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See detailThe faint young sun climatic paradox: A simulation with an interactive seasonal climate-sea ice model
Gérard, Jean-Claude ULg; Hauglustaine, Didier A.; François, Louis ULg

in Global and Planetary Change (1992), 97(3), 133-150

A seasonal one-and-a-half-dimensional (1 1/2-D) energy-balance climate model including a detailed sea ice calculation and an interactive albedo formulation has been developed and is used to investigate ... [more ▼]

A seasonal one-and-a-half-dimensional (1 1/2-D) energy-balance climate model including a detailed sea ice calculation and an interactive albedo formulation has been developed and is used to investigate the faint young sun climatic paradox. This model is shown to reproduce the present climate and sea ice observations. In spite of its greater complexity, its behavior is globally similar to simple energy-balance models with highly parameterized ice-albedo feedback used in previous studies of this question. It is found that when the solar luminosity drops by more than about 5% below its present value, the ice albedo feedback causes a global irreversible glaciation. Several sensitivity experiments show that the value of the critical solar constant and associated global surface temperature are only little sensitive to the set of model parameters describing the ice and snow albedo and meridional heat transport. In contrast, the absence or polar location of the continental mass introduce a nearly 10% decrease of the critical luminosity. The minimum level of atmospheric CO2 needed to prevent a global glaciation through enhanced greenhouse warming is calculated as a function of the solar luminosity. A 30% drop in solar output requires a 2 x 10(4)-fold increase in atmospheric CO2, an unacceptably large value. However, in the absence of continents, a carbon dioxide partial pressure of 2000 times the present level is found to be sufficient to stabilize the climate. The effects of a reduced continental area, paleogeographic changes and higher CO2 greenhouse effect combine to ensure a larger stability of the non-frozen configuration. Their cumulated and interactive effects may be able to solve the young sun paradox. [less ▲]

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See detailDétermination en mode maillé du champ d’intervisibilité dans un modèle numérique de terrain
Donnay, Jean-Paul ULg

in Cartographica (1992), 29(3-4), 75-82

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See detailEmperipolesis of lymphoid cells by human follicular dendritic cells in vitro.
Tsunoda, R.; Nakayama, M.; Heinen, Ernst ULg et al

in Virchows Archiv. B : Cell pathology (1992), 62(2), 69-78

Isolated follicular dendritic cells (FDCs) showed true and pseudoemperipolesis of fresh tonsillar lymphocytes, even after long-term (50-day) cultivation. Emperipolesis by FDCs was not restricted by ... [more ▼]

Isolated follicular dendritic cells (FDCs) showed true and pseudoemperipolesis of fresh tonsillar lymphocytes, even after long-term (50-day) cultivation. Emperipolesis by FDCs was not restricted by allotype specificity, nor was it inhibited by the addition of antibodies against MHC-I & II antigens. Follicular dendritic cells predominantly engulfed B-cells; monocytes and macrophages were not found between FDC cytoplasmic extensions. When highly purified T-cell populations were added to FDC cultures emperipolesis of T-cells occurred, particularly those of the CD4-positive phenotype. Mitoses appeared within 6 h in the emperipolesed lymphocytes and, after an additional 18 h, some lymphocytes exhibited apoptosis. [less ▲]

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See detailThe 19-27 Amino-Acid Segment Of Gp51 Adopts An Amphiphilic Structure And Plays A Key Role In The Fusion Events Induced By Bovine Leukemia-Virus
Voneche, V.; Callebaut, I.; Kettmann, Richard ULg et al

in Journal of Biological Chemistry (1992), 267(21),

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S ... [more ▼]

Previous results indicate that the external glycoprotein gp51 of bovine leukemia virus plays an important role in the process of cell fusion induced by bovine leukemia virus (Bruck, C., Mathot, S., Portetelle, D., Berte, C., Franssen, J. D., Herion, P., and Burny, A. (1982) Virology 122, 342-352; Voneche, V., Portetelle., D., Kettmann, R., Willems, L., Limbach, K., Paoletti, E., Ruysschaert, J. M., Burny, A., and Brasseur, R. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 3810-3814) and suggest that a region encompassing residues 23 and 25 of gp51 is involved in this process (Portetelle, D., Couez, D., Bruck, C., Kettmann, R., Mammerickx, M., Van der Maaten, M., Brasseur, R., and Burny, A. (1989) Virology 169, 27-33; Mamoun, R., Morisson, M., Rebeyrotte, N., Busetta, B., Couez, D., Kettmann, R., Hospital, M., and Guillemain, B. (1990) J. Virol. 64, 4180-4188). X-ray diffraction studies performed on envelope glycoproteins of influenza virus indicate that the NH2-terminal part of the external glycoprotein lies very close to the fusion peptide. The same overall structure seems to exist in human immunodeficiency virus as suggested by site-directed mutagenesis followed by syncytia induction assays. Our theoretical studies indicate that a segment expanding between residues 19 and 27 of gp51 probably adopts an amphipathic beta-strand structure. We hypothesize that the amphipathic 19-27 structure of gp51 plays an important role in the process of membrane fusion by interacting with the fusion peptide or with another region of gp30. Mutational analysis disrupting the amphipathy of the 19-27 region strongly altered the fusogenic capacity of the gp51-gp30 complex. [less ▲]

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See detailLe mot et les rites. Un aperçu des significations de ὄργια et de quelques dérivés
Pirenne-Delforge, Vinciane ULg; Motte, André ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1992), 5

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See detailL'analyse causale au service de l'éducation nutritionnelle: l'exemple du "petit déjeuner malin".
Guillaume, Michèle ULg; Lambrecht, B.; Andrien, M. et al

in Rev Education Santé (1992)

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See detailFluoxetine therapy in obese diabetic and glucose intolerant patients.
Kutnowski, M.; Daubresse, J. C.; Friedman, H. et al

in International Journal of Obesity & Related Metabolic Disorders (1992), 16 Suppl 4

A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a ... [more ▼]

A double-blind placebo-controlled trial was conducted, involving 97 obese diabetic and glucose intolerant patients receiving either 60 mg fluoxetine daily (47 patients) or a placebo (50 patients); a similar calorie-restricted diet was prescribed to all patients. Weight loss was significantly higher in the fluoxetine-treated patients, whose diabetic status improved. Drop-out rate was not significantly different for both groups of patients. [less ▲]

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See detailSerum erythropoietin levels during haematinic treatment
Cazzola, M.; Beguin, Yves ULg

in British Journal of Haematology (1992), 82

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See detailMODELING THE PHANEROZOIC CARBON-CYCLE AND CLIMATE - CONSTRAINTS FROM THE SR-87-SR-86 ISOTOPIC RATIO OF SEAWATER
François, Louis ULg; WALKER, J. C. G.

in American Journal of Science (1992), 292(2), 81-135

A numerical model describing the coupled evolution of the biogeochemical cycles of carbon, sulfur, calcium, magnesium, phosphorus, and strontium has been developed to describe the long-term changes of ... [more ▼]

A numerical model describing the coupled evolution of the biogeochemical cycles of carbon, sulfur, calcium, magnesium, phosphorus, and strontium has been developed to describe the long-term changes of atmospheric carbon dioxide and climate during the Phanerozoic. The emphasis is on the effects of coupling the cycles of carbon and strontium. Various interpretations of the observed Phanerozoic history of the seawater Sr-87/Sr-86 ratio are investigated with the model. More specifically, the abilities of continental weathering, volcanism, and surface lithology in generating that signal are tested and compared. It is suggested that the observed fluctuations are mostly due to a changing weatherability over time. It is shown that such a conclusion is very important for the modelling of the carbon cycle. Indeed, it implies that the conventional belief that the evolution of atmospheric carbon dioxide and climate on a long time scale is governed by the balance between the volcanic input of CO2 and the rate of silicate weathering is not true. Rather carbon exchanges between the mantle and the exogenic system are likely to have played a kev role too. Further, the increase of the global weathering rates with increasing surface temperature and/or atmospheric CO2 pressure usually postulated in long-term carbon cycle and climate modelling is also inconsistent with the new model. Other factors appear to have modulated the weatherability of the continents through time, such as mountain building and the existence of glaciers and ice sheets. Based on these observations, a history of atmospheric carbon dioxide and climate during Phanerozoic time, consistent with the strontium isotopic data, is reconstructed with the model and is shown to be compatible with paleoclimatic indicators, such as the timing of glaciation and the estimates of Cretaceous paleotemperatures. [less ▲]

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See detailObservations sur l'utilisation de traitements gonadotropes répétés chez la chèvre laitière
Baril, Gérard; Remy, Benoît ULg; Vallet, J. C. et al

in Annales de Zootechnie (1992), 41(3-4), 291-296

Observations on the repeated use of gonadotropin treatments in the dairy goat. Our studies have attempted to determine if the absence of oestrus observed in some goats after fluorogestone acetate-pregnant ... [more ▼]

Observations on the repeated use of gonadotropin treatments in the dairy goat. Our studies have attempted to determine if the absence of oestrus observed in some goats after fluorogestone acetate-pregnant mare serum gonadotropin (FGA-PMSG) treatments could be due to its repeated use. An experiment was carried out in a Saanen flock, in which she-goats were submitted to FGA-PMSG treatment each year. The first treatment of the year was performed on 169 shegoats between March and August 1989. Of the females diagnosed as non-pregnant following the first treatment, 38 were treated a second time during the same period. The proportion of females which went into oestrus after the first treatment was lower in 59 multiparous goats than in 64 nulliparous and in 46 primiparous goats (64.4 vs 100 and 97.8%; P < O.Oi). For the she-goats treated twice, the percentage of females which went into oestrus after the second treatment was lower than that observed after the first treatment (44.7 vs 71.0%; P < 0.05). The presence of anti-PMSG antibodies in plasma was investigated in blood samples taken before and after each treatment. Results are expressed as % of radioactive PMSG bound by 10 pl of blood plasma. Before the first treatment, the percentage of bound PMSG was higher in multiparous than in nulliparous and primiparous goats (17.5 t 23.1 vs -0.06 t 0.7 ; 1.2 ± 1.9 ; P < 0.01), and increased after treatment for all parities. In goats treated twice, the percentage of bound PMSG before the second treatment was higher than that observed before first treatment (22.8 t 23. vs 11.2 f 19.7; P < 0.05). For both treatments, females which did not come into oestrus showed a percentage of bound PMSG which was significantly higher than that of goats in which oestrus was observed (multiparous first treatment: 30.5 f 23.6 vs 1I 2. 9 20. 1 %; she-goats in second treatment: 33.9 ± 23.1 vs 9.2 ± 14.5T.). When the percentage of bound PMSG before treatment was low (< 5°l) in multiparous goats, the oestrus and kidding rates after the first treatment did not differ from those observed in nulliparous and primiparous goats. The decrease in the efficiency of the treatments was therefore not due to the age of animals. The repeated use of FGA-PMSG during the lifetime of goats or within the same year is followed by an increase in the levels of antibodies against PMSG. The presence of those antibodies may explain the decrease in the efficiency of these treatments in inducing and synchronizing oestrus. [less ▲]

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See detailEffect of bilateral stimulation on spinal evoked potentials in dogs
Poncelet, Luc; Delauche, A.; Vinals, C. et al

in American Journal of Veterinary Research (1992)

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See detailEtude de l'efficacité du Valtran® gouttes chez des patients atteints de lombarthrose
WANG, François-Charles ULg; Franchimont, Paul

in Medical Trends (1992)

