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See detailVehicle routing problems with loading constraints: State-of-the-art and future directions
Pollaris, Hanne; Braekers, Kris; Caris, An et al

in OR Spectrum (2015), 37(Issue 2), 297-330

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring ... [more ▼]

Distributors are faced with loading constraints in their route planning, e.g.,multi-dimensional packing constraints, unloading sequence constraints, stability constraints and axle weight limits. Ignoring these constraints impairs planning and induces last-minute changes resulting in additional costs. Developing vehicle routing models incorporating loading constraints is critical to more efficient route planning. The last couple of years has seen a huge increase of contributions to this field of research with almost 60 % of these being published after 2009. Our contribution is twofold. First, we overview the recent developments in the literature on all vehicle types in which loading constraints play a key role (trucks, airplanes, ships, and automated guided vehicles), using a state-of-the-art classification scheme to identify the loading constraints considered in each article. Second, we identify research gaps and opportunities for future research. [less ▲]

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See detailTime’s Up! Involvement of Metamemory Knowledge, Executive Functions, and Time Monitoring in Children’s Prospective Memory Performance
Geurten, Marie ULg; Lejeune, Caroline ULg; Meulemans, Thierry ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2015)

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring ... [more ▼]

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring strategy depending on the ongoing task’s difficulty. Specifically, a sample of 72 typically developing children aged 4, 6, and 9 years old were given an original PM paradigm composed of both an ongoing procedural activity and a PM task. Half of the participants (expert group) were trained in the ongoing activity before the prospective test. As expected, results show that time monitoring had a positive effect on children’s PM performance. Furthermore, mediation analyses reveal that strategic time monitoring was predicted by metamemory knowledge in the expert group but only by executive functions in the novice group. Overall, these findings provide interesting avenues to explain how metamemory knowledge, strategy use, and executive functions interact to improve PM performance during childhood. [less ▲]

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See detailLe genre Guibourtia Benn., un taxon à haute valeur commerciale et sociétale (synthèse bibliographique)
Tosso, Dji-ndé Félicien ULg; Daïnou, Kasso ULg; Hardy, J. Olivier et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1),

Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and ... [more ▼]

Known as a genus of great socio-cultural and economical importance, Guibourtia Benn. includes morphologically very similar multipurpose sister species, found in various habitats with different climate and soil conditions. In many places, Guibourtia is subject to local overexploitation by forest companies and local communities. As the population density of Guibourtia species is generally very low, it may be necessary to conduct scientific investigations that will provide valuable information for the management of the populations concerned. This paper is based on an extensive literature review and summarizes the available information on the genus Guibourtia, in terms of botany, ecology, genetics, forestry and ethnobotany. Our review provided evidence that, to date, ecological and silvicultural knowledge regarding Guibourtia species is lacking and that it is very difficult to morphologically differentiate very similar sister species. In addition, we provide a new determination key for the genus Guibourtia. Based on the available information, it is difficult to assess the conservation status of these taxa. Further investigations are needed to suggest appropriate management strategies for Guibourtia. Moreover, species diversity within this genus and its distribution in various tropical biomes make it an excellent biological model for understanding the historical, biological and environmental mechanisms that explain the diversity of tropical moist forests. [less ▲]

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See detailValidation and Psychometric Properties of the French Versions of the Environmental Reward Observation Scale and of the Reward Probability Index
Wagener, Aurélie ULg; Blairy, Sylvie ULg

in Psychologica Belgica (2015)

Background: Low levels of environmental rewards have been related to depression on a number of occasions in the scientific literature. Two scales have been created to assess environmental rewards: the ... [more ▼]

Background: Low levels of environmental rewards have been related to depression on a number of occasions in the scientific literature. Two scales have been created to assess environmental rewards: the Environmental Reward Observation Scale (EROS) and the Reward Probability Index (RPI). This study aims to validate the French versions of these two scales. Method: 466 non-clinical adults completed an online survey assessing environmental rewards, depression, anxiety, activation, avoidance and behavioural systems. Confirmatory factor analyses were performed to assess the factorial structures of the French EROS and RPI. Results: A one-factor solution for the EROS and a two-factor solution for the RPI best fitted the data. High levels of internal consistency were found for both the EROS and the RPI. Convergent validity was also examined, revealing that high environmental rewards appear to be related to activation and behavioural activation system. Conclusion: The French versions of the EROS and the RPI appear to be reliable assessments of environmental rewards. [less ▲]

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See detailThe enfranchisement of citizens abroad: variations and explanations
Lafleur, Jean-Michel ULg

in Democratization (2015)

Today, a large majority of states allow at least some of their emigrants to take part in home country elections from abroad. This article first looks at the diffusion of external voting laws and shows ... [more ▼]

Today, a large majority of states allow at least some of their emigrants to take part in home country elections from abroad. This article first looks at the diffusion of external voting laws and shows that over the past 25 years they have become widely-adopted and are no longer limited to specific professional categories of citizens. Second, the article explains the international diffusion of external voting by discussing the “norm- internationalization hypothesis” and the “electoral-competition hypothesis.” Third, the article attempts to demonstrate that these hypotheses cannot explain why, in a democratic context, states continue to implement a series of hurdles that deter emigrants from using their newly gained rights. Looking at recent developments in Latin America and the Middle East and North Africa, it concludes that the diffusion and variations of external voting laws result from transnational negotiation processes in a context of democratic transformation among various actors whose interests are strongly affected by the inclusion or exclusion of these new voters. [less ▲]

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See detailIntroduction - Postcolonial Thresholds: Gateways and Borders
Wilson, Janet; Tunca, Daria ULg

in Journal of Postcolonial Writing (2015), 51(1), 1-6

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See detailWithdrawal of Immunomodulators After Co-treatment Does Not Reduce Trough Level of Infliximab in Patients With Crohn's Disease.
Drobne, David; Bossuyt, Peter; Breynaert, Christine et al

in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (2015), 13(3), 514-5214

BACKGROUND & AIMS: The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated ... [more ▼]

BACKGROUND & AIMS: The addition of immunomodulators increases the efficacy of maintenance therapy with infliximab for up to 1 year in patients with Crohn's disease who have not been previously treated with immunomodulators. However, there are questions about the effect of withdrawing immunomodulator therapy from these patients. We studied the effects of treatment with infliximab and immunomodulators (co-treatment) and then immunomodulator withdrawal on long-term outcomes of patients, as well as trough levels of infliximab and formation of anti-infliximab antibodies (ATI). METHODS: In a retrospective study with the median follow-up period of 34 months (interquartile range, 19-58 months), we analyzed data from 223 patients treated for Crohn's disease between May 1999 and December 2010 at the University Hospitals, Leuven, Belgium (65 received infliximab monotherapy, 158 received infliximab and an immunomodulator). Trough levels of infliximab and levels of ATI were measured in blood samples collected from 117 patients throughout co-treatment, as well as the time of immunomodulator withdrawal and after withdrawal. RESULTS: Patients receiving co-treatment had higher trough levels of infliximab (adjusted mean increase, 1.44-fold) than those receiving infliximab monotherapy (95% confidence interval [CI], 1.07-1.92; P = .02). A smaller percentage of patients receiving co-treatment developed ATI (35 of 158, 22%) than those receiving infliximab monotherapy (25 of 65, 38%; P = .01). Among co-treated patients, levels of infliximab remained stable after immunomodulators were withdrawn (before: 3.2 mug/mL; 95% CI, 1.6-5.8 mug/mL and after: 3.7 mug/mL; 95% CI, 1.3-6.3 mug/mL; P = .70). After withdrawal of immunomodulators, 45 of 117 patients (38%) required increasing doses of infliximab, and 21 of 117 (18%) discontinued infliximab. At the time of immunomodulator withdrawal, trough levels of infliximab and C-reactive protein were most strongly associated with response to infliximab thereafter. CONCLUSIONS: In a retrospective analysis, we confirmed that withdrawal of immunomodulators after at least 6 months (median, 13 months) of co-treatment with infliximab does not reduce the trough levels of infliximab in patients with Crohn's disease. Detectable trough levels of infliximab at the time of immunomodulator withdrawal are associated with long-term response. [less ▲]

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See detailNew data on the recent history of the littoral forests of southern Cameroon: an insight into the role of historical human disturbances on the current forest composition
Biwolé, Achille ULg; Morin-Rivat, Julie ULg; Fayolle, Adeline ULg et al

in Plant Ecology and Evolution (2015), 148(1), 19-28

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they ... [more ▼]

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they were progressively concentrated in villages along roads, leaving large areas of forest derelict. In south-western Cameroon, and elsewhere in Central Africa, forest canopy is dominated by long-lived lightdemanding tree species, suggesting a possible role of human disturbance. The aim of this study was to bring new insights into the possible effect of historical human disturbances in terms of timing and spatial extent on the current forest composition. Location – Wet evergreen littoral forest in south-western Cameroon. Methods and key results – A combined vegetation sampling and archaeobotanical survey were conducted. Potsherds, oil-palm endocarps, and charcoal were found throughout the study area, suggesting generalised human occupation and anthropogenic fire. Human occupancy occurred in two periods: between 2200 and 1500 BP, and, more recently, beginning three centuries ago. High frequency of fire and the presence of Elaeis guineensis both dated recently (between 260 and 145 BP) suggest slash-and-burn shifting cultivation practices. These human-induced disturbances may coincide with the age of the current emergent lightdemanding species, the age of which can be estimated around 200 years, or with the phases of drying climate recorded in the Central African forest in the early 18th century. Conclusions – These results support the idea that historical human disturbances are one of the major factors that shaped the current forest composition in Central Africa. [less ▲]

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See detailDevelopment and validation of the French version of a tool assessing patient's expectations in lower limb osteoarthritis
NEUPREZ, Audrey ULg; Delcour, JP; Fatemi, F et al

in Journal of Orthopaedics (2015), 12

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See detailSynthesis and tensioactive properties of PEO-b-polyphosphate copolymers
Vanslambrouck, Stéphanie ULg; Clément, Benoit; Riva, Raphaël ULg et al

in RSC Advances (2015), 5(35), 27330-37337

Poly(ethylene oxide) (PEO)-b-polyphosphate copolymers made of hydrophilic PEO and hydrophobic polyphosphates are amphiphilic copolymers prone to self-assemble in water into nanoparticles. In this work ... [more ▼]

Poly(ethylene oxide) (PEO)-b-polyphosphate copolymers made of hydrophilic PEO and hydrophobic polyphosphates are amphiphilic copolymers prone to self-assemble in water into nanoparticles. In this work, nanoparticles are obtained by the self-assembly of PEO-b-polyphosphate copolymers in water in the absence of any organic co-solvent whatever the length of the pendant alkyl chain (between 4 and 7 carbon atoms) of the polyphosphate block. Remarkably, this solvent-free process remains efficient even for the most hydrophobic polyphosphate blocks. The critical aggregation concentration (CAC) of the block copolymers was determined by pyrene probe fluorescence. Finally, the efficiency of these copolymer surfactants to decrease the air–water interface was measured by air-bubble tensiometry. [less ▲]

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See detailExtracellular peptidase hunting for improvement of protein production in plant cells and roots
Lallemand, Jérôme ULg; Bouché, Frédéric ULg; Desiron, Carole et al

in Frontiers in Plant Science (2015), 6(37),

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now ... [more ▼]

Plant-based recombinant protein production systems have gained an extensive interest over the past few years, because of their reduced cost and relative safety. Although the first products are now reaching the market, progress are still needed to improve plant hosts and strategies for biopharming. Targeting recombinant proteins toward the extracellular space offers several advantages in terms of protein folding and purification, but degradation events are observed, due to endogenous peptidases. This paper focuses on the analysis of extracellular proteolytic activities in two production systems: cell cultures and root-secretion (rhizosecretion), in Arabidopsis thaliana and Nicotiana tabacum. Proteolytic activities of extracellular proteomes (secretomes) were evaluated in vitro against two substrate proteins: bovine serum albumin (BSA) and human serum immunoglobulins G (hIgGs). Both targets were found to be degraded by the secretomes, BSA being more prone to proteolysis than hIgGs. The analysis of the proteolysis pH-dependence showed that target degradation was mainly dependent upon the production system: rhizosecretomes contained more peptidase activity than extracellular medium of cell suspensions, whereas variations due to plant species were smaller. Using class-specific peptidase inhibitors, serine and metallopeptidases were found to be responsible for degradation of both substrates. An in-depth in silico analysis of genomic and transcriptomic data from Arabidopsis was then performed and led to the identification of a limited number of serine and metallo-peptidases that are consistently expressed in both production systems. These peptidases should be prime candidates for further improvement of plant hosts by targeted silencing. [less ▲]

