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See detailMultiple uprising invasions of Pelophylax water frogs, potentially inducing a new hybridogenetic complex
Dufresne, Christophe; Denoël, Mathieu ULg; Di Santo, Lionel et al

in Scientific Reports (2017), 7

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to ... [more ▼]

The genetic era has revolutionized our perception of biological invasions. Yet, it is usually too late to understand their genesis for efficient management. Here, we take the rare opportunity to reconstruct the scenario of an uprising invasion of the famous water frogs (Pelophylax) in southern France, through a fine-scale genetic survey. We identified three different taxa over less than 200 km2: the autochthonous P. perezi, along with the alien P. ridibundus and P. kurtmuelleri, which have suddenly become invasive. As a consequence, the latter hybridizes and may now form a novel hybridogenetic complex with P. perezi, which could actively promote its replacement. This exceptional situation makes a textbook application of genetics to early-detect, monitor and understand the onset of biological invasions before they pose a continental-wide threat. It further emphasizes the alarming rate of amphibian translocations, both at global and local scales, as well as the outstanding invasive potential of Pelophylax aliens. [less ▲]

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See detailRéalisation du attelle de Thomas modifiée chez le bovin
Maquet, Celine ULg; Casalta, Hélène ULg; Sartelet, Arnaud ULg et al

in Point Vétérinaire (2017), 377

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See detailViolences conjugales : un dilemme pour la justice pénale ? Leçons d’une analyse des enregistrements statistiques effectués dans les parquets belges
Vanneste, Charlotte ULg

in Champ pénal/Penal field (2017), XIV

Drawing on the analysis of statistics regarding Intimate Partner Violence collected on a large scale at the level of the Belgian prosecutors’ offices, the article reveals a wide gap between the zero ... [more ▼]

Drawing on the analysis of statistics regarding Intimate Partner Violence collected on a large scale at the level of the Belgian prosecutors’ offices, the article reveals a wide gap between the zero tolerance rhetoric conveyed in the normative discourse and actual implementation, which is generally weak and showing divergent judicial practices in the field. Faced with this dilemma, the highly contestable impact of the zero tolerance policy observed in preventing recidivism offers a substantial argument to revisit the role of the criminal justice system in this area. [less ▲]

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See detailInfusion of mesenchymal stromal cells after deceased liver transplantation: A phase I-II, open-label, clinical study.
DETRY, Olivier ULg; VANDERMEULEN, Morgan ULg; DELBOUILLE, Marie-Hélène ULg et al

in Journal of Hepatology (2017), 67(1), 47-55

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the ... [more ▼]

BACKGROUND & AIM: Mesenchymal stromal cell (MSC) infusion could be a mean to establish tolerance in solid organ recipients. The aim of this prospective, controlled, phase-1 study was to evaluate the feasibility, safety and tolerability of a single infusion of MSCs in liver transplant recipients. METHODS: Ten liver transplant recipients under standard immunosuppression received 1.5-3x106/kg third-party unrelated MSCs on post-operative day 3+/-2, and were prospectively compared to a control group of 10 liver transplant recipients. As primary end-points, MSC infusional toxicity was evaluated, and infectious and cancerous complications were prospectively recorded until month 12 in both groups. As secondary end-points, rejection rate, month-6 graft biopsies, and peripheral blood lymphocyte phenotyping were compared. Progressive immunosuppression weaning was attempted from month 6 to 12 in MSC recipients. RESULTS: No variation in vital parameters or cytokine release syndrome could be detected during and after MSC infusion. No patient developed impairment of organ functions (including liver graft function) following MSC infusion. No increased rate of opportunistic infection or de novo cancer was detected. As secondary end-points, there was no difference in overall rates of rejection or graft survival. Month-6 biopsies did not demonstrate a difference between groups in the evaluation of rejection according to the Banff criteria, in the fibrosis score or in immunohistochemistry (including Tregs). No difference in peripheral blood lymphocyte typing could be detected. The immunosuppression weaning in MSC recipients was not successful. CONCLUSIONS: No side effect of MSC infusion at day 3 after liver transplant could be detected, but this infusion did not promote tolerance. This study opens the way for further MSC or Treg-based trials in liver transplant recipients. LAY SUMMARY: Therapy with mesenchymal stromal cells (MSCs) has been proposed as a mean to improve results of solid organ transplantation. One of the potential MSC role could be to induce tolerance after liver transplantation, i.e. allowing the cessation of several medications with severe side effects. This study is the first-in-man use of MSC therapy in 10 liver transplant recipients. This study did not show toxicity after a single MSC infusion but it was not sufficient to allow withdrawal of immunosuppression. [less ▲]

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See detailLe recours à l'arbitrage en matière de succession internationale ou la rencontre entre deux mondes qui s'ignorent
Wautelet, Patrick ULg

in Revue du Notariat Belge (2017), 143(3119), 378-405

L'arbitrage est-il possible et, si oui, dans quelle mesure, dans le domaine des successions internationales? Pour répondre à cette question, le texte prend appui sur le Règlement 650/2012. L’arbitrage ... [more ▼]

L'arbitrage est-il possible et, si oui, dans quelle mesure, dans le domaine des successions internationales? Pour répondre à cette question, le texte prend appui sur le Règlement 650/2012. L’arbitrage présente des avantages considérables pour régler les différends issus d’une suc- cession présentant une dimension internationale. Des obstacles importants peuvent néanmoins limiter, voire empêcher le recours à l’arbitrage en matière successorale. Sont abordées successivement dans cette contribution, les questions d'accès à l'arbitrage et de déroulement de l'arbitrage, en particulier sous l'angle du droit applicable à l'arbitrage successoral. Deux difficultés majeures seront examinées au titre des questions relatives à l'accès à l'arbitrage : la première tient à la possibilité pour une juridiction arbitrale de se prononcer sur les droits réservataires dont bénéficient certains proches du défunt, la seconde à la fragilité qui pèse sur le choix par un testateur de confier à une juridiction arbitrale la résolution des différends. [less ▲]

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See detailRéalisation du attelle de Thomas modifiée pour un membre antérieur
Maquet, Celine ULg; Casalta, Hélène ULg; Touati, Kamal ULg et al

in Point Vétérinaire (2017), 377

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See detailMapping degenerate vortex states in a kagomé lattice of elongated antidots via scanning Hall probe microscopy
Xue, Cun; Ge, Jun-Yi; He, An et al

in Physical Review. B : Condensed Matter (2017), 96

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe ... [more ▼]

We investigate the degeneracy of the superconducting vortex matter ground state by directly visualizing the vortex con gurations in a kagomé lattice of elongated antidots via scanning Hall probe microscopy (SHPM). The observed vortex patterns, at specifi c applied magnetic fi elds, are in good agreement with the confi gurations obtained using time-dependent Ginzburg-Landau (TDGL) simulation. Both results indicate that the long range interaction in this nano-structured superconductor is unable to lift degeneracy between different vortex states and the pattern formation is mainly ruled by the nearest neighbour interaction. This simpli cation allows the identi cation of a set of simple rules characterizing the vortex con gurations. We demonstrated that these rules can explain both the observed vortex distributions and the magnetic fi eld dependent degree of degeneracy. [less ▲]

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See detailThe European Union’s Ambition to Harmonize Rules to Counter the Abuse of Member States’ Disparate Tax Legislations
Docclo, Caroline ULg

in Bulletin for International fiscal documentation (2017)

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See detailViolences au sein des relations amoureuses des adolescents et jeunes adultes : une réalité à ne pas négliger
Glowacz, Fabienne ULg; Courtain, Audrey ULg

in Champ Pénal = Penal Field (2017), XIV

Au cours des dernières décennies, la violence conjugale a fait l’objet d’un intérêt majeur par la science et la société, donnant lieu à l’élaboration de textes légaux et à des stratégies judiciaires ... [more ▼]

Au cours des dernières décennies, la violence conjugale a fait l’objet d’un intérêt majeur par la science et la société, donnant lieu à l’élaboration de textes légaux et à des stratégies judiciaires, psycho-sociales et préventives spécifiques. Ces avancées ont été initiées par la mobilisation des mouvements féministes qui ont sensibilisé la société aux violences faites aux femmes, tout particulièrement la violence physique, pour ensuite également considérer différentes formes de violences. Ainsi, les recherches scientifiques et les politiques publiques se sont concentrées principalement sur les violences dans les couples entre partenaires adultes. La violence dans les relations amoureuses des adolescents et des jeunes adultes est peu envisagée à un niveau sociétal, alors que la recherche montre que différentes formes de violences sont présentes au sein de ces relations. Dans le cadre de cette contribution, nous proposons de développer sur base d’une revue de la littérature et de données d’enquêtes menées auprès d’adolescents et de jeunes adultes, les spécificités des violences au sein des relations amoureuses durant cette période de développement, leurs prévalences et les dynamiques en cours, ainsi que les iens entre attitudes et violences agies et subies dans les relations amoureuses. Les questions relatives à la bidirectionnalité et à la symétrie de la violence, débattues pour la violence conjugale, seront également discutées à la lumière des éléments émanant des recherches menées au niveau international et d’une enquête menée en Belgique. [less ▲]

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See detailFaire émerger les problèmes (présentation du dossier)
Gavray, Marc-Antoine ULg

in Diotime. Revue internationale de didactique de la philosophie (2017), 73

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See detailSpecular sets
Berthé, Valérie; De Felice, Clelia; Delecroix, Vincent et al

in Theoretical Computer Science (2017), 684

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See detailMIP-based constructive heuristics for the three-dimensional Bin Packing Problem with transportation constraints
Paquay, Célia ULg; Limbourg, Sabine ULg; Schyns, Michael ULg et al

in International Journal of Production Research (2017)

This article is about seeking a good feasible solution in a reasonable amount of computation time to the three-dimensional Multiple Bin Size Bin Packing Problem (MBSBPP). The MBSBPP studied considers ... [more ▼]

This article is about seeking a good feasible solution in a reasonable amount of computation time to the three-dimensional Multiple Bin Size Bin Packing Problem (MBSBPP). The MBSBPP studied considers additional constraints encountered in real world air transportation situations, such as cargo stability and the particular shape of containers. This MBSBPP has already been formulated as a Mixed Integer linear Programming problem, but as yet only poor results have been achieved for even fairly small problem sizes. The goal of the work this paper describes is to develop heuristics that are able to quickly provide good initial feasible solutions for the MBSBPP. Three methodologies are considered, which are based on the decomposition of the original problem into easier subproblems: the matheuristics Relax-and-Fix, Insert-and-Fix and Fractional Relax-and-Fix. They have been parametrised on real data sets and then compared to each other. In particular, two of these techniques show promising results in reasonable computational times. [less ▲]

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See detailIdentification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting.
Kanis, J.A.; Cooper, C.; Rizzoli, R. et al

in Osteoporosis International (2017), 28(7), 2023-2034

Summary: Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap ... [more ▼]

Summary: Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future research. Introduction: The purpose of the study was to review data on the identification and treatment of patients with osteoporosis at increased risk of fracture. Methods: Aworking group convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis met to review current data on the epidemiology and burden of osteoporosis and the patterns of medical management throughout Europe. [less ▲]

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See detailStochastic Inventory Routing for Perishable Products
Crama, Yves ULg; Rezaei Sadrabadi, Mahmood ULg; Savelsbergh, Martin et al

in Transportation Science (2017)

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit ... [more ▼]

Different solution methods are developed to solve an inventory routing problem for a perishable product with stochastic demands. The solution methods are compared empirically in terms of average profit, service level, and actual freshness. The benefits of explicitly considering demand uncertainty are quantified. The computational study highlights that in certain situations a simple ordering policy can already reach a very good performance, but that statistically and economically significant improvements are achieved when using more advanced solution methods. Managerial insights concerning the impact of shelf life and store capacity on profit are also obtained. [less ▲]

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See detailViolences conjugales et justice pénale: un couple à problémes ? Introduction au dossier
Glowacz, Fabienne ULg; Vanneste, Charlotte ULg

in Champ Pénal = Penal Field (2017), Vol. XIV | 2017

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See detailConsistency of spatiotemporal sound features supports the use of passive acoustics for long-term monitoring
Parmentier, Eric ULg; Di Iorio, Lucia; Picciulin, Marta et al

in Animal Conservation (2017)

Many studies stress the usefulness of fish calls as effective indicators of distinct species occurrence. However, most of these studies have been undertaken in a given area and during restricted periods ... [more ▼]

Many studies stress the usefulness of fish calls as effective indicators of distinct species occurrence. However, most of these studies have been undertaken in a given area and during restricted periods of time. There is a need to show passive acoustic monitoring is a reliable method to study vocal species over space and time. This study aims to use passive acoustic methods to follow the brown meagre Sciaena umbra at relevant temporal and spatial scales. Specimens of S. umbra were recorded in both aquarium and in the field. In situ recordings were made at two regions (Corsica and Sardinia) during four summers (2008–2012–2013–2015). Temporal and frequency parameters of the fish calls were collected by different teams and compared to test the ability to unequivocally identify the fish sound. The comparison between our data and the bibliography highlights the capability to identify S. umbra during a period of 17 years in different Mediterranean regions, clearly supporting the usefulness of acoustic monitoring to discover and protect aggregation sites of this endangered species. The sound producing mechanism in S. umbra consists of high-speed sonic muscles surrounding dorsally the posterior end of the swim bladder, which can explain the low acoustic variability that helps in the species identification. Similar mechanisms are found in other Sciaenidae, suggesting that a similar conclusion can be drawn for many other adult sciaenids that could be used as sentinel species. This study should be of high interest to policymakers and scientists because it shows passive acoustic can be confidently used in resource management. [less ▲]