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See detailCombined 10pter-->P11 and 18pter-->Q11 Trisomy in a 7-Year-Old Child
Lapiere, J. C.; Verloes, Alain ULg; Herens, Christian ULg et al

in Genetic Counseling (Geneva, Switzerland) (1992), 3(3), 155-9

We report a severely mentally retarded, dysmorphic girl aged 7 years with a 47,XX, +der(18), t(10;18)(p11.2;q11.2)mat. The phenotype of our patient is compared with 6 cases of trisomy 10p and 10 cases of ... [more ▼]

We report a severely mentally retarded, dysmorphic girl aged 7 years with a 47,XX, +der(18), t(10;18)(p11.2;q11.2)mat. The phenotype of our patient is compared with 6 cases of trisomy 10p and 10 cases of trisomy 18q- from the literature. The short trisomic segment 10pter-10p11 appears to affect more the phenotype than the trisomic segment 18qter-q11. [less ▲]

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See detailEvaluation of in Vitro Reconstituted Basement Membrane Assay to Assess the Invasiveness of Tumor Cells
Simon, N.; Noël, Agnès ULg; Foidart, Jean-Michel ULg

in Invasion & Metastasis (1992), 12(3-4), 156-67

The crossing of tumor cells through basement membranes represents a critical step in the metastatic process. We have used a reconstituted basement membrane (matrigel) coated on filter in a Boyden chamber ... [more ▼]

The crossing of tumor cells through basement membranes represents a critical step in the metastatic process. We have used a reconstituted basement membrane (matrigel) coated on filter in a Boyden chamber to assess the invasive potential of tumor and normal cells. No correlation was found between chemoinvasion in vitro and the metastatic potential in vivo. Normal human fibroblasts and murine 3T3 fibroblasts penetrated filters coated with matrigel. On the other hand, the tumoral cells (MCF7, MCF7 gpt, MCF7 ras, BeWo, JAR, NUC-1 cells) were unable to cross the matrix. Our results suggest that in our conditions, this widely used model to assess tumoral invasion does not provide a universal assay to test the invasiveness of tumor cells. Penetration of the matrigel appears to be related to chemotactic or haptotactic responses depending upon cell types. Our data emphasize the variability of molecular events associated with basement membrane invasion. [less ▲]

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See detailVers un apprentissage semi-autonome en français langue de spécialité (première partie)
Vanden Berghe, Kristine ULg; Slootmakers, An; Sanctobin, Véronique et al

in Romaneske (1992), 17(2), 2-30

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See detailSupplementation Of Pressed Sugar-Beet Pulp Silage With Molasses And Urea, Laying Hen Excreta Or Soybean-Meal In Ruminant Nutrition
Leterme, Pascal; Thewis, André ULg; Culot, Marc ULg

in Animal Feed Science & Technology (1992), 39(3-4), 43-55

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See detailStructure of the tilapia (Oreochromis mossambicus) prolactin I gene
Swennen, D.; Poncelet, A. C.; Sekkali, B. et al

in DNA & Cell Biology (1992), 11(9), 673-84

The tilapia (Oreochromis mossambicus) prolactin-I (PRL-I) gene has been cloned and sequenced. Its transcript (3,677 bases long) begins with a guanine and is organized in five exons and four introns like ... [more ▼]

The tilapia (Oreochromis mossambicus) prolactin-I (PRL-I) gene has been cloned and sequenced. Its transcript (3,677 bases long) begins with a guanine and is organized in five exons and four introns like the other known prolactin genes. Analysis of the 1,555-bp 5'-flanking region suggests that pituitary-specific expression of the gene could be regulated through a trans-factor related to the mammalian pituitary-specific factor Pit-1. Two potential binding sites for such a factor were found in the first intron, suggesting a possible regulatory role for this region. Moreover, two potential Z-DNA regions are located at positions -837 to -812 and -246 to -179 from the transcription start site. These two regions could play an important role in the regulation of PRL gene expression. [less ▲]

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See detailEnvironmental monitoring at FUL
De Backer, Louis W.; Andre, Philippe ULg; Nicolas, Jacques ULg

in Journal on automatic control (1992), 33

The paper presents the research and teaching activities of Fondation Universitaire Luxembourgeoise (Arlon) and more particularly in the domain of Environmental Monitoring. Particular attention is given to ... [more ▼]

The paper presents the research and teaching activities of Fondation Universitaire Luxembourgeoise (Arlon) and more particularly in the domain of Environmental Monitoring. Particular attention is given to "intelligent measurement, bio-sensors and event forecast algorithms. The team of researchers tries to integrate the three steps of monitoring: measurement, data processing and decision making support. It develops short-term fog forecasting tools, water quality sensors, soil water status quality assessment techniques and uses models describing soil and water transfers in soils and artificial intelligence techniques applied to energy management in buildings. [less ▲]

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See detailLe bâtiment solaire passif de la Fondation Universitaire Luxembourgeoise à Arlon
Andre, Philippe ULg; Nicolas, Jacques ULg; Boreux, Jean-Jacques ULg et al

in Chaleur et climats (1992), (635), 2-8

Description des différentes technologies solaires passives: systèmes à gain direct, murs de masse et serres, mises en oeuvre lors de l'extension de la FUL. Présentation du bilan des performances de ca ... [more ▼]

Description des différentes technologies solaires passives: systèmes à gain direct, murs de masse et serres, mises en oeuvre lors de l'extension de la FUL. Présentation du bilan des performances de ca bâtiment basé sur deux années complètes de mesures intensives [less ▲]

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See detailPour une dramaturgie du Miracle d'Amis et Amille
Henrard, Nadine ULg

in Moyen français (1992), 30

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See detailGrowth Factor Interactions in Cultures of Dissociated Adult Acoustic Ganglia: Neuronotrophic Effects
Lefebvre, P. P.; Van de Water, T. R.; Weber, T. et al

in Brain Research (1991), 567(2), 306-12

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor ... [more ▼]

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor (bFGF). Nerve growth factor (NGF) is not a survival factor for these neurons in vitro, but when used in combination with substrate bound bFGF, NGF does vigorously stimulate a neuritogenesis response by these neurons. Transforming growth factor beta (TGF beta 1) enhances the survival effect that bFGF has on these adult auditory neurons but does not by itself promote their survival in dissociated acoustic ganglion cultures. We propose that there may be complex interactions and synergy exerted by these growth factors (i.e. bFGF, NGF, TGF beta 1) during injury to the inner ear. [less ▲]

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See detailUnusual solar halos over La Silla
Hutsemekers, Damien ULg

in The Messenger (1991), 66

Not Available

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See detailDiscovery of the first eclipsing binary barium star
Jorissen, A.; Manfroid, Jean ULg; Sterken, C.

in The Messenger (1991), 66

Photometric monitoring of barium stars is discussed with particular attention given to the first eclipsing binary barium star, HD 46407. The spectroscopic ephemeris of HD 46407 was used to predict the ... [more ▼]

Photometric monitoring of barium stars is discussed with particular attention given to the first eclipsing binary barium star, HD 46407. The spectroscopic ephemeris of HD 46407 was used to predict the times of a possible eclipse of the companion by the barium star. It is concluded that the light curve of HD 46407 derived from the photometric observations in the D50 system displays a sharp 'primary' eclipse (companion behind the barium star) and a possible shallow 'secondary' eclipse. The primary eclipse occurred in November 1988 and had a depth of about 0.02 mag. [less ▲]

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See detailAnomalous Behaviour of a Protein During Sds/Page Corrected by Chemical Modification of Carboxylic Groups
Matagne, André ULg; Joris, Bernard ULg; Frère, Jean-Marie ULg

in Biochemical Journal (1991), 280((Pt 2)), 553-6

The 29,000-Mr Actinomadura R39 beta-lactamase exhibited a remarkably low electrophoretic mobility on SDS/PAGE, yielding an Mr value almost twice that computed from the corresponding gene sequence. We ... [more ▼]

The 29,000-Mr Actinomadura R39 beta-lactamase exhibited a remarkably low electrophoretic mobility on SDS/PAGE, yielding an Mr value almost twice that computed from the corresponding gene sequence. We showed that chemical modification of the carboxylic groups of glutamic acid and aspartic acid residues restored a normal electrophoretic mobility and that the anomalous behaviour of that protein on SDS/PAGE was due to its very large negative charge at neutral pH. We also compared the behaviour of the same enzyme on gel filtration in the presence of SDS with those of other class A beta-lactamases (Mr approx. 30,000). These experiments suggested that the very low electrophoretic mobility of the Actinomadura R39 beta-lactamase upon SDS/PAGE was more probably due to a low degree of SDS binding rather than to an unusual shape of the SDS-protein complex. [less ▲]

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See detailThe Enterococcus Hirae R40 Penicillin-Binding Protein 5 and the Methicillin-Resistant Staphylococcus Aureus Penicillin-Binding Protein 2' Are Similar
el Kharroubi, Aboubaker; Jacques, Philippe; Piras, Graziella et al

in Biochemical Journal (1991), 280(Pt 2), 463-469

The penicillin-resistant Enterococcus hirae R40 has a typical profile of membrane-bound penicillin-binding proteins (PBPs) except that the 71 kDa PBP5 of low penicillin affinity represents about 50% of ... [more ▼]

The penicillin-resistant Enterococcus hirae R40 has a typical profile of membrane-bound penicillin-binding proteins (PBPs) except that the 71 kDa PBP5 of low penicillin affinity represents about 50% of all the PBPs present. Water-soluble tryptic-digest peptides were selectively produced from PBP5, their N-terminal regions were sequenced and synthetic oligonucleotides were used as primers to generate a 476 bp DNA fragment by polymerase chain reaction. On the basis of these data, the PBP5-encoding gene was cloned in Escherichia coli by using pBR322 as vector. The gene, included in a 7.1 kb insert, had the information for a 678-amino acid-residue protein. PBP5 shows similarity, in the primary structure, with the high-molecular-mass PBPs of class B. In particular, amino acid alignment of the enterococcal PBP5 and the methicillin-resistant staphylococcal PBP2' generates scores that are 30, for the N-terminal domains, and 53, for the C-terminal domains, standard deviations above that expected for a run of 20 randomized pairs of proteins having the same amino acid compositions as the two proteins under consideration. [less ▲]

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See detailJHKLM standard stars in the ESO system
Bouchet, P.; Schmider, F. X.; Manfroid, Jean ULg

in Astronomy and Astrophysics. Supplement Series (1991), 91

A list of 199 standard stars suitable for the ESO standard photometric system at JHKLM is given. Faint stars (although brighter than K = 7.7) to be used on larger telescopes are included. This list is ... [more ▼]

A list of 199 standard stars suitable for the ESO standard photometric system at JHKLM is given. Faint stars (although brighter than K = 7.7) to be used on larger telescopes are included. This list is based on an analysis of all infrared photometric observations carried out at La Silla from 1979 until 1989 inclusive. The accuracy of the data (about 0.02 mag. at J, H, K, L, and M) is similar to the one achieved at SAAO and CTIO. Comparisons with these systems, as well as with the AAO and MSSO systems, are made: it is shown that the ESO system is very close to the other ones, with the exception of CTIOs. [less ▲]

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See detailLe dépistage prénatal de la trisomie 21 sur sérum maternel. Mise au point
Koulischer, Lucien ULg; Schoos, Roland ULg; Verloes, Alain ULg et al

in Revue Médicale de Liège (1991), 46(12), 625-32

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See detailRotational analysis of the a3Πr-X1Σ+ transition of 69Ga35Cl
Mahieu, Emmanuel ULg; DUBOIS, Iwan; BREDOHL, Harald

in Journal of Molecular Spectroscopy (1991), 150(2), 477-485

Six bands (0-0, 0-1, 0-2, 1-0, 2-0, 2-1) of 69Ga35Cl have been fully analyzed for the a-X transition, yielding equilibrium constants for the a3Π, state.

