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See detailDetection of differential item functioning using the lasso approach
Magis, David ULg; Tuerlinckx, Francis; De Boeck, Paul

in Journal of Educational & Behavioral Statistics (in press)

This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR ... [more ▼]

This paper proposes a novel approach to detect differential item functioning (DIF) among dichotomously scored items. Unlike standard DIF methods that perform an item-by-item analysis, we propose the “LR lasso DIF method”: logistic regression (LR) model is formulated for all item responses. The model contains item specific intercepts, an effect of the sum score and item-group interaction (i.e. DIF) effects, with a lasso penalty on all DIF parameters. Optimal penalty parameter selection is investigated through several known information criteria (AIC, BIC and cross-validation) as well as through a newly developed alternative. A simulation study was conducted to compare the global performance of the suggested “LR lasso DIF” method to the logistic regression and Mantel-Haenszel methods (in terms of false alarm and hit rates). It is concluded that for small samples the LR lasso DIF approach globally outperforms the logistic regression method, and also the Mantel-Haenszel method, especially in the presence of item impact, while it yields similar results with larger samples. [less ▲]

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See detailRGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification
Huang, Yi-Shiang ULg; Bertrand, Virginie ULg; Bozukova, Dimitriya et al

in PLoS ONE (in press)

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal ... [more ▼]

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient’s age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development. [less ▲]

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See detailSimultaneous enforcement of constraints at position and velocity levels in the nonsmooth generalized-alpha scheme
Bruls, Olivier ULg; Acary, Vincent; Cardona, Alberto

in Computer Methods in Applied Mechanics & Engineering (in press)

This paper presents a formalism for the transient simulation of nonsmooth dynamic mechanical systems composed of rigid and flexible bodies, kinematic joints and frictionless contact conditions. The ... [more ▼]

This paper presents a formalism for the transient simulation of nonsmooth dynamic mechanical systems composed of rigid and flexible bodies, kinematic joints and frictionless contact conditions. The proposed algorithm guarantees the exact satisfaction of the bilateral and unilateral constraints both at position and velocity levels. Thus, it significantly differs from penalty techniques since no penetration is allowed. The numerical scheme is obtained in two main steps. Firstly, a splitting method is used to isolate the contributions of impacts, which shall be integrated with only first-order accuracy, from smooth contributions which can be integrated using a higher order scheme. Secondly, following the idea of Gear, Gupta and Leimkuhler, the equations of motion are reformulated so that the bilateral and unilateral constraints appear both at position and velocity levels. After time discretization, the equations of motion involve two complementarity conditions and it can be solved at each time step using a monolithic semi-smooth Newton method. The numerical behaviour of the proposed method is studied and compared to other approaches for a number of numerical examples. It is shown that the formulation offers a unified and valid approach for the description of contact conditions between rigid bodies as well as between flexible bodies. [less ▲]

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See detailEnjeux politiques et critiques d'une philosophie des normes
Caeymaex, Florence ULg; Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailClostridium difficile infection in elderly nursing home residents.
Rodriguez Diaz, Cristina ULg; Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg et al

in Anaerobe (in press), 23

Age-related changes in intestinal flora and host defences, the receipt of antibiotic treatment, and the presence of underlying diseases are some of the most common risk factors associated with Clostridium ... [more ▼]

Age-related changes in intestinal flora and host defences, the receipt of antibiotic treatment, and the presence of underlying diseases are some of the most common risk factors associated with Clostridium difficile infection. Therefore, retirement care facilities for elderly people have been pinpointed as frequent sources of contamination. There is only limited data regarding the presence and epidemiology of C. difficile in nursing homes, and this gap in the current literature emphasises the need to gain a better understanding of the situation in order to prevent the emergence of new outbreaks among this population group. [less ▲]

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See detailLetter to the Editor.
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Seminars in arthritis and rheumatism (in press)

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See detailThe construction of workers’ rights consciousness through legal intermediations: the case of employment discrimination in Belgium
Lejeune, Aude ULg; Orianne, Jean-François ULg

in International Journal of Discrimination and the Law (in press)

Through their different encounters with union, court, and government equality agency lawyers, workers report diverse understandings of their personal experience of injustice in the workplace. This paper ... [more ▼]

Through their different encounters with union, court, and government equality agency lawyers, workers report diverse understandings of their personal experience of injustice in the workplace. This paper examines workers’ experiences of discrimination and the role legal professionals play in litigating these issues in Belgium. Bringing together legal and rights consciousness studies and the sociology of intermediation and tracking different stages in the construction of discrimination cases, from the moment when a future litigant describes an event as an injustice to the moment when the judge recognises a discriminatory behaviour (or conversely, dismisses a case), we suggest several possible empirical explanations of the way in which interactions with legal intermediaries affect workers’ rights consciousness. Because we refer to socio-legal studies from common law countries, this paper also calls into question how best to import these studies to assist in analysing legal mobilisations and legal consciousness in continental Europe. [less ▲]

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See detailEstablishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation
Binsfeld, Marilène ULg; Beguin, Yves ULg; Belle, Ludovic et al

in PLoS ONE (in press)

Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic ... [more ▼]

Background: Multiple myeloma (MM) is a malignant plasma cell disorder with poor long-term survival and high recurrence rates. Despite evidence of graft-versus-myeloma (GvM) effects, the use of allogeneic hematopoietic stem cell transplantation (allo-SCT) has remained controversial in MM. In the current study, we investigated the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice (previously injected with the MOPC315.BM myeloma cell line), based on a chronic graft-versus-host disease (GvHD) murine model. Methods and results: Balb/cJ mice were injected intravenously with luciferase-transfected MOPC315.BM cells, and received 30 days later an allogeneic (B10.D2 donor) or autologous (Balb/cJ donor) transplantation by intravenous administration of bone marrow cells and splenocytes. We observed a graft-versus-myeloma effect in 94% of the allogeneic transplanted mice, as luciferase signal completely disappeared after transplantation, whereas all the autologous transplanted mice showed myeloma evolution. Lower serum paraprotein levels and myeloma infiltration in bone marrow and spleen in the allogeneic setting confirmed the observed GvM effect, while allogeneic mice also displayed chronic GvHD symptoms. In vivo and in vitro data suggest the involvement of effector memory CD4 and CD8 T cells in the GvM effect. The essential role of CD8 T cells was demonstrated in vivo where CD8 T-cell depletion of the graft resulted in reduced GvM effects. Finally, TCR V spectratyping analysis identified V families within CD4 and CD8 T cells which were associated with both GvM effects and GVHD, whereas other V families within CD4 T cells were associated exclusively with either GvM or GvHD responses. Conclusions: We successfully established an immunocompetent murine model of graft-versus-myeloma. This is the first immunocompetent murine model which is based on a MM model closely resembling human MM disease (bone marrow tropism, ...) and using allo-SCT after the disease establishment, as a curative treatment [less ▲]

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See detailMapping track density changes in nigrostriatal and extranigral pathways in Parkinson's disease
Ziegler, Erik ULg; Rouillard, Maud; André, Elodie et al

in NeuroImage (in press)

Highlights First whole-brain probabilistic tractography study in Parkinson's disease High quality diffusion-weighted images (120 gradient directions, b = 2500 s/mm2) Voxel-based group analysis comparing ... [more ▼]

Highlights First whole-brain probabilistic tractography study in Parkinson's disease High quality diffusion-weighted images (120 gradient directions, b = 2500 s/mm2) Voxel-based group analysis comparing early-stage patients and controls Abnormal reconstructed track density in the nigrostriatal pathway and brainstem Track density also increased in limbic and cognitive circuits. [less ▲]

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See detailA Text Structure Indicator and two Topological Methods: New Ways for Studying Latin Historic Narratives
Longrée, Dominique ULg; Mellet, Sylvie

in International Journal of Corpus Linguistics (in press)

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See detailLes porcheries : réservoirs des culicoïdes (Diptera: Ceratopogonidae), vecteurs des virus de la Maladie de la Langue bleue et de Schmallenberg ?
Zimmer, Jean-Yves ULg; Saegerman, Claude; Martinelle, Ludovic et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailPhénoménologie brentanienne
Dewalque, Arnaud ULg

in Austriaca (in press)

It is usual to think of the spectacular development of the Brentano School in Austria as being tied to the rise of a specific research program, which is sometimes dubbed “Austrian phenomenology”. I ... [more ▼]

It is usual to think of the spectacular development of the Brentano School in Austria as being tied to the rise of a specific research program, which is sometimes dubbed “Austrian phenomenology”. I discuss here some evidences for the existence of such a program. In the discussion, I highlight two claims which I take to be constitutive of the Brentanian phenomenology. The first one is the epistemological claim according to which our concepts all have an empirical origin, which has to be located in the experience we have of our own mental states. The second one is the methodological claim according to which describing a mental phenomenon P is nothing but analysing P, where “analysing P” simply means “distinctly perceiving all the constituents of P”. Although a deeper insight in those two claims would require considerable further investigations, I suggest they should be part of the picture when it comes to adjudicating on the specificity of the Brentanian program. [less ▲]

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See detailOsteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Endocrine (in press)

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of ... [more ▼]

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they could have deleterious effects on the bone. Evidence from longitudinal, crosssectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk. The association between SSRIs use and fracture risk could potentially differ depending on dose, exposure duration, time of exposure, age, or sex. However, the risk of fracture declined rapidly after discontinuation of use of SSRIs. The evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. In practice, assessment of risk factor for osteoporosis or fractures could be made taking into account age, gender, duration, and severity of depression, length of SSRI treatments, and other concurrent risk factors. [less ▲]

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See detailCOMMENT JE TRAITE ... L’arrêt cardio-respiratoire extrahospitalier : la fenêtre du centraliste 112
STIPULANTE, Samuel ULg; ZANDONA, Régine; EL-FASSI, Mehdi ULg et al

in Revue Médicale de Liège (in press), 69

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See detailAllogeneic hematopoietic stem cell transplantation in solid organ transplant recipients: a retrospective, multicenter study of the EBMT
Basak, GW.; Wiktor-Jedrzejczak, W.; Labopin, M. et al

in American Journal of Transplantation (in press)

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in ... [more ▼]

