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See detailMetabolic variability in bioprocessing : implications of microbial phenotypic heterogeneity
Delvigne, Frank ULg; Zune, Quentin ULg; Lara, Alvaro et al

in Trends in Biotechnology (in press)

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See detailUn type picard par-delà les frontières : le <nom jeté>
Baiwir, Esther ULg

in Dialectes de Wallonie (in press), 36

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See detailPoplar-root-knot nematode interaction: a model for perennial woody species
Baldacci-Cresp, Fabien; Sacre, Pierre-Yves ULg; Twyffels, Laure et al

in Molecular Plant-Microbe Interactions [=MPMI] (in press)

Plant root-knot nematode interaction studies are performed on several host plant models. However, even though root-knot nematodes interact with trees, no perennial woody model has been explored so far. We ... [more ▼]

Plant root-knot nematode interaction studies are performed on several host plant models. However, even though root-knot nematodes interact with trees, no perennial woody model has been explored so far. We show here that poplar (Populus tremula x Populus alba) grown in vitro is susceptible to Meloidogyne incognita as this nematode is able to penetrate, to induce feeding sites and to reproduce in poplar roots. As analyzed by Raman spectromicroscopy, the cell walls of the giant cells, with typical characteristics of transfer cell walls, were not lignified and were composed mainly of pectin and cellulose. To better depict the poplar-nematode interaction at the molecular level, a quantitative RT-PCR analysis was performed to study changes in poplar gene expression in galls compared to non-infected roots. Three marker genes, reported for other plant hosts, including expansin A, histone 3.1 and asparagine synthase, were conserved for poplar-nematode interaction. In addition, the down-regulation of four genes coding for enzymes of the lignin biosynthesis pathway was evidenced in galls, suggesting a modification in lignin composition within galls developed in poplar roots. Together, this study shows that poplar is a suitable model host for specific traits of tree-nematode interaction. [less ▲]

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See detailInsecticidal activity of Lavandula angustifolia Mill. against Acyrtosiphum pisum
Attia, Sabrine; Lognay, Georges ULg; Heuskin, Stéphanie ULg et al

in journal of entomology and zoology studies (in press)

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most ... [more ▼]

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most abundant component (38.57%), followed by linalyl acetate (29.95%), 1,8-cineole (13,66%), camphor (13,13%), -pinene (3,14%) and terpinene-4-ol (1,54%). The Mortality was measured upon treatment with oil concentrations ranging from 5 to 25 µl.l-1 of air. The mortality of aphids increased with oil concentration and LC50 values were determined to be 11.2 µl.l-1 of air. The full mixture was also prepared and toxicity was compared with individual constituents. The results showed that the presence of all constituents were necessary to equal the toxicity of the natural oils L. angustifolia oil can provide valuable pesticide activity with significantly lower LC50 values [less ▲]

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See detailULTRASONOGRAPHIC FINDINGS IN 13 HORSES WITH LYMPHOMA
Janvier, Valentin; Evrard, Laurence ULg; Cerri, Simona ULg et al

in Veterinary Radiology & Ultrasound (in press)

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See detailGlioblastoma-derived extracellular vesicles induce tumor-supportive phenotypes in monocytic cells
de Vrij, Jeroen; Maas, Sybren; Kwappenberg, Kitty et al

in International Journal of Cancer = Journal International du Cancer (in press)

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See detailRoot-emitted volatile organic compounds: can they mediate belowground plant-plant interactions?
Delory, Benjamin ULg; Delaplace, Pierre ULg; Fauconnier, Marie-Laure ULg et al

in Plant and Soil (in press)

Background Aboveground, plants release volatile organic compounds (VOCs) that act as chemical signals between neighbouring plants. It is now well documented that VOCs emitted by the roots in the plant ... [more ▼]

Background Aboveground, plants release volatile organic compounds (VOCs) that act as chemical signals between neighbouring plants. It is now well documented that VOCs emitted by the roots in the plant rhizosphere also play important ecological roles in the soil ecosystem, notably in plant defence because they are involved in interactions between plants, phytophagous pests and organisms of the third trophic level. The roles played by root-emitted VOCs in between- and within-plant signalling, however, are still poorly documented in the scientific literature. Scope Given that (1) plants release volatile cues mediating plant-plant interactions aboveground, (2) roots can detect the chemical signals originating from their neighbours, and (3) roots release VOCs involved in biotic interactions belowground, the aim of this paper is to discuss the roles of VOCs in between- and within-plant signalling belowground. We also highlight the technical challenges associated with the analysis of root-emitted VOCs and the design of experiments targeting volatile-mediated root-root interactions. Conclusions We conclude that root-root interactions mediated by volatile cues deserve more research attention and that both the analytical tools and methods developed to study the ecological roles played by VOCs in interplant signalling aboveground can be adapted to focus on the roles played by root-emitted VOCs in between- and within-plant signalling. [less ▲]

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See detailBiochemical characterization of the oil of durum wheat germ (Tunisian variety)
Kammoun, Maroua; Rassâa, Neila; Mejri-Gaïda, Myriam et al

in Journal of New Sciences (in press)

The wheat germ oil may constitute an alternative to the misuse of this cereal grain resource. The Tunisian exploitation is limited, at present, in the human and animal feed in the grain form, straw or ... [more ▼]

The wheat germ oil may constitute an alternative to the misuse of this cereal grain resource. The Tunisian exploitation is limited, at present, in the human and animal feed in the grain form, straw or some transformed products. For the purpose of characterization, the wheat germ oil has been extracted by Soxhlet apparatus from a Tunisian variety of durum wheat (Maali) based on the hexane as a solvent. An analysis by gas chromatography (GC) was then performed to identify and quantify the fatty acids of the oil. Then, the oil has submitted to a second chromatography analysis in liquid phase (HPLC) to quantify the tocopherols. The most important fatty acids constituting have been the two polyunsaturated acids linoleic acid C18:2 (OMEGA 6) and the gamma acid- linoleic C18:3 : 58.24 % and 4.19 % respectively; and the acid monounsaturated oleic acid C18:1 ( 24.49 %) but also some saturated acid: palmitic acid C16:0 with ( 19.50 % ), and the stearic acid C18:0 (1.29%). For this variety of Tunisian durum wheat, the wheat germ oil contains, in addition, 80.27 mg / 100g of α- tocopherols (vitamin E). The wheat germ oil extracted from the Tunisian variety 'Maali' has proved rich in vitamin E and omega-6 ; a better valorisation on the nutritional or pharmaceutical plan is to this title recommended. [less ▲]

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See detailNew insight on Carboniferous (Viséan) brachiopods from eastern Tafilalt (Morocco)
Mottequin, Bernard; Denayer, Julien ULg; Herbig, Hans-Georg et al

in Geological Journal (in press)

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See detailFrémok: Comics Out-of-Bounds
Dejasse, Erwin ULg

in World Literature Today (in press)

Article about that analize the history, background and publishing policity of French-Belgian publisher Frémok

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See detailLa collaboration entre architectes et plasticiens à Liège dans les années 1930.
Charlier, Sébastien ULg

in In Situ, revue des patrimoines (in press), 26

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales ... [more ▼]

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales, le mensuel revendique une vision transversale de l’architecture où la réflexion plastique occupe une place centrale. Dès le départ, elle s’associe à Anthologie, revue imprégnée des théories futuristes et qui diffuse les artistes de l’avant-garde locale. D’abord par le biais de l’édition et des expositions, plasticiens et architectes travaillent ensuite ensemble dans le cadre de projets ambitieux financés par les pouvoirs publics. Cette contribution revient aux racines de cette collaboration en définissant les liens théoriques ou personnels unissant les deux revues. En se concentrant sur les infrastructures publiques, elle comment les artistes et les architectes ont répondu ensemble aux exigences concrètes de la commande en les replaçant dans le contexte social, politique et économique d’une ville belge de seconde importance à la veille de la Seconde Guerre mondiale. [less ▲]

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See detailLoop
Levaux, Christophe ULg

in Rock Music Studies (in press)

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See detailMolecular detection of bovine noroviruses in Argentinean dairy calves: Circulation of a tentative new genotype
Ferragut, Fatima; Vega, Celina; Mauroy, Axel ULg et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (in press)

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See detailEmergent identity formation and the co-operative: Theory building in relation to alternative organizational forms
Nelson, Teresa; Nelson, Dylan; Huybrechts, Benjamin ULg et al

in Entrepreneurship and Regional Development (in press)

How are identities of alternative forms of organization constructed and how does this process differ relative to normative forms socially expected? In this research we consider identity formation in co ... [more ▼]

How are identities of alternative forms of organization constructed and how does this process differ relative to normative forms socially expected? In this research we consider identity formation in co-operatives, a population of organizations allied globally through values and practices such as democratic participation, voluntary and open membership, and limited return to capital investment. As an extension of current thinking on identity formation in entrepreneurship and organizational theory, we use co-operatives to explore social expectations and institutional arrangements around form at the societal, population, and organizational levels using a population ecology framework. We develop a research agenda based on propositions that address specific features of identity formation in less typical forms of organization, including tensions with normative business expectations, engagement with identity audiences, embeddedness in networks and alliances, structural factors influencing identity, and identity ambiguity. [less ▲]

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See detailHigh concentrations of Myeloperoxidase in the equine uterus as an indicator of endometritis
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Franck, Thierry ULg et al

in Theriogenology (in press)

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears ... [more ▼]

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears. Studies show a relation between neutrophils and myeloperoxidase (MPO), an enzyme contained in and released by neutrophils during degranulation or after cell lysis. This enzyme has been found in many fluids and tissues and associated with different inflammatory pathologies in the horse. The aims of this study were to assess the presence and concentration of MPO in the equine uterus, and to investigate its relation with neutrophils, and other clinical signs of endometritis. Mares (n=51) were evaluated for presence of intra-luminal fluid and excessive endometrial edema before breeding, and a small volume lavage and cytology samples were obtained. From 69 cycles, supernatant of the uterine flushes was analysed with a specific equine MPO ELISA assay to measure MPO concentration. Cytology samples were used for the diagnosis of endometritis. MPO was present in the uterus of all estrus mares in highly variable concentrations. MPO concentrations were significantly (p<0.05) higher in samples with positive cytologies and in presence of intra-luminal fluid. Occasionally, some samples with negative cytologies showed high MPO concentration, but the opposite was never observed. Cycles presenting hyper-edema weren’t associated to high concentration of MPO, intra-luminal fluid or positive cytology making it a poor diagnostic tool of endometritis. [less ▲]

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See detailIs the sword moss (Bryoxiphium) a preglacial Tertiary relict?
Patino, J.; Goffinet, B.; Sim-Sim, M.A. et al

in Molecular Phylogenetics & Evolution (in press)

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See detailInhibitory deterioration may contribute to hallucinations in Alzheimer’s disease
El Haj, Mohamad; Laroi, Frank ULg; Gély-Nargeot, Marie-Christine et al

in Cognitive Neuropsychiatry (in press)

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See detailPhenotypic variability in bioprocessing conditions can be tracked on the basis of on-line flow cytometry and fits to a scaling law
Baert, Jonathan ULg; Kinet, Romain ULg; Brognaux, Alison ULg et al

in Biotechnology Journal (in press)

Noise in gene and protein expression is a major cause for bioprocess deviation. However, this phenomenon has been only scarcely considered in real bioprocessing conditions. In this work, a scaling-law ... [more ▼]

Noise in gene and protein expression is a major cause for bioprocess deviation. However, this phenomenon has been only scarcely considered in real bioprocessing conditions. In this work, a scaling-law derived from a genome-scale studies based on GFP reporter systems has been calibrated to an on-line flow cytometry device, allowing thus to get an insight at the level of promoter activity and associated noise during a whole microbial culture carried out in bioreactor. We show that most of the GFP reporter systems investigated and thus corresponding genes could be included inside the area covered by the scaling-law. The experimental results suggest that this scaling-law could be used to predict the dynamics of promoter activity, as well as the associated noise, in bioprocessing conditions. The knowledge acquired throughout this work could be used for the design of more robust expression systems. [less ▲]

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See detailPhysiological and bio-functional properties of gum arabic: a notable interest for certain human diseases
Eloundou Mballa, Pierre; Goffin, Dorothée ULg; Destain, Jacqueline ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (in press)

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detailLes associations des enfants et jeunes travailleurs du Burkina Faso comme espace d’expression de la capacité d’action des enfants ?
Wouango, Joséphine ULg

in Enfances Familles Générations (in press)

Les Associations des Enfants et Jeunes Travailleurs du Burkina Faso (AEJT/BF) sont une représentation nationale du Mouvement Africain des Enfants et Jeunes Travailleurs (MAEJT), créé à la fin des années ... [more ▼]