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See detailCharacterization of collagen fibrils after equine suspensory ligament injury: an ultrastructural and biochemical approach
Shikh Al Sook, Mohamad Khir ULg; Gabriel, Annick ULg; Salouci, Moustafa et al

in The Veterinary Journal (2015)

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril ... [more ▼]

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril morphology, as well as the collagen content and types. The purpose of this study was to evaluate, using biochemical and ultrastructural approaches, the alterations in collagen fibrils after injury. Eight Warmblood horses with visible signs of injury in only one forelimb SL were selected and specimens were examined by transmission electron microscope (TEM). Collagen types I, III and V were purified by differential salt precipitation after collagen extraction with acetic acid containing pepsin. TEM revealed abnormal organization as well as alterations in the diameter and shape of fibrils after SL injury. The bands corresponding to types I, III and V collagen were assessed by densitometry after sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Densitometric analysis indicated that the proportions of type III and type V collagen were significantly higher (P <0.001) in damaged tissues compared to normal tissues with a mean increase of 20.9 and 17.3% respectively. Concurrently, a significant decrease (P <0.001) in type I collagen within damaged tissues was recorded with a mean decrease of 15.2%. These alterations could be the hallmark of a decrease in the tissue quality and mechanical properties of the ligament. This provides new insight for subsequent research on tissue regeneration that may lead to the development of future treatment strategies for SL injury. [less ▲]

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See detailA Membrane-Type-1 Matrix Metalloproteinase (MT1-MMP) - Discoidin Domain Receptor 1 Axis Regulates Collagen-Induced Apoptosis in Breast Cancer Cells.
Assent, Delphine; Bourgot, Isabelle ULg; Hennuy, Benoît ULg et al

in PloS one (2015), 10(3), 0116006

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To ... [more ▼]

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we have previously demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. Here we performed a transcriptomic analysis to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was performed. Shifting the cells from plastic plates to 3D COL1 activated a complex reprogramming of genes implicated in various biological processes. Bioinformatic analysis revealed a 3D COL1-mediated alteration of key cellular functions including apoptosis, cell proliferation, RNA processing and cytoskeleton remodelling. By using a panel of pharmacological inhibitors, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase specifically activated by collagen, as the initiator of 3D COL1-induced apoptosis. Our data support the concept that MT1-MMP contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering a drastic remodelling of the transcriptome of MCF-7 cells. [less ▲]

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See detailBioaccumulation of organohalogenated compounds in sharks and rays from the southeastern USA
Weijs, Liesbeth; Briels, Nathalie; Adams, Douglas et al

in Environmental Research (2015), 137

Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the ... [more ▼]

Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the concentrations of POPs (persistent organic pollutants) and of MeO-PBDEs (methoxylated polybrominated diphenyl ethers) in elasmobranchs is scarce and potential toxic effects are poorly understood. The aims of the present study were therefore to investigate the occurrence of multiple POP classes (PCBs, PBDEs, DDXs, HCB, CHLs) and of MeO-PBDEs in various elasmobranch species from different trophic levels in estuarine and marine waters of the southeastern United States. Overall, levels and patterns of PCBs, PBDEs, DDXs, HCB, CHLs and of MeO-PBDEs varied according to the species, maturity stage, gender and habitat type. The lowest levels of POPs were found in Atlantic stingrays and the highest levels were found in bull sharks. As both species are respectively near the bottom and at top of the trophic web, with juvenile bull sharks frequently feeding on Atlantic stingrays, these findings further suggest a bioaccumulation and biomagnification process with trophic position. MeO-PBDEs were not detected in Atlantic stingrays, but were found in all shark species. HCB was not found in Atlantic stingrays, bonnetheads or lemon sharks, but was detected in the majority of bull sharks examined. Comparison with previous studies suggests that Atlantic stingrays may be experiencing toxic effects of PCBs and DDXs on their immune system. However, the effect of these compounds on the health of shark species remains unclear. [less ▲]

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See detailAllogeneic hematopoietic stem cell transplantation in solid organ transplant recipients: a retrospective, multicenter study of the EBMT
Basak, GW.; Wiktor-Jedrzejczak, W.; Labopin, M. et al

in American Journal of Transplantation (2015), 15

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in ... [more ▼]

We conducted a questionnaire survey of the 565 European Society for Blood and Marrow Transplantation centers to analyze the outcome of allogeneic hematopoietic stem cell transplantation (alloSCT) in recipients of solid organ transplantation (SOT). We investigated 28 patients with malignant (N=22) or nonmalignant diseases (N=6), who underwent 31 alloSCT procedures: 12 after kidney, 13 after liver, and three after heart transplantation. The incidence of solid organ graft failure at 60 months after first alloSCT was 33% (95% confidence interval [CI], 16–51%) for all patients, 15% (95% CI, 2–40%) for liver recipients, and 50% (95% CI, 19–75%) for kidney recipients (p = 0.06). The relapse rate after alloSCT (22%) was low following transplantation for malignant disorders, despite advanced stages of malignancy. Overall survival at 60 months after first alloSCT was 40% (95% CI, 19–60%) for all patients, 51% (95% CI, 16–86%) for liver recipients, and 42% (95% CI, 14–70%) for kidney recipients (p = 0.39). In summary, we show that selected SOT recipients suffering from hematologic disorders may benefit from alloSCT and experience enhanced long-term survival without loss of organ function. [less ▲]

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See detailInternational assessment of future low flow regimes and their impact on three water related sectors in the Meuse basin – a collaborative approach
Bauwens, Alexandra; Degré, Aurore ULg; Deraedt, Deborah ULg et al

in International Journal of River Basin Management (2015), 13(1), 123-135

There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to ... [more ▼]

There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to various pre-existing regional management tools, models or even objectives. In this study we aim at describing the collaborative assessment of climate change’s effect on low flow regime and the consequences on three water related sectors: drinking water production, agriculture and electricity production. The paper highlights the choices that were made during the study that involved scientific teams, managers and stakeholders from the four main countries of the Meuse Basin. It shows that the methodological choices were operational and aimed at preserving existing methods and knowledge within each country. They led to hydrological scenarios comparable to the main available ensemble approaches and to methodologies well accepted within the concerned countries. The results of the project highlight and quantify the water scarcity that the three sectors will have to face by the end of the century mainly regarding the electricity production. They also show that common allocation rules are necessary to manage water demand during future low flow periods. [less ▲]

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See detailTrebananib (AMG 386) plus weekly paclitaxel with or without bevacizumab as first-line therapy for HER2-negative locally recurrent or metastatic breast cancer: A phase 2 randomized study.
Dieras, Veronique; Wildiers, Hans; Jassem, Jacek et al

in Breast (Edinburgh, Scotland) (2015), 24

INTRODUCTION: This phase 2 randomized study evaluated trebananib (AMG 386), a peptide-Fc fusion protein that inhibits angiogenesis by neutralizing the interaction of angiopoietin-1 and -2 with Tie2, in ... [more ▼]

INTRODUCTION: This phase 2 randomized study evaluated trebananib (AMG 386), a peptide-Fc fusion protein that inhibits angiogenesis by neutralizing the interaction of angiopoietin-1 and -2 with Tie2, in combination with paclitaxel with or without bevacizumab in previously untreated patients with HER2-negative locally recurrent/metastatic breast cancer. METHODS: Patients received paclitaxel 90 mg/m2 once weekly (3-weeks-on/1-week-off) and were randomly assigned 1:1:1:1 to also receive blinded bevacizumab 10 mg/kg once every 2 weeks plus either trebananib 10 mg/kg once weekly (Arm A) or 3 mg/kg once weekly (Arm B), or placebo (Arm C); or open-label trebananib 10 mg/kg once a week (Arm D). Progression-free survival was the primary endpoint. RESULTS: In total, 228 patients were randomized. Median estimated progression-free survival for Arms A, B, C, and D was 11.3, 9.2, 12.2, and 10 months, respectively. Hazard ratios (95% CI) for Arms A, B, and D versus Arm C were 0.98 (0.61-1.59), 1.12 (0.70-1.80), and 1.28 (0.79-2.09), respectively. The objective response rate was 71% in Arm A, 51% in Arm B, 60% in Arm C, and 46% in Arm D. The incidence of grade 3/4/5 adverse events was 71/9/4%, 61/14/5%, 62/16/3%, and 52/4/7% in Arms A/B/C/D. In Arm D, median progression-free survival was 12.8 and 7.4 months for those with high and low trebananib exposure (AUCss >/= 8.4 versus < 8.4 mg.h/mL), respectively. CONCLUSIONS: There was no apparent prolongation of estimated progression-free survival with the addition of trebananib to paclitaxel and bevacizumab at the doses tested. Toxicity was manageable. Exposure-response analyses support evaluation of combinations incorporating trebananib at doses > 10 mg/kg in this setting. TRIAL REGISTRATION: ClinicalTrials.gov, NCT00511459. [less ▲]

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See detailStellar acoustic radii, mean densities, and ages from seismic inversion techniques
Buldgen, Gaël ULg; Dupret, Marc-Antoine ULg; Reese, Daniel et al

in Astronomy and Astrophysics (2015), 574

Context. Determining stellar characteristics such as the radius, mass or age is crucial when studying stellar evolution or exoplanetary systems, or when characterising stellar populations in the Galaxy ... [more ▼]

Context. Determining stellar characteristics such as the radius, mass or age is crucial when studying stellar evolution or exoplanetary systems, or when characterising stellar populations in the Galaxy. Asteroseismology is the golden path to accurately obtain these characteristics. In this context, a key question is how to make these methods less model-dependent. Aims: Building on the previous work of Daniel Reese, we wish to extend the Substractive Optimally Localized Averages (SOLA) inversion technique to new stellar global characteristics beyond the mean density. The goal is to provide a general framework in which to estimate these characteristics as accurately as possible in low-mass main-sequence stars. Methods: First, we describe our framework and discuss the reliability of the inversion technique and possible sources of error. We then apply this methodology to the acoustic radius, an age indicator based on the sound speed derivative and the mean density, and compare it to estimates based on the average large and small frequency separations. These inversions are carried out for several test cases including various metallicities, different mixing-lengths, non-adiabatic effects, and turbulent pressure. Results: We observe that the SOLA method yields accurate results in all test cases whereas results based on the large and small frequency separations are less accurate and more sensitive to surface effects and structural differences in the models. If we include the surface corrections of Kjeldsen et al. (2008, ApJ, 683, L175), we obtain results of comparable accuracy for the mean density. Overall, the mean density and acoustic radius inversions are more robust than the inversions for the age indicator. Moreover, the current approach is limited to relatively young stars with radiative cores. Increasing the number of observed frequencies improves the reliability and accuracy of the method. [less ▲]

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See detailSafety and efficacy of azacitidine in Belgian patients with high-risk myelodysplastic syndromes, acute myeloid leukaemia, or chronic myelomonocytic leukaemia: results of a real-life, non-interventional post-marketing survey
Beguin, Yves ULg; Selleslag, Dominik; Meers, Stef et al

in Acta Clinica Belgica (2015), 70

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real ... [more ▼]

Objectives: We evaluated azacitidine (VidazaH) safety and efficacy in patients with myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML), and chronic myelomonocytic leukaemia (CMML), in a real-life setting. Treatment response, dose, and schedule were assessed. Methods: This non-interventional, post-marketing survey included 49/50 patients receiving azacitidine at 14 Belgian haematology centres from 2010–2012. Treatment-emergent adverse events (TEAEs), including treatment-related TEAEs, and serious TEAEs (TESAEs) were recorded throughout the study. Treatment response [complete response (CR), partial response (PR), haematological improvement (HI), stable disease (SD), treatment failure (TF)) and transfusion-independence (TI) were evaluated at completion of a 1-year observation period (1YOP) or at treatment discontinuation, and overall survival (OS), at study conclusion. Results: The median age of patients was 74.7 (range: 43.9–87.8) years; 69.4% had MDS, 26.5% had primary or secondary AML, and 4.1% had CMML. Treatment-related TEAEs, grade 3–4 TEAEs, and TESAEs were reported in 67.3%, 28.6%, and 18.4% of patients, respectively. During 1YOP, patients received a median of 7 (1–12) treatment cycles. Treatment response was assessed for 38/49 patients. Among MDS and CMML patients (n529), 41.4% had CR, PR, or HI, 41.4% had SD, and 17.2% had TF. Among AML patients (n59), 44.4% had CR or PR, 33.3% had SD, and 22.2% had TF. TI was observed in 14/32 (43.8%) patients who were transfusion-dependent at baseline. Median (95% confidence interval) OS was 490 (326–555) days; 1-year OS estimate was 0.571 (0.422–0.696). Conclusions: Our data support previous findings that azacitidine has a clinically acceptable safety profile and shows efficacy. [less ▲]

