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See detailBeyond survival and uncertainty. The livelihood practices of former Gécamines workers (D.R.Congo)
Rubbers, Benjamin ULg

in Review of African Political Economy (in press)

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See detailGardez votre carte d'identité en poche
Bouhon, Frédéric ULg

in Revue de la Faculté de Droit de l'Université de Liège (in press), 2017/1

Dans cette brève contribution, nous abordons la question de l'utilisation de la carte d'identité en Begique et les problèmes que cela soulève en matière de gestion des données à caractère personnel. À ... [more ▼]

Dans cette brève contribution, nous abordons la question de l'utilisation de la carte d'identité en Begique et les problèmes que cela soulève en matière de gestion des données à caractère personnel. À cette fin, nous revenons d’abord sur l’obligation de porter une carte d’identité et sur les raisons d’être de ce document. Nous essayons ensuite de mesurer l’ampleur des risques qu’implique le traitement des données liées à la carte, avant de nous focaliser sur certains usages particuliers de cette dernière. [less ▲]

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See detailUne vision moderne de la dépression et de son hétérogénéité
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Revue Francophone de Clinique Comportementale et Cognitive (in press)

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See detailLe cercle de lecture, un dispositif pour construire ensemble des compétences de lecteurs et d'enseignants
Scheepers, Caroline ULg; Outers, Pierre ULg; Werner, Anne-Catherine ULg et al

in Didactiques en Pratique (in press)

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé ... [more ▼]

Comment accompagner les premiers pas des stagiaires débutants ? À cette vaste et complexe question, le présent article envisage d’apporter un très modeste éclairage. Ainsi, sera décrit, conceptualisé, analysé et discuté un projet collaboratif qui a associé étroitement théorie et pratique, université et école secondaire, expérimentation et transposition d’un dispositif, didactique disciplinaire et didactique générale. Plus concrètement, il s’est agi de faire expérimenter en tant qu’apprenants un cercle de lecture et un atelier d’écriture par les étudiants romanistes qui suivent le cours de première année de master centré sur la didactique du français langue première, avant de les inviter à transposer l’outil ainsi testé dans leur classe de stage. Seront prises en compte différentes traces : nos consignes, les journaux de stage, les portfolios, les consignes des étudiants, les traces recueillies auprès des élèves du secondaire, les rapports des maitres de stage, etc. Nous verrons in fine que le processus mis en place confirme, toutes proportions gardées, la validité et la pertinence du principe d’homologie entre les activités testées par les stagiaires lors de leur formation initiale à l’université et celles que les formateurs leur recommandent de mettre en œuvre dans leurs classes. [less ▲]

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See detailDe la quantité de demandeurs d’emploi à la qualité de l’accompagnement. Des professionnels entre « esprit gestionnaire » et relation de service
Remy, Céline ULg; Lavitry, Lynda

in Revue Française de Socio-Economie (in press)

L’article explore les liens et les zones de tension entre les politiques de mesure de la performance et la qualité de l’accompagnement à l’emploi telle qu’elle est définie dans les pratiques et discours ... [more ▼]

L’article explore les liens et les zones de tension entre les politiques de mesure de la performance et la qualité de l’accompagnement à l’emploi telle qu’elle est définie dans les pratiques et discours des agents et prestataires des services publics de l’emploi en France et en Belgique francophone. L’objectif est de démontrer que le pilotage du travail des intermédiaires de l’emploi par les indicateurs de mesure donne lieu à des pratiques, parfois clandestines, de mise en conformité avec le rendement statistique de leur activité. Mais parallèlement, les excès d’une quantification perçue comme abusive ou dangereuse pour leur ethos professionnel poussent une partie d’entre eux à agir en contradiction avec ces principes gestionnaires et ce, au nom de l’intérêt du demandeur d’emploi et de la prise en compte de la qualité des emplois, tendances que l’on décèle dans les deux pays étudiés. [less ▲]

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See detailNote a Jacopino del Conte e approfondimenti sulla sua attività giovanile
Geremicca, Antonio ULg

in Proporzioni. Annali della Fondazione Roberto Longhi (in press)

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See detailOrganisational aspects of paediatric parenteral nutrition
Puntis, J; Hojsak, I; Ksiazyk, J et al

in Clinical Nutrition (in press)

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See detailLa collaboration entre architectes et plasticiens à Liège dans les années 1930.
Charlier, Sébastien ULg

in In Situ, revue des patrimoines (in press), 26

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales ... [more ▼]

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales, le mensuel revendique une vision transversale de l’architecture où la réflexion plastique occupe une place centrale. Dès le départ, elle s’associe à Anthologie, revue imprégnée des théories futuristes et qui diffuse les artistes de l’avant-garde locale. D’abord par le biais de l’édition et des expositions, plasticiens et architectes travaillent ensuite ensemble dans le cadre de projets ambitieux financés par les pouvoirs publics. Cette contribution revient aux racines de cette collaboration en définissant les liens théoriques ou personnels unissant les deux revues. En se concentrant sur les infrastructures publiques, elle comment les artistes et les architectes ont répondu ensemble aux exigences concrètes de la commande en les replaçant dans le contexte social, politique et économique d’une ville belge de seconde importance à la veille de la Seconde Guerre mondiale. [less ▲]

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See detailComprehensive Human Papilloma Virus (HPV) Genotyping in Cervical Squamous Cell Carcinomas and its Relevance to Cervical Cancer Prevention in Malawian Women
Howitt, Brooke; Herfs, Michael ULg; Tomoka, Tamiwe et al

in Journal of Global Oncology (in press)

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See detailArrêts sur images – usages et pratiques du photogramme
Thonon, Jonathan ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un ... [more ▼]

Le photogramme est, au cinéma, la plus petite unité de prise de vue. Image fixe, unité élémentaire du film, le photogramme forme la cellule figée d’un mouvement qui se reconstitue sous l’effet d’un défilement réglé (24 photogrammes/seconde) par le dispositif technique du cinéma. Image paradoxale en ce qu’elle reste invisible au spectateur malgré sa force iconique, le photogramme trouve cependant, dans le flux qui le conduit insensiblement à la disparition, certaines zones de visibilité qui en révèlent le caractère à la fois fragile et intensif. Nous allons donc envisager certaines pratiques ou certains usages du photogramme cinématographique, tout en essayant de dégager, au départ de ces pratiques, les éléments d’une théorie du photogramme, que Roland Barthes et Sylvie Pierre appelaient déjà de leurs vœux. Des protos-photogrammes et de leur usage scientifique chez Muybridge et Marey, aux usages artistiques contemporains, en passant par des pratiques publicitaires, promotionnelles ou analytiques, nous allons voir que le photogramme reste un objet singulier. [less ▲]

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See detailTraduction de "Sense and Its Place in Meaning" de W.V.O. Quine
Moreau, Timothée ULg

in Philosophie (in press)

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See detailIngéniérie entre recherche et formation
Job, Pierre; Schneider-Gilot, Marguerite ULg

in Education et Didactique (in press)

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See detailExploring Metacognition as Support for Learning Transfer
Scharff, Lauren; Draeger, John; Verpoorten, Dominique ULg et al

in Teaching & Learning Inquiry: The ISSoTL Journal (in press)

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning ... [more ▼]

The ability to transfer learning to new situations lies at the heart of lifelong learning and the employability of university graduates. Because students are often unaware of the importance of learning transfer and staff do not always explicitly articulate this expectation, this article explores the idea that metacognition (intentional awareness and the use of that awareness) might enhance the development of learning transfer. Our exploratory study includes results from a survey of 74 staff and 118 students from five institutions in Australia, Belgium, UK, and USA. Our data indicate that many staff and a majority of students do not have a clear understanding of what learning transfer entails, and that there are many mismatches between staff and student perceptions, attitudes, and behaviors regarding learning transfer. This helps explain why learning transfer does not occur as often as it could. We found significant positive correlations between thinking about transfer and thinking about learning processes and the likelihood to use awareness of metacognition to guide practice. Our findings suggest a positive relationship between metacognition and learning transfer. Implications for scholarship of teaching and learning are discussed. [less ▲]

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See detailA Piano Made in Australia: Reinventing an Emblem of Cultural Wealth in Murray Bail's The Voyage
Herbillon, Marie ULg

in Antipodes: A Global Journal of Australian/New Zealand Literature (in press), 31(2),

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See detailBrentano’s epistemology of history: inner experience and the reality of the past
Boccaccini, Federico ULg

in Perspectives on Science (2018)

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See detailFrom Ontology to Psychoanalysis. Benussi and Musatti on the Concept of Mental Reality
Boccaccini, Federico ULg

in Meinong Studies / Meinong Studien (2018), 9

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See detailAlbertina, más viva que muerta
Dubois, Jacques ULg; Mogollon Zapata, Juan Manuel ULg

in Revista Linguística y Literatura (2017), 72(2),

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See detailImpact of spatio-temporal shade dynamics on wheat growth and yield, perspectives for temperate agroforestry
Artru, Sidonie ULg; Garré, Sarah ULg; Dupraz, Christian et al

in European Journal of Agronomy (2017)