Les Associations des Enfants et Jeunes Travailleurs du Burkina Faso (AEJT/BF) sont une représentation nationale du Mouvement Africain des Enfants et Jeunes Travailleurs (MAEJT), créé à la fin des années 1980. Le mouvement est fondé sur deux grands principes : les douze droits prioritaires des enfants et jeunes travailleurs et le principe du « protagonisme » (l’enfant travailleur comme acteur capable) . Ce chapitre présente et analyse le fonctionnement de ce mouvement au Burkina Faso, les changements qu’il a contribué à apporter à la question sociale du travail des enfants et les résultats de la mise en application des principes annoncés. S’appuyant sur une enquête ethnographique menée en son sein, le texte offre des données inédites sur les réalités d’un acteur collectif qui, en utilisant à son avantage la rhétorique de la « participation » des enfants (art.12, Convention des droits de l’enfant), a réussi à s’insérer dans l’arène nationale de la protection de l’enfance. Toutefois, la question de la place et du rôle des enfants ainsi que celle du “vieillissement” des membres sont quelques-uns des défis auxquels la section burkinabè du mouvement doit faire face. [less ▲]

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See detailLarge-Eddy Simulations of microcarrier exposure to potentially damaging eddies inside mini-bioreactors
Collignon, Marie-Laure ULg; Delafosse, Angélique; Calvo, Sébastien ULg et al

in Biochemical Engineering Journal (in press)

Mechanically stirred vessels equipped with rotating impellers generate heterogeneous transitional or turbulent flows. However, some cells as animal or human mesenchymal stem cells (hMSC) adhered on ... [more ▼]

Mechanically stirred vessels equipped with rotating impellers generate heterogeneous transitional or turbulent flows. However, some cells as animal or human mesenchymal stem cells (hMSC) adhered on microcarriers, are reputed sensitive to hydromechanical stresses arising from stirring. Many publications, especially using Computational Fluid Dynamics, characterize spatial fields of velocity and turbulence inside bioreactors but the exposure frequency to these stresses is never taken into account in the case of animal cell culture bioreactor description. To fill this gap, this study used both CFD Reynolds-Averaged and Large-Eddy Simulations to characterize the hydrodynamics inside 250 mL mini-bioreactors, which is a relevant volume for hMSC cultures. Five impeller geometries were studied. From the velocity and turbulence fields calculated, an energy dissipation/circulation function, related to both frequency and intensity of potentially damaging hydrodynamic events for the cells, was determined for various operating conditions. Based on the simulation results, the marine propeller operating in up-pumping mode seems to be the most adapted condition, since it exhibits a low frequency of exposure to an acceptable intensity of the turbulent dissipation rate. From a general point of view, the new methodology proposed should be used in the future to screen the most adapted bioreactor geometry to biological constraints. [less ▲]

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See detailGeographic range in liverworts: does sex really matter?
Laenen, B.; Machac, A.; Gradstein, S.R. et al

in Journal of Biogeography (in press)

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See detailPower System Dynamic Simulations using a Parallel Two-level Schur-complement Decomposition
Aristidou, Petros; Lebeau, Simon; Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (in press)

As the need for faster power system dynamic simulations increases, it is essential to develop new algorithms that exploit parallel computing to accelerate those simulations. This paper proposes a parallel ... [more ▼]

As the need for faster power system dynamic simulations increases, it is essential to develop new algorithms that exploit parallel computing to accelerate those simulations. This paper proposes a parallel algorithm based on a two-level, Schur complement-based, domain decomposition method. The two-level partitioning provides high parallelization potential (coarse and fine-grained). In addition, due to the Schur-complement approach used to update the sub-domain interface variables, the algorithm exhibits high global convergence rate. Finally, it provides significant numerical and computational acceleration. The algorithm is implemented using the shared-memory parallel programming model, targeting inexpensive multi-core machines. Its performance is reported on a real system as well as on a large test system combining transmission and distribution networks. [less ▲]

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See detailEstimating the out-of-sample predictive ability of trading rules: a robust bootstrap approach
Hambuckers, julien ULg; Heuchenne, Cédric ULg

in Journal of Forecasting (in press)

In this paper, we provide a novel way to estimate the out-of-sample predictive ability of a trading rule. Usually, this ability is estimated using a sample splitting scheme, true out-of-sample data being ... [more ▼]

In this paper, we provide a novel way to estimate the out-of-sample predictive ability of a trading rule. Usually, this ability is estimated using a sample splitting scheme, true out-of-sample data being rarely available. We argue that this method makes a poor use of the available data and creates data mining possibilities. Instead, we introduce an alternative .632 bootstrap approach. This method enables to build in- sample and out-of-sample bootstrap datasets that do not overlap but exhibit the same time dependencies. We show in a simulation study that this technique drastically reduces the mean squared error of the estimated predictive ability. We illustrate our methodology on IBM, MSFT and DJIA stock prices, where we compare 11 trading rules speci cations. For the considered datasets, two different filter rule specifications have the highest out-of-sample mean excess returns. However, all tested rules cannot beat a simple buy-and-hold strategy when trading at a daily frequency. [less ▲]

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See detailSurvivances et métamorphoses. Les gemmes isiaques remployées au Moyen Âge et leur interprétation
Veymiers, Richard ULg

in Anabases : Traditions et Réception de l'Antiquité (in press)

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailSU(3) Clebsch-Gordan coefficients at large $N_c$
Stancu, Floarea ULg

in Nuclear Physics A (2016), 945

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic ... [more ▼]

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic formulae derived by Hecht in 1965 in the context of nuclear physics. This is valid for irreducible representations with multiplicity one in the corresponding Clebsch-Gordan series. For multiplicity two, Hecht has proposed an alternative which can provide correct $1/N_c$ sub-leading orders in large $N_c$ studies. [less ▲]

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See detailStatistically Bundled Shewhart Control Charts for Monitoring Delivery Chains Systems
Foster, Earnest; Faraz, Alireza ULg; Heuchenne, Cédric ULg

in European Journal of Industrial Engineering (2016)

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the ... [more ▼]

Continuous monitoring of Delivery Time variables by means of control charts in a delivery chain is a very recent application of Statistical Process Control (SPC) to the service sector. The aim of the proposed method is to provide supply chain decision makers with an easy to be managed tool monitoring the current functioning state of the delivery chain. The implementation of SPC control charts makes it possible to limit over-corrections to false alarm conditions and to maintain at an acceptable level the safety stock, with a consequent reduction of the overall management costs of the delivery chain. An illustrative example shows the proposed control chart implementation in a real delivery chain. [less ▲]

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See detailPerformance et Innovation en PME: une relation à questionner
Ajzen, Michel; Rondeaux, Giseline ULg; Pichault, François ULg et al

in Revue Internationale P.M.E. (2016), 29(2),

Noting that in management science, management policies would have all, the ultimate ambition of contributing to company performance and the innovative capacity of a company would be a sine qua non of this ... [more ▼]

Noting that in management science, management policies would have all, the ultimate ambition of contributing to company performance and the innovative capacity of a company would be a sine qua non of this performance, this article shows that (if) these two concepts refer to disparate content; (ii) the performance is primarily measured by distanced indicators (financial); (iii) the nature of the interdependence between innovation and performance is not unequivocal. Considering the weight of contextual variables, we show the interest to adopt a broader vision of concepts of innovation and performance in SMEs, capitalizing on the diversity of performance and innovation characterizations, and adopting an agnostic approach establishing no a priori link between them. This article proposes to broaden the concepts of innovation and performance by mobilizing indicators specific to SMEs and outlines a methodology to measure and weigh them as well as to provide researchers with tools to better understand the interactions between these variables. In doing so, we contribute to a critical approach of de-naturalization to emancipate SMEs and, more broadly, public and regulatory authorities, from narrow performative standards. [less ▲]

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See detailA simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a Hot-Melt Extrusion process
Netchacovitch, Lauranne ULg; Thiry, Justine ULg; De Bleye, Charlotte ULg et al

in Talanta (2016), 154

When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must ... [more ▼]

When developing a new formulation, the development, calibration and validation steps of analytical methods based on vibrational spectroscopy are time-consuming. For each new formulation, real samples must be produced and a “reference method” must be used in order to determine the Active Pharmaceutical Ingredient (API) content of each sample. To circumvent this issue, the paper presents a simple approach based on the film-casting technique used as a calibration tool in the framework of hot-melt extrusion process. Confocal Raman microscopic method was successfully validated for the determination of itraconazole content in film-casting samples. Then, hot-melt extrusion was carried out to produce real samples in order to confront the results obtained with confocal Raman microscopy and Ultra High Performance Liquid Chromatography (UHPLC). The agreement between both methods was demonstrated using a comparison study based on the Bland and Altman’s plot. [less ▲]

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See detailMulti-species measurements of nitrogen isotopic composition r 1 eveal the spatial constraints and 2 biological drivers of ammonium attenuation across a highly contaminated groundwater system
Wells, Naomi S.; Hakoun, Vivien ULg; Brouyère, Serge ULg et al

in Water Research (2016), 98

Groundwater under industrial sites is characterised by heterogeneous chemical mixtures, making it difficult to assess the fate and transport of individual contaminants. Quantifying the in-situ biological ... [more ▼]

Groundwater under industrial sites is characterised by heterogeneous chemical mixtures, making it difficult to assess the fate and transport of individual contaminants. Quantifying the in-situ biological removal (attenuation) of nitrogen (N) is particularly difficult due to its reactivity and ubiquity. Here a multi-isotope approach is developed to distinguish N sources and sinks within groundwater affected by complex industrial pollution. Samples were collected from 70 wells across the two aquifers underlying a historic industrial area in Belgium. Below the industrial site the groundwater contained up to 1000 mg Nl-1 ammonium (NH4 +) and 300 mg N l-1 nitrate (NO3-), while downgradient concentrations decreased to ~1 mg l-1 DIN ([DIN] = [NH4+-N] + [NO3--N] + [NO2--N]). Mean δ1534 N-DIN increased from ~2‰ to +20‰ over this flow path, broadly confirming that biological N attenuation drove the measured concentration decrease. Multi-variate analysis of water chemistry identified two distinct NH4+ sources (δ15N-NH4+ from -14‰ and +5‰) within the contaminated zone of both aquifers. Nitrate dual isotopes co-varied (δ15 N: -3‰ - +60‰; δ18O: 0‰ - +50‰) within the range expected for coupled nitrification and denitrification of the identified sources. The fact that δ15N-NO2- values were 50‰ to 20‰ less than δ15N-NH4+ values in 40 the majority of wells confirmed that nitrification controlled N turnover across the site. However, the fact that δ15N-NO2- was greater than δ15N-NH4+ in wells with the highest [NH4+] shows that an autotrophic NO2- reduction pathway (anaerobic NH4+ oxidation or nitrifier-denitrification) drove N attenuation closest to the contaminant plume. This direct empirical evidence that both autotrophic and heterotrophic biogeochemical processes drive N attenuation in contaminated aquifers demonstrates the power of multiple N isotopes to untangle N cycling in highly complex systems. [less ▲]

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See detailScreening study of SFC critical method parameters for the determination of pharmaceutical compounds
Dispas, Amandine ULg; Lebrun, Pierre ULg; Sacre, Pierre-Yves ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2016), 125

Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and ... [more ▼]

Nowadays, supercritical fluid chromatography is commonly presented as a promising alternative technique in the field of separation sciences. Nevertheless the selection of chromatographic conditions and sample preparation of pharmaceutical compounds remain a challenge and peak distortion was previously highlighted. The main objective of the present work was to evaluate the impact of different critical method parameters (CMPs), i.e. stationary phase, mobile phase composition and injection solvent nature. The experiments were performed considering two groups of antimalarial molecules: one group with neutral/apolar compounds and the other one with salt form of polar compounds. In this context, another objective was to propose a suitable sample solvent for quantitative analysis. The interest of new generation stationary phase to obtain good peak shape and the interest to tune the mobile phase composition were demonstrated. During this study, design of experiments and desirability function approach enabled to highlight optimal chromatographic conditions in order to maximise peak capacity and to get acceptable value of symmetry factor. Regarding sample injection solvent composition, some counterintuitive results were observed: solvents closer to the mobile phase polarity (i.e heptane or 2-propanol/heptane mixture) did not provide best results in terms of peak symmetry. In addition, acetonitrile and short aliphatic alcohols offered an interesting alternative as injection solvent: toxicity of solvents used is clearly reduced and better quantitative performances could be expected while keeping high peak capacity and symmetric sharp peaks. Finally, the quantitative performances were evaluated by the method validation for the quantitative determination of quinine sulfate in a pharmaceutical formulation. These better understandings on critical method parameters led SFC to be an even more promising technique in the field of the analysis of pharmaceutical compounds. [less ▲]

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See detailLaboratory idenification of anaerobic bacteria isolated on Clostridium difficile selective medium
Rodriguez Diaz, Cristina ULg; Warszawski, Nathalie; Korsak Koulagenko, Nicolas ULg et al

in Acta Microbiologica et Immunologica Hungarica (2016)