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See detailTestosterone Effects on Staining Density and Autoradiographic Investigations of the Alpha 2-Adrenergic Receptor in the Medial Preoptic Nucleus of the Japanese Quail: Relationship to the Activation of Reproductive Behavior
Balthazart, Jacques ULg; Sante, P.; Ball, G. F.

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1991), 99(6), 385-92

The effects of gonadectomy combined or not with testosterone (T) therapy on the sexual behavior, cloacal gland area, staining density and alpha 2-adrenergic receptors in the medial preoptic nucleus (POM ... [more ▼]

The effects of gonadectomy combined or not with testosterone (T) therapy on the sexual behavior, cloacal gland area, staining density and alpha 2-adrenergic receptors in the medial preoptic nucleus (POM) were studied in male and female Japanese quail. In castrated males, T increased the cloacal gland size and activated copulatory behavior. In agreement with previous reports, these effects were sexually differentiated: under the influence of T, cloacal gland growth was smaller and this treatment did not activate masculine sexual behavior in females. The optical density of the medial preoptic nucleus stained with thionein blue (Nissl stain) was decreased by castration and increased by T in both males and females. This suggests that T has a profound effect on the synthesis of proteins in the POM and, since POM is a critical site in the activation by T of masculine sexual behavior, these induced proteins are, in all probability, a part of the causal chain of biochemical events giving rise to copulatory behavior. The treatment with T had, by contrast, no clear effect on the number of binding sites and on the affinity of the alpha 2-adrenergic receptors in the POM. Therefore, if the noradrenergic transmission is involved in the induction by T of copulatory behavior, it is probably acting either through the alteration of another adrenergic receptor subtype or through the modulation of the baseline levels or turnover of the transmitter itself. [less ▲]

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See detail“Le Sens Propre”. Figures de la défiguration chez Magritte et Camille Goemans
Durand, Pascal ULg

in Correspondance (1991), 2

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See detailDielectric properties of a model cationic ionomer
Yano, S.; Tadano, K.; Jérôme, Robert ULg

in Macromolecules (1991), 24(24), 6439-6442

An alpha,omega-bis(dimethylamino)polyisoprene (M(n)BAR = 5000) has been quaternized by alpha,alpha'-dibromo-p-xylene with formation of a model cationic ionomer. Dielectric spectroscopy has shown an alpha ... [more ▼]

An alpha,omega-bis(dimethylamino)polyisoprene (M(n)BAR = 5000) has been quaternized by alpha,alpha'-dibromo-p-xylene with formation of a model cationic ionomer. Dielectric spectroscopy has shown an alpha-relaxation which corresponds to the micro-Brownian motion of chain segments directly attached to the quaternary ammonium dipoles. A shoulder on the low-temperature side of the alpha-relaxation has been assigned to the contribution of the polymer segments, the mobility of which is not restricted by the multiplets. That situation is in full agreement with the multiplet-cluster concept recently revisited by Eisenberg et al. [less ▲]

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See detailLiving polymerization and selective end functionalization of ε-caprolactone using zinc alkoxides as initiators
Barakat, Ibrahim; Dubois, Philippe; Jérôme, Robert ULg et al

in Macromolecules (1991), 24

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See detailEffect of Calcitonin on Bone Mass and Fracture Rates
Reginster, Jean-Yves ULg

in American Journal of Medicine (1991), 91(5B), 19-22

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See detailA photometric study of the bright cloud B in Sagittarius. VII - 1165 new variable stars and 65 diffuse objects
Terzan, A.; Gosset, Eric ULg

in Astronomy and Astrophysics. Supplement Series (1991), 90

A field in the Sagittarian bright cloud in the direction of the Galactic center is investigated by means of the B, V, and R Schmidt plates at the ESO, and 1165 variable stars are reported. The position, R ... [more ▼]

A field in the Sagittarian bright cloud in the direction of the Galactic center is investigated by means of the B, V, and R Schmidt plates at the ESO, and 1165 variable stars are reported. The position, R magnitudes, epochs, and amplitudes of variation are given for each star, and the surface density per square degree of variable stars increases from 1.7 to 65. The number of variables in the present field is similar to that for field A, and variables of type L and/or M are more densely numerous toward the center of the Galaxy than at other locations. Of the objects listed, 65 are given with potential classifications based on morphological data from the B and R Schmidt plates. The preliminary observations suggest a success rate of 42 percent on the precise prediction of the object types. [less ▲]

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See detailThe nature of the nebula associated with the luminous blue variable star WRA 751
Hutsemekers, Damien ULg; van Drom, E.

in Astronomy and Astrophysics (1991), 251

Narrow-band filter imagery as well as medium to high resolution spectroscopy of the nebula surrounding the luminous blue variable (LBV) star WRA 751 are presented. The nebula appears as a slowly expanding ... [more ▼]

Narrow-band filter imagery as well as medium to high resolution spectroscopy of the nebula surrounding the luminous blue variable (LBV) star WRA 751 are presented. The nebula appears as a slowly expanding H II region of low excitation characterized by a significant N/O overabundance which may be due to the presence in the nebula of nuclear processed material ejected by the star. With the recent discovery of a nebula around HR Car, all but one known galactic LBVs are now shown to be associated with a nebula. These nebula have rather similar physical characteristics, one of the most important being that all of them apparently contain processed material. [less ▲]

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See detailIdentification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase family
Xie, Sancai; Low, Boon G.; Nagel, Robert J. et al

in Proceedings of the National Academy of Sciences of the United States of America (1991), 88(22), 10247-10251

Pregnancy in cattle and sheep can be diagnosed by the presence of a conceptus-derived antigen in maternal serum that is secreted by trophoblast and placental tissue primarily as an acidic component of Mr ... [more ▼]

Pregnancy in cattle and sheep can be diagnosed by the presence of a conceptus-derived antigen in maternal serum that is secreted by trophoblast and placental tissue primarily as an acidic component of Mr 67,000. Molecular cloning of its cDNA reveals that the antigen belongs to the aspartic proteinase family and has greater than 50% amino acid sequence identity to pepsin, cathepsin D, and cathepsin E. The inferred sequences of the ovine and bovine polypeptides show approximately 73% identity to each other. Critical amino acid substitutions at the active site regions suggest that both proteins are enzymatically inactive. The antigen is a product of trophoblast binucleate cells that invade maternal endometrium at implantation sites. [less ▲]

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See detailEffet antalgique du Valtran® dans la polyarthrite rhumatoïde
WANG, François-Charles ULg; Franchimont, Paul

in Medical Trends (1991)

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See detailBovine Herpesvirus 4 Isolates: A Comparison of Three Major Glycoproteins
Dubuisson, J.; Bublot, M.; Wellemans, G. et al

in Veterinary Microbiology (1991), 29(3-4), 251-9

Twenty-four Belgian field isolates of bovine herpesvirus 4 (BHV-4), together with four reference strains were compared by radio-immunoprecipitation and western blotting using a polyvalent antiserum and ... [more ▼]

Twenty-four Belgian field isolates of bovine herpesvirus 4 (BHV-4), together with four reference strains were compared by radio-immunoprecipitation and western blotting using a polyvalent antiserum and monoclonal antibodies raised against major glycoproteins. Most of these strains showed the same protein profile as the European reference strain Movar 33/63. For two strains the molecular weight of gp 6, p (gp 10/gp 17) and gp 10 were the same as those of the American reference strain DN 599. No relationship could be established between the protein profiles and origin of the isolates or with the restriction patterns. This study provides a view of the molecular weight variations of the major BHV-4 glycoproteins among field isolates. [less ▲]

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See detailRésection hépatique ex situ
Honore, Pierre ULg; D'Silva, M.; Meurisse, Michel ULg et al

in Revue Médicale de Liège (1991), 46(11), 602-6

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See detailVoyelles, consonnes et strophes. Une lecture de LXTROHP de Camille Goemans
Durand, Pascal ULg

in Textyles : Revue des Lettres Belges de Langue Française (1991), 8

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See detailComparison of the Sequences of Class a Beta-Lactamases and of the Secondary Structure Elements of Penicillin-Recognizing Proteins
Joris, Bernard ULg; Ledent, P.; Dideberg, O. et al

in Antimicrobial Agents and Chemotherapy (1991), 35(11), 2294-2301

The sequences of class A beta-lactamases were compared. Four main groups of enzymes were distinguished: those from the gram-negative organisms and bacilli and two distinct groups of Streptomyces spp. The ... [more ▼]

The sequences of class A beta-lactamases were compared. Four main groups of enzymes were distinguished: those from the gram-negative organisms and bacilli and two distinct groups of Streptomyces spp. The Staphylococcus aureus PC1 enzyme, although somewhat closer to the enzyme from the Bacillus group, did not belong to any of the groups of beta-lactamases. The similarities between the secondary structure elements of these enzymes and those of the class C beta-lactamases and of the Streptomyces sp. strain R61 DD-peptidase were also analyzed and tentatively extended to the class D beta-lactamases. A unified nomenclature of secondary structure elements is proposed for all the penicillin-recognizing enzymes. [less ▲]

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See detailAltered Response of Progeria Fibroblasts to Epidermal Growth Factor
Colige, Alain ULg; Nusgens, Betty ULg; Lapiere, ChM

in Journal of Cell Science (1991), 100((Pt 3)), 649-55

The Hutchinson-Gilford syndrome (progeria) is a rare disorder in childhood characterized by premature and accelerated aging. This study reports the effect of a potent growth factor, EGF, on the ... [more ▼]

The Hutchinson-Gilford syndrome (progeria) is a rare disorder in childhood characterized by premature and accelerated aging. This study reports the effect of a potent growth factor, EGF, on the proliferative capacities and extracellular matrix macromolecules and collagenase expression of two strains of progeria skin-derived cells. At low population doubling levels (PDL less than 10), confluent cultures of progeria fibroblasts made quiescent by lowering the concentration of serum in the medium did not respond to EGF while the mitotic activity of normal PDL-matched fibroblasts was almost maximally restored upon addition of EGF. No obvious difference between normal and low PDL progeria fibroblasts was observed in the number and in the affinity of the receptors measured by [125I]EGF binding. The synthesis of collagen and non-collagen proteins was similar in normal and affected cells at low and high serum concentration and both types of cells responded to EGF by a specific inhibition of collagen synthesis. Besides a normal level of mRNA coding for type I and type III collagens, collagenase and laminin, progeria fibroblasts expressed a high level of elastin and type IV collagen mRNA. Like normal fibroblasts, progeria cells responded to EGF by a decrease in the level of mRNA for fibrillar collagens and elastin. In contrast, a complete lack of response to EGF was observed for collagenase mRNA whereas the expression of this enzyme was strikingly induced by EGF in normal PDL-matched cells. The abnormal expression of type IV collagen was not significantly modified by EGF. At PDL greater than 10, progeria cells exhibited features of senescence. A significant reduction of collagen synthesis was observed and no further inhibition by EGF was recorded. [less ▲]

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See detailThe photometric variations of the Ap star HD34631
Manfroid, Jean ULg; Renson, Pierre ULg; Catalano, F. A. et al

in Astronomy and Astrophysics. Supplement Series (1991), 90

The photometric behavior in the uvby system of the Ap star HD34631 has been reanalyzed on the basis of data collected over a time span of 16 years. A more accurate value of the period is deduced: P = 2 ... [more ▼]

