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See detailNuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury.
Jouret, François ULg; Leenders, Justine ULg; Defraigne, Jean-Olivier ULg et al

in PLoS ONE (2016), 11(9), 1-14

Abstract BACKGROUND: Ischemia/reperfusion (I/R) is the most common cause of acute kidney injury (AKI). Its pathophysiology remains unclear. Metabolomics is dedicated to identify metabolites involved in ... [more ▼]

Abstract BACKGROUND: Ischemia/reperfusion (I/R) is the most common cause of acute kidney injury (AKI). Its pathophysiology remains unclear. Metabolomics is dedicated to identify metabolites involved in (patho)physiological changes of integrated living systems. Here, we performed 1H-Nuclear Magnetic Resonance metabolomics using urine, serum and kidney samples from a mouse model of renal I/R. METHODS: Renal 30-min ischemia was induced in 12-week-old C57BL/6J male mice by bilaterally clamping vascular pedicles, and was followed by 6, 24 or 48-hour reperfusion (n = 12/group). Sham-operated mice were used as controls. Statistical discriminant analyses, i.e. principal component analysis and orthogonal projections to latent structures (OPLS-DA), were performed on urine, serum and kidney lysates at each time-point. Multivariate receiver operating characteristic (ROC) curves were drawn, and sensitivity and specificity were calculated from ROC confusion matrix (with averaged class probabilities across 100 cross-validations). RESULTS: Urine OPLS-DA analysis showed a net separation between I/R and sham groups, with significant variations in levels of taurine, di- and tri-methylamine, creatine and lactate. Such changes were observed as early as 6 hours post reperfusion. Major metabolome modifications occurred at 24h post reperfusion. At this time-point, correlation coefficients between urine spectra and conventional AKI biomarkers, i.e. serum creatinine and urea levels, reached 0.94 and 0.95, respectively. The area under ROC curve at 6h, 24h and 48h post surgery were 0.73, 0.98 and 0.97, respectively. Similar discriminations were found in kidney samples, with changes in levels of lactate, fatty acids, choline and taurine. By contrast, serum OPLS-DA analysis could not discriminate sham-operated from I/R-exposed animals. CONCLUSIONS: Our study demonstrates that renal I/R in mouse causes early and sustained metabolomic changes in urine and kidney composition. The most implicated pathways at 6h and 24h post reperfusion include gluconeogenesis, taurine and hypotaurine metabolism, whereas protein biosynthesis, glycolysis, and galactose and arginine metabolism are key at 48h post reperfusion. [less ▲]

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See detailDouble-slit experiment in momentum space
Ivanov, Igor ULg; Seipt, Daniel; Surzhykov, Andrey et al

in Europhysics Letters (2016), 115(4), 41001

Young's classic double-slit experiment demonstrates the reality of interference when waves and particles travel simultaneously along two different spatial paths. Here, we propose a double-slit experiment ... [more ▼]

Young's classic double-slit experiment demonstrates the reality of interference when waves and particles travel simultaneously along two different spatial paths. Here, we propose a double-slit experiment in momentum space, realized in the free-space elastic scattering of vortex electrons. We show that this process proceeds along two paths in momentum space, which are well localized and well separated from each other. For such vortex beams, the (plane-wave) amplitudes along the two paths acquire adjustable phase shifts and produce interference fringes in the final angular distribution. We argue that this experiment can be realized with the present-day technology. We show that it gives experimental access to the Coulomb phase, a quantity which plays an important role in all charged particle scattering but which usual scattering experiments are insensitive to. [less ▲]

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See detailImpacts of ikaite export from sea ice to the underlying seawater in a sea ice-seawater mesocosm
Geilfus, N.-X.; Galley, R. J.; Else, B. G. T. et al

in Cryosphere (The) (2016), 10

Ikaite precipitation within sea ice could act as a significant sink for atmospheric CO2. However, the fate of these ikaite crystals is still poorly understood. We quantify temporal inorganic carbon ... [more ▼]

Ikaite precipitation within sea ice could act as a significant sink for atmospheric CO2. However, the fate of these ikaite crystals is still poorly understood. We quantify temporal inorganic carbon dynamics from initial sea ice formation from open water to its melt during a month-long experiment in a sea ice-seawater mesocosm pool. Within sea ice, ikaite precipitation and CO2 exchange with the atmosphere were the main processes affecting inorganic carbon dynamics, while the dissolution of ikaite was the main process affecting inorganic carbon dynamics in the underlying seawater. Based on the total alkalinity (TA) and total dissolved inorganic carbon (TCO2) within sea ice and seawater, we estimated ikaite precipitated up to 167 ± 3 µmol kg-1 within sea ice; up to 57 % of the ikaite precipitated within sea ice was exported to the underlying seawater where it was dissolved. Ikaite export from the ice to the underlying seawater was associated with brine rejection during sea ice growth, increased sea ice vertical connectivity due to the upward percolation of seawater, and meltwater flushing during sea ice melt. The dissolution of the ikaite crystals in the water column kept the seawater pCO2 undersaturated compared to the atmosphere in spite of increased salinity, TA, and TCO2 associated with sea ice growth. Results indicate that ikaite export from sea ice and its dissolution in the underlying seawater can potentially hamper the effect of oceanic acidification on the aragonite saturation state (Ωaragonite) in fall and winter in ice-covered areas, at the time when Ωaragonite is smallest. [less ▲]

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See detailT2-weighted MRI signal predicts hormone and tumor responses to somatostatin analogs in acromegaly.
Potorac, Iulia ULg; PETROSSIANS, Patrick ULg; Daly, Adrian ULg et al

in Endocrine-Related Cancer (2016), 23(11), 871881

GH-secreting pituitary adenomas can be hypo-, iso- or hyperintense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the ... [more ▼]

GH-secreting pituitary adenomas can be hypo-, iso- or hyperintense on T2-weighted MRI sequences. We conducted the current multicenter study in a large population of patients with acromegaly to analyze the relationship between T2-weighted signal intensity on diagnostic MRI and hormonal and tumoral responses to somatostatin analogs (SSA) as primary monotherapy. Acromegaly patients receiving primary SSA for at least 3 months were included in the study. Hormonal, clinical and general MRI assessments were performed and assessed centrally. We included 120 patients with acromegaly. At diagnosis, 84, 17 and 19 tumors were T2-hypo-, iso- and hyperintense, respectively. SSA treatment duration, cumulative and mean monthly doses were similar in the three groups. Patients with T2-hypointense adenoma had median SSA-induced decreases in GH and IGF-1 of 88% and 59% respectively, which were significantly greater than the decreases observed in the T2-iso- and hyperintense groups (p<0.001). Tumor shrinkage on SSA was also significantly greater in the T2-hypointense group (38%) compared with the T2-iso- and hyperintense groups (8% and 3%, respectively; p<0.0001). The response to SSA correlated with the calculated T2-intensity: the lower the T2-weighted intensity, the greater the decrease of random GH (p<0.0001, r=0.22), IGF-1 (p<0.0001, r=0.14) and adenoma volume (p<0.0001, r=0.33). The T2-weighted signal intensity of GH-secreting adenomas at diagnosis correlates with the hormone reduction and tumor shrinkage in response to primary SSA treatment in acromegaly. This study supports its use as a generally available predictive tool at diagnosis that could help to guide subsequent treatment choices in acromegaly. [less ▲]

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See detailThe link between self-perceptions of aging, cancer view and physical and mental health of older people with cancer: A cross-sectional study
Schroyen, Sarah ULg; Marquet, Manon ULg; Jerusalem, Guy ULg et al

in Journal of Geriatric Oncology (2016)

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has ... [more ▼]

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has never been studied in the elderly population. Similarly, even though it is established that a negative self-perception of aging has deleterious consequences on mental and physical health in normal aging, the influence in pathological contexts, such as oncology, has not been studied. The main aim of this study is thus to analyze the effect of these two stigmas on the health of elderly oncology patients. Materials and Methods 101 patients suffering from a cancer (breast, gynecological, lung or hematological) were seen as soon as possible after their diagnosis. Their self-perception of age, cancer view and health (physical and mental) was assessed. Results Multiple regressions showed that patients with a more negative self-perception of aging and/or more negative cancer view reported poorer global health. We also observed that negative self-perception of aging was associated with worse physical and mental health, whereas negative cancer views were only linked to worse mental health. No interaction was observed between these two stigmas, suggesting that their action is independent. Conclusion Older patients with cancer face double stigmatization, due to negative self-perception of aging and cancer, and these stigmas have impacts on global and mental health. Self-perception of aging is also linked to physical health. Longitudinal studies will be necessary to analyze the direction of the association between this double stigmatization and health. [less ▲]

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See detailLes déclarations non vérifiées de témoins au regard du procès équitable
Michiels, Olivier ULg; Falque, Géraldine ULg

in Journal des Tribunaux (2016), (6656), 485-490

Dans l’arrêt Schatschaschwili contre Allemagne, la Cour européenne des droits de l’homme s’est particulièrement attachée à préciser les principes qui s’appliquent aux déclarations d’un témoin absent au ... [more ▼]

Dans l’arrêt Schatschaschwili contre Allemagne, la Cour européenne des droits de l’homme s’est particulièrement attachée à préciser les principes qui s’appliquent aux déclarations d’un témoin absent au procès, susceptibles de fonder la culpabilité d’un accusé. Les éclaircissements que l’arrêt de la Grande Chambre ambitionne d’apporter à ce sujet retiendront notre attention dès lors que l’équité du procès pourrait être compromise par la déposition d’un témoin que la défense n’a pas pu, directement ou indirectement, faire interroger. Après avoir rappelé le contexte factuel et procédural dans lequel s’inscrit la cause, nous tenterons de dégager les lignes de force de l’arrêt commenté. Enfin, nous nous efforcerons de mettre ces enseignements en perspective avec la jurisprudence de la cour de Cassation relative à l’article 6, § 3, d) de la Convention qui reconnaît notamment le droit à tout accusé d’interroger ou faire interroger un témoin à charge, pour terminer par une brève conclusion. [less ▲]

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See detailDelay Compensation for Real Time Disturbance Estimation at Extremely Large Telescopes
Bohm, Michael; Pott, Jorg-Uwe; Kurster, Martin et al

in IEEE Transactions on Control Systems Technology (2016), PP(99), 10

In ground-based astronomy, aberrations due to structural vibrations, such as piston, limit the achievable resolution and cannot be corrected using adaptive optics (AO) for large telescopes. We present a ... [more ▼]

In ground-based astronomy, aberrations due to structural vibrations, such as piston, limit the achievable resolution and cannot be corrected using adaptive optics (AO) for large telescopes. We present a model-free strategy to estimate and compensate piston aberrations due to the vibrations of optical components using accelerometer disturbance feed forward, eventually allowing the use of fainter guide stars both for the fringe detector and in the AO loop. Because the correction performance is very sensitive to signal delays, we present a strategy to add a delay compensation to the developed disturbance estimator, which can, in principle, be applied to many other applications outside of astronomy that lack observer performance due to a measurement delay or need a prediction to compensate for input delays. The ability to estimate vibration disturbances in the critical frequency range of 8-60 Hz is demonstrated with on sky data from the Large Binocular Telescope (LBT) Interferometer, an interferometer at the LBT. The experimental results are promising, indicating the ability to suppress differential piston induced by telescope vibrations by a factor of about 3 (rms), which is significantly better than any currently commissioned system. [less ▲]

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See detailSteady-state and dynamic validation of a small scale waste heat recovery system using the ThermoCycle Modelica library
Desideri, Adriano ULg; Hernandez, Andres; Gusev, Sergei et al

in Energy (2016), 115

The organic Rankine cycle (ORC) power system has been recognized as a promising technology for micro power applications. In this context, physics-based dynamic models can constitute a significant tool for ... [more ▼]

The organic Rankine cycle (ORC) power system has been recognized as a promising technology for micro power applications. In this context, physics-based dynamic models can constitute a significant tool for the further development of the technology, allowing to evaluate and optimize response times during transients, or to implement and test innovative control strategies. In this contribution, the dynamic model of an ORC power unit based on the ThermoCycle Modelica library is validated against steady-state and transient experimental results from an 11 kWel stationary ORC system. The simulation results are in good agreement with the measurements, both in steady-state and in transient conditions. The validated library is readily usable to investigate demanding dynamics-based problems for low capacity power systems. [less ▲]

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See detailActivating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas
Vallois, David; Dobay, Maria Pamela D.; Morin, Ryan D. et al

in Blood (2016), 128

Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with poorly understood ... [more ▼]

Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with poorly understood pathogenesis and unfavorable treatment results. We investigated a series of 85 patients with AITL (n 5 72) or other TFH-derived PTCL (n 5 13) by targeted deep sequencing of a gene panel enriched in T-cell receptor (TCR) signaling elements. RHOA mutations were identified in 51 of 85 cases (60%) consisting of the highly recurrent dominant negative G17V variant in most cases and a novel K18N in 3 cases, the latter showing activating properties in in vitro assays. Moreover, half of the patients carried virtually mutually exclusive mutations in other TCR-related genes, most frequently in PLCG1 (14.1%), CD28 (9.4%, exclusively in AITL), PI3K elements (7%), CTNNB1 (6%), and GTF2I (6%). Using in vitro assays in transfected cells, we demonstrated that 9 of 10 PLCG1 and 3 of 3 CARD11 variants induced MALT1 protease activity and increased transcription from NFAT or NF-kB response element reporters, respectively. Collectively, the vast majority of variants in TCR-related genes could be classified as gain-of-function. Accordingly, the samples with mutations in TCR-related genes other than RHOA had transcriptomic profiles enriched in signatures reflecting higher T-cell activation. Although no correlationwithpresenting clinical featuresnor significantimpacton survivalwasobserved, thepresenceofTCR-relatedmutations correlated with early disease progression. Thus, targeting of TCR-related eventsmay hold promise for the treatment of TFH-derived lymphomas. [less ▲]