Despite increasing interest in the bacterium, the methodology for Clostridium difficile recovery has not yet been standardised. Cycloserine cefoxitin fructose taurocholate (CCFT) has historically been the ... [more ▼]

Despite increasing interest in the bacterium, the methodology for Clostridium difficile recovery has not yet been standardised. Cycloserine cefoxitin fructose taurocholate (CCFT) has historically been the most used medium for C. difficile isolation from human, animal, environmental and food samples, and presumptive identification is usually based on colony morphologies. However, CCFT is not totally selective. This study describes the recovery of 24 bacteria species belonging to 10 different genera other than C. difficile, present in the environment and foods of a retirement establishment that were not inhibited in the C. difficile selective medium. These findings provide insight for further environmental and food studies as well as for isolation of C. difficile on supplemented CCFT. [less ▲]

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See detailAn Exact Method for Designing Shewhart X ̅ and S2 Control Charts to Guarantee the In-Control Performance
Faraz, Alireza ULg; Heuchenne, Cédric ULg

in Journal of Quality Technology (2016)

The in-control performance of the Shewhart X ̅ and S2 control charts with estimated in-control parameters has been evaluated by a number of authors. Results indicate an unrealistically large amount of ... [more ▼]

The in-control performance of the Shewhart X ̅ and S2 control charts with estimated in-control parameters has been evaluated by a number of authors. Results indicate an unrealistically large amount of Phase I data is needed to have the desired in-control average run length (ARL) value in Phase II. To overcome this problem, it has been recommended that the control limits be adjusted based on a bootstrap method to guarantee that the in-control ARL is at least a specified value with a certain specified probability. In our paper we present simple formulas for the required control limits so that practitioners do not have to use the bootstrap method. An assumption of normality is required. The advantage of our proposed method is in its simplicity; there is no bootstrapping and the control chart constants do not depend on the Phase I sample data. [less ▲]

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See detailDoes sector-specific experience matter? The case of European higher education ministers
Jacqmin, Julien ULg; Lefebvre, Mathieu ULg

in Research Policy (2016), 45(5), 987998

This paper looks at the relationship between higher education ministers and the performance of the sector that they govern. Using an original panel dataset with the characteristics of European higher ... [more ▼]

This paper looks at the relationship between higher education ministers and the performance of the sector that they govern. Using an original panel dataset with the characteristics of European higher education ministers, we find that having a past experience in the sector leads to a higher level of performance, as measured by ranking data. Making a parallel with the literature about the impact of education on the educated, we discuss potential explanations behind the impact of this on-the-job learning experience. As we find that this characteristic has no impact on the spendings of the sector, we argue that this academic experience makes them more prone to introduce adequate reforms that makes the sector more attractive for top-researchers. Furthermore, we find that this result is driven by ministers with both sector-specific and electoral experience, the latter measured by a successful election at the regional or national level. This tends to show that political credibility should not be overshadowed by the importance of the sector-specific experience of ministers. [less ▲]

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See detailExplaining the diversity of motivations behind community renewable energy
Bauwens, Thomas ULg

in Energy Policy (2016), 93

Community-based renewable energy initiatives may be important actors in the transition toward low-carbon energy systems. In turn, stimulating investments in renewable energy production at the community ... [more ▼]

Community-based renewable energy initiatives may be important actors in the transition toward low-carbon energy systems. In turn, stimulating investments in renewable energy production at the community level requires a better understanding of investors’ motives. This paper aims to study the heterogeneity of motivations that drive individuals to participate in community renewable energy projects and the underlying explanatory factors behind this, as well as the implications for their level of engagement in initiatives. Based on quantitative data from an original survey conducted with two renewable energy cooperatives in Flanders, the statistical analysis shows that cooperative members should not be considered as one homogeneous group. Several categories of members with different motives and levels of engagement can be distinguished. This heterogeneity is explained by contrasts in terms of institutional settings, spatial patterns and attitudes to the diffusion of institutional innovations. Regarding policy implications, the findings suggest that this heterogeneity should be taken into account in designing more effective supporting policies to stimulate investments at the community level. The activation of social norms is also shown to be a promising mechanism for triggering investment decisions, although the implications of its interplay with economic incentives should be further explored. [less ▲]

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See detailCarbon xerogels as model materials: toward a relationship between pore texture and electrochemical behavior as anodes for lithium-ion batteries
Piedboeuf, Marie-Laure ULg; Léonard, Alexandre ULg; Deschamps, Fabien ULg et al

in Journal of Materials Science (2016), 51(9), 4358-4370

The mechanisms of Li+ insertion in porous hard carbons used as anodes for Li-ion batteries are still a matter of debate, especially considering the divergence of electrochemical performances observed in ... [more ▼]

The mechanisms of Li+ insertion in porous hard carbons used as anodes for Li-ion batteries are still a matter of debate, especially considering the divergence of electrochemical performances observed in literature. Since these materials usually exhibit several levels of porosity, the pore texture vs. electrochemical behavior relationship is difficult to establish. In this paper, we propose to use carbon xerogels, prepared from aqueous resorcinol-formaldehyde mixtures, as model materials for Li-ion battery anodes to study the influence of the pore texture on the overall electrochemical behavior. Indeed, carbon xerogels are described as microporous nodules linked together to form meso- or macroporous voids inside a 3D gel structure; the size of these voids can be tuned by changing the synthesis conditions without affecting other parameters such as the micropore volume. The materials are chosen so as to obtain identical average particle sizes, homogeneous coatings with similar thicknesses and a comparable surface chemistry. The electrochemical behavior of carbon xerogels as Li-ion anodes are correlated with the surface accessible to the electrolyte and are not dependent on the total specific surface area calculated by the BET method from nitrogen adsorption isotherms. The key parameter proposed to understand their behavior is the external surface area of the nodules, which corresponds to the surface of the meso/macropores. [less ▲]

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See detailReflexive Loops on Scaling issues in Landscape Quality Assessment
Schmitz, Serge ULg; Vanderheyden, Vincent ULg

in Land Use Policy (2016), 53

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See detailTrophic plasticity of Antarctic echinoids under contrasted environmental conditions
Michel, Loïc ULg; David, Bruno; Dubois, Philippe et al

in Polar Biology (2016), 39(5), 913-923

Echinoids are common members of Antarctic zoobenthos, and different groups can show important trophic diversity. As part of the ANT-XXIX/3 cruise of RV Polarstern, trophic plasticity of sea urchins was ... [more ▼]

Echinoids are common members of Antarctic zoobenthos, and different groups can show important trophic diversity. As part of the ANT-XXIX/3 cruise of RV Polarstern, trophic plasticity of sea urchins was studied in three neighbouring regions (Drake Passage, Bransfield Strait and Weddell Sea) featuring several depth-related habitats offering different trophic environments to benthic consumers. Three families with contrasting feeding habits (Cidaridae, Echinidae and Schizasteridae) were studied. Gut content examination and stable isotopes ratios of C and N suggest that each of the studied families showed a different response to variation in environmental and food conditions. Schizasteridae trophic plasticity was low, and these sea urchins were bulk sediment feeders relying on sediment-associated organic matter in all regions and/or depth-related habitats. Cidaridae consumed the most animal-derived material. Their diet varied according to the considered area, as sea urchins from Bransfield Strait relied mostly on living and/or dead animal material, while specimens from Weddell Sea fed on a mixture of dead animal material and other detritus. Echinidae also showed important trophic plasticity. They fed on various detrital items in Bransfield Strait, and selectivity of ingested material varied across depth-related habitats. In Weddell Sea, stable isotopes revealed that they mostly relied on highly 13C-enriched food items, presumably microbially-reworked benthic detritus. The differences in adaptive strategies could lead to family-specific responses of Antarctic echinoids to environmental and food-related changes. [less ▲]

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See detailCystatin C standardization decreases assay variation and improves assessment of glomerular filtration rate
Ebert, N; DELANAYE, Pierre ULg; Shlipak, M et al

in Clinica Chimica Acta (2016), 456

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See detailL’institutionnalisation du droit international (1869-1873). Les réseaux internationaux de Gustave Rolin-Jaequemyns
Genin, Vincent ULg

in Journal of the History of International Law / Revue d'Histoire du Droit International (2016), 18(2-3), 181-196

This article deals with a phenomenon which appears in a particular context: the institutionalisation of international law between 1869 (creation of the Revue de droit international et de législation ... [more ▼]

This article deals with a phenomenon which appears in a particular context: the institutionalisation of international law between 1869 (creation of the Revue de droit international et de législation comparée) and 1873 (birth of the Institut de Droit International), through the international networks of the Belgian lawyer Gustave Rolin-Jaequemyns. He was close to Pasquale Mancini, John Westlake, James Lorimer, Franz Von Holtzendorff, but also to the least-known Michael Corr-Van der Maeren, a publicist. Until this period of crystallisation this field was not structured and represented an aggregate of individualities. What can we say about such a process of institutionalisation on the basis of unpublished archives? The history of international law, until today, especially studied by lawyers, was very neglected by historians, whose methods and sources are complementary to those of the lawyer. Our contribution wishes to contribute to the development of a history of international law written by historians. [less ▲]

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See detailCross-cultural adaptation and validation of the VISA-P questionnaire for French-speaking patients with patellar tendinopathy
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Journal of Orthopaedic & Sports Physical Therapy (2016), 46(5), 384-393

Study Design Clinical measurement study. Background The Victorian Institute of Sports Assessment–Patellar tendinopathy questionnaire (VISA-P), originally developed in English, assesses the severity of ... [more ▼]

Study Design Clinical measurement study. Background The Victorian Institute of Sports Assessment–Patellar tendinopathy questionnaire (VISA-P), originally developed in English, assesses the severity of patellar tendinopathy symptoms. No French version of the questionnaire exists. Objectives The aim of our study was to translate the VISA-P in French and verify its psychometric properties. Methods The translation and cultural adaptation were performed according to international recommendations in six steps: initial translation, translation merging, back translation to the original language, expert committee to reach a pre-final version, test of the pre-final version, and expert committee appraisal of a final version. Afterwards, the psychometric properties the final French version (VISA-PF) were assessed in 92 subjects, divided into three groups: pathological subjects (n = 28), asymptomatic subjects (n = 22) and sports-risk subjects (n = 42). Results All members of the expert committee agreed with the final version. On a scale ranging from 0 to 100 (asymptomatic subject), the average scores of the VISA-PF obtained were 53 (± 17) for the pathological group, 99 (± 2) for the healthy group and 86 (± 14) for the sports-risk group. The test-retest reliability of the VISA-PF was excellent and good internal consistency. Correlations between the VISA-PF and diverging validity of the SF-36 were low and the correlation coefficient values measured between the VISA-PF scores and converged items of the SF-36 were higher. Conclusion The VISA-PF is understandable, valid and suitable for French-speaking patients with patellar tendinopathy. [less ▲]

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See detailDeveloping Tourism Products and new Partnerships through Participative Action Research in Rural Cameroon
Schmitz, Serge ULg; Lekane Tsoubgou, Dieudonné

in Geographical Research (2016), 54(2), 143-152

The paper explores possible synergies between microfinance institutions and small and medium medium tourism businesses in the West Cameron Chiefdooms. Based on a research action the authors emphasise the ... [more ▼]

The paper explores possible synergies between microfinance institutions and small and medium medium tourism businesses in the West Cameron Chiefdooms. Based on a research action the authors emphasise the obstacles to the formation of partnership and describe how the researchers facilitated networking. [less ▲]

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See detailNonbelieved memories in middle-aged and older adults
Brédart, Serge ULg; Bouffier, Marion

in Consciousness & Cognition (2016), 42(2), 352-357

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See detailUnderground pumped storage hydroelectricity using abandoned works (deep mines or open pits) and the impact on groundwater flow
Pujades, Estanislao ULg; Willems, Thibault ULg; Bodeux, Sarah ULg et al

in Hydrogeology Journal (2016)

Underground pumped storage hydroelectricity (UPSH) plants using open-pit or deep mines can be used in flat regions to store the excess of electricity produced during low-demand energy periods. It is ... [more ▼]

Underground pumped storage hydroelectricity (UPSH) plants using open-pit or deep mines can be used in flat regions to store the excess of electricity produced during low-demand energy periods. It is essential to consider the interaction between UPSH plants and the surrounding geological media. There has been little work on the assessment of associated groundwater flow impacts. The impacts on groundwater flow are determined numerically using a simplified numerical model which is assumed to be representative of open-pit and deep mines. The main impact consists of oscillation of the piezometric head, and its magnitude depends on the characteristics of the aquifer/geological medium, the mine and the pumping and injection intervals. If an average piezometric head is considered, it drops at early times after the start of the UPSH plant activity and then recovers progressively. The most favorable hydrogeological conditions to minimize impacts are evaluated by comparing several scenarios. The impact magnitude will be lower in geological media with low hydraulic diffusivity; however, the parameter that plays the more important role is the volume of water stored in the mine. Its variation modifies considerably the groundwater flow impacts. Finally, the problem is studied analytically and some solutions are proposed to approximate the impacts, allowing a quick screening of favorable locations for future UPSH plants. [less ▲]

