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See detailFactor-XIIIa-positive dendrocytes in drug-induced toxic epidermal necrolysis (Lyell's syndrome): paradoxical activation in skin and rarefaction in lymph nodes.
Paquet, Philippe ULiege; Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 374-8

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease characterized by the extensive destruction of the epidermis contrasting with the discreteness of lymphoid cell ... [more ▼]

BACKGROUND: Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease characterized by the extensive destruction of the epidermis contrasting with the discreteness of lymphoid cell infiltration. The precise pathomechanism of the disease remains unclear. METHODS: Skin specimens and peripheral and thoracic lymph nodes (LNs) were collected from 2 TEN patients. They were examined by conventional histology and immunohistochemistry using antibodies directed to factor XIIIa (dermal dendrocytes), CD1a (Langerhans cells), CD15 (granulocytes), CD20 (B lymphocytes), CD45RO (activated T lymphocytes), CD68 (macrophages) and the proliferation marker Ki-67. LNs from patients with mycosis fungoides, from subjects dead from acute cardiac failure or traumatic injuries, as well as metastasis-free sentinel LNs of cutaneous melanoma served as positive and negative controls. RESULTS: TEN LNs showed absence of germinal centers but a moderate hyperplasia of the paracortical T cell zone. Immunohistochemistry did not reveal any distinctive aspect in LN cellular densities between TEN and other control conditions except for the factor-XIIIa+ dendritic cells which were dramatically reduced in numbers in TEN LNs. This rarefaction in LNs contrasted with the great number of these cells in the skin of the same patients. CONCLUSION: The structure of TEN LNs rules out the involvement of an antibody-mediated response. As dendritic factor-XIIIa+ cells are involved in most cutaneous T-cell-mediated responses, their depletion in TEN LNs could explain the sparse lymphoid cell infiltrate in lesional TEN skin. [less ▲]

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See detailMycoplasma bovis dans le complexe respiratoire bovin et propriétés de cyto-adhésion in vitro
Thomas, Anne; Dizier, Isabelle ULiege; Sachse, K. et al

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 267-272

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This ... [more ▼]

Mycoplasmas frequently infect cattle, causing especially respiratory diseases. Mycoplasma bovis is the most important pathogenic species in countries free of bovine contagious pleuropneumonia. This species was frequently isolated in Belgium from cattle with respiratory disease. Furthermore, associations were often observed with pasteurellas and bovine respiratory syncytial virus. Of these M. bovis isolates, many were resistant to several antimicrobial agents which are used in cattle practice, except to fluoroquinolones. Inasmuch the high frequency of M. bovis isolation and antibiotic resistances, it is very important to understand the pathogenicity of this bacteria in order to optimize prophylactic tools. Therefore, the study of the cytadherence of M. bovis is essential since it represents the first step of the bacterial infection. According to our experimental results, PG45 is not representative of field isolates because of its low adherence rates to various cell lines. This could be explained by the high number of subcultures of this pathogenic strain underwent since its first isolation, which sharply contrasts with other isolates. M. bovis adheres specifically to bovine bronchial epithelial cells in primary culture. Proteins such as variable surface proteins C and F are involved in this step as observed by decreased adherence rates after trypsinization of mycoplasma cells or addition of monoclonal antibodies. [less ▲]

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See detailProstaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.
Faveeuw, Christelle; Gosset, Philippe; Bureau, Fabrice ULiege et al

in European Journal of Immunology (2003), 33(4), 889-898

Prostaglandin (PG) D(2), and its metabolites, are known to be important mediators during acute and chronic inflammation. However, their functions during the early phases of the immune response are poorly ... [more ▼]

Prostaglandin (PG) D(2), and its metabolites, are known to be important mediators during acute and chronic inflammation. However, their functions during the early phases of the immune response are poorly documented. In the present study, we show that PGD(2 )inhibits, in a dose-dependent manner, the CD40- and LPS-induced secretion of the Th1-driving factor IL-12 by murine splenic dendritic cells (DC), the most potent antigen-presenting cells. The inhibition of IL-12 production is mediated only in part by the cell surface G alpha s protein-coupled D prostanoid receptor (termed DP1) but not by the G alpha i protein-coupled DP receptor, DP2. We show that recruitment of DP1 in DC results in the activation of a cyclic AMP/protein kinase A pathway that is partially responsible for the inhibition of IL-12 production. We also suggest that the DP1-independent effects exerted by PGD(2) on IL-12 production may be due to the action of ist PGJ(2), but not PGF(2)alpha, metabolites. Electrophoretic mobility shift assays demonstrated that PGD(2) affects NF-kappa B activation through (the) DP1-independent pathway(s). Together these data suggest that PGD(2), by interacting with DP1 and by binding to other target cellular proteins, may regulate immune responses by affecting IL-12 production in DC [less ▲]

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See detailFacteurs de virulence et propriétés spécifiques des souches invasives d'Escherichia coli : III) Production de toxines
Van Bost, S.; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2003), 147(5, OCT-NOV), 327-342

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their ... [more ▼]

Escherichia coli bacterial species is subdivided into several strains that are pathogenic for man and animals, on the basis of their specific properties and factors which are responsible for their pathogenic characters. The pathogenic strains are classically subdivided into strains with intestinal tropism (enterotoxigenic, enteropathogenic, enterohaemmorrhagic, verotoxigenic and enteroinvasive) and with extraintestinal tropism (uropathogenic and invasive). Invasive strains cause septicaemia and/or bacteraemia with localisations in different internal organs (systemic infections). If specific virulence properties and factors of strains with intestinal tropism are quite well known and described, those of strains with extraintestinal tropism are much less characterised, especially in animals. The purpose of this serie of review articles is to present the current knowledge on specific properties and factors of extraintestinal strains: adhesins and colonisation factors, transmucosal transfer and survival in blood and internal organs, toxicity. The fourth manuscript will deal with the invasive strains themselves, focusing on the necrotoxigenic strains. This third manuscript presents the current knowledge on toxins produced by invasive strains of E. coli: endotoxins, cytotoxic necrotising factors, cytolethal distending toxins and haemolytic toxins. [less ▲]

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; Portetelle, Daniel ULiege et al

in Yeast (Chichester, England) (2003), 20(S1),

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See detailQuantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus
Debier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et al

in Marine Ecology-Progress Series (2003), 247

PCB contamination was measured in the milk and serum of grey seal Halichoerus grypus mothers and in the serum of their pups sampled from 2 to 5 times between parturition and weaning on the Isle of May ... [more ▼]

PCB contamination was measured in the milk and serum of grey seal Halichoerus grypus mothers and in the serum of their pups sampled from 2 to 5 times between parturition and weaning on the Isle of May, Scotland, in 1998 and 2000. Blubber biopsies were also taken from the lactating females at early and late lactation in 2000. Concentrations of PCBs in milk stayed constant during the first part of lactation (0.31 +/- 0.17 mug g milk(-1)) and then increased at late lactation (0.67 +/- 0.42 mug g milk(-1)). Curiously, it did not follow the changes of milk lipid content, which increased at early lactation and then stayed constant until the end of the nursing period. As a result, even when expressed per unit of milk lipids, PCBs underwent a rise at the end of lactation. The changes in milk PCBs were accompanied by similar dynamics in maternal serum as well as in pup serum. Increased concentrations of PCBs at late lactation in serum and milk may be explained in part by the changes observed in maternal blubber. PCB levels increased significantly between early and late lactation in inner blubber, suggesting that PCBs are less easily mobilised from blubber than lipids. At late lactation, the retention capacity of the reduced blubber layer for PCBs might have reached its maximum. The mobilization of less polar lipids from blubber might also occur at this stage. In both cases, this could result in a higher mobilization of PCBs at this time. While inner blubber was significantly less concentrated than outer blubber at early lactation (1.26 +/- 0.72 mug g lipids(-1) in inner blubber vs 3.16 +/- 1.34 mug g lipids(-1) in outer blubber), these variations disappeared at late lactation (3.24 +/- 2.60 mug g lipids(-1) in inner blubber vs 3.59 +/- 1.46 mug g(-1) lipids in outer blubber). Newborn pups already had significantly higher serum levels of PCBs than their mothers, revealing an important placental transfer (11.9 +/- 7.0 ng ml serum(-1) in pups vs 6.7 +/- 3.5 ng ml serum(-1) in mothers). These differences were even greater in late lactation, due to the ingestion of milk (27.9 +/- 18.1 ng ml serum(-1) in pups vs 12.2 +/- 7.2 ng ml serum(-1) in mothers). As lactation progressed, PCB levels in pup serum increased exponentially as compared to the levels in the serum of their mothers. [less ▲]

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See detailProstaglandin D2 affects the maturation of human monocyte-derived dendritic cells: consequence on the polarization of naive Th cells.
Gosset, Philippe; Bureau, Fabrice ULiege; Angeli, Veronique et al

in Journal of Immunology (2003), 170(10), 4943-52

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2 ... [more ▼]

Among the factors produced at inflammatory sites and those capable of modulating dendritic cell (DC) functions, PGD(2) may be important in the outcome of immune responses. The biological roles for PGD(2) are in part effected through two plasma membrane G protein-coupled receptors: the D prostanoid (DP) receptor and the chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTH2). In this report, we studied the effects of PGD(2) and of its major physiological metabolite, 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), on the functions of human monocyte-derived DC. First, we show that PGD(2) exerts in vitro chemotactic effects on monocytes via CRTH2 activation while it inhibits the chemokine-driven migration of monocyte-derived DC through DP. We also report that PGD(2) and 15d-PGJ(2) alter the LPS- and allergen-induced DC maturation and enhance the CD80/CD86 ratio on mature DC in a DP- and CRTH2-independent manner. Moreover, PGD(2) and 15d-PGJ(2) strongly reduce the secretion of the Th1 promoting cytokine IL-12 and affect the synthesis of chemokines involved in Th1 cell chemotaxis, particularly CXCL10. Inhibition of cytokine/chemokine secretion implicates at least in part DP, but not CRTH2. The effects exerted by PGD(2) are associated with the phosphorylation of CREB, but do not parallel with the deactivation of the NF-kappa B and mitogen-activated protein kinase pathways. In contrast, 15d-PGJ(2) seems to target other cellular proteins. Finally, in a model of Th CD45RA(+) differentiation induced by allergen- and superantigen-pulsed DC, PGD(2) impacts on the orientation of the immune response by favoring a Th2 response [less ▲]