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in recipients of solid organ transplantation (SOT). We investigated 28 patients with malignant (N=22) or nonmalignant diseases (N=6), who underwent 31 alloSCT procedures: 12 after kidney, 13 after liver, and three after heart transplantation. The incidence of solid organ graft failure at 60 months after first alloSCT was 33% (95% confidence interval [CI], 16–51%) for all patients, 15% (95% CI, 2–40%) for liver recipients, and 50% (95% CI, 19–75%) for kidney recipients (p = 0.06). The relapse rate after alloSCT (22%) was low following transplantation for malignant disorders, despite advanced stages of malignancy. Overall survival at 60 months after first alloSCT was 40% (95% CI, 19–60%) for all patients, 51% (95% CI, 16–86%) for liver recipients, and 42% (95% CI, 14–70%) for kidney recipients (p = 0.39). In summary, we show that selected SOT recipients suffering from hematologic disorders may benefit from alloSCT and experience enhanced long-term survival without loss of organ function. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (in press)

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See detailClinical sentinel surveillance of equine West Nile fever, Spain
Saegerman, Claude ULg; Alba-Casals, A; Garcia-Bocanegra, I et al

in Transboundary and Emerging Diseases (in press)

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailAnalysis of shrinkage effect on mass transfer during the convective drying of sawdust/sludge mixtures
Li, Jie; Bennamoun, Lyes; Fraikin, Laurent ULg et al

in Drying Technology (in press)

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See detailEmpirical modelling of the bifurcation behaviour of a bridge deck undergoing across-wind galloping
Andrianne, Thomas ULg; Dimitriadis, Grigorios ULg

in Journal of Wind Engineering & Industrial Aerodynamics (in press)

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order ... [more ▼]

This work presents an empirical model capable to describe the galloping bifurcation behaviour of a bridge deck. It is based on a general polynomial form proposed by Novak, which we limit to the 5th order. The advantage of choosing this function for modelling the vertical force coefficient is that asymmetry of the even terms is enforced in order to reproduce the sub-critical aeroelastic behaviour of the bridge deck. The coefficients of the polynomial are identified from several pairs of displacement amplitudes and the corresponding airspeeds, measured in a wind tunnel during dynamic tests on the sectional bridge model. The identification is carried out using a first order harmonic balance technique. A stability analysis is presented in order to highlight the need of such a model to catch the complete bifurcation behaviour of the system. The resulting force coefficient of this full order model is compared to the well known models of Parkinson and Novak. Finally, the concept universal curve is used in order to discuss the galloping responses of square and rectangular cylinders, in comparison with the one of the bridge deck. [less ▲]

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See detailHigh concentrations of Myeloperoxidase in the equine uterus as an indicator of endometritis
Parrilla Hernandez, Sonia ULg; Ponthier, Jérôme ULg; Franck, Thierry ULg et al

in Theriogenology (in press)

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears ... [more ▼]

Intra-luminal fluid and excessive abnormal hyper-edema are regularly used for the diagnosis of endometritis in the mare, which is routinely confirmed by the presence of neutrophils on endometrial smears. Studies show a relation between neutrophils and myeloperoxidase (MPO), an enzyme contained in and released by neutrophils during degranulation or after cell lysis. This enzyme has been found in many fluids and tissues and associated with different inflammatory pathologies in the horse. The aims of this study were to assess the presence and concentration of MPO in the equine uterus, and to investigate its relation with neutrophils, and other clinical signs of endometritis. Mares (n=51) were evaluated for presence of intra-luminal fluid and excessive endometrial edema before breeding, and a small volume lavage and cytology samples were obtained. From 69 cycles, supernatant of the uterine flushes was analysed with a specific equine MPO ELISA assay to measure MPO concentration. Cytology samples were used for the diagnosis of endometritis. MPO was present in the uterus of all estrus mares in highly variable concentrations. MPO concentrations were significantly (p<0.05) higher in samples with positive cytologies and in presence of intra-luminal fluid. Occasionally, some samples with negative cytologies showed high MPO concentration, but the opposite was never observed. Cycles presenting hyper-edema weren’t associated to high concentration of MPO, intra-luminal fluid or positive cytology making it a poor diagnostic tool of endometritis. [less ▲]

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See detailA note on the equivalence between observed and expected information functions with polytomous IRT models
Magis, David ULg

in Journal of Educational & Behavioral Statistics (in press)

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected ... [more ▼]

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected information functions are equivalent for the class of divide-by-total models (including partial credit, generalized partial credit, rating scale and nominal response models), but not for the class of difference models (including the graded response and modified graded response models). Yet, observed information function remains positive in both classes. Straightforward connections with dichotomous IRT models and further implications are outlined. [less ▲]

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See detailEffect of improved feeding and housing, Friesian blood level and parity on milk production of Ankole x Friesian cows
Kibwana, Denise Katungu; Makumyaviri, A.M.; Hornick, Jean-Luc ULg

in Pakistan Veterinary Journal (in press)

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk ... [more ▼]

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk consumption in population. An improved farming system, including feed supplementation, Friesian cross-breeding and the sheltering of animals in stalls at night, was studied to evaluate its effect on milk production by Ankole x Friesian crossbreds. The study was performed in Beni, D.R. Congo, on two groups of 15 animals (control group-CoG and improved group-IG), homogeneous according to Friesian blood and parity levels. The improved system, Friesian blood and parity levels increased significantly milk production (P<0.001). Farming system increased milk production by 1.6 l/d (5.2 l/d vs 6.8 l/d respectively in CoG and IG). Milk production ranged from 5.3±0.04 l/d to 6.6±0.02 l/d and from 4.9±0.02 l/d to 7.2±0.02 l/d according, respectively, to Friesian blood level and parity. A significant interaction was observed between farming system and Friesian blood level, and between farming system and parity (P<0.001). The two groups were characterized by a fair adaptation to forage availability associated to climatic factors. The study showed the importance of genetic and environmental factors on the milk production of crossbred dairy cows of the region. [less ▲]

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See detailEnvironnements Personnels d’Apprentissage : exploration des représentations et usages d’étudiants de l’enseignement supérieur
Denis, Brigitte ULg; Joris, Noémie ULg

in Sciences et technologies de l'information et de la communication pour l'éducation et la formation (in press)

Currently, it is difficult for a student to pursue higher education without using a digital environment. This leads to the emergence the concept of Personal Learning Environment (PLE). The authors define ... [more ▼]

Currently, it is difficult for a student to pursue higher education without using a digital environment. This leads to the emergence the concept of Personal Learning Environment (PLE). The authors define it and consider his competition or complementarity with the digitals institutional environments. They report exploratory study results on students’ representations about their numeric learning environments and their interests about them. Data comes from questionnaires and interviews. Their analysis shows different profiles related to the PLE. Linking the results to learning theories and aspects of technical and educational design, they propose further investigation and development related to the complementarity of PLE and institutional learning environments (ILE). [less ▲]

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See detailNGOs and female circumcision in Egypt. An anthropological enquiry.
Mescoli, Elsa ULg

in Journal of the Anthropology of the Contemporary Middle East and Central Eurasia (in press)

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the ... [more ▼]

In 1994, during the International Conference on Population and Development convened by the United Nations in Cairo, a shocking video was shown, realized by an operator of CNN and depicting the circumcision of a ten-year-old child living in this very same city. Discourses around female circumcision were not new in Egypt and in the international community, but what was considered as a new episode of a recurrent scandal (not the last one indeed) led to enhance the "war against bad government"[1]. A war fought by means of ideological weapons produced by expert knowledges among which the medical and the feminist ones. The assignment of a value to the state of integrity of the female body and to the women freedom of choice, both designed according to Western canons, led to different actions to “save” Egyptian women. In this context, development agencies fosters a widespread representation of the victim, constituted by the woman mutilated body. Such representation is functional to put in place programs which do not guarantee a freedom of choice, but rather require adherence to another female model, one that defines the "modern" woman. My article, based on ethnographic experience, aims at highlighting the complexity of such dynamics and the role played by humanitarianism within them. Female body becomes the arena where local and international economic powers operate, disregarding a real understanding of the practice, its meanings and its eventual change. ________________________________________ [1] Foucault, Michel. La nascita della clinica. Il ruolo della medicina nella costituzione delle scienze umane, Einaudi, Torino 1969: 48. [less ▲]

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See detailMulticenter implementation of geriatric assessment in Belgian patients with cancer: A survey on treating physicians' general experiences and expectations.
Kenis, Cindy; Heeren, Pieter; Bron, Dominique et al

in Journal of geriatric oncology (in press)

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A ... [more ▼]

OBJECTIVES: The aim of this study is to identify treating physicians' general experiences and expectations regarding geriatric assessment (GA) in older patients with cancer. MATERIALS AND METHODS: A survey was carried out in 9 Belgian hospitals, which participated in a national GA implementation project focusing on older patients with cancer. A newly developed questionnaire was completed by their treating physicians. Data collection comprised of reviewing hospital data, general respondent data, and treating physicians' general experiences and expectations regarding GA. Descriptive statistics were calculated. RESULTS: Eighty-two physicians from 9 hospitals participated. The GA team composition can vary substantially, with a nurse as core member. Ideally, all older patients with cancer in whom a treatment decision is necessary, should benefit from the GA. Nearly all GA domains are reported as very important. Availability of GA results can be improved. Treating physicians want geriatricians to coordinate geriatric recommendations related to the identified GA problems, and expect from trained healthcare workers (THCWs) to collect GA data, to report GA results, and to follow-up the implementation of geriatric recommendations. CONCLUSION: This study identifies relevant information for improving the implementation of GA in older patients with cancer in Belgium and reveals priorities for a THCW from the treating physician's point of view. To increase the effectiveness of GA, further efforts are needed to improve the implementation of geriatric recommendations. [less ▲]

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See detailGlobal Power after the post-Cold War: the case of Chinese Power
Wintgens, Sophie ULg

in Revista Brasileira de Politica Internacional (in press)

The pre-eminence of the realistic conception has long locked the field of study of the power in International Relations, which is nowadays highly questioned. The analysis of some “new powers” emergence is ... [more ▼]

The pre-eminence of the realistic conception has long locked the field of study of the power in International Relations, which is nowadays highly questioned. The analysis of some “new powers” emergence is as such a tremendous learning experience. In order to go beyond the classical antagonism between the institutional perspectives (cooperation) and the realistic ones (rivalry), this paper deals with the power in an alternative way, from a heterodox approach of hegemony, which allows us to make out the phenomena of insidious and not felt so domination. Following the example of China, committed to building a status of world power, sustained by a self-legitimizing discourse abounding with Third-World overtones (anti-hegemonism, multipolarization of the world, South-South cooperation, etc.), the increase in its global influence does not only depend on the availability of its – tangible and intangible – resources, nor on its ability to mobilize them adequately (smart power). China also values the image that it has of itself (self-perception), the image that it tends to convey on the international stage (representation), as well as the perception of its status by the other actors of the international system (external recognition). The power of China is measured through its capacity to “assert itself as a reference” for its emerging peers, or even for Western powers. [less ▲]

