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See detailAdresse, opinion et responsabilité : un modèle de la subjectivation en public
Servais, Christine ULg

in Questions de Communication (2017)

Cet article interroge la relation entre « publics » et « collectifs » et en propose un modèle de description à caractère phénoménologique. Après un examen des implications politiques des modèles auxquels ... [more ▼]

Cet article interroge la relation entre « publics » et « collectifs » et en propose un modèle de description à caractère phénoménologique. Après un examen des implications politiques des modèles auxquels sont susceptibles de se référer les théories de la réception médiatique, on tente d’élaborer, à partir du travail de Stiegler, de Rancière et de Derrida, une approche de la réception qui permet de décrire à la fois l’émancipation et la domination, cette alternative étant l’un des points de butée des théories de la réception. Le critère déterminant est ici l’adresse, considérée comme la traduction en termes phénoménologiques de l’énonciation. La réception est alors envisagée comme une réponse à une adresse. Cette conception de l’énonciation rend compte de la dimension politique d’une réception médiatique où l’identité sociale est désormais indexée sur notre identité de destinataires de dispositifs médiatique, c’est-à-dire de publics [less ▲]

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See detailPostoperative care in endoscopic sinus surgery: a critical review.
Eloy, Philippe; Andrews, Peter; POIRRIER, Anne-Lise ULg

in Current Opinion in Otolaryngology & Head & Neck Surgery (2017), 25(1), 35-42

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard ... [more ▼]

PURPOSE OF REVIEW: Chronic rhinosinusitis with and without nasal polyps is a common disease affecting people all over the world. Functional endoscopic sinus surgery (FESS) has become the gold standard treatment for medically refractive disease. Postoperative care is recommended by international leaders as an important part of the patient's management. This article is a critical review and discussion focusing on postoperative care, which is based on expert opinion, clinical studies, randomized controlled trials and meta-analysis studies. RECENT FINDINGS: Postoperative care including nasal rinsing, topical corticosteroids, antibiotics and avoidance of nasal packing are unanimously considered to be the cornerstone of best practice following FESS. However, the effectiveness of in-office nasal debridement is still under debate. SUMMARY: There is a lack of consensus regarding the necessity of performing in-office nasal debridement and the majority of clinicians carry out their postoperative care according to experience and their own preference. This is often determined by the extent of surgery performed, the severity of the postoperative inflammation, as well as being dependent on the patient's discomfort, the time constraints associated with postoperative care and the costs associated with additional appointments. Ideally, nasal debridement should be performed by the operating surgeon under endoscopic control both gently and atraumatically. [less ▲]

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See detailNonlinear system identification in structural dynamics: 10 more years of progress
Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Mechanical Systems & Signal Processing (2017), 83

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved ... [more ▼]

Nonlinear system identification is a vast research field, today attracting a great deal of attention in the structural dynamics community. Ten years ago, in an MSSP paper reviewing the progress achieved until then, it was concluded that the identification of simple continuous structures with localised nonlinearities was within reach. The past decade witnessed a shift in emphasis, accommodating the growing industrial need for a first generation of tools capable of addressing complex nonlinearities in larger-scale structures. The objective of the present paper is to survey the key developments which arose in the field since 2006, and to illustrate state-of-the-art techniques using a real-world satellite structure. Finally, a broader perspective to nonlinear system identification is provided by discussing the central role played by experimental models in the design cycle of engineering structures. [less ▲]

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See detailPreparing physically educated citizens in physical education. Expectations and practices
Cloes, Marc ULg

in Retos (2017), 31

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being ... [more ▼]

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being increasingly linked to the promotion of physically active lifestyles. In this paper, we try to determine whether practitioners have the capacity to reach recent objectives for the subject or should reconsider their work on this issue. Moreover, we propose to extend the current focus on physical literacy to encompass the concept of societal transfer, underlining the need for an authentic pedagogy of PE. [less ▲]

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See detailShip collision analysis on Offshore Wind Turbine monopile foundations
Bela, Andreea ULg; Le Sourne, Hervé; Buldgen, Loïc ULg et al

in Marine Structures (2017), 51

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in ... [more ▼]

An offshore wind farm covers a large maritime area and the site can be located close to traffic lanes of commercial and passenger ships, which may lead to possible collision events. The work presented in this paper aimed to understand both the crushing behavior and the nacelle dynamics of a predefined monopile offshore wind turbine when impacted by a ship. Another objective was to deeply investigate the influence of various parameters like ship impact velocity and location, wind direction, soil stiffness and deformability of the striking ship. First, nonlinear numerical simulations of ship - Offshore Wind Turbine (OWT) collisions have been carried out with a rigid striking ship for a better understanding of the OWT’s structural behaviour during collision. Different configurations for the wind turbine’s structure have been used in order to highlight the modifications in behaviour induced by changing the soil conditions or the loading scenario. The resulting resistant force and internal energies have been compared as well as the tower top (nacelle) displacements and accelerations. Then, another series of simulations have been performed with a deformable ship in order to investigate the influence of the deformability of the striking ship on the OWT’s behaviour. It is worth noting that all these numerical results will further serve to fix the hypotheses for the development of a simplified tool based on analytical formulations. [less ▲]

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See detailSustainability and management control. Exploring and theorizing control patterns in large European firms
Crutzen, Nathalie ULg; Zvezdov, Dimitar; Schaltegger, Stefan

in Journal of Cleaner Production (2017), 143

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See detailDesign sensitivity analysis for shape optimization based on the Lie derivative
Kuci, Erin ULg; Henrotte, François ULg; Duysinx, Pierre ULg et al

in Computer Methods in Applied Mechanics & Engineering (2017)

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed ... [more ▼]

Abstract The paper presents a theoretical framework for the shape sensitivity analysis of systems governed by partial differential equations. The proposed approach, based on geometrical concepts borrowed from differential geometry, shows that sensitivity of a performance function (i.e. any function of the solution of the problem) with respect to a given design variable can be represented mathematically as a Lie derivative, i.e. the derivative of that performance function along a flow representing the continuous shape modification of the geometrical model induced by the variation of the considered design variable. Theoretical formulae to express sensitivity analytically are demonstrated in detail in the paper, and applied to a nonlinear magnetostatic and a linear elastic problem, following both the direct and the adjoint approaches. Following the analytical approach, one linear system of which only the right-hand side needs be evaluated (the system matrix being known already) has to be solved for each of the design variables in the direct approach, or for each performance functions in the adjoint approach. A substantial gain in computation time is obtained this way compared to a finite difference evaluation of sensitivity, which requires solving a second nonlinear system for each design variable. This is the main motivation of the analytical approach. There is some freedom in the definition of the auxiliary flow that represents the shape modification. We present a method that makes benefit of this freedom to express sensitivity locally as a volume integral over a single layer of finite elements connected to both sides of the surfaces undergoing shape modification. All sensitivity calculations are checked with a finite difference in order to validate the analytic approach. Convergence is analyzed in 2D and 3D, with first and second order finite elements. [less ▲]

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See detailChemical Composition and Acaricidal Activity of Thymus algeriensis Essential Oil against Varroa destructor
Kouache, Benmoussa; Brada, Moussa; Saadi, Abdelkader et al

in Natural Product Communications (2017), 12(0), 1-4

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is ... [more ▼]

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is a pest of the honey bee Apis mellifera. The essential oil from the aerial parts of T. algeriensis, obtained by hydrodistillation, was obtained in a yield of 2.8± 0.2%, w/w. The TAEO was analyzed by GC and GC/MS. Thirty-four compounds were identified, representing 99.3% of the oil. The main constituents were carvacrol (48.4%), γ-terpinene (14.9%), p-cymene (14.7%), and thymol (5.6%). Four lots were constituted at the level of an apiary in order to study the dynamics of the Varroa destructor and its host, Apis mellifera. After diagnosis by the biological method "install of diapers", the lots were treated at different doses of TAEO (0.1, 0.3 and 0.5%). TAEO was sprayed on top of the hives. The results show that TAEO at 0.5% resulted in a decrease in the rate of infestation of Varroa destructor, causing a mortality rate of 32.6% without negative effect on the nesting of the queen. The essential oil of T. algeriensis could be used as a bioacaricidal agent. [less ▲]

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULg; Della Vecchia, Gabriele; Charlier, Robert ULg

in Canadian Geotechnical Journal (2017)

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See detailSartre, le XXe siècle
Cormann, Grégory ULg

in Médium (2017), 50

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See detailIncreased expression of bacterial amoA during an N2O emission peak in an agricultural field
Theodorakopoulos, Nicolas ULg; Lognoul, Margaux ULg; Degrune, Florine ULg et al

in Agriculture, Ecosystems & Environment (2017), 236

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak ... [more ▼]

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak on a maize crop after a natural rainfall. The peak occurred rapidly after the rainfall began. Spatial and temporal variability in N2O emission was observed between chambers. An analysis of N-cycle gene transcript levels revealed an increase in bacterial amoA gene transcripts (but not in archaeal amoA transcripts), correlating strongly with N2O emission. This suggests the involvement of nitrification enzymes, despite a high water-filled pore space (80%). Reverse transcription of bacterial 16S rRNA followed by partial sequencing of the resulting cDNAs revealed few rainfall-induced changes in the potentially active bacterial community, and notably no significant change in the relative abundance of 16S rRNAs from the nitrifier genus Nitrosospira. Expression of the amoA gene appears as a possible proxy for monitoring the N2O emission peak. To our knowledge, this is the first experiment to evaluate the expression of N-cycle genes during an N2O emission peak on an agricultural field. [less ▲]

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See detailChemical profiling of the major components in natural waxes to elucidate their role in liquid oil structuring
Doan, Chi Diem; To, Chak Ming; De Vrieze, Mike et al

in Food Chemistry (2017), 214

Elucidating the composition of waxes is of utmost importance to explain their behavior in liquid oil structuring. The chemical components (hydrocarbons – HCs, free fatty acids – FFAs, free fatty alcohols ... [more ▼]

Elucidating the composition of waxes is of utmost importance to explain their behavior in liquid oil structuring. The chemical components (hydrocarbons – HCs, free fatty acids – FFAs, free fatty alcohols – FALs and wax esters – WEs) of natural waxes were analyzed using HPLC–ELSD and GC–MS followed by evaluation of their oil structuring properties. The gel strength, including the average storage modulus and oscillation yield stress, displayed a negative correlation with FALs and a positive correlation with HCs, FFAs and WEs. The components dictating the gel strength are HCs, FFAs and WEs in a descending order of importance. The consistency of the oleogels increased with the increasing amount of FFAs and HCs and the decreasing amount of WEs and FALs. The presence of more WEs results in a strong but brittle gel with a high initial flow yield stress. We believe these results might be useful in selecting the right waxes to combine in certain fat-based food products. [less ▲]

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See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULg; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailLe commun à l'épreuve du conflit : médiation esthétique et expérience de la communauté
Servais, Christine ULg

in Recherches en Communication (2017)

Cet article propose une conception de la médiation culturelle où la notion de médiation est lestée d’un rapport complexe au tiers, rapport susceptible de prendre en compte le conflit que peut constituer ... [more ▼]

Cet article propose une conception de la médiation culturelle où la notion de médiation est lestée d’un rapport complexe au tiers, rapport susceptible de prendre en compte le conflit que peut constituer la prise de position du destinataire auquel s’adressent les dispositifs de médiation. Cette approche de la médiation conserve la distinction entre passage et forçage, ce qui la situe dans un cadre politique. [less ▲]

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See detailHow does forest cover impact water flows and ecosystem services? Insights from real-life catchments in Wallonia (Belgium)
Brogna, Delphine; Vincke, Caroline; Brostaux, Yves ULg et al

in Ecological Indicators (2017), 72

While planet boundaries are being crossed and ecosystems degraded, the Ecosystem Service (ES) conceptrepresents a potential decision-making tool for improved natural resources management. The main aimof ... [more ▼]