A stumbling block to the adoption of silvoarable agroforestry systems is the lack of quantitative knowledge on the performance of different crops when competing for resources with trees. In North-Western ... [more ▼]

A stumbling block to the adoption of silvoarable agroforestry systems is the lack of quantitative knowledge on the performance of different crops when competing for resources with trees. In North-Western Europe, light is likely to be the principal limiting resource for understorey crops, and most agronomic studies show a systematic reduction of final yield as shade increases. However the intensity of the crop response depends on both the environmental conditions and the shade characteristics. This study addressed the issue by monitoring winter wheat (Triticum aestivum L.) growth, productivity and quality under artificial shade provided by military camouflage shade-netting, and using the Hi-sAFe model to relate the artificial shade conditions to those applying in agroforestry systems. The field experiment was carried out over two consecutive years (2013–14 and 2014–15) on the experimental farm of Gembloux Agro-Bio Tech, Belgium. The shade structures recreated two shade conditions: periodic shade (PS) and continuous shade (CS), with the former using overlapping military camouflage netting to provide discontinuous light through the day, and the latter using conventional shade cloth. The experiment simulated shading from a canopy of late-flushing hybrid walnut leaves above winter wheat. Shading was imposed 16 (2013–14) and 10 (2014–15) days before flowering and retained until harvest. The crop experienced full light conditions until the maximum leaf area index stage (LAImax) had been reached. In both years, LAI followed the same dynamics between the different treatments, but in 2013–2014 an attack of the take-all disease (Gaeumannomyces graminis var. tritici) reduced yields overall and prevented significant treatment effects. In season 2014–15 the decrease in global radiation reaching the crop during a period of 66 days (CS: – 61% and PS: – 43%) significantly affected final yield (CS: – 45% and PS: – 25%), mainly through a reduction of the average grain weight and the number of grain per m2. Grain protein content increased by up to 45% under the CS treatment in 2015. Nevertheless, at the plot scale, protein yield (t/ha) did not compensate for the final grain yield decrease. The Hi-sAFe model was used to simulate an agroforestry plot with two lines of walnut trees running either north-south or east-west. The levels of artificial shade levels applied in this experiment were compared to those predicted beneath trees growing with similar climatic conditions in Belgium. The levels used in the CS treatment are only likely to occur real agroforestry conditions on 10% of the cropped area until the trees are 30 years old and only with east-west tree row orientation. [less ▲]

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See detailA Receding Horizon Approach to Incorporate Frequency Support into the AC/DC Converters of a Multi-Terminal DC Grid
Papangelis, Lampros ULg; Panciatici, Patrick; Debry, Marie-Sophie et al

in Electric Power Systems Research (2017)

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter ... [more ▼]

This paper proposes a novel control scheme for provision of frequency support among asynchronous AC areas through HVDC grids. It is based on local controllers, each acting on a voltage source converter, using local measurements only, and supporting frequency of the adjacent AC area after a significant disturbance. The new discrete control is combined with the existing DC voltage droop technique. The formulation, inspired of Receding Horizon Control, enables providing to the AC area the desired frequency support, while at the same time taking into account various constraints, such as maintaining the DC voltage between secure operating limits. Examples obtained from a test system with a five-terminal DC network connecting two asynchronous areas demonstrate the effectiveness and robustness of the proposed control scheme in various scenarios, with emphasis on component failures. [less ▲]

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See detailElectro dynamic fragmentation of printed wiring boards as a preparation tool for their recycling
Martino, Rémi; Iseli, Cedric; Gaydardzhiev, Stoyan ULg et al

in Minerals Engineering (2017), 107

The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed ... [more ▼]

The use of Electro Dynamic Fragmentation (EDF) enables selective fragmentation of materials through generating electrical discharges as a means of fracturing. Liberated materials can be thus processed downstream in a more efficient way especially when value-added End-of-Life (EoL) electronic equipment is recycled. The aim of this study was to assess the benefits of the EDF technology towards processing of EoL printed wiring boards (PWBs) in view their recyclability. Printed wiring boards were comminuted using EDF at three different settings and with a hammer mill for comparative experiment. The products coming out were characterized by optical microscopy, SEM and liberation oriented leaching. Subsamples from the various EDF stages were inspected to investigate the progress of cracks and degree of copper layers exposure. The different energy levels used during the EDF processing have resulted in different degrees of PWBs damages, starting from components removal to entire structure perturbation and size reduction. EDF has resulted in generation of a lesser amount of fines, however the optimal approach in view energy efficient post-processing of the studied PWBs was the combination between single-stage EDF for components removal only with subsequent shredding of the depopulated boards. [less ▲]

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See detailDes Héritages devenus concepts. Remarques sur la notion d’ipséité chez Sartre
Recchia, Fabio ULg

in Revista Ética e Filosofia Política (2017), 1

Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa ... [more ▼]

Il n’est en philosophie d’héritage que gagné. Et en m’installant dans cette ambigüité propre au savoir philosophique, j’examine, dans ce texte, un développement peu étudié de la pensée sartrienne : sa théorie du « circuit de l’ipséité » de la conscience. Quant à mon objectif, il s’agira de faire le point sur le processus de maturation intellectuelle à l’issue duquel Sartre conçut l’ipséité comme un circuit. Ainsi je mets en évidence que certaines des réflexions de Heidegger, Bergson et Mauss, sur la notion d’identité personnelle ont constitué les héritages philosophiques mobilisés et transformés par la théorie sartrienne de l’ipséité. [less ▲]

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See detailA decision support tool for transient stability preventive control
Pertl, Michael; Weckesser, Johannes ULg; Rezkalla, Michel et al

in Electric Power Systems Research (2017), 147

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the ... [more ▼]

The paper presents a decision support tool for transient stability preventive control contributing to increased situation awareness of control room operators by providing additional information about the state of the power system in terms of transient stability. A time-domain approach is used to assess the transient stability for potentially critical faults. Potential critical fault locations are identified by a critical bus screening through analysis of pre-disturbance steady-state conditions. The identified buses are subject to a fast critical contingency screening determining the actual critical contingencies/buses. These two screenings aim at reducing the computational burden of the assessment, since only contingencies considered as critical are taken into account. The critical clearing times for the critical contingencies are determined. A preventive re-dispatch of generators to ensure a predefined minimum critical clearing time for faults at all buses is proposed, while costs are minimized. The results of the assessment are presented to the control room operator, who decides to accept the suggested dispatch or to repeat the assessment considering additional user-specific constraints. The effectiveness of the proposed method is demonstrated on a standard nine-bus and the New England test system. [less ▲]

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See detailMagnetic Shielding Above 1 T at 20 K With Bulk, Large Grain YBCO Tubes Made by Buffer-aided Top Seeded Melt Growth
Wera, Laurent ULg; Fagnard, Jean-François ULg; Kumar, Numbury Devendra et al

in IEEE Transactions on Applied Superconductivity (2017), 27(4),

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and ... [more ▼]

YBCO tubes of ~ 10 mm diameter closed at one extremity were engineered by a Buffer-Aided Top Seeded Melt Growth fabrication process (BA-TSMG). These tubes can act as efficient “dc” magnetic shields and are observed to reduce axial flux densities of 1.5 T by a factor of 100 at 20 K. Such performances are comparable in magnitude to the record threshold inductions reported for bulk MgB2 and Bi-2212 materials at lower temperatures. Magnetic shielding measurements for open and closed tubes at 77 K also show that the presence of the cap improves substantially the shielding performance at the closed extremity since it reduces the penetration through the open end. This fabrication technique is extremely promising for shielding “dc” stray fields generated by HTS magnets operated in a temperature range obtained by cryocoolers, liquid hydrogen (20 K) or liquid neon (27 K). [less ▲]

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See detailNumerical modelling of micro-plasto-hydrodynamic lubrication in plane strip drawing
Carretta, Yves ULg; Bech, Jakob; Legrand, Nicolas et al

in Tribology International (2017), 110

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming ... [more ▼]

This paper presents a new finite element model capable of predicting the onset of micro-plasto-hydrodynamic (MPH) lubrication and the amount of lubricant escaping from surface pockets in metal forming. The present approach is divided in two steps. First, a simulation at the macroscopic level is conducted. Then, a second simulation highlighting microscopic liquid lubrication mechanisms is achieved using boundary conditions provided by the first model. These fluid-structure interaction computations are made possible through the use of the Arbitrary Lagrangian Eulerian (ALE) formalism. The developed methodology is validated by comparison to experimental measurements conducted in plane strip drawing. The effect of physical parameters like the drawing speed, the die angle and the strip thickness reduction is investigated. The numerical results show good agreement with experiments. [less ▲]