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See detailAcoustic indices provide information on the status of coral reefs: an example from Moorea Island in the South Pacific
Bertucci, Frédéric; Parmentier, Eric ULg; Lecellier, Gaël et al

in Scientific Reports (2016), 6(33326), 1-9

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See detailPredicting the dynamic impact behaviour of spray droplets on flat plant surfaces
Delele, Mulugeta Admasu; Nuyttens, David; Douga, Ashenafitilahun T. et al

in Soft Matter (2016), 12 (34)(7), 195-211

The dynamic impact behaviour of water droplets on plant surfaces was investigated based on a multiphase computational fluid dynamics (CFD) model. The study was conducted using the Volume Of Fluid (VOF ... [more ▼]

The dynamic impact behaviour of water droplets on plant surfaces was investigated based on a multiphase computational fluid dynamics (CFD) model. The study was conducted using the Volume Of Fluid (VOF) approach. The static contact angle of water droplets on leaf surfaces of different plants (apple, pear, leek and cabbage) was measured and found to vary between 54.9 and 138.2°. Impact experiments were conducted by monitoring the flow and impact characteristics of water droplets on leaves in still air with a high speed camera. Droplets were generated by an agricultural flat fan spray nozzle moving across the leaf at constant speed. The nozzle produced droplets with diameters ranging from 20.6 up to 550.8 μm, and droplet velocity values near the impact between 0.03 and 13.2 m s(-1). The CFD model was capable of predicting the observed dynamic impact behaviour of droplets on the plant surfaces. The fate of the droplets after the impact process for adhesion, bouncing or splashing was accurately predicted for Weber numbers (We) in the range of 0.007 to 1096 and droplet Reynolds numbers (Re) between 5 to 8000. The process was highly dependent on the surface and droplet flow characteristics during the impact. Combinations of We, Re and Ohnesorge (Oh) numbers defined the droplet maximum spread factor, the number of secondary droplets generated as a result of the splashing process and the transition between the different impact outcomes. These criteria can then be used in field scale spray deposition and drift models to better understand agricultural spray operations. [less ▲]

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See detailDirect measurement of evapotranspiration from a forest using a superconducting gravimeter
Van Camp, Michel; de Viron, Olivier; Pajot-Métivier, Gwendoline et al

in Geophysical Research Letters (2016), 43

Evapotranspiration (ET) controls the flux between the land surface and the atmosphere. Assessing the ET ecosystems remains a key challenge in hydrology. We have found that the ET water mass loss can be ... [more ▼]

Evapotranspiration (ET) controls the flux between the land surface and the atmosphere. Assessing the ET ecosystems remains a key challenge in hydrology. We have found that the ET water mass loss can be directly inferred from continuous gravity measurements: as water evaporates and transpires from terrestrial ecosystems, the mass distribution of water decreases, changing the gravity field. Using continuous superconducting gravity measurements, we were able to identify daily gravity changes at the level of, or smaller than, 10-9 nms-2 (or 10-10 g) per day. This corresponds to 1.7mmof water over an area of 50 ha. The strength of this method is its ability to enable a direct, traceable and continuous monitoring of actual ET for years at the mesoscale with a high accuracy. [less ▲]

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See detailEffects of equine chorionic gonadotropin (eCG) on the sexual behaviour and ovulatory characteristics of female african N'Dama cattle.
Okouyi, M.W. Marcel; Hanzen, Christian ULg

in Revue de Médecine Vétérinaire (2016), 167(7-8), 211-215

This paper evaluated the effects of eCG on the characteristics of oestrus and ovulation after heifers and cows had been synchronised following vaginal administration of progesterone for seven days ... [more ▼]

This paper evaluated the effects of eCG on the characteristics of oestrus and ovulation after heifers and cows had been synchronised following vaginal administration of progesterone for seven days (Controlled Internal Drug Released) and a PGF2α injection two days after the end of treatment. The animals were randomly split into a non-treated control group (n=26) and four groups with increasing doses of eCG: 300 IU (n=25), 400 IU (n=24), 500 IU (n=23) and 600 IU (n=23), which were injected on the day of CIDR withdrawal. The animals were then followed (24 hours a day) for six days. Oestrus was confirmed on the basis of identifying 'standing oestrus', i.e., when the cow stood to be mounted. Seven to ten days after the CIDR® was withdrawn, the animals were slaughtered, and their ovaries were examined to identify and count the number of follicular and/or luteal structures. The onset of heat was 48.6 ± 5.3 hours after eCG injection, and the average length of oestrus was 9.9 ± 2 hours. The eCG dosage had no significant effect on these two parameters. In contrast, the observed rate of oestrus was significantly (p<0.05) higher in animals that had been treated (70.8 to 84.0%) in comparison with animals that had not been treated (50%). Similarly, the ovulation rate was significantly (p<0.05) higher in treated animals (88.0 to 100%) than in untreated animals (73.1%). The percentage of animals that presented multiple ovulations increased significantly (p <0.001) with the dosage of eCG administered (4.5% to 36.4%). [less ▲]

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See detailRaised interferon beta, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma.
da Silva, J.; Hilzendeger, Clarissa ULg; Moermans, Catherine et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2016)

BACKGROUND: Interferons play an important role in innate immunity. Previous studies report deficiency in virus-induction of interferon (IFN)-alpha, -beta and -lambda in bronchial epithelial and bronchial ... [more ▼]

BACKGROUND: Interferons play an important role in innate immunity. Previous studies report deficiency in virus-induction of interferon (IFN)-alpha, -beta and -lambda in bronchial epithelial and bronchial lavage cells in atopic asthmatics. It is now recognized that asthma is a heterogeneous disease comprising different inflammatory phenotypes, some of which may involve innate immune activation in the absence of overt infection. OBJECTIVE: The aim of the study was investigate if the severity of asthma or a specific cellular sputum pattern may be linked to evidence of innate immune activation. METHODS: Here we investigate the expression of IFN-beta, IFN-lambda1 (IL-29), IFN-lambda2/3 (IL-28A/B) and the interferon-stimulated genes (ISGs) myxovirus resistance 1 (Mx1), oligoadenylate synthetase (OAS) and viperin in unstimulated sputum cells in 57 asthmatics (including 16 mild, 19 moderate and 22 severe asthma patients) and compared them with 19 healthy subjects. RESULTS: We observed increased expression of IFN-beta, IFN-lambda1/IL-29, OAS and viperin in asthmatic compared to healthy subjects while IL-28 was not expressed in any group. The overexpression was restricted to neutrophilic asthmatics (sputum neutrophils >/= 76%) while eosinophilic asthmatics (sputum eosinophils >/= 3%) did not differ from healthy subjects or even showed a lower expression of Mx1. No difference in interferon or ISG expression was seen according to clinical asthma severity. CONCLUSION AND CLINICAL RELEVANCE: Neutrophilic, but not eosinophilic, asthmatics display overexpression of IFN-beta, IFN-lambda1/IL-29 and ISGs in their sputum cells that may reflect ongoing innate immune activation. This article is protected by copyright. All rights reserved. [less ▲]

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See detailComparative study of nutritional quality of potato-wheat steamed and baked breads made with four cultivated potato flour
Liu, Xingli; Mu, Tai-Hua; Sun, Hongnan et al

in International Journal of Food Sciences & Nutrition (2016)

Bread is traditional staple food in western and oriental countries varying in both the ingredients used, preparation methods, and heating methods applied, which are mainly used as an energy source because ... [more ▼]

Bread is traditional staple food in western and oriental countries varying in both the ingredients used, preparation methods, and heating methods applied, which are mainly used as an energy source because of high carbohydrate. Baked bread is popular in western countries. While steamed bread is a type of fermented and steamed wheat-based food of Chinese origin, and represents ∼40% of the wheat consumption in China. [less ▲]

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See detailAxIOM: Amphipod crustaceans from insular Posidonia oceanica seagrass meadows
Michel, Loïc ULg; Sturaro, Nicolas ULg; Heughebaert, André et al

in Biodiversity Data Journal (2016), 4

Background The Neptune grass, Posidonia oceanica (L.) Delile, 1813, is the most widespread seagrass of the Mediterranean Sea. This foundation species forms large meadows that, through habitat and trophic ... [more ▼]

Background The Neptune grass, Posidonia oceanica (L.) Delile, 1813, is the most widespread seagrass of the Mediterranean Sea. This foundation species forms large meadows that, through habitat and trophic services, act as biodiversity hotspots. In Neptune grass meadows, amphipod crustaceans are one of the dominant groups of vagile invertebrates, forming an abundant and diverse taxocenosis. They are key ecological components of the complex, pivotal, yet critically endangered Neptune grass ecosystems. Nevertheless, comprehensive qualitative and quantitative data about amphipod fauna found in Mediterranean Neptune grass meadows remain scarce, especially in insular locations. New information Here, we provide in-depth metadata about AxIOM, a sample-based dataset published on the GBIF portal. AxIOM is based on an extensive and spatially hierarchized sampling design with multiple years, seasons, day periods, and methods. Samples were taken along the coasts of Calvi Bay (Corsica, France) and of the Tavolara-Punta Coda Cavallo Marine Protected Area (Sardinia, Italy). In total, AxIOM contains 187 samples documenting occurrence (1775 records) and abundance (10720 specimens) of amphipod crustaceans belonging to 72 species spanning 29 families. The dataset is available at http://ipt.biodiversity.be/resource?r=axiom. [less ▲]

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See detailApplication of GRACE to the assessment of model-based estimates of monthly Greenland Ice Sheet mass balance (2003–2012)
Schlegel, N.; Wiese, D.; Larour, E. et al

in Cryosphere (The) (2016), 10

Quantifying the Greenland Ice Sheet's future contribution to sea level rise is a challenging task that requires accurate estimates of ice sheet sensitivity to climate change. Forward ice sheet models are ... [more ▼]

Quantifying the Greenland Ice Sheet's future contribution to sea level rise is a challenging task that requires accurate estimates of ice sheet sensitivity to climate change. Forward ice sheet models are promising tools for estimating future ice sheet behavior, yet confidence is low because evaluation of historical simulations is challenging due to the scarcity of continental-wide data for model evaluation. Recent advancements in processing of Gravity Recovery and Climate Experiment (GRACE) data using Bayesian-constrained mass concentration ("mascon") functions have led to improvements in spatial resolution and noise reduction of monthly global gravity fields. Specifically, the Jet Propulsion Laboratory's JPL RL05M GRACE mascon solution (GRACE_JPL) offers an opportunity for the assessment of model-based estimates of ice sheet mass balance (MB) at ∼ 300 km spatial scales. Here, we quantify the differences between Greenland monthly observed MB (GRACE_JPL) and that estimated by state-of-the-art, high-resolution models, with respect to GRACE_JPL and model uncertainties. To simulate the years 2003–2012, we force the Ice Sheet System Model (ISSM) with anomalies from three different surface mass balance (SMB) products derived from regional climate models. Resulting MB is compared against GRACE_JPL within individual mascons. Overall, we find agreement in the northeast and southwest where MB is assumed to be primarily controlled by SMB. In the interior, we find a discrepancy in trend, which we presume to be related to millennial-scale dynamic thickening not considered by our model. In the northwest, seasonal amplitudes agree, but modeled mass trends are muted relative to GRACE_JPL. Here, discrepancies are likely controlled by temporal variability in ice discharge and other related processes not represented by our model simulations, i.e., hydrological processes and ice–ocean interaction. In the southeast, GRACE_JPL exhibits larger seasonal amplitude than predicted by the models while simultaneously having more pronounced trends; thus, discrepancies are likely controlled by a combination of missing processes and errors in both the SMB products and ISSM. At the margins, we find evidence of consistent intra-annual variations in regional MB that deviate distinctively from the SMB annual cycle. Ultimately, these monthly-scale variations, likely associated with hydrology or ice–ocean interaction, contribute to steeper negative mass trends observed by GRACE_JPL. Thus, models should consider such processes at relatively high (monthly-to-seasonal) temporal resolutions to achieve accurate estimates of Greenland MB. [less ▲]

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See detailEnabling efficient PET imaging of Synaptic Vesicle glycoprotein 2A (SV2A) with a robust and one-step radiosynthesis of a highly potent 18F-labelled ligand ([18F]UCB-H)
Warnier, Corentin ULg; Lemaire, Christian ULg; Becker, Guillaume ULg et al

in Journal of Medicinal Chemistry (2016), 59

We herein describe the straightforward synthesis of a stable pyridyl(4- methoxyphenyl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F ... [more ▼]

We herein describe the straightforward synthesis of a stable pyridyl(4- methoxyphenyl)iodonium salt and its [18F]radiolabelling within a one-step, fully automated and cGMP compliant radiosynthesis of [18F]UCB-H ([18F]7), a PET tracer for the imaging of Synaptic Vesicle glycoprotein 2A (SV2A). Over the course of one year, 50 automated productions provided 34±2% of injectable [18F]7 from up to 285 GBq (7.7 Ci) of [18F]fluoride in 50 minutes (uncorrected radiochemical yield. Specific Activity = 815±185 GBq/μmol). The successful implementation of our synthetic strategy within routine, high-activity and cGMP productions attests to its practicality and reliability for the production of large doses of [18F]7. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts for the cGMP 18F-PET tracer manufacturing industry, and their ability to fulfill practical and regulatory requirements in that field. [less ▲]