While planet boundaries are being crossed and ecosystems degraded, the Ecosystem Service (ES) conceptrepresents a potential decision-making tool for improved natural resources management. The main aimof this paper is to assess the impact of forest cover on water related ES in Wallonia (Belgium) in termsof quantity and timing. We developed an approach based on easily accessible data, monitored in severalcountries and using straightforward statistical methods. This led us to study ES at “real-life” catchmentsscale: 22 catchments – from 30 to 250 km2– with mixed land covers were studied. We approached thewater supply and flood protection services through 5 indicators extracted from 10 hydrological years(2005–2014) discharge data series. These were computed annually and seasonally (vegetation periodfrom March to September and “non-vegetation” period the rest of the year). The water supply wasassessed through the specific volume Vs, the baseflow index BFI and the specific discharge exceeded95% of the time Q95s whereas the flood protection service was approached through the specific dis-charge exceeded 5% of the time Q05s and the flashiness index FI. Our study gives two main insights. First,statistical analyses show that forest cover negatively impact water supply when studying annual and“non-vegetation” period flows in general (Vs) but positively when studying low flows (Q95s). Regardingflood protection a slightly negative impact of forest cover on high flows (Q05s) was highlighted in the“non-vegetation” period. Results also show a negative impact of forests annually and in the vegetationperiod on the flashy behaviour of the catchment thus a positive impact on the flood protection ES. The“year” effect is overall highly significant testifying the importance of climatic factors. Rainfall is oftensignificant and can be considered as a main driver of these ES. Secondly, analyzing the quality of themodels produced and the results overall we assume that other variables characterizing the catchmentssuch as topography or soil types do play a significant role in the delivery of these ES. This questions theuse of land cover proxies in assessing and mapping of hydrological ES at a complex landscape scale. Wethus recommend further research to keep improving land cover proxies if they are used. [less ▲]

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See detailCabergoline for Cushing's disease: a large retrospective multicenter study.
Ferriere, A.; Cortet, C.; Chanson, P. et al

in European Journal of Endocrinology (2017), 176(3), 305-314

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of ... [more ▼]

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded. RESULTS: Twenty-one (40%) of 53 patients who received cabergoline monotherapy had normal urinary free cortisol (UFC) values within 12 months (complete responders), and five of these patients developed corticotropic insufficiency. The fall in UFC was associated with significant reductions in midnight cortisol and plasma ACTH, and with clinical improvement. Compared to other patients, complete responders had similar median baseline UFC (2.0 vs 2.5xULN) and plasma prolactin concentrations but received lower doses of cabergoline (1.5 vs 3.5 mg/week, P < 0.05). During long-term treatment (>12 months), cabergoline was withdrawn in 28% of complete responders because of treatment escape or intolerance. Overall, sustained control of hypercortisolism was obtained in 23% of patients for 32.5 months (19-105). Nine patients on steroidogenesis inhibitors received cabergoline add-on therapy for 19 months (1-240). Hypercortisolism was controlled in 56% of these patients during the first year of treatment with cabergoline at 1.0 mg/week (0.5-3.5). CONCLUSIONS: About 20-25% of CD patients are good responders to cabergoline therapy allowing long-term control of hypercortisolism at relatively low dosages and with acceptable tolerability. No single parameter, including the baseline UFC and prolactin levels, predicted the response to cabergoline. [less ▲]

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See detailSharing powers within exclusive competences: rethinking EU competition law enforcement
Van Cleynenbreugel, Pieter ULg

in Croatian Yearbook of European Law & Policy (2017), 12

Although the establishment of competition rules forms part of the EU’s exclusive competences, the application and enforcement of those rules has always been shared consistently between the EU and its ... [more ▼]

Although the establishment of competition rules forms part of the EU’s exclusive competences, the application and enforcement of those rules has always been shared consistently between the EU and its Member States. The sharing of enforcement powers is conceptualised traditionally as a delegation of the exercise of exclusively conferred competences. The Court of Justice of the European Union’s case law in the context of EU antitrust law enforcement nevertheless raises profound questions as to the overall tenability of this delegation framework in this particular field of EU exclusive competence. This contribution argues the traditional exclusive competences narrative indeed fails to grasp the system of shared enforcement powers underlying EU antitrust law. Seeking to make sense of the realities of that system in light of EU competence doctrines, it explores the constitutionality of legal policy strategies enabling a more explicit recognition of shared competences principles as an inherent part of this EU exclusive competence domain. [less ▲]

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULg et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULg; Dassargues, Alain ULg et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailA vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka.
Yu, T; Graf, M; Renn, Jörg ULg et al

in Development (2017), 144(2), 265-271

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation ... [more ▼]

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Sp7/Osx for bone formation also in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation. [less ▲]

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See detailTransdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al

in American Journal of Surgical Pathology (2017)

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a ... [more ▼]

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed. [less ▲]

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See detailFluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state
Van Calster, Laurens ULg; D'Argembeau, Arnaud ULg; SALMON, Eric ULg et al

in Journal of Cognitive Neuroscience (2017)

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's ... [more ▼]

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes. [less ▲]

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See detailEvaluation d'un itinéraire clinique pour collectomie gauche en chirurgie abdominale
Mattart, Laurine; Stevens, Marie; Magis, David ULg et al

in Revue Médicale de Liège (2017), 72(1), 45-50

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne ... [more ▼]

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne nécessitant une résection du côlon gauche par laparoscopie a été incluse dans cet IC entre 2009 et 2015. Nous nous sommes intéressés à l’observance du protocole de l’IC ainsi qu’aux taux de complications et de ré-hospitalisations dans les 30 jours post-opératoires. Nous avons constaté, après comparaison avec un groupe témoin historique, que l’adhésion au protocole IC a été d’emblée excellente (> 80 %) tout au long de la durée de l’étude. Il n’y a pas eu de modification du taux de ré-hospitalisations et le taux de lâchage de suture a été réduit. Bien que la diminution de la durée de séjour n’était pas l’objectif premier lors de la mise en place de cet IC, elle s’est significativement réduite passant, en moyenne, de 8 à 4 jours. En conclusion, l’introduction d’un IC, pour autant qu’il soit bien préparé et rassemble dans le même objectif l’ensemble des acteurs de soins, est directement bénéfique pour le patient et la qualité de sa prise en charge. [less ▲]

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See detailThree-Dimensional Morphology of the Left Ventricular Outflow Tract: Impact on Grading Aortic Stenosis Severity.
Caballero, Luis; Saura, Daniel; Oliva-Sandoval, Maria Jose et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2017), 30(1), 28-35

BACKGROUND: Left ventricular outflow tract (LVOT) measurement is a critical step in the quantification of aortic valve area. The assumption of a circular morphology of the LVOT may induce some errors. The ... [more ▼]

BACKGROUND: Left ventricular outflow tract (LVOT) measurement is a critical step in the quantification of aortic valve area. The assumption of a circular morphology of the LVOT may induce some errors. The aim of this study was to assess the three-dimensional (3D) morphology of the LVOT and its impact on grading aortic stenosis severity. METHODS: Fifty-eight patients with aortic stenosis were studied retrospectively. LVOT dimensions were measured using 3D transesophageal echocardiography at three levels: at the hinge points (HP) of the aortic valve and at 4 and 8 mm proximal to the annular plane. Results were compared with standard two-dimensional echocardiographic measurements. RESULTS: Three-dimensional transesophageal echocardiography showed a funnel shape that was more circular at the HP and more elliptical at 4 and 8 mm proximal to the annular plane (circularity index = 0.92 vs 0.83 vs 0.76, P < .001). Cross-sectional area was smaller at the HP and larger at 4 and 8 mm from the annular plane (3.6 vs 3.9 vs 4.1 cm2, P = .001). The best correlation between two-dimensional and 3D transesophageal echocardiographic dimensions was at the HP (intraclass correlation coefficient = 0.75; 95% CI, 0.59-0.86). When the HP approach was selected, there was a reduction in the percentage of patients with low flow (from 41% to 29%). CONCLUSIONS: A large portion of patients with aortic stenosis have funnel-shaped and elliptical LVOTs, a morphology that is more pronounced in the region farther from the annular plane. Two-dimensional LVOT measurement closer to the annular plane has the best correlation with 3D measurements. Measurement of the LVOT closer to the annular plane should be encouraged to reduce measurement errors. [less ▲]

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULg; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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See detailEffective components of interventions in juvenile justice facilities: How to take care of delinquent youths?
Mathys, Cécile ULg

in Children and Youth Services Review (2017), 73

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in ... [more ▼]

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in juvenile justice facilities. The effectiveness of remedial measures to best address the sources of youths' delinquent behaviors and the performance of juvenile justice system are discussed first, and then two theoretical frameworks of rehabilitative models are described that are commonly used with delinquent youths. Finally, specific recommendations for enhancing treatment in juvenile justice facilities with regard to the content of interventions, social climate, and youth motivation to engage in treatment are described and explained in a way intended to help caregivers and practitioners, supervisors of juvenile justice facilities, and policy makers improve the daily life of youths placed in this kind of environment. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part II - Imposing Dirichlet boundary conditions
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series ... [more ▼]

This paper focuses on the design of a stable Lagrange multiplier space dedicated to enforce Dirichlet boundary conditions on embedded boundaries of any dimension. It follows a previous paper in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. While the first paper is devoted to the design of a dedicated P1 function space to solve elliptic equations defined on manifolds of codimension one or two (curves in 2D and surfaces in 3D, or curves in 3D), the general treatment of Dirichlet boundary conditions, in such a setting, remains to be addressed. This is the aim of this second paper. A new algorithm is introduced to build a stable Lagrange multiplier space from the traces of the shape functions defined on the background mesh. It is general enough to cover: (i) boundary value problems investigated in the first paper (with, for instance, Dirichlet boundary conditions defined along a line in a 3D mismatching mesh); but also (ii) those posed on manifolds of codimension zero (a domain embedded in a mesh of the same dimension) and already considered in Béchet et al. 2009. In both cases, the compatibility between the Lagrange multiplier space and that of the bulk approximation (the dedicated P1 function space used in (i), or classical shape functions used in (ii)) — resulting in the inf–sup condition — is investigate through the numerical Chapelle-Bath test. Numerical validations are performed against analytical and finite element solutions on problems involving 1D or 2D boundaries embedded in a 2D or 3D background mesh. Comparisons with Nitsche’s method and the stable Lagrange multiplier space proposed in Hautefeuille et al. 2012, when they are feasible, highlight good performance of the approach. [less ▲]

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See detailMetamemory Following Childhood Brain Injury: A Consequence of Executive Impairment
Geurten, Marie ULg; Chevignard, Mathilde; Kerrouche, Bernadette et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2017), 23(1), 67-82

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged ... [more ▼]

In this study, we investigated the influence of children’s level of executive functioning on two types of metamemory knowledge following a traumatic brain injury (TBI). For this purpose, 22 children (aged 7 to 14 years) who had sustained a moderate to severe TBI and 44 typically developing children were recruited. Children with TBI were divided into two groups according to the severity of their executive impairment. Injury severity was determined by the Glasgow Coma Scale (GCS) score on admission or by the duration of unconsciousness. All children were then tested on both their knowledge of general memory functioning and their level of memory self-awareness, respectively assessed using total number of correct responses on an adapted version of Kreutzer et al.’s metamemory interview and a self-other discrepancy score on a questionnaire evaluating everyday memory abilities. Data analyses revealed that participants with TBI who suffered impaired executive functions demonstrated less general metamemory knowledge, and underestimated the frequency of their memory problems, compared with children with TBI who had preserved executive functions and with control participants. Considering the well-established effect of metamemory knowledge on people’s spontaneous implementation of strategies, the interest and the importance of these findings on both theoretical and clinical grounds are discussed. [less ▲]

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See detailPest and mould infestation of smoked shrimp and preventive measures for storage in cottage industry
Kpoclou; Anihouvi; Azokpota et al

in Indian Journal of Traditional Knowledge (2017), 16

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See detailComparison of Indium Tin Oxide and Indium Tungsten Oxide as Transparent Conductive Substrates for WO3-Based Electrochromic Devices
Maho, Anthony ULg; Nicolay, Sylvain; Manceriu, Laura ULg et al

in Journal of the Electrochemical Society (2017), 164(2), 25-31

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See detailFacies discrimination with ERT using a probabilistic methodology: effect of sensitivity and regularization
Hermans, Thomas ULg; Irving, James

in Near Surface Geophysics (2017), 15

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution ... [more ▼]

