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See detailPerformance, robustness and sensitivity analysis of the nonlinear tuned vibration absorber
Detroux, Thibaut ULg; Habib, Giuseppe ULg; Masset, Luc ULg et al

in Mechanical Systems & Signal Processing (2015), 60-61

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of ... [more ▼]

The nonlinear tuned vibration absorber (NLTVA) is a recently developed nonlinear absorber which generalizes Den Hartog׳s equal peak method to nonlinear systems. If the purposeful introduction of nonlinearity can enhance system performance, it can also give rise to adverse dynamical phenomena, including detached resonance curves and quasiperiodic regimes of motion. Through the combination of numerical continuation of periodic solutions, bifurcation detection and tracking, and global analysis, the present study identifies boundaries in the NLTVA parameter space delimiting safe, unsafe and unacceptable operations. The sensitivity of these boundaries to uncertainty in the NLTVA parameters is also investigated. [less ▲]

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See detailA study of composite laminates failure using an anisotropic gradient-enhanced damage mean-field homogenization model
Wu, Ling ULg; Sket, Federico; Molina-Aldareguia, Jon M et al

in Composite Structures (2015), 126

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized ... [more ▼]

The failure of carbon fiber reinforced epoxy laminates is studied using an anisotropic gradient-enhanced continuum damage model embedded in a mean-field homogenization scheme. In each ply, a homogenized material law is used to capture the intra-laminar failure. The anisotropy of the homogenized material model results from the homogenization method and from the reformulation of the non-local continuum damage theory to account for the material anisotropy. As a result the damage propagation direction in each ply is predicted with accuracy as compared to the experimental results, while the problems of losing uniqueness and strain localization, which occur in classical finite element simulations when strain softening of materials is involved, can be avoided. To model the delamination process, the hybrid discontinuous Galerkin/extrinsic cohesive law method is introduced at the ply interfaces. This hybrid method avoids the need to propagate topological changes in the mesh with the propagation of the delamination while it preserves the consistency and stability in the un-cracked interfaces. As a demonstration, open-hole coupons with different stacking sequences are studied numerically and experimentally. Both the intra- and inter-laminar failure patterns are shown to be well captured by the computational framework. [less ▲]

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See detailCharacterizing activity sequences using Profile Hidden Markov Models
Liu, Feng; Janssens, Davy; Cui, JianXun et al

in Expert Systems with Applications (2015), 42(13), 57055722

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment ... [more ▼]

In literature, activity sequences, generated from activity-travel diaries, have been analyzed and classified into clusters based on the composition and ordering of the activities using Sequence Alignment Methods (SAM). However, using these methods, only the frequent activities in each cluster are extracted and qualitatively described; the infrequent activities and their related travel episodes are disregarded. Thus, to quantify the occurrence probabilities of all the daily activities as well as their sequential orders, we develop a novel process to build multiple alignments of the sequences and subsequently derive profile Hidden Markov Models (pHMMs). This process consists of 4 major steps. First, activity sequences are clustered based on a pre-defined scheme. The frequent activities along with their sequential orders are then identified in each cluster, and they are subsequently used as a template to guide the construction of a multiple alignment of the cluster of sequences. Finally, a pHMM is employed to convert the multiple alignment into a position-specific scoring system, representing the probability of each frequent activity at each important position of the alignment as well as the probabilities of both insertion and deletion of infrequent activities. By applying the derived pHMMs to a set of activity-travel diaries collected in Belgium as well as a group of mobile phone call location data recorded in Switzerland, the potential and effectiveness of the models in capturing the sequential features of each cluster and distinguishing them from those of other clusters, are demonstrated. The proposed method can also be utilized to improve activity-based transportation model validation and travel survey designs. Furthermore, it offers a wide application in characterizing a group of any related sequences, particularly sequences varying in length and with a high frequency of short sequences that are typically present in human behavior. [less ▲]

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See detailDevelopment, validation and comparison of NIR and Raman methods for the identification and assay of poor-quality oral quinine drops.
Mbinze Kidenge, Jérémie; Sacre, Pierre-Yves ULg; Yemoa, Achille et al

in Journal of Pharmaceutical & Biomedical Analysis (2015), 111

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient ... [more ▼]

Poor quality antimalarial drugs are one of the public’s major health problems in Africa. The depth of this problem may be explained in part by the lack of effective enforcement and the lack of efficient local drug analysis laboratories. To tackle part of this issue, two spectroscopic methods with the ability to detect and to quantify quinine dihydrochloride in children’s oral drops formulations were developed and validated. Raman and Near Infrared (NIR) spectroscopy were selected for the drug analysis due to their low cost, non-destructive and rapid characteristics. Both of the methods developed were successfully validated using the total error approach in the range of 50-150% of the target concentration (20% W/V) within the 10% acceptance limits. Samples collected on the Congolese pharmaceutical market were analyzed by both techniques to detect potentially substandard drugs. After a comparison of the analytical performance of both methods, it has been decided to implement the method based on NIR spectroscopy to perform the routine analysis of quinine oral drop samples in the Quality Control Laboratory of Drugs at the University of Kinshasa (DRC). [less ▲]

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See detailDrug loading of polymer implants by supercritical CO2 assisted impregnation: a review
Champeau, Mathilde; Thomassin, Jean-Michel ULg; Tassaing, Thierry et al

in Journal of Controlled Release (2015), 209

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has ... [more ▼]

Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has attracted growing attention to load Active Pharmaceutical Ingredients into polymer implants since it enables to recover a final implant free of any solvent residue and to operate under mild temperature which is suitable for processing with thermosensitive drugs. This paper is a review of the state-of-the-art and the application of the scCO2 assisted impregnation process to prepare drug-eluting implants. It introduces the process and presents its advantages for biomedical applications. The influences of the characteristics of the implied binary systems and of the experimental conditions on the drug loading are described. Then, the various current applications of this process for manufacturing drug-eluting implants are reviewed. Finally, the new emerging variations of this process are described. [less ▲]

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See detailVersion française de la Distress Tolerance Scale et de la Discomfort Intolerance Scale
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2015), 3(47),

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort ... [more ▼]

The perceived perspective of the distress tolerance refers to the perceived ability to experience and to withstand negative emotional states and/or other aversive sensations (e.g. physical discomfort). Two scales were developed to assess this construct: the Distress Tolerance Scale (DTS) and the Discomfort Intolerance Scale (DIS). The objective of this investigation is to present the validation of these two scales in French. 488 non-clinical adults completed an online survey assessing the distress tolerance and emotional regulation strategies. Factor analyses were performed to determine the factor structures of the French versions of these scales. CFA highlighted a four-factor solution (tolerance, absorption, appraisal, regulation) with one higher-order factor (general distress tolerance) as being the better fit for the DTS. CFA highlighted a two-factor solution (intolerance and avoidance) with one higher-order factor (general discomfort intolerance) as being the better fit for the DIS. Intern and extern validity were assessed and demonstrated good properties. [less ▲]

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See detailPolarization alignments of quasars from the JVAS/CLASS 8.4-GHz surveys
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Monthly Notices of the Royal Astronomical Society (2015), 450

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization ... [more ▼]

We test the hypothesis that the polarization vectors of flat-spectrum radio sources (FSRSs) from the JVAS/CLASS 8.4-GHz surveys are randomly oriented in the sky. A sample with robust polarization measurements is made with 4155 objects. Redshift information is known for 1531 of them. We performed two statistical analyses: one in two dimensions and the other in three dimensions when distance is available. We find significant large-scale alignments of polarization vectors for samples containing only quasars among the varieties of FSRS. While these correlations prove difficult to explain either by a physical effect or by biases in the data set, that the quasars that have significantly aligned polarization vectors are found in regions of the sky where optical polarization alignments were previously found is striking. [less ▲]

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See detailBiomechanical Analysis of Abdominal Injury in Tennis Serves. A Case Report
Tubez, François ULg; Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg et al

in Journal of Sports Science & Medicine (2015), 14

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is ... [more ▼]

The serve is an important stroke in any high level tennis game. A well-mastered serve is a substantial advantage for players. However, because of its repeatability and its intensity, this stroke is potentially deleterious for upper limbs, lower limbs and trunk. The trunk is a vital link in the production and transfer of energy from the lower limbs to the upper limbs; therefore, kin-ematic disorder could be a potential source of risk for trunk injury in tennis. This research studies the case of a professional tennis player who has suffered from a medical tear on the left rectus abdominis muscle after tennis serve. The goal of the study is to understand whether the injury could be explained by an inappropriate technique. For this purpose, we analyzed in three dimensions the kinematic and kinetic aspects of the serve. We also performed isokinetic tests of the player’s knees. We then compared the player to five other professional players as refer-ence. We observed a possible deficit of energy transfer because of an important anterior pelvis tilt. Some compensation made by the player during the serve could be a possible higher abdominal contraction and a larger shoulder external rotation. These partic-ularities could induce an abdominal overwork that could explain the first injury and may provoke further injuries. [less ▲]

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See detailWASP-80b has a dayside within the T-dwarf range
Triaud, Amaury H. M. J.; Gillon, Michaël ULg; Ehrenreich, David et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed ... [more ▼]

WASP-80b is a missing link in the study of exoatmospheres. It falls between the warm Neptunes and the hot Jupiters and is amenable for characterization, thanks to its host star's properties. We observed the planet through transit and during occultation with Warm Spitzer. Combining our mid-infrared transits with optical time series, we find that the planet presents a transmission spectrum indistinguishable from a horizontal line. In emission, WASP-80b is the intrinsically faintest planet whose dayside flux has been detected in both the 3.6 and 4.5 μm Spitzer channels. The depths of the occultations reveal that WASP-80b is as bright and as red as a T4 dwarf, but that its temperature is cooler. If planets go through the equivalent of an L-T transition, our results would imply that this happens at cooler temperatures than for brown dwarfs. Placing WASP-80b's dayside into a colour-magnitude diagram, it falls exactly at the junction between a blackbody model and the T-dwarf sequence; we cannot discern which of those two interpretations is the more likely. WASP-80b's flux density is as low as GJ 436b at 3.6 μm; the planet's dayside is also fainter, but bluer than HD 189733Ab's nightside (in the [3.6] and [4.5]Spitzer bands). Flux measurements on other planets with similar equilibrium temperatures are required to establish whether irradiated gas giants, such as brown dwarfs, transition between two spectral classes. An eventual detection of methane absorption in transmission would also help lift that degeneracy. We obtained a second series of high-resolution spectra during transit, using HARPS. We reanalyse the Rossiter-McLaughlin effect. The data now favour an aligned orbital solution and a stellar rotation nearly three times slower than stellar line broadening implies. A contribution to stellar line broadening, maybe macroturbulence, is likely to have been underestimated for cool stars, whose rotations have therefore been systematically overestimated. [less ▲]

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See detailRuthenium–arene catalysts bearing N-heterocyclic carbene ligands for olefin cyclopropanation and metathesis
Méret, M.; Maj, A. M.; Demonceau, Albert ULg et al

in Monatshefte für Chemie = Chemical Monthly (2015), 146(7), 1099-1105

Abstract: Ruthenium–arene complexes bearing N-heterocyclic carbene (NHC) ligands with the generic formula [RuCl2(p-cymene)(NHC)] are efficient catalyst precursors for the cyclopropanation of activated ... [more ▼]

Abstract: Ruthenium–arene complexes bearing N-heterocyclic carbene (NHC) ligands with the generic formula [RuCl2(p-cymene)(NHC)] are efficient catalyst precursors for the cyclopropanation of activated olefins with ethyl diazoacetate, and the cis/trans diastereoselectivity of the reaction markedly depends on the steric bulk of the NHC. The procedure was successfully applied to styrene, α-methylstyrene, and various other styrenic derivatives bearing electron-withdrawing or donating substituents on their aromatic rings. The reaction of unactivated internal or terminal alkenes was more sluggish, and the use of norbornene as a substrate afforded only olefin metathesis. Further investigation of the ring-opening metathesis polymerization of this strained cycloolefin in the presence of trimethylsilyldiazomethane led to high molecular weight polynorbornene whose microstructure was not significantly affected by the choice of the NHC ancillary ligand. [less ▲]

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See detailModel-based computation of total stressed blood volume from a preload reduction manoeuvre
Pironet, Antoine ULg; Desaive, Thomas ULg; Chase, J. Geoffrey et al

in Mathematical Biosciences (2015), 265(0), 28-39

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment ... [more ▼]

Total stressed blood volume is an important parameter for both doctors and engineers. From a medical point of view, it has been associated with the success or failure of fluid therapy, a primary treatment to manage acute circulatory failure. From an engineering point of view, it dictates the cardiovascular system’s behavior in changing physiological situations. Current methods to determine this parameter involve repeated phases of circulatory arrests followed by fluid administration. In this work, a more straightforward method is developed using data from a preload reduction manoeuvre. A simple six-chamber cardiovascular system model is used and its parameters are adjusted to pig experimental data. The parameter adjustment process has three steps: (1) compute nominal values for all model parameters; (2) determine the five most sensitive parameters; and (3) adjust only these five parameters. Stressed blood volume was selected by the algorithm, which emphasizes the importance of this parameter. The model was able to track experimental trends with a maximal root mean squared error of 29.2%. Computed stressed blood volume equals 486 ± 117 ml or 15.7 ± 3.6 ml/kg, which matches previous independent experiments on pigs, dogs and humans. The method proposed in this work thus provides a simple way to compute total stressed blood volume from usual hemodynamic data. [less ▲]