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See detailFarmers' practices and willingness to adopt supplemental irrigation in Burkina Faso
Zongo, Bétéo ULg; Diarra, Abdoulaye; Barbier, Bruno et al

in International Journal of Food and Agricultural Economics (2015), 3(1), 101-117

This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a ... [more ▼]

This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a diversity of farming practices within and between two agro-climatic zones. Over 65% of farmers believe that supplemental irrigation is a good way to mitigate the adverse effects of dry spells on crop yields. Determining factors of farmers’ willingness to adopt supplemental irrigation were identified using a logistic model. Lack of information is the major obstacle to promoting this innovation. Farmers’ training and information dissemination are the best ways to increase the acceptance of this promising technology. [less ▲]

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See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2015), 25(03), 570-601

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

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See detailEstimation of degree-days for different climatic zones of North-East India
Borah, Pallavi; Singh, Manoj Kumar; Mahapatra, Sadhan

in Sustainable Cities and Society (2015), 14

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See detailSingle-Walled Metal–Organic Nanotube Built from a Simple Synthon
Adarsh, Nayarassery; Dirtu, Marinela; Naik, Anil et al

in Chemistry : A European Journal (2015), 21

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See detailRoasted Sunflower Kernel Paste (Tahini) Stability: Storage Conditions and Particle Size Influence
Muresan, Vlad; Danthine, Sabine ULg; Bolboaca, Sorana D. et al

in Journal of the American Oil Chemists' Society (2015)

Sunflower tahini faces quality problems due to the tendency of oil to exudate, causing accelerated rancidity and low marketability. In this study, the colloidal and oxidative stability of different ... [more ▼]

Sunflower tahini faces quality problems due to the tendency of oil to exudate, causing accelerated rancidity and low marketability. In this study, the colloidal and oxidative stability of different trimodal particle size distributions of sunflower tahini (cumulative volume percentages of small, middle and large class populations of 9.61–16.67, 43.03–55.03 and 47.36–28.3) was evaluated during storage at three different temperatures. Decreasing sample particle size decreased the sunflower tahini colloidal stability. The coarsest prototype, being the most stable tahini in terms of oil separation, was included in the oxidative stability storage test together with a commercial tahini. The peroxide values of the studied sunflower tahini samples increased significantly (p < 0.05) with storage time, irrespective of storage temperature, while the p-anisidine values showed an irregular pattern. Considering 30-meq O2/kg as a PV limit, the commercial tahini showed good oxidative stability as it was under this when stored 3 months at 4 °C, 2 months at room temperature and 1 month a 40 °C. The coarsest tahini sample was under the limit when stored 2 months at 4 °C, 1 month at room temperature and 2 weeks at 40 °C. Particle size was shown to be an essential parameter for controlling sunflower tahini’s overall stability. [less ▲]

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See detailAre Children Conservative, Liberal or Metacognitive? Preliminary Evidence for the Involvement of the Distinctiveness Heuristic in Decision Making
Geurten, Marie ULg; Willems, Sylvie ULg; Meulemans, Thierry ULg

in Journal of Experimental Child Psychology (2015), 132

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children ... [more ▼]

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children, aged 4, 6, and 9 years, studied two lists of unrelated items. One of these lists was visually displayed (picture condition) while the other was presented auditorily (word condition). After each study phase, participants completed recognition tests. Finally, they answered questions about their explicit knowledge of the distinctive-encoding effect. The results revealed that even the youngest children in our sample showed a smaller proportion of intrusions in the picture condition than in the word condition. Furthermore, the results of the signal detection analyses were consistent with the hypothesis that the lower rate of false recognitions after picture encoding results from the implementation of a conservative response criterion based on metacognitive expectations (distinctiveness heuristic). Moreover, the absence of correlation between children’s explicit knowledge of the distinctiveness rule and their effective use of this metacognitive heuristic seems to indicate that its involvement in memory decisions could be mediated by implicit mechanisms. [less ▲]

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See detailLes supports pour l'étude fournis à l'élève en sciences biologiques sont-ils créateurs d'inégalités? Etude exploratoire de productions de futurs enseignants en Fédération Wallonie-Bruxelles (Belgique)
Poffé, Corentin ULg; Laschet, Mélanie ULg; Hindryckx, Marie-Noëlle ULg

in Spirale : Revue de Recherches en Education (2015), 55

Une revue de la littérature permet d’attribuer à de nombreux facteurs les inégalités dans l’apprentissage. Parmi ceux-ci, nous avons choisi d’analyser, avec le regard du formateur d’enseignants, les ... [more ▼]

Une revue de la littérature permet d’attribuer à de nombreux facteurs les inégalités dans l’apprentissage. Parmi ceux-ci, nous avons choisi d’analyser, avec le regard du formateur d’enseignants, les supports pour l’étude proposés par nos étudiants futurs enseignants aux élèves du secondaire (15 à 18 ans) en vue de l’évaluation, lors des cours de sciences biologiques. Cette « photographie instantanée » des supports pour l’étude nous a fourni un état des lieux qui nous permet d’objectiver nos impressions de formateurs quant au rôle des supports pour l’étude dans la problématique des inégalités scolaires. [less ▲]

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See detailComplex dynamics of a nonlinear aerospace structure: numerical continuation and normal modes
Renson, Ludovic ULg; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg

in Nonlinear Dynamics (2015), 79(2), 1293-1309

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining ... [more ▼]

This paper investigates the dynamics of a real-life aerospace structure possessing a strongly nonlinear component with multiple mechanical stops. A full-scale finite element model is built for gaining additional insight into the nonlinear dynamics that was observed experimentally, but also for uncovering additional nonlinear phenomena, such as quasiperiodic regimes of motion. Forced/unforced, damped/undamped numerical simulations are carried out using advanced techniques and theoretical concepts such as numerical continuation and nonlinear normal modes. [less ▲]

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See detailMultiple timescale spectral analysis
Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2015), 39(0), 69--86

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the ... [more ▼]

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the steady-state second order cumulant of a linear oscillator, under the action of a stationary loading prescribed by means of its power spectral density. There exists however a broad variety of such similar problems, extending the concept to multi degree-of-freedom systems, non Gaussian excitation, slightly nonlinear oscillators or even transient excitations. In this wide class of problems, the cumulants of the response are obtained as the result of the integral of corresponding spectra over the frequency space, which is possibly multidimensional. Application of standard numerical integration techniques may be prohibitive, a reason why the spectral approach is often left aside. Besides, many engineering problems involve a clear timescale separation, usually of those pertaining to the loading and to the mechanical behavior of the system. In these problems, a proper consideration of the timescale separation results in dropping the order of integration by one, at least. This offers the possibility to derive analytical solutions, whenever the order of integration drops to zero, or to make numerical integration competitive. The paper presents this general method, together with some applications in wind and marine engineering. [less ▲]

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See detailThe age of river-transported carbon: A global perspective
Marwick, Trent R.; Tamooh, Fredrick; Teodoru, Cristian R. et al

in Global Biogeochemical Cycles (2015), 29(2), 122--137

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of ... [more ▼]

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of different riverine C pools, there remain large regions for which no data are available and no comprehensive attempts to synthesize the available information and examine global patterns in the 14C content of different riverine C pools. Here we present new 14C data on particulate and dissolved organic C (POC and DOC) from six river basins in tropical and subtropical Africa and compiled >1400 literature Δ14C data and ancillary parameters from rivers globally. Our analysis reveals a consistent pattern whereby POC is progressively older in systems carrying higher sediment loads, coinciding with a lower organic carbon content. At the global scale, this pattern leads to a proposed global median Δ14C signature of −203‰, corresponding to an age of ~1800 years B.P. For DOC exported to the coastal zone, we predict a modern (decadal) age (Δ14C = +22 to +46‰), and paired data sets confirm that riverine DOC is generally more recent in origin than POC—in contrast to the situation in ocean environments. Weathering regimes complicate the interpretation of 14C ages of dissolved inorganic carbon, but the available data favor the hypothesis that in most cases, more recent organic C is preferentially mineralized. [less ▲]

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See detailOak barks as raw materials for the extraction of polyphenols for the chemical and pharmaceutical sectors: a regional case study
Dedrie, Maxime; Jacquet, Nicolas ULg; Bombeck, Pierre-Louis ULg et al

in Industrial Crops and Products (2015), 70

Despite their potential for chemical recycling, residues from forest harvesting and wood processing are mostly used for industrial applications with low added value (energy, paper pulp, panels). Bark of ... [more ▼]

Despite their potential for chemical recycling, residues from forest harvesting and wood processing are mostly used for industrial applications with low added value (energy, paper pulp, panels). Bark of both oak species, Quercus robur L. 1753, Quercus petraea (Matt.) Liebl. 1784 is a by-product from sawmill and pulp mill activities. Bark is mainly used as a fuel for the same wood plants. The aim of this study is to look at the feasibility of enhancing the value of this material through the extraction of bioactive molecules such as polyphenols (i.e. catechin, gallic and ellagic acids). First, the effect of industrial storage of logs and bark on their polyphenol content was explored. Then, referring to the selection of tan oaks in the past, the question of an optimum harvesting age is addressed in order to maximize the polyphenol content of the barks. In the end, molecular diversity of bark is examined through the identification of molecules of interest, using different chromatographic analyses. The results show an effect of the industrial context and an effect of the raw material age on the chemical properties of the bark. First investigations also highlight molecules of interest and the molecular diversity, which needs to be further explored. [less ▲]

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See detailAssessment of contaminant levels and trophic relations at a World Heritage Site by measurements in a characteristic shorebird species
Schwemmer, Philipp; Covaci, Adrian; Das, Krishna ULg et al

in Environmental Research (2015), 136

The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB ... [more ▼]

The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ-HCHs), dichlorodiphenyltrichloroethane (DDT) and its metabolites, and polybrominated diphenyl ethers (PBDEs) in blood and feathers from Eurasian oystercatchers (Haematopus ostralegus; n=28) at the Elbe and compared it with a non-riverine site about 90 km further north. (1) Mean levels of all contaminants in feathers and serum were significantly higher at the river (ƩPCBs: 27.6 ng/g feather, 37.0 ng/ml serum; ƩDDTs: 5.3 ng/g feather, 4.4 ng/ml serum) compared with the non-riverine site (ƩPCBs: 6.5 ng/g feather, 1.2 ng/ml serum; ƩDDTs: 1.4 ng/g feather, 0.5 ng/ml serum). Mean ƩHCH and HCB levels were <1.8 ng/g in feather and <1.8 ng/ml in serum at both sites. (2) Levels of most detectable compounds in serum and feathers were significantly related, but levels were not consistently higher in either tissue. (3) There was no significant relationship between trophic level in individual oystercatchers (expressed as δ15N) or the degree of terrestrial feeding (expressed as δ13C) and contaminant loads. (4) PBDEs were not detected in significant amounts at either site. The results of this study indicate that the outflow from one of Europe’s largest river systems is associated with significant historical contamination, reflected by the accumulation of contaminants in body tissues in a coastal benthivore predator. [less ▲]

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See detailEffect of enzymatic treatment on rheological properties, glass temperature transition and microstructure of date syrup
Abbès, Fatma; Masmoudi, Manel; Kchaou, Wissal et al

in LWT - Food Science and Technology (2015), 60

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes ... [more ▼]

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes (pectinase and cellulase) on rheological properties and glass temperature transition of date syrup. Date syrups obtained by enzymatic extraction exhibited a quasi Newtonian behaviour. The enzyme-treated date syrups showed the highest values of activation energy (Ea). Therefore, these syrups showed the most temperature dependency. Dynamic shear results revealed viscous behaviour for date syrups indicating that both syrups displayed liquid-like behaviour. Temperature significantly affected both (G') and (G''). The glass transition temperature (Tg) of date syrups varied between -39.56 and -45.74 °C depending on their composition. Glass transition temperature of date syrups decreased linearly with an increase in water content. [less ▲]

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See detailReview on greenhouse gas emissions from pig houses: Production of carbon dioxide, methane and nitrous oxide by animals and manure
Philippe, François-Xavier ULg; Nicks, Baudouin ULg

in Agriculture, Ecosystems & Environment (2015)

The environmental impacts of livestock production are attracting increasing attention, especially the emission of greenhouse gases (GHGs). Currently, pork is the most widely consumed meat product in the ... [more ▼]