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See detailMosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype.
Smit, Maria; SEGERS, Karin ULiege; Carrascosa, Laura Garcia et al

in Genetics (2003), 163(1), 453-6

To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif ... [more ▼]

To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold-the alleged founder ram of the callipyge flock-is mosaic for this SNP virtually proves the causality of this SNP in the determinism of the callipyge phenotype. [less ▲]

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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailNa-23 2D 3QMAS NMR and Si-29, Al-27 MAS NMR investigations of Laponite and synthetic saponites of variable interlayer charge
Delevoye, Laurent; Robert, Jean-Louis; Grandjean, Jean ULiege

in Clay Minerals (2003), 38

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Yeast (2003), 20(S291),

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See detailIn vitro paradigms for the study of GnRH neuron function and estrogen effects.
Matagne, Valerie; LEBRETHON, Marie-Christine ULiege; Gerard, Arlette et al

in Annals of the New York Academy of Sciences (2003), 1007

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency ... [more ▼]

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency of GnRH secretion, the excitatory effect of glutamate, and the inhibitory or excitatory effect of GABA. Among the different paradigms, the fetal olfactory placode cultures exhibit the unique property of migration in vitro and may retain the capacity to undergo maturational changes in vitro. The short-term incubation of hypothalamic explants obtained at different ages enables one to study developmental changes as well. Estrogens may have important roles in the regulation of GnRH function and can act indirectly via the neighboring neuronal/glial apparatus and directly on GnRH neurons at the cell body and terminal levels. A direct effect is supported by the recent localization of ERalpha and ERbeta transcripts in GnRH neurons using most paradigms. Discrepant effects of estrogens on GnRH neurons were observed since GnRH biosynthesis is inhibited while GnRH secretion can be either stimulated, unaffected, or reduced. It is likely that the regulatory role of sex steroids including estradiol is very complex since it could involve direct and indirect effects on GnRH neurons through genomic and/or non-genomic mechanisms. [less ▲]

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See detailCommentaires sur la correction d'un travail écrit
Dumortier, Jean-Louis ULiege

in Puzzle (2003), 14

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See detailChemistry of silica at different concentrations of non-ionic surfactant solutions: Effect of pH of the synthesis gel on the preparation of mesoporous silicas
Léonard, Alexandre ULiege; Blin, J. L.; Jacobs, P. A. et al

in Microporous and Mesoporous Materials (2003), 63(1-3), 59-73

Ordered and disordered mesoporous silicas have been synthesized through an assembly of non-ionic decaoxyethylene cetyl ether [C 16(EO) 10] and a tetramethoxysilane silica source by variation of the pH ... [more ▼]

Ordered and disordered mesoporous silicas have been synthesized through an assembly of non-ionic decaoxyethylene cetyl ether [C 16(EO) 10] and a tetramethoxysilane silica source by variation of the pH value of the synthesis gel. The structure, texture and morphology of the mesoporous silicas, synthesized with concentrated and diluted surfactant solutions, have been discussed from the perspective of silica's chemistry upon a variation of pH values of the synthesis gel (micellar solution). With concentrated surfactant solutions (50 wt%), disordered compounds are obtained in a range of pH from 2.0 to 7.0 (micellar solution). As the pH increases, however, the pore size distributions (PSD) become broader and bimodality appears due to the micelle-templated silica (MTS) mesopores and openings arising from silica dissolution-reprecipitation processes. Also, the MTS pores expand due to a change in conformation of the surfactant hydrophilic head upon pH increase. On the other hand, diluted surfactant solutions (10 wt%) lead to ordered materials in a pH range from 2.0 to 7.0 (synthesis gel). The PSD remain very narrow but interparticular porosity appears and the morphologies undergo deep changes from toroids, gyroids and ropes to aggregates of very small particles with increasing pH. © 2003 Elsevier Inc. All rights reserved. [less ▲]

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See detailEnergy conservation and dissipation in mitochondria isolated from developing tomato fruit of ethylene-defective mutants failing normal ripening: the effect of ethephon, a chemical precursor of ethylene.
Navet, R.; Jarmuszkiewicz, W.; Almeida, A. et al

in Journal of Bioenergetics & Biomembranes (2003), 35(2), 157-168

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two ... [more ▼]

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two energy-dissipating systems exhibit large variations during tomato fruit development and ripening on the vine. It has been suggested that AOX and UCP could be responsible for the respiration increase at the end of ripening and that the cytochrome pathway could be implicated in the climacteric respiratory burst before the onset of ripening. In this study, the use of tomato mutants that fail normal ripening because of deficiencies in ethylene perception or production as well as the treatment of one selected mutant with a chemical precursor of ethylene have revealed that the bioenergetics of tomato fruit development and ripening is under the control of this plant hormone. Indeed, the evolution pattern of bioenergetic features changes with the type of mutation and with the introduction of ethylene into an ethylene-synthesis-deficient tomato fruit mutant during its induced ripening. [less ▲]

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See detailPostexposure management of hepatitis A, B or C: treatment, postexposure prophylaxis and recommendations
Delwaide, Jean ULiege

in Acta Gastro-Enterologica Belgica (2003), 66(3), 250-254

Although there is no consensus on the best management of acute hepatitis C or on optimal strategy of follow-up after potential contamination, certain guidelines can nevertheless be proposed for the care ... [more ▼]

Although there is no consensus on the best management of acute hepatitis C or on optimal strategy of follow-up after potential contamination, certain guidelines can nevertheless be proposed for the care of these patients in practice. It is now recommended that acute hepatitis C be treated by interferon monotherapy in the presence of a C viremia, detectable by polymerase chain reaction, and an elevation of the transaminases. The earlier the treatment is started after appearance of symptoms, the more effective it is. Management of a potentially contaminated individuals consists of screening for the C virus as early as the fifteenth day after the potentially contaminating act and, in the case of virus transmission, starting interferon treatment as soon as elevation of the transaminases appears. No special precautions are to be taken by the person potentially contaminated for avoiding possible secondary C virus transmission during the follow-up period. In the case of acute hepatitis B, antiviral treatment should not be started, in view of the high percentage of spontaneous recoveries and the potentially negative effect of treatment on the chances of spontaneous recovery. Post-exposure prophylaxis by anti-hepatitis B immunoglobin injections and/or vaccination should be considered after evaluation of the hepatitis B surface antigen status of the source and of the vaccination and vaccine-response status of the exposed person. The classic scheme for selecting the most appropriate postexposure prophylaxis is reminded. In post-exposure prophylaxis for hepatitis A virus, although there have been no studies comparing the effectiveness of vaccination with that of immunoglobin injections, it is at present proposed to provide only vaccination. The target groups eligible for post-exposure prophylaxis are evoked. [less ▲]

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See detailLe Robinier faux-acacia en Wallonie : utopie ou réalité? Premiers résultats
Fourbisseur, Anne; Devillet, Stéphane; Jourez, Benoît ULiege et al

in Forêt Wallonne (2003), (67), 12-23

Malgré son grand potentiel technologique et écologique, le Robinier faux-acacia (Robinia pseudacacia L.) est une essence sinon méconnue, du moins négligée en Région wallonne. Dans le contexte actuel où la ... [more ▼]

Malgré son grand potentiel technologique et écologique, le Robinier faux-acacia (Robinia pseudacacia L.) est une essence sinon méconnue, du moins négligée en Région wallonne. Dans le contexte actuel où la notion de gestion durable s’est imposée, certaines de ses propriétés, notamment écologiques, ouvrent la voie à une plus grande prise en considération de l’espèce. De plus, le robinier présente des caractéristiques remarquables, liées à sa vitesse de croissance et aux propriétés de son bois, et est susceptible, dans une certaine mesure, de trouver des débouchés très valorisants, par exemple dans des emplois réservés jusqu’à présent aux bois tropicaux. Cette essence mérite certainement un intérêt particulier, d’autant plus que la littérature ne présente pas d’argument précis en sa défaveur. La présence d’épines et la nécessité d’améliorer la morphologie de l’arbre ne sont certes pas des raisons suffisantes pour justifier l’absence d’expérimentation sylvicole en Région wallonne, mis à part les dispositifs installés voilà maintenant deux ans par l’Unité de Gestion des Ressources forestières et des Milieux naturels de la Faculté universitaire des Sciences agronomiques de Gembloux (FUSAGx) et par le Centre de Recherche de la Nature, des Forêts et du Bois, Direction de Technologie <br />du Bois (CRNFB, DTB). Un programme d’amélioration génétique pourrait en parallèle générer en quelques années un matériel de qualité en s’inspirant des recherches menées en Hongrie, pays à la pointe en matière de gestion du Robinier faux- acacia. Pour répondre à l’attente des estionnaires privés et publics, nous présentons une synthèse des connaissances relatives au robinier. Dans ce but, nous tenterons d’abord de cerner ses exigences stationnelles, et nous en déduirons les potentialités d’implantation de l’essence en Wallonie. Nous décrirons ensuite <br />la sylviculture appliquée au robinier en Hongrie et en France, pays réputés pour leur expérience dans le domaine, et verrons dans quelle mesure il est possible de profiter de cette expérience en Région wallonne. Nous détaillerons enfin les possibilités de valorisation de son bois. Les premiers résultats issus des dispositifs expérimentaux de sylviculture mis en place par la FUSAGx depuis <br />2 ans en Région wallonne seront inclus dans cet état des lieux et comparés aux expériences étrangères. [less ▲]