The photometric behavior in the uvby system of the Ap star HD34631 has been reanalyzed on the basis of data collected over a time span of 16 years. A more accurate value of the period is deduced: P = 2.20269 +/-0.00004d. The lightcurves show a double-wave shape. The variations are smallest in the v band. [less ▲]

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See detailAmino Acid Sequence of the Penicillin-Binding Protein/DD-Peptidase of Streptomyces K15. Predicted Secondary Structures of the Low Mr Penicillin-Binding Proteins of Class A
Palomeque-Messia, Pilar; Englebert, Serge; Leyh-Bouille, Melina et al

in Biochemical Journal (1991), 279(Pt 1), 223-230

The low-Mr penicillin-binding protein (PBP)/DD-transpeptidase of Streptomyces K15 is synthesized in the form of a 291-amino acid-residue precursor possessing a cleavable 29-amino acid-residue signal ... [more ▼]

The low-Mr penicillin-binding protein (PBP)/DD-transpeptidase of Streptomyces K15 is synthesized in the form of a 291-amino acid-residue precursor possessing a cleavable 29-amino acid-residue signal peptide. Sequence-similarity searches and hydrophobic-cluster analysis show that the Streptomyces K15 enzyme, the Escherichia coli PBPs/DD-carboxy-peptidases 5 and 6, the Bacillus subtilis PBP/DD-carboxypeptidase 5 and the spoIIA product (a putative PBP involved in the sporulation of B. subtilis) are structurally related and form a distinct class A of low-Mr PBPs/DD-peptidases. The distribution of the hydrophobic clusters along the amino acid sequences also shows that the Streptomyces K15 PBP, and by extension the other PBPs of class A, have similarity in the polypeptide folding, with the beta-lactamases of class A, with as reference the Streptomyces albus G and Staphylococcus aureus beta-lactamases of known three-dimensional structure. This comparison allows one to predict most of the secondary structures in the PBPs and the amino acid motifs that define the enzyme active sites. [less ▲]

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See detailMechanism of Acyl Transfer by the Class a Serine Beta-Lactamase of Streptomyces Albus G
Lamotte-Brasseur, Josette; Dive, Georges ULg; Dideberg, Otto et al

in Biochemical Journal (1991), 279(Pt 1), 213-221

Optimization by energy minimization of stable complexes occurring along the pathway of hydrolysis of benzylpenicillin and cephalosporin C by the Streptomyces albus G beta-lactamase has highlighted a ... [more ▼]

Optimization by energy minimization of stable complexes occurring along the pathway of hydrolysis of benzylpenicillin and cephalosporin C by the Streptomyces albus G beta-lactamase has highlighted a proton shuttle that may explain the catalytic mechanism of the beta-lactamases of class A. Five residues, S70, S130, N132, T235 and A237, are involved in ligand binding. The gamma-OH group of T235 and, in the case of benzylpenicillin, the gamma-OH group of S130 interact with the carboxylate group, on one side of the ligand molecule. The side-chain NH2 group of N132 and the carbonyl backbone of A237 interact with the exocyclic CONH amide bond, on the other side of the ligand. The backbone NH groups of S70 and A237 polarize the carbonyl group of the scissile beta-lactam amide bond. Four residues, S70, K73, S130 and E166, and two water molecules, W1 and W2, perform hydrolysis of the bound beta-lactam compound. E166, via W1, abstracts the proton from the gamma-OH group of S70. While losing its proton, the O-gamma atom of S70 attacks the carbonyl carbon atom of the beta-lactam ring and, concomitantly, the proton is delivered back to the adjacent nitrogen atom via W2, K73 and S130, thus achieving formation of the acyl-enzyme. Subsequently, E166 abstracts a proton from W1. While losing its proton, W1 attacks the carbonyl carbon atom of the S70 ester-linked acyl-enzyme and, concomitantly, re-entry of a water molecule W'1 replacing W1 allows E166 to deliver the proton back to the same carbonyl carbon atom, thus achieving hydrolysis of the beta-lactam compound and enzyme recovery. The model well explains the differences found in the kcat. values for hydrolysis of benzylpenicillin and cephalosporin C by the Streptomyces albus G beta-lactamase. It also explains the effects caused by site-directed mutagenesis of the Bacillus cereus beta-lactamase I [Gibson, Christensen [less ▲]

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See detailThe Aesthetic of Perception and the Quest for Vision in Faulkner's As I Lay Dying
Delville, Michel ULg

in BELL. Belgian Essays on Language and Literature (1991)

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See detailDetermination of the Expansion Rate and Incidence of Rupture of Abdominal Aortic Aneurysms
Limet, Raymond ULg; Sakalihassan, Natzi ULg; Albert, Adelin ULg

in Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery and International Society For Cardiovascular Surgery, North American Chapter (1991), 14(4), 540-8

Expansion rate and incidence of rupture of abdominal aortic aneurysms in relation to their size is a source of debate. We studied 114 patients (out of a cohort of 752 consecutive patients admitted with ... [more ▼]

Expansion rate and incidence of rupture of abdominal aortic aneurysms in relation to their size is a source of debate. We studied 114 patients (out of a cohort of 752 consecutive patients admitted with abdominal aortic aneurysms) who were denied any immediate operation because of patient's refusal, high surgical risk, or small transverse diameter as assessed by CT scanning and ultrasonography. All patients not operated on underwent from two to six repeated examinations during an average follow-up period of 26.8 months (range, 3 to 132). Forty-seven patients (41.2%) were subsequently operated on electively because of marked increase of transverse diameter of the aneurysm (n = 44) or for other reasons (n = 3), with a death rate of 0%. Eighteen other patients underwent emergency operation for leaking or ruptured aneurysms, and there were five deaths. The incidence of rupture was clearly related to the final diameter value, rising from 0% in aneurysms less than 40 mm to 22% in large size aneurysms (greater than or equal to 50 mm). Among the 49 patients not operated on, one died of rupture before operation and five of causes unrelated to the disease. Using individual serial measurements, we determined the linear expansion rate of the aneurysm, which proved to be related to initial diameter values: 5.3 mm/year for diameters less than 40 mm (n = 49), 6.9 mm/year in the 40 to 49 mm group (n = 41), and 7.4 mm/year for diameters of 50 mm or more (n = 24).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailA technique for multiorgan harvesting in rats--an educational tool in transplantation
D'Silva, Milbhor; Pirenne, Jacques; Bonnet, Pierre ULg et al

in Transplantation Proceedings (1991), 23(5), 2692

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See detailA Mathematical Model of Rinderpest Infection in Cattle Populations
Tille, A.; Lefèvre, Claude; Pastoret, Paul-Pierre ULg et al

in Epidemiology & Infection (1991), 107(2), 441-52

A mathematical model for the epidemiology of rinderpest was developed, starting from a simplified descriptive analysis of the disease. A formula for the calculation of the probability of infection of a ... [more ▼]

A mathematical model for the epidemiology of rinderpest was developed, starting from a simplified descriptive analysis of the disease. A formula for the calculation of the probability of infection of a susceptible animal was first established. A deterministic failure threshold of the infection was then deduced. Deterministic and stochastic approaches were adopted using iterative methods on a computer. These allowed a description of the spread and the variability of an infection process in a population to be made. An illustration of the use of this model showed that, in some cases, variability effects due to stochastic factors were very important. In these particular conditions, the use of the deterministic model alone was not adequate for a good description of the infection. Consequently, improvements of the model were proposed in order to make it more realistic and to allow its use for the evaluation of the efficiency of field operations. [less ▲]

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See detailParvalbumin in the Cardiac Muscle of Normal and Haemoglobin-Myoglobin-Free Antarctic Fish
Laforet, C.; Feller, Georges ULg; Narinx, E. et al

in Journal of Muscle Research and Cell Motility (1991), 12(5), 472-8

Three parvalbumin isotypes were isolated from the white muscle of haemoglobin-myoglobin-free antarctic fish Channichthys rhinoceratus. Antibodies against the parvalbumin mixture were raised in rabbits and ... [more ▼]

Three parvalbumin isotypes were isolated from the white muscle of haemoglobin-myoglobin-free antarctic fish Channichthys rhinoceratus. Antibodies against the parvalbumin mixture were raised in rabbits and used for discovery, quantitation and isolation by affinity chromatography of parvalbumin in the cardiac muscle of three antarctic fish species: Channichthys rhinoceratus, Champsocephalus gunnari and Notothenia neglecta. The cardiac muscle of these species contains parvalbumin in concentration close to 1 mumol per kg wet weight. [less ▲]

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See detailRat Chromosome 5 (Q22-23) Contains Elements That Control Cell Morphology and Interactions with the Extracellular Matrix: A Study of Normal Fibroblast X Malignant Hepatoma Cell Hybrids
Lewalle, J. M.; Szpirer, C.; Szpirer, J. et al

in Experimental Cell Research (1991), 196(2), 164-71

Cell interactions with the extracellular matrix are consistently modified in neoplasia. Malignant transformation has been correlated with modifications in the synthesis and distribution of matrix ... [more ▼]

Cell interactions with the extracellular matrix are consistently modified in neoplasia. Malignant transformation has been correlated with modifications in the synthesis and distribution of matrix components and with alterations of cell adhesive properties to these components. A particular class of genes, able to suppress the transformed phenotype in normal cells, may be involved in those phenotypic changes. By studying somatic cell hybrids between mouse hepatoma (BWTG3) cells and normal rat skin fibroblasts (RSF), Islam and co-workers were able to localize a gene or a group of genes controlling anchorage dependence and cell growth in vitro. This (or these) gene(s) was (were) assigned to the q22-23 fragment of rat chromosome 5. In the present study, we compare the morphology and the interactions with the extracellular matrix proteins (laminin, fibronectin, and collagen IV) and the synthesis of these proteins by RSF X BWTG3 hybrid cells that had either retained (BS181p10) or lost (BS181a5) the q22-23 region of rat chromosome 5. Our results suggest that the rat 5q22-23 fragment controls a part of the cell differentiation program including morphology, attachment to extracellular matrix, and synthesis of some matrix proteins, particularly alpha 1 and alpha 2 chains of collagen IV. [less ▲]

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See detailModelling the Western Mediterranean : from hydrology to hydrodynamics
Beckers, Jean-Marie ULg; Djenidi, Salim ULg; Nihoul, Jacques ULg

in Water Pollution Research (1991), 28

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See detailLa circulation utero-placentaire
Schaaps, Jean-Pierre ULg; Foidart, Jean-Michel ULg

in Revue Française de Gynécologie et d'Obstétrique (1991), 86(10), 579-84

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See detailOxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio ULg; Klingbiel, P. et al

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

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See detailMG1131 + 0456 - Discovery of the optical Einstein ring with the NTT
Hammer, F.; Angonin, M. C.; Le Fevre, O. et al

in Astronomy and Astrophysics (1991), 250

Deep optical imaging and spectroscopy have been obtained for the well known radio Einstein ring MG1131 + 0456 with the ESO/NTT. The direct CCD frames show a red emission excess at the exact location of ... [more ▼]

