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See detailTreacher Collins syndrome: a clinical and molecular study based on a large series of patients.
Vincent, Marie; Genevieve, David; Ostertag, Agnes et al

in Genetics in medicine : official journal of the American College of Medical Genetics (2016), 18(1), 49-56

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically ... [more ▼]

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. METHODS: We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. RESULTS: We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. CONCLUSION: Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.Genet Med 18 1, 49-56. [less ▲]

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See detailInterfacial activities of milk total proteose-peptone: contribution and miscibility of nonhydrophobic and hydrophobic fractions
Karamoko, Gaoussou; Renaville, Robert ULg; Blecker, Christophe ULg

in International Dairy Journal (2016), 62

Surface properties of a nonhydrophobic fraction of proteose-peptone (NHFPP) and a hydrophobic fraction of proteose-peptone (HFPP), obtained by hydrophobic-interaction chromatography, were investigated ... [more ▼]

Surface properties of a nonhydrophobic fraction of proteose-peptone (NHFPP) and a hydrophobic fraction of proteose-peptone (HFPP), obtained by hydrophobic-interaction chromatography, were investigated. Adsorption of NHFPP and HFPP on the surface activity of total proteose-peptone (TPP) followed a competitive mechanism, especially during the penetration phase and molecular rearrangements. Compression of mixed monolayers was used to study the miscibility of NHFPP and HFPP within TPP films. When NHFPP was mixed with HFPP, in a TPP film, both fractions were immiscible at the beginning of adsorption; they only became miscible when the polypeptide chains had moved from the surface to the aqueous phase, thus allowing a better organisation of proteins. The equation of excess free energy of compression was used to determine the interactions of NHFPP-HFPP within the TPP film through the mixed monolayer (thermodynamic properties); interactions between NHFPP and HFPP appeared less important than those that occurred between molecules within each fraction. [less ▲]

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See detailMetabolic profile of mixed culture acidogenic fermentation of lignocellulosic residues and the effect of upstream substrate fractionation by steam explosion
Perimenis, Anastasios; van Aarle, Ingrid; Nicolay, Thomas et al

in Biomass Conversion and Biorefinery (2016), 6

Lignocellulosic biomass residues have attracted attention for the sustainable production of molecules for material and energetic use through biochemical conversion. Their recalcitrant structure prevents a ... [more ▼]

Lignocellulosic biomass residues have attracted attention for the sustainable production of molecules for material and energetic use through biochemical conversion. Their recalcitrant structure prevents a broader use and asks for the development of sustainable techniques that can efficiently separate, recover and valorize the constituting components. In a cascading concept, residual streams of such processes can be further exploited in an attempt to valorize the largest possible fraction of the initial material. Three lignocellulosic substrates, namely dried sugar beet pulp, wheat bran and miscanthus straw, were upstream fractionated by steam explosion to extract the hemicellulose fraction. This study evaluated the valorization of the residual solid fraction through mixed acidogenic fermentation for the production of volatile fatty acids (VFA) as platform chemicals. Batch experiments have been conducted for the reference material (non-treated) and the solid fraction remaining after steam explosion, with and without the addition of an external mixed inoculum. Steam explosion residues contained less hemicellulose than the initial materials. The difference in the fermentation profile between steam explosion residues and non-treated substrates is dependent on the substrate. Maximum total VFA (tVFA) concentration was 18.8 gCOD/kgmixed_liquor, and maximum yield of chemical oxygen demand (COD) conversion into tVFAwas 33 % for the case of non-treated inoculated beet pulp. [less ▲]

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See detailThe role of metallothioneins, selenium and transfer to offspring in mercury detoxification in Franciscana dolphins (Pontoporia blainvillei)
Romero, M.B.; Pollizi, P.; Chiodi, L. et al

in Marine Pollution Bulletin (2016)

The concentrations of mercury (Hg), selenium (Se) and metallothioneins (MT) were evaluated in fetuses, calves, juveniles and adults of the endangered coastal Franciscana dolphin (Pontoporia blainvillei ... [more ▼]

The concentrations of mercury (Hg), selenium (Se) and metallothioneins (MT) were evaluated in fetuses, calves, juveniles and adults of the endangered coastal Franciscana dolphin (Pontoporia blainvillei) from Argentina. Mercury concentrations varied among analyzed tissues (liver, kidney, muscle and brain), with liver showing the higher concentrations in all specimens. An age-dependent accumulation was found in liver, kidney and brain. No significant relationship between Hg and MT concentrations was found for all tissues analyzed. Hepatic Hg molar concentrations were positively correlated with those of Se, indicating a great affinity between these two elements. Furthermore, dark granules of HgSe were observed in Kupffer cells in the liver by electron microscopy, suggesting the role of this macrophage in the detoxification of Hg. A transfer of Hg through placenta was proved. The presence of Hg in brain in all age classes did not show concentrations associated with neurotoxicity. [less ▲]

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See detailFrom "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour
Frère, Jean-Marie ULg; Sauvage, Eric ULg; Kerff, Frederic ULg

in Current drug targets (2016)

As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They ... [more ▼]

As early as 1940, Abraham and Chain described "an enzyme able to destroy penicillin". In the late 1940's, penicillin-resistant strains of Staphylococcus aureus were found to be a clinical problem. They produced a penicillinase that could hydrolyze the amide bond in the beta-lactam ring. Later, an enzyme mediated by an R-factor was isolated from Enterobacteriaceae. Methicillin and cephalosporins, both very poor substrates of the S. aureus enzyme, were found to be sensitive to this new enzyme. Third generation cephalosporins appeared to solve the problem, but further enzymes were selected that exhibited extended spectra and could for instance hydrolyze cefotaxime and/or ceftazidime. The discovery of carbapenems constituted a major advance for our antimicrobial arsenal: they inactivated most of the essential penicillin binding proteins effectively and escaped the activity of nearly all known beta-lactamases. However, the metallo-beta-lactamases, which had not been recognised as a major danger before 1990, were found to act as effective carbapenemases and started to spread in a worrying way. Moreover, carbapenem-hydrolyzing enzymes were found in each of the 3 classes of active-site serine beta-lactamases. [less ▲]

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See detailCore Outcome Measure Index for low back patients: do we miss anxiety and depression?
Cedraschi, C; Marty, M; Courvoisier, DS et al

in European Spine Journal (2016), 25

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See detailĐánh giá tiềm năng sử dụng phụ phẩm ngành rượu cồn để sản xuất thức ăn chăn nuôi tại Việt Nam
Tu Viet, Phu; Pham Kim, Dang; Nguyen Cong, Oanh ULg et al

in Journal of Science and Development (2016), 14(1), 36-45

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high ... [more ▼]

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high feed price due to the dependence on imported raw materials (estimated at 65-70%). The total value of imported raw materials for animal feed production in 2013 was estimated at $ 4.1 billion. Worldwide, by-products from alcohol industry has been studied and processed into main raw materials (DDG and DDGS) for animal feed production. Meanwhile in our country, these by-products are used in its raw form in livestock feeding or used for other purposes with low economic benefit. The objective of this study was to evaluate the potential uses of the by-products from alcohol industry to produce animal feed and increase the added value for these products. The main methods used in this study were Value Chain Analysis (VCA) and SWOT analysis. Results of the study showed the different value chains of the alcohol industry as well as opportunities for the use of by-products for the production of animal feed. The results also indicate the difficulties and challenges of these application. [less ▲]

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See detailDisplacement of an Electrically Charged Drop on a Vibrating Bath
Brandenbourger, Martin ULg; Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in Physical Review Letters (2016), 116

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See detailApoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.
Vidlickova, Ivana; Dequiedt, Franck ULg; Jelenska, Lenka et al

in BMC Cancer (2016), 16(1), 239

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion ... [more ▼]

BACKGROUND: Carbonic anhydrase IX (CA IX) is a tumor-associated, highly active, transmembrane carbonic anhydrase isoform regulated by hypoxia and implicated in pH control and adhesion-migration-invasion. CA IX ectodomain (ECD) is shed from the tumor cell surface to serum/plasma of patients, where it can signify cancer prognosis. We previously showed that the CA IX ECD release is mediated by disintegrin and metalloproteinase ADAM17. Here we investigated the CA IX ECD shedding in tumor cells undergoing apoptosis in response to cytotoxic drugs, including cycloheximide and doxorubicin. METHODS: Presence of cell surface CA IX was correlated to the extent of apoptosis by flow cytometry in cell lines with natural or ectopic CA IX expression. CA IX ECD level was assessed by ELISA using CA IX-specific monoclonal antibodies. Effect of recombinant CA IX ECD on the activation of molecular pathways was evaluated using the cell-based dual-luciferase reporter assay. RESULTS: We found a significantly lower occurrence of apoptosis in the CA IX-positive cell subpopulation than in the CA IX-negative one. We also demonstrated that the cell-surface CA IX level dropped during the death progress due to an increased ECD shedding, which required a functional ADAM17. Inhibitors of metalloproteinases reduced CA IX ECD shedding, but not apoptosis. The CA IX ECD release induced by cytotoxic drugs was connected to elevated expression of CA IX in the surviving fraction of cells. Moreover, an externally added recombinant CA IX ECD activated a pathway driven by the Nanog transcription factor implicated in epithelial-mesenchymal transition and stemness. CONCLUSIONS: These findings imply that the increased level of the circulating CA IX ECD might be useful as an indicator of an effective antitumor chemotherapy. Conversely, elevated CA IX ECD might generate unwanted effects through autocrine/paracrine signaling potentially contributing to resistance and tumor progression. [less ▲]

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See detail. Mass sensor utilising the mode-localisation effect in an electrostatically-coupled MEMS resonator pair fabricated using an SOI process
Wood, Graham; Chun, Zhao; Pu, Suan et al

in Microelectronic Engineering (2016), 159

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode ... [more ▼]

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode-localisation effect. It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode frequency, in response to a mass change, is five orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device. The device has been fabricated using a silicon-on-insulator (SOI) based process, which allows for high-yield and stiction-free fabrication. In addition, the design of the resonators has been created to have a larger surface area than previously reported designs, in order to facilitate future biological functionalisation. The mass sensitivity has been compared to current state-of-the-art mode-localised mass sensors and a 5.4 times increase in the amplitude ratio response to a given mass change has been demonstrated for the device in this work. [less ▲]

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See detailComparison of 4 point-of-care blood gas analyzers for arterial blood gas analysis in healthy dogs and dogs with cardiopulmonary disease
Roels, Elodie ULg; Gommeren, Kris ULg; Farnir, Frédéric ULg et al

in Journal of Veterinary Emergency and Critical Care (2016), 00(0), 1-8

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See detailHigh-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey.
Assfalg, Volker; Huser, Norbert; van Meel, Marieke et al

in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2016)

