References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 901 to 1000 of 46767     5 6 7 8 9 10 11 12 13 14 15     Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathologyStygelbout, V.; Leroy, K.; Pouillon, V. et alin Brain : A Journal of Neurology (2014), 137S. Schurmans and J.-P. Brion contributed equally to this work Corresponding author: S. Schurmans, Laboratoire de Génétique Fonctionnelle, GIGA-Research Centre, Building 34, Université de Liège, rue de ... [more ▼]S. Schurmans and J.-P. Brion contributed equally to this work Corresponding author: S. Schurmans, Laboratoire de Génétique Fonctionnelle, GIGA-Research Centre, Building 34, Université de Liège, rue de l’Hôpital 1, 4000-Liège, Belgium. Abstract: Inositol (1,4,5) trisphosphate 3-kinase B phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate and controls signal transduction in various hematopoietic cells. Surprisingly, it has been reported that Inositol (1,4,5) trisphosphate 3-kinase B mRNA level is significantly increased in the cerebral cortex of Alzheimer patients, compared to control subjects. Since Extracellular signal-regulated kinases 1/2 activation is increased in Alzheimer brain and since Inositol (1,4,5) trisphosphate 3-kinase B is a regulator of Extracellular signal-regulated kinases 1/2 activation in some hematopoietic cells, we tested whether this increased activation in Alzheimer’s disease might be related to an increased activity of Inositol (1,4,5) trisphosphate 3-kinase B. We show here that Inositol (1,4,5) trisphosphate 3-kinase B protein level was 3 fold increased in the cerebral cortex of most Alzheimer patients, compared to control subjects, and accumulated in dystrophic neurites associated to amyloid plaques. In mouse Neuro-2a neuroblastoma cells, Inositol (1,4,5) trisphosphate 3-kinase B overexpression was associated with increased cell apoptosis and increased β-secretase 1 activity leading to amyloid-β peptides overproduction. In this cellular model, an inhibitor of Mitogen-activated kinase kinases 1/2 completely prevented amyloid-β peptides overproduction. Transgenic overexpression of Inositol (1,4,5) trisphosphate 3-kinase B in mouse forebrain neurons was not sufficient to induce amyloid plaques formation or TAU hyperphosphorylation. However, in the 5X Familial Alzheimer’s Disease mouse model, neuronal Inositol (1,4,5) trisphosphate 3-kinase B overexpression significantly increased Extracellular signal-regulated kinases 1/2 activation and β-secretase 1 activity, resulting in exacerbated Alzheimer pathology as shown by increased astrogliosis, amyloid-β40 peptide production and TAU hyperphosphorylation. No impact on pathology was observed in the 5X Familial Alzheimer’s Disease mouse model when a catalytically inactive Inositol (1,4,5) trisphosphate 3-kinase B protein was overexpressed. Together, our results point to the Inositol (1,4,5) trisphosphate 3-kinase B /Inositol 1,3,4,5-tetrakisphosphate/Extracellular signal-regulated kinases 1/2 signaling pathway as an important regulator of neuronal cell apoptosis, Amyloid precursor protein processing and TAU phosphorylation in Alzheimer’s disease, and suggest that Inositol (1,4,5) trisphosphate 3-kinase B could represent a new target for reducing pathology in human AD patients with increased cortical Inositol (1,4,5) trisphosphate 3-kinase B expression. [less ▲]Detailed reference viewed: 32 (14 ULg) Évaluation du potentiel de dix accessions de Jatropha curcas L. (Euphorbiaceae) au NigerAbdoul Habou, Zakari; Katkore, Boubacar; Abasse, Tougiani et alin Journal of Applied Biosciences (2014), 77Objective: A trial of the ten accessions for J curcas was carried out at regional Agricultural Research Center of Maradi in Niger, with aim to evaluate the performance of Jatropha curcas accessions ... [more ▼]Objective: A trial of the ten accessions for J curcas was carried out at regional Agricultural Research Center of Maradi in Niger, with aim to evaluate the performance of Jatropha curcas accessions. Methodology and results: Each accession was represented by two rows and each row has 15 plant trees of J. curcas. Data on the rate of survival and growth parameters of each tree were collected. Results revealed that there is no significant difference between accessions tested for height and diameter. Accessions Katil 13 and GB 14 respectively originated from Mali and Bisseau Guinea were best adapted for the Niger conditions. The yield value of 511 and 445 kg per hectare respectively obtained from Katil 13 and GB 14 in 2012.Conclusion and application of results: The Government of Niger has drawn attention to this crop and has launched a J. curcas plantation for seed production of 150 ha at Guessalbodi. National Research Institution. NGOs are also involved in J. curcas plantation for biofuel use. [less ▲]Detailed reference viewed: 19 (0 ULg) Osteonecrosis of the jaw in a male osteoporotic patient treated with denosumabNEUPREZ, Audrey ; Coste, S; Rompen, Eric et alin Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]Detailed reference viewed: 43 (14 ULg) Fragmentation and isomerization due to field heating in traveling wave ion mobilityMorsa, Denis ; Gabelica, Valérie ; De Pauw, Edwin in Journal of the American Society for Mass Spectrometry (2014), 25(6), 1384-1393During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T ... [more ▼]During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T eff,vib obtained at the injection and inside the mobility cell of a SYNAPT G2 HDMS spectrometer for different probe ions: benzylpyridinium ions and leucine enkephalin. Using standard parameter sets, we obtained a temperature of ~800 K at injection and 728 ± 2 K into the IMS cell for p-methoxybenzylpyridinium. We found that T eff,vib inside the cell was dependent on the separation parameters and on the nature of the analyte. While the mean energy of the Boltzmann distributions increases with ion size, the corresponding temperature decreases because of increasing numbers of vibrational normal modes. We also investigated conformational rearrangements of 7+ ions of cytochrome c and reveal isomerization of the most compact structure, therefore highlighting the effects of weak heating on the gas-phase structure of biologically relevant ions. [less ▲]Detailed reference viewed: 6 (1 ULg) Sarapis et Neôtera élus parmi les dieuxVeymiers, Richard in Revue Archéologique (2014), (1), 37-56One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and ... [more ▼]One of the bronze plates formerly in the Bianchini collection, which entered the Cabinet des Médailles (Paris) at the end of the 18th century, bears a text and an image, supposedly unintelligible and therefore thought to be of a magic nature. A new examination of this artefact, actually the main part of a bracelet, shows that it depicts an assembly of twenty-eight divinities, illustrating the religious landscape of Egypt in the 2nd-3rd century, and that it is inscribed with two short acclamations. The first one exalts the greatness of the name of Sarapis, the second that of Neôtera the invincible. The identity of this goddess is difficult to define, but she often seems to correspond to a form of Isis assimilated to Korè. The glorifying invocation of these two gods, depicted with their pantheon, may be considered to be an expression of what is today called “megatheism”. [less ▲]Detailed reference viewed: 61 (0 ULg) Pulmonary rehabilitation and COPD: providing patients a good environment for optimizing therapy.Corhay, Jean-Louis ; NGUYEN DANG, Delphine ; VAN CAUWENBERGE, Hélène et alin International journal of chronic obstructive pulmonary disease (2014), 9Chronic obstructive pulmonary disease (COPD) is an obstructive and progressive airway disease associated with an important reduction in daily physical activity and psychological problems that contribute ... [more ▼]Chronic obstructive pulmonary disease (COPD) is an obstructive and progressive airway disease associated with an important reduction in daily physical activity and psychological problems that contribute to the patient's disability and poor health-related quality of life (HRQoL). Nowadays, pulmonary rehabilitation (PR) plays an essential role in the management of symptomatic patients with COPD, by breaking the vicious circle of dyspnea-decreased activity-deconditioning-isolation. Indeed the main benefits of comprehensive PR programs for patients with COPD include a decrease in symptoms (dyspnea and fatigue), improvements in exercise tolerance and HRQoL, reduction of health care utilization (particularly bed-days), as well as an increase in physical activity. Several randomized studies and meta-analyses greatly established the benefits of PR, which additionally, is recommended in a number of influential guidelines. This review aimed to highlight the impact of PR on COPD patients, focusing on the clinical usefulness of PR, which provides patients a good support for change. [less ▲]Detailed reference viewed: 10 (2 ULg) Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.Scheen, André in Expert opinion on drug metabolism & toxicology (2014)Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]Detailed reference viewed: 18 (1 ULg) Surgery for severe ischemic mitral regurgitation.Magne, Julien; Pierard, Luc in The New England journal of medicine (2014), 370(15), 1462Detailed reference viewed: 3 (0 ULg) Development of the simultaneous detection of Ralstonia solanacearum race 3 and clavibacter michiganensis subsp. Sepedonicus in potato tubers by a multiplex real-time PCR assayMassart, Sébastien ; Nagy, Catherine; Jijakli, Haissam in European Journal of Plant Pathology (2014), 138Detailed reference viewed: 13 (0 ULg) Altered Desferrioxamine-mediated Iron Utilization is a Common Trait of bald Mutants of Streptomyces coelicolorLambert, Stéphanie ; Traxler, M. F.; Craig, M. et alin Metallomics (2014)Detailed reference viewed: 16 (1 ULg) Resistance of through-plate component in beam-to-column joints with circular hollow columnsHoang, Van Long ; Demonceau, Jean-François ; Jaspart, Jean-Pierre in Journal of Constructional Steel Research (2014), 92A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to ... [more ▼]A configuration of beam-to-column joint with circular hollow section columns is proposed. A vertical plate, called through-plate, passing through the column is used to support the beams. In order to facilitate connecting the beams, two horizontal plates, each side of the column, are welded to the upper side of the through-plate. The lower flanges of the steel beams are connected to the horizontal plates by bolts, and the upper flanges are attached to the concrete slab by shear connections. The joint is considered as hinges in the construction phase while semi-rigid and partial strength can be adopted for the joint behaviour during the exploitation time. A development on the through-plate component of the joint is presented in this paper. Global behaviour of the joint under hogging moment and shear force is analysed leading to a mechanical model of the through-plate component. Using the elastic buckling theory of plates, the analytical formulas for critical stresses of the through-plate are obtained. The coefficients taking into account boundary conditions, material plasticity and geometrical imperfection are determined by finite element analysis. The proposed model is validated by experimental results showing a good accuracy. The design guideline for the component is finally provided for the practical purpose. [less ▲]Detailed reference viewed: 52 (4 ULg) To settle or to move? The interplay between two classes of cyclic lipopeptides in the biocontrol strain Pseudomonas CMR12aD’aes, J.; Phuong Kieu, N.; Leclère, V. et alin Environmental Microbiology (2014), In pressDetailed reference viewed: 5 (0 ULg) Endocrine disruptors: A relevant issue for neuroendocrinology also!Balthazart, Jacques ; Levine, Jon E.in Frontiers in neuroendocrinology (2014), 35(1), 1Detailed reference viewed: 8 (1 ULg) The relationship between working memory for serial order and numerical development: a longitudinal studyAttout, Lucie ; Noël, Marie-Pascale; Majerus, Steve in Developmental Psychology (2014), 50(6), 1667-1679Detailed reference viewed: 8 (0 ULg) The Dimethylsulfide Cycle in the Eutrophied Southern North Sea: A Model Study Integrating Phytoplankton