Deep optical imaging and spectroscopy have been obtained for the well known radio Einstein ring MG1131 + 0456 with the ESO/NTT. The direct CCD frames show a red emission excess at the exact location of the radio ring. Subsequent subtraction of the lensing galaxy, assumed to be an elliptical galaxy, results in the detection of an optical ring which is strikingly similar to the radio ring. Gravitational lensing models, including source reconstruction, predicts that the source is likely a radio-galaxy for which both the optical and extended radio emissions are sufficiently distorted by the foreground lensing galaxy as to produce a nearly complete ring. The present spectroscopy and broad band photometry suggest that the lensing galaxy has a spectral energy distribution typical of a nonevolved elliptical, tentatively at z of 0.85. The radio-galaxy associated with the radio-ring is likely to be an elliptical at larger redshift, tentatively of 1.13. [less ▲]

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See detailThe Lactate Dehydrogenase of the Icefish Heart: Biochemical Adaptations to Hypoxia Tolerance
Feller, Georges ULg; Pauly, J. P.; Smal, A. et al

in Biochimica et Biophysica Acta (1991), 1079(3), 343-7

Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or ... [more ▼]

Cardiac lactate dehydrogenase from the hemoglobin- and myoglobin-free antarctic icefish has been purified by affinity chromatography. Structural and kinetic properties of the enzyme were found close or identical to those of its skeletal muscle counterpart and other M-type lactate dehydrogenases. A model involving a dual oxidative-anaerobic metabolism of the icefish heart is proposed. [less ▲]

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See detailSelf-Labeling of Human Polymorphonuclear Leucocyte Myeloperoxidase with 125iodine
Deby, Ginette ULg; Pincemail, Joël ULg; Thirion, A. et al

in Experientia (1991), 47(9), 952-7

In order to obtain a radioimmunoassay (RIA) technique for the measurement of human plasma myeloperoxidase (MPO), we purified the enzyme from polymorphonuclear granulocytes (neutrophils), and compared ... [more ▼]

In order to obtain a radioimmunoassay (RIA) technique for the measurement of human plasma myeloperoxidase (MPO), we purified the enzyme from polymorphonuclear granulocytes (neutrophils), and compared three methods of labeling it with 125Iodine:chloramine T, lactoperoxidase, and an original technique of 'self labeling' based on the ability of the enzyme to oxidize and bind 125I in the presence of H2O2. The chloramine T technique produced a degraded protein, as well shown by a high non-specific binding of tracer to antibody. The lactoperoxidase technique did not succeed in labeling MPO with an adequate specific activity. In contrast, the self-labeling method gave a stable tracer with a specific activity of 23 microCi/micrograms MPO (85 MBq), a satisfactory level of immunoreactivity, and a low-specific binding (less than or equal to 3%). After labeling, purification of tracer was achieved by gel filtration chromatography in phosphate buffer (0.05 M; pH7) to which 0.1% poly-L-lysine was added. The labeled molecule remained stable for 40 days and could be used for RIA with a polyclonal antibody raised in rabbits. [less ▲]

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See detailThe Importance of the Negative Charge of Beta-Lactam Compounds in the Interactions with Active-Site Serine Dd-Peptidases and Beta-Lactamases
Varetto, Louis ULg; De Meester, Fabien; Monnaie, Didier et al

in Biochemical Journal (1991), 278((Pt 3)), 801-7

The interaction between various penicillins and cephalosporins the carboxylate group of which at C-3 or C-4 had been esterified or amidated and different penicillin-recognizing enzymes was studied. In ... [more ▼]

The interaction between various penicillins and cephalosporins the carboxylate group of which at C-3 or C-4 had been esterified or amidated and different penicillin-recognizing enzymes was studied. In general, our findings reinforced the common assumption that an anionic group at that position is necessary for the effective acylation of these enzymes. However, the relative activities of the modified beta-lactams as inactivators of the Streptomyces R61 DD-peptidase or as substrates of the Bacillus licheniformis, Streptomyces albus G and Enterobacter cloacae beta-lactamases did not fit a general scheme in which the intrinsic electronic and geometric properties of the beta-lactam compounds would be sufficient to explain their substrate or inactivator properties towards the various types of enzymes investigated. [less ▲]

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See detailAnionic polymerization of acrylic monomers. 6. Synthesis, characterization, and modification of poly(methyl methacrylate)-poly(tert-butyl acrylate) di- and triblock copolymers
Varshney, Sunil K; Jacobs, Christian; Hautekeer, Jean-Paul et al

in Macromolecules (1991), 24(18), 4997-5000

Poly(methyl methacrylate)-b-poly(tert-butyl acrylate) (PMMA-b-PtBA) copolymers have been successfully synthesized by the sequential anionic polymerization of methyl methacrylate (MMA) and tert-butyl ... [more ▼]

Poly(methyl methacrylate)-b-poly(tert-butyl acrylate) (PMMA-b-PtBA) copolymers have been successfully synthesized by the sequential anionic polymerization of methyl methacrylate (MMA) and tert-butyl acrylate (tBA) in THF at -78-degrees-C. Although the order of monomer addition makes a difference on the initiation efficiency, it has no significant effect on the final achievement. Mono- and bifunctional initiators based on alkali metals can be used. When the initiators are modified by LiCl as a ligand, the polymerization of each block appears to be living, the molecular weight and composition can be predicted, and the molecular weight distribution is narrow. Size exclusion chromatography supports the absence of homo-PtBA in the PtBA-b-PMMA samples. The PtBA blocks can be quantitatively hydrolyzed into polyacid ones as supported by titration and H-1 NMR analysis. [less ▲]

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See detailNon thermal nitrogen atoms in the earth's thermosphere. I - Kinetics of hot N(4S). II - A source of nitric oxide
Shematovich, V. I.; Bisikalo, D. V.; Gérard, Jean-Claude ULg

in Geophysical Research Letters (1991), 18

The energy distribution of translationally hot nitrogen atoms in the thermosphere has been calculated using a nonequilibrium kinetic model. Dissociation by solar EUV photons and photoelectrons is found to ... [more ▼]

The energy distribution of translationally hot nitrogen atoms in the thermosphere has been calculated using a nonequilibrium kinetic model. Dissociation by solar EUV photons and photoelectrons is found to provide an important source of non-Maxwellian high energy N(4S) atoms. It is shown that quenching of metastable N(2D) atoms by atomic oxygen also produces significant amounts of hot N(4S) atoms. The fraction of hot N atoms reacting with O2 is found to be about 15 percent of the production rate of atomic nitrogen by N2 dissociation by photon and photoelectron impact and quenching of N(2D) metastable atoms by atomic oxygen. The very fast reaction between hot N(4S) atoms and O2 is shown to provide an additional source of nitric oxide. At equatorial latitudes, this contribution amounts to 6-30 percent of the other classical production sources of NO for solar minimum activity conditions. It is concluded that the effect of hot N atoms must be considered in future models of the NO-N system chemistry. [less ▲]

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See detailNon thermal nitrogen atoms in the Earth's thermosphere. 2. A source of nitric oxide
Gérard, Jean-Claude ULg; Shematovich, V. I.; Bisikalo, D. V.

in Geophysical Research Letters (1991), 18

The role of the non maxwellian nitrogen atoms in the odd nitrogen thermospheric chemistry is investigated with a numerical model. This one-dimensional model solves the continuity equation, including ... [more ▼]

The role of the non maxwellian nitrogen atoms in the odd nitrogen thermospheric chemistry is investigated with a numerical model. This one-dimensional model solves the continuity equation, including molecular and turbulent transport for the coupled NO-N([SUP]4[/SUP]S) system. It is shown that the very fast reaction between hot N([SUP]4[/SUP]S) atoms and O[SUB]2[/SUB] provides an additional source of nitric oxide. At equatorial latitudes, this contribution amounts to 6-30% of the other classical production sources of NO for solar minimum activity conditions. The cross section for elastic collisions with ambient gas introduces the largest uncertainty on this estimate. It is concluded that, although it does not drastically alter the conclusions of previous models of NO, the effect of hot N atoms must be considered in future models of the NO-N system chemistry. [less ▲]

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See detailThe light curves of periodic Be stars in NGC 3766
Balona, L. A.; Sterken, C.; Manfroid, Jean ULg

in Monthly Notices of the Royal Astronomical Society (1991), 252

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of ... [more ▼]

Results of an intensive photometric campaign on four period Be stars in the southern open cluster NGC 3766 are presented as well as light curves covering the years 1985-1990. It is found that, in spite of dramatic changes in the shapes and amplitudes of the light curves, phase locking is maintained and the period is unchanged over the five-year interval. It is concluded that within observational limits there is no evidence for coherent multiperiodicity in any of the four stars. No obvious correlation is found between the amplitudes or shapes of the light curves and the H-alpha line profiles. These findings are discussed in the light of the nonradial pulsation and starspot hypotheses, and they are shown to be observationally indistinguishable. A model in which matter is trapped in a magnetic field and forced into corotation with the star is discussed. [less ▲]

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See detailGeneral catalogue of Ap and Am stars
Renson, Pierre ULg; Gerbaldi, M.; Catalano, F. A.

in Astronomy and Astrophysics. Supplement Series (1991), 89

A catalog of all the known Ap and Am stars, containing a total of 6684 objects, was prepared. The few stars that were wrongly considered as Ap or Am star are noted as well as some others for which their ... [more ▼]

A catalog of all the known Ap and Am stars, containing a total of 6684 objects, was prepared. The few stars that were wrongly considered as Ap or Am star are noted as well as some others for which their identity as Ap or Am stars is not yet well established. The catalog gives the identificators and the main observational data for each star, including the magnitude, color, spectral type, duplicity, periodicity, magnetic field, and projected rotational velocity. [less ▲]

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See detailEffect of treatment with octreotide on the morphology of growth hormone secreting pituitary adenomas : study of 24 cases.
Beckers, Albert ULg; Kovacs, K.; Horvwarth, E. et al

in Endocrine Pathology (1991), 2(3), 123-131

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological ... [more ▼]

Twenty-four acromegalic patients were treated with octreotide subcutaneously for periods of 3 to 6 weeks (group I, 12 cases) or 6 months (group II, 12 cases) before transsphenoidal surgery. Radiological studies performed in 19 patients before and at the end of this treatment period revealed no changes in 8 cases. In 8 other cases, a slight reduction in tumorsize was observed, and in 3 cases an important shrinkage was documented. At surgery, the adenomatous tissue appeared softer than in nonpretreated patients, facilitating the operation. Pathological examination revealed widening of perivascular spaces with accumulation of fibrous tissue and more crinophagy than in nonpretreated patients but failed to reveal morphologically pronounced cell involution as observed in prolactin-producing adenomas treated with dopamine agonists. No significant difference in frequency or extent of cellular changes was noted between the two groups. These morphological findings seem to be more consistent with a functional inhibition of growth hormone release than with cellular alterations induced by octreotide. [less ▲]

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See detailRectal cancer: need for radiotherapy in determining the treatment plan
Coucke, Philippe ULg; Bosset, J-F; Mirimanoff, R-O

in Helvetica Chirurgica Acta (1991), 58(3), 345-58

Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches ... [more ▼]

Postoperative radiotherapy is highly effective in the prevention of local recurrence in rectal cancer. Nevertheless, the results remain disappointing for Locally Advanced Rectal Cancer. New approaches include introduction of chemotherapy to postoperative radiotherapy or combined radiotherapeutic treatment with preoperative irradiation, surgery and intraoperative irradiation, along with elective postoperative treatment in function of surgical and pathological data. Based on recent advances in radiobiology we are able to modify treatment parameters to enhance efficacy without increasing the toxicity. The reduction of dose per fraction, the application of radiosensitizers, the optimal protection of healthy tissue will increase the therapeutic ratio while keeping results constant or even reduce the incidence of local failure. [less ▲]

