References of "Article"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailCrystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.
Concha, N. O.; Janson, C. A.; Rowling, P. et al

in Biochemistry (2000), 39(15), 4288-98

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there ... [more ▼]

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there is a current lack of potent and selective inhibitors of metallo beta-lactamases. Reported here are the crystal structures of the native IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor, 2-[5-(1-tetrazolylmethyl)thien-3-yl]-N-[2-(mercaptomethyl)-4 -(phenylb utyrylglycine)]. The structures were determined by molecular replacement, and refined to 3.1 A (native) and 2.0 A (complex) resolution. Binding of the inhibitor in the active site induces a conformational change that results in closing of the flap and transforms the active site groove into a tunnel-shaped cavity enclosing 83% of the solvent accessible surface area of the inhibitor. The inhibitor binds in the active site through interactions with residues that are conserved among metallo beta-lactamases; the inhibitor's carboxylate group interacts with Lys161, and the main chain amide nitrogen of Asn167. In the "oxyanion hole", the amide carbonyl oxygen of the inhibitor interacts through a water molecule with the side chain of Asn167, the inhibitor's thiolate bridges the two Zn(II) ions in the active site displacing the bridging water, and the phenylbutyryl side chain binds in a hydrophobic pocket (S1) at the base of the flap. The flap is displaced 2.9 A compared to the unbound structure, allowing Trp28 to interact edge-to-face with the inhibitor's thiophene ring. The similarities between this inhibitor and the beta-lactam substrates suggest a mode of substrate binding and the role of the conserved residues in the active site. It appears that the metallo beta-lactamases bind their substrates by establishing a subset of binding interactions near the catalytic center with conserved characteristic chemical groups of the beta-lactam substrates. These interactions are complemented by additional nonspecific binding between the more variable groups in the substrates and the flexible flap. This unique mode of binding of the mercaptocarboxylate inhibitor in the enzyme active site provides a binding model for metallo beta-lactamase inhibition with utility for future drug design. [less ▲]

Detailed reference viewed: 50 (1 ULg)
Peer Reviewed
See detailEvidence for expression of some Microtubule-associated Protein 1B in neurons as a plasma membrane glycoprotein.
Franzen, Rachelle ULg; Tanner, Sandy; Jaffe, Howard et al

in Journal of Neurochemistry (2000), 75

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailClinical Usefulness of the Mini Nutritional Assessment (Mna) Scale in Geriatric Medicine
Gazzotti, C.; Albert, Adelin ULg; Pepinster, A. et al

in Journal of Nutrition, Health & Aging (The) (2000), 4(3), 176-81

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized ... [more ▼]

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized nutritional assessment upon admission by means of the MNA scale. Design: A prospective study. Setting: A large size regional university hospital. Subjects: There were 175 patients (113 women and 62 men) with a mean age of 79.7 + 8.5 years admitted for an acute problem. Death occurred in 11 patients (6.3%). METHODS: Upon admission, demographic (age, gender, origin) and medical (disease, drugs) data were recorded for each patient; the MNA questionnaire (score: 0-30) was administered and Katz score (7-28) calculated. At hospital discharge, data included Katz score, outcome (death/survival), and destination. RESULTS: The mean MNA score was 20.5 + 5.1 and the prevalence of severe malnutrition (MNA <17) was 21.7%. Further, 48.6% of elderly were at risk of malnutrition (MNA between 17 and 24). There was no association between MNA and age or gender, but underweight was a sign of low MNA values (P <.001). MNA scores were inversely related to Katz scores at both admission and hospital discharge (P <.001). Patients originating from nursing homes had a poorer nutritional status than those living at home (MNA: 18.4 against 22.3, P <.001). The number of drugs taken per patient (5.2 + 2.8) was found to be correlated with MNA (P =.049). MNA scores were on average significantly higher (P <.001) in survivors (20.9) than in nonsurvivors (14.1). CONCLUSIONS: The study clearly demonstrates the high prevalence of malnutrition and the clinical usefulness of the MNA scale in geriatric medicine. The MNA score upon admission reflects the patient's nutritional condition, degree of autonomy (Katz score), living conditions and current treatment. It is also predictive of patient's outcome (death or survival). [less ▲]

Detailed reference viewed: 42 (3 ULg)
Full Text
Peer Reviewed
See detailComparative Effects Of Deltamethrin And Neem Kernel Solution Treatments On Diamondback Moth And Cotesia Plutellae (Hym., Braconidae) Parasitoid Populations In The Cotonou Peri-Urban Area In Benin
Goudegnon, Ae.; Kirk, Aa.; Schiffers, Bruno ULg et al

in Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie (2000), 124(3-4), 141-144

Detailed reference viewed: 17 (0 ULg)
Full Text
Peer Reviewed
See detailEpidemiologie, physiopathologie et traitement d'une affection frequente: tinea pedis.
Lambert, Jean-Luc ULg; Richert, Bertrand ULg; Dezfoulian, Bita ULg et al

in Revue Médicale de Liège (2000), 55(3), 161-8

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly ... [more ▼]

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly responsible for the increase of cases of tinea pedis as dermatophytes grow preferentially in warm and humid environments. The clinical aspect is affected by several factors such as the host reaction to the infection, the virulence of the infective strain, species, and some local and environmental factors. If a dermatophytosis is suspected, it is mandatory to validate the provisional diagnosis by demonstration of the fungus (by culture or/and microscopic examination) to avoid useless and expensive treatments. The new antifungal molecules are very effective, well tolerated and allow short course of therapy improving the compliance of the patient in clinical practice. Relapse of tinea pedis is very common but could be avoided by several simple preventive measures of hygiene. [less ▲]

Detailed reference viewed: 146 (4 ULg)
Full Text
Peer Reviewed
See detailAerosol therapy in veterinary medicine : is it the future ?
Lekeux, Pierre ULg

in Veterinary Journal (2000), 160

Detailed reference viewed: 5 (0 ULg)
Full Text
See detailSynthesis of new hydrophilic γ-substituted poly(ε-caprolactone)s
Lecomte, Philippe ULg; D'aloia, Violetta; Mazza, Michaël et al

in Polymer Preprints (2000), 41(2), 1534-1535

Detailed reference viewed: 24 (1 ULg)
Full Text
Peer Reviewed
See detailZwitterionic (pyrrolidine-2,2-diyl)bisphosphonic acid at 100, 150 and 293K
Olive, Gilles ULg; Ellis, Dianne D; Siri, Didier et al

in Acta Crystallographica Section C-Crystal Structure Communications (2000), C56(6), 720-722

Structure of the zwitterionic pyrrolidine-2,2-diylbis(phosphonic acid) at 100, 150 and 293 K

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailEffects Of Multinutrient Blocks And Polyethylene Glycol 4000 Supplies On Intake And Digestion By Sheep Fed Acacia Cyanophylla Lindl. Foliage-Based Diets
Moujahed, Nizar; Kayouli, Chedly; Thewis, André ULg et al

in Animal Feed Science & Technology (2000), 88(3-4), 219-238

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based ... [more ▼]

The effect of multinutrient block supply and polyethylene glycol 4000 (PEG) on intake, digestion and rumen fermentation was studied in sheep fed with air-dried Acacia cyanophylla foliage (acacia)-based diet. In Experiment I, six Noire de Thibar breed sheep (BW 46 kg) were used in double 3 3 Latin square design. All diets included about 360 g of dry matter (DM) of oat±vetch hay and acacia ad libitum. Diet D0 was without a block supplement. Diet D1 included a urea± molasses±mineral block (B1). While D2 included another type of block (B2) that differed from B1 essentially by adding polyethylene glycol 4000. Each experimental period lasted 33 days (21 days for adaptation and two periods of 5 days for measurement separated by 2 days for rest). Feed intake, apparent digestibility of organic matter (OM), crude protein (CP) and crude ®bre (CF) and retained nitrogen (Nr) were measured by total faecal collection. In Experiment II, four Noire de Thibar sheep (BW 53 kg) ®tted with rumen cannulae were fed sequentially D0, D1 and D2, respectively, to 90% of intake levels as measured in Experiment I on metabolic weight (MW) base. Fermentation parameters in rumen liquid (pH, NH3-N, volatile fatty acid (VFA)) were measured at 0, 2, 5, 8, 10, 13, 16 and 21 h after the morning meal. Protozoal number and composition in rumen ¯uid were determined at 2 h sampling time. Solid digesta kinetics through the rumen was measured using chromium (Cr) mordanced acacia. The DM and CP degradation of acacia was determined using the nylon bag technique. Acacia had a relatively high content of condensed tannins (41 g kgÿ1 of DM) and acid detergent lignin (176 g kgÿ1 of DM). B1 and B2 were high in CP (381 and 369 g kgÿ1 of DM, respectively) compared to acacia (127 g kgÿ1 of DM, 20% bound to ®bre) and hay (75 g kgÿ1 of DM). The two kinds of blocks improved similarly (P < 0:001) acacia DM intake by 195 g. Block 1 increased (P < 0:001) only diet CP digestibility and Nr. Block 2 increased (P < 0:05) by a low extent DM and OM digestibility compared to D1, and remarkably (P < 0:001) CP digestibility and Nr compared to D0 and D1. Block supplies considerably increased water intake. Both B1 and B2 increased (P < 0:001) NH3-N and VFA concentrations in the rumen liquid with a positive speci®c effect of B2 (PEG). VFA molar proportion was signi®cantly modi®ed by B1 and B2. B1 and B2 decreased acetate proportion and increased propionate and butyrate proportions as compared to D0 (P < 0:001). Protozoal number in rumen ¯uid was increased signi®cantly by B1 and B2 (P < 0:001). PEG-containing block (B2) increased protozoal number as compared to B1. Both B1 and B2 increased (P < 0:001) solid out¯ow rate, with a speci®c increasing effect of B2 (D2) when compared to B1 (D1). Blocks supply did not modify in situ DM degradability of acacia, but B2 improved (P < 0:05) effective degradability of CP when compared to D0 and D1 which were similar. It is concluded that both B1 and B2 improved the nutritive value of acacia-based diet. A further positive effect was noted in D2 (PEG), especially for N metabolism. [less ▲]