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See detailTropospheric water vapour isotopologue data (H216O, H218O and HD16O) as obtained from NDACC/FTIR solar absorption spectra
Barthlott, Sabine; Schneider, Matthias; Hase, Frank et al

in Earth System Science Data Discussions (2016)

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the ... [more ▼]

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the Detection of Atmospheric Composition Change; ftp://ftp.cpc.ncep.noaa.gov/ndacc/MUSICA/) and via doi:10.5281/zenodo.48902. Currently, data are available for 12 globally distributed stations. They have been centrally retrieved and quality filtered in the framework of the MUSICA project (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water). We explain particularities of retrieving the water vapour isotopologue state (vertical distribution of H162O, H182O and HD16O) and reveal the need for a new meta-data template for archiving such FTIR isotopologue data. We describe the format of different data components and give recommendations for correct data usage. Data are provided as two data types. The first type is best-suited for tropospheric water vapour distribution studies disregarding different isotopologues (comparison with radiosonde data, analyses of water vapour variability and trends, etc.). The second type is needed for analysing moisture pathways by means of {H2O,delta-D}-pair distributions. [less ▲]

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See detailNovel approaches for preventing acute graftversus- host disease after allogeneic hematopoietic stem cell transplantation
SERVAIS, Sophie ULg; BEGUIN, Yves ULg; Delens, Loïc ULg et al

in Expert Opinion on Investigational Drugs (2016)

Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers potential curative treatment for a wide range of malignant and nonmalignant hematological disorders. However, its success ... [more ▼]

Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) offers potential curative treatment for a wide range of malignant and nonmalignant hematological disorders. However, its success may be limited by post-transplant acute graft-versus-host disease (aGVHD), a systemic syndrome in which donor’s immune cells attack healthy tissues in the immunocompromised host. aGVHD is one of the main causes of morbidity and mortality after alloHSCT. Despite standard GVHD prophylaxis regimens, aGVHD still develops in approximately 40–60% of alloHSCT recipients. Areas covered In this review, after a brief summary of current knowledge on the pathogenesis of aGVHD, the authors review the current combination of a calcineurin inhibitor with an antimetabolite with or without added anti-thymocyte globulin (ATG) and emerging strategies for GVHD prevention. Expert opinion A new understanding of the involvement of cytokines, intracellular signaling pathways, epigenetics and immunoregulatory cells in GVHD pathogenesis will lead to new standards for aGVHD prophylaxis allowing better prevention of severe aGVHD without affecting graft-versus-tumor effects. [less ▲]

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See detailFrom Near-Infrared and Raman to Surface-Enhanced Raman Spectroscopy: Progress, Limitations, Perspectives in Bioanalysis
Dumont, Elodie ULg; De Bleye, Charlotte ULg; Sacre, Pierre-Yves ULg et al

in Bioanalysis (2016), 8(10), 1077-1103

Over recent decades, spreading environmental concern entailed the expansion of green chemistry analytical tools. Vibrational spectroscopy, belonging to this class of analytical tool, is particularly ... [more ▼]

Over recent decades, spreading environmental concern entailed the expansion of green chemistry analytical tools. Vibrational spectroscopy, belonging to this class of analytical tool, is particularly interesting taking into account its numerous advantages such as fast data acquisition and no sample preparation. In this context, Near-Infrared, Raman and mainly Surface-Enhanced Raman Spectroscopy (SERS) have thus gained interest in many fields including bioanalysis. The two former techniques only ensure the analysis of concentrated compounds in simple matrices, whereas the emergence of SERS improved the performances of vibrational spectroscopy to very sensitive and selective analyses. Complex SERS substrates were also developed enabling biomarker measurements, paving the way for SERS immunoassays. Therefore, in this paper, the strengths and weaknesses of these techniques will be highlighted with a focus on recent progress. [less ▲]

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See detailFire Fragility Curves for Steel Buildings in a Community Context: A Methodology
Gernay, Thomas ULg; Elhami Khorasani, Negar; Garlock, Maria

in Engineering Structures (2016), 113

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to ... [more ▼]

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to characterize the probabilistic vulnerability of steel buildings to fire in the context of community resilience assessment. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response are considered. In addition several fire scenarios at different locations in the building are studied. Monte Carlo Simulations and Latin Hypercube Sampling are used to generate the probability distributions of demand placed on the members and structural capacity relative to selected damage thresholds. By assessing demand and capacity in the temperature domain, the thermal and the structural problems can be treated separately to improve the efficiency of the probabilistic analysis. After the probability distributions are obtained for demand and capacity, the fragility functions can be obtained by convolution of the distributions. Finally, event tree analysis is used to combine the functions associated with fire scenarios in different building locations. The developed fire fragility functions yield the probability of exceedance of predefined damage states as a function of the fire load in the building. The methodology is illustrated on an example consisting in a prototype nine-story steel building based on the SAC project. [less ▲]

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See detailDirect one-pot synthesis of poly(ionic liquid) nanogels by cobalt-mediated radical cross-linking copolymerization in organic or aqueous media
Weiss-Maurin, Mathilde ULg; Cordella, Daniela ULg; Jérôme, Christine ULg et al

in Polymer Chemistry (2016), 7(14), 2521-2530

Nanogels of controlled kinetic chain length were synthesized by cobalt-mediated radical cross-linking copolymerization (CMRccP) involving a vinyl monomer and a divinyl cross-linker. This strategy was ... [more ▼]

Nanogels of controlled kinetic chain length were synthesized by cobalt-mediated radical cross-linking copolymerization (CMRccP) involving a vinyl monomer and a divinyl cross-linker. This strategy was first validated to achieve neutral poly(vinyl acetate) nanogels by CMRccP of vinyl acetate and divinyl adipate as cross-linker, at 40 °C, in presence of an alkyl- cobalt(III) serving both as initiator and controlling agent, using ethyl acetate as solvent. Poly(ionic liquid) nanogels were then directly obtained by CMRccP of N-vinyl-3-ethyl imidazolium bromide, in presence of 1,13-divinyl-3-decyl diimidazolium bromide as cross-linker. CMRccP experiments could be conducted either in organic solvent using dimethyl formamide or, more interestingly, in aqueous solution, demonstrating the robustness and the versatility of this one-step process. Chain extensions of PILs nanogels were also carried out in water, forming core-shell structures, thus opening new avenues in the design of functional nanogels. [less ▲]

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See detailNew 2016 MeSH addressing information gap, poverty, violence and danger of medicine set the tone for policy makers in patient care
Jamoulle, Marc ULg

in International Journal of Health Policy and Management (2016)

A careful review of the list of newly published Medical subject Heading in 2016 allows to identify 52 new or updated MESH in 2016 relevant to General Practice Family Medicine management (i.e. non-clinical ... [more ▼]

A careful review of the list of newly published Medical subject Heading in 2016 allows to identify 52 new or updated MESH in 2016 relevant to General Practice Family Medicine management (i.e. non-clinical) fields. Information society gap, poverty, violence and quaternary prevention related MeSH are outstandingly frequent. The 52 identified MeSH are proposed in supplementary material. [less ▲]

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See detailLow-rank plus sparse decomposition for exoplanet detection in direct-imaging ADI sequences. The LLSG algorithm
Gómez González, Carlos ULg; Absil, Olivier ULg; Absil, P.-A. et al

in Astronomy and Astrophysics (2016), 589

Context. Data processing constitutes a critical component of high-contrast exoplanet imaging. Its role is almost as important as the choice of a coronagraph or a wavefront control system, and it is ... [more ▼]

Context. Data processing constitutes a critical component of high-contrast exoplanet imaging. Its role is almost as important as the choice of a coronagraph or a wavefront control system, and it is intertwined with the chosen observing strategy. Among the data processing techniques for angular differential imaging (ADI), the most recent is the family of principal component analysis (PCA) based algorithms. It is a widely used statistical tool developed during the first half of the past century. PCA serves, in this case, as a subspace projection technique for constructing a reference point spread function (PSF) that can be subtracted from the science data for boosting the detectability of potential companions present in the data. Unfortunately, when building this reference PSF from the science data itself, PCA comes with certain limitations such as the sensitivity of the lower dimensional orthogonal subspace to non-Gaussian noise. <BR /> Aims: Inspired by recent advances in machine learning algorithms such as robust PCA, we aim to propose a localized subspace projection technique that surpasses current PCA-based post-processing algorithms in terms of the detectability of companions at near real-time speed, a quality that will be useful for future direct imaging surveys. <BR /> Methods: We used randomized low-rank approximation methods recently proposed in the machine learning literature, coupled with entry-wise thresholding to decompose an ADI image sequence locally into low-rank, sparse, and Gaussian noise components (LLSG). This local three-term decomposition separates the starlight and the associated speckle noise from the planetary signal, which mostly remains in the sparse term. We tested the performance of our new algorithm on a long ADI sequence obtained on β Pictoris with VLT/NACO. <BR /> Results: Compared to a standard PCA approach, LLSG decomposition reaches a higher signal-to-noise ratio and has an overall better performance in the receiver operating characteristic space. This three-term decomposition brings a detectability boost compared to the full-frame standard PCA approach, especially in the small inner working angle region where complex speckle noise prevents PCA from discerning true companions from noise. [less ▲]

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See detailAnthropogenic forcing dominates global mean sea-level rise since 1970
Slagen, A.; Church, J.; Agosta, Cécile ULg et al

in Nature Climate Change (2016)

Sea-level change is an important consequence of anthropogenic climate change, as higher sea levels increase the frequency of sea-level extremes and the impact of coastal flooding and erosion on the ... [more ▼]

Sea-level change is an important consequence of anthropogenic climate change, as higher sea levels increase the frequency of sea-level extremes and the impact of coastal flooding and erosion on the coastal environment, infrastructure and coastal communities1, 2. Although individual attribution studies have been done for ocean thermal expansion3, 4 and glacier mass loss5, two of the largest contributors to twentieth-century sea-level rise, this has not been done for the other contributors or total global mean sea-level change (GMSLC). Here, we evaluate the influence of greenhouse gases (GHGs), anthropogenic aerosols, natural radiative forcings and internal climate variability on sea-level contributions of ocean thermal expansion, glaciers, ice-sheet surface mass balance and total GMSLC. For each contribution, dedicated models are forced with results from the Coupled Model Intercomparison Project Phase 5 (CMIP5) climate model archive6. The sum of all included contributions explains 74 ± 22% (±2σ) of the observed GMSLC over the period 1900–2005. The natural radiative forcing makes essentially zero contribution over the twentieth century (2 ± 15% over the period 1900–2005), but combined with the response to past climatic variations explains 67 ± 23% of the observed rise before 1950 and only 9 ± 18% after 1970 (38 ± 12% over the period 1900–2005). In contrast, the anthropogenic forcing (primarily a balance between a positive sea-level contribution from GHGs and a partially offsetting component from anthropogenic aerosols) explains only 15 ± 55% of the observations before 1950, but increases to become the dominant contribution to sea-level rise after 1970 (69 ± 31%), reaching 72 ± 39% in 2000 (37 ± 38% over the period 1900–2005). [less ▲]

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See detailCO2-blown microcellular non-isocyanate polyurethane (NIPU) foams: from bio- and CO2-sourced monomers to potentially thermal insulating materials
Grignard, Bruno ULg; Thomassin, Jean-Michel ULg; Gennen, Sandro ULg et al

in Green Chemistry (2016), 18(7), 2206-2215

Bio- and CO2-sourced non-isocyanate polyurethane (NIPU) microcellular foams were prepared using supercritical carbon dioxide (scCO2) foaming technology. These low-density foams offer low thermal ... [more ▼]

Bio- and CO2-sourced non-isocyanate polyurethane (NIPU) microcellular foams were prepared using supercritical carbon dioxide (scCO2) foaming technology. These low-density foams offer low thermal conductivity and have an impressive potential for use in insulating materials. They constitute attractive alternatives to conventional polyurethane foams. We investigated CO2’s ability to synthesize the cyclic carbonates that are used in the preparation of NIPU by melt step-growth polymerization with a bio-sourced amino-telechelic oligoamide and for NIPU foaming. Our study shows that CO2 is not only sequestered in the material for long-term application, but is also valorized as a blowing agent in the production of NIPU foams. Such foams will contribute to energy conservation and savings by reducing CO2 emissions. [less ▲]

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See detailEvaluating ethane and methane emissions associated with the development of oil and natural gas extraction in North America
Franco, Bruno ULg; Mahieu, Emmanuel ULg; Emmons, L. K. et al

in Environmental Research Letters (2016), 11(4), 044010

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight ... [more ▼]