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See detailEnseigner autrement : une expérience à l’Université de Liège
Merenne-Schoumaker, Bernadette ULiege

in Géographes Associés (2003), (27), 183-184

Analyse d'une expérience en pédagogie active développée dans le cadre du cours de géographie urbaine à l'Université de Liège

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See detailFrom the germinal cells to the newborn animal: The transmission of genes and life through the generations
Drion, Pierre ULiege; Szenci, Otto; Ectors, Fabien ULiege et al

in Acta Veterinaria Hungarica (2003), 51(3), 371-384

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most ... [more ▼]

The technology of reproduction progressed considerably during the last decade, leading to a certain availability of in vitro methods for fertilisation, oocyte maturation and embryo culture. The most spectacular manipulations are cloning and transgenesis. This review focuses on the early appearance of germinal cell precursors and the long-standing fate of gametes in mammals. The evident complexity and long-term programming of events in gametes and early embryos explain part of the difficulties encountered during the development of in vitro and in vivo methods such as multiple Ovulation and embryo transfer (MOET), oestrus synchronisation, ovulation induction, superovulation, in vitro maturation and fertilisation, cryopreservation, transgenesis, nuclear transfer and cloning) and the occurrence of unexpected alterations of development, e.g. embryonic or fetal mortality, large-weight newborn syndrome and other dysregulations ill imprinting or DNA transmission. [less ▲]

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See detailHorizontal And Vertical Co2 Advection In A Sloping Forest
Aubinet, Marc ULiege; Heinesch, Bernard ULiege; Yernaux, Michel ULiege

in Boundary-Layer Meteorology (2003), 108(3),

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See detailPetrogenesis of jotunitic and acidic members of an AMC suite (Rogaland anorthosite province, SW Norway): a Sr and Nd isotopic assessment
Bolle, Olivier ULiege; Demaiffe, Daniel; Duchesne, Jean-Clair ULiege

in Precambrian Research (2003), 124(2-4), 185-214

Sr and Nd isotopic data from the anorthosite-mangerite-charnockite (AMC) suite of the Late-Sveconorwegian (ca. 0.93 Ga) Rogaland anorthosite province of SW Norway are discussed. The study focuses on new ... [more ▼]

Sr and Nd isotopic data from the anorthosite-mangerite-charnockite (AMC) suite of the Late-Sveconorwegian (ca. 0.93 Ga) Rogaland anorthosite province of SW Norway are discussed. The study focuses on new data obtained from three distinct rock occurrences: (1) primitive (=MgO-rich and K2O-poor)jotunites that represent the parental magmas of leuconorite and mafic plutons (Sr-87/Sr-86(0.93Ga) = ca. 0.704-0.707, epsilon(Nd)(0.93 Ga) = +3.6 down to +1.2); (2) evolved jotunites that differentiated from the primitive jotunites and constitute the starting components of dyke-scale fractionation trends (Sr-87/Sr-86(0.93Ga) = ca. 0.705-0.713, epsilon(Nd)(0.93 Ga) = +0.4 down to -2.0); and (3) felsic plutons (Sr-87/Sr-86(0.93Ga) = ca. 0.707-0.723, epsilon(Nd)(0.93Ga) = +1.4 down to -1.7). A comparison of the Sr and Nd isotopic compositions with available geochemical data (major and trace elements) is also made. Fractionation of the primitive to the evolved jotunites, below the intrusion level of the anorthosite province, is shown to have involved crustal contamination. A case of fractional crystallization and simultaneous contamination/assimilation is substantiated in the felsic cap of a layered intrusion (the Bjerkreim-Sokndal intrusion). It is further proposed that the Sr and Nd isotopic compositions of the various felsic occurrences result from fractional crystallization of primitive jotunitic melts, with or without contamination/assimilation; this strengthens the possibility for large volumes of silica-rich magmas to have been produced by fractionation, through evolved jotunites, of primitive jotunites. The entire range in Sr and Nd isotopic compositions of the Rogaland anorthosite province is interpreted as reflecting a mixing of crustal contaminants, having variable Sr-87/Sr-86(0.93Ga) ratios and (negative) epsilon(Nd)(0.93 Ga) values, with a more isotopically primitive source. The crustal end members of that mixing array are represented by moderatey to strongly LILE-enriched high-grade gneisses from the Pre-Sveconorwegian basement of southernmost Norway, that have a crustal history extending back to 1.5-1.9 Ga in the surroundings of the anorthosite province. The primitive end member is either an unusual LREE-depleted and Rb-enriched component, possibly corresponding to an originally depleted source subsequently modified by metasomatic fluids, or a more classical depleted component; it corresponds to a gabbronoritic rock of the deep crust, as shown by recent experimental data, with a quite short crustal residence time (<0.4-0.2 Ga). If that mafic end member is the lower granulitic crust itself, this would imply the presence in the deep continental crust of southwesternmost Norway of a crustal material strongly different from the 1.7- to 1.9-Gyr-old, moderately LILE-enriched component that is supposed to constitute the largest volume of the present deep continental crust in southern Norway. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDéveloppement de modèles prédictifs des proportions de duramen et d'écorce des espèces de mélèze cultivées en zones de basse altitude en Europe de l'Ouest (Larix kaempferi (Lambert) Carr., Larix decidua Miller et Larix eurolepis Henry).
Pauwels, D.; Lejeune, Philippe ULiege; Paques, L. E. et al

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60(3), 227-235

Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way ... [more ▼]

Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way of applying them to European larch (Larix decidua Miller) and hybrid larch (Larix eurolepis Henry) growing in west-European lowlands. For the heartwood proportion, independent variables selected are stand age and dbh. The model set up for Japanese larch has a R-square of 0.859. In average, European larch has lower heartwood proportion. With reference to bark proportion, selected independent variable is dbh. Residual variability is far more important for bark models (R-square of 0.456). European larch has, in average, higher bark proportion whereas hybrid larch has lower. An example of the application of these models in connection with a growth model is presented. It consists in an evaluation of the impact of dynamic silviculture on heartwood and bark proportion. [less ▲]

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See detailThéorie économique et marchandisation des services non marchands
Mertens de Wilmars, Sybille ULiege; Lefebvre, Mathieu ULiege

in Non Marchand : Management, Droit et Finance (2003), (11), 11-27

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See detailNF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
Bentires-Alj, Mohamed; Barbu, Véronique; Fillet, Marianne ULiege et al

in Oncogene (2003), 22

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and ... [more ▼]

The ubiquitous NF-kappaB transcription factor has been reported to inhibit apoptosis and to induce drug resistance in cancer cells. Drug resistance is the major reason for cancer therapy failure and neoplastic cells often develop multiple mechanisms of drug resistance during tumor progression. We observed that NF-kappaB or P-glycoprotein inhibition in the HCT15 colon cancer cells led to increased apoptotic cell death in response to daunomycin treatment. Interestingly, NF-kappaB inhibition through transfection of a plasmid coding for a mutated IkappaB-alpha inhibitor increased daunomycin cell uptake. Indeed, the inhibition of NF-kappaB reduced mdr1 mRNA and P-glycoprotein expression in HCT15 cells. We identified a consensus NF-kappaB binding site in the first intron of the human mdr1 gene and demonstrated that NF-kappaB complexes could bind with this intronic site. Moreover, NF-kappaB transactivates an mdr1 promoter luciferase construct. Our data thus demonstrate a role for NF-kappaB in the regulation of the mdr1 gene expression in cancer cells and in drug resistance. [less ▲]

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See detailA new approach to the qualitative evaluation of functional disability in dementia
Kurz, Xavier; Scuvée-Moreau, Jacqueline ULiege; Rive, B. et al

in International Journal of Geriatric Psychiatry (2003), 18

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See detailFoam imbibition in microgravity - An experimental study
Caps, Hervé ULiege; Decauwer, H.; Chevalier, M. L. et al

in European Physical Journal B -- Condensed Matter (2003), 33(1), 115-119

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The ... [more ▼]

We report an experimental study of aqueous foam imbibition in microgravity with strict mass conservation. The foam is in a Hele-Shaw cell. The bubble edge width l is measured by image analysis. The penetration of the liquid in the foam, the foam imbibition, the foam inflation, and the rigidity loss are shown all to obey strict diffusion processes. The motion of bubbles needed for the foam inflation is a slow two-dimensional process with respect to the one-dimensional capillary rise of liquid. The foam is found to imbibes faster than it inflates. [less ▲]

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See detailCacophonie jurisprudentielle autour de la notion d’impôt
Rosoux, Géraldine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

The article analyzes a decision of the Belgian judicial Supreme Court concerning the concept of "tax", and emphasizes the conflict between this decision and the case-law of the Belgian constitutional Court

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See detailProlactin Suppresses Glucocorticoid-Induced Thymocyte Apoptosis in Vivo
Krishnan, Nithya; Thellin, Olivier ULiege; Buckley, Donna J. et al

in Endocrinology (2003), 144(5), 2102-2110

The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells ... [more ▼]