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See detailA Theory of Soft Capture
Agrell, Per; Gautier, Axel ULg

in Scandinavian Journal of Economics (2017), 119(3), 571-596

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to ... [more ▼]

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to provide a signal for the type of a regulated firm. Only the firm can observe his type and the production of a correlated signal with a given accuracy is costly for the regulator. The firm can costlessly provide an alternative signal of lower accuracy that is presented to the regulator. In a self-enforcing equilibrium, the regulator transmits the firm-produced signal, internalizes its own savings in information cost and the firm enjoys higher information rents. The main feature of soft capture is that it is not based on a reciprocity of favors but on a congruence of interests between the firm and the regulator. [less ▲]

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See detailEnhancing erythritol productivity in Yarrowia lipolytica using metabolic engineering
Carly, Frédéric; Vandermies, Marie ULg; Telek, Samuel ULg et al

in Metabolic Engineering (2017), 42

Erythritol (1,2,3,4-butanetetrol) is a four-carbon sugar alcohol with sweetening properties that is used by the agrofood industry as a food additive. In this study, we demonstrated that metabolic ... [more ▼]

Erythritol (1,2,3,4-butanetetrol) is a four-carbon sugar alcohol with sweetening properties that is used by the agrofood industry as a food additive. In this study, we demonstrated that metabolic engineering can be used to improve the production of erythritol from glycerol in the yeast Yarrowia lipolytica. The best results were obtained using a mutant that overexpressed GUT1 and TKL1, which encode a glycerol kinase and a transketolase, respectively, and in which EYK1, which encodes erythrulose kinase, was disrupted; the latter enzyme is involved in an early step of erythritol catabolism. In this strain, erythritol productivity was 75% higher than in the wild type; furthermore, the culturing time needed to achieve maximum concentration was reduced by 40%. An additional advantage is that the strain was unable to consume the erythritol it had created, further increasing the process's efficiency. The erythritol productivity values we obtained here are among the highest reported thus far. [less ▲]

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See detailImaging of super-fast dynamics and flow instabilities of superconducting vortices
Embon, L.; Anahory, Y.; Jelic, Zeljko ULg et al

in Nature Communications (2017), 8

Quantized magnetic vortices driven by electric current determine key electromagnetic properties of superconductors. While the dynamic behavior of slow vortices has been thoroughly investigated, the ... [more ▼]

Quantized magnetic vortices driven by electric current determine key electromagnetic properties of superconductors. While the dynamic behavior of slow vortices has been thoroughly investigated, the physics of ultrafast vortices under strong currents remains largely unexplored. Here, we use a nanoscale scanning superconducting quantum interference device to image vortices penetrating into a superconducting Pb film at rates of tens of GHz and moving with velocities of up to tens of km/s, which are not only much larger than the speed of sound but also exceed the pair-breaking speed limit of superconducting condensate. These experiments reveal formation of mesoscopic vortex channels which undergo cascades of bifurcations as the current and magnetic field increase. Our numerical simulations predict metamorphosis of fast Abrikosov vortices into mixed Abrikosov-Josephson vortices at even higher velocities. This work offers an insight into the fundamental physics of dynamic vortex states of superconductors at high current densities, crucial for many applications. [less ▲]

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See detailRéalisation du attelle de Thomas modifiée pour un membre postérieur
Maquet, Celine ULg; Casalta, Hélène ULg; Touati, Kamal ULg et al

in Point Vétérinaire (2017), 377

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See detailA Receding Horizon Approach to Incorporate Frequency Support into the AC/DC Converters of a Multi-Terminal DC Grid
Papangelis, Lampros ULg; Panciatici, Patrick; Debry, Marie-Sophie et al

in Electric Power Systems Research (2017)

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter ... [more ▼]

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter, using local measurements only, and supporting frequency of the adjacent AC area after a significant disturbance. The new discrete control is combined with the existing DC voltage droop technique. The formulation, inspired of Receding Horizon Control, enables providing to the AC area the desired frequency support, while at the same time taking into account various constraints, such as maintaining the DC voltage between secure operating limits. Examples obtained from a test system with a five-terminal DC network connecting two asynchronous areas demonstrate the effectiveness and robustness of the proposed control scheme in various scenarios, with emphasis on component failures. [less ▲]

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See detailLa Legal Origins Theory : droit, économie, idéologie
Vandenbulke, Antoine ULg

in Revue Internationale de Droit Economique (2017), 1

The Legal Origins Theory argues that the legal origins of a state have a significant influence on its economic growth. This theory originated mainly and prospered in the field of company law. A group of ... [more ▼]

The Legal Origins Theory argues that the legal origins of a state have a significant influence on its economic growth. This theory originated mainly and prospered in the field of company law. A group of researchers has enquired about the degree of protection granted to minority shareholders in various states throughout the world. They concluded that states belonging to the legal family of common law granted the best protection, sourcing an efficient market and easing their economic growth. The Legal Origins Theory spread out widely and expanded to several other legal domains, while continuing to emphasize and highlight the efficiency of the common law. It was furthermore at the heart of the “Doing Business” reports of the World Bank. This theory has led to many critiques, which the present paper aims to show. Beyond this analysis and the review of criticisms, our study finally attempts to identify the philosophical assumptions that support the Theory of Legal Origins, through the review of the developments authored by Friedrich von Hayek and Bruno Leoni. [less ▲]

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See detailThe thermal structure of the Venus atmosphere: Intercomparison of Venus Express and ground based observations of vertical temperature and density profiles✰
Limaye, Sanjay S.; Lebonnois, Sebastien; Mahieux, Arnaud et al

in Icarus (2017), 294

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and ... [more ▼]

The Venus International Reference Atmosphere (VIRA) model contains tabulated values of temperature and number densities obtained by the experiments on the Venera entry probes, Pioneer Venus Orbiter and multi-probe missions in the 1980s. The instruments on the recent Venus Express orbiter mission generated a significant amount of new observational data on the vertical and horizontal structure of the Venus atmosphere from 40 km to about 180 km altitude from April 2006 to November 2014. Many ground based experiments have provided data on the upper atmosphere (90-130 km) temperature structure since the publication of VIRA in 1985. The "Thermal Structure of the Venus Atmosphere" Team was supported by the International Space Studies Institute (ISSI), Bern, Switzerland, from 2013 to 2015 in order to combine and compare the ground-based observations and the VEx observations of the thermal structure as a first step towards generating an updated VIRA model. Results of this comparison are presented in five latitude bins and three local time bins by assuming hemispheric symmetry. The intercomparison of the ground-based and VEx results provides for the first time a consistent picture of the temperature and density structure in the 40 km-180 km altitude range. The Venus Express observations have considerably increased our knowledge of the Venus atmospheric thermal structure above ∼40 km and provided new information above 100 km. There are, however, still observational gaps in latitude and local time above certain regions. Considerable variability in the temperatures and densities is seen above 100 km but certain features appear to be systematically present, such as a succession of warm and cool layers. Preliminary modeling studies support the existence of such layers in agreement with a global scale circulation. The intercomparison focuses on average profiles but some VEx experiments provide sufficient global coverage to identify solar thermal tidal components. The differences between the VEx temperature profiles and the VIRA below 0.1 mbar/95 km are small. There is, however, a clear discrepancy at high latitudes in the 10-30 mbar (70-80 km) range. The VEx observations will also allow the improvement of the empirical models (VTS3 by Hedin et al., 1983 and VIRA by Keating et al., 1985) above 0.03 mbar/100 km, in particular the 100-150 km region where a sufficient observational coverage was previously missing. The next steps in order to define the updated VIRA temperature structure up to 150 km altitude are (1) define the grid on which this database may be provided, (2) fill what is possible with the results of the data intercomparison, and (3) fill the observational gaps. An interpolation between the datasets may be performed by using available General Circulation Models as guidelines. An improved spatial coverage of observations is still necessary at all altitudes, in latitude-longitude and at all local solar times for a complete description of the atmospheric thermal structure, in particular on the dayside above 100 km. New in-situ observations in the atmosphere below 40 km are missing, an altitude region that cannot be accessed by occultation experiments. All these questions need to be addressed by future missions. [less ▲]

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See detailMacroevolutionary analysis of the tempo of diversification in snappers and fusiliers (Percomorpha: Lutjanidae)
Frederich, Bruno ULg; Santini, Francesco

in Belgian Journal of Zoology (2017), 147(1), 17-35

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are ... [more ▼]

The percomorph fish family Lutjanidae (snappers and fusiliers) includes about 135 reef-dwelling species, mainly confined to tropical and subtropical marine waters. The great majority of snappers are active predators feeding on fishes or crustaceans, even though some species, including the fusiliers (Caesioninae), have evolved zooplanktivory. Lutjanids show a great diversity of habitat preferences, based on depth segregation and distribution across reef and associated habitats (e.g. mangroves, seagrass beds, estuaries). In spite of their great ecological and economic importance little is known about the tempo of evolution in this group. The present study provides the most comprehensive molecular phylogeny to date for lutjanids, including 70% of extant species and 19 of the 21 currently described genera. We time-calibrated our molecular tree using the oldest described lutjanid fossils, and show how this group likely originated during the Late Cretaceous to Early Paleocene. Lutjanids experienced significant radiation during the Late Eocene and Early Oligocene, in contrast to a pattern of Late Oligocene/Miocene radiation observed in many other reef-associated groups. The time-tree allows us to investigate the tempo of diversification, and our results suggest a variation in the rate of speciation during the evolution of the major clade formed by “lutjanins and caesionins”. Variation in diet and life history strategies could explain this clade-specific dynamic, even though future phylogenetic comparative studies combining additional ecological and morphological data are needed to test this hypothesis. [less ▲]

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See detailNatural and induced loss of function mutations in SlMBP21 MADS-box gene led to jointless-2 phenotype in tomato
Gomez Roldan, Maria Victoria; Périlleux, Claire ULg; Morin, Halima et al

in Scientific Reports (2017), 7

Abscission is the mechanism by which plants disconnect unfertilized flowers, ripe fruits, senescent or diseased organs from the plant. In tomato, pedicel abscission is an important agronomic factor that ... [more ▼]

Abscission is the mechanism by which plants disconnect unfertilized flowers, ripe fruits, senescent or diseased organs from the plant. In tomato, pedicel abscission is an important agronomic factor that controls yield and post-harvest fruit quality. Two non-allelic mutations, jointless (j) and jointless-2 (j-2), controlling pedicel abscission zone formation have been documented but only j-2 has been extensively used in breeding. J was shown to encode a MADS-box protein. Using a combination of physical mapping and gene expression analysis we identified a positional candidate, Solyc12g038510, associated with j-2 phenotype. Targeted knockout of Solyc12g038510, using CRISPR/Cas9 system, validated our hypothesis. Solyc12g038510 encodes the MADS-box protein SlMBP21. Molecular analysis of j-2 natural variation revealed two independent loss-of-function mutants. The first results of an insertion of a Rider retrotransposable element. The second results of a stop codon mutation that leads to a truncated protein form. To bring new insights into the role of J and J-2 in abscission zone formation, we phenotyped the single and the double mutants and the engineered alleles. We showed that J is epistatic to J-2 and that the branched inflorescences and the leafy sepals observed in accessions harboring j-2 alleles are likely the consequences of linkage drags. [less ▲]

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See detailThe influence of health concerns in scientific and policy debates on climate change
Schütte, Stefanie; Depoux, Anneliese; Vigil Diaz Telenti, Sara ULg et al

in Journal of Epidemiology & Community Health (2017)

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See detailSpaces of in-between-ness and unbelonging: The hotel in short stories by Sefi Atta and Chimamanda Ngozi Adichie
Toivanen, Anna-Leena ULg

in English Studies in Africa (2017), 60(1), 1-11

Spaces of in-between-ness and unbelonging: The hotel in short stories by Se fi Atta and Chimamanda Ngozi Adichie Anna-Leena Toivanen The fi gure of the migrant has become a paradigmatic representative of ... [more ▼]

Spaces of in-between-ness and unbelonging: The hotel in short stories by Se fi Atta and Chimamanda Ngozi Adichie Anna-Leena Toivanen The fi gure of the migrant has become a paradigmatic representative of globalised postcoloniality. Yet, not all ‘ postcolonial ’ mobilities can be equated with migration. Cases in point are the travelling African protagonists of two diasporic Nigerian short stories, Se fi Atta ’ s ‘ Housekeeping ’ (2010) and Chimamanda Ngozi Adichie ’ s ‘ Transition to Glory ’ (2006). The short stories feature the fi gures of the African leisure traveller, tourist, and, in particular, hotel guest. The hotel articulates different dimensions of a site that is frequently conceived, both in fi ction and in theory, as a place and symbol of in-between- ness, deviance and displacement. In ‘ Housekeeping ’ , the hotel serves as a setting for exploring the socio-economic differences between migrant travellers and symbolises a sense of diasporic unbelonging. In ‘ Transition to Glory ’ ,the hotel room is used as a setting and symbol for an adulterous relationship. It comes across as a space of deviance which is not properly inscribed either in the private/domestic or the public. While set in spaces of in-between-ness and transit, both texts articulate metaphorical senses of longing for home. By analysing the literary representation of the hotel trope, this article contributes to widening the scope of how postcolonial mobilities can be understood. [less ▲]

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See detailDecreasing cloud cover drives the recent mass loss on the Greenland Ice Sheet
Hofer, S.; Tedstone, A.; Fettweis, Xavier ULg et al

in Science (2017), 3(6),

The Greenland Ice Sheet (GrIS) has been losing mass at an accelerating rate since the mid-1990s. This has been due to both increased ice discharge into the ocean and melting at the surface, with the ... [more ▼]