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See detailThe strength of multi-row models
Louveaux, Quentin ULg; Poirrier, Laurent; Salvagnin, Domenico

in Mathematical Programming Computation (in press)

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a ... [more ▼]

We develop a method for computing facet-defining valid inequalities for any mixed-integer set PJ. Our practical implementation does not return only facet- defining inequalities, but it is able to find a separating cut whenever one exists. The separator is not comparable in speed with the specific cutting-plane generators used in branch-and-cut solvers, but it is general-purpose. We can thus use it to compute cuts derived from any reasonably small relaxation PJ of a general mixed- integer problem, even when there exists no specific implementation for computing cuts with PJ. Exploiting this, we evaluate, from a computational perspective, the usefulness of cuts derived from several types of multi-row relaxations. In particular, we present results with four different strengthenings of the two-row intersection cut model, and multi-row models with up to fifteen rows. We conclude that only fully-strengthened two-row cuts seem to offer a significant advantage over two-row intersection cuts. Our results also indicate that the improvement obtained by going from models with very few rows to models with up to fifteen rows may not be worth the increased computing cost. [less ▲]

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See detailEarly neuropsychological detection of Alzheimer's disease
Bastin, Christine ULg; Salmon, Eric ULg

in European Journal of Clinical Nutrition (in press)

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See detailDevelopment by the sol–gel process of highly dispersed Ni–Cu/SiO2 xerogel catalysts for selective 1,2-dichloroethane hydrodechlorination into ethylene
Pirard, Sophie ULg; Mahy, Julien ULg; Pirard, Jean-Paul ULg et al

in Microporous and Mesoporous Materials (in press)

Ni–Cu/SiO2 xerogel catalysts have been synthesized by cogelation of industrial tetraethoxysilane (Dynasil) and chelates of Ni and Cu with industrial 3-(2-aminoethylamino)propyltrimethoxysilane (Dynasylan ... [more ▼]

Ni–Cu/SiO2 xerogel catalysts have been synthesized by cogelation of industrial tetraethoxysilane (Dynasil) and chelates of Ni and Cu with industrial 3-(2-aminoethylamino)propyltrimethoxysilane (Dynasylan DAMO) in industrial ethanol denatured with diethyl phthalate. Despite the use of industrial grade reagents, highly dispersed bimetallic Ni–Cu/SiO2 xerogel catalysts were obtained. These samples are composed of completely accessible Ni–Cu alloy crystallites with sizes of 1.6–3.4 nm located inside silica particles exhibiting a monodisperse microporous distribution. It appears that the bimetallic complex acts as a nucleation agent in the formation of silica particles. The combination of results obtained from the calculation of the metal ratio in catalysts, H2 chemisorption and transmission electron microscopy allowed calculating the surface composition of the nickel–copper particles in Ni–Cu/SiO2 cogelled xerogel catalysts. Values obtained indicate a very pronounced surface enrichment with copper. While 1,2-dichloroethane hydrodechlorination over pure nickel mainly produces ethane, increasing copper content in bimetallic catalysts results in an increase in ethylene selectivity. The specific consumption rate of 1,2-dichloroethane decreases when copper loading increases. The turnover frequency, that is, the number of catalytic cycle per active site (nickel atom and its surrounding copper atoms) and per second, seems to be independent of surface composition of alloy particles. [less ▲]

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See detailThe potential impact of animal protein intake on global and central obesity: evidence from the ORISCAV-LUX study
Alkerwi, A.; Sauvageot, Nicolas ULg; Buckley, J.D. et al

in Public Health Nutrition (in press)

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See detailKepler detection of a new extreme planetary system orbiting the subdwarf-B pulsator KIC 10001893
Silvotti, R.; Charpinet, S.; Green, E.M. et al

in Astronomy and Astrophysics (in press)

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See detailPhylogeny, classification and species delimitation in the liverwort genus Odontoschisma (Cephaloziaceae)
Aranda, S.C.; Gradstein, S.R.; Patino, J. et al

in Taxon (in press)

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See detailWorking memory deficits in developmental dyscalculia: the importance of serial order.
Attout, Lucie ULg; Majerus, Steve ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (in press)

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See detailThe neural basis of temporal order processing in past and future thought
D'Argembeau, Arnaud ULg; Jeunehomme, Olivier ULg; Majerus, Steve ULg et al

in Journal of Cognitive Neuroscience (in press)

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See detailAboveground biomass mapping of African forest mosaics using canopy texture analysis: towards a regional approach.
Bastin, Jean-François ULg; Barbier, Nicolas; Couteron, Pierre et al

in Ecological Applications (in press)

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity ... [more ▼]

In the context of the reduction of greenhouse gas emissions caused by deforestation and forest degradation (the REDD+ program), optical very high resolution (VHR) satellite images provide an opportunity to characterize forest canopy structure and to quantify aboveground biomass (AGB) at less expense than methods based on airborne remote sensing data. Among the methods for processing these VHR images, Fourier textural ordination (FOTO) presents a good potential to detect forest canopy structural heterogeneity and therefore to predict AGB variations. Notably, the method does not saturate at intermediate AGB values as do pixelwise processing of available space borne optical and radar signals. However, a regional scale application requires to overcome two difficulties: (i) instrumental effects due to variations in sun-scene-sensor geometry or sensor-specific responses that preclude the use of wide arrays of images acquired under heterogeneous conditions and (ii) forest structural diversity including monodominant or open canopy forests, which are of particular importance in Central Africa. In this study, we demonstrate the feasibility of a rigorous regional study of canopy texture by harmonizing FOTO indices of images acquired from two different sensors (Geoeye-1 and QuickBird-2) and different sun-scene-sensor geometries and by calibrating a piecewise biomass inversion model using 26 inventory plots (1 ha) sampled across very heterogeneous forest types. A good agreement was found between observed and predicted AGB (RSE=15%; R²=0.85; p-value<0.001) across a wide range of AGB levels from 26 Mg/ha to 460 Mg/ha, and was confirmed by cross validation. A high-resolution biomass map (100 m pixels) was produced for a 400 km² area, and predictions obtained from both imagery sources were consistent with each other (r=0.86; slope=1.03; intercept=12.01 Mg/ha). These results highlight the horizontal structure of forest canopy as a powerful descriptor of the entire forest stand structure and heterogeneity. In particular, we show that quantitative metrics resulting from such textural analysis offer new opportunities to characterize the spatial and temporal variation of the structure of dense forests and may complement the toolbox used by tropical forest ecologists, managers or REDD+ national monitoring, reporting and verification bodies. [less ▲]

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See detailWhen women support the patriarchal family. The dynamics of marriage in a Gécamines mining camp (Katanga province, DR Congo)
Rubbers, Benjamin ULg

in Journal of Historical Sociology (in press)

Based on ethnographic research among the ex-Gécamines workers of Panda (Likasi, DR Congo), this article studies the dynamics of the spousal relationship in a post-industrial context that has been long ... [more ▼]

Based on ethnographic research among the ex-Gécamines workers of Panda (Likasi, DR Congo), this article studies the dynamics of the spousal relationship in a post-industrial context that has been long characterized by paternalism. The results of this research suggest that, though men and women living in this mining community talk about their spousal relationships by invoking the ideal of Christian marriage promoted during the colonial period, in practice such relationships faced important changes following Congolese independence in 1960. The nationalization and subsequent dramatic decline of Gécamines caused changes which directly affected three central dimensions of the colonial family model, namely monogamy, the ideal of domesticity, and male authority. If men and women continue to reference this model, it is because, in times of growing poverty, it allows spouses to remind one other of their respective duties as docile housewives and responsible husbands, and to command respect as virtuous Christian families in the local community. [less ▲]

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See detailDes intentions aux actes : la volition en conseil d'orientation
Broonen, Jean-Paul ULg

in L'Orientation Scolaire et Professionnelle (in press)

A model limited to motivation construct to explain the way from setting a vocational goal to its achievement cannot claim to give an account of how to overcome regulatory problems during goal striving. A ... [more ▼]

A model limited to motivation construct to explain the way from setting a vocational goal to its achievement cannot claim to give an account of how to overcome regulatory problems during goal striving. A model linking volition to motivation is needed. In particular, implementation intentions have been proved to be effective in helping the initiation of goal striving, shielding goal pursuit from unwelcome influences, and disengagement from not successful courses of action. It is proposed to extend the application of this volitional cognitive tool to career counselling. [less ▲]

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See detailNutritive value of Adenodolichos rhomboideus leaves compared with Leucaena leucocephala and Stylosanthes guianensis forages in indigenous goats in Lubumbashi (DR Congo).
Tshibangu, Muamba Innocent; Nsahlai, Ignatus Verla; Kiatoko, Mangeye Honoré et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

Forage from three species (Adenodolichos rhomboideus, Leucaena leucocephala, Stylosanthes guianensis) were evaluated by determining chemical composition, voluntary intake and apparent in vivo ... [more ▼]

Forage from three species (Adenodolichos rhomboideus, Leucaena leucocephala, Stylosanthes guianensis) were evaluated by determining chemical composition, voluntary intake and apparent in vivo digestibility of dry matter (DM), organic matter (OM), crude protein (CP), neutral detergent fibre (NDF) and acid detergent fibre (ADF). Six goats (17.1±0.7 kg) were used in 3 x 3 double latin square design to determine the digestibility and intake of the three forages. Forage from S. guianensis had lower (p<0.001) CP content than L. leucocephala forage and A. rhomboideus leaves. Fibres content (ADF and NDF) were lower (p<0.001) in L. leucocephala (35%) forage than A. rhomboideus (59.5%) leaves and S. guianensis forages (56.5%). L. leucocephala forage was superior in CP, Ash, EE concentrations, digestibility and voluntary intake of CP. A. rhomboideus leaves had lower (p<0.05) apparent digestibility and intake of DM. Digestible CP intake were similar between A. rhomboideus leaves and S. guianensis forages. Low digestibility and voluntary intake of A. rhomboideus leaves may be due to negative effect of anti-nutritional factor such as tannin. Digestible CP was similar for A. rhomboideus leaves and S. guianensis forage. [less ▲]

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See detailMontage et résistance du réel chez S. Kracauer: Photographie, cinéma, texte.
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in Bulletin d'Analyse Phénoménologique (in press)

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage » ... [more ▼]