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See detailTumeurs cutanées à papillomavirus. Intérêt de l'immunopathologie et de l'hybridation in situ
Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg; Fazaa, B. et al

in Revue Médicale de Liège (1991), 46(9), 480-485

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux ... [more ▼]

On connaît actuellement une soixantaine de papillomavirus humains. Ils sont responsables des verrues, des condylomes, de papillomes ainsi que de lésions maculeuses paucisymptomatiques. Certaines tumeux épithéliales, localement invasices ou franchement malignes sont également le reflet d'une infection par certains de ces papillomavirus. Nous présentons une brève revue des méthodes cliniques et histologiques qui peuvent être mises en oeuvre pour le dépistage et l'identification de ces atteintes virales. [less ▲]

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See detailAre Antibodies Responsible for a Decreased Superovulatory Response in Goats Which Have Been Treated Repeatedly with Porcine Follicle-Stimulating Hormone ?
Remy, Benoit; Baril, Gérard; Vallet, J. C. et al

in Theriogenology (1991), 36(3), 389-99

Repeated administration of xenogenic gonadotropins in human or animal species may be responsible for antibody production and refractoriness. An experiment was conducted in which goats were treated with ... [more ▼]

Repeated administration of xenogenic gonadotropins in human or animal species may be responsible for antibody production and refractoriness. An experiment was conducted in which goats were treated with porcine FSH (p-FSH) at 6-week intervals for a period of 7 months. A sensitive radioimmunoassay (RIA) was used to detect antibodies to p-FSH in plasma samples taken at short-term intervals during a 7-month period. Antibodies appeared after the first injection, and levels increased following booster injections. A high correlation rate existed between antibody level and superovulatory response. Refractoriness in goats was associated with a high level of antibodies. [less ▲]

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See detailLiège 1866-1991 : Mutations d’un espace urbain
Frankignoulle, Pierre ULg

in Gagnez (1991)

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See detailAcute Amphetamine-Induced Subsensitivity of A10 Dopamine Autoreceptors in Vitro
Seutin, Vincent ULg; Verbanck, Paul; Massotte, Laurent ULg et al

in Brain Research (1991), 558(1), 141-4

Extracellular recordings were obtained from spontaneously active, presumed dopamine (DA) neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied (+)-amphetamine (AMPH ... [more ▼]

Extracellular recordings were obtained from spontaneously active, presumed dopamine (DA) neurons of the ventral tegmental area (VTA) of the rat in a slice preparation. Bath-applied (+)-amphetamine (AMPH) (1-30 microM) induced a concentration-dependent decrease in the firing rate of these neurons, which tended to saturate with the highest concentrations used (n = 11). This inhibitory effect was dependent on the activation of D2 receptors since it was reversed by the D2 antagonist sulpiride (n = 8). However, the most striking effect of AMPH was the induction of a prominent subsensitivity of DA autoreceptors: whereas in 18 out of 20 control neurons, the D2 agonist BHT 920 (100 nM) produced a rapid and complete inhibition of the firing, this was observed in none out of 11 neurons 10 min after the end of the application of AMPH (1-30 microM) (P less than 0.001). In these cells, the mean percent inhibition produced by BHT 920 was only 47 +/- 8%. This subsensitivity remained unchanged after 20 min and declined after one hour. This effect was specific, since the sensitivity of GABAB receptors to baclofen (500 nM-1 microM) was not modified by the application of AMPH (n = 12). These results suggest that AMPH-induced DA autoreceptor subsensitivity can be produced acutely and may be the first step in a cascade of events leading to behavioral sensitization to this compound. [less ▲]

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See detailLes inhibiteurs de l'enzyme de conversion: la molécule a-t-elle de l'importance?
Rorive, Georges ULg; Krzesinski, Jean-Marie ULg

in Médecine et Hygiène (1991), 49

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension ... [more ▼]

De nombreuses, peut-être de trop nombreuses molécules, dotées d'un pouvoir d'inhibition de l'enzyme de conversion ont été introduites ces dix dernières années pour le traitement de l'hypertension artérielle et de l'asystolie. Les différences entre ces molécules sont peu importantes et sont fonction de leur structure moléculaire. Le captopril, seul dérivé doté d'un groupe sulfhydrile, a un effet rapide et de durée assez brève; son utilisation s'accompagne par ailleurs de certains effets secondaires propres au groupe SR. Par contre, le délai d'action des dérivés dont le ligand est un groupe carboxyle est généralement plus tardif, leur durée d'action plus longue, justifiant une prise par jour. Il reste difficile d'affirmer que le groupe SR confère des propriétés cardioprotectrices plus importantes que celles dont jouissent les autres molécules de cette classe thérapeutique. De la même manière, à ce stade, les différences démontrées concernant la diffusion tissulaire des inhibiteurs de l'enzyme de conversion n'ont pas pu être illustrées par des observations cliniques. [less ▲]

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See detailPaf-Receptor. iii. Conformational and Electronic Properties of Paf-Like Agonists and Antagonists
Lamotte-Brasseur, Josette; Dive, Georges ULg; Lamouri, Aazdine et al

in Biochimica et Biophysica Acta (1991), 1085(1), 91-105

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was ... [more ▼]

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was present in all agonists and all constrained or flexible antagonists. The distinction between agonists and antagonists appears to be casted on position-2 where the folded conformation of the substituent for agonists should be the most probable. In position-3 the gauche conformation can be adopted by all the analysed compounds. The electrostatic potential well at -30 kcal/mol stretches to the carbonyl group in position-2 in the folded conformation of the agonists. On the contrary, in constrained antagonists, a second negative zone appears around the carbamate group. Given the modelling results, the triethylammonium PAF analogue considered in literature as a weak agonist, was resynthesized and proved to be more potent than previously reported. These experimental results confirm our hypothesis in terms of a common conformation of agonist and antagonist PAF-like molecules. [less ▲]

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See detailInfrared Spectroscopic Measurements of the Vertical Column Abundance of Sulfur Hexafluoride, SF6, From the Ground
Zander, Rodolphe ULg; Rinsland, C.P.; Demoulin, Philippe ULg

in Journal of Geophysical Research (1991), 96(D8), 15447-15454

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International ... [more ▼]

The unresolved v3 band Q branch of sulfur hexafluoride, SF6, at 947.9 cm-1 has been identified and quantitatively analyzed in series of high-quality infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, and at the National Solar Observatory facility on Kitt Peak in Arizona. Series of monthly mean total vertical column abundances of SF6 above both stations, deduced from that feature with line-by-line nonlinear least squares fitting methods, are reported over the time intervals from June 1986 to June 1990 for the Jungfraujoch and from March 1981 to June 1990 for Kitt Peak. Assuming an exponential growth model for fitting these series of measurements, it is found that the vertical column abundances have increased at mean rates of 6.9 +- 2.8 %/yr above the Jungfraujoch (calculated columns of 2.99 x 10E13 molecules/cm2 in June 1986 and 3 94 x 10E13 molecules/cm2 in June 1990) and 6.6 +- 7.2 %/yr above Kitt Peak (calculated columns equal to 2.97 x 10E13 molecules/cm2 in June 1981 and 5.38 x 10E13 molecules/cm2 in June 1990), the uncertainties corresponding to 2 sigma confidence levels. These results are further discussed within the context of variability and compared with previously published measurements. [less ▲]

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See detailAdult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice
Tirelli, Ezio ULg; Jodogne, C.; Perikel, J. J.

in Brain Research. Developmental Brain Research (1991), 61(2), 207-215

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old ... [more ▼]

The neurobehavioral responsivity to peripherally injected muscimol, a gamma-aminobutyric acid-A (GABA-A) agonist, was assessed in infant (14-day-old), weanling (20-day-old) and young adult (53-day-old) outbred male mice. In the first experiment, relatively high doses of muscimol (ranging from 0.05 to 0.40 mg/kg in developing and from 0.50 to 3 mg/kg in adult animals) were found to dose-dependently induced solid catalepsy and ataxia, evaluated 5 times at 20-min intervals. In the second experiment, the GABA agonist was injected in dose ranges which include relatively small concentrations in order to assess its excitatory properties, observable in adults, on rearing and locomotion in developing mice. It appeared that levels of rearing and especially locomotion were enhanced at the low doses (0.025 and 0.050 mg/kg in developing, and 1.3 and 1.9 mg/kg in adult mice) and inhibited at the higher ones (0.150 mg/kg in developing and 1.9 and 2.5 mg/kg in adult mice). This adult-like biphasic action of muscimol in developing mice--excitation at low and depression/sedation at high doses--strongly suggests a full maturation of the GABA-A-related behavioral functions at a period of ontogeny where adult-like locomotion emerges. Given that previous studies have shown that muscimol can biphasically affect behavioral activity in newborn murines as well, it is suggested that GABA-related behavioral functions mature near-monotonically during ontogeny, unlike those related to other major neurotransmitter systems. [less ▲]

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See detailMode of Membrane Insertion and Sequence of a 32-Amino Acid Peptide Stretch of the Penicillin-Binding Protein 4 of Enterococcus Hirae
Jacques, Philippe; el Kharroubi, Aboubaker; Van Beeumen, Jozef et al

in FEMS Microbiology Letters (1991), 66(2), 119-123

Analysis of water-soluble derivatives of the Enterococcus hirae 75-kDa membrane-bound penicillin-binding protein 4 (PBP4) has yielded the amino acid sequence of a 32-amino acid polypeptide stretch. This ... [more ▼]

Analysis of water-soluble derivatives of the Enterococcus hirae 75-kDa membrane-bound penicillin-binding protein 4 (PBP4) has yielded the amino acid sequence of a 32-amino acid polypeptide stretch. This peptide is similar to peptide segments known to occur in the N-terminal domain of high-Mr PBPs of class B. The E. hirae PBP4 probably belongs to the same class. It is anchored in the membrane at the N-terminus of the polypeptide chain. [less ▲]

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See detailActive-Site Serine Mutants of the Streptomyces Albus G Beta-Lactamase
Jacob, Françoise; Joris, Bernard ULg; Frère, Jean-Marie ULg

in Biochemical Journal (1991), 277((Pt 3)), 647-52

By using site-directed mutagenesis, the active-site serine residue of the Streptomyces albus G beta-lactamase was substituted by alanine and cysteine. Both mutant enzymes were produced in Streptomyces ... [more ▼]

By using site-directed mutagenesis, the active-site serine residue of the Streptomyces albus G beta-lactamase was substituted by alanine and cysteine. Both mutant enzymes were produced in Streptomyces lividans and purified to homogeneity. The cysteine beta-lactamase exhibited a substrate-specificity profile distinct from that of the wild-type enzyme, and its kcat./Km values at pH 7 were never higher than 0.1% of that of the serine enzyme. Unlike the wild-type enzyme, the activity of the mutant increased at acidic pH values. Surprisingly, the alanine mutant exhibited a weak but specific activity for benzylpenicillin and ampicillin. In addition, a very small production of wild-type enzyme, probably due to mistranslation, was detected, but that activity could be selectively eliminated. Both mutant enzymes were nearly as thermostable as the wild-type. [less ▲]

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See detailHR Carinae - A luminous blue variable surrounded by an arc-shaped nebula
Hutsemekers, Damien ULg; van Drom, E.

in Astronomy and Astrophysics (1991), 248

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes ... [more ▼]