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See detailInsect fatty acids: A comparison of lipids from three Orthopterans and Tenebrio molitor L. larvae
Paul, Aman ULg; Frederich, Michel ULg; Caparros Megido, Rudy ULg et al

in Journal of Asia-Pacific Entomology (2017), 20(2), 337-340

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and ... [more ▼]

In order to explore some potential insect sources of food lipids, the lipid compositions of three Orthopterans (Acheta domesticus, Conocephalus discolor and Chorthippus parallelus) were analyzed and compared with those of Tenebrio molitor larvae. A. domesticus, Co. discolor, Ch. parallelus and T. molitor larvae were found to contain approximately 15%, 13%, 10% and 32% lipids on dry weight, respectively. The lipids from three Orthopterans contain much higher amounts of essential fatty acids than those of T. molitor larvae. The two Orthopterans of the suborder Ensifera i.e., A. domesticus and Co. discolor contain linoleic acid in major quantities, while Ch. parallelus of the suborder Caelifera, contain α-linolenic acid in major quantities. The consumption of linoleic and α-linolenic fatty acid is linked with numerous health promoting effects. The factors that contribute to differences in fatty acid profiles of these insects are being discussed. At last the nutritional parameters including polyunsaturated to saturated and omega 6 to omega 3 fatty acid ratios of these insect lipids are also being discussed to understand the potential role of these lipids in human nutrition. [less ▲]

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See detailA computational stochastic multiscale methodology for MEMS structures involving adhesive contact
Hoang Truong, Vinh ULg; Wu, Ling ULg; Paquay, Stéphane et al

in Tribology International (2017), 110

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS ... [more ▼]

This work aims at developing a computational stochastic multiscale methodology to quantify the uncertainties of the adhesive contact problems due to capillary effects and van der Waals forces in MEMS. Because the magnitudes of the adhesive forces strongly depend on the surface interaction distances, which in turn evolve with the roughness of the contacting surfaces, the involved structural behaviors suffer from a scatter. To numerically predict the probabilistic behaviors of structures involving adhesion, the proposed method introduces stochastic meso-scale random apparent contact forces which can be integrated into a stochastic finite element model. Because the evaluation of their realizations is expensive, a generator for the random apparent contact force using the polynomial chaos expansion is constructed in an efficient way. [less ▲]

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See detailPeriod–luminosity relations of fast-rotating B-type stars in the young open cluster NGC 3766
Saio, H.; Ekström, S.; Mowlavi, N. et al

in Monthly Notices of the Royal Astronomical Society (2017), 467(4), 3864-3873

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We ... [more ▼]

We study the pulsational properties of rapidly rotating main-sequence B-type stars using linear non-adiabatic analysis of non-radial low-frequency modes taking into account the effect of rotation. We compare the properties of prograde sectoral g and retrograde r modes excited by the κ mechanism at the Fe opacity peak with the newly discovered period–luminosity relation that is obeyed by a group of fast-rotating B-type stars in the young open cluster NGC 3766. The observed relation consists of two sequences in the period versus magnitude diagram, at periods shorter than 0.5 d. We find that this property is consistent with similar period–luminosity relations predicted for excited sectoral prograde g modes of azimuthal orders m = −1 and −2 in fast-rotating stars along an isochrone. We further show that some of the rapidly rotating stars that have photometric variability with periods longer than a day may be caused by r-mode pulsation predicted to be excited in these stars. One fast-rotating star, in particular, shows both short and long periods that can be explained by the simultaneous excitation of g- and r-mode pulsations in models of fast-rotating stars. [less ▲]

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See detailIdentification of non-stationary dynamical systems using multivariate ARMA models
Bertha, Mathieu ULg; Golinval, Jean-Claude ULg

in Mechanical Systems and Signal Processing (2017), 88

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]

This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]

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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULg; Evrard, Brigitte ULg

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailFrom distant neighbours to bedmates: Exploring the synergies between the social economy and sustainable development
Hudon, Marek; Huybrechts, Benjamin ULg

in Annals of Public and Cooperative Economics (2017), 88(2),

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two ... [more ▼]

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two research fields and the increasing combination of these fields in the literature. Several avenues through which social enterprises can contribute to the transition towards sustainable development are then identified. This is followed by a discussion of how and why the combination can be particularly fruitful both for the social economy and for sustainability transition movements. We also highlight some important challenges facing the social economy with regard to its contribution to sustainable development. Finally we introduce the papers that constitute this special issue and show how they contribute, individually and collectively, to a better understanding of the increasing linkage between the social economy and sustainable development. [less ▲]

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See detailMerci à vous!
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2017), 60(3),

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See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

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See detailCo-creating service recovery after service failure: The role of brand equity
Hazee, Simon ULg; Van Vaerenbergh, Yves; Armirotto, Vincent

in Journal of Business Research (2017), 74

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See detailThe internet as a source of information used by women after childbirth to meet their need for information: A web-based survey.
Slomian, Justine ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

in Midwifery (2017), 48

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to ... [more ▼]

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to meet their need of information; (c) to describe how the respondents evaluate the reliability of the information found; (d) to understand how the information found on the Internet affects women's decision-making; and (e) to appreciate how health professionals react to the information found by the women. DESIGN: this study used a large web-based survey that was widely broadcasted on various websites and social networks. SETTING AND PARTICIPANTS: belgian women who had a child under 2 years old and who agreed to participate were included in the study. FINDINGS: 349 questionnaires were valid for analyses. After childbirth, 90.5% of women admitted to using the Internet to seek information about themselves or about their baby, regardless of socioeconomic status or age. There were various reasons for seeking information on the Internet, but the most frequent reason the women expressed was to find information 'on their own' (88.1%). The most searched for topic was breastfeeding. The women believed that the information was quite useful (82.7%) but they assigned an average score of 5.3 out of 10 for the quality of the information they found on the Internet. Approximately 80% of the women felt that the Internet helped them control a decision that they made 'a little', 'often' or 'very often'. Professionals are not always willing to talk about information found on the Internet with mothers. Therefore, many women believed that health professionals should suggest reliable Internet websites for new mothers. CONCLUSIONS: the integration of the Internet and new technologies could be a useful tool during postpartum management. [less ▲]

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULg; Béchet, Eric ULg; Kerschen, Gaëtan ULg

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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See detailModeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropy
van den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric ULg et al

in Computers and Geotechnics (2017), 85

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See detailDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
Degueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et al

in Toxicon (2017), 130

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]

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See detailIsotopic half-life and enrichment factor in two species of European freshwater fish larvae: an experimental approach
Latli, Adrien; Sturaro, Nicolas ULg; Dujardin, Nelson et al

in Rapid Communications in Mass Spectrometry (2017), 31(8), 685-692

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue ... [more ▼]

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in two freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation. After yolk sac resorption, larvae were fed for 5 weeks with prey similar to their natural diet (Artemia nauplii) up to the isotopic equilibrium followed by Chironomid larvae. Stable isotope measurements were carried out using a continuous flow isotope ratio mass spectrometer coupled to an elemental analyser. RESULTS: Changes in isotopic composition strongly followed the predictions of exponential growth and time-dependent models. The isotopic HL varied between 8.2 and 12.6 days and the TEF of nitrogen and carbon ranged from 1.7 to 2.1‰ and from –0.9 to 1.2 ‰, respectively. The incorporation of dietary 13C was due more to the production of new tissue (between 56 and 79%) than to the metabolic process. Chub allocated more energy to growth than roach and the Chironomidae diet contributed more to the consumers’ growth than the Artemia diet. CONCLUSIONS: Metabolic rates seemed lower for chub than for roach, especially when they were fed with Chironomidae. A Chironomidae-based diet would be more profitable to chub, and the high associated growth rate could increase the development of the fish larvae. The HL and TEF were in the range of those reported in the literature. These results will be helpful for field-based studies, because they can help to increase the accuracy of models. [less ▲]

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See detailPhotosensitive polydimethylsiloxane networks for adjustable-patterned films
Jellali, Rachid; Alexandre, Michaël; Jérôme, Christine ULg

in Polymer Chemistry (2017), 8(16), 2499-2508

Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV ... [more ▼]

Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV light having a wavelength of above 300 nm, multifunctional coumarin-PDMSs are transformed into covalent networks via [2 + 2] photocycloaddition of two coumarin moieties forming a cyclobutane ring. Taking advantage of the possible localized irradiation through a photomask, a novel concept to generate patterned PDMS films with various surface topologies was demonstrated. This concept is based on the combination of a low molar mass difunctional PDMS with a multifunctional PDMS of a high molar mass forming a photoreversible network allowing osmotic diffusion of a linear PDMS-coumarin of low mole- cular weight in a loosely crosslinked network. Advantageously, illumination by a light source at 254 nm induces the photocleavage of the cyclobutane cross-links offering some photo-induced reversibility to the PDMS network. These novel photo-responsive networks are interesting for several applications, in photo-adaptable biomedical implants (particularly photo-adjustable intra-ocular lenses), photo-tuneable patterned microsystems (e.g. for microfluidics) and photo-switchable controlled release systems. [less ▲]