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage », notamment dans le champ cinématographique, en ouvrant la réflexion par cette double question : comment définir un « mauvais usage » du montage et, à l’opposé, comment peuvent se mettre en place les conditions d’un « bon usage » du montage selon Kracauer ? Pour y répondre, les auteurs identifient d'abord, dans l’œuvre de Kracauer, les éléments explicites et implicites (montage textuel) qui permettent de saisir au plus près ce que serait, selon le philosophe et sociologue, le principe de réalité. Ensuite, une œuvre photographique, contemporaine des quelques textes évoqués, Menschen des 20. Jahrhunderts d’August Sander, permet de mieux circonscrire les possibles concrétisations de cette pensée en la mettant à l’épreuve d’une réalisation en images et en montage. [less ▲]

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See detailIn situ investigation of scCO2 assisted impregnation of drug into polymer by high pressure FTIR micro-spectroscopy
Champeau, Mathilde ULg; Thomassin, Jean-Michel ULg; Jérôme, Christine ULg et al

in Analyst (in press)

An original experimental set-up combining a FTIR microscope with a high pressure cell has been built in order to analyze in-situ the impregnation of solute into microscopic polymer samples, such as fibers ... [more ▼]

An original experimental set-up combining a FTIR microscope with a high pressure cell has been built in order to analyze in-situ the impregnation of solute into microscopic polymer samples, such as fibers or films, subjected to supercritical CO2. Thanks to this experimental set-up, key factors governing the impregnation process can be simultaneously followed such as the swelling of the polymeric matrix, the CO2 sorption, the kinetic of impregnation and the drug loading into the matrix. Moreover, the solute/polymer interactions and the speciation of the solute can be analyzed. We have monitored in situ the impregnation of aspirin and ketoprofen into PEO (Polyethylene Oxide) platelets at T=40°C and P=5; 10 and 15 MPa. The kinetic of impregnation of aspirin was quicker than the one of ketoprofen and the final drug loading was also higher in case of aspirin. Whereas the CO2 sorption and the PEO swelling remain constant when PEO is just subjected to CO2 under isobaric conditions, we noticed that both parameters can increase while the drug impregnates PEO. Coupling these results with DSC measurements, we underlined the plasticizing effect of the drug that also leads to decrease the crystallinity of PEO in situ thus favoring the sorption of CO2 molecules into the matrix and the swelling of the matrix. The plasticizing effect increases with the drug loading. Finally, the speciation of drug was investigated considering the shift of the carboxyl bands of the drugs. Both drugs were found to be mainly homogeneously dispersed into PEO. [less ▲]

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See detailThiamine triphosphate: a ubiquitous molecule in search of a physiological role
Bettendorff, Lucien ULg; Wins, Pierre

in Metabolic Brain Disease (in press)

Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a ... [more ▼]

Thiamine triphosphate (ThTP) was discovered over 60 years ago and it was long thought to be a specifically neuroactive compound. Its presence in most cell types, from bacteria to mammals, would suggest a more general role but this remains undefined. In contrast to thiamine diphosphate (ThDP), ThTP is not a coenzyme. In E. coli cells, ThTP is transiently produced in response to amino acid starvation, while in mammalian cells, it is constitutively produced at a low rate. Though it was long thought that ThTP was synthesized by a ThDP:ATP phosphotransferase, more recent studies indicate that it can be synthesized by two different enzymes: (1) adenylate kinase 1 in the cytosol and (2) FoF1-ATP synthase in brain mitochondria. Both mechanisms are conserved from bacteria to mammals. Thus ThTP synthesis does not seem to require a specific enzyme. In contrast, its hydrolysis is catalyzed, at least in mammalian tissues, by a very specific cytosolic thiamine triphosphatase (ThTPase), controlling the steady-state cellular concentration of ThTP. In some tissues where adenylate kinase activity is high and ThTPase is absent, ThTP accumulates, reaching ≥ 70% of total thiamine, with no obvious physiological consequences. In some animal tissues, ThTP was able to phosphorylate proteins, and activate a high-conductance anion channel in vitro. These observations raise the possibility that ThTP is part of a still uncharacterized cellular signaling pathway. On the other hand, its synthesis by a chemiosmotic mechanism in mitochondria and respiring bacteria might suggest a role in cellular energetics. [less ▲]

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See detailBryophytes diversified slowly but surely since the mid-Mesozoic
Laenen, B.; Shaw, B.; Schneider, H. et al

in Nature Communications (in press)

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See detailRituximab therapy for hairy cell leukemia : a retrospective study of 41 cases
Leclerc, Mathieu; Suarez, Felipe; Noël, Marie-Pierre et al

in Annals of Hematology (in press)

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and ... [more ▼]

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 centers in France and Belgium, who received 49 treatment courses with the anti-CD20 monoclonal antibody rituximab. Most of the patients were treated at relapse (84 % of cases) and rituximab was combined to a PA in 41 % of cases. Overall, response rate is 90 % including 71 % complete hematologic responses (CHRs). Frontline treatment, combination therapy, and absolute neutrophil count were associated with response in multivariate analysis. Three-year relapse-free and overall survivals are 68 and 90 %, respectively. When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy. In contrast, response rate is only 82 % (59 % CHR) when rituximab is used alone. In this latter setting, relapse rate is 56 % and median time to relapse is 17.5 months. All eight patients who were treated two times with the antibody responded again to retreatment. We confirm the high efficacy of the combination rituximab + PA. However, when rituximab is used as monotherapy, response rate is lower and the high relapse rate is a concern. Prospective clinical trials are needed to confirm the superiority of the combination rituximab + PA over PA alone, both as frontline therapy and at relapse. [less ▲]

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See detailSputum cytokines levels in patients undergoing hematopoietic SCT (HSCT) and comparison with healthy subjects and COPD: a pilot study
MOERMANS, Catherine ULg; BONNET, Christophe ULg; WILLEMS, Evelyne ULg et al

in Bone Marrow Transplantation (in press)

Patients undergoing hematopoietic stem cell transplantation (HSCT) display an airway neutrophilic inflammation before the transplantation that persists over the years. In this study, we have investigated ... [more ▼]

Patients undergoing hematopoietic stem cell transplantation (HSCT) display an airway neutrophilic inflammation before the transplantation that persists over the years. In this study, we have investigated the cytokine profile over a period of one year in sputum supernatant of patients who underwent HSCT. We have measured sputum supernatant levels of TNF-α, TGF-β1, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17, and IFN-γ in 49 HSCT patients and compared the results with those found in 40 COPD and 54 healthy subjects matched for age. Compared to healthy subjects, before the transplantation, HSCT patients exhibited raised levels of IL-6 (p<0.001) and IL-8 (p<0.05) while the other cytokines were generally poorly detectable. This picture was rather similar to what is seen in COPD even if cytokine levels were much greater in the latter with IL-8 being significantly greater in COPD than in HSCT patients (p<0.0001). In the 1 year following the transplantation, sputum IL-6 and IL-8 did not differ any longer compared to healthy subjects. Overall in HSCT patients, sputum IL-8 and IL-6 correlated with sputum neutrophil counts (r=0.4, p<0.0001; r=0.42, p<0.0001, respectively). In conclusion, sputum IL-6 and IL-8 may play a role in neutrophilic airway inflammation seen in patients undergoing HSCT. [less ▲]

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See detailDocument Kinetic study of volatile oil of Curcuma longa L. rhizome and Carum carvi L. fruits extracted by microwave-assisted techniques using the cryogrinding
Akloul, R; Benkaci-Ali, F; Eppe, Gauthier ULg

in Journal of Essential Oil Research (in press)

Hydrodistillation assisted by microwave (HDAM) and steam distillation assisted by microwave (SDAM) of Curcuma longa L. rhizome (CL) and Carum carvi fruits (CC) were investigated. The effect of the ... [more ▼]

Hydrodistillation assisted by microwave (HDAM) and steam distillation assisted by microwave (SDAM) of Curcuma longa L. rhizome (CL) and Carum carvi fruits (CC) were investigated. The effect of the cryogrinding (CG) showed differences in yields and composition of volatile oils compared with classical grinding. HDAM–CG (CL: 1.20%, CC: 1.25%) and SDAM–CG (CL: 1.45%, CC: 1.75%) allowed extraction of substantial amounts of volatile oils in less time compared with HDAM (CL: 0.6%, CC: 1.00%) and SDAM (CL: 0.90%, CC: 1.00%). In addition, the major amounts of volatile oils were globally obtained during the first 5 and 10 minutes of extraction for CL and CC, respectively. A kinetic study of essential oils extraction from CL and CC was quantitatively performed. The composition of the major components and family classes present a significant variation with the extraction time. Essential oils extracted by these two methods were quantitatively (yield) and qualitatively [aromatic profile by gas chromatography (GC) and GC–mass spectrometry (GC–MS)] analyzed. There were differences, especially in the major compounds ar-turmerone (HDAM: 46.00–57.96%, HDAM–CG: 30.85–60.32%) and β-turmerone (HDAM: 14.43–16.74%, HDAM–CG: 10.46–15.77%) for CL, and limonene (HDAM: 23.61–56.97%, HDAM–CG: 38.04–43.00%) and carvone (HDAM: 36.19–64.54%, CC–CG: 53.65–56.31%) for CC. [less ▲]

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See detailAberrations chromatiques : de l’émulsion au pixel
Thonon, Jonathan ULg

in Cahiers Louis Lumière (in press)

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la ... [more ▼]

Dans l’une de ses conversations avec Joachim Gasquet sur le sens de sa peinture (et de la peinture en général), Cézanne aborde de front la conception qu’il se fait de la couleur, dans son rapport à la profondeur picturale et de son articulation à la surface : « La nature n'est pas en surface ; elle est en profondeur. Les couleurs sont l'expression, à cette surface, de cette profondeur. Elles montent des racines du monde ». Cet « organisme de couleurs » que constitue le monde est transcrit dans la peinture de Cézanne par une dynamique symbiotique de la couleur et du dessin, de la ligne et du pan. La couleur restitue, par sa masse, son surgissement, son homogénéité, presque sa viscosité, la véritable chaire perceptive du monde ; une vision qui tient à distance la perspective géométrique, photographique, cinématographique fondée sur la transparence et qui repose, comme le signale Merleau-Ponty, sur la « réversibilité des dimensions » (surface-profondeur) et l’entrelacement des choses. C’est cette épaisseur du visible rendu par la couleur que l’économie de l’image numérique nous permet de redécouvrir, moins dans le registre de la « tactilité » de l’image et la picturalité du pixel, que par l’intégration, entre le support et l’image (parfois indiscernables dans le régime optique), d’un « corps » algorithmique qui règle l’actualisation du visible. Certains défauts techniques du dispositif numérique, aujourd’hui élevés au rang de pratique artistique, permettent de révéler cette matrice qui utilise alors la couleur et la coulure comme mode de visibilité. C’est le cas du Datamoshing, technique de composition numérique qui revisite tout en la radicalisant la pratique de l’incrustation vidéo. Basée sur la perturbation volontaire d’éléments de la matrice, cette technique transforme les couleurs en une forme malléable et fluide révélant ainsi leur double nature spatiale : elles sont à la fois dans l’espace de l’image et l’espace de l’image lui-même. Ces expériences de défigurations d’images s’inscrivent dans le registre des « aberrations chromatiques » dont nous proposons ici une rapide généalogie avant d’interroger la couleur digitale dans ses spécificités. [less ▲]