and Bacterial ProcessesGypens, N; Borges, Alberto ; Speeckaert, Gaëlle et alin Plos One (2014), 9(1)(e85862 DOI: 10.1371/journal.pone.0085862), We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical ... [more ▼]We developed a module describing the dimethylsulfoniopropionate (DMSP) and dimethylsulfide (DMS) dynamics, including biological transformations by phytoplankton and bacteria, and physico-chemical processes (including DMS air-sea exchange). This module was integrated in the MIRO ecological model and applied in a 0D frame in the Southern North Sea (SNS). The DMS(P) module is built on parameterizations derived from available knowledge on DMS(P) sources, transformations and sinks, and provides an explicit representation of bacterial activity in contrast to most of existing models that only include phytoplankton process (and abiotic transformations). The model is tested in a highly productive coastal ecosystem (the Belgian coastal zone, BCZ) dominated by diatoms and the Haptophyceae Phaeocystis, respectively low and high DMSP producers. On an annual basis, the particulate DMSP (DMSPp) production simulated in 1989 is mainly related to Phaeocystis colonies (78%) rather than diatoms (13%) and nanoflagellates (9%). Accordingly, sensitivity analysis shows that the model responds more to changes in the sulfur:carbon (S:C) quota and lyase yield of Phaeocystis. DMS originates equally from phytoplankton and bacterial DMSP-lyase activity and only 3% of the DMS is emitted to the atmosphere. Model analysis demonstrates the sensitivity of DMS emission towards the atmosphere to the description and parameterization of biological processes emphasizing the need of adequately representing in models both phytoplankton and bacterial processes affecting DMS(P) dynamics. This is particularly important in eutrophied coastal environments such as the SNS dominated by high non-diatom blooms and where empirical models developed from data-sets biased towards open ocean conditions do not satisfactorily predict the timing and amplitude of the DMS seasonal cycle. In order to predict future feedbacks of DMS emissions on climate, it is needed to account for hotspots of DMS emissions from coastal environments that, if eutrophied, are dominated not only by diatoms. [less ▲]Detailed reference viewed: 3 (1 ULg) Memory Reactivation During Rapid Eye Movement (REM) Sleep Promotes Its Generalization and Integration in Cortical StoresSterpenich, Virginie; Schmidt, Christina ; Albouy, Genevièvre et alin Sleep (2014), 37(6), 1061-1075Memory reactivation appears to be a fundamental process in memory consolidation. Here, we tested the influence of memory reactivation during REM sleep on memory performance and brain responses at ... [more ▼]Memory reactivation appears to be a fundamental process in memory consolidation. Here, we tested the influence of memory reactivation during REM sleep on memory performance and brain responses at retrieval in healthy human participants. Auditory cues were associated with pictures of faces during their encoding. These memory cues delivered during REM sleep enhanced subsequent accurate recollections but also false recognitions. These results suggest that reactivated memories interacted with semantically-related representations, and induced new creative associations, which subsequently reduced the distinction between new and previously encoded exemplars. Cues had no effect if presented during stage 2 sleep, or if they were not associated with faces during encoding. Functional MRI revealed that following exposure to conditioned cues during REM sleep, responses to faces during retrieval were enhanced both in a visual area and in a cortical region of multisensory (auditory-visual) convergence. These results show that reactivating memories during REM sleep enhances cortical responses during retrieval, suggesting the integration of recent memories within cortical circuits, favoring the generalization and schematization of the information. [less ▲]Detailed reference viewed: 38 (2 ULg) Dorsomedial prefrontal metabolism and unawareness of current characteristics of personality traits in Alzheimer’s diseaseJedidi, Haroun ; Feyers, Dorothée ; Collette, Fabienne et alin Social Cognitive and Affective Neuroscience (2014)Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while ... [more ▼]Anosognosia is a complex symptom corresponding to a lack of awareness of one’s current clinical status. Anosognosia for cognitive deficits has frequently been described in Alzheimer’s disease (AD), while unawareness of current characteristics of personality traits has rarely been considered. We used a well-established questionnaire-based method in a group of 37 AD patients and in healthy controls to probe self- and hetero-evaluation of patients’ personality and we calculated differential scores between each participant’s and his/her relative’s judgments. A brain-behavior correlation was performed using FDG-PET images. The behavioral data showed that AD patients presented with anosognosia for current characteristics of their personality and their anosognosia was primarily explained by impaired third perspective taking. The brain-behavior correlation analysis revealed a negative relationship between anosognosia for current characteristics of personality and dorsomedial prefrontal cortex (dMPFC) activity. Behavioral and neuroimaging data are consistent with the view that impairment of different functions subserved by the dMPFC (self-evaluation, inferences regarding complex enduring dispositions of self and others, confrontation of perspectives in interpersonal scripts) plays a role in anosognosia for current characteristics of personality in AD patients. [less ▲]Detailed reference viewed: 36 (16 ULg) European multicentre validation study of the accuracy of E/e' ratio in estimating invasive left ventricular filling pressure: EURO-FILLING study.Galderisi, Maurizio; Lancellotti, Patrizio ; Donal, Erwan et alin European Heart Journal - Cardiovascular Imaging (2014)AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for ... [more ▼]AIMS: The non-invasive estimation of left ventricular filling pressures (LVFPs) represents a main goal in the clinical setting. Current recommendations encourage the use of pulsed-wave Tissue Doppler for calculating the ratio between the preload-dependent transmitral E velocity and the average of septal and lateral early diastolic velocities (e') of the mitral annulus. Despite its wide use, real utility of the E/e' ratio has been recently challenged in patients with either very advanced heart failure or preserved left ventricular (LV) ejection fraction. However, only few studies performed the invasive and non-invasive estimation of LVFP simultaneously. The EURO-FILLING Study will validate the E/e' ratio (and additional non-invasive estimates) against simultaneously measured LVFP obtained by left heart catheterization in a multicentre study involving reference European echo laboratories collecting a wide population sample size of cardiac patients with and without heart failure. METHODS AND RESULTS: The EURO-FILLING study is a large, prospective observational study in which simultaneous assessment of invasive and non-invasive measurements of LVFP will be acquired in eight reference European centres. Centralized reading of the collected parameters will be performed in a core laboratory. Not only standardized echo Doppler measurements but also novel echo parameters such as LV global longitudinal strain and global atrial strain (obtainable by two-dimensional speckle tracking echocardiography) will be tested for predicting invasive measurements of LVFP. CONCLUSIONS: The EURO-FILLING study is expected to provide important information on non-invasive assessment of LVFP and to contribute to the standardization of this assessment in clinical practice. [less ▲]Detailed reference viewed: 8 (2 ULg) Effect of misalignment on pull-off test results: numerical and experimental assessmentsCourard, Luc ; Bissonnette, Benoît; Garbacz, Andrzej et alin ACI Materials Journal (2014), 111(2), 153-162The successful application of a concrete repair system is often evaluated through pull-off testing. For such in-situ quality control (QC) testing, the inherent risk of misalignment might affect the ... [more ▼]The successful application of a concrete repair system is often evaluated through pull-off testing. For such in-situ quality control (QC) testing, the inherent risk of misalignment might affect the recorded value and eventually make a difference in the acceptance of the work. So far, the issue of eccentricity in pull-off testing has been ignored in field practice, because it is seen as an academic issue. This paper presents the results of a project intended to quantify the effect of misalignment on pull-off tensile strength evaluation and provide a basis for improving QC specifications if necessary. The test program consisted first in an analytical evaluation of the problem through 2-D FEM simulations and, in a second phase, in laboratory experiments in which the test variables were the misalignment angle (0°, 2° and 4°) and the coring depth (15 mm [1.18 in.], 30 mm [2.36 in.]). It was found that calculations provide a conservative but realistic lower bound limit for evaluation the influence of misalignment upon pull-off test results: a 2° misalignment can be expect to yield a pull-off strength reduction of 7 to 9 % respectively for 15-mm [1.18-in.] and 30-mm [2.36-in.] coring depths, and the corresponding decrease resulting from a 4° misalignment reach between 13 and 16%; From a practical standpoint, the results generated in this study indicate that when specifying a pull-off strength limit in the field, the value should be increased (probable order of magnitude: 15%) to take into account the potential reduction due to testing misalignment. [less ▲]Detailed reference viewed: 15 (2 ULg) Determinants of exercise-induced pulmonary arterial hypertension in systemic sclerosis.Voilliot, Damien; Magne, Julien ; Dulgheru, Raluca et alin International journal of cardiology (2014)BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the ... [more ▼]BACKGROUND: Exercise-induced pulmonary arterial hypertension (EIPH) in systemic sclerosis (SSc) has already been observed but its determinants remain unclear. The aim of this study was to determine the incidence and the determinants of EIPH in SSc. METHODS AND RESULTS: We prospectively enrolled 63 patients with SSc (age 54+/-3years, 76% female) followed in CHU Sart-Tilman in Liege. All patients underwent graded semi-supine exercise echocardiography. Systolic pulmonary arterial pressure (sPAP) was derived from the peak velocity of the tricuspid regurgitation jet and adding the estimation of right atrial pressure, both at rest and during exercise. Resting pulmonary arterial hypertension (PH) was defined as sPAP >35mmHg and EIPH as sPAP >50mmHg during exercise. The following formulas were used: mean PAP (mPAP)=0.61xsPAP+2, left atrial pressure (LAP)=1.9+1.24xleft ventricular (LV) E/e' and pulmonary vascular resistance (PVR)=(mPAP-LAP)/LV cardiac output (CO) and slope of mPAP-LVCO relationship=changes in mPAP/changes in LVCO. Resting PH was present in 3 patients (7%) and 21 patients developed EIPH (47%). Patients with EIPH had higher resting LAP (10.3+/-2.2 versus 8.8+/-2.3mmHg; p=0.03), resting PVR (2.6+/-0.8 vs. 1.4+/-1.1Woods units; p=0.004), exercise LAP (13.3+/-2.3 vs. 9+/-1.7mmHg; p<0.0001), exercise PVR (3.6+/-0.7 vs. 2.1+/-0.9 Woods units; p=0.02) and slope of mPAP-LVCO (5.8+/-2.4 vs. 2.9+/-2.1mmHg/L/min; p<0.0001). After adjustment for age and gender, exercise LAP (beta=3.1+/-0.8; p=0.001) and exercise PVR (beta=7.9+/-1.7; p=0.0001) were independent determinants of exercise sPAP. CONCLUSION: EIPH is frequent in SSc patients and is mainly related to both increased exercise LV filling pressure and exercise PVR. [less ▲]Detailed reference viewed: 10 (0 ULg) High-energy X-ray tomography analysis of a metal packing biofilm reactor for the production of lipopeptides by Bacillus subtilisZune, Quentin ; Soyeurt, Delphine; Toye, Dominique et alin Journal of Chemical Technology & Biotechnology (2014), 89BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the ... [more ▼]BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the production of high-value