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See detailReconstructions of the 1900–2015 Greenland ice sheet surface mass balance using the regional climate MAR model
Fettweis, Xavier ULg; Box, Jason; Agosta, Cécile ULg et al

in Cryosphere (The) (2017), 11

With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional ... [more ▼]

With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional; version 3.5.2) model with the ERA-Interim (ECMWF Interim Re-Analysis; 1979–2015), ERA-40 (1958–2001), NCEP–NCARv1 (National Centers for Environmental Prediction–National Center for Atmospheric Research Reanalysis version 1; 1948–2015), NCEP–NCARv2 (1979–2015), JRA-55 (Japanese 55-year Reanalysis; 1958–2014), 20CRv2(c) (Twentieth Century Reanalysis version 2; 1900–2014) and ERA-20C (1900–2010) reanalyses. While all these forcing products are reanalyses that are assumed to represent the same climate, they produce significant differences in the MAR-simulated SMB over their common period. A temperature adjustment of +1 °C (respectively −1 °C) was, for example, needed at the MAR boundaries with ERA-20C (20CRv2) reanalysis, given that ERA-20C (20CRv2) is ∼ 1 °C colder (warmer) than ERA-Interim over Greenland during the period 1980–2010. Comparisons with daily PROMICE (Programme for Monitoring of the Greenland Ice Sheet) near-surface observations support these adjustments. Comparisons with SMB measurements, ice cores and satellite-derived melt extent reveal the most accurate forcing datasets for the simulation of the GrIS SMB to be ERA-Interim and NCEP–NCARv1. However, some biases remain in MAR, suggesting that some improvements are still needed in its cloudiness and radiative schemes as well as in the representation of the bare ice albedo. Results from all MAR simulations indicate that (i) the period 1961–1990, commonly chosen as a stable reference period for Greenland SMB and ice dynamics, is actually a period of anomalously positive SMB (∼ +40 Gt yr−1) compared to 1900–2010; (ii) SMB has decreased significantly after this reference period due to increasing and unprecedented melt reaching the highest rates in the 120-year common period; (iii) before 1960, both ERA-20C and 20CRv2-forced MAR simulations suggest a significant precipitation increase over 1900–1950, but this increase could be the result of an artefact in the reanalyses that are not well-enough constrained by observations during this period and (iv) since the 1980s, snowfall is quite stable after having reached a maximum in the 1970s. These MAR-based SMB and accumulation reconstructions are, however, quite similar to those from Box (2013) after 1930 and confirm that SMB was quite stable from the 1940s to the 1990s. Finally, only the ERA-20C-forced simulation suggests that SMB during the 1920–1930 warm period over Greenland was comparable to the SMB of the 2000s, due to both higher melt and lower precipitation than normal. [less ▲]

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See detailOrganometallic-mediated radical polymerization of 'less activated monomers': fundamentals, challenges and opportunities
Debuigne, Antoine ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg

in Polymer (2017), 115

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the ... [more ▼]

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the double bond of these monomers. This Feature Article summarizes substantial progress in the organometallic-mediated radical polymerization (OMRP) of this important class of monomers including vinyl esters, olefins, vinyl chloride, vinyl amides, or ionic-liquid vinyl monomers. It aims to provide a clear and comprehensive account of the fundamentals and challenges in the OMRP of LAMs as well as an overview of the resulting macromolecular engineering opportunities. The input of photochemistry, environmentally friendly solvents or flow reactors in OMRP is also presented. Finally, it emphasizes how some well-defined LAMs-based materials contributed to the development of specific applications notably in the fields of biomedicine or energy. [less ▲]

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See detailThe recent warming trend in North Greenland
Orsi, A.; Kawamura, K.; Masson-Delmotte, V. et al

in Geophysical Research Letters (2017)

The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric ... [more ▼]

The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric reanalyses are relatively unconstrained in this region, resulting in a large spread of estimated 30-year recent warming trends, which limits their use to investigate the mechanisms responsible for this trend. Here, we present a surface temperature reconstruction over 1982-2011 at NEEM (51∘ W, 77∘ N), in North Greenland, based on the inversion of borehole temperature and inert gas isotope data. We find that NEEM has warmed by 2.7±0.33∘C over the past 30 years, from the long-term 1900-1970 average of -28.55±0.29∘C. The warming trend is principally caused by an increase in downward longwave heat flux. Atmospheric reanalyses underestimate this trend by 17%, underlining the need for more in situ observations to validate reanalyses. [less ▲]

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See detailVortex Lattice simulations of attached and separated flows around flapping wings
Lambert, Thomas ULg; Abdul Razak, Norizham; Dimitriadis, Grigorios ULg

in Aerospace (2017), 4(2), 22

Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads ... [more ▼]

Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads acting on flapping wings are of interest for designing such aircraft and optimising thrust production. In this work, the unsteady Vortex Lattice method is used in conjunction with three load estimation techniques in order to predict the aerodynamic lift and drag time histories produced by flapping rectangular wings. The load estimation approaches are the Katz, Joukowski and simplified Leishman-Beddoes techniques. The simulations' predictions are compared to experimental measurements from a flapping and pitching wing presented by Razak and Dimitriadis [1]. Three types of kinematics are investigated, pitch-leading, pure flapping and pitch lagging. It is found that pitch-leading tests can be simulated quite accurately using either the Katz or Joukowski approaches as no measurable flow separation occurs. For the pure flapping tests, the Katz and Joukowski techniques are accurate as long as the static pitch angle is greater than zero. For zero or negative static pitch angles these methods underestimate the amplitude of the drag. The Leishman-Beddoes approach yields better drag amplitudes but can introduce a constant negative drag offset. Finally, for the pitch-lagging tests the Leishman-Beddoes technique is again more representative of the experimental results, as long as flow separation is not too extensive. Considering the complexity of the phenomena involved, in the vast majority of cases the lift time history is predicted with reasonable accuracy. The drag (or thrust) time history is more challenging. [less ▲]

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See detailUse of a metagenetic approach to monitor the bacterial microbiota of “Tomme d’Orchies” cheese during the ripening process
Ceugniez, Alexandre; Taminiau, Bernard ULg; Coucheney, Françoise et al

in International Journal of Food Microbiology (2017), 247

The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade ... [more ▼]

The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade, particularly those performed on milk and cheese derivative products. In this work, we investigated the bacterial content of "Tomme d'Orchies" cheese, an artisanal pressed and uncooked French cheese. To this end, a metagenetic analysis, using Illumina technology, was utilized on samples taken from the surface and core of the cheese at 0, 1, 3, 14 and 21 days of ripening process. In addition to the classical microbiota found in cheese, various strains likely from environmental origin were identified. A large difference between the surface and the core content was observed within samples withdrawn during the ripening process. The main species encountered in the core of the cheese were Lactococcus spp. and Streptococcus spp., with an inversion of this ratio during the ripening process. Less than 2.5% of the whole population was composed of strains issued from environmental origin, as Lactobacillales, Corynebacterium and Brevibacterium. In the core, about 85% of the microbiota was attributed to the starters used for the cheese making. In turn, the microbiota of the surface contained less than 30% of these starters and interestingly displayed more diversity. The predominant genus was Corynebacterium sp., likely originating from the environment. The less abundant microbiota of the surface was composed of Bifidobacteria, Brevibacterium and Micrococcales. To summarize, the “Tomme d’Orchies” cheese displayed a high diversity of bacterial species, especially on the surface, and this diversity is assumed to arise from the production environment and subsequent ripening process. [less ▲]

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See detailScaling Theory of the Anderson Transition in Random Graphs: Ergodicity and Universality
Garcia-Mata, Ignacio; Giraud, Olivier; Georgeot, Bertrand et al

in Physical Review Letters (2017), 118

We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that ... [more ▼]

We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that a single transition separates a localized phase from an unusual delocalized phase that is ergodic at large scales but strongly nonergodic at smaller scales. In the critical regime, multifractal wave functions are located on a few branches of the graph. Different scaling laws apply on both sides of the transition: a scaling with the linear size of the system on the localized side, and an unusual volumic scaling on the delocalized side. The critical scalings and exponents are independent of the branching parameter, which strongly supports the universality of our results. [less ▲]

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See detailAssessment of bacterial superficial contamination in classical or ritually slaughtered cattle using metagenetics and microbiological analysis
Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg; Hupperts, Caroline et al

in International Journal of Food Microbiology (2017), 247

The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological ... [more ▼]