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See detailReinforcement Learning of Heuristic EV Fleet Charging in a Day-Ahead Electricity Market
Vandael, Stijn; Claessens, Bert; Ernst, Damien ULg et al

in IEEE Transactions on Smart Grid (2015), 6(4), 1795-1805

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand ... [more ▼]

This paper addresses the problem of defining a day-ahead consumption plan for charging a fleet of electric vehicles (EVs), and following this plan during operation. A challenge herein is the beforehand unknown charging flexibility of EVs, which depends on numerous details about each EV (e.g., plug-in times, power limitations, battery size, power curve, etc.). To cope with this challenge, EV charging is controlled during opertion by a heuristic scheme, and the resulting charging behavior of the EV fleet is learned by using batch mode reinforcement learning. Based on this learned behavior, a cost-effective day-ahead consumption plan can be defined. In simulation experiments, our approach is benchmarked against a multistage stochastic programming solution, which uses an exact model of each EVs charging flexibility. Results show that our approach is able to find a day-ahead consumption plan with comparable quality to the benchmark solution, without requiring an exact day-ahead model of each EVs charging flexibility. [less ▲]

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See detailConnections between the design tool, design attributes, and user preferences in early stage design
Häggman, Anders; Tsai, Geoff; Elsen, Catherine ULg et al

in Journal of Mechanical Design (2015), 137(7), 13

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user ... [more ▼]

Gathering user feedback on provisional design concepts early in the design process has the potential to reduce time-to-market and create more satisfying products. Among the parameters that shape user response to a product, this paper investigates how design experts use sketches, physical prototypes, and computer-aided design (CAD) to generate and represent ideas, as well as how these tools are linked to design attributes and multiple measures of design quality. Eighteen expert designers individually addressed a 2 hr design task using only sketches, foam prototypes, or CAD. It was found that prototyped designs were generated more quickly than those created using sketches or CAD. Analysis of 406 crowdsourced responses to the resulting designs showed that those created as prototypes were perceived as more novel, more aesthetically pleasing, and more comfortable to use. It was also found that designs perceived as more novel tended to fare poorly on all other measured qualities. [less ▲]

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See detailLong-term XMM-Newton investigation of two particle-accelerating colliding-wind binaries in NGC6604: HD168112 and HD167971
De Becker, Michaël ULg

in Monthly Notices of the Royal Astronomical Society (2015), 451(1), 5589-5599

The long-term (over more than one decade) X-ray emission from two massive stellar systems known to be particle accelerators is investigated using XMM-Newton. Their X-ray properties are interpreted taking ... [more ▼]

The long-term (over more than one decade) X-ray emission from two massive stellar systems known to be particle accelerators is investigated using XMM-Newton. Their X-ray properties are interpreted taking into account recent information about their multiplicity and orbital parameters. The two targets, HD168112 and HD167971 appear to be overluminous in X-rays, lending additional support to the idea that a significant contribution of the X-ray emission comes from colliding-wind regions. The variability of the X-ray flux from HD168112 is interpreted in terms of varying separation expected to follow the 1/D rule for adiabatic shocked winds. For HD167971, marginal decrease of the X-ray flux in September 2002 could tentatively be explained by a partial wind eclipse in the close pair. No long-term variability could be demonstrated despite the significant difference of separation between 2002 and 2014. This suggests the colliding-wind region in the wide orbit does not contribute a lot to the total X-ray emission, with a main contribution coming from the radiative shocked winds in the eclipsing pair. The later result provides evidence that shocks in a colliding-wind region may be efficient particle accelerators even in the absence of bright X-ray emission, suggesting particle acceleration may operate in a wide range of conditions. Finally, in hierarchical triple O-type systems, thermal X-rays do not necessarily constitute an efficient tracer to detect the wind-wind interaction in the long period orbit. [less ▲]

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See detailLa Belgique ‘officielle’ face à l’OAS (1961-1964). Cas d’une adaptation de Bruxelles à la politique du général De Gaulle
Genin, Vincent ULg

in Revue du Nord (2015), 406 (octobre-décembre 2014)(96), 917-935

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 33

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailAn XFEM/CZM implementation for massively parallel simulations of composites fracture
Vigueras, Guillermo; Sket, Federico; Samaniego, Cristobal et al

in Composite Structures (2015), 125

Because of their widely spread use in many industries, composites are the subject of many research campaigns. More particularly, the development of both accurate and flexible numerical models able to ... [more ▼]

Because of their widely spread use in many industries, composites are the subject of many research campaigns. More particularly, the development of both accurate and flexible numerical models able to capture their intrinsically multiscale modes of failure is still a challenge. The standard finite element method typically requires intensive remeshing to adequately capture the geometry of the cracks and high accuracy is thus often sacrificed in favor of scalability, and vice versa. In an effort to preserve both properties, we present here an extended finite element method (XFEM) for large scale composite fracture simulations. In this formulation, the standard FEM formulation is partially enriched by use of shifted Heaviside functions with special attention paid to the scalability of the scheme. This enrichment technique offers several benefits, since the interpolation property of the standard shape function still holds at the nodes. Those benefits include (i) no extra boundary condition for the enrichment degree of freedom, and (ii) no need for transition/blending regions; both of which contribute to maintain the scalability of the code. Two different cohesive zone models (CZM) are then adopted to capture the physics of the crack propagation mechanisms. At the intralaminar level, an extrinsic CZM embedded in the XFEM formulation is used. At the interlaminar level, an intrinsic CZM is adopted for predicting the failure. The overall framework is implemented in ALYA, a mechanics code specifically developed for large scale, massively parallel simulations of coupled multi-physics problems. The implementation of both intrinsic and extrinsic CZM models within the code is such that it conserves the extremely efficient scalability of ALYA while providing accurate physical simulations of computationally expensive phenomena. The strong scalability provided by the proposed implementation is demonstrated. The model is ultimately validated against a full experimental campaign of loading tests and X-ray tomography analyses for a chosen very large scale. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 33

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailCorporate Disclosures, Information Asymmetry and Stock-Market Liquidity in France
Sougné, Danielle ULg; Ajina, Aymen; Lakhal, Faten

in Journal of Applied Business Research (2015), Vol 31(4),

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of ... [more ▼]

This paper aims at studying the effect of corporate disclosures on information asymmetry and stock-market liquidity in France. Specifically, the purpose of this paper is to highlight the importance of information included in the annual reports on investor’s behavior. This is proxied by the information asymmetry component of the bid-ask spread and stock market liquidity. Our sample includes 196 French listed firms over a period ranging from 2004 to 2007. We opt for an explanatory study using OLS regressions to examine the nature of the relationship between information disclosed in annual reports and bid-ask spreads a proxy for information asymmetry and stock market liquidity. The results show that the extent of corporate disclosures in annual reports positively influences the liquidity of the French market and negatively affects the adverse selection component of the bid-ask spread. This effect is further confirmed by the commitment to IFRS by French-listed firms from 2005. The decomposition of the total score in the sub-indices shows that non-financial and financial information are important in trading decisions while strategic information may be attractive only for long-term positions [less ▲]

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See detailThe Geoarchaeology of Utica, Tunisia: The Paleogeography of the Mejerda Delta and Hypotheses Concerning the Location of the Ancient Harbor
Delile, Hugo; Abichou; Gadhoum, Ahmed et al

in Geoarchaeology (2015), 30(4), 291-306

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See detailSpectroscopic survey of Kepler stars. I. HERMES/Mercator observations of A- and F-type stars
Niemczura, E.; Murphy, S. J.; Smalley, B. et al

in Monthly Notices of the Royal Astronomical Society (2015), 450

The Kepler space mission provided near-continuous and high-precision photometry of about 207,000 stars, which can be used for asteroseismology. However, for successful seismic modelling it is equally ... [more ▼]

The Kepler space mission provided near-continuous and high-precision photometry of about 207,000 stars, which can be used for asteroseismology. However, for successful seismic modelling it is equally important to have accurate stellar physical parameters. Therefore, supplementary ground-based data are needed. We report the results of the analysis of high-resolution spectroscopic data of A- and F-type stars from the Kepler field, which were obtained with the HERMES spectrograph on the Mercator telescope. We determined spectral types, atmospheric parameters and chemical abundances for a sample of 117 stars. Hydrogen Balmer, Fe I, and Fe II lines were used to derive effective temperatures, surface gravities, and microturbulent velocities. We determined chemical abundances and projected rotational velocities using a spectrum synthesis technique. The atmospheric parameters obtained were compared with those from the Kepler Input Catalogue (KIC), confirming that the KIC effective temperatures are underestimated for A stars. Effective temperatures calculated by spectral energy distribution fitting are in good agreement with those determined from the spectral line analysis. The analysed sample comprises stars with approximately solar chemical abundances, as well as chemically peculiar stars of the Am, Ap, and Lambda Boo types. The distribution of the projected rotational velocity, Vsini, is typical for A and F stars and ranges from 8 to about 280 km/s, with a mean of 134 km/s. [less ▲]

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See detailCould alternative solanaceous hosts act as refuges for the tomato leafminer, Tuta absoluta?
Bawin, Thomas ULg; Dujeu, David ULg; De Backer, Lara ULg et al

in Arthropod-Plant Interactions (2015)

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous plants. The characterization of its effective ... [more ▼]

The tomato leafminer, Tuta absoluta (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous plants. The characterization of its effective host range could help to understand and prevent the dispersion behavior of the insect in the environment. In this study, the ability of T. absoluta to locate and develop on wild (Solanum nigrum, Atropa belladonna, Datura stramonium) and cultivated (Solanum tuberosum) solanaceous plant species under laboratory conditions was assessed. Dual-choice behavioral assays performed in flying tunnels (S. tuberosum versus another plant) revealed that adult distribution and female oviposition did not differ between Solanum species, which were preferred to the other tested plants. The volatile molecules released by each tested plant species provide some explanations in the observed behavioral discrimination: S. nigrum and S. tuberosum volatile profiles were similar, and were presenting quantitative and qualitative differences with the other tested Solanaceous plants. To determine whether the host plant choice was adaptive or not, we have finally conducted fitness assays, by rearing T. absoluta larvae on each plant species and have shown that Solanum species allowed higher larval survivability and lower development time (from egg to adult emergency) compared to the other plants. We conclude that Solanum species are suitable host plants for T. absoluta, but other Solanaceous plant species could be opportunistically colonized with fewer incidences. [less ▲]

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See detailMetal bioavailability and bioaccumulation in the polychaete Nereis virens (Sars): the effects of site-specific sediment characteristics
Pini, Jennifer; Richir, Jonathan ULg; Watson, Gordon

in Marine Pollution Bulletin (2015), 95(2), 565575

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis (Alitta) virens, as well as the ... [more ▼]

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis (Alitta) virens, as well as the importance of site-specific sediment characteristics in that process. Sediment, pore water and N. virens were sampled from seven sites with different pollution histories along the English Channel coast. Results showed that site-specific metal levels and sediment characteristics were important in determining the bioavailability of metals to worms. Significant correlations were found between Cu in the sediment and in the pore water and between Zn in the pore water and in N. virens. Zn from the pore water was thus more readily available from a dissolved source to N. virens than Cu. Data also showed that metal concentrations in N. virens were lower than those found in other closely related polychaetes, indicating that it may regulate tissue concentrations of Cu and Zn. [less ▲]

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See detailMultiscale structure characterization of sawdust-waste water sludge extrudates dried in a pilot-scale fixed bed
Li, Jie ULg; Plougonven, Erwan ULg; Fraikin, Laurent ULg et al

in Biomass and Bioenergy (2015), 81(0), 98-107

Abstract Convective drying of waste water sludge and sawdust-sludge mixtures in a pilot-scale fixed bed was studied. Drying was performed in a cross-flow convective dryer using 500 g of wet material ... [more ▼]

Abstract Convective drying of waste water sludge and sawdust-sludge mixtures in a pilot-scale fixed bed was studied. Drying was performed in a cross-flow convective dryer using 500 g of wet material extruded through a disk with circular dies 12 mm in diameter. The structure of the bed mainly shows volume shrinkage and crack formation during drying. Several characterization techniques were used over a wide range of scales from nm up to mm. The overall bed structure was imaged with X-ray macrotomography, at a resolution of 0.36 mm per pixel. Single extrudates were scanned with X-ray microtomography, at a resolution of 41 μm per pixel. Pore structure of the dried samples were characterized by mercury porosimetry (7.5 nm < dp < 150 μm). Results show significant structural changes on all scales with increasing amounts of sawdust: shrinkage decreases, crack formation increases, and the pores become larger. This confirms the benefits of sawdust addition for sludge drying applications. [less ▲]

