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See detailFibroblast growth factor 23 in acute burn patients: Novel insights from an intact-form assay.
ROUSSEAU, Anne-Françoise ULg; Souberbielle; DELANAYE, Pierre ULg et al

in Burns : Journal of the International Society for Burn Injuries (in press)

INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress ... [more ▼]

INTRODUCTION: Fibroblast growth factor 23 (FGF23) is a key regulator in phosphate and vitamin D metabolism When measured with c-terminal assay, it has been shown to be increased following burn. Progress in understanding FGF23 physiology has emphasized the importance of assessing the intact form of FGF23. METHODS: The present cohort study is a complementary analysis of a previously published work. Patients >18 years, admitted within 24h after injury with burn surface area (BSA) >10% were included. C-terminal (c-term) and intact (i) FGF23 assay were performed at admission and every week during 4 weeks of follow-up. Inflammation and iron status were assessed at the same time points. RESULTS: Twenty patients were initially included and 12 were followed until day 28. The c-term FGF23 tended to gradually increase during the 4 weeks of follow-up while iFGF23 was quite stable into normal ranges. Iron status showed a typical inflammatory profile. C-term FGF23 was significantly positively correlated with c-reactive protein (CRP) and negatively correlated with iron levels. iFGF23 was not correlated with CRP or iron. CONCLUSION: FGF23 status following burn is characterized by a dissociation between c-term FGF23 and iFGF23. The hypothesis of an increased cleavage may be raised. Respective role of inflammation and iron levels in such deregulation need to be specified. Both c-term and intact assays should be performed in further studies aiming to increase knowledge on FGF23 regulation and effects in burn patients. [less ▲]

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See detailLes pôles de compétitivité, des formes organisationnelles aptes à innover en gestion des ressources humaines
Calamel, Ludivine; Defelix, Christian; Pichault, François ULg

in Management International = International Management = Gestión Internacional (in press), 20(4),

Les mises en réseaux se développent de par le monde pour générer de l’innovation collaborative ; en France, elles prennent notamment la forme des « pôles de compétitivité ». La littérature a analysé le ... [more ▼]

Les mises en réseaux se développent de par le monde pour générer de l’innovation collaborative ; en France, elles prennent notamment la forme des « pôles de compétitivité ». La littérature a analysé le fonctionnement de ces réseaux territoriaux d’organisations. Mais alors que leur feuille de route consiste également à produire de l’innovation managériale, via des pratiques de gestion des ressources humaines qui se situent à l’interface d’organisations différentes, l’état des connaissances reste faible sur ce point. Les pôles de compétitivité français représentent-ils une forme organisationnelle innovant également en gestion des ressources humaines ? A l’aune d’une approche contextualiste, mais aussi d’un cadre théorique associant entrepreneuriat institutionnel et acteur-réseau, cet article interroge les modalités de l’innovation managériale dans douze pôles de compétitivité français. Il met en lumière la principale innovation managériale de ces réseaux territoriaux : l’innovation de processus. [less ▲]

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See detailNeeds-Supplies Fit and Behavioral Outcomes: The Mediating Role of Organizational Identification
Travaglianti, Fabrice ULg; Babic, Audrey ULg; Pepermans, Roland et al

in Journal of Management & Organization (in press)

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See detailFrom mechanical to chemical impact of anchoring in seagrasses: the premises of anthropogenic patch generation in Posidonia oceanica meadows
Abadie, Arnaud ULg; Lejeune, Pierre; Pergent, Gérard et al

in Marine Pollution Bulletin (in press)

Intensive anchoring of leisure boats in seagrass meadows leads to mechanical damages. This anthropogenic impact creates bare mat patches that are not easily recolonized by the plant. Several tools are ... [more ▼]

Intensive anchoring of leisure boats in seagrass meadows leads to mechanical damages. This anthropogenic impact creates bare mat patches that are not easily recolonized by the plant. Several tools are used to study human impacts on the structure of seagrass meadows but they are not able to assess the indirect and long term implication of mechanical destruction. We chose to investigate the possible changes in the substrate chemistry given contrasted boat impacts. Our observations show that hydrogen sulfide concentrations remain high at 15 and 20 m depth (42.6 µM and 18.8 µM) several months after the highest period of anchoring during the summer. Moreover, our multidisciplinary study reveals that anchoring impacts of large boats at 15 and 20 m depth can potentially change the seascape structure. By taking into account both structural and chemical assessments, different managing strategies must be applied for coastal areas under anthropogenic pressures. [less ▲]

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See detailThe “Tuchlein” Colours in the Strasbourg Family Text: Recipes for Anthocyanin Pigments
Neven, Sylvie ULg; Sanyova, Jana

in Dyes in History and Archaeology (in press)

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See detailSur Capitalisme, désir et servitude. Lettre à Frédéric Lordon
Pieron, Julien ULg

in Dissensus (in press), 6(printemps 2014),

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See detailMemory consolidation in children with Specific Language Impairment: Delayed gains and susceptibility to interference in implicit sequence learning
Desmottes, Lise ULg; Maillart, Christelle ULg; Meulemans, Thierry ULg

in Journal of Clinical and Experimental Neuropsychology (in press)

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language ... [more ▼]

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language impairment (SLI). Two aspects of memory consolidation in implicit sequence learning were examined: the evolution of post-training gains in sequence knowledge (Experiment 1) and the susceptibility to interference (Experiment 2). Method and Results: In the first experiment, 18 children with SLI and 17 control children matched for sex, age, and nonverbal intelligence completed a serial reaction-time (SRT) task and were tested 24 hours and 1 week after practicing. The two groups of children attained an equal level of sequence knowledge in the training session, but the children with SLI lacked the consolidation gains displayed by the control children in the two post-training sessions. Working with a new group of children, 17 with SLI and 17 control peers, Experiment 2 examined resistance to interference by introducing a second sequence 15 minutes after the first training session. Similar results were obtained for the performance of both groups in the training session. However, although the performance of the control group improved in the post-training sessions, the performance of the SLI group deteriorated significantly during the consolidation phase due to the interfering sequence. Conclusion: These findings suggest that the consolidation phase of sequence learning is impaired in children with SLI. [less ▲]

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See detailRéduire l’altérité au travers des processus de traduction et de représentation
Leclercq, Bruno ULg; Smette, Bernard ULg

in Doctorales. Revue LLA-SHS de Montpellier (in press)

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity ... [more ▼]

WVO Quine questions the « myth » of an ideal realm of shared meanings which every national language would express in its own way. Against the hope of transparent translations, he insists on the necessity for building equivalences from one language to another through a strategy of reducing the differences in rationality among nations as much as possible. According to Quine, otherness is not insuperable impediment to meeting/encounter and mutual understanding ; by throwing our conceptual schemes on the other communities’ uses/practices – which of course involves some symbolic violence – gaps can always been narrowed. Similarly E. Laclau questions the traditional conception of political representation, which is seen as the transparent process of transmitting someone’s will or interests on another level. For this ideal conception of representation, Laclau substitutes a pragmatic conception which takes in account the irreducible gap between the actors as well as the constitutive opacity of the process of representation : the subject’s will is constituted within the process of representation and through the representative’s productive role. In order to be transposed at the decision-making level, the subject’s interests must be translated by the representative as well as be negotiated with the other represented interests. This implies that the initial will undergoes some identity transformations. [less ▲]

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See detailLevallois et Gravettien
Otte, Marcel ULg; Noiret, Pierre ULg

in Praehistoria (in press)

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein ... [more ▼]

Par opposition à ceux de l’Aurignacien, les ensembles lithiques gravettiens procèdent selon une méthode rappelant le Levallois quant à la préparation des supports. Mais les variations observables au sein du Gravettien touchent autant les processus de symbolisation dans l’art et les sépultures. Elles affectent différents substrats eurasiatiques, plutôt septentrionaux, comme mis en réserve dès les Néandertaliens. [less ▲]

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See detailProjections photographiques et cinéma des premiers temps : La houillère de Gustave Marissiaux et les origines du cinéma minier
Mélon, Marc-Emmanuel ULg

in Intermédialités : Histoire et Théorie des Arts, des Lettres et des Techniques = Intermediality: History and Theory of the Arts, Literature and Technologies (in press)

Les spectacles de projection conçus par Gustave Marissiaux entre 1903 et 1926, en particulier le vaste documentaire intitulé "La houillère" (1905) est ici inscrit dans une histoire sociale des images ... [more ▼]

Les spectacles de projection conçus par Gustave Marissiaux entre 1903 et 1926, en particulier le vaste documentaire intitulé "La houillère" (1905) est ici inscrit dans une histoire sociale des images projetées et mis en rapport avec le cinéma minier des premiers temps [less ▲]