The Greenland Ice Sheet (GrIS) has been losing mass at an accelerating rate since the mid-1990s. This has been due to both increased ice discharge into the ocean and melting at the surface, with the latter being the dominant contribution. This change in state has been attributed to rising temperatures and a decrease in surface albedo. We show, using satellite data and climate model output, that the abrupt reduction in surface mass balance since about 1995 can be attributed largely to a coincident trend of decreasing summer cloud cover enhancing the melt-albedo feedback. Satellite observations show that, from 1995 to 2009, summer cloud cover decreased by 0.9 ± 0.3% per year. Model output indicates that the GrIS summer melt increases by 27 ± 13 gigatons (Gt) per percent reduction in summer cloud cover, principally because of the impact of increased shortwave radiation over the low albedo ablation zone. The observed reduction in cloud cover is strongly correlated with a state shift in the North Atlantic Oscillation promoting anticyclonic conditions in summer and suggests that the enhanced surface mass loss from the GrIS is driven by synoptic-scale changes in Arctic-wide atmospheric circulation. [less ▲]

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See detailCharacterizing the leaching of sperrylite (PtAs2) in cyanide-based solutions
Mwase Malumbo, James ULg; Petersen, Jochen

in Hydrometallurgy (2017)

The mineral sperrylite (PtAs2), unlike other Pt minerals, has shown to be resistant to cyanide leaching, even at elevated temperatures of 50 °C. This has prevented further development of a two-stage heap ... [more ▼]

The mineral sperrylite (PtAs2), unlike other Pt minerals, has shown to be resistant to cyanide leaching, even at elevated temperatures of 50 °C. This has prevented further development of a two-stage heap leaching process, of which the second stage is cyanide leaching for a Platreef ore, due to a considerable portion of the Pt being present as sperrylite. Through a comprehensive set of leaching tests, this study has shown that sperrylite leaches slowly in cyanide due to eventual passivation. The addition of ferricyanide to the cyanide solution results in significantly more Pt being leached (up to 16 times) than with cyanide only under identical process conditions. However, over time passivation occurred in this system also, but can be seemingly be overcome by filtering, rinsing and re-suspending the sperrylite. This was further investigated using a reactor system continuously fed with a ferricyanide-cyanide to leach a fixed bed of sperrylite mineral. Again, gradual passivation of the mineral phase was observed, which was fully reversible following a day of feeding with distilled water. XPS analysis of fresh and leached mineral indicated a depletion of As on the mineral surface, which tallied with an observed preferential leaching of As during leaching, at least initially. As a result, it is postulated that a less cyanide-soluble compound of the form PtAs(X) forms, where x is < 2. The ease with which the leaching process can be restarted after rinsing the mineral indicates that the adsorption of solution species is the key step in forming a passivating layer. This adsorption is potentially favoured by the gradual surface transformation. Finally, an electrochemical study confirmed that the ferricyanide-cyanide system facilitated an electron transfer reaction at the sperrylite surface with the likely oxidation of As and reduction of the ferricyanide. Gradual passivation of the surface was also observed in this system. [less ▲]

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See detailEvidence of activation of vagal afferents by non-invasive vagus nerve stimulation: An electrophysiological study in healthy volunteers
NONIS, Romain ULg; D'Ostilio, Kevin; SCHOENEN, Jean ULg et al

in Cephalalgia : An International Journal of Headache (2017)

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See detailUntangling glycaemia and mortality in critical care
Uyttendaele, Vincent ULg; Dickson, Jennifer L.; Shaw, Geoffrey M. et al

in Critical Care (2017), 21(1), 152

Background: Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often ... [more ▼]

Background: Hyperglycaemia is associated with adverse outcomes in the intensive care unit, and initial studies suggested outcome benefits of glycaemic control (GC). However, subsequent studies often failed to replicate these results, and they were often unable to achieve consistent, safe control, raising questions about the benefit or harm of GC as well as the nature of the association of glycaemia with mortality and clinical outcomes. In this study, we evaluated if non-survivors are harder to control than survivors and determined if glycaemic outcome is a function of patient condition and eventual outcome or of the glycaemic control provided. Methods: Clinically validated, model-based, hour-to-hour insulin sensitivity (SI) and its hour-to-hour variability (%ΔSI) were identified over the first 72 h of therapy in 145 patients (119 survivors, 26 non-survivors). In hypothesis testing, we compared distributions of SI and %ΔSI in 6-hourly blocks for survivors and non-survivors. In equivalence testing, we assessed if differences in these distributions, based on blood glucose measurement error, were clinically significant. Results: SI level was never equivalent between survivors and non-survivors (95% CI of percentage difference in medians outside ±12%). Non-survivors had higher SI, ranging from 9% to 47% higher overall in 6-h blocks, and this difference became statistically significant as glycaemic control progressed. %ΔSI was equivalent between survivors and non-survivors for all 6-hourly blocks (95% CI of difference in medians within ±12%) and decreased in general over time as glycaemic control progressed. Conclusions: Whereas non-survivors had higher SI levels, variability was equivalent to that of survivors over the first 72 h. These results indicate survivors and non-survivors are equally controllable, given an effective glycaemic control protocol, suggesting that glycaemia level and variability, and thus the association between glycaemia and outcome, are essentially determined by the control provided rather than by underlying patient or metabolic condition. [less ▲]

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See detailOne-step hydrothermal synthesis and electrochemical performance of sodium-manganese-iron phosphate as cathode material for Li-ion batteries
Karegeya, Claude ULg; Mahmoud, Abdelfattah ULg; Vertruyen, Bénédicte ULg et al

in Journal of Solid State Chemistry (2017), 253

The sodium-manganese-iron phosphate Na2Mn1.5Fe1.5(PO4)3 (NMFP) with alluaudite structure was obtained by a one-step hydrothermal synthesis route. The physical properties and structure of this material ... [more ▼]

The sodium-manganese-iron phosphate Na2Mn1.5Fe1.5(PO4)3 (NMFP) with alluaudite structure was obtained by a one-step hydrothermal synthesis route. The physical properties and structure of this material were obtained through XRD and Mössbauer analyses. X-ray diffraction Rietveld refinements confirm a cationic distribution of Na+ and presence of vacancies in A(2)’, Na+ and small amounts of Mn2+ in A(1), Mn2+ in M(1) , 0.5 Mn2+ and Fe cations (Mn2+,Fe2+ and Fe3+) in M(2), leading to the structural formula Na2Mn(Mn0.5Fe1.5)(PO4)3. The particles morphology was investigated by SEM. Several reactions with different hydrothermal reaction times were attempted to design a suitable synthesis protocol of NMFP compound. The time of reaction was varied from 6 to 48 hours at 220°C. The pure phase of NMFP particles was firstly obtained when the hydrothermal reaction of NMFP precursors mixture was maintained at 220°C for 6 hours. When the reaction time was increased from 6 to 12, 24 and 48 hours, the dandelion structure was destroyed in favor of NMFP micro-rods. The combination of NMFP (NMFP-6H, NMFP-12H, NMFP-24H and NMFP-48H) structure refinement and Mössbauer characterizations shows that the increase of the reaction time leads to the progressive increment of Fe(III) and the decrease of the crystal size. The electrochemical tests indicated that NMFP is a 3 V sodium intercalating cathode. The comparison of the discharge capacity evolution of studied NMFP electrode materials at C/5 current density shows different capacities of 48, 40, 34 and 34 mAhg-1 for NMFP-6H, NMFP-12H, NMFP-24H and NMFP-48H respectively. Interestingly, all samples show excellent capacity retention of about 99 % during 50 cycles. [less ▲]

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See detailMorphology Development and Mechanical Properties Variation during Cold-Drawing of Polyethylene-Clay Nanocomposite Fibers
Coppola, Bartolomeo ULg; Scarfato, Paola; Incarnato, Loredana et al

in Polymers (2017), 9(6), 235-251

In this work, the influence of composition and cold-drawing on nano- and micro-scale morphology and tensile mechanical properties of PE/organoclay nanocomposite fibers was investigated. Nanocomposites ... [more ▼]

In this work, the influence of composition and cold-drawing on nano- and micro-scale morphology and tensile mechanical properties of PE/organoclay nanocomposite fibers was investigated. Nanocomposites were prepared by melt compounding in a twin-screw extruder, using a maleic anhydride grafted linear low density polyethylene (LLDPE–g–MA) and an organomodified montmorillonite (Dellite 67G) at three different loadings (3, 5 and 10 wt %). Fibers were produced by a single-screw extruder and drawn at five draw ratios (DRs): 7.25, 10, 13.5, 16 and 19. All nanocomposites, characterized by XRD, SEM, TEM, and FT-IR techniques, showed an intercalated/exfoliated morphology. The study evidenced that the nanoclay presence significantly increases both elastic modulus (up to +115% for fibers containing 10 wt % of D67G) and drawability of as-spun nanocomposite fibers. Moreover, at fixed nanocomposite composition, the cold-drawing process increases fibers elastic modulus and tensile strength at increasing DRs. However, at high DRs, “face-to-edge” rearrangement phenomena of clay layers (i.e., clay layers tend to rotate and touch each other) arise in fibers at high nanoclay loadings. Finally, nanocomposite fibers show a lower diameter reduction during drawing, with respect to the plain system, and surface feature of adjustable roughness by controlling the composition and the drawing conditions. [less ▲]

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See detailDesign and experimental validation of an adaptive control law to maximize power generation of a small-scale waste heat recovery system
Hernandez Naranjo, Jairo Andrés ULg; Desideri, Adriano ULg; Gusev, Sergei et al

in Applied Energy (2017), 203

Increasing the energy efficiency of industrial processes is a challenge that involves, not only improving the methodologies for design and manufacturing, but optimizing performance during part-load ... [more ▼]

Increasing the energy efficiency of industrial processes is a challenge that involves, not only improving the methodologies for design and manufacturing, but optimizing performance during part-load operation and transient conditions. A well-adopted solution consists of developing waste heat recovery (WHR) systems based on Organic Rankine Cycle (ORC) power units. The highest efficiency for such cycle is obtained at low superheating values, corresponding to the situation where the system exhibits time-varying nonlinear dynamics, triggered by the fluctuating nature of the waste heat source. In this paper, an adaptive control law using the Model Predictive Control (MPC) framework is proposed. This work goes a step beyond most of the existing scientific works in the field of ORC power systems, since the MPC controller is implemented in a lab-scale prototype, and its performance compared against a gain-scheduled PID strategy. The experimental results show that the adaptive MPC outperforms the gain-scheduled PID based strategy, as it allows to accurately regulate the evaporating temperature, while keeping vapor condition at the inlet of the expander i.e., the superheating, in a safe operating range, thus increasing the net power generation. [less ▲]

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See detailContributions of U-Th-Pb dating on the diagenesis and sediment sources of the Lower Group (BI) of the Mbuji-Mayi Supergroup (Democratic Republic of Congo)
François, Camille ULg; Kabamba Baludikay, Blaise ULg; Storme et al

in Precambrian Research (2017)

In this paper, we present new age constraints for the lower part of the Meso-Neoproterozoic sedimentary Mbuji-Mayi Supergroup (Democratic Republic of Congo, DRC). This Supergroup preserves a large ... [more ▼]

In this paper, we present new age constraints for the lower part of the Meso-Neoproterozoic sedimentary Mbuji-Mayi Supergroup (Democratic Republic of Congo, DRC). This Supergroup preserves a large diversity of organic-walled microfossils, evidencing the diversification of early eukaryotes for the first time in Central Africa. We use different methods such as in situ U-Pb geochronology by LA-ICP-MS and U-Th-Pb chemical datings by Electron Microprobe on diagenetic and detrital minerals such as xenotimes, monazites and zircons. We attempt to better constrain the provenance of the Mbuji-Mayi sediments and the minimum age of the Mbuji-Mayi Supergroup to constrain the age of the microfossils. Results with LA-ICP-MS and EMP provide new ages between 1030 and 1065 Ma for the diagenesis of the lower part of the sedimentary sequence. These results are consistent with data on biostratigraphy supporting the occurrence of worldwide changes at the Mesoproterozoic/Neoproterozoic boundary. [less ▲]

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See detailDevelopment of an open-source algorithm based on inertial measurement units (IMU) of a smartphone to detect cattle grass intake and ruminating behaviors
Andriamandroso, Andriamasinoro ULg; Lebeau, Frédéric ULg; Beckers, Yves ULg et al

in Computers & Electronics in Agriculture (2017), 139

In this paper, an open algorithm was developed for the detection of cattle’s grass intake and rumination activities. This was done using the widely available inertial measurement unit (IMU) from a ... [more ▼]

In this paper, an open algorithm was developed for the detection of cattle’s grass intake and rumination activities. This was done using the widely available inertial measurement unit (IMU) from a smartphone, which contains an accelerometer, a gyroscope, a magnetometer and location sensors signals sampled at 100 Hz. This equipment was mounted on 19 grazing cows of different breeds and daily video sequences were recorded on pasture of different forage allowances. After visually analyzing the cows’ movements on a calibration database, signal combinations were selected and thresholds were determined based on 1-s time windows, since increasing the time window did not increase the accuracy of detection. The final algorithm uses the average value and standard deviation of two signals in a two-step discrimination tree: the gravitational acceleration on x-axis (Gx) expressing the cows’ head movements and the rotation rate on the same x-axis (Rx) expressing jaw movements. Threshold values encompassing 95% of the normalized calibrated data gave the best results. Validation on an independent database resulted in an average detection accuracy of 92% with a better detection for rumination (95%) than for grass intake (91%). The detection algorithm also allows for characterization of the diurnal feeding activities of cattle at pasture. Any user can make further improvements, for data collected at the same way as the iPhone’s IMU has done, since the algorithm codes are open and provided as supplementary data. [less ▲]