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See detailAging mechanisms in amorphous phase-change materials
Raty, Jean-Yves ULg; Zhang, wei; Luckas, Jennifer et al

in Nature Communications (2015), 6(7467), 1-8

Aging is a ubiquitous phenomenon in glasses. In the case of phase-change materials, it leads to a drift in the electrical resistance, which hinders the development of ultrahigh density storage devices ... [more ▼]

Aging is a ubiquitous phenomenon in glasses. In the case of phase-change materials, it leads to a drift in the electrical resistance, which hinders the development of ultrahigh density storage devices. Here we elucidate the aging process in amorphous GeTe, a prototypical phase-change material, by advanced numerical simulations, photothermal deflection spectroscopy and impedance spectroscopy experiments. We show that aging is accompanied by a progressive change of the local chemical order towards the crystalline one. Yet, the glass evolves towards a covalent amorphous network with increasing Peierls distortion, whose structural and electronic properties drift away from those of the resonantly bonded crystal. This behaviour sets phase-change materials apart from conventional glass-forming systems, which display the same local structure and bonding in both phases [less ▲]

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See detailGalectin-3 and suppression of tumorignenicity 2 measurment in participat at the "Tor des Géants"
LE GOFF, Caroline ULg

in Final programme European College of sport Science (2015)

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See detailSuperstudio’s Dystopian Tales: Textual and Graphic Practice as Operational Method
Prina, Daniela ULg

in Writing Visual Culture (2015), 6

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See detailHigh-dose oral intake of serotonin induces valvular heart disease in rabbits.
Lancellotti, Patrizio ULg; NCHIMI LONGANG, Alain ULg; Hego, Alexandre ULg et al

in International Journal of Cardiology (2015), 197

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely ... [more ▼]

Carcinoid tumors are rare neuroendocrine malignancies, often originating from enterochromaffin cells in the gastrointestinal tract. They can secrete serotonin (5-hydroxytryptamine, 5-HT), which is largely inactivated by the liver. Carcinoid heart disease occurs when tumor cells metastasize to the liver, as the vasoactive substances produced are able to reach the systemic circulation via the hepatic vein, causing deposition of fibrous tissue on the endocardial surfaces of the heart. It is predominantly manifested by right-sided valvular heart disease (VHD). Scavenging enzymes in the pulmonary endothelium may explain why left-sided cardiac involvement is unusual. The severity of cardiac damage is correlated with the plasmatic levels of serotonin, but the lowspecificity of serotonin for cardiac damage suggests that serotonin may be necessary but not sufficient to induce cardiac lesions. Therefore, other factors combined with serotonin might be required to induce VHD. However, recent animal studies confirmed the development of carcinoid-like valvular deposits in rats after 3 months of daily subcutaneous/intraperitoneal serotonin injections to avoid the liver first-pass clearance.Whether oral administration of serotonin can also induce VHD is unknown. We hypothesized that long-term oral serotonin overload in rabbits can lead to VHD, mimicking serotonin-induced lesions of carcinoid heart disease. We demonstrate, for the first time that high dose long-term oral administration of serotonin can lead to VHD in rabbits. [less ▲]

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See detailUncertainty of climate change impact on groundwater reserves – Application to a chalk aquifer
Goderniaux, Pascal; Brouyère, Serge ULg; Wildemeersch, Samuel et al

in Journal of Hydrology (2015), 528

Recent studies have evaluated the impact of climate change on groundwater resources for different geographical and climatic contexts. However, most studies have either not estimated the uncertainty around ... [more ▼]

Recent studies have evaluated the impact of climate change on groundwater resources for different geographical and climatic contexts. However, most studies have either not estimated the uncertainty around projected impacts or have limited the analysis to the uncertainty related to climate models. In this study, the uncertainties around impact projections from several sources (climate models, natural variability of the weather, hydrological model calibration) are calculated and compared for the Geer catchment (465 km2) in Belgium. We use a surface–subsurface integrated model implemented using the finite element code HydroGeoSphere, coupled with climate change scenarios (2010–2085) and the UCODE_2005 inverse model, to assess the uncertainty related to the calibration of the hydrological model. This integrated model provides a more realistic representation of the water exchanges between surface and subsurface domains and constrains more the calibration with the use of both surface and subsurface observed data. Sensitivity and uncertainty analyses were performed on predictions. The linear uncertainty analysis is approximate for this nonlinear system, but it provides some measure of uncertainty for computationally demanding models. Results show that, for the Geer catchment, the most important uncertainty is related to calibration of the hydrological model. The total uncertainty associated with the prediction of groundwater levels remains large. By the end of the century, however, the uncertainty becomes smaller than the predicted decline in groundwater levels. [less ▲]

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See detailLandscape Control on the Spatial and Temporal Variability of Chromophoric Dissolved Organic Matter and Dissolved Organic Carbon in Large African Rivers
Lambert, Thibault ULg; Darchambeau, François ULg; Bouillon, Steven et al

in Ecosystems (2015)

The characteristics of colored dissolved organic matter (CDOM) as well as the concentrations and stable isotope composition (d 13 C) of dissolved organic carbon (DOC) were characterized in several large ... [more ▼]

The characteristics of colored dissolved organic matter (CDOM) as well as the concentrations and stable isotope composition (d 13 C) of dissolved organic carbon (DOC) were characterized in several large rivers of Africa including the Congo, Niger, Zambezi, and Ogooué basins. We compared the spatial and temporal patterns of dissolved organic matter (DOM) quantity and quality along with various environmental gradients, including hydrology, river size, catchment vegetation, and connectivity to land. The optical proxies used include the absorption coefficient at 350 nm, the specific ultraviolet absorbance, and the spectral slope ratio (S R = 275–295-nm slope divided by 350–400-nm slope). Our results show that land cover plays a primary role in controlling both DOC concentration and optical properties of DOM in tropical freshwaters. A higher cover of dense forest in the catchment leads to a higher quantity of highly aromatic DOM in the river network, whereas an increasing savannah cover results in lower DOC concentrations and less absorptive DOM. In addition to land cover, the watershed morphology (expressed by the average slope) exerts a strong control on DOC and CDOM in tropical rivers. Our results also show that the percentage of C3 and C4 vegetation cover is not an accurate predictor for DOM and CDOM quality in rivers due to the importance of the spatial distribution of land cover within the drainage network. The comparison of our results with previously published CDOM data in temperate and high-latitude rivers highlights that DOM in tropical freshwa-ters is generally more aromatic, and shows a higher capacity for absorbing sunlight irradiance. [less ▲]

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See detailLa limitation du cumul de mandats par les députés wallons
Grandjean, Geoffrey ULg

in Courrier Hebdomadaire du CRISP (2015), 2255-2256

En moyenne, les représentants politiques belges cumulent entre cinq et huit mandats (dont la moitié sont rémunérés). Cette pratique contribue au développement des sentiments de méfiance que nourrit une ... [more ▼]

En moyenne, les représentants politiques belges cumulent entre cinq et huit mandats (dont la moitié sont rémunérés). Cette pratique contribue au développement des sentiments de méfiance que nourrit une partie de la population à l’égard des élus et des institutions. Dans un souci de bonne gouvernance, de nombreux citoyens et acteurs politiques appellent dès lors à une limitation des possibilités légales de cumul de mandats. La traduction récente la plus emblématique de cette préoccupation éthique est le décret décumul adopté en Région wallonne en 2010. Désormais, un député wallon n’a plus le droit de cumuler son mandat avec une fonction de bourgmestre, d’échevin ou de président d’un conseil de l’action sociale. Un quart des membres de chaque groupe politique représenté au Parlement wallon est cependant autorisé à cumuler. Les députés qui bénéficient de cette exception sont désignés sur la base de leur taux de pénétration électorale. Ce mécanisme est le fruit d’un accord politique conclu entre les partenaires du gouvernement régional (PS, Écolo, CDH). Son adoption a fait l’objet de débats nombreux et souvent tendus entre les partis politiques, en ce compris au sein de la majorité. Ce Courrier hebdomadaire retrace l’ensemble du processus législatif à la base du décret décumul. Il replace l’initiative dans son contexte et analyse le jeu des différents acteurs, en réservant une attention particulière aux divers arguments politiques, techniques et surtout juridiques qui ont été mobilisés. G. Grandjean se penche également sur les effets que le décret a eus pour les députés élus lors du scrutin régional wallon du 25 mai 2014. Enfin, il s’interroge sur l’avenir du décret décumul, que certains voudraient réformer, voire supprimer. [less ▲]

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See detailMAVEN IUVS observations of the aftermath of the Comet Siding Spring meteor shower on Mars
Schneider, Nick; Deighan, Justin; Stewart, Ian et al

in Geophysical Research Letters (2015)

We report the detection of intense emission from magnesium and iron in Mars' atmosphere caused by a meteor shower following Comet Siding Spring's close encounter with Mars. The observations were made with ... [more ▼]

We report the detection of intense emission from magnesium and iron in Mars' atmosphere caused by a meteor shower following Comet Siding Spring's close encounter with Mars. The observations were made with the Imaging Ultraviolet Spectrograph, a remote sensing instrument on the Mars Atmosphere and Volatile EvolutioN spacecraft orbiting Mars. Ionized magnesium caused the brightest emission from the planet's atmosphere for many hours, resulting from resonant scattering of solar ultraviolet light. Modeling suggests a substantial fluence of low-density dust particles 1–100 µm in size, with the large amount and small size contrary to predictions. The event created a temporary planet-wide ionospheric layer below Mars' main dayside ionosphere. The dramatic meteor shower response at Mars is starkly different from the case at Earth, where a steady state metal layer is always observable but perturbations caused by even the strongest meteor showers are challenging to detect. [less ▲]

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See detailImpact of Different Thermal Comfort Models on Zero Energy Residential Buildings in Hot Climate
Attia, Shady ULg; Carlucci, Salvatore

in Energy & Buildings (2015)

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates ... [more ▼]

The selection of a thermal comfort model for establishing indoor optimal hygrothermal conditions during the hot period has a major impact on energy consumption of Net Zero Energy Buildings in hot climates. The objective of this paper is to compare the influence of using different thermal comfort models for zero energy buildings in hot climates. The paper compares the impact of applying Fanger’s model, Givoni’s model, the ASHRAE 55 adaptive comfort model and the EN 15251 adaptive comfort model on energy consumption and comfort performance. Using both the building performance simulation tools ZEBO and EnergyPlus for energy simulation, an existing prototype of a residential apartment module is used to evaluate energy performance and thermal comfort in two parametric series. The first one is the result of coupling natural ventilation and mechanical cooling and the second one is guided coupling natural ventilation, mechanical cooling and ceiling fans. This study shows that the percentage of energy consumption difference meeting the comfort criteria according to ISO 7730 in comparison to EN 15251, ASHRAE 55 or Givoni’s model varied up to 16%, 21% and 24.7% respectively for the presented case study. More energy savings can be expected for buildings in hot climates with greater cooling demands. [less ▲]

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (2015)

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailA semiquantitative framework for gene regulatory networks: increasing the time and quantitative resolution of Boolean networks
Kerkhofs, Johan ULg; Geris, Liesbet ULg

in PLoS ONE (2015), 10(6), 0130033

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic ... [more ▼]

Boolean models have been instrumental in predicting general features of gene networks and more recently also as explorative tools in specific biological applications. In this study we introduce a basic quantitative and a limited time resolution to a discrete (Boolean) framework. Quantitative resolution is improved through the employ of normalized variables in unison with an additive approach. Increased time resolution stems from the introduction of two distinct priority classes. Through the implementation of a previously published chondrocyte network and T helper cell network, we show that this addition of quantitative and time resolution broadens the scope of biological behaviour that can be captured by the models. Specifically, the quantitative resolution readily allows models to discern qualitative differences in dosage response to growth factors. The limited time resolution, in turn, can influence the reachability of attractors, delineating the likely long term system behaviour. Importantly, the information required for implementation of these features, such as the nature of an interaction, is typically obtainable from the literature. Nonetheless, a trade-off is always present between additional computational cost of this approach and the likelihood of extending the model’s scope. Indeed, in some cases the inclusion of these features does not yield additional insight. This framework, incorporating increased and readily available time and semi-quantitative resolution, can help in substantiating the litmus test of dynamics for gene networks, firstly by excluding unlikely dynamics and secondly by refining falsifiable predictions on qualitative behaviour. [less ▲]

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See detailFluorinated alcohols as activators for the solvent-free chemical fixation of carbon dioxide onto epoxides
Gennen, Sandro ULg; Alves, Margot ULg; Méreau, Raphaël et al

in ChemSusChem (2015), 8(11), 1845-1849

The addition of fluorinated alcohols to onium salts provides highly efficient organocatalysts for the chemical fixation of CO2 onto epoxides under mild experimental conditions. The combination of online ... [more ▼]