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See detailInstitutional Investors, Information Asymmetry, Stock Market Liquidity
Sougné, Danielle ULg; Aymen, Ajina; Faten, Lakhal

in International Journal of Managerial Finance (in press), 11

Purpose. The purpose of this study is to examine the effect of institutional investors ownership and activism on information asymmetry and stock market liquidity in France. Design/methodology/approach ... [more ▼]

Purpose. The purpose of this study is to examine the effect of institutional investors ownership and activism on information asymmetry and stock market liquidity in France. Design/methodology/approach. Our sample includes 162 French-listed firms over a period ranging from 2007 to 2009. Our methodology relies on linear regressions using the method of ordinary least square(OLS). Befor examining the interaction between liquidity and institutional investors, we check for the existence of the endogeneity problem by applying the Durbin-Wu_Hausman test of Davidson and MacKinnon (1993). The results of the endogeneity test show that institutional investor ownership and stock liquidity are endogenous. A simultaneous equation model using the second least square method is then tested to address this problem. Findings The findings show that the proportion of institutional investors has a positive and significant effect on stock-market liquidity, which confirms the signal theory and trading hypothesis. These investors perform high trading activity which favourably affect market liquidity. The results suggests that pension funds manage huge assets decreasing transaction costs and improving liquidity. They display a positive signal to the market about more transparency and a low level of information asymmetry.These results highlight the institutional investors'role in defining the level of liquidity of assets on the French market. Our findings also stress the importance of developing institutional investors'demand for the Paris market in order to better assess firms'values, protect minority ownership and improve market liquidity. Originality/Value In the French institutional setting, institutional investors act as a control device since minority shareholder interests are less protected than in Anglo-American counterparts. This result highlights the significant rôle of institional investors in corporate governance structures and a finacila markets. Their prsence is a guarantee for minority interest protection and for improving market liquidity. [less ▲]

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See detailDietary early-life exposure to contaminated eels does not impair spatial cognitive performances in adult offspring mice as assessed in the Y-maze and the Morris water maze
Dridi, ImenI; Leroy, Delphine; Guignard, Cedric et al

in Nutrition Research (in press)

Many environmental contaminants are introduced via the diet and may act as neurotoxins and endocrine disrupters, especially influencing growing organisms in early life. The purpose of this study was to ... [more ▼]

Many environmental contaminants are introduced via the diet and may act as neurotoxins and endocrine disrupters, especially influencing growing organisms in early life. The purpose of this study was to examine whether dietary exposure of dams to fish naturally contaminated with xenobiotics, especially with polychlorinated biphenyls (PCBs) and heavy metals (e.g. mercury and lead), resulted in cognitive function deficits in adult offspring mice. Daily, four groups of dams (n = 10/group) ingested standard diet plus paste with/without eels, during gestation and lactation, from gestational day (GD) six until post natal day (PND) 21 (weaning). Dams orally ingested a standardized amount of eel (0.8 mgkg-1 d-1) containing the six non-dioxin-like (NDL) PCBs (σ6 NDL-PCBs: 28, 52, 101, 138, 153, and 180) at 0, 85, 216, and 400 ngkg-1 d-1. Results showed that early-life exposure to contaminated eels did not (compared to non-exposed controls) impair immediate working memory in the Y-maze in the offspring assessed at PND 38. Furthermore, it did not significantly impact spatial learning and retention memory as measured in the Morris water maze in adult offspring mice (PND 120-123). Our results suggest that perinatal exposure to contaminated eels does not affect spatial cognitive performances, as assessed by the Y-maze and Morris water maze at adult age. Adverse effects of xenobiotics reported earlier might be camouflaged by beneficial eel constituents, such as n-3 fatty acids. However, additional studies are needed to differentiate between potential positive and negative effects following consumption of food items both rich in nutrients and contaminants. © 2014 Elsevier Inc. [less ▲]

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See detailInfluence of COMT Genotype on Antero-Posterior Cortical Functional Connectivity Underlying Interference Resolution
Jaspar, Mathieu ULg; Manard, Marine ULg; DIDEBERG, Vinciane ULg et al

in Cerebral Cortex (in press)

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val158Met) has received increasing attention as a possible modulator of executive functioning and its neural correlates. However, this attention has generally centred on the prefrontal cortices because of the well-known direct impact of COMT enzyme on these cerebral regions. In this study, we were interested in the modulating effect of COMT genotype on anterior and posterior brain areas underlying interference resolution during a Stroop task. More specifically, we were interested in the functional connectivity between the right inferior frontal operculum (IFop), an area frequently associated with inhibitory efficiency, and posterior brain regions involved in reading/naming processes (the two main non-executive determinants of the Stroop effect). The Stroop task was administered during fMRI scanning to three groups of 15 young adults divided according to their COMT Val158Met genotype [Val/Val (VV), Val/Met (VM) and Met/Met (MM)]. Results indicate greater activity in the right IFop and the left middle temporal gyrus (MTG) in homozygous VV individuals than in Met allele carriers. In addition, the VV group exhibited stronger positive functional connectivity between these two brain regions and stronger negative connectivity between the right IFop and left lingual gyrus. These results confirm the impact of COMT genotype on frontal function. They also strongly suggest that differences in frontal activity influence posterior brain regions related to a non-executive component of the task. Especially, changes in functional connectivity between anterior and posterior brain areas might correspond to compensatory processes for performing the task efficiently when the available dopamine level is low. [less ▲]

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See detailError analysis of generalized-alpha Lie group time integration methods for constrained mechanical systems
Arnold, Martin; Bruls, Olivier ULg; Cardona, Alberto

in Numerische Mathematik (in press)

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order ... [more ▼]

Generalized-alpha methods are very popular in structural dynamics. They are methods of Newmark type and combine favourable stability properties with second order convergence for unconstrained second order systems in linear spaces. Recently, they were extended to constrained systems in flexible multibody dynamics that have a configuration space with Lie group structure. In the present paper, the convergence of these Lie group methods is analysed by a coupled one-step error recursion for differential and algebraic solution components. It is shown that spurious oscillations in the transient phase result from order reduction that may be avoided by a perturbation of starting values or by index reduction. Numerical tests for a benchmark problem from the literature illustrate the results of the theoretical investigations. [less ▲]

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See detailSoil contamination near a former Zn-Pb ore-treatment plant: Evaluation of deterministic factors and spatial structures at the landscape scale
Liénard, Amandine ULg; Brostaux, Yves ULg; Colinet, Gilles ULg

in Journal of Geochemical Exploration (in press)

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account ... [more ▼]

Historical soil contamination within a 3 km radius of a former ore treatment plant was evaluated. A total of 247 topsoil samples were collected in a stratified random sampling design taking into account three factors: land use (LU), soil type (ST) and wind direction (WD). Concentrations of trace elements (Cd, Co, Cr, Cu, Ni, Pb and Zn) and major elements (Ca, Mg, K, Fe, Al, Mn) as well as various soil properties (pHwater, pHKCl, TOC and N) were measured. Total Cd, Pb and Zn concentrations were higher than typical background values. Enrichment factors for these three metals were, respectively, 260, 77.4 and 35.5. Principal components analysis (PCA) and factor analysis segregated anthropogenic contamination as a premier factor in influencing concentrations, followed by a second lithogenic factor. The anthropogenic origin of substantial contamination was confirmed though mapping of sample locations relative to contaminant sources. Factor 1 (26.5% of the variance) impacts a large area around the contaminated site and is also indicative of WD influence. Factor 2 (23.9% of the variance) is naturally linked to the local lithology and geology. LU and soil fertility are, respectively, represented by factor 3 (16.5% of the variance), which is linked to pH, and factor 4 (9.3% of the variance), related to organic content. The significance of landscape factors in the spatial distribution of metallic trace elements (MTE) was assessed with an ANCOVA using “distance to the source” as a covariate. Results of the analysis support the hypothesis that Cd, Cu, Pb and Zn concentrations are mainly driven by anthropogenic factors, specifically historical industrial activity at the former ore treatment plant. The ANCOVA also provides a means to quantify the impact of LU and ST as well, particularly on MTE availability in soils. The presence of MTE in soil poses known, and potentially significant, risks to both human health and the environment. [less ▲]

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See detailEVALUATION OF A RAPID BEDSIDE SCORING SYSTEM FOR MICROCIRCULATION VIDEOS ACQUIRED FROM DOGS
Gommeren, Kris ULg; Allerton, Fergus; Morin, Elise et al

in Journal of Veterinary Emergency and Critical Care (in press)

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See detailA mysterious giant ichthyosaur from the lowermost Jurassic of Wales
Martin, Jeremy E; Vincent, Peggy; Suan, Guillaume et al

in Acta Palaeontologica Polonica (in press)

Ichthyosaurs rapidly diversified and colonised a wide range of ecological niches during the Early and Middle Triassic period, but experienced a major decline in diversity near the end of the Triassic ... [more ▼]

Ichthyosaurs rapidly diversified and colonised a wide range of ecological niches during the Early and Middle Triassic period, but experienced a major decline in diversity near the end of the Triassic. Timing and causes of this demise and the subsequent rapid radiation of the diverse, but less disparate, parvipelvian ichthyosaurs are still unknown, notably because of inadequate sampling in strata of latest Triassic age. Here, we describe an exceptionally large radius from Lower Jurassic deposits at Penarth near Cardiff, South Wales (UK) the morphology of which places it within the giant Triassic shastasaurids. A tentative total body size estimate, based on a regression analysis of various complete ichthyosaur skeletons, yields a value of 12-15 m. The specimen is substantially younger than any previously reported last known occurrences of shastasaurids and implies a Lazarus range in the lowermost Jurassic for this ichthyosaur morphotype. [less ▲]

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See detailTheoretical power spectra of mixed modes in low-mass red giant stars
Grosjean, Mathieu ULg; Dupret, Marc-Antoine ULg; Belkacem, Kevin et al

in Astronomy and Astrophysics (in press)