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See detailNon-invasive approaches in the diagnosis of acute rejection in kidney transplant recipients, part II: omics analyses of urine and blood samples
Erpicum, Pauline ULg; HANSSEN, Oriane ULg; WEEKERS, Laurent ULg et al

in Clinical Kidney Journal (2016)

Kidney transplantation (KTx) represents the best available treatment for patients with end-stage renal disease. Still, the full benefits of KTx are undermined by acute rejection (AR). The diagnosis of AR ... [more ▼]

Kidney transplantation (KTx) represents the best available treatment for patients with end-stage renal disease. Still, the full benefits of KTx are undermined by acute rejection (AR). The diagnosis of AR ultimately relies on transplant needle biopsy. However, such an invasive procedure is associated with a significant risk of complications and is limited by sampling error and interobserver variability. In the present review, we summarize the current literature about non-invasive approaches for the diagnosis of AR in kidney transplant recipients (KTRs), including in vivo imaging, gene-expression profiling and omics analyses of blood and urine samples. Most imaging techniques, such as contrast-enhanced ultrasound and magnetic resonance, exploit the fact that blood flow is significantly lowered in case of AR-induced inflammation. In addition, AR-associated recruitment of activated leucocytes may be detectable by 18F-fluorodeoxyglucose positron emission tomography. In parallel, urine biomarkers, including CXCL9/CXCL10 or a three-gene signature of CD3ε, CXCL10 and 18S RNA levels, have been identified. None of these approaches has yet been adopted in the clinical follow-up of KTRs, but standardization of analysis procedures may help assess reproducibility and comparative diagnostic yield in large, prospective, multicentre trials. [less ▲]

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See detailBiomarkers of inflammation and innate immunity in atrophic nonunion fracture
DE SENY, Dominique ULg; COBRAIVILLE, Gaël ULg; Leprince, Pierre ULg et al

in Journal of Translational Medicine (2016)

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See detailThe Envelope Cytoplasmic Tail of HIV-1 Subtype C Contributes to Poor Replication Capacity through Low Viral Infectivity and Cell-to-Cell Transmission.
Santos da Silva, Eveline; Mulinge, Martin; Lemaire, Morgane et al

in PLoS ONE (2016)

The cytoplasmic tail (gp41CT) of the HIV-1 envelope (Env) mediates Env incorporation into virions and regulates Env intracellular trafficking. Little is known about the functional impact of variability in ... [more ▼]

The cytoplasmic tail (gp41CT) of the HIV-1 envelope (Env) mediates Env incorporation into virions and regulates Env intracellular trafficking. Little is known about the functional impact of variability in this domain. To address this issue, we compared the replication of recombinant virus pairs carrying the full Env (Env viruses) or the Env ectodomain fused to the gp41CT of NL4.3 (EnvEC viruses) (12 subtype C and 10 subtype B pairs) in primary CD4+ T-cells and monocyte-derived-macrophages (MDMs). In CD4+ T-cells, replication was as follows: B-EnvEC = B-Env>C-EnvEC>C-Env, indicating that the gp41CT of subtype C contributes to the low replicative capacity of this subtype. In MDMs, in contrast, replication capacity was comparable for all viruses regardless of subtype and of gp41CT. In CD4+ T-cells, viral entry, viral release and viral gene expression were similar. However, infectivity of free virions and cell-to-cell transmission of C-Env viruses released by CD4+ T-cells was lower, suggestive of lower Env incorporation into virions. Subtype C matrix only minimally rescued viral replication and failed to restore infectivity of free viruses and cell-to-cell transmission. Taken together, these results show that polymorphisms in the gp41CT contribute to viral replication capacity and suggest that the number of Env spikes per virion may vary across subtypes. These findings should be taken into consideration in the design of vaccines. [less ▲]

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See detailSeasonal variability of surface and column carbon monoxide over megacity Paris, high-altitude Jungfraujoch and Southern Hemispheric Wollongong stations
Té, Y; Jeseck, P; Franco, Bruno ULg et al

in Atmospheric Chemistry and Physics (2016), 16

This paper studies the seasonal variation of surface and column CO at three different sites (Paris, Jungfraujoch and Wollongong), with an emphasis on establishing a link between the CO vertical ... [more ▼]

This paper studies the seasonal variation of surface and column CO at three different sites (Paris, Jungfraujoch and Wollongong), with an emphasis on establishing a link between the CO vertical distribution and the nature of CO emission sources. We find the first evidence of a time lag between surface and free tropospheric CO seasonal variations in the Northern Hemisphere. The CO seasonal variability obtained from the total columns and free tropospheric partial columns shows a maximum around March–April and a minimum around September–October in the Northern Hemisphere (Paris and Jungfraujoch). In the Southern Hemisphere (Wollongong) this seasonal variability is shifted by about 6 months. Satellite observations by the IASI–MetOp (Infrared Atmospheric Sounding Interferometer) and MOPITT (Measurements Of Pollution In The Troposphere) instruments confirm this seasonality. Ground-based FTIR (Fourier transform infrared) measurements provide useful complementary information due to good sensitivity in the boundary layer. In situ surface measurements of CO volume mixing ratios at the Paris and Jungfraujoch sites reveal a time lag of the near-surface seasonal variability of about 2 months with respect to the total column variability at the same sites. The chemical transport model GEOS-Chem (Goddard Earth Observing System chemical transport model) is employed to interpret our observations. GEOS-Chem sensitivity runs identify the emission sources influencing the seasonal variation of CO. At both Paris and Jungfraujoch, the surface seasonality is mainly driven by anthropogenic emissions, while the total column seasonality is also controlled by air masses transported from distant sources. At Wollongong, where the CO seasonality is mainly affected by biomass burning, no time shift is observed between surface measurements and total column data. [less ▲]

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See detailConsumption patterns, bacteriological quality and risk factors for Salmonella contamination in meat-based meals consumed outside the home in Kigali, Rwanda
Niyonzima, Eugène; Ongol, Martin Patrick; Brostaux, Yves ULg et al

in Food Control (2016)

Meat-based meals are consumed as a source of animal proteins and constitute one of the leading vehicles for food borne infections in humans. The main objective of this study was to determine the ... [more ▼]

Meat-based meals are consumed as a source of animal proteins and constitute one of the leading vehicles for food borne infections in humans. The main objective of this study was to determine the consumption pattern and the bacteriological quality of meat-based meals consumed outside households in Kigali. A survey on meat consumption patterns was carried out in 400 households by using a questionnaire, whereas different meat-based meals were sampled from 150 snack bars and restaurants. Enumeration of hygiene indicator bacteria (total mesophilic bacteria and Escherichia coli) and the qualitative detection of Salmonella were carried out by using conventional culture methods. The results indicated that goat was the type of meat that was consumed the most outside the home in Kigali and the meat intake varied significantly (p ≤0.05) with the social category of the household. The average levels of total aerobic bacteria and E. coli in meat-based meals were found to be 4.7 and 1.4 log cfu/g, respectively, whereas Salmonella was detected in 11.7% of all meat-based meals. Eight factors mostly linked to the cooking treatments and hygienic handling practices for cooked meals were found to be significantly (p ≤ 0.05) associated with the risk of Salmonella occurrence in meat-based meals consumed outside the home in Kigali. The findings from this study strongly suggest the need for proper cooking and/or improvements in hygiene in the establishments selling ready-to-eat meat-based meals in Kigali, particularly those located in rural localities. [less ▲]

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See detailNON-DERMATOPHYTE DERMATOSES MIMICKING DERMATOPHYTOSES IN HUMANS
Libon, Florence ULg; TASSOUDJI, Nazli ULg; DEZFOULIAN, Bita ULg et al

in Mycopathologia (2016)

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the ... [more ▼]

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the intertriginous regions (feet, inguinal, axillar, submammary), dermatophytic colonisations and infections manifest as whitish, slightly hyperkeratotic, pruritic and sometimes fissurated lesions. On the scalp, dermatophytic infections commonly lead to single or multiple more or less inflammatory and alopecic lesions. On the plantar and palmar aspects of the feet and hand, dermatophytosis presents as an eczema-like chronic dermatosis. Abscess-like lesions may occur due to zoophilic dermatomycosis. Dermatophytic infections of the nails reveal ill-defined whitish-yellowish colorations of the distal end or the lateral aspects of the nails, sometimes combined with partial nail embrittlement or even complete destruction. Despite the ubiquity of dermatophytic skin infections and their usually highly typical clinical features, a differential diagnosis has to be considered, in particular when treatment is not efficient or when treatment resistance occurs. This review presents the differential diagnosis in terms of frequency as well as the diagnostic methods permitting the distinction of annular, intertriginous, alopecic, palmoplantar, abscess-like and onychodystrophic lesions. [less ▲]

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See detailChaotic Bohmian trajectories for stationary states
Cesa, Alexandre ULg; Martin, John ULg; Struyve, Ward

in Journal of Physics A: Mathematical and Theoretical (2016), 49

In Bohmian mechanics, the nodes of the wave function play an important role in the generation of chaos. However, so far, most of the attention has been on moving nodes; little is known about the ... [more ▼]

In Bohmian mechanics, the nodes of the wave function play an important role in the generation of chaos. However, so far, most of the attention has been on moving nodes; little is known about the possibility of chaos in the case of stationary nodes. We address this question by considering stationary states, which provide the simplest examples of wave functions with stationary nodes. We provide examples of stationary wave functions for which there is chaos, as demonstrated by numerical computations, for one particle moving in 3 spatial dimensions and for two and three entangled particles in two dimensions. Our conclusion is that the motion of the nodes is not necessary for the generation of chaos. What is important is the overall complexity of the wave function. That is, if the wave function, or rather its phase, has complex spatial variations, it will lead to complex Bohmian trajectories and hence to chaos. Another aspect of our work concerns the average Lyapunov exponent, which quantifies the overall amount of chaos. Since it is very hard to evaluate the average Lyapunov exponent analytically, which is often computed numerically, it is useful to have simple quantities that agree well with the average Lyapunov exponent. We investigate possible correlations with quantities such as the participation ratio and different measures of entanglement, for different systems and different families of stationary wave functions. We find that these quantities often tend to correlate to the amount of chaos. However, the correlation is not perfect, because, in particular, these measures do not depend on the form of the basis states used to expand the wave function, while the amount of chaos does. [less ▲]

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See detailMacro- and near-mesoporous monoliths by medium internal phase emulsion polymerization: a systematic study
Mathieu, Kevin ULg; Jérôme, Christine ULg; Debuigne, Antoine ULg

in Polymer (2016), 99

The synthesis of a series of poly(ethylene oxide)-b-polystyrene copolymers with different block lengths was performed by radical addition fragmentation chain transfer. These amphiphilic copolymers were ... [more ▼]

The synthesis of a series of poly(ethylene oxide)-b-polystyrene copolymers with different block lengths was performed by radical addition fragmentation chain transfer. These amphiphilic copolymers were tested as stabilizers for water-in-oil medium internal phase emulsion (MIPE) templating polymerization and the formation of polyMIPEs with controlled morphology. Aside from the structure of the emulsion stabilizer, several parameters susceptible to influence the size of the cavities and the interconnectivity of the porous monoliths were probed including the choice of the comonomers, treatment of the emulsion by ultrasound, the use of controlled radical polymerization method for the network formation as well as interfacial initiation. Interconnected cellular monoliths were produced. The polymerization of the ultrasonicated water-in-ethylhexylacrylate/divinylbenzene MIPE notably led to near-mesoporous open-cell material. Mechanical properties and specific surface areas of the polyMIPEs were also investigated and discussed. [less ▲]

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See detailThe Gaia-ESO Survey: revisiting the Li-rich giant problem
Casey, A. R.; Ruchti, G.; Masseron, T. et al

in Monthly Notices of the Royal Astronomical Society (2016), 461

The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey ... [more ▼]

The discovery of lithium-rich giants contradicts expectations from canonical stellar evolution. Here we report on the serendipitous discovery of 20 Li-rich giants observed during the Gaia-ESO Survey, which includes the first nine Li-rich giant stars known towards the CoRoT fields. Most of our Li-rich giants have near-solar metallicities and stellar parameters consistent with being before the luminosity bump. This is difficult to reconcile with deep mixing models proposed to explain lithium enrichment, because these models can only operate at later evolutionary stages: at or past the luminosity bump. In an effort to shed light on the Li-rich phenomenon, we highlight recent evidence of the tidal destruction of close-in hot Jupiters at the sub-giant phase. We note that when coupled with models of planet accretion, the observed destruction of hot Jupiters actually predicts the existence of Li-rich giant stars, and suggests that Li-rich stars should be found early on the giant branch and occur more frequently with increasing metallicity. A comprehensive review of all known Li-rich giant stars reveals that this scenario is consistent with the data. However, more evolved or metal-poor stars are less likely to host close-in giant planets, implying that their Li-rich origin requires an alternative explanation, likely related to mixing scenarios rather than external phenomena. [less ▲]

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See detailLes supports des images : de la photographie à l’image numérique
Dondero, Maria Giulia ULg; Reyes, Everardo

in Revue Française des Sciences de l'Information et de la Communication (2016), 9

In this article we deal with questions related to images (painting, photography, digital image) from a semiotic standpoint, more precisely the form and substance of their expression plane. Classical ... [more ▼]