The hypothesis that prolactin (PRL) functions as an immunomodulator was based on studies showing lymphocyte PRL receptors, and its effects on growth, differentiation, and apoptosis in lymphoid cells. However, studies of PRL (PRL-/-) and PRL receptor knockout mice indicated that PRL was not required for immune system development or function under basal conditions. Because PRL maintains survival in glucocorticoid (GC)-treated Nb2-T lymphocytes in vitro, and PRL and GCs are elevated during stress, we investigated whether PRL protected T cells in vivo from GC-induced apoptosis. Adrenalectomized mice [PRL -/-, undetectable PRL; pituitary grafted PRL-/- (PRL-/-Graft), elevated PRL; and PRL+/-, normal PRL] were treated with dexamethasone (DEX) or PBS. Thymocytes and splenocytes were isolated and annexin V labeling of phosphatidylserine, DNA fragmentation, and caspase-3 activation were assessed as indices of apoptosis. Total thymocytes and CD4+ and CD8+ T cells obtained from DEX-treated PRL-/- mice exhibited significantly increased annexin V binding. In contrast, binding was not altered by DEX in PRL-/-Graft thymocytes. In addition, DEX induced classic DNA fragmentation in PRL-/- thymocytes. Elevated serum PRL reduced this effect. Thymocytes from DEX-treated PRL-/- mice exhibited increased caspase-3 activation, which was inhibited in cells from PRL-/-Graft mice. Finally, elevated expression of X-linked inhibitor of apoptosis, XIAP, was observed in thymi from DEX-treated PRL -/-Graft mice. This is the first demonstration that elevated PRL antagonizes apoptosis in thymocytes exposed to GCs in vivo. These observations suggest that, under conditions of increased GCs, such as during stress, elevated PRL functions physiologically to maintain survival and function of T-lymphocytes. [less ▲]

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See detailEffect of pressure and temperature upon tin alkoxide-promoted ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide
Stassin, Fabrice; Jérôme, Robert ULiege

in Chemical Communications (2003), (2), 232-233

Ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide is slowed down by a carbonation reaction, resulting in a positive volume of activation and a higher energy of activation ... [more ▼]

Ring-opening polymerisation of epsilon-caprolactone in supercritical carbon dioxide is slowed down by a carbonation reaction, resulting in a positive volume of activation and a higher energy of activation as compared to polymerisation in a regular hydrocarbon solvent. [less ▲]

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See detailGrowth hormone (GH) secretion in patients with childhood-onset GH deficiency: Retesting after one year of therapy and at final height
Thomas, Muriel; Massa, Guy; Maes, Maes et al

in Hormone Research (2003), 59(1), 7-15

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after ... [more ▼]

Background. Recent studies have shown that many patients treated with growth hormone (GH) during childhood because of idiopathic GH deficiency (GHD) are no longer GH deficient when retested after cessation of GH therapy when final height is achieved. These patients are labelled as transient GHD. We hypothesized that normalization of GH secretion in transient GHD could occur earlier during the course of GH treatment, which could allow earlier cessation of GH treatment. Methods: In a retrospective study, GH secretion was re-evaluated after cessation of GH treatment at final height in 43 patients diagnosed during childhood as idiopathic GHD 10 with multiple pituitary hormonal deficiencies (MPHD) and 33 with isolated GHD ([sGHD]). In a prospective study, GH secretion was re-assessed after interruption of GH treatment given for 1 year in 18 children with idiopathic GHD (2 MPHD, 16 IsGHD). GH secretion was evaluated by glucagon or insulin stimulation tests. Results: In the retrospective study, all the 10 patients with MPHD and 64% of the 33 patients with IsGHD were still deficient at re-evaluation using the paediatric criteria to define GHD (GH peak < 10 ng/ml at provocative test). The proportion of persisting deficiency was greater in patients with complete IsGHD (86%, 12/14 patients) than in patients with partial IsGHD (47%, 9/19 patients). With the criteria proposed in adulthood (GH peak <3 ng/ml), all the 10 patients with MPHD were still considered to be deficient. In contrast, only 15% (5/33 patients) with IsGHD had a maximal GH value < 3 ng/ml (36% of the 14 patients with complete IsGHD and none of the 19 patients with partial IsGHD). In the prospective study, after interruption of GH therapy given for 1 year, the 2 patients with MPHD were still GHD at re-evaluation and they resumed GH treatment. Among the 16 patients with IsGHD, 13 (81%) were still deficient (peak response < 10 ng/ml) after 1 year. Two of the 3 patients in whom GHD was not confirmed at retesting after 1 year GH showed again a deficient response at second retesting. Conclusions: Although many patients diagnosed with IsGHD during childhood have a normalized GH secretory capacity when retested during adulthood, early retesting after interruption of GH treatment given for 1 year during childhood does not enable to determine if GH therapy has to be discontinued before cessation of growth. Copyright (C) 2003 S. Karger AG, Basel. [less ▲]

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See detailOntogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
Tirelli, Ezio ULiege; Laviola, Giovanni; Adriani, Walter

in Neuroscience & Biobehavioral Reviews (2003), 27(1-2), 163-178

The present review deals mainly with the ontogenesis of two important phenomena involved in vulnerability to several neuropsychiatric disorders, namely with drug-induced sensitization (both contextual and ... [more ▼]

The present review deals mainly with the ontogenesis of two important phenomena involved in vulnerability to several neuropsychiatric disorders, namely with drug-induced sensitization (both contextual and non-contextual) and with conditioned place preference. The term 'infancy' covers the first three postnatal weeks during development in rats and mice. Conversely, the term 'adolescence' may cover the whole postnatal period ranging from weaning (PND 21) to adulthood (at least PND 60) or specifically the period around the onset of puberty (animals aged 33-44 days). Recent studies in rats demonstrated that the establishment of a context-dependent sensitization appears during the first (for repeated drug administration) or during the second (for a single drug administration) postnatal week. However, the memory of drug-context association is transient in developing pups (lasting one or two days following the drug pretreatment). The long-term retention of drug-context associations matures progressively, and is complete by the third week of postnatal life. Finally, those mechanisms responsible for an adult-like profile of context-independent pharmacological sensitization appear later during ontogenesis, being mature by the fourth week of postnatal life. Another set of experiments extended this ontogenetic characterization by comparing adolescent and adult mice. When compared to the latter, the former subjects exhibit a greater amphetamine-induced locomotor sensitization, almost no sensitization of aversive stereotyped behaviors, and a less marked place conditioning. The strength of the drug-induced place conditioning was also directly compared with the unconditioned novelty-seeking drive. In conclusion, neonatal rats are able to show a relatively short-lasting retention of sensitized drug effects (short-term sensitization), whereas the ability to exhibit relatively long-lasting sensitized effects matures progressively during infancy (long-term sensitization). On the other hand, adolescent mice show a reduced sensitization of drug-induced psychotic symptoms, together with a more marked sensitization of arousing and euphorigenic properties of the drug and a reduced incentive memory of its hedonic effects. These age-related changes do imply very different degrees of vulnerability to drug addiction and several other neuropsychiatric disorders. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPiracetam Inhibits The Lipid-Destabilising Effect Of The Amyloid Peptide A Beta C-Terminal Fragment
Mingeot-Leclercq, Mp.; Lins, Laurence ULiege; Bensliman, M. et al

in Biochimica et Biophysica Acta-Biomembranes (2003), 1609(1), 28-38

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta ... [more ▼]

Amyloid peptide (Abeta) is a 40/42-residue proteolytic fragment of a precursor protein (APP), implicated in the pathogenesis of Alzheimer's disease. The hypothesis that interactions between Abeta aggregates and neuronal membranes play an important role in toxicity has gained some acceptance. Previously, we showed that the C-terminal domain (e.g. amino acids 29-42) of Abeta induces membrane permeabilisation and fusion, an effect which is related to the appearance of non-bilayer structures. Conformational studies showed that this peptide has properties similar to those of the fusion peptide of viral proteins i.e. a tilted penetration into membranes. Since piracetam interacts with lipids and has beneficial effects on several symptoms of Alzheimer's disease, we investigated in model membranes the ability of piracetam to hinder the destabilising effect of the Abeta 29-42 peptide. Using fluorescence studies and 31P and 2H NMR spectroscopy, we have shown that piracetam was able to significantly decrease the fusogenic and destabilising effect of Abeta 29-42, in a concentration-dependent manner. While the peptide induced lipid disorganisation and subsequent negative curvature at the membrane-water interface, the conformational analysis showed that piracetam, when preincubated with lipids, coats the phospholipid headgroups. Calculations suggest that this prevents appearance of the peptide-induced curvature. In addition, insertion of molecules with an inverted cone shape, like piracetam, into the outer membrane leaflet should make the formation of such structures energetically less favourable and therefore decrease the likelihood of membrane fusion. [less ▲]

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See detailModèle de croissance pour les plantations de mélèzes.
Pauwels, D.; Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 87-97

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches ... [more ▼]

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches (Japanese, European and Hybrid larches) in 99 stands. It enables to predict tree circumference increment from circumference, dominant height, basal area, age and site index of stands. Estimating increments of 1283 larches in 48 stands has been used to validate the model that gives unbiased estimates of the increments (mean error = -0.002 cm with standard deviation of 0.60 cm). The mean absolute error of estimates is 0.46 cm.year-1. The model has also been tested to predict the increment of larches in French experimental plots having very different silvicultural treatments. The residues of these estimations depend on the stand basal area: the lesser the stand basal area, the higher the residues of the estimation. A correction factor, linked to basal area through a Bailey and Clutter curve, has been introduced to extend the validity of the model to stands with a basal area lower than 12 m2.ha-1. This factor does not affect the increment estimations if the stand characteristics are close to mean value of the sample used to build the model (correction factor close to 1). The introduction in the model of competition indexes distance dependant or site qualitative variables does not significantly improve the growth model. [less ▲]

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See detailRedefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae.
Sapunaric, Frédéric ULiege; Franssen, Christine; Stefanic, Patrick et al

in Journal of Bacteriology (2003), 185(20), 5925-35

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain ... [more ▼]