Electrical resistivity tomography (ERT) has become a standard geophysical method in the field of hydrogeology, as it has the potential to provide important information regarding the spatial distribution of facies. However, inverted ERT images tend to be grossly smoothed versions of reality because of the regularization of the inverse problem. In this study, we use a probabilistic methodology based upon co-located measurements to assess the utility of ERT to identify hydrofacies in alluvial aquifers. With this methodology, ERT images are interpreted in terms of the probability of belonging to pre-defined hydrofacies. We first analyze through a synthetic study the ability of ERT to discriminate between different facies. As ERT data suffer from a loss of sensitivity with depth, we find that low sensitivity regions are more affected by misclassification. To counteract this effect, we adapt the probabilistic framework to include the spatially varying data sensitivity. We then apply our learning to a field case. For the latter, we consider two different regularization procedures. In contrast to the data sensitivity which affects the facies probability to a limited amount, the regularization can affect the probability maps more considerably because it has a strong influence on the spatial distribution of inverted resistivity. We find that a regularization strategy based on the most realistic prior information tends to offer the most reliable discrimination of facies. Our results confirm the ability of ERT surveys, when properly designed, to detect facies variations in alluvial aquifers. The method can be easily extended to other contexts. [less ▲]

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See detailAssessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017)

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both ... [more ▼]

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter- and intramolecular strategies imply the telescoping of multiple processing steps and the generation of unstable diazo species under continuous-flow conditions. The intermolecular strategy relies on an unprecedented continuous-flow Rh-catalyzed intermolecular C–H carbene insertion, providing enriched threo-N-Boc methylphenidate in 38% or 19% isolated yield according to sequential or fully telescoped processes, respectively. Quantitative Boc-deprotection is carried out off-line. The intramolecular strategy relies on a continuous-flow thermal intramolecular C–H carbene insertion, providing enriched threo-methylphenidate hydrochloride in 70% isolated yield. A continuous-flow photochemical alternative is also presented. The critical step of the most promising intramolecular strategy is implemented on the mesoscale in a pilot-scale continuous-flow reactor. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2017), 11

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See detailIconic virtues of diagrams. Peirce on ampliative reasoning
Leclercq, Bruno ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailCardiopulmonary exercise testing is a better outcome predictor than exercise echocardiography in asymptomatic aortic stenosis.
Domanski, Olivia; Richardson, Marjorie; Coisne, Augustin et al

in International Journal of Cardiology (2017), 227

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship ... [more ▼]

BACKGROUND: Objective assessment of maximal aerobic capacity using peak oxygen consumption (peak VO2) can be helpful in the management of patients with asymptomatic aortic stenosis (AS). The relationship between peak VO2 and AS severity criteria derived from rest and supine exercise echocardiography (SEE) has never been explored. OBJECTIVES: We aimed to determine whether low peak VO2 (<85% of predicted value) is associated with severity parameters in SEE, and poor clinical outcome. METHODS: Fifty one asymptomatic patients (mean age of 54+/-21years) with moderate to severe aortic stenosis (Vmax>3m/s) and left ventricle ejection fraction>50% prospectively underwent resting and SEE and cardiopulmonary exercise testing (CPX). RESULTS: Peak VO2 was lower than expected (21.9+/-7.4mL/kg/min), i.e. <85% of predicted value in 57% patients, secondary to cardiac limitation in most of them (69%). In multiple regression analysis, age, BMI and female gender were the only independent determinants of peak VO2. Interestingly no parameter derived from SEE was associated with peak VO2. After 21+/-7month follow-up, no patient died, 20 underwent cardiac surgery. Peak VO2<85% of predicted value was associated with lower event free survival compared to normal peak VO2 (57%+/-11% vs 93+/-6%, p=0.036) whereas no exercise echocardiographic parameter could predict such events. Peak VO2>/=85% had a negative predictive value of 97%. CONCLUSION: CPX detects a high proportion of false asymptomatic AS patients with poorer outcome that cannot be predicted by SEE markers of AS severity. Assessment of aerobic capacity should be part of current approach within a "watchful waiting" strategy. [less ▲]

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See detailThe use of oxytocin to improve feeding and social skills in infants with Prader-Willi syndrome
Tauber, Maïthé; Boulanouar, Kader; Gwenaelle, Diene et al

in Pediatrics (2017), 139(2),

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 infants in each step) who received 4 IU of OXT either every other day, daily, or twice daily. We investigated the tolerance and the effects on feeding and social skills and changes in circulating ghrelin and brain connectivity by functional MRI. RESULTS: No adverse events were reported. No dose effect was observed. Sucking assessed by the Neonatal Oral-Motor Scale was abnormal in all infants at baseline and normalized in 88% after treatment. The scores of Neonatal Oral-Motor Scale and videofluoroscopy of swallowing significantly decreased from 16 to 9 (P < .001) and from 18 to 12.5 (P < .001), respectively. Significant improvements in Clinical Global Impression scale scores, social withdrawal behavior, and mother–infant interactions were observed. We documented a significant increase in acylated ghrelin and connectivity of the right superior orbitofrontal network that correlated with changes in sucking and behavior. CONCLUSIONS: OXT is well tolerated in infants with PWS and improves feeding and social skills. These results open perspectives for early treatment in neurodevelopment diseases with feeding problems. [less ▲]

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See detailThe global burden of chronic kidney disease: estimates, variability and pitfalls.
Glassock, RJ; Warnock, DG; DELANAYE, Pierre ULg

in Nature Reviews Nephrology (2017), 13(2), 104-114

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See detailThe lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation
Sayyed, Sufyan Ali ULg; JOURET, François ULg; Vermeersch, Marjorie et al

in Kidney International (2017)

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body ... [more ▼]

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knock-out mice, proximal tubule-specific Ship2 knock-out mice and a proximal tubule cell model where SHIP2 is inactivated, we show that SHIP2 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule. We found increased PtdIns(4,5)P2 substrate and decreased PtdIns4P product when SHIP2 was inactivated, associated with hyperactivated Ezrin/Radixin/Moesin proteins and increased Rho-GTP. Thus, inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule. This may represent an innovative therapeutic target for renal Fanconi syndromes characterized by decreased reabsorption of solutes by this nephron segment. [less ▲]

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See detailMars Topography Investigated Through the Wavelet Leaders Method: a Multidimensional Study of its Fractal Structure
Deliège, Adrien ULg; Kleyntssens, Thomas ULg; Nicolay, Samuel ULg

in Planetary and Space Science (2017), 136C

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based ... [more ▼]

This work examines the scaling properties of Mars topography through a wavelet-based formalism. We conduct exhaustive one-dimensional (both longitudinal and latitudinal) and two-dimensional studies based on Mars Orbiter Laser Altimeter (MOLA) data using the multifractal formalism called Wavelet Leaders Method (WLM). This approach shows that a scale break occurs at approximately 15 km, giving two scaling regimes in both 1D and 2D cases. At small scales, these topographic profiles mostly display a monofractal behavior while a switch to multifractality is observed in several areas at larger scales. The scaling exponents extracted from this framework tend to be greater at small scales. In the 1D context, these observations are in agreement with previous works and thus suggest that the WLM is well-suited for examining scaling properties of topographic fields. Moreover, the 2D analysis is the first such complete study to our knowledge. It gives both a local and global insight on the scaling regimes of the surface of Mars and allows to exhibit the link between the scaling exponents and several famous features of the Martian topography. These results may be used as a solid basis for further investigations of the scaling laws of the Red planet and show that the WLM could be used to perform systematic analyses of the surface roughness of other celestial bodies. [less ▲]

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See detailA test field for Gaia. Radial velocity catalogue of stars in the South Ecliptic Pole
Frémat, Y.; Altmann, M.; Pancino, E. et al

in Astronomy and Astrophysics (2017), 597

Context. Gaia is a space mission that is currently measuring the five astrometric parameters, as well as spectrophotometry of at least 1 billion stars to G = 20.7 mag with unprecedented precision. The ... [more ▼]

Context. Gaia is a space mission that is currently measuring the five astrometric parameters, as well as spectrophotometry of at least 1 billion stars to G = 20.7 mag with unprecedented precision. The sixth parameter in phase space (i.e., radial velocity) is also measured thanks to medium-resolution spectroscopy that is being obtained for the 150 million brightest stars. During the commissioning phase, two fields, one around each ecliptic pole, have been repeatedly observed to assess and to improve the overall satellite performances, as well as the associated reduction and analysis software. A ground-based photometric and spectroscopic survey was therefore initiated in 2007, and is still running to gather as much information as possible about the stars in these fields. This work is of particular interest to the validation of the radial velocity spectrometer outputs. <BR /> Aims: The paper presents the radial velocity measurements performed for the Southern targets in the 12-17 R magnitude range on high- to mid-resolution spectra obtained with the GIRAFFE and UVES spectrographs. <BR /> Methods: Comparison of the South Ecliptic Pole (SEP) GIRAFFE data to spectroscopic templates observed with the HERMES (Mercator in La Palma, Spain) spectrograph enabled a first coarse characterisation of the 747 SEP targets. Radial velocities were then obtained by comparing the results of three different methods. <BR /> Results: In this paper, we present an initial overview of the targets to be found in the 1 sq. deg SEP region that was observed repeatedly by Gaia ever since its commissioning. In our representative sample, we identified one galaxy, six LMC S-stars, nine candidate chromospherically active stars, and confirmed the status of 18 LMC Carbon stars. A careful study of the 3471 epoch radial velocity measurements led us to identify 145 RV constant stars with radial velocities varying by less than 1 km s[SUP]-1[/SUP]. Seventy-eight stars show significant RV scatter, while nine stars show a composite spectrum. As expected, the distribution of the RVs exhibits two main peaks that correspond to Galactic and LMC stars. By combining [Fe/H] and log g estimates, and RV determinations, we identified 203 members of the LMC, while 51 more stars are candidate members. <BR /> Conclusions: This is the first systematic spectroscopic characterisation of faint stars located in the SEP field. During the coming years, we plan to continue our survey and gather additional high- and mid-resolution data to better constrain our knowledge on key reference targets for Gaia. Tables 1-3, 5, 7, and 8 are only available at the CDS via anonym- ous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/597/A10">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/597/A10</A>Based on data taken with the VLT-UT2 of the European Southern Observatory, programmes 084.D-0427(A), 086.D-0295(A), and 088.D-0305(A).Based on data obtained from the ESO Science Archive Facility under request number 84886.Based on data obtained with the HERMES spectrograph, installed at the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias and supported by the Fund for Scientific Research of Flanders (FWO), Belgium, the Research Council of KU Leuven, Belgium, the Fonds National de la Recherche Scientifique (F.R.S.-FNRS), Belgium, the Royal Observatory of Belgium, the Observatoire de Genève, Switzerland and the Thüringer Landessternwarte Tautenburg, Germany. [less ▲]

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See detailPest regulation and support of natural enemies in agriculture: Experimental evidence of within field wildflower strips
Hatt, Séverin ULg; Chevalier Mendes Lopes, Thomas ULg; Boeraeve, Fanny ULg et al

in Ecological Engineering (2017), 98

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for ... [more ▼]

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for today’sagriculture. The aim of this study was to assess whether the two strategies of complicating the search ofhost plants by pests by increasing plant diversity, and of supporting their natural enemies by managinghabitats, could be combined simultaneously at the field scale to restore biological pest control and reducechemical insecticide use. In Gembloux (Belgium), wildflower strips (WFS) were sown within wheat cropsin which pests (i.e., aphids), their predators (i.e. aphidophagous hoverflies, lacewings and ladybeetles)and parasitoid wasps were monitored for 10 weeks in the period of May through July 2015 as indicatorsof the ES of pest control. Aphids were significantly reduced and adult hoverflies favoured in wheat inbetween WFS, compared to monoculture wheat plots. No significant differences were observed for adultlacewings, ladybeetles and parasitoids. In all treatments, very few lacewing and ladybeetle larvae wereobserved on wheat tillers. The abundance of hoverfly larvae was positively correlated with the aphid den-sity on tillers in between WFS, showing that increasing food provisions by multiplying habitats withinfields, and not only along margins, can help supporting aphidophagous hoverflies in crops. By enhancingthe ecosystem services of biological pest control, this study shows that increasing both plant diversityand managing habitats for natural enemies may reduce aphid populations, hence insecticide use. Futureresearch should continue this vein of work by quantifying the link between agricultural practices and thedelivery of ecosystem services in order to guide future measures of agricultural policies. [less ▲]