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement ... [more ▼]

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on the outcomes of HU transplantation are sparse and the benefit is controversial. METHODS: We systematically analysed data from 898 ET HU kidney transplant recipients from 61 transplant centres between 1996 and 2010 and investigated the 5-year patient and graft outcomes and differences between relevant subgroups. RESULTS: Kidney recipients with an HU status were younger (median 43 versus 55 years) and spent less time on the waiting list compared with non-HU recipients (34 versus 54 months). They received grafts with significantly more mismatches (mean 3.79 versus 2.42; P < 0.001) and the percentage of retransplantations was remarkably higher (37.5 versus 16.7%). Patient survival (P = 0.0053) and death with a functioning graft (DwFG; P < 0.0001) after HU transplantation were significantly worse than in non-HU recipients, whereas graft outcome was comparable (P = 0.094). Analysis according to the different HU indications revealed that recipients listed HU because of an imminent lack of access for dialysis had a significantly worse patient survival (P = 0.0053) and DwFG (P = 0.0462) compared with recipients with psychological problems and suicidality because of dialysis. In addition, retransplantation had a negative impact on patient and graft outcome. CONCLUSIONS: Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis. [less ▲]

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See detailSimultaneous multi-scale and multi-instrument observations of Saturn's aurorae during the 2013 observing campaign
Melin, H.; Badman, S.; Stallard, T. et al

in Icarus (2016)

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See detailToward “Concessions 2.0”: articulating inclusive and exclusive management in production forests in Central Africa
Karsenty, Alain; Vermeulen, Cédric ULg

in International Forestry Review (2016), 18(S1), 13

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes ... [more ▼]

Industrial forest concessions cover about 45 million hectares in Central Africa. This paper discusses the weaknesses of the current concession model and initiatives for helping it evolve; it then proposes a new type of concession, entitled ‘Concessions 2.0’, adapted to the future challenges presented by the overlapping among the rights and modes of the harvesting of multiple resources. This proposed model is based on four features: (i) mapping and recognition of the customary territories within and around the industrial concession, (ii) timber revenue sharing indexed on the extension of the customary territories and contractual management agreements within the communities, (iii) allowance of commercial exploitation of non-timber resources by entitled claimers under the supervision and/or in association with the concessionaire, and (iv) inclusive governance for the management of overlapping rights over the concession area. [less ▲]

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See detailTargeted control of the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), and the benefits of good control of this pest to winter wheat yield
Censier, Florence ULg; Chavalle, Sandrine ULg; San Martin y Gomez, Gilles et al

in Pest Management Science (2016)

BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe ... [more ▼]

BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe damage in cereals. In 2012 and 2013, field trials were conducted in heavily infested fields to assess its impact on winter wheat crops and to determine efficient ways of dealing with severe infestations. RESULTS: Crop exposure to H. marginata varied with the different protection methods tried. These methods included one to four successive applications of lambda-cyhalothrin. Yield losses were significant, reaching 6% in 2012 and as high as 15% in 2013, and these losses were linearly related to the number of galls on stems. CONCLUSION: The trials showed that insecticide applications needed to be synchronized with H. marginata flight peaks and to target the egg hatching period. They also revealed that insecticides applied to coincide with the first flight could, in humid conditions, also reach the larvae close to the soil surface, prior to their pupation. [less ▲]

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See detailTemperature and moisture storage in crop-based materials: Modelling a straw bale wall subject to a thermal shock
Dubois, Samuel ULg; Evrard, Arnaud ULg; Blecker, Christophe ULg et al

in Jounal of Building Physics (2016)

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any ... [more ▼]

Modelling the hygrothermal behaviour of crop-based insulation products is essential to assess their impact on the energy performance of the building, predict indoor climate conditions, and prevent any risk of unexpected degradation. Traditionally, transient numerical models that predict internal conditions of construction materials consider that the variation of moisture storage with temperature is negligible although the sorp- tion behaviour is known to be temperature dependent. This paper investigates this par- ticular effect for crop-based materials and uses a refinement of standard mathematical representations. For this purpose, the effects of a thermal shock on the evolution of hygrothermal conditions inside a straw-bale wall are studied with several versions of a flexible research model. The latter is capable of incorporating the temperature depen- dency of the sorption curve with both a physically-based and an empirical description. A large climate chamber is used to gather experimental data and is able to host a full- size straw bale prefabricated panel. Internal conditions of straw bales are obtained with proper sensors bars. Results show that when large temperature gradients occur in a crop-based material, a model that considers temperature effect on moisture storage enhances greatly the prediction of internal conditions. [less ▲]

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See detailMagneto-optical trapping of iron atoms
Crauwels, Justine ULg; Huet, Nicolas ULg; Krins, Stéphanie ULg et al

in Belgian Physical Society Magazine (2016), 1

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See detailInteractions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg; Lins, Laurence ULg et al

in Biochimie (2016), In Press

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became ... [more ▼]

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems. [less ▲]

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See detailSurfactant-assisted ultrasonic spray pyrolysis of hematite mesoporous thin films
Henrist, Catherine ULg; Toussaint, Caroline ULg; De Vroede, Jordan et al

in Microporous and Mesoporous Materials (2016), 221

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal ... [more ▼]

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal goethiteto-hematite phase transition. In a previous work, it has been reported that with very careful calcination steps, it is possible to prepare mesoporous hematite films with the spin-coating technique. However, with less conventional techniques such as surfactant-assisted ultrasonic spray pyrolysis, the deposition usually leads to non-porous oxide films or to films with interstitial porosity. In this work, we demonstrate for the first time the proof-of-concept of block-copolymer templating of hematite thin films by the ultrasonic spray pyrolysis technique. Despite the fast thermal decomposition during spray deposition, a regular, monodisperse packing of spherical pores is observed after deposition on pre-heated substrates (250 C) and after a careful post-annealing step at 470 C. Moreover, with the use of a silica scaffold, we successfully preserved porosity up to a temperature as high as 800 C. These films are highly crystalline and they are composed by randomly oriented nanocrystallites with sizes as small as 25 nm. Furthermore, we show that the crystallization evolution with temperature is influenced by the presence of the templating agent and also by the preparation technique. [less ▲]

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See detailComparative virucidal efficacy of seven disinfectants against murine norovirus and feline calicivirus, surrogates of human norovirus
Zonta, William ULg; Mauroy, Axel ULg; Farnir, Frédéric ULg et al

in Food and Environmental Virology (2016)

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge ... [more ▼]

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge of an efficient disinfection for both hands and food contact surfaces is helpful for the food sector and provides precious information for public health. The aim of this study was to evaluate the effect of seven disinfectants belonging to different groups of biocides (alcohol, halogen, oxidizing agents, quaternary ammonium compounds, aldehyde and biguanide) on infectious viral titre and on genomic copy number. Due to the absence of a cell culture system for HuNoV, two HuNoV surrogates such as murine norovirus (MNV) and feline calicivirus (FCV), were used and the tests were performed in suspension, on gloves and on stainless steel discs. When, as criteria of efficacy, a log reduction > 3 of the infectious viral titre on both surrogates and in the three tests is used, the most efficacious disinfectants in this study appear to be biocidal products B, C and D, representing the halogens, the oxidizing agents group and a mix of QAC, alcohol and aldehyde, respectively. In addition, these three disinfectants also elicited a significant effect on genomic copy number for both surrogate viruses and in all three tests. The results of this study demonstrate that a halogen compound, oxidizing agents and a mix of QAC, alcohol and aldehyde are advisable for HuNoV disinfection of either potentially contaminated surfaces or materials in contact with foodstuffs. [less ▲]

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See detailTree light capture and spatial variability of understory light increase with species mixing and tree size heterogeneity
Ligot, Gauthier ULg; Ameztegui, Aitor; Courbaud, Benoît et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2016)

Mixed and multi-layered forest ecosystems are sometimes more productive than monospecific and single-layered ones. It has been suggested that trees of different species and sizes occupy complementary ... [more ▼]

Mixed and multi-layered forest ecosystems are sometimes more productive than monospecific and single-layered ones. It has been suggested that trees of different species and sizes occupy complementary positions in space which would act as a mechanism to increase canopy light interception and wood production. However, greater canopy light interception reduces the average amount and variability of transmitted radiation offering fewer opportunities for all species to regenerate and to maintain forest heterogeneity in the long-run. We investigated whether increasing overstory heterogeneity indeed results in greater canopy light interception and lower variability in transmittance. We modeled the three-dimensional structure of forest stands with 3 typical forest structures, 10 mixtures of four tree species, and 3 different basal areas. We used the forest light interception model SAMSARALIGHT and performed three-way analyses of covariance to analyze the effects of the three varied components of forest heterogeneity. We found no evidence that increasing heterogeneity increases canopy light interception. In contrast, homogeneous stands intercept more light than heterogeneous stands. Variability in transmittance increased in some cases with compositional heterogeneity and, to a lesser extent, with tree size inequalities. The advantage of heterogeneous forests is in opportunities for natural regeneration rather than in opportunities to enhance canopy light interception. [less ▲]

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See detailCOMPARISON OF ULTRASOUND-GUIDED VS. STANDARD LANDMARK TECHNIQUES FOR TRAINING NOVICE OPERATORS IN PLACING NEEDLES INTO THE LUMBAR SUBARACHNOID SPACE OF CANINE CADAVERS
Etienne, Anne-Laure ULg; Delguste, Catherine ULg; Busoni, Valeria ULg

in Veterinary Radiology & Ultrasound (2016)

The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this ... [more ▼]

The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this technique can be challenging for novice operators. The aim of the current observational, prospective, ex vivo, feasibility study was to compare ultrasound-guided vs. standard anatomic landmark approaches for novices performing needle placement into the lumbar subarachnoid space using dog cadavers. Eight experienced operators validated the canine cadaver model as usable for training landmark and ultrasound-guided needle placement into the lumbar subarachnoid space based on realistic anatomy and tissue consistency. With informed consent, 67 final year veterinary students were prospectively enrolled in the study. Students had no prior experience in needle placement into the lumbar subarachnoid space or use of ultrasound. Each student received a short theoretical training about each technique before the trial and then attempted blind landmark-guided and ultrasound-guided techniques on randomized canine cadavers. After having performed both procedures, the operators completed a self-evaluation questionnaire about their performance and self-confidence. Total success rates for students were 48% and 77% for the landmark- and ultrasound-guided techniques, respectively. Ultrasound guidance significantly increased total success rate when compared to the landmark-guided technique and significantly reduced the number of attempts. With ultrasound guidance self-confidence was improved, without bringing any significant change in duration of the needle placement procedure. Findings indicated that use of ultrasound guidance and cadavers are feasible methods for training novice operators in needle placement into the canine lumbar subarachnoid space. [less ▲]