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain R40 of Enterococcus hirae was investigated by disruption or substitution of the corresponding pbp5 and psr genes by Campbell-type recombination. The resulting modifications were confirmed by hybridization and PCR. The low susceptibility of E. hirae to beta-lactams was confirmed to be largely dependent on the presence of PBP5. However, against all expectations, inactivation of psr in ATCC 9790 or complementation of R40 cells with psr did not modify the susceptibility to benzylpenicillin or the growth and cell autolysis rates. These results indicated that the psr gene does not seem to be involved in the regulation of PBP5 synthesis and consequently in beta-lactam resistance or in the regulation of cell autolysis in E. hirae. [less ▲]

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See detailThe new concept-temporary stents, an experimental study.
Kavteladze, Z. A.; Dundua, D. P.; Dondelinger, R. F. et al

in International Journal of Interventional Cardioangiology (2003), 1

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See detailDesioratadine: Safety and tolerability data in clinical practice
Borchard, U. H. J.; Daly, Adrian ULiege; Plenker, A.

in Journal of Allergy and Clinical Immunology (The) (2003), 111(1), 74

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See detailPrevention de la fracture de la hanche chez le sujet age: ou en sommes-nous en 2003?
Reginster, Jean-Yves ULiege; Lecart, Marie-Paule ULiege; Sarlet, Nathalie ULiege et al

in Revue Médicale de Liège (2003), 58(4), 183-90

Osteoporosis in very elderly subjects is now considered, in most developed and several developing countries as a major social, clinical and financial burden. While many compounds have been investigated in ... [more ▼]

Osteoporosis in very elderly subjects is now considered, in most developed and several developing countries as a major social, clinical and financial burden. While many compounds have been investigated in the prevention or treatment of spinal fractures, few of them have unequivocally demonstrated their ability to reduce the risk of non vertebral and more specifically hip fractures in the very elderly. This situation may seem highly paradoxical since hip fractures are unanimously considered to be the most dramatic and disabling consequence of osteoporosis. The present article reviews the current evidence available to justify anti-osteoporotic medications to be recommended to very elderly subjects, in the perspective of reducing their risk of appendicular fractures. [less ▲]

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See detailContre l'ankylose de l'imagination
Frankignoulle, Pierre ULiege; Bianchi, Michael

in A+ : Architecture in Belgium (2003), 181

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See detailRemarques sur l'élaboration de la conscience linguistique des Grecs
Rochette, Bruno ULiege

in Glotta : Zeitschrift für Griechische und Lateinische Sprache (2003), 79

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See detailFungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.
Francis, Frédéric ULiege; Marty-Detraves, Claire; Poincloux, Renaud et al

in European Journal of Cell Biology (2003), 82(10), 515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect ... [more ▼]

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the effects of XCL at the cellular level. Immunofluorescence microscopy studies revealed that XCL is rapidly internalized into small endocytic vesicles that further coalesce in the perinuclear region. We show that XCL is endocytosed by the clathrin-dependent pathway, and is delivered to late endosome/lysosome compartments. The internalization of XCL seems to be general since it occurs in different cell types such as insect (SF9) or mammalian (NIH-3T3 and Hela) cell lines. In the presence of XCL, the uptake of GFP and BSA is greatly enhanced, demonstrating that XCL facilitates endocytosis. Thus, XCL could serve as a delivery agent to facilitate the endocytosis of proteins that do not enter the cell alone. [less ▲]

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See detailThe Uses of Poxviruses as Vectors
Vanderplasschen, Alain ULiege; Pastoret, Paul-Pierre ULiege

in Current Gene Therapy (2003), 3(6), 583-95

Poxviruses have played an amazing role in the development of virology, immunology and vaccinology. In 1796, deliberate inoculation of cowpox virus to humans was proved by Dr. Edward Jenner to protect ... [more ▼]

Poxviruses have played an amazing role in the development of virology, immunology and vaccinology. In 1796, deliberate inoculation of cowpox virus to humans was proved by Dr. Edward Jenner to protect against the antigenically related smallpox virus (variola). This discovery founded the science of immunology and eventually led to smallpox eradication from the earth in 1980 after a world wide vaccination campaign with vaccinia virus (another poxvirus). Paradoxically, despite the eradication of smallpox, there has been an explosion of interest in vaccinia virus in the eighties. This interest has stemmed in part from the application of molecular genetics to clone and express foreign genes from recombinant vaccinia virus. The use of these recombinant vaccinia viruses as efficacious in vitro expression system and live vaccine has raised concerns about their safety. The work of the scientific community of the last 20 years has contributed to improve drastically the safety of poxvirus derived vectors. Firstly, the safety of vaccinia virus has been enhanced by production of genetically attenuated strains. Secondly, alternative poxvirus vectors, such as avipoxviruses, were proved to be extremely safe and efficacious non-replicating vectors when used in non avian species. In the present chapter, the basic concepts of poxvirus biology required to assess the safety of a poxvirus derived vector are provided. The principal poxvirus vectors available to date are described in regards to their biosafety. [less ▲]

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See detailLes groupes d'entraide ou l'émergence de dynamiques citoyennes
Biquet, Véronique ULiege

in Observatoire : Revue d'Action Sociale & Médico-Sociale (2003), 39

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles ... [more ▼]

L'article montre comment les groupes d'entraide peuvent constituer des lieux d'émergence de dynamiques citoyennes, en permettant qu'un pont soit crée entre l'espace privé des relations interpersonnelles et l'espace public des questions relatives à la cité. [less ▲]

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See detailUn cas peu connu de traduction du grec en latin : l'Asclepius du Corpus Hermeticum
Rochette, Bruno ULiege

in Cahiers du Centre Gustave Glotz (2003), 14

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See detailFraming the future of antifungals in atopic dermatitis.
Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 398-400

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In ... [more ▼]

Atopic dermatitis (AD) is a frequent chronic inflammatory skin disease. Some fungal colonization or infection of the skin may exacerbate AD severity, particularly the so-called head and neck variant. In addition, excessive intestinal colonization by Candida albicans may represent an additional triggering factor. Hence, there is a rationale to use antifungals in selected AD patients. Early trials with topical ketoconazole in head and neck AD showed a decrease in Malassezia colonization, but no significant improvement was observed in the clinical severity. In contrast, clinical improvement and decreased serum IgE were obtained in patients with positive Malassezia radioallergosorbent tests (RASTs) who were treated by oral ketoconazole. Some preliminary data suggested that oral itraconazole treatment in AD patients reduced the need for topical corticosteroids, provided clinical improvement particularly in head and neck AD, reduced the cutaneous and intestinal fungal colonization that may trigger AD, reduced the percentage of positive Malassezia cultures and demonstrated a decrease in C. albicans and Malassezia RAST values. Furthermore, beside its antifungal action, itraconazole in part relieves pruritus and inflammation. In conclusion, oral itraconazole treatment can alleviate AD severity in selected patients. Fluconazole is also effective. Further research is warranted to identify whether the load in skin surface fungal agents, the fungal RAST values and specific prick testing should be assessed in order to optimize the antifungal management in AD patients. [less ▲]

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See detailLa mesure du sentiment de compétence chez les aidants de patients déments
Vernooij-Dassen, M.; Kurz, Xavier; Scuvée-Moreau, Jacqueline ULiege et al

in Revue épidémiologique Santé publique (2003), 51

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See detailL'engagement dans la lecture chez les jeunes de 15 ans. Résultats de PISA 2000
Lafontaine, Dominique ULiege

in Caractères (2003), 13

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See detailCommunication, positionnement et GPS
Debouche, Charles ULiege

in Journal des Ingénieurs (Le) (2003), (87), 2-31

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See detailAn intervention study to enhance postoperative pain management.
Bardiau, Françoise ULiege; Taviaux, Nicole F; Albert, Adelin ULiege et al

in Anesthesia and Analgesia (2003), 96(1), 179-85

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery ... [more ▼]

This study, conducted before and after the implementation of an acute pain service (APS) in a 1000-bed hospital, describes the process of the implementation of an APS. The nursing, anesthesia, and surgery departments were involved. In this study we sought to evaluate the results of a continuous quality improvement program by defining quality indicators and using quality tools. A quality program in accordance with current standards of acute pain treatment (multimodal) was worked out to enhance pain relief for all surgical inpatients. A survey of nurses' knowledge with regard to postoperative pain was conducted, and a visual analog scale (VAS) was introduced to assess pain intensity. Both nurses and physicians became familiar with evidence-based guidelines concerning postoperative pain. The entire process was monitored in three consecutive surveys and enrolled 2383 surgical inpatients. Pain indicators based on VAS and analgesic consumption were recorded during the first 72 postoperative hours. After a baseline survey about current practices of pain treatment, a nurse-based, anesthesiologist-supervised APS was implemented. The improvement in pain relief, expressed as VAS scores, was assessed in two further surveys. A quality manual was written and implemented. A major improvement in pain scores was observed after the APS inception (P < 0.001). IMPLICATIONS: The implementation of an acute pain service, including pain assessment by a visual analog scale, standard multimodal pain treatment, and continuous quality evaluation, improved postoperative pain relief. Establishing teams of surgeons, anesthesiologists, and nurses is the prerequisite for this improvement. [less ▲]

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See detailPopulation Genetic Structure Of Wild Phaseolus Lunatus (Fabaceae), With Special Reference To Population Sizes
Zoro Bi, I.; Maquet, A.; Baudoin, Jean-Pierre ULiege

in American Journal of Botany (2003), 90(6), 897-904

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See detailThe lichen genus Caprettia Bat. & H. Maia
Sérusiaux, Emmanuël ULiege; Lücking, Robert

in Bibliotheca Lichenologica (2003), 86

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; De Nève, Nancy et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailAromatic Side-Chain Interactions In Proteins. Near- And Far-Sequence His-X Pairs
Meurisse, R.; Brasseur, Robert ULiege; Thomas, Annick ULiege

in Biochimica et Biophysica Acta-Proteins and Proteomics (2003), 1649(1), 85-96

Several studies have analysed aromatic interactions, involving mostly phenylalanine, tyrosine and tryptophan. Only a few studies have considered histidine as an interacting aromatic residue. An extensive ... [more ▼]