CoRoT and Kepler observations of red giant stars revealed very rich spectra of non-radial solar-like oscillations. Of particular interest was the detection of mixed modes that exhibit significant ... [more ▼]

CoRoT and Kepler observations of red giant stars revealed very rich spectra of non-radial solar-like oscillations. Of particular interest was the detection of mixed modes that exhibit significant amplitude, both in the core and at the surface of the stars. It opens the possibility of probing the internal structure from their innermost layers up to their surface throughout their evolution on the red giant branch, as well as on the red clump. Our objective is primarily to provide physical insight into the mechanism responsible for mixed-mode amplitudes and lifetimes. Subsequently, we aim at understanding the evolution and structure of red-giant spectra along with their evolution. The study of energetic aspects of these oscillations is also important for predicting the mode parameters in the power spectrum. Non-adiabatic computations, including a time-dependent treatment of convection, are performed and provide the lifetimes of radial and non-radial mixed modes. We then combine these mode lifetimes and inertias with a stochastic excitation model that gives us their heights in the power spectra. For stars representative of CoRoT and Kepler observations, we show under which circumstances mixed modes have heights comparable to radial ones. We stress the importance of the radiative damping in determining the height of mixed modes. Finally, we derive an estimate for the height ratio between a g-type and a p-type mode. This can thus be used as a first estimate of the detectability of mixed modes. [less ▲]

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See detailA Systematic Review of Cost-Effectiveness Analyses of Drugs for Postmenopausal Osteoporosis.
Hiligsmann, Mickaël ULg; Evers, Silvia M.; Ben Sedrine, Wafa et al

in PharmacoEconomics (in press)

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal ... [more ▼]

BACKGROUND: Given the limited availability of healthcare resources and the recent introduction of new anti-osteoporosis drugs, the interest in the cost effectiveness of drugs in postmenopausal osteoporosis remains and even increases. OBJECTIVE: This study aims to identify all recent economic evaluations on drugs for postmenopausal osteoporosis, to critically appraise the reporting quality, and to summarize the results. METHODS: A literature search using Medline, the National Health Service Economic Evaluation database and the Cost-Effectiveness Analysis Registry was undertaken to identify original articles published between January 1, 2008 and December 31, 2013. Studies that assessed cost effectiveness of drugs in postmenopausal osteoporosis were included. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was used to assess the quality of reporting of these articles. RESULTS: Of 1,794 articles identified, 39 studies fulfilled the inclusion criteria. They were conducted in 14 different countries and nine active interventions were assessed. When compared with no treatment, active osteoporotic drugs were generally cost effective in postmenopausal women aged over 60-65 years with low bone mass, especially those with prior vertebral fractures. Key drivers of cost effectiveness included individual fracture risk, medication adherence, selected comparators and country-specific analyses. Quality of reporting varied between studies with an average score of 17.9 out of 24 (range 7-21.5). CONCLUSION: This review found a substantial number of published cost-effectiveness analyses of drugs in osteoporosis in the last 6 years. Results and critical appraisal of these articles can help decision makers when prioritizing health interventions and can inform the development of future economic evaluations. [less ▲]

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See detailCompte rendu de l'ouvrage de C. E. Barrett, "Egyptianizing Figurines from Delos. A Study in Hellenistic Religion"
Veymiers, Richard ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (in press), 27

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See detailMoyens et enjeux d’une approche didactique des Illuminations
Saint-Amand, Denis ULg

in Parade Sauvage (in press), 25

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See detailDynamiques transactionnelles de reconnaissance et professionnalisation des stagiaires : perspectives pour la formation initiale
Dejean, Karine ULg

in Education et Formation (in press)

Cet article prend appui sur une recherche doctorale. A partir de l’analyse de récits d’expériences marquantes, à forte charge émotionnelle, rapportées par des enseignants débutants, des schémas ... [more ▼]

Cet article prend appui sur une recherche doctorale. A partir de l’analyse de récits d’expériences marquantes, à forte charge émotionnelle, rapportées par des enseignants débutants, des schémas d’intelligibilité de ces situations vécues ont été construits. Ceux-ci rendent compte des transformations identitaires et émotionnelles des enseignants débutants au travers des dynamiques transactionnelles de reconnaissance. Ces résultats ouvrent des perspectives pour la formation initiale des enseignants et l’accompagnement des enseignants débutants. Les schémas d’intelligibilité pourront être utilisés dans une démarche de réflexivité pour faciliter le décodage de situations professionnelles à forte charge émotionnelle vécues par l’enseignant et l’aider à donner sens à ses expériences [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (in press)

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (in press)

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailPrévention et promotion de la santé : quels modèles pour soutenir l’évolution des pratiques en soins de santé primaires ?
Vanmeerbeek, Marc ULg; Mathonet, Julien; Miermans, Marie-Christine ULg et al

in Presse Médicale (in press)

Objectives Published operating models about preventive health care and health promotion in primary care were sought with the aim of 1) compiling a functional inventory; and 2) to formulate working ... [more ▼]

Objectives Published operating models about preventive health care and health promotion in primary care were sought with the aim of 1) compiling a functional inventory; and 2) to formulate working hypotheses for the improvement of clinical practice towards more efficiency and more equity. Methods Narrative literature review, using keywords related to the various prevention classes, health promotion, primary care, practice models and health care delivery. The diversity of models led to a multi-criteria analysis. Results Twelve models were selected. Their characteristics were unevenly distributed. The models, whose authors announce that they apply to prevention, mainly describe approaches that focus on individuals within physician-patient relationship, and take into account practice organization. Some socio ecological and systems models illustrate health promotion: educational practice, group- or population-based targets, community environment and social determinants of health. There is little room for patients in elaborating the models, as they have little role in health care systems. The definitions of prevention, health promotion and patient education greatly differ from one model to another. Discussion Little is known about practical implementation of the models; assessment data are scarce. Some elements valued by health promotion could be integrated to health care: empowerment of citizens, addressing community environment; increased involvement in local health professionals’ networks; integration of individual and collective approaches within the same health care facilities to address simultaneously individual customization, efficiency and equity objectives. Conclusion These developments may call for adaptation in vocational training and continuous professional development: communication skills, awareness to public health concepts, and early and longitudinal exposure to community-based learning experiences for students. [less ▲]

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See detailL’acte incendiaire, son sujet et sa signification : propositions à partir du Saint Genet de Jean-Paul Sartre
Englebert, Jérôme ULg

in Annales Médico-Psychologiques (in press)

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the ... [more ▼]

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the infractional acting and its social meaning. Methods After recalling the basic notions of international literature about fire setters (including confusion with pyromania, diagnostic problems proposed by the DSM IV and the concept of "communicative arson"), we propose phenomenological and existential clues to discuss the act and its meaning. It is the unlawful act that is analysed and more specifically the arson. We propose different analysis than the psychic causality which is inspired by psychoanalysis. The criminogenesis gives way to a questioning of identity, about the place of fire in the subject’s history and within its relationships to others. As proposed by Sartre, the paradigm of this research is to consider the meaning "as the return of the future in the present". The second field of this study is an analysis of three clinical cases. These cases are the result of a forensic practice. The method is focused on the analysis of a narrative and autobiographical production. By this way we studied the temporal process of these three arsonists. Results A comparative reading of the psychobiography of Jean Genet written by Sartre and of the situation of arsonists gives accurate information. The "criminogenesis" gives way to a questioning of identity. In this way we discuss the meaning of fire in the subject's history and within its relationship to others. We highlight the inscription of the act in the social and constitutive process of the individual. From the clinical material, the author demonstrates a link between arson and construction of identity. Identity is considered as a dialectic between “ipse” and “idem”, as suggested by Ricœur. We can therefore consider the real sense that the arson has from the perspective of the actor but also from the viewpoint of the society and these conceptions may be similar or different. In clinical practice, we recommend to pay special attention to how the fire is part of the biography of the patient. Conclusions The fascination for fire is a source of meaning which can be radically different depending on whether we consider the external interpreter (the world or the clinician) or the author of the action. The basic principles of hermeneutics, as described by Gadamer and Ricœur, are to demonstrate that the understanding and the interpretation are not only the methods used in the human sciences but are also part of the fundamental processes inherent in human nature. Hermeneutics in general is the opposite of a doctrine of truth. It rather seeks to show arbitrarily how the interpretation and the search for meaning are paradigmatic of the human experience. [less ▲]

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See detailRôle et langue de Tchantchès dans les représentations en castelets des romans de chevalerie : le cas des Quatre fils Aymon
Baiwir, Esther ULg; Impe, Anaëlle

in Enquêtes du Musée de la Vie Wallonne (in press)

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du ... [more ▼]

Pourquoi et dans quelle mesure les montreurs de marionnettes liégeoises font-ils intervenir Tchantchès aux côtés des grands chevaliers médiévaux, dont les aventures constituent une part importante du répertoire liégeois ? Quels sont ses moyens d'action, mais également ses modes d'expression ? Divers registres de langue apparaissent au fil des spectacles ; quels sont ceux prêtés à notre héros ? Et surtout, ce rôle et cette langue ont-ils évolué au fil du temps ? C’est à ces quelques questions que nous tentons de répondre, en observant les différentes interventions de Tchantchès dans les réécritures des aventures des quatre fils Aymon, l’une des œuvres les plus anciennes et les plus fréquemment jouées dans les théâtres liégeois dévolus aux comédiens de bois. [less ▲]

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See detailLe Laboratoire d’Analyse statistique des langues anciennes : cinquante années de recherches
Longrée, Dominique ULg

in Etudes Classiques (Namur, Belgium) (in press)

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See detail"Lo no dicho en 'Corazón de Kaláshnikov', de Alejandro Páez Varela. Personajes, causalidades, parataxis."
Vanden Berghe, Kristine ULg

in Literatura mexicana. Revista semestral del centro de estudios literarios. (in press), 25(2),

A stylistic analysis of Corazón de Kaláshnikov (2009) by Alejandro Páez Varela highlights that the novel is extremely elliptic: the focalization of the characters is external, the causal relations are ... [more ▼]

A stylistic analysis of Corazón de Kaláshnikov (2009) by Alejandro Páez Varela highlights that the novel is extremely elliptic: the focalization of the characters is external, the causal relations are implicit and the style is very much paratactic. This seems to correspond to an ethical choice for not participating in the sensationalist representations of the violence in Ciudad Juárez, an option Páez Varela shares with the Bolaño of 2666, specifically the part about the femicides. At the same time, Corazón de Kaláshnikov seems to be typical of a certain style practiced in the north of Mexico, tense and sober, and related to a peculiar geographic and climatic environment. [less ▲]