metabolites. Technically, this new concept relies on the design of bioreactors able to promote biofilm formation and on the identification of the key physico-chemical parameters involved in biofilm formation. RESULTS: An experimental setting comprising a liquid continuously recirculated on a metal structured packing has been used to promote Bacillus subtilis GA1 biofilm formation. The colonization of the packing has been visualized non-invasively by X-ray tomography. This analysis revealed an uneven, conical, distribution of the biofilm inside the packing. Compared with a submerged culture carried out in a stirred tank reactor, significant modification of the lipopeptide profile has been observed in the biofilm reactorwith the disappearance of fengycin and iturin fractions and an increase of the surfactin fraction. In addition, considering the biofilm reactor design, no foam formation has been observed during the culture. CONCLUSIONS: The configuration of this biofilm reactor set-up allows for a higher surfactin production by comparison with a submerged culture while avoiding foam formation. Additionally, scale-up could easily be performed by increasing the number of packing elements. [less ▲]Detailed reference viewed: 50 (28 ULg) On the policy implications of changing longevityPestieau, Pierre ; Ponthiere, Grégory in CESifo Ecoonmic Studies (2014), 60Detailed reference viewed: 11 (1 ULg) The effect of size, weight, body compartment, sex and reproductive status on the bioaccumulation of 19 trace elements in rope-grown Mytilus galloprovincialisRichir, Jonathan ; Gobert, Sylvie in Ecological Indicators (2014), 36Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the ... [more ▼]Numerous trace elements (TEs) can be considered as potential pollutants of the environment, their mining productions and industrial uses increasing worldwide. Their monitoring can be achieved through the use of bioindicator species, such as the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1819). That species has been widely used to monitor the chemical pollution of coastal ecosystems by Cr, Ni, Cu, Zn, Cd, Pb, As, Ag and V. Conversely, environmental levels of Be, Al, Fe, Mn, Co, Se, Mo, Sn, Sb and Bi have been little or not monitored so far in mussel watch programs. Bioaccumulation processes of these 19 TEs in rope-grown M. galloprovincialis purchased from a salt pond with good chemical water quality were thus investigated in the present study. Mussels efficiently accumulated the 19 studied TEs. Bioaccumulation processes were driven by numerous mutually dependent biological parameters such as the mussel size and flesh weight, the sex and the reproductive status and the body compartment considered. TE bioaccumulation was a power function of the mussel soft body dry weight; total contents linearly increased with the shell length. Small-size mussels overall concentrated more TEs, with a high inter-individual variability, consequently influencing the modelling of their bioaccumulation in the whole rope population. Although a large range of rope-grown M. galloprovincialis sizes can be used for monitoring purposes, one will thus take care not to use extreme size individuals. The influence of gametogenesis in determining female body higher TE concentrations prior to spawning could not be neglected and varied depending on the element. TEs were preferentially accumulated in the hepatopancreas, except for Zn, Se, Cd and Mo, more concentrated in gills. Gametogenesis did not influence TE distribution between body compartments, but likely diluted their concentrations as a direct consequence of massive reproductive tissue production. So, results from the present study underline the potential use of M. galloprovincialis in the biomonitoring of numerous little studied TEs and give some insights into the decisive role played by some relevant biological parameters in bioaccumulation processes of the 19 investigated TEs in rope-grown mussels. [less ▲]Detailed reference viewed: 73 (26 ULg) The self-report Version of the LSAS-CA: Psychometric Properties of the French Version in a non-clinical adolescent sampleSchmits, Emilie ; Heeren, Alexandre; Quertemont, Etienne in Psychologica Belgica (2014), 54(2), 181-198The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The ... [more ▼]The Liebowitz Social Anxiety Scale (LSAS) is one of the most popular measures of social anxiety in adults. The LSAS has been adapted for clinical assessment of children and adolescents (LSAS-CA). The psychometric properties of the self-report version of the LSAS-CA (LSAS-CA-SR) have been investigated in a Spanish population. However, no study to date has adapted and validated this scale in French. The purpose of this study was to develop a French version of the LSAS-CA-SR and to assess its score reliability and structural validity in a French-speaking community sample. The sample was made up of 1,343 teenagers from secondary schools, aged between 14 and 18 years. Confirmatory factor analyses established the structural validity of the French version of the LSAS-CA-SR and good psychometric properties, including reliable internal consistency, were observed. [less ▲]Detailed reference viewed: 35 (3 ULg) Hearing capacities and otolith size in two ophidiiform species (Ophidion rochei and Carapus acus)Kever, Loïc ; Colleye, Orphal ; Herrel, Anthony et alin Journal of Experimental Biology (2014), 217Detailed reference viewed: 14 (2 ULg) The role of the youth in community forestry in GabonBoldrini, Sylvie; Meunier, Quentin; Gillet, Pauline et alin Nature et Faune (2014), 28(1), 56-59In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus ... [more ▼]In the wake of the creation of the first community forests in Gabon, the village associations in charge of these forests are handicapped by their own working capacity. Affected by rural exodus, communities however rarely integrate the youth (between the ages of 16 to 24) who reside permanently in the village in village associations. The youth are generally excluded from the decision making process of elders. In fact, the youth that reside permanently in the village do not generally hold any diploma and have no professional qualification. Consequently, they are hardly respected by the people around them and their opinions are not taken into account. They are left out of any activity conducted by the associations unless these activities are remunerated. However, the involvement of the youth in village associations is necessary, not only to increase the work capacity, but also to ensure the perpetuation of interventions since the youth will be the first and future beneficiaries of the community forest. [less ▲]Detailed reference viewed: 70 (20 ULg) Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesisHeusschen, Roy ; Schulkens, Iris; van Beijnum, Judy et alin Biochimica et Biophysica Acta - Molecular Basis of Disease (2014)Detailed reference viewed: 12 (1 ULg) Book Review: Handbook of research methods on social entrepreneurshipDufays, Frédéric in International Small Business Journal (2014), 32(4), 471-475Detailed reference viewed: 35 (0 ULg) A modeling approach to determine the importance of dynamic regulation of plant hydraulic conductivities on the water uptake dynamics in the soil-plant-atmosphere systemLobet, Guillaume ; Pagès, Loïc; Draye, Xavierin Ecological Modelling (2014), (0), 1-11Detailed reference viewed: 14 (4 ULg) Procedural learning across modalities in French-speaking children with specific language impairmentGabriel, Audrey ; Meulemans, Thierry ; Parisse, Christophe et alin Applied Psycholinguistics (2014)It has been suggested that the language problems encountered in specific language impairment (SLI) arise from basal ganglia abnormalities that lead to impaired procedural memory. However, recent serial ... [more ▼]It has been suggested that the language problems encountered in specific language impairment (SLI) arise from basal ganglia abnormalities that lead to impaired procedural memory. However, recent serial reaction time (SRT) studies did not reveal any differences between the SLI and typically developing (TD) groups on the measures of procedural memory linked to visual sequence learning. In this paper, 16 children with and without SLI were compared on two versions of SRT tasks: a visual task and an auditory one. The results showed that children with SLI were as fast as their TD peers in both modalities. All of the children obtained similar specific sequence learning indices, indicating that they were able to detect regularities in both modalities. Although children with SLI were as accurate as their TD peers for the visual SRT task, they made more errors than their TD peers in auditory SRT conditions. The results indicate that, in relation to procedural memory, the core of the impairment in SLI is not linked to difficulties in the detection of regularities. We argue that when children with SLI present some difficulties, the children’s weaknesses might depend on the type of processing involved (e.g., tasks involving auditory sequences). [less ▲]Detailed reference viewed: 146 (35 ULg) Lignin extraction from Mediterranean agro-wastes: Impact of pretreatment conditions on lignin chemical structure and thermal degradation behaviorManara, Panagiota; Zabaniotou, Anastasia; Vanderghem, Caroline et alin Catalysis Today (2014), 223Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical ... [more ▼]Three different types of Mediterranean, agro-industrial wastes (olive kernels, grape pomace/seeds, peach kernels), were subjected to two pretreatment processes, a chemical/organosolv and a physicochemical one. The organosolv process included lignocellulosic biomass treatment with formic acid/acetic acid/water (30/50/20, v/v%), for 3 h at 107 °C, while the physicochemical method was conducted by immersing the biomass in a water/ethanol (8/92, v/v%), H2SO4 0.32 M, solvent and further exposing the slurry to microwave irradiation (maximum 250 W) for 1/2 h at 150 °C. Both processes were evaluated regarding the achieved delignification and the purity of the extracted lignins. The effect of the pretreatment processes onto the structure and thermal decomposition behavior of the extracted lignins was investigated via FT-IR and TGA analysis, respectively. The objective of the research work was to investigate potential valorization routes for these biomass agro-residues in the context of a biorefinery, focusing on lignin extraction. The pretreatment results showed that the obtained lignins, derived from both procedures, were of high purity (>82 wt%). Under the organosolv procedure, peach kernel delignification showed the maximum value (∼16 wt%), while under microwave pretreatment, olive kernel delignification showed the maximum value (∼35 wt%). Grape pomace/seeds appeared to be the most resistant in both treatments. [less ▲]Detailed reference viewed: 31 (13 ULg) EditorialBourgeois, Marc in Revue de Fiscalité Régionale et Locale (2014), Liv. 1Detailed reference viewed: 9 (1 ULg) Peripheral T-cell lymphoma with t(6;14)(p25;q11.2) translocation presenting with massive splenomegaly.SOMJA, Joan ; Bisig, B.; de Leval, L. et alin Virchows Archiv : An International Journal of Pathology (2014)Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14 ... [more ▼]Recurrent chromosomal translocations associated to peripheral T-cell lymphomas (PTCL) are rare. Here, we report a case of PTCL, not otherwise specified (NOS) with the karyotype 46,Y,add(X)(p22),t(6;14)(p25;q11) and FISH-proved breakpoints in the IRF4 and TCRAD loci, leading to juxtaposition of both genes. A 64-year-old male patient presented with mild cytopenias and massive splenomegaly. Splenectomy showed diffuse red pulp involvement by a pleomorphic medium- to large-cell T-cell lymphoma with a CD2+ CD3+ CD5− CD7− CD4+ CD8+/− CD30− TCRbeta-F1+ immunophenotype, an activated cytotoxic profile, and strong MUM1 expression. The clinical course was marked by disease progression in the bone marrow under treatment and death at 4 months. In contrast with two t(6;14)(p25;q11.2)-positive lymphomas previously reported to be cytotoxic PTCL, NOS with bone marrow and skin involvement, this case was manifested by massive splenomegaly, expanding the clinical spectrum of PTCLs harboring t(6;14)(p25;q11.2) and supporting consideration of this