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See detailFrustrated crystallization of a monolayer of magnetized beads under geometrical confinement
Schockmel, Julien ULg; Vandewalle, Nicolas ULg; Opsomer, Eric ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2017)

We present a systematic experimental study of the confinement effect on the crystallization of a monolayer of magnetized beads. The particles are millimeter-scale grains interacting through the short ... [more ▼]

We present a systematic experimental study of the confinement effect on the crystallization of a monolayer of magnetized beads. The particles are millimeter-scale grains interacting through the short range magnetic dipole-dipole potential induced by an external magnetic field. The grains are confined by repulsing walls and are homogeneously distributed inside the cell. A two-dimensional (2d) Brownian motion is induced by horizontal mechanical vibrations. Therefore, the balance between magnetic interaction and agitation allows investigating 2d phases through direct visualization. The effect of both confinement size and shape on the grains’ organization in the low-energy state has been investigated. Concerning the confinement shape, triangular, square, pentagonal, hexagonal, heptagonal, and circular geometries have been considered. The grain organization was analyzed after a slow cooling process. Through the measurement of the averaged bond order parameter for the different confinement geometries, it has been shown that cell geometry strongly affects the ordering of the system. Moreover, many kinds of defects, whose observation rate is linked to the geometry, have been observed: disclinations, dislocations, defects chain, and also more exotic defects such as a rosette. Finally, the influence of confinement size has been investigated and we point out that no finite-size effect occurs for a hexagonal cell, but the finite-size effect changes from one geometry to another. [less ▲]

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See detailComparison of UAS photogrammetric products for tree detection and characterization of coniferous stands
Bonnet, Stéphanie ULg; Lisein, Jonathan ULg; Lejeune, Philippe ULg

in International Journal of Remote Sensing (2017), 38(19), 5310-5337

The use of Unmanned Aerial Systems (UAS) opens a new era for remote sensing and forest management, which requires accurate and regular quantification of resources. In this study, we propose a ... [more ▼]

The use of Unmanned Aerial Systems (UAS) opens a new era for remote sensing and forest management, which requires accurate and regular quantification of resources. In this study, we propose a comprehensive workflow to detect trees and assess forest attributes in the particular context of coniferous stands in transformation from even-aged to uneven-aged stands, using UAS imagery, from data acquisition to model construction. We implement a local maxima detection to identify the tree tops, based on a fixed-radius moving window in a Canopy Height Model (CHM) and images produced from UAS surveys. To compare the contribution of different photogrammetric products, we analysed the local maxima detected from the CHM, from three image types (individual rectified and ortho-rectified images and ortho-mosaic) and from a combination of both CHM and images. The local maxima detection gave promising results, with low omission and true-positive rates of up to 89.2%. A filtering process of false positives was implemented, using a supervised classification which decreased the false positives up to 2.6%. Based on the local maxima combined with an area-based approach, we constructed models to assess top height (R2: 83%, root mean square error [RMSE]: 5.7%), number of stems (R2: 71%, RMSE: 28.3%), basal area (R2: 70%, RMSE: 16.2%), volume (R2: 69%, RMSE: 20.1%), and individual tree height (R2: 70%, RMSE: 7.2%). Despite a suboptimal data acquisition, our simple and flexible method has yielded good results and shows great potential for application. [less ▲]

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See detailBody shape convergence driven by small size optimum in marine angelfishes
Frederich, Bruno ULg; Santini, Francesco; Konow, Nicolai et al

in Biology Letters (2017), 13

Convergent evolution of small body size occurs across many vertebrate clades and may reflect an evolutionary response to shared selective press- ures. However it remains unclear if other aspects of ... [more ▼]

Convergent evolution of small body size occurs across many vertebrate clades and may reflect an evolutionary response to shared selective press- ures. However it remains unclear if other aspects of phenotype undergo convergent evolution in miniaturized lineages. Here we present a comparative analysis of body size and shape evolution in marine angelfishes (Pomacanthidae), a reef fish family characterized by repeated transitions to small body size. We ask if lineages that evolve small sizes show convergent evolution in body shape. Our results reveal that angelfish lineages evolved three different stable size optima with one corresponding to the group of pygmy angelfishes (Centropyge). Then, we test if the observed shifts in body size are associated with changes to new adaptive peaks in shape. Our data suggest that independent evolution to small size optima have induced repeated convergence upon deeper body and steeper head profile in Centropyge. These traits may favour manoeuvrability and visual aware- ness in these cryptic species living among corals, illustrating that functional demands on small size may be related to habitat specialization and predator avoidance. The absence of shape convergence in large marine angelfishes also suggests that more severe requirements exist for small than for large size optima. [less ▲]

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See detailLuteinizing Hormone Deficiency: Historical Views and Perspectives
VALDES SOCIN, Hernan Gonzalo ULg; Daly, Adrian ULg; BECKERS, Albert ULg

in Austin Andrology (2017), 2(1), 1-2

Fertility in men requires normal testicular development, which is controlled by chorionic gonadotropin (hCG) in utero and thereafter by luteinizing hormone (LH) and follicle-stimulating hormone (FSH ... [more ▼]

Fertility in men requires normal testicular development, which is controlled by chorionic gonadotropin (hCG) in utero and thereafter by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Some rare observations, such as, mutations in the luteinizing hormone subunit beta gene [2] have contributed substantially to our understanding of reproductive development and male infertility. In this editorial we summaryze current knowledge about beta LH mutations and polymorphism in men and discuss fertility issues. [less ▲]

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See detailMethodological approach for the implementation of a simulator in augmented reality in a radiation therapy department
Servotte, Jean-Christophe ULg; Guillaume, Michèle ULg; BOGA, Deniz ULg et al

in International Journal of Healthcare Management (2017), 10(3), 154-159

Radiation therapy (RT) is one of the cornerstones for the treatment of cancer. In most countries RT machines are handled by professionals benefitting from an ad hoc training in theoretical knowledge as ... [more ▼]

Radiation therapy (RT) is one of the cornerstones for the treatment of cancer. In most countries RT machines are handled by professionals benefitting from an ad hoc training in theoretical knowledge as well as technical and non-technical skills. In Belgium, RT departments are hiring in nurses for this activity. In countries where there is a specified core curriculum for basic training of radiation technologist, this basic training falls short once in practice and there is an obvious requirement for a continuous updating of skills in order to keep up with the accelerating evolution of technology. Therefore, the decision has been taken to implement a simulator in augmented reality in the RT department in Liège, to face the double challenge i.e. basic professional training as well as continuous education in technical and nontechnical skills and Crew Resource Management. We describe a methodological approach to implement this simulator in augmented reality. [less ▲]

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See detailEMT and inflammation: inseparable actors of cancer progression.
Suarez-Carmona, Meggy; Lesage, Julien; Cataldo, Didier ULg et al

in Molecular Oncology (2017)

Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters ... [more ▼]

Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tumor establish a cross-talk with tumor cells that may result in a phenotype switch into tumor-supporting cells. This has been particularly well described for macrophages and is referred to as tumor-associated "M2" polarization. Epithelial-to-mesenchymal transition (EMT), the embryonic program that loosens cell-cell adherence complexes and endows cells with enhanced migratory and invasive properties, can be co-opted by cancer cells during metastatic progression. Cancer cells that have undergone EMT are more aggressive, displaying increased invasiveness, stem-like features and resistance to apoptosis. EMT programs can also stimulate the production of pro-inflammatory factors by cancer cells. Conversely, inflammation is a potent inducer of EMT in tumors. Therefore, the two phenomena may sustain each other, in an alliance for metastasis. This is the focus of this review, where the interconnections between EMT programs and cellular and molecular actors of inflammation are described. We also recapitulate data linking the EMT/inflammation axis to metastasis. [less ▲]

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See detailLe principe non bis in idem et les procédures mixtes : un camouflet infligé à la jurisprudence Zalotoukhine ?
Michiels, Olivier ULg; Falque, Géraldine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (2017/23), 1069-1078

Pour lutter contre certains comportements socialement inacceptables, les États peuvent concevoir des réponses juridiques complémentaires au moyen de procédures mixtes pour autant que celles-ci forment un ... [more ▼]

Pour lutter contre certains comportements socialement inacceptables, les États peuvent concevoir des réponses juridiques complémentaires au moyen de procédures mixtes pour autant que celles-ci forment un tout cohérent, c’est-à-dire qu’elles soient liées par un lien matériel et temporel suffisamment étroit. Le cumul des sanctions pénales et administratives est autorisé dès lors que les deux procédures poursuivent des buts complémentaires et traitent d’aspects différents de l’acte préjudiciable, que le cumul des sanctions soit prévisible, qu’il n’y ait pas de répétition dans la collecte et dans l’appréciation des preuves et qu’un mécanisme de compensation entre les sanctions soit prévu. [less ▲]

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See detailSbCOMT (Bmr12) is involved in the biosynthesis of tricin-lignin in sorghum
Eudes, Aymerick; Dutta, Tanmoy; Deng, Kei et al

in PLoS ONE (2017), 12(6), 1-11

Lignin in plant biomass represents a target for engineering strategies towards the development of a sustainable bioeconomy. In addition to the conventional lignin monomers, namely p-coumaryl, coniferyl ... [more ▼]

Lignin in plant biomass represents a target for engineering strategies towards the development of a sustainable bioeconomy. In addition to the conventional lignin monomers, namely p-coumaryl, coniferyl and sinapyl alcohols, tricin has been shown to be part of the native lignin polymer in certain monocot species. Because tricin is considered to initiate the polymerization of lignin chains, elucidating its biosynthesis and mechanism of export to the cell wall constitute novel challenges for the engineering of bioenergy crops. Late steps of tricin biosynthesis require two methylation reactions involving the pathway intermediate selgin. It has recently been demonstrated in rice and maize that caffeate O-methyltransferase (COMT) involved in the synthesis syringyl (S) lignin units derived from sinapyl alcohol also participates in the synthesis of tricin in planta. In this work, we validate in sorghum (Sorghum bicolor L.) that the O-methyltransferase responsible for the production of S lignin units (SbCOMT / Bmr12) is also involved in the synthesis of lignin-linked tricin. In particular, we show that biomass from the sorghum bmr12 mutant contains lower level of tricin incorporated into lignin, and that SbCOMT can methylate the tricin precursors luteolin and selgin. Our genetic and biochemical data point toward a general mechanism whereby COMT is involved in the synthesis of both tricin and S lignin units. [less ▲]

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See detailDiscovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines
Schnekenburger, M; Goffin, Eric ULg; Lee, J-Y et al

in Journal of Medicinal Chemistry (2017), 60(11), 4714-4733

A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting ... [more ▼]

A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. On the basis of computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea] which displays a potent antiproliferative activity on various glioma cell types, assessed by quantitative videomicroscopy, eventually triggering senescence. The impact on normal glial cells was lower with a selectivity index of >10. Furthermore, human U373 and Hs683 glioblastoma cell lines served to demonstrate the inhibitory activity of 18 against histone deacetylase (HDAC) class III sirtuins 1 and 2 (SIRT1/2) by quantifying acetylation levels of histone and non-histone proteins. The translational potential of 18 was validated by an NCI-60 cell line screen and validation of growth inhibition of drug resistant cancer cell models. Eventually, the anticancer potential of 18 was validated in 3D glioblastoma spheroids and in vivo by zebrafish xenografts. In summary, compound 18 is the first representative of a new class of SIRT inhibitors opening new perspectives in the medicinal chemistry of HDAC inhibitors. [less ▲]

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See detailMolecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo
Mvumbi Makaba, Dieudonné; Bobanga Lengu, Thierry; Kayembe Ntumba, Jean-Marie et al

in PLoS ONE (2017)

Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the ... [more ▼]

Malaria is a major public health problem in the Democratic Republic of Congo. Despite progress achieved over the past decade in the fight against malaria, further efforts have to be done such as in the surveillance and the containment of Plasmodium falciparum resistant strains. We investigated resistance to artemisinin-based combination therapies currently in use in Democratic Republic of Congo by surveying molecular polymorphisms in three genes: pfcrt, pfmdr1 and pfk13 to explore possible emergence of amodiaquine, lumefantrine or artemisinin resistance in Democratic Republic of Congo. This study essentially revealed that resistance to chloroquine is still decreasing while polymorphism related to amodiaquine resistance seems to be not present in Democratic Republic of Congo, that three samples, located in the east of the country, harbor Pfmdr1 amplification and that none of the mutations found in South-East Asia correlated with artemisinine resistance have been found in Democratic Republic of Congo. But new mutations have been identified, especially the M476K, occurred in the same position that the M476I previously identified in the F32-ART strain, strongly resistant to artemisinine. Antimalarial first-line treatments currently in use in Democratic Republic of Congo are not associated with emergence of molecular markers of resistance. [less ▲]

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See detailDiversity of farming systems integrating fish pond aquaculture in the province of Kinshasa in the Democratic Republic of the Congo
Mafwila Kinkela, Patrick ULg; Kambashi Mutiaka, Bienvenu ULg; Dogot, Thomas ULg et al

in Journal of Agriculture and Rural Development in the Tropics and Subtropics (2017), Vol 118(No 1), 149-160

Agriculture and aquaculture systems are used by many farmers in various tropical countries of Asia, America and Africa. They have proven their relevancy to increase the productivity of farms by optimising ... [more ▼]