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See detailA new, challenging benchmark for nonlinear system identification
Tiso, Paolo; Noël, Jean-Philippe ULg

in Mechanical Systems & Signal Processing (2017), 84

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by ... [more ▼]

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by challenging the community through a new benchmark structure exhibiting complex nonlinear dynamics. The proposed structure consists of two o ffset cantilevered beams connected by a highly flexible element. For increasing forcing amplitudes, the system sequentially features linear behaviour, localised nonlinearity associated with the buckling of the connecting element, and distributed nonlinearity resulting from large elastic deformations across the structure. A finite element-based code with time integration capabilities is made available at http://sem.org/TDIV-Nonlin.asp. This code permits the numerical simulation of the benchmark dynamics in response to arbitrary excitation signals. [less ▲]

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See detailGenomic Studies of Multiple Myeloma Reveal an Association between X Chromosome Alterations and Genomic Profile Complexity.
Sticca, Tiberio ULg; CABERG, Jean-Hubert ULg; Wenric, Stéphane ULg et al

in Genes, Chromosomes & Cancer (2017)

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH ... [more ▼]

The genomic profile of multiple myeloma (MM) has prognostic value by dividing patients into a good prognosis hyperdiploid group and a bad prognosis non-hyperdiploid group with a higher incidence of IgH translocations. This classification, however, is inadequate and many other parameters like mutations, epigenetic modifications and genomic heterogeneity may influence the prognosis. We performed a genomic study by array-based comparative genomic hybridization (aCGH) on a cohort of 162 patients to evaluate the frequency of genomic gains and losses. We identified a high frequency of X chromosome alterations leading to partial Xq duplication, often associated with Xi deletion in female patients. This partial X duplication could be a cytogenetic marker of aneuploidy as it is correlated with a high number of chromosomal breakages. Patient with high level of chromosomal breakage had reduced survival regardless the region implicated. A higher transcriptional level was shown for genes with potential implication in cancer and located in this altered region. Among these genes, IKBKG and IRAK1 are members of the NFKB pathway which plays an important role in MM and is a target for specific treatments. [less ▲]

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See detailEmployee perspectives on safety citizenship behaviors and safety violations
Chmiel, Nik; Laurent, Julie ULg; Hansez, Isabelle ULg

in Safety Science (2017), 93

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two ... [more ▼]

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two types of safety violation: routine violations conceptualized as related to an individual’s available cognitive energy or ‘effort’; and situational violations, which are those provoked by the organization (Reason, 1990). Study 1 showed SCRDs predicted situational violations only, and partially mediated the relationships between Perceived Management Commitment to Safety (PMCS) and work engagement with situational violations. These findings add to those by Hansez and Chmiel (2010), showing that routine and situational violations have predictors that differ. Study 1 findings also extend research reported by Turner et al. (2005), by showing that the effect of Job Control on SCRDs was mediated by both PMCS and work engagement. In study 2, participation in discretionary safety activities (safety participation) mediated the relationship between SCRDs and situational violations. Similar to study 1 The link between SCRDs and routine violations was non-significant and, strikingly, so was the link between safety participation and routine violations. These results support the view that processes involving SCRDs and safety participation are not cognitive-energetical in nature. In addition, study 2 findings extend previous work by Neal and Griffin (2006) by showing that SCRDs and safety knowledge partially mediated relationships between safety motivation and safety participation, whereas the direct effect of safety motivation on safety participation was non-significant. The results from both studies support the view that SCRDs are important in predicting situational violations. In study 2 SCRDs were shown to partially mediate the relationship between safety motivation and selfreported participation in discretionary safety activities (Safety Participation) which, in turn, related to situational violations. Interestingly there was no significant direct link between SCRDs and situational violations. These findings support the view that the effect of SCRDs on situational violations is fully mediated by participation in discretionary safety activities. [less ▲]

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See detailSimilarity of the Jovian satellite footprints: spots multiplicity and dynamics
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, S. V. et al

in Icarus (2017)

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the ... [more ▼]

In the magnetospheres of Jupiter and Saturn, the intense interaction of the satellites Io, Europa, Ganymede and Enceladus with their surrounding plasma environment leaves a signature in the aurora of the planet. Called satellite footprints, these auroral features appear either as a single spot (Europa and Enceladus) or as multiple spots (Io and Ganymede). Moreover, they can be followed by extended trailing tails in the case of Io and Europa, while no tail has been reported for Ganymede and Enceladus, yet. Here we show that all Jovian footprints can be made of several spots. Furthermore, the footprints all experience brightness variations on timescale of 2-3 minutes. We also demonstrate that the satellite location relative to the plasma sheet is not the only driver for the footprint brightness, but that the plasma environment and the magnetic field strength also play a role. These new findings demonstrate that the Europa and Ganymede footprints are very similar to the Io footprint. As a consequence, the processes expected to take place at Io, such as the bi-directional electron acceleration by Alfvén waves or the partial reflection of these waves on plasma density gradients, can most likely be extended to the other footprints, suggesting that they are indeed universal processes. [less ▲]

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See detailThe Tourist on the farm: a 'muddled' image
Dubois, Charline ULg; Cawley, Mary; Schmitz, Serge ULg

in Tourism Management (2017), 59

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better ... [more ▼]

Agritourism is promoted as a method of offsetting decline in farm incomes, and is defined in different ways which creates difficulties in attracting tourists. The present research contributes to a better understanding of agritourism, based on evidence in Wallonia (Belgium) and Luxembourg. It does so by studying the image held by four groups of actors: (i) farmers who provide ‘agritourist’ experiences; (ii) promotional organisations; and tourists who both (iii) have and (iv) have not engaged in agritourism. Agritourism is a muddled concept between realities and stakeholder expectations but opportunities exist for targeting particular niche interests. [less ▲]

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See detailDiet effects on bumblebee health
Roger, N.; Michez, D.; Wattiez, R. et al

in Journal of Insect Physiology (2017), 96

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as ... [more ▼]

Among physiological processes, the maintenance of immunity is one of the most energetically costly in invertebrates. Disease resistance can be quantified by measuring immunocompetence, which is defined as the ability of an organism to mount an immune response, either in cellular, humoral or behavioural forms. In insects, immune capacity can be affected by a variety of factors including pesticides, genetic diversity or diet. Here we focus on an important species of domesticated pollinator, Bombus terrestris, and the potential impact of a poor pollen diet (low nutritional content and toxic) on its health. We investigate three responses at both colony and individual levels: behavioural, humoral and cellular. Our results show that poor pollen diets decrease larval and pupal masses and increase larval ejection as well as adult constitutive immunity (i.e., prophenoloxidase assays). The susceptibility of bumblebees to disease and infection might therefore be greater after a nutritive stress. These findings raise the importance of available plant hosts, especially floral plant species providing pollen with suitable nutritive quality (i.e., nutrient pollen content) for bumblebees. © 2016 Elsevier Ltd [less ▲]

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See detailA dynamic, sex-specific expression pattern of genes regulating thyroid hormone action in the developing zebra finch song control system
Raymaekers, S.R.; Verbeure, W.; Ter Haar, S.M. et al

in General and Comparative Endocrinology (2017), 240

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel ... [more ▼]

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel- lent model to study developmental neuroplasticity. Despite the demonstrated influence of hormones such as sex steroids on this phenomenon, thyroid hormones (THs) – an important factor in neural devel- opment and maturation – have not been studied in this regard. We used in situ hybridization to compare the expression of TH transporters, deiodinases and receptors between both sexes during all phases of song development in male zebra finch. Comparisons were made in four song control nuclei: Area X, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), HVC (used as proper name) and the robust nucleus of the arcopallium (RA). Most genes regulating TH action are expressed in these four nuclei at early stages of development. However, while general expression levels decrease with age, the activating enzyme deiodinase type 2 remains highly expressed in Area X, HVC and RA in males, but not in females, until 90days post-hatch (dph), which marks the end of sensorimotor learning. Furthermore, the L-type amino acid transporter 1 and TH receptor beta show elevated expression in male HVC and RA respectively compared to surrounding tissue until adulthood. Differences compared to sur- rounding tissue and between sexes for the other TH regulators were minor. These developmental changes are accompanied by a strong local increase in vascularization in the male RA between 20 and 30 dph but not in Area X or HVC. Our results suggest that local regulation of TH signaling is an important factor in the development of the song control nuclei during the song learning phase and that TH activation by DIO2 is a key player in this process. [less ▲]

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See detailEvaluation of hazardous chemicals in edible insects and insect-based food intended for human consumption
Poma, G; Cuykx, M; Amato, E et al

in Food and Chemical Toxicology (2017), 100

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See detailLa géographie linguistique au nord du domaine d'oïl
Baiwir, Esther ULg

in Bien Dire et Bien Aprandre : Bulletin du Centre d'Etudes Médiévales et Dialectales de l'Université de Lille III (2017), 32

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See detailEstrogen receptors and estetroldependent neuroprotective actions: a pilot study
Tskitishvili, Ekaterine ULg; Pequeux, Christel ULg; Munaut, Carine ULg et al

in Journal of Endocrinology (2017), 232(1), 85-95

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic–ischemic encephalopathy. We aimed to define the role of estrogen ... [more ▼]

Estetrol (E4) has strong antioxidative, neurogenic and angiogenic effects in neural system resulting in the attenuation of neonatal hypoxic–ischemic encephalopathy. We aimed to define the role of estrogen receptors in E4-dependent actions in neuronal cell cultures and prove the promyelinating effect of E4. In vitro the antioxidative and cell survival/ proliferating effects of E4 on H2O2-induced oxidative stress in primary hippocampal cell cultures were studied using different combinations of specific inhibitors for ERα (MPP dihydrochloride), ERβ (PHTTP), GPR30 (G15) and palmytoilation (2-BR). LDH activity and cell survival assays were performed. In vivo the promyelinating role of different concentrations of E4 (1mg/kg/day, 5mg/kg/day, 10mg/kg/day, 50mg/kg/day) was investigated using the hypoxic–ischemic brain damage model in the 7-day-old immature rats before/after the induction of hypoxic–ischemic insult. Myelin basic protein (MBP) immunostaining was performed on brain coronal sections. Our results show that LDH activity is significantly upregulated in cell cultures where the E4’s effect was completely blocked by concomitant treatment either with ERα and ERβ inhibitors (MPP and PHTPP, respectively), or ERα and ERβ inhibitors combined with 2-BR. Cell survival is significantly downregulated in cell cultures where the effect of E4 was blocked by ERβ inhibitor (PHTTP) alone. The blockage of GRP30 receptor did affect neither LDH activity nor cell survival. MBP immunostaining is significantly upregulated in E4-pretreated groups at a concentration of 5mg/kg/day and 50mg/kg/day E4, whereas the MBP-positive area OD ratio is significantly increased in all the E4-treated groups. E4’s antioxidative actions mostly depend on ERα and ERβ, whereas neurogenesis and possibly promyelinating activities might be realized through ERβ. [less ▲]

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See detailSampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study
Thiry, Justine ULg; Evrard, Brigitte ULg; Nys, Gwenaël ULg et al

in Journal of Chromatography. A (2017), 1479

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to ... [more ▼]

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to collect small quantities (10 or 20 µL) of whole blood, thereby limiting the amount of animals needed. In this study, a quantitative method was developed and subsequently validated for the poorly soluble drug itraconazole (ITZ) using VAMS and ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS). A proof of concept study showed that the optimized method is applicable to test the bioavailability of drug formulations containing ITZ. Using VAMS, smaller blood volumes can be taken per sampling point (10-20 µL instead of the conventional 0.2-0.5 mL) avoiding the sacrifice of animals. Moreover, the same rats can be used to compare different drug formulations which strengthens the validity of the results. In long-term bioavailability studies, it is necessary to guarantee the stability of the tested drugs supported on VAMS devices. In this study, we show that ITZ was only stable for 24 hours after collection with VAMS, but for at least two weeks by the storage of extracted samples at -80°C. [less ▲]

