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See detail2D dynamic studies combined with the surface curvature analysis to predict Arias Intensity amplification
Torgoev, Almazbek ULg; Havenith, Hans-Balder ULg

in Journal of Seismology (2016)

A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings ... [more ▼]

A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings of the landslide-prone slopes situated in the Mailuu-Suu River Valley, Southern Kyrgyzstan. The main studied parameter is the Arias Intensity (Ia, m/sec), which is applied in the GIS-based Newmark method to regionally map the seismically-induced landslide susceptibility. This method maps the Ia values via empirical attenuation laws and our studies investigate a potential to include topographic input into them. Numerical studies analyse several signals with varying shape and changing central frequency values. All tests demonstrate that the spectral amplification patterns directly affect the amplification of the Ia values. These results let to link the 2D distribution of the topographically amplified Ia values with the parameter called as smoothed curvature. The amplification values for the low-frequency signals are better correlated with the curvature smoothed over larger spatial extent, while those values for the high-frequency signals are more linked to the curvature with smaller smoothing extent. The best predictions are provided by the curvature smoothed over the extent calculated according to Geli’s law. The sample equations predicting the Ia amplification based on the smoothed curvature are presented for the sinusoid-shape input signals. These laws cannot be directly implemented in the regional Newmark method, as 3D amplification of the Ia values addresses more problem complexities which are not studied here. Nevertheless, our 2D results prepare the theoretical framework which can potentially be applied to the 3D domain and, therefore, represent a robust basis for these future research targets. [less ▲]

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See detailHigh Prevalence of Plasmodium falciparum Infection in Asymptomatic Individuals from the Democratic Republic of the Congo
Mvumbi, Dieudonné; Bobanga, Thierry; Melin, Pierrette ULg et al

in Malaria Research and Treatment (2016), 2016

Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHOMalaria Report in 2014. Asymptomaticmalaria cases are known to be prevalent ... [more ▼]

Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHOMalaria Report in 2014. Asymptomaticmalaria cases are known to be prevalent in endemic areas and are generally untreated,resulting in a significant source of gametocytes that may serve as reservoir of disease transmission. Considering that microscopycertainly underestimates the prevalence of Plasmodium infections within symptomatic carriers and that PCR assays are currentlyrecognized as the most sensitive methods for Plasmodium identification, this study was conducted to weigh the asymptomatic carriage in DRC by a molecular method. Six provinces were randomly selected for blood collection in which 80 to 100 individuals were included in the study. Five hundred and eighty blood sampleswere collected andmolecular diagnosiswas performed. Globally, almost half of the samples collected from asymptomatic individuals (280/580; 48.2%) had Plasmodium infections and the most species identified was P. falciparum alone in combination with P. malariae. The high prevalence reported here should interpellate the bodies involved in malaria control in DR Congo to take into account asymptomatic carriers in actions taken and consider asymptomatic malaria as a major hurdle for malaria elimination. [less ▲]

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See detailAutomatic artifacts and arousals detection in whole-night sleep EEG recordings
Coppieters't Wallant, Dorothée ULg; Muto, Vincenzo ULg; Gaggioni, Giulia ULg et al

in Journal of Neuroscience Methods (2016), 258

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time ... [more ▼]

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time consuming and subjective. To detect artifacts and arousals in a reliable, systematic and reproducible automatic way, we developed an automatic detection based on time and frequency analysis with adapted thresholds derived from data themselves. The automatic detection performance is assessed using 5 statistic parameters, on 60 whole night sleep recordings coming from 35 healthy volunteers (male and female) aged between 19 and 26. The proposed approach proves its robustness against inter- and intra-, subjects and raters’ scorings, variability. The agreement with human raters is rated overall from substantial to excellent and provides a significantly more reliable method than between human raters. Existing methods detect only specific artifacts or only arousals, and/or these methods are validated on short episodes of sleep recordings, making it difficult to compare with our whole night results. The method works on a whole night recording and is fully automatic, reproducible, and reliable. Furthermore the implementation of the method will be made available online as open source code. [less ▲]