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See detailRisk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.
Garigliany, Mutien-Marie ULg; Jolly, Sandra ULg; Dive, M. et al

in The Veterinary record (2016), 178(2), 45

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in ... [more ▼]

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in 302 stray cats captured during a trap-neuter-release programme in a mixed urban-rural area from Belgium, from 2010 to 2012. The impact of selective removal of FIV-positive cats on the apparent prevalence in the remaining population over this three-year period was also assessed. The seroprevalences over three years were 18.8 per cent for FIV and 0.7 per cent for FeLV. For FIV, the seroprevalence decreased significantly from the first year of the programme (2010; 30.5 per cent) to the last (2012; 13.1 per cent). Sex (male) and age (adult and old cats) were risk factors, while the year of sampling (years 2011 and 2012) was a protective factor. Age, sex and location were the most relevant predictors of FIV status. The data presented in this study revealed a very high FIV seroprevalence in Belgian stray cats, while FeLV was almost absent. The selective removal of positive cats had a drastic effect on the FIV seroprevalence in the remaining cat population. [less ▲]

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See detailMetabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.
Frederich, Michel ULg; Pirotte, Bernard ULg; Fillet, Marianne ULg et al

in Journal of Medicinal Chemistry (2016)

"Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at ... [more ▼]

"Omics" sciences have been developed to provide a holistic point of view of biology and to better understand the complexity of an organism as a whole. These systems biology approaches can be examined at different levels, starting from the most fundamental, i.e., the genome, and finishing with the most functional, i.e., the metabolome. Similar to how genomics is applied to the exploration of DNA, metabolomics is the qualitative and quantitative study of metabolites. This emerging field is clearly linked to genomics, transcriptomics, and proteomics. In addition, metabolomics provides a unique and direct vision of the functional outcome of an organism's activities that are required for it to survive, grow, and respond to internal and external stimuli or stress, e.g., pathologies and drugs. The links between metabolic changes, patient phenotype, physiological and/or pathological status, and treatment are now well established and have opened a new area for the application of metabolomics in the drug discovery process and in personalized medicine. [less ▲]

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See detailSmall-angle scattering and scale-dependent heterogeneity
Gommes, Cédric ULg

in Journal of Applied Crystallography (2016), 49

Although small-angle scattering is often discussed qualitatively in terms of material heterogeneity, when it comes to quantitative data analysis this notion becomes somehow hidden behind the concept of ... [more ▼]

Although small-angle scattering is often discussed qualitatively in terms of material heterogeneity, when it comes to quantitative data analysis this notion becomes somehow hidden behind the concept of correlation function. In the present contribution, a quantitative measure of heterogeneity is defined, it is shown how it can be calculated from scattering data, and its structural significance for the purpose of material characterization is discussed. Conceptually, the procedure consists of using a finite probe volume to define a local average density at any point of the material; the heterogeneity is then quantitatively defined as the fluctuations of the local average density when the probe volume is moved systematically through the sample. Experimentally, it is shown that the so-defined heterogeneity can be estimated by projecting the small-angle scattering intensity onto the form factor of the chosen probe volume. Choosing probe volumes of various sizes and shapes enables one to comprehensively characterize the heterogeneity of a material over all its relevant length scales. General results are derived for asymptotically small and large probes in relation to the material surface area and integral range. It is also shown that the correlation function is equivalent to a heterogeneity calculated with a probe volume consisting of two points only. The interest of scale-dependent heterogeneity for practical data analysis is illustrated with experimental small-angle X-ray scattering patterns measured on a micro- and mesoporous material, on a gel, and on a semi-crystalline polyethylene sample. Using different types of probes to analyse a given scattering pattern enables one to focus on different structural characteristics of the material, which is particularly useful in the case of hierarchical structures. [less ▲]

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See detailKisspeptin Expression in the Human Infundibular Nucleus in Relation to Sex, Gender Identity, and Sexual Orientation.
Taziaux, Mélanie ULg; Staphorsius, Annemieke S.; Ghatei, Mohammad A. et al

in Journal of Clinical Endocrinology and Metabolism (2016), 101(6), 2380-9

CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex ... [more ▼]

CONTEXT: Since the discovery of its central role in reproduction, our functional neuroanatomical knowledge of the hypothalamic kisspeptin system is predominantly based on animal studies. Although sex differences in kisspeptin expression have been shown in humans in adulthood, the developmental origin of this sex difference is unknown. OBJECTIVES: Our objectives were to determine the following: 1) when during development the sex difference in kisspeptin expression in the infundibular nucleus would emerge and 2) whether this sex difference is related to sexual orientation or transsexuality. DESIGN AND SETTING: Postmortem hypothalamic tissues were collected by The Netherlands Brain Bank, and sections were stained for kisspeptin by immunohistochemistry. PATIENTS: Hypothalami of 43 control subjects were categorized into three periods: infant/prepubertal (six girls, seven boys), adult (11 women, seven men), and elderly (six aged women, six aged men). Eight male-to-female (MTF) transsexuals, three HIV(+) heterosexual men, and five HIV(+) homosexual men were also analyzed. MAIN OUTCOME MEASURE: We estimated the total number of kisspeptin-immunoreactive neurons within the infundibular nucleus. RESULTS: Quantitative analysis confirmed that the human infundibular kisspeptin system exhibits a female-dominant sex difference. The number of kisspeptin neurons is significantly greater in the infant/prepubertal and elderly periods compared with the adult period. Finally, in MTF transsexuals, but not homosexual men, a female-typical kisspeptin expression was observed. CONCLUSIONS: These findings suggest that infundibular kisspeptin neurons are sensitive to circulating sex steroid hormones throughout life and that the sex reversal observed in MTF transsexuals might reflect, at least partially, an atypical brain sexual differentiation. [less ▲]

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See detailLa gouvernance et le financement de l’enseignement supérieur: une approche microéconomique
Jacqmin, Julien ULg

in Reflets et Perspectives de la Vie Economique (2016), 2

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de ... [more ▼]

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de financement et de gouvernance auxquels font face les établissements de ce secteur. Premièrement, le lien entre le financement public du secteur et l’émergence de certains types d’institution est étudié. Ensuite, un modèle mettant en exergue le rôle de la composition du conseil d’administration est présenté. La dernière partie porte sur les conséquences d’une dérégulation des frais d’inscription. En conclusion, quelques aspects de l’enseignement supérieur en Fédération Wallonie-Bruxelles sont présentés à la lumière des différents points abordés. [less ▲]

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See detailAMPK is involved in the differential neonatal performance of chicks hatching at different time
Wang, Yuan ULg; Buyse, J.; Song, Z. et al

in General and Comparative Endocrinology (2016), 228

We have recently reported that the hatching time may be in relation to the distinct neonatal performance of female chicks. The present study was aimed to investigate the potential involvement of AMPK, an ... [more ▼]

We have recently reported that the hatching time may be in relation to the distinct neonatal performance of female chicks. The present study was aimed to investigate the potential involvement of AMPK, an energy sensor which plays a pivotal role in energy homeostasis, in the distinct performance of the spread of hatching time model. As a result, hypothalamic AMPKα1 isoform gene expression was significantly higher in the late hatcher as compared to that of their early counterparts, whereas the total and phosphorylated levels of AMPKα subunit did not differ between the three hatchers. The hypothalamic orexigenic NPY and AgRP mRNA levels were higher in the late hatchers as compared to the early, and that of the middle hatchers was at an intermediate level. However, the anorexigenic POMC and CRH was also higher expressed in the late hatchers as compared to the early hatchers. In the liver, AMPKα2 mRNA level and the phosphorylation ratio of AMPKα was significantly lower in the late hatchers, as compared to their early counterparts. The hepatic phosphorylated GS levels of the late and middle hatchers were lower than that of their early counterparts. The expression of hepatic FTO gene of the late hatchers was significantly higher than that of their early and middle counterparts. Taken together, AMPK may play a significant role in the different neonatal performance of the spread of hatching time model. The central and peripheral AMPK in late hatchers exhibited a pattern of higher energy intake and lower energy expenditure, which resulted in a faster post-hatch growth. © 2016 Elsevier Inc. [less ▲]

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See detailForced Convective Drying of Wastewater Sludge with Presentation of Exergy Analysis of the Dryer
Bennamoun, Lyes; Fraikin, Laurent ULg; Li, Jie et al

in Chemical Engineering Communications (2016), 203

The main objective is studying the fundamental aspect, by the mean of the drying kinetics, the application of forced convective drying of wastewater sludge with determination of the optimum drying ... [more ▼]

The main objective is studying the fundamental aspect, by the mean of the drying kinetics, the application of forced convective drying of wastewater sludge with determination of the optimum drying conditions. The drying system is composed of two units; small samples of 2.5 g are dried in the first unit and bed of sludge weighting 250 g is dried the second unit. The experiments are performed under air temperatures varying between 80°C and 200°C. The range of the air velocity and its humidity is 1- 2 m/s and 0.005- 0.05 kgwater/kgdry air, respectively. The experiments are performed for two different sludges; activated sludge (AS) and thermalized and digested sludge (TDS). Usually, three main drying phases are observed during drying of bed of sludge. These phases are reduced to only two for small samples. Determination of the influent parameters shows that temperature of the drying air and sludge origin can profoundly influence the drying kinetic of the sludge. The exergy analysis of the two units of the drying system allows selecting 140 °C, 2 m/s, 0.05 kgwater/kgdry air as optimum drying condition with an exergy efficiency reaching 90\%. [less ▲]

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See detailL’enfant, l’institutrice et le tableau interactif : Corps relationnel et évolution numérique
Jadin, Aurore ULg; Englebert, Jérôme ULg

in Cahiers de Psychologie Clinique (2016), 46

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical ... [more ▼]

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical case, a reflection on the technological change of classes, particularly through the use of the interactive whiteboard, and the psychological and relational consequences of this revolution, for each of the protagonists. A consequence of this use of the digital device is that the body can appear less necessary and therefore be abandoned in favor of a poorly invested technicality. Our analysis values the development of a necessary compromise between digital and body. It proposes to find ways of arranging so that teacher's body is still a fundamental dimension of the educational process. [less ▲]

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.
Maheu, E.; Rannou, F.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]

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See detailDu meurtre commis pour faciliter le vol : considérations critiques
Jacques, Elodie ULg

in Revue de Droit Pénal et de Criminologie (2016)