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See detailMembrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group
Geudens, Niels; Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg et al

in Biochimica et Biophysica Acta - Biomembranes (2017), 1859(3), 331-339

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It ... [more ▼]

Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane is central to the mode of action of CLPs. In this work, we focus on the CLPs of the so-called viscosin group, aiming to assess the impact of the main structural variations observed within this group on both the antimicrobial activity and the interaction with model membranes. The antimicrobial activity of viscosin, viscosinamide A, WLIP and pseudodesmin A were all tested on a broad panel of mainly Gram-positive bacteria. Their capacity to permeabilize or fuse PG/PE/cardiolipin model membrane vesicles is assessed using fluorescent probes. We find that the Glu2/Gln2 structural variation within the viscosin group is the main factor that influences both the membrane permeabilization properties and the minimum inhibitory concentration of bacterial growth, while the configuration of the Leu5 residue has no apparent effect. The CLPmembrane interactions were further evaluated using CD and FT-IR spectroscopy on model membranes consisting of PG/PE/cardiolipin or POPC with or without cholesterol. In contrast to previous studies, we observe no conformational change upon membrane insertion. The CLPs interact both with the polar heads and aliphatic tails of model membrane systems, altering bilayer fluidity, while cholesterol reduces CLP insertion depth [less ▲]

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See detailExome copy number variation detection: Use of a pool of unrelated healthy tissue as reference sample
Wenric, Stéphane ULg; Sticca, Tiberio ULg; CABERG, Jean-Hubert ULg et al

in Genetic Epidemiology (2017)

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been ... [more ▼]

An increasing number of bioinformatic tools designed to detect CNVs (copy number variants) in tumor samples based on paired exome data where a matched healthy tissue constitutes the reference have been published in the recent years. The idea of using a pool of unrelated healthy DNA as reference has previously been formulated but not thoroughly validated. As of today, the gold standard for CNV calling is still aCGH but there is an increasing interest in detecting CNVs by exome sequencing. We propose to design a metric allowing the comparison of two CNV profiles, independently of the technique used and assessed the validity of using a pool of unrelated healthy DNA instead of a matched healthy tissue as reference in exome-based CNV detection. We compared the CNV profiles obtained with three different approaches (aCGH, exome sequencing with a matched healthy tissue as reference, exome sequencing with a pool of eight unrelated healthy tissue as reference) on three multiple myeloma samples. We show that the usual analyses performed to compare CNV profiles (deletion/amplification ratios and CNV size distribution) lack in precision when confronted with low LRR values, as they only consider the binary status of each CNV. We show that the metric-based distance constitutes a more accurate comparison of two CNV profiles. Based on these analyses, we conclude that a reliable picture of CNV alterations in multiple myeloma samples can be obtained from whole-exome sequencing in the absence of a matched healthy sample. [less ▲]

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See detailOn the evaluation of interface quality in concrete repair system by means of impact-echo signal analysis
Garbacz, Andrzej; Piotrowski, Tomacz; Courard, Luc ULg et al

in Construction and Building Materials (2017), 134

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The ... [more ▼]

According to Concrete Repair Manual as well as ACI 562-16 and European EN 1504-10 standards, a bond strength as a measure of adhesion is one the main feature of repair system necessary to be assessed. The most common laboratory and engineering method for bond strength evaluation is pull-off test. This is however a semi-destructive method that needs a repair in a place of measurement. Recently, the great interest in nondestructive techniques (NDT) development is noted. Impact-Echo (IE) is considered as one of the most promising methods for this purpose. In this paper, the study on the usability the IE test based on frequency spectrum analysis for bond strength evaluation is analyzed. Both Finite Element Method (FEM) simulation and experimental tests were performed in order to obtain potential relations between IE frequency spectrum and parameters characterizing concrete substrate quality that may affect the final bond strength and the real value of pull-off bond strength measured on samples as well. It was concluded that the IE method can be a useful tool for interface quality and bond strength evaluations in concrete repair system. However, more complex signal analysis, e.g. wavelet analysis, should be considered in the future. [less ▲]

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See detailL’ÉVALUATION DES POLITIQUES PUBLIQUES DANS LE CHAMP DE LA COOPÉRATION AU DÉVELOPPEMENT BELGE : LE CAS DU SERVICE DE L’ÉVALUATION SPÉCIALE
Contor, Justine ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017)

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation ... [more ▼]

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation Spéciale de la coopération belge au développement (SES). Nous présenterons dans ce document les raisons de la création de ce service au début des années 2000. En effet, le SES, avec d’autres acteurs, est le résultat d’une grande réforme de la coopération issue d’une lourde crise. Nous reviendrons sur son mandat, sur ses spécificités organisationnelles (ressources financières et humaines) ainsi que son cadre de référence normatif. La question de la culture évaluative sera questionnée, ainsi que son lien avec l’émergence du New Public Management dans la politique de coopération au développement. Enfin, nous questionnerons la légitimité d’une structure telle que le SES au regard d’un cadrage théorique mixte (Scott, 1995 ; Suchmann, 1995) et de la théorie des parties prenantes. [less ▲]

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See detailCan DEM time series produced by UAV be used to quantify diffuse erosion in an agricultural watershed?
Pineux, Nathalie ULg; Lisein, Jonathan ULg; Swerts, Gilles ULg et al

in Geomorphology (2017), 280

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion ... [more ▼]

Erosion and deposition modelling should rely on field data. Currently these data are seldom available at large spatial scales and/or at high spatial resolution. In addition, conventional erosion monitoring approaches are labour intensive and costly. This calls for the development of new approaches for field erosion data acquisition. As a result of rapid technological developments and low cost, unmanned aerial vehicles (UAV) have recently become an attractive means of generating high resolution digital elevation models (DEMs). The use of UAV to observe and quantify gully erosion is now widely established. However, in some agro-pedological contexts, soil erosion results from multiple processes, including sheet and rill erosion, tillage erosion and erosion due to harvest of root crops. These diffuse erosion processes often represent a particular challenge because of the limited elevation changes they induce. In this study,we propose to assess the reliability and development perspectives of UAV to locate and quantify erosion and deposition in a context of an agricultural watershed with silt loam soils and a smooth relief. Erosion and deposition rates derived from high resolution DEM time series are compared to field measurements. The UAV technique demonstrates a high level of flexibility and can be used, for instance, after a major erosive event. It delivers a very high resolution DEM(pixel size: 6 cm) which allows us to compute high resolution runoff pathways. This could enable us to precisely locate runoff management practices such as fascines. Furthermore, the DEMs can be used diachronically to extract elevation differences before and after a strongly erosive rainfall and be validated by field measurements. While the analysis for this study was carried out over 2 years, we observed a tendency along the slope from erosion to deposition. Erosion and deposition patterns detected at the watershed scale are also promising. Nevertheless, further development in the processing workflow of UAV data is required in order to make this technique accurate and robust enough for detecting sediment movements in an agricultural watershed affected by diffuse erosion. This area of investigation holdsmuch potential as the images processing is relatively new and expanding. [less ▲]

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See detailOptimized approach to retrieve information on atmospheric carbonyl sulfide (OCS) above the Jungfraujoch station and change in its abundance since 1995
Lejeune, Bernard ULg; Mahieu, Emmanuel ULg; Vollmer, M. K. et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2017), 186

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss ... [more ▼]

In this paper, we present an optimized retrieval strategy for carbonyl sulfide (OCS), using Fourier transform infrared (FTIR) solar observations made at the high-altitude Jungfraujoch station in the Swiss Alps. More than 200 lines of the nu3 fundamental band of OCS have been systematically evaluated and we selected 4 microwindows on the basis of objective criteria minimizing the effect of interferences, mainly by solar features, carbon dioxide and water vapor absorption lines, while maximizing the information content. Implementation of this new retrieval strategy provided an extended time series of the OCS abundance spanning the 1995-2015 time period, for the study of the long-term trend and seasonal variation of OCS in the free troposphere and stratosphere. Three distinct periods characterize the evolution of the tropospheric partial columns: a first decreasing period (1995-2002), an intermediate increasing period (2002-2008), and the more recent period (2008-2015) which shows no significant trend. Our FTIR tropospheric and stratospheric time series are compared with new in situ gas chromatography mass spectrometry (GCMS) measurements performed by Empa (Laboratory for Air Pollution/Environmental Technology) at the Jungfraujoch since 2008, and with space-borne solar occultation observations by the ACE-FTS instrument on-board the SCISAT satellite, respectively, and they show good agreement. The OCS signal recorded above Jungfraujoch appears to be closely related to anthropogenic sulfur emissions. [less ▲]

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See detailExtreme intra-clutch egg size dimorphism is not coupled with corresponding differences in antioxidant capacity and stable isotopes between eggs
Poisbleau, Maud; Beaulieu, Michaël; Dehnhard, Nina et al

in Comparative Biochemistry and Physiology Part A : Molecular & Integrative Physiology (2017), 205

Oviparous females need to allocate resources optimally to their eggs in order to maximize their fitness. Among these resources, dietary antioxidants, acquired by females and transferred to the eggs during ... [more ▼]

Oviparous females need to allocate resources optimally to their eggs in order to maximize their fitness. Among these resources, dietary antioxidants, acquired by females and transferred to the eggs during egg formation, can greatly affect the development and survival of the embryo and chick. In crested penguins, incubation starts after the second and last egg is laid and, as opposed to many other bird species, this egg hatches first, thereby enhancing the survival of the chick. Here, we assessed whether antioxidant and isotopic composition could underlie these differences between eggs within clutches of southern rockhopper penguins (Eudyptes chrysocome chrysocome). The second-laid egg had higher total antioxidant capacity than the first-laid egg, although this was not due to higher antioxidant concentration but to its higher mass. This suggests that resources are allocated by females at a constant rate in both eggs within clutches. Accordingly, we found a strong correlation for isotopic compositions between eggs suggesting that resources were allocated similarly to each egg within the clutch. Overall, we found little evidence for a significant role of antioxidant and isotopic compositions to explain differences in terms of embryo/chick development between eggs in crested penguins. However, since our results suggest a constant rate of antioxidant transfer from females to eggs, limiting the mass of the first-laid egg might represent a strategy for females to spare antioxidant defences and preserve self-maintenance. [less ▲]

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See detailCaryl Phillips’s The Lost Child: A Story of Loss and Connection
Ledent, Bénédicte ULg; O'Callaghan, Evelyn

in Ariel : A Review of International English Literature (2017)

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See detailAdministrative Change in the EU: a Cross-Country Empirical Study on the Contextual Determinants of NPM Reform Rhetoric
Esposito, Giovanni ULg; Gaeta, Giuseppe Lucio; Trasciani, Giorgia

in Annals of Public and Cooperative Economics (2017)

Framed within the paradigm of New Public Management (NPM), structural reforms in the EU aimed at modernizing the public administrations of Member States (MSs) have long since been a priority area of the ... [more ▼]

Framed within the paradigm of New Public Management (NPM), structural reforms in the EU aimed at modernizing the public administrations of Member States (MSs) have long since been a priority area of the EU’s economic policy. Since the 1990s, these reforms have been sharply intensified across European countries with the declared purpose of enhancing economy, efficiency and effectiveness in their national public sectors’ organizations. In line with the European Commission’s recent research initiatives in search for novel quantitative data on NPM in the EU, this paper studies European parties’ NPM reform rhetoric. More specifically, it investigates the MSs’ institutional, economic and political context within which parties have declared their intention of reforming national administrative systems. Thus, it sheds light on the MSs’ domestic factors that are associated with the diffusion of the NPM values across the political discourse of EU’s national parties. [less ▲]

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See detailComputerized adaptive testing with R: Recent updates of the package catR
Magis, David ULg; Barrada, Juan Ramon

in Journal of Statistical Software (2017), 76(1), 1-19

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying ... [more ▼]