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See detailContribution à un lexique épigraphique: "deltographéma"
Famerie, Etienne ULg

in Zeitschrift für Papyrologie und Epigraphik (in press)

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See detailCultural Marxism : A Survey
Jamin, Jérôme ULg

in Religion Compass (in press)

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See detailOn the finiteness of the weighted likelihood estimator of ability
Magis, David ULg; Verhelst, Norman

in Psychometrika (in press)

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is ... [more ▼]

The purpose of this note is to focus on the finiteness of the weighted likelihood estimator (WLE) of ability in the context of dichotomous and polytomous item response theory (IRT) models. It is established that the WLE always returns finite ability estimates. This general result is valid for dichotomous (one-, two-, three- and four-parameter logistic) IRT models, the class of polytomous difference models and divide-by-total models, independently of the number of items, the item parameters and the response patterns. Further implications of this result are outlined. [less ▲]

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See detailStructure – Oxygen Reduction Reaction Activity Relation-ships in Porous Hollow PtNi/C Nanoparticles
Asset, Tristan ULg; Chattot, Raphaël; Nelayah, Jaysen et al

in ChemElectroChem (in press)

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See detailMeanings and practices of learning from incidents: a social constructivist perspective of incident reporting systems
Rossignol, Nicolas ULg; Hommels, Anique

in Technology Analysis & Strategic Management (in press)

Incident reporting systems (IRSs) are used in many organisations as tools that promote safety by allowing to collectively learn from incidents. In this paper, we propose a social constructivist approach ... [more ▼]

Incident reporting systems (IRSs) are used in many organisations as tools that promote safety by allowing to collectively learn from incidents. In this paper, we propose a social constructivist approach to learning from incidents, in which the focus is not purely on safety, but on the technology of incident reporting itself. We employ Wiebe Bijker’s work on the Social Construction of Technology to open up the analysis of a specific IRS in use at the Belgian Nuclear Research Center. For this purpose, we carried out 28 interviews with key local actors and collected documents and observation notes. Such social constructivist perspective provides detailed insight into the practices of reporting and the meanings of learning from incidents. Our research shows that various actors within the organisation frame the IRS differently. These framings each have their own implications for the vulnerability of the organisation. [less ▲]

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See detailSur les pas des hommes qui ont vu l’ours. La conservation de la faune sauvage, un travail réel.
Denayer, Dorothée ULg; Mougenot, Catherine ULg; Collard, Damien

in Natures Sciences Sociétés (in press)

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See detailOutplacement adequacy and benefits: The mediating role of overall justice.
Marzucco, Laurence ULg; Hansez, Isabelle ULg

in Journal of Employment Counseling (in press)

Despite a rapid growth and an ongoing need for outplacement services, little is yet known about the perceived adequacy and benefits of these services for redundant employees using them. We surveyed 360 ... [more ▼]

Despite a rapid growth and an ongoing need for outplacement services, little is yet known about the perceived adequacy and benefits of these services for redundant employees using them. We surveyed 360 Belgian redundant employees (i.e., clients) using outplacement services provided by a public employment agency. The results indicate that an outplacement experience perceived as adequate for clients fosters their overall impressions of justice towards the dismissing organization; this leads in turn to benefits for them: reduction of negative emotions, enhancement of their perceived well-being, future perspectives, and job-seeking activities - confirming the mediating role of overall justice. [less ▲]

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See detailAn item analysis of the French version of the Test for Reception of Grammar among children and adolescents with Down syndrome or intellectual disability of undifferentiated etiology
Facon, Bruno; Magis, David ULg

in Journal of Speech, Language, and Hearing research (in press)

Purpose: An item analysis of Bishop’s (1983) Test for Reception of Grammar (TROG) in its French version (F-TROG, Lecocq, 1996) was conducted to determine whether the difficulty of items is similar for ... [more ▼]

Purpose: An item analysis of Bishop’s (1983) Test for Reception of Grammar (TROG) in its French version (F-TROG, Lecocq, 1996) was conducted to determine whether the difficulty of items is similar for participants with or without intellectual disability (ID). Method: In Study 1, responses to the 92 F-TROG items by 55 participants with Down syndrome (DS), 55 with ID of undifferentiated etiology (UND) and 55 typical children (TYP) matched on their F-TROG total score were compared using the transformed item difficulties method, a statistical approach designed to detect differential item functioning (DIF) between groups. In Study 2, an additional comparison involving 526 TYP participants and 526 participants with UND was conducted to increase the statistical power of the analysis. Results: The difficulty of items was highly similar whatever the sample size or clinical status of participants. Fewer than 3.5 % of the items were flagged as showing DIF. Conclusions: Tests such as the TROG can be used with confidence in clinical practice as well as in research studies comparing participants with or without ID. Methods designed for investigating potential internal test bias – such as done here – should be more regularly employed in the developmental disability field to affirm the absence of DIF. [less ▲]

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See detailA Quantitative Doignon-Bell-Scarf theorem
Aliev, Iskander; Bassett, Robert; De Loera, Jesus et al

in Combinatorica (in press)

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative ... [more ▼]

The famous Doignon-Bell-Scarf theorem is a Helly-type result about the existence of integer solutions to systems of linear inequalities. The purpose of this paper is to present the following quantitative generalization: Given an integer k, we prove that there exists a constant c(n,k), depending only on the dimension n and on the number k, such that if a bounded polyhedron {x in R^n : Ax <= b} contains exactly k integer points, then there exists a subset of the rows, of cardinality no more than c(n,k), defining a polyhedron that contains exactly the same k integer points. In this case c(n,0)=2^n as in the original case of Doignon-Bell-Scarf for infeasible systems of inequalities. We work on both upper and lower bounds for the constant c(n,k) and discuss some consequences, including a Clarkson-style algorithm to find the l-th best solution of an integer program with respect to the ordering induced by the objective function. [less ▲]

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See detailOrigine et histoire de la folie : un nouveau Foucault, un nouveau fou
Englebert, Jérôme ULg

in Evolution Psychiatrique (in press)

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See detailL'espace transitionnel winnicotien et l'_Urraum_ kantien
Seba, Jean-Renaud ULg

in Revista Natureza Humana (in press)

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See detailHow can a steel structure survive to impact loading? Numerical and analytical investigations
Demonceau, Jean-François ULg; Comeliau, Ludivine; Hoang, Van Long ULg et al

in Open Civil Engineering Journal (The) (in press)

Recent events such as natural catastrophes or terrorism attacks have highlighted the necessity to ensure the structural integrity of buildings under exceptional events. For more than 10 years, the ... [more ▼]

Recent events such as natural catastrophes or terrorism attacks have highlighted the necessity to ensure the structural integrity of buildings under exceptional events. For more than 10 years, the University of Liege is strongly involved in researches investigating the response of structures further to such exceptional events ([1] and [2]). The present paper gives a global overview on recent or ongoing developments performed at the University of Liege in the field of robustness of steel building structures subjected to impact loading leading to the loss of a column. The conducted studies are founded on a combination of experimental, numerical and analytical approaches with the final aim to propose simplified procedures useful for practitioners and allowing ensuring an appropriate level of robustness to structures for the considered scenario [less ▲]

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See detailMontage et résistance du réel chez S. Kracauer: Photographie, cinéma, texte.
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in Bulletin d'Analyse Phénoménologique (in press)

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage » ... [more ▼]

Partant de quelques textes dans lesquels S. Kracauer traite du rapport entre montage et réel, cet article tente de préciser et de problématiser l’ambivalence de Kracauer à l’égard de l’outil « montage », notamment dans le champ cinématographique, en ouvrant la réflexion par cette double question : comment définir un « mauvais usage » du montage et, à l’opposé, comment peuvent se mettre en place les conditions d’un « bon usage » du montage selon Kracauer ? Pour y répondre, les auteurs identifient d'abord, dans l’œuvre de Kracauer, les éléments explicites et implicites (montage textuel) qui permettent de saisir au plus près ce que serait, selon le philosophe et sociologue, le principe de réalité. Ensuite, une œuvre photographique, contemporaine des quelques textes évoqués, Menschen des 20. Jahrhunderts d’August Sander, permet de mieux circonscrire les possibles concrétisations de cette pensée en la mettant à l’épreuve d’une réalisation en images et en montage. [less ▲]

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See detailQuadratic reformulations of nonlinear binary optimization problems
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Mathematical Programming (in press)

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these ... [more ▼]

Very large nonlinear unconstrained binary optimization problems arise in a broad array of applications. Several exact or heuristic techniques have proved quite successful for solving many of these problems when the objective function is a quadratic polynomial. However, no similarly efficient methods are available for the higher degree case. Since high degree objectives are becoming increasingly important in certain application areas, such as computer vision, various techniques have been recently developed to reduce the general case to the quadratic one, at the cost of increasing the number of variables. In this paper we initiate a systematic study of these quadratization approaches. We provide tight lower and upper bounds on the number of auxiliary variables needed in the worst-case for general objective functions, for bounded-degree functions, and for a restricted class of quadratizations. Our upper bounds are constructive, thus yielding new quadratization procedures. Finally, we completely characterize all ``minimal'' quadratizations of negative monomials. [less ▲]