Sharp rises in the atmospheric abundance of ethane (C2H6) have been detected from 2009 onwards in the Northern Hemisphere as a result of the unprecedented growth in the exploitation of shale gas and tight oil reservoirs in North America. Using time series of C2H6 total columns derived from ground-based FTIR observations made at five selected NDACC sites, we characterize the recent C2H6 evolution and determine growth rates of ~5%/yr at mid-latitudes and of ~3%/yr at remote sites. Results from CAM-chem simulations with the HTAP2 bottom-up inventory for anthropogenic emissions are found to greatly underestimate the current C2H6 abundances. Doubling global emissions is required to reconcile the simulations and the observations prior to 2009. We further estimate that North American anthropogenic C2H6 emissions have increased from 1.6 Tg/yr in 2008 to 2.8 Tg/yr in 2014, i.e. by 75% over these six years. We also completed a second simulation with new top-down emissions of C2H6 from North American oil and gas activities, biofuel consumption and biomass burning, inferred from space-borne observations of methane (CH4) from GOSAT. In this simulation, GEOS-Chem is able to reproduce FTIR measurements at the mid-latitudinal sites, underscoring the impact of the North American oil and gas development on the current C2H6 abundance. Finally we estimate that the North American oil and gas emissions of CH4, a major greenhouse gas, grew from 20 to 35 Tg/yr over the period 2008 to 2014, in association with the recent C2H6 rise. [less ▲]

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See detailReconstruction and analysis of long-term satellite-derived sea surface temperature for the South China Sea
Huynh, Thi Hong Ngu ULg; Alvera Azcarate, Aïda ULg; Barth, Alexander ULg et al

in Journal of Oceanography (2016)

Sea surface temperature (SST) is one of the key variables often used to investigate ocean dynamics, ocean-atmosphere interaction, and climate change. Unfortunately, the SST data sources in the South China ... [more ▼]

Sea surface temperature (SST) is one of the key variables often used to investigate ocean dynamics, ocean-atmosphere interaction, and climate change. Unfortunately, the SST data sources in the South China Sea (SCS) are not abundant due to sparse measurements of in situ SST and a high percentage of missing data in the satellite-derived SST. Therefore, SST data sets with low resolution and/or a short-term period have often been used in previous researches. Here we used Data INterpolating Empirical Orthogonal Functions, a self-consistent and parameter-free method for filling in missing data, to reconstruct the daily nighttime 4-km AVHRR Pathfinder SST for the long-term period spanning from 1989 to 2009. In addition to the reconstructed field, we also estimated the local error map for each reconstructed image. Comparisons between the reconstructed and other data sets (satellite-derived microwave and in situ SSTs) show that the results are reliable for use in many different researches, such as validating numerical models, or identifying and tracking meso-scale oceanic features. Moreover, the Empirical Orthogonal Function (EOF) analysis of the reconstructed SST and the reconstructed SST anomalies clearly shows the subseasonal, seasonal, and interannual variability of SST under the influence of monsoon and El Niño-Southern Oscillation (ENSO), as well as reveals some oceanic features that could not be captured well in previous EOF analyses. The SCS SST often lags ENSO by about half a year. However, in this study, we see that the time lag changes with the frequencies of the SST variability, from 1 to 6 months. [less ▲]

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See detailDevelopment of solid-supported methodology for the preparation of peptidoglycan fragments containing (2S,6R)-diaminopimelic acid
Simon, Justine ULg; Lamborelle, Nicolas ULg; Zervosen, Astrid et al

in Tetrahedron Letters (2016)

Herein, we describe the development of an efficient solid-supported methodology for the stereoselective synthesis of two peptides containing (2S,6R)-diaminopimelic acid, (S)-Ala-γ-(R)-Glu-(2S,6R)-A2pm-(R ... [more ▼]

Herein, we describe the development of an efficient solid-supported methodology for the stereoselective synthesis of two peptides containing (2S,6R)-diaminopimelic acid, (S)-Ala-γ-(R)-Glu-(2S,6R)-A2pm-(R)-Ala 1 and γ-(R)-Glu-(2S,6R)-A2pm 2. The platform consists of a Wang resin anchored by an amino acid chain including allylglycine. By olefin cross metathesis with vinylglycine, unsaturated protected (2S,6R)-A2pm was fixed on solid support. Peptides were achieved by cleavage of cross metathesis products from resin, followed by reduction of double bonds along removing of protecting groups. Furthermore, this efficient solid phase approach will lead to peptide and muropeptide libraries. [less ▲]

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See detailEnrichment of Central African logged forests with high-value tree species: testing a new approach to regenerating degraded forests
Doucet, Jean-Louis ULg; Daïnou, Kasso ULg; Ligot, Gauthier ULg et al

in International Journal of Biodiversity Science, Ecosystem Services and Management (2016)

In natural forests of Central Africa, several studies indicate a dramatic decrease in commercial trees, including species of concern for conservation. Enrichment planting with these species will favor ... [more ▼]

In natural forests of Central Africa, several studies indicate a dramatic decrease in commercial trees, including species of concern for conservation. Enrichment planting with these species will favor both the long-term recovery of their populations and biodiversity conservation in logged forests. In this study, we analyzed the survival and growth of 23 species in plantations. Fourteen 0.2–1.1 ha mixed species plantations consisting of single-species 15 × 15 m blocks were studied for 5 years in a logging concession of southeastern Cameroon. The plantation design considered both species light requirements and sensitivity to damage by pests. To identify the best species for enrichment planting, we assessed both species performance and plantation costs. We also tested for relationships between species traits and species performance. Mean annual diameter growth increments ranged from 1.67 to 42.9 mm. No significant relationship was found between growth and survival. Herbivory by wild Bovidae was the main cause of mortality and should be carefully considered in rehabilitation efforts. We found a significant negative relationship between wood density and maximum growth rate. The other traits tested were not good predictors of species performance in plantations. The two best-performing species, Triplochiton scleroxylon and Terminalia superba, could reach the minimum cutting diameter during a 30-year cutting cycle. Costs were high and mechanized site preparation is suggested to reduce them. Widespread adoption of such plantations will only occur if financial incentives or national regulations for assuring regeneration are implemented. [less ▲]

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See detailAs above, so below? Narrative Salience and Side Effects of National Innovation Systems
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Critical Policy Studies (2016)

This article furthers previous attempts at integrating narratology in policy analysis. Embracing an open-ended definition of narrative, it stresses the importance of maintaining distinct narrative levels ... [more ▼]

This article furthers previous attempts at integrating narratology in policy analysis. Embracing an open-ended definition of narrative, it stresses the importance of maintaining distinct narrative levels and, more generally, of taking into account the pragmatic dimension of narration as an activity, including the often-implicit role and focalization of the policy analyst. Developing a conceptual analogy between storytelling and the exercise of power, it argues for a critical use of practical imagination in ‘cold’ situations of ‘narrative salience’, characterized by the absence of controversy or uncertainty, an uneven distribution of the power of scenarization. These propositions for a ‘revisited’ approach to policy narratives, equidistant from the positivist and post-positivist dichotomy, are tested on the case of ‘narrative salience’ where a particular storyline, national innovation systems, is so dominant that there appears to be no ‘counter-story’. [less ▲]

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See detailObservational signatures of past mass-exchange episodes in massive binaries: The case of HD 149 404
Raucq, Françoise ULg; Rauw, Gregor ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics (2016), 588

Context. Mass and momentum exchanges in close massive binaries play an important role in their evolution, and produce several observational signatures such as asynchronous rotation and altered chemical ... [more ▼]

Context. Mass and momentum exchanges in close massive binaries play an important role in their evolution, and produce several observational signatures such as asynchronous rotation and altered chemical compositions, that remain after the stars detach again. Aims: We investigated these effects for the detached massive O-star binary HD 149 404 (O7.5 If + ON9.7 I, P = 9.81 days), which is thought to have experienced a past episode of case A Roche-lobe overflow (RLOF). Methods: Using phase-resolved spectroscopy, we performed the disentangling of the optical spectra of the two stars. The reconstructed primary and secondary spectra were then analysed with the CMFGEN model atmosphere code to determine stellar parameters, such as the effective temperatures and surface gravities, and to constrain the chemical composition of the components. We complemented the optical study with the study of IUE spectra, which we compare to the synthetic binary spectra. The properties of the stars were compared to evolutionary models. Results: We confirmed a strong overabundance in nitrogen ([N/C] ~ 150[N/C][SUB]⊙[/SUB]) for the secondary and a slight nitrogen overabundance ([N/C] ~ 5[N/C][SUB]⊙[/SUB]) for the primary star. Comparing the two stars, we found evidence for asynchronous rotation, with a rotational period ratio of 0.50 ± 0.11. Conclusions: The hypothesis of a past case A RLOF interaction in HD 149 404 is most plausible to explain its chemical abundances and rotational asynchronicity. Some of the observed properties, such as the abundance pattern, are clearly a challenge for current case A binary evolution models, however. [less ▲]

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See detailSoil apparent conductivity measurements for planning and analysis of agricultural experiments: A case study from Western-Thailand
Rudolph, Sebastian; Wongleecharoen, Chalemchart; Lark, Murray et al

in Geoderma (2016), 267

In experimental trials, the success or failure of agricultural improvements is commonly evaluated on the agronomic response of crops, using proper experimental designs with sufficient statistical power ... [more ▼]

In experimental trials, the success or failure of agricultural improvements is commonly evaluated on the agronomic response of crops, using proper experimental designs with sufficient statistical power. Since fine-scale variability of the experimental site can reduce statistical power, efficiency gains in the experimental design can be achieved if this variation is known and used to design blocking, or some proxy variable is used as a covariate. Near-surface geophysical techniques such as electromagnetic induction (EMI), which describes subsurface properties non-invasively by measuring soil apparent conductivity (ECa), may be one source of this information. The motivation of our study was to investigate the effectiveness of EMI-derived ECa measurements for planning and analysis of agricultural experiments. ECa and plant height measurements (the response variable) were taken from an agroforestry experiment in Western Thailand, and their variability was quantified to simulate multiple realizations of ECa and the residuals of the response variable from treatment means. These were combined to produce simulated data from different experimental designs and treatment effects. The simulated data were then used to evaluate the statistical power by detecting three orthogonal contrasts among the treatments in the original experiment. We considered three experimental designs, a simple random design (SR), a complete randomized block design (CRB), and a complete randomized block design with spatially adjusted blocks on plot means of ECa (CRBECa). Using analysis of variance (ANOVA), the smallest effect sizes could be detected with the CRBECa design, which indicates that ECa measurements could be used in the planning phase of an experiment to achieve efficiencies by improved blocking. In contrast, analysis of covariance (ANCOVA) demonstrated that substantial power improvements could be gained when ECa was considered as a covariate in the analysis. We therefore recommend that ECa measurements should be used to characterize subsurface variability of experimental sites and to support the statistical analysis of agricultural experiments. [less ▲]

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See detailHerschel observations of the nebula M1-67 around the Wolf-Rayet star WR 124
Vamvatira-Nakou, C.; Hutsemekers, Damien ULg; Royer, P. et al

in Astronomy and Astrophysics (2016), 588

Infrared Herschel imaging and spectroscopic observations of the nebula M1-67 around the Wolf-Rayet star WR 124 have been obtained along with optical imaging observations. The infrared images reveal a ... [more ▼]

Infrared Herschel imaging and spectroscopic observations of the nebula M1-67 around the Wolf-Rayet star WR 124 have been obtained along with optical imaging observations. The infrared images reveal a clumpy dusty nebula that extends up to 1 pc. The comparison with the optical images shows that the ionized gas nebula coincides with the dust nebula, the dust and the gas being mixed together. A photodissociation region is revealed from the infrared spectroscopic analysis. The analysis of the infrared spectrum of the nebula, where forbidden emission lines of ionized elements were detected, showed that the nebula consists of mildly processed material with the calculated abundance number ratios being N/O = 1.0 ± 0.5 and C/O = 0.46 ± 0.27. Based on a radiative transfer model, the dust mass of the nebula was estimated to be 0.22 M[SUB]⊙[/SUB] with a population of large grains being necessary to reproduce the observations. The comparison of the mass-loss rate and the abundance ratios to theoretical models of stellar evolution led to the conclusion that the nebular ejection took place during a RSG/YSG evolutionary phase of a central star with an initial mass of 32 M[SUB]⊙[/SUB]. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, La Silla, Chile. [less ▲]

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See detailDiscovering novel enzymes y functional screening of plurigenomic libraries from alga-associated Flavobacteriia and Gammaproteobacteria
Martin, Marjolaine ULg; Vandermies, Marie ULg; Joyeux, Coline et al

in Microbiological Research (2016), 186

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with ... [more ▼]