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See detailFood peptides: purification, identification and role in the metabolism.
Arroume, N.; Froidevaux, R.; Kapel, R. et al

in Current opinion in Food science (2016), 7

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See detailN-Acetylcysteine: An Old Drug With Variable Anti-Influenza Properties
Casanova, Tomas; Garigliany, Mutien-Marie ULg

in Journal of Controversies in Biomedical Research (2016)

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See detailWill delayed release metformin provide better management of diabetes type 2?
Scheen, André ULg

in Expert opinion on pharmacotherapy (2016), 17(5), 627-30

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See detailBetween Street Vendors, Singing Slaves, and Envy
Vanesse, Sylvain ULg

in Chronika (2016), 6

When the well-known “House of the Ephebe” was excavated in Pompeii, a statuary group composed of four bronze figurines was found. Those small statues are now known as “Placentarii”, namely “pastry cooks.” ... [more ▼]

When the well-known “House of the Ephebe” was excavated in Pompeii, a statuary group composed of four bronze figurines was found. Those small statues are now known as “Placentarii”, namely “pastry cooks.” They were given this name because they were thought selling their products placed on a plate, shouting to attract the clients. This interpretation explains the particular hand gesture of those men, touching their throat. This theory seems very conceivable and is generally accepted by a large scientific majority. However, some iconographic elements don’t fit with this hypothesis. Indeed, how do we explain the nakedness of those four men, their thinness, their weird facial features and their disproportionate phalluses? Other figurines – terracotta, bronzes, amulets, mosaics – depicted with the same specific features were found among the archaeological material from the Mediterranean basin. There is –nearly– no question that those objects are representations of the Envy personified, also known as Phthonos, or of an envious person (phthoneros). Would it be possible to see in those four bronzes not –only– pastry cooks, but an embodiment of Envy, filled with apotropaic value? A fresh perspective –literary and archaeological– will help and issue a clarification about this new theory. [less ▲]

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See detailQuantitative assessment of mouse mammary gland morphology using automated digital image processing and TEB detection.
Blacher, Silvia ULg; Gérard, Céline ULg; Gallez, Anne ULg et al

in Endocrinology (2016)

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative ... [more ▼]

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative pathological implications. In this work, we propose a methodology relying on fully automated digital image analysis methods including image processing and quantification of the whole ductal tree and of the terminal end buds (TEB) as well. It allows to accurately and objectively measure both growth parameters and fine morphological glandular structures. Mammary gland elongation was characterized by two parameters: the length and the epithelial area of the ductal tree. Ductal tree fine structures were characterized by: 1) branch end-point density, 2) branching density and 3) branch length distribution. The proposed methodology was compared to quantification methods classically used in the literature. This procedure can be transposed to several software and thus largely used by scientists studying rodent mammary gland morphology. [less ▲]

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See detailThe transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.
Rambout, Xavier ULg; Detiffe, Cecile; Bruyr, Jonathan et al

in Nature Structural & Molecular Biology (2016)

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical ... [more ▼]

Control of mRNA levels, a fundamental aspect in the regulation of gene expression, is achieved through a balance between mRNA synthesis and decay. E26-related gene (Erg) proteins are canonical transcription factors whose previously described functions are confined to the control of mRNA synthesis. Here, we report that ERG also regulates gene expression by affecting mRNA stability and identify the molecular mechanisms underlying this function in human cells. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. Transcriptome-wide mRNA stability analysis revealed that ERG controls the degradation of a subset of mRNAs highly connected to Aurora signaling, whose decay during S phase is necessary for mitotic progression. Our data indicate that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, integrating mRNA synthesis and degradation. [less ▲]

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See detail« La Théorie critique n’a aucun rapport avec la société. » Kluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Tijdschrift voor Filosofie (2016), 78

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to ... [more ▼]

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to create a « reformed circus » which aims at reintroducing some sensuality in the spectator’s experience. Taking this project as well as its central figure, the apparently passive elephant, as a metaphorical starting point, this article reconstitutes a virtual dialogue between the filmmaker and his friend and former master Theodor W. Adorno around the issue of communicability and effectiveness of Critical Theory. Crossing several text fragments by the philosopher (Dialectic of Enlightenment, Resignation and Education After Auschwitz a.o.) with film excerpts, short stories and interviews by Kluge, this dialogue made of real exchanges, as well as direct and indirect quotes of Adorno in Kluge’s films – considered here to be belated joint projects –, finally tries to give an answer to following crucial question: how can Adorno’s critical reflection remain politically, that is socially effective. [less ▲]

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See detailInvestigation of the genotoxicity of substances migrating from polycarbonate replacement baby bottles to identify chemicals of high concern.
Mertens; Simon, Coraline ULg; Van Bossuyt et al

in Food & Chemical Toxicology (2016), 89

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See detailPrevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.
Muysoms, Filip E.; DETRY, Olivier ULg; Vierendeels, Tijl et al

in Annals of surgery (2016), 263(4), 638-645

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]

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See detailDetermination of total phenolic compounds content and antioxidant activity in cherry species and cultivars
Pissard, Audrey; Lateur, Marc; Baeten, V et al

in Journal of Berry Research (2016)

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound ... [more ▼]

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound (TPC) content and the antioxidant capacity (AC) of a large range of cultivars using the same methodology in one laboratory, and (ii) determine the possible relationship between agronomic characteristics and AC. METHODS: A total of 245 samples including sweet, sour and hybrid cultivars from our collections were harvested at their optimum maturity and characterized according to their TPC, DPPH and ORAC values. RESULTS: The TPC content and DPPH and ORAC values varied greatly among the cherries, with the sour cultivars presenting higher levels than the sweet ones. The PCA plot showed a slight grouping by species and confirmed the high TPC content level in sour cultivars. The bi-colored cultivars had lower TPC and antioxidant capacity (AC) values than dark-colored ones, indicating that coloration could give an indication of the AC of fruits. No significant relationship between the agronomic and chemical properties was highlighted. CONCLUSIONS: Cherry fruits, especially from sour cultivars, represent an important source of bioactive compounds and could attract new interest as a ‘functional food’. [less ▲]

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (1),

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See detailVirtual Issue celebrating the 100th volume of the Journal of Animal Physiology and Animal Nutrition
Fascetti, A. J.; Everaert, Nadia ULg

in Journal of Animal Physiology and Animal Nutrition (2016), 100(1), 1-2

[No abstract available]

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See detailEnvironmental and economic benefits of variable rate nitrogen fertilization in a nitrate vulnerable zone
Basso, Bruno; Dumont, Benjamin ULg; Cammarano, Davide et al

in Science of the Total Environment (2016), 545/546

Agronomic input and management practices have traditionally been applied uniformly on agricultural fields despite the presence of spatial variability of soil properties and landscape position. When spatial ... [more ▼]

Agronomic input and management practices have traditionally been applied uniformly on agricultural fields despite the presence of spatial variability of soil properties and landscape position. When spatial variability is ignored, uniform agronomic management can be both economically and environmentally inefficient. The objectives of this study were to: i) identify optimal N fertilizer rates using an integrated spatio-temporal analysis of yield and site-specific N rate response; ii) test the sensitivity of site specific N management to nitrate leaching in response to different N rates; and iii) demonstrate the environmental benefits of variable rate N fertilizer in a Nitrate Vulnerable Zone. This study was carried out on a 13.6 ha field near the Venice Lagoon, northeast Italy over four years (2005–2008). We utilized a validated crop simulation model to evaluate crop response to different N rates at specific zones in the field based on localized soil and landscape properties under rainfed conditions. The simulated rates were: 50 kg N ha -1 applied at sowing for the entire study area and increasing fractions, ranging from 150 to 350 kg N ha -1 applied at V6 stage. Based on the analysis of yield maps from previous harvests and soil electrical resistivity data, three management zones were defined. Two N rates were applied in each of these zones, one suggested by our simulation analysis and the other with uniform N fertilization as normally applied by the producer. N leaching was lower and net revenue was higher in the zones where variable rates of N were applied when compared to uniform N fertilization. This demonstrates the efficacy of using crop models to determine variable rates of N fertilization within a field and the application of variable rate N fertilizer to achieve higher profit and reduce nitrate leaching. [less ▲]

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See detailExperimental Neospora caninum infection modifies trophoblast cell populations and plasma pregnancy-associated glycoprotein 1 and 2 dynamics in pregnant dairy heifers.
Mur-Novales, R.; Serrano-Perez, B.; Garcia-Ispierto, I. et al

in Veterinary parasitology (2016), 216

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast ... [more ▼]

Neospora caninum is an obligate intracellular protozoan that causes abortion in cattle worldwide. Plasma concentrations of pregnancy-associated glycoprotein 1 (PAG-1), produced by binucleate trophoblast cells, are used for pregnancy diagnosis and as a marker of foetal-placental well-being, while PAG-2, produced by both mono- and binucleate trophoblast cells, may serve as an indicator of abortion risk. In prior work, natural N. caninum infection was found to modify plasma PAG-1 and PAG-2 patterns. The present study examines PAG-1 and PAG-2 dynamics and trophoblast cell populations following experimental infection with N. caninum. The study population was comprised of 17 N. caninum seronegative Holstein-Friesian heifers. On day 110 of gestation, 6 heifers were inoculated intravenously with 10(7) taquyzoites of N. canimum. Plasma samples for PAG-1 and PAG-2 determinations were collected on days 0, 7, 14, 21 and 42 post infection. During the study course, pregnancy was normally expressed in all controls while three infected heifers lost their foetuses. All heifers were euthanised on day 42 post infection and placentome samples from the 14 non-aborting heifers were collected to examine trophoblast cell populations. Plasma PAG-1 and PAG-2 concentrations in non-infected heifers increased until the day of euthanasia while non-aborting infected heifers showed a temporary fall in PAG-1 (P<0.004) and PAG-2 (P<0.002) concentrations from 7 to 14 days post infection (dpi). The two dams aborting at 14 and 21 dpi and a third dam with a mummified foetus upon euthanasia showed dramatic PAG-1 and PAG-2 reductions from 14 dpi to undetectable levels upon euthanasia. A stereological study of placentomes revealed significantly higher relative proportions of mono- (P=0.035) and binucleate (P=0.029) trophoblast cells at 42 dpi in non-infected heifers than infected non-aborting heifers. According to our findings, following experimental N. caninum infection on day 110 of gestation, non-aborting heifers showed a brief reversible drop in plasma PAG-1 and 2 concentrations two weeks later and reduced proportions of bi- and mono-nucleate trophoblast cells 42 days after infection. In aborting dams, dramatically reduced PAG levels were related to severe placental damage and a non-viable pregnancy. [less ▲]