The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological procedures and 16S rDNA metagenetics. The purpose was also to investigate the neck area to identify bacteria originating from the digestive or the respiratory tract. Twenty bovine carcasses (10 from each group) were swabbed at the slaughterhouse, where both slaughtering methods are practiced. Two swabbing areas were chosen: one “legal” zone of 1,600 cm2 (composed of zones from rump, flank, brisket and forelimb) and locally on the neck area (200 cm2). Samples were submitted to classical microbiology for aerobic Total Viable Counts (TVC) at 30°C and Enterobacteriaceae counts, while metagenetic analysis was performed on the same samples. The classical microbiological results revealed no significant differences between both slaughtering practices; with values between 3.95 and 4.87 log CFU/100 cm2 and 0.49 and 1.94 log CFU/100 cm2, for TVC and Enterobacteriaceae respectively. Analysis of pyrosequencing data showed that differences in the bacterial population abundance between slaughtering methods were mainly observed in the “legal” swabbing zone compared to the neck area. Bacterial genera belonging to the Actinobacteria phylum were more abundant in the “legal” swabbing zone in “Halal” samples, while Brevibacterium and Corynebacterium were encountered more in “Halal” samples, in all swabbing areas. This was also the case for Firmicutes bacterial populations (families of Aerococcaceae, Planococcaceae). Except for Planococcoceae, the analysis of Operational Taxonomic Unit (OTU) abundances of bacteria from the digestive or respiratory tract revealed no differences between groups. In conclusion, the slaughtering method does not influence the superficial microbiological pattern in terms of specific microbiological markers of the digestive or respiratory tract. However, precise analysis of taxonomy at the genus level taxonomy highlights differences between swabbing areas. Although not clearly proven in this study, differences in hygiene practices used during both slaughtering protocols could explain the differences in contamination between carcasses from both slaughtering groups. [less ▲]

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See detailVers une (r)évolution du renseignement belge : la nécessaire émergence d'une communauté du renseignement
Leroy, Patrick ULg

in Revue "Diplomatie" (2017)

Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles ... [more ▼]

Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles" du renseignement par des mesures radicales qui pourraient atteindre l'ADN, le coeur de métier du renseignement. [less ▲]

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See detailExtracting residues from stone tools for optical analysis: towards an experiment-based protocol
Cnuts, Dries ULg; Rots, Veerle ULg

in Archaeological and Anthropological sciences (2017)

The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they ... [more ▼]

The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they lack distinguishing shapes or easily visible structures under reflected light microscopy. Amorphous residues can only be identified by using transmitted light microscopy, which requires the extraction of residues from the tool’s surface. Residues are usually extracted with a pipette or an ultrasonic bath in combination with distilled water. However, a number of researchers avoid residue extraction because it is unclear whether current extraction techniques are representative for the use-related residue that adheres to a flaked stone tool. In this paper, we aim at resolving these methodological uncertainties by critically evaluating current extraction methodologies. Attention is focused on the variation in residue types, their causes of deposition and their adhesion and on the most successful technique for extracting a range of residue types from the stone tool surface. Based on an experimental reference sample in flint, we argue that a stepwise extraction protocol is most successful in providing rep- resentative residue extractions and in preventing damage, destruction or loss of residue. [less ▲]

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See detailLiver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North America
André, Adrien ULg; Mouton, Alice ULg; millien, virginie et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017)

Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation ... [more ▼]

Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome.We also detected a large proportion of individuals infected by Bartonella vinsonii arupensis, a human pathogenic bacteria responsible for endocarditis, aswell as Borrelia burgdorferi, the pathogen responsible for Lyme disease in North America. We then compared the microbiomes among two P. leucopus genetic clusters occurring on either side of the St. Lawrence River, and did not detect any effect of the host genotype on their liver microbiome assemblage. Finally, we report, for the first time, the presence of B. burgdorferi in a smallmammal host fromthe northern side of the St. Lawrence River, in support of models that have predicted the northern spread of Lyme disease in Canada. [less ▲]

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See detailAzacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects
Ehx, Grégory ULg; Fransolet, Gilles ULg; De Leval, Laurence et al

in Oncoimmunology (2017)

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]

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See detailSubstrate Induced Strain Field in FeRh Epilayers Grown on Single Crystal MgO (001) Substrates
Barton, C. W.; Ostler, Thomas ULg; Huskisson, D. et al

in Scientific Reports (2017), 7

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new ... [more ▼]

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new possibilities for creating multifunctional magnetic and spintronic devices which can utilise both thermal and applied eld energy to change state and functionalise composites. A key requirement in realising multifunctional devices is the need to understand and control the properties of FeRh in the extreme thin lm limit (tFeRh < 10 nm) where interfaces are crucial. Here we determine the properties of FeRh lms in the thickness range 2.5–10 nm grown directly on MgO substrates. Our magnetometry and structural measurements show that a perpendicular strain eld exists in these thin films which results in an increase in the phase transition temperature as thickness is reduced. Modelling using a spin dynamics approach supports the experimental observations demonstrating the critical role of the atomic layers close to the MgO interface. [less ▲]

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULg; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailD’une victime à l’autre: Posture ou (im)posture victimaire?
Garcet, Serge ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

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See detailMicrofossils from the late Mesoproterozoic – early Neoproterozoic Atar/El Mreïti Group, Taoudeni Basin, Mauritania, northwestern Africa
Beghin, Jérémie ULg; Storme, Jean-Yves; Blanpied, Christian et al

in Precambrian Research (2017), 291

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See detailThe Case of the Decaying Cadaver
Stefanuto, Pierre-Hugues ULg; Focant, Jean-François ULg

in The Analytical Scientist (2017), 51

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See detailImpact of tillage on greenhouse gas emissions by an agricultural crop and dynamics of N2O fluxes: Insights from automated closed chamber measurements
Lognoul, Margaux ULg; Theodorakopoulos, Nicolas ULg; Hiel, Marie-Pierre ULg et al

in Soil & Tillage Research (2017), 167

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O ... [more ▼]

Our experiment aimed at studying the impact of long term tillage treatments – reduced tillage (RT) and conventional tillage (CT), on CO2 and N2O emissions by soil and at describing the dynamics of N2O fluxes. Gas measurements were performed from June to October 2015 in a Belgian maize crop, with homemade automated closed chambers, allowing continuous measurement at a high temporal resolution. After 7 years of treatment, CO2 and N2O average emissions were significantly larger in the RT parcel than in the CT parcel. This observation was attributed to the effect of tillage on the distribution of crop residues within the soil profile, leading to higher soil organic C and total N contents and a greater microbial biomass in the upper layer in RT. A single N2O emission peak triggered by a sudden increase of water- filled pore space (WFPS) was observed in the beginning of the measuring campaign. The absence of large emission afterwards was most likely due to a decreasing availability of N as crop grew. N2O background fluxes showed to be significantly correlated to CO2 fluxes but not to WFPS, while the influence of soil temperature remained unclear. Our results question the suitability of reduced tillage as a “climate-smart” practice and suggest that more experiments be conducted on conservation practices and their potent negative effect on environment. [less ▲]

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See detailEtude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute Performance
Mbinze Kindenge, Jérémie ULg; Diallo, Tediane; Yemoa, Loconon ULg et al

in Médecine d'Afrique Noire (2017), 64

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses ... [more ▼]

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses médicaments génériques d’une part, et au fléau des médicaments de qualité inférieure d’autre part, il devient plus que nécessaire d’appuyer les données des tests physico-chimiques par celles de dissolution in vitro dont l’évaluation et la comparaison des cinétiques permettra de prédire le comportement in vivo du principe actif et par conséquent l’efficacité du médicament générique. L’objectif de la présente étude est de réaliser une étude comparative de la cinétique de dissolution d’un princeps et d’un générique à base de quinine comprimé 300 mg commercialisés à Kinshasa. Matériels et méthodes : L’étude a été réalisée en utilisant trois milieux de pH différents (1,2 - 4,5 - 6,8) tels que recommandés par l’Agence Européenne de Médicament et en se servant d’un appareil de dissolution, tandis que l’équipement de chromatographie liquide à haute performance couplée à un détecteur à barrette de diodes a été utilisé pour la quantification. La méthode statistique fit factor a été appliquée pour comparer les résultats de dosage de la quinine dans les trois milieux tout en ayant évalué le biais à différents temps de dissolution. Résultats : Les différents échantillons de médicaments générique et princeps ont été conformes quant à l’identification et au dosage de la quinine, par contre leurs cinétiques de dissolution étaient non similaires. Discussion : Ceci pourrait avoir une influence sur l’efficacité du produit générique et la sécurité des consommateurs, dénotant l’importance d’examiner les profils de dissolution des génériques avant toute autorisation de mise sur le marché plus particulièrement dans les pays en voie de développement. [less ▲]

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See detailOn the identification of paedomorphic and overwintering larval newts based on cloacal shape: review and guidelines
Denoël, Mathieu ULg

in Current Zoology (2017), 63(2), 165-173

Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without ... [more ▼]