In this article we deal with questions related to images (painting, photography, digital image) from a semiotic standpoint, more precisely the form and substance of their expression plane. Classical greimasian semiotics –mainly through the works of Jean-Marie Floch (1985, 1986) and Félix Thürlemann (1982) – has concentrated on the relation between form of expression and form of content (thus in a semi-symbolic fashion). Then, in the 1990s, Jacques Fontanille started exploring the substance of expression. Later, within the framework of hierarchical levels of analysis, Fontanille (2005, 2008), introduced concepts such as material and formal support in order to distinguish between image as object and image as text. We take into account these works to study the close relationship between the substance of expression of images and the practices of production-reception. [less ▲]

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See detailMagnetically confined wind shocks in X-rays - A review
ud-Doula, Asif; Nazé, Yaël ULg

in Advances in Space Research (2016), 58

A subset (∼ 10%) of massive stars present strong, globally ordered (mostly dipolar) magnetic fields. The trapping and channeling of their stellar winds in closed magnetic loops leads to magnetically ... [more ▼]

A subset (∼ 10%) of massive stars present strong, globally ordered (mostly dipolar) magnetic fields. The trapping and channeling of their stellar winds in closed magnetic loops leads to magnetically confined wind shocks (MCWS), with pre-shock flow speeds that are some fraction of the wind terminal speed. These shocks generate hot plasma, a source of X-rays. In the last decade, several developments took place, notably the determination of the hot plasma properties for a large sample of objects using XMM and Chandra, as well as fully self-consistent MHD modeling and the identification of shock retreat effects in weak winds. Despite a few exceptions, the combination of magnetic confinement, shock retreat and rotation effects seems to be able to account for X-ray emission in massive OB stars. Here we review these new observational and theoretical aspects of this X-ray emission and envisage some perspectives for the next generation of X-ray observatories. [less ▲]

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See detailX-ray emission from interacting wind massive binaries: A review of 15 years of progress
Rauw, Grégor ULg; Nazé, Yaël ULg

in Advances in Space Research (2016), 58

Previous generations of X-ray observatories revealed a group of massive binaries that were relatively bright X-ray emitters. This was attributed to emission of shock-heated plasma in the wind-wind ... [more ▼]

Previous generations of X-ray observatories revealed a group of massive binaries that were relatively bright X-ray emitters. This was attributed to emission of shock-heated plasma in the wind-wind interaction zone located between the stars. With the advent of the current generation of X-ray observatories, the phenomenon could be studied in much more detail. In this review, we highlight the progress that has been achieved in our understanding of the phenomenon over the last 15 years, both on theoretical and observational grounds. All these studies have paved the way for future investigations using the next generation of X-ray satellites that will provide crucial information on the X-ray emission formed in the innermost part of the wind-wind interaction. [less ▲]

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See detailThe influence of England on the first English gardens in the Southern Low Countries and the Principality of Liege
De Harlez De Deulin, Nathalie ULg

in Garden History (2016), 44(Automn), 87-100

The English Garden appearead in the Low Countries quite late in the 18th century since the geometric model – mainly influenced by the French style diffused by the treatise of Dezallier d’Argenville – is ... [more ▼]

The English Garden appearead in the Low Countries quite late in the 18th century since the geometric model – mainly influenced by the French style diffused by the treatise of Dezallier d’Argenville – is still in fashion in the years 1760. Amongst the famous realizations of the time figure the Garden of Leeuwergem Castle (1762), the upper Garden of Freÿr Castle (c. 1775) or the Royal Park of Brussels (1786). The two following decades (1760-1780) correspond to the major development of the new irregular style in the Low Countries merely influenced by Picturesque Garden but also by Naturalistic style Garden discovered by members of the aristocracy travelling in Great Britain as well as some gardeners sent to England to be trained and to learn how to grow new exotic plants. This paper deals with the major designers and the most famous sleeping partners engaged in the program of creation of the first English gardens in the country, notably Prince Charles-Joseph de Ligne (Beloeil and Baudour), Duke Emmanuel de Croÿ (Hermitage), Count of Seneffe Joseph Depestre (Seneffe), Duke Emmanuel d’Hane Steenhuyse (Leeuwergem) and, first of all, Duke Albert de Saxe-Teschen and the Archduchess Marie Christine who asked Lancelot Brown a plan for the site near Brussels called the Fine Mountain (Schoonenberg). Brown has sent his project from Britain in July 1782. We have also taken interest in the many unknown owners who gathered important plants collection that are only described in travel diaries or mentioned in archives (inventories and other lists of purchase or supply) that have no longer survived. This article present some facets of the global research accomplished in the thesis (2015) focusing on the direct influence of the English design on the first irregular gardens in the Southern Low Countries. [less ▲]

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See detailL’étau et le réseau. Recompositions des contextes de travail des équipes de direction pénitentiaire
Dubois, Christophe ULg

in Justice et Sécurité = Justitie en Veiligheid (2016), 7

Résumé : En parcourant les nombreuses études qui décrivent et analysent, depuis plus de vingt ans, le fonctionnement des organisations et des politiques pénitentiaires, trois questions semblent avoir ... [more ▼]

Résumé : En parcourant les nombreuses études qui décrivent et analysent, depuis plus de vingt ans, le fonctionnement des organisations et des politiques pénitentiaires, trois questions semblent avoir jusqu’ici suscité un moindre intérêt scientifique : qui dirige ces organisations ? En quoi consiste le travail des équipes de direction ? Quelle position les membres de ces équipes occupent-ils dans le système organisationnel et politique pénitentiaire belge ? Cet article apporte quelques éléments de réponse à ces questions tout en éclairant les recompositions des contextes de travail des équipes de direction pénitentiaire. Cet éclairage souligne la nécessité de définir politiquement et avec les principaux intéressés un processus de professionnalisation de la fonction qu’ils exercent. [less ▲]

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See detailDésenchanter le cinéma ? Autour de "Blanche-Neige Lucie" de Pierre Huyghe
Tomasovic, Dick ULg

in Mondes du cinéma (2016), 09

Etude des enjeux esthétiques et idéologiques du film "Blanche-Neige Lucie" de Pierre Huyghes.

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See detailSemantic Integration by Pattern Priming: Experiment and Cortical Network Model
Lavigne, Frédéric; Longrée, Dominique ULg; Mellet, Sylvie et al

in Cognitive Neurodynamics (2016), DOI 10.1007/s11571-016-9410-4

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See detailOxytocin in survivors of childhood-onset craniopharyngioma
Daubenbüchel, Anna; Hoffmann, Anika; Eveslage, Maria et al

in Endocrine (2016)

Quality of survival of childhood-onset cranio- pharyngioma patients is frequently impaired by hypotha- lamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits ... [more ▼]

Quality of survival of childhood-onset cranio- pharyngioma patients is frequently impaired by hypotha- lamic involvement or surgical lesions sequelae such as obesity and neuropsychological deficits. Oxytocin, a pep- tide hormone produced in the hypothalamus and secreted by posterior pituitary gland, plays a major role in regula- tion of behavior and body composition. In a cross- sectional study, oxytocin saliva concentrations were ana- lyzed in 34 long-term craniopharyngioma survivors with and without hypothalamic involvement or treatment- related damage, recruited in the German Childhood Cra- niopharyngioma Registry, and in 73 healthy controls, attending the Craniopharyngioma Support Group Meeting 2014. Oxytocin was measured in saliva of craniophar- yngioma patients and controls before and after standar- dized breakfast and associations with gender, body mass index, hypothalamic involvement, diabetes insipidus, and irradiation were analyzed. Patients with preoperative hypothalamic involvement showed similar oxytocin levels compared to patients without hypothalamic involvement and controls. However, patients with surgical hypotha- lamic lesions grade 1 (anterior hypothalamic area) pre- sented with lower levels (p = 0.017) of oxytocin under fasting condition compared to patients with surgical lesion of posterior hypothalamic areas (grade 2) and patients without hypothalamic lesions (grade 0). Craniophar- yngioma patients’ changes in oxytocin levels before and after breakfast correlated (p = 0.02) with their body mass index. Craniopharyngioma patients continue to secrete oxytocin, especially when anterior hypothalamic areas are not involved or damaged, but oxytocin shows less varia- tion due to nutrition. Oxytocin supplementation should be explored as a therapeutic option in craniopharyngioma patients with hypothalamic obesity and/or behavioral pathologies due to lesions of specific anterior hypotha- lamic areas. Clinical trial number: KRANIOPHAR- YNGEOM 2000/2007(NCT00258453; NCT01272622). [less ▲]

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See detailHet net en het netwerk. Werkomgevingen van penitentiaire directieteams
Dubois, Christophe ULg; Winant, Ben

in Justice et Sécurité = Justitie en Veiligheid (2016), 7

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See detailMethodik zur schnellen Bewertung von Syntheserouten auf Basis von Exergiebilanzen
Frenzel, Philipp; Pfennig, Andreas ULg

in Chemie Ingenieur Technik (2016), 88(9), 1381

Heutige chemische Produkte basieren fast ausschließlich auf erdölbasierten Rohstoffen. Aufgrund weltweiter Bemühungen, die Abhängigkeit von fossilen Rohstoffen zu reduzieren, wird in den letzten Jahren ... [more ▼]

Heutige chemische Produkte basieren fast ausschließlich auf erdölbasierten Rohstoffen. Aufgrund weltweiter Bemühungen, die Abhängigkeit von fossilen Rohstoffen zu reduzieren, wird in den letzten Jahren verstärkt die Nutzung alternativer Kohlenstoffquellen wie Biomasse oder CO2 erforscht. Die alternativen Kohlenstoffquellen unterscheiden sich hinsichtlich ihrer Zusammensetzung und Stoffeigenschaften teilweise deutlich von fossilen Rohstoffen. Aus diesem Grund müssen Syntheserouten und darauf aufbauende Prozesse neu entwickelt werden. Da zum einen sehr viele Syntheserouten prinzipiell denkbar sind und zum anderen die Entwicklung der entsprechenden Prozesse aufwendig ist, wird eine Möglichkeit benötigt, begrenzte Entwicklungsressourcen sinnvoll zu steuern. Dazu sollte bereits in einem frühen Entwicklungsstadium ein quantitativer Vergleich der Syntheserouten erfolgen, um diejenigen zu identifizieren, die das größte wirtschaftliche Potential versprechen. In diesem Vortrag wird eine Methodik vorgestellt, um eine schnelle erste, auf Exergie basierte Bewertung des wirtschaftlichen Potentials einer Syntheseroute bereits in einem frühen Entwicklungsstadium durchzuführen, in dem nur wenige Informationen vorliegen. Die Idee der Methodik ist, Syntheserouten in standardisierten Prozessen abzubilden, wodurch eine automatisierte Auswertung und somit ein schnelles Screening möglich wird. Die standardisierten Prozesse umfassen sowohl den Einfluss der Reaktion durch Abbildung der Reaktionsbedingungen, Stöchiometrie, Umsatz und Selektivität als auch die Auswirkungen der Trennaufgabe. Ebenso berücksichtigt wird die Rückführung von Lösungsmitteln und ggf. nicht umgesetzten Edukten. Als zentrale Bewertungsgröße zur Abschätzung des wirtschaftlichen Potentials wird eine Kombination aus Exergie- und Rohstoffeinsatz herangezogen. Der Vorteil von Exergiebilanzen gegenüber Energiebilanzen ist, dass die Produktion von Entropie berücksichtigt wird und so die Auswirkungen einzelner Prozessschritte untersucht und zwischen verschiedenen Energieformen unterschieden werden kann. Durch Berechnung der Exergieverluste, also der Verluste von Exergie aufgrund von Entropieerzeugung in den Prozessen, ergibt sich ein quantitativer Vergleich verschiedener Syntheserouten. [less ▲]

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See detailWork–Home Interface and Well-Being: A Cross-Lagged Analysis
Babic, Audrey ULg; Stinglhamber, Florence; Bertrand, Françoise ULg et al

in Journal of Personnel Psychology (2016)

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See detailThe Case : Acute renal failure and refractory hyponatremia
denis, Chloé; JADOT, Virginie ULg; BOUQUEGNEAU, Antoine ULg et al

in Kidney International (2016), 90

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See detailHousing Quality as Environmental Inequality: The Case of Wallonia, Belgium
Lejeune, Zoé ULg; Xhignesse, Guillaume ULg; Kryvobokov, Marko et al

in Journal of Housing and the Built Environment (2016), 31(3), 495-512

First in the USA and then in many other countries, scholarship on environmental inequality has sought to shed light on the unequal environmental conditions borne by poor people and ethnic minorities, and ... [more ▼]

First in the USA and then in many other countries, scholarship on environmental inequality has sought to shed light on the unequal environmental conditions borne by poor people and ethnic minorities, and to challenge public policies and their unjust impacts on those target groups. Housing quality, especially the indoor characteristics of homes, offers an innovative perspective in this field of research. In previous research on environmental inequality in the Walloon context, housing quality has been proven to be a major determinant of quality of life and environmental well-being. This paper analyses housing quality through a twofold approach: through indoor characteristics on the one hand, and outdoor subjective and objective externalities on the other. It reveals the disparities between the most deprived and the wealthiest segments of the population. The evidence for this study is based on a housing quality survey carried out in 2012 and 2013 on 6,018 households in Wallonia (Belgium). The key findings are that poor people are found to live in housing of lower quality, in densely populated neighbourhoods and those with mixed use, with compensating amenities provided at the local level. Moreover, consistent with environmental inequality scholarship, deprived households are found to bear the burden of environmental degradation outside the home. People live in areas with poorer air quality, but are found to benefit from greater access to green spaces. The results of the survey reveal an interesting point concerning the environmental inequality literature; the interior features of housing are found to differ more widely between deprived and wealthier people than the surrounding environment does. [less ▲]