The environmental impacts of livestock production are attracting increasing attention, especially the emission of greenhouse gases (GHGs). Currently, pork is the most widely consumed meat product in the world, and its production is expected to grow in the next few decades. This paper deals with the production of carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) by animals and by manure from pig buildings, with a focus on the influence of rearing techniques and nutrition. GHG emissions in piggeries originate from animals through CO2 exhalation and CH4 enteric fermentation, and from manure through the release of CO2, CH4 and N2O. The level of the CO2 exhalation (E-CO2, pig) depends on the physiological stage, the body weight (BW), the production level and the feed intake of the animals concerned. Enteric CH4 (E-CH4, pig) is principally related to dietary fibre intake and the fermentative capacity of the pig’s hindgut. Based on a review of the literature, the following equations are proposed in order to estimate E-CO2, pig (in kg day_1) and E-CH4,pig (in g day_1) for fattening pigs: E-CO2, pig = 0.136 _ BW0.573; E-CH4,pig = 0.012 _ dRes; with BW (in kg) and dRes for digestible residues (in g day_1). Numerous pathways are responsible for GHG production in manure. In addition, the microbial, physical and chemical properties of manure interact and modulate the level of emissions. Influencing factors for removal systems for both liquid and solid fractions of manure have been investigated. A large range of parameters showing an impact on the level of GHG production from pig houses has been reported. However, few of these can be considered unquestionably as GHG mitigation techniques because some strategies have shown contradictory effects depending on the gas, the circumstances and the study. Nevertheless, frequent manure removal seems to be an efficient means to reduce concurrently CO2-, CH4- and N2O-emissions from pig buildings for both slatted and bedded floor systems. Manure removal operations may be associated with specific storage conditions and efficient treatment in order to further reduce emissions. Several feeding strategies have been tested to decrease GHG emissions but they seem to be ineffective in reducing emissions both significantly and durably. In general, good management practices that enhance zootechnical performance will have beneficial consequences on GHG emission intensity. Taking into account the results described in the literature regarding CO2-, CH4- and N2O-production from animals and manure in pig houses, we estimate total GHG emissions to 448.3 kg CO2equiv. per slaughter pig produced or 4.87 kg CO2equiv. per kg carcass. The fattening period accounts for more than 70% of total emissions, while the gestation, lactation and weaning periods each contribute to about 10% of total emissions. Emissions of CO2, CH4 and N2O contribute to 81, 17 and 2% of total emissions from pig buildings, representing 3.87, 0.83 and 0.11 kg CO2equiv. per kg carcass, respectively. [less ▲]

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See detailNoncollinear magnetism in post-perovskites from first-principles: Comparison between CaRhO3 and NaNiF3
Garcia Castro, Andrés Camilo ULg; Romero, Aldo; Bousquet, Eric ULg

in Physica Status Solidi B. Basic Research (2015), 252(4), 689

Based on first-principles calculations, we study the noncollinear magnetism in the post-perovskites (pPv) phase of NaNiFinline image and CaRhOinline image crystals. We find that the magnetic canting is ... [more ▼]

Based on first-principles calculations, we study the noncollinear magnetism in the post-perovskites (pPv) phase of NaNiFinline image and CaRhOinline image crystals. We find that the magnetic canting is one of the most promising properties of pPv systems, which is allowed by symmetry in all the pPv crystals inline image with a magnetically active B-site. In the pPv phase of NaNiFinline image, which has a inline image antiferromagnetic ground state with a inline image ferromagnetic canting, we obtain a magnetic canting amplitude of about 0.1 inline imageatominline image, which is much larger than in the one obtained in CaRhOinline image (canting amplitude of 0.04 inline image). We also computed the exchange constants (inline image), the single-ion anisotropy (SIA) parameters and the anti-symmetric magnetic coupling described by the Dzyaloshinsky–Moriya (DM) interaction in order to scrutinize the origin of the magnetic canting. We find that the canting in NaNiFinline image is mainly due to the DM interaction, while in CaRhOinline image, both DM and SIA contribute to the magnetic canting. Our calculations thus confirm the noncollinear magnetic ground-state solution experimentally observed in both compounds and the calculated magnetic exchange interactions also confirm the quasi-2D magnetic behavior reported in pPv. [less ▲]

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See detailChemical composition and functional properties of dietary fibre extracted by Englyst and Prosky methods from the alga Ulva lactuca collected in Tunisia
Yaich, Hela; Garna, Haikel; Bchir, Brahim et al

in Algal Research (2015), 9

Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present ... [more ▼]

Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present investigation was firstly to compare two methods of dietary fibre quantification (Englyst and Prosky) and secondly to determine the chemical composition and some of the functional properties of total and insoluble fibres extracted in accordance with the Englyst method. The dietary fibres of dried Ulva lactuca collected from the Tunisian littoral were determined by the Prosky (gravimetric method) and Englyst (enzymatic-chemical method) methods. The two extraction methods (Englyst–Prosky) provided approximately the same values in total fibres (~54%). However, they had different insoluble and soluble fibre contents. U. lactuca contained 20.53% and 31.55% of soluble fibres and 34.37% and 21.54% of insoluble fibres using the Prosky and Englyst methods, respectively. The fractionation of the insoluble dietary fibre concentrate revealed that hemicellulose was the most abundant fraction (32.49%), followed by cellulose (16.59%) and “lignin-like” compounds (1.53%). For both fibre concentrates, the main neutral sugar was glucose (20.70%–27.59%), which corresponded to hemicellulose and cellulose. The water holding capacity of insoluble fibre concentrate was relatively high. It varied between 9.32 g and 10.3 g of water/g of dry fibre at 25 °C and 80 °C, respectively. Nevertheless, the oil holding capacity of the insoluble fibre concentrate was not affected by temperature. It was about 1.08 and 1.01 g of oil/g of dry fibre at 25 °C and 80 °C. Despite the significant functional properties of fibre concentrate, the presence of lead limits its use as an ingredient in the food industry. [less ▲]

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See detailElevated heart rate at 24-36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure.
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailFew remarks regarding some unnatural aquarium fish breeds and improper fish maintenance
Eşanu, Valentin O.; Gavriloaie, Claudiu; Oroian, Ian G. et al

in Aquaculture, Aquarium, Conservation & Legislation (2015), 8(2), 236-243

Ornamental fish were kept in captivity from ancient times. Gradually, the ornamental fish industry became a profitable enterprise. Color, size and shape are important traits when we describe a fish as a ... [more ▼]

Ornamental fish were kept in captivity from ancient times. Gradually, the ornamental fish industry became a profitable enterprise. Color, size and shape are important traits when we describe a fish as a phenotypically uniform line, strain or breed. Numerous varieties of aquarium fish have been artificially modified regarding their body shape or coloration. Several varieties of fish are being artificially colored by painting and tattooing to improve their marketability. All these practices cause many health problems for fish. Education of the customers is a very important thing, because artificially modified fish continue to exist because of demand. [less ▲]

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See detailEfficient 3D transfer operators based on numerical integration
Bussetta, Philippe ULg; Boman, Romain ULg; Ponthot, Jean-Philippe ULg

in International Journal for Numerical Methods in Engineering (2015), 102(3-4), 892-929

This paper deals with data transfer between two meshes as it happens in a finite element context when a remeshing has to be performed. We propose a finite-volume-based data transfer method for an ... [more ▼]

This paper deals with data transfer between two meshes as it happens in a finite element context when a remeshing has to be performed. We propose a finite-volume-based data transfer method for an efficient remeshing of three-dimensional solid mechanics problems. The originality of this transfer method stems from a linear reconstruction of the fields to be transferred on an auxiliary finite volume mesh, a fast computation of the transfer operator and the application to the complete remeshing of 3D problems. This procedure is applicable to both nodal values and discrete fields defined at quadrature points. In addition, a data transfer method using mortar elements is presented. The main improvement made to this second method comes from a fast computation of mortar elements. These two data transfer methods are compared with the simplest transfer method, which consists of a classical interpolation. After some academic examples, we present 2D forging and 3D friction stir welding applications. [less ▲]

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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Lecture notes on Mobility (2015)

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See detailAdded value of a triaxial accelerometer assessing gait parameters to predict falls and mortality among nursing home residents: A two-year prospective study.
Buckinx, Fanny ULg; Beaudart, Charlotte ULg; Slomian, Justine ULg et al

in Technology and health care : official journal of the European Society for Engineering and Medicine (2015), 23

BACKGROUND: Gait impairment seems to be a risk factor for falls and mortality. Because gait change cannot be determined easily with classical clinical tests, some authors have suggested that it might be ... [more ▼]

BACKGROUND: Gait impairment seems to be a risk factor for falls and mortality. Because gait change cannot be determined easily with classical clinical tests, some authors have suggested that it might be useful to use a gait-analysis system among elderly community-dwelling people. OBJECTIVE: The main objective of the present study was to determine the predictive value of a quantitative evaluation of the gait characteristics in nursing home residents for the occurrence of falls and death performed using a tri-axial accelerometer (Locometrix(R)). MATERIAL AND METHODS: One hundred elderly nursing home residents (80 women and 20 men, mean age 86.4 +/- 6.04 years) were included in this study with the aim to follow them for 2 years. Deaths and falls were systematically recorded. A quantitative evaluation of a 10-second walk was performed with a tri-axial accelerometer (Locometrix(R)). Demographic data (i.e age, sex, body mass index) and clinical data (i.e. fall risk evaluated by the Tinetti test) were also recorded. RESULTS: During the two years of follow-up, 27 patients died. After adjustment on all potential confounding variables, only body mass index was significantly associated with the risk of mortality with an odds ratio of 0.86 (95% CI: 0.77-0.96, p=0.04). At the end of the study period, 440 falls had occurred (mean: 4.44 +/- 6.79 falls per patient) but no single factors were independently associated with fall incidence. CONCLUSION: Our results show that a quantitative gait analysis performed using a tri-axial accelerometer is not predictive of long-term falls and mortality among nursing home residents. [less ▲]

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See detailNeuromodulation in cluster headache.
Fontaine, Denys; Vandersteen, Clair; MAGIS, Delphine ULg et al

in Advances and technical standards in neurosurgery (2015), 42

Medically refractory chronic cluster headache (CH) is a severely disabling headache condition for which several surgical procedures have been proposed as a prophylactic treatment. None of them have been ... [more ▼]

Medically refractory chronic cluster headache (CH) is a severely disabling headache condition for which several surgical procedures have been proposed as a prophylactic treatment. None of them have been evaluated in controlled conditions, only open studies and case series being available. Destructive procedures (radiofrequency lesioning, radiosurgery, section) and microvascular decompression of the trigeminal nerve or the sphenopalatine ganglion (SPG) have induced short-term improvement which did not maintain on long term in most of the patients. They carried a high risk of complications, including severe sensory loss and neuropathic pain, and consequently should not be proposed in first intention.Deep brain stimulation (DBS), targeting the presumed CH generator in the retro-hypothalamic region or fibers connecting it, decreased the attack frequency >50 in 60 % of the 52 patients reported. Complications were infrequent: gaze disturbances, autonomic disturbances, and intracranial hemorrhage (2).Occipital nerve stimulation (ONS) was efficient (decrease of attack frequency >50 %) in about 70 % of the 60 patients reported, with a low risk of complications (essentially hardware related). Considering their respective risks, ONS should be proposed first and DBS only in case of ONS failure.New on-demand chronically implanted SPG stimulation seemed to be efficient to abort CH attacks in a pilot controlled trial, but its long-term safety needs to be further studied. [less ▲]

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See detailAlgebrability and nowhere Gevrey differentiability
Bastin, Françoise ULg; Conejero, J. Alberto; Esser, Céline ULg et al

in Israel Journal of Mathematics (2015), 205

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and ... [more ▼]

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and, therefore, lineability) of functions enjoying this property. In the process of proving these results we also provide a new construction of nowhere Gevrey di fferentiable functions. [less ▲]

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See detailComplementary approaches for the numerical simulation of the Micro- Plasto-Hydrodynamic Lubrication regime
Hubert, Cédric; Dubois, André; Dubar, Laurent et al

in Key Engineering Materials [=KEM] (2015), 651-653

This paper presents recent investigations in the field of lubricant escapes from asperities. This phenomenon, named Micro Plasto Hydrodynamic Lubrication (MPHL), induces friction variation during metal ... [more ▼]