Paedomorphosis is an alternative process to metamorphosis in which adults retain larval traits at the adult stage. It is frequent in newts and salamanders, where larvae reach sexual maturity without losing their gills. However, in some populations, larvae overwinter in water, while remaining immature. These alternative ontogenetic processes are of particular interest in various research fields, but have different causes and consequences, as only paedomorphosis allows metamorphosis to be bypassed before maturity. It is thus relevant to efficiently identify paedomorphs versus overwintering larvae. In this context, the aim of this paper was threefold: firstly, to perform a meta-analysis of the identification procedures carried out in the literature; secondly, to determine the effectiveness of body size to make inferences about adulthood by surveying natural newt populations of Lissotriton helveticus and Ichthyosaura alpestris, and thirdly, to propose easy guidelines for an accurate distinction between large larvae and paedomorphs based on an external sexual trait, which is essential for reproduction — the cloaca. More than half of the studies in the literature do not mention the diagnostic criteria used for determining adulthood. The criteria mentioned were the presence of mature gonads (10%), eggs laid (4%), courtship behaviour (10%), and external morphological sexual traits (39%) including the cloaca (24%). Body-size thresholds should not be used as a proxy for paedomorphosis, because overwintering larvae can reach a larger size than paedomorphs within the same populations. In contrast, diagnosis based on cloacal external morphology is recommended, as it can be processed by the rapid visual assessment of all caught specimens, thus providing straightforward data at the individual level for both sexes. [less ▲]

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See detailZonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et al

in FASEB Journal (2017), 31(4), 1678-1688

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the ... [more ▼]

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cytonuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1. Moreover, by using mutated promoter constructs, we identified a NF-κB site as critical in this activation. Furthermore, NF-κB pathway signaling analysis revealed both IκBα and p65 phosphorylation in ZO-1-overexpressing cells, and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction. Investigation of the functional implication of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vivo angiogenesis assays. Finally, we found that non-small-cell lung carcinoma that presented a cytonuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1 expression. Taken together, our results demonstrate that ZO-1 regulates CXCL8/IL-8 expression via the NF-κB signaling pathway and its p65 subunit, which subsequently modulates the transcription of IL-8. We also provide evidence of a newly identified regulatory pathway that could promote angiogenesis. Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment. [less ▲]

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See detailBaelo Claudia dans l'Antiquité tardive. L'occupation du secteur sud-est du forum entre les IIIe et VIe siècles
Brassous, Laurent; Deru, Xavier ULg; Rodríguez Gutiérrez, Oliva et al

in Melanges de la Casa de Velazquez (2017), 47(1), 169-202

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon ... [more ▼]

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon et de réoccupation entre les IIIe et VIe s. Les structures découvertes ainsi que le nombreux mobilier qui leur était associé (monnaies, céramique, verre, métal, faune, etc.) fournissent un éclairage nouveau sur l’histoire et la nature de l’agglomération dans l’antiquité tardive, qui entre la fin du IVe s. et son abandon définitif au VIe s. ressemble moins à une ville qu’à un gros village. [less ▲]

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See detailVille de Liège, reprenez la main ! : politique architecturale de la ville de Liège
De Visscher, Lisa ULg

in A+ : Architecture in Belgium (2017), 265

Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of ... [more ▼]

Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of mutation in Liege, which is why a thorough architectural policy of the City of Liège must make a difference. [less ▲]

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See detailThe ‘male escape hypothesis’: sex-biased metamorphosis in response to climatic drivers in a facultatively paedomorphic amphibian
Mathiron, Anthony; Lena, Jean-Paul; Baouch, Sarah et al

in Proceedings of the Royal Society B : Biological Sciences (2017), 284(1853), 20170176

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and ... [more ▼]

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and metamorphs dispersing. The evolution of these developmental processes is thought to have been driven by the costs and benefits of inhabiting aquatic versus terrestrial habitats. In this context, we aimed at testing the hypothesis that climatic drivers affect phenotypic transition and the difference across sexes because sex-ratio is biased in natural populations. Through a replicated laboratory experiment, we showed that paedomorphic palmate newts (Lissotriton helveticus) metamorphosed at a higher frequency when water availability decreased and metamorphosed earlier when temperature increased in these conditions. All responses were sex-biased, and males were more prone to change phenotype than females. Our work shows how climatic variables can affect facultative paedomorphosis and support theoretical models predicting life on land instead of in water. Moreover, because males metamorphose and leave water more often and earlier than females, these results, for the first time, give an experimental explanation for the rarity of male paedomorphosis (the ‘male escape hypothesis’) and suggest the importance of sex in the evolution of paedomorphosis versus metamorphosis. [less ▲]

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See detailUsefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbreds
Vanderick, Sylvie ULg; Gillon, Alain; Glorieux, Géry et al

in Livestock Science (2017), 198

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]

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See detailAn investigation into the fraction of particle accelerators among colliding-wind binaries. Towards an extension of the catalogue
De Becker, Michaël ULg; Benaglia, Paula; Romero, Gustavo E. et al

in Astronomy and Astrophysics (2017), 600

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact ... [more ▼]

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact with different fields (magnetic or radiation) in the colliding-wind region and produce non-thermal emission. In many cases, non-thermal synchrotron radiation might be observable and thus constitute an indicator of the existence of a relativistic particle population in these multiple systems. To date, the catalogue of PACWBs includes about 40 objects spread over many stellar types and evolutionary stages, with no clear trend pointing to privileged subclasses of objects likely to accelerate particles. This paper aims at discussing critically some criteria for selecting new candidates among massive binaries. The subsequent search for non-thermal radiation in these objects is expected to lead to new detections of particle accelerators. On the basis of this discussion, some broad ideas for observation strategies are formulated. At this stage of the investigation of PACWBs, there is no clear reason to consider particle acceleration in massive binaries as an anomaly or even as a rare phenomenon. We therefore consider that several PACWBs will be detected in the forthcoming years, essentially using sensitive radio interferometers which are capable of measuring synchrotron emission from colliding-wind binaries. Prospects for high-energy detections are also briefly addressed. [less ▲]

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See detail"La madone et la putain": Quand les stéréotypes de genres influencent la perception de la légalité des violences sexuelles et le traitement de la réaction sociale à l'égard des femmes
Garcet, Serge ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des ... [more ▼]

Les illégalités liées au traitement différentiel des genres reposent notamment sur la présence de stéréotypes sexistes. L’article illustre comment les attitudes subjectivement positives à l’égard des femmes que l’on peut qualifier de stéréotypes sexistes bienveillants influencent tant positivement que négativement la façon dont les femmes sont perçues par le système judiciaire. L’article souligne également au travers des représentations liées aux violences sexuelles l’impact des stéréotypes sexistes hostiles sur la perception de la légalité, de la légitimité perçue du passage à l’acte et du statut des victimes. [less ▲]

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See detailRetour sur le délit collectif
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (16), 738-739

La nature réglementaire des infractions de non-paiement de rémunération ne les empêche pas de former un délit collectif

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See detailVitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)
Cianferotti, Luisella; Bertoldo, Francesco; Bischoff-Ferrari, Heike et al

in Endocrine (2017), 56(2), 245-61

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided ... [more ▼]

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., <50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels >50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation. [less ▲]

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See detailThe Semiotics of Design in Media Visualization: Mereology and Observation Strategies
Dondero, Maria Giulia ULg

in Information Design Journal (2017)

The purpose of this paper is to discern in what ways the semiotic methods of the Post- Greimasian French structuralist and the American Peircian traditions can enrich the study of contemporary methods of ... [more ▼]

The purpose of this paper is to discern in what ways the semiotic methods of the Post- Greimasian French structuralist and the American Peircian traditions can enrich the study of contemporary methods of computational analysis of culture, particularly in the field of Cultural Analytics as implemented by the Russian Art Historian and Computer Scientist Lev Manovich. These semiotic approaches will be helpful in understanding what kinds of visualizations are being generated for use in Cultural Analytics, and what kinds of operations the observer must perform in order to experiment with scientific visualizations of this information. [less ▲]

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See detailDFT investigation of the reaction mechanism for the guanidine catalyzed ring-opening of cyclic carbonates by aromatic and alkyl-amines
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in RSC Advances (2017), 7(31), 18993-19001

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the ... [more ▼]

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the aromatic or aliphatic nature of the amine. The structural ability of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to simultaneously give and receive protons was demonstrated by a detailed mechanistic investigation. The bifunctional activity (base/H-bond donor) of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailFrom Loose to Boxed Fragments and Back Again. Seriality and Archive in Chris Ware's ‘Building Stories’
Crucifix, Benoît ULg

in Journal of Graphic Novels and Comics (2017)

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to ... [more ▼]

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to understand its box-of- comics format as well as its fragmented narrative structure. In a self-reflexive homage to the material history of comics, Ware's graphic novel indeed appears as an archive of its own serialization, foregrounding a process of collecting/dispersing fragments. [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailOrganocatalytic coupling of CO2 with a propargylic alcohol: a comprehensive study of the reaction mechanism combining in- situ ATR-IR spectroscopy and DFT calculations
Boyaval, Amélie ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in ChemSusChem (2017), 10(6), 1241-1248