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See detailSequential decision-making approach for quadrangular mesh generation
Johnen, Amaury ULg; Ernst, Damien ULg; Geuzaine, Christophe ULg

in Engineering with Computers (in press)

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art ... [more ▼]

A new indirect quadrangular mesh generation algorithm which relies on sequential decision-making techniques to search for optimal triangle recombinations is presented. In contrast to the state-of-art Blossom-quad algorithm, this new algorithm is a good candidate for addressing the 3D problem of recombining tetrahedra into hexahedra. [less ▲]

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See detailDevonian antiarch placoderms from Belgium revisited
Olive, Sébastien ULg

in Acta Palaeontologica Polonica (in press)

Anatomical, systematic, and paleobiogeographical data on the Devonian antiarchs from Belgium are reviewed, updated and completed thanks to new data from the field and re-examination of paleontological ... [more ▼]

Anatomical, systematic, and paleobiogeographical data on the Devonian antiarchs from Belgium are reviewed, updated and completed thanks to new data from the field and re-examination of paleontological collections. The material of Bothriolepis lohesti Leriche, 1931 is enhanced and the species better described. An undetermined species of Bothriolepis is recorded from the Famennian of Modave (Liège Province), one species of Asterolepis redescribed from the Givetian of Hingeon and another one described from the Givetian of Mazy (Namur Province). Grossilepis rikiki sp. nov. is recorded from the Famennian tetrapod-bearing locality of Strud (Namur Province) and from the Famennian of Moresnet (Liège Province). It is the first occurrence of Grossilepis after the Frasnian and on the central southern coast of the Euramerican continent. Its occurrence in the Famennian of Belgium may be the result of a late arrival from the Moscow Platform and the Baltic Depression, where the genus is known from Frasnian deposits. Remigolepis durnalense sp. nov. is described from the Famennian of Spontin near Durnal (Namur Province). Except for the doubtful occurrence of Remigolepis sp. in Scotland, this is the first record of this genus in Western Europe. Its occurrence in Belgium reinforces the strong faunal affinities between Belgium and East Greenland and the hypothesis of a hydrographical link between the two areas during the Late Devonian. [less ▲]

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See detailLes ambiguïtés de l’anthropomorphisme : de la divinité agissante à sa statue dans la céramique grecque
Collard, Hélène ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (in press)

L’image, sous ses divers aspects, a joué un rôle essentiel dans la vie des anciens Grecs, en particulier dans le domaine religieux, puisque elle était l’une des modalités de perception du divin. En Grèce ... [more ▼]

L’image, sous ses divers aspects, a joué un rôle essentiel dans la vie des anciens Grecs, en particulier dans le domaine religieux, puisque elle était l’une des modalités de perception du divin. En Grèce, la figuration anthropomorphe des dieux est largement majoritaire. Toutefois, en se tournant vers un support particulier, le vase peint, et un type de représentation particulier, la statue divine, on montrera ici que l’anthropomorphisme a pu amener une certaine ambiguïté. Dans la céramique, les représentations de statues fonctionnent sur plusieurs modes, selon la chronologie. C’est ce que l’on propose d’analyser, en examinant un groupe de vases décorés d’un thème semblable et sur lesquels une divinité est représentée, mais soit sous la forme d’une figure « vivante », soit d’une statue plus ou moins bien caractérisée. Cette étude permettra d’aborder les concepts de « fixité » et de « mouvement » de/dans l’image, mais aussi d’explorer quelques pistes de réflexions sur l’image divine et, plus largement, sur les modes de représentation du divin en Grèce ancienne. [less ▲]

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See detailLa sécurité affective chez l'enfant en milieu résidentiel : Des soins du corps au bien être émotionnel
Aprile, Pauline ULg; Englebert, Jérôme ULg; Gauthier, Jean-Marie ULg

in Evolution Psychiatrique (in press)

Objectives - This review studies the concept of affective security in children living outside of their family environment by a brief exposition of its practical illustration in institution. We want to ... [more ▼]

Objectives - This review studies the concept of affective security in children living outside of their family environment by a brief exposition of its practical illustration in institution. We want to show that sufficient affective security can be achieved even in children institutionalized with major attachment difficulties. Method - We will first examine the original meaning of the concept by a theoretical review of its evolution over the years in the literature. Then, we will consider various questions concerning the legitimacy of institutionalization in link with affective security through a case analysis illustrating the issue. We will finally end by mentioning the main practical implications about the optimization of affective security in children institutionalized. Results - It is foremost by the predictable and expected daily acts posed by the professional caregivers in institution that the child may find sufficient affective security, generating emotional well-being and ultimately, an overall adequate development. Discussion – Children early separated from their family home to be placed in residential institution most often suffer from serious difficulties in terms of attachment to others. In this context, the institution has to deal with a specifically challenge: that is, to help the child to (re-)find sufficient internal security to allow him to grow on solid foundations. The institutional life which replaces family life primarily consists of an organizational structure that seeks to make child life as predictable as possible so that it has the necessary daily benchmarks to evolve adequately. Conclusion – In the everyday life in institution, the professionals struggling with children’s attachment disorders constantly try to achieve a right emotional-body balance through their psycho-educational practices with the child deprived of secure attachment strategies. [less ▲]

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See detailRationale for the potential use of mesenchymal stromal cells in liver transplantation
Vandermeulen, M.; DE ROOVER, Arnaud ULg; BRIQUET, Alexandra ULg et al

in World Journal of Gastroenterology (in press)

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See detailLa flexicurité : une politique des idées ? Regards croisés d’acteurs institutionnels belges en 2013
Beuker, Laura ULg; Gérard, Julie ULg; Orianne, Jean-François ULg

in Revue Belge de Sécurité Sociale (in press)

Cette recherche porte sur la traduction, en Belgique, d’une politique européenne de l’emploi – la flexicurité – par différents acteurs institutionnels. À partir d’une analyse documentaire et d’une ... [more ▼]

Cette recherche porte sur la traduction, en Belgique, d’une politique européenne de l’emploi – la flexicurité – par différents acteurs institutionnels. À partir d’une analyse documentaire et d’une vingtaine d’entretiens semi-directifs, nous étudierons la manière dont ces acteurs s’approprient et interprètent la flexicurité. Nous nous appuierons principalement sur les apports récents de la sociologie de l’action publique, en particulier l’approche cognitive des politiques publiques (Surel, 2000 ; Muller et Surel, 1998) et l’européanisation des politiques d’emploi (Palier et Surel, 2007 ; 2010). Nous montrerons que cette appropriation a donné lieu, en Belgique, à une transformation du sens conféré à la sécurité, dorénavant assimilée à de la flexibilité. [less ▲]

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See detailInternet facilite-t-il chez les étudiants du supérieur un apprentissage de plus en plus autorégulé ?
Poumay, Marianne ULg

in Revue Internationale des Technologies en Pédagogie Universitaire (in press)

The article specifies the meaning of “self-regulated learning”, then illustrates, first in course then in a program, a few practices using Internet as a support for learning. It underlines in those ... [more ▼]

The article specifies the meaning of “self-regulated learning”, then illustrates, first in course then in a program, a few practices using Internet as a support for learning. It underlines in those practices the growing importance of self-regulated learning. It advocates for supporting, mentoring the students in their development of that self-regulation, often implicit and considered granted in the Internet based course environments. [less ▲]

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See detailBayesian inference for transportation origin–destination matrices: the Poisson–inverse Gaussian and other Poisson mixtures
Perrakis, Konstantinos; Karlis, Dimitris; Cools, Mario ULg et al

in Journal of the Royal Statistical Society. Series A Statistics in Society (in press)

Transportation origin–destination analysis is investigated through the use of Poisson mixtures by introducing covariate-based models which incorporate different transport modelling phases and also allow ... [more ▼]

Transportation origin–destination analysis is investigated through the use of Poisson mixtures by introducing covariate-based models which incorporate different transport modelling phases and also allow for direct probabilistic inference on link traffic based on Bayesian predictions. Emphasis is placed on the Poisson–inverse Gaussian model as an alternative to the commonly used Poisson–gamma and Poisson–log-normal models. We present a first full Bayesian formulation and demonstrate that the Poisson–inverse Gaussian model is particularly suited for origin–destination analysis because of its desirable marginal and hierarchical properties. In addition, the integrated nested Laplace approximation is considered as an alternative to Markov chain Monte Carlo sampling and the two methodologies are compared under specific modelling assumptions. The case-study is based on 2001 Belgian census data and focuses on a large, sparsely distributed origin–destination matrix containing trip information for 308 Flemish municipalities. [less ▲]

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See detailInfluence of the Transfer Climate and Job Attitudes on the Transfer Process: Modelling the Direct and Indirect Effects
Peters, Stéphanie ULg; Cossette, Michel; Bates, Reid et al

in Journal of Personnel Psychology (in press)

This study investigates the impact job satisfaction, job involvement, organizational commitment and transfer climate on the training transfer process. Training transfer refers to the application of the ... [more ▼]

This study investigates the impact job satisfaction, job involvement, organizational commitment and transfer climate on the training transfer process. Training transfer refers to the application of the new learning and to performance at work. A two-time data collection was implemented among employees of a public health insurance company who attended professional training programs (N=118). Data analysis revealed that (1) job involvement negatively influenced transfer; (2) peer support positively influenced transfer; (3) openness to change had a negative relationship with transfer; and (4) these three predictors have an indirect effect on performance at work. [less ▲]

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See detailCT SCAN FEATURES OF PRESUMPTIVE HAEMORRHAGIC STROKE IN A DOG WITH CUSHING’S DISEASE
Liotta, Annalisa Pia ULg; Cavrenne, Romain; Peeters, Dominique ULg et al

in Case reports in Veterinary Medicine (in press)

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See detailPLACE DE LA GERIATRIE DANS LA FILIERE DES SOINS
PETERMANS, Jean ULg

in Revue Médicale de Liège (in press)

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See detailBayesian penalized smoothing approaches in models specified using affine differential equations with unknown error distributions
Jaeger, Jonathan ULg; Lambert, Philippe ULg

in Journal of Applied Statistics (in press)

A full Bayesian approach based on ODE-penalized B-splines and penalized Gaussian mixture is proposed to jointly estimate ODE-parameters, state function and error distribution from the observation of some ... [more ▼]