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See detailThe Relationship between the Profile of Manager and Management Accounting Practices in Tunisian SMIs
Ghorbel, Jihene ULg

in International Journal of Academic Research in Accounting, Finance and Management Sciences (2016), 6(1), 61-72

In today’s changing environment, SMEs must strengthen their competitiveness and credibility with all their external partners. So to survive and prosper, managers need adequate management practices in ... [more ▼]

In today’s changing environment, SMEs must strengthen their competitiveness and credibility with all their external partners. So to survive and prosper, managers need adequate management practices in order to provide relevant accounting information. This paper examines the effect of profile of manager on management accounting practices which was defined in terms of traditional management accounting, modern management accounting and management accounting practices related to export. As to the profile of manager, it is defined by age, type of training and experience. To validate the hypotheses, a multiple linear regression method is used. The data is collected by questionnaire from 221 Tunisian manufacturing SMEs. The findings indicate that the profile of manager affect in part the use of management accounting practices. [less ▲]

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See detailCompte-rendu de : GÉRARD E., DE RIDDER W., MULLER F., Qui a tué Julien Lahaut ? Les ombres de la Guerre Froide en Belgique, Bruxelles, La Renaissance du Livre, 2015, 352 p.
Genin, Vincent ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2016), XXXVII(2015/4), 21-24

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See detailAn Economic Appraisal of MOOC Platforms: Business Models and Impacts on Higher Education
Jacqmin, Julien ULg; belleflamme, paul

in CESifo Economic Studies (2016), 62(1), 148-169

We use various economic and pedagogical concepts to understand the specificities of MOOC (Massive Online Open Courses) platforms. We discuss how the private provision of MOOCs can be sustained. Using the ... [more ▼]

We use various economic and pedagogical concepts to understand the specificities of MOOC (Massive Online Open Courses) platforms. We discuss how the private provision of MOOCs can be sustained. Using the theory of multisided platforms, we analyze five ways to monetize the MOOC business. We then claim that MOOC platforms can play a key transformative role in the higher education sector by making teaching practices evolve, rather than by replacing incumbent institutions. Finally, we derive a number of directions for public policy [less ▲]

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See detailEffects of seed traits variation on seedling performance of the invasive weed, Ambrosia artemisiifolia L.
Ortmans, William ULg; Mahy, Grégory ULg; Monty, Arnaud ULg

in Acta Oecologica: International Journal of Ecology (2016), 71

Seedling performance can determine the survival of a juvenile plant and impact adult plant performance. Understanding the factors that may impact seedling performance is thus critical, especially for ... [more ▼]

Seedling performance can determine the survival of a juvenile plant and impact adult plant performance. Understanding the factors that may impact seedling performance is thus critical, especially for annuals, opportunists or invasive plant species. Seedling performance can vary among mothers or populations in response to environmental conditions or under the influence of seed traits. However, very few studies have investigated seed traits variations and their consequences on seedling performance. Specifically, the following questions have been addressed by this work: 1) How the seed traits of the invasive Ambrosia artemisiifolia L. vary among mothers and populations, as well as along the latitude; 2) How do seed traits influence seedling performance; 3) Is the influence on seedlings temperature dependent. With seeds from nine Western Europe ruderal populations, seed traits that can influence seedling development were measured. The seeds were sown into growth chambers with warmer or colder temperature treatments. During seedling growth, performance-related traits were measured. A high variability in seed traits was highlighted. Variation was determined by the mother identity and population, but not latitude. Together, the temperature, population and the identity of the mother had an effect on seedling performance. Seed traits had a relative impact on seedling performance, but this did not appear to be temperature dependent. Seedling performance exhibited a strong plastic response to the temperature, was shaped by the identity of the mother and the population, and was influenced by a number of seed traits. [less ▲]