This paper presents recent investigations in the field of lubricant escapes from asperities. This phenomenon, named Micro Plasto Hydrodynamic Lubrication (MPHL), induces friction variation during metal forming processes. A better understanding of MPH lubrication would lead to a better management of friction, which is a central element in most sheet metal forming processes. To fulfil that goal, experiments were conducted in plane strip drawing using a transparent upper tool in order to observe lubricant flow around macroscopic pyramidal cavities. These experiments were then numerically reproduced with two complementary Finite Element models. The numerical results are discussed in this paper and show good agreement with experimental measurements. [less ▲]

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See detailAn engine for global plant diversity: highest evolutionary turnover and emigration in the American tropics
Antonelli, Alexandre; Zizka, Alexander; Silvestro, Daniele et al

in Frontiers in Genetics (2015), 6

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See detailGenome-wide transcriptional analysis suggests hydrogenase- and nitrogenase-mediated hydrogen production in Clostridium butyricum CWBI 1009
Calusinska, Magda; Hamilton, Christopher; Monsieurs, Pieter et al

in Biotechnology for Biofuels (2015), 8(27), 1-16

Background: Molecular hydrogen, given its pollution-free combustion, has great potential to replace fossil fuels in future transportation and energy production. However, current industrial hydrogen ... [more ▼]

Background: Molecular hydrogen, given its pollution-free combustion, has great potential to replace fossil fuels in future transportation and energy production. However, current industrial hydrogen production processes, such as steam reforming of methane, contribute significantly to the greenhouse effect. Therefore alternative methods, in particular the use of fermentative microorganisms, have attracted scientific interest in recent years. However the low overall yield obtained is a major challenge in biological H2 production. Thus, a thorough and detailed understanding of the relationships between genome content, gene expression patterns, pathway utilisation and metabolite synthesis is required to optimise the yield of biohydrogen production pathways. Results: In this study transcriptomic and proteomic analyses of the hydrogen-producing bacterium Clostridium butyricum CWBI 1009 were carried out to provide a biomolecular overview of the changes that occur when the metabolism shifts to H2 production. The growth, H2-production, and glucose-fermentation profiles were monitored in 20 L batch bioreactors under unregulated-pH and fixed-pH conditions (pH 7.3 and 5.2). Conspicuous differences were observed in the bioreactor performances and cellular metabolisms for all the tested metabolites, and they were pH dependent. During unregulated-pH glucose fermentation increased H2 production was associated with concurrent strong up-regulation of the nitrogenase coding genes. However, no such concurrent up-regulation of the [FeFe] hydrogenase genes was observed. During the fixed pH 5.2 fermentation, by contrast, the expression levels for the [FeFe] hydrogenase coding genes were higher than during the unregulated-pH fermentation, while the nitrogenase transcripts were less abundant. The overall results suggest, for the first time, that environmental factors may determine whether H2 production in C. butyricum CWBI 1009 is mediated by the hydrogenases and/or the nitrogenase. Conclusions: This work, contributing to the field of dark fermentative hydrogen production, provides a multidisciplinary approach for the investigation of the processes involved in the molecular H2 metabolism of clostridia. In addition, it lays the groundwork for further optimisation of biohydrogen production pathways based on genetic engineering techniques. [less ▲]

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See detailBespreking Hof van Justitie 3 oktober 2013
Peeters, Bart ULg

in Rechtskundig Weekblad (2015), 2014-2015

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See detailIs the Sørensen test valid to assess muscle fatigue of the trunk extensor muscles?
Demoulin, Christophe ULg; Boyer, Mathieu; Duchateau, Jacques et al

in Journal of Back and Musculoskeletal Rehabilitation (2015), 00

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen ... [more ▼]

BACKGROUND: Very few studies have quantified the degree of fatigue characterized by the decline in the maximal voluntary contraction (MVC) force of the trunk extensors induced by the widely used Sørensen test. OBJECTIVE: Measure the degree of fatigue of the trunk extensor muscles induced by the Sørensen test. METHODS: Eighty young healthy subjects were randomly divided into a control group (CG) and an experimental group (EG), each including 50% of the two genders. The EG performed an isometric MVC of the trunk extensors (pre-fatigue test) followed by the Sørensen test, the latter being immediately followed by another MVC (post-fatigue test). The CG performed only the preand post-fatigue tests without any exertion in between. RESULTS: The comparison of the pre- and post-fatigue tests revealed a significant (P <0.05) decrease in MVC force normalized by body mass (−13%) in the EG, whereas a small increase occurred in the CG (+2.7%, P = 0.001). CONCLUSIONS: This study shows that the Sørensen test performed until failure in a young healthy population results in a reduced ability of the trunk extensor muscles to generate maximal force, and indicates that this test is valid for the assessment of fatigue in trunk extensor muscles. [less ▲]

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See detailMicrowave-assisted thermochemical and primary hydrolytic conversions of lignocellulosic resources: a review
Richel, Aurore ULg; Jacquet, Nicolas ULg

in Biomass Conversion and Biorefinery (2015), 5(1), 115-124

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has ... [more ▼]

Faced with the inevitable depletion of fossil resources, agricultural productions have rapidly emerged as promising renewable alternatives. Particularly, the conversion of lignocellulosic materials has nowadays opened new vistas for the production of energy, biofuels and chemicals. In this literature review, microwave technology is described as an original heating source either for the thermochemical conversions (at temperatures up to 400°C) of lignocellulose into biofuels or the pretreatment (below 400°C) and further hydrolysis of lignocellulose into bioethanol and other valuable chemicals. Advantages of microwave approaches include a commonly observed acceleration in reaction rate and improved selectivities and yields. [less ▲]

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See detailLe regard (peu optimiste) du soignant sur la personne âgée
Schroyen, Sarah ULg; Missotten, Pierre ULg; Marquet, Manon ULg et al

in Medi-Sphere (2015), 469

L’âgisme (c’est-à-dire l’ensemble de nos stéréotypes liés à l’avancée en âge) a de nombreuses conséquences négatives tant pour le patient lui-même qu’au sein de la relation entre le patient et le ... [more ▼]

L’âgisme (c’est-à-dire l’ensemble de nos stéréotypes liés à l’avancée en âge) a de nombreuses conséquences négatives tant pour le patient lui-même qu’au sein de la relation entre le patient et le personnel soignant. Au cours de cet article, nous illustrerons les représentations du vieillissement prévalentes chez les soignants et aborderons brièvement les conséquences de l’âgisme sur leurs attitudes de soins. [less ▲]

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See detailFramework for the integration of genomics, epigenomics, and transcriptomics in complex diseases
Pineda San Juan, Silvia ULg; Gómez-Rubio, Paulina; Antoni, Picornell et al

in Human Heredity (2015)

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See detailTagging with leisure needs
Pestieau, Pierre ULg; Racionero, Maria

in Social Choice and Welfare (2015)

We study optimal redistributive taxes when individuals differ in two characteristics—earning ability and leisure needs—assumed to be imperfectly correlated. Individuals have private information about ... [more ▼]

We study optimal redistributive taxes when individuals differ in two characteristics—earning ability and leisure needs—assumed to be imperfectly correlated. Individuals have private information about their abilities but needs are observable. With different levels of observable needs the population can be separated into groups and needs may be used as a tag.We first assume that the social planner considers individuals should be compensated for their leisure needs and characterize the optimal redistributive policy, and the extent of compensation for needs, with tagging.We also consider an alternative social objective where individuals are deemed responsible for their needs. [less ▲]

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See detailL’acte incendiaire, son sujet et sa signification : propositions à partir du Saint Genet de Jean-Paul Sartre
Englebert, Jérôme ULg

in Annales Médico-Psychologiques (2015), 172(2), 186-192

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the ... [more ▼]

Objectives In this paper we studied fire setters with the hermeneutics’ method from the philosophy of Jean-Paul Sartre. In the psychobiography of Jean Genet, the philosopher raises issues of the infractional acting and its social meaning. Methods After recalling the basic notions of international literature about fire setters (including confusion with pyromania, diagnostic problems proposed by the DSM IV and the concept of "communicative arson"), we propose phenomenological and existential clues to discuss the act and its meaning. It is the unlawful act that is analysed and more specifically the arson. We propose different analysis than the psychic causality which is inspired by psychoanalysis. The criminogenesis gives way to a questioning of identity, about the place of fire in the subject’s history and within its relationships to others. As proposed by Sartre, the paradigm of this research is to consider the meaning "as the return of the future in the present". The second field of this study is an analysis of three clinical cases. These cases are the result of a forensic practice. The method is focused on the analysis of a narrative and autobiographical production. By this way we studied the temporal process of these three arsonists. Results A comparative reading of the psychobiography of Jean Genet written by Sartre and of the situation of arsonists gives accurate information. The "criminogenesis" gives way to a questioning of identity. In this way we discuss the meaning of fire in the subject's history and within its relationship to others. We highlight the inscription of the act in the social and constitutive process of the individual. From the clinical material, the author demonstrates a link between arson and construction of identity. Identity is considered as a dialectic between “ipse” and “idem”, as suggested by Ricœur. We can therefore consider the real sense that the arson has from the perspective of the actor but also from the viewpoint of the society and these conceptions may be similar or different. In clinical practice, we recommend to pay special attention to how the fire is part of the biography of the patient. Conclusions The fascination for fire is a source of meaning which can be radically different depending on whether we consider the external interpreter (the world or the clinician) or the author of the action. The basic principles of hermeneutics, as described by Gadamer and Ricœur, are to demonstrate that the understanding and the interpretation are not only the methods used in the human sciences but are also part of the fundamental processes inherent in human nature. Hermeneutics in general is the opposite of a doctrine of truth. It rather seeks to show arbitrarily how the interpretation and the search for meaning are paradigmatic of the human experience. [less ▲]

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See detailUncertainties in Models of Stellar Structure and Evolution
Noels-Grötsch, Arlette ULg; Bragaglia, Angela

in Astrophysics and Space Science Proceedings (2015), 39

Numerous physical aspects of stellar physics have been presented in Session 2 and the underlying uncertainties have been tentatively assessed. We try here to highlight some specific points raised after ... [more ▼]

Numerous physical aspects of stellar physics have been presented in Session 2 and the underlying uncertainties have been tentatively assessed. We try here to highlight some specific points raised after the talks and during the general discussion at the end of the session and eventually at the end of the workshop. A table of model uncertainties is then drawn with the help of the participants in order to give the state of the art in stellar modeling uncertainties as of July 2013. [less ▲]

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See detailActive faulting at the western tip of the Gulf of Corinth, Greece, from high-resolution seismic data
Beckers, Arnaud ULg; Hubert, Aurelia ULg; Beck, Christian et al

in Marine Geology (2015)

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to ... [more ▼]

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to 16 mm yr-1 in its westernmost part. Although the rest of the offshore rift has been well studied, the western tip of the rift is still poorly explored. We present an accurate map of submarine faults in this area based on two high-resolution seismic reflection surveys (single channel sparker). In the eastern part of the studied area, the sedimentary infill is affected by the known North Eratini, South Eratini and West Channel faults. Further to the west, the seafloor is mostly flat, and is bounded to the north by the normal, south-dipping, Trizonia fault. To the north, the shallower part of the Gulf shows to the east a diffuse pattern of normal and strike-slip deformation which is replaced to the west by a 7.5 km long SE striking strike-slip fault zone, called the Managouli fault zone. To the westernmost tip of the Gulf, in the Nafpaktos Basin, two fault sets with different strikes are encountered; the one with aNE-SW strike exhibits a clear strike-slip component. The western tip of the Gulf of Corinth is the only part of the Corinth Rift where convincing evidence for strike-slip movement has been found. This fault pattern is likely related to the complex deformation occurring at the diffuse junction at the western tip of the Rift between three crustal blocks: Continental Greece, Peloponnese, and the Ionian Island-Akarnia block. [less ▲]

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See detailSmall Angle X-ray Scattering Insights into the Architecture-Dependent Emulsifying Properties of Amphiphilic Copolymers in Supercritical Carbon Dioxide
Alaimo, David ULg; Hermida Merino, Daniel; Grignard, Bruno ULg et al

in Journal of Physical Chemistry B (2015), 119

The supramolecular assembly of a series of copolymers combining a PEO-rich hydrophilic and fluorinated CO2-philic sequences is analysed by synchrotron small-angle xray scattering (SAXS) in supercritical ... [more ▼]