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See detailFe3+/Iron Oxide/SiO2 Xerogel Catalysts for p-nitrophenol Degradation by Photo-Fenton Effects: Influence of Thermal Treatment on Catalysts Texture
Mahy, Julien ULg; Tasseroul, Ludivine ULg; Herlitscke, Marcus et al

in Materials Today: Proceedings (2016), 3(2), 464-469

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. Four thermal treatments were applied to catalysts: drying, drying-autoclaving, calcination and calcination-autoclaving. Textural characterizations show that the specific surface area is increased by calcination while materials microporosity completely collapse when using autoclaving. Based on Mössbauer spectroscopy and magnetometry measurements, only Fe3+ species were observed in xerogel catalysts. The photo-Fenton effect of these catalysts was evaluated on the degradation of p-nitrophenol in aqueous media. In the presence of H2O2, results show that this effect reachs 99% of degradation after 24 h. Mössbauer and catalytic tests are presented in another paper. [less ▲]

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See detailThe CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity
Jourdan, Samuel ULg; Francis, Isolde; Kim, Min et al

in Scientific Reports (2016)

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See detailDecitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group
Lübbert, Michael; Suciu, Stefan; Hagemeijer, Anne et al

in Annals of Hematology (2016), 95

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal ... [more ▼]

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal monosomies (MK2+) within a complex karyotype (Lübbert et al., Haematologica 97:393-401, 2012). We now analyzed 206 myelodysplastic syndrome (MDS) patients (88 % of 233 patients randomized in the EORTC/GMDSSG phase III trial 06011, 61 of them with RAEBt, i.e. AML by WHO) with cytogenetics informative for MK status.. Endpoints are the following: complete/partial (CR/PR) and overall response rate (ORR) and progression-free (PFS) and overall survival (OS). Cytogenetic subgroups are the following: 63 cytogenetically normal (CN) patients, 143 with cytogenetic abnormalities, 73 of them MKnegative (MK−), and 70 MK-positive (MK+). These MK+ patients could be divided into 17 with a single autosomal monosomy (MK1) and 53 with at least two monosomies (MK2+). ORR with DAC in CN patients: 36.1 %, in MK−patients: 16.7 %, in MK+ patients: 43.6 % (MK1: 44.4 %, MK2+ 43.3 %). PFS was prolonged by DAC compared to best supportive care (BSC) in the CN (hazard ratio (HR) 0.55, 99 % confidence interval (CI), 0.26; 1.15, p=0.03) and MK2+ (HR 0.50; 99%CI, 0.23; 1.06, p=0.016) but not in the MK−, MK+, and MK1 subgroups. OS was not improved by DAC in any subgroup. In conclusion, we demonstrate for the first time in a randomized phase III trial that high-risk MDS patients with complex karyotypes harboring two or more autosomal monosomies attain encouraging responses and have improved PFS with DAC treatment compared to BSC. [less ▲]

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See detailUn volvulus du sigmoïde: le rôle du radiologue
DEQUIEDT, C; MILICEVIC, Mladen ULg

in Revue Médicale de Liège (2016), 71(5), 252-255

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa ... [more ▼]

Le volvulus du sigmoïde est la troisième cause d'obstruction colique après le carcinome et la diverticulite (1) dans nos contrées et deviendra une cause encore plus importante dans le futur étant donné sa prévalence chez les personnes âgées et/ou institutionnalisées. De plus, c’est la première cause d’obstruction intestinale chez la femme enceinte. Étant donné sa clinique peu spécifique, le clinicien doit faire appel aux examens complémentaires et surtout radiographiques pour le diagnostic (2). Le rôle du radiologue est donc primordial dans le diagnostic et pour certains cas dans la thérapeutique du volvulus du sigmoïde. Ceci n’est pas anodin étant donné la morbi/mortalité importante de cette pathologie. Nous vous rapportons ici le cas typique d’un patient de 60 ans se présentant aux urgences pour des vomissements et le ballonnement depuis quelques jours. [less ▲]

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See detailCultural Practices Shaping Zoonotic Diseases Surveillance: The Case of Highly Pathogenic Avian Influenza and Thailand Native Chicken Farmers.
Delabouglise, Alexis; Antoine-Moussiaux, Nicolas ULg; Tatong, D. et al

in Transboundary and Emerging Diseases (2016)

Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive ... [more ▼]

Effectiveness of current passive zoonotic disease surveillance systems is limited by the under-reporting of disease outbreaks in the domestic animal population. Eval- uating the acceptability of passive surveillance and its economic, social and cul- tural determinants appears a critical step for improving it. A participatory rural appraisal was implemented in a rural subdistrict of Thailand. Focus group inter- views were used to identify sanitary risks perceived by native chicken farmers and describe the structure of their value chain. Qualitative individual interviews with a large diversity of actors enabled to identify perceived costs and benefits associ- ated with the reporting of HPAI suspicions to sanitary authorities. Besides, flows of information on HPAI suspected cases were assessed using network analysis, based on data collected through individual questionnaires. Results show that the presence of cockfighting activities in the area negatively affected the willingness of all chicken farmers and other actors to report suspected HPAI cases. The high financial and affective value of fighting cocks contradicted the HPAI control pol- icy based on mass culling. However, the importance of product quality in the native chicken meat value chain and the free veterinary services and products delivered by veterinary officers had a positive impact on suspected case reporting. Besides, cockfighting practitioners had a significantly higher centrality than other actors in the information network and they facilitated the spatial diffusion of information. Social ties built in cockfighting activities and the shared purpose of protecting valuable cocks were at the basis of the diffusion of information and the informal collective management of diseases. Building bridges with this informal network would greatly improve the effectiveness of passive surveillance. [less ▲]

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See detailStudying Self-Awareness in Children: Validation of the Questionnaire of Executive Functioning (QEF)
Geurten, Marie ULg; Catale, Corinne ULg; Geurten, Claire ULg et al

in Clinical Neuropsychologist (The) (2016)

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of ... [more ▼]

Objective: People with accurate representations of their own cognitive functioning (i.e., cognitive self-awareness) tend to use appropriate strategies to regulate their behavior. Due to the lack of appropriate instruments, few studies have examined the development of this ability among children. Method: This study tested the measurement properties of the self-rating and other-rating forms of the Questionnaire of Executive Functioning (QEF), designed to tap children’s knowledge of their executive functioning. Specifically, the construct, convergent, and discriminant validities were investigated and a self-other discrepancy score was computed to assess children’s executive self-awareness. Participants were 317 children aged 7 to 14 years old. Results: Confirmatory factor analyses carried out on the QEF confirmed the eight-factor structure of both versions. There were significant correlations between the QEF and the parent versions of the Behavior Rating Inventory of Executive Function, the Dysexecutive Questionnaire for Children, and the Childhood Executive Functioning Inventory. Both forms of the QEF were able to distinguish between children who had sustained a traumatic brain injury (TBI) and control participants. A statistical difference was observed between the TBI and control groups on this score, suggesting that TBI may trigger self-awareness impairments in children. Conclusion: The good psychometric properties of the two forms of the QEF were established. Furthermore, results of the analyses carried out on the different discrepancy scores seem to indicate that the QEF could help clinicians to detect patients with self-awareness deficits. [less ▲]

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See detailA Belgian Survey on Geriatric Assessment in Oncology Focusing on Large-Scale Implementation and Related Barriers and Facilitators.
Kenis, C.; Heeren, P.; Decoster, L. et al

in The journal of nutrition, health & aging (2016), 20(1), 60-70

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for ... [more ▼]

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for implementing GA in this setting. Design / setting / participants: The principal investigator of every participating hospital (n=22) was invited to complete a newly developed questionnaire with closed- and open-ended questions. The closed-ended questions surveyed how GA was implemented. The open-ended questions identified barriers and facilitators for the implementation of GA in daily oncology practice. Descriptive statistics and conventional content analysis were performed as appropriate. RESULTS: Qualifying criteria (e.g. disease status and cancer type) for GA varied substantially between hospitals. Thirteen hospitals (59.1%) succeeded to screen more than half of eligible patients. Most hospitals reported that GA data and follow-up data had been collected in almost all screened patients. Implementing geriatric recommendations and formulating new geriatric recommendations at the time of follow-up are important opportunities for improvement. The majority of identified barriers were organizational, with high workload, lack of time or financial/staffing problems as most cited. The most cited facilitators were all related to collaboration. CONCLUSION: Interventions to improve the implementation of GA in older patients with cancer need to address a wide range of factors, with organization and collaboration as key elements. All stakeholders, seeking to improve the implementation of GA in older patients with cancer, should consider and address the identified barriers and facilitators. [less ▲]

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See detailRugose corals across the Devonian-Carboniferous boundary in NW Turkey
Denayer, Julien ULg

in Acta Palaeontologica Polonica (2016), 61(1), 51-70

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See detailBreast cancer in a male to female transsexual patient with a BRCA2 mutation
CORMAN, Vinciane ULg; Potorac, Iulia ULg; Manto, Florence ULg et al

in Endocrine-Related Cancer (2016)

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See detailProcrastination, consideration of future consequences, and episodic future thinking
Rebetez, Marie My Lien; Barsics, Catherine ULg; Rochat, Lucien et al

in Consciousness & Cognition (2016), 42

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See detailFossil Biogeography: A new model to infer dispersal, extinction and sampling from paleontological data
Silvestro, Daniele; Zizka, Alexander; Bacon, Christine D. et al

in Philosophical Transactions : Biological Sciences (2016)

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See detailRecording and Reading Alchemy and Art-Technology in Medieval and Premodern German Recipe Collections
Neven, Sylvie ULg

in Nuncius. Journal of the Material and Visual History of Science (2016)

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See detailThe alarming increase in antibiotic-resistant bacteria
Frère, Jean-Marie ULg; Rigali, Sébastien ULg

in Drug Target review (2016)

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See detailReal-time remedial action against aperiodic small signal rotor angle instability
Weckesser, Johannes ULg; Jóhannsson, Hjörtur; Østergaard, Jacob

in IEEE Transactions on Power Systems (2016), 31(1), 387-396

This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable ... [more ▼]

This paper presents a method that in real-time determines remedial actions, which restore stable operation with respect to aperiodic small signal rotor angle stability (ASSRAS) when insecure or unstable operation has been detected. An ASSRAS assessment method is used to monitor the stability boundary for each generator in real-time. The ASSRAS boundary represents the condition when a generator reaches the maximum steady state active power injection. The proposed control method exploits analytically derived expressions for the ASSRAS boundary and other characteristic curves in the injection impedance plane to determine an active power redispatch among selected generators to restore stable and secure operation. Since the method is purely based on analytically derived expression, the computation of the remedial actions is fast and well suited for real-time operation. The method was tested on the IEEE 14-bus and the Nordic32 test systems where results show that the method can efficiently determine the required active power redispatch to avoid an imminent instability. [less ▲]