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See detailCollaborative 3D Modeling: Conceptual and Technical Issues
Hajji, Rafika; Billen, Roland ULg

in International Journal of 3-D Information Modeling (IJ3DIM) (2016), 5(3), 47-67

The need of 3D city models increases day by day. However, 3D modeling still faces some impediments to be generalized. Therefore, new solutions such as collaboration should be investigated. The paper ... [more ▼]

The need of 3D city models increases day by day. However, 3D modeling still faces some impediments to be generalized. Therefore, new solutions such as collaboration should be investigated. The paper presents a new vision of collaboration applied on 3D modeling through the definition of the concept of a 3D collaborative model. The paper highlights basic questions to be considered for the definition and the development of that model then argues the importance of reuse of 2D data as a promising solution to reconstruct 3D data and to upgrade to integrated 3D solutions in the future. This idea is supported by a case study, to demonstrate how 2D/2.5D data collected from different providers in Walloon region in Belgium can be integrated and reengineered to match the specifications of a 3D building model compatible with the CityGML standard. [less ▲]

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See detailL’administration Obama, a t-elle (vraiment) navigué à vue sur la scène mondiale ?
Santander, Sébastian ULg

in Recherches internationales (2016), 106

Dès son arrivée au pouvoir, Obama a pris le soin de tenir un discours de rupture avec son prédécesseur dont l’action interventionniste et belliqueuse avait terni l’image des ÉU dans le monde. Il a sous ... [more ▼]

Dès son arrivée au pouvoir, Obama a pris le soin de tenir un discours de rupture avec son prédécesseur dont l’action interventionniste et belliqueuse avait terni l’image des ÉU dans le monde. Il a sous-entendu qu’il ne se laisserait pas enfermer dans des cadres idéologiques et qu’il privilégierait une approche « pragmatique » et « souple », et fait savoir qu’il n’engagerait plus les ÉU dans des opérations militaires de grande envergure. Ce discours d’une approche au cas par cas combiné à la politique du retrait militaire d’Irak et d’Afghanistan, et au fait que Obama a parfois été amené à adopter une attitude réactive pour répondre aux soubresauts de l’actualité internationale ont alimenté la perception dominante selon laquelle cette administration se désintéressait et se désengageait du monde, et déployait une politique étrangère marquée par l’indécision, l’improvisation et l’absence de vision à long terme. On ne peut omettre que cette administration a parfois du adapter et ajuster sa politique en fonction des événements internationaux. Faut-il pour autant conclure que sous Obama la première puissance mondiale a navigué à vue sur la scène internationale ? [less ▲]

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See detailContingence et nécessité chez Hegel et Spinoza
Lejeune, Guillaume ULg

in Studia Hegeliana (2016)

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See detailMacro-economic factors influencing the architectural business model shift in the pharmaceutical industry
Dierks, Raphaela Marie Louisa ULg; Bruyère, Olivier ULg; Reginster, Jean-Yves ULg et al

in Expert Review of Pharmacoeconomics & Outcomes Research (2016), First online

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its ... [more ▼]

Introduction: Technological innovations, new regulations, increasing costs of drug productions and new demands are only few key drivers of a projected alternation in the pharmaceutical industry and its underlying business model. Despite significant articles in the press, there is little medical and economic evidence on the rationale driving the transformation from the traditional Research & Development (R&D) model to new alternative business models, such as Mergers & Acquisitions (M&A). The purpose of this review is to understand the macro-economic factors responsible for the revolution of the pharmaceutical business model, by understanding the needs, desires, new behavioral patterns, but also challenges within the industry. Considering these changes will be the key to possessing a competitive advantage over the market players. Areas covered: Existing literature on new macro-economic factors changing the pharmaceutical landscape has been reviewed to present a clear image of the current market environment. Expert commentary: Literature and media sources show that pharmaceutical companies are facing an architectural alteration in their business model, with more M&A deals and collaborations headlining the papers. Although Q1 2016 did show a major slowdown in M&A deals by volume since 2013 (with deal cancellations of Pfizer and Allergan, or the downfall of Valeant) pharmaceutical analysts remain confident that this shortfall was a consequence of the equity market volatility. It seems likely that the shift to an M&A model will become apparent during the remainder of 2016, with deal announcements such as Abbott Laboratories, AbbVie and Sanofi worth USD 45billion [1] showing the appetite of big pharma companies to shift from the fully vertical integrated business model to more horizontal business models. [less ▲]

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See detailA combined transmission spectrum of the Earth-sized exoplanets TRAPPIST-1 b and c
de Wit, Julien; Wakeford, Hannah R.; Gillon, Michaël ULg et al

in Nature (2016), 537

Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1 (ref. 3). The nature of these planets has yet to be determined, as their ... [more ▼]

Three Earth-sized exoplanets were recently discovered close to the habitable zone of the nearby ultracool dwarf star TRAPPIST-1 (ref. 3). The nature of these planets has yet to be determined, as their masses remain unmeasured and no observational constraint is available for the planetary population surrounding ultracool dwarfs, of which the TRAPPIST-1 planets are the first transiting example. Theoretical predictions span the entire atmospheric range, from depleted to extended hydrogen-dominated atmospheres. Here we report observations of the combined transmission spectrum of the two inner planets during their simultaneous transits on 4 May 2016. The lack of features in the combined spectrum rules out cloud-free hydrogen-dominated atmospheres for each planet at ≥10σ levels; TRAPPIST-1 b and c are therefore unlikely to have an extended gas envelope as they occupy a region of parameter space in which high-altitude cloud/haze formation is not expected to be significant for hydrogen-dominated atmospheres. Many denser atmospheres remain consistent with the featureless transmission spectrum—from a cloud-free water-vapour atmosphere to a Venus-like one. [less ▲]

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See detailDetermination of iohexol and iothalamate in serum and urine by capillary electrophoresis.
Van Houcke, Sofie K.; Seaux, Liesbeth; Cavalier, Etienne ULg et al

in Electrophoresis (2016)

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or ... [more ▼]

Estimation of glomerular filtration rate (eGFR) is essential to assess kidney function. Iodine containing contrast agents detection by HPLC has been proposed as a safe alternative for inulin or radioactive compounds. However, HPLC is a time-consuming and labour-intensive method. The aim of this study was to develop an assay for iohexol and iothalamate using capillary electrophoresis (CE). Iohexol and iothalamate were directly analysed by CE in serum and urine, using photometric detection (246 nm). Serum peak height was proportional to iohexol and iothalamate concentrations. Detection limits for iohexol and iothalamate were 10 mg/L and 5 mg/L. Limits of quantification were 13.0 mg/L and 15.0 mg/L. Within-run CVs were 4.9% and 6.5%; between-run CVs 3.1-9.9% and 3.8-13.7%. A good correlation was observed between CE and HPLC: y = 1.1703 x + 5.017 (iohexol) and y = 0.7807 x + 11.01 (iothalamate) [y = concentration obtained by CE (mg/L), x = concentration obtained by HPLC (mg/L)]. In addition, CE allowed to determine urinary iohexol concentration. Although the detection limit for CE was higher than for HPLC, CE can still be used for eGFR determination. Advantages of this high throughput method are the absence of sample pretreatment and a minimal sample volume requirement. This article is protected by copyright. All rights reserved. [less ▲]

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See detailUsing a structural root system model for an in-depth assessment of root image analysis pipeline
Lobet, Guillaume ULg; Koevoets, Iko; Tocquin, Pierre ULg et al

in bioRxiv (2016)

Root system analysis is a complex task, often performed using fully automated image analysis pipelines. However, these pipelines are usually evaluated with a limited number of ground-truth root images ... [more ▼]

Root system analysis is a complex task, often performed using fully automated image analysis pipelines. However, these pipelines are usually evaluated with a limited number of ground-truth root images, most likely of limited size and complexity. We have used a root model, ArchiSimple to create a large and diverse library of ground-truth root system images (10.000). This library was used to evaluate the accuracy and usefulness of several image descriptors classicaly used in root image analysis pipelines. Our analysis highlighted that the accuracy of the different metrics is strongly linked to the type of root system analyzed (e.g. dicot or monocot) as well as their size and complexity. Metrics that have been shown to be accurate for small dicot root systems might fail for large dicots root systems or small monocot root systems. Our study also demonstrated that the usefulness of the different metrics when trying to discriminate genotypes or experimental conditions may vary. Overall, our analysis is a call to caution when automatically analyzing root images. If a thorough calibration is not performed on the dataset of interest, unexpected errors might arise, especially for large and complex root images. To facilitate such calibration, both the image library and the different codes used in the study have been made available to the community. [less ▲]

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See detailUnusual Species of Dermatophytes: Rarely Identified or New?
HAYETTE, Marie-Pierre ULg; SACHELI, Rosalie ULg

in Mycopathologia (2016)

Dermatophytes are causing superficial mycosis in animals and humans. Depending on the geophilic, zoophilic or anthropophilic origin of the fungus but also on the immunological status of the patient ... [more ▼]

Dermatophytes are causing superficial mycosis in animals and humans. Depending on the geophilic, zoophilic or anthropophilic origin of the fungus but also on the immunological status of the patient, symptomatology can widely differ. Nevertheless, each species is currently associated with typical clinical manifestations, even if atypical localizations and/or clinical pictures are sometimes also reported. Diagnostic tools applied to species identification have been changing since the last two decades with the more frequent use of molecular methods currently considered nowadays as reference methods for species identification. It becomes obvious that the algorithm used for the distinction of closely related species needs to combine phenotypic and genomic methods. All these different points are discussed, and the most recent novel species causing or involved in human dermatophytosis are reported. [less ▲]

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See detailLa vignette diagnostique de l’étudiant Mise au point d’une suspicion de malaise hypoglycémique chez une personne adulte non diabétique
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LEFEBVRE, Pierre ULg

in Revue Médicale de Liège (2016), 71(09), 407-413

Résumé : La survenue de malaises est souvent attribuée à une hypoglycémie chez des personnes non diabétiques et, a priori, sans autre problème de santé. Ce diagnostic est, cependant, souvent galvaudé, car ... [more ▼]

Résumé : La survenue de malaises est souvent attribuée à une hypoglycémie chez des personnes non diabétiques et, a priori, sans autre problème de santé. Ce diagnostic est, cependant, souvent galvaudé, car habituellement non clairement démontré. Le diagnostic d’hypoglycémie doit se faire de façon structurée en se basant sur la triade de Whipple. Tout d’abord, l’anamnèse doit rechercher les symptômes évocateurs d’hypoglycémie, adrénergiques et neuroglucopéniques. Ensuite, l’hypoglycémie doit être authentifiée par une mesure d’une valeur basse au moment d’un malaise. Enfin, s’il s’agit bien d’une hypoglycémie, le malaise doit disparaître rapidement après resucrage. Une fois le diagnostic posé sur la base de cette triade, l’anamnèse doit faire préciser, outre la sévérité des malaises, leur chronologie, après les repas ou à jeun, ce qui oriente vers une hypoglycémie réactive, fonctionnelle, ou vers une hypoglycémie d’origine organique (insulinome). Des examens complémentaires, faisant d’abord appel à la biologie clinique, ensuite éventuellement à l’imagerie médicale, permettront de, non seulement confirmer le diagnostic d’hypoglycémie, mais aussi d’en préciser l’origine, ce qui orientera la stratégie thérapeutique. [less ▲]

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See detailThe cardiovascular impact of intense eccentric isokinetic exercise versus aerobic treadmill running
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; LAURENT, Terry ULg et al

in Isokinetics & Exercise Science (2016), 24(3), 201-208

BACKGROUND: Regular physical activity is an important health factor, but intense physical stress can increase the risk of heart disease. OBJECTIVE: Our aim was to determine the potential cardiac ... [more ▼]

BACKGROUND: Regular physical activity is an important health factor, but intense physical stress can increase the risk of heart disease. OBJECTIVE: Our aim was to determine the potential cardiac repercussions of, and the oxidative stress resulting from a maximal eccentric isokinetic exercise and a 1-hour treadmill run at 75% ˙V O2 max (maximal exercise done 6 weeks before). METHODS: Twelve young sedentary healthy subjects randomly performed two tests separated by 6 weeks: 1) 3 sets of 30 maximal eccentric isokinetic contractions of the quadriceps; 2) a 1-hour running on treadmill at 75% ˙V O2 max. We drew blood samples just before each exercise (T1), and just after (T2), 3 hours after (T3), and 24 hours after (T4) the end of each exercise to measure cardiac and oxidative stress biomarkers. RESULTS: In the running group, we observed significant differences for myoglobin (T3: 145 ± 80 μg/L), creatinine kinase (T4: 593 ± 350 mg/L), oxidized glutathione (T2: 22 ± 15.6 μmol/L), and highly sensitive cardiac troponin T, (T3: 0.051 ± 0.038 ng/mL). In the isokinetic group, we observed significant differences for myoglobin (T3:1419 ± 2533 mg/L), creatine kinase (3303 ± 7159 mg/L), and oxidized glutathione (T4:24 ± 14 μmol/L). Between isokinetic exercise and running, we observed significant differences for uric acid (p < 0.05, running > eccentric), myoglobin (p < 0.05, ditto), NT-proBNP (p < 0.05, ditto), hsTnT (p < 0.01, ditto), and oxidized glutathione (p < 0.05). CONCLUSIONS: As cardiac biomarkers appear practically unmodified after the isokinetic exercise, despite the considerable oxidative stress, we suggest that the application of intense maximal eccentric isokinetic exercise, when indicated, should be safe for most patients including those whose cardiac status is unknown. On the other hand, the increase in cardiac biomarkers observed after running, could reflect leakage of these biomarkers from the cytosolic pool of cardiac cells, linked to membrane damage, rather than the result of a major injury and hence running is supposed to be a safe practice. However, since sudden death during running has been previously described, assesment of the cardiac biomarkers and a follow-up by a sport doctor is important especially if there is a cardiac family history. [less ▲]