The addition of fluorinated alcohols to onium salts provides highly efficient organocatalysts for the chemical fixation of CO2 onto epoxides under mild experimental conditions. The combination of online kinetic studies, NMR titrations and DFT calculations allows understanding this synergistic effect that provides an active organocatalyst for CO2/epoxides coupling. [less ▲]

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See detailA new design of organic radical batteries (ORBs): carbon nanotube buckypaper electrode functionalized by electrografting
Aqil, Abdelhafid ULg; Vlad, Alexandru; Piedboeuf, Marie-Laure ULg et al

in Chemical Communications (2015), 51(45), 9301-9304

A novel hybridmaterial displaying a fast and reversible charge storage capability is prepared by electrografting of an alkoxyamine-bearing acrylate onto a carbon nanotube buckypaper, followed by the quan ... [more ▼]

A novel hybridmaterial displaying a fast and reversible charge storage capability is prepared by electrografting of an alkoxyamine-bearing acrylate onto a carbon nanotube buckypaper, followed by the quan- titative generation of an electroactive polynitroxide. [less ▲]

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See detailGlobal parasite and Rattus rodent invasions: The consequences for rodent-borne diseases
Morand, Serge; Bordes, Frédéric; Chen, Hsuan-Wien et al

in Integrative Zoology (2015)

We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of ... [more ▼]

We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of rodent-borne diseases. Parasites play an important role in the invasion processes and successes of their hosts through multiple biological mechanisms such as "parasite release", "immunocompetence advantage", “biotic resistance” and "novel weapon". Parasites may also greatly increase the impact of invasions by spillover of parasites and other pathogens, introduced with invasive hosts, into new hosts potentially leading to novel emerging diseases. Another potential impact is the ability of the invader to amplify local parasites by spill-back. In both cases, local fauna and humans may be exposed to new health risks, which may decrease biodiversity and may potentially cause increases in human morbidity and mortality. Here we review the current knowledge on these processes and propose some research priorities. [less ▲]

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See detailNovel nanosized water soluble fluorescent micelles with embedded perylene diimide fluorophores for potential biomedical applications: Cell permeability, localization and cytotoxicity
Bryaskova, Rayna; Georgiev, Nikolai I.; Dimov, Stefan M. et al

in Materials Science & Engineering : C (2015), 51

Novel biocompatiblewater-soluble fluorescent micelleswithembedded perylene diimides (PDI) for intracellular applications have been prepared by self assembling of amphiphilic poly(vinyl alcohol)-b-poly ... [more ▼]

Novel biocompatiblewater-soluble fluorescent micelleswithembedded perylene diimides (PDI) for intracellular applications have been prepared by self assembling of amphiphilic poly(vinyl alcohol)-b-poly(acrylonitrile) (PVA-b-PAN) copolymers in the presence of synthesized fluorophores. Amphiphilic PVA-b-PAN copolymers were obtained by selective hydrolysis of well-defined poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) copolymer. The preparation of the novel fluorescence micelles consisting of PVA hydrophilic shell and PAN hy- drophobic core with incorporated PDI fluorophores has been confirmed by DLS and TEManalysis. The cytotoxic- ity of the water-soluble fluorophores and their internalization into living cells depending on the micellar concentration have been tested. Itwas shown that they could successfully enter in living cellswithout destroying their morphology. The results obtained indicate that the novel water-soluble fluorescent micelles with embed- ded PDI fluorophores would be suitable for potential intracellular biomedical applications. [less ▲]

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See detailEffects of Holothuroid Ichtyotoxic Saponins on the Gills of Free-Living Fishes and Symbiotic Pearlfishes
Eeckhaut, Igor; Caulier, Guillaume; Brasseur, Lola et al

in The Biological Bulletin (2015), 228(3), 253-265

Several carapid fishes, known as pearlfishes, are endosymbiotic in holothuroids and asteroids. These echinoderms contain a strong concentration of saponins that are efficient membranolytic repellents to ... [more ▼]

Several carapid fishes, known as pearlfishes, are endosymbiotic in holothuroids and asteroids. These echinoderms contain a strong concentration of saponins that are efficient membranolytic repellents to predators. We compared the effects of exposure to saponins from the sea cucumber body wall and from the Cuvierian tubules on the behavior and gill ultrastructure of pearlfishes and free-living fishes. Saponins were extracted from the body wall of two holothuroids, the Mediterranean Holothuria forskali and the tropical Bohadschia atra, and from the water surrounding the Cuvierian tubules of B. atra. Five species of carapids that live in symbiosis with holothuroids and seven species of free-living fishes were exposed to these extracts. The free-living fishes exhibited a stress response and died about 45 times faster than pearlfishes when exposed to the same quantity of saponins. Cuvierian tubules and saponins extracted from the body wall were lethal to the free-living fishes, whereas the carapids were much less sensitive. The carapids did not exhibit a stress response. The high toxicity shown by Cuvierian tubules was not explained by the nature of the saponins that were identified by mass spectrometry, but it is likely due to the higher concentration of saponins in the tubules. Histology and scanning and transmission electron microscopy of the gills of the free-living fishes and pearlfishes showed that saponins act at the level of the secondary lamellae where they induce the detachment of the epithelia, create edema at the level of the epithelia, and induce pores in the epithelial cells that lead to their destruction and the invasion of inner cells (pillar cells and red blood cells). This sequence of events happens 5 min after saponin exposure in free-living fishes and after 1 h in carapids. [less ▲]

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See detailThe physics of badminton
Cohen, Caroline; Darbois-Texier, Baptiste ULg; Quéré, David et al

in New Journal of Physics (2015), 17

The conical shape of a shuttlecock allows it to flip on impact. As a light and extended particle, it flies with a pure drag trajectory.We first study the flip phenomenon and the dynamics of the flight and ... [more ▼]

The conical shape of a shuttlecock allows it to flip on impact. As a light and extended particle, it flies with a pure drag trajectory.We first study the flip phenomenon and the dynamics of the flight and then discuss the implications on the game. Lastly, a possible classification of different shots is proposed. [less ▲]

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See detailThe nonlinear piezoelectric tuned vibration absorber
Soltani, Payam ULg; Kerschen, Gaëtan ULg

in Smart Materials and Structures (2015), 24(07), 075015

This paper proposes a piezoelectric vibration absorber, termed the nonlinear piezoelectric tuned vibration absorber (NPTVA), for the mitigation of nonlinear resonances of mechanical systems. The new ... [more ▼]

This paper proposes a piezoelectric vibration absorber, termed the nonlinear piezoelectric tuned vibration absorber (NPTVA), for the mitigation of nonlinear resonances of mechanical systems. The new feature of the NPTVA is that its nonlinear restoring force is designed according to a principle of similarity, i.e., the NPTVA should be an electrical analog of the nonlinear host system. Analytical formulas for the NPTVA parameters are derived using the homotopy perturbation method. Doing so, a nonlinear generalization of Den Hartog’s equal-peak tuning rule is developed for piezoelectric vibration absorbers. [less ▲]

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See detailPharmacokinetics and clinical evaluation of the alogliptin plus pioglitazone combination for type 2 diabetes.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2015), 11(6), 1005-20

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose ... [more ▼]

INTRODUCTION: Type 2 diabetes is a complex disease with multiple defects, which generally requires a combination of several pharmacological approaches to reach glucose control targets. A unique fixed-dose combination combines a thiazolidinedione (pioglitazone) and a dipeptidyl peptidase-4 inhibitor (alogliptin). Area covered: An extensive literature search was performed to analyze the pharmacokinetics of pioglitazone and alogliptin when used separately and in combination as well as to summarize clinical and toxicological considerations about the combined therapy. Expert opinion: Pioglitazone, a potent insulin sensitizer, and alogliptin, an incretin-based agent that potentiates post-meal insulin secretion and reduces glucagon secretion, have complementary mechanisms of action. The clinical efficacy of a combined therapy is superior to any single therapy in patients treated with diet or with metformin (with or without sulphonylurea). These two drugs can be administered once daily, with or without a meal. No clinically relevant pharmacokinetic interactions between the two agents have been described and the fixed-dose combination has shown bioequivalence with alogliptin and pioglitazone given separately. Combining alogliptin with pioglitazone does not alter the safety profile of each compound. Weight gain observed with pioglitazone may be limited with the addition of alogliptin. The concern of an increased risk of heart failure remains to be better investigated. [less ▲]

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See detailL’indication comme concept. La logique des « groupes althussériens » (1965-1968)
Mancuso, Eva ULg

in Cahiers du GRM (2015), VII

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See detailPanorama des incitants fiscaux destinés à stimuler l’investissement privé dans le secteur cinématographique
Vandenbulke, Antoine ULg

in Agefi Luxembourg (2015)

The film industry in Europe is largely funded through States support mechanisms. Among the many instruments set up by the various national laws, particular attention should be given to tax incentives ... [more ▼]

The film industry in Europe is largely funded through States support mechanisms. Among the many instruments set up by the various national laws, particular attention should be given to tax incentives aimed to stimulate private capital investments in this sector particularly risky. This short paper aims to outline the main features of tax breaks for the private financing of an audiovisual work in three States in particular: France, Belgium and Luxembourg. [less ▲]

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See detailFrom the Guiding Principles on Internal Displacement to the Nansen Initiative: What the Governance of Environmental Migration Can Learn from the Governance of Internal Displacement
Gemenne, François ULg; Brücker, Pauline

in International Journal of Refugee Law (2015), 27(2), 245-263

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the ... [more ▼]

Environmental migration is often presented as one of the gravest consequences of environmental disruptions – climate change in particular, and is already a reality in many parts of the world. Yet the protection of these migrants is not adequately addressed in the international normative frameworks on migration. As a result, a growing number of scholars and advocacy groups have sought to create a special convention and/or an ad hoc status for these migrants, while others have contended that such a legal status is not the answer. As a result, the protection of environmental migrants is currently the subject of vigorous debates amongst scholars and policy-makers, and no clear solution is yet in sight. Research however has little considered the debates that surrounded the protection of those displaced within their countries (IDPs) in the 1990s. Both phenomena have sometimes overlapped, especially as environmental displacement is often internal. Yet, the debate on IDPs has had some significant success, in particular, the adoption of the Guiding Principles on Internal Displacement in 1998, and the signature of the Organization for African Unity’s Kampala Convention in 2009. This article argues that important lessons can be drawn from the protection of IDPs in order to inform the current debates on the protection of environmental migrants, as the political contexts and policy challenges associated with both crises of the migration regime are often similar. The article identifies such lessons and assesses the opportunities and caveats of applying a similar approach of soft law to environmental migration – and what would be needed to achieve it. [less ▲]

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See detailThe Herschel view of the nebula around the luminous blue variable star AG Carinae
Vamvatira-Nakou, Chloi ULg; Hutsemekers, Damien ULg; Royer, P. et al

in Astronomy and Astrophysics (2015), 578

Far-infrared Herschel PACS imaging and spectroscopic observations of the nebula around the luminous blue variable (LBV) star AG Car have been obtained along with optical imaging in the Halpha+[NII] filter ... [more ▼]

Far-infrared Herschel PACS imaging and spectroscopic observations of the nebula around the luminous blue variable (LBV) star AG Car have been obtained along with optical imaging in the Halpha+[NII] filter. In the infrared light, the nebula appears as a clumpy ring shell that extends up to 1.2 pc with an inner radius of 0.4 pc. It coincides with the Halpha nebula, but extends further out. Dust modeling of the nebula was performed and indicates the presence of large grains. The dust mass is estimated to be ~ 0.2 Msun. The infrared spectrum of the nebula consists of forbidden emission lines over a dust continuum. Apart from ionized gas, these lines also indicate the existence of neutral gas in a photodissociation region that surrounds the ionized region. The abundance ratios point towards enrichment by processed material. The total mass of the nebula ejected from the central star amounts to ~ 15 Msun, assuming a dust-to-gas ratio typical of LBVs. The abundances and the mass-loss rate were used to constrain the evolutionary path of the central star and the epoch at which the nebula was ejected, with the help of available evolutionary models. This suggests an ejection during a cool LBV phase for a star of ~ 55 Msun with little rotation. [less ▲]

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See detailFor a Critical Iconology : the Meaning, Dynamics and Effectiveness of Images
Hagelstein, Maud ULg

in Critique d'Art : Actualité Francophone et Internationale de la Littérature Critique sur l'Art Contemporain = The International Review of Contemporary Art Criticism (2015)

The present-day theory of image comes in the wake of iconology, by virtue of the explicit re-use of several problematic themes which are central to this method, and permit its critical redevelopment : 1 ... [more ▼]

The present-day theory of image comes in the wake of iconology, by virtue of the explicit re-use of several problematic themes which are central to this method, and permit its critical redevelopment : 1. Reflection about iconic representation, about its relation to language and its specific logic; 2. The investigation into the dynamics of the image (circulation, persistence and development); 3. The study of the effectiveness of images and the production of many different kinds ok knowledge under the effect of editing operations. [less ▲]