translocation as a marker of biological aggressiveness. [less ▲]Detailed reference viewed: 10 (0 ULg) Ligand and solvation effects on the structural and electronic properties of small gold clustersDufour, F.; Fresch, Barbara ; Durupthy, O. et alin Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2014), 118(8), 4362Detailed reference viewed: 11 (2 ULg) First-principles study of the lattice dynamical properties of strontium ruthenateMiao, Naihua ; Bristowe, Nicholas ; Xu, Bin et alin Journal of Physics : Condensed Matter (2014), 26By means of first-principles calculations, various properties of SrRuO3 are investigated, focusing on its lattice dynamical properties. Despite having a Goldschmidt tolerance factor very close to 1, the ... [more ▼]By means of first-principles calculations, various properties of SrRuO3 are investigated, focusing on its lattice dynamical properties. Despite having a Goldschmidt tolerance factor very close to 1, the phonon dispersion curves of the high-temperature cubic phase of SrRuO3 show strong antiferrodistortive instabilities. The energetics of metastable phases with different tilt patterns are discussed, concluding that the coupling of oxygen rotation modes with anti-polar Sr motion plays a key role in stabilizing the Pnma phase with respect to alternative rotation patterns. Our systematic analysis confirms previous expectations and contributes to rationalizing better why many ABO3 perovskites, including metallic compounds, exhibit an orthorhombic ground state. The zone-center phonon modes of the Pnma phase have been computed, from which we propose partial reassignment of available experimental data. The full dispersion curves have also been obtained, constituting benchmark results for the interpretation of future measurements and providing access to thermodynamical properties. [less ▲]Detailed reference viewed: 42 (15 ULg) Ciseau tarifaire : La Commission européenne jouit d’une large marge de discrétion lorsqu’elle prend en considération les décisions et documents établis par les régulateurs sectoriels nationauxSibony, Anne-Lise ; Demoulin, Iris in Concurrences : Revue des Droits de la Concurrence (2014), N° 1-2014Detailed reference viewed: 25 (2 ULg) La lumière comme stimulant de l’activité cognitive cérébraleVandewalle, Gilles in Medecine Sciences : M/S (2014), In pressDetailed reference viewed: 5 (0 ULg) Vol vaderlands leven en volksgezind streven: Het Kinkergenootschap te Luik (1886-ca. 1913)Steyaert, Kris in Negentiende Eeuw (2014), 38(1), 41-60The Kinker Association was founded in 1886 for the benefit of the many Dutch-speaking Flemings living and working in francophone Liège. Organizing lectures on a variety of subjects, the Association ... [more ▼]The Kinker Association was founded in 1886 for the benefit of the many Dutch-speaking Flemings living and working in francophone Liège. Organizing lectures on a variety of subjects, the Association attempted to exert an emancipatory influence. Not only did it set up an extensive Dutch library but it also provided access to medical care and insurance. Above all, the Kinker Association wanted to boost the presence of Dutch-related cultural activities in the city. With its liberal sympathies and close links to the Willems Fonds, the Association met with opposition from various quarters, not least from the Catholic Church. This article looks in detail at the genesis, and rise and fall of the Association, its membership and its place and appeal within the wider socio-cultural context of late-nineteenth-century Wallonia. [less ▲]Detailed reference viewed: 22 (1 ULg) Low temperature crystallization of yttrium orthoferrite by organic acid-assisted sol-gel synthesisStevens, Frédéric ; Cloots, Rudi ; Poelman, D. et alin Materials Letters (2014), 114Yttrium orthoferrite (YFeO3) is a promising material for visible light photocatalytic applications due to its band gap of 2.2-2.6 eV. However, during the synthesis of YFeO3, unwanted composition can be ... [more ▼]Yttrium orthoferrite (YFeO3) is a promising material for visible light photocatalytic applications due to its band gap of 2.2-2.6 eV. However, during the synthesis of YFeO3, unwanted composition can be obtained and the crystallization requires temperatures as high as 850 C. Powders of YFeO3 were prepared using a sol-gel method with and without organic acids (citric acid, tartaric acid, malonic acid and oxalic acid) used as organic modifiers. The band gap of these powders was measured by diffuse reflection spectroscopy, and the crystallinity and crystalline phase content were characterized by X-ray diffraction. Organic acids allow a higher purity and facilitate crystallization. This work aims to produce YFeO3 powders at the lowest possible temperature. Citric acid was found to be the best additive: it reduces the crystallization temperature below 450 C. This opens new perspectives such as the deposition of crystalline YFeO3 thin films onto conductive glass for water-splitting applications. © 2013 Elsevier B.V. [less ▲]Detailed reference viewed: 39 (10 ULg) Popular Economy in Santiago de Chile: State of Affairs and ChallengesBauwens, Thomas ; Lemaître, Andreiain World Development : The Multi-Disciplinary International Journal Devoted to the Study and Promotion of World Development (2014), 64Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile ... [more ▼]Do informal initiatives share a capitalist spirit of entrepreneurship? This article attempts to answer this question, using a “popular economy” analytical framework and focusing on the case of Chile. First, we present the context of the research, namely the economic and political evolutions in Chile since the 1970s and their effects on the popular economy. Then, we seek to answer the original question, relying on in-depth case studies of so-called “popular economy organizations”. Our research shows that their socio-economic logics significantly differ from those of the traditional capitalist firm. Our observations also suggest important differences between current and older initiatives. [less ▲]Detailed reference viewed: 21 (0 ULg) Les élèves de 15 ans face aux ordinateurs en Fédération Wallonie-Bruxelles. Résultats de PISA 2012 aux épreuves de résolution de problèmes, de lecture et de mathématiques administrées sur ordinateur, attitudes et comportements par rapport aux TICsBlondin, Christiane ; Crepin, Françoise ; Demonty, Isabelle et alin Cahiers des Sciences de l'Education (Les) (2014), 35Detailed reference viewed: 15 (0 ULg) Faible probabilité de démontrer l’existence d’une violation de l’article 102 TFUE : La Cour de justice de l’Union européenne juge que la Commission européenne peut refuser d’instruire une plainte uniquement en raison de la faible probabilité d’établir une infraction, indépendamment de sa gravitéSibony, Anne-Lise ; Demoulin, Iris in Concurrences : Revue des Droits de la Concurrence (2014)Detailed reference viewed: 26 (3 ULg) Reprint of: Policy decisions on endocrine disruptors should be based on science across disciplines: A response to Dietrich, et al.Gore, A. C.; Balthazart, Jacques ; Bikle, D. et alin Frontiers in neuroendocrinology (2014), 35(1), 2-5Detailed reference viewed: 5 (1 ULg) Chemical and biological evaluation of the nutritive value of Algerian green seaweed Ulva lactuca using in vitro gas production technique fior ruminant animalsZitouni, Hind; Arhab, Rabah; Boudry, Christelle et alin International Journal of Advanced Research (2014), 2(4), 916-925This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to ... [more ▼]This study aimed to determine the nutritive value of seaweed Ulva lactuca collected from the Algerian coast by estimation of its chemical composition and fermentation characteristics, comparatively to vetch-oat hay (control), using in vitro gas production technique. Seaweed and control were incubated with rumen liquor taken from fistulated and non lactating cows. Gas production was recorded at: 2, 4, 6, 8, 12, 24, 48 and 72h. The in vitro rumen fermentation parameters were measured after 24h and 72h of fermentation. Proteins degradability was investigated by the enzymatic technique using a protease extracted from Streptomyces griseus. The results showed a wide variation between the chemical components of seaweed and conventional fodder used as control. The main constituents in Ulva lactuca were ashes (39.1% DM), fibers (22.8 % DM) and proteins (15.3% DM). The gas production profile of seaweed during 72h of incubation showed a slow and low gas production. Cumulative gas production obtained after 24h for seaweed (42 ml/g OM) was significantly lower than control (128.4 ml/g OM) (P<0.001). pH, ammonia, volatile fatty acids (VFAs), apparent digestibility of dry matter (DDM), organic matter digestibility (OMD) and metabolizable energy (ME) were significantly different between seaweed and vetch-oat hay (6.86, 290.1 mg/ml, 1.25 mmol/g DM, 38.3%, 29.2%, 3.81MJ/Kg DM respectively for seaweed). Protein degradability measurement indicates the weak hydrolysis of seaweed crude protein which is beneficial for ruminants. This study showed that the use of Ulva lactuca as non conventional feed in ruminant nutrition can be considered under certain conditions. [less ▲]Detailed reference viewed: 30 (1 ULg) Functionalization of carbon xerogels for the preparation of palladium supported catalysts applied in sugar transformationsMager, Nathalie; Meyer, Nathalie; Léonard, Alexandre et alin Applied Catalysis B : Environmental (2014), 148-149Detailed reference viewed: 41 (5 ULg) Characterization of multi-walled carbon nanotube dispersion in resorcinol-formaldehyde aerogelHaghgoo, Majid; Yousefi, Ali Akbar; Zohouriaan Mehr, Mohammad Jalal et alin Microporous and Mesoporous Materials (2014), 184Detailed reference viewed: 15 (1 ULg) Interactions of subunits Asa2, Asa4 and Asa7 in the peripheral stalk of the mitochondrial ATP synthase of the chlorophycean alga Polytomella sp.Miranda-Astudillo, Hector; Cano-Estrada, Araceli; Vazquez-Acevedo, Miriam et alin Biochimica et Biophysica Acta-Bioenergetics (2014), 1837Detailed reference viewed: 18 (4 ULg) Head Trauma and Distal Anterior Cerebral Artery Aneurysm: Potential Role of an Adhesion to the FalxScholtes, Félix ; HENROTEAUX, Adrienne ; OTTO, Bernard et alin Journal of Neurological Surgery. Part A, Central European Neurosurgery (2014), [Epub ahead of print]Detailed reference viewed: 28 (11 ULg) Compte rendu de l'ouvrage de J.R. Brandt, J.W. Iddeng (éds), Greek and Roman Festivals: Content, Meaning, and PracticePaul, Stéphanie in Revue Archeologique (2014), 57(1), 174-175Detailed reference viewed: 8 (0 ULg) Deciphering human-climate interactions in an ombrotrophic peat record: REE, Nd and Pb isotope signatures of dust supplies over the last 2500 years (Misten bog, Belgium)Fagel, Nathalie ; Allan, M.; Le Roux, G. et alin Geochimica et Cosmochimica Acta (2014), 123Detailed reference viewed: 33 (5 ULg) Cuando la Historia se hace historia: (re)creación de Pancho Villa por Nellie Campobello en los Apuntes sobre la vida militar de Francisco Villa (1940)François, Jéromine in Anales de Literatura Hispanoamericana (2014), 43Detailed reference viewed: 28 (4 ULg) Thinking out of the box - New approaches to controlling GVHDBaron, Frédéric ; Humblet-Baron, Stéphanie; Ehx, Grégory et alin Current Hematologic Malignancy Reports (2014), 9Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD ... [more ▼]Graft-versus-host disease (GVHD) remains a major limitation of allogeneic hematopoietic cell transplantation (allo-HCT). Despite major advances in the understanding of GVHD pathogenesis, standard GVHD prophylaxis regimens continue to bebased on the combination of a calcineurin inhibitor with an antimetabolite, while first line treatmentsstill relies on high-dose corticosteroids. Further, no second line treatment has emerged thus far in acute or chronic GVHD patients who failed on corticosteroids. After briefly reviewing current standards of GVHD prevention and treatment, this article will discuss recent approaches that might change GVHD prophylaxis / treatment in the next decades, with a special focus on recently developed immunoregulatory strategies based on infusion of mesenchymal stromal or regulatory T-cells, or on injection of lowdose interleukin-2. [less ▲]Detailed reference viewed: 31 (10 ULg) Aider à vivre, aider à