Agriculture and aquaculture systems are used by many farmers in various tropical countries of Asia, America and Africa. They have proven their relevancy to increase the productivity of farms by optimising nutrient fluxes and reducing requirements for external fertilisers. This article analysed the current state of fish farming and the way it is integrated with other farm subsystems in the urban/peri-urban and rural areas of Kinshasa, Democratic Republic of Congo. More precisely, it examined the allocation of resources at the farm level, the recovery of helophytes plants, and the fate of fish production choices and it explored the possibility of intensifying these existing integrated farming systems. After a census of ponds in the urban and rural areas of Kinshasa, an on-site survey was conducted on 150 fish pond farms to assess the different activities practiced on farms, the impact of integrating crops and livestock to fish pond aquaculture and the constraints of the system. A total of three thousand and twenty (3020) fish ponds were recorded in the urban and rural areas of Kinshasa. Among these farms integrated aquaculture-agriculture systems exist with a wide diversity of practices (about 79% of farms combined fish with livestock and/or vegetable production). No striking differences between fish farms according to the allocation of resources, fish production method such as monoculture or polyculture, the recovery of helophytes plants and the fate of fish production choice were found depending on the location. However, fish farms were differently managed when combined with agriculture and/or livestock. Regarding the integration of the different subsystems through nutrient fluxes, 11 different movements of material between subsystems were found in integrated farms. However, not all fluxes are equally used in all farms and therefore improvements cannot be generalised. Improvements to be explored are such as making better use of manure pond mud and helophyte plants. For this purpose, proper training of farmers might be critical. Finally, bringing farmers together in cooperatives could also contribute to reduce the cost of purchase and transportation of fish fry and feed. [less ▲]

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See detailWhole blood microsampling for the quantitation of estetrol without derivatization by liquid chromatography-tandem mass spectrometry
Nys, Gwenaël ULg; Gallez, Anne ULg; Kok, Miranda ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2017), 140

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See detailL’article 458 du Code des impôts sur les revenus est-il un frein à l’intervention du fisc en procédure pénale ?
Michiels, Olivier ULg

in Journal des Tribunaux (2017), 2017/21(n° 6691), 398-400

L'article aborde la question de la constitution de partie civile de l'Etat, administration des contributions directes, en cas de fraude fiscale. Il envisage notamment ce sujet au regard de l'article 458 ... [more ▼]

L'article aborde la question de la constitution de partie civile de l'Etat, administration des contributions directes, en cas de fraude fiscale. Il envisage notamment ce sujet au regard de l'article 458 du CIR qui prévoit que les personnes qui auront été condamnées comme auteurs ou complices d’infractions visées aux articles 449 à 452 du Code des impôts sur les revenus seront tenues solidairement au paiement de l’impôt éludé. [less ▲]

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See detailActivation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment
Dupuis, Nadine ULg; Laschet, Céline ULg; Franssen, Delphine ULg et al

in Molecular Pharmacology (2017), 91(6), 595-608

G protein-coupled receptors are the most important drug targets for human diseases. An important number of them remain devoid of confirmed ligands. GPR27 is one of these orphan receptors, characterized by ... [more ▼]

G protein-coupled receptors are the most important drug targets for human diseases. An important number of them remain devoid of confirmed ligands. GPR27 is one of these orphan receptors, characterized by a high level of conservation among vertebrates and a predominant expression in the central nervous system. In addition, it has recently been linked to insulin secretion. However, the absence of endogenous or surrogate ligands for GPR27 complicates the examination of its biological function. Our aim was to validate GPR27 signaling pathways and therefore we sought to screen a diversity oriented synthesis library to identify GPR27-specific surrogate agonists. In order to select an optimal screening assay, we investigated GPR27 ligand-independent activity. Both in G protein-mediated pathways and in β-arrestin 2 recruitment, no ligand-independent activity could be measured. However, we observed a recruitment of β-arrestin 2 to a GPR27V2 chimera in the presence of membrane-anchored β-adrenergic receptor kinase 1 (GRK2). Therefore, we optimized a firefly luciferase complementation assay to screen against this chimeric receptor. We identified two compounds (N-[4-(anilinocarbonyl)phenyl]-2,4-dichlorobenzamide (ChemBridge ID5128535) and 2,4-dichloro-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}benzamide (ChemBridge ID5217941)) sharing a N-phenyl-2,4-dichlorobenzamide scaffold, which were selective for GPR27 over its closely related family members GPR85 and GPR173. The specificity of the activity was confirmed with a NanoBiT® β-arrestin 2 assay, imaging of GFP-tagged β-arrestin 2 and PathHunter® β-arrestin 2 Assay. Interestingly, no G protein activation was detected upon activation of GPR27 by these compounds. Our study provides the first selective surrogate agonists for the orphan GPR27. [less ▲]

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See detailH0LiCOW - III. Quantifying the effect of mass along the line of sight to the gravitational lens HE 0435-1223 through weighted galaxy counts★
Rusu, Cristian E.; Fassnacht, Christopher D.; Sluse, Dominique ULg et al

in Monthly Notices of the Royal Astronomical Society (2017), 467

Based on spectroscopy and multiband wide-field observations of the gravitationally lensed quasar HE 0435-1223, we determine the probability distribution function of the external convergence κ[SUB]ext[/SUB ... [more ▼]

Based on spectroscopy and multiband wide-field observations of the gravitationally lensed quasar HE 0435-1223, we determine the probability distribution function of the external convergence κ[SUB]ext[/SUB] for this system. We measure the under/overdensity of the line of sight towards the lens system and compare it to the average line of sight throughout the Universe, determined by using the CFHTLenS (The Canada France Hawaii Lensing Survey) as a control field. Aiming to constrain κ[SUB]ext[/SUB] as tightly as possible, we determine under/overdensities using various combinations of relevant informative weighting schemes for the galaxy counts, such as projected distance to the lens, redshift and stellar mass. We then convert the measured under/overdensities into a κ[SUB]ext[/SUB] distribution, using ray-tracing through the Millennium Simulation. We explore several limiting magnitudes and apertures, and account for systematic and statistical uncertainties relevant to the quality of the observational data, which we further test through simulations. Our most robust estimate of κ[SUB]ext[/SUB] has a median value κ^med_ext = 0.004 and a standard deviation σ[SUB]κ[/SUB] = 0.025. The measured σ[SUB]κ[/SUB] corresponds to 2.5 per cent relative uncertainty on the time delay distance, and hence the Hubble constant H[SUB]0[/SUB] inferred from this system. The median κ^med_ext value varies by ˜0.005 with the adopted aperture radius, limiting magnitude and weighting scheme, as long as the latter incorporates galaxy number counts, the projected distance to the main lens and a prior on the external shear obtained from mass modelling. This corresponds to just ˜0.5 per cent systematic impact on H[SUB]0[/SUB]. The availability of a well-constrained κ[SUB]ext[/SUB] makes HE 0435-1223 a valuable system for measuring cosmological parameters using strong gravitational lens time delays. [less ▲]

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See detailValidation of MOPITT carbon monoxide using ground-based Fourier transform infrared spectrometer data from NDACC
Buchholz, R. R.; Deeter, M. N.; Worden, H. M. et al

in Atmospheric Measurement Techniques (2017), 10(5), 1927--1956

The Measurements of Pollution in the Troposphere (MOPITT) satellite instrument provides the longest continuous dataset of carbon monoxide (CO) from space. We perform the first validation of MOPITT version ... [more ▼]

The Measurements of Pollution in the Troposphere (MOPITT) satellite instrument provides the longest continuous dataset of carbon monoxide (CO) from space. We perform the first validation of MOPITT version 6 retrievals using total column CO measurements from ground-based remote-sensing Fourier transform infrared spectrometers (FTSs). Validation uses data recorded at 14 stations, that span a wide range of latitudes (80°N to 78°S), in the Network for the Detection of Atmospheric Composition Change (NDACC). MOPITT measurements are spatially co-located with each station, and different vertical sensitivities between instruments are accounted for by using MOPITT averaging kernels (AKs). All three MOPITT retrieval types are analyzed: thermal infrared (TIR-only), joint thermal and near infrared (TIR–NIR), and near infrared (NIR-only). Generally, MOPITT measurements overestimate CO relative to FTS measurements, but the bias is typically less than 10%. Mean bias is 2.4% for TIR-only, 5.1% for TIR–NIR, and 6.5% for NIR-only. The TIR–NIR and NIR-only products consistently produce a larger bias and lower correlation than the TIR-only. Validation performance of MOPITT for TIR-only and TIR–NIR retrievals over land or water scenes is equivalent. The four MOPITT detector element pixels are validated separately to account for their different uncertainty characteristics. Pixel 1 produces the highest standard deviation and lowest correlation for all three MOPITT products. However, for TIR-only and TIR–NIR, the error-weighted average that includes all four pixels often provides the best correlation, indicating compensating pixel biases and well-captured error characteristics. We find that MOPITT bias does not depend on latitude but rather is influenced by the proximity to rapidly changing atmospheric CO. MOPITT bias drift has been bound geographically to within ±0.5%/yr or lower at almost all locations. [less ▲]

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See detailThe VLT/NaCo large program to probe the occurrence of exoplanets and brown dwarfs at wide orbits. IV. Gravitational instability rarely forms wide, giant planets
Vigan, A.; Bonavita, M.; Biller, B. et al

in Astronomy and Astrophysics (2017), 603

Understanding the formation and evolution of giant planets (≥1 M[SUB]Jup[/SUB]) at wide orbital separation (≥5 AU) is one of the goals of direct imaging. Over the past 15 yr, many surveys have placed ... [more ▼]

Understanding the formation and evolution of giant planets (≥1 M[SUB]Jup[/SUB]) at wide orbital separation (≥5 AU) is one of the goals of direct imaging. Over the past 15 yr, many surveys have placed strong constraints on the occurrence rate of wide-orbit giants, mostly based on non-detections, but very few have tried to make a direct link with planet formation theories. In the present work, we combine the results of our previously published VLT/NaCo large program with the results of 12 past imaging surveys to constitute a statistical sample of 199 FGK stars within 100 pc, including three stars with sub-stellar companions. Using Monte Carlo simulations and assuming linear flat distributions for the mass and semi-major axis of planets, we estimate the sub-stellar companion frequency to be within 0.75-5.70% at the 68% confidence level (CL) within 20-300 AU and 0.5-75 M[SUB]Jup[/SUB], which is compatible with previously published results. We also compare our results with the predictions of state-of-the-art population synthesis models based on the gravitational instability (GI) formation scenario with and without scattering. We estimate that in both the scattered and non-scattered populations, we would be able to detect more than 30% of companions in the 1-75 M[SUB]Jup[/SUB] range (95% CL). With the threesub-stellar detections in our sample, we estimate the fraction of stars that host a planetary system formed by GI to be within 1.0-8.6% (95% CL). We also conclude that even though GI is not common, it predicts a mass distribution of wide-orbit massive companions that is much closer to what is observed than what the core accretion scenario predicts. Finally, we associate the present paper with the release of the Direct Imaging Virtual Archive (DIVA), a public database that aims at gathering the results of past, present, and future direct imaging surveys. Based on observations collected at the European Southern Observatory, Chile (ESO Large Program 184.C-0157 and Open Time 089.C-0137A and 090.C-0252A). [less ▲]

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See detailA seven-planet resonant chain in TRAPPIST-1
Luger, Rodrigo; Sestovic, Marko; Kruse, Ethan et al

in Nature Astronomy (2017), 1

The TRAPPIST-1 system is the first transiting planet system found orbiting an ultracool dwarf star[SUP] 1 [/SUP]. At least seven planets similar in radius to Earth were previously found to transit this ... [more ▼]

The TRAPPIST-1 system is the first transiting planet system found orbiting an ultracool dwarf star[SUP] 1 [/SUP]. At least seven planets similar in radius to Earth were previously found to transit this host star[SUP] 2 [/SUP]. Subsequently, TRAPPIST-1 was observed as part of the K2 mission and, with these new data, we report the measurement of an 18.77 day orbital period for the outermost transiting planet, TRAPPIST-1 h, which was previously unconstrained. This value matches our theoretical expectations based on Laplace relations[SUP] 3 [/SUP] and places TRAPPIST-1 h as the seventh member of a complex chain, with three-body resonances linking every member. We find that TRAPPIST-1 h has a radius of 0.752 R [SUB]⊕[/SUB] and an equilibrium temperature of 173 K. We have also measured the rotational period of the star to be 3.3 days and detected a number of flares consistent with a low-activity, middle-aged, late M dwarf. [less ▲]

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See detailWaste Heat Recovery by Means of Organic Rankine Cycle (ORC) System Coupled with Two-Phase Closed Thermosyphons
Le, Van Long ULg; Declaye, Sébastien ULg; Dumas, Xavier et al

in International Journal of Thermodynamics (2017)

This paper aims at assessing the performance of a waste heat-to-power plant by means of an ORC (Organic Rankine Cycle) system coupled with two-phase closed thermosyphons (or gravity-assisted heat pipes or ... [more ▼]

This paper aims at assessing the performance of a waste heat-to-power plant by means of an ORC (Organic Rankine Cycle) system coupled with two-phase closed thermosyphons (or gravity-assisted heat pipes or wickless heat pipes). The heat exchanger, made up of two-phase closed thermosyphons, is used for conveying heat from exhaust stream to ORC working fluid. In reality, a hot oil loop or a pressurized hot water loop or a saturated ste am loop or even a direct evaporator is often used to transfer heat from the heat source to the ORC system. However, installing a heat exchanger directly in the hot gas paths of ORC system evokes the concerns for the flammability and/or toxicity of organic working fluids especially when the heat source has a relatively high temperature. Also the use of an intermediate heat carrier loop such as thermal oil or saturated steam or pressurized water loop is costly and involves installation of comparatively heavy components. In principle, the use of two-phase closed thermosyphons for capturing and transporting heat from a waste heat source to organic working fluid is less expensive than utilizing an intermediate heat transfer loop and eliminates safety issues as in the case of direct installation of an ORC evaporator in the hot gas paths. [less ▲]