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See detailGroupes délinquants juvéniles, quelle méthode pour une recherche « ethno-criminologique » ? La loi des 4 C
Witvrouw, Line ULg; Glowacz, Fabienne ULg

in Revue Internationale de Criminologie et de Police Technique et Scientifique [= RICPTS] (2015), LXVIII(Avril-Juin), 196-209

La criminologie nous amène à travailler avec des populations difficiles d’accès et requiert une démarche méthodologique structurée et prenant en compte les caractéristiques du milieu de rencontre. A ... [more ▼]

La criminologie nous amène à travailler avec des populations difficiles d’accès et requiert une démarche méthodologique structurée et prenant en compte les caractéristiques du milieu de rencontre. A partir de notre recherche portant sur les groupes de jeunes délinquants ou déviants, une spécificité est apparue dès le début des démarches empiriques. En effet, une notion d’exclusivité est entendue entre chaque membre du groupe, rendant l’accès à l’information difficile tant les frontières de ce groupe vis-à-vis de l’extérieur sont imperméables. Le chercheur se trouve alors confronté à différents obstacles: la difficulté de prise de contacts avec les groupes, la difficulté d’intégration du chercheur au sein de ceux-ci et la difficulté de récolte de données suffisantes pour la recherche. Au vu des constats de terrain, nous avons développé une méthodologie spécifique inspirée de modèles ethnologiques. En prenant en compte les jeunes en tant qu’experts de leur vécu et les intervenants médiateurs d’inclusion sur un terrain, ce processus méthodologique relève d’une co-construction de trois pôles et partenaires et s’apparente à une approche ethno-criminologique. Ce processus par étapes se décline en séquences temporelles successives. Tout d’abord, le positionnement du chercheur comme non-détenteur du savoir, la triangulation de la relation, l’acceptation de la temporalité de la démarche et de l’instrumentalisation de la relation sont autant d’éléments constituant l’étape préalable de ce processus méthodologique. Les étapes suivantes se construisent sur la base de l’évolution du lien entre le chercheur et les jeunes. La loi des 4 C réunit ces étapes, la relation évoluant de la confiance, à la confidence, ensuite à la communication pour aboutir à la coopération [less ▲]

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See detailThe Authority of Strasbourg Jurisprudence from the Perspective of the International Criminal Court
Deprez, Christophe ULg

in Journal Européen des Droits de l'Homme = European Journal of Human Rights (2015), 3

Although the case law of the European Court of Human Rights (Eur. Ct. H.R.) exerts a critical influence on the development of the practice of the International Criminal Court (ICC), it remains unclear ... [more ▼]

Although the case law of the European Court of Human Rights (Eur. Ct. H.R.) exerts a critical influence on the development of the practice of the International Criminal Court (ICC), it remains unclear what the exact authority of such external jurisprudence is vis-à-vis the international criminal judge. This article addresses the question whether ICC judges have used Strasbourg jurisprudence in a consistent manner, in particular as regards the authority which they decided to vest the latter with. It demonstrates that the Court’s chambers have relied on European human rights practice, alternatively, as a mere source of inspiration, as binding interpretation, as a corpus having ambivalent authority, or as a source whose value it simply left unspecified. It therefore concludes that the ICC has been mostly inconsistent regarding the authority of the case law of the Eur. Ct. H.R. in the context of international criminal proceedings. Such inconsistency, it is argued, amounts to a discretionary use of Strasbourg jurisprudence that further reinforces the ICC’s paradoxical position as the ultimate authority for defining the boundaries of its own human rights constraint. [less ▲]

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See detailExtended end-plate to concrete- filled rectangular column joint using long bolts
Hoang, Van Long ULg; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

in Journal of Constructional Steel Research (2015), 113

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See detailLe dosage du cobalt dans le sang par ICP-MS : application aux patients porteurs de prothèses de hanche en métal
MISTRETTA, Virginie ULg; Charlier, Corinne ULg

in Toxicologie Analytique & Clinique (2015), 27(2), 91-98

Objectif Les patients porteurs de prothèse de hanche à couple métal-métal (PHM) présentent un taux de cobalt circulant supérieur à celui de la population générale. Chez ces patients, le dosage du cobalt ... [more ▼]

Objectif Les patients porteurs de prothèse de hanche à couple métal-métal (PHM) présentent un taux de cobalt circulant supérieur à celui de la population générale. Chez ces patients, le dosage du cobalt permet d’apprécier le risque toxique éventuel de l’implant et peut servir d’indicateur de révision ou de remplacement de cette prothèse. A cette fin, une méthode de dosage a été validée et appliquée à des patients porteurs de PHM. Méthode Le dosage du cobalt est réalisé sur 500 μL de sang total, après dilution dix fois dans une solution aqueuse acide et après ajout de 100 μL d’une solution de standard interne titrée à 500 μg/L de germanium. L’échantillon est ensuite analysé par un spectromètre de masse avec source d’ionisation par plasma induit haute fréquence (ICP-MS). La méthode décrite a été validée par l’approche de l’erreur totale au moyen du logiciel e•noval (Arlenda®). Résultats La méthode de dosage a été validée avec succès. Elle est linéaire de 0,5 à 50 μg/L. L’inexactitude et l’imprécision intra- et inter-essais sont inférieures à 5 % et 8 %, respectivement. L’incertitude de mesure est inférieure à 17 %. La concentration sanguine moyenne de cobalt estimée sur une période de 1 an à partir de 107 prélèvements de patients porteurs de PHM est de 2,61 μg/L (nombre de patients : 98 ; âge moyen : 60 ans ; ratio hommes/femmes : 38/60). Ce résultat est inférieur au seuil recommandé dans ces populations, fixé à 7 μg/L de cobalt sanguin. Conclusion La méthode analytique présentée permet de doser le cobalt sanguin, notamment chez les patients porteurs de PHM. Ce dosage est recommandé pour le suivi de ces patients, en association avec un examen clinique et radiologique. [less ▲]

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See detailPrevenção quaternária: primeiro não causar dano - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-3

A prevenção clínica, sob a influência da saúde pública, foi organizada de forma cronológica, desde meados do século XX. No entanto, uma mudança de paradigma de uma ordem cronológica para um padrão ... [more ▼]

A prevenção clínica, sob a influência da saúde pública, foi organizada de forma cronológica, desde meados do século XX. No entanto, uma mudança de paradigma de uma ordem cronológica para um padrão construtivista fundamentado em uma relação preventiva de atendimento, oferece novas,reflexões à prática dos médicos. Essa mudança de paradigma traz à tona o conceito de prevenção quaternária, um olhar crítico sobre as atividades médicas, com ênfase na necessidade de não causar danos. A prevenção quaternária aborda a questão principal do que se constitui como ‘muita’ ou ‘pouca’ medicina. Ela é a quarta forma de prevenção de doenças, e também a quarta etapa de ação dos médicos de família [less ▲]

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See detailLa remise en question du droit international public. La charge critique du juriste Albéric Rolin (1918-1920)
Genin, Vincent ULg

in Bulletin d'Information du Centre Liégeois d'Histoire et d'Archéologie Militaires (2015), 138

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See detailChangement climatique et familles politiques en Europe. Entre soutien et résistance aux politiques climatiques
Moelher, Karin; Piet, Grégory ULg; Zaccai, Edwin

in Courrier Hebdomadaire du CRISP (2015), 2257

Le changement climatique constitue une thématique politique relativement récente dans les agendas politiques et électoraux. Souvent, dans le grand public, la question climatique est perçue à travers la ... [more ▼]

Le changement climatique constitue une thématique politique relativement récente dans les agendas politiques et électoraux. Souvent, dans le grand public, la question climatique est perçue à travers la médiatisation des grands sommets des Nations Unies consacrés à cette problématique (Rio de Janeiro en 1992, Kyoto en 1997, Copenhague en 2009, Paris en 2015, etc.). Mais les positions que défendent les différents pays lors de ces réunions ont bien entendu été préalablement construites, entre autres, sur les scènes nationales. Les partis politiques sont à la fois les reflets des opinions publiques et les initiateurs des régulières redéfinitions des orientations politiques qui entourent la thématique du changement climatique. Ils filtrent également les demandes politiques de la société civile qui paraissent compatibles avec leur programme et leur faisabilité, et les transforment. Aux États-Unis, la polarisation politique autour de la question du changement climatique est aisément détectable . Le Republican Party se montre fortement critique, non seulement à l’égard des politiques climatiques discutées dans les cénacles de l’ONU, mais aussi, pour une part de ce courant, quant à l’existence du phénomène du changement climatique d’origine humaine. Ce type de position est particulièrement présent au sein du Tea Party. À l’inverse, le Democratic Party se montre nettement plus favorable à des objectifs climatiques, de même que, à l’instar du président Barack Obama ou du vice-président Al Gore précédemment, il reconnaît sans ambiguïté la réalité de ce phénomène physique, l’estime inquiétant et devant motiver l’action. Qu’en est-il en Europe ? L’opinion publique s’y déclare majoritairement convaincue de la réalité de changements climatiques d’origine anthropique et la trouve préoccupante, même s’il existe une part significative de la population qui en doute. Ce scepticisme se traduit-il toutefois dans les programmes électoraux de certains partis politiques, à l’instar de ce que l’on constate aux États-Unis ? Telle a été la question à la base du présent Courrier hebdomadaire. Annonçons cependant d’emblée que ce que nous désignerons ici par « climato-scepticisme », au sens strict de mise en doute du changement climatique d’origine humaine, n’est qu’un aspect assez partiel de cette étude. Nos résultats révèlent en effet que cette position climato-sceptique est extrêmement minoritaire parmi les formations politiques d’Europe. [less ▲]

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See detailTriiodothyronine-predominant Graves’ disease in childhood: detection and therapeutic implications
HARVENGT, Julie ULg; boizeau, priscilla; chevenne, didier et al

in European Journal of Endocrinology (2015), 172(6), 715-723

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See detailAlthusser : une nouvelle pratique de la philosophie entre politique et idéologie. Conversation avec Étienne Balibar et Yves Duroux (Partie I)
Balibar, Etienne; Duroux, Yves; Bruschi, Fabio et al

in Cahiers du GRM (2015), VII

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See detailLa Belgique, un pays ‘neutre’ ou un ‘petit pays’ ? La controverse autour du maintien de la neutralité imposée de la Belgique (1914-1919)
Genin, Vincent ULg

in Bulletin d'Information du Centre Liégeois d'Histoire et d'Archéologie Militaires (2015), 138

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See detailExperimental investigation of a reversible heat pump / organic Rankine cycle unit designed to be coupled with a passive house (Net Zero Energy Building)
Dumont, Olivier ULg; Quoilin, Sylvain ULg; Lemort, Vincent ULg

in International Journal of Refrigeration (2015), 54

This paper presents an innovative reversible Heat Pump/Organic Rankine Cycle (HP/ORC) experimental unit designed to be coupled to a Net Zero Energy Building (connected to a 120 m2 thermal solar roof and a ... [more ▼]

This paper presents an innovative reversible Heat Pump/Organic Rankine Cycle (HP/ORC) experimental unit designed to be coupled to a Net Zero Energy Building (connected to a 120 m2 thermal solar roof and a ground heat exchanger). The system can operate in three different modes: an ORC mode to produce electricity when a large amount of heat is collected by the solar roof, a direct heating mode using exclusively the solar roof, and a HP mode for space heating during cold weather conditions. This paper describes a comprehensive experimental campaign carried out on a prototype unit using a modified HVAC scroll compressor (4 kWe). From the results, the technical feasibility of the system is demonstrated. A cycle efficiency of 4.2% is achieved in ORC mode (with condensation and evaporation temperature respectively of 25 C and 88 C) and a COP of 3.1 is obtained in HP mode (with condensation and evaporation temperature respectively of 61 C and 21 C). [less ▲]

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See detailDefensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
Suarez-Carmona, Meggy ULg; Hubert, Pascale ULg; Delvenne, Philippe ULg et al

in Cytokine & Growth Factor Reviews (2015), 26

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See detailLes prix de traduction fabriquent-ils une image régulatrice du traducteur ?
Mogollon Zapata, Juan Manuel ULg; Valéry, Plouhinec

in Convergences francophones (2015), 2

Les prix de traduction participent à la fois aux luttes pour la détention d’un capital de consécration et à la construction de l’image publique du traducteur. Ils sont une excellente entrée pour mesurer ... [more ▼]

Les prix de traduction participent à la fois aux luttes pour la détention d’un capital de consécration et à la construction de l’image publique du traducteur. Ils sont une excellente entrée pour mesurer les discours qui circulent dans l’espace du livre sur le traducteur et sa pratique. Comment ces prix construisent-ils une image légitimante du traducteur ? Quels critères guident le choix des jurys et quels dispositifs discursifs les justifient ? Quelles retombées pour les traducteurs et l’image de la traduction en général ? À travers l’analyse de nombreux exemples, cet article cherche à établir la manière dont les prix de traduction produisent un discours légitimant sur la figure du traducteur qui contribue à la fabrication de son image. [less ▲]