Several studies have analysed aromatic interactions, involving mostly phenylalanine, tyrosine and tryptophan. Only a few studies have considered histidine as an interacting aromatic residue. An extensive analysis of aromatic His-X interactions is performed here on a data set of 593 PDB structures: 68% of the histidine are involved in aromatic pairs and 1271 non-redundant His-X pairs were analysed. Thirty percent of these pairs involve an aromatic partner less than 6 apart in the sequence. These near-sequence pairs correspond to conformations which stabilise secondary structures, mainly alpha-helices when the residues are 4 apart and beta-strands when they are 2 apart in the sequence. The partners of the other His-X pairs (887, 70%) are more than 5 apart in the sequence. Of these far-sequence pairs, 35% bridge beta strands and only 9% helices. The near-sequence pairs are sterically constrained as supported by conformer distribution. The X partners of far-sequence His-X pairs are mainly "above" the histidine ring with tilted and normal rings, corresponding to a "T shape; face to edge" orientation. Phenylalanine, the only aromatic residue with no heteroatom, is a disfavoured partner, whereas histidine is the preferred one. Heteroatom-heteroatom interactions are favoured in near-sequence as well as in far-sequence His-His, His-Trp and His-Tyr pairs. [less ▲]

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See detailStromatopogon cladoniae sp. nova, a remarkable new lichenicolous coelomycete from Belgium
Diederich, Paul; Sérusiaux, Emmanuël ULiege

in Bibliotheca Lichenologica (2003), 86

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailEffect of rival males on the courtship of paedomorphic and metamorphic Triturus alpestris (Amphibia : Salamandridae)
Denoël, Mathieu ULiege

in Copeia (2003), 2003(3), 618-623

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and ... [more ▼]

Current theories on the alternative mating tactics suppose that individuals may opt for particular behavioral patterns depending of their morphological status. Facultative paedomorphosis in newts and salamanders is a suitable process to explore this question because it implies the coexistence of two different morphological morphs differing by the presence of gills and epigamic traits. The aim of this study was to find out whether paedomorphs and metamorphs use similar tactics to attract mates in the presence of a rival and whether there are differences in sexual activity and success between alternative morphs. Sexual interactions in triadic encounters were staged and analyzed in a standardized experimental design. The two kinds of males did not differ in terms of sexual activity, spermatophore deposition or female responsiveness. Both rival paedomorphic and metamorphic males exhibited sexual interference, but in most encounters, intruders just disturbed the courting pair. Sperm transfer success was lower in triadic encounters than in dyadic encounters. These results illustrate that intermorph breeding also occurs in the presence of competitors but that the success rate of the newts is considerably decreased in such competitive situations. Moreover, newts do not use alternative reproductive tactics depending on their status (i.e., paedomorph or metamorph). [less ▲]

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See detailAdherence to various host cell lines of Mycoplasma bovis strains differing in pathogenic and cultural features
Thomas, Anne; Sachse, Konrad; Dizier, Isabelle ULiege et al

in Veterinary Microbiology (2003), 91(2-3), 101-113

Mycoplasma bovis is known to be responsible for pneumonia and arthritis in calves, as well as mastitis in dairy cows. Despite clear evidence of its pathogenic potential, little is known about mechanisms ... [more ▼]

Mycoplasma bovis is known to be responsible for pneumonia and arthritis in calves, as well as mastitis in dairy cows. Despite clear evidence of its pathogenic potential, little is known about mechanisms of cytadherence and the molecular factors involved. The purpose of this work was to compare adherence rates of M. bovis field strains to different host cell lines and study the effects of cloning and sub-culturing M. bovis strains on their adherence properties. Eighteen metabolically labeled M. bovis strains isolated from different pathological backgrounds were examined in adherence trials using four different host cell lines, i.e. embryonic bovine lung (EBL), embryonic bovine trachea (EBTr), Madin Darby bovine kidney (MDBK) and rabbit kidney (RK) cells. Although large interstrain variations in adherence rates (3.4-19.1%) were measured they could not be correlated to the pathological background (pneumonia, arthritis or mastitis). Adherence rates to the fibroblast cell line (EBTr) were significantly lower than those to the three epithelial cell lines (EBL, MDBK and RK). The only non-pathogenic strain (221/89) exhibited lower adherence rates than three isolates from clinical mastitis. Interestingly, adherence rates were significantly reduced after in vitro passaging. In contrast, no effect of single cloning of strains on adherence was observed. There was no general correlation between expression of variable surface proteins (Vsps) as monitored by immunoblotting and adherence rates, although alterations in Vsp expression profiles were seen as a consequence of passaging. As there is probably a large number of adhesins, variable and non-variable, on the surface of M. bovis cells the issue is very complex, and the most active components have yet to be identified. [less ▲]

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne
Hebert, Jacques ULiege; Herman, Marc; Jourez, Benoît ULiege

in Forêt Wallonne (2003), 62

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See detailThe Prose Poem Now
Delville, Michel ULiege; Alkhateeb, Tahseen

in AL-QUDS Al-arabi (2003)

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See detailDesign and simulation of a solar dryer for agriculture products
Bennamoun, Lyes ULiege; Belhamri, Azeddine

in Journal of Food Engineering (2003), 59(2-3),

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See detailLes lignes de force de l'accord interprofessionnel pour 2003-2004
Michiels, Olivier ULiege

in Journal du Juriste (2003), 23

Plan: Les dispositions relatives aux groupes à risque et aux jeunes auxquels s'applique un parcours d'insertion; La convention de premier emploi; La prépension; Les cotisations et retenues sur les ... [more ▼]

Plan: Les dispositions relatives aux groupes à risque et aux jeunes auxquels s'applique un parcours d'insertion; La convention de premier emploi; La prépension; Les cotisations et retenues sur les avantages complémentaires. [less ▲]

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See detailLa conception d'une exposition : du schéma programmatique à sa mise en espace
Drouguet, Noémie ULiege; Gob, André ULiege

in Culture et Musées (2003), 2

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See detailWhat are the realistic hopes for stem cells in neurological diseases ?
Rogister, Bernard ULiege

in Bulletin de l'Académie Nationale de Médecine (2003), 158

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See detailSH2 domain containing inositol 5-phosphatases 1 and 2 in blood platelets: interaction and respective role in the control of phosphatidylinositol 3,4,5-trisphosphate levels
Giuriato, S.; Pesesse, X.; Bodin, S. et al

in Biochemical Journal (2003), 376

Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and ... [more ▼]

Src homology domain 2-containing inositol 5-phosphatases 1 and 2 (SHIP1 and SHIP2) are capable of dephosphorylating the second messenger PtdIns(3,4,5) P3 (phosphatidylinositol 3,4,5-trisphosphate) and interacting with several signalling proteins. SHIP1 is essentially expressed in haematopoietic cells, whereas SHIP2, a closely related enzyme, is ubiquitous. In the present study, we show that SHIP1 and SHIP2 are expressed as functional PtdIns(3,4,5) P3 5-phosphatases in human blood platelets and are capable of interacting when these two lipid phosphatases are co-expressed, either naturally (platelets and A20 B lymphoma cells) or artificially (COS-7 cells). Using COS-7 cells transfected with deletion mutants of SHIP2, we demonstrate that the Src homology domain 2 of SHIP2 is the minimal and sufficient protein motif responsible for the interaction between the two phosphatases. These results prompted us to investigate the relative importance of SHIP1 and SHIP2 in the control of PtdIns(3,4,5) P3 levels in platelets using homozygous or heterozygous SHIP1- or SHIP2-deficient mice. Our results strongly suggest that SHIP1, rather than SHIP2, plays a major role in controlling PtdIns(3,4,5) P3 levels in response to thrombin or collagen activation of mouse blood platelets [less ▲]

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See detailWhat are the realistic hopes for remyelinisation in the central nervous system ?
Rogister, Bernard ULiege

in Bulletin de l'Académie Nationale de Médecine (2003), 158

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See detailCes nombres que l'on dit "imaginaires".
Rosseel, H.; Schneider, Marguerite ULiege

in Petit X (2003), 63

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See detailSylviculture et qualité du bois de l'épicéa en Région wallonne. Recommandations pratiques - Cahier technique n°22
Hebert, Jacques ULiege; Herman, M.; Jourez, B.

in Forêt Wallonne (2003), (62), 10-13

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See detailNecrotizing varicella zoster virus folliculitis.
Nikkels, Arjen ULiege; Pierard, Gérald ULiege

in European Journal of Dermatology (2003), 13(6), 587-9

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented ... [more ▼]

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented with a single large infiltrated plaque on the abdomen. Although histology showed a necrotizing folliculitis surrounded by a dense perifollicular inflammatory infiltrate, the clinical presentation was not suggestive of folliculitis. Subtle cyto-histological clues for viral infection were suggested. Immunohistochemistry revealed the presence of VZV in the remnants of the follicular structures. This report underlines one of the protean clinical presentations of VZV skin infections and highlights the discreteness of typical VZV-related cyto-histological alterations. Complementary VZV identification methods such as immunohistochemistry, are helpful in order to increase the diagnostic accuracy of unusual VZV lesions. [less ▲]