New high and medium dispersion spectroscopic observations of the luminous blue variable (LBV) star HR Car are presented, showing that this star has a multiple shell expanding atmosphere and undergoes spectral variations apparently correlated with the light variations similarly to the other LBVs. Most striking are the very broad emission wings (FWZI of about 3000 km/s) of the Balmer lines, reminiscent from the broad lines observed in the spectra of Of and WR stars. A kinematic distance of 5.4 kpc and a bolometric magnitude of -9.4 put HR Car among the most luminous stars of the Galaxy. The narrow band filter imagery also reveals an arc-shaped jet like nebula associated with HR Car. Spectroscopic observations of this nebula reveal an emission nature with very low excitation. Like the star itself, the nebula is characterized by a significant N/O overabundance, probably due to the presence of nuclear processed material ejected by the star. [less ▲]

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See detailStromgren six-colour photometry of SN 1987 A. I - Days 1 to 330
Helt, B. E.; Bibo, E. A.; Cuypers, J. et al

in Astronomy and Astrophysics. Supplement Series (1991), 89

Results are presented of photometric observations of SN1987A with the Danish 0.5-m telescope at La Silla for the period February 1987-January 1988, including color lines and magnitudes from day 1 to day ... [more ▼]

Results are presented of photometric observations of SN1987A with the Danish 0.5-m telescope at La Silla for the period February 1987-January 1988, including color lines and magnitudes from day 1 to day 300. For the first time, flux calibrations for H-beta passbands were derived. Included are also improved flux calibrations for the uvby passbands. [less ▲]

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See detailInduction of Thymocyte Proliferation by Supernatants from a Mouse Thymic Epithelial Cell Line
Villa-Verde, Dea; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Cellular Immunology (1991), 136(1), 113-21

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for ... [more ▼]

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for thymic hormone secretion, include morphologically and antigenically distinct subpopulations that may exert different roles in thymocyte maturation. The recent development of thymic epithelial cell lines provided an interesting model for studying thymic epithelial influences on T cell differentiation. Treating mouse thymocytes by supernatants from one of TEC line (IT-76M1), we observed an induction of thymocyte proliferation and an increase in the percentages of CD4-/CD8- thymocytes. This proliferation was largely inhibited when thymocytes were incubated with IT-76M1 supernatants together with an anti-thymulin monoclonal antibody, but could be enhanced by pretreating growing epithelial cells by triiodothyronine. We suggest that among the target cells for thymulin within the thymus, some putative precursors of early phenotype might be included. [less ▲]

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See detailA linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage
Rutz, HP; COUCKE, Philippe ULg; Mirimanoff, RO

in Radiotherapy & Oncology (1991), 21(4), 273-276

We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was ... [more ▼]

We assessed the dose-dependence of repair of potentially lethal damage in Chinese hamster ovary cells x-irradiated in vitro. The recovery ratio (RR) by which survival (SF) of the irradiated cells was enhanced increased exponentially with a linear and a quadratic component, namely xi and psi: RR = e xi D + psi D2. Survival of irradiated cells can thus be expressed by a combined linear-quadratic model considering four variable, namely alpha and beta for the capacity of the cells to accumulate sublethal damage, and xi and psi for their capacity to repair potentially lethal damage: SF = e(xi - alpha)D + (psi - beta)D2. [less ▲]

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See detailThe Fate of Mitochondrial Dnas of Mt+ and Mt- Origin in Gametes and Zygotes of Chlamydomonas
Beckers, M. C.; Munaut, Carine ULg; Minet, Arlette ULg et al

in Current Genetics (1991), 20(3), 239-43

In order to study the mechanism responsible for the uniparental transmission of the mitochondrial genome in crosses between Chlamydomonas reinhardtii and C. smithii, we have analyzed the fate of ... [more ▼]

In order to study the mechanism responsible for the uniparental transmission of the mitochondrial genome in crosses between Chlamydomonas reinhardtii and C. smithii, we have analyzed the fate of mitochondrial DNA during gametogenesis, zygospore differentiation and sporulation by hybridization experiments. Both mt+ and mt- gametes contain the same amount of mitochondrial DNA and the two parental genomes persist for several days in the zygotes. The DNA of mt+ origin is slowly eliminated during the period of zygote maturation. Light is required for total elimination of mt+ mitochondrial DNA in the zygospores. Using appropriate restriction enzymes, we have been unable to detect methylation of the mitochondrial DNA during gametogenesis or zygospore formation. The possibility that the mt+ mitochondria themselves are specifically eliminated in the course of zygote maturation is discussed. [less ▲]

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See detailModulation of Proteolytic Activity During Neuritogenesis in the Pc12 Nerve Cell: Differential Control of Plasminogen Activator and Plasminogen Activator Inhibitor Activities by Nerve Growth Factor and Dibutyryl-Cyclic Amp
Leprince, Pierre ULg; Rogister, Bernard ULg; Delree, P. et al

in Journal of Neurochemistry (1991), 57(2), 665-74

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 ... [more ▼]

Extracellular proteolysis is considered to be required during neuritic outgrowth to control the adhesiveness between the growing neurite membrane and extracellular matrix proteins. In this work, PC12 nerve cells were used to study the modulation of proteolytic activity during neuronal differentiation. PC12 cells were found to contain and release a 70-75-kDa tissue-type plasminogen activator (tPA) and a much less abundant 48-kDa urokinase-type plasminogen activator. A plasminogen activator inhibitor (PAI) activity with molecular sizes of 54 and 58 kDa was also detected in PC12 cell conditioned medium and formed high-molecular-mass complexes with released tPA. Release of PAI activity was dependent on treatment with nerve growth factor (NGF), whereas tPA synthesis and release were under control of a cyclic AMP-dependent mechanism and increased on treatment with dibutyryl-cyclic AMP [(But)2cAMP] or cholera toxin. Simultaneous treatment with NGF and (But)2cAMP resulted in increases of both tPA and PAI release and enhancement of tPA-PAI complex formation. The resulting plasminogen activator activity in conditioned medium was high in (But)2cAMP-treated cultures with short neuritic outgrowth but remained low in NGF- or NGF plus (But)2cAMP-treated cultures, where neurite extension was, respectively, large and very large. These results suggest that excess proteolytic activity may be detrimental to neuritic outgrowth and that not only PAI release but also tPA-PAI complex formation is associated with production of large and stable neuritic outgrowth. This can be understood as an involvement of PAI in the protection against neurite-destabilizing proteolytic activity. [less ▲]

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See detailKainate and Nmda Toxicity for Cultured Developing and Adult Rat Spiral Ganglion Neurons: Further Evidence for a Glutamatergic Excitatory Neurotransmission at the Inner Hair Cell Synapse
Lefèbvre, Philippe ULg; Weber, T.; Leprince, Pierre ULg et al

in Brain Research (1991), 555(1), 75-83

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory ... [more ▼]

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory neurons, we show that the afferent auditory neuronal population can be divided, on the basis of its sensitivity to the neuronotoxic effect of glutamate and its analogs, in at least 3 subpopulations, one responding to N-methyl-D-aspartate (NMDA), one responding to kainate and a third minor one unresponsive to NMDA, kainic acid and glutamate. No toxic effect of quisqualate is observed. The use of specific antagonists (kynurenate and 2-amino-5-phosphonovalerate (DAP-5) demonstrates the specificity of the receptors to the excitatory amino acids on the afferent auditory neurons. Afferent auditory neurons from adult rats can also be cultured and in these preparations only the large neurons are sensitive to glutamate, kainate and NMDA while the small neurons are not responsive, suggesting that a glutamatergic neurotransmission occurs only at this synapse between the inner hair cells and the large radial afferent auditory neurons. We also show that, in vitro, the organ of Corti releases, in response to an increased potassium concentration and in the presence of calcium, a toxic activity for the afferent auditory neurons that is antagonized by kynurenate and DAP-5. Pathophysiological implications are discussed. [less ▲]

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See detailDetermination of Absolute Strengths of N2 Quadrupole Lines From High-Resolution Ground-based IR Solar Observations
Demoulin, Philippe ULg; Farmer, C.B.; Rinsland, C.P. et al

in Journal of Geophysical Research (1991), 96(D7), 13003-13008

High-resolution, high signal-to-noise ratio, solar absorption spectra recorded with a Fourier transform spectrometer at the International Scientific Station of the Jungfraujoch, Switzerland, have been ... [more ▼]

High-resolution, high signal-to-noise ratio, solar absorption spectra recorded with a Fourier transform spectrometer at the International Scientific Station of the Jungfraujoch, Switzerland, have been analyzed to determine the strengths of several lines belonging to the S branch of the N2 (1-0) electric quadrupole vibration-rotation band centered at 2329.9168 cm-1. The method which was applied here was based on equivalent width measurements of lines observed over a broad range of air masses; extrapolation of these measurements to zero air mass gave the line strengths for the transitions S7 to S10, independent of half widths, an ambiguity unavoidable with the use of curve-fitting techniques. The resulting absolute accuracies of the line strengths derived here, estimated to be better than +-2.5% for S8, +-2.6% for S10, +-3.4% for S9, and +-5.1% for S7, are due largely to the high quality and quantity of the spectra retained in this analysis and the accuracy with which the observation conditions are known. An important application of the improved values for these N2 transitions, which have low initial ground state energies, is the direct determination of the line-of-sight atmospheric air masses associated with remotely sensed infrared spectroscopic observations. Positions of the N2 transitions studied here have further been redetermined with an absolute accuracy better than 0.0002 cm-1. [less ▲]

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See detailA database of Ap stars
Renson, Pierre ULg; Kobi, D.; North, P.

in Astronomy and Astrophysics. Supplement Series (1991), 89

A database for 3195 Ap stars, which can be used on an IBM-compatible personal computer, is described. It is essentially based on Renson's general catalogue of Ap and Am stars, but contains much additional ... [more ▼]

A database for 3195 Ap stars, which can be used on an IBM-compatible personal computer, is described. It is essentially based on Renson's general catalogue of Ap and Am stars, but contains much additional information. It operates within the Dbase III Plus system. [less ▲]

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See detailThe diurnal variation of NO, N(D-2), and ions in the thermosphere - A comparison of satellite measurements to a model
Rusch, D. W.; Gérard, Jean-Claude ULg; Fesen, C. G.

in Journal of Geophysical Research (1991), 96

A data base of parameters important to understanding the diurnal variation of odd-nitrogen and ions in the thermosphere near equinox, at low latitudes, and for quiet geomagnetic conditions is presented ... [more ▼]

A data base of parameters important to understanding the diurnal variation of odd-nitrogen and ions in the thermosphere near equinox, at low latitudes, and for quiet geomagnetic conditions is presented. The data base includes profiles of the odd-nitrogen species NO and N(D-2), the ions NO(+), O2(+), O(+), N2(+), and N(+); the total ion density; O and N2; and the neutral, ion, and electron temperatures. The measured time-dependent variations of NO, N(D-2), O2(+), and NO(+) compare favorably to the results of a time-dependent, photochemical, diffusion model for odd-nitrogen and ion chemistry. In particular, the model reproduces the rapid increase in NO density in the morning hours, the midafternoon maximum, and the late afternoon decrease. The model also reproduces the measured absolute densities for NO to within 20 percent over most of the diurnal cycle but falls below the measured density by as much as a factor of two in the late afternoon. [less ▲]

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See detailHD160529 - a New Galactic Luminous Blue Variable
Sterken, C.; Gosset, Eric ULg; Juttner, A. et al

in Astronomy and Astrophysics (1991), 247

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the ... [more ▼]