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See detailInvestigation of Demagnetization in HTS Stacked Tapes Implemented in Electric Machines as a Result of Crossed Magnetic Field
Baghdadi, M.; Ruiz, H. S.; Fagnard, Jean-François ULg et al

in IEEE Transactions on Applied Superconductivity (2015), 25(3), 6602404

This paper investigates the practical effectiveness of employing superconducting stacked tapes to superconducting electric machinery. The use of superconducting bulks in various practical applications has ... [more ▼]

This paper investigates the practical effectiveness of employing superconducting stacked tapes to superconducting electric machinery. The use of superconducting bulks in various practical applications has been addressed extensively in the literature. However, in practice, dramatic decrease in magnetization would occur on superconducting bulks due to the crossed field effect. In our study, we employed the superconducting stacked tapes in a synchronous superconducting motor, which was designed and fabricated in our laboratory, aiming to lessen demagnetization due to crossed field effect in comparison with superconducting bulks. Applying the transverse AC field, the effects of frequency, amplitude, and number of cycles of the transverse magnetic field are discussed. Furthermore, a stack of 16 layers of superconducting tapes is modelled and the consequences of applying the crossed magnetic field on the sample are evaluated. The confrontation between experiments and simulation allows us to thoroughly understand the crossed field effects on stacked tapes. At the end, a preventive treatment, based on the shielding characteristic of superconductor and materials with high permeability, i.e. $mu$-metal and metalic glass, is suggested. On the other hand, the shielding feature of aforementioned materials will hinder the penetration of magnetic field and, consequently, reduction of the demagnetization will be attained. [less ▲]

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See detailMultiple analyses of microbial communities applied to the gut of the wood-feeding termite Reticulitermes flavipes fed on artificial diets
Tarayre, Cédric ULg; Bauwens, Julien ULg; Mattéotti, Christel et al

in Symbiosis (2015)

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on ... [more ▼]

The purpose of this work was the observation of the differences between the microbial communities living in the gut of the termite Reticulitermes flavipes fed on different diets. The termites were fed on poplar wood (original diet) and artificial diets consisting of crystalline cellulose (with and without lignin), α-cellulose (with and without lignin) and xylan. The termites were then dissected and the protist communities were analyzed through microscopy, leading to the conclusion that protist species are strongly influenced by diets. BIOLOG ECO Microplates® were used to assess the metabolic properties of the different types of consortia, highlighting strong differences on the basis of principal component analysis and calculation of similarity rates. The microorganisms were cultivated in liquid media corresponding to the artificial diets before being characterized through a metagenetic analysis of gut microbiota (16S ribosomal DNA). This analysis identified several phyla: Acidobacteria, Actinobacteria, Bacteroidetes, Cyanobacteria, Fibrobacteres, Firmicutes, Nitrospirae, OP9, Planctomycetes, Proteobacteria, Spirochaetes, TM6, Tenericutes, Verrucomicrobia and WS3. The OTUs were also determined and confirmed the abundance of Proteobacteria, Bacteroidetes, Firmicutes and Verrucomicrobia. It was possible to isolate several strains from the liquid media, and one bacterium and several fungi were found to produce interesting enzymatic activities. The bacterium Chryseobacterium sp. XAvLW produced α-amylase, β-glucosidase, endo-1,4-β-D-glucanase, endo-1,4-β-D-xylanase and filter paper-cellulase, while the fungi Sarocladium kiliense CTGxxyl and Trichoderma virens CTGxAviL generated the same activities added with endo-1,3-β-D-glucanase. [less ▲]

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See detailuelle définition du concept de tangente ? Pour quelles raisons ?
Balhan, Kevin ULg; Schneider-Gilot, Marguerite ULg; Krysinska, Marysa

in Repères : Revue des Instituts de Recherche sur l'Enseignement des Mathématiques (2015)

Dans le présent article, nous présentons un parcours didactique visant à faire évoluer chez les élèves le concept de tangente, de leur connaissance antérieure de tangente à un cercle comme droite ne ... [more ▼]

Dans le présent article, nous présentons un parcours didactique visant à faire évoluer chez les élèves le concept de tangente, de leur connaissance antérieure de tangente à un cercle comme droite ne coupant la courbe qu’en un seul point jusqu’à une définition formalisée au sein d’un cours d’analyse. Nous montrons ainsi qu’une définition d’un objet mathématique n’est ni définitive, ni une simple description de l’objet. Le choix d’une définition au détriment d’une autre doit se faire à la lumière d’un projet plus global relatif à l’institution à laquelle elle appartient. [less ▲]

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See detailEGFR and NF-kB: partners in cancer
Shostak, Kateryna ULg; Chariot, Alain ULg

in Trends in Molecular Medicine (2015), 21

Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival and invasiveness. Constitutive EGFR and NF-kappaB activities are seen in multiple solid ... [more ▼]

Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival and invasiveness. Constitutive EGFR and NF-kappaB activities are seen in multiple solid tumors and combine to provide oncogenic signals to cancer cells. Understanding how these oncogenic pathways are connected is critical, given their role in intrinsic or acquired resistance to targeted anti-cancer therapies. We review molecular mechanisms by which both EGFR- and NF-kappaB-dependent pathways establish positive loops to increase their oncogenic potential. We also describe how NF-kappaB promotes resistance to EGFR inhibitors. [less ▲]

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See detailLouis Althusser. Politique et subjectivité. Editorial
Bruschi, Fabio; Mancuso, Eva ULg

in Cahiers du GRM (2015), VII

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See detailAvis 2/13 de la CJUE : l'obsession du contrôle ?
Petit, Nicolas ULg; Pilorge, Joëlle ULg

in Revue des Affaires Européennes [= RAE] = Law & European Affairs (2015)

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See detailA comparative study of triaxial and uniaxial magnetic shields made out of YBCO coated conductors
Wera, Laurent ULg; Fagnard, Jean-François ULg; Levin, George et al

in Superconductor Science and Technology (2015), 28

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See detailQuaternary prevention: first, do not harm - Editorial
Jamoulle, Marc ULg

in Revista Brasileira de Medicina de Família e Comunidade (2015), 10(35), 1-3

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist ... [more ▼]

Clinical prevention, under the influence of public health, has been organised in a chronological manner since the middle of the 20th century. A paradigm shift from a chronological to a constructivist relationship-based preventive pattern of care offers new insights into the practice of doctors. This paradigm shift brings to light the concept of quaternary prevention, a critical look at medical activities with an emphasis on the need not to harm. Quaternary prevention addresses the fundamental question of what constitutes too much or too little medicine. It is the fourth form of disease prevention, but also the fourth frame of action for family doctors [less ▲]

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See detailThe strength of multi-row models
Louveaux, Quentin ULg; Poirrier, Laurent; Salvagnin, Domenico

in Mathematical Programming Computation (2015), 7(2), 113-148

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a ... [more ▼]

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a separating cut whenever one exists. The separator is not comparable in speed with the specific cutting-plane generators used in branch-and-cut solvers, but it is general-purpose. We can thus use it to compute cuts derived from any reasonably small relaxation PJ of a general mixed- integer problem, even when there exists no specific implementation for computing cuts with PJ. Exploiting this, we evaluate, from a computational perspective, the usefulness of cuts derived from several types of multi-row relaxations. In particular, we present results with four different strengthenings of the two-row intersection cut model, and multi-row models with up to fifteen rows. We conclude that only fully-strengthened two-row cuts seem to offer a significant advantage over two-row intersection cuts. Our results also indicate that the improvement obtained by going from models with very few rows to models with up to fifteen rows may not be worth the increased computing cost. [less ▲]

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See detailChitosan enriched three-dimensional matrix reduces inflammatory and catabolic mediators production by human chondrocytes
Oprenyeszk, Frédéric ULg; Sanchez, Christelle ULg; Dubuc, Jean-Emile et al

in PLoS ONE (2015), 10(5),

This in vitro study investigated the metabolism of human osteoarthritic (OA) chondrocytes encapsulated in a spherical matrix enriched of chitosan. Human OA chondrocytes were encapsulated and cultured for ... [more ▼]

This in vitro study investigated the metabolism of human osteoarthritic (OA) chondrocytes encapsulated in a spherical matrix enriched of chitosan. Human OA chondrocytes were encapsulated and cultured for 28 days either in chitosan-alginate beads or in alginate beads. The beads were formed by slowly passed dropwise either the chitosan 0.6%- alginate 1.2% or the alginate 1.2% solution through a syringe into a 102 mM CaCl2 solution. Beads were analyzed histologically after 28 days. Interleukin (IL)-6 and -8, prostaglandin (PG) E2, matrix metalloproteinases (MMPs), hyaluronan and aggrecan were quantified directly in the culture supernatant by specific ELISA and nitric oxide (NO) by using a colorimetric method based on the Griess reaction. Hematoxylin and eosin staining showed that chitosan was homogeneously distributed through the matrix and was in direct contact with chondrocytes. The production of IL-6, IL-8 and MMP-3 by chondrocytes significantly decreased in chitosan-alginate beads compared to alginate beads. PGE2 and NO decreased also significantly but only during the first three days of culture. Hyaluronan and aggrecan production tended to increase in chitosan-alginate beads after 28 days of culture. Chitosan-alginate beads reduced the production of inflammatory and catabolic mediators by OA chondrocytes and tended to stimulate the synthesis of cartilage matrix components. These particular effects indicate that chitosan-alginate beads are an interesting scaffold for chondrocytes encapsulation before transplantation to repair cartilage defects. [less ▲]

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See detailAutomated production at the curie level of no-carrier-added 6-[18F]fluoro-L-dopa and 2-[18F]fluoro-L-tyrosine on a FASTlab synthesizer
Lemaire, Christian ULg; Libert, Lionel; Franci, Xavier et al

in Journal of Labelled Compounds (2015), 58

An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in ... [more ▼]

An efficient, fully automated, enantioselective multi-step synthesis of no-carrier-added (nca) 6-[18F]fluoro-L-dopa ([18F]FDOPA) and 2-[18F]fluoro-L-tyrosine ([18F]FTYR) on a GE FASTlab synthesizer in conjunction with an additional high-performance liquid chromatography (HPLC) purification has been developed. A PTC (phase-transfer catalyst) strategy wasused to synthesize these two important radiopharmaceuticals. According to recent chemistry improvements, automationof the whole process was implemented in a commercially available GE FASTlab module, with slight hardware modificationusing single use cassettes and stand-alone HPLC. [18F]FDOPA and [18F]FTYR were produced in 36.3 ± 3.0 % (n = 8) and50.5 ± 2.7 % (n = 10) FASTlab radiochemical yield (decay corrected). The automated radiosynthesis on the FASTlab modulerequires about 52 min. Total synthesis time including HPLC purification and formulation was about 62 min. Enantiomericexcesses for these two aromatic amino acids were always >95 %, and the specific activity of was >740 GBq/μmol. Thisautomated synthesis provides high amount of [18F]FDOPA and [18F]FTYR (>37 GBq end of synthesis (EOS)). The process, fullyadaptable for reliable production across multiple PET sites, could be readily implemented into a clinical good manufacturingprocess (GMP) environment. [less ▲]

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See detailHow shattered flakes were used : Micro-wear analysis of quartz flake fragments
Knutsson, Helena; Knutsson, Kjel; Taipale, Noora ULg et al

in Journal of Archaeological Science: Reports (2015), 2

Prehistoric quartz assemblages have always posed a special problem for archaeologists. Due to its brittle nature, quartz is hard to understand within lithic classification systems that are based on ... [more ▼]

Prehistoric quartz assemblages have always posed a special problem for archaeologists. Due to its brittle nature, quartz is hard to understand within lithic classification systems that are based on formally varied flint assemblages. In this paper we explore ways to deal with this problem by applying two analytical methods, fracture analysis and use-wear analysis. A sample of 544 unmodified quartz flakes and flake fragments from Mesolithic and Neolithic sites in Sweden and Finland was analysed. It can be concluded that both whole and fragmented flakes were used as tools. Larger flakes and flake fragments were preferred as tool blanks and the type of use was correlated to variation in edge qualities rather than the formal characteristics of flakes. The results of this investigation suggest that making behavioural inferences from quartz assemblages with low formal variability requires the assemblages to be approached with a focus on functional types. [less ▲]

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See detailOn the use of the transmission disequilibrium test to detect pseudo-autosomal variants affecting traits with sex-limited expression
Elansary, Mahmoud ULg; Stinckens, Anneleen; Ahariz, Naïma ULg et al

in Animal Genetics (2015)

We herein describe the realization of a genome-wide association study for scrotal hernia and cryptorchidism in Norwegian and Belgian commercial pig populations. We have used the transmission ... [more ▼]