mourirJamoulle, Marc in Pratiques : les Cahiers de la Médecine Utopique (2014), 66Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts ... [more ▼]Aider à vivre et aider à mourir ne sont pas tellement éloignés l’un de l’autre en médecine de famille. Au quotidien, la différence est tranchée et la limite claire. Il y a les vivants et il y a les morts. Pas si sûr. Entre vie et mort, le fil est parfois ténu. [less ▲]Detailed reference viewed: 6 (1 ULg) Effect of N-acetylcysteine combined with infliximab on toxic epidermal necrolysis. A proof-of-concept study.PAQUET, Philippe ; JENNES, Serge; ROUSSEAU, Anne-Françoise et alin Burns : Journal of the International Society for Burn Injuries (2014)Detailed reference viewed: 16 (2 ULg) Amantadine, Apomorphine and Zolpidem in the Treatment of Disorders of ConsciousnessGosseries, Olivia ; Charland-Verville, Vanessa ; Thonnard, Marie et alin Current Pharmaceutical Design (2014), 20Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a minimally conscious state. Pharmacological treatments of patients with disorders of consciousness aim to ... [more ▼]Survivors of severe brain injuries may end up in a state of 'wakeful unresponsiveness' or in a minimally conscious state. Pharmacological treatments of patients with disorders of consciousness aim to improve arousal levels and recovery of consciousness. We here provide a systematic overview of the therapeutic effects of amantadine, apomorphine and zolpidem in patients recovering from coma. Evidence from clinical trials using these commonly prescribed pharmacological agents suggests positive changes in the neurological status in patients, leading sometimes to dramatic improvements. These findings are discussed in the context of current hypotheses of these agents' therapeutic mechanisms on cerebral function. In order to enhance our understanding of the underlying pathophysiological mechanisms of these drugs, we suggest combining sensitive and specific behavioral tools with neuroimaging and electrophysiological measures in large randomized, double-blind, placebo-controlled experimental designs. We conclude that the pharmacokinetics and pharmacodynamics of amantadine, apomorphine and zolpidem need further exploration to determine which treatment would provide a better neurological outcome regarding the patient's etiology, diagnosis, time since injury and overall condition. [less ▲]Detailed reference viewed: 144 (11 ULg) In Vitro and In Vivo Antiplasmodial Activity of Three Rwandan Medicinal Plants and Identification of Their Active CompoundsMuganga, Raymond; Angenot, Luc ; Tits, Monique et alin Planta Medica (2014), 80(6), 482-489In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to ... [more ▼]In our previous study, we reported the interesting in vitro antiplasmodial activity of some Rwandan plant extracts. This gave rise to the need for these extracts to also be evaluated in vivo and to identify the compounds responsible for their antiplasmodial activity. The aim of our study was, on the one hand, to evaluate the antiplasmodial activity in vivo and the safety of the selected Rwandan medicinal plants used in the treatment of malaria, with the objective of promoting the development of improved traditional medicines and, on the other hand, to identify the active ingredients in the plants. Plant extracts were selected according to their selectivity index. The in vivo antiplasmodial activity of aqueous, methanolic, and dichloromethane extracts was then evaluated using the classical 4-day suppressive test on Plasmodium berghei infected mice. The activity of the plant extracts was estimated by measuring the percentage of parasitemia reduction, and the survival of the experimental animals was recorded. A bioguided fractionation was performed for the most promising plants, in terms of antiplasmodial activity, in order to isolate active compounds identified by means of spectroscopic and spectrometric methods. The highest level of antiplasmodial activity was observed with the methanolic extract of Fuerstia africana (> 70 %) on days 4 and 7 post-treatment after intraperitoneal injection and on day 7 using oral administration. After oral administration, the level of parasitemia reduction observed on day 4 post-infection was 44 % and 37 % with the aqueous extract of Terminalia mollis and Zanthoxylum chalybeum, respectively. However, the Z. chalybeum extract presented a high level of toxicity after intraperitoneal injection, with no animals surviving on day 1 post-treatment. F. africana, on the other hand, was safer with 40 % mouse survival on day 20 post-treatment. Ferruginol is already known as the active ingredient in F. Africana, and ellagic acid (IC50 = 175 ng/mL) and nitidine (IC50 = 77.5 ng/mL) were identified as the main active constituents of T. mollis and Z. chalybeum, respectively. F. africana presented very promising antiplasmodial activity in vivo. Although most of the plants tested showed some level of antiplasmodial activity, some of these plants may be toxic. This study revealed for the first time the role of ellagic acid and nitidine as the main antimalarial compounds in T. mollis and Z. chalybeum, respectively. [less ▲]Detailed reference viewed: 15 (1 ULg) The peasants in turmoil: Khmer Rouge, state formation and the control of land in northwest CambodiaDiepart, Jean-Christophe ; Dupuis, Davidin The Journal of Peasant Studies (2014), 41(4), 445468Over the past 15 years, northwest Cambodia has seen dramatic agrarian expansion away from the central rice plain into the peripheral uplands fuelled by peasant in-migration. Against this background, we ... [more ▼]Over the past 15 years, northwest Cambodia has seen dramatic agrarian expansion away from the central rice plain into the peripheral uplands fuelled by peasant in-migration. Against this background, we examine the nature of relations between the peasantry and the state. We first show the historical continuities of land control processes and how the use of violence in a post-conflict neoliberal context has legitimised ex-Khmer Rouge in controlling land distribution. Three case studies show the heterogeneity of local level sovereignties, which engage the peasants in different relations with authority. We examine how these processes result in the construction of different rural territories along the agricultural frontier and argue that, in this region of Cambodia, the struggles between Khmer Rouge and neoliberal modes of land control are central to state formation processes. [less ▲]Detailed reference viewed: 13 (1 ULg) Robot-assisted laparoscopy for deep infiltrating endometriosis: international multicentric retrospective study.Collinet, Pierre; Leguevaque, Pierre; Neme, Rosa Maria et alin Surgical Endoscopy (2014), sous presseBACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April ... [more ▼]BACKGROUND: This study aimed to assess the interest in robot-assisted laparoscopy for deep infiltrating endometriosis and to investigate the perioperative results. METHODS: From November 2008 to April 2012, 164 women with stage 4 endometriosis who underwent robot-assisted laparoscopy (da Vinci Intuitive Surgical System) were included by to eight international participating clinical centers. This study evaluated the procedures performed, the duration of the intervention, the complications, the recurrence, and the impact on fertility. RESULTS: The average operative time was 180 min. The main complications were laparotomy (n = 1, 0.6 %), sutured bowel injury (n = 2, 1.2 %), transfusion for a 2,300-ml bleed (n = 1), prolonged urinary catheterization (n = 1, 0.6 %), ureter-bladder anastomotic leak (n = 1, 0.6 %), and ureteral fistula after ureterolysis (n = 2, 1.2 %). The reoperation rate was 1.8 % (n = 3). The mean follow-up period was 10.2 months. A full recovery was experienced by 86.7 % (98/113) of the patients. After surgery, 41.2 % (42/102) of the patients had a desire for pregnancy, and 28.2 % (11/39) of them became pregnant. CONCLUSION: This study analyzed the largest series of robot-assisted laparoscopies for deep infiltrating endometriosis published in the literature. No increase in surgical time, blood loss, or intra- or postoperative complications was observed. The interest in robot-assisted laparoscopy for deep infiltrating endometriosis seems to be promising. [less ▲]Detailed reference viewed: 15 (5 ULg) Antioxidant capacity of small dark fruits. Influence of cultivars and harvest timeKevers, Claire ; PINCEMAIL, Joël ; Defraigne, Jean-Olivier et alin Journal of Berry Research (2014)BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits ... [more ▼]BACKGROUND: Small dark fruits represent one of the most important sources of bioactive compounds with antioxidant capacity in the human diet. The content of health-promoting antioxidants in these fruits may be important information to take into account when a fruit producer has to choose which cultivar to grow. OBJECTIVE: It is important to know how antioxidant capacity and antioxidant compounds as total phenolics and ascorbic acid vary between 9 small dark fruit species and for each species among cultivars (2 to 10 per species). METHODS: The antioxidant capacity (ORAC assay), total phenolic (Folin-Ciocalteu) and ascorbic acid content were measured in 9 fruits (plums, blackcurrants, blackberries, blueberries, cherries, redcurrants, raspberries, white currants and gooseberries) / 42 cultivars harvested at maturity during their high production period. RESULTS: The comparison of the average of the various cultivars of each small fruits showed that blackcurrants had the best antioxidant capacity (with plums), the highest ascorbic acid content and the highest total phenolic content (with blackberries). The present study shows that total phenolic compounds, ascorbic acid and antioxidant capacity strongly differed between genotypes of each small dark fruits. Other parameters as harvest time, culture conditions and maturity degree at the harvest may also influence the antioxidant capacity of small fruits. CONCLUSION: Among small dark fruits, blackcurrants have high qualities. Choices of variety, harvest time and maturity degree are important for all fruits. [less ▲]Detailed reference viewed: 78 (18 ULg) Forkhead pathway in the control of adult neurogenesis.Genin, Emmanuelle C.; Caron, Nicolas ; Vandenbosch, Renaud et alin Stem cells (Dayton, Ohio) (2014)Detailed reference viewed: 1 (0 ULg) Les sons de contact de l'ombrine côtière - Umbrina cirrosa (Linné, 1758)Lagardère, Jean-Paul; Parmentier, Eric in Bulletin de la Société de Borda (2014), 514Detailed reference viewed: 11 (0 ULg) MALDI-TOF MS Analysis of Cellodextrins and Xylo-oligosaccharides Produced by Hindgut Homogenates of Reticulitermes santonensisBrasseur, Catherine ; Bauwens, Julien ; Tarayre, Cédric et alin Molecules (2014), 19Detailed reference viewed: 17 (4 ULg) Dioxins and polychlorinated biphenyls contamination in poultry liver related to food safety - A reviewGhimpeteanu, Oana-Margarita; Militaru, Manuella; Scippo, Marie-Louise in Food Control (2014), 38The present article reviews the most important scientiﬁc literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated ... [more ▼]The present article reviews the most important scientiﬁc literature on dioxins and PCBs found in poultry liver and their relation with food safety and consumers’ health. Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants with high chemical stability; they are lipophilic compounds and they are not destroyed by microbial, photochemical, chemical or thermal degradation. Dioxins and PCBs are ubiquitous environmental contaminants, which are present in all marine plant and animals, birds, mammals and humans and bioaccumulate through the food chain. In the last years, there has been concern regarding food contamination with different chemical substances and their effect on food safety. More particularly, at the end of the 20th and the beginning of the 21st century, there were a series of incidents related to dioxin and PCBs, which directly affected human or contaminated the soil and accumulated in feed and then in food products, such as poultry liver. It was shown in case of dioxin incident that tetra and penta-chlorinated congeners (the most toxic ones) accumulates selectively in poultry livers. Maximal concentrations have been ﬁxed in the European legislation for dioxins and PCBs in food from animal origin, in order to protect the consumer. Data about background poultry liver contamination are scarce and the few available show levels below the legal limit for dioxins, but data are still lacking for DL-PCBs. [less ▲]Detailed reference viewed: 28 (5 ULg) Le dernier maillon de la chaîne des tourbières des hauts-plateaux ardennais : le projet LIFE+ « restauration des habitats naturels de l’Ardenne liégeoise »Plunus, Julie; Parkinson, Denis ; Frankard, Philippe et alin Forêt Wallonne (2014)Detailed reference viewed: 21 (3 ULg) Erratum: SN 2007uy − metamorphosis of an aspheric Type Ib explosionRoy, Rupak in Monthly Notices of the Royal Astronomical Society (2014)The supernovae (SNe) of Type Ibc are rare and the detailed characteristics of these explosions have been studied only for a few events. Unlike Type II SNe, the progenitors of Type Ibc have never been ... [more ▼]The supernovae (SNe) of Type Ibc are rare and the detailed characteristics of these explosions have been studied only for a few events. Unlike Type II SNe, the progenitors of Type Ibc have never been detected in pre-explosion images. So, to understand the nature of their progenitors and the characteristics of the explosions, investigation of proximate events are necessary. Here we present the results of multi-wavelength observations of Type Ib \sn\ in the nearby ($\sim$ 29.7 Mpc) galaxy NGC 2770. Analysis of the photometric observations revealed this explosion as an energetic event with peak absolute $R$ band magnitude $-18.5\pm0.16$, which is about one mag brighter than the mean value ($-17.6\pm0.6$) derived for well observed Type Ibc events. The SN is highly extinguished, \ebv\ = 0.63$\pm$0.15 mag, mainly due to foreground material present in the host galaxy. From optical light curve modeling we determine that about 0.3 \msun\ radioactive $^{56}$Ni is produced and roughly 4.4 \msun\ material is ejected during this explosion with liberated energy $\sim 15\times10^{51}$ erg, indicating the event to be an energetic one. Through optical spectroscopy, we have noticed a clear aspheric evolution of several line forming regions, but no dependency of asymmetry is seen on the distribution of $^{56}$Ni inside the ejecta. The SN shock interaction with the circumburst material (CSM) is clearly noticeable in radio follow-up, presenting a Synchrotron Self Absorption (SSA) dominated light curve with a contribution of Free Free Absorption (FFA) during the early phases. Assuming a Wolf-Rayet (WR) star, with wind velocity $\ga 10^3 {\rm km~s}^{-1}$, as a progenitor, we derive a lower limit to the mass loss rate inferred from the radio data as $\dot{M} \ga 2.4\times10^{-5}$ \msun\,~yr$^{-1}$, which is consistent with the results obtained for other Type Ibc SNe bright at radio frequencies. [less ▲]Detailed reference viewed: 12 (3 ULg) Interdisciplinary approaches to the phenomenology of auditory verbal hallucinationsWoods, A; Jones, N; Bernini, M et alin Schizophrenia Bulletin (2014), 40Detailed reference viewed: 7 (0 ULg) The effects of stress on singing voice accuracyLarrouy, Pauline ; Morsomme, Dominique in Journal of Voice (2014), 28(1), 52-58Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the ... [more ▼]Objective: The quality of a music performance can be lessened or enhanced if the performer experiences stressful conditions. In addition, the quality of a sung performance requires control of the fundamental frequency of the voice, which is particularly sensitive to stress. The present study aimed to clarify the effects of stress on singing voice accuracy. Methods: Thirty-one music students were recorded in a stressful condition (i.e., a music examination) and a non-stressful condition. Two groups were defined according to the challenge level of the music examination (first and second music levels). Measurements were made by self-reported state anxiety (CSAI-2R questionnaire) and by observing heart rate activity (electrocardiogram) during each performance. In addition, the vocal accuracy of the sung performances was objectively analyzed. Results: As expected, state anxiety and heart rate were significantly higher on the day of the music examination than in the non-stressful condition for all the music students. However, the effect of stress was positive for the first-year students but negative for the second-year students, for whom the music examination was particularly challenging. In addition, highly significant correlations were found between the intensity of cognitive symptoms and the vocal accuracy criteria. Discussion: This study highlights the contrasting effects of stress on singing voice accuracy but also the need to consider the challenge level and perception of the symptoms in experimental and pedagogical settings. [less ▲]Detailed reference viewed: 64 (17 ULg) LA RADIOBIOLOGIE POUR LES NÉOPHYTESCOUCKE, Philippe ; MARTINIVE, Philippe in Revue Médicale de Liège (2014), 69(Supp 1), 16-19La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec ... [more ▼]La radiothérapie moderne ne se base pas unique - ment sur l’exploitation des améliorations en informatique, imagerie et robotique. La meilleure distribution de la dose au niveau de la cible, avec l’épargne des tissus sains avoisinants, rend possible une nouvelle exploitation de concept de radio - biologie. L’exemple type est la redécouverte des traitements hypo-fractionnés. [less ▲]Detailed reference viewed: 20 (2 ULg) Subspace-based identification of a nonlinear spacecraft in the time and frequency domainsNoël, Jean-Philippe ; Marchesiello, Stefano; Kerschen, Gaëtan in Mechanical Systems & Signal Processing (2014), 43(1-2), 217-236The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and ... [more ▼]The objective of the present paper is to address the identification of a strongly nonlinear satellite structure. To this end, two nonlinear subspace identification methods formulated in the time and frequency domains are exploited, referred to as the TNSI and FNSI methods, respectively. The modal parameters of the underlying linear structure and the coefficients of the nonlinearities will be estimated by these two approaches based on periodic random measurements. Their respective merits will also be discussed in terms of both accuracy and computational efficiency and the use of stabilisation diagrams in nonlinear system identification will be introduced. The application of interest is the SmallSat spacecraft developed by EADS-Astrium, which possesses an impact-type nonlinear device consisting of eight mechanical stops limiting the motion of an inertia wheel mounted on an elastomeric interface. This application is challenging for several reasons including the non-smooth nature of the nonlinearities, high modal density and high non-proportional damping. [less ▲]Detailed reference viewed: 26 (6 ULg) ÉDITORIAL : Augmenter la visibilité de la radiothérapieCOUCKE, Philippe in Revue Médicale de Liège (2014), 69(Supp 1), 1-2Detailed reference viewed: 24 (3 ULg) Atlantic-Pacific seesaw and its role in outgassing CO2 during Heinrich eventsMenviel, L.; England, M.H.; Meissner, K.J. et alin Paleoceanography (2014), 29Detailed reference viewed: 28 (5 ULg) Quand le savoir s'emmêle... La construction discursive de la norme chez les locuteurs non expertsMeunier, Deborah ; Rosier, Laurencein Carnets du Cediscor (2014), 12Detailed reference viewed: 30 (7 ULg) Special volume of the Journal of Cleaner Production on “Integrating corporate sustainability performance measurement, management control and reporting”Maas, Karen; Crutzen, Nathalie ; Schaltegger, Stefanin Journal of Cleaner Production (2014), 65Detailed reference viewed: 24 (1 ULg) Plant selection for nest building by western lowland gorillas in CameroonWillie, Jacob; Tagg, Nikki; Petre, Charles-Albert et alin Primates : Journal of Primatology (2014)Detailed reference viewed: 22 (13 ULg) Antioxidant capacity of hydrophilic food matrices: optimization and validation of ORAC assay.Kevers, Claire ; Sipel, Arnaud; PINCEMAIL, Joël et alin Food Analytical Methods (2014), 7It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified ... [more ▼]It is widely accepted that ORAC is a useful method for assessing food extracts that contain various antioxidants. The principal aim of this study was to validate the ORAC assay. We first identified parameters that can interfere with the ORAC assay and we optimized it. Then, experiments were conducted to determine the limits of linearity and response function, to determine the accuracy profiles to circumvent some of the drawbacks of traditional validation procedures. Trueness, selectivity and limits of quantification of the method were also determined. Our objective of ORAC method validation is thus to give guarantees that most of the results generated during use of this method will be close enough to unknown true value of antioxidant capacity of food matrices. The validation results indicate that the described method will give accurate and reliable results for Trolox equivalent values ranging from 50 to 200 µmol/L. [less ▲]Detailed reference viewed: 40 (9 ULg) SECOND ORDER SYMMETRIES OF THE CONFORMAL LAPLACIANMichel, Jean-Philippe ; Radoux, Fabian ; Silhan, Josefin Symmetry, Integrability and Geometry: Methods and Applications [=SIGMA] (2014), 10(016), 26Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by ... [more ▼]Let (M,g) be an arbitrary pseudo-Riemannian manifold of dimension at least 3. We determine the form of all the conformal symmetries of the conformal (or Yamabe) Laplacian on (M,g), which are given by differential operators of second order. They are constructed from conformal Killing 2-tensors satisfying a natural and conformally invariant condition. As a consequence, we get also the classification of the second order symmetries of the conformal Laplacian. Our results generalize the ones of Eastwood and Carter, which hold on conformally flat and Einstein manifolds respectively. We illustrate our results on two families of examples in dimension three. [less ▲]Detailed reference viewed: 15 (0 ULg) Reproduction, smell, and neurodevelopmental disorders: genetic defects in different hypogonadotropic hypogonadal syndromes.Valdes-Socin, Hernan; Rubio Almanza, Matilde; Tome Fernandez-Ladreda, Mariana et alin Frontiers in endocrinology (2014), 5The neuroendocrine control of reproduction in mammals is governed by a neural hypothalamic network of nearly 1500 gonadotropin-releasing hormone (GnRH) secreting neurons that modulate the activity of the ... [more ▼]The neuroendocrine control of reproduction in mammals is governed by a neural hypothalamic network of nearly 1500 gonadotropin-releasing hormone (GnRH) secreting neurons that modulate the activity of the reproductive axis across life. Congenital hypogonadotropic hypogonadism (HH) is a clinical syndrome that is characterized by partial or complete pubertal failure. HH may result from inadequate hypothalamic GnRH axis activation, or a failure of pituitary gonadotropin secretion/effects. In man, several genes that participate in olfactory and GnRH neuronal migration are thought to interact during the embryonic life. A growing number of mutations in different genes are responsible for congenital HH. Based on the presence or absence of olfaction dysfunction, HH is divided in two syndromes: HH with olfactory alterations [Kallmann syndrome (KS)] and idiopathic hypogonadotropic hypogonadism (IHH) with normal smell (normosmic IHH). KS is a heterogeneous disorder affecting 1 in 5000 males, with a three to fivefold of males over females. KS is associated with mutations in KAL1, FGFR1/FGF8, FGF17, IL17RD, PROK2/PROKR2, NELF, CHD7, HS6ST1, FLRT3, SPRY4, DUSP6, SEMA3A, NELF, and WDR11 genes that are related to defects in neuronal migration. These reproductive and olfactory deficits include a variable non-reproductive phenotype, including sensorineural deafness, coloboma, bimanual synkinesis, craniofacial abnormalities, and/or renal agenesis. Interestingly, defects in PROKR2, FGFR1, FGF8, CHD7, DUSP6, and WDR11 genes are also associated with normosmic IHH, whereas mutations in KISS1/KISSR, TAC3/TACR3, GNRH1/GNRHR, LEP/LEPR, HESX1, FSHB, and LHB are only present in patients with normosmic IHH. In this paper, we summarize the reproductive, neurodevelopmental, and