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See detailProjecting alternative urban growth patterns: The development and application of a remote sensing assisted calibration framework for the Greater Dublin Area
Van de Voorde, Tim; van der Kwast, Johannes; Poelmans, Lien et al

in Ecological Indicators (2016), 60

Land use change models are powerful tools that allow planners and policy makers to assess the long-term spatial and environmental impacts of their decisions. In order for these models to produce a ... [more ▼]

Land use change models are powerful tools that allow planners and policy makers to assess the long-term spatial and environmental impacts of their decisions. In order for these models to produce a realistic output, they should be properly calibrated. This is usually achieved by comparing simulated land-use maps of dates in the past to reference land-use maps of a corresponding date. As land-use data are often not readily or frequently available, we propose a two-stage calibration framework that includes existing land-use maps as well as remote sensing derived maps of the urban extent. Urban growth patterns for the Dublin area represented by remote sensing based maps were compared to simulated growth using spatial metrics in order to fine-tune the calibration of the MOLAND urban growth model of Dublin. We then used the calibrated model to forecast future urban growth according to four urban planning scenarios that have been defined for the Strategic Environmental Assessment of the Greater Dublin Area. We examined a selection of spatial metrics in order to determine their sensitivity to differences in spatial patterns between simulated and remote sensing derived data. We also investigated whether these metrics are useful to characterise future changes in the urban spatial structure that ensue from the planning scenarios. We found that with the exception of some metrics that strongly respond to differences in the amount of urban land, most metrics showed similar trends for simulated and remote sensing derived maps. Most metrics were also able to distinguish the growth patterns induced by the different spatial planning scenarios. The “business as usual scenario” in particular showed a clearly distinct trend compared to the other scenarios. We could also conclude that the urban growth pattern of Dublin as observed from both the remote sensing derived maps and the simulated maps of future land use seems to confirm the theory of alternating phases of diffusive growth and coalescence. [less ▲]

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See detailLe cas tunisien
Nachi, Mohamed ULg

in Revue Nouvelle (2016), 71(1), 61-68

Mise en exergue de l'importance du rôle du compromis dans la transition démocratique en Tunisie

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See detailSmall-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin
Joset, Arnaud ULg; Grammenos, Angeliki; Hoebeke, Maryse ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2016), 84(1), 153-161

The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC ... [more ▼]

The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC) liposomes doped with cholesterol. From the modelling of the experimental neutron scattering crosssections, the detailed response of the vesicle structure upon addition of increasing amounts of RAMEB up to 30 mM has been assessed. This study has been performed below and above the DMPC bilayer phase transition temperature and shows that cholesterol extraction by RAMEB is linked to a decrease of the average radius and of the aggregation number of the vesicles. This extraction takes place in a dose-dependent way until a more monodisperse population of cholesterol-free liposomes was obtained. In addition, the bilayer thickness evolution was inferred, as well as the liposome coverage by RAMEB. [less ▲]

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See detailApprendre à faire semblant. A propos de "Furyo" de Nagisa Oshima
Tomasovic, Dick ULg

in Mondes du cinéma (2016), 08

Une analyse des préceptes qui gouvernent la mise en scène du film "Furyo" d’Oshima, en insistant particulièrement sur l'analyse de la bande sonore et la présence à l'écran de David Bowie et Ryuichi ... [more ▼]

Une analyse des préceptes qui gouvernent la mise en scène du film "Furyo" d’Oshima, en insistant particulièrement sur l'analyse de la bande sonore et la présence à l'écran de David Bowie et Ryuichi Sakamoto. [less ▲]

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See detailQuand la force enfonce des portes ouvertes. Analyse du traitement de Star Wars Episode VII par la critique professionnelle et amateure.
Krywicki, Boris ULg

in Culture, le Magazine Culturel de l'Université de Liège (2016)

On a rarement aperçu des phénomènes cinématographiques de l’ampleur de Star Wars. La plupart des séances étaient déjà complètes plusieurs