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See detailCurrent management strategies for coexisting diabetes mellitus and obesity.
Scheen, André ULiege

in Drugs (2003), 63(12), 1165-84

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular risk factors associated with insulin resistance in obese individuals with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: (i) promoting weight loss, through lifestyle modifications (low-calorie diet and exercise) and antiobesity drugs (orlistat, sibutramine, etc.); (ii) improving blood glucose control, through agents decreasing insulin resistance (metformin or thiazolidinediones, e.g. pioglitazone and rosiglitazone) or insulin needs (alpha-glucosidase inhibitors, e.g. acarbose) in preference to agents stimulating defective insulin secretion (sulphonylureas, meglitinide analogues); and (iii) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. Whenever insulin is required by the obese diabetic patient after failure to respond to oral drugs, it should be preferably prescribed in combination with an oral agent, more particularly metformin or acarbose, or possibly a thiazolidinedione. When morbid obesity is present, both restoring a good glycaemic control and correcting associated risk factors can only be obtained through a marked and sustained weight loss. This objective justifies more aggressive weight reduction programmes, including very-low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and long-term strategy. [less ▲]

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See detailEffet des bordures de champs sur les populations de Chrysopes [Neuroptera: Chrysopidae] en cultures maraîchères
Mignon, Jacques ULiege; Colignon, Pierre; Haubruge, Eric ULiege et al

in Phytoprotection (2003), 84(2), 121-128

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and ... [more ▼]

Both diversity and density of lacewings depend on prey availability but also on plant composition near crops. The impact of field borders vegetation on abundance and diversity of Syrphidae and Coccinellidae is well known but very few studies have been realised to assess its effect on the abundance and diversity of Chrysopidae. In 2000 and 2001, the impact of adjacent habitats on lacewing populations was investigated in both carrot and broad bean open fields. Three types of field borders were selected: (1) set-asides mainly composed by Lolium perenne and Trifolium spp., (2) crops (wheat, beet or other vegetables) and (3) woody areas (mixture of Acer sp., Populus sp. and Salix sp.). Insects were caught using yellow pan traps. Chrysopidae populations were shown to be significantly lower in carrot and broad bean fields bordered with woodland. Lacewing and other Neuroptera species richness were always low and were discussed in relation with their role of pest predators associated with other aphidophagous insects. [less ▲]

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See detailA General Method for the Frequency Domain FE Modelling of Rotating Electromagnetic Devices
Gyselinck, J.; Vandevelde, L.; Dular, Patrick ULiege et al

in IEEE Transactions on Magnetics (2003), 39(3), 1147--1150

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See detailEu10Mn6Sb13: A new ternary rare-earth transition-metal
Holm, A. P.; Park, S. M.; Condron, C. L. et al

in Inorganic Chemistry (2003), 42(15), 4660-4667

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 ... [more ▼]

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 crystallizes in the monoclinic space group C2/m with a = 15.1791(6) Angstrom, b = 19.1919(7) Angstrom, c = 12.2679(4) Angstrom, beta = 108.078(1)degrees, Z = 4 (R1 = 0.0410, wR2 = 0.0920), and T = 90(2) K. The structure of Eu10Mn6Sb13 is composed of double layers of Mn-centered tetrahedra separated by Eu2+ cations. The double layers are composed of edge- and corner-sharing Mn-centered tetrahedra which form cavities occupied by Eu2+ cations and [Sb-2](4-) dumbbells. Linear [Sb-3](5-) trimers bridging two tetrahedra across the cavity are also present. Bulk susceptibility data indicate paramagnetic behavior with a ferromagnetic component present below 60 K. Temperature-dependent electrical resistivity measurements show semiconducting behavior above 60 K (E-a = 0.115(2) eV), a large and unusually sharp maximum in the resistivity at similar to40 K, and metallic behavior below 40 K. Eu-151 Mossbauer spectra confirm that the europium is divalent with an average isomer shift of -11.2(1) mm/s at 100 K; the spectra obtained below 40 K reveal magnetic ordering of six of the seven europium sublattices and, at 4.2 K, complete ordering of the seven europium sublattices. [less ▲]

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See detailVie, mort et résurgence du follicule pileux.
Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Skin (2003), 6

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See detailNew or interesting lichens and lichenicolous fungi from Belgium, Luxembourg and northern France. IX.
Sérusiaux, Emmanuël ULiege; Diederich, Paul; Ertz, Damien et al

in Lejeunia, Revue de Botanique (2003), 173

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See detailClimatic influence on black grouse population dynamic in Belgian Hautes-Fagnes.
Loneux, Michèle ULiege; Lindsey, James ULiege; Vandiepenbeeck, Marc et al

in Sylvia (2003), 39(supplement), 53-57

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See detailProtocole GPG et succès de reproduction
Hanzen, Christian ULiege; Boudry, B.; Bouchard, E.

in Point Vétérinaire (2003), 34(238, AUG-SEP), 50-54

In cows, an average success rate of 32% for artificial insemination is obtained using the ovulation synchronisation GPG protocol in cows. This percentage is similar to that obtained in the same conditions ... [more ▼]

In cows, an average success rate of 32% for artificial insemination is obtained using the ovulation synchronisation GPG protocol in cows. This percentage is similar to that obtained in the same conditions after insemination of observed heat (32.6%) and slightly better to that obtained after synchronisation of heat using one or two doses of PgF(2alpha) (26,9 and 28.8%). The protocol has a positive effect on fertility expressed as the percentage of gravid cows four months after calving. The protocol may cause early return to oestrus, either after the first injection of GnRH or after the PgF(2alpha) injection. In heifers, the protocol induces a shortening of the cycle, which suggests that further research is needed on the interval between injections. The protocol does not result in a higher percentage of multiple ovulation. Embryonic mortality is about 7%. [less ▲]

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See detailExcitability of visual V1-V2 and motor cortices to single transcranial magnetic stimuli in migraine: a reappraisal using a figure-of-eight coil.
Bohotin, V.; Fumal, Arnaud ULiege; Vandenheede, M. et al

in Cephalalgia : An International Journal of Headache (2003), 23(4), 264-70

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13 ... [more ▼]

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13) and in healthy volunteers (HV) (n = 33). Patients who had a migraine attack within 3 days before or after the recordings were excluded. All females were recorded at mid-cycle. Single TMS pulses over the occipital cortex elicited phosphenes in 64% of HV, 63% of MO and 69% of MA patients. Compared with HV, the phosphene threshold was significantly increased in MO (P = 0.001) and in MA (P = 0.007), but there was no difference between the two groups of migraineurs. The motor threshold tended to be higher in both migraine groups than in HV, but the differences were not significant. In conclusion, this study shows that two-thirds (64.86%) of patients affected by either migraine type present an increased phosphene threshold in the interictal period, which suggests that their visual cortex is hypoexcitable. [less ▲]

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See detailTowards a more versatile alpha-glucan biosynthesis in plants
Jacon, Géraldine ULiege

in Journal of Plant Physiology (2003)

During the last 10 years, the increased need for starches with novel properties has occupied the research community, and many efforts were concentrated on unraveling the starch bio- synthesis pathways ... [more ▼]

During the last 10 years, the increased need for starches with novel properties has occupied the research community, and many efforts were concentrated on unraveling the starch bio- synthesis pathways. The knowledge generated in these investigations was subsequently used to produce tailor-made starches in higher plants using recombinant DNA technology. Examples of starches with new functionalities are those with a modified degree of branching (Schwall et al. 2000, Shewma- ker et al. 1994, Kortstee et al. 1996) and the amylose-free starch (Visser et al. 1991a, Kuipers et al.1994), some of which hold potential for applications in the paper-, textile-, plastics-, food and pharmaceutical industry. The accumulation of more starch has also been an objective, but this will not be dis- cussed further here, (see: Slattery et al. 2000). In our laboratory, we have embarked on two generic tech- nologies with a very wide range of applicability: (i) introduction of new linkages types and structural elements using glu- cansucrases, and (ii) engineering granule-boundness by using microbial starch-binding domains (SBDs). It is expected that these technologies will contribute substantially to the biosynthesis of more versatile α-glucans in the near future, leading to starches with altered functionalities that cannot be obtained by conventional breeding. In this study recent developments in starch modification using heterologous expression of microbial genes will be reviewed, with emphasis on the potato plant. [less ▲]

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See detailCalculation of optical absorption spectra of hydrogenated Si clusters: Bethe-Salpeter equation versus time-dependent local-density approximation
Benedict, L. X.; Puzder, A.; Williamson, A. J. et al

in Physical Review. B : Condensed Matter (2003), 68(8), 85310-1-85310-85310-885310-85310-8

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE ... [more ▼]

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE) with a model dielectric function, and the time-dependent density-functional theory within the adiabatic local-density approximation (TDLDA). Single-particle states are obtained from local-density approximation (LDA) calculations and, for the BSE calculation, a quasiparticle gap correction is provided by quantum Monte Carlo calculations. We find that the exchange-correlation kernel of the TDLDA has almost no effect on the calculated spectra, while the corresponding attractive part of the electron-hole interaction of the BSE produces enhanced absorptive features at low energies. For the smallest cluster SiH 4, the two methods produce markedly different results, with the TDLDA spectra appearing closer to the experimental result. The gross features of the TDLDA and BSE spectra for larger clusters are however similar, due to the strong repulsive Coulomb kernel present in both treatments [less ▲]

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See detailApplications médico-légales de la loi du 26 juin 190
Boxho, Philippe ULiege

in Revue trimestrielle de droit familial (2003)

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See detailLarval development of Myzostoma cirriferum (Myzostomida)
Eeckhaut, I.; Fievez, Laurence ULiege; Muller, M. C.

in Journal of Morphology (2003), 258

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and ... [more ▼]