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See detailCritique du capitalisme néolibéral et travail rhétorique chez Frédéric Lordon : un discours d’affectation.
Provenzano, François ULg; Janvier, Antoine ULg

in Dissensus (in press)

Les ouvrages de Frédéric Lordon ont offert ces dernières années un éclairage nouveau des mécanismes de la finance et du capitalisme en régime néolibéral, en vertu de la place centrale qu’ils accordent aux ... [more ▼]

Les ouvrages de Frédéric Lordon ont offert ces dernières années un éclairage nouveau des mécanismes de la finance et du capitalisme en régime néolibéral, en vertu de la place centrale qu’ils accordent aux affects. Il est frappant que cette entreprise – qui est triple: analyse de la finance, analyse du capitalisme, analyse de la domination – soit doublée d’une attention portée au discours même qui la développe. On peut repérer une telle attention dans la pluralité des genres de discours qu’investit Frédéric Lordon : ouvrages « savants » ou « universitaires », mais aussi courts essais engagés aux éditions Raisons d’agir, articles de presse dans Le Monde Diplomatique notamment, tenue du blog « La pompe à phynance » sur le site du même journal, et même pièce de théâtre récemment adaptée au cinéma, D’un retournement l’autre. Comédie sérieuse sur la crise financière. En quatre actes, et en alexandrins . Diversité de genre entre les différents types de textes, donc. Diversité interne à chacun de ces textes, aussi : le lecteur de Frédéric Lordon se trouve toujours à cheval sur plusieurs codes rhétoriques dont joue l’auteur dans un même ouvrage. On pourrait bien sûr tenir cette double diversité pour la simple conséquence du talent d’écriture de Lordon, ou d’un plaisir pris par l’auteur à jouer du langage et des ethos qu’il construit. Le présent article propose au contraire de considérer cette diversité comme le résultat d’un véritable travail sur les modalités rhétoriques du discours critique sur le capitalisme financiarisé, qu’il faut articuler aux principaux postulats de sa théorie sociale. L’hypothèse défendue sera, précisément, de considérer qu’il y a une construction rhétorique qui participe de l’entreprise critique et, du même coup, qui s’inscrit comme un geste politique dans une « société des affects ». [less ▲]

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See detailLa collaboration entre architectes et plasticiens à Liège dans les années 1930.
Charlier, Sébastien ULg

in In Situ, revue des patrimoines (in press), 26

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales ... [more ▼]

En 1928, des étudiants de l’Académie des Beaux-Arts de Liège fondent la revue d’architecture et d’urbanisme L’Équerre. S’inscrivant bien que tardivement dans la continuité des avant-gardes internationales, le mensuel revendique une vision transversale de l’architecture où la réflexion plastique occupe une place centrale. Dès le départ, elle s’associe à Anthologie, revue imprégnée des théories futuristes et qui diffuse les artistes de l’avant-garde locale. D’abord par le biais de l’édition et des expositions, plasticiens et architectes travaillent ensuite ensemble dans le cadre de projets ambitieux financés par les pouvoirs publics. Cette contribution revient aux racines de cette collaboration en définissant les liens théoriques ou personnels unissant les deux revues. En se concentrant sur les infrastructures publiques, elle comment les artistes et les architectes ont répondu ensemble aux exigences concrètes de la commande en les replaçant dans le contexte social, politique et économique d’une ville belge de seconde importance à la veille de la Seconde Guerre mondiale. [less ▲]

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See detailThe Poetics of (In)visibility: A Stylistic Analysis of Caryl Phillips's Foreigners: Three English Lives
Tunca, Daria ULg

in Ariel : A Review of International English Literature (in press)

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See detailDetermination of iohexol and iothalamate in serum and urine by capillary electrophoresis.
Van Houcke, Sofie K.; Seaux, Liesbeth; Cavalier, Etienne ULg et al

in Electrophoresis (in press)

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or ... [more ▼]

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or radioactive compounds. However, HPLC is a time-consuming and labour-intensive method. The aim of this study was to develop an assay for iohexol and iothalamate using capillary electrophoresis (CE). Iohexol and iothalamate were directly analysed by CE in serum and urine, using photometric detection (246 nm). Serum peak height was proportional to iohexol and iothalamate concentrations. Detection limits for iohexol and iothalamate were 10 mg/L and 5 mg/L. Limits of quantification were 13.0 mg/L and 15.0 mg/L. Within-run CVs were 4.9% and 6.5%; between-run CVs 3.1-9.9% and 3.8-13.7%. A good correlation was observed between CE and HPLC: y = 1.1703 x + 5.017 (iohexol) and y = 0.7807 x + 11.01 (iothalamate) [y = concentration obtained by CE (mg/L), x = concentration obtained by HPLC (mg/L)]. In addition, CE allowed to determine urinary iohexol concentration. Although the detection limit for CE was higher than for HPLC, CE can still be used for eGFR determination. Advantages of this high throughput method are the absence of sample pretreatment and a minimal sample volume requirement. This article is protected by copyright. All rights reserved. [less ▲]

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See detailEpistémologie de la théorie du complot
Jamin, Jérôme ULg

in Cahiers de l'Éducation Permanente (Les) (in press)

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See detailThe colonisation history of British water vole (Arvicola amphibius [L., 1758]): origins and development of the Celtic Fringe
Brace, Selina; Ruddy, Mark; Miller, Rebecca ULg et al

in Proceedings of the Royal Society B : Biological Sciences (in press)

The terminal Pleistocene and Early Holocene, a period from 15 000 to 18 000 Before Present (BP), was critical in establishing the current Holarctic fauna, with temperate-climate species largely replacing ... [more ▼]

The terminal Pleistocene and Early Holocene, a period from 15 000 to 18 000 Before Present (BP), was critical in establishing the current Holarctic fauna, with temperate-climate species largely replacing cold-adapted ones at midlatitudes. However, the timing and nature of this process remain unclear for many taxa, a point that impacts on current and future management strategies. Here, we use an ancient DNA dataset to test more directly postglacial histories of the water vole (Arvicola amphibius, formerly A. terrestris), a species that is both a conservation priority and a pest in different parts of its range. We specifically examine colonization of Britain, where a complex genetic structure can be observed today. Although we focus on population history at the limits of the species’ range, the inclusion of additional European samples allows insights into European postglacial colonization events and provides a molecular perspective on water vole taxonomy. [less ▲]

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See detailLarge deviation spectra based on wavelet leaders
Bastin, Françoise ULg; Esser, Céline ULg; Jaffard, Stéphane ULg

in Revista Matemática Iberoamericana (in press)

We introduce a new multifractal formalism, based on distributions of wavelet leaders, which allows to detect non-concave and decreasing multifractal spectra, and we investigate the properties of the ... [more ▼]

We introduce a new multifractal formalism, based on distributions of wavelet leaders, which allows to detect non-concave and decreasing multifractal spectra, and we investigate the properties of the associated function spaces. [less ▲]

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See detailA Theory of Soft Capture
Agrell, Per; Gautier, Axel ULg

in Scandinavian Journal of Economics (in press)

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to ... [more ▼]

n this paper, wee propose a model for regulatory capture that is based on information transmission and asymmetric information. In a three-tier model, a regulator is charged by a political principal to provide a signal for the type of a regulated firm. Only the firm can observe his type and the production of a correlated signal with a given accuracy is costly for the regulator. The firm can costlessly provide an alternative signal of lower accuracy that is presented to the regulator. In a self-enforcing equilibrium, the regulator transmits the firm-produced signal, internalizes its own savings in information cost and the firm enjoys higher information rents. The main feature of soft capture is that it is not based on a reciprocity of favors but on a congruence of interests between the firm and the regulator. [less ▲]

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See detailUse of Tyrosine Kinase Inhibitors to Prevent Relapse After Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Position Statement of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Giebel, S.; Czyz, A.; Ottmann, O. et al

in Cancer (in press)

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) to first-line therapy has improved overall outcomes; however, a significant proportion of patients still relapse after alloHSCT. Posttransplant TKI maintenance was demonstrated to reduce the risk of relapse in a large retrospective study and, therefore, should be considered a valuable option. This consensus paper, written on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, presents an overview of clinical studies on the use of TKIs after alloHSCT and proposes practical recommendations regarding the choice of TKI, treatment timing, and dosage. It is hoped that these recommendations will become the state of art in this field and, more importantly, lead to a reduction of Ph-positive ALL relapse after alloHSCT. [less ▲]

