectal temperature remained higher up to 60 min after the end of this test. Sa, despite the fact that our horses recovered in TC after exercising in HHC, there were significant differences between their physiological parameters measured during the recovery. This means that the recovery in air-conditionned unit would probably be an insufficient measure to ensure an adequate cooling of the horses and justify consequently the adaptations proposed by the FEI, i.e. the decrease of the distance of the run and the increase of the lime devoted to the hall between phases [less ▲]

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See detailInfluence of Van Hove singularity on the electronic specific heat of high-Tc superconductors
Dorbolo, Stéphane ULg; Houssa, Michel; Ausloos, Marcel ULg

in Physica C: Superconductivity (1996)

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See detailGuidelines for authors of medical scientific manuscripts.
Detry, Olivier ULg; Van Damme, Hendrik ULg; Van de Stadt, J.

in Acta Chirurgica Belgica (1996), 96(4), 140-3

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See detailSensitivity calculations and variance analysis in plant measurement reconciliation
Heyen, Georges ULg; Marechal, Eric; Kalitventzeff, Boris ULg

in Computers & Chemical Engineering (1996), 20(Suppl. A), 539-544

Analysis of the results of a data reconciliation program is made easier by extracting more information from the Jacobian matrix of the constraint equations. Standard deviation for all state variables ... [more ▼]

Analysis of the results of a data reconciliation program is made easier by extracting more information from the Jacobian matrix of the constraint equations. Standard deviation for all state variables (measured or not measured) is related to the standard deviation of measurements. Distinction between variables that are actually corrected by the validation process, and those that are merely derived from a single measurement is straightforward. Based on this information, decisions can be taken : deletion of unnecessary measurements, addition of new measurement points and their optimal selection, or identification of key measurements for which any enhancement of accuracy would result in significant improvement in the quality of the process validation. [less ▲]

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See detailConditional heteroskedasticity adjusted market model and an event study
Corhay, Albert ULg; Tourani-Rad, Alireza

in Quarterly Review of Economics and Finance (1996), 36(4), 529-538

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See detailLessons from the discovery of leptin: is obesity an endocrine disease?
Scheen, André ULg

in Acta Clinica Belgica (1996), 51(6), 371-6

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See detailExhaustion of blood glucose response and enhancement of insulin response after repeated glucagon injections in type-2 diabetes: potentiation by progressive hyperglycemia.
Castillo, M. J.; Scheen, André ULg; Paolisso, G. et al

in Annales d'Endocrinologie (1996), 57(5), 395-402

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients ... [more ▼]

AIMS: To investigate the hyperglycemic and insulinemic response to repeated glucagon injections in Type-2 (non-insulin-dependent) diabetic patients. METHODS: In overnight fasted Type-2 diabetic patients, three i.v. glucagon (1 mg) injections were given as a bolus at two-hour intervals. In the hour preceding each glucagon injection, 6 patients received saline and they were tested at near-baseline blood glucose levels, while 8 patients received a glucose-controlled glucose infusion and they were tested at increasing blood glucose levels (7.5 +/- 0.2, 12.9 +/- 0.5 and 18.7 +/- 0.7 mmol/l). Blood samples were collected at 0, 3, 5, 10, 15, 30 and 60 min after each glucagon injection. RESULTS: In the patients tested at near-baseline blood glucose levels, the blood glucose rise induced by glucagon was smaller after repeated injections. By contrast, the B-cell response to glucagon was well preserved. In the patients tested at increasing blood glucose levels, the blood glucose response to glucagon was abolished after repeated injections. By contrast, the B-cell response was significantly potentiated. The respective areas under the curve of plasma insulin levels in response to glucagon were 563 +/- 72, 1047 +/- 154 and 1844 +/- 305 m U x 30 min/l (p < 0.001). CONCLUSION: In Type-2 (non-insulin-dependent) diabetic patients, repeated glucagon injections, even when administered in a short (4 h) period of time, do not exhaust the B-cell. Endogenous insulin secretion is even potentiated at increasing blood glucose levels. By contrast, the hyperglycemic response to glucagon is significantly abolished, particularly at high blood glucose levels. [less ▲]