Detailed reference viewed: 145 (3 ULg)
Peer Reviewed
See detailChanges in the moss layer after liming in a Norway spruce (Picea abies (L.) Karst.) stand of Eastern Belgium
Dulière, J.-F.; De Bruyn, R.; Malaisse, François ULg

in Forest Ecology & Management (2000), 136(1-3), 97-105

The impact of dolomite lime (5 t ha -1) on the moss layer was investigated in a Belgian Norway spruce (Picea abies (L.) Karst.) forest. Bryophytes reacted rapidly, showing a decrease in frequency, cover ... [more ▼]

The impact of dolomite lime (5 t ha -1) on the moss layer was investigated in a Belgian Norway spruce (Picea abies (L.) Karst.) forest. Bryophytes reacted rapidly, showing a decrease in frequency, cover and biomass of acidophilous dominant Dicranaceae species. Some neutrophilous competitive or stress tolerant species were spreading out and some ruderals appeared. The reaction of the dominant species coverage to different liming rates was also considered. Results showed that the negative effect was more pronounced than higher dolomite doses were. (C) 2000 Elsevier Science B.V. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailAffections musculaires et intolrance à l'effort. 1- Pathogénie et approche diagnostique
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical ... [more ▼]

The muscular condition, rhabdomyolysis, may cause exercise intolerance in the sporting horse. When the condition is recurring, it is often difficult for the equine practitioner to establish the clinical diagnosis (is the horse suffering from rhabdomyolysis or not ?) and the aetiology (what is/are the cause(s) of the condition ?) and also to provide an effective treatment [less ▲]

Detailed reference viewed: 110 (18 ULg)
Peer Reviewed
See detailHabituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack.
Judit, A.; Sandor, P. S.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2000), 20(8), 714-9

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked ... [more ▼]

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked cortical potentials (IDAP). Clinical observations of migraine prodromes and previously published electrophysiological studies suggest that cortical information processing may vary in close temporal relationship to the attack. We studied PR-VEP and IDAP just before (11 MO pts), during (23 MO, 3 MA), 1 day following (27 MO, 1 MA) and 2 days following (14 MO) a migraine attack. The results were compared with a large group of MO patients recorded at a distance of at least 3 days from an attack (n = 66 for IDAP; n = 39 for VEP). Patients recorded the day before the attack had on average an habituation of -13.6+/-20.5% (mean +/- SD) between the 5th and 1st block of 100 averaged VEP responses and a flat (0.38+/-1.06 microV/10 dB) amplitude-stimulus intensity function (ASF) slope of the auditory evoked cortical potential. Both values were significantly different from those obtained in the attack interval (P=0.003; P=0.020). During the attack, VEP habituation was less pronounced (-0.17+/-26.2%) and ASF slopes remained flat (0.32+/-1.44 microV/10 dB; P=0.002 compared to interval). During the 2 days following the attack, VEP habituation was replaced by potentiation (+0.09+/-29.1% the 1st day; 19.5+/-45.7% the 2nd day) and ASF slopes increased markedly (0.87+/-1.39 and 1.14+/-1.12 microV/10 dB). The normalization of evoked cortical responses just before and during the attack, might reflect an increase in the cortical preactivation level due to enhanced activity in raphe-cortical serotonergic pathways. [less ▲]

Detailed reference viewed: 31 (0 ULg)
Full Text
Peer Reviewed
See detailReactions involving inorganic compounds
Krief, A.; Delmotte, C.; Colaux, Catherine ULg

in Pure & Applied Chemistry (2000), 72(9), 1709-1713

Selenium chemistry became, over the last 30 years, particularly useful for synthetic organic chemistry [1]. Inorganic as well as organic selenium compounds allow transformation which otherwise cannot be ... [more ▼]

Selenium chemistry became, over the last 30 years, particularly useful for synthetic organic chemistry [1]. Inorganic as well as organic selenium compounds allow transformation which otherwise cannot be done or require much more drastic conditions to proceed. We have over the last 25 years explored the reactivity of elemental selenium as well as its inorganic and organic derivatives. We report here our recent finding concerning (i) organic diselenols and -diselenolates and (ii) the role of selenoxides in the enantioselective dihydroxylation of C,C double bonds using catalytic amounts of osmium tetroxide. [less ▲]

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detailCharacterization of intestinal cnf1+ Escherichia coli from weaned pigs
Toth, I.; Oswald, E.; Mainil, Jacques ULg et al

in International Journal of Medical Microbiology (2000), 290

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailEvidence-based medicine. Apport des etudes epidemiologiques.
REGINSTER, Jean-Yves ULg; BETZ, Romain ULg

in Revue Médicale de Liège (2000), 55(4), 211-5

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies ... [more ▼]

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies, based on their level of causality, cohort studies are ranked higher than case-control studies, mainly due to the fact that they allow direct collection of information on exposition to risk factors and health consequences. However, case-control studies can also provide an important information, if a specific effort is dedicated to the analyses of the circumstances of the exposition. Meta-analysis increases, by pooling them, the statistical power of individual studies of limited size. Meta-analysis can also be considered as an important source of evidence in the perspective of evidence-based medicine. [less ▲]

Detailed reference viewed: 55 (1 ULg)
Full Text
Peer Reviewed
See detailRe-entrant Peierls distortion in IV-VI compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Bichara, C. et al

in Physica B: Condensed Matter (2000), 276-278

At room temperature, the local structure of crystalline group V elements (As, Sb,middotmiddotmiddot) and their IV-VI isoelectronic compounds (GeSe,middotmiddotmiddot) is governed by a Peierls distortion ... [more ▼]

At room temperature, the local structure of crystalline group V elements (As, Sb,middotmiddotmiddot) and their IV-VI isoelectronic compounds (GeSe,middotmiddotmiddot) is governed by a Peierls distortion of the simple cubic or NaCl structure which is a symmetry breaking electronic instability. The morphology of the distortion is determined by the filling ratio of the p-band; for a half-filled p-band, the sixfold coordination becomes 3 (short, covalent) +3 (long, van der Waals). In general, at high temperature, the structure recovers its higher coordination number. Neutron diffraction experiments have been made in the liquid state at lambda=0.7 Aring. It is observed that the Peierls distortion is still present in the liquid for most IV-VI compounds. This behavior is observed and discussed for a series of Sn and Ge chalcogenides: SnS, SnSe, GeS, GeSe and GeTe and their temperature evolution is discussed. GeSe and GeTe show an interesting re-entrant phase behavior. The heaviest IV-VI compound SnTe does not show a distorted state. We demonstrate that the hardness of the repulsive potential is a key parameter in this mechanism [less ▲]

Detailed reference viewed: 38 (0 ULg)
Peer Reviewed
See detailChemical profiles of Amblystegium riparium, Fontinalis antipyretica and Rhynchostegium riparioides in the Grand-Duchy of Luxembourg
Vanderpoorten, Alain ULg; Ector, L.; Hoffmann, L.

in Nova Hedwigia (2000), 71(1-2), 209-221

Detailed reference viewed: 36 (0 ULg)
Full Text
See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2000)

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailLa garantie des droits fondamentaux et la convention européenne des droits de l'homme
Carlier, Jean-Yves ULg

in Revue Québecoise de Droit International (2000), 13(1), 37-62

Detailed reference viewed: 28 (1 ULg)
Peer Reviewed
See detailComparison between Open and Closed Repair for Abdominal Aortic Aneurysms: A Word of Caution
Limet, Raymond ULg; CREEMERS, Etienne ULg

in Acta Chirurgica Belgica (2000), 100(1), 12-5

Detailed reference viewed: 12 (0 ULg)
Full Text
Peer Reviewed
See detailComposition chimique du nététu, condiment alimentaire produit par fermentation des graines du caroubier africain Parkia biglobosa (Jacq.) Benth.
Ndir, Babacar; Lognay, Georges ULg; Wathelet, Bernard ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(2), 101-105

The seed oils and cakes of netetu of different origins available on the Senegalian market have been studied to evaluate the nutritional potentialities of this important food condiment used in many African ... [more ▼]

The seed oils and cakes of netetu of different origins available on the Senegalian market have been studied to evaluate the nutritional potentialities of this important food condiment used in many African countries. The total oil content ranged from 141 to 349 g.kg-1. Careful gas chromatography and GC-MS (Gas Chromatography-Mass Spectrometry) investigations revealed seven major fatty acids among which linoleic (41.9–46.8% of the total fatty acids), oleic (12.6–14.6%), palmitic (10.2–11.3%), stearic (10.0–13.4%), and behenic (12.6–13.4%) predominate. Significant differences were observed between fermented and non-fermented seeds as well as between netetu of different origins. The tocopherol content was found very low (17.7 to 30.6 mg.100g-1 fat). The total amino acid patterns showed that beside high level of proteins (331 à 540 g.kg-1) and interesting levels of essential constituents, there is an important deficiency of tryptophane, cysteine, methionine and threonine. [less ▲]