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with originalbiochemistry. We recently isolated several macroalgal-polysaccharide-degrading bacteria from the sur-face of the brown alga Ascophyllum nodosum. These active isolates belong to two classes: the Flavobacteriiaand the Gammaproteobacteria. In the present study, we constructed two “plurigenomic” (with multi-ple bacterial genomes) libraries with the 5 most interesting isolates (regarding their phylogeny andtheir enzymatic activities) of each class (Fv and Gm libraries). Both libraries were screened for diversehydrolytic activities. Five activities, out of the 48 previously identified in the natural polysaccharolyticisolates, were recovered by functional screening: a xylanase (GmXyl7), a beta-glucosidase (GmBg1), anesterase (GmEst7) and two iota-carrageenases (Fvi2.5 and Gmi1.3). We discuss here the potential role ofthe used host-cell, the average DNA insert-sizes and the used restriction enzymes on the divergent screen-ing yields obtained for both libraries and get deeper inside the “great screen anomaly”. Interestingly, thediscovered esterase probably stands for a novel family of homoserine o-acetyltransferase-like-esterases,while the two iota-carrageenases represent new members of the poorly known GH82 family (contain-ing only 19 proteins since its description in 2000). These original results demonstrate the efficiencyof our uncommon “plurigenomic” library approach and the underexplored potential of alga-associatedcultivable microbiota for the identification of novel and algal-specific enzymes. [less ▲]

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See detailLa polykystose rénale autosomique dominante : comment et pourquoi identifier les patients "rapidement progresseurs" vers l'insuffisance rénale terminale?
bodson, aurélie; MEUNIER, Paul ULg; Krzesinski, Jean-Marie ULg et al

in Revue Médicale de Liège (2016), 71(4), 184-192

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients ... [more ▼]

Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterised by the progressive development of multiple and bilateral cysts in kidneys and other organs. Most patients with ADPKD will develop, sooner or later, end-stage renal disease (ESRD). The morbidity and mortality associated with ESRD prompt physicians to identify early ADPKD patients considered as «rapid progressors», who have the greatest risk to rapidly develop ESRD. The rate of progression can be assessed by clinical - especially with the «predicting renal outcome in polycystic kidney disease score» (PROPKD-Score) -, biological (a decline of the glomerular filtration rate (GFR) of 4,4 - 5,9 ml/min/year and/or the doubling of serum creatinine within a 36-month period), or radiological criteria (total kidney volume (TKV) adjusted for the size > 600 cc/m and/or TKV annual growth rate > 5 %). Nowadays, there is no curative treatment for ADPKD. However, vasopressin-2 receptor antagonists, such as tolvaptan, appear to slow down the growth of renal cysts and the slope of GFR decline. The current management of ADPKD patients is mostly based on correcting the risk factors for progression, i.e. encouraging (over)-hydration, normalizing blood pressure, stimulating smoking cessation. [less ▲]

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See detailIntensive enteral nutrition is ineffective for individuals with severe alcoholic hepatitis treated with corticosteroids.
Moreno, C; Deltenre, P; Senterre, C et al

in Gastroenterology (2016), 150

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether ... [more ▼]

BACKGROUND & AIMS: Severe alcoholic hepatitis (AH) is a lifethreatening disease for which adequate oral nutritional support is recommended. We performed a randomized controlled trial to determine whether the combination of corticosteroid and intensive enteral nutrition therapy is more effective than corticosteroid therapy alone in patients with severe AH. METHODS: We enrolled 136 heavy consumers of alcohol (age, 18–75 y) with recent onset of jaundice and biopsy-proven severe AH in our study, performed at 18 hospitals in Belgium and 2 in France, from February 2010 through February 2013. Subjects were assigned randomly (1:1) to groups that received either intensive enteral nutrition plus methylprednisolone or conventional nutrition plus methylprednisolone (controls). In the intensive enteral nutrition group, enteral nutrition was given via feeding tube for 14 days. The primary end point was patient survival for 6 months. RESULTS: In an intention-to-treat analysis, we found no significant difference between groups in 6-month cumulative mortality: 44.4% of patients died in the intensive enteral nutrition group (95% confidence interval [CI], 32.2%–55.9%) and 52.1% of controls died (95% CI, 39.4%– 63.4%) (P ¼ .406). The enteral feeding tube was withdrawn prematurely from 48.5% of patients, and serious adverse events considered to be related to enteral nutrition occurred in 5 patients. Regardless of group, a greater proportion of patients with a daily calorie intake less than 21.5 kcal/kg/day died (65.8%; 95% CI, 48.8–78.4) than patients with a higher intake of calories (33.1%; 95% CI, 23.1%–43.4%) (P < .001). CONCLUSIONS: In a randomized trial of patients with severe AH treated with corticosteroids, we found that intensive enteral nutrition was difficult to implement and did not increase survival. However, low daily energy intake was associated with greater mortality, so adequate nutritional intake should be a main goal for treatment. [less ▲]

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See detailInfluence of a liquid nutritional supplement on water intake in experimental Beagle dogs
Rotat, Christelle; Lhoest, Estelle; Rauw, Anaelle ULg et al

in Open Journal of Veterinary Medicine (2016), 6

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over ... [more ▼]

The objectives were to evaluate the effects of a liquid nutritional supplement formulated for dogs on water intakes and urine output. A liquid nutritional supplement was tested by way of a cross-over design in 8 experimental healthy Beagle dogs (4 males and 4 females, aged 9.3 years). The supplement (87 percent water, 2.7 percent protein, 2.6 percent fat, 0.4 percent crude fiber) was added to water and tested at 2 incorporation rates (50 or 70 ml/day/dog—D50 or D70) versus the control placebo (CO-water only). The dogs were kept in a controlled environment; water intakes and urine output were measured. Individual water intakes were characterised by large variations. Mean water intake increased significantly by 28 percent in dogs receiving the liquid nutritional supplement, in both genders, irrespectively of the dosage. Urine output was also increased, by 55 percent. Faeces scores remained unchanged. It was concluded that the liquid supplement increased water intake and urine output in a safe way, without increasing dramatically the daily dietary sodium chloride intake. The recommended dosage of the manufacturer—50 ml/day for dogs weighing 10 - 20 kg BW is efficient. Increasing the dosage had no advantage, nor adverse effects. Increased water intake and urine output is of interest for dogs suffering from urolithiasis. [less ▲]

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See detailFragmented Territories: Incomplete Enclosures and Agrarian Change on the Agricultural Frontier of Samlaut District, North-West Cambodia
Diepart, Jean-Christophe ULg; Sem, Thol

in Journal of Agrarian Change (2016)

In Cambodia, the interactions between large-scale land investment and land titling gathered particular momentum in 2012–13, when the government initiated an unprecedented upland land titling programme in ... [more ▼]

In Cambodia, the interactions between large-scale land investment and land titling gathered particular momentum in 2012–13, when the government initiated an unprecedented upland land titling programme in an attempt to address land tenure insecurity where large-scale land investment overlaps with land appropriated by peasants. This paper is based on a spatially explicit ethnography of land rights conducted in the Samlaut district of north-west Cambodia – a former Khmer Rouge resistance stronghold – in a context where the enclosures are both incomplete and entangled with post-war, socially embedded land tenure systems. We discuss how this new pattern of fragmentation affects the prevailing dynamics of agrarian change. We argue that it has introduced new forms of exclusion and a generalized perception of land tenure uncertainty that is managed by peasants through the actualization of hybrid land tenure arrangements borrowing from state rules and local consensus. In contrast with common expectations about land formalization, the process reinforces the patterns of social differentiation initiated by land rent capture practices of early migrants and pushes more vulnerable peasants into seeking wage labour and resorting to job migration. [less ▲]

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See detailSelenium in Cattle: A Review
Mehdi, Youcef ULg; Dufrasne, Isabelle ULg

in Molecules (2016), 21(4), 545

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include ... [more ▼]

This review article examines the role of selenium (Se) and the effects of Se supplementation especially in the bovine species. Selenium is an important trace element in cattle. Some of its roles include the participation in the antioxidant defense the cattle farms. The nutritional requirements of Se in cattle are estimated at 100 μg/kg DM (dry matter) for beef cattle and at 300 μg/kg DM for dairy cows. The rations high in fermentable carbohydrates, nitrates, sulfates, calcium or hydrogen cyanide negatively influence the organism’s use of the selenium contained in the diet. The Se supplementation may reduce the incidence of metritis and ovarian cysts during the postpartum period. The increase in fertility when adding Se is attributed to the reduction of the embryonic death during the first month of gestation. A use of organic Se in feed would provide a better transfer of Se in calves relative to mineral Se supplementation. The addition of Se yeasts in the foodstuffs of cows significantly increases the Se content and the percentage of polyunsaturated fatty acids (PUFA) in milk compared to the addition of sodium selenite. The enzyme 5-iodothyronine deiodinase is a seleno-dependent selenoprotein. It is one of the last proteins to be affected in the event of Se deficiency. This delay in response could explain the fact that several studies did not show the effect of Se supplementation on growth and weight gain of calves. Enrichment of Se in the diet did not significantly affect the slaughter weight and carcass yield of bulls. The impact and results of Se supplementation in cattle depend on physiological stage, Se status of animals, type and content of Se and types of Se administration. Further studies in Se supplementation should investigate the speciation of Se in food and yeasts, as well as understanding their metabolism and absorption. This constitute a path to exploit in order to explain certain different effects of Se. [less ▲]

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See detailMass Surveillance Technology: Trading Trojan Horses
Caponetti, Lia ULg

in Strategic Trade Review (2016), (Spring 2016), 53-71

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental ... [more ▼]

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental freedoms, and (b) surveillance technology export control, especially to third countries likely to use such technology to violate human rights. Following the Snowden Datagate scandal, many States undertook inquiries and adopted measures that, in some cases, were meant to regulate the use of mass surveillance technology. The paper will: a) assess and evaluate current regulations on mass surveillance technology and its place in democratic societies, including what is at stake in terms of technology, threats, reactions to threats, and geographic extension, b) the risks linked to the use of MST on the national level by questioning the validity of counter-terrorism measures as a justification for MST use c) analyze international trade control regimes and legislation to highlighting their inadequacy in the face of the threats posed by MST, and d) map the evolution of the EU dual-use trade control system towards a human security approach with regard to human rights protection, in order to assess the capability of the system to avoid the misuse of MST. [less ▲]

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See detailLa multimorbidité : le médecin généraliste et les systèmes de santé mis au défi
Belche, Jean ULg; Crismer, André ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 55-57

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la ... [more ▼]

Nous observons une hausse de la prévalence des maladies chroniques et, dans la majorité des situations, la présence concomitante d’au moins deux maladies chroniques, définition minimale de la multimorbidité, chez un même patient. La manière dont sont structurés la production scientifique et les systèmes de santé, dont le paradigme dominant est la prise en charge de patients avec une seule morbidité, complique la prise en charge adéquate de cette population (1). Søndergaard a dès lors exploré les difficultés que rencontre le médecin généraliste (MG) face aux patients en situation de multimorbidité au travers d’ateliers auxquels ont participé près de 180 MG et chercheurs scandinaves. [less ▲]

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See detailQuelle est l’efficacité de soins collaboratifs et intégrés pour des patients en situation de multimorbidité physique et mentale en ambulatoire ?
Belche, Jean ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016), 15(3), 58-63

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la ... [more ▼]

Alors que les études cliniques se focalisent principalement sur un problème de santé spécifique avec des patients vierges de comorbidités, il ressort d’une étude épidémiologique publiée en 2012 (1) que la multimorbidité, définie comme la présence d’au moins 2 maladies chroniques), augmente substantiellement avec l’âge (≥ 65 ans) mais qu’en nombre absolu de patients, elle touche plus de patients plus jeunes (plus de 50% en dessous de 65 ans). Près d’un tiers de ces patients multimorbides souffre de problèmes de santé mentale (dépression, troubles psychotiques, etc.), dont la gravité augmente avec le nombre de comorbidités et le statut socio-économique. L’étude analysée ici fait l’hypothèse d’un bénéfice d’un modèle de soins collaboratif et intégré en première ligne de soins sur la dépression et la gestion de la maladie chronique par le patient, tout en veillant à sélectionner une population représentative du constat démographique actuel de multimorbidité. [less ▲]

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See detailAdaptation transculturelle et validation des questionnaires VISA-P et VISA-A en français
Kaux, Jean-François ULg; Delvaux, François ULg; Oppong-Kyei, Julian et al

in Science & Sports (2016), 31(2), 65-72

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A ... [more ▼]