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See detailCost effectiveness of treatment in osteoporosis
Reginster, Jean-Yves ULg

in Journal of Rheumatology (1996), 23(7), 1312-1313

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See detailIs IL-6 capable to modify chondrocyte metabolism ?
Henrotin, Yves ULg; Labasse, A; Jaspar, JM et al

in Clinical Rheumatology (1996), 15

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See detailEvaluation du rôle préventif des oestroprogestatifs et des thérapeutiques non hormonales dans le cadre de l'ostéoporose postménopausique
Reginster, Jean-Yves ULg

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1996), 25(7), 677-83

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of ... [more ▼]

Osteoporosis is a medical, social and economical problem for developed countries. Prevention remains the only realistic approach to reduce the burden related to this disorder. Primary prevention of osteoporosis is based on efforts to reach a maximal peak bone mass at the end of the growth period and, subsequently, at the time of menopause. No pharmacological intervention is considered at this stage. Biologically, hormone replacement therapy induces a correction of the biochemical changes observed in markers of bone remodeling at the time of the menopause. A systematic screening of asymptomatic postmenopausal women followed by the induction of hormonal replacement therapy in high risk subjects appears to be an interesting cost/benefit strategy in terms of reasonable attribution of health resources. Nasal administration of calcitonin fully prevents the trabecular bone loss observed during the first years of menopause. Notwithstanding, the exact dose of nasal calcitonin able to prevent bone loss remains to be fully elucidated. Bisphosphonates inhibit bone resorption. Tiludronate prevents trabecular postmenopausal bone loss. The use of selectif estrogen receptor modulators is based on a possible differential action of these molecules, at the level of the estrogenic receptors, depending of the tissue considered. Several direct inhibitors of osteoclastic resorption are also under development. Their main target is either to prevent the linkage of osteoclasts to the bone matrix or to prevent the acidification of bone matrix required to induce the resorption process. [less ▲]

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See detailA Morphometric and Functional Study of the Toxicity of Atmospheric Ammonia in the Extrathoracic Airways in Pigs
Urbain, B.; Gustin, Pascal ULg; Charlier, G. et al

in Veterinary Research Communications (1996), 20(4), 381-399

The effects of atmospheric ammonia (NH3) on the nasal and tracheal mucosa of pigs were investigated by morphometric and functional methods. Pigs were exposed to four concentrations of NH3 [5 (control), 25 ... [more ▼]

The effects of atmospheric ammonia (NH3) on the nasal and tracheal mucosa of pigs were investigated by morphometric and functional methods. Pigs were exposed to four concentrations of NH3 [5 (control), 25, 50 and 100 ppm] for 6 days in a specially designed air-pollutant exposure chamber. Samples were taken from the turbinates and the trachea, and the respiratory mucosa was examined by light and scanning electron microscopy. Dose-response curves to carbachol and isoproterenol were constructed using isolated strips of tracheal smooth muscle, with or without epithelium. In pigs exposed to ammonia, considerable mucosal injuries were observed in the turbinates but not in the trachea. The number of neutrophils in the epithelial layer and in the lamina propria, and epithelial hyperplasia were closely and significantly correlated with the concentrations of ammonia (r = 0.894, p < 0.001; r = 0.727, P < 0.001; and r = 0.818, p < 0.001, respectively). Except for the lamina propria, all these changes were significant (p < 0.05) at ammonia concentrations as low as 25 ppm. The percentage of the surface of the turbinate mucosa that was ciliated tended to decrease with increasing ammonia concentration (r = 0.439, p < 0.082). Ammonia induced smooth-muscle hyperresponsiveness to carbachol with a close linear correlation between individual values of the carbachol-induced maximal effect and the NH3 concentrations (r = 0.526, p < 0.003). While mechanical destruction of the epithelium induced an increase in Emax in the control group, no difference was observed between the intact and denuded strips from animals exposed to ammonia. The response to isoproterenol was not influenced by ammonia. It was concluded that quantitative histological analysis of the inflammatory infiltration and epithelial hyperplasia in the turbinates is a useful tool for quantifying the effects of atmospheric pollutants in pigs; a 6-day exposure to ammonia induces nasal irritation and functional disturbances of the tracheal smooth-muscle contractions at concentrations as low as 25 ppm [less ▲]