Detailed reference viewed: 326 (10 ULg)
Full Text
Peer Reviewed
See detailNeural mechanisms of antinociceptive effects of hypnosis.
Faymonville, Marie ULg; Laureys, Steven ULg; Degueldre, Christian ULg et al

in Anesthesiology (2000), 92(5), 1257-67

BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the ... [more ▼]

BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS: The protocol used a factorial design with two factors: state (hypnotic state, resting state, mental imagery) and stimulation (warm non-noxious vs. hot noxious stimuli applied to right thenar eminence). Two cerebral blood flow scans were obtained with the 15O-water technique during each condition. After each scan, the subject was asked to rate pain sensation and unpleasantness. Statistical parametric mapping was used to determine the main effects of noxious stimulation and hypnotic state as well as state-by-stimulation interactions (i.e., brain areas that would be more or less activated in hypnosis than in control conditions, under noxious stimulation). RESULTS: Hypnosis decreased both pain sensation and the unpleasantness of noxious stimuli. Noxious stimulation caused an increase in regional cerebral blood flow in the thalamic nuclei and anterior cingulate and insular cortices. The hypnotic state induced a significant activation of a right-sided extrastriate area and the anterior cingulate cortex. The interaction analysis showed that the activity in the anterior (mid-)cingulate cortex was related to pain perception and unpleasantness differently in the hypnotic state than in control situations. CONCLUSIONS: Both intensity and unpleasantness of the noxious stimuli are reduced during the hypnotic state. In addition, hypnotic modulation of pain is mediated by the anterior cingulate cortex. [less ▲]

Detailed reference viewed: 122 (11 ULg)
Full Text
Peer Reviewed
See detailKantvilasia (Lecanorales, Ectolechiaceae), a new foliicolous lichen genus from Tasmania
McCarthy, P.M.; Elix, J.A.; Sérusiaux, Emmanuël ULg

in Lichenologist (2000), 32

Detailed reference viewed: 8 (0 ULg)
Full Text
See detailL’internationalisation des entreprises de distribution. Quelques observations au départ du cas européen
Merenne-Schoumaker, Bernadette ULg

in Géographies. Bulletin de l'Association de Géographes Français (2000), (2000-1), 66-73

To understand the internationalization of retailing, we must understand the internationalization of its entreprises. With this aim in view, one first case is chosen - Europa - and the processus is learned ... [more ▼]

To understand the internationalization of retailing, we must understand the internationalization of its entreprises. With this aim in view, one first case is chosen - Europa - and the processus is learned through the main questions of geography : what where ? which evolution ? who ? how ? why and why there and not elsewhere ? The lead of territory in the strategies and the choices of the firms is clearly showed; this fact confirms the geographical relevance of the thema « Globalization of Retailing ». [less ▲]

Detailed reference viewed: 479 (2 ULg)
Peer Reviewed
See detailFate of the nucleolar vacuole during resumption of cell cycle in pea cotyledonary buds
Jennane, A.; Thiry, Marc ULg; Diouri, M. et al

in Protoplasma (2000), 210(3-4), 172-178

Meristematic cells of pea cotyledonary buds blocked in G(0-1) state contain a small nucleolus with a large central clear area surrounded by a fibrillar rim. The nucleolar structure varies according to the ... [more ▼]

Meristematic cells of pea cotyledonary buds blocked in G(0-1) state contain a small nucleolus with a large central clear area surrounded by a fibrillar rim. The nucleolar structure varies according to the cell cycle from the G(0-1)-blocked state until the first mitoses occurring between 24 and 27 h after removal of the main stem. In order to better identify and understand the role of the central area in the nucleolar function, its content was investigated by cytochemical and terminal deoxynucleotidyl transferase-immunogold methods. The central area showed the characteristics of a vacuole commonly constituted of the condensed chromatin, ribonucleoprotein granules, and lack of argyrophilic proteins. 3 h alter decapitation, a thickening of the fibrillar rim occurred, accompanied by an increase of granules in the vacuole. After 6 h, the unique vacuole broke up into two to four small vacuoles in which the granules are more abundant. After 12 h the nucleolus acquired compact structure with few minute vacuoles dispersed over the fibrillar component. During the whole cell cycle, the condensed chromatin is always observed in the vacuole. Our findings suggest that the appearance of the vacuoles is subsequent to the output of preribosomes from nucleolus. These vacuoles might play a role in condensation and decondensation of the chromatin. [less ▲]

Detailed reference viewed: 27 (1 ULg)
Full Text
Peer Reviewed
See detailLuxation traumatique du tendon du tibialis posterior.
Kakanou, A.; Liloku, R.; NCHIMI LONGANG, Alain ULg et al

in Acta Orthopaedica Belgica (2000), 66(5), 514-6

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical ... [more ▼]

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical treatment is easy and reportedly gives excellent results, but the diagnosis is difficult and absence of diagnosis may result in functional instability of the foot requiring more invasive surgical treatment. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Peer Reviewed
See detailUse of sequential estimation of regressions and effects on regressions to solve large multitrait test-day models
Gengler, Nicolas ULg; Tijani, A.; Wiggans, G. R.

in Journal of Dairy Science (2000), 83(2), 3691-36918

Detailed reference viewed: 8 (0 ULg)
See detailLa trisomie 21 : étude d’une stratégie de mémorisation
Frenkel, Stéphanie ULg

in Le Journal des Psychologues (2000), 182

Detailed reference viewed: 33 (8 ULg)
Full Text
Peer Reviewed
See detailMorphological comparison of the buccal apparatus in two bivalve commensal Teleostei : Encheliophis dubius and Onuxodon fowleri (Carapidae, Ophidiiformes)
Parmentier, Eric ULg; Castro-Aguirre, J. L.; Vandewalle, Pierre ULg

in Zoomorphology (2000), 120

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic ... [more ▼]

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic morphology to see whether 1) the head anatomy of both species is related to the constraints of their way of life, and 2) there are difference between these species and commensal carapids that shelter in other invertebrates. The components of their skeletons and muscles are similar, but differ in size and are arranged differently. In O. fowleri, the buccal cavity is smaller than in E. dubius, the jaws (bearing very large anterior teeth) are larger, the quadrato-mandibular joint lies further to the rear, the fibres of muscle bundles A3a, A2a and A2b are more vertical and insert higher on the neurocranium. The buccal system of O. fowleri appears better suited for ingesting food by biting and grasping. That of E. dubius seems better adapted to a feeding mechanism where sucking would have a more important role. The E. dubius head morphology is more similar to the cephalic anatomy of non-bivalve commensal species than to O. fowleri features. Diet constraints may have greater influence than the different host constraints on the head construction. A simulated backward rotation of the posterior part of the E. dubius suspensorium around the posterior joint between the hyomandibular and the neurocranium brings the jaws and the cheeks to coincide with those of O. fowleri. This model could be indicative of how structure modifications and their influences on annex pieces could in part have a role in the biodiversity. [less ▲]

Detailed reference viewed: 22 (1 ULg)
Peer Reviewed
See detailInfluence of ventilatory pattern on respiratory impedance measured by impulse oscillometry in horses
Van Erck, Emmanuelle ULg; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440(R219-R220),

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailLaparoscopic myolysis.
Donnez, Jacques; Sqifflet, Jean; Polet, Roland et al

in Human Reproduction Update (2000), 6(6), 609-13

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms ... [more ▼]

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms and global uterine volume in order to avoid hysterectomy. In the late 1980s, myolysis was performed laparoscopically with the help of the neodynium: yttrium aluminium garnet (Nd:YAG) laser. Later, bipolar needles were developed as an alternative to the Nd:YAG laser. Diathermy and cryomyolysis were also proposed but series are small in the literature. Very recently, myoma interstitial thermo-therapy (MITT) was performed using the diode laser and a specific optical light diffuser that is designed to transmit laser light in all directions. Laparoscopic myolysis was proved to be effective in provoking myoma shrinkage, with a dramatic decrease in size and a marked devascularization of the myoma and this technique can be proposed as an alternative to myomectomy in selected patients: only those aged >40 years or those not desiring to bear any more children. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailMujinga ou la soumission inconsciente à l’idéologie régnante
Vanhaegendoren, Koen ULg

in Congo-Meuse. Revue des lettres belges et congolaises de langue française (2000), 4-5

Detailed reference viewed: 57 (1 ULg)
Full Text
Peer Reviewed
See detailEigenschappen van glucosamine
Reginster, Jean-Yves ULg; Halkin, V

in Medi-Sfeer (2000), 116

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailLes populations de grands mammifères et d'autruches du Parc National de Zakouma au Tchad : statuts et tendances évolutives
Dejace, Philippe; Gauthier, Laure; Bouché, Philippe ULg

in Revue d'Ecologie (2000), 55

Zakouma National Park is situated in the south-east of Chad Republic and covers more than 3 000 km2. Rehabilitated in 1989, it is certainly one of the best-preserved wildlife sanctuaries in Sahelian ... [more ▼]

Zakouma National Park is situated in the south-east of Chad Republic and covers more than 3 000 km2. Rehabilitated in 1989, it is certainly one of the best-preserved wildlife sanctuaries in Sahelian Africa. Aerial census shows that most of its original fauna is still present, making the Park an exception in the region despite the recent troubled history of this country. Total population estimates of elephants, buffaloes and topis are given and distribution maps are presented for eleven species. Results are compared with two previous estimates. Except for the ostrich and perhaps the warthog, probably in regression, the populations of two species are stable (hartebeest and giraffe) while the others are clearly increasing (buffalo, topi, elephant and roan antelope). Those encouraging results are the consequence of the remoteness of the park, wich is far from any big town, and also overflooded and isolated during the wet season. Those facts contribute to maintain the human pressure at a sustainable level. [less ▲]