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR ... [more ▼]

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR spectroscopy and DFT calculations. Bicyclic guanidines, namely TBD and MTBD, are effective catalysts for the conversion of 2-methyl-3-butyn-2-ol to α-methylene cyclic carbonate and oxoalkyl acyclic carbonate under mild reaction conditions. The lower selectivity of TBD in comparison with MTBD towards the formation of α-methylene cyclic carbonate was elucidated from DFT calculations and is related to the bifunctional activity (base/H-bond donor) of TBD decreasing the Gibbs free energy of the reaction path for the formation of the acyclic carbonate. Introduction [less ▲]

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See detailOrganocatalytic coupling of CO2 with oxetane
Alves, Margot ULg; Grignard, Bruno ULg; Boyaval, Amélie ULg et al

in ChemSusChem (2017), 10(6), 1128-1138

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on ... [more ▼]

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on the yield, the product formed and the selectivity of the reaction are discussed. An onium salt combined with a fluorinated alcohol promotes the efficient and selective organocatalytic synthesis of α,ω-hydroxyl oligocarbonates by coupling CO2 with oxetanes at 130 °C and at a CO2 pressure as low as 2 MPa. NMR characterizations were correlated with MALDI-ToF analyses for elucidating the structure of the oligomers. Online FTIR studies under pressure, NMR titrations and DFT calculations allowed an in-depth understanding of the reaction mechanism. Finally, CO2- based poly(carbonate-co-urethane)s were synthesized by step- growth polymerization of hydroxyl telechelic oligocarbonates with MDI. The organocatalytic system described in this paper constitutes an innovative sustainable route to the selective preparation of hydroxyl telechelic carbonates, of high interest for many applications, notably for the polyurethane business, especially for coatings or foams. [less ▲]

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See detailKNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies
Abo Al Chamlat, Sinan ULg; Farnir, Frédéric ULg

in BMC Bioinformatics (2017), 18

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely ... [more ▼]

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-wide data due to the intractable difficulties met in searching a combinatorial explosive search space and statistically evaluating epistatic interactions given a limited number of samples. Our work is a contribution to this field. We propose a novel approach combining K-Nearest Neighbors (KNN) and Multi Dimensional Reduction (MDR) methods for detecting gene-gene interactions as a possible alternative to existing algorithms, e especially in situations where the number of involved determinants is high. After describing the approach, a comparison of our method (KNN-MDR) to a set of the other most performing methods (i.e., MDR, BOOST, BHIT, MegaSNPHunter and AntEpiSeeker) is carried on to detect interactions using simulated data as well as real genome-wide data. Results Experimental results on both simulated data and real genome-wide data show that KNN-MDR has interesting properties in terms of accuracy and power, and that, in many cases, it significantly outperforms its recent competitors. Conclusions The presented methodology (KNN-MDR) is valuable in the context of loci and interactions mapping and can be seen as an interesting addition to the arsenal used in complex traits analyses. [less ▲]

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See detailSimultaneous synthesis and chemical functionalization of emulsion-templated porous polymers using nitroxide-terminated macromolecular surfactants
Mathieu, Kevin ULg; De Winter, Julien; Jérôme, Christine ULg et al

in Polymer Chemistry (2017), 8(11), 1850-1861

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in ... [more ▼]

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in tedious multi-steps processes. This work describes a straightforward macromolecular surfactant-assisted method for producing chemically functionalized macroporous polyHIPEs with interconnected structures. Accordingly, high internal phase emulsion-templated polymerizations were implemented in the presence of SG1-terminated amphiphilic copolymers prepared by nitroxide- mediated radical polymerization (NMP). The latter served as both stabilizers and functionalizing agents upon thermal activation of its terminal alkoxyamine and covalent anchoring of the released radical copolymer onto the walls of the scaffold. The effect of the polymerization temperature on the functionalization and openness of the final porous materials was explored. As a result, a range of open-cell styrene and acrylate-based polyHIPEs chemically grafted with PEO were obtained. Moreover, polyHIPEs were also decorated with alkyne-bearing PEO and subsequently modified via CuAAc click chemistry in order to demonstrate the potential of this macromolecular surfactants-assisted functionalization method. [less ▲]

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See detailTranscriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.
tarifeno-Saldiva, estefania; Lavergne, Arnaud ULg; Bernard, Alice et al

in BMC Biology (2017), 15

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the ... [more ▼]

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the different pancreatic cell types has been maintained during vertebrate evolution, the comparison of their transcriptomes across distant vertebrate species is a mean to pinpoint genes under strong evolutionary constrains due to their crucial function and which have preserved their selective expression in these pancreatic cell types. Results In this study, RNA-sequencing was performed on pancreatic alpha-, beta- and delta endocrine cells as well as the acinar and ductal exocrine cells isolated from adult zebrafish transgenic lines. Comparison of these transcriptomes identified many novel markers including transcription factors and signaling pathways components specific for each cell type. By performing interspecies comparisons, we identified hundreds of genes with conserved enriched expression in endocrine and exocrine cells among human, mouse and zebrafish. This list includes many genes known as crucial for pancreatic cell formation or function, but also pinpoints many factors whose pancreatic function is still unknown. A large set of endocrine-enriched genes can already be detected at early developmental stages as revealed by the transcriptomic profiling of embryonic endocrine cells, indicating a potential role in cell differentiation. The actual involvement of conserved endocrine genes in pancreatic cell differentiation was demonstrated in zebrafish for myt1b, whose invalidation leads to a reduction of alpha-cells, and for cdx4, selectively expressed in endocrine delta-cells and crucial for their specification. Intriguingly, comparison of the endocrine alpha- and beta-cell subtypes from human, mouse and zebrafish reveals a much lower conservation of the transcriptomic signatures for these two endocrine cell subtypes compared to the signatures of pan-endocrine and exocrine cells. These data suggest that the identity of the alpha- and beta-cells relies on a few key factors, corroborating numerous examples of inter-conversion between these two endocrine cell subtypes. Conclusion. This study highlights both evolutionary conserved and species-specific features that will help to unveil universal and fundamental regulatory pathways as well as pathways specific to human and laboratory animal models such as mouse and zebrafish. [less ▲]

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See detailUltimate strength of cylindrical shells with cutouts
Eui Lee, Sang; Sahin; Rigo, Philippe ULg et al

in Ships and Offshore Structures (2017)

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See detailInfluence of granular fraction and origin of recycled concrete aggregates on their properties
Zhao, Zengfeng ULg; Courard, Luc ULg; Michel, Frédéric ULg et al

in European Journal of Environmental and Civil Engineering (2017)

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of ... [more ▼]

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of the granular fraction and the origin of RCA on their properties. In this study, RCA from industrial produced blocks (RCA_Blocks) and slabs (RCA_Slabs) were crushed and then separated into four granular fractions (0/2, 2/6.3, 6.3/14, 14/20 mm). Each granular fraction of RCA was physically characterised. Real RCA from recycling plant were also used for comparison. The results showed that recycled sands offered significantly higher cement paste content (higher bound water content) than coarse recycled aggregates. The fine RCA had therefore a higher water absorption coefficient compared to coarser fractions of RCA. The water absorption of finer fraction of RCA could be extrapolated precisely from the relationship between water absorption and cement paste content (or bound water content) of three coarse fractions of RCA. The values of hardened cement paste content obtained for the RCA_Blocks were lower than those measured on the RCA_Slabs, which was due to a smaller amount of initial cement paste content in blocks. The results showed that RCA_Slabs were more angular than RCA_Blocks. [less ▲]

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See detailRNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots.
Liu, Shi; Zainuddin, Ima M.; Vanderschuren, Hervé ULg et al

in Plant Molecular Biology (2017)

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava ... [more ▼]

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava is seriously constrained by the rapid post-harvest physiological deterioration (PPD) of its roots that occurs within 24-72 h of harvest, rendering the roots unpalatable and unmarketable. PPD limits cassava's marketing possibilities in countries that are undergoing increased development and urbanisation due to growing distances between farms and consumers. The inevitable wounding of the roots caused by harvesting triggers an oxidative burst that spreads throughout the cassava root, together with the accumulation of secondary metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abundant. Scopoletin oxidation yields a blue-black colour, which suggests its involvement in the discoloration observed during PPD. Feruloyl CoA 6'-hydroxylase is a controlling enzyme in the biosynthesis of scopoletin. The cassava genome contains a seven membered family of feruloyl CoA 6'-hydroxylase genes, four of which are expressed in the storage root and, of these, three were capable of functionally complementing Arabidopsis T-DNA insertion mutants in this gene. A RNA interference construct, designed to a highly conserved region of these genes, was used to transform cassava, where it significantly reduced feruloyl CoA 6'-hydroxylase gene expression, scopoletin accumulation and PPD symptom development. Collectively, our results provide evidence that scopoletin plays a major functional role in the development of PPD symptoms, rather than merely paralleling symptom development in the cassava storage root. [less ▲]