The supramolecular assembly of a series of copolymers combining a PEO-rich hydrophilic and fluorinated CO2-philic sequences is analysed by synchrotron small-angle xray scattering (SAXS) in supercritical CO2, as well as in water/CO2 emulsions. These copolymers were designed to have the same molecular weight and composition, and to differ only by their macromolecular architecture. The investigated copolymers have random, block, and palm-tree architectures. Besides, thermo-responsive copolymer is also analysed, having a hydrophilic sequence becoming water-insoluble around 41 °C, i.e. just above the critical point of CO2. At the length scale investigated by SAXS, only the random copolymer appears to self-assemble in pure CO2, in the form of a disordered microgel-like network. The random, block and thermo-responsive copolymers are all able to stabilize water/CO2 emulsions but not the copolymer with the palm-tree architecture, pointing at the importance of macromolecular architecture for the emulsifying properties. A modelling of the SAXS data shows that the block and the thermo-responsive copolymers form spherical micelle-like structures containing about 70 % water and 30 % polymer. [less ▲]

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See detailRituximab therapy for hairy cell leukemia : a retrospective study of 41 cases
Leclerc, Mathieu; Suarez, Felipe; Noël, Marie-Pierre et al

in Annals of Hematology (2015), 94

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and ... [more ▼]

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 centers in France and Belgium, who received 49 treatment courses with the anti-CD20 monoclonal antibody rituximab. Most of the patients were treated at relapse (84 % of cases) and rituximab was combined to a PA in 41 % of cases. Overall, response rate is 90 % including 71 % complete hematologic responses (CHRs). Frontline treatment, combination therapy, and absolute neutrophil count were associated with response in multivariate analysis. Three-year relapse-free and overall survivals are 68 and 90 %, respectively. When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy. In contrast, response rate is only 82 % (59 % CHR) when rituximab is used alone. In this latter setting, relapse rate is 56 % and median time to relapse is 17.5 months. All eight patients who were treated two times with the antibody responded again to retreatment. We confirm the high efficacy of the combination rituximab + PA. However, when rituximab is used as monotherapy, response rate is lower and the high relapse rate is a concern. Prospective clinical trials are needed to confirm the superiority of the combination rituximab + PA over PA alone, both as frontline therapy and at relapse. [less ▲]

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See detailA 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density: Results From the ADAMO Trial.
Langdahl, Bente L.; Teglbjaerg, Christence S.; Ho, Pei-Ran et al

in The Journal of clinical endocrinology and metabolism (2015), 100(4), 1335-1342

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men ... [more ▼]

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men with low BMD. Design: Phase 3 study with two treatment periods: a previously reported 12-month double-blind, placebo-controlled phase and a 12-month open-label phase. Setting: Multicenter in North America and Europe. Participants: 228 men entered the open-label phase and 219 completed the study. Intervention: Men from the original denosumab (long-term) and placebo (crossover) groups received denosumab 60 mg SC every 6 months. Main Outcome Measures: BMD, serum C-telopeptide (sCTX), and safety. Results: During the open-label phase, continued BMD increases occurred with long-term denosumab treatment (2.2% lumbar spine; 0.9% total hip; 1.3% femoral neck; 1.3% trochanter; and 0.2% 1/3 radius), resulting in cumulative 24-month gains from baseline of 8.0%, 3.4%, 3.4%, 4.6%, and 0.7%, respectively (all P<0.01). The crossover group showed BMD gains after 12 months of denosumab treatment similar to the long-term denosumab group during the first treatment year. Significant reductions in sCTX were observed following denosumab administration. Adverse events rates were similar between groups and no new safety signals identified. Conclusions: In men with low BMD, denosumab treatment for a second year continued to increase BMD, maintained reductions in bone resorption, and was well tolerated. BMD increased in men initiating denosumab during the second year. These effects were similar to those previously seen in postmenopausal women with osteoporosis and men with prostate cancer on androgen deprivation therapy. [less ▲]

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See detailThe clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF).
Cianferotti, Luisella; Cricelli, Claudio; Kanis, John A. et al

in Endocrine (2015)

Several compounds are produced along the complex pathways of vitamin D3 metabolism, and synthetic analogs have been generated to improve kinetics and/or vitamin D receptor activation. These metabolites ... [more ▼]

Several compounds are produced along the complex pathways of vitamin D3 metabolism, and synthetic analogs have been generated to improve kinetics and/or vitamin D receptor activation. These metabolites display different chemical properties with respect to the parental or native vitamin D3, i.e., cholecalciferol, which has been, so far, the supplement most employed in the treatment of vitamin D inadequacy. Hydrophilic properties of vitamin D3 derivatives facilitate their intestinal absorption and their manageability in the case of intoxication because of the shorter half-life. Calcidiol is a more hydrophilic compound than parental vitamin D3. Active vitamin D analogs, capable of binding the vitamin D receptor evoking vitamin D-related biological effects, are mandatorily employed in hypoparathyroidism and kidney failure with impaired 1alpha-hydroxylation. They have been shown to increase BMD, supposedly ameliorating calcium absorption and/or directly affecting bone cells, although their use in these conditions is jeopardized by the development of hypercalciuria and mild hypercalcemia. Further studies are needed to assess their overall safety and effectiveness in the long-term and new intermittent regimens, especially when combined with the most effective antifracture agents. [less ▲]

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See detailL’innovation et ses territoires
Merenne-Schoumaker, Bernadette ULg

in Cahiers d'Economie et Gestion (2015), Mars-Mai

Analysis of innovation at three spatial scales: the world, countries and regional and local areas. Observation of the predominance of a center-periphery model

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See detailMerging multi-camera data to reduce motion analysis instrumental errors using Kalman filters
Schwartz, Cédric ULg; Denoël, Vincent ULg; Forthomme, Bénédicte ULg et al

in Computer Methods in Biomechanics and Biomedical Engineering (2015), 18(9), 952-960

In motion capture systems, markers are often seen by multiple cameras. All cameras do not measure the position of the markers with the same reliability because of environmental factors such as the ... [more ▼]

In motion capture systems, markers are often seen by multiple cameras. All cameras do not measure the position of the markers with the same reliability because of environmental factors such as the position of the marker in the field of view or the light intensity received by the cameras. Kalman filters offer a general framework to take the reliability of the various cameras into account and consequently improve the estimation of the marker position. The proposed process can be applied to both passive and active systems. Several reliability models of the cameras are compared for the Codamotion active system, which is considered as a specific illustration. The proposed method significantly reduces the noise in the signal, especially at long range distances. Therefore, it improves the confidence of the positions at the limits of the field of view. [less ▲]

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See detailUnited but (un)equal: human capital, probability of divorce, and the marriage contract
Cremer, Helmuh; Pestieau, Pierre ULg; Roeder, Kerstin

in Journal of Population Economics (2015), 28

This paper studies how the risk of divorce affects the human capital decisions of a young couple. We consider a setting where complete specialization is optimal with no divorce risk. Couples can self ... [more ▼]

This paper studies how the risk of divorce affects the human capital decisions of a young couple. We consider a setting where complete specialization is optimal with no divorce risk. Couples can self-insure through savings which offers some protection to the uneducated spouse, but at the expense of a distortion. Alternatively, for large divorce probabilities, symmetry in education, where both spouses receive an equal amount of education, may be optimal. This eliminates the risk associated with the lack of education, but reduces the efficiency of education choices. We show that the symmetric allocation will become more attractive as the probability of divorce increases, if risk aversion is high and/or labor supply elasticity is low. However, it is only a “second-best” solution as insurance protection is achieved at the expense of an efficiency loss. Finally, we study how the (economic) use of marriage is affected by the possibility of divorce. [less ▲]

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See detailReversing song behavior phenotype: Testosterone driven induction of singing and measures of song quality in adult male and female canaries (Serinus canaria)
Madison, Farrah N.; Rouse, Melvin L. Jr; Balthazart, Jacques ULg et al

in General and comparative endocrinology (2015), 215

In songbirds, such as canaries (Serinus canaria), the song control circuit has been shown to undergo a remarkable change in morphology in response to exogenous testosterone (T). It is also well ... [more ▼]

In songbirds, such as canaries (Serinus canaria), the song control circuit has been shown to undergo a remarkable change in morphology in response to exogenous testosterone (T). It is also well established that HVC, a telencephalic nucleus involved in song production, is significantly larger in males than in females. T regulates seasonal changes in HVC volume in males, and exposure to exogenous T in adult females increases HVC volume and singing activity such that their song becomes more male-like in frequency and structure. However, whether there are sex differences in the ability of T to modulate changes in the song system and song behavior has not been investigated in canaries. In this study, we compared the effects of increasing doses of T on singing and song control nuclei volumes in adult male and female American Singer canaries exposed to identical environmental conditions. Males were castrated and all birds were placed on short days (8L:16D) for 8weeks. Males and females were implanted either with a 2, 6 or 12mm long Silastic implant filled with crystalline T or an empty 12mm implant as control. Birds were then housed individually in sound-attenuated chambers. Brains were collected from six birds from each group after 1week or 3weeks of treatment. Testosterone was not equally effective in increasing singing activity in both males and females. Changes in song quality and occurrence rate took place after a shorter latency in males than in females; however, females did undergo marked changes in a number of measures of song behavior if given sufficient time. Males responded with an increase in HVC volume at all three doses. In females, T-induced changes in HVC volume only had limited amplitude and these volumes never reached male-typical levels, suggesting that there are sex differences in the neural substrate that responds to T. [less ▲]

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See detailFluid fragmentation shapes rain-induced foliar disease transmission
Gilet, Tristan ULg; Bourouiba, Lydia

in Journal of the Royal Society, Interface (2015), 12

Plant diseases represent a growing threat to the global food supply. The factors contributing to pathogen transmission from plant to plant remain poorly understood. Statistical correlations between ... [more ▼]

Plant diseases represent a growing threat to the global food supply. The factors contributing to pathogen transmission from plant to plant remain poorly understood. Statistical correlations between rainfalls and plant disease out- breaks were reported; however, the detailed mechanisms linking the two were relegated to a black box. In this combined experimental and theoretical study, we focus on the impact dynamics of raindrops on infected leaves, one drop at a time. We find that the deposition range of most of the pathogen-bear- ing droplets is constrained by a hydrodynamical condition and we quantify the effect of leaf size and compliance on such constraint. Moreover, we identify and characterize two dominant fluid fragmentation scenarios as responsible for the dispersal of most pathogen-bearing droplets emitted from infected leaves: (i) the crescent-moon ejection is driven by the direct interaction between the impacting raindrop and the contaminated sessile drop and (ii) the inertial detachment is driven by the motion imparted to the leaf by the raindrop, lead- ing to catapult-like droplet ejections. We find that at first, decreasing leaf size or increasing compliance reduces the range of pathogen-bearing droplets and the subsequent epidemic onset efficiency. However, this conclusion only applies for the crescent moon ejection. Above a certain compliance threshold a more effective mechanism of contaminated fluid ejection, the inertial detachment, emerges. This compliance threshold is determined by the ratio between the leaf velocity and the characteristic velocity of fluid fragmentation. The inertial detachment mechanism enhances the range of deposition of the larger con- taminated droplets and suggests a change in epidemic onset pattern and a more efficient potential of infection of neighbouring plants. Dimensionless parameters and scaling laws are provided to rationalize our observations. Our results link for the first time the mechanical properties of foliage with the onset dynamics of foliar epidemics through the lens of fluid fragmentation. We discuss how the reported findings can inform the design of mitigation strategies acting at the early stage of a foliar disease outbreak. [less ▲]

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See detailChemostratigraphy of the late devonian Frasnian-Famennian transition in western Canada and Southern China: implications for carbon and nutrient cycling and mass extinction
Whalen; Sliwinski; Payne et al

in Special Publication - Geological Society of London (2015), 414

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See detailEACVI/HFA Cardiac Oncology Toxicity Registry in breast cancer patients: rationale, study design, and methodology (EACVI/HFA COT Registry)-EURObservational Research Program of the European Society of Cardiology.
Lancellotti, Patrizio ULg; Anker, Stefan D.; Donal, Erwan et al

in European heart journal cardiovascular Imaging (2015)

The goal of adjuvant anti-cancer therapies is cure with limited or no side effects, in particular long-term side effects with negative impact on quality of life. In the palliative setting disease control ... [more ▼]

The goal of adjuvant anti-cancer therapies is cure with limited or no side effects, in particular long-term side effects with negative impact on quality of life. In the palliative setting disease control, quality of life and overall survival are important end points. Partly due to improvements in treatment, the population of cancer survivors is large and growing. However, anti-cancer drug-related cardiotoxicity (ADRC) is the leading cause of treatment-associated mortality in cancer survivors. It is one of the most common post-treatment problems among 5- to 10-year survivors of adult cancer. This is particularly true for breast cancer, the most common cancer in women. The EACVI/HFA COT registry is designed for comprehensive data collection and evaluation of the current European practice in terms of diagnosis and management of ADRC in breast cancer patients. The COT registry will be carried out in two continuing phases, the pilot study phase involving 13 countries followed by the long-term registry in which all the 56 ESC countries will be invited to participate. With the COT registry, several critical information will be obtained: on predisposing factors for the development of ADRC, the rate of subclinical LV dysfunction and its transition to overt heart failure, the clinical impact and outcome of ADRC. [less ▲]