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the past eight years. In addition, pulsation-like variations with a quasi-period of 57 days and with a peak-to-peak amplitude of about 0.1 mag in b and y were found. The fading was not completely monotonous a fall of at least 0.2 mag in b and y within about 40 days around JD2446500 is particularly remarkable. This jump is accompanied by a change in the temperature-sensitive c[SUB]1[/SUB] index of about -0.14 mag. HD 160529 has become visually fainter and hotter during the past eight years, thus becoming a new case of a galactic Luminous Blue Variable (LBV). Model calculations on the basis of the photometry and previously published as well as new spectroscopic observations have shown HD 160529 to be a close counterpart of R 110, a recently discovered LBV in the LMC. From this comparison an absolute magnitude of M[SUB]V[/SUB] = -8.9 and a distance of 2.5 kpc is derived. The stellar parameters characterising the maximum state are estimated to be T[SUB]eff[/SUB] ≍ 8000 K, log g ≍ 0.55, R ≍ 330 R[SUB]sun[/SUB], from which the mass is estimated to be only M ≍ 13 M[SUB]sun[/SUB]. From the Hα profile a lower limit of the mass-loss rate of HD 160529 was calculated, which is about 10 times higher than that of R 110; this could be a consequence of the higher metallicity of the galactic LBV. The low mass of HD 160529 makes this luminous blue star a good candidate for a post-RSG (red supergiant phase) object, providing some evidence that (as sometimes argued) low metallicity is not a necessary prerequisite for evolution of massive stars backward to higher temperatures. [less ▲]

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See detailCalibration of the Alpha Centauri system - Metallicity and age
Noels-Grötsch, Arlette ULg; Grevesse, Nicolas ULg; Magain, Pierre ULg et al

in Astronomy and Astrophysics (1991), 247

The binary system Alpha Cen A and B, with its well known parallax, its high quality orbit and the reasonable hypothesis of a common origin and age for both components, is a useful test of stellar ... [more ▼]

The binary system Alpha Cen A and B, with its well known parallax, its high quality orbit and the reasonable hypothesis of a common origin and age for both components, is a useful test of stellar evolution models. Evolutionary sequences are computed for 1.085 and 0.9 solar masses with different values of Z, Y and alpha (= l/Hp). Adopting luminosities and effective temperatures as derived from the observations, Z = 0.04, Y = 0.32, alpha = 1.6 and t = 5 Gyr. The Z-value derived from evolutionary sequences is very sensitive to the difference in effective temperature between the two components. [less ▲]

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See detailAdulés, honnis,... réhabilités ? A propos des manuels scolaires
Jadoulle, Jean-Louis ULg

in Bulletin de Clio (1991), n°89

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See detailMultiple Clinical and Paraclinical Analyses of Chronic Tension-Type Headache Associated or Unassociated with Disorder of Pericranial Muscles
Schoenen, Jean ULg; Gérard, P.; De Pasqua, Victor ULg et al

in Cephalalgia : An International Journal of Headache (1991), 11(3), 135-9

Thirty-two female patients fulfilling the diagnostic criteria of chronic tension-type headache underwent multiple clinical (severity index before and after biofeedback therapy; anxiety score) and ... [more ▼]

Thirty-two female patients fulfilling the diagnostic criteria of chronic tension-type headache underwent multiple clinical (severity index before and after biofeedback therapy; anxiety score) and paraclinical (pericranial EMG levels and pressure-pain thresholds, temporalis exteroceptive silent period) assessments. Twenty-three patients (72%) had at least one increased EMG level and/or at least one decreased pain threshold and qualified for the subgroup" associated with disorder of pericranial muscles" (code 2.2.1). Nine patients (28%) were within the normal range for both investigations and would have been classified in the subgroup "unassociated with such disorder" (code 2.2.2). No significant differences were found between these two groups of patients for headache severity, anxiety, response to biofeedback therapy or duration of temporalis second exteroceptive silent period. The various clinical and paraclinical parameters were not significantly correlated to each other. It is therefore suggested that the subdivision of chronic tension-type headache in two subgroups based on pericranial EMG levels and/or pain sensitivity might be artificial. Since both of the latter and temporalis silent periods vary independently, they appear complementary in the study of tension-type headache patients and probably represent peripheral abnormalities, which are induced to varying intensities by a common central nervous system dysfunction. [less ▲]

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See detailImmunocytochemical study of cell type distribution in the pituitary of Barbus barbus (Teleostei, Cyprindidae)
Toubeau, Gérard; Poilve, A.; Baras, Etienne et al

in General and Comparative Endocrinology (1991), 83(1), 35-47

Antisera to mammalian pituitary and placental hormones have been used to identify and localize the different cell types in the pituitary of the barbel (Barbus barbus, L.). The immunocytochemical labeling ... [more ▼]

Antisera to mammalian pituitary and placental hormones have been used to identify and localize the different cell types in the pituitary of the barbel (Barbus barbus, L.). The immunocytochemical labeling employed the immunoperoxidase technique or the immunogold silver staining procedure. Corticotrophic and prolactin cells, visualized using antisera to human adrenocorticotropic hormone and ovine prolactin (PRL), respectively, occur in the rostral pars distalis (RPD). Antisera against mammalian gonadotropins [ovine folliclestimulating hormone (FSH); bovine luteinizing hormone] or porcine growth hormone selectively cross-react with two different cell populations occupying the major part of the proximal pars distalis (PPD). Thyrotropic cells, stained by an antiserum to whole human thyroidstimulating hormone preabsorbed with porcine FSH, are scattered throughout the PPD and found amongst growth hormone and gonadotrophic cells. The majority of pars intermedia cells are stained with anti-melanophore stimulating hormone whereas the scattered PAS positive cells are revealed by both anti-ovine PRL and anti-bovine placental lactogen (or chorionic somatomammotropin). The latter antiserum also cross-reacts with the PRL cells of the RPD. Our results indicate that the distribution of the different cell types in Barbus barbus is similar to that described in other families of teleosts. This report is also the first demonstration of antigenic similarity between mammalian placental lactogen and fish prolactin. [less ▲]

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See detailLung Fluid Dynamics and Supply Dependency of Oxygen Uptake During Experimental Endotoxic Shock and Volume Resuscitation
D'Orio, Vincenzo ULg; Mendes, P.; Carlier, Pierre ULg et al

in Critical Care Medicine (1991), 19(7), 955-62

BACKGROUND AND METHODS: We studied the effect of volume resuscitation on lung fluid balance and systemic oxygen extraction during septic shock in eight anesthetized dogs. Sepsis was induced using a 2-hr ... [more ▼]

BACKGROUND AND METHODS: We studied the effect of volume resuscitation on lung fluid balance and systemic oxygen extraction during septic shock in eight anesthetized dogs. Sepsis was induced using a 2-hr continuous infusion of Escherichia coli endotoxin at 0.25 micrograms/min.kg. Relationships between oxygen uptake (VO2) and oxygen supply (DO2) were performed acutely during stepwise controlled decrements in cardiac output by progressive inflation of an intracardiac balloon. At each stage, DO2 and corresponding VO2 were measured independently and the individual critical DO2 level was referred to as the point below which the relationship held. The slope of such a constructed relationship was defined as the maximal oxygen extraction ratio. Lung fluid balance was assessed by measurements of extravascular lung water. All values were studied at baseline, after endotoxin insult, and after reversing hypotension by a 10% dextran infusion. RESULTS: Endotoxin infusion led to a shock state that associated hypotension (from 135 to 63 mm Hg) with increases in blood lactate (from 0.53 to 3.9 mmol/L). The mean critical DO2 and maximal oxygen extraction ratio were significantly altered from 7.9 to 17.8 mL/min.kg and from 0.81 to 0.38, respectively. After reversing hypotension by 28 mL/kg colloid infusion, the critical DO2 (11.4 mL/min.kg) and maximal oxygen extraction ratio (0.48) were significantly improved. However, restoration of normal values required a state of fluid overload by further dextran infusion (8 mL/kg). At the end of the fluid challenge, extravascular lung water significantly increased from 6.4 to 17.4 mL/kg. CONCLUSIONS: These data suggest that volume loading may reverse endotoxin-induced peripheral perfusion abnormalities. However, substantial pulmonary edema may occur, possibly jeopardizing the beneficial effects of fluid expansion. [less ▲]

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See detailLa Galaxie McLuhan
Durand, Pascal ULg

in Liège-Université (1991)

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See detailMystification et démystification chez Alphonse Allais
Defays, Jean-Marc ULg

in French Studies (1991), XLV(3), 279-294

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See detailPurification and characterization of a bovine pregnancy-associated glycoprotein
Zoli, André Pagnah; Beckers, Jean-François ULg; Wouters-Ballman, Patricia et al

in Biology of Reproduction (1991), 45(1), 1-10

A 67000 Mr bovine pregnancy-associated glycoprotein (bPAG) has been isolated from fetal cotyledons and purified to homogeneity by HPLC. The purification was monitored by a double immunodiffusion test and ... [more ▼]

A 67000 Mr bovine pregnancy-associated glycoprotein (bPAG) has been isolated from fetal cotyledons and purified to homogeneity by HPLC. The purification was monitored by a double immunodiffusion test and by RIA in conjunction with an antiserum raised against a crude fraction of placenta-specific antigens. The molecular weight of bPAG was estimated to be 67000 by SDS-PAGE. The isoelectric points (pI) of the four isoforms, determined by high-resolution analytical electrofocusing in polyacrylamide gel, were 4.4, 4.6, 5.2, and 5.4. The carbohydrate content of the bPAG consisted of approximately 10.02 +/- 1.09% neutral sugar and variant amounts of sialic acid (from 0.29 +/- 0.06% in the most basic isoform to 2.1 +/- 0.31% in the most acidic isoform). A specific antiserum was raised against the purified bPAG. A specific RIA showed that the bPAG was antigenically unrelated to BSA, alphafetoprotein (AFP), and human schwangerschafts-spezifischen (pregnancy-specific) beta 1 glycoprotein (SP1). According to some characteristics (e.g. the molecular weight), the purified bPAG may correspond to a form of the pregnancy-specific protein B previously described by Sasser and colleagues (Biol Reprod 1986; 35:936-942). [less ▲]

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See detailRadioprotection de l'intestin grele dans le petit bassin par implantation de prothese siliconee gonflable
Cuttat, J-F; Delaloye, J-F; COUCKE, Philippe ULg et al

in Schweizerische Medizinische Wochenschrift (1991), 121(29), 1055-61

The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative ... [more ▼]

The combination of radiotherapy and surgery plays a major role in treating pelvic cancer. However, this technique is chiefly limited by the radiosensitivity of the small bowel following postoperative radiotherapy. In this situation the small bowel is not protected because of its lack of mobility. A radioprotective prosthesis is presented which is readily removable and whose purpose is to push the small bowel out of the pelvis during radiotherapy, thus protecting it from radiotherapy. If required, a simple system allows the prosthesis to be emptied and refilled between courses of radiotherapy, if required, without reoperation. This technique has been used in 4 patients: 2 had rectal carcinoma secondary to ulcerative colitis in one case and to Crohn's disease in the other; the other 2 cases were recurrent rectal carcinoma, one of which was partially resectable. When radiotherapy was completed the prosthesis could be deflated and removed through a short incision under local anesthetic. In the medium term, no small bowel complications were observed in spite of high-dose radiotherapy. When used for radiosensitive pelvic tumors, this technique combines low cost and ease of use with very low morbidity and the possibility of administering high-dose radiotherapy [less ▲]

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See detailFailure to Infect Cats with Bovine Herpesvirus Type-4 Strain Movar 33/63
Thiry, Etienne ULg; Chappuis, G.; Bublot, M. et al

in Veterinary Record : Journal of the British Veterinary Association (1991), 128(26), 614-5