genetic aspects of HH in human pathology. [less ▲]Detailed reference viewed: 10 (0 ULg) External constraints on optical control strategies in molecular orientation and photofragmentation: role of zero-area fieldsSugny, Dominique; Vranckx, Stéphane; Ndong, Mamadou et alin Journal of Modern Optics (2014), 61Detailed reference viewed: 9 (0 ULg) Comparative evaluation of existing and new methods for correcting ocular artifacts in electroencephalographic recordingsKirkove, Murielle ; François, Clémentine ; Verly, Jacques in Signal Processing (2014), 98(C), 102-120EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable ... [more ▼]EEG signals are often contaminated by ocular artifacts (OAs), in particular when they are recorded for a subject that is, in principle, awake, such as in a study of drowsiness. It is generally desirable to detect and/or correct these OAs before interpreting the EEG signals. We have identified 11 existing methods for dealing with OAs. Their study allowed us to create 16 new methods. We performed a comparative performance evaluation of the resulting 27 distinct methods using a common set of data and a common set of metrics. The data was recorded during a driving task of about two hours in a driving simulator. This led to a ranking of all methods, with five emerging clear winners, comprising two existing methods and three new ones. [less ▲]Detailed reference viewed: 28 (10 ULg) Léopold Auguste Warnkönig et François Laurent Pionniers des Universités de Liège et GandGerkens, Jean-François in Revue de la Faculté de Droit de l'Université de Liège (2014), (1), 157-171Detailed reference viewed: 3 (0 ULg) Land rights as an engine of growth ? An analysis of Cambodian landgrabs in the context of development theoryRudi, Lisa-Marie; Azadi, Hossein; Witlox, Frank et alin Land Use Policy (2014), (38), 564-572Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian ... [more ▼]Forceful evictions have become a serious problem in Cambodia with an increasing number of fami-lies being deprived of their land, homes and livelihoods without compensation. This article analysesCambodian land rights in the context of economic development theory. It assesses whether increas-ing economic inequalities, stemming from forceful evictions, can be categorized as an impediment toCambodian economic growth. The Cambodian case illustrates that a lack of good governance due tocorruption leads to the unequal distribution of land which, in turn, causes inequitable economic devel-opment. The paper concludes that Cambodia is trapped in a vicious cycle of inequality, which is upheld byelites who benefit from evictions and land concessions while evictees become trapped in poverty. Giventhat the population is growing angrier, the article warns of potential for a violent revolution that couldhave disastrous consequences for the Cambodian kingdom, a country that recently emerged from yearsof civil conflicts and is still in the process of rebuilding its social fabric. [less ▲]Detailed reference viewed: 28 (6 ULg) Optimization of a formic/acetic acid delignification treatment on beech wood and its influence on the structural characteristics of the extracted ligninsSimon, Mathilde; Brostaux, Yves ; Vanderghem, Caroline et alin Journal of Chemical Technology & Biotechnology (2014), 89(1), 128-136Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for ... [more ▼]Background In order to replace petrochemicals by bio-based lignin products in a lot of high value-added applications, a formic/acetic acid treatment was adapted to beech wood (Fagus sylvatica L.) for lignin extraction. Results Beech wood particles were delignified at atmospheric pressure by a formic acid/acetic acid/water mixture. Cooking time and temperature were optimized for delignification, pulp yield and 2-furfural concentration. Response surface design analysis revealed that delignification yield increased with cooking time and temperature. Conclusion The multi-criteria optimization of delignification was used to find the ideal cooking conditions (5h07 min, 104.2°C) which could be satisfactory for the maximization of delignification (70.5%) and pulp yield (58.7%) and, to a lesser extent, for the minimization of 2-furfural production. Treatment conditions were found to influence the chemical structure of extracted lignins. Cooking time and temperature influenced inversely lignin molecular weights. [less ▲]Detailed reference viewed: 49 (30 ULg) Higher long-lasting ethanol sensitization after adolescent ethanol exposure in miceQuoilin, Caroline; Didone, Vincent ; Tirelli, Ezio et alin Psychopharmacology (2014), 231Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is ... [more ▼]Rationale. Due to their maturing brain, adolescents are suggested to be more vulnerable to the long-term consequences of chronic alcohol use. Increased sensitization to the stimulant effects of ethanol is a possible consequence of ethanol exposure during adolescence. Objectives. The aim of this study was to characterize the long-term alterations in the stimulant effects of ethanol and in the rate of ethanol sensitization in mice pre-exposed to ethanol during adolescence in comparison to mice pre-exposed to ethanol in adulthood. Methods. Adolescent and adult female SWISS mice were injected with saline or ethanol (2.5 or 4 g/kg) during 14 consecutive days. After a three weeks period of ethanol abstinence, mice were tested as adults before and after a second exposure to daily repeated ethanol injections. Results. All mice pre-exposed to ethanol as adults or adolescents showed higher stimulant effects when re-exposed to ethanol three weeks later. However, this enhanced sensitivity to the stimulant effects of ethanol was of significantly higher magnitude in mice repeatedly injected with high ethanol doses (4g/kg) during adolescence. Furthermore, the increased expression of ethanol stimulant effects in these mice was maintained even after a second procedure of ethanol sensitization. Conclusions. Adolescence is a critical period for the development of a sensitization to ethanol stimulant properties providing that high intermittent ethanol doses are administered. These results might contribute to explain the relationship between age at first alcohol use and risks of later alcohol problems and highlight the dangers of repeated consumption of high alcohol amounts in young adolescents. [less ▲]Detailed reference viewed: 23 (8 ULg) Les modifications du fonctionnement exécutif dans le vieillissement normalCollette, Fabienne ; Salmon, Eric in Psychologie Française (2014), 59(1), 41-58Il est maintenu bien reconnu que le vieillissement cognitif est associé à une diminution des capacités exécutives. Toutefois, si des déficits sont effectivement observés au sein des différentes fonctions ... [more ▼]Il est maintenu bien reconnu que le vieillissement cognitif est associé à une diminution des capacités exécutives. Toutefois, si des déficits sont effectivement observés au sein des différentes fonctions, des dissociations entre performances préservées/altérées ont également été observées au sein de chacune. Dans cette revue de question, nous détaillerons les effets du vieillissement dans les fonctions de mise à jour, flexibilité, inhibition et coordination de tâches doubles, ainsi que les modifications au sein des réseaux cérébraux associés à ces processus. Nous discuterons également l'influence des capacités attentionnelles, des ressources en mémoire de travail et de certaines caractéristiques génétiques sur ces modifications. [less ▲]Detailed reference viewed: 151 (20 ULg) Disorders of consciousness after acquired brain injury: the state of the scienceGiacino, Joseph T; Fins, Joseph J; Laureys, Steven et alin Nature Reviews Neurology (2014)The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain ... [more ▼]The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest. [less ▲]Detailed reference viewed: 61 (2 ULg) Evidence-based practice: fondements et réflexions sur l’apport en clinique.Maillart, Christelle ; Durieux, Nancy in Langage et Pratiques (2014), 53L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant ... [more ▼]L’evidence-based practice ou pratique basée sur les preuves est une approche de plus en plus encouragée en logopédie au niveau international. Cet article présente les principaux composants en détaillant la nature des preuves liées aux trois piliers de l’EBP (preuves externes, preuves internes ou préférences du patient). La démarche de l’EBP est brièvement discutée ainsi que les freins et les bénéfices attendus en clinique. [less ▲]Detailed reference viewed: 32 (4 ULg) Could the chemical contamination be the cause of the increase in the number of stranded harbour porpoises (Phocoena phocoena) along the Southern North Sea?Mahfouz, C.; Henry, F.; Pezeril, S. et alin Environmental Research (2014)Detailed reference viewed: 2 (0 ULg) Bayesian methods for predicting LAI and soil water contentMansouri, Majdi ; Dumont, Benjamin ; Leemans, Vincent et alin Precision Agriculture (2014), 15(2), 184-201LAI of winter wheat (Triticum aestivum L.) and soil water content of the topsoil (200 mm) and of the subsoil (500 mm) were considered as state variables of a dynamic soil-crop system. This system was ... [more ▼]LAI of winter wheat (Triticum aestivum L.) and soil water content of the topsoil (200 mm) and of the subsoil (500 mm) were considered as state variables of a dynamic soil-crop system. This system was assumed to progress according to a Bayesian probabilistic state space model, in which real values of LAI and soil water content were daily introduced in order to correct the model trajectory and reach better future evolution. The chosen crop model was mini STICS which can reduce the computing and execution times while ensuring the robustness of data processing and estimation. To predict simultaneously state variables and model parameters in this non-linear environment, three techniques were used: Extended Kalman Filtering (EKF), Particle Filtering (PF), and Variational Filtering (VF). The significantly improved performance of the VF method when compared to EKF and PF is demonstrated. The variational filter has a low computational complexity and the convergence speed of states and parameters estimation can be adjusted independently. Detailed case studies demonstrated that the root mean square error (RMSE) of the three estimated states (LAI and soil water content of two soil layers) was smaller and that the convergence of all considered parameters was ensured when using VF. Assimilating measurements in a crop model allows accurate prediction of LAI and soil water content at a local scale. As these biophysical properties are key parameters in the crop-plant system characterization, the system has the potential to be used in precision farming to aid farmers and decision makers in developing strategies for site-specific management of inputs, such as fertilizers and water irrigation. [less ▲]Detailed reference viewed: 42 (14 ULg) Lectures de La Reine Albemarle ou le dernier touriste. Ontologie, autobiographie, politiqueCormann, Grégory in Bulletin d'Analyse Phénoménologique (2014), 10(1), Detailed reference viewed: 30 (4 ULg) DeltaNp63 isoform-mediated beta-defensin family up-regulation is associated with (lymph)angiogenesis and poor prognosis in patients with squamous cell carcinoma.Suarez-Carmona, Meggy ; Hubert, Pascale ; Gonzalez, Arnaud et alin Oncotarget (2014), sous presseBeside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype ... [more ▼]Beside a role in normal development/differentiation, high p63 immunoreactivity is also frequently observed in squamous cell carcinoma (SCC). Due to the complexity of the gene, the role of each p63 isotype in tumorigenesis is still confusing. Constitutively produced or induced in inflammatory conditions, human beta-defensins (HbetaDs) are cationic peptides involved in host defenses against bacteria, viruses and fungi. Here, we investigated both the role of p63 proteins in the regulation of HbetaDs and the implication of these antimicrobial peptides in tumor (lymph)angiogenesis. Thus, in contrast to TAp63 isotypes, we observed that DeltaNp63 proteins (alpha, beta, gamma) induce HbetaD1, 2 and 4 expression. Similar results were observed in cancer tissues and cell lines. We next demonstrated that