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See detailWhom do architects design for in design competitions? A case study
Verhulst, Lore; Elsen, Catherine ULg; Heylighen, Ann

in Journal of Design Research (in press)

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See detailA combined transmission spectrum of the Earth-sized exoplanets TRAPPIST-1 b and c
de Wit, Julien; Wakeford, Hannah R.; Gillon, Michaël ULg et al

in Nature (in press)

Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1. The nature of these planets has yet to be determined, since their masses ... [more ▼]

Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1. The nature of these planets has yet to be determined, since their masses remain unmeasured and no observational constraint is available for the planetary population surrounding ultracool dwarfs, of which the TRAPPIST-1 planets are the first transiting example. Theoretical predictions span the entire atmospheric range from depleted to extended hydrogen-dominated atmospheres. Here, we report a space-based measurement of the combined transmission spectrum of the two inner planets made possible by a favorable alignment resulting in their simultaneous transits on 04 May 2016. The lack of features in the combined spectrum rules out cloud-free hydrogen-dominated atmospheres for each planet at 10-$\sigma$ levels; TRAPPIST-1 b and c are hence unlikely to harbor an extended gas envelope as they lie in a region of parameter space where high-altitude cloud/haze formation is not expected to be significant for hydrogen-dominated atmospheres. Many denser atmospheres remain consistent with the featureless transmission spectrum---from a cloud-free water vapour atmosphere to a Venus-like atmosphere. [less ▲]

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See detailInfectivity of a recombinant murine norovirus (RecMNV) in Balb/cByJ mice
Mathijs, Elisabeth; de Oliveira-Filho, Edmilson; Dal Pozzo, Fabiana ULg et al

in Veterinary Microbiology (in press)

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See detailCompte rendu de G. TOUSSAINT, Kreuz und Knochen. Reliquien zur Zeit der Kreuzzüge, Berlin, 2011.
George, Philippe ULg

in Cahiers de Civilisation Médiévale (in press)

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See detailNew insight on Carboniferous (Viséan) brachiopods from eastern Tafilalt (Morocco)
Mottequin, Bernard; Denayer, Julien ULg; Herbig, Hans-Georg et al

in Geological Journal (in press)

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See detailSurvivances et métamorphoses. Les gemmes isiaques remployées au Moyen Âge et leur interprétation
Veymiers, Richard ULg

in Anabases : Traditions et Réception de l'Antiquité (in press)

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See detailSérialités tintamarresques. Du faux-feuilleton au dictionnaire
Saint-Amand, Denis ULg

in Belphégor : Littérature Populaire et Culture Médiatique (in press)

Parmi les journaux comiques les plus en vue du XIXe siècle, l’hebdomadaire Tintamarre occupe une place de choix. Ses fers de lance, Jean-Louis Commerson et Eugène Vachette s’adjoignent les services ... [more ▼]

Parmi les journaux comiques les plus en vue du XIXe siècle, l’hebdomadaire Tintamarre occupe une place de choix. Ses fers de lance, Jean-Louis Commerson et Eugène Vachette s’adjoignent les services imaginaires de l’écrivain de papier Joseph Citrouillard, qui va rapidement se révéler l’un des contributeurs les plus fidèles du Tintamarre et le sujet de nombreux articles. C’est, dès lors, une double logique sérielle qui se développe autour de Citrouillard, à la fois canular auctorial et antihéros populaire. Cet article interroge les implications et les effets de cette double casquette fantaisiste en ce qui concerne la logique interne du journal et le développement en son sein d’une poétique parodique spécifique, mais également en matière d’institutionnalisation d’une forme de mystification littéraire. [less ▲]

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See detailSpinoza contre Spinoza: l'antihumanisme de Lordon, un althussérisme?
Mancuso, Eva ULg

in Dissensus (in press), 6

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See detailTeletê peut-elle être déesse ? Note épigraphique (SEG 50, 168)
Pirenne-Delforge, Vinciane ULg

in Mètis : Revue d'Anthropologie du Monde Grec Ancien : Philologie, Histoire, Archéologie (in press)

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See detailFungal biofilm reactor improves the productivity of hydrophobin HFBII
Khalesi, Mohammadreza; Zune, Quentin ULg; Telek, Samuel ULg et al

in Biochemical Engineering Journal (in press)

Production and purification of hydrophobin HFBII has recently been the subject of intensive research, but the yield of production needs to be further improved for a generic use of this molecule at ... [more ▼]

Production and purification of hydrophobin HFBII has recently been the subject of intensive research, but the yield of production needs to be further improved for a generic use of this molecule at industrial scale. In a first step, the influence of different carbon sources on the growth of Trichoderma reesei and the production of HFBII was investigated. The optimum productivity was obtained by using 40 g/L lactose. Carbon starvation and excretion of extracellular enzyme were determined as two main conditions for the production of HFBII. In the second phase, and according to the physiological mechanisms observed during the screening phase, a bioreactor set up has been designed and two modes of cultures have been investigated, i.e. the classical submerged fermentation and a fungal biofilm reactor. In this last set-up, the broth is continuously recirculated on a metal packing exhibiting a high specific surface. In this case, the fungal biomass was mainly attached to the metal packing, leading to a simplification of downstream processing scheme. More importantly, the HFBII concentration increased up to 48.6 ± 6.2 mg/L which was 1.8 times higher in this reactor configuration and faster than the submerged culture. X-ray tomography analysis shows that the biofilm overgrowth occurs when successive cultures are performed on the same packing. However, this phenomenon has no significant influence on the yield of HFBII, suggesting that this process could be operated in continuous mode. Protein hydrolysis during stationary phase was observed by MALDI-TOF analysis according to the removal of the last amino acid from the structure of HFBII after 48 h from the beginning of fermentation in biofilm reactor. Hopefully this modification does not lead to alternation of the main physicochemical properties of HFBII. [less ▲]

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See detailOccurrence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary, Argentina, and their mid-distance movements along the Northeast Patagonian coast
Failla, Mauricio; Seijas, Veronica; Vermeulen, Els ULg

in Latin American Journal of Aquatic Mammals (in press)

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data ... [more ▼]

A systematic study on the presence of bottlenose dolphins (Tursiops truncatus) in the Río Negro Estuary (RNE), Patagonia Argentina, was carried out between the months March – July from 2008 to 2011. Data on the dolphin’s activity patterns were gathered via an Ad Libitum focal group sampling mode accompanying dorsal fin images taken for identification and re-identification of individuals. A total effort of 188 h resulted in 58 h of positive observation of 124 dolphin groups (sightings per unit effort (SPUE) = 0.66 groups/h). Data analysis showed two main activity states for the observed groups, travelling (65%) and foraging (26%). The remaining 9% of the groups were involved in other activity states. The photo-identification effort, which started opportunistically in 2006, resulted in a catalogue of 21 individual dolphins, with a total mean re-identification rate of 9 days (max = 24 days). When comparing these pictures to the existing catalogue of Bahía San Antonio (approximately 200 km west from the study area) dorsal fins of 20 individuals could be positively matched and most (n = 17) could be subsequently re-identified in both areas, indicating their long distance movements along the North Patagonian coast during the austral autumn months. This season coincides with the lowest amount of feeding activity observed in Bahía San Antonio. This study suggests that bottlenose dolphins enter RNE, mainly during autumn, to forage. It appears that the search for food resources may be the trigger for their movement patterns along the North Patagonian coast during this season, at least for certain individuals. More research is needed to accurately confirm this hypothesis. [less ▲]

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See detailL'adolescent contemporain, la dette de vie et la question du don: apport de l'approche contextuelle
Haxhe, Stéphanie ULg; de Saint Georges, Marie-Christine; Michard, Pierre et al

in Adolescence (in press)

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît ... [more ▼]

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît alors comme une quête en tension entre une nécessaire appropriation de lui-même et des dons discrets à ses parents. Si ces dons ne sont pas reçus et échouent à introduire parents et adolescent à une nouvelle position relationnelle, le risque d’un épuisement de l’adolescent est à prendre en considération. [less ▲]

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See detailLa question du diagnostic en psychiatrie infanto-juvénile
de Becker, Emmanuel; François, Anne; Kinoo, Philippe et al

in Psychiatrie de l'Enfant (La) (in press)

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi ... [more ▼]