Objectives Patellar and calcaneal tendinopathies remain very common musculoskeletal disorders in athletes. The Victorian Institute of Sports Assessment – Patellar and – Achilles (VISA-P and VISA-A), English questionnaires developed respectively to assess the severity of patellar and calcaneal tendinopathies. The purpose of our study was to validate a French version of these questionnaires. Materials and methods The French translation and intercultural adaptation of the VISA-P and the VISA-A are made according to international recommendations. For these adaptations, 92 (VISA-P) and 116 (VISA-A) subjects were recruited and divided into 3 groups (pathological, asymptotic and sporting risk), in order to test these psychometric properties. All these subjects also had to answer to the MOS SF-36 for the validity of construct. Results The mean VISA-PF scores were 99 for the healthy people, 53 for patients with patellar tendinopathy and 86 for the athletes. The VISA-PF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.9 (Cronbach's alpha). The VISA-PF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. The mean VISA-AF scores were 99 in the healthy group, 59 in the pathological group, and 94 in the group of athletes. The VISA-AF shows excellent reliability with an inter-class correlation coefficient of 0.99. The internal consistency was 0.92 (Cronbach's alpha). The VISA-AF shows low correlations with the divergent sub-scales of the SF-36 and moderate correlations with the convergent sub-scales of the SF-36. No floor and ceiling effects were detected during the evaluation of the two questionnaires. Conclusion The French versions of the VISA-P and VISA-A questionnaires are therefore French comprehensible adaptation, reliable and adapted to French-speaking patients suffering from patellar or calcaneal tendinopathies. [less ▲]

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See detailPlatelet Rich Plasma for Treating Chronic Tendinopathy
Kaux, Jean-François ULg

in Aspetar Sports Medicine Journal (2016), 4(1), 118-122

Tendinopathy is a major problem in medicine and sports traumatology. It is due, inter alia, to mechanical overload. It remains a challenge for the medical world to the extent that its frequent resistance ... [more ▼]

Tendinopathy is a major problem in medicine and sports traumatology. It is due, inter alia, to mechanical overload. It remains a challenge for the medical world to the extent that its frequent resistance to conventional treatments never promises the patient a favourable response following therapeutic management. The development of platelet-rich plasma (PRP) is a new hope when therapeutic treatments such as NSAIDs, corticosteroid injections, eccentric rehabilitation, shock waves, etc. have shown their limits. Furthermore, since January 2011, it is no longer included on the list of doping substances (http://www.wada-ama.org/). Indeed, platelets contain various growth factors (PDGF, TGF-β, FGF, VEGF, HGF, IGF-1) which participate to the tendon healing process. PRP is obtained by centrifugation of autologous blood to obtain a platelet concentration greater than that of the blood, which varies according to the production method. PRP also contains a variable amount of lymphocytes and erythrocytes that can have a detrimental effect on wound healing. Currently, there is no formal consensus regarding the production method or the biological composition of PRP. Many laboratory studies (in vitro and/or on animal) emphasize the acceleration of the healing tendon process after injection of PRP, each growth factor exerting a specific action during healing. PRP would cause the proliferation, migration and differentiation of cells derived from circulation, improving the initial phase of the tendon healing. This anabolic process initiates the type I collagen synthesis. Although currently the effectiveness of PRP on tendon healing in vitro or in animals seems to be confirmed, clinical studies are currently still controversial. In addition, there is still only a limited number of randomized and controlled studies reviewing PRP for treating tendinopathy. However, it seems that PRP can be efficient to treat lateral epicondylitis, patellar tendinopathies and plantar fasciitis, even if the level of proofs remains low. Up to now there is not enough proofs concerning the use of PRP to treat rotator cuff or Achilles tendinopathies. More randomized, controlled and blinded studies remain needed. In conclusion, experimentally, PRP, through the local release of various growth factors stimulates tendon healing. This therapy could optimize the healing of pathological human tendons. PRP should be analysed to see whether it improves tendon healing in both humans and animals through other randomized controlled trials. [less ▲]

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See detailMicrowave-assisted extraction of pectin from unutilized pumpkin biomass
Košťálová, Zuzana; Aguedo, Mario ULg; Hromádkováa, Zdenka

in Chemical Engineering and Processing: Process Intensification (2016), 102

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid ... [more ▼]

Microwave-assisted extraction was employed to extract polysaccharides from pumpkin biomass and compared to the usual extraction by conventional heating. The effect of microwave heating time, liquid/solid (L/S) ratio and extraction temperature on the yield and molecular mass of extracted pectin from the seeded oil pumpkin biomass was investigated. Heating times ranged from 2 to 10 min, L/S ratio from 30/1 to 50/1 and temperature from 80 to 120 °C. The response surface methodology was used to optimize the effects of processing parameters to isolate pectin with medium molecular weight and with the highest yield. The retained conditions were as follows: liquid/solid ratio 50/1, microwave heating time of 10 min and a temperature of 102.2 °C. Among the studied factors, the liquid/solid ratio had the greatest influence on yield and molecular mass, respectively. Application of microwave heating in the extraction of pumpkin biomass gave a pectin with medium Mw and dramatically reduced extraction time in comparison to traditional hot acid extraction. Microwave is an excellent tool for extraction and modification of polysaccharides in one step. [less ▲]

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See detailFibulin-3 fragments are prognostic biomarkers of osteoarthritis incidence in overweight and obese women
Runhaar, Jos; Sanchez, Christelle ULg; Taralla, Sébastien et al

in Osteoarthritis Cartilage (2016), 24(4), 672-678

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg ... [more ▼]

OBJECTIVE: To determine the association between three fibulin-3 peptides and the incidence of radiographic and clinical knee osteoarthritis (OA). DESIGN: Women between 50 and 60 years, with a BMI >/=27 kg/m2, free of knee OA, were recruited. Using binary logistic regression, the association between baseline concentration of serum fibulin (Fib)3-1, Fib3-2 and Fib3-3 and incidence of clinical and radiographic knee OA after 30 months of follow-up was evaluated. RESULTS: Baseline and follow-up measurements were available for 241 women with a mean age of 55.9 +/- 3.2 years and mean BMI of 31.7 +/- 3.6 kg/m2. None of the concentrations of the three Fib3 epitopes were associated with the incidence of medial or lateral joint space narrowing (JSN) >/=1.0 mm or the incidence of Kellgren & Lawrence (K&L) grade >/=2 after 30 months. All three Fib3 epitopes were associated with the incidence of the clinical and radiographic ACR-criteria and Fib3-1 and Fib3-3 also with chronic pain at follow-up. When adjusted for the other Fib3 peptide concentrations, only Fib3-1 was significantly associated to the incidence of the American College of Rheumatology (ACR)-criteria (OR 3.2 [1.2-8.7]) and chronic pain at follow-up (OR 3.0 [1.2-7.7]). CONCLUSIONS: Baseline fibulin-3 concentrations are associated with the incidence of clinical knee OA among middle-aged overweight and obese women. Therewith, they meet the criteria of a prognostic biomarker according to the BIPED biomarker classification for OA. Further validation of the fibulin-3 epitopes seems warranted in order to better distinguish subgroups of individuals at increased risk for knee OA development. [less ▲]

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See detailLes juristes belges et la réhabilitation du droit à la guerre du Traité de Versailles au ‘Mouvement de Monaco’ de 1933-1938
Genin, Vincent ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 2016/1(Soixante et unième année), 155-188

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de ... [more ▼]

Depuis la Charte des Nations Unies de 1945, l'interdiction du "recours à la force" est consacré comme règle de droit international applicable aux Etats. Toutefois, durant l'entre-deux-guerres, surtout de 1933 à 1938, la réhabilitation d'un droit à la guerre, jugée plus pragmatique par certains juristes que sa mise "hors-la-loi" par le Pacte Briand-Kellogg de 1929, connaît quelque succès. En réaction à ce qu'ils estiment être les "failles" des Pactes de la SDN et de Paris, médecins-militaires et juristes, surtout belges et français, en vue d'"humaniser la guerre" pour, selon eux, la rendre plus rare, forment un éphémère courant, oublié et devenu anachronique : le "Mouvement de Monaco". Tel est l'objet de notre étude. [less ▲]

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See detailEvidence for the alignment of quasar radio polarizations with large quasar group axes
Pelgrims, Vincent ULg; Hutsemekers, Damien ULg

in Astronomy and Astrophysics (2016)

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on ... [more ▼]

Recently, evidence has been presented for the polarization vectors from quasars to preferentially align with the axes of the large quasar groups (LQG) to which they belong. This report was based on observations made at optical wavelengths for two large quasar groups at redshift ~1.3. The correlation suggests that the spin axes of quasars preferentially align with their surrounding large-scale structure that is assumed to be traced by the LQGs. Here, we consider a large sample of LQGs built from the Sloan Digital Sky Survey DR7 quasar catalogue in the redshift range 1.0 -􀀀 1.8. For quasars embedded in this sample, we collected radio polarization measurements with the goal to study possible correlations between quasar polarization vectors and the major axis of their host LQGs. Assuming the radio polarization vector is perpendicular to the quasar spin axis, we found that the quasar spin axis is preferentially parallel to the LQG major axis inside LQGs that have at least 20 members. This result independently supports the observations at optical wavelengths. We additionally found that when the richness of an LQG decreases, the quasar spin axis becomes preferentially perpendicular to the LQG major axis and that no correlation is detected for quasar groups with fewer than 10 members. [less ▲]

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See detailClinically Relevant Optical Properties of Bifocal, Trifocal, and Extended Depth of Focus Intraocular Lenses
Gatinel, Damien; Loicq, Jerôme ULg

in Journal of Refractive Surgery (2016), 32(4), 273-280

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ... [more ▼]

PURPOSE: To experimentally compare the optical performance of three types of hydrophobic intraocular lenses (IOLs): extended depth of focus, bifocal, and trifocal. METHODS: The tested IOLs were: TECNIS ZMB00 (bifocal; Abbott Medical Optics, Abbott Park, IL), TECNIS Symfony ZXR00 (extended depth of focus; Abbott Medical Optics), and FineVision GFree hydrophobic (trifocal; PhysIOL, Liège, Belgium). Their surface topography was analyzed by optical microscopy. Modulation transfer function (MTF) and spherical aberrations were determined on optical bench for variable pupil apertures and with two cornea models (0 μm and +0.28 μm). United States Air Force target imaging was analyzed for different focal points (near, intermediate, and far). Point spread function (PSF) and halos were quantified and compared. RESULTS: The three lenses presented step-like optic topography. For a pupil size of 3 mm or greater, clearly distinctive MTF peaks were observed for all lenses: two peaks for the extended depth of focus and bifocal lenses with +1.75 and +4.00 diopters (D) addition, respectively, and three peaks for the trifocal lens with +1.75 and +3.50 addition for intermediate and near vision, respectively. The extended depth of focus and bifocal lens had slightly higher MTF at best focus with the +0.28 μm cornea model than with the 0 μm model, whereas the trifocal lens was likely to be more independent of the corneal spherical aberrations.CONCLUSIONS: It appears that the three lenses rely on light diffraction for their optical performance, presenting halos with comparable intensities. For small pupil apertures (< 3 mm), the MTF peaks for the far and intermediate focal distances of the trifocal and extended depth of focus lenses overlap, but the trifocal lens presented an additional MTF peak for the near focal points. [less ▲]

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See detailContrasted accumulation patterns of persistent organic pollutants and mercury in sympatric tropical dolphins from the south-western Indian Ocean
Dirtu, Alin; Malavannan, Govindan; Das, Krishna ULg et al

in Environmental Research (2016), 146

Due to their high trophic position and long life span, small cetaceans are considered as suitable bioindicators to monitor the presence of contaminants in marine ecosystems. Here, we document the ... [more ▼]

Due to their high trophic position and long life span, small cetaceans are considered as suitable bioindicators to monitor the presence of contaminants in marine ecosystems. Here, we document the contamination with persistent organic pollutants (POPs) and total mercury (T-Hg) of spinner (Stenella longirostris, n=21) and Indo-Pacific bottlenose dolphins (Tursiops aduncus, n=32) sampled from the coastal waters of La Réunion (south-western Indian Ocean). In addition, seven co-occurring teleost fish species were sampled and analyzed as well. Blubber samples from living dolphins and muscle from teleosts were analyzed for polychlorinated biphenyls (PCBs), DDT and metabolites (DDTs), chlordanes (CHLs), hexachlorocyclohexanes (HCHs), hexachlorobenzene (HCB), and polybrominated diphenyl ethers (PBDEs). Methoxylated PBDEs (MeO-PBDEs), reported as having a natural origin, were also analyzed. T-Hg levels were measured in blubber and skin biopsies of the two living dolphin species. δ13C and δ15N values were determined in skin of the dolphins and in the muscle of teleosts. For PCBs, HCHs and T-Hg, concentrations were significantly higher in T. aduncus than in S. longirostris. For other POP levels, intra-species variability was high. MeO-PBDEs were the dominant compounds (55% of the total POPs) in S. longirostris, while PCBs dominated (50% contribution) in T. aduncus. Other contaminants showed similar profiles between the two species. Given the different patterns of POPs and T-Hg contamination and the stable isotope composition observed among analyzed teleosts, dietary and foraging habitat preferences possibly explain the contrasted contaminant profiles observed in the two dolphin species. Levels of each class of contaminants were significantly higher in males than females. Despite their spatial and temporal overlap in the waters of La Réunion, S. longirostris and T. aduncus are differently exposed to contaminant accumulation. [less ▲]