We herein describe the realization of a genome-wide association study for scrotal hernia and cryptorchidism in Norwegian and Belgian commercial pig populations. We have used the transmission disequilibrium test to avoid spurious associations due to population stratification. By doing so, we obtained genome-wide significant signals for both diseases with SNPs located in the pseudo-autosomal region in the vicinity of the pseudo-autosomal boundary. By further analyzing these signals, we demonstrate that the observed transmission disequilibria are artifactual. We determine that transmission bias at pseudo-autosomal markers will occur (i) when analyzing traits with sex-limited expression and (ii) when the allelic frequencies at the marker locus differ between X and Y chromosomes. We show that the bias is due to the fact that (i) sires will preferentially transmit the allele enriched on the Y (respectively X) chromosome to affected sons (respectively daughters) and (ii) dams will appear to preferentially transmit the allele enriched on the Y (respectively X) to affected sons (respectively daughters), as offspring inheriting the other allele are more likely to be non-informative. We define the conditions to mitigate these issues, namely by (i) extracting information from maternal meiosis only and (ii) ignoring trios for which sire and dam have the same heterozygous genotype. We show that by applying these rules to scrotal hernia and cryptorchidism, the pseudo-autosomal signals disappear, confirming their spurious nature. [less ▲]

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See detailAcetylene (C2H2) and hydrogen cyanide (HCN) from IASI satellite observations: global distributions, validation, and comparison with model
Duflot, V.; Wespes, C.; Clarisse, L. et al

in Atmospheric Chemistry & Physics Discussions (2015), 15(10), 14357--14401

We present global distributions of C2H2 and HCN total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI). These distributions are obtained with a fast method allowing to retrieve ... [more ▼]

We present global distributions of C2H2 and HCN total columns derived from the Infrared Atmospheric Sounding Interferometer (IASI). These distributions are obtained with a fast method allowing to retrieve C2H2 abundance globally with a 5% precision and HCN abundance in the tropical (subtropical) belt with a 10% (30%) precision. IASI data are compared for validation purposes with ground-based Fourier Transform Infrared (FTIR) spectrometer measurements at four selected stations. We show that there is an overall agreement between the ground-based and space measurements. Global C2H2 and subtropical HCN abundances retrieved from IASI spectra show the expected seasonality linked to variations in the anthropogenic emissions and seasonal biomass burning activity, as well as exceptional events, and are in good agreement with previous spaceborne studies. IASI measurements are also compared to the distributions from the Model for Ozone and Related Chemical Tracers, version 4 (MOZART- 4). Seasonal cycles observed from satellite data are reasonably well reproduced by the model. However, the model seems to overestimate (underestimate) anthropogenic (biomass burning) emissions and a negative global mean bias of 1% (16 %) of the model relative to the satellite observations was found for C2H2 (HCN). [less ▲]

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See detailGold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy
Liu, Ji; Detrembleur, Christophe ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Small (Weinheim an der Bergstrasse, Germany) (2015), 11(19), 2323-2332

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase ... [more ▼]

In this study, we report the synthesis of a nanoscaled drug delivery system, which is composed of a gold nanorod-like core and a mesoporous silica shell (GNR@MSNP) and partially uploaded with phase-changing molecules (1-tetradecanol, TD, Tm 39 degrees C) as gatekeepers, as well as its ability to regulate the release of doxorubicin (DOX). Indeed, a nearly zero premature release is evidenced at physiological temperature (37 degrees C), whereas the DOX release is efficiently achieved at higher temperature not only upon external heating, but also via internal heating generated by the GNR core under near infrared irradiation. When tagged with folate moieties, GNR@MSNPs target specifically to KB cells, which are known to overexpress the folate receptors. Such a precise control over drug release, combining with the photothermal effect of GNR cores, provides promising opportunity for localized synergistic photothermal ablation and chemotherapy. Moreover, the performance in killing the targeted cancer cells is more efficient compared with the single phototherapeutic modality of GNR@MSNPs. This versatile combination of local heating, phototherapeutics, chemotherapeutics and gating components opens up the possibilities for designing multifunctional drug delivery systems. [less ▲]

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See detailInfluence of substrate nature and β-lactoglobulin on cleanability after soiling by suspension spraying and drying
Toure, Yetioman ULg; Sindic, Marianne ULg; Dupont-Gillain, C. Christine et al

in Chemical Engineering Science (2015), 134

Glass and stainless steel (StSteel, AISI304-2R), previously cleaned with ethanol (-Eth) or with ethanol and UV–Ozone treatment (-UVO), were soiled with quartz suspensions in water and in a β-lactoglobulin ... [more ▼]

Glass and stainless steel (StSteel, AISI304-2R), previously cleaned with ethanol (-Eth) or with ethanol and UV–Ozone treatment (-UVO), were soiled with quartz suspensions in water and in a β-lactoglobulin (β-LGB) solution, and dried. The cleanability (ease of quartz particle detachment) in water was evaluated using a radial-flow cell. The soiling suspension containing β-LGB was used as such or after heating for 4h at 75°C, which provoked coagulation of about 75% of β-LGB. The substrate–solution interfaces were characterized by X-ray photoelectron spectroscopy (XPS) analysis of conditioned substrates and by contact angle measurements. The substrate surfaces are covered by a layer of organic contaminants which are not removed by pre-cleaning or are adsorbed from the surroundings. The presence of β-LGB in the soiling suspension leads to protein adsorption, but a significant amount of contaminants remains at the surface. For three of the substrates tested (Glass-Eth, Glass-UVO, StSteel-UVO) the increase of cleanability when the soiling suspension contained β-LGB may be explained by lower capillary forces acting upon drying. Capillary forces are proportional to the liquid surface tension and depend in a less important way on substrate contact angle. However the order of cleanability observed for the substrates soiled with a suspension of quartz particles in water (Glass-Eth≅Glass-UVO<StSteel-UVO<StSteel-Eth) and the influence of β-LGB on the cleanability of StSteel-Eth may not be explained only by computed capillary forces. The contact angle may exert a direct influence on droplet spreading and particle–substrate contact. The organic contaminants present on the surfaces, which are often neglected by supposing model solid surfaces, may have a significant influence on cleanability through physico-chemical processes which remain to be appreciated. [less ▲]

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See detailMeasurements on magnetized GdBCO pellets subjected to small transverse ac magnetic fields at very low frequency: Evidence for a slowdown of the magnetization decay
Fagnard, Jean-François ULg; Kirsch, Sébastien; Morita, Mitsuru et al

in Physica C: Superconductivity (2015), 512

Due to their ability to trap large magnetic inductions, superconducting bulk materials can be used as powerful permanent magnets. The permanent magnetization of such materials, however, can be ... [more ▼]

Due to their ability to trap large magnetic inductions, superconducting bulk materials can be used as powerful permanent magnets. The permanent magnetization of such materials, however, can be significantly affected by the application of several cycles of a transverse variable magnetic field. In this work, we study, at T = 77 K, the long term influence of transverse ac magnetic fields of small amplitudes (i.e. much smaller than the full penetration field) on the axial magnetization of a bulk single grain superconducting GdBCO pellet over a wide range of low frequencies (1 mHz–20 Hz). Thermocouples are placed against the pellet surface to probe possible self-heating of the material during the experiments. A high sensitivity cryogenic Hall probe is placed close to the surface to record the local magnetic induction normal to the surface. The results show first that, for a given number of applied triangular transverse cycles, higher values of dBapp/dt induce smaller magnetization decays. An important feature of practical interest is that, after a very large number of cycles which cause the loss of a substantial amount of magnetization (depending on the amplitude and the frequency of the field), the rate of the magnetization decay goes back to its initial value, corresponding to the relaxation of the superconducting currents due to flux creep only. In the amplitude and frequency range investigated, the thermocouples measurements and a 2D magneto-thermal modelling show no evidence of sufficient self-heating to affect the magnetization so that the effect of the transverse magnetic field cycles on the trapped magnetic moment is only attributed to a redistribution of superconducting currents in the volume of the sample and not to a thermal effect. [less ▲]

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See detailPolarization holography for vortex retarders recording: laboratory demonstration
Piron, Pierre ULg; Blain, Pascal ULg; Décultot, Marc ULg et al

in Applied Optics (2015), 54(15), 4765--4770

This paper will present a prototype of the first set of vortex retarders made of liquid crystal polymers recorded by polarization holography. Vortex retarders are birefringent plates characterized by a ... [more ▼]

This paper will present a prototype of the first set of vortex retarders made of liquid crystal polymers recorded by polarization holography. Vortex retarders are birefringent plates characterized by a rotation of their fast axis. Liquid crystals possess birefringent properties and they are locally orientable. Their orientation is defined by the perpendicular to the local orientation of the recording field. Polarization holography is a purely optical recording method. It is based on the superimposition of coherent and differently polarized beams. It is used to shape the electric field pattern to enable the recording of vortex retarders. The paper details the mathematical model of the superimposition process. The recording setup is exposed; it is characterized by a nearly common path interferometer. Two sets of measurements allowing the prediction of the retarder’s features are presented and compared. Finally, the experimentally recorded retarder is shown, its characteristics are investigated and compared to the predicted ones. [less ▲]

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See detailThe utility of Google Scholar when searching geographical literature: comparison with three commercial bibliographic databases
Stirbu, Simona ULg; Thirion, Paul ULg; Schmitz, Serge ULg et al

in Journal of Academic Librarianship (2015), 41(3), 322-329

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science ... [more ▼]

This study aims to highlight what benefits, if any, Google Scholar (GS) has for academic literature searches in the field of geography, compared to three commercial bibliographic databases: Web of Science (WoS) and FRANCIS (multidisciplinary databases) and GeoRef (specialized in geosciences). To ensure a valid comparison, identical bibliographic searches were applied using each of the four bibliographic tools. To exclude automatic variations of the ten keywords tested, they were placed between quotation marks and searched only in the “title” field of the respective search tools’ interfaces. The results were limited to bibliographic references published from 2005 to 2009. In order to assess the repeatability of the results, the exact same process was repeated monthly between November 2010 and July 2011. Initially the whole set of results was analyzed, after which the search results for two keywords (selected since they yielded a manageable number of results) were studied in more detail. The results indicate that GS search results show a large degree of overlap with those of the other databases but, moreover, yield numerous unique hits, which should be useful to researchers in both the fields of human and physical geography. GS leads the other tools widely on number of results, independently of keyword, subfield, year of publication, or time of search. [less ▲]

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See detailCortical reorganization in an astronaut's brain after long-duration spaceflight.
Demertzi, Athina ULg; Van Ombergen, Angelique; Tomilovskaya, Elena et al

in Brain Structure & Function (2015)

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in ... [more ▼]

To date, hampered physiological function after exposure to microgravity has been primarily attributed to deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain function after long-duration spaceflight. More specifically, we found significant differences in resting-state functional connectivity between motor cortex and cerebellum, as well as changes within the default mode network. In addition, the cosmonaut showed changes in the supplementary motor areas during a motor imagery task. These results highlight the underlying neural basis for the observed physiological deconditioning due to spaceflight and are relevant for future interplanetary missions and vestibular patients. [less ▲]

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See detailFoamability and Foam Stability of Male and Female Date Palm Sap (Phoenix dactylifera L.) During the Collection Period
Makhlouf-gafsi, Ines; Mokni-ghribi, Abir; Bchir, Brahim et al

in Food Biophysics (2015)

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming ... [more ▼]

This work aimed to study the influence of date palm sex on the surface properties of date palm sap (DPS) (Phoenix dactylifera L.) during the collection period. The behavior at the interface and foaming properties were evaluated via equilibrium surface tension (drop volume) and bubbling method, respectively. Unlike male sap, the female sap was unable to produce foam due to its low rate of adsorption, low average hydrophobicity values, and low bulk viscosity values throughout the collection period. For male sap, there are significant differences (p<0.05) on foaming properties throughout the collection period. In fact, the last 3 weeks of sap collection were characterized by a decrease pace of surface tension which explains the enhancement of both foam capacity and stability. The last week of collection period present the best foam power (0.9). To explain these differences, the interactions of several factors and their affects on foaming properties were examined. Results showed a positive correlation between foam capacity and average hydrophobicity values. In the other hand, foam stability exhibits a positive correlation with the increase of protein concentration and bulk viscosity. [less ▲]

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See detailAntimicrobial, antitumor and brine shrimp lethality assay of Ranunculus arvensis L. extracts
Muhammad Zeeshan Bhatti; Ali, Amjad ULg; Asma Saeed et al

in Pakistan Journal of Pharmaceutical Sciences (2015)

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE ... [more ▼]

To investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of Methanol Extract (ME), Water Extract (WE), Acetone Extract (AE), Chloroform Extract (CE), Methanol-Water Extract (MWE), Methanol-Acetone Extract (MAE), Methanol-Chloroform Extract (MCE) of Ranunculus arvensis (L.). Antitumor activity was evaluated with Agrobacterium tumefaciens (At10) induced potato disc assay. Cytotoxicity was evaluated with brine shrimp lethality assay. Antibacterial activity was evaluated with six bacterial strains including Escherichia coli, Enterobacter aerogenes, Bordetella bronchiseptica, Klebsiella pneumoniae, Micrococcus luteus and Streptococcus anginosus and antifungal screening was done against five fungal strains including Aspergillus niger, A. flavus, A. fumigates, Fusarium solani and Mucor species by using disc diffusion method. Best antitumor activity was obtained with ME and WE, having highest IC50 values 20.27±1.62 and 93.01±1.33μg/disc. Brine shrimp lethality assay showed LC50 values of AE, MAE and ME were obtained as 384.66±9.42μg/ml, 724.11±8.01μg/ml and 978.7±8.01μg/ml respectively. WE of R. arvensis revealed weak antimicrobial result against the tested microorganisms. On the other hand, the antifungal activity of the plant extracts was found to be insignificant. These findings demonstrate that extracts of R. arvensis possesses significant antitumor activity. Further extensive study is necessary to assess the therapeutic potential of the plant [less ▲]