Detailed reference viewed: 74 (5 ULg)
Full Text
Peer Reviewed
See detailEffect of gonadal steroids on pituitary LH secretion and mediobasal hypothalamic GnRH mRNA in ferrets.
Bakker, Julie ULg; Baum, M. J.

in Journal of Reproduction and Fertility (2000), 119(2), 315-21

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the ... [more ▼]

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the present study was to determine whether this sex difference reflects a sexually dimorphic effect of gonadal steroids on mediobasal hypothalamic GnRH mRNA content of male and female ferrets killed 4 weeks after gonadectomy, either with or without steroid hormone replacement. This time interval exceeds the 6-10 days needed for increments in plasma LH concentrations to stabilize after gonadectomy of ferrets of both sexes. In situ hybridization using an (35)S-labelled oligoprobe complementary to the human GnRH coding region showed that the number of mediobasal hypothalamic neurones and the cellular content of GnRH mRNA did not differ significantly among groups of male and female ferrets that were either in breeding condition or that had been gonadectomized and treated with sex steroids or oil vehicle. These results indicate that gonadal hormones regulate mediobasal hypothalamic GnRH biosynthesis and release in both sexes via post-transcriptional events that may include GnRH mRNA translation or the conversion of pre-pro GnRH precursor into mature GnRH. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Peer Reviewed
See detailNekrotoxikus Escherichia coli (NTEC) törzsek magyarorszagi elöfordulasa és jellemzése
Nagy, B.; Toth, I.; Mainil, Jacques ULg et al

in Magyar Allatorvosok Lapja = Hungarian Veterinary Journal (2000), 122

Detailed reference viewed: 25 (2 ULg)
Full Text
Peer Reviewed
See detailCharacterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.
Liu, H.; Talmud, P. J.; Lins, Laurence ULg et al

in Biochemistry (2000), 39(31), 9201-12

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated ... [more ▼]

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated in lipid binding (L9T/T20L, F64A/W65A) or LPL inhibition (K21A), were compared. Relative lipid binding efficiencies to dimyristoylphosphatidylcholine (DMPC) were L9T/T20L > WT >K21A > F64A/W65A with an inverse correlation with size of the discoidal complexes formed. Physicochemical analysis (Trp fluorescence, circular dichroism, and GdnHCl denaturation) suggests that L9T/T20L forms tighter and more stable lipid complexes with phospholipids, while F64A/W65A associates less tightly. Lipid displacement properties were tested by gel-filtrating apoE:dipalmitoylphosphatidylcholine (DPPC) discoidal complexes mixed with the various apoC-III variants. All apoC-III proteins bound to the apoE:DPPC complexes; the amount of apoE displaced from the complex was dependent on the apoC-III lipid binding affinity. All apoC-III proteins inhibited LPL in the presence or absence of apoC-II, with F64A/W65A displaying the most inhibition, suggesting that apoC-III inhibition of LPL is independent of lipid binding and therefore of apoC-II displacement. Taken together. these data suggest that the hydrophobic residues F64 and W65 are crucial for the lipid binding properties of apoC-III and that redistribution of the N-terminal helix of apoC-III (L9T/T20L) enhances the stability of the lipid-bound protein, while LPL inhibition by apoC-III is likely to be due to protein:protein interactions. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailRecommandations pour le traitement de l'obesite.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(5), 367-71

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual ... [more ▼]

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual contempt for what is now considered as a chronic disease and especially the charlatanism which was observed among medical and non-medical spheres. Hence, as for numerous other pathologies, international guidelines have recently been published to optimize the management of obesity, from the view point of efficacy and, more particularly, safety. We will summarize the main recommendations as far as diet and physical treatment, pharmacotherapy and bariatric surgery are concerned. Finally, we will briefly describe general guidelines on the management of obese subjects taking into account the degree of weight excess and the presence of complications. [less ▲]

Detailed reference viewed: 160 (10 ULg)
Full Text
Peer Reviewed
See detailLa maladie de Kashin-Beck et le milieu rural au Tibet: un problème agri-environnemental
Haubruge, Eric ULg; Chasseur, Camille; Mathieu, Françoise et al

in Cahiers Agricultures (2000), 9

Detailed reference viewed: 32 (5 ULg)
Full Text
Peer Reviewed
See detailNotions de base de physiologie de l'effort
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic ... [more ▼]

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic metabolism also participates in the synthesis of ATP, which is essential for muscular contraction. The organism's oxygen consumption is proportional to the intensity of the effort, except during anaerobic metabolism. The maximum quantity of substrates that can oxygenate the muscles per unit time depends on the enzymatic material available. When the total aerobic capacity is used, the oxygen consumption is said to be maximal. The oxygen consumed at cellular level is taken from the ambient air at the areas of pulmonary exchange and transported throughout the body by the cardiovascular system. It is therefore essential that there is sufficient functional ability to adapt to cardiovascular and respiratory changes in order to ensure adequate O2 and nutrient transport and evacuation of CO2 and heat. The two systems adapt with exercise and training [less ▲]

Detailed reference viewed: 436 (22 ULg)
Full Text
Peer Reviewed
See detailSystematic study and stratigraphic correlation of the Grandispora complex in the Famennian of Northwest and Eastern Europe
Higgs, K.T.; Avkhimovitch, V.I.; Loboziak, S. et al

in Review of Palaeobotany and Palynology (2000), 112

Detailed reference viewed: 24 (2 ULg)
Full Text
Peer Reviewed
See detailThe effect of pressure on DSr (plag/melt) and DCr (opx/melt): implications for anorthosite petrogenesis
Vander Auwera, Jacqueline ULg; Longhi, John; Duchesne, Jean-Clair ULg

in Earth and Planetary Science Letters (2000), 178

Detailed reference viewed: 6 (1 ULg)
See detailLes artisans-producteurs face aux problèmes de conservation.
Sindic, Marianne ULg; Rolland, Sandrine

in Dieta (2000), (20), 6-7

Detailed reference viewed: 16 (1 ULg)
Peer Reviewed
See detailLa place de l'intervention de Ross (autogreffe pulmonaire) dans la chirurgie de la valve aortique
RADERMECKER, Marc ULg; GRENADE, Thierry ULg; Gach, J. et al

in Revue Médicale de Liège (2000), 55(1), 35-8

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in ... [more ▼]

The pulmonary autograft operation consists of an aortic replacement using the autologous pulmonary valve. The pulmonary valve is substituted by a cryopreserved pulmonary homograft. This operation is in fact a delicate double valve replacement whose benefits are linked to the viability of the new aortic substitute. The pulmonary autograft has superb hemodynamic features and very low thrombogenicity. The report of a selected observation offers the occasion of defining the current indications of this operation in aortic valve surgery. [less ▲]

Detailed reference viewed: 74 (0 ULg)
Full Text
See detailLe maillage vert... ou les réseaux de toute nature...
Mougenot, Catherine ULg; Melin, Eric ULg

in Cahiers de l'Urbanisme (Les) (2000), (28-29), 42-45

Depuis quelques années se développent un peu partout des projets de sentiers nature, de réseaux de cheminements lents, de création de mares, de jardin au naturel, etc. Ils peuvent être regroupés sous le ... [more ▼]

Depuis quelques années se développent un peu partout des projets de sentiers nature, de réseaux de cheminements lents, de création de mares, de jardin au naturel, etc. Ils peuvent être regroupés sous le terme de maillage vert ou de réseau écologique. L'article souligne que pour que de tels projets aboutissent, ils supposent une interaction étroite entre réseaux naturels et réseaux humains. [less ▲]

Detailed reference viewed: 112 (22 ULg)
Full Text
Peer Reviewed
See detailBackground for studies on the treatment of male osteoporosis: state of the art.
Kaufman, J M; Johnell, O; Abadie, Eric ULg et al

in Annals of the Rheumatic Diseases (2000), 59(10), 765-72

Male osteoporosis represents an important, although long underestimated, public health problem. Both in men and in women aging is accompanied by continuous bone loss and by an exponential increase in the ... [more ▼]

Male osteoporosis represents an important, although long underestimated, public health problem. Both in men and in women aging is accompanied by continuous bone loss and by an exponential increase in the incidence of osteoporotic fracture, with a female to male incidence ratio of about 2 to 3 to 1 in the elderly for hip and vertebral fractures. Morbidity after osteoporotic fractures appears to be more serious and mortality more common in men than in women. To date, no single treatment has been proved to be effective and safe in published prospective studies. The present report, based on a systematic search of the literature on male osteoporosis, summarises the state of the art on the clinical consequences of male osteoporosis and its risk factors, in relation to the present state of knowledge about female osteoporosis. This constitutes the background for the design of rational clinical development strategies for therapeutic interventions in male osteoporosis. From this review of the literature it is apparent that notwithstanding the existing sex differences in pathophysiology of osteoporosis and the difference in age-specific incidence of osteoporotic fractures, there are also important similarities between osteoporosis in women and men. The higher incidence of fracture in women than in men results from quantitative differences in risk factors rather than from different risk factors. Even though there are sex differences in bone geometry, incidence of fracture seems to be similar in men and women for a same absolute areal bone mineral density. However, the lack of data on the changes in fracture rates in men resulting from pharmacological intervention, leading to changes in bone mineral density or bone turnover, remains the main limitation for extrapolation of established treatment outcomes from women to men. [less ▲]