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See detailExercise-triggered chest pain as an isolated symptom of myocarditis in children
Tshimanga, Prisca; Daron, Benoît; FARHAT, Nesrine ULg et al

in Clinics and Practice (2016)

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See detailHistopathological effects of Aspergillus clavatus (Ascomycota: Trichocomaceae) on larvae of the southern house mosquito, Culex quinquefasciatus (Diptera: Culicidae)
Bawin, Thomas ULg; Seye, Fawrou; Boukraa, Slimane ULg et al

in Fungal Biology (2016), 120(4), 489-499

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal ... [more ▼]

Aspergillus clavatus (Ascomycota: Trichocomaceae) was previously found to be an opportunistic pathogen of mosquitoes (Diptera: Culicidae). In the present study, the mechanism leading to its insecticidal activity was investigated regarding histological damages on Culex quinquefasciatus larvae exposed to A. clavatus spores. Multiple concentration assays using spore suspensions (0.5 x 10^8 to 2.5 x 10^8 spores/ml) revealed 17.0% to 74.3% corrected mortalities after 48 h exposure. Heat-deactivated spores induced a lower mortality compared to non-heated spores suggesting that insecticidal effects are actively exerted. Spore-treated and untreated larvae were prepared for light microscopy as well as for scanning and transmission electron microscopy. Spores failed to adhere to the external body surface (except the mouth parts) of these aquatic immature stages but progressively filled the digestive tract where their metabolism seemed to activate. In parallel, the internal tissues of the larvae, i.e. the midgut wall, the skeletal muscles, and the cuticle-secreting epidermis, were progressively destroyed between 8 and 24 h of exposure. These observations suggest that toxins secreted by active germinating spores of A. clavatus in the digestive tract altered the larval tissues, leading to their necrosis and causing larval death. Fungal proliferation and sporulation then occurred during a saprophytic phase. A. clavatus enzymes or toxins responsible for these pathogenic effects need to be identified in further studies before any use of this fungus in mosquito control. [less ▲]

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See detailInsertion professionnelle et parcours enseignants : mise en perspective
Simons, Germain ULg

in Didactiques en pratique (2016), (2),

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See detailRELMs in the Realm of Helminths
Horsnell, William G. C.; Dewals, Benjamin G ULg

in Trends in parasitology (2016)

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus ... [more ▼]

Resistin-like molecule (RELM) proteins are essential for immunity to helminths. Recently, Chen and collaborators identified a dominant role for RELMalpha over RELMbeta in host immunity to Nippostrongylus brasiliensis using a double knockout system. The study highlighted how important and yet divergent the contributions of these proteins are in the control of helminth infections. [less ▲]

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See detailLe travailleur à temps partiel et la présomption de travail à temps plein
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (14), 654-655

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la ... [more ▼]

L'article oppose la présomption de travail à temps plein énoncée par l’article 171 de la loi-programme du 22 décembre 1989, qui est étrangère aux relations entre l’employeur et le travailleur, à la sanction inscrite dans l'article 11bis de la loi relative aux contrats de travail. Le travailleur ne peut alléguer la présomption pour obtenir le paiement d’arriérés de salaire ou d’une indemnité compensatoire de préavis calculés sur la base d’une rémunération à temps plein. [less ▲]

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See detailLagrangian and arbitrary Lagrangian Eulerian simulations of complex roll-forming processes
Crutzen, Yanick ULg; Boman, Romain ULg; Papeleux, Luc ULg et al

in Comptes Rendus Mécanique (2016), 344(4-5), 251-266

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ... [more ▼]

The Arbitrary Lagrangian Eulerian (ALE) formalism is a breakthrough technique in the numerical simulation of the continuous-type roll-forming process. In contrast to the classical Lagrangian approach, the ALE formalism can compute the hopefully stationary state for the entire mill length with definitely effortless set-up tasks thanks to a nearly-stationary mesh. In this paper, advantages of ALE and Lagrangian formalisms are extensively discussed for simulating such continuous-type processes. Through a highly complex industrial application, the ease of use of ALE modelling is illustrated with the in-house code METAFOR. ALE and Lagrangian results are in good agreement with each other. [less ▲]

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See detailLes kystes ovariens chez le cobaye
Gillet, Aline; Deflers, Hélène ULg; Marlier, Didier ULg

in Revue de Médecine Vétérinaire (2016), 167(3-4), 51-58

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See detailDiurnal cycle and multi-decadal trend of formaldehyde in the remote atmosphere near 46° N
Franco, Bruno ULg; Marais, Eloise A.; Bovy, Benoît ULg et al

in Atmospheric Chemistry and Physics (2016), 16

Only very few long-term records of formaldehyde (HCHO) exist that are suitable for trend analysis. Furthermore, many uncertainties remain as to its diurnal cycle, representing a large short-term ... [more ▼]

Only very few long-term records of formaldehyde (HCHO) exist that are suitable for trend analysis. Furthermore, many uncertainties remain as to its diurnal cycle, representing a large short-term variability superimposed on seasonal and inter-annual variations that should be accounted for when comparing ground-based observations to e.g., model results. In this study, we derive a multi-decadal time series (January 1988 – June 2015) of HCHO total columns from ground-based high-resolution Fourier transform infrared (FTIR) solar spectra recorded at the high-altitude station of Jungfraujoch (Swiss Alps, 46.5° N, 8.0° E, 3580 m a.s.l.), allowing for the characterization of the mid-latitudinal atmosphere for background conditions. First we investigate the HCHO diurnal variation, peaking around noontime and mainly driven by the intra-day insolation modulation and methane (CH4) oxidation. We also characterize quantitatively the diurnal cycles by adjusting a parametric model to the observations, which links the daytime to the HCHO columns according to the monthly intra-day regimes. It is then employed to scale all the individual FTIR measurements on a given daytime in order to remove the effect of the intra-day modulation for improving the trend determination and the comparison with HCHO columns simulated by the state-of-the-art chemical transport model GEOS-Chem v9-02. Such a parametric model will be useful to scale the Jungfraujoch HCHO columns on satellite overpass times in the framework of future calibration/validation efforts of space borne sensors. GEOS-Chem sensitivity tests suggest then that the seasonal and inter-annual HCHO column variations above Jungfraujoch are predominantly led by the atmospheric CH4 oxidation, with a maximum contribution of 25 % from the anthropogenic non-methane volatile organic compound precursors during wintertime. Finally, trend analysis of the so-scaled 27-year FTIR time series reveals a long-term evolution of the HCHO columns in the remote troposphere to be related with the atmospheric CH4 fluctuations and the short-term OH variability: +2.9 %/yr between 1988 and 1995, -3.7 %/yr over 1996-2002 and +0.8/% yr from 2003 onwards. [less ▲]

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See detailAbout Quaternary prevention in Public health ; comment on Dr Jong-Myon Bae paper
Jamoulle, Marc ULg

in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016), 49(2), 139-140

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it ... [more ▼]

The recent paper of Dr Jong-Myon Bae about Quaternary Prevention and Public Health in your journal has attracted my interest. The spread of this concept is beyond all expectation and I am quite happy it contributes to the analytic thinking of complexity of health care. The particular application of the quaternary prevention (P4) concept is absolutely brilliant. Nevertheless I would propose some slight modifications to the table 1 edited by the author which I have taken the liberty to reproduce here with the due authorization of Dr Bae and after several mail exchanges with him. [less ▲]

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See detailCharacterization of monovarietal virgin olive oils from introduced cultivars in eastern Morocco
Mansouri, Farid ULg; Benmoumen, A.; Richard, Gaetan ULg et al

in Rivista Italiana Sostanze Grasse (2016), 93

The aim of this study was to characterize monovarietal virgin olive oils (VOOs) of new high-density planting system of three European cultivars (Arbequina, Arbosana and Koroneiki), recently introduced in ... [more ▼]

The aim of this study was to characterize monovarietal virgin olive oils (VOOs) of new high-density planting system of three European cultivars (Arbequina, Arbosana and Koroneiki), recently introduced in eastern Morocco. VOOs’ characterization has been carried out by analyzing several parameters, such as quality indexes, fatty acid contents, minor components, and olive oils’ oxidative stability index (OSI). In this study, we have also conducted a comparison between these monovarietal VOOs and olive oils of autochthones cultivar Picholine marocaine. Significant differences between the analyzed VOOs were highlighted. Koroneiki’s VOO had a high phenols content (493.66 mg/kg) and, consequently, the best oxidative stability (94.83 h); Arbrosana’s VOO was distinguished by its abundance of α-tocopherol (460.07 mg/kg) and by an intermediate OSI (64.83 h). In addition, results showed, firstly, that in all the analyzed oils decarboxymethyl ligstroside aglycone and decarboxymethyl oleuropein aglycone were the main phenolic compounds, and, secondly, that VOOs of Koroneiki and Arbosana seem to have similar profiles, with a high content of natural antioxidants and a high oleic/linoleic ratio, thus boasting a better shelf life. [less ▲]

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See detailA new method using insert-based systems (IBS) to improve cell behavior study on flexible and rigid biomaterials.
Grenade, Charlotte; Moniotte, Nicolas; Rompen, Eric ULg et al

in Cytotechnology (2016)

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of ... [more ▼]

In vitro studies about biomaterials biological properties are essential screening tests. Yet cell cultures encounter difficulties related to cell retention on material surface or to the observation of both faces of permeable materials. The objective of the present study was to develop a reliable in vitro method to study cell behavior on rigid and flexible/permeable biomaterials elaborating two specific insert-based systems (IBS-R and IBS-F respectively). IBS-R was designed as a specific cylindrical polytetrafluoroethylene (PTFE) system to evaluate attachment, proliferation and morphology of human gingival fibroblasts (HGFs) on grade V titanium and lithium disilicate glass-ceramic discs characteristics of dental prostheses. The number of cells, their covering on discs and their morphology were determined from MTS assays and microscopic fluorescent images after 24, 48 and 72 h. IBS-F was developed as a two components system to study HGFs behavior on guided bone regeneration polyester membranes. The viability and the membrane barrier effect were evaluated by metabolic MTS assays and by scanning electron microscopy. IBS-R and IBS-F were shown to promote (1) easy and rapid handling; (2) cell retention on biomaterial surface; (3) accurate evaluation of the cellular proliferation, spreading and viability; (4) use of non-toxic material. Moreover IBS-F allowed the study of the cell migration through degradable membranes, with an access to both faces of the biomaterial and to the bottom of culture wells for medium changing. [less ▲]

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See detailDurée excessive d'une procédure pénale et mise en cause de la responsabilité civile de l'Etat
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (2016/12), 569-574

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire ... [more ▼]

Le jugement commenté présente la principale particularité d'aborder la mise en cause de la responsabilité civile de l'Etat en cas de dépassement du délai raisonnable d'une procédure pénale. Le commentaire de cette décision s'attache encore à mettre en perspective cette décision avec l'arrêt Panju c. Belgique prononcé le 28 octobre 2014 par la Cour européenne des droits de l'homme. [less ▲]

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See detailStratospheric aerosol - Observations, processes, and impact on climate
Kremser, Stefanie; Thomason, Larry W.; von Hobe, Marc et al

in Reviews of Geophysics (Washington, D.C. : 1985) (2016)

Interest in stratospheric aerosol and its role in climate has increased over the last decade due to the observed increase in stratospheric aerosol since 2000 and the potential for changes in the sulfur ... [more ▼]

Interest in stratospheric aerosol and its role in climate has increased over the last decade due to the observed increase in stratospheric aerosol since 2000 and the potential for changes in the sulfur cycle induced by climate change. This review provides an overview about the advances in stratospheric aerosol research since the last comprehensive assessment of stratospheric aerosol was published in 2006. A crucial development since 2006 is the substantial improvement in the agreement between in situ and space-based inferences of stratospheric aerosol properties during volcanically quiescent periods. Furthermore, new measurement systems and techniques, both in situ and space-based, have been developed for measuring physical aerosol properties with greater accuracy and for characterizing aerosol composition. However, these changes induce challenges to constructing a long-term stratospheric aerosol climatology. Currently, changes in stratospheric aerosol levels less than 20% cannot be confidently quantified. The volcanic signals tend to mask any non-volcanically driven change, making them difficult to understand. While the role of carbonyl sulfide (OCS) as a substantial and relatively constant source of stratospheric sulfur has been confirmed by new observations and model simulations, large uncertainties remain with respect to the contribution from anthropogenic sulfur dioxide (SO2) emissions. New evidence has been provided that stratospheric aerosol can also contain small amounts of non-sulfate matter such as black carbon and organics. Chemistry-climate models have substantially increased in quantity and sophistication. In many models the implementation of stratospheric aerosol processes is coupled to radiation and/or stratospheric chemistry modules to account for relevant feedback processes. [less ▲]

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