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See detailConditional portfolio allocation: Does aggregate market liquidity matter?
Bazgour, Tarik ULg; Heuchenne, Cédric ULg; Sougné, Danielle ULg

in Journal of Empirical Finance (2016), 35

This paper investigates how aggregate liquidity influences optimal portfolio allocations across various US characteristic portfolios. We consider short-term allocation problems, with single and multiple ... [more ▼]

This paper investigates how aggregate liquidity influences optimal portfolio allocations across various US characteristic portfolios. We consider short-term allocation problems, with single and multiple risky assets, and use the nonparametric approach of Brandt (1999) to directly express optimal portfolio weights as functions of aggregate liquidity shocks. We find, first, that the effect of aggregate liquidity is positive and decreasing with the investment horizon. Second, at daily and weekly horizons, this effect is weaker on allocations in large stocks and gets stronger as we move toward small stocks, regardless of the other stock characteristics, suggesting that liquidity is the main concern of very short-term investors. Third, conditional allocations in risky assets decrease and exhibit shifts toward more liquid assets as aggregate liquidity worsens. Overall, conditioning on aggregate liquidity yields empirical results that are consistent with the so-called flight-to-safety and flight-to-liquidity episodes. Finally, we propose a simple tactical investment strategy and show how aggregate liquidity information can be exploited to enhance the out-of-sample performance of long-term strategies. [less ▲]

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See detailTea production between contract and none contract farmers in Phu Tho Province of Vietnam
Le Thi Kim, Oanh ULg; Bui Thi, Nga; Lebailly, Philippe ULg

in Scholars Journal of Agriculture and Veterinary Sciences (2016), 3(2), 117-122

Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as ... [more ▼]

Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as low farm management, disease control, etc. Of which, tea consumption is considered to be the most challenge and the main reasons is the low cooperation between farmers and other stakeholders in the tea value chain. This study aims to look more deeply and find out the linkage and benefit of farmers in the model of cooperation between farmers and tea processing company through contract and none contract tea production in the study site. The results shown that the contract farming in tea production in the study sites was still not tightened and did not reflect clearly its real roles. However, it was gradually reflected it s roles as the fully contract farmers (worker farmers) received the highest productivity, turnover and value added and the most satisfied, the contract farmers (partly contract) achieved not as high benefit but quite satisfied with their results and contract. None contract farmers although received reasonable results recently but they still did not assure the production, they would like to engage in some kinds of cooperation in the future. [less ▲]

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See detailDiboson anomaly: Heavy Higgs resonance and QCD vector-like exotics
Aristizabal Sierra, Diego ULg; Vicente, Avelino; Herrero-Garcia, Juan et al

in Physical Review. D : Particles and Fields (2016), 93

The ATLAS collaboration (and also CMS) has recently reported an excess over Standard Model expectations for gauge boson pair production in the invariant mass region 1.8−2.2 TeV. In the light of these ... [more ▼]

The ATLAS collaboration (and also CMS) has recently reported an excess over Standard Model expectations for gauge boson pair production in the invariant mass region 1.8−2.2 TeV. In the light of these results, we argue that such signal might be the first manifestation of the production and further decay of a heavy CP-even Higgs resulting from a type-I Two Higgs Doublet Model. We demonstrate that in the presence of colored vector-like fermions, its gluon fusion production cross section is strongly enhanced, with the enhancement depending on the color representation of the new fermion states. Our findings show that barring the color triplet case, any QCD "exotic" representation can fit the ATLAS result in fairly large portions of the parameter space. We have found that if the diboson excess is confirmed and this mechanism is indeed responsible for it, then the LHC Run-2 should find: (i) a CP-odd scalar with mass below ∼2.3 TeV, (ii) new colored states with masses below ∼2 TeV, (iii) no statistically significant diboson events in the W±Z channel, (iv) events in the triboson channels W±W∓Z and ZZZ with invariant mass amounting to the mass of the CP-odd scalar. [less ▲]

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See detailCombined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et al

in Ann Rheum Dis (2016), 75(1), 37-44

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]

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See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

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See detailCholesterol deficiency causing calf illthrift and diarrhoea.
Duff, J. P.; Passant, S.; Wessels, M. et al

in The Veterinary record (2016), 178(17), 424-5

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See detailInsecticidal activity of Lavandula angustifolia Mill. against the pea aphid Acyrtosiphum pisum
Attia, Sabrine; Lognay, Georges ULg; Heuskin, Stéphanie ULg et al

in Journal of Entomology and Zoology Studies (2016), 4(1), 118-122

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most ... [more ▼]

The essential oil of Lavandula angustifolia was investigated for its biocide activity against Acyrtosiphum pisum by fumigation. The oil was characterised by GC-MS revealing that linalool was the most abundant component (38.57%), followed by linalyl acetate (29.95%), 1,8-cineole (13,66%), camphor (13,13%), -pinene (3,14%) and terpinene-4-ol (1,54%). The Mortality was measured upon treatment with oil concentrations ranging from 5 to 25 µl.l-1 of air. The mortality of aphids increased with oil concentration and LC50 values were determined to be 11.2 µl.l-1 of air. The full mixture was also prepared and toxicity was compared with individual constituents. The results showed that the presence of all constituents were necessary to equal the toxicity of the natural oils L. angustifolia oil can provide valuable pesticide activity with significantly lower LC50 values [less ▲]

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See detailEmpédocle, ou comment entrer en philosophie. Sartre et la pensée allemande dans les années 1920
Cormann, Grégory ULg

in Etudes Sartriennes (2016), 20

Comment Sartre est-il entré en philosophie ? Au-delà des petits récits légendaires, tels que ceux que Raymond Aron a laissés à propos de la découverte de la phénoménologie ou de la première formulation de ... [more ▼]

Comment Sartre est-il entré en philosophie ? Au-delà des petits récits légendaires, tels que ceux que Raymond Aron a laissés à propos de la découverte de la phénoménologie ou de la première formulation de la théorie de la contingence pendant les années passées à l’ENS, le présent article vise à établir les conditions dans lesquelles Sartre a formulé à son origine le projet de faire œuvre de philosophe. En pistant le réseau de curiosité intellectuelle pour la pensée allemande dont le titre du manuscrit Empédocle atteste, cet article reconstitue d’abord le milieu intellectuel dans lequel Sartre évolue au milieu des années 1920 avec ses camarades Aron et Nizan, autour des activités du Groupe d’Information Internationale de l’École Normale Supérieure. Comme les Carnets et Les Mots le confirment dans l’après-coup, ce milieu intellectuel fortement « alsacien » lui permet tout à la fois de prolonger et de compliquer – jusqu’à la rupture, peut-être – la vocation à la fois pédagogique et critique que charriait son inscription dans une histoire intellectuelle double, française et allemande. Dans cette étude de la « sociabilité alsacienne » du jeune Sartre et de son rapport avec les premières générations de la germanistique française, la figure de Robert Minder (1902-1980) sert de point de comparaison avec Sartre. La suite de l’article précise la nature du projet philosophique de Sartre dans le rapport qu’il entretient avec la vocation littéraire qui l’a attiré vers des études de philosophie. Dans cette partie, c’est la rencontre personnelle et théorique de Sartre avec Bernard Groethuysen (1880-1946) qui sert de guide. La trajectoire du philosophe allemand permet tout à la fois à Sartre d’articuler la littérature et la philosophie (dans un espace de circulation culturelle franco-allemand) et d’amorcer le passage de l’exigence nietzschéenne d’un recommencement de la philosophie (qui vaut aussi pour l’après-Première Guerre mondiale) avec le programme d’une philosophie rigoureuse déjà incarné chez Groethuysen par la phénoménologie de Husserl. En conclusion, l’article revient sur la façon dont Sartre récupère la situation particulière dans laquelle il rédige son Empédocle – son histoire amoureuse avec Simone Jollivet – en direction d’une philosophie qui expose non seulement le philosophe à une enquête permanente sur soi (Victor Hugo prenant alors le relais de Nietzsche), mais qui soit aussi une entreprise philosophique nouvelle qui conteste de l’intérieur, en la poussant dans ses conséquences extrêmes, la généalogie héroïque – et masculiniste – dont elle est issue. En somme, il s’agit ici, par le truchement d’une lecture symbolique d’un texte de jeunesse, de considérer la philosophie sartrienne au point où elle se précède elle-même, avant la découverte de Heidegger et avant la rencontre de Simone de Beauvoir. Dans cette reconstruction des conditions de possibilité de la philosophie de Sartre – et de Beauvoir – se poursuit dès lors l’entreprise, encore très partiellement réalisée, de faire l’archéologie de la philosophie française contemporaine (selon l’expression d’Alain Badiou) dans l’entre-deux-guerres, à savoir de déterminer la portée critique et historiographique de la phénoménologie existentialiste. [less ▲]

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See detailSound Production by a Recoiling System in the Pempheridae and Terapontidae
Parmentier, Eric ULg; Fine, Michael; Mok, Hin-Kiu

in Journal of Morphology (2016)

Sound-producing mechanisms in fishes are extraordinarily diversified. We report here original mechanisms of three species from two families: the pempherid Pempheris oualensis, and the terapontids Terapon ... [more ▼]

Sound-producing mechanisms in fishes are extraordinarily diversified. We report here original mechanisms of three species from two families: the pempherid Pempheris oualensis, and the terapontids Terapon jarbua and Pelates quadrilineatus. All sonic mechanisms are built on the same structures. The rostral part of the swimbladder is connected to a pair of large sonic muscles from the head whereas the posterior part is fused with bony widenings of vertebral bodies. Two bladder regions are separated by a stretchable fenestra that allows forward extension of the anterior bladder during muscle contraction. A recoiling apparatus runs between the inner face of the anterior swimbladder and a vertebral body expansion. The elastic nature of the recoiling apparatus supports its role in helping the swimbladder to recover its initial position during sonic muscle relaxation. This system should aid fast contraction (between 100 and 250Hz) of sonic muscles. There are many differences between species in terms of the swimbladder and its attachments to the vertebral column, muscle origins, and morphology of the recoiling apparatus. The recoiling apparatus found in the phylogenetically-related families (Glaucosomatidae, Pempheridae, Terapontidae) could indicate a new character within the Percomorpharia. [less ▲]

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See detailThe terrestrialization process: A palaeobotanical and palynological perspective.
Meyer-Berthaud, Brigitte; Servais, Thomas; Vecoli, Marco et al