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See detailThe neural basis of temporal order processing in past and future thought
D'Argembeau, Arnaud ULg; Jeunehomme, Olivier ULg; Majerus, Steve ULg et al

in Journal of Cognitive Neuroscience (2015), 27

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See detailIntegrating hydrological features and 1 genetically validated occurrence data in occupancy 2 modeling of an endemic and endangered semi‐aquatic mammal species, Galemys pyrenaicus. 3 4
Charbonnel, Anaïs; Buisson, Laetitia; Biffi, Marjorie et al

in Biological Conservation (2015), Sous Presse

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See detailPostcolonial Thesholds: Gateways and Borders
Wilson, Janet; Tunca, Daria ULg

in Journal of Postcolonial Writing (2015), 51(1), 1-107

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See detailReply: valvular disease, myocardial mechanics, and valve guidelines.
Donal, Erwan; Lancellotti, Patrizio ULg; Sengupta, Partho P. et al

in JACC. Cardiovascular imaging (2015), 8(3), 383

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See detailExploring the major depletions of conodont diversity during the Triassic
Martínez-Pérez, Carlos; Cascales - Miñana, Borja ULg; Plasencia, Pablo et al

in Historical Biology (2015), 27(5), 503-507

In this paper, we show that the Triassic fossil record reflects just two great depletions of conodont diversity before the Rhaetian, which occurred in the Smithian (Olenekian, Early Triassic) and in the ... [more ▼]

In this paper, we show that the Triassic fossil record reflects just two great depletions of conodont diversity before the Rhaetian, which occurred in the Smithian (Olenekian, Early Triassic) and in the Julian (Carnian, Late Triassic). By exploring this context, our results highlighted that they respond to different origination-extinction dynamics. Thus, while the Smithian diversity depletion can be interpreted as a consequence of elevated extinction, the Julian diversity depletion was triggered by fluctuations in origination regime. This evidence suggests that, despite the role of extinction on diversity losses, conodonts suffered crucial changes on the origination regimes during the Late Triassic which triggered these events. Notwithstanding, our results indicate that the end-Triassic diversity depletion of conodonts was produced by background extinction levels in a context of lower origination. This suggests that several biological factors, rather than a unique, environmental and/or cyclic cause, could have influenced the evolutionary history of conodonts during the Triassic. © 2014 © 2014 Taylor & Francis. [less ▲]

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See detailRole of multimodality cardiac imaging in the management of patients with hypertrophic cardiomyopathy: an expert consensus of the European Association of Cardiovascular Imaging Endorsed by the Saudi Heart Association.
Cardim, Nuno; Galderisi, Maurizio; Edvardsen, Thor et al

in European heart journal cardiovascular Imaging (2015)

Taking into account the complexity and limitations of clinical assessment in hypertrophic cardiomyopathy (HCM), imaging techniques play an essential role in the evaluation of patients with this disease ... [more ▼]

Taking into account the complexity and limitations of clinical assessment in hypertrophic cardiomyopathy (HCM), imaging techniques play an essential role in the evaluation of patients with this disease. Thus, in HCM patients, imaging provides solutions for most clinical needs, from diagnosis to prognosis and risk stratification, from anatomical and functional assessment to ischaemia detection, from metabolic evaluation to monitoring of treatment modalities, from staging and clinical profiles to follow-up, and from family screening and preclinical diagnosis to differential diagnosis. Accordingly, a multimodality imaging (MMI) approach (including echocardiography, cardiac magnetic resonance, cardiac computed tomography, and cardiac nuclear imaging) is encouraged in the assessment of these patients. The choice of which technique to use should be based on a broad perspective and expert knowledge of what each technique has to offer, including its specific advantages and disadvantages. Experts in different imaging techniques should collaborate and the different methods should be seen as complementary, not as competitors. Each test must be selected in an integrated and rational way in order to provide clear answers to specific clinical questions and problems, trying to avoid redundant and duplicated information, taking into account its availability, benefits, risks, and cost. [less ▲]

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See detailDiabètes iatrogènes : importance d’une analyse critique du rapport bénéfices/risques des traitements en cause
SCHEEN, André ULg

in Médecine des Maladies Métaboliques (2015), 9(3), 1-3

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See detailCombining tree-based and dynamical systems for the inference of gene regulatory networks
Huynh-Thu, Vân Anh ULg; Sanguinetti, Guido

in Bioinformatics (2015), 31(10), 1614-1622

Motivation: Reconstructing the topology of gene regulatory networks (GRNs) from time series of gene expression data remains an important open problem in computational systems biology. Existing GRN ... [more ▼]

Motivation: Reconstructing the topology of gene regulatory networks (GRNs) from time series of gene expression data remains an important open problem in computational systems biology. Existing GRN inference algorithms face one of two limitations: model-free methods are scalable but suffer from a lack of interpretability and cannot in general be used for out of sample predictions. On the other hand, model-based methods focus on identifying a dynamical model of the system. These are clearly interpretable and can be used for predictions; however, they rely on strong assumptions and are typically very demanding computationally. Results: Here, we propose a new hybrid approach for GRN inference, called Jump3, exploiting time series of expression data. Jump3 is based on a formal on/off model of gene expression but uses a non-parametric procedure based on decision trees (called "jump trees") to reconstruct the GRN topology, allowing the inference of networks of hundreds of genes. We show the good performance of Jump3 on in silico and synthetic networks and applied the approach to identify regulatory interactions activated in the presence of interferon gamma. Availability and implementation: Our MATLAB implementation of Jump3 is available at http:// homepages.inf.ed.ac.uk/vhuynht/software.html. [less ▲]

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See detailLinear and nonlinear optical properties of functionalized CdSe quantum dots prepared by plasma sputtering and wet chemistry
Humbert, Christophe; Dahi, Abdellatif; Dalstein, Laetitia et al

in Journal of Colloid & Interface Science (2015), 445

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See detailShort communication: Novel method to predict body weight of primiparous dairy cows throughout the lactation
Vanrobays, Marie-Laure ULg; Vandenplas, Jérémie ULg; Hammami, Hedi ULg et al

in Journal of Dairy Science (2015), 98

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the ... [more ▼]

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the lactation would be useful, e.g., at milk-recording dates allowing feed-intake prediction for advisory purposes. Therefore, a 2-step approach was developed to obtain PBW for each milk-recording date. In the first step, a random-regression test-day model was used with CBW as observations to predict PBW. The second step consisted in changing means and (co)variances of prior distributions for the additive genetic random effects of the test-day model by using priors derived from results of the first step to predict again PBW. A total of 25,061 CBW from 24,919 primiparous Holstein cows were computed using equations from literature. Using CBW as observations, PBW was then predicted over the whole lactation for 232,436 dates corresponding to 207,375 milk-recording dates and 25,061 classification dates. Results showed that using both steps (the 2-step approach) provided more accurate predictions than using only the first step (the one-step approach). Based on the results of this preliminary study, BW of dairy cows could be predicted throughout the lactation using this procedure. These predictions could be useful in milk-recording systems to compute traits of interest (e.g., feed-intake prediction). The developed novel method is also flexible because actual direct measurements of BW can also be used together with CBW, the prediction model being able to accommodate different levels of accuracies of used BW phenotypes. [less ▲]

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See detailZebrafish bone and general physiology are differently affected by hormones or changes in gravity.
Aceto, Jessica ULg; Nourizadeh-Lillabadi, Rasoul; Marée, Raphaël ULg et al

in PLoS ONE (2015), in press

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire ... [more ▼]

Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire organism is still incomplete. We used altered gravity and drug treatment experiments to evaluate their effects specifically on bone formation and more generally on whole genome gene expression. By combining morphometric tools with an objective scoring system for the state of development for each element in the head skeleton and specific gene expression analysis, we confirmed and characterized in detail the decrease or increase of bone formation caused by a 5 day treatment (from 5dpf to 10 dpf) of, respectively parathyroid hormone (PTH) or vitamin D3 (VitD3). Microarray transcriptome analysis after 24 hours treatment reveals a general effect on physiology upon VitD3 treatment, while PTH causes more specifically developmental effects. Hypergravity (3g from 5dpf to 9 dpf) exposure results in a significantly larger head and a significant increase in bone formation for a subset of the cranial bones. Gene expression analysis after 24 hrs at 3g revealed differential expression of genes involved in the development and function of the skeletal, muscular, nervous, endocrine and cardiovascular systems. Finally, we propose a novel type of experimental approach, the "Reduced Gravity Paradigm", by keeping the developing larvae at 3g hypergravity for the first 5 days before returning them to 1g for one additional day. 5 days exposure to 3g during these early stages also caused increased bone formation, while gene expression analysis revealed a central network of regulatory genes (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity. [less ▲]

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See detailFinite element modelling of composite structures under crushing load
Chiu, Louis N.S.; Falzon, Brian G.; Boman, Romain ULg et al

in Composite Structures (2015)

This paper details the theory and implementation of a composite damage model, addressing damage within a ply (intralaminar) and delamination (interlaminar), developed for the simulation of the crushing of ... [more ▼]

This paper details the theory and implementation of a composite damage model, addressing damage within a ply (intralaminar) and delamination (interlaminar), developed for the simulation of the crushing of laminated composite structures. It includes a more accurate determination of the characteristic length to achieve mesh objectivity in capturing intralaminar damage consisting of matrix cracking and fibre failure, a load-history dependent material response, an isotropic hardening nonlinear matrix response, as well as a more physically-based interactive matrix damage mechanism. The developed damage model requires a set of material parameters obtained from a combination of standard and non-standard material characterisation tests. The fidelity of the model mitigates the need to manipulate, or “calibrate”, the input data to achieve good agreement with experimental results. This intralaminar damage model was implemented as a VUMAT subroutine, and used in conjunction with an existing interlaminar damage model, in Abaqus/Explicit. This approach was validated through the simulation of the crushing of a cross-ply composite tube with a tulip-shaped trigger, loaded in uniaxial compression. Despite the complexity of the chosen geometry, excellent correlation was achieved with experimental results. [less ▲]

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See detailThe ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating patterning of prethalamus and ventral telencephalon.
Magnani, D; Morlé, L; Hasenpusch-Theil, K et al

in Human Molecular Genetics (2015)

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of ... [more ▼]

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of primary cilia underlie a large number of human syndromes collectively referred to as ciliopathies. Often, ciliopathies are associated with mental retardation (MR) and malformation of the corpus callosum. However, the possibility of defects in other forebrain axon tracts, which could contribute to the cognitive disorders of these patients, has not been explored. Here, we investigate the formation of the corticothalamic/thalamocortical tracts in mice mutant for Rfx3, which regulates the expression of many genes involved in ciliogenesis and cilia function. Using DiI axon tracing and immunohistochemistry experiments, we show that some Rfx3-/- corticothalamic axons abnormally migrate toward the pial surface of the ventral telencephalon (VT). Some thalamocortical axons (TCAs) also fail to leave the diencephalon or abnormally project toward the amygdala. Moreover, the Rfx3-/- VT displays heterotopias containing attractive guidance cues and expressing the guidance molecules Slit1 and Netrin1. Finally, the abnormal projection of TCAs toward the amygdala is also present in mice carrying a mutation in the Inpp5e gene, which is mutated in Joubert Syndrome and which controls cilia signaling and stability. The presence of identical thalamocortical malformations in two independent ciliary mutants indicates a novel role for primary cilia in the formation of the corticothalamic/thalamocortical tracts by establishing the correct cellular environment necessary for its development. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2015), 11

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See detailEffect of improved feeding and housing, Friesian blood level and parity on milk production of Ankole x Friesian cows
Kibwana, Denise Katungu; Makumyaviri, A.M.; Hornick, Jean-Luc ULg

in Pakistan Veterinary Journal (2015), 35(1), 76-80

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk ... [more ▼]