The purpose of this paper is to list the recent updates of the R package catR. This package allows for generating response patterns under a computerized adaptive testing (CAT) framework with underlying item response theory (IRT) models. Among the most important updates, well-known polytomous IRT models are now supported by catR; several item selection rules have been added; and it is now possible to perform post-hoc simulations. Some functions were also rewritten or withdrawn to improve the usefulness and performances of the package. [less ▲]

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See detailLa « personnalité antisociale », antithèse de la psychopathologie
Englebert, Jérôme ULg; Adam, Christophe

in Déviance et Société (2017), 41(1),

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au ... [more ▼]

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au sein du système de justice pénale. Notre réflexion débutera par une généalogie du vocable dans différentes versions de la classification psychiatrique, depuis les années cinquante jusqu’aujourd’hui, et plus particulièrement celle faisant autorité du Manuel statistique et diagnostique des troubles mentaux (DSM). L’absence de raisonnement sociologique dans l’usage d’une notion impliquant pourtant la référence au « social » sera discutée ainsi que ses évolutions historiques. Ensuite, la démonstration de l’antithèse que cette notion constitue pour une perspective psychopathologique digne de ce nom – dynamique, compréhensive et phénoménologique – sera développée en six arguments majeurs et plurivoques, tantôt empiriques et cliniques, tantôt théoriques. [less ▲]

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See detailAn Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; De Zanet, Fabrice ULg et al

in Journal of Service Management (2017), 28

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them ... [more ▼]

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative customer emotions and customer satisfaction with employee response in ECSEs. Design/methodology—This study relies on a video-based experiment that depicts a customer involved in an ECSE as a service provider delivers bad news to him. The hypothesis tests use a two-way independent analysis of covariance. Results—Both emotional and technical competencies must be displayed to improve the customer experience in an ECSE. When EEC is low, ETC does not decrease negative customer emotions or increase customer satisfaction with employee response. When EEC is high, ETC instead has a significant impact on both customer outcomes. Practical implications—Managers must train employees to develop both technical and emotional competencies. Employees who demonstrate only one type cannot temper customers’ emotions or enhance their perceptions of the employees’ response as well as can those strong in both competencies. Originality/value—Using a video-based experiment, this study examines the moderating role of EEC in the relationship between ETC and two key aspects of the customer experience in an ECSE (negative customer emotions and customer satisfaction with employee responses) following the delivery of bad news. [less ▲]

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See detailEmbedded solids of any dimension in the X-FEM. Part I - Building a dedicated P1 function space
Duboeuf, Frédéric ULg; Béchet, Eric ULg

in Finite Elements in Analysis and Design (2017)

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape ... [more ▼]

This paper focuses on the design of a dedicated P1 function space to model elliptic boundary value problem on a manifold embedded in a space of higher dimension. Using the traces of the linear P1 shape functions, it introduces an algorithm to reduce the function space into an equivalent space having the same properties than a P1 Lagrange approximation. Convergence studies involving problems of codimension one or two embedded in 2D or 3D show good accuracy with regard to classical finite element and analytical solutions. The effects of the relative position of the domain with respect to the mesh are studied in a sensitivity analysis; it illustrates how the proposed solution allows to keep the condition number bounded. A comparative study is performed with the method introduced by Olshanskii et al. 2009 on a closed surface to validate our approach. The robustness of the proposed approach is investigated with regard to their method and that of Burman et al. 2016. This paper is the first in a series of two, on the topic of embedded solids of any dimension within the context of the extended finite element method. It investigates problems involving borderless domains or domains with boundary subject to Dirichlet constraint defined only on the boundaries of the bulk mesh, while the forthcoming paper overcomes this limitation by introducing a new stable Lagrange multiplier space for Dirichlet boundary condition (and more generally stiff condition), that is valid for every combination of the background mesh and manifold dimensions. The combination of both algorithms allows to handle any embedding i.e. 1D, 2D and 3D problems embedded in 2D or 3D background meshes. [less ▲]

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2017), 7

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See detailImpaired familiarity in individuals at risk for Alzheimer's disease: Commentary on Schoemaker et al. (2016)
Bastin, Christine ULg; Besson, Gabriel ULg

in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017), 6

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See detailSeasonal characterization of the nutrients state in Oualidia Lagoon (Moroccan Atlantic coast)
Damsiri, Zainab; Natij, L.; Khalil, Karima et al

in Journal of Materials and Environmental Science (2017), 8(1), 67-77

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at ... [more ▼]

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at high tide from March to August during years 2011 and 2012 at six stations distributed throughout the lagoon. The physico- chemistry (temperature, salinity, dissolved O2) and nutrient enrichment of the lagoon surface water were monitored. The average nutrient concentration of surface water were 14.4 μmol.l-1 and 28.1 μmol.l-1 for NH4+, 20.4 μmol.l-1 and 19.9 μmol.l-1 for PO43- and 3.7 μmol.l-1 and 7.6 μmol.l-1 for NO2- in 2011 and 2012, respectively. Strong seasonal differences of nutrient distribution at the different stations were noticed. Temperature, salinity and dissolved O2 were correlated with nutrient concentrations, all parameters showing low spatial (inter-station) variability. Hydrological conditions exert a major control on the nutrient cycling in the lagoon. Results of this study are important to increase the richness on the scientific knowledge of nutrient dynamics along the Moroccan Atlantic coast, particularly in the semi-enclosed lagoons that are important transitional systems. [less ▲]

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See detailStudy of the photocatalytic activity of Fe3+, Cr3+, La3+ and Eu3+ single-doped and co-doped TiO2 catalysts produced by aqueous sol-gel processing
Malengreaux, Charline; Pirard, Sophie ULg; Léonard, Géraldine ULg et al

in Journal of Alloys and Compounds (2017), 691

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination ... [more ▼]

An aqueous sol-gel process, previously developed for producing undoped and Cu2+, Ni2+, Zn2+ or Pb2+ doped TiO2 photocatalysts with remarkably high photocatalytic activity without requiring any calcination step, has been adapted to produce Fe3+, Cr3+, La3+ or Eu3+ single-doped TiO2 photocatalysts as well as La3+-Fe3+ and Eu3+-Fe3+ co-doped TiO2 catalysts. The physicochemical properties of the obtained catalysts have been characterized using a suite of complementary techniques, including ICP-AES, XRD, UV-Vis spectroscopy, nitrogen adsorption-desorption and Fe-57 Mössbauer. The active crystalline phase is obtained without requiring any calcination step and all the different catalysts are composed of nanocrystallites of anatase with a size of 6-7 nm and a high specific surface area varying from 181 to 298 m² g-1. In this study, the effect of the NO3:Ti(IV) mole ratio used to induce the peptisation reaction during the synthesis has been studied and the results revealed that this ratio can influence significantly the textural properties of the resulting catalyst. A screening of the photocatalytic activity of the undoped and Fe3+, Cr3+, La3+ or Eu3+ single-doped and co-doped photocatalysts has been performed by evaluating the degradation of 4-nitrophenol under UV-Visible light (330 nm < λ < 800 nm). This study suggests that the photocatalytic activity is significantly influenced by the dopant nature and content with an optimal dopant content being observed in the case of Fe3+ or La3+ single-doped as well as in the case of La3+-Fe3+ and Eu3+-Fe3+ co-doped catalysts. In the case of Cr3+ single-doped catalysts, a detrimental effect of the dopant on the photocatalytic degradation of 4-nitrophenol has been observed while no significant influence of the dopant has been detected in the case of Eu3+ single-doped catalysts. The role of the different dopants in modulating the photocatalytic activity is discussed. [less ▲]

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See detailContinuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination.
Thiry, Justine ULg; Lebrun, Pierre; Vinassa, Chloé et al

in International Journal of Pharmaceutics (2016), 515(1-2), 114-124

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See detailInterpellation du genre et sujets mélancoliques. Butler lectrice d’Althusser
Borotto, Jessica ULg

in Cahiers du GRM (2016), 8

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous ... [more ▼]

Cet article propose d’explorer la manière dont Judith Butler remobilise la thèse althussérienne de l’interpellation dans La Vie psychique du pouvoir . Nous essaierons de saisir les éléments qui nous paraissent enrichir la problématique althussérienne, suggérant que la compréhension de la dimension psychique du pouvoir qui ressort de sa lecture permet de complexifier la relation du sujet au pouvoir. Afin de tisser des liens précis entre l’interpellation chez Althusser et la subjectivation chez Butler, nous examinerons d’abord le rôle que Nietzsche et Foucault recouvrent dans la formulation de la théorie de la subjectivation chez Butler. Ensuite, il s’agit de comprendre en quoi la matérialité et l’ambiguïté des mécanismes de subjectivation, qui déjà caractérisent l’interpellation althussérienne, deviennent chez Butler les sources d’une relation critique aux conditions d’émergence du sujet. Enfin nous préciserons comment elle mobilise de telles sources pour élaborer cette figure de la psychanalyse qu’est la mélancolie et pour décrire sa transformation en deuil. [less ▲]

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See detailComprehension of an organosolv process for lignin extraction on Festuca arundinacea and monitoring of the cellulose degradation
Schmetz, Quentin ULg; Maniet, Guillaume ULg; Jacquet, Nicolas ULg et al

in Industrial Crops and Products (2016), 94

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving ... [more ▼]

It is commonly accepted that the current society needs to partially substitute fossil resources by renewable ones. Among many solutions, one approach consists in the development of biorefinery involving lignocellulosic biomass to produce bio-based materials and fuels. This study focuses on the comprehension of an organosolv treatment designed to break the complex lignocellulosic structure for high purity lignin extraction from tall fescue (Festuca arundinacea Schreb.). This grass benefits from an increasing interest in Western Europe and has been suggested as feedstock for biorefinery. However, its use as material for high purity lignin production has not been determined yet. Ethanol/water, 92/8% [v/v] with H2SO4 0.32 M was investigated at pilot scale under conventional heating (5 °C min−1 during 30 min and stabilized at 148 °C for 5 min). Precipitated lignin were analyzed as well as the composition of side-stream products (recovered cellulosic pulp and the aqueous hydrolysate). Lignin has been recovered at a purity level of 90% with a yield of 60%. The main contaminants were nitrogen containing compounds and degraded hemicelluloses. 2D-HSQC NMR (Two Dimension-Heteronuclear Single Quantum Correlation Nuclear Magnetic Resonance) revealed a co-extraction of ferulates and coumarates function as well as arabinoxylan. Cellulose was recovered at 53% purity with 60% yield. The conditions appear to be too harsh for tall fescue and led to significant amount of cellulose degradation. A process using a lower alcohol concentration will be developed to provide better yields of both cellulose and lignin. [less ▲]

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See detailLearning from Incidents and Incident Reporting: Safety Governance at a Belgian Nuclear Research Center
Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Science, Technology & Human Values (2016), Online First

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews ... [more ▼]

This article examines how incidents are governed in a Belgian Nuclear Research Center by way of an incident reporting system named REX. Drawing on a documentary analysis of incident reports, interviews and focus groups with personnel, it illustrates how REX enacts a safety governmentality centered on identifying incident causes and culprits. As this governmentality mode obscures the epistemic and political character of incidents, it closes down important opportunities for collective learning about safety and safety governance. It is argued that joint reflection about incidents and resistances towards incident reporting serve as fruitful starting points for a more reflexive safety governance that makes explicit how decisions are made in high-risk contexts. Social scientists can enhance governance of this kind by pointing to different perceptions and evaluations of incidents and by insisting that contending interpretations are confronted and accounted for. [less ▲]

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See detailEditorial
Borotto, Jessica ULg; Petteni, Oriane ULg; Wustefeld, Sophie ULg et al

in Cahiers du GRM (2016), 10

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See detailSU(3) flavor symmetry breaking in large $N_c$ excited baryons
Stancu, Floarea ULg

in Physical Review. D : Particles and Fields (2016), 94

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to ... [more ▼]

The $1/N_c$ expansion method for studying the mass spectrum of excited baryons is shortly reviewed together with applications to mixed symmetric states. The $[{\bf 70, \ell^+}]$ multiplet, belonging to the $N$ = 2 band, is reanalyzed, with emphasis on hyperons and the SU(3) symmetry breaking operators entering the mass formula to first order. An important result is that the hierarchy of masses as a function of strangeness is correctly reproduced for all multiplets. Predictions for unknown excited hyperons to SU(6) $\times$ O(3) multiplets are made. [less ▲]