Dans le vaste champ de l’aide et des soins à l’égard de l’enfant et de l’adolescent, les questions liées au diagnostic transcendent souvent les aspects de prises en charge et de liens thérapeutiques ainsi que les multiples échanges entre professionnels concernés. Le diagnostic pédopsychiatrique est un processus dynamique, modifiable et momentané, les organisations pathologiques étant pour la plupart en transformation permanente. De manière spécifique et en fonction du processus développemental, la thématique du diagnostic en pédopsychiatrie renvoie plus à la question du risque évolutif qu’à la question d’un état pathologique en soi. Les aspects de la continuité des troubles mentaux de l’enfance à l’âge adulte représentent en effet un véritable enjeu développemental. Deux points de vue s’opposent dans la littérature. Le premier, en lien avec un prédéterminisme, estime que les trajectoires sont toutes tracées, l’incertitude reposant dans le diagnostic ; concrètement, il s’agit de repérer de manière précoce des individus à risque parce qu’ils sont porteurs d’un trouble qu’il faut traiter. Le second point de vue considère que les trajectoires ne sont pas déterminées mais sont en réécriture permanente ; ici, le risque ne se situe plus au niveau du diagnostic mais du pronostic, dans un souci de prévention et non de prédiction. L’article propose les réflexions de quatre cliniciens psychiatres infanto-juvéniles sur cette thématique, à la lumière de leur pratique et de leurs échanges. [less ▲]

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See detailIs it possible to improve communication around radiotherapy delivery: A randomized study to assess the efficacy of team training?
Liénard, Aurore; Delevallez, France; Razavi, Darius et al

in Radiotherapy & Oncology (in press)

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See detailSpecific expression and function of inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) in wild type and knock-out mice
Scoumanne, Ariane; Molina Ortiz, Patricia ULg; Monteyne, Daniel et al

in Advances in Biological Regulation (in press)

Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5 ... [more ▼]

Inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) is the last identified member of the inositol 1,4,5-trisphosphate 3-kinases family which phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate. Although expression and function of the two other family members ITPKA and ITPKB are rather well characterized, similar information is lacking for ITPKC. Here, we first defined the expression of Itpkc mRNA and protein in mouse tissues and cells using in situ hybridization and new antibodies. Surprisingly, we found that cells positive for ITPKC in the studied tissues express either a multicilium (tracheal and bronchial epithelia, brain ependymal cells), microvilli forming a brush border (small and large intestine, and kidney proximal tubule cells) or a flagellum (spermatozoa), suggesting a role for ITPKC either in the development or the function of these specialized cellular structures. Given this surprising expression, we then analyzed ITPKC function in multiciliated tracheal epithelial cells and sperm cells using our Itpkc knock-out mouse model. Unfortunately, no significant difference was observed between control and mutant mice for any of the parameters tested, leaving the exact in vivo function of this third Ins(1,4,5)P3 3-kinase still open. [less ▲]

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See detailLes associations des enfants et jeunes travailleurs du Burkina Faso comme espace d’expression de la capacité d’action des enfants ?
Wouango, Joséphine ULg

in Enfances Familles Générations (in press)

Les Associations des Enfants et Jeunes Travailleurs du Burkina Faso (AEJT/BF) sont une représentation nationale du Mouvement Africain des Enfants et Jeunes Travailleurs (MAEJT), créé à la fin des années ... [more ▼]

Les Associations des Enfants et Jeunes Travailleurs du Burkina Faso (AEJT/BF) sont une représentation nationale du Mouvement Africain des Enfants et Jeunes Travailleurs (MAEJT), créé à la fin des années 1980. Le mouvement est fondé sur deux grands principes : les douze droits prioritaires des enfants et jeunes travailleurs et le principe du « protagonisme » (l’enfant travailleur comme acteur capable) . Ce chapitre présente et analyse le fonctionnement de ce mouvement au Burkina Faso, les changements qu’il a contribué à apporter à la question sociale du travail des enfants et les résultats de la mise en application des principes annoncés. S’appuyant sur une enquête ethnographique menée en son sein, le texte offre des données inédites sur les réalités d’un acteur collectif qui, en utilisant à son avantage la rhétorique de la « participation » des enfants (art.12, Convention des droits de l’enfant), a réussi à s’insérer dans l’arène nationale de la protection de l’enfance. Toutefois, la question de la place et du rôle des enfants ainsi que celle du “vieillissement” des membres sont quelques-uns des défis auxquels la section burkinabè du mouvement doit faire face. [less ▲]

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See detailThe right dorsal premotor mosaic: organization, functions, and connectivity
Genon, Sarah ULg; Li, Hai; Fan, Lingzhong et al

in Cerebral Cortex (in press)

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a ... [more ▼]

The right dorsal premotor cortex (PMd) of humans has been reported to be involved in a broad range of motor and cognitive functions. We explored the basis of this behavioral heterogeneity by performing a connectivity-based parcellation using meta-analytic approach applied to PMd coactivations. We compared our CBP results to parcellations obtained through resting-state functional connectivity and probabilistic diffusion tractography,. Functional connectivity profiles and behavioral decoding of the resulting PMd subregions allowed characterizing their respective behavior profile. These procedures divided the right PMd into five distinct subregions that formed a cognitive-motor gradient along a rostro-caudal axis. In particular, we found (i) a rostral subregion functionally connected with prefrontal cortex, which likely supports high-level cognitive processes, such as working memory (ii) a central subregion showing a mixed behavioral profile and functional connectivity to parietal regions of the dorsal attention network, and (iii) a caudal subregion closely integrated with the motor system. Additionally, we found (iv) a dorsal subregion, preferentially related to hand movements and connected to both cognitive and motor regions, and (v) a ventral subregion, whose functional profile fits the concept of an eye-movement related field. In conclusion, right PMd may be considered as a functional mosaic formed by five subregions. [less ▲]

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See detail1 Conjoint influence of mind-wandering and sleepiness on task performance
Stawarczyk, David ULg; D'Argembeau, Arnaud ULg

in Journal of Experimental Psychology. Human Perception & Performance (in press)

Recent research suggests that sleepiness and mind-wandering—the experience of thoughts that are both stimulus-independent and task-unrelated—frequently co-occur and are both associated with poorer ... [more ▼]

Recent research suggests that sleepiness and mind-wandering—the experience of thoughts that are both stimulus-independent and task-unrelated—frequently co-occur and are both associated with poorer cognitive functioning. Whether these two phenomena have distinguishable effects on task performance remains unknown, however. To investigate this question, we employed the online experience sampling of mind-wandering episodes and subjective sleepiness during a laboratory task (the Sustained Attention to Response Task; SART), and also assessed mind-wandering frequency and sleep-related disturbances in daily life using self-report questionnaires. The results revealed that the tendency to experience mind-wandering episodes during the SART and daily life was associated with higher levels of daytime sleepiness and sleep-related disturbances. Importantly, however, mind-wandering and sleepiness were independent predictors of SART performance at both the within- and between-individuals levels. These findings demonstrate that, although mind-wandering and sleepiness frequently co-occur, these two phenomena have distinguishable and additive effects on task performance. [less ▲]

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See detailIs the sword moss (Bryoxiphium) a preglacial Tertiary relict?
Patino, J.; Goffinet, B.; Sim-Sim, M.A. et al

in Molecular Phylogenetics & Evolution (in press)

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See detailULTRASONOGRAPHIC FINDINGS IN 13 HORSES WITH LYMPHOMA
Janvier, Valentin; Evrard, Laurence ULg; Cerri, Simona ULg et al

in Veterinary Radiology & Ultrasound (in press)

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See detailImpacts of ikaite export from sea ice to the underlying seawater in a sea ice-seawater mesocosm
Geilfus, N.-X.; Galley, R. J.; Else, B. G. T. et al

in Cryosphere (The) (in press)

Ikaite precipitation within sea ice could act as a significant sink for atmospheric CO2. However, the fate of these ikaite crystals is still poorly understood. We quantify temporal inorganic carbon ... [more ▼]

Ikaite precipitation within sea ice could act as a significant sink for atmospheric CO2. However, the fate of these ikaite crystals is still poorly understood. We quantify temporal inorganic carbon dynamics from initial sea ice formation from open water to its melt during a month-long experiment in a sea ice-seawater mesocosm pool. Within sea ice, ikaite precipitation and CO2 exchange with the atmosphere were the main processes affecting inorganic carbon dynamics, while the dissolution of ikaite was the main process affecting inorganic carbon dynamics in the underlying seawater. Based on the total alkalinity (TA) and total dissolved inorganic carbon (TCO2) within sea ice and seawater, we estimated ikaite precipitated up to 167 ± 3 µmol kg-1 within sea ice; up to 57 % of the ikaite precipitated within sea ice was exported to the underlying seawater where it was dissolved. Ikaite export from the ice to the underlying seawater was associated with brine rejection during sea ice growth, increased sea ice vertical connectivity due to the upward percolation of seawater, and meltwater flushing during sea ice melt. The dissolution of the ikaite crystals in the water column kept the seawater pCO2 undersaturated compared to the atmosphere in spite of increased salinity, TA, and TCO2 associated with sea ice growth. Results indicate that ikaite export from sea ice and its dissolution in the underlying seawater can potentially hamper the effect of oceanic acidification on the aragonite saturation state (Ωaragonite) in fall and winter in ice-covered areas, at the time when Ωaragonite is smallest. [less ▲]