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See detailDensité osseuse fémorale et carence vitaminique D dans une population de femmes âgées
DEROISY; Pirenne, H; FREDERICK, Isabelle ULg et al

in Archives of Public Health (1996), 53(S1), 37

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See detailBrain Levels of Thiamine and Its Phosphate Esters in Friedreich's Ataxia and Spinocerebellar Ataxia Type 1
Bettendorff, Lucien ULg; Mastrogiacomo, Frank; LaMarche, J. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (1996), 11(4), 437-439

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we ... [more ▼]

Decreased blood and cerebrospinal fluid levels of thiamine have been reported in patients with spinocerebellar ataxia disorders. To determine whether a thiamine deficiency is present in the brain, we measured levels of thiamine and its phosphate esters thiamine monophosphate (TMP) and thiamine diphosphate (TDP), in postmortem cerebellar and cerebral cortices of patients with Friedreich's ataxia (FA) and spinocerebellar ataxia type 1 (SCA1). Brain levels of free (nonphosphorylated) thiamine, TMP, TDP, and total thiamine in FA and SCA1 were, on average, not significantly different from control values. However, a nonsignificant trend was observed for slightly reduced levels of TDP and total thiamine in cerebellar cortex of the SCA1 patients, a finding that might be related to the severe neuronal damage in this brain area. We conclude that in FA, brain thiamine concentrations are normal, whereas in SCA1 the levels are, at most, only slightly reduced. [less ▲]

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See detailThe human 37kDa laminin receptor precursor/p40 ribosomal associated protein multigene family : structure of the active gene and chromosomal location at 3p21.3
Jackers, Pascale ULg; Minoletti, Fabiola; Belotti, Dorina et al

in Cell Biology International (1996), 20

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See detail9-Methoxygeissoschizol, an alkaloid from bark of strychnos guianensis
Mavar-Manga, Hélène; Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg et al

in Phytochemistry (1996), 43(5), 1125-1127

The isolation and structure determination of 9-methoxygeissoschizol from the stem bark of Strychnos guianensis is described. Elucidation of its structure is mainly based on NMR studies.

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See detailLes constructions analogiques du futur III
Winand, Jean ULg

in Revue d'Egyptologie (1996), 47

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See detailCytokine gene polymorphisms in inflammatory bowel disease.
Louis, Edouard ULg; Satsangi, J.; Roussomoustakaki, M. et al

in Gut (1996), 39(5), 705-10

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The number and identity of ... [more ▼]

BACKGROUND: Concordance rates in siblings and twins provide strong evidence that genetic susceptibility is important in the pathogenesis of inflammatory bowel disease. The number and identity of susceptibility genes is largely uncertain. Cytokine genes are attractive candidate loci. AIMS: To study allelic frequencies of polymorphisms of the interleukin-1 receptor antagonist (IL-1RA) gene and the tumour necrosis factor alpha gene in patients with inflammatory bowel disease. SUBJECTS: One hundred and twenty nine North European caucasoid patients with ulcerative colitis, 120 patients with Crohn's disease, and 89 healthy controls. METHODS: Genotyping was performed by polymerase chain reaction. A variable number of tandem repeats (VNTR) in the IL-1RA gene and a single base pair polymorphism in the TNF alpha gene promoter region (TNF-308) were analysed. RESULTS: No significant differences in IL-1RA VNTR allelic frequencies were noted between Crohn's disease (allele 1: 72.6%, allele 2: 24.7%, allele 3: 2.6%), ulcerative colitis (72.6%, 24.3%, 3.1%, respectively), and controls (76.9%, 20.8% and 2.3%). Some 42.4% of patients with ulcerative colitis and 43.4% patients with Crohn's disease were carriers of allele 2, compared with 34.8% healthy subjects. The TNF2 allele was modestly reduced in Crohn's disease (13.2%), compared with healthy subjects (21.3%; p = 0.04), and ulcerative colitis (21.6%). CONCLUSIONS: The associations demonstrated are modest: these polymorphisms are unlikely to be important determinants of overall disease susceptibility. [less ▲]

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