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See detailEffect of the Extraction Technique, Heating Time and Cryogenic Grinding (N2 at -196°C) on the Composition of Cumin Seeds Volatile Oil
Mékaoui, R; Benkaci-Ali, Farid; Scholl, Georges ULg et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2016), 19(8), 1903-1919

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and ... [more ▼]

Two techniques of extraction of essential oils (Steam distillation assisted by microwave (SDAM) and hydrodistillation assisted by microwave (HDAM)) are respectively advanced steam distillation (SD) and hydrodistillation techniques (HD), in which a microwave oven is used in the extraction process. They are considered as accelerated techniques extraction performed at atmospheric pressure. The cryogrinding (CG) showed a difference on the yields and aromatic profile comparing to the sample grinding. Isolation and concentration of volatile compounds are performed by a single stage for the extraction of volatile oil from Algerian (Sahara) Cuminum cyminum seeds (CCS). The chemical composition of the essential oil of this plant as a function of extraction time was also studied. The major components and family classes showed a significant variation with the extraction time. Gas chromatography (GC), GCxGC-mass spectrometry (GCxGC-MS)] were utilised for qualitative and quantitative analysis of essential oils extracted by these two methods. The major compounds are cumin aldehyde (HDAM-CG: 20.50-53.35 %, SDAM-CG: 21.68 66.6 %), p-cymene (HDAM-CG: 14.1-37.54 %, SDAM-CG: 6.06-20.18 %), β-pinene (HDAM-CG: 4.53-14.74 %, SDAM-CG: 4.3-32.65 %) and γ-terpinene (HDAM-CG: 1.26-14.70 %, SDAM-CG: 5.13-18.23 %). [less ▲]

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See detailLa SNCB : prête pour la libéralisation totale du rail ?
Gautier, Axel ULg; Salem, Iman

in Regards Economiques (2016)

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les ... [more ▼]

La SNCB n’a pas su s’adapter à la libéralisation du fret ferroviaire faute de rentabilité. Dans la perspective d’une libéralisation du transport de passagers annoncée pour 2023, nous évaluons les performances de l’entreprise. Notre étude met en avant un déficit de productivité et une contribution faible des passagers aux coûts par rapport à d’autres opérateurs européens. [less ▲]

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See detailNew data on the incertae sedis biota and foraminifera of the mid-Famennian Baelen Member (Late Devonian, eastern Belgium)
Vachard, Daniel; Dreesen, Roland; Mottequin, Bernard et al

in Paleobiodiversity and Paleoenvironments (2016), 21

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this ... [more ▼]

The Baelen mud mounds in eastern Belgium represent a local member of the mid-Famennian Souverain-Pré Formation (an important carbonate interval within the Condroz Sandstone Group). The lower part of this member contains silty bioclastic wackestones and packstones that are particularly rich in the problematical algae Serrisinella and Dreesenullella. Plurilocular foraminifera (Septabrunsiina and Baelenia) and rare solitary rugose corals (Neaxon? sp.) occur within crinoidal grainstones (tempestites) interfingering with the latter bioclastic wacke-/packstones and red-stained stromatactoid spiculitic mudstones (carbonate mound core facies). Although Serrisinella is quite common in other mid- and late Famennian limestones, of Belgium, Dreesenulella is almost endemic of the Baelen Member. Both genera apparently inhabited the muddy sediment-water interface, constituting meadows probably in zones of intermittently strong bottom currents. The taxonomic similarities between Dreesenulella and Saccamminopsis are discussed, as well as their possible affinities with the Xenophophyrea and Kokomiacea. Moreover, the first stages of the Septabrunsiina–Baelenia foraminiferal lineage are analysed in detail. The taxonomic and palaoecological positioning of Serrissinella and Dreesenulella adds to the discussion about the palaeobathymetry of the Baelen mud mounds and corroborates sedimentological evidence for their relatively shallow carbonate ramp depositional setting. [less ▲]

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See detailInsights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis
CHARLIER, Edith ULg; RELIC, Biserka ULg; Deroyer, Céline ULg et al

in International Journal of Molecular Sciences (2016)

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of ... [more ▼]

Abstract: Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation. Medical care is mainly based on alleviating pain symptoms. Compelling studies report the presence of empty lacunae and hypocellularity in cartilage with aging and OA progression, suggesting that chondrocyte cell death occurs and participates to OA development. However, the relative contribution of apoptosis per se in OA pathogenesis appears complex to evaluate. Indeed, depending on technical approaches, OA stages, cartilage layers, animal models, as well as in vivo or in vitro experiments, the percentage of apoptosis and cell death types can vary. Apoptosis, chondroptosis, necrosis, and autophagic cell death are described in this review. The question of cell death causality in OA progression is also addressed, as well as the molecular pathways leading to cell death in response to the following inducers: Fas, Interleukin-1 (IL-1 ), Tumor Necrosis factor- (TNF- ), leptin, nitric oxide (NO) donors, and mechanical stresses. Furthermore, the protective role of autophagy in chondrocytes is highlighted, as well as its decline during OA progression, enhancing chondrocyte cell death; the transition being mainly controlled by HIF-1 /HIF-2 imbalance. Finally, we have considered whether interfering in chondrocyte apoptosis or promoting autophagy could constitute therapeutic strategies to impede OA progression. [less ▲]

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See detailHigh resolution (1 km) positive degree-day modelling of Greenland ice sheet surface mass balance, 1870–2012 using reanalysis data
Wilton, D.; Jowett, A.; Hanna, E. et al

in Journal of Glaciology (2016), online

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature ... [more ▼]

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature parameterization as compared with a previous version and is run at 1 km rather than 5 km resolution. The improvements lead overall to higher SMB with the same forcing data. We also compare our model with results from two regional climate models (RCMs). While there is good qualitative agreement between our PDD model and the RCMs, it usually results in lower precipitation and lower runoff but approximately equivalent SMB: mean 1979–2012 SMB (± standard deviation), in Gt a−1, is 382 ± 78 in the PDD model, compared with 379 ± 101 and 425 ± 90 for the RCMs. Comparison with in situ SMB observations suggests that the RCMs may be more accurate than PDD at local level, in some areas, although the latter generally compares well. Dividing the GrIS into seven drainage basins we show that SMB has decreased sharply in all regions since 2000. Finally we show correlation between runoff close to two calving glaciers and either calving front retreat or calving flux, this being most noticeable from the mid-1990s. [less ▲]

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See detailThe role of AIP mutations in pituitary adenomas: 10 years on
Daly, Adrian ULg; BECKERS, Albert ULg

in Endocrine (2016)

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See detailAging of monolithic zirconia dental prostheses: Protocol for a 5-year prospective clinical study using ex vivo analyses
KOENIG, Vinciane ULg; Wulfman, Claudine; DERBANNE, Mathieu et al

in Contemporary Clinical Trials Communication (2016), 4

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a ... [more ▼]

Background: Recent introduction of computer-aided design/computer-aided manufacturing (CAD/CAM) monolithic zirconia dental prostheses raises the issue of material low thermal degradation (LTD), a wellknown problem with zirconia hip prostheses. This phenomenon could be accentuated by masticatory mechanical stress. Until now zirconia LTD process has only been studied in vitro. This work introduces an original protocol to evaluate LTD process of monolithic zirconia prostheses in the oral environment and to study their general clinical behavior, notably in terms of wear. Methods/design: 101 posterior monolithic zirconia tooth elements (molars and premolars) are included in a 5-year prospective clinical trial. On each element, several areas between 1 and 2 mm2 (6 on molars, 4 on premolars) are determined on restoration surface: areas submitted or non-submitted to mastication mechanical stress, glazed or non-glazed. Before prosthesis placement, ex vivo analyses regarding LTD and wear are performed using Raman spectroscopy, SEM imagery and 3D laser profilometry. After placement, restorations are clinically evaluated following criteria of the World Dental Federation (FDI), complemented by the analysis of fracture clinical risk factors. Two independent examiners perform the evaluations. Clinical evaluation and ex vivo analyses are carried out after 6 months and then each year for up to 5 years. Discussion: For clinicians and patients, the results of this trial will justify the use of monolithic zirconia restorations in dental practice. For researchers, the originality of a clinical study including ex vivo analyses of material aging will provide important data regarding zirconia properties. [less ▲]

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See detailThe influence of spatially structured soil properties on tree community assemblages at a landscape scale in the tropical forests of southern Cameroon
Vleminckx, Jason; Doucet, Jean-Louis ULg; Morin, Julie ULg et al

in Journal of Ecology (2016)

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and ... [more ▼]

Species distribution within plant communities results from both the influence of deterministic processes, related to environmental conditions, and neutral processes related to dispersal limitation and stochastic events, the relative importance of each factor depending on the observation scale. Assessing the relative contribution of environment necessitates controlling for spatial dependences among data points. Recent methods, combining multiple regression and Moran's eigenvectors maps (MEM), have been proved successful in disentangling the influence of pure spatial processes related to dispersal limitation, pure environmental variables (not spatially structured) and spatially structured environmental properties. However, the latter influence is usually not testable when using advanced spatial models like MEM. To overcome this issue, we propose an original approach, based on torus-translations and Moran spectral randomizations, to test the fraction of species abundance variation that is jointly explained by space and seven soil variables, using three environmental and tree species abundance data sets (consisting of 120, 52 and 34 plots of 0·2 ha each, located along 101-, 66- and 35-km-long transect-like inventories, respectively) collected in tropical moist forests in southern Cameroon. The overall abundance of species represented by ≥30 individuals, and 27% of these species taken individually, were significantly explained by fine-scale (<5 km) and/or broad-scale (5–100 km) spatially structured variations in soil nutrient concentrations (essentially the concentration of available Mn, Mg and Ca) along the 120-plots area. The number of significant tests considerably decreased when investigating the two smaller data sets, which mostly resulted from low statistical power rather than weaker floristic and/or edaphic variation captured among plots. Synthesis. Our results provide evidence that tree species turnovers are partly controlled by spatially structured concentrations in soil nutrients at scales ranging from few hundreds of metres to c. 100 km, a poorly documented subject in Central African forests. We also highlight the usefulness of our testing procedure to correctly interpret the space-soil fraction of variation partitioning analyses (which always accounted here for the most important part of the soil contribution), as this fraction was sometimes relatively high (R2 values up to c. 0·3) but nearly or not significant. [less ▲]

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See detailLimited Impact of Imatinib in a Murine Model of Sclerodermatouc Chronic Graft-versus-Host Disease
Belle, Ludovic; Fransolet, Gilles ULg; Somja, Joan ULg et al

in PLoS ONE (2016)

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β ... [more ▼]

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impact of the PDGF-r and c-Abl tyrosine kinase inhibitor imatinib on scl-cGVHD. Methods To assess the impact of imatinib on T cell subset proliferation in vivo, Balb/cJ recipient mice were lethally (7 Gy) irradiated and then injected with 10x106 bone marrow cells from B10.D2 mice on day 0. Fourteen days later, 70x106 carboxyfluorescein succinimidyl ester (CFSE)- labeled splenocytes from B10.D2 mice were infused and imatinib or sterile water was administered for 5 days. To induce severe scl-cGVHD, Balb/cJ mice were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donor mice after 7 Gy irradiation. Mice were then given sterile water or imatinib from day +7 after transplantation to the end of the experiment (day +52). Results Imatinib decreased the proliferation of total T cells (P = 0.02), CD8+ T cells (P = 0.01), and of regulatory T cells (Tregs) (P = 0.02) in the spleen. In the severe scl-cGVHD model, imatinib- treated mice had significantly lower levels of PDGF-r phosphorylation than control mice on day 29 after transplantation (P = 0.008). However, scl-cGVHD scores were similar between vehicle- and imatinib-treated mice during the whole experiment, while there was a suggestion for less weight loss in imatinib-treated mice that reached statistical significance at day +52 following transplantation (P = 0.02). [less ▲]