Detailed reference viewed: 37 (4 ULg)
Full Text
Peer Reviewed
See detailRole Of Surface Chemical Signals In Egg Cannibalism And Intraguild Predation In Ladybirds (Coleoptera : Coccinellidae)
Hemptinne, Jl.; Lognay, Georges ULg; Gauthier, Carole ULg et al

in Chemoecology (2000), 10(3), 123-128

The eggs of some ladybirds are known to be toxic to intraguild ladybird predators. However, this defence is of little value if the eggs are killed before their toxicity becomes apparent. The results ... [more ▼]

The eggs of some ladybirds are known to be toxic to intraguild ladybird predators. However, this defence is of little value if the eggs are killed before their toxicity becomes apparent. The results presented in this paper indicate that chemicals on the surface of the eggs of two species of ladybirds signal the relative risk of cannibalism and intraguild predation. In Adalia bipunctata and Coccinella septempunctata, 87% of the chemicals are alkanes. Each species of ladybird is less reluctant to eat their own eggs than those of the other species. This asymmetry is to be expected because there is a greater risk to ladybirds from intraguild predation than cannibalism. Similar alkanes to those on the surface of the eggs of A. bipunctata are present in tracks left by larvae and on the elytra of the adults of this species. Those in the larval tracks deter females from ovipositing in patches of prey already being attacked by their larvae and those on the elytra are used in mate recognition. That different context dependent messages could be signalled by similar chemicals is an example of semiochemical parsimony. [less ▲]

Detailed reference viewed: 13 (0 ULg)
See detailPour une démarche de qualité dans la formation continuée des enseignants : rôle de l'évaluation
Giot, Bernadette ULg

in Point sur la Recherche en Education (Le) (2000), 21

Detailed reference viewed: 20 (3 ULg)
Full Text
Peer Reviewed
See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

Detailed reference viewed: 9 (2 ULg)
Full Text
Peer Reviewed
See detailEffect of Temperature on Growth of Psychrophilic and Psychrotrophic Members of Rhodotorula Aurantiaca
Sabri, Ahmed ULg; Jacques, Philippe ULg; Weekers, Frederic et al

in Applied Biochemistry and Biotechnology (2000), 84-86(Spring), 391-9

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium ... [more ▼]

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium (Ardennes area). Cell production, maximum growth rate (mu max), and half-saturation constant for glucose uptake (Ks) of both yeasts were temperature dependent. For the two yeasts, a maximum cell production was observed at about 0 degree C, and cell production decreased when temperature increased. The mu max values for both strains increased with temperature up to a maximum of 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. For both yeasts, Ks for glucose was relatively constant at low temperatures. It increased at temperatures above 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. Although its glucose affinity was lower, the psychrotrophic strain grew more rapidly than the psychrophilic one. The difference in growth rate and substrate affinity was related to the origin of the strain and the adaptation strategy of R. aurantiaca to environmental conditions. [less ▲]

Detailed reference viewed: 176 (21 ULg)
Full Text
Peer Reviewed
See detailA survey on staging and treatment in uterine cervical carcinoma in the Radiotherapy Cooperative Group of the European Organization for Research and Treatment of Cancer
Coucke, Philippe ULg; Maingon, P; Ciernik, I et al

in Radiotherapy & Oncology (2000), 54

Abstract Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the ... [more ▼]

Abstract Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the European Organization for Research and Treatment of Cancer (EORTC), we conducted a survey in 1997±1998 to determine the variability of pre-treatment assessment and treatment options. The variability of choosing surgery, de®ned radiation therapy techniques and chemotherapy are investigated, as well as the center's choices of future treatment strategies. Methods: Fifty two of 81 RCG centers from the RCG have participated in the survey. As one would expect, there is a large variation in the techniques used for pretreatment evaluation and treatment options. There is no `standard' for reporting acute and late side effects. Chemotherapy is used neither systematically nor uniformly, and some centers continue to use neadjuvant chemotherapy modalities. Results: Furthermore, the survey reveals that there is a strong demand for the reduction of overall treatment-time, for clinical investigation of novel combined modality treatment strategies, especially chemo±radiation therapy, and also for the use of new radiation sensitizers. Conclusion:We conclude that a more homogeneous approach to the pretreatment evaluation as well as treatment techniques is required in order to allow adequate quality control in any future trial of the RCG in the EORTC.q2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 16 (1 ULg)
See detailLes brulis, un outil de gestion de la faune en region Afrique inter-tropicale.
Cornelis, D.; Lungren, C.; Ouedraogo, Mohamar moussa ULg et al

in Parcs & Réserves (2000), 55(3-4),

Detailed reference viewed: 34 (13 ULg)
Peer Reviewed
See detailMultimedia education in headache: the European Neurological Network.
Russell, M. B.; Dremstrup Nielsen, K.; Rasmussen, C. et al

in European Journal of Neurology (2000), 7(3), 355-62

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve ... [more ▼]

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve their management of sleep disorders, epilepsy and headache. The project involves approximately one hundred engineers and physicians from Belgium, Denmark, England, Finland, France, Germany, Italy, Portugal and Spain. This paper concerns the multimedia educational tool on headache. The system consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. The headache classification of the International Headache Society is provided in full text as a work of reference. This classification is used world wide and has been adopted by International Classification of Diseases 10 Neurological Adaptation (ICD-10 NA) and the World Health Organisation. The clinical data concentrate on migraine and tension-type headache, the two most common headache disorders, but data on familial hemiplegic migraine, cluster headache, drug-induced headache and secondary headaches are also available. The headache tutorial consists of case records that the user can test their diagnostic abilities on. The diagnostic headache diary is an expert system on headache diagnostics. It can be filled in during a consultation in order to provide the headache diagnosis or it can be printed and used by the headache patient to record headache attacks and medicine consumption. The nomenclature module provides an explanation of words and expressions used in the system. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
See detailLes rhyncholites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (2000), 33

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailAuditory steady-state response and bispectral index for assessing level of consciousness during propofol sedation and hypnosis.
Bonhomme, Vincent ULg; Plourde, Gilles; Meuret, Pascal et al

in Anesthesia and analgesia (2000), 91(6), 1398-403

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects ... [more ▼]

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects to obtain effect-site concentrations of 1, 2, 3, and 4 microg/mL. The ASSR and BIS index were recorded during baseline and at each concentration. The ASSR was evoked by monaural stimuli. Propofol caused a concentration-dependent decrease of the ASSR and BIS index values (r(2) = 0.76 and 0.93, respectively; P<0.0001). The prediction probability for loss of consciousness was 0.89, 0.96, and 0.94 for ASSR, BIS, and arterial blood concentration of propofol, respectively. In Experiment 2, we compared the effects of binaural versus monaural stimulus delivery on the ASSR in six subjects during awake baseline and propofol-induced unconsciousness. During baseline, the ASSR amplitude with binaural stimulation (0.47+/-0.13 microV, mean +/- SD) was significantly (P<0.002) larger than with monaural stimulation (0.35+/-0.11 microV). During unconsciousness, the amplitude was 0.09+/-0.09 microV with monaural and 0.06+/-0.04 microV with binaural stimulation (NS). The prediction probability for loss of consciousness was 0.97 (0.04 SE) for monaural and 1.00 (0.00 SE) for binaural delivery. We conclude that the ASSR and BIS index are attenuated in a concentration-dependent manner by propofol and provide a useful measure of its sedative and hypnotic effect. BIS was easier to use and slightly more sensitive. The ASSR should be recorded with binaural stimulation. The ASSR and BIS index are both useful for assessing the level of consciousness during sedation and hypnosis with propofol. However, the BIS index was simpler to use and provided a more sensitive measure of sedation. IMPLICATIONS: We have compared two methods for predicting whether the amount of propofol given to a human subject is sufficient to cause unconsciousness, defined as failure to respond to a simple verbal command. The two methods studied are the auditory steady-state response, which measures the electrical response of the brain to sound, and the bispectral index, which is a number derived from the electroencephalogram. The results showed that both methods are very good predictors of the level of consciousness; however, bispectral was easier to use. [less ▲]

Detailed reference viewed: 31 (0 ULg)
Full Text
Peer Reviewed
See detailUnawareness of illness in chronic schizophrenia and its relationship to structural brain measures and neuropsychological tests
Laroi, Frank ULg; Fannemel, M.; Ronneberg, U. et al

in Psychiatry Research : Neuroimaging Section (2000), 100(1), 49-58

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailThe Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases.
Boschi, L.; Mercuri, Paola ULg; Riccio, M. L. et al

in Antimicrobial agents and chemotherapy (2000), 44(6), 1538-43

A metallo-beta-lactamase determinant was cloned from a genomic library of Legionella (Fluoribacter) gormanii ATCC 33297(T) constructed in the plasmid vector pACYC184 and transformed into Escherichia coli ... [more ▼]

A metallo-beta-lactamase determinant was cloned from a genomic library of Legionella (Fluoribacter) gormanii ATCC 33297(T) constructed in the plasmid vector pACYC184 and transformed into Escherichia coli DH5alpha, by screening for clones showing a reduced susceptibility to imipenem. The product of the cloned determinant, named FEZ-1, contains a 30-kDa polypeptide and exhibits an isoelectric pH of 7.6. Sequencing revealed that FEZ-1 is a molecular-class B beta-lactamase which shares the closest structural similarity (29.7% of identical residues) with the L1 enzyme of Stenotrophomonas maltophilia, being a new member of the highly divergent subclass B3 lineage. All the residues that in L1 are known to be directly or indirectly involved in coordination of the zinc ions were found to be conserved also in FEZ-1, suggesting that the geometry of zinc coordination in the active site of the latter enzyme is identical to that of L1. Unlike L1, however, FEZ-1 appeared to be monomeric in gel permeation chromatography experiments and exhibited a distinctive substrate specificity with a marked preference for cephalosporins and meropenem. The properties of FEZ-1 overall resembled those of a beta-lactamase previously purified from the same strain of L. gormanii (T. Fujii, K. Sato, K. Miyata, M. Inoue, and S. Mitsuhashi, Antimicrob. Agents Chemother. 29:925-926, 1986) and are as yet unique among class B enzymes, reinforcing the notion that considerable functional heterogeneity can be encountered among members of this class. A system for overexpression of the bla(FEZ-1) gene in E. coli, based on the T7 phage promoter, was also developed. [less ▲]