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See detailStatistics of localized phase slips in tunable width planar point contacts
Baumans, Xavier ULg

in Scientific Reports (2017), 7

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In ... [more ▼]

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In the present work we investigate highly confined phase slips at the contact point of two superconducting leads. Profiting from the high current crowding at this spot, we are able to shrink in-situ the nanoconstriction. This procedure allows us to investigate, in the very same sample, thermally activated phase slips and the probability density function of the switching current I sw needed to trigger an avalanche of events. Furthermore, for an applied current larger than I sw , we unveil the existence of two distinct thermal regimes. One corresponding to efficient heat removal where the constriction and bath temperatures remain close to each other, and another one in which the constriction temperature can be substantially larger than the bath temperature leading to the formation of a hot spot. Considering that the switching current distribution depends on the exact thermal properties of the sample, the identification of different thermal regimes is of utmost importance for properly interpreting the dissipation mechanisms in narrow point contacts. [less ▲]

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See detailModelling of organic Rankine cycle power systems in off-design conditions: an experimentally-validated comparative study
Dickes, Rémi ULg; Dumont, Olivier ULg; Daccord, Rémi et al

in Energy (2017), 123

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development ... [more ▼]

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development, power generation from low-grade heat sources is gaining interest and the organic Rankine cycle (ORC) is seen as one of the most promising technologies for such applications. In this paper, it is proposed to perform an experimentally-validated comparison of different modelling methods for the off-design simulation of ORC-based power systems. To this end, three types of modelling paradigms (namely a constant-efficiency method, a polynomial-based method and a semi-empirical method) are compared both in terms of their fitting and extrapolation capabilities. Post-processed measurements gathered on two experimental ORC facilities are used as reference for the models calibration and evaluation. The study is first applied at a component level (i.e. each component is analysed individually) and then extended to the characterization of the entire organic Rankine cycle power systems. Benefits and limi- tations of each modelling method are discussed. The results show that semi-empirical models are the most reliable for simulating the off-design working conditions of ORC systems, while constant-efficiency and polynomial-based models are both demonstrating lack of accuracy and/or robustness. [less ▲]

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See detailUnderground pumped storage hydropower plants using open pit mines: How do groundwater exchanges influence the efficiency?
Pujades, Estanislao ULg; Orban, Philippe ULg; Bodeux, Sarah ULg et al

in Applied Energy (2017), 190

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of ... [more ▼]

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of groundwater. These exchanges may impact the surrounding aquifers, but they may also influence the efficiency of the pumps and turbines because affecting the head difference between the reservoirs. Despite the relevance for an accurate efficiency assessment, the influence of the groundwater exchanges has not been previously addressed. A numerical study of a synthetic case is presented to highlight the importance of considering the groundwater exchanges with the surrounding porous medium. The general methodology is designed in order to be further applied in the decision making of future UPSH plants introducing each case specific complexity. The underground reservoir of a hypothetical UPSH plant, which consists in an open pit mine, is considered and modelled together with the surrounding porous medium. Several scenarios with different characteristics are simulated and their results are compared in terms of (1) head difference between the upper and lower reservoirs and (2) efficiency by considering the theoretical performance curves of a pump and a turbine. The results show that the efficiency is improved when the groundwater exchanges increase. Thus, the highest efficiencies will be reached when (1) the underground reservoir is located in a transmissive porous medium and (2) the walls of the open pit mine do not constrain the groundwater exchanges (they are not waterproofed). However, a compromise must be found because the characteristics that increase the efficiency also increase the environmental impacts. Meaningful and reliable results are computed in relation to the characteristics of the intermittent and expected stops of UPSH plants. The frequency of pumping and injection must be considered to properly configure the pumps and turbines of future UPSH plants. If not, pumps and turbines could operate far from their best efficiency conditions. [less ▲]

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See detailMacroH2A histone variants maintain nuclear organization and heterochromatin architecture.
Douet, Julien; Corujo, David; Malinverni, Roberto et al

in Journal of Cell Science (2017)

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated ... [more ▼]

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin architecture. Specifically, we find that a substantial amount of macroH2A is associated with heterochromatic repeat sequences. We further identify macroH2A on sites of interstitial heterochromatin decorated by H3K9me3. Loss of macroH2A leads to major defects in nuclear organization including reduced nuclear circularity, disruption of nucleoli and a global loss of dense heterochromatin. Domains formed by repeat sequences when depleted of macroH2A are disorganized, expanded and fragmented and mildly re-expressed. On the molecular level we find that macroH2A is required for the interaction of repeat sequences with the nucleostructural protein Lamin B1. Taken together our results argue that a major function of macroH2A histone variants is to link nucleosome composition to higher order chromatin architecture. [less ▲]

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See detailBehavior of digital sequences through exotic numeration systems
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Electronic Journal of Combinatorics (2017), 24(1), 14436

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied ... [more ▼]

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied using techniques from analytic number theory or linear algebra. In this paper we develop a method based on exotic numeration systems and we apply it on two examples motivated by the study of generalized Pascal triangles and binomial coefficients of words. [less ▲]

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See detailStrategic Points in Aquaponics
Junge, Ranka; König, Bettina; Villarroel, Morris et al

in Water (2017), 9(182),

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See detailPouvoir politique et audace des juges
Grandjean, Geoffrey ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), (1), 231-237

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See detailTwo massive rocky planets transiting a K-dwarf 6.5 parsecs away
Gillon, Michaël ULg; Demory, Brice-Olivier; Van Grootel, Valérie ULg et al

in Nature Astronomy (2017), 1

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of ... [more ▼]

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of these planets, HD 219134 b, whose mass and radius (4.5 M[SUB]⊕[/SUB] and 1.6 R[SUB]⊕[/SUB] respectively) are consistent with a rocky composition[SUP]1[/SUP]. Here, we report new high-precision time-series photometry of the star acquired with Spitzer revealing that the second innermost planet of the system, HD 219134c, is also transiting. A global analysis of the Spitzer transit light curves and the most up-to-date HARPS-N velocity data set yields mass and radius estimations of 4.74 ± 0.19 M[SUB]⊕[/SUB] and 1.602 ± 0.055 R[SUB]⊕[/SUB] for HD 219134 b, and of 4.36 ± 0.22 M[SUB]⊕[/SUB] and 1.511 ± 0.047 R[SUB]⊕[/SUB] for HD 219134 c. These values suggest rocky compositions for both planets. Thanks to the proximity and the small size of their host star (0.778 ± 0.005 R[SUB]⊙[/SUB])[SUP]3[/SUP], these two transiting exoplanets — the nearest to the Earth yet found — are well suited for a detailed characterization (for example, precision of a few per cent on mass and radius, and constraints on the atmospheric properties) that could give important constraints on the nature and formation mechanism of the ubiquitous short-period planets of a few Earth masses. [less ▲]

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See detailWASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b & WASP-142b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with ... [more ▼]

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with [Fe/H] = +0.26. Warm Jupiters tend to have smaller radii than hot Jupiters, and WASP-130b is in line with this trend (1.23 Mjup; 0.89 Rjup). WASP-131b is a bloated Saturn-mass planet (0.27 Mjup; 1.22 Rjup). Its large scale height coupled with the V = 10.1 brightness of its host star make the planet a good target for atmospheric characterisation. WASP-132b is among the least irradiated and coolest of WASP planets, being in a 7.1-d orbit around a K4 star. It has a low mass and a modest radius (0.41 Mjup; 0.87 Rjup). The V = 12.4, [Fe/H] = +0.22 star shows a possible rotational modulation at 33 d. WASP-139b is the lowest-mass planet yet found by WASP, at 0.12 Mjup and 0.80 Rjup. It is a "super-Neptune" akin to HATS-7b and HATS-8b. It orbits a V = 12.4, [Fe/H] = +0.20, K0 star. The star appears to be anomalously dense, akin to HAT-P-11. WASP-140b is a 2.4-Mjup planet in a 2.2-d orbit that is both eccentric (e = 0.047) and with a grazing transit (b = 0.93) The timescale for tidal circularisation is likely to be the lowest of all known eccentric hot Jupiters. The planet's radius is large (1.4 Rjup), but uncertain owing to the grazing transit. The host star is a V = 11.1, [Fe/H] = +0.12, K0 dwarf showing a prominent 10.4-d rotational modulation. The dynamics of this system are worthy of further investigation. WASP-141b is a typical hot Jupiter, being a 2.7 Mjup, 1.2 Rjup planet in a 3.3-d orbit around a V = 12.4, [Fe/H] = +0.29, F9 star. WASP-142b is a typical bloated hot Jupiter (0.84 Mjup, 1.53 Rjup) in a 2.1-d orbit around a V = 12.3, [Fe/H] = +0.26, F8 star. [less ▲]

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