The larval development of Myzostoma cirriferum is described by means of SEM, TEM, and cLSM. It is similar to that of other myzostomids and includes three stages: the protrochophore, the trochophore, and the metatrochophore. The protrochophore is a ball-shaped larva present in culture from 18-48 h after egg laying. It has no internal organs and its body is made of three cell types: covering cells and ciliated cells that are external and surrounded by a cuticle, and resting cells that fill the blastocoel. The trochophore is a pear-shaped larva that develops 20-72 h after egg laying; the body includes the same three cell types as the previous stage. The metatrochophore is a pear-shaped larva that develops between 40 h and 14 days and is characterized by the presence of two bundles of four chaetae. When fully developed, the metatrochophore has a digestive system (made of a pharynx, an esophagus, and a blind digestive pouch), two pairs of protonephridia, and a nervous system composed of a supraesophageal ganglion, circumesophageal connectives, and dorsal and ventral nerves. Metamorphosis generally occurs 7 days after egg laying. At that time, the metatrochophore loses its chaetae and becomes pleated ventrally. This ultrastructural analysis suggests that chaetae and the five ventral longitudinal nerve cords of M. cirriferum metatrochophores are homologous structures to those observed in some polychaete trochophores. Coupled with recent phylogenetic analyses, where the Myzostomida are placed outside the Annelida, homologies between myzostomid and polychaete larvae support the view that a trochophore appeared early during the spiralian evolution [less ▲]

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See detailEffets de la réduction de doses de formulations d’insecticides et de fongicides sur l’auxiliaire non cible Episyrphus balteatus Degeer
Colignon, P.; Haubruge, Eric ULiege; Gaspar, C. et al

in Phytoprotection (2003), 84

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See detailHow do paedomorphic newts cope with lake drying?
Denoël, Mathieu ULiege

in Ecography (2003), 26(4), 405-410

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic ... [more ▼]

Paedomorphosis, in which adult individuals retain larval traits, is widespread in newts and salamanders. Most evolutionary models predict the maintenance of this life-history trait in favourable aquatic habitats surrounded by hostile terrestrial environments. Nevertheless, numerous ponds inhabited by paedomorphic individuals are unpredictable and temporary. In an experimental framework, I showed that paedomorphic newts were able to metamorphose and thus survive in the absence of water. However, the mere decrease of water level or the life space do not seem to induce metamorphosis in paedomorphs. On the contrary, drying up induces almost all individuals to move on land and after that to colonize other aquatic sites located nearby. Such terrestrial migrations allow survival in drying conditions without metamorphosis as long as the distances of terrestrial migration are short. These results are consistent with the presence of paedomorphs in drying ponds and are in favor of classic optimality models predicting metamorphosis in unfavorable environments. [less ▲]

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See detailThiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals
Makarchikov, Alexander F; Lakaye, Bernard ULiege; Gulyai, I. E. et al

in Cellular and Molecular Life Sciences : CMLS (2003), 60(7), 1477-1488

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain ... [more ▼]

In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain proteins. Here we show that ThTP exists not only in vertebrates but is present in bacteria, fungi, plants and invertebrates. Unexpectedly, we found that in Escherichia coli as well as in Arabidopsis thaliana, ThTP was synthesized only under particular circumstances such as hypoxia (E. coli) or withering (A. thaliana). In mammalian tissues, ThTP concentrations are regulated by a specific thiamine triphosphatase that we have recently characterized. This enzyme was found only in mammals. In other organisms, ThTP can be hydrolyzed by unspecific phosphohydrolases. The occurrence of ThTP from prokaryotes to mammals suggests that it may have a basic role in cell metabolism or cell signaling. A decreased content may contribute to the symptoms observed during thiamine deficiency. [less ▲]

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See detailRelevance of bone mineral density, bone quality and falls in reduction of vertebral and non-vertebral fractures.
Hanssens, L.; Reginster, Jean-Yves ULiege

in Journal of musculoskeletal & neuronal interactions (2003), 3(3), 189-93

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the ... [more ▼]

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the community within the next fifteen years. However, the most effective way of setting up such preventive strategies is not yet unequivocally defined. Low bone mass and microarchitectural damage of bone tissue may account for a large part of the epidemiology of vertebral fractures. Extraskeletal determinants, including low muscle strength, poor balance and gait, all resulting in an increased propensity to fall, also play a major role in the occurrence of hip fracture. Depending on the localization of the fractures, the relative importance of skeletal and extraskeletal risk factors can significantly differ. For prevention of vertebral fractures, drugs affecting bone mass and skeletal architecture may provide a substantial benefit while hip fracture prevention will be more successfully targeted by multi-faceted strategies concentrating not only on the skeletal dimension of the fracture but also aiming, either pharmacologically or through multi-intervention programs, at a reduction in the incidence and in the consequences of falls in the elderly. [less ▲]

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See detailEcoFerme: un logiciel d'évaluation environnementale de l'exploitation agricole
Debouche, Charles ULiege

in Les Nouvelles de l'été (2003), (3e trimetre), 14-15

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See detailL'image du mois. Un chancre mou.
Nikkels, Arjen ULiege; Arrese Estrada, Jorge ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(2), 64-6

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See detailProbing a molecular electronic transition by two-colour sum-frequency generation spectroscopy
Humbert, Christophe; Dreesen, Laurent ULiege; Nihonyanagi, S. et al

in Applied Surface Science (2003), 212–213

We demonstrate that a new emerging technique, two-colour sum-frequency generation (SFG) spectroscopy, can be used to probe the molecular electronic properties of self-assembled monolayers (SAMs). In the ... [more ▼]

We demonstrate that a new emerging technique, two-colour sum-frequency generation (SFG) spectroscopy, can be used to probe the molecular electronic properties of self-assembled monolayers (SAMs). In the CH spectral range (2800–3200 cm-1), we show that the sum-frequency generation signal of a porphyrin alkanethiol derivative adsorbed on Pt(1 1 1) reaches a maximum intensity at ~435 nm SFG wavelength. This wavelength corresponds to the porphyrin moiety specific p–p*$ molecular electronic transition which is called the Soret or B band. This resonant behaviour is not observed for 1-dodecanethiol SAMs, which are devoid of molecular electronic transition in the investigated visible spectral range. [less ▲]

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See detailGrown So Ugly : Frank Zappa’s Poetics of Orality
Delville, Michel ULiege

in Prague Literary Review (2003), 2

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See detailRosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo.
Pelat, Michel; Dessy, Chantal; MASSION, Paul ULiege et al

in Circulation (2003), 107(19), 2480-6

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse ... [more ▼]

BACKGROUND: Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse prognosis in cardiovascular diseases. We examined potential alterations in BPV and HRV in genetically dyslipidemic, apolipoprotein (apo) E-/-, and control mice and the effect of chronic statin treatment on these parameters in relation to their NO synthase (NOS)-modifying properties. METHODS AND RESULTS: BP and HR were recorded in unrestrained, nonanesthetized mice with implanted telemetry devices with or without rosuvastatin. Cardiac and aortic expression of endothelial NOS and caveolin-1 were measured by immunoblotting. Both systolic BP and HR were elevated in apoE-/- mice, with abolition of their circadian cycles. Spectral analysis showed an increase in their systolic BPV in the very-low-frequency (+17%) band and a decrease in HRV in the high-frequency (-57%) band, reflecting neurohumoral and autonomic dysfunction. Decreased sensitivity to acute injection of atropine or an NOS inhibitor indicated basal alterations in both parasympathetic and NOS regulatory systems in apoE-/- mice. Aortic caveolin-1 protein, an inhibitor of endothelial NOS, was also increased in these mice by 2.0-fold and correlated positively with systolic BPV in the very-low-frequency band. Rosuvastatin treatment corrected the hemodynamic and caveolin-1 expression changes despite persisting elevated plasma cholesterol levels. CONCLUSIONS: Rosuvastatin decreases caveolin-1 expression and promotes NOS function in apoE-/-, dyslipidemic mice in vivo, with concurrent improvements in BPV and HRV. This highlights the beneficial effects of rosuvastatin on cardiovascular function beyond those attributed to lipid lowering. [less ▲]

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See detailLe Droit des sociétés
Caprasse, Olivier ULiege

in Chronique de Droit à l'Usage du Notariat (2003)

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See detail'Aangewaaid uit een vreemd land': de westerse poëzie van G.J. Resink
Steyaert, Kris ULiege

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2003), 119(4), 279-299

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have ... [more ▼]

This article examines the critical response to the poetry of G.J. (Han) Resink (1911-1997), a Dutch-language poet and scholar who adopted the Indonesian nationality in 1950. In the past, commentators have very much focused on what they perceive to be 'eastern' elements in Resink's oeuvre. I maintain that this has resulted in a one-sided interpretation, neglecting the underlying western, and in particular Dutch, tradition in many of Resink's poems. This article demonstrates the different ways in which Resink drew on the principles and literary output of the Eighties Movement, and how his formal experiments gain in significance when set against the work of poets like Perk, Kloos, and Dèr Mouw. The general view on Resink's later work as being inferior to his earlier poetry is shown to be the result of unwarranted preconceptions. [less ▲]

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See detailMarocains de Belgique : du travailleur immigré au citoyen transnational
Bousetta, Hassan ULiege; Martiniello, Marco ULiege

in Hommes & Migrations (2003), 1242(Mars-Avril), 94-106

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See detailNote sur les hétéroptères des cultures maraîchères de plein champ
Colignon, P.; Francis, Frédéric ULiege; Haubruge, Eric ULiege

in Notes Fauniques de Gembloux (2003), 51

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See detailNasal aspergillosis associated with an impacted canine tooth in a Belgian shepherd dog
Saunders, J.; Clercx, Cécile ULiege; Zonderland, J.L. et al

in Vlaams Diergeneeskundig Tijdschrift (2003), 72(6), 396-398

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left ... [more ▼]

A 9-month-old Belgian shepherd dog was evaluated for chronic nasal discharge. Oral examination revealed the absence of the left upper canine tooth. Radiographs showed impaction of this tooth into the left nasal cavity with caudal displacement of the tooth root. Rhinoscopy demonstrated the presence of fungal colonies. The impacted tooth was surgically removed and the nasal cavity flushed with enilconazole 1%. No recurrence was observed during a follow-up period of two years. [less ▲]

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