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See detailSurface Modification of Powder Metallurgy Titanium by Colloidal Techniques and Diffusion Processes for Biomedical Applications
Ureña, Julia; Mendoza Gallego, Carlos ULg; Ferrari, Begoña et al

in Advanced Engineering Materials (2017), 19(6),

This contribution focuses on modifying the composition and surface characteristics of powder metallurgy titanium substrates to improve their wear resistance and to reduce the surface Younǵs modulus, while ... [more ▼]

This contribution focuses on modifying the composition and surface characteristics of powder metallurgy titanium substrates to improve their wear resistance and to reduce the surface Younǵs modulus, while maintaining the corrosion resistance and biocompatibility. The modification consists of Mo and TiN coatings produced by colloidal techniques which are deposited by electrophoretic deposition (EPD) or spraying onto green or sintered titanium substrates. The final surface structures are formed during a heat treatment, during which diffusion and consolidation of the layers take place. The surfaces are characterised by XRD, SEM, and micro-indentation; showing diffusion areas of between 40 and 85 microns with clear microstructural changes as well as higher hardness values. [less ▲]

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See detailGastrointestinal Parasites in Captive and Free-ranging Cebus albifrons in the Western Amazon, Ecuador.
Martin, Sarah ULg; Carrillo Bilbao, Gabriel Alberto; Ramirez, William et al

in International Journal for Parasitology: Parasites and Wildlife (2017)

Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the white-headed capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness ... [more ▼]

Currently, there is a lack of surveys that report the occurrence of gastrointestinal parasites in the white-headed capuchin monkey (Cebus albifrons). We therefore assessed the presence and richness (= number of different parasite genera) of parasites in C. albifrons in wildlife refuges (n = 11) and in a free-ranging group near a human village (n = 15) in the Ecuadorian Amazon. In the 78 samples collected (median of 3 samples per animal), we identified a total of 6 genera of gastrointestinal parasites, representing protozoa, nematodes, acantocephalan and cestodes. We observed a high prevalence (84%) across the 26 individuals, with the most prevalent parasite being Strongyloides sp. (76.9%), followed by Hymenolepis sp. (38.5%) and Prosthenorchis elegans (11.5%). We found Entamoeba histolytica/dispar/moskovskii/nuttalli and Capillaria sp. in only a minority of the animals (3.8%). In addition, we observed unidentified strongyles in approximately one-third of the animals (34.6%). We found a total of 6 parasite genera for the adult age group, which showed higher parasite richness than the subadult age group (5) and the juvenile age group (3). Faecal egg/cyst counts were not significantly different between captive and free-ranging individuals or between sexes or age groups. The free-ranging group had a higher prevalence than the captive group; however, this difference was not significant. The only genus common to captive and free-ranging individuals was Strongyloides sp. The high prevalence of gastrointestinal parasites and the presence of Strongyloides in both populations support results from previous studies in Cebus species. This high prevalence could be related to the high degree of humidity in the region. For the free-ranging group, additional studies are required to gain insights into the differences in parasite prevalence and intensity between age and sex groups. Additionally, our study demonstrated that a serial sampling of each individual increases the test sensitivity. [less ▲]

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See detailAccounting for Price Endogeneity in Airline Itinerary Choice Models: An Application to Continental U.S. Markets
Lurkin, Virginie ULg; Garrow, Laurie; Higgins, Matthew et al

in Transportation Research. Part A : Policy & Practice (2017), 100

Network planning models, which forecast the profitability of airline schedules, support many critical decisions, including equipment purchase decisions. Network planning models include an itinerary choice ... [more ▼]

Network planning models, which forecast the profitability of airline schedules, support many critical decisions, including equipment purchase decisions. Network planning models include an itinerary choice model which is used to allocate air total demand in a city pair to different itineraries. Multinomial logit (MNL) models are commonly used in practice and capture how individuals make trade-offs among different itinerary attributes; however, none that we are aware of account for price endogeneity. This study formulates an itinerary choice model that is consistent with those used by industry and corrects for price endogeneity using a control function that uses several types of instrumental variables. We estimate our models using database of more than 3 million tickets provided by the Airlines Reporting Corporation. Results based on Continental U.S. markets for May 2013 departures show that models that fail to account for price endogeneity overestimate customers’ value of time and result in biased price estimates and incorrect pricing recommendations. The size and comprehensiveness of our database allows us to estimate highly refined departure time of day preference curves that account for distance, direction of travel, the number of time zones traversed, departure day of week and itinerary type (outbound, inbound or one-way). These time of day preference curves can be used by airlines, researchers, and government organizations in the evaluation of different policies such as congestion pricing. [less ▲]

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See detailEvolution and diversity of ram-suction feeding in damselfishes (Pomacentridae)
Olivier, Damien ULg; Gajdzik, Laura ULg; Parmentier, Eric ULg et al

in Organisms Diversity & Evolution (2017), 17

The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily ... [more ▼]

The cerato-mandibular (c-md) ligament is a synapomorphy within Pomacentridae that creates a tight link between the lower jaws and the hyoid bars. However, this morphological trait has been secondarily lost in multiple lineages during evolution. A previous study revealed that the loss of this trait acted as a release of evolutionary constraints, leading to a cascade of morphological changes such elongated buccal jaws and a slender body. Ecomorphological interpretations suggested the loss of the c-md ligament has ultimately led to a new adaptive peak in zooplanktivory through an optimization of the ram feeding mode associated with a specialization in pelagic feeding. Here, we tested these hypotheses by comparing functional and diet diversity between damselfish species with and without the c-md ligament. Although species lacking the c-md ligament presented a conserved kinematic pattern resulting from high ram and low suction performances, our results did not support an optimization of the ram feeding mode. Indeed, some species with the c-md ligament showed the same or exceeded the ram performance of species without the c-md ligament. The species with the c-md ligament had a more diverse kinematic pattern exploring the entire ram-suction functional range in damselfishes. Finally, our results did not show any diet variations associated with the loss of the c-md ligament. Our study furthers the understanding of how a morphological trait has shaped, by its presence or absence, the ecomorpho-functional diversification of Pomacentridae. [less ▲]

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See detailHistoire du thymus : d'un organe vestigial à la programmation de la tolérance immunitaire
Geenen, Vincent ULg

in Medecine Sciences : M/S (2017), 33(6-7), 634-644

This synthesis presents the most important disruptions of conceptions about the thymus since its discovery in Antique Greece. For centuries, the thymus has been considered as a vestigial organ, and its ... [more ▼]

This synthesis presents the most important disruptions of conceptions about the thymus since its discovery in Antique Greece. For centuries, the thymus has been considered as a vestigial organ, and its role in T-lymphocyte differentiation has been proposed only in the 1960’s. Most recent studies attribute to the thymus an essential and unique role in the programming of central immunological self-tolerance. The basal mechanism implicated in this function is the transcription in thymic epithelium of genes encoding precursors of self-antigens. Processing of these latters leads to presentation of self-antigens by the major histocompatibility complex (MHC) machinery expressed by thymic epithelial and dendritic cells. During fetal life, this presentation drives negative selection of T-cell clones harboring receptors with high affinity for these complexes MHC/self-antigen. After birth, this presentation promotes the generation of regulatory T cells specific for these complexes. A number of studies, as well as the identification of Aire and Fezf2 genes, have shown that a thymus dysfunction plays a crucial role in the development of organ-specific autoimmunity. [less ▲]

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See detailMapping Soil Organic Carbon stocks and estimating uncertainties at the regional scale following a legacy sampling strategy (Southern Belgium, Wallonia)
Chartin, Caroline; Stevens, Antoine; Goidts, Esther et al

in Geoderma Regional (2017), 9

The quantification and the spatialisation of reliable SOC stocks (Mg C ha− 1) and total stock (Tg C) baselines and associated uncertainties are fundamental to detect the gains or losses in SOC, and to ... [more ▼]

The quantification and the spatialisation of reliable SOC stocks (Mg C ha− 1) and total stock (Tg C) baselines and associated uncertainties are fundamental to detect the gains or losses in SOC, and to locate sensitive areas with low SOC levels. Here, we aim to both quantify and spatialize SOC stocks at regional scale (southern Belgium) based on data from one non-design-based or model-based sampling scheme. To this end, we developed a computation procedure based on Digital Soil Mapping techniques and stochastic simulations (Monte-Carlo) allowing the estimation of multiple (here, 10,000) independent spatialized datasets. The computation of the prediction uncertainty accounts for the errors associated to both the estimations of i) SOC stocks and ii) parameters of the spatial model. Based on these 10,000 individuals, median SOC stocks and 90% prediction intervals were computed for each pixel, as well as total SOC stocks and their 90% prediction intervals for selected sub-areas and for the entire study area. Hence, a Generalised Additive Model (GAM) explaining 69.3% of the SOC stock variance was calibrated and then validated (R2 = 0.64). The model overestimated low SOC stock (below 50 Mg C ha− 1) and underestimated high SOC stock (especially those above 100 Mg C kg− 1). A positive gradient of SOC stock occurred from the northwest to the center of Wallonia with a slight decrease on the southernmost part, correlating to the evolution of precipitation and temperature (along with elevation) and dominant land use. At the catchment scale higher SOC stocks were predicted on valley bottoms, especially for poorly drained soils under grassland. Mean predicted SOC stocks for cropland and grassland in Wallonia were of 26.58 Tg C (SD 1.52) and 43.30 Tg C (2.93), respectively. The procedure developed here allowed to predict realistic spatial patterns of SOC stocks all over agricultural lands of southern Belgium and to produce reliable statistics of total SOC stocks for each of the 20 combinations of land use/agricultural regions of Wallonia. This procedure appears useful to produce soil maps as policy tools in conducting sustainable management at regional and national scales, and to compute statistics which comply with specific requirements of reporting activities. [less ▲]

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See detailPeriod–luminosity relations of fast-rotating B-type stars in the young open cluster NGC 3766
Saio, H.; Ekström, S.; Mowlavi, N. et al

in Monthly Notices of the Royal Astronomical Society (2017), 467(4), 3864-3873

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We ... [more ▼]

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We compare the properties of prograde sectoral g and retrograde r modes excited by the κ mechanism at the Fe opacity peak with the newly discovered period–luminosity relation that is obeyed by a group of fast-rotating B-type stars in the young open cluster NGC 3766. The observed relation consists of two sequences in the period versus magnitude diagram, at periods shorter than 0.5 d. We find that this property is consistent with similar period–luminosity relations predicted for excited sectoral prograde g modes of azimuthal orders m = −1 and −2 in fast-rotating stars along an isochrone. We further show that some of the rapidly rotating stars that have photometric variability with periods longer than a day may be caused by r-mode pulsation predicted to be excited in these stars. One fast-rotating star, in particular, shows both short and long periods that can be explained by the simultaneous excitation of g- and r-mode pulsations in models of fast-rotating stars. [less ▲]

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See detailSartre, hériter de Heidegger ? Quelques remarques à propos du circuit de l'ipséité dans "L'Être et le Néant" [titre provisoire]
Recchia, Fabio ULg

in Revista Ética e Filosofia Política (2017), 1

Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa ... [more ▼]

Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa théorie du « circuit de l’ipséité » de la conscience. Quant à mon objectif, il s’agira de faire le point sur le processus de maturation intellectuelle à l’issue duquel Sartre conçut l’ipséité comme un circuit. Ainsi je mets en évidence que certaines des réflexions de Heidegger, Bergson et Mauss, sur la notion d’identité personnelle ont constitué les héritages philosophiques mobilisés et transformés par la théorie sartrienne de l’ipséité. [less ▲]

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See detailSolidarité intergénérationnelle chez les migrantes sud-américaines
Vivas Romero, Maria ULg; Piddiu, Luca

in Voix Solidaires (2017), 22(été 2017), 14-16

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See detailTrop beau pour être vrai ? Quand un effet largement positif n’est pas nécessairement conclusif
Henrard, Gilles ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2017)

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See detailEditorial
Dewals, Benjamin ULg

in Proceedings of ICE : Water Management (2017), 170(WM3), 109-110

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See detailQu'est-ce que l'eau souterraine ?
Ruthy, Ingrid ULg; Brouyère, Serge ULg

in Eco Karst (2017), 108

L'eau souterraine et le karst. Quelques définitions et concepts-clés

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See detailElectro dynamic fragmentation of printed wiring boards as a preparation tool for their recycling
Martino, Rémi; Iseli, Cedric; Gaydardzhiev, Stoyan ULg et al

in Minerals Engineering (2017), 107

The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed ... [more ▼]

The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed downstream in a more efficient way especially when value-added End-of-Life (EoL) electronic equipment is recycled. The aim of this study was to assess the benefits of the EDF technology towards processing of EoL printed wiring boards (PWBs) in view their recyclability. Printed wiring boards were comminuted using EDF at three different settings and with a hammer mill for comparative experiment. The products coming out were characterized by optical microscopy, SEM and liberation oriented leaching. Subsamples from the various EDF stages were inspected to investigate the progress of cracks and degree of copper layers exposure. The different energy levels used during the EDF processing have resulted in different degrees of PWBs damages, starting from components removal to entire structure perturbation and size reduction. EDF has resulted in generation of a lesser amount of fines, however the optimal approach in view energy efficient post-processing of the studied PWBs was the combination between single-stage EDF for components removal only with subsequent shredding of the depopulated boards. [less ▲]