In North Kivu, D.R. Congo, cattle are raised in extensive systems based on local breeds and crossbreds. This farming method affects the performance of dairy animals and mortgages the level of milk consumption in population. An improved farming system, including feed supplementation, Friesian cross-breeding and the sheltering of animals in stalls at night, was studied to evaluate its effect on milk production by Ankole x Friesian crossbreds. The study was performed in Beni, D.R. Congo, on two groups of 15 animals (control group-CoG and improved group-IG), homogeneous according to Friesian blood and parity levels. The improved system, Friesian blood and parity levels increased significantly milk production (P<0.001). Farming system increased milk production by 1.6 l/d (5.2 l/d vs 6.8 l/d respectively in CoG and IG). Milk production ranged from 5.3±0.04 l/d to 6.6±0.02 l/d and from 4.9±0.02 l/d to 7.2±0.02 l/d according, respectively, to Friesian blood level and parity. A significant interaction was observed between farming system and Friesian blood level, and between farming system and parity (P<0.001). The two groups were characterized by a fair adaptation to forage availability associated to climatic factors. The study showed the importance of genetic and environmental factors on the milk production of crossbred dairy cows of the region. [less ▲]

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See detailDynamics of greenhouse gases (CO2, CH4, N2O) along the Zambezi River and major tributaries, and their importance in the riverine carbon budget
Teodoru, C. R.; Nyoni, F. C.; Borges, Alberto ULg et al

in Biogeosciences (2015), 12(8), 2431-2453

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See detailComparative biogeochemistry-ecosystem-human interactions on dynamic continental margins
Levin, Lisa A.; Liu, Kon-Kee; Kay-Christian, Emeis et al

in Journal of Marine Systems (2015), 141

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions ... [more ▼]

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins. [less ▲]

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See detailTrophodynamics of estuarine intertidal harpacticoid copepods based on stable isotope composition and fatty acid profiles
Cnudde, Clio; Moens, Tom; Werbrouck, Eva et al

in Marine Ecology. Progress Series (2015), 524

Trophic interactions at the basis of food webs, for instance between meiofauna, primary producers and bacteria, are key drivers of benthic energy fluxes. Yet both qualitative and quantitative information ... [more ▼]

Trophic interactions at the basis of food webs, for instance between meiofauna, primary producers and bacteria, are key drivers of benthic energy fluxes. Yet both qualitative and quantitative information about meiofaunal resource utilization under in situ conditions is scant. By means of natural stable isotope ratios of carbon and nitrogen and of fatty acid (FA) profiles, we examined the variability of in situ resource utilization of a range of harpacticoid copepod species from 5 stations in an estuarine intertidal area. These stations, located in different habitats, differed in sediment granulometry, resource availability, presence/absence of vegetation and other environmental variables, as well as in copepod species composition. Our goal was to describe inter-specific differences among harpacticoid species, as well as spatio-temporal variability within species. Despite differences in resource availability between habitats, δ13C data clearly point at microphytobenthos (MPB) as the major carbon source to the harpacticoid assemblages at all 5 stations. Small differences in carbon isotopic ratios between co-occurring species indicate some degree of resource differentiation, whereas both the δ15N and FA composition suggest that several harpacticoid species obtain MPB carbon indirectly, perhaps through feeding on bacteria or ciliates. For a limited number of species, such as Paraleptastacus spinicauda, clear dietary contributions of suspended particulate matter and bacteria were found, and MPB appeared to have only a small or no contribution. Even in vegetated salt-marsh stations, Spartina anglica detritus did not appear to contribute to copepod diets. The δ13C of Cletodidae were highly depleted, reflecting a contribution of methane-derived carbon. [less ▲]

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See detailRelation between global end-diastolic volume and left ventricular end-diastolic volume
Pironet, Antoine ULg; MORIMONT, Philippe ULg; Kamoi, S. et al

in Critical Care (2015), 19(Suppl 1), 175

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See detailBlood alcohol concentration in drivers of Liege aera (Belgium) : a 5-year analysis
DEVILLE, Marine ULg; Charlier, Corinne ULg

in Acta Clinica Belgica (2015), 00

Objectives: The objective of the present study was to describe the results of the blood alcohol determinations made on drivers from the Liege area between July 2007 and December 2012. Methods: The results ... [more ▼]

Objectives: The objective of the present study was to describe the results of the blood alcohol determinations made on drivers from the Liege area between July 2007 and December 2012. Methods: The results were interpreted according to the sex, to the age, to the circumstances and temporal variation of the blood test. Statistical analysis was performed using R® software. Results: During this 5-years period, 2725 determinations were done, mainly in the context of road crashes. The mean blood alcohol concentration (BAC) was 1.69 g/L, and 2132 drivers were above the legal threshold. A large majority of offenders (77%) were men, but the mean BAC did not differ significantly between men (1.69 g/L) and women (1.67 g/L). A statistically significant correlation between age and mean BAC can be observed, if we only consider the positive cases. Concerning the temporal variation of the results, lowest mean BACs are observed during the daytime while highest mean BACs are measured during the night. In both cases, no statistically significant difference can be observed if we compare the week and the weekend. Finally, no statistically significant difference in BAC was observed over years. [less ▲]

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See detailFilter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis.
Grange, Laura; Bureau, Jean-Francois; Nikolayeva, Iryna et al

in BMC genetics (2015), 16(1), 11

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the ... [more ▼]

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the heritability of traits and diseases. Epistasis, one potentially important cause of this missing heritability, is difficult to explore at the genome-wide level. Here, we develop and assess a tool based on interactive odds ratios (IOR), Fast Odds Ratio-based sCan for Epistasis (FORCE), as a novel approach for exhaustive genome-wide epistasis search. IOR is the ratio between the multiplicative term of the odds ratio (OR) of having each variant over the OR of having both of them. By definition, an IOR that significantly deviates from 1 suggests the occurrence of an interaction (epistasis). As the IOR is fast to calculate, we used the IOR to rank and select pairs of interacting polymorphisms for P value estimation, which is more time consuming.ResultsFORCE displayed power and accuracy similar to existing parametric and non-parametric methods, and is fast enough to complete a filter-free genome-wide epistasis search in a few days on a standard computer. Analysis of psoriasis data uncovered novel epistatic interactions in the HLA region, corroborating the known major and complex role of the HLA region in psoriasis susceptibility.ConclusionsOur systematic study revealed the ability of FORCE to uncover novel interactions, highlighted the importance of exhaustiveness, as well as its specificity for certain types of interactions that were not detected by existing approaches. We therefore believe that FORCE is a valuable new tool for decoding the genetic basis of complex diseases. [less ▲]

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See detailThe origin and control of mega-gullies in Kinshasa (D.R. Congo)
Makanzu Imwangana, Fils; Vandecasteele, Ine; Trefois, Philippe et al

in Catena (2015), 125

This study aims to investigate the relation between mega-gully (> 5 m width) distribution and urbanization in Kinshasa (D.R. Congo), to establish what governs mega-gully location and plan form and to ... [more ▼]

This study aims to investigate the relation between mega-gully (> 5 m width) distribution and urbanization in Kinshasa (D.R. Congo), to establish what governs mega-gully location and plan form and to illustrate the concepts behind mega-gully treatment. For this purpose, the diachronic distribution of mega-gullies has been mapped in Kinshasa. All mega-gullies have been reported in ArcGis 9.3 on the orthorectified SPOT 2007 image. A newly elaborated DEM enables the mega-gullies to be placed in their natural topographical context. The GIS inventory on the SPOT 2006/2007 anaglyph indicates the mega-gully situation in the high town of Kinshasa 5 years ago: 308 mega-gullies with a cumulated length of 94.7 km, a mean drainage density of 0.4 km km− 2 and an average width and depth of 17 m and 6 m respectively. On the WorldView 1 (WV1) coverage, the number of mega-gullies has more than doubled between 2007 and 2010 from 160 to 334. The study shows that mega-gullies only develop within the urbanized perimeter of the high town of Kinshasa and only 5 to 10 years after incipient urbanization. The study also indicates that neither the location, the plan form or the downslope course of mega-gullies in Kinshasa are controlled by the natural topography. Forty-three point eight percent of the mega-gullies in Kinshasa are ‘axial’, occupying urban structures which function as artificial runoff drainage lines: roads, tarred or not, with or without side-road trenches, gutters in all forms and materials from concrete to sand, also foot paths and further all artificial runoff drainage lines. The study reveals that every mega-gully is directly or indirectly induced by human activities, but that every gully also finally ends to grow after an initial phase of sudden development. Mega-gully treatment follows two principles, often combined. The first is to stop the alimentation of the mega-gully head with water. The second includes a complete stabilization of the channel and walls inside the mega-gully. This study emphasizes that gully prevention can basically be achieved by control of the runoff discharges in the artificial stream network, as well as beside the roads. [less ▲]

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See detail¿Quién mató a Rosario Tijeras? Narco y culpa.
Vanden Berghe, Kristine ULg

in Bulletin of Spanish Studies (2015), 92(2), 2-19

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for ... [more ▼]

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for the murder of the female assassin. Taking into account the serious psychological instability of the narrator and the violations of the maxims of communicative cooperation, it is argued that he is an unreliable narrator. Such a reading of the novel as a detective story told by an unreliable narrator reveals a number of clues as to who murdered Rosario Tijeras. It also paves the way towards a new interpretation of the novel: this article argues that there is a parallelism between Franco Ramos’ novel and La virgen de los Sicarios (1994) by Fernando Vallejo: in both novels the issues of violence and guilt in societies dominated by drug trafficking are treated in a similar way. [less ▲]

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See detailAnalysis of high frequency geostationary ocean colour data using DINEOF
Alvera Azcarate, Aïda ULg; Vanhellemont, Quinten; Ruddick, Kevin et al

in Estuarine Coastal & Shelf Science (2015), 159

DINEOF (Data Interpolating Empirical Orthogonal Functions), a technique to reconstruct missing data, is applied to turbidity data obtained through the Spinning Enhanced Visible and Infrared Imager (SEVIRI ... [more ▼]

DINEOF (Data Interpolating Empirical Orthogonal Functions), a technique to reconstruct missing data, is applied to turbidity data obtained through the Spinning Enhanced Visible and Infrared Imager (SEVIRI) on board Meteosat Second Generation 2. The aim of this work is to assess if the tidal variability of the southern North Sea in 2008 can be accurately reproduced in the reconstructed dataset. Such high frequency data have not previously been analysed with DINEOF and present new challenges, like a strong tidal signal and long night-time gaps. An outlier detection approach that exploits the high temporal resolution (15 min) of the SEVIRI dataset is developed. After removal of outliers, the turbidity dataset is reconstructed with DINEOF. In situ Smartbuoy data are used to assess the accuracy of the reconstruction. Then, a series of tidal cycles are examined at various positions over the southern North Sea. These examples demonstrate the capability of DINEOF to reproduce tidal variability in the reconstructed dataset, and show the high temporal and spatial variability of turbidity in the southern North Sea. An analysis of the main harmonic constituents (annual cycle, daily cycle, M2 and S2 tidal components) is performed, to assess the contribution of each of these modes to the total variability of turbidity. The variability not explained by the harmonic fit, due to the natural processes and satellite processing errors as noise, is also assessed. [less ▲]

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See detailMise en perspective de l'après-midi de rencontre avec les maîtres de stages du Cifen
Simons, Germain ULg

in Didactiques en pratique (2015), 1

Ce texte est le discours du Président du Cifen qui a été prononcé à l'occasion de la première journée officielle de rencontre entre le Centre et les maitres de stages (5 novembre 2014). Ce discours ... [more ▼]

Ce texte est le discours du Président du Cifen qui a été prononcé à l'occasion de la première journée officielle de rencontre entre le Centre et les maitres de stages (5 novembre 2014). Ce discours succinct reprend la question qui a servi de fil rouge à cette journée : "Comment collaborer efficacement pour accompagner au mieux nos stagiaires ?" et en détaille chaque composante. [less ▲]

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See detailDoes reward unpredictability reflect risk?
Anselme, Patrick ULg

in Behavioural Brain Research (2015), 280(1), 119-127

Most decisions made in real-life situations are risky because they are associated with possible negative consequences. Current models of decision-making postulate that the occasional, unpredictable ... [more ▼]

Most decisions made in real-life situations are risky because they are associated with possible negative consequences. Current models of decision-making postulate that the occasional, unpredictable absence of reward that may result from free choice is a negative consequence interpreted as risk by organisms in laboratory situations. I argue that such a view is difficult to justify because, in most experimental paradigms, reward omission does not represent a cost for the decision maker. Risk only exists when unpredictability may cause a potential loss of own limited resources, whether energetic, social, financial, and so on. Thus the experimental methodologies used to test humans and non-humans relative to risk-taking seem to be limited to studying the effects of reward uncertainty in the absence of true decision cost. This may have important implications for the conclusions that can be drawn with respect to the neurobehavioural determinants of risk-taking in real-life situations. [less ▲]

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