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See detailCutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients
Jurczyszyn, A.; Olszewska-Szopa, M.; Hungria, V. et al

in Leukemia & Lymphoma (2016), 57(9 2071-6), 2071-6

Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical ... [more ▼]

Skin infiltration in multiple myeloma (skin MM) is a rare clinical problem. Only a few cases of skin involvement have been reported, primarily in single case reports. We analyzed and present the clinical outcomes, immunohistochemistry and cytogenetic features, and relevant laboratory data on 53 biopsy-proven skin MM cases. The median time from MM diagnosis to skin involvement was 2 years. There appears to be an overrepresentation of immunoglobulin class A (IgA) and light chain disease in skin MM. We found no correlation between CD56 negative MM and skin infiltration. We found that skin MM patients presented in all MM stages (i.e. ISS stages I to III), and there was no preferential cytogenetic abnormality. Patients with skin MM carry a very poor prognosis with a median overall survival (OS) of 8.5 months as time from skin involvement. Moreover, patients with IgA disease and plasmablastic morphology appear to have a worse OS. [less ▲]

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See detailFire Performance of Columns made of Normal and High Strength Concrete: A Comparative Analysis
Gernay, Thomas ULg

in Key Engineering Materials (2016), 711

The use of high strength concrete (HSC) in multi-story buildings has become increasingly popular. Selection of HSC over normal strength concrete (NSC) allows for reducing the dimensions of the columns ... [more ▼]

The use of high strength concrete (HSC) in multi-story buildings has become increasingly popular. Selection of HSC over normal strength concrete (NSC) allows for reducing the dimensions of the columns sections. However, this reduction has consequences on the structural performance in case of fire, as smaller cross sections lead to faster temperature increase in the section core. Besides, HSC experiences higher rates of strength loss with temperature and a higher susceptibility to spalling than NSC. The fire performance of a column can thus be affected by selecting HSC over NSC. This research performs a comparison of the fire performance of HSC and NSC columns, based on numerical simulations by finite element method. The thermal and structural analyses of the columns are conducted with the software SAFIR®. The variation of concrete strength with temperature for the different concrete classes is adopted from Eurocode. Different configurations are compared, including columns with the same load bearing capacity and columns with the same cross section. The relative loss of load bearing capacity during the fire is found to be more pronounced for HSC columns than for NSC columns. The impact on fire resistance rating is discussed. These results suggest that consideration of fire loading limits the opportunities for use of HSC, especially when the objective is to reduce the dimensions of the columns sections. [less ▲]

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See detailEtat de la contraception en 2016
Manigart, Yannick; BELIARD, Aude ULg; Rozenberg, Serge et al

in Revue Médicale de Bruxelles (2016), 37

Introduction: The Pill and and other forms of hormonal contraception, if taken correctly, are very effective and safe for millions of women, but since a few years, due to debates and controversies about ... [more ▼]

Introduction: The Pill and and other forms of hormonal contraception, if taken correctly, are very effective and safe for millions of women, but since a few years, due to debates and controversies about third- and fourth-generation pills, other options have gained in popularity. Objectives: to provide a review of oestroprogestative contraception (OP), progestative contraception, IUDs with a focus on their advantages and side-effects according to the specific needs of women.Methods: Literature review and lessons learned from clinical practice.Results: the importance of family and individual history, the life-style and socio-economic conditions are critical factors for advising women of the 15 contraceptive choices available to them. The risk/benefit ratio of OP contraception needs a yearly follow-up. The progestative contraception is the preferred option for women who have contraindication for estrogen, are older than forty, and/or have risk factors such as a history of venous thromboembolism, overweight and smoking. The IUD is well tolerated and causes few side effects. Among the other contraceptive methods, sterilization and diaphragms are briefly discussed. Conclusions: Among the many safe and effective contraceptive methods, it is important for general practitioners to know the advantages and the side effects of each method, as well as the specific conditions of the woman, to propose the best options available. In case of difficulties of follow up or adherence to daily uptake, in particular among adolescents, long-acting methods such as IUD or implants are preferable. [less ▲]

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See detailL'âge de début de l'obligation scolaire
Behrendt, Christian ULg

in Revue Belge de Droit Constitutionnel (2016), 2016

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See detailDiurnal variations of hormonal secretion, alertness and cognition in extreme chronotypes under different lighting conditions.
Maierova, L.; Borisuit, A.; Scartezzini, L et al

in Scientific Reports (2016)

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See detailEffect of citrate anticoagulation on CO2 extraction during low flow extracorporeal veno-venous CO2 removal therapy
MORIMONT, Philippe ULg; Habran, Simon ULg; Hubert, Romain et al

in Intensive Care Medicine Experimental (2016), 4

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See detailLa responsabilité du supérieur hiérarchique devant la Cour pénale internationale : une première synthèse à la lumière du jugement prononcé dans l’affaire Bemba
Wery, Marine ULg; Deprez, Christophe ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 2

Le 21 mars 2016, au terme d’une procédure longue de huit années, la Cour pénale internationale (CPI) prononça un verdict de culpabilité à l’encontre de Jean-Pierre Bemba. L’une des innovations majeures ... [more ▼]

Le 21 mars 2016, au terme d’une procédure longue de huit années, la Cour pénale internationale (CPI) prononça un verdict de culpabilité à l’encontre de Jean-Pierre Bemba. L’une des innovations majeures liées à cette affaire concerne le vecteur d’imputabilité mobilisé par les juges. Pour la première fois dans l’histoire de la CPI, une chambre de première instance s’est dégagée des modes traditionnels de responsabilité prévus à l’article 25 du Statut de Rome pour sceller le sort d’un accusé sur la base de l’article 28 du même instrument, en application duquel la responsabilité pénale d’un supérieur hiérarchique peut être mise en cause en lien avec les actes commis par ses subordonnés. Par cette contribution, nous proposons d’examiner le verdict du 21 mars 2016, mais aussi les quelques pistes jurisprudentielles préexistantes, afin d’ébaucher une première synthèse du mécanisme de responsabilité du supérieur hiérarchique devant la CPI. [less ▲]

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See detailLes Nouveaux Liégeois. Migrations et Transformations Urbaines
Lafleur, Jean-Michel ULg; Stangherlin, Gregor

in Dérivations (2016), (3), 194-203

Dans cet article, nous proposons de discuter la migration contemporaine sur le territoire de la Ville de Liège. Cette discussion repose pour l’essentiel sur une analyse des données statistiques ... [more ▼]

Dans cet article, nous proposons de discuter la migration contemporaine sur le territoire de la Ville de Liège. Cette discussion repose pour l’essentiel sur une analyse des données statistiques disponibles et une revue de la littérature scientifique produite sur les migrations à Liège ces dernières années. Nous commençons donc par une description des grandes évolutions démographiques sur le territoire de la ville depuis 1991 pour insister ensuite sur les effets de la migration dans cinq quartiers de la ville. Cette première partie souligne le rôle essentiel que joue la migration dans la croissance démographique observée ces dix dernières années à Liège. Ensuite, nous examinons la présence étrangère sur le territoire de la ville selon les 5 dimensions fréquemment citées dans les débats sur l’intégration des populations étrangères : emploi, logement, éducation, socio-culturelle et politique. [less ▲]

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See detailBiocompatibility of polymer-infiltrated-ceramic-network (PICN) materials with Human Gingival Fibroblasts (HGFs).
GRENADE, Charlotte ULg; De Pauw-Gillet, Marie-Claire ULg; Gailly, Patrick ULg et al

in Dental materials : official publication of the Academy of Dental Materials (2016), 32(9), 1152-1164

OBJECTIVES: Polymer-infiltrated-ceramic-network (PICN) materials constitute an innovative class of CAD-CAM materials offering promising perspectives in prosthodontics, but no data are available in the ... [more ▼]

OBJECTIVES: Polymer-infiltrated-ceramic-network (PICN) materials constitute an innovative class of CAD-CAM materials offering promising perspectives in prosthodontics, but no data are available in the literature regarding their biological properties. The objective of the present study was to evaluate the in vitro biocompatibility of PICNs with human gingival fibroblasts (HGFs) in comparison with materials typically used for implant prostheses and abutments. METHODS: HGF attachment, proliferation and spreading on discs made of PICN, grade V titanium (Ti), yttrium zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control), were evaluated using a specific insert-based culture system (IBS-R). Sample surface properties were characterized by XPS, contact angle measurement, profilometry and SEM. RESULTS: Ti and Zi gave the best results regarding HGF viability, morphology, number and coverage increase with time in comparison with the negative control, while PICN and eM gave intermediate results, cell spreading being comparable for PICN, Ti, Zi and eM. Despite the presence of polymers and their related hydrophobicity, PICN exhibited comparable results to glass-ceramic materials, which could be explained by the mode of polymerization of the monomers. SIGNIFICANCE: The results of the present study confirm that the currently employed materials, i.e. Ti and Zi, can be considered to be the gold standard of materials in terms of HGF behavior, while PICN gave intermediate results comparable to eM. The impact of the present in vitro results needs to be further investigated clinically, particularly in the view of the utilization of PICNs for prostheses on bone-level implants. [less ▲]

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See detailCircadian dynamics in measures of cortical excitation and inhibition balance
Chellappa, Sarah; Gaggioni, Giulia ULg; LY, Julien ULg et al

in Scientific Reports (2016), 6:33661

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See detailComment j'explore... une dysmorphose dento-maxillo-faciale.
Urbain, Valérie; GILON, Yves ULg; BRUWIER, Annick ULg et al

in Revue Médicale de Liège (2016), 71(9), 394-399

Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by ... [more ▼]

Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by variations in the food and society habits.We will first discuss the various causes (congenital and environnemental) and the pathophysiology of these disorders. Then, we will separate them according to the skeletal and Angle’s classifications. We will examine the predictive criteria of these dysmorphoses from the youngest age and consider their clinical and cephalometrical diagnosis We will envisage their functional and aesthetic consequences and expose the preventive options. Finally, we will describe the orthodontic and surgical treatment available today and conclude that surgery remains the gold standard by restoring the conventional axis. [less ▲]

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See detailAlterations of circulating lymphoid committed progenitor cellular metabolism after allogeneic stem cell transplantation in humans
GLAUZY; PEFFAULT DE LATOUR; ANDRE-SCHMUTZ et al

in Experimental Hematology (2016), 44(9), 811-816

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See detailProtection cardiovasculaire et rénale du patient diabétique de type 2 : le point après EMPA-REG OUTCOME et LEADER
SCHEEN, André ULg; PIERARD, Luc ULg; KRZESINSKI, Jean-Marie ULg et al

in Revue Médicale de Liège (2016), 71(09), 376-381

Summary : Type 2 diabetes (T2D), often associated with arterial hypertension, represents a high risk of cardiovascular disease and nephropathy. Two clinical trials demonstrate the superiority versus a ... [more ▼]

Summary : Type 2 diabetes (T2D), often associated with arterial hypertension, represents a high risk of cardiovascular disease and nephropathy. Two clinical trials demonstrate the superiority versus a placebo of two antidiabetic drugs in patients with T2D and high cardiovascular risk : empagliflozin, an inhibitor of sodium-glucose type 2 (SGLT2) cotransporters, in EMPA-REG OUTCOME and liraglutide, an agonist of glucagon-like peptide-1 (GLP-1) receptors, in LEADER. Both medications showed a significant reduction in major cardiovascular events (-14 and -13 %, respectively), cardiovascular mortality (-38 and -22%), all-cause mortality (-32 and -15 %) and renal events (-39 et -22 %). The underlying protective mechanisms remain controverted. Ongoing studies should allow to decide whether the benefits are specific to each molecule or may be attributed to a class effect. [less ▲]

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See detailL'EBM peut-elle encore enthousiasmer ?
Henrard, Gilles ULg

in Minerva: Tijdschrift Voor Evidence Based Medicine (2016)

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See detail« Oiseaux blessés. Avec les stagiaires d’Article 23 »
Melice, Anne ULg

in Centre Franco Basaglia – Liège, Mouvement pour une psychiatrie démocratique dans le milieu de vie. (2016)

Après une synthèse de récits de vie recueillis auprès de stagiaires rencontrés au sein des ateliers de l’Asbl Article 23 (Horeca et Bâtiment), ce texte décrit l’accueil qu’ils m’y ont réservé. Ce récit se ... [more ▼]

Après une synthèse de récits de vie recueillis auprès de stagiaires rencontrés au sein des ateliers de l’Asbl Article 23 (Horeca et Bâtiment), ce texte décrit l’accueil qu’ils m’y ont réservé. Ce récit se prolongera dans le texte suivant intitulé « ‘’Je te porte dans moi comme un oiseau blessé’’ (Aragon) », qui se fera l’écho de mon observation de l’hospitalité propre aux ateliers d’Article 23. [less ▲]

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See detailGalileo Cycle-Slip Detection. How Four Frequencies Help When the Ionosphere Is Disturbed.
Van de Vyvere, Laura; Warnant, René ULg

in GPS World (2016), 27(9), 50-56

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See detailRelation entre hygiène bucco-dentaire et tendinopathies chez les sportifs
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Science & Sports (2016), 31(4), 227-229