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See detailThe diagnostic value of rescaled renal biomarker serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate.
Pottel, H; Dubourg, L; Schaeffner, E et al

in Clinica Chimica Acta (2017), 471

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See detailNumerical modelling of micro-plasto-hydrodynamic lubrication in plane strip drawing
Carretta, Yves ULg; Bech, Jakob; Legrand, Nicolas et al

in Tribology International (2017), 110

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming ... [more ▼]

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming. The present approach is divided in two steps. First, a simulation at the macroscopic level is conducted. Then, a second simulation highlighting microscopic liquid lubrication mechanisms is achieved using boundary conditions provided by the first model. These fluid-structure interaction computations are made possible through the use of the Arbitrary Lagrangian Eulerian (ALE) formalism. The developed methodology is validated by comparison to experimental measurements conducted in plane strip drawing. The effect of physical parameters like the drawing speed, the die angle and the strip thickness reduction is investigated. The numerical results show good agreement with experiments. [less ▲]

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See detailA computational stochastic multiscale methodology for MEMS structures involving adhesive contact
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Tribology International (2017), 110

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS ... [more ▼]

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS. Because the magnitudes of the adhesive forces strongly depend on the surface interaction distances, which in turn evolve with the roughness of the contacting surfaces, the involved structural behaviors suffer from a scatter. To numerically predict the probabilistic behaviors of structures involving adhesion, the proposed method introduces stochastic meso-scale random apparent contact forces which can be integrated into a stochastic finite element model. Because the evaluation of their realizations is expensive, a generator for the random apparent contact force using the polynomial chaos expansion is constructed in an efficient way. [less ▲]

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See detailIdentification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors
Larsen, Anja Probst; Fièvre, Sabine; Frydenvang, Karla et al

in Molecular Pharmacology (2017), 91

Kainate receptors (KARs) consist of a class of ionotropic gluta- mate receptors, which exert diverse pre- and postsynaptic functions through complex signaling regulating the activity of neural circuits ... [more ▼]

Kainate receptors (KARs) consist of a class of ionotropic gluta- mate receptors, which exert diverse pre- and postsynaptic functions through complex signaling regulating the activity of neural circuits. Whereas numerous small-molecule positive allosteric modulators of the ligand-binding domain of (S)-2- amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptors have been reported, no such ligands are avail- able for KARs. In this study, we investigated the ability of three benzothiadiazine-based modulators to potentiate glutamate-evoked currents at recombinantly expressed KARs. 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1- dioxide (BPAM344) potentiated glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 mM), with an EC50 of 79 mM. BPAM344 markedly decreased desensitization kinetics (from 5.5 to 775 ms), whereas it only had a minor effect on deactivation kinetics. 4-cyclopropyl-7-hydroxy-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM521) potentiated the recorded peak current amplitude of GluK2a 12-fold at a concen- tration of 300 mM with an EC50 value of 159 mM, whereas no potentiation of the glutamate-evoked response was observed for 7-chloro-4-(2-fluoroethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BPAM121) at the highest concentration of modulator tested (300 mM). BPAM344 (100 mM) also potentiated the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15- fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold). X-ray structures of the three modulators in the GluK1 ligand-binding domain were determined, locating two modulator- binding sites at the GluK1 dimer interface. In conclusion, this study may enable the design of new positive allosteric modulators selective for KARs, which will be of great interest for further investigation of the function of KARs in vivo and may prove useful for pharmacologically controlling the activity of neuronal networks. [less ▲]

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See detailPressure-induced insulator–metal transition in EuMnO3
Qiu, Ruihao ULg; Bousquet, Eric ULg; Cano, Andres

in Journal of Physics : Condensed Matter (2017), 29

We study the influence of external pressure on the electronic and magnetic structure of EuMnO3 from first-principles calculations. We find a pressure-induced insulator– metal transition at which the ... [more ▼]

We study the influence of external pressure on the electronic and magnetic structure of EuMnO3 from first-principles calculations. We find a pressure-induced insulator– metal transition at which the magnetic order changes from A-type antiferromagnetic to ferromagnetic with a strong interplay with Jahn–Teller distortions. In addition, we find that the non-centrosymmetric E*-type antiferromagnetic order can become nearly degenerate with the ferromagnetic ground state in the high-pressure metallic state. This situation can be exploited to promote a magnetically-driven realization of a non-centrosymmetric (ferroelectric-like) metal. [less ▲]

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See detailA decision support tool for transient stability preventive control
Pertl, Michael; Weckesser, Johannes ULg; Rezkalla, Michel et al

in Electric Power Systems Research (2017), 147

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the ... [more ▼]

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the state of the power system in terms of transient stability. A time-domain approach is used to assess the transient stability for potentially critical faults. Potential critical fault locations are identified by a critical bus screening through analysis of pre-disturbance steady-state conditions. The identified buses are subject to a fast critical contingency screening determining the actual critical contingencies/buses. These two screenings aim at reducing the computational burden of the assessment, since only contingencies considered as critical are taken into account. The critical clearing times for the critical contingencies are determined. A preventive re-dispatch of generators to ensure a predefined minimum critical clearing time for faults at all buses is proposed, while costs are minimized. The results of the assessment are presented to the control room operator, who decides to accept the suggested dispatch or to repeat the assessment considering additional user-specific constraints. The effectiveness of the proposed method is demonstrated on a standard nine-bus and the New England test system. [less ▲]

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See detailWhy Collaborative Care for Depressed Patients is so Difficult: A Belgian Qualitative Study
Van den Broeck, Kris; Ketterer, Frédéric ULg; Remmen, Roy et al

in International Journal of Integrated Care [=IJIC] (2017), 17(2), 1-9

Although current guidelines recommend collaborative care for severely depressed patients, few patients get adequate treatment. In this study we aimed to identify the thresholds for interdisciplinary ... [more ▼]

Although current guidelines recommend collaborative care for severely depressed patients, few patients get adequate treatment. In this study we aimed to identify the thresholds for interdisciplinary collaboration amongst practitioners when treating severely depressed patients. In addition, we aimed to identify specific and feasible steps that may add to improved collaboration amongst first and second level Belgian health care providers when treating depressed patients. In two standard focus groups (n = 8; n = 12), general practitioners and psychiatrists first outlined current practice and its shortcomings. In a next phase, the same participants were gathered in nominal groups to identify and prioritise steps that could give rise to improved collaboration. Thematic analyses were performed. Though some barriers for interdisciplinary collaboration may seem easy to overcome, participants stressed the importance of certain boundary conditions on a macro- (e.g., financing of care, secure communication technology) and meso-level (e.g., support for first level practitioner). Findings are discussed against the background of frameworks on collaboration in healthcare and recent developments in mental health care. [less ▲]

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See detailValidation of a new elastoplastic constitutive model dedicated to the cyclic behaviour of brittle rock materials
Cerfontaine, Benjamin ULg; Charlier, Robert ULg; Collin, Frédéric ULg et al

in Rock Mechanics & Rock Engineering (2017)

Old mines or caverns may be used as reservoirs for fuel/gas storage or in the context of large-scale energy storage. In the first case, oil or gas is stored on annual basis. In the second case pressure ... [more ▼]

Old mines or caverns may be used as reservoirs for fuel/gas storage or in the context of large-scale energy storage. In the first case, oil or gas is stored on annual basis. In the second case pressure due to water or compressed air varies on a daily basis or even faster. In both cases a cyclic loading on the cavern’s/mine’s walls must be considered for the design. The complexity of rockwork geometries or coupling with water flow requires finite element modelling and then a suitable constitutive law for the rock behaviour modelling. This paper presents and validates the formulation of a new constitutive law able to represent the inherently cyclic behaviour of rocks at low confinement. The main features of the behaviour evidenced by experiments in the literature depict a progressive degradation and strain of the material with the number of cycles. A constitutive law based on a boundary surface concept is developed. It represents the brittle failure of the material as well as its progressive degradation. Kinematic hardening of the yield surface allows the modelling of cycles. Isotropic softening on the cohesion variable leads to the progressive degradation of the rock strength. A limit surface is introduced and has a lower opening than the bounding surface. This surface describes the peak strength of the material andallows the modelling of a brittle behaviour. In addition a fatigue limit is introduced such that no cohesion degradation occurs if the stress state lies inside this surface. The model is validated against three different rock materials and types of experiments. Parameters of the constitutive laws are calibrated against uniaxial tests on Lorano marble, triaxial test on a sandstone and damage-controlled test on Lac du Bonnet granite. The model is shown to reproduce correctly experimental results, especially the evolution of strain with number of cycles. [less ▲]

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See detailTemporality of Features in Near-Death Experience Narratives
Martial, Charlotte ULg; Cassol, Helena ULg; Antonopoulos, Georgios ULg et al

in Frontiers in Human Neuroscience (2017)

Background: After an occurrence of a Near-Death Experience (NDE), Near- Death Experiencers (NDErs) usually report extremely rich and detailed narratives. Phenomenologically, a NDE can be described as a ... [more ▼]

Background: After an occurrence of a Near-Death Experience (NDE), Near- Death Experiencers (NDErs) usually report extremely rich and detailed narratives. Phenomenologically, a NDE can be described as a set of distinguishable features. Some authors have proposed regular patterns of NDEs, however, the actual temporality sequence of NDE core features remains a little explored area. Objectives: The aim of the present study was to investigate the frequency distribution of these features (globally and according to the position of features in narratives) as well as the most frequently reported temporality sequences of features. Methods: We collected 154 French freely expressed written NDE narratives (i.e., Greyson NDE scale total score 7/32). A text analysis was conducted on all narratives in order to infer temporal ordering and frequency distribution of NDE features. Results: Our analyses highlighted the following most frequently reported sequence of consecutive NDE features: Out-of-Body Experience, Experiencing a tunnel, Seeing a bright light, Feeling of peace. Yet, this sequence was encountered in a very limited number of NDErs. Conclusion: These findings may suggest that NDEs temporality sequences can vary across NDErs. Exploring associations and relationships among features encountered during NDEs may complete the rigorous definition and scientific comprehension of the phenomenon. [less ▲]

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See detailActualités dans le traitement des tendinopathies
Sauvant, Céline; Kaux, Jean-François ULg

in Journal de Traumatologie du Sport (2017), 34(2), 99-107

Tendon injuries caused by overuse have been described as “tendinitis” for years before it was demonstrated that the histopathological process wasnot due to intratendinous inflammation. Cook and Purdam ... [more ▼]

Tendon injuries caused by overuse have been described as “tendinitis” for years before it was demonstrated that the histopathological process wasnot due to intratendinous inflammation. Cook and Purdam proposed a continuum model of tendon pathology, which provides a better understandingof the condition and the possibility to adapt the treatment. This allows a better recovery and a lower recurrence rate of the tendinopathy. This articleis a review of current treatments used in clinical practice. [less ▲]

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See detailN-Glycosylation of an IgG antibody secreted by Nicotiana tabacum BY-2 cells can be modulated through co-expression of human β-1,4-galactosyltransferase
Navarre, Catherine; Smargiasso, Nicolas ULg; Duvivier, Laurent et al

in Transgenic Research (2017), 26(3), 375-384

Nicotiana tabacum BY-2 suspension cells have several advantages that make them suitable for the production of full-size monoclonal antibodies which can be purified directly from the culture medium ... [more ▼]

Nicotiana tabacum BY-2 suspension cells have several advantages that make them suitable for the production of full-size monoclonal antibodies which can be purified directly from the culture medium. Carbohydrate characterization of an antibody (Lo-BM2) expressed in N. tabacum BY-2 cells showed that the purified Lo-BM2 displays N-glycan homogeneity with a high proportion (>70%) of the complex GnGnXF glycoform. The stable co-expression of a human β-1,4-galactosyltransferase targeted to different Golgi sub-compartments altered Lo-BM2N-glycosylation and resulted in the production of an antibody that exhibited either hybrid structures containing a low abundance of the plant epitopes (α-1,3-fucose and β-1,2-xylose), or a large amount of galactose-extended N-glycan structures. These results demonstrate the suitability of stable N-glycoengineered N. tabacum BY-2 cell lines for the production of human-like antibodies. © 2017, Springer International Publishing Switzerland. [less ▲]

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See detailTraumatologie des sports olympiques de ballon en salle. Partie 1: le basket-ball
Kaux, Jean-François ULg; Roberjot, Mathieu; DELVAUX, François ULg et al

in Journal de Traumatologie du Sport (2017), 34(2), 108-113

Basketball, handball and volleyball are three indoor ball sports played in the Olympic Games. An important solicitation of the upper limbs is acommon characteristic of these three sports. The main ... [more ▼]

Basketball, handball and volleyball are three indoor ball sports played in the Olympic Games. An important solicitation of the upper limbs is acommon characteristic of these three sports. The main objective of this review of the literature is to analyze the types of injury occurring in thesethree indoor ball games, looking for the specific localizations and their potential causes. Each sport will be discussed in a specific publication.Basketball is a very popular sport with a growing number of participants. The intensity of the game has increased as it has become more physical,leading to an increasing number of injuries. Ankle sprain is the most common injury in basketball. Back pain, finger fracture and tendon injury(jumper’s knee) or knee injury (anterior cruciate ligament tears) are also common. The main mechanism of traumatic injury is direct contact withthe opponent (during games) but there is also an increasing number of over-solicitation injuries. The length of time players must avoid sportsactivities after injury depends on the type of injury involved. [less ▲]

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See detailMultimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting
Pansieri, Jonathan; Plissonneau, Marie; Stransky-Heilkron, Nathalie et al

in Nanomedicine (2017)