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See detailJohn of Trevisa légitimise la traduction en langue anglaise (vers 1387)
Dor, Juliette ULg

in The Medieval Translator. Traduire au Moyen Âge (in press), TMT 16

A l'instar de Chaucer ou des milieux wyclifiens, Trevisa revendique pour le nouveau lectorat/auditorat vernaculaire le droit d'accéder au savoir. Il s'appuie notamment sur la "translatio studii", le ... [more ▼]

A l'instar de Chaucer ou des milieux wyclifiens, Trevisa revendique pour le nouveau lectorat/auditorat vernaculaire le droit d'accéder au savoir. Il s'appuie notamment sur la "translatio studii", le modèle français et l'autorité culturelle qu'avait connue l'anglais avant Hastings. [less ▲]

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See detailErnst Mach, psychologue de la forme ?
Zincq, Aurélien ULg

in Philosophie (in press)

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See detailMoisture content determination in an antibody-drug conjugate freeze-dried medicine by near-infrared spectroscopy: a case study for release testing
Clavaud, Matthieu ULg; Roggo, Yves; Dégardin, Klara et al

in Journal of Pharmaceutical & Biomedical Analysis (in press)

The use of Near-infrared spectroscopy (NIRS) as a fast and non-destructive technique was employed for moisture content (MC) determination in Antibody-drug conjugates (ADCs) in replacement to Karl Fischer ... [more ▼]

The use of Near-infrared spectroscopy (NIRS) as a fast and non-destructive technique was employed for moisture content (MC) determination in Antibody-drug conjugates (ADCs) in replacement to Karl Fischer (KF) method. The lab analysis of ADCs, high potent medicines, should be performed in conditions ensuring the operator’s safety and using secured analytical tools like NIRS. A NIRS method was first developed and validated in compliance with current guidelines. The novelty of this work first lies in the large number of samples prepared for a wide moisture calibration range of 0.51% to 4.01%. Then, the classical Partial Least Square (PLS) regression was used as chemometric tool for the computation of the model. Excellent predictive calibration results were shown. A coefficient of correlation (r) value of 0.99 was obtained. An intercept value of 0.02 and a slope of 0.99 were observed, while the root mean square error of calibration (RMSEC) and the root mean square error of prediction (RMSEP) were respectively 0.10% and 0.12%. In addition, instrumentation, model performances and robustness of the method were evaluated, demonstrating the validation results. Calibration transfer issue and impact of the number of samples were also evaluated. Consequently, a validation strategy was introduced as a basis for submission to the health authorities’ for release and stability activities in a cGMP environment in replacement of the KF method. [less ▲]

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See detailThe addition effect of Tunisian date seed fibers on the quality of chocolate spreads
Bouaziz, M. A.; Abbes, F.; Mokni, A. et al

in Journal of Texture Studies (in press)

Novel chocolate spreads were enriched by soluble and insoluble dietary fibers from Tunisian Deglet Nour date seeds at 1, 2, 3, 4 and 5% levels in the conventional chocolate spread. Defatted Deglet Nour ... [more ▼]

Novel chocolate spreads were enriched by soluble and insoluble dietary fibers from Tunisian Deglet Nour date seeds at 1, 2, 3, 4 and 5% levels in the conventional chocolate spread. Defatted Deglet Nour date seeds (DNDS), date seed soluble fiber concentrate (DSSFC) and date seed insoluble fiber concentrate (DSIFC) were characterized by high levels of dietary fibers (80 – 90%). Chocolate spread enriched with 5% of DSSFC presented the highest OBC (304.62%) compared to the control (102%). Whatever the DSIFC and DSSFC incorporation levels, no significant difference was recorded between the firmness, chewiness and adhesiveness of prepared chocolate spreads compared to the control (P<0.05). Sensory evaluation revealed that all prepared chocolate spreads enriched by DSIFC and DSSFC were accepted by panelists. These results indicated the value of date seeds as new source of dietary fibers to develop chocolate spread and could also improve health benefits and functional properties. [less ▲]

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See detailIncreased diversification rates correlate with bisexuality in liverworts
Laenen, B.; Machac, A.; Gradstein, S.R. et al

in New Phytologist (in press)

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See detailThe Sense of Taste in Eighteenth-Century France. Flavours of Silence and Words of Perception
Von Hoffmann, Viktoria ULg

in De achttiende eeuw : Documentatieblad van de Werkgroep Achttiende Eeuw (in press)

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See detailNavigating towards decoupled aquaponic systems: A system dynamics design approach
Goddek, Simon; Espinal, Carlos; Delaide, Boris et al

in Water (in press)

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See detailLoop
Levaux, Christophe ULg

in Rock Music Studies (in press)

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See detailContribution of distribution network control to voltage stability: A case study
Aristidou, Petros ULg; Valverde, Gustavo; Van Cutsem, Thierry ULg

in IEEE Transactions on Smart Grid (in press)

A case study dealing with long-term voltage instability in systems hosting active distribution networks is reported in this paper. It anticipates future situations with high penetration of dispersed ... [more ▼]

A case study dealing with long-term voltage instability in systems hosting active distribution networks is reported in this paper. It anticipates future situations with high penetration of dispersed generation, where the latter are used to keep distribution voltages within desired limits, in complement to load tap changers. The interactions between transmission and active distribution networks are investigated on a 3108-bus test system. It involves transmission grid, large generators, and forty distribution networks, each with dispersed generation steered by a controller inspired of model predictive control. The reported simulations show the impact of distribution network voltage restoration as well as the benefit of load voltage reduction actuated by the dispersed generators. [less ▲]

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See detailAdvances in diagnosis and management of familial pituitary adenomas
JEDIDI, Haroun ULg; ROSTOMYAN, Lilith; POTORAC, Iulia et al

in International Journal of Endocrine Oncology (in press)

Familial pituitary adenomas accounts for approximately 5-8 % of all pituitary adenomas. Besides the adenomas occurring as part of syndromic entities that bring together several endocrine or other systems ... [more ▼]

Familial pituitary adenomas accounts for approximately 5-8 % of all pituitary adenomas. Besides the adenomas occurring as part of syndromic entities that bring together several endocrine or other systems disorders, 2-3% of the familial pituitary adenomas fit into the familial isolated pituitary adenomas (FIPA) syndrome. 20% of FIPA syndromes have shown mutations in the AIP gene and have distinct clinical characteristics. Recent findings have isolated a new non-AIP FIPA syndrome called X-LAG, resulting from duplication in GPR-101 gene. These new advances in the field of pituitary disease are opening up a new challenging domain to both clinician and researcher. This review will focus on these last findings and their contribution to the diagnosis and the management of familial pituitary adenomas. [less ▲]

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See detailEnabling efficient PET imaging of Synaptic Vesicle glycoprotein 2A (SV2A) with a robust and one-step radiosynthesis of a highly potent 18F-labelled ligand ([18F]UCB-H)
Warnier, Corentin ULg; Lemaire, Christian ULg; Becker, Guillaume ULg et al

in Journal of Medicinal Chemistry (in press)

We herein describe the straightforward synthesis of a stable pyridyl(4- methoxyphenyl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F ... [more ▼]

We herein describe the straightforward synthesis of a stable pyridyl(4- methoxyphenyl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F]UCB-H ([18F]7), a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A). Over the course of one year, 50 automated productions provided 34±2% of injectable [18F]7 from up to 285 GBq (7.7 Ci) of [18F]fluoride in 50 minutes (uncorrected radiochemical yield. Specific Activity = 815±185 GBq/μmol). The successful implementation of our synthetic strategy within routine, high-activity and cGMP productions attests to its practicality and reliability for the production of large doses of [18F]7. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts for the cGMP 18F-PET tracer manufacturing industry, and their ability to fulfill practical and regulatory requirements in that field. [less ▲]

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See detailPrudence et ruse comme capacités d’action managériale et politique. Le cas des équipes de direction pénitentiaire belges
Dubois, Christophe ULg

in Sociologie (in press), 7(4), 377-392

This paper aims at analysing the work of prison management teams. Working in organizations that are mainly "auto-regulated" by prison guards, governors’ teams have to cope, for the last fifteen years ... [more ▼]