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailMolecular diversity of Microcystis strains (Cyanophyceae, Chroococcales) based on 16S rDNA sequences
LEPERE, Claire ULg; Wilmotte, Annick ULg; Meyer, Barbara

in Systematics and Geography of Plants (2000), 70

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These ... [more ▼]

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These sequences appear very similar to each other and to those of 71 Microcystis strains from four continents available in the databases. This great genotypic homogeneity, as measured by 16S rDNA sequence similarity (334 characters), is contrasting with the conspicuous morphological differences observed for the studied strains. [less ▲]

Detailed reference viewed: 102 (5 ULg)
Full Text
Peer Reviewed
See detailLes sartans face aux inhibiteurs de l'enzyme de conversion de l'angiotensine en présence d'une hypertension artérielle
Krzesinski, Jean-Marie ULg; Sternon, J.

in Revue Médicale de Bruxelles (2000), 21(3), 170-177

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailHigh production of SPARC/osteonectin/BM-40 in mouse metastatic B16 melanoma cell lines
Kato, Y.; Frankenne, F.; Noël, Agnès ULg et al

in Pathology Oncology Research (2000), 6(1), 24-26

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in ... [more ▼]

Abstract Production of SPARC/osteonectin/BM-40 was determined in mouse B16 melanoma clones BL6 and F10 (high metastatic) and F1 (low metastatic). SPARC was produced greater amount in BL6 and F10 than in F1 cells, showing a good agreement with their metastatic potentials. Moreover, SPARC production was not influenced by culture pH, even in the acidic conditions (= pH 5.9). Although tumor tissues show often low pH due to excessive amount of acidic metabolites such as lactate, most studies have been done in neutral pH. High SPARC production in the acidic medium, therefore, is thought to be an important potential for tumor invasive behaviour. [less ▲]

Detailed reference viewed: 1 (0 ULg)
Full Text
Peer Reviewed
See detailDe la relation spatiale entre les personnages des groupes statuaires royaux en Égypte pharaonique
Laboury, Dimitri ULg

in Revue d'Egyptologie (2000), 51

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional ... [more ▼]

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional art such as statuary, considering the case of the royal statue groups [less ▲]

Detailed reference viewed: 42 (2 ULg)
Full Text
Peer Reviewed
See detailHet botkapitaal : een spaarboekje dat in de wieg begint
Halkin, V; Reginster, Jean-Yves ULg

in De Agenda Pediatrie (2000), 22

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailExpression of receptors for insulin-like growth factor-I and transforming growth factor-beta in human follicles.
Qu, Jian Ping; GODIN, Pierre-Arnaud ULg; NISOLLE, Michelle ULg et al

in Molecular Human Reproduction (2000), 6(2), 137-45

The in-vitro growth of immature oocytes in early follicles from cryopreserved human ovarian tissues is a new concept in in-vitro fertilization programmes for the treatment of infertile and cancer patients ... [more ▼]

The in-vitro growth of immature oocytes in early follicles from cryopreserved human ovarian tissues is a new concept in in-vitro fertilization programmes for the treatment of infertile and cancer patients. To better understand the regulatory mechanism of follicular development, immunohistochemistry was used to study the expression of insulin-like growth factor (IGF) type I receptor (IGF-IR) and transforming growth factor-β (TGFβ) type I (TβR-I) and type II (TβR-II) receptors in fresh and frozen ovarian tissues from 14 women. Immunoreactivities for IGF-IR and TβR-I were present simultaneously in the oocytes of primordial, pre-antral and antral follicles. Staining for both IGF-IR and TβR-I was also observed in granulosa cells of primordial, pre-antral and antral follicles. IGF-IR and TβR-I also stained in thecal cells of pre-antral and antral follicles. Stromal cells in surrounding ovarian tissue expressed IGF-IR and TβR-I at various follicular stages. Unlike TβR-I, TβR-II was expressed only in the oocytes of primordial and primary follicles, and with weak staining intensity in thecal cells. No significant staining for TβR-II was found in oocytes and granulosa cells of antral follicles. There was no difference in staining patterns for IGF-IR, TβR-I and TβR-II between fresh and frozen ovarian tissues, indicating that cryopreservation might not significantly alter the immunoreactivities of these receptors in frozen ovarian tissue. The results suggest that IGF-I and TGFβ may participate in the regulation of follicular growth by binding to their receptors through an autocrine or paracrine mechanism. IGF-I and TGFβ may be useful in regulating the in-vitro or in-vivo maturation of oocytes not only in later follicles but also very early follicles, from cryopreserved ovarian tissues for clinical use in the future. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailChemical changes and influences of rapeseed antinutritional factors on lamb physiology and performance. 3. Antinutritional factors in plasma and organs
Mabon, N.; Mandiki, S. N. M.; Derycke, G. et al

in Animal Feed Science & Technology (2000), 85(1-2), 111-120

The impact of a high level of rapeseed meal in the diet on the concentration of antinutritional factors in plasma and organs was studied in 66 Texel, Suffolk or crossbred lambs. From 1 month of age till ... [more ▼]

The impact of a high level of rapeseed meal in the diet on the concentration of antinutritional factors in plasma and organs was studied in 66 Texel, Suffolk or crossbred lambs. From 1 month of age till slaughter (132+/-21 days), they were fed ad libitum with concentrates containing 0% or 25% of rapeseed meal obtained either Samourai or Honk rapeseed varieties. Lambs were weaned at 88+/-8 days of age and 24+/-5 kg live weight. Blood and organ samples were taken fortnightly for the determination of antinutritional factors. In plasma and organs, the thiocyanate concentrations were systematically higher in the Samourai and Honk lots than in the control. After weaning, the SCN- concentration in plasma increased up to 490 mu mol l(-1) in the Samourai lot. The goitrogen 5-vinyl-1,3-oxazolidine-2-thione (5-VOT) was determined in muscle, organs (thyroid, liver, kidney and lung) and biological fluid (plasma). The 5-VOT was present only after the ingestion of rapeseed meal but not to the same extent for the two varieties. The Honk rapeseed meal induced a 5-VOT level significantly (p<0.05) higher in the target organs such as lung and thyroid than Samourai. Very low levels were found in muscle, liver, kidney, plasma and lung. (C) 2000 Elsevier Science B.V. All rights reserved. [less ▲]

Detailed reference viewed: 57 (1 ULg)
Full Text
Peer Reviewed
See detailLa chondroprotection aujourd’hui
Reginster, Jean-Yves ULg; Ethgen, Olivier ULg; Dang Vu, T

in Rhumatologie (2000), 52(8), 13-16

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailDependency of Premature Ventricular Contractions on Heart Rate and Circadian Rhythms During Childhood
Massin, M. M.; Maeyns, K.; Withofs, Nadia ULg et al

in Cardiology (2000), 93(1-2), 70-3

The aim of the present study was to identify and quantify the rate dependence of premature ventricular contractions (PVC) during childhood. A 24-hour Holter recording was performed in 16 consecutive ... [more ▼]

The aim of the present study was to identify and quantify the rate dependence of premature ventricular contractions (PVC) during childhood. A 24-hour Holter recording was performed in 16 consecutive children, aged 22 days to 11 years (mean age 5.6 years), with frequent (>5,000/day), isolated monomorphic PVC. Those PVC were identified and the length of the preceding sinus cycle was measured. The values were ordered into 50-ms class intervals, and the percentage of PVC for each class was calculated and then analyzed by linear regression analysis. On the basis of the significance of the p value, and the positive or negative value of the slope, we identified a tachycardia-enhanced, a bradycardia-enhanced, and an indifferent pattern. Chronobiologic analysis was made by the cosinor method. All the patients had upper and lower limits of cycle length beyond which PVC disappeared. A tachycardia-enhanced pattern was present in 7 patients and an indifferent one in 9 patients. In the latter a second-degree polynomial correlation was systematically found. Children but not infants had a significant circadian variation in the frequency of PVC with a very variable time of highest incidence. In conclusion, it is possible to identify a circadian rhythm of PVC and a spontaneous trend between their incidence and the length of the preceding cardiac cycle in children. [less ▲]

Detailed reference viewed: 30 (1 ULg)
Full Text
Peer Reviewed
See detailTectonic vs. shallow origin of geodetically inferred ground movements: an NE Ardenne (Belgium) case
Demoulin, Alain ULg; Vliegen, Bernard; Charlier, Robert ULg

in Earth and Planetary Science Letters (2000), 181(1-2), 217-228

In order to get a better insight into the temporal pattern of height change variations in a moderately seismic intraplate area, a 1 km long section has been weekly leveled from April, 21, 1997 to January ... [more ▼]