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See detailLipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
Brohée, Laura ULg; Demine, Stéphane; Willems, Jérôme ULg et al

in Oncotarget (2015), 6(13), 11264-11280

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the ... [more ▼]

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able to regulate lipid homeostasis at several nodal points. Here, we show that lipin-1 is up-regulated in several cancer cell lines and overexpressed in 50 % of high grade prostate cancers. The proliferation of prostate and breast cancer cells, but not of non-tumorigenic cells, was repressed upon lipin-1 knock-down. Lipin-1 depletion also decreased cancer cell migration through RhoA activation. Lipin-1 silencing did not significantly affect global lipid synthesis but enhanced the cellular concentration of phosphatidic acid. In parallel, autophagy was induced while AKT and ribosomal protein S6 phosphorylation were repressed. We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone. Most interestingly, lipin-1 depletion or lipins inhibition with propranolol sensitized cancer cells to rapamycin. These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. [less ▲]

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See detailFuture climate and surface mass balance of Svalbard glaciers in an RCP8.5 climate scenario: a study with the regional climate model MAR forced by MIROC5
Lang, Charlotte ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Cryosphere (The) (2015), 9

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the ... [more ▼]

We simulated the 21st century Svalbard SMB with the regional model MAR (RCP8.5 scenario). Melt is projected to increase gently up to 2050 and then dramatically increase, with a larger increase in the south of the archipelago. This difference is due to larger ice albedo decrease in the south causing larger increase of absorbed solar radiation. The ablation area is projected to disappear over the entire Svalbard by 2085. The SMB decrease compared to present is projected to contribute 7mm to SLR. [less ▲]

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See detailArmée européenne : quelle phase transitoire ?
Dumoulin, André ULg

in Europe Diplomatie & Défense (2015), (792), 3

Page Idées sur la nécessité de créer les conditions d'une Union européenne de sécurité et de défense (UESD) à partir de quelques Etats membres de l'UE

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See detailChitosan-coated electrospun nanofibers with antibacterial activity
Croisier, Florence ULg; Sibret, Pierre ULg; Dupont-Gillain, Christine C. et al

in Journal of Materials Chemistry B (2015), 3(17), 3508-2517

Charged nanofibers were prepared by electrospinning (ESP) poly(ε-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on ... [more ▼]

Charged nanofibers were prepared by electrospinning (ESP) poly(ε-caprolactone) with a copolymer bearing carboxylic acid functions. The presence of these functions allowed exposing some negative charges on the fiber surface, by dipping the fibers in a phosphate buffer. A layer of chitosan, a polycation in acidic medium, was then deposited on the nanofiber surface, thanks to electrostatic attraction. Fibers were characterized at each step of the process and the influence of the copolymer architecture on chitosan deposition was discussed. The antibacterial activity of the resulting fibers was finally assessed. [less ▲]

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See detailA fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae
Zune, Quentin ULg; Delepierre, Anissa ULg; Gofflot, Sebastien et al

in Applied Microbiology and Biotechnology (2015)

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical ... [more ▼]

Fungal biofilm is known to promote the excretion of secondary metabolites in accordance with solid-state related physiological mechanisms. This work is based on the comparative analysis of classical submerged fermentation with a fungal biofilm reactor for the production of a Gla::GFP fusion protein by Aspergillus oryzae. The biofilm reactor comprises a metal structured packing allowing the attachment of the fungal biomass. Since the production of the target protein is under the control of the promoter glaB, specifically induced in solid-state fermentation, the biofilm mode of culture is expected to enhance the global productivity. Although production of the target protein was enhanced by using the biofilm mode of culture, we also found that fusion protein production is also significant when the submerged mode of culture is used. This result is related to high shear stress leading to biomass autolysis and leakage of intracellular fusion protein into the extracellular medium. Moreover, 2D-gel electrophoresis highlights the preservation of fusion protein integrity produced in biofilm conditions. Two fungal biofilm reactor designs were then investigated further, i.e. with full immersion of the packing or with medium recirculation on the packing, and the scale-up potentialities were evaluated. In this context, it has been shown that full immersion of the metal packing in the liquid medium during cultivation allows for a uniform colonization of the packing by the fungal biomass and leads to a better quality of the fusion protein. [less ▲]

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See detailMetabolomic analysis of the green microalga Chlamydomonasreinhardtii cultivated under day/night conditions
Willamme, Rémi ULg; Alsafra, Zouheir; Arumugam, Rameshkumar et al

in Journal of Biotechnology (2015)

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See detailInfluence of bottom currents on the sedimentary processes at the western tip of the Gulf of Corinth, Greece
Beckers, Arnaud ULg; Beck, Christian; Hubert, Aurelia ULg et al

in Marine Geology (2015)

We investigated the sedimentary processes that were active during the Holocene in the Gulf of Corinth, using high-resolution seismic reflection profiles and gravity cores. Seismic reflection data clearly ... [more ▼]

We investigated the sedimentary processes that were active during the Holocene in the Gulf of Corinth, using high-resolution seismic reflection profiles and gravity cores. Seismic reflection data clearly show the presence of shallow-water sediment drifts at the western end of the Gulf, close to the Rion Sill that links the gulf to the Ionian Sea. Short cores indicate that drifts are composed of homogenous bioturbated mud in their upper part. The drift deposits flank a wide central area where the sea floor is eroded and where pre-Holocene deposits locally outcrop. The sea floor morphology in this area is marked by furrows oriented in different directions and by a depression attributed to the action of bottom-currents. The magnetic fabric of sediment samples from the drift, shelves, sub-basins and from the basin floor show a significant anisotropy and a similar orientation of Kmax axes along core. The largest anisotropy (P = 1.043 ± 0.007) is observed in the drift and is interpreted as resulting from the action of bottom currents. The similar orientation of Kmax axes in the other cores, collected from areas East of the drifts, suggests that bottom currents also affect sediment deposition in the rest of the study area, even if seismic profiles and core analyses demonstrate that gravitational processes such as submarine landslides and turbidity currents exert the main control on sediment transport and deposition. Average Kmax axes for four cores were reoriented using the declination of the characteristic remanent magnetization. Kmax axes show variable orientations relatively to the slope of the sea floor, between along-slope and roughly parallel to the contour lines. [less ▲]

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See detailPhotometric identification of the periods of the first candidate extragalactic magnetic massive stars
Nazé, Yaël ULg; Walborn, Nolan R.; Morrell, Nidia et al

in Astronomy and Astrophysics (2015), 577

Galactic stars belonging to the Of?p category are all strongly magnetic objects exhibiting rotationally modulated spectral and photometric changes on timescales of weeks to years. Five candidate Of?p ... [more ▼]

Galactic stars belonging to the Of?p category are all strongly magnetic objects exhibiting rotationally modulated spectral and photometric changes on timescales of weeks to years. Five candidate Of?p stars in the Magellanic Clouds have been discovered, notably in the context of ongoing surveys of their massive star populations. Here we describe an investigation of their photometric behaviour, revealing significant variability in all studied objects on timescales of one week to more than four years, including clearly periodic variations for three of them. Their spectral characteristics along with these photometric changes provide further support for the hypothesis that these are strongly magnetized O stars, analogous to the Of?p stars in the Galaxy. [less ▲]

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See detailPerformance-Based Aid: Why it will probably not meet promises
Paul, Elisabeth ULg

in Development Policy Review (2015), 33(3),

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with ... [more ▼]

Performance-based aid (PBA) is increasingly advocated as a way to improve development aid effectiveness through resolving incentive issues inherent in aid relationships. Some donors use PBA together with performance-based financing arrangements within partner countries. Expectations from PBA are high – yet, while its rationale may look appealing, it is grounded on a restrictive model and flawed when taking account of real-world context. A number of problems associated to PBA have already been advanced as jeopardising its success. More fundamentally, one may question the mere appropriateness of PBA to provide incentives all along the chain from recipient governments to those who are supposed to produce results. Thus believing that PBA can have a mechanistic trickle-down incentive effect seems an illusion. [less ▲]

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See detailLe droit européen de l’abus de position dominante en 2014
Petit, Nicolas ULg

in Contrats Concurrence Consommation (2015)

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See detailOlympic stadiums and Cultural heritage: on the nature and status of heritage values in large sport facilities.
Kiuri, Miranda; Teller, Jacques ULg

in International Journal of the History of Sport (2015)

This paper investigates Olympic stadium heritage values and their cultural significance. It outlines the main challenges in stadium conservation through the interplay between bequest and use values. A ... [more ▼]

This paper investigates Olympic stadium heritage values and their cultural significance. It outlines the main challenges in stadium conservation through the interplay between bequest and use values. A value analysis of listed Olympic stadiums reveals that these are characterized by a specific heritage profile, related to the uniqueness and singularity of the buildings, of the landscape and of the sporting event. The history of architecture and sport are clearly interwoven in these places, as Olympic stadiums appear as testimonies of the evolution of sport and its status for past and present societies. Such an interpretation of Olympic stadium heritage could allow a better Olympic and sporting heritage evaluation and conservation, especially if the ensemble of existing Olympic stadiums was considered as a World Heritage network. [less ▲]

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See detailA comparison of within-season yield prediction algorithms based on crop model behaviour analysis
Dumont, Benjamin ULg; Basso, Bruno; Leemans, Vincent ULg et al

in Agricultural and Forest Meteorology (2015), 204

The development of methodologies for predicting crop yield, in real-time and in response to different agro-climatic conditions, could help to improve the farm management decision process by providing an ... [more ▼]

The development of methodologies for predicting crop yield, in real-time and in response to different agro-climatic conditions, could help to improve the farm management decision process by providing an analysis of expected yields in relation to the costs of investment in particular practices. Based on the use of crop models, this paper compares the ability of two methodologies to predict wheat yield (Triticum aestivum L.), one based on stochastically generated climatic data and the other on mean climate data. It was shown that the numerical experimental yield distribution could be considered as a log-normal distribution. This function is representative of the overall model behaviour. The lack of statistical differences between the numerical realisations and the logistic curve showed in turn that the Generalised Central Limit Theorem (GCLT) was applicable to our case study. In addition, the predictions obtained using both climatic inputs were found to be similar at the inter and intra-annual time-steps, with the root mean square and normalised deviation values below an acceptable level of 10% in 90% of the climatic situations. The predictive observed lead-times were also similar for both approaches. Given (i) the mathematical formulation of crop models, (ii) the applicability of the CLT and GLTC to the climatic inputs and model outputs, respectively, and (iii) the equivalence of the predictive abilities, it could be concluded that the two methodologies were equally valid in terms of yield prediction. These observations indicated that the Convergence in Law Theorem was applicable in this case study. For purely predictive purposes, the findings favoured an algorithm based on a mean climate approach, which needed far less time (by 300-fold) to run and converge on same predictive lead time than the stochastic approach. [less ▲]

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See detailExpression of sexual ornaments in a polymorphic species: phenotypic variation in response to environmental risk
Winandy, Laurane ULg; Denoël, Mathieu ULg

in Journal of Evolutionary Biology (2015), 28(5), 1049-1056

Secondary sexual traits may evolve under the antagonistic context of sexual and natural selection. In some polymorphic species, these traits are only expressed during the breeding period and are ... [more ▼]

Secondary sexual traits may evolve under the antagonistic context of sexual and natural selection. In some polymorphic species, these traits are only expressed during the breeding period and are differently expressed in alternative phenotypes. However, it is unknown whether such phenotypes exhibit phenotypic plasticity of seasonal ornamentations in response to environmental pressures such as in the presence of fish (predation risk). This is an important question to understand the evolution of polyphenisms. We used facultative paedomorphosis in newts as a model system because it involves the coexistence of paedomorphs that retain gills in the adult stage with metamorphs that have undergone metamorphosis, but also because newts exhibit seasonal sexual traits. Our aim was therefore to determine the influence of fish on the development of seasonal ornamentation in the two phenotypes of the palmate newt (Lissotriton helveticus). During the entire newt breeding period, we assessed the importance of phenotype and fish presence with an information-theoretic approach. Our results showed that paedomorphs presented much less developed ornamentation than metamorphs and those ornamentations varied over time. Fish inhibited the development of sexual traits but differently between phenotypes: in contrast to metamorphs, paedomorphs lack the phenotypic plasticity of sexual traits to environmental risk. This study points out that internal and external parameters act in complex ways in the expression of seasonal sexual ornamentations and that similar environmental pressure can induce a contrasted evolution in alternative phenotypes. [less ▲]

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