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 1-3

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailCharacterization of saccharides released during an in vitro pepsin-pancreatin digestion of corn flour using HPAEC-PAD
Odjo, Djosse Psijus Sylvanus ULg; Bera, François ULg; Jacquet, Nicolas ULg et al

in Stärke = Starch (2016), 68

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric ... [more ▼]

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD) and two colorimetric approaches (glucose oxidase/ peroxidase assay and the 3,5-dinitrosalicylic acid assay). HPAEC-PAD revealed five major saccharides as the result of in vitro pepsin-pancreatin digestion of corn grain: glucose, isomaltose, maltose, maltotriose, and glucosyl-maltotriose. Concentrations of glucose released as measured by the three methods assessed are similar when the in vitro pepsin-pancreatin digestion is followed by post incubation with amyloglucosidase. This post incubation unfortunately leads to a loss of information about the degree of polymerization of oligosaccharides that can impact their absorption through intestinal tract. HPAEC-PAD gives both qualitative and quantitative information and then seems more suitable for a nutritional appreciation of the digestion of starchy feedstuffs. [less ▲]

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See detailMigration, prostitution and the representation of the black female subject in Nigerian video films about Italy
Jedlowski, Alessandro ULg

in Journal of Italian Cinema and Media Studies (2016), 4(1), 9-23

Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the ... [more ▼]

Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the white male gaze. In this sense, Ponzanesi’s call for ‘new and less biased representations, which could help to assess the multiple subject positions that black identities now occupy’ (2005: 179) is still relevant. This article responds to this call by analyzing two Nigerian video films that thematize migration and prostitution trafficking in Italy. By highlighting the complexity of the processes of ‘subjectivation’ taking place throughout the migratory process, these videos invite their viewers to look at the postcolonial subject’s responsibility in shaping the world in which s/he lives, and offer a representation of the black female subject able to go beyond the voyeuristic attitude that characterize much of the existing contemporary Italian visual culture about this topic. [less ▲]

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See detailChemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds
Talla, Emmanuel; Yaya Gbaweng, Joël; Mokale, Laurel et al

in Natural Products : An Indian Journal (2016), 12(1), 12-20

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2 ... [more ▼]

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2), erythrinasinate A (3), erythrinasinate B (4), abyssinone-IV-4'-methylether (5), erythrabyssin (6), phaseollidin (7), 4’-methoxylicoflavanone (8) and abyssinone-V-4'-methylether (9) respectively from methanolic extract of roots wood and EtOAc extract of roots bark of the same plant. Their structures were elucidated using spectroscopic methods (MS, NMR and IR) and by comparison with some data found in literature. Free radical scavenging (DPPH) and antibacterial potentials of extracts and compounds were also evaluated in this work. For radical scavenging, results showed that it is phaseollidin (7) which is responsible of radical scavenging potential in the ethyl acetate extract of roots barks with value of 1.31 mg/ml; for antibacterial, one of the tested compounds abyssinone-IV-4'-methylether (5) exhibited antibacterial activities against two strains: Providencia stuartiiATCC 29916 and Enterobacter aerogenes ATCC 13048 with MIC values of 25μg/ml. [less ▲]

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See detailClinical sentinel surveillance of equine West Nile fever, Spain
Saegerman, Claude ULg; Alba-Casals, A; Garcia-Bocanegra, I et al

in Transboundary and Emerging Diseases (2016), 63(2), 184-193

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See detailDementia-specific quality of life instruments: a conceptual analysis
Missotten, Pierre ULg; Dupuis, Gilles; Adam, Stéphane ULg

in International Psychogeriatrics (2016)

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the ... [more ▼]

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the conceptual frameworks of the dementia-specific QoL instruments, to identify their evolution over time and to provide elements of reflection on the QoL concept in dementia and its evaluation. Method: An electronic search was conducted on PsycINFO and MEDLINE databases, from January 1985 to June 2015 using a combination of key words that include quality of life, dementia and review. Result: The analysis of the conceptual frameworks of the eighteen selected dementia-specific QoL tools shows a great diversity in: (1) the QoL definitions (e.g. health-related QoL definitions, QoL definitions based on Lawton’s work or similar to this latter); (2) the theoretical QoL models (e.g. Lawton’ work and modified Lawton, adaptation, personhood); (3) the domains and dimensions; (4) the way to construct the instrument (e.g. development based on literature, opinion of the experts) and (5) the items’ formulation (e.g. use of criterion of intensity or frequency). Conclusion: There are different conceptual frameworks in the dementia-specific QoL measures with improvements over time (e.g. inclusion of interesting concepts such as adaptation, taking into account the views of patients themselves). Each of the conceptual parameters (definitions, models, domains and dimensions) is discussed to identify the scales that are conceptually the strongest. Through their review, recommendations for future instrument refinement and development are discussed and a new QoL definition is proposed. [less ▲]

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See detail[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
WITHOFS, Nadia ULg; Martinive, Philippe ULg; VANDERICK, Jean ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]

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See detailStratigraphy and depositional environments of the Late Famennian (Late Devonian) of Southern Belgium and characterization of the Strud locality
Denayer, Julien ULg; Prestianni, Cyrille; Gueriau, Pierre et al

in Geological Magazine (2016), 153(1), 112-127

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods ... [more ▼]

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods. The Strud locality has yielded a diverse flora and fauna including seed-plants, tetrapods, various placoderm, actinopterygian, acanthodian and sarcopterygian fishes, crustaceans (anostracans, notostracans, conchostracans and decapods) and a putative complete insect. This fossil assemblage is one of the oldest continental – probably fresh-water – ecosystems with a considerable vertebrate and invertebrate diversity. The study of the palaeoenvironment of the Strud locality is crucial because it records one of the earliest and most important phases of tetrapod evolution that took place after their emergence but before their terrestrialization. It raises the question of environmental and ecological conditions for the Devonian aquatic ecosystem and the selection pressures occurring at the onset of tetrapod terrestrialization. The present study characterized the fluvial facies of the Upper Famennian sedimentary rocks of Strud and the surrounding areas. The exceptional preservation of arthropods and plants in the main fossiliferous layers is explained by rapid burial in the fine-grained sediment of the quiet and confined flood plain environment. Newly investigated fossiliferous sections in the Meuse–Samson area led to the description and correlation of key sections (Strud, Wierde and Jausse sections, complemented by the less continuous Haltinne, Huy and Coutisse sections). Moreover, the investigated sections allowed a review of the age of the fossiliferous horizon, which is now definitely considered to be Late Famennian in age. [less ▲]

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See detailDe la matérialisation de quelques concepts phénoménologiques.
Frère, Bruno ULg

in SociologieS (2016)

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été ... [more ▼]

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été d’usage mais s’avère aujourd’hui urgent. En effet, faisant l’économie d’une considération sérieuse de la prise que lui offre la sociologie sur le monde, la philosophie risque d’échouer à penser les transformations politiques et économiques des société contemporaines. A l’inverse, une certaine tendance positiviste semble menacer la sociologie qui se débarrasserait de toutes connaissances philosophiques. Afin de rappeler l’intérêt que l’une et l’autre se doivent réciproquement, cet article voudrait montrer comment il peut être utile à la sociologie de donner corps à certains concepts philosophiques lorsqu’elle s’avère confrontée à certaines difficultés. Afin d’illustrer le propos, nous nous référerons à un exemple puisé au sein de l’économie solidaire. Ici en effet, c’est en acceptant que se matérialise dans l’enquête le concept d’état d’esprit intentionnel que la philosophie phénoménologique vient à point nommé pour aider la sociologie pragmatique de la critique à se représenter les contradictions qui peuvent apparaître entre action et justification. Et ce sans pour autant renoncer à « prendre les gens aux sérieux » et s’en retourner vers une traditionnelle sociologie du dévoilement qui expliquerait ces contradictions par le décalage qui existerait entre habitus (ou sens pratique) d’une part et illusions réflexives des acteurs d’autre part. Mots clefs : phénoménologie, états d’esprit intentionnel, philosophie, sociologie pragmatique, économie solidaire. Summary : This article is a reflexion about the relationship between sociology and philosophy. It will show that building bridges between the two disciplines, whilst recurrent, is more urgent now than ever. On the one hand, philosophy will be unable to contribute meaningfully to discussions about the major political and economic transformations experienced by contemporary societies without engaging with Sociology. On the other hand without philosophical insights Sociology risks drifting towards positivistic trends. In this article we propose to show how each discipline can benefit from cross-fertilisations and in particular how Sociology can appropriate philosophical concepts to address certain challenges. Drawing on a specific example from solidary economy, we will show that the concept of intentional mindset borrowed from phenomenological philosophy enables pragmatic sociology to account for the gaps which are liable to emerge between action and justification. This concept fulfills the key tenet of pragmatic sociology that to take social actors seriously we must eschew a type of sociological approach which would consist of revealing that the gaps between action and justification arise from social actors’ illusory apprehension of their habitus. Key words: phénoménology, mindset, states of mind, philosophy, pragmatic sociology, solidarity economy. [less ▲]

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See detail"Translating Multilayered Sensory Experience"
Bada, Valérie ULg; Pagnoulle, Christine ULg

in Palimpsestes (2016)

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory ... [more ▼]

The powerful impact of the plays by African American playwright August Wilson largely relies on the way his words appeal to the senses, whether explicitly by calling upon the characters’ sensory experience or more indirectly through his use of syntactic rhythm, or indeed his specific modulation of AAVE. This article describes how the translators tried to create a French idiom that induces the same sensory impact on an audience and, at the same time, reflects the multilayered referentiality of the text. [less ▲]

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See detailMechanical behaviour of tape springs used in the deployment of reflectors around a solar panel
Dewalque, Florence ULg; Collette, Jean-Paul; Bruls, Olivier ULg

in Acta Astronautica (2016), 123

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this ... [more ▼]

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this work, reflectors are deployed by the means of compliant mechanisms known as tape springs. Their attractive characteristics are, among others, their passive behaviour, their self-locking capacity, their elastic deformations and their robustness. However, their mechanical behaviour is highly nonlinear and requires thorough analyses in order to develop predictive numerical models. It is shown here through parametric studies that the nonlinear behaviour of a tape spring is mainly governed by its geometry. Thus, for each specific application, its dimensions can be determined in order to minimise two critical features: the maximum stress affecting the structure and the maximum motion amplitude during deployment. In this paper, an optimisation procedure is proposed to meet these requirements. [less ▲]

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See detailSulfur solubility in reduced mafic silicate melts: Implications for the speciation and distribution of sulfur on Mercury
Namur, Olivier; Charlier, Bernard ULg; Holtz, Francois et al

in Earth and Planetary Science Letters (2016), 448

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See detailThe effect of insulin on plasma glucose concentrations, expression of hepatic glucose transporters and key gluconeogenic enzymes during the perinatal period in broiler chickens
Franssens, L.; Lesuisse, J.; Wang, Yuan ULg et al

in General and Comparative Endocrinology (2016)