In order to get a better insight into the temporal pattern of height change variations in a moderately seismic intraplate area, a 1 km long section has been weekly leveled from April, 21, 1997 to January, 12, 1998 in NE Ardenne (Belgium). As this section is located very close to a small reservoir of 25 X 10(6) m(3), it also allowed the influence of lake level variations on the nearby ground motion to be studied. The measured height difference variations show a maximum amplitude of 3.45 mm, with weekly values not exceeding 1 mm. A two-dimensional (2D) finite element modeling confirms that waterload variations in the lake are the primary cause of movement of the section, inducing maximum ground subsidence of about 2 cm and seasonal tilting of 3-4 mu rads within a range of 2-3 km. We also show that a fault passively alters the spatial distribution of the waterload-dependent movements. The removal of this component from the observed ground motion leaves oscillating residual displacements characterized by an amplitude of 1-1.5 mm and a 'period' of about 2 months. We demonstrate that these displacements are independent of rainfall and probably of groundwater fluctuation too. Although most of the residual motions take place on the fault straddled by the leveling section, no credible mechanism can be found to ascribe these motions to a tectonic process. (C) 2000 Elsevier Science B,V. All rights reserved. [less ▲]

Detailed reference viewed: 52 (16 ULg)
Full Text
Peer Reviewed
See detailLa prise en charge de patients Alzheimer au stade débutant : Rôle d'un centre de jour
Adam, Stéphane ULg; Van der Linden, Martial ULg

in Rééducation Orthophonique (2000), 201

Detailed reference viewed: 192 (13 ULg)
Full Text
Peer Reviewed
See detail"note sous J.P. Jumet, 24 février 2000"
Moreau, Pierre ULg

in Actualités du Droit (2000)

Detailed reference viewed: 131 (0 ULg)
Full Text
Peer Reviewed
See detailInfluence du 'sense of coherence' dans l'adaptation aux conséquences aversives du traumatisme
François, G.; Brouette, Béatrice ULg; Etienne, Anne-Marie ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2000), V(1), 20-27

Detailed reference viewed: 30 (0 ULg)
Full Text
Peer Reviewed
See detailThe effect of electron-phonon interaction in iron-doped III-V cubic semiconductors
Colignon, David ULg; Kartheuser, Eduard ULg; Villeret, Murielle

in Journal of Physics : Condensed Matter (2000), 12(12), 2691-2699

A theoretical study of optical absorption and emission measurements of Fe2+ as a substitutional impurity in InP and GaP is presented. A new interpretation of the low-temperature absorption spectrum is ... [more ▼]

A theoretical study of optical absorption and emission measurements of Fe2+ as a substitutional impurity in InP and GaP is presented. A new interpretation of the low-temperature absorption spectrum is proposed based on a weak Jahn-Teller interaction between the electronic excited states and a local gap mode of Gamma(5) symmetry. The model also includes the crystal potential, hybridization with the orbitals of the ligands of the host crystal, spin-orbit interaction and a weak dynamic Jahn-Teller coupling of the orbital ground state of Fe2+ with transverse acoustic phonons of Gamma(3) symmetry. The theoretical model describes with good accuracy the measured positions and relative intensities of the spectral lines. In addition, the mass dependence of the local gap mode of Gamma(5) symmetry reproduces the general features of the fine structures associated with the isotopic shifts of the zero-phonon line and the contribution to the isotopic shifts arising from the difference in zero-point energy between the initial and final states of the transition is evaluated. [less ▲]

Detailed reference viewed: 57 (8 ULg)
Peer Reviewed
See detailClinical impact and perspectives of 18F-FDG PET in lymphoma
Jerusalem, Guy ULg; Beguin, Yves ULg

in Clinical Lymphoma (2000), 1

Detailed reference viewed: 9 (6 ULg)
Full Text
Peer Reviewed
See detailCoumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
Pochet, Lionel; Doucet, Caroline; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry (2000), 8(6), 1489-1501

Detailed reference viewed: 36 (12 ULg)
Full Text
Peer Reviewed
See detailMethodological bias in home range and mobility estimates when locating radio-tagged trout, Salmo trutta, at different time intervals
Ovidio, Michaël ULg; Philippart, Jean-Claude ULg; Baras, Etienne

in Aquatic Living Resources (2000), 13(6), 449-454

Radio tracking has been extensively used to enhance our knowledge on the movement and home range of fish in general and salmonids in particular. However, the use of various temporal sampling protocols is ... [more ▼]

Radio tracking has been extensively used to enhance our knowledge on the movement and home range of fish in general and salmonids in particular. However, the use of various temporal sampling protocols is likely to overlook fish movements, and produce experimental artefacts, the amplitude of which is unknown and may compromise comparison of fish behaviours revealed by different protocols. Starting from a day-by-day tracking study of brown treat in Belgian waters (Aisne stream, nine fish, minimum 39 daily locations per fish), we re-examined their home range and mobility, through a subsampling process, as if the fish had been located at longer time intervals (2-14 days). The estimates from subsamples were compared to the original data set in order to quantify the corresponding reduction of accuracy from observed data, and how far this could be predicted on the basis of locating frequency. The results clearly indicate that all intervals longer than one day generally generate substantial biases (reduction of accuracy from 0 to 82% for home range and from 5 to 92% for mobility) but these can be partly corrected through the use of predictive models. This analysis demonstrates that any comparison between studies relying on different locating frequencies can generate some ambiguity when interpreting biological phenomena or geographical differences. (C) 2000 Ifremer/CNRS/INRA/IRD/Cemagref/Editions scientifrques et medicales Elsevier SAS. [less ▲]

Detailed reference viewed: 132 (5 ULg)
Full Text
See detailPreliminary survey of the palynological content of the Lower Devonian in the Oesling, Luxembourg
Steemans, Philippe ULg; Debbaut, Vincent ULg; Faber, A.

in Bulletin de la Société des Naturalistes Luxembourgeois (2000), 100

Detailed reference viewed: 14 (7 ULg)
Peer Reviewed
See detailEin Smiley für Roger : Ansätze zu einer vergleichenden Emoticographie
Vromans, Joseph ULg

in Equivalences (2000), 27/2-28/1

Detailed reference viewed: 22 (0 ULg)
See detailL'évaluation des compétences terminales. Synthèse de l'atelier langues modernes.
Delcomminette, Bernadette; Simons, Germain ULg

in Puzzle (2000), (9), 30-33

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailRelative Accuracy of the Identification of Ovarian Structures in the Cow by Ultrasonography and Palpation Per Rectum
Hanzen, Christian ULg; Pieterse, M.; Szenci, Otto et al

in Veterinary Journal (2000), 159(2), 161-170

Manual palpation or ultrasonographic examination of the cow's genital tract are currently used by veterinarians involved in reproductive management, but knowledge of the potential and the limitations of ... [more ▼]

Manual palpation or ultrasonographic examination of the cow's genital tract are currently used by veterinarians involved in reproductive management, but knowledge of the potential and the limitations of both methods is important to obtain an optimal accuracy in the diagnosis of physiological and pathological ovarian structures. This review presents the main features of manual and ultrasonographic characteristics of follicles, corpora lutea (with or without a cavity), follicular and lutenized cysts and the reliability of the two methods is compared. Manual diagnosis of follicles <10 mm is rather inaccurate, but ultrasound offers the possibility to diagnose follicles <5 mm and to measure their inner diameter. The predictive values of the presence or absence of a corpus luteum as determined by palpation are similar (78 vs. 75%). Manual or ultrasonographic diagnosis of the growing or regressing corpus luteum is rather difficult. The positive predictive value of a mature corpus luteum diagnosed by ultrasonography is lower (87%) than the negative predictive value (92%). Compared to manual palpation, ultrasonography permits a better estimation of the number and to determine more precisely the size of the mature corpus luteum. The positive values for follicular cysts diagnosed by palpation or by ultrasonography are 66 and 74% respectively, and for luteal cysts, the values are 66 and 85%, respectively. Manual palpation or ultrasonography are useful tools to diagnose ovarian structures in the cow. The accuracy of such methods can be enhanced by securing information on the reproductive history of the animal, palpation of uterine horns, vaginal examination or progesterone determinations. [less ▲]

Detailed reference viewed: 52 (5 ULg)
Full Text
Peer Reviewed
See detailCharacterization Of The Lipid-Binding Properties And Lipoprotein Lipase Inhibition Of A Novel Apolipoprotein C-Iii Variant Ala23thr
Liu, Hq.; Labeur, C.; Xu, Cf. et al

in Journal of Lipid Research (2000), 41(11), 9201-12

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated ... [more ▼]

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated in lipid binding (L9T/T20L, F64A/W65A) or LPL inhibition (K21A), were compared. Relative lipid binding efficiencies to dimyristoylphosphatidylcholine (DMPC) were L9T/T20L > WT >K21A > F64A/W65A with an inverse correlation with size of the discoidal complexes formed. Physicochemical analysis (Trp fluorescence, circular dichroism, and GdnHCl denaturation) suggests that L9T/T20L forms tighter and more stable lipid complexes with phospholipids, while F64A/W65A associates less tightly. Lipid displacement properties were tested by gel-filtrating apoE:dipalmitoylphosphatidylcholine (DPPC) discoidal complexes mixed with the various apoC-III variants. All apoC-III proteins bound to the apoE:DPPC complexes; the amount of apoE displaced from the complex was dependent on the apoC-III lipid binding affinity. All apoC-III proteins inhibited LPL in the presence or absence of apoC-II, with F64A/W65A displaying the most inhibition, suggesting that apoC-III inhibition of LPL is independent of lipid binding and therefore of apoC-II displacement. Taken together. these data suggest that the hydrophobic residues F64 and W65 are crucial for the lipid binding properties of apoC-III and that redistribution of the N-terminal helix of apoC-III (L9T/T20L) enhances the stability of the lipid-bound protein, while LPL inhibition by apoC-III is likely to be due to protein:protein interactions. [less ▲]