DeltaNp63-overexpressing SCC are associated with both a poor prognosis and a high tumor vascularisation and lymphangiogenesis. Moreover, we showed that HbetaDs exert a chemotactic activity for (lymphatic) endothelial cells in a CCR6-dependent manner. The ability of HbetaDs to enhance (lymph)angiogenesis in vivo was also evaluated. We observed that HbetaDs increase the vessel number and induce a significant increase in relative vascular area compared to negative control. Taken together, the results of this study suggest that DeltaNp63-regulated HbetaD could promote tumor (lymph)angiogenesis in SCC microenvironment. [less ▲]Detailed reference viewed: 22 (3 ULg) Light modulation of human sleep depends on a polymorphism in the clock gene PER3Chellappa, Sarah Laxhmi ; Viola, Antoine; Schmidt, Christina et alin Behavioural Brain Research (2014), 271Detailed reference viewed: 6 (0 ULg) Prevalence of Campylobacter among goats and retail goat meat in CongoKabwang a Mpalang, Rosette; BOREUX, Raphaël ; Melin, Pierrette et alin Journal of Infection in Developing Countries [=JIDC] (2014), 8Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A ... [more ▼]Background: The prevalence of Campylobacter jejuni and Campylobacter coli was determined in goat and goat meat sold at retail outlets in Lubumbashi, Democratic Republic of Congo (DR Congo). Methodology: A total of 644 samples, including 177 goat meat, 86 goat stomachs, 139 ready to eat (RTE) goat skewers, and 242 goat faecal samples were examined for the presence of Campylobacter jejuni and Campylobacter coli using polymerase chain reaction. Results: Overall, Campylobacter spp. were found in 34.6% of the examined samples. C. jejuni was isolated in 10.1% and C. coli in 26.7% of samples. Only 2.2% of all samples were positive for both species. There was a significant association between the prevalence of C. coli and the type of sample (p < 0.05). The overall prevalence of Campylobacter in different sample groups was 41.2%, 37.2%, 23.7%, and 35.1% for goat meat, goat stomachs, RTE goat skewers, and goat faecal samples, respectively. There was no significant difference (p > 0.05) between the prevalence observed in the rainy season (16.7%) and the dry season (20.0%). Moreover, the overall prevalence of Campylobacter in slaughter sites, open-air markets, warehouses, and semi-open-air markets was 28.2%, 34.2%, 35.4%, and 42.9%, respectively. Statistically, there was no influence of the sample collection site on the frequency of isolation of Campylobacter (p > 0.05). Conclusion: This study shows that, considering the relatively high prevalence of this [less ▲]Detailed reference viewed: 11 (0 ULg) Lower Carboniferous Rugose corals from the Arabian Plate: an insight from the Hakkari area (SE Turkey)Denayer, Julien ; Hoşgörin Journal of Asian Earth Sciences (2014), 79(1), 345-357Detailed reference viewed: 32 (3 ULg) Genetic basis of congenital erythrocytosis: mutation update and online databases.Bento, Celeste; Percy, Melanie J.; Gardie, Betty et alin Human mutation (2014), 35(1), 15-26Congenital erythrocytosis (CE), or congenital polycythemia, represents a rare and heterogeneous clinical entity. It is caused by deregulated red blood cell production where erythrocyte overproduction ... [more ▼]Congenital erythrocytosis (CE), or congenital polycythemia, represents a rare and heterogeneous clinical entity. It is caused by deregulated red blood cell production where erythrocyte overproduction results in elevated hemoglobin and hematocrit levels. Primary congenital familial erythrocytosis is associated with low erythropoietin (Epo) levels and results from mutations in the Epo receptor gene (EPOR). Secondary CE arises from conditions causing tissue hypoxia and results in increased Epo production. These include hemoglobin variants with increased affinity for oxygen (HBB, HBA mutations), decreased production of 2,3-bisphosphoglycerate due to BPGM mutations, or mutations in the genes involved in the hypoxia sensing pathway (VHL, EPAS1, and EGLN1). Depending on the affected gene, CE can be inherited either in an autosomal dominant or recessive mode, with sporadic cases arising de novo. Despite recent important discoveries in the molecular pathogenesis of CE, the molecular causes remain to be identified in about 70% of the patients. With the objective of collecting all the published and unpublished cases of CE the COST action MPN&MPNr-Euronet developed a comprehensive Internet-based database focusing on the registration of clinical history, hematological, biochemical, and molecular data (http://www.erythrocytosis.org/). In addition, unreported mutations are also curated in the corresponding Leiden Open Variation Database. [less ▲]Detailed reference viewed: 13 (1 ULg) Simbirskiasaurus and Pervushovisaurus reassessed: implications for the taxonomy and cranial osteology of Cretaceous platypterygiine ichthyosaursFischer, Valentin ; Arkhangelsky, Maxim; Stenshin, Ilya et alin Zoological Journal of the Linnean Society (2014), 171(4), 822841The ichthyosaur fossil record is interspersed by several hiatuses, notably during the Cretaceous. This hampers our understanding of the evolution and extinction of this group of marine reptiles during the ... [more ▼]The ichthyosaur fossil record is interspersed by several hiatuses, notably during the Cretaceous. This hampers our understanding of the evolution and extinction of this group of marine reptiles during the last 50 million years of its history. Several Cretaceous ichthyosaur taxa named in the past have subsequently been dismissed and referred to the highly inclusive taxon Platypterygius, a trend that has created the impression of low Cretaceous ichthyosaur diversity. Here, we describe the cranial osteology, reassess the stratigraphic age, and evaluate the taxonomy and phylogenetic relationships of two Cretaceous ichthyosaurs from western Russia: Simbirskiasaurus birjukovi from the early Barremian and Pervushovisaurus bannovkensis from the middle Cenomanian, both formerly regarded as nomina dubia, and allocated to Platypterygius sp. and Platypterygius campylodon, respectively. We show that Simbirskiasaurus birjukovi and Pervushovisaurus bannovkensis are valid platypterygiine ophthalmosaurids, notably characterized by a peculiar narial aperture. The cranial anatomy and phylogenetic relationships of these taxa illuminate the evolution of narial aperture anatomy in Cretaceous ichthyosaurs, clarify the phylogenetic relationships among platypterygiines, and provide further arguments for a thorough revision of Platypterygius. [less ▲]Detailed reference viewed: 16 (1 ULg) Edgar Allan Poe : vers une poétique du maelström. De la traduction de la "Lettre" à l'espace clos littéraireKüpper, Achim in Orbis Litterarum (2014), 69Detailed reference viewed: 7 (0 ULg) Extraction by three processes of arabinoxylans from wheat bran and characterization of the fractions obtainedAguedo, Mario ; Fougnies, Christian; DERMIENCE, Michael et alin Carbohydrate Polymers (2014), 105Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified ... [more ▼]Arabinoxylans (AXs) were extracted from destarched wheat bran (DWB) according to different processes, with a view to their production at industrial scale. Two fractions (F3a and F3b, respectively purified on 10 kDa and 100 kDa ultrafiltration membranes) were obtained with low yields by treating DWB with an endoxylanase and this process left a solid residue exhausted in enzyme-extractable AXs (EDWB). F1 and F2 AX fractions were obtained by treatment with sodium hydroxide of respectively DWB and EDWB. The fraction F4 resulted from a hydrothermal treatment of EDWB in a pressure reactor, followed by ethanol precipitation. The different AX fractions were characterized and compared for the composition in monosaccharides, for the contents in fats and in ferulic, phytic and uronic acids, for the molecular mass distribution and the degrees of methylation and acetylation. The alkaline extractions gave one desesterified AX population with molecular mass (MM) higher than 670 kDa and arabinose/xylose ratios (Ara/Xyl) around 1. The enzyme and thermal treatments yielded AXs with two main populations in size-exclusion chromatography (the largest one at 5-12.5 kDa and a second one at 140-160 kDa), having overall Ara/Xyl of respectively 0.7 and 0.5 for both processes. These data bring information about the influence of the process on the characteristics of AX fractions obtained from pretreated wheat bran. Here are also reported processes that enabled to recover enzyme-unextractable AXs from DWB, including an original and up-scalable hydrothermal extraction. Phytate contents of isolated AXs are described for the first time. [less ▲]Detailed reference viewed: 27 (8 ULg) La Radiothérapie: le parcours du patient, de l’information au traitementLENNERTS, Eric ; COUCKE, Philippe in Revue Médicale de Liège (2014), 69(Supp 1), 3-8La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise ... [more ▼]La radiothérapie fait partie intégrante de l’arsenal thérapeutique en oncologie et on estime que deux tiers des patients cancéreux vont bénéficier d’une radiothérapie à un moment ou un autre de leur prise en charge. Le parcours d’un patient en radiothérapie est pourtant souvent méconnu du corps médical et le but de cet article est de retracer celui- ci. De la prise de décision de réaliser de la radiothérapie en concertation multidisciplinaire à la délivrance des rayons par les accélérateurs linéaires, il y a la première rencontre avec le radiothérapeute, la simulation, la délimitation des volumes et la planification du traitement. La mise en route d’un trai - tement de radiothérapie demande du temps et beaucoup de précision à chaque étape. Les technologies évoluent constam - ment et la recherche en matière d’amélioration du traitement est une priorité. Le but est d’arriver à adapter individuelle - ment le traitement de radiothérapie. [less ▲]Detailed reference viewed: 18 (6 ULg) Pt/C catalyst for PEM fuel cells: Control of Pt nanoparticles characteristics through a novel plasma deposition methodLaurent-Brocq, Mathilde; Job, Nathalie ; Eskenazi, David et alin Applied Catalysis B : Environmental (2014), 147Detailed reference viewed: 21 (1 ULg) Light modulation of human sleep depends on a polymorphism in the clock gene Period3.Chellappa, Sarah Laxhmi ; Viola, Antoine U.; Schmidt, Christina et alin Behavioural brain research (2014), 271Non-image-forming (NIF) responses to light powerfully modulate human physiology. However, it remains scarcely understood how NIF responses to light modulate human sleep and its EEG hallmarks, and if there ... [more ▼]Non-image-forming (NIF) responses to light powerfully modulate human physiology. However, it remains scarcely understood how NIF responses to light modulate human sleep and its EEG hallmarks, and if there are differences across individuals. Here we investigated NIF responses to light on sleep in individuals genotyped for the PERIOD3 (PER3) variable-number tandem-repeat (VNTR) polymorphism. Eighteen healthy young men (20-28 years; mean+/-SEM: 25.9+/-1.2) homozygous for the PER3 polymorphism were matched by age, body-mass index, and ethnicity. The study protocol comprised a balanced cross-over design during the winter, during which participants were exposed to either light of 40lx at 6500K (blue-enriched) or light at 2500K (non-blue enriched), during 2h in the evening. Compared to light at 2500K, light at 6500K induced a significant increase in all-night NREM sleep slow-wave activity (SWA: 1.0-4.5Hz) in the occipital cortex for PER3(5/5) individuals, but not for PER3(4/4) volunteers. Dynamics of SWA across sleep cycles revealed increased occipital NREM sleep SWA for virtuallyall sleep episode only for PER3(5/5) individuals. Furthermore, they experienced light at 6500K as significantly brighter. Intriguingly, this subjective perception of brightness significantly predicted their increased occipital SWA throughout the sleep episode. Our data indicate that humans homozygous for the PER3(5/5) allele are more sensitive to NIF light effects, as indexed by specific changes in sleep EEG activity. Ultimately, individual differences in NIF light responses on sleep may depend on a clock gene polymorphism involved in sleep-wake regulation. [less ▲]Detailed reference viewed: 7 (0 ULg)