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See detailInvasive and Non-invasive Electrical Pericranial Nerve Stimulation for the Treatment of Chronic Primary Headaches
D'Ostilio, Kevin ULg; MAGIS, Delphine ULg

in Current Pain and Headache Reports (2016), 20

Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can ... [more ▼]

Chronic primary headaches are widespread disorders which cause significant quality of life and socioprofessional impairment. Available pharmacological treatments have often a limited efficacy and/or can generate unbearable side effects. Electrical nerve stimulation is a well known non-destructive method of pain modulation which has been recently applied to headache management. In this review, we summarise recent advances in invasive and non-invasive neurostimulation techniques targeting pericranial structures for the treatment of chronic primary headaches, chiefly migraine and cluster headache: occipital nerve, supraorbital nerve, vagus nerve, and sphenopalatineganglion stimulations. Invasive neurostimulation therapies have offered a new hope to drug-refractory headache sufferers but are not riskless and should be proposed only to chronic patients who failed to respond to most existing preventives. Non-invasive neurostimulation devices are user-friendly, safe and well tolerated and are thus taking an increasing place in the multidisciplinary therapeutical armamentarium of primary headaches. [less ▲]

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See detailAlligator Records- 45è anniversaire-Interview Bruce Iglauer
Sacré, Robert ULg

in ABS Magazine (2016), (51), 8-17

Alligator Records (Chicago,IL.) 45 ans au service du Blues

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See detailDu processus aux soins intégrés: Expérience de gestion de projet bottom-up
ERPICUM, Marie ULg; BASSLEER, Bernard ULg; DEFRAIGNE, Jean ULg et al

in Gestions Hospitalieres (2016), 558(Août/septembre 2016),

Le service de chirurgie cardiaque du CHU de Liège a soutenu des recherches visant à développer un programme d’épargne sanguine, enjeu actuel de taille dans ce secteur des soins de santé. Ce projet a ... [more ▼]

Le service de chirurgie cardiaque du CHU de Liège a soutenu des recherches visant à développer un programme d’épargne sanguine, enjeu actuel de taille dans ce secteur des soins de santé. Ce projet a évolué vers la création d’un itinéraire clinique chirurgical cardiaque et d’un modèle institutionnel pour le développement d’autres itinéraires cliniques. Une évolution qui permet de déterminer les missions spécifiques de l’institution et ses objectifs stratégiques, et de s’associer aux projets nationaux. L’adhésion multidisciplinaire, soutenue par un leadership médical et infirmier, ainsi que la reconnaissance institutionnelle sont les déterminants de la pérennité de cette démarche bottom-up. [less ▲]

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See detailCooperative spontaneous emission from indistinguishable atoms in arbitrary motional quantum states
Damanet, François ULg; Braun, Daniel; Martin, John ULg

in Physical Review A (2016), 94

We investigate superradiance and subradiance of indistinguishable atoms with quantized motional states, starting with an initial total state that factorizes over the internal and external degrees of ... [more ▼]

We investigate superradiance and subradiance of indistinguishable atoms with quantized motional states, starting with an initial total state that factorizes over the internal and external degrees of freedom of the atoms. Due to the permutational symmetry of the motional state, the cooperative spontaneous emission, governed by a recently derived master equation [F. Damanet et al., Phys. Rev. A 93, 022124 (2016)], depends only on two decay rates γ and γ0 and a single parameter dd describing the dipole-dipole shifts. We solve the dynamics exactly for N = 2 atoms, numerically for up to 30 atoms, and obtain the large-N limit by a mean-field approach. We find that there is a critical difference γ0 − γ that depends on N beyond which superradiance is lost. We show that exact nontrivial dark states (i.e., states other than the ground state with vanishing spontaneous emission) only exist for γ = γ0 and that those states (dark when γ = γ0) are subradiant when γ < γ0. [less ▲]

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See detailLa Paméla de Voltaire des Lumières au XXIe siècle - changements de statut et réception générique du texte
Daubercies, Laurence ULg

in Loxias : Littératures Française et Comparées (2016)

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See detailDetailed characterization of the Late Pleistocene loess sequence stratigraphy of Remicourt (Hesbaye region, Belgium) with cone penetration tests
Delvoie, Simon ULg; Boulvain, Frédéric ULg; Charlier, Robert ULg et al

in Geologica Belgica (2016), 19(3-4), 281-289

Cone penetration tests (CPT) and drilling results are used to characterize the Middle Belgium loess sequence. A two scale study has been realized in the Hesbaye region (Belgium). The study on a regional ... [more ▼]

Cone penetration tests (CPT) and drilling results are used to characterize the Middle Belgium loess sequence. A two scale study has been realized in the Hesbaye region (Belgium). The study on a regional scale was performed along a 18 km long section of the high-speed railway Liège-Brussels. About 230 tests were compiled. Results show the loess thickness is very variable and can locally reach 20 m. Tertiary deposits become continuous and they rapidly thicken from Waremme to the West. The lower surface of the Tertiary deposits is characterized by a 0.3% apparent dipping to the NW. The dipping likely results from the Ardenne Massif uplift. The local scale study focuses on the site of Remicourt located along the high-speed railway. 24 CPT tests have been carried out very close to a series of archaeological trenches. The analysis shows penetrometers are able to define some stratigraphic markers within the loess layer. The most identifiable marker is stratigraphically located around the transition between the Humiferous Complex of Remicourt and the Rocourt Pedocomplex. The lens-shape of the loess ridge is also confirmed by the penetrometers’ interpretation. Furthermore, the 3D morphology of each stratigraphic marker can be estimated. These results offer interesting perspectives for the investigation of the loess sequence related to archaeological applications. [less ▲]

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See detailDu stilus à la plume ... du chapeau. Quelques réflexions sur la notion de style
Houbart, Claudine ULg

in Bruxelles Patrimoines (2016), (18),

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See detailCoopération au service de la construction d'une qualité d'accueil
Pirard, Florence ULg

in Revue [Petite] Enfance (2016), 121

Les débats sur la qualité des lieux d’éducation et d’accueil des jeunes enfants (EAJE) font l’objet de nombreuses publications. S’il n’y a pas de consensus sur ce que recouvre précisément cette notion ... [more ▼]

Les débats sur la qualité des lieux d’éducation et d’accueil des jeunes enfants (EAJE) font l’objet de nombreuses publications. S’il n’y a pas de consensus sur ce que recouvre précisément cette notion polysémique, certaines orientations sont mises en avant par différentes instances internationales, comme l’Organisation de Coopération et de Développement Économique (OCDE, 2001, 2006, 2012, 2015) et l’Union Européenne (2015). Ces publications, à partir d’une consultation d’experts de différents pays et d’une revue de la littérature scientifique (essentiellement anglo-saxonne), soulignent notamment l’importance d’une meilleure accessibilité des services, d’une formation initiale et du développement professionnel continu, des conditions de travail adéquates, de lignes directrices claires inscrites dans un curriculum, d’un système d’évaluation et de monitoring de la qualité et, bien sûr, du soutien indispensable d’une gouvernance qui considère l’enfance comme un investissement plutôt que comme un coût. L’enjeu fondamental serait d’offrir aux enfants et à leurs familles des services de qualité dont les effets bénéfiques ne sont plus à démontrer, particulièrement pour celles en situation de précarité. La réalisation contextualisée de ces orientations générales dans un pays ou une région suppose la mise en place de démarches concertées à chaque niveau de responsabilité d’un système dit compétent (Urban et al., 2011) : individuel, institutionnel, interinstitutionnel et de gouvernance. Elle repose sur des formes de coopération et de participation inscrites dans un fonctionnement démocratique qui ne va pas nécessairement de soi. Notre article propose d’interroger ces formes de coopération et de participation attendues, de pointer une série d’obstacles à leur réalisation qu’il s’agit de parvenir à dépasser, mais aussi de relater des expériences qui témoignent d’un autre possible. Il s’appuie sur une revue de la littérature, mais se nourrit aussi des multiples rencontres que notre expérience professionnelle nous a permis de vivre dans différents contextes. [less ▲]

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See detailInteraction of Avibactam with Class B Metallo-β-Lactamases.
Abboud, MI; Damblon, Christian ULg; Brem, J et al

in Antimicrobial Agents and Chemotherapy (2016), 60

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See detailValidation of Prediction Models for Near Adult Height in Children with Idiopathic Growth Hormone Deficiency Treated with Growth Hormone A Belgian Registry Study
Straetemans, Saartje; De Schepper, Jean; THOMAS, Muriel et al

in Hormone Research in Paediatrics (2016), 86

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See detail"Je te porte dans moi comme un oiseau blessé" (Louis Aragon)
Melice, Anne ULg

in Centre Franco Basaglia, Mouvement pour une psychiatrie démocratique dans le milieu de vie (2016)

Dans le sillage du texte précédent « Oiseaux blessés. Avec les stagiaires d’Article 23 », ce texte-ci rend compte des spécificités de l’hospitalité que j’ai observées. Ces spécificités s’éclairent à mes ... [more ▼]

Dans le sillage du texte précédent « Oiseaux blessés. Avec les stagiaires d’Article 23 », ce texte-ci rend compte des spécificités de l’hospitalité que j’ai observées. Ces spécificités s’éclairent à mes yeux des problématiques du don et du contre-don, du « care », des relations à plaisanterie. Enfin, le respect des singularités et des limites individuelles, ainsi que la mise en suspens des rapports concurrentiels constitutifs du monde de travail, dessinent un espace alternatif à l’égard de ce dernier. [less ▲]

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See detailLes usages des manuels dans les préparations des enseignants stagiaires
Scheepers, Caroline ULg

in Français Aujourd'Hui (Le) (2016), 194

La présente contribution se propose d’analyser la façon dont les manuels sont convoqués par les stagiaires dans leurs préparations de cours de français. Dès lors, la focalisation se place non sur les ... [more ▼]

La présente contribution se propose d’analyser la façon dont les manuels sont convoqués par les stagiaires dans leurs préparations de cours de français. Dès lors, la focalisation se place non sur les manuels en tant quel tels, mais sur leur réception et leur réinvestissement dans les pratiques des étudiants. Ont été analysées une centaine de fiches de préparation élaborées par de futurs enseignants belges, qu’ils se destinent à enseigner au primaire, au secondaire inférieur (collège) ou supérieur (lycée). Les usages du manuel révèlent et construisent des différences notables en terme de compétences enseignées, de gestes pédagogiques mobilisés, de rapport au savoir, de culture professionnelle, de formation… Étudier la réception et l’utilisation du manuel revient à problématiser des pratiques et des représentations fondamentales qui touchent à ce que veulent dire enseigner, (faire) apprendre ou construire une leçon. Cette recherche éclaire une facette du processus de planification des apprentissages. [less ▲]

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See detailVisual and auditory cortical evoked potentials in interictal episodic migraine: An audit on 624 patients from three centres.
Ambrosini, Anna; Kisialou, A; Coppola, Gianluca et al

in Cephalalgia : An International Journal of Headache (2016)

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See detailLe décret décumul et le Parlement wallon
Grandjean, Geoffrey ULg; Janssens, Frédéric

in Administration Publique: Revue du Droit Public et des Sciences Administratives (2016), 2

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See detailWill climate change affect insect pheromonal communication?
Boullis, Antoine ULg; Detrain, Claire; Francis, Frédéric ULg et al

in Current Opinion in Insect Science (2016)

Understanding how climate change will affect species interactions is a challenge for all branches of ecology. We have only limited understanding of how increasing temperature and atmospheric CO2 and O3 ... [more ▼]

Understanding how climate change will affect species interactions is a challenge for all branches of ecology. We have only limited understanding of how increasing temperature and atmospheric CO2 and O3 levels will affect pheromone-mediated communication among insects. Based on the existing literature, we suggest that the entire process of pheromonal communication, from production to behavioural response, is likely to be impacted by increases in temperature and modifications to atmospheric CO2 and O3 levels. We argue that insect species relying on long-range chemical signals will be most impacted, because these signals will likely suffer from longer exposure to oxidative gases during dispersal. We provide future directions for research programmes investigating the consequences of climate change on insect pheromonal communication. [less ▲]

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See detailPsychological transition and adjustment processes related to retirement: Influence on cognitive functioning
Grotz, Catherine ULg; Matharan, Fanny; Pérès, Karine et al

in Aging & Mental Health (2016)

Objective: To investigate the relationship between psychological transition and adjustment to retirement and cognitive performances in older adults. Methods: The study’s sample was taken from the Approche ... [more ▼]

Objective: To investigate the relationship between psychological transition and adjustment to retirement and cognitive performances in older adults. Methods: The study’s sample was taken from the Approche Multidisciplinaire Int egr ee cohort, a French prospective study of retirees from agriculture, aged 65 and over, living in rural settings in southwestern France. The cross-sectional analyses were conducted on a sample of 590 elderly people without dementia at baseline and for whom information on perception of the work setting, experience of the retirement transition and adaptation to retirement life (nine variables) as well as neuropsychological measures (global cognitive functioning, episodic memory, verbal fluency, attention and psychomotor speed) were available at first visit. Results: Multivariable linear regression analyses, including nine variables related to retirement and adjusted for potential confounding factors, indicated that three of them positive consideration of former work situation, development of new activities during retirement and good adaptation to free time were associated with better cognitive performances. Conclusions: We found that several factors proved to be determinants of good cognitive functioning at retirement and could serve as a basis for the development of more efficient intervention programs aimed at helping retirees to maintain good cognitive functioning after retirement. [less ▲]