This paper aims at analysing the work of prison management teams. Working in organizations that are mainly "auto-regulated" by prison guards, governors’ teams have to cope, for the last fifteen years, with a heightened control exercised by the central administration. This “regulation of control” (Reynaud, 1988) is inter alia justified by the endemic phenomenon of overcrowding and the increasing interdependency between prisons and their environment. Despite the constraints implied by these shifts, prison governors preserve some autonomy through two types of deliberative practice allowing them to influence - marginally and ethically – prison organizations and policies. The first one, called practical wisdom or prudence (Champy, 2012), lies in the subtle bypass of the rules in uncertain situations; the second one, called cunning, or ruse (Lécu, 2013), consists in denouncing the hypocrisy of some political discourses with the help of some external partners. [less ▲]

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See detailResting-state test–retest reliability of a priori defined canonical networks over different preprocessing steps
Varikuti, Deepthi; Hoffstaedter, Felix; Genon, Sarah ULg et al

in Brain Structure & Function (in press)

Resting-state functional connectivity analysis has become a widely used method for the investigation of human brain connectivity and pathology. The measurement of neuronal activity by functional MRI ... [more ▼]

Resting-state functional connectivity analysis has become a widely used method for the investigation of human brain connectivity and pathology. The measurement of neuronal activity by functional MRI, however, is impeded by various nuisance signals that reduce the stability of functional connectivity. Several methods exist to address this predicament, but little consensus has yet been reached on the most appropriate approach. Given the crucial importance of reliability for the development of clinical applications, we here investigated the effect of various confound removal approaches on the test–retest reliability of functional connectivity estimates in two previously defined functional brain networks. Our results showed that gray matter masking improved the reliability of connectivity estimates, whereas denoising based on principal components analysis reduced it. We additionally observed that refraining from using any correction for global signals provided the best test–retest reliability, but failed to reproduce anti-correlations between what have been previously described as antagonistic networks. This suggests that improved reliability can come at the expense of potentially poorer biological validity. Consistent with this, we observed that reliability was proportional to the retained variance, which presumably included structured noise, such as reliable nuisance signals (for instance, noise induced by cardiac processes). We conclude that compromises are necessary between maximizing test–retest reliability and removing variance that may be attributable to non-neuronal sources. [less ▲]

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See detailMetabolic variability in bioprocessing : implications of microbial phenotypic heterogeneity
Delvigne, Frank ULg; Zune, Quentin ULg; Lara, Alvaro et al

in Trends in Biotechnology (in press)

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See detailHenry Flynt : Catalogue des oeuvres
Levaux, Christophe ULg

in Revue et Corrigée (in press), 109

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See detailMotiver sans contraindre, séduire sans manipuler
Defays, Jean-Marc ULg

in Le Langage et l'Homme (in press)

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See detailPhysiological and bio-functional properties of gum arabic: a notable interest for certain human diseases
Eloundou Mballa, Pierre; Goffin, Dorothée ULg; Destain, Jacqueline ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (in press)

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See detailCo-simulation of Electromagnetic Transients and Phasor Models: a Relaxation Approach
Plumier, Frédéric ULg; Aristidou, Petros; Geuzaine, Christophe ULg et al

in IEEE Transactions on Power Delivery (in press)

Co-simulation opens new opportunities to combine mature ElectroMagnetic Transients (EMT) and Phasor-Mode (PM) solvers, and take advantage of their respective high accuracy and execution speed. In this ... [more ▼]

Co-simulation opens new opportunities to combine mature ElectroMagnetic Transients (EMT) and Phasor-Mode (PM) solvers, and take advantage of their respective high accuracy and execution speed. In this paper, a relaxation approach is presented, iterating between an EMT and a PM solver. This entails interpolating over time the phasors of the PM simulation, extracting phasors from the time evolutions of the EMT simulation, and representing each sub-system by a proper multiport equivalent when simulating the other sub-system. Various equivalents are reviewed and compared in terms of convergence of the PM-EMT iterations. The paper also considers the update with frequency of the Thévenin impedances involved in the EMT simulation, the possibility to compute the EMT solution only once per time step, and the acceleration of convergence through a prediction over time of the boundary variables. Results are presented on a 74-bus, 23-machine test system, split into one EMT and one PM sub-system with several interface buses. [less ▲]

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See detailHigh spatial resolution of late-Holocene human activities in the moist forests of central Africa using soil charcoal and charred botanical remains
Morin, Julie ULg; Biwolé, Achille; Gorel, Anaïs ULg et al

in Holocene (in press)

Palaeoecological and archaeological studies have demonstrated that human populations have long inhabited the moist forests of central Africa. However, spatial and temporal patterns of human activities ... [more ▼]

Palaeoecological and archaeological studies have demonstrated that human populations have long inhabited the moist forests of central Africa. However, spatial and temporal patterns of human activities have hardly been investigated with satisfactory accuracy. In this study, we propose to characterize past human activities at local scale by using a systematic quantitative and qualitative methodology based on soil charcoal and charred botanical remains. A total of 88 equidistant test-pits were excavated along six transects in two contrasting forest types in southern Cameroon. Charred botanical remains were collected by water-sieving and sorted by type (wood charcoals, oil palm endocarps, and unidentified seeds). A total of 50 Accelerator Mass Spectrometry 14C dates were also obtained. Results showed that charred macroremains were found at multiple places in the forest, suggesting scattered human activities, which were distributed into two main periods (Phase A: 2300-1300 BP – Phase B: 580 BP to the present). Charred botanical remains indicated two types of land use: (i) domestic, with oil palm endocarps most often associated with potsherds (villages) and (ii) agricultural, with charcoal as probable remnant of slash-and-burn cultivation (fields). Oil palm endocarp abundance decreased with distance from the identified human settlements. Our methodology allowed documenting, at high resolution, the spatial and temporal patterns of human activities in central African moist forests and could be applied to other tropical contexts. [less ▲]

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See detailOpen Science: a revolution in sight?
Rentier, Bernard ULg

in Interlending & Document Supply (in press)

• Purpose This article aims at describing the evolution of scientific communication, largely represented by the publication process. It notes the disappearance of the traditional publication on paper and ... [more ▼]

• Purpose This article aims at describing the evolution of scientific communication, largely represented by the publication process. It notes the disappearance of the traditional publication on paper and its progressive replacement by electronic publishing, a new paradigm implying radical changes in the whole mechanism. It aims also at warning the scientific community about the dangers of some new avenues and why, rather than subcontracting an essential part of its work, it must take back a full control of its production. • Design/methodology/approach The article reviews the emerging concepts in scholarly publication and aims to answer frequently asked questions concerning free access to scientific literature as well as to data, science and knowledge in general. • Findings The article provides new observations concerning the level of compliance to institutional open access mandates and the poor relevance of journal prestige for quality evaluation of research and researchers. The results of introducing an open access policy at the University of Liège are noted. • Social implications Open access is, for the first time in human history, an opportunity to provide free access to knowledge universally, regardless of either the wealth or the social status of the potentially interested readers. It is an essential breakthrough for developing countries. • Value Open access and Open Science in general must be considered as common values that should be shared freely. Free access to publicly generated knowledge should be explicitly included in universal human rights. There are still a number of obstacles hampering this goal, mostly the greed of intermediaries who persuade researchers to give their work for free, in exchange for prestige. The worldwide cause of Open Knowledge is thus a major universal issue for the 21st Century. [less ▲]

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See detailAqueous sol-gel synthesis and film deposition methods for the large-scale manufacture of coated steel with self-cleaning properties
Mahy, Julien ULg; Léonard, Géraldine ULg; Pirard, Sophie ULg et al

in Journal of Sol-Gel Science and Technology (in press)

A process has been developed to enable the large scale production of pure TiO2 films deposited on 316L stainless steel in order to get an easy-to-clean surface. This large scale process requires an easy ... [more ▼]

A process has been developed to enable the large scale production of pure TiO2 films deposited on 316L stainless steel in order to get an easy-to-clean surface. This large scale process requires an easy aqueous sol-gel procedure for the synthesis of the TiO2 sol. This synthesis has been simplified to facilitate the extrapolation towards an industrial scale. Results of TEM, photocatalytic properties, film hydrophilicity, and texture obtained with the simplified aqueous sol-gel synthesis (IsoP-TiO2 synthesis) show similar properties to those obtained with the standard aqueous sol-gel synthesis of TiO2 (HAc-TiO2 synthesis) developed previously. Only X-Ray Diffraction patterns showed differences, with the presence of anatase-brookite phases in IsoP-TiO2 synthesis while anatase phase only was observed in HAc-TiO2 synthesis. Both the aqueous sol-gel synthesis of pure TiO2 and the film deposition on steel by roll-coating have been successfully extrapolated to a larger scale. The photocatalytic activity and the hydrophilicity of the film were found to be unchanged when compared to films produced at a laboratory scale, thus validating the production of an efficient easy-to-clean material. Although some problems are still to be solved, this study is a hopeful first step in the development of a large scale process for self-cleaning steel production. [less ▲]