A full Bayesian approach based on ODE-penalized B-splines and penalized Gaussian mixture is proposed to jointly estimate ODE-parameters, state function and error distribution from the observation of some state functions involved in systems of affine differential equations. Simulations inspired by pharmacokinetic studies show that the proposed method provides comparable results to the method based on the standard ODE-penalized B-spline approach (i.e. with the Gaussian error distribution assumption) and outperforms the standard ODE-penalized B-splines when the distribution is not Gaussian. This methodology is illustrated on the Theophylline dataset. [less ▲]

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See detailRéformer la « justice de proximité ». Une comparaison entre les tribunaux coutumiers et les tribunaux de paix à Lubumbashi (R.D.Congo)
Rubbers, Benjamin ULg; Gallez, Emilie

in Critique Internationale (in press)

Dans le cadre de la stratégie des bailleurs de fonds pour restaurer un « Etat de droit » en R.D. Congo, le gouvernement de J. Kabila, élu en 2006, s’est engagé dans une importante réforme du système ... [more ▼]

Dans le cadre de la stratégie des bailleurs de fonds pour restaurer un « Etat de droit » en R.D. Congo, le gouvernement de J. Kabila, élu en 2006, s’est engagé dans une importante réforme du système judiciaire. L’une des principales ambitions de cette réforme est d’améliorer l’accès des citoyens à la justice « moderne » en remplaçant les tribunaux coutumiers par des tribunaux de paix. Basé sur une recherche collective conduite en 2010, cet article propose d’évaluer la portée de ce volet de la réforme en comparant le mode de fonctionnement concret des tribunaux coutumiers à la périphérie de Lubumbashi avec celui des tribunaux de paix dans cette même ville. Cette approche n’autorise pas seulement une critique empiriquement fondée des présupposés modernistes qui sous-tendent la réforme. Elle offre également, à une plus large échelle, un angle d’analyse original pour revenir sur le débat relatif aux systèmes de justice formels/informels qui s’est développé dans la littérature en « law and development » au cours de cette dernière décennie. [less ▲]

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See detailThe ideology of the British National Party
Jamin, Jérôme ULg

in Revue LISA : Littératures, Histoire des Idées, Images, Sociétés du Monde Anglophone = LISA e-Journal (in press)

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See detailDevelopment of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Silva, Joana M.; Vandermeulen, Gaëlle; Oliveira, Vanessa G. et al

in Nanomedicine (in press)

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based ... [more ▼]

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based nanoparticles and mannose-grafted nanoparticles were formulated and physicochemically characterized. Immortalized and primary antigen-presenting cells were used to study nanoparticle internalization patterns. The endocytic pathways and intracellular trafficking followed by nanoparticles were also investigated. Results & discussion: Nanoparticles displayed mannose residues available for binding at the nanoparticle surface. Different nanoparticle internalization patterns by immortalized and primary antigen presenting cells were verified. Macropinocytosis, clathrin-mediated endocytosis, caveolin- and lipid raft-dependent endocytosis are involved in nanoparticles internalization. Nanoparticles demonstrate both endo-lysosomal and cytosolic localizations and a tendency to accumulate nearby the endoplasmic reticulum. Conclusion & future perspective: The developed nanoparticles might drive antigens to be presented through MHC class I and II molecules to both CD8+ and CD4+ T cells, favoring a complete and coordinated immune response. [less ▲]

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See detailThe “Tuchlein” Colours in the Strasbourg Family Text: Recipes for Anthocyanin Pigments
Neven, Sylvie ULg; Sanyova, Jana

in Dyes in History and Archaeology (in press)

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULg

in Revista Natureza Humana (in press)

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See detailEL TLC UE – Colombia – Perú y la integración regional latinoamericana. ¿Hacia una norteamericanización de la estrategia interregional europea?
Parra Santamaria, Lusmiriam Andrea ULg

in Comentario Internacional (in press)

This document compares the contents of the Free Trade Agreements (FTA) that have been signed by the European Union and by the United States with Colombia. It analyses them from a perspective that ... [more ▼]

This document compares the contents of the Free Trade Agreements (FTA) that have been signed by the European Union and by the United States with Colombia. It analyses them from a perspective that characterizes FTAs into “WTO-extra” and “WTO-plus” agreements. By this analysis, an “Americanization” of the European interregional strategy is partially verified. Nevertheless, this “Americanization” appears to be partial, due to the inclusion of “regional integration” as a transversal theme in European FTA. [less ▲]

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See detailSemiótica de la acción: textualización y notación
Dondero, Maria Giulia ULg

in Tópicos del seminario (2015), 31

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining ... [more ▼]

Our essay focuses on some methodological issues concerning the semiotic analysis of practice. We will initially retrace the debate about the epistemological relationship between text and action, outlining the forms of enunciative praxis through different levels of pertinence analysis. Secondly, we propose the concept of ‘textualization’ as a mediation between text and action: textualizations (photographs, videos, notes) organize and represent practices which are in themselves ephemeral and elusive. Finally, we will consider the textual diagrammatization that we call ‘notation’: this analytical form of mediation between text and practice does not have the same status of in-vivo textualisations, but it works like an ex-post reconstruction which highlights the main gestures and exchanges while performing their grammaticalization. A more general aim of this essay is an enquiry into the legitimate objects of textual semiotics: what are the objects that it can analyze without betraying its principle of immanence, but also without being confined to it and, as a consequence, being unable to analyze practices and respond to topical questions on social issues and on the research in the human sciences? [less ▲]

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See detailAnisotropy and tension-compression asymmetry modeling of the room temperature plastic response of Ti-6A1-4V
Tuninetti, Victor; Gilles, Gaëtan ULg; Pardoen, Thomas et al

in International Journal of Plasticity (2015)

The mechanical behavior of the alloy Ti-6A1-4V is characterized using uniaxial tension, uniaxial compression, simple shear and place strain tests in three orthogonal material directions. The experimental ... [more ▼]

The mechanical behavior of the alloy Ti-6A1-4V is characterized using uniaxial tension, uniaxial compression, simple shear and place strain tests in three orthogonal material directions. The experimental results reveal tension/compression asymmetry, anisotropic yielding and anisotropic strain-hardening. These features are incorporated into an elasto-plastic constitutive law based on the macroscopic orthotropic yield criterion "CPB06" adapted to hexagonal metals. A new identification method for the yield criterion parameters is proposed by inverse modeling of the axial strain field compression specimens in the three orthogonal directions of the material. The sensitivity of different sets of material parameters to the identification method is also analysed and the capacity of the model to accurately predict the forces and displacement field is discussed. A validation of the best set of identified CPB06material parameters is performed by comparing the load-displacement curves in different loading directions for tensile tests on notched round bars with different levels of stress triaxiality and for compression tests on elliptical cross-section specimens, both tests involving multiaxial strain fields and large deformations. [less ▲]

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See detailBuilding on anticipation: dystopia as empowerment
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Current Sociology (2015), 63(2),

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical ... [more ▼]

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical observation of a threatening present that would lead to an apocalyptic future “if nothing was done.” Yet, however inescapable this future may be described, the very existence of such a narrative presupposes that the political community it tries to reach is actually able to do something to thwart it. Oddly enough, a successful dystopia aims at making itself obsolete: once the world it depicts is identified as a possible (or even unavoidable) future, it seems to empower its readers again, restoring what Musil called a ‘sense of possibilities’ that eventually make alternative pathways thinkable. In our contribution, we propose to broaden the range of commonly accepted dystopists (usually fiction writers and novelists like e.g. George Orwell’s 1984) to sociologists like Ulrich Beck. Building on his Risk Society (1986), Beck’s strong diagnosis about the breakdown of First Modernity and the coming of Second Modernity contains a noticeable prophetic and evangelical overtone that aims at “reinventing politics.” We defend the notion that the dystopian posture can be used to characterize both fiction and nonfiction writers such as Orwell and Beck: a common ability, based on the same set of inextricably cognitive and normative patterns, to anticipate the future and eventually empower political communities to engage in further action. [less ▲]

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See detailEffects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis
Preud'Homme, Valérie; Milla, Sylvain; Gillardin, Virginie et al

in Chemosphere (2015), 120(2), 357-364

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of ... [more ▼]

Understanding the impact of pesticides in amphibians is of growing concern to assess the causes of their decline. Among pesticides, endosulfan belongs to one of the potential sources of danger because of its wide use and known effects, particularly neurotoxic, on a variety of organisms. However, the effect of endosulfan was not yet evaluated on amphibians at levels encompassing simultaneously brain neurotransmitters and behavioural endpoints. In this context, tadpoles of the African clawed frog Xenopus laevis were submitted to four treatments during 27 d: one control, one ethanol control, and two low environmental concentrations of endosulfan (0.1 and 1 μg L−1). Endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and GABA levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. The gene coding for the GABA transporter 1 was up-regulated in endosulfan contaminated tadpoles while the expression of other genes coding for the neurotransmitter receptors or for the enzymes involved in their metabolic pathways was not significantly modified by endosulfan exposure. Endosulfan also affected foraging, and locomotion in links with the results of the physiological assays, but no effects were seen on growth. These results show that low environmental concentrations of endosulfan can induce adverse responses in X. laevis tadpoles. At a broader perspective, this suggests that more research using and linking multiple markers should be used to understand the complex mode of action of pollutants. [less ▲]

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See detailNonlinear generalization of Den Hartog׳s equal-peak method
Habib, Giuseppe ULg; Detroux, Thibaut ULg; Viguié, Régis et al

in Mechanical Systems & Signal Processing (2015), 52-53

This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the ... [more ▼]

This study addresses the mitigation of a nonlinear resonance of a mechanical system. In view of the narrow bandwidth of the classical linear tuned vibration absorber, a nonlinear absorber, termed the nonlinear tuned vibration absorber (NLTVA), is introduced in this paper. An unconventional aspect of the NLTVA is that the mathematical form of its restoring force is tailored according to the nonlinear restoring force of the primary system. The NLTVA parameters are then determined using a nonlinear generalization of Den Hartog׳s equal-peak method. The mitigation of the resonant vibrations of a Duffing oscillator is considered to illustrate the proposed developments. [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailEffect of stress path on the miniaturization size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Habraken, Anne ULg et al

in International Journal of Plasticity (2015), 64

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. The objective of this work is to provide new experimental results in order to analyze the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensile tests, large tensile tests and shear tests have been performed on Ni sheets with various grain sizes. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanical softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. From an industrial point of view, it is hence possible to improve the forming of microparts using suitable stress paths. [less ▲]

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See detailEstimation of degree-days for different climatic zones of North-East India
Borah, Pallavi; Singh, Manoj Kumar; Mahapatra, Sadhan

in Sustainable Cities and Society (2015), 14

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