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See detailFertility progression in Germany: an analysis using flexible nonparametric cure survival models
Bremhorst, Vincent; Kreyenfeld, Michaela; Lambert, Philippe ULg

in Demographic Research (2016)

OBJECTIVE This paper uses data from the German Socio-Economic Panel (GSOEP) to study the transition to second and third births. In particular, we seek to distinguish the factors that determine the timing ... [more ▼]

OBJECTIVE This paper uses data from the German Socio-Economic Panel (GSOEP) to study the transition to second and third births. In particular, we seek to distinguish the factors that determine the timing of fertility from the factors that influence ultimate parity progression. METHODS We employ cure survival models, a technique commonly used in epidemiological studies and in the statistical literature but only rarely applied to fertility research. RESULTS We find that education has a different impact on the timing and the ultimate probability of having a second and a third birth. Furthermore, we show that the shape of the fertility schedule for the total population differs from that of ‘susceptible women’ (i.e., those who have a second or a third child). CONCLUSION Standard event history models conflate timing and quantum effects. Our approach overcomes this shortcoming. It estimates separate parameters for the hazard rate of having a next child for the ‘susceptible population’ and the ultimate probability of having another child for the entire population at risk. [less ▲]

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See detailDetermining new threshold temperatures for cooling and heating degree day index of different climatic zones of Iran
Roshan, Gh.R.; Ghanghermeh, A.A.; Attia, Shady ULg

in Renewable Energy : An International Journal (2016), 101(2017), 156-167

Iran is a country with a variety of different climates. Determining the threshold temperatures suitable for providing thermal and climatic comfort is necessary and vital to its population well-being. This ... [more ▼]

Iran is a country with a variety of different climates. Determining the threshold temperatures suitable for providing thermal and climatic comfort is necessary and vital to its population well-being. This research presents new threshold temperatures in order to calculate the degree day index required for heating and cooling by taking advantage of the 12 stations that are representative of the diversity of Iran's climate. Using Olgyay diagram, different bioclimatic ranges of 12 weather stations and their frequencies were compiled, processes and analysed. Mean daily data of temperature and relative humidity were used for the period of 1950e2010. Based on the frequencies of temperature readings falling in Olgyay's diagram comfort zone, representive temperature thresholds were selected based on 40 to 60 percentiles or (P20), 25e75% percentile (P50) and the threshold of 10e90% percentile. The findings of this study shows that Mashhad with 29.6% and Anzali with 2.33% of frequencies, have experienced the maximum and minimum days of comfort. After analyzing various percentiles to determine the threshold temperatures, it was observed that there is a little difference among the stations for determining the minimum threshold for the comfort. Differences are more obvious in the maximum thresholds. In total, minimum base temperatures (HDD) belonged to Ardabil stations that were 20.50, 20.90 and 20 deg C for P20, P50 and P80 respectively. The maximum temperature for calculating CDD with values of (P20 ¼ 25 C; P50 ¼ 26.25 C; P80 ¼ 27.50 C) is dedicated to Zabol station. The findings present more reasonable thermal comfort thresholds that can be used by architects, engineers and policy makers to achieve, in turn, more energy efficient homes and high quality indoor and outdoor living environments. [less ▲]

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See detailAgeism in Belgium and Burundi: A comparative analysis
Marquet, Manon ULg; Missotten, Pierre ULg; Schroyen, Sarah ULg et al

in Clinical Interventions in Aging (2016), 11

Background: Recent cross-cultural comparisons between Asian and Western cultures have shown that ageism arises more from the lack of availability of social and economic resources for older adults than ... [more ▼]

Background: Recent cross-cultural comparisons between Asian and Western cultures have shown that ageism arises more from the lack of availability of social and economic resources for older adults than from the culture itself. We tested this assumption by conducting a survey among people living in a least-developed country compared with a developed country. Methods: Twenty-seven Belgians living in Belgium, 29 Burundians living in Belgium and 32 Burundians living in Burundi were included in this study. Their attitudes toward older adults were assessed using several self-reported measures. Results: Statistical analyses confirmed that older people are more negatively perceived by Burundians living in Burundi than by Burundians and Belgians living in Belgium, whose attitudes did not differ from each other. Conclusion: Consistent with our hypothesis, our results suggest that the level of development of a country and more particularly the lack of government spending on older people (pension and healthcare systems) may contribute to their younger counterparts perceiving them more negatively. [less ▲]

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See detailGraphene-multiferroic interfaces for spintronics applications
Zanolli, Zeila ULg

in Scientific Reports (2016)

Graphene and magnetoelectric multiferroics are promising materials for spintronic devices with high performance and low energy consumption. A very long spin di usion length and high carrier mobility make ... [more ▼]

Graphene and magnetoelectric multiferroics are promising materials for spintronic devices with high performance and low energy consumption. A very long spin di usion length and high carrier mobility make graphene attractive for spintronics. The coupling between ferroelectricity and magnetism, which characterises magnetoelectrics, opens the way towards unique device architectures. In this work, we combine the features of both materials by investigating the interface between graphene and BaMnO3, a magnetoelectric multiferroic. We show that electron charge is transferred across the interface and magnetization is induced in the graphene sheet due to the strong interaction between C and Mn. Depending on the relative orientation of graphene and BaMnO3, a quasi-half-metal or a magnetic semiconductor can be obtained. A remarkably large proximity induced spin splitting of the Dirac cones (~300 meV) is achieved. We also show how doping with acceptors can make the high-mobility region of the electronic bands experimentally accessible. This suggests a series of possible applications in spintronics (e.g. spin filters, spin injectors) for hybrid organic-multiferroic materials and reveals hybrid organic-multiferroics as a new class of materials that may exhibit exotic phenomena such as the quantum anomalous Hall effect and a Rashba spin-orbit induced topological gap. [less ▲]

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See detailSO(10) models with flavour symmetries: Classification and examples
Ivanov, Igor ULg; Lavoura, Luis

in Journal of Physics : G Nuclear & Particle Physics (2016), 43(10), 105005

Renormalizable SO(10) grand unified theory (GUT) models equipped with flavour symmetries are a popular framework for addressing the flavour puzzle. Usually, the flavour symmetry group has been an ad hoc ... [more ▼]

Renormalizable SO(10) grand unified theory (GUT) models equipped with flavour symmetries are a popular framework for addressing the flavour puzzle. Usually, the flavour symmetry group has been an ad hoc choice, and no general arguments limiting this choice were known. In this paper, we establish the full list of flavour symmetry groups which may be enforced, without producing any further accidental symmetry, on the Yukawa-coupling matrices of an SO(10) GUT with arbitrary numbers of scalar multiplets in the ${\bf{10}}$, $\bar{{\bf{126}}}$, and ${\bf{120}}$ representations of SO(10). For each of the possible discrete non-Abelian symmetry groups, we present examples of minimal models which do not run into obvious contradiction with the phenomenological fermion masses and mixings. [less ▲]

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See detailLa gestion de la matière organique du sol, un enjeu important pour limiter la lixiviation du nitrate vers les eaux souterraines
Vandenberghe, Christophe ULg; Colinet, Gilles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 21

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive ... [more ▼]

Description of the subject. The nitrate concentration in half of the groundwater bodies of the Walloon Region (Belgium) has justified their classification as vulnerable zones under the Nitrates Directive (ND). This vulnerable area has a relatively high diversity of agro-soil environments. Thus, the nitrogen content of agricultural soils can vary locally by a factor 4. Objectives. This study aimed to establish whether the carbon content of a soil is a significant risk factor in nitrate leaching to groundwater. Method. The article is based on measurements of nitrate nitrogen residue (APL) and soil total organic carbon (TOC) at the beginning of the leaching period. The measurements were made in 2012 in 1,500 plots, during inspections organized by the Wallonia Public Service. This was as part of the application of the Program for the Sustainable Management of Nitrogen in Agriculture, the scheme for implementing the ND within the Walloon region. Results. Examination of the results showed both that the APL was positively correlated to the TOC and that plots with “noncompliant” APL results had a significantly higher average TOC than the other plots. Conclusions. Since APL is an environmental indicator of the risk of nitrate leaching, it appears that the TOC may constitute a risk of groundwater contamination by nitrate. It is therefore advisable to improve the inclusion of this parameter in advice regarding nitrogen fertilization and secondly, in the case of summer harvest, to better manage the sowing of catch crops. [less ▲]

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See detailX(5568) as a $su \bar d \bar b$ tetraquark in a simple quark model
Stancu, Floarea ULg

in Journal of Physics : G Nuclear & Particle Physics (2016), 43

The $S$-wave eigenstates of tetraquarks of type $s u \bar d \bar b$ with J$^{P}$ = 0$^{+}$, 1$^{+}$ and 2$^{+}$ are studied within a simple quark model with chromomagnetic interaction and effective quark ... [more ▼]

The $S$-wave eigenstates of tetraquarks of type $s u \bar d \bar b$ with J$^{P}$ = 0$^{+}$, 1$^{+}$ and 2$^{+}$ are studied within a simple quark model with chromomagnetic interaction and effective quark masses extracted from meson and baryon spectra. It is tempting to see if this spectrum can accommodate the new narrow structure X(5568), observed by the D\O~~Collaboration, but not confirmed by the LHCb Collaboration. If it exists, such a tetraquark is a system with four different flavors and its study can improve our understanding of multiquark systems. The presently calculated mass of X(5568) agrees quite well with the experimental value of he D\O~~Collaboration. Predictions are also made for the spectrum of the charmed partner $s u \bar d \bar c$. However we are aware of the difficulty of extracting effective quark masses, from mesons and baryons, to be used in multiquark systems. [less ▲]

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See detailNew role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity
Henry, Aurélie ULg; Nokin, Marie-Julie ULg; Leroi, Natacha ULg et al

in Oncotarget (2016)

Glioblastoma (GBM) represents the most aggressive and common solid human brain tumor. We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness ... [more ▼]

Glioblastoma (GBM) represents the most aggressive and common solid human brain tumor. We have recently demonstrated the importance of osteopontin (OPN) in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells. Consultation of publicly available TCGA database indicated that high OPN expression correlated with poor survival in GBM patients. In this study, we explored the role of OPN in GBM radioresistance using an OPN-depletion strategy in U87-MG, U87-MG vIII and U251-MG human GBM cell lines. Clonogenic experiments showed that OPN-depleted GBM cells were sensitized to irradiation. In comet assays, these cells displayed higher amounts of unrepaired DNA fragments post-irradiation when compared to control. We next evaluated the phosphorylation of key markers of DNA double-strand break repair pathway. Activating phosphorylation of H2AX, ATM and 53BP1 was signi cantly decreased in OPN-de cient cells. The addition of recombinant OPN prior to irradiation rescued phospho-H2AX foci formation thus establishing a new link between DNA repair and OPN expression in GBM cells. Finally, OPN knockdown improved mice survival and induced a signi cant reduction of heterotopic human GBM xenograft when combined with radiotherapy. This study reveals a new function of OPN in DNA damage repair process post-irradiation thus further con rming its major role in GBM aggressive disease. [less ▲]

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See detailAIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
Conteduca, Giuseppina ULg

in Oncotarget (2016)

AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in ... [more ▼]

AIRE is involved in susceptibility to melanoma perhaps regulating T cell immunity against melanoma antigens (MA). To address this issue, AIRE and MAGEB2 expressions were measured by real time PCR in medullary thymic epithelial cells (mTECs) from two strains of C57BL/6 mice bearing either T or C allelic variant of the rs1800522 AIRE SNP. Moreover, the extent of apoptosis induced by mTECs in MAGEB2-specific T cells and the susceptibility to in vivo melanoma B16F10 cell challenge were compared in the two mouse strains. The C allelic variant, protective in humans against melanoma, induced lower AIRE and MAGEB2 expression in C57BL/6 mouse mTECs than the T allele. Moreover, mTECs expressing the C allelic variant induced lower extent of apoptosis in MAGEB2-specific syngeneic T cells than mTECs bearing the T allelic variant (p < 0.05). Vaccination against MAGEB2 induced higher frequency of MAGEB2-specific CTL and exerted higher protective effect against melanoma development in mice bearing the CC AIRE genotype than in those bearing the TT one (p < 0.05). These findings show that allelic variants of one AIRE SNP may differentially shape the MA-specific T cell repertoire potentially influencing susceptibility to melanoma. [less ▲]

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See detailAbility of Tuta absoluta (Lepidoptera: Gelechiidae) to develop on alternative host plant species
Bawin, Thomas ULg; Dujeu, David; De Backer, Lara ULg et al

in Canadian Entomologist (2016), 148(4), 434-442

The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host ... [more ▼]

The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host range could help to understand and prevent the dispersion behavior of the insect in the environment. In this study, the ability of T. absoluta to develop on 12 cultivated or non-cultivated plants including Solanaceae, Chenopodiaceae, Convolvulaceae, Fabaceae and Malvaceae species under laboratory conditions was assessed. For each plant species, we monitored the development times of immature stages, survival, sex ratios and adult fecundity rates. All the 6 tested non-solanaceous plants, including Chenopodium, Convolvulus and Malva species, were not able to sustain (i.e. allow growth and development) T. absoluta larvae. Among Solanaceae, Solanum species were the most suitable host plants for the pest, but others could be opportunistically colonized with fewer incidences. T. absoluta appears to be strongly related to solanaceous plants which would predominantly support self-sustaining field populations. Preventing crop infestation by removing potential host plants in the immediate field vicinity and culture rotations with non-solanaceous crops is of primary importance. [less ▲]

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