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailRetrospective study of 206 cases of surgical intestinal pathologies in the horse : incidence, diagnosis, prognosis and complications.
Grulke, Sigrid ULg; Gangl, Monika; Caudron, Isabelle et al

in Annales de Médecine Vétérinaire (2000), 144

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation ... [more ▼]

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation obstructions. The remaining 100 cases (48,5 %) are large intestine obstructions with 45 (45 %) strangulation obstructions. The global survival rate is of 51,5 %, of 42,2 % for small intestine and of 61 % for large intestine. A gravity and a shock score permit to define the prognosis before the decision for surgery. The incidence of the postoperative complications is higher (55,2 %) and the time for recovery is significantly longer for small intestinal pathologies than for large intestine affections. Shock and paralytic ileus are the most frequent complications accounting for 65 % of post operative mortalities. The survival rates are significantly different according to gravity and shock score. The time of recovery is also significantly different in function of the shock score. These findings show the importance of rapid diagnosis of the acute abdominal disease in order to improve the outcome. [less ▲]

Detailed reference viewed: 49 (17 ULg)
Full Text
Peer Reviewed
See detailMeasurements of hindlimb blood flow recorded using Doppler ultrasound during administration of vasoactive agents in halothane-anesthetized horses
Raisis, Anthea L; Young, Lesley E; Meire, Hylton B et al

in Veterinary Radiology & Ultrasound : The Official Journal of the American College of Veterinary Radiology & the International Veterinary Radiology Association (2000), 41(1), 64-72

The purpose of the study was to determine the ability of Doppler ultrasound to detect changes in femoral blood flow during pharmacologic manipulation of arterial blood pressure. Doppler ultrasonography ... [more ▼]

The purpose of the study was to determine the ability of Doppler ultrasound to detect changes in femoral blood flow during pharmacologic manipulation of arterial blood pressure. Doppler ultrasonography was performed in the femoral vessels of six halothane-anesthetized horses before and during administration of phenylephrine HCI and sodium nitroprusside. The time-averaged mean velocity and volumetric flow were calculated. The contour of the velocity waveform was assessed, and the early diastolic deceleration slope (EDDS) and pulsatility index (PI) were calculated. Administration of phenylephrine HCI resulted in increased mean aortic blood pressure (MABP) by 40% (29.3-53.0%). This caused significant decrease in cardiac output (26.8 to 13.5 l/min), femoral arterial velocity (left artery 7.20 to 4.00 cm/s; right artery 5.01 to 3.39 cm/s) and volumetric flow (left artery 556 to 221 ml/min; right artery 397 to 193 ml/min) in the femoral vessels and significant increase in systemic vascular resistance (163 to 433 dyn-s/cm5), EDDS (1a: 285 to 468: ra: 250 to 481) and PI (1a: 9.38 to 20.4; ra 17.1 to 29.1). Administration of sodium nitroprusside resulted in a decreased MABP of 27.2% (22.5-33%). This increased cardiac output (20.8 to 32.4 L/min), however, no significant changes were observed in femoral blood flow. Despite obvious changes in the waveform contour, no significant change occurred in EDDS or PI. These results suggest that Doppler ultrasound may be useful for measuring femoral blood flow in anesthetized horses. However, waveform analysis appears to be limited when multiple changes occur in central and peripheral haemodynamics. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailBlood Oxygen Binding in Double-Muscled Calves and Dairy Calves with Conventional Muscle Conformation
Cambier, Carole ULg; Clerbaux, T.; Detry, B. et al

in American Journal of Veterinary Research (2000), 61(3), 299-304

OBJECTIVE: To assess in vivo blood oxygen binding in double-muscled calves and dairy calves with conventional muscle conformation. ANIMALS: 58 dairy and 48 double-muscled calves. PROCEDURE: Calves were ... [more ▼]

OBJECTIVE: To assess in vivo blood oxygen binding in double-muscled calves and dairy calves with conventional muscle conformation. ANIMALS: 58 dairy and 48 double-muscled calves. PROCEDURE: Calves were classified as neonatal (24 hours old) or older calves (2 to 26 days old). Venous and arterial blood samples were collected, and hemoglobin concentration, pH, PCO2, and PO2 were determined. Blood oxygen equilibrium curves (OEC) under standard conditions were constructed, and the oxygen exchange fraction (OEF) and the amount of oxygen released at the tissue level by 100 ml of blood (OEF Vol%) were calculated. RESULTS: In each breed, partial pressure of oxygen at 50% saturation of hemoglobin (P50) under standard conditions was significantly higher in older than in neonatal calves, indicating a right shift in OEC with age. Venous P50 was significantly lower in neonatal double-muscled calves than in neonatal dairy calves, but arterial and venous P50 were significantly higher in older double-muscled calves than in older dairy calves. In double-muscled, but not in dairy, calves, OEF was significantly higher in older than in neonatal calves. In neonatal calves, OEF Vol% was not significantly different between breeds, but OEF Vol% was significantly higher in older double-muscled calves than in older dairy calves. CONCLUSIONS AND CLINICAL RELEVANCE: The lower OEF in neonatal double-muscled calves, compared with dairy calves, could contribute to the higher sensitivity of double-muscled calves to hypoxia. Blood oxygen affinity decreased with age, but OEF and OEF Vol% were unchanged with age in dairy calves, whereas they increased with age in double-muscled calves [less ▲]

Detailed reference viewed: 35 (1 ULg)
Full Text
Peer Reviewed
See detailAffections cardiaques et intolérances à l'effort. 1-Les troubles du rythme.
Amory, Hélène ULg; Art, Tatiana ULg

in Pratique Vétérinaire Equine (2000), 32(Numéro Spécial), 71-78

Detailed reference viewed: 57 (11 ULg)
Full Text
Peer Reviewed
See detailD'un procès à l'autre - pour une esthétique des médias
Servais, Christine ULg

in Recherches en Communication (2000), 13

Detailed reference viewed: 62 (15 ULg)
Peer Reviewed
See detailGeochemistry of granitoids from the south Carpathians: A review
Berza, Tudor; Andar, Petre; Tatu, Mihai et al

in Anuarul Institutului Geologic al României (2000), 71

Detailed reference viewed: 46 (9 ULg)
Full Text
Peer Reviewed
See detailVariability of Doppler ultrasound measurements of hindlimb blood flow in conscious horses
Raisis, Anthea L; Young, L. E.; Meire, H. B. et al

in Equine Veterinary Journal (2000), 32(2), 125-132

Ultrasonography of the left and right femoral artery and vein was performed in 5 conscious horses. Velocity waveforms, recorded using low pulse repetition frequency, were used to calculate time-averaged ... [more ▼]

Ultrasonography of the left and right femoral artery and vein was performed in 5 conscious horses. Velocity waveforms, recorded using low pulse repetition frequency, were used to calculate time-averaged mean velocity (TAV), velocity of component a (TaVa), velocity of component b (TaVb) and volumetric flow. Waveform analysis included calculation of early diastolic deceleration slope (EDDS) and pulsatility index (PI) and subjective description of the waveform. Measurements were recorded at monthly intervals for 6 months. The repeated measurements were used to determine the within-horse variation. Horses were then anaesthetised with halothane and the same measurements recorded 60 min after induction. Differences between measurements recorded in conscious and anaesthetised horses were determined. Within-horse variability for diameters of femoral arteries and veins was small (CV<10%). Within variability for all other measurements was marked (CV>11%), with within-horse variability being the largest for femoral venous flow (CV>35%). Source of variability was measurement error and biological variation. Despite variability in conscious horses it was possible to detect changes in blood flow during anaesthesia. In the femoral arteries, volumetric flow was lower and EDDS and PI was higher in anaesthetised horses. In the femoral veins, volumetric flow was also lower in anaesthetised horses. Therefore Doppler ultrasound appears to be a useful technique for studying blood flow in conscious and anaesthetised horses [less ▲]

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailThe effect of PIT tags on growth and physiology of age-0 cultured Eurasian perch Perca fluviatilis of variable size
Baras, E.; Malbrouck, C.; Houbart, M. et al

in Aquaculture (2000), 185

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailA new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi.
Bompard-Gilles, C; Villeret, V; Davies, G J et al

in Structure (2000), 8(2), 153-62

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate ... [more ▼]

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate N-terminal amino acids with both D and L stereospecificity. The DmpA active form is an alphabeta heterodimer, which results from a putative autocatalytic cleavage of an inactive precursor polypeptide. RESULTS: The crystal structure of the enzyme has been determined to 1.82 A resolution using the multiple isomorphous replacement method. The heterodimer folds into a single domain organised as an alphabetabetaalpha sandwich in which two mixed beta sheets are flanked on both sides by two alpha helices. CONCLUSIONS: DmpA shows no similarity to other known aminopeptidases in either fold or catalytic mechanism, and thus represents the first example of a novel family of aminopeptidases. The protein fold of DmpA does, however, show structural homology to members of the N-terminal nucleophile (Ntn) hydrolase superfamily. DmpA presents functionally equivalent residues in the catalytic centre when compared with other Ntn hydrolases, and is therefore likely to use the same catalytic mechanism. In spite of this homology, the direction and connectivity of the secondary structure elements differ significantly from the consensus Ntn hydrolase topology. The DmpA structure thus characterises a new subfamily, but supports the common catalytic mechanism for these enzymes suggesting an evolutionary relationship. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailLes arcanes de la prescription de l'action publique
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

Detailed reference viewed: 17 (0 ULg)