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See detailBeyond survival and uncertainty. The livelihood practices of former Gécamines workers (D.R.Congo)
Rubbers, Benjamin ULg

in Review of African Political Economy (in press)

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See detailState Created Barriers to Exit - The Example of the Acquisition of Alstom by General Electric
Petit, Nicolas ULg

in Competition Policy International (in press)

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See detailSiting Controversies Analysis: Framework and Method for Questioning the Procedure
Rossignol, Nicolas ULg; Parotte, Céline ULg; Joris, Geoffrey ULg et al

in Journal of Risk Research (in press)

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the ... [more ▼]

Siting controversies are commonplace, as well against the construction of roads, railways, nuclear waste disposals, as against windfarms. Local citizens resist against siting decisions taken by the authorities, following a dynamics often quoted as ‘Not In My Back Yard’. Yet contested for its lack of analytical value, NIMBY is still used strategically by actors to qualify citizens as irrational and egoistic. Beyond this labelling, many factors are investigated to understand the dynamics behind siting controversies. In this paper, we focus on the impact of the legal procedure structuring the implantation of windfarms in the Walloon Region (Belgium), and its translations within different decision making processes in specific case studies. To that regard, we consider the legal procedure as a ‘public policy instrument’. It is neither neutral nor natural, and carry values and interests. It organizes inter-personal relations between actors, and is potentially catalyzer of frustrations. In addition, this legal procedure is the object of translations within different contexts, including different actors participating to specific decision making processes. The empirical approach of this paper is based on case studies data and on the use of an innovative methodology called ‘Open Process Workshop’. This methodology consists in a structured workshop with key stakeholders, during which the legal procedure is questioned. Overall, we demonstrate that the focus on the legal procedure - and its translations within different decision making processes - allows systemic analysis providing deep understandings of controversies and reaffirming the interlinks between ‘the social’ and ‘the technical’ in such controversies. In addition, we argue that the methodology used fosters the production of innovative knowledge, mutual understanding and collective learning between the participants. [less ▲]

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See detailBioclimatism in Architecture : an evolutionary perspective
Nguyen, Anh Tuan; Reiter, Sigrid ULg

in International Journal of Design and Nature and Ecodynamics (in press)

Fundamentals of vernacular architecture have been used in bioclimatic architecture which has gradually become the inspiration of various movements in contemporary architecture. The study points out that ... [more ▼]

Fundamentals of vernacular architecture have been used in bioclimatic architecture which has gradually become the inspiration of various movements in contemporary architecture. The study points out that the development of bioclimatism in architecture has followed the pattern of a natural evolutionary process in which “natural selection” is likely motivated by several factors, including resources and environment problems, and driven by different mechanisms including novel building design concepts and methods, new standards and codes, discoveries in building science and construction costs. This study is an effort aimed to clarify the evolution process of the bioclimatic approach in architecture over time and its influences on contemporary movements in architecture. The paper shows also that the evolutionary theory generated new scientific tools able to improve building design thanks to simulation-based optimization methods applied to building performances. Finally, this study investigates new motivations in the era of climate change whose effects are expected to introduce more challenges as well as more trends towards a sustainable built environment through the new concept of Eco-adaptive architecture. [less ▲]

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See detailDistances between nested densities and a measure of the impact of the prior in Bayesian statistics
Ley, Christophe; Reinert, Gesine; Swan, Yvik ULg

in Annals of Applied Probability (in press)

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See detailRobbe-Grillet va plus loin avec l'Express... Le romancier face à l'entretien journalistique
Lorent, Fanny ULg

in Interférences Littéraires = Literaire Interferenties (in press)

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See detailDirect prediction of spatially and temporally varying physical properties from time-lapse electrical resistance data
Hermans, Thomas ULg; Oware, Erasmus; Caers, Jef

in Water Resources Research (in press)

Time-lapse applications of electrical methods have grown significantly over the last decade. However, the quantitative interpretation of tomograms in terms of physical properties, such as salinity ... [more ▼]

Time-lapse applications of electrical methods have grown significantly over the last decade. However, the quantitative interpretation of tomograms in terms of physical properties, such as salinity, temperature or saturation, remains difficult. In many applications, geophysical models are transformed into hydrological models, but this transformation suffers from spatially and temporally varying resolution resulting from the regularization used by the deterministic inversion. In this study, we investigate a prediction-focused approach (PFA) to directly estimate subsurface physical properties with electrical resistance data, circumventing the need for classic tomographic inversions. First, we generate a prior set of resistance data and physical property forecast through hydrogeological and geophysical simulations mimicking the field experiment. We reduce the dimension of both the data and the forecast through principal component analysis in order to keep the most informative part of both sets in a reduced dimension space. Then, we apply canonical correlation analysis to explore the relationship between the data and the forecast in their reduced dimension space. If a linear relationship can be established, the posterior distribution of the forecast can be directly sampled using a Gaussian process regression where the field data scores are the conditioning data. In this paper, we demonstrate PFA for various physical property distributions. We also develop a framework to propagate the estimated noise level in the reduced dimension space. We validate the results by a Monte Carlo study on the posterior distribution and demonstrate that PFA yields accurate uncertainty for the cases studied. [less ▲]

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See detailA new, challenging benchmark for nonlinear system identification
Tiso, Paolo; Noël, Jean-Philippe ULg

in Mechanical Systems & Signal Processing (in press)

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by ... [more ▼]

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by challenging the community through a new benchmark structure exhibiting complex nonlinear dynamics. The proposed structure consists of two o ffset cantilevered beams connected by a highly flexible element. For increasing forcing amplitudes, the system sequentially features linear behaviour, localised nonlinearity associated with the buckling of the connecting element, and distributed nonlinearity resulting from large elastic deformations across the structure. A finite element-based code with time integration capabilities is made available at http://sem.org/TDIV-Nonlin.asp. This code permits the numerical simulation of the benchmark dynamics in response to arbitrary excitation signals. [less ▲]

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See detailLes différentes modalités d’évaluation en accompagnement collectif.
Bernard, Nicolas; Faulx, Daniel ULg

in Education Permanente (in press)

L’accompagnement collectif constitue un mode de développement des individus et des équipes qui bénéficie aujourd’hui d’une abondante littérature méthodologique et théorique. Bien que cette question soit ... [more ▼]

L’accompagnement collectif constitue un mode de développement des individus et des équipes qui bénéficie aujourd’hui d’une abondante littérature méthodologique et théorique. Bien que cette question soit moins documentée actuellement, l’accompagnement collectif met en jeu également des démarches d’évaluation qui viennent en appui du processus. Basé sur quatre études de cas, cet article propose une modélisation des différentes possibilités d’évaluations, triées en fonction de quatre critères (niveaux, temporalités, contenus, formes). Chaque modalité est illustrée à l’aide d’un cas fil rouge. Cela débouche sur une multiplicité de possibilités d’application de l’évaluation au service de l’accompagnement. Nous terminons par discuter comment cette pratique peut être théorisée en termes de posture épistémologique. [less ▲]

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See detailGoat breeding in the rural district of Chemini (Algeria)
Moula, Nassim ULg; Ait Kaki, Asma; Touazi, Leghel et al

in Nature & Technology (in press)

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of ... [more ▼]

The Kabyle goat breed represents 10.52% of the total Algerian market (3.8 million heads). A survey of 69 farmers has been carried out in order to characterize it and its breeding in the District of Chemini. The questions focused on household agricultural activities, including breeding of goats, cattle, sheep, rabbits, chicken, turkeys, honeybees and the production of olive oil and figs. The goat morpho-biometric characterization was based on 18 corporal measurements. The Hierarchical Cluster Analysis (HCA) of the farm structures defined four groups of farms, variance between groups accounting for 55.7% of total variability. The average number of goats in groups 1 to 4 was 7.2±2.8, 11.1±3.5, 22.3±1.4 and 3.4±1.0, respectively. Group 3 (n=6), showed the greatest number; it consists of older farmers (67 years old or over) not practicing arboriculture. They also have the largest numbers of sheep (48.67), rabbits (50.83), chicken (48.33) and turkeys (42). Group 4 (n=9), with the lowest number of goats, was the group of young farmers (39 years old or less), more dedicated to cattle breeding (~52 heads) and the production of olive oil (~207 trees) and figs (~47 trees). The 18 morpho-biometric variables were significantly higher in males than in females (p<0.05). The Kabyle goat is small (Height at withers: male: 68.23±0.97cm and female: 65.41±0.55cm) with long hair (male: 12.24±0.51cm, and female: 9.51±0.29cm). Its ears are drooping, its convex profile has a slightly pronounced nasal split and its dress color ranges from dark brown to black. This adapted genetic resource should be key in the development of a local production, based on a strong commitment of farmers inside a breed association, for the production of specimens corresponding to a standard, to be determined collectively. [less ▲]

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