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See detailEpidemiology of chronic kidney disease: think (at least) twice!
DELANAYE, Pierre ULg; Glassock, RJ; De Broe, ME

in Clinical Kidney Journal (2017), 10(3), 370-374

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See detailInsect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae
Paul, Aman ULg; Frederich, Michel ULg; Caparros Megido, Rudy ULg et al

in Journal of Asia-Pacific Entomology (2017), 20(2), 337-340

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and ... [more ▼]

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and compared with those of Tenebrio molitor larvae. A. domesticus, Co. discolor, Ch. parallelus and T. molitor larvae were found to contain approximately 15%, 13%, 10% and 32% lipids on dry weight, respectively. The lipids from three Orthopterans contain much higher amounts of essential fatty acids than those of T. molitor larvae. The two Orthopterans of the suborder Ensifera i.e., A. domesticus and Co. discolor contain linoleic acid in major quantities, while Ch. parallelus of the suborder Caelifera, contain α-linolenic acid in major quantities. The consumption of linoleic and α-linolenic fatty acid is linked with numerous health promoting effects. The factors that contribute to differences in fatty acid profiles of these insects are being discussed. At last the nutritional parameters including polyunsaturated to saturated and omega 6 to omega 3 fatty acid ratios of these insect lipids are also being discussed to understand the potential role of these lipids in human nutrition. [less ▲]

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See detailGenetic parameters of mid-infrared methane predictions and their relationships with milk production traits in Holstein cattle
Kandel, Purna; Vanrobays, Marie-Laure; Vanlierde, Amélie et al

in Journal of Dairy Science (2017), 100(7), 5578-5591

Many countries have pledged to reduce greenhouse gases. In this context, the dairy sector is one of the identified sectors to adapt production circumstances to address socio-environmental constraints due ... [more ▼]

Many countries have pledged to reduce greenhouse gases. In this context, the dairy sector is one of the identified sectors to adapt production circumstances to address socio-environmental constraints due to its large carbon footprint related to CH4 emission. This study aimed mainly to estimate (1) the genetic parameters of 2 milk mid-infrared-based CH4 proxies [predicted daily CH4 emission (PME, g/d), and log-transformed predicted CH4 intensity (LMI)] and (2) their genetic correlations with milk production traits [milk (MY), fat (FY), and protein (PY) yields] from first- and second-parity Holstein cows. A total of 336,126 and 231,400 mid-infrared CH4 phenotypes were collected from 56,957 and 34,992 first- and second-parity cows, respectively. The PME increased from the first to the second lactation (433 vs. 453 g/d) and the LMI decreased (2.93 vs. 2.86). We used 20 bivariate random regression test-day models to estimate the variance components. Moderate heritability values were observed for both CH4 traits, and those values decreased slightly from the first to the second lactation (0.25 ± 0.01 and 0.22 ± 0.01 for PME; 0.18 ± 0.01 and 0.17 ± 0.02 for LMI). Lactation phenotypic and genetic correlations were negative between PME and MY in both first and second lactations (−0.07 vs. −0.07 and −0.19 vs. −0.24, respectively). More close scrutiny revealed that relative increase of PME was lower with high MY levels even reverting to decrease, and therefore explaining the negative correlations, indicating that higher producing cows could be a mitigation option for CH4 emission. The PME phenotypic correlations were almost equal to 0 with FY and PY for both lactations. However, the genetic correlations between PME and FY were slightly positive (0.11 and 0.12), whereas with PY the correlations were slightly negative (−0.05 and −0.04). Both phenotypic and genetic correlations between LMI and MY or PY or FY were always relatively highly negative (from −0.21 to −0.88). As the genetic correlations between PME and LMI were strong (0.71 and 0.72 in first and second lactation), the selection of one trait would also strongly influence the other trait. However, in animal breeding context, PME, as a direct quantity CH4 proxy, would be preferred to LMI, which is a ratio trait of PME with a trait already in the index. The range of PME sire estimated breeding values were 22.1 and 29.41 kg per lactation in first and second parity, respectively. Further studies must be conducted to evaluate the effect of the introduction of PME in a selection index on the other traits already included in this index, such as, for instance, fertility or longevity. [less ▲]

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See detailGreen mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease
Ciolek, Justyna; Reinfrank, Helen; Quinton, Loïc ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2017)

Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin ... [more ▼]

Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 other G-protein–coupled receptors or on 15 ionic channels. Mambaquaretin-1 is a full antagonist of the V2R activation pathways studied: cAMP production, beta-arrestin interaction, and MAP kinase activity. This peptide adopts the Kunitz fold known to mostly act on potassium channels and serine proteases. Mambaquaretin-1 interacts selectively with the V2R through its first loop, in the same manner that aprotinin inhibits trypsin. Injected in mice, mambaquaretin-1 increases in a dose-dependent manner urine outflow with concomitant reduction of urine osmolality, indicating a purely aquaretic effect associated with the in vivo blockade of V2R. CD1-pcy/pcy mice, a juvenile model of PKD, daily treated with 13 μ𝝁g of mambaquaretin-1 for 99 d, developed less abundant (by 33%) and smaller (by 47%) cysts than control mice. Neither tachyphylaxis nor apparent toxicity has been noted. Mambaquaretin-1 represents a promising therapeutic agent against PKDs. [less ▲]

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See detailMagnetic Shielding Above 1 T at 20 K With Bulk, Large Grain YBCO Tubes Made by Buffer-aided Top Seeded Melt Growth
Wera, Laurent ULg; Fagnard, Jean-François ULg; Kumar, Numbury Devendra et al

in IEEE Transactions on Applied Superconductivity (2017), 27(4),

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and ... [more ▼]

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and are observed to reduce axial flux densities of 1.5 T by a factor of 100 at 20 K. Such performances are comparable in magnitude to the record threshold inductions reported for bulk MgB2 and Bi-2212 materials at lower temperatures. Magnetic shielding measurements for open and closed tubes at 77 K also show that the presence of the cap improves substantially the shielding performance at the closed extremity since it reduces the penetration through the open end. This fabrication technique is extremely promising for shielding “dc” stray fields generated by HTS magnets operated in a temperature range obtained by cryocoolers, liquid hydrogen (20 K) or liquid neon (27 K). [less ▲]

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See detailLuciobarbus chelifensis and L. mascarensis, two new species from Algeria (Teleostei: Cyprinidae)
Brahimi, Amina; Freyhof, Jörg; Henrard, Arnaud et al

in Zootaxa (2017), 4277(1), 32-50

Cyprinids of the genus Luciobarbus are the most abundant and widespread fishes in most freshwater ecosystems in the Maghreb. In the Mediterranean basin of Morocco, Algeria and Tunisia, all species of ... [more ▼]

Cyprinids of the genus Luciobarbus are the most abundant and widespread fishes in most freshwater ecosystems in the Maghreb. In the Mediterranean basin of Morocco, Algeria and Tunisia, all species of Luciobarbus—with exception of L. guercifensis—are superficially very similar and are distinguished mostly by minor morphometric characters. Molecular characters distinguish all species well and nine species are recognised from the area, two of them described here. Luciobarbus chelifensis, from the Chelif River drainage in Algeria, is distinguished by having 41–43+1–2 lateral line scales and a very short anal fin (18–19% SL). Luciobarbus mascarensis, from the Macta River drainage in Algeria, is distinguished by having usually 41+1–2 lateral line scales, a long anal-fin (19–22%) and a short caudal peduncle (15–17% SL). An identification key is given for all African Mediterranean Luciobarbus species except for L. callensis and L. rifensis, which could not be distinguished. [less ▲]

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See detailCKD-EPI equation: a suitable glomerular filtration rate estimate for drug dosing in HIV-infected patients
Gagneux-Brunon, A; Bothelo-Nevers, E; DELANAYE, Pierre ULg et al

in Médecine et Maladies Infectieuses (2017), 47(4), 266-270

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See detailDélit sexuel à l'adolescence : quels traitements judicaires ?
Glowacz, Fabienne ULg; Camarda, Sabrina

in Revue Internationale de Criminologie et de Police Technique et Scientifique [= RICPTS] (2017), LXX(2), 151-166

The purpose of this study was to explore the judicial treatment given to juvenile that commited sexual offenses. The decisions taken by Crown and the juvenile Court are reffered. We tried to answer this ... [more ▼]

The purpose of this study was to explore the judicial treatment given to juvenile that commited sexual offenses. The decisions taken by Crown and the juvenile Court are reffered. We tried to answer this goal by reviewing more specifically the case of three district of Belgium. The study is based on the analysis of 150 judicial records that allowed to profile the AAICS and the nature of their offenses, and then to identify the personal and offense characteristics associated with the orientations given to a at the level of the courts As well as substantive proceedings; The results show that a large part of our sample (66%) was not followed up and only 24% of cases were referred to the Youth Court. These are the offenses of child sexual abuse, mixed sexual abuse (children and peers), and the rape and offenses with violence that are most likely to be referred to the youth Court. Among the particularly decisive variables associated with the orientations and judicial measures, there were judicial antecedents (sexual or not), problematic behavior at school and multiple fugues. These factors are recognized as risk factors for general delinquency and also appear as determinants in the application of judicial measures for juvenile sex offenders. [less ▲]

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See detailAnisotropic modelling of Opalinus Clay behaviour: from triaxial tests to gallery excavation application
Bertrand, François ULg; Collin, Frédéric ULg

in Journal of Rock-Mechanics and Geotechnical Engineering (2017)

Deep repository in geological formations is the preferential solution considered by many countries to manage high-level nuclear wastes. In Switzerland, the Opalinus Clay is a candidate host rock. In this ... [more ▼]

Deep repository in geological formations is the preferential solution considered by many countries to manage high-level nuclear wastes. In Switzerland, the Opalinus Clay is a candidate host rock. In this context, in situ and laboratory tests are conducted on Opalinus Clay to demonstrate the feasibility of deep disposal in this argillaceous formation. This paper presents a constitutive model able to fit the experimental data obtained from some triaxial tests conducted by Jahns [1] on cores from bore hole Schlattingen SLA- 1. The elasto-plastic behaviour of Opalinus Clay is reproduced thanks to a Drucker-Prager model, taking into account the anisotropy behaviour of this sedimentary rock. The objective is to employ a single set of parameters representative of the material. In a second version of the model, the stress-dependency of the elastic properties and damage are taken into account. Finally, the parameters calibrated with experimental tests are used to simulate the excavation of a gallery with a second gradient approach. [less ▲]

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See detailLE CONTRÔLE DES NORMES RELATIVES À LA MODÉRATION DES RÉMUNÉRATIONS AU REGARD DU DROIT DE NÉGOCIATION COLLECTIVE
Clesse, Jacques ULg; Kéfer, Fabienne ULg

in Revue de Droit Social = Tijdschrift voor Sociaal Recht (2017), (1-2), 89-112

En moins d’une semaine, deux lois ayant un impact important sur le montant des salaires sont entrées en vigueur. La loi du 23 avril 2015 concernant la promotion de l’emploi impose un saut d’index. La loi ... [more ▼]

En moins d’une semaine, deux lois ayant un impact important sur le montant des salaires sont entrées en vigueur. La loi du 23 avril 2015 concernant la promotion de l’emploi impose un saut d’index. La loi du 28 avril 2015 établit la marge maximale pour l’évolution du coût salarial pour les années 2015 et 2016. Ces deux lois ont provoqué une forte opposition de la part des organisations syndicales. Traditionnellement, en Belgique, la formation des salaires relève de l’autonomie des partenaires sociaux. Par la voie des conventions collectives de travail, ceux-ci établissent le montant minimum des rémunérations au niveau du pays et des secteurs d’activité. Les organisations syndicales ont vu dans ces deux lois une atteinte grave portée par l’État à la concertation sociale. Après une première partie décrivant, sans pouvoir être exhaustive, les mécanismes de modération des salaires utilisés en Belgique depuis 1976, la contribution a pour objet d’examiner la régularité juridique de ces deux lois en regard du droit de négociation collective. Ce droit, qui constitue l’un des fondements juridiques du dialogue social et de l’action syndicale, appartient au catalogue des droits fondamentaux puisqu’il a été reconnu par différents instruments internationaux ainsi que par la Constitution de la Belgique. [less ▲]

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See detailThe role of market-oriented institutions in the deployment of renewable energies: evidences from Europe
Jacqmin, Julien ULg

in Applied Economics (2017)

Focusing on European countries, this article investigates the link between market-oriented institutions, as measured by the Economic Freedom Index, and the production of energy from renewable sources. A ... [more ▼]

Focusing on European countries, this article investigates the link between market-oriented institutions, as measured by the Economic Freedom Index, and the production of energy from renewable sources. A dynamic panel approach shows that this correlation is positive and significant while the subcomponents of the Economic Freedom Index reveal that not all market-oriented institutions have a similar impact. Indeed, long-term price stability and freedom to trade boost the reliance on renewable energies whereas the importance given to markets rather than governments has no significant impact. [less ▲]

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See detailPour un droit fondamental au logement : émergence et nuances
Quintart, Aurélie ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2017)

The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for ... [more ▼]

The fundamental right to housing is written in article 23 of our Constitution along with others social and economical rights since 1994. It is said to be a necessary component for the right to respect for human dignity. For the last decades, the right to housing has been quoted in many international declarations and conventions. However we still wonder: what is the real impact of this right to housing? How effective can it be? What interpretation can we give to case-law in this regard? We would like to bring some ideas and answer to the debate. Our article analyses the right to housing nowadays, as emerging out of treaties, laws and the international and national case-law. [less ▲]

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