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See detailCorrecting circulation biases in a lower-resolution global general circulation model with data assimilation
Canter, Martin ULg; Barth, Alexander ULg; Beckers, Jean-Marie ULg

in Ocean Dynamics (2016)

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional ... [more ▼]

In this study, we aim at developing a new method of bias correction using data assimilation. This method is based on the stochastic forcing of a model to correct bias by directly adding an additional source term into the model equations. This method is presented and tested first with a twin experiment on a fully controlled Lorenz ’96 model. It is then applied to the lower-resolution global circulation NEMO-LIM2 model, with both a twin experiment and a real case experiment. Sea surface height observations are used to create a forcing to correct the poorly located and estimated currents. Validation is then performed throughout the use of other variables such as sea surface temperature and salinity. Results show that the method is able to consistently correct part of the model bias. The bias correction term is presented and is consistent with the limitations of the global circulation model causing bias on the oceanic currents. [less ▲]

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See detailBrisons le système, pouvoir aux femmes ! (Padoue, 1974)
Borotto, Jessica ULg

in Cahiers du GRM (2016), 10

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See detailIntroduction du Dossier de traduction
Borotto, Jessica ULg; Cavazzini, Andrea

in Cahiers du GRM (2016), 10

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See detailIn vitro evaluation of biocompatibility of uncoated thermally reduced graphene and carbon nanotube-loaded PVDF membranes with adult neural stem cell-derived neurons and glia
Defteralı, Çağla; Verdejo, Raquel; Majeed, Shahid et al

in Frontiers in Bioengineering and Biotechnology (2016), 4(n° 64),

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were ... [more ▼]

Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were seeded on these materials coated with various proteins implying that the observed effects on the cells could not solely be attributed to the GBN and CNT properties. Here, we studied the biocompatibility of uncoated thermally reduced graphene (TRG) and poly(vinylidene fluoride) (PVDF) membranes loaded with multi-walled CNTs (MWCNTs) using neural stem cells isolated from the adult mouse olfactory bulb (termed aOBSCs). When aOBSCs were induced to differentiate on coverslips treated with TRG or control materials (polyethyleneimine-PEI and polyornithine plus fibronectin- PLO/F) in a serum-free medium, neurons, astrocytes, and oligodendrocytes were generated in all conditions, indicating that TRG permits the multi-lineage differentiation of aOBSCs. However, the total number of cells was reduced on both PEI and TRG. In a serum-containing medium, aOBSC-derived neurons and oligodendrocytes grown on TRG were more numerous than in controls; the neurons developed synaptic boutons and oligodendrocytes were more branched. In contrast, neurons growing on PVDF membranes had reduced neurite branching, and on MWCNTs-loaded membranes oligodendrocytes were lower in numbers than in controls. Overall, these findings indicate that uncoated TRG may be biocompatible with the generation, differentiation, and maturation of aOBSC-derived neurons and glial cells, implying a potential use for TRG to study functional neuronal networks. [less ▲]

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See detailRésister à l’essentialisation de l’Allemagne : Les Temps Modernes, revue franco-allemande ?
Franck, Thomas ULg

in Trajectoires (2016), 10

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen ... [more ▼]

Im Zentrum des vorliegenden Aufsatzes steht die Doppelausgabe (46-47) der französischen Zeitschrift Temps Modernes, die unter dem Titel „Allemagne“ im August-September 1949 erschien und einen besonderen Fall von kulturellem und intellektuellem Transfer zwischen Deutschland und Frankreich darstellt. Mit Mitteln der Diskursanalyse und der Imagologie sollen hier rhetorische Strategien herausgearbeitet werden, die der Realisierung eines kritischen Projekts und der Anprangerung der Stereotypen dienen, die Deutschland damals zugeschrieben wurden. Aufgestellt wird folgende These: Indem sie Intellektuelle aus unterschiedlichen Orten und Disziplinen und heterogenes Wissen zusammenbringt, bietet sich die Zeitschrift besonders gut für eine kritische Reflexion der herrschenden Ideologien und kollektiven Überzeugungen an. Indem es Deutschen mit kommunistischer und antifaschistischer Gesinnung das Wort erteilt, will das Heft „Allemagne“ zu Erkenntnissen über ein ‚anderes Deutschland‘ kommen, das von Aufstand und Widerstand geprägt ist, und bricht so mit einer Reduktion des Landes auf eine unveränderliche und monolithische Identität, die als gleichermaßen fügsam und autoritär verstanden wurde. [less ▲]

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See detailDynamics of the flares in the active polar region of Jupiter
Bonfond, Bertrand ULg; Grodent, Denis ULg; Badman, S. V. et al

in Geophysical Research Letters (2016)

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV ... [more ▼]

The dusk-side of the polar region of Jupiter's UV aurorae, called the active region, sometimes exhibits quasi-periodic (QP) flares on time-scales of 2-3 minutes. Based on Hubble Space Telescope Far-UV time-tag images, we show for the first time that the northern hemisphere also displays QP-flares. The area covered by these flares can reach up to 2.4 × 108 km2 (i.e. the whole active region), but often only involves an area an order of magnitude smaller. Using a magnetic field mapping model, we deduced that these areas correspond to the dayside outer magnetosphere. In our dataset, quasi-periodic features are only seen on half of the cases and even on a given observation, a region can be quiet for one half and blinking on the other half. Consecutive observations in the two hemispheres show that the brightening can occur in phase. Combined with the size and location of the flares, this behaviour suggests that the QP-flares most likely take place on closed magnetic field lines. [less ▲]

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See detailAging Processes in Lithiated FeSn2 Based Negative Electrode for Li-ion Batteries: a New Challenge for Tin Based Intermetallic Materials
chamas, mohamad; Mahmoud, Abdelfattah ULg; Tang, Junlei et al

in Journal of Physical Chemistry C (2016)

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in ... [more ▼]

Tin based intermetallic compounds proposed as negative electrode materials for Li-ion batteries not only suffer from capacity fade during cycling due to volume variations but also from aging phenomena in lithiated states. By using FeSn2 as a model compound, we propose an analysis of this process by combining electrochemical potential measurements, 119Sn and 57Fe Mössbauer spectroscopies, magnetic measurements and impedance spectroscopy. We show that the Fe/Li7Sn2 composite obtained at the end of the first discharge is progressively transformed during the aging process occurring within the electrochemical cell in open circuit condition. The Fe nanoparticles are stable while the Li7Sn2 nanoparticles are progressively delithiated with time leading to Sn-rich LixSn nano-alloys without observable back reaction with Fe. The deinserted lithium atoms react with the electrolyte and modify the surface electrode interphase (SEI) by increasing its thickness and/or decreasing its porosity [less ▲]

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See detailLa reconnaissance des génocides et la répression du négationnisme
Grandjean, Geoffrey ULg

in Courrier Hebdomadaire du CRISP (2016), 2304-2305

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour ... [more ▼]

La reconnaissance politique d’un génocide et la répression de la négation de celui-ci représentent deux enjeux d’une grande importance symbolique. Surtout, elles constituent un exercice très délicat pour l’autorité politique qui pose de tels actes. Il s’agit en effet de consacrer une vérité historique et de dicter le souvenir qui doit en être véhiculé. L’intervention d’une instance politique dans le champ de l’histoire et de la mémoire est toujours entourée de nombreux débats. Les discussions, souvent vives, portent sur diverses questions. Le principe d’une action législative dans un tel domaine est-il recevable et pertinent ? Quelle définition de « génocide » convient-il d’adopter ? La répression du négationnisme est-elle de nature à justifier une limitation de la liberté d’expression ? Si oui, dans quelle mesure cette restriction s’applique-t-elle aussi aux chercheurs ? Lorsqu’il s’agit d’événements historiques relatifs à un autre État, faut-il faire primer l’éthique et la morale sur la diplomatie ? Les réponses à ces interrogations fondamentales se cristallisent dans des lignes de fracture qui échappent aux clivages partisans classiques. En Belgique, les initiatives de reconnaissance des crimes de génocide et de pénalisation de leur négation sont le fait des deux chambres du Parlement fédéral. Elles ont abouti à diverses dispositions législatives, telles la loi réprimant la négation du génocide commis par le régime nazi à l’encontre des Juifs pendant la Seconde Guerre mondiale (1995), une résolution relative au génocide perpétré par l’Empire ottoman à l’encontre des Arméniens en 1915 (1998), une résolution sur le génocide des Tutsis au Rwanda en 1994 (2004) et une résolution relative à la commémoration du centenaire du génocide arménien (2015). G. Grandjean retrace et éclaire l’ensemble des débats parlementaires qui se sont tenus en Belgique depuis 1992 autour de la question de la mémoire des crimes de masse. Son Courrier hebdomadaire offre les clés de lecture pour la compréhension des débats en cours quant à une extension de la loi de 1995. [less ▲]

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See detailLarge neighborhood search for multi-trip vehicle routing
François, Véronique ULg; Arda, Yasemin ULg; Crama, Yves ULg et al

in European Journal of Operational Research (2016), 255(2), 422-441

We consider the multi-trip vehicle routing problem, in which each vehicle can perform several routes during the same working shift to serve a set of customers. The problem arises when customers are close ... [more ▼]

We consider the multi-trip vehicle routing problem, in which each vehicle can perform several routes during the same working shift to serve a set of customers. The problem arises when customers are close to each other or when their demands are large. A common approach consists of solving this problem by combining vehicle routing heuristics with bin packing routines in order to assign routes to vehicles. We compare this approach with a heuristic that makes use of specific operators designed to tackle the routing and the assignment aspects of the problem simultaneously. Two large neighborhood search heuristics are proposed to perform the comparison. We provide insights into the configuration of the proposed algorithms by analyzing the behavior of several of their components. In particular, we question the impact of the roulette wheel mechanism. We also observe that guiding the search with an objective function designed for the multi-trip case is crucial even when exploring the solution space of the vehicle routing problem. We provide several best known solutions for benchmark instances. [less ▲]

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See detailWASP-157b, a Transiting Hot Jupiter Observed with K2
Močnik, T.; Anderson, D. R.; Brown, D. J. A. et al

in Publications of the Astronomical Society of the Pacific (2016), 970

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 ... [more ▼]

We announce the discovery of the transiting hot Jupiter WASP-157b in a 3.95-d orbit around a V = 12.9 G2 main-sequence star. This moderately inflated planet has a Saturn-like density with a mass of $0.57 \pm 0.10$ M$_{\rm Jup}$ and a radius of $1.06 \pm 0.05$ R$_{\rm Jup}$. We do not detect any rotational or phase-curve modulations, nor the secondary eclipse, with conservative semi-amplitude upper limits of 250 and 20 ppm, respectively. [less ▲]

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See detailKilling it Softly: Girdling as an Efficient Eco-friendly Method to Locally Remove the Invasive Acer negundo
Merceron, Nastasia ULg

in Ecological Restoration (2016), 34(4), 297-305

Acer negundo (boxelder maple) is a North American native tree species that currently invades riparian and disturbed areas in Europe, affecting both bank stability and ecosystem biodiversity. As a response ... [more ▼]

Acer negundo (boxelder maple) is a North American native tree species that currently invades riparian and disturbed areas in Europe, affecting both bank stability and ecosystem biodiversity. As a response to managers’ requests, we aimed at finding an eco-friendly method which would locally remove this species and help habitat restoration. Four control methods were tested on A. negundo adults and saplings from stands located in three experimental sites along different watercourses in Southwestern France: girdling, low cutting, high cutting, and cutting followed by the application of juglone (a natural allelopathic substance from walnut tree leaves). Mortality and resprout production on the treated A. negundo individuals were assessed during two years following the application of the control methods. Girdling was the most efficient method as it significantly induced higher mortality rates compared to the others (65 vs 15% of dead A. negundo two years after treatment administration). When healing emerged on trunks, yearly repeated girdling was required to reach full success. None of the control methods significantly reduced resprout production; not even the application of juglone. Girdling is the most recommended method to kill and remove A. negundo at a local scale in invaded natural habitats. Considering that A. negundo benefits from increases in light availability to outcompete native species, we further recommend removing seedlings from understories when applying girdling on adult and sapling individuals in order to optimize restoration conditions in natural stands and improve native species re-establishment. [less ▲]

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