Chickens have blood glucose concentrations that are twofold higher than those observed in mammals. Moreover, the insulin sensitivity seems to decrease with postnatal age in both broiler and layer chickens ... [more ▼]

Chickens have blood glucose concentrations that are twofold higher than those observed in mammals. Moreover, the insulin sensitivity seems to decrease with postnatal age in both broiler and layer chickens. However, little is known about the response of insulin on plasma glucose concentrations and mRNA abundance of hepatic glucose transporters 1, 2, 3, 8, 9 and 12 (GLUT1, 2, 3, 8, 9 and 12) and three regulatory enzymes of the gluconeogenesis, phosphoenolpyruvate carboxykinase 1 and 2 (PCK1 and 2) or fructose-1,6-biphosphatase 1 (FBP1) in chicks during the perinatal period. In the present study, broiler embryos on embryonic day (ED)16, ED18 or newly-hatched broiler chicks were injected intravenously with bovine insulin (1. μg/g body weight (BW)) to examine plasma glucose response and changes in hepatic mRNA abundance of the GLUTs, PCK1 and 2 and FBP1. Results were compared with a non-treated control group and a saline-injected sham group. Plasma glucose levels of insulin-treated ED18 embryos recovered faster from their minimum level than those of insulin-treated ED16 embryos or newly-hatched chicks. In addition, at the minimum plasma glucose level seven hours post-injection (PI), hepatic GLUT2, FBP1 and PCK2 mRNA abundance was decreased in insulin-injected embryos, compared to sham and control groups, being most pronounced when insulin injection occurred on ED16. © 2015 Elsevier Inc. [less ▲]

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See detailConvective drying behavior of sawdust-sludge mixtures in a fixed bed
Li, Jie; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Drying Technology (2016), 34(4), 395-402

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See detailSludge dewatering and drying: about the difficulty of making experiments with a non-stabilized material
Pambou, Yvon-Bert ULg; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Desalination and Water Treatment (2016), 57(30), 13841-13856

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See detailCrystallization and polymorphic behavior of enzymatically produced sunflower oil based cocoa butter equivalents
Kadiva, Sheida; De Clercq, Nathalie; Danthine, Sabine ULg et al

in European Journal of Lipid Science and Technology [=EJLST] (2016), 118

A multi-methodological approach was used to study the isothermal crystallization of cocoa butter (CB) in the presence of sunflower oil based cocoa butter equivalents (CBEs). pNMR, DSC, oscillatory ... [more ▼]

A multi-methodological approach was used to study the isothermal crystallization of cocoa butter (CB) in the presence of sunflower oil based cocoa butter equivalents (CBEs). pNMR, DSC, oscillatory rheology, XRD, and PLM were used for this purpose. All the techniques confirmed that at 20°C isothermal crystallization of all the blends is a two-step process with formation of α crystals in the first step and formation of β’ crystals in the second step. The blends with high amount of CBEs contained more high-melting triacylglycerols (TAGs) and diacylglycerol (DAG) in compare with CB acting as seed crystals enhancing the formation of a- crystals in the first crystallization step. Therefore, the induction time of the first crystallization step was inversely related to the amount of CBE. In contrast, the subsequent polymorphic transition was delayed by the presence of the CBE due to their low-melting TAGs. However, adding up to 5% CBE did not change the Foubert’s parameters for isothermal crystallization significantly. All the blends (except 5% HOSO CBE), had a mediated β’ crystallization. Picturing of the microstructure showed that for the CB and the blends up to 50% large microstructures, indicative of the bV polymorph developed during storage. At 100%, a dense network of spherulites was formed at the beginning of the crystallization period, but upon further storage, no large morphological changes were observed. Practical applications: In recent years, the production of CB has been delayed owing to its cultivation difficulty and low yield due to pest attack, while the world cocoa prices have increased with rising demand and higher chocolate consumption. Therefore, there is a need to develop low-priced and appropriate alternatives to CB. Accordingly, in this study two sunflower oil based CBEs were produced with fatty acid mixtures in the presence of immobilized 1,3-regiospecific lipase. The results from this study could help the fats and oils industries to extend their knowledge on the crystallization and polymorphic behavior of two enzymatically produced sunflower oil based CBEs. [less ▲]

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See detailEarthquake imprints on a lacustrine deltaic system: the Kürk Delta along the East Anatolian Fault (Turkey)
Hubert, Aurelia ULg; El Ouahabi, Meriam ULg; Garcia-Moreno, David et al

in Sedimentology (2016)

Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures ... [more ▼]

Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures. The Kürk lacustrine delta lies at the south-western extremity of Lake Hazar in eastern Turkey and is adjacent to the seismogenic East Anatolian Fault (EAF), which has generated earthquakes of magnitude 7. In this paper we have reevaluated water level changes and earthquake shaking that have affected the Kürk Delta combining geophysical data (seismic-reflection profiles and side-scan sonar), remote sensing images, historical data, onland outcrops and offshore coring. The history of water level changes provides a temporal framework for the depositional record. In addition to the commonly soft-sediment-deformation documented previously, onland outcrops reveal a record of deformation (fracturing, tilt and clastic dykes) linked to large earthquake-induced liquefactions and lateral spreading. The recurrent liquefaction structures can be used to obtain a paleoseismological record. Five event horizons were identified that could be linked to historical earthquakes occurring in the last 1000 years along the EAF. Sedimentary cores sampling the most recent subaqueous sedimentation revealed the occurrence of another type of earthquake indicator. Based on radionuclide dating (137Cs and 210Pb), two major sedimentary events were attributed to the 1874-1875 EAF earthquake sequence. Their sedimentological characteristics were determined by X-ray imagery, XRD, LOI, grain-size distribution and geophysical measurements. The events are interpreted to be hyperpycnal deposits linked to post-seismic sediment reworking of earthquake-triggered landslides. [less ▲]

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See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2),

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

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See detailPartial ages: diagnosing transport processes by means of multiple clocks.
Mouchet, Anne ULg; Cornaton, Fabien; Deleersnijder, Eric et al

in Ocean Dynamics (2016), 66

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See detailA pilot double-blind, randomized, placebo-controlled trial of the efficacy of trace elements in the treatment of endometriosis-related pain: study design and methodology
OBERWEIS, Didier; MANDELENAT, Patrick; Nisolle, Michelle ULg

in Nutrition and Dietary Supplements (2016), 8

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various ... [more ▼]

Endometriosis is one of the most common benign gynecological disorders, affecting almost 10%–15% of all women of reproductive age and .30% of infertile women. The pathology is associated with various distressing symptoms, particularly pelvic pain, which adversely affect patients’ quality of life. It is an estrogen-dependent disease. There is evidence both in animals and in humans that metal ions can activate the estrogen receptors. They are defined as a variety of xenoestrogens, called metalloestrogens, which could act as endocrine disruptors. Therefore, it could be considered to act on this gynecological disorder using food supplements containing trace elements (ie, nutripuncture). The assumption is that they could modulate estrogen receptors and thus influence the tropism and the survival of cells involved in endometriosis. By a modulation of the antioxidant system, they might also interact with various parameters influencing tissue biochemistry. The objective of this article is to describe and discuss the design and methodology of an ongoing double-blind, randomized, placebo-controlled study aiming to evaluate the efficacy of metal trace elements on the reduction of pain and improvement of quality of life, in patients with a revised American Fertility Society Score Stages II–IV endometriosis, combined or not with adenomyosis, during a treatment period of 4 months. Trace elements or placebo is proposed in the absence of any other treatment or as an add-on to current therapies, such as sexual hormones, nonsteroidal anti-inflammatory drugs, and surgery. A placebo run-in period of one menstrual cycle or 30 days for women in amenorrhea has been scheduled to eliminate the patients who are responding too much to the placebo. After a 1:1 ratio randomization on Day 0, the treatment with trace elements or placebo will last for 4 monts (120 days). [less ▲]

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See detailL’impact des activités non agricoles sur la pauvreté et l’inégalité rurales dans les groupements Bugorhe et Irhambi-Katana (Territoire de Kabare, Province du Sud-Kivu)
Furaha Mirindi, Germaine ULg; Namegabe Mastaki, Jean Luc; Lebailly, Philippe ULg

in JOURNAL OF ORIENTAL AND AFRICAN STUDIES (2016), 25

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of ... [more ▼]

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of Congo, by comparing a group of households practicing agriculture only and another group which combines agriculture and nonfarm activities. The approach used considers non farm income as an exogenous transfer which completes the whole household income, and analyses the contribution of different sources of income on the inequality in using the Gini index. The results show that inequality increases when a segment of the population does not have access to non-agricultural income. In this case, non farm income is not a substitute of farm income, rather the complement. The poverty analysis is based on the Congolese rural threshold poverty in terms of basic needs to calculate the rate, depth and severity of poverty indexes in using of Foster- Greer-Thorbecke. The results show that households practicing agriculture only are poorer. [less ▲]

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See detailProbing the low-frequency vortex dynamics in a nanostructured superconducting strip
de Souza Silva, Clecio C.; Raes, Bart; Brisbois, Jérémy ULg et al

in Physical Review B (2016)

We investigate by scanning susceptibility microscopy the response of a thin Pb strip, with a square array of submicron antidots, to a low-frequency ac magnetic field applied perpendicularly to the film ... [more ▼]

We investigate by scanning susceptibility microscopy the response of a thin Pb strip, with a square array of submicron antidots, to a low-frequency ac magnetic field applied perpendicularly to the film plane. By mapping the local permeability of the sample within the field range where vortices trapped by the antidots and interstitial vortices coexist, we observed two distinct dynamical regimes occurring at different temperatures. At a temperature just below the superconducting transition, T/Tc = 0.96, the sample response is essentially dominated by the motion of highly mobile interstitial vortices. However, at a slightly lower temperature, T/Tc = 0.93, the interstitial vortices freeze up leading to a strong reduction of the ac screening length. We propose a simple model for the vortex response in this system which fits well to the experimental data. Our analysis suggests that the observed switching to the high mobility regime stems from a resonant effect, where the period of the ac excitation is just large enough to allow interstitial vortices to thermally hop through the weak pinning landscape produced by random material defects. This argument is further supported by the observation of a pronounced enhancement of the out-of-phase response at the crossover between both dynamical regimes. [less ▲]

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See detailMises en scènes auctoriales autour de la publication d'Oedipe
Daubercies, Laurence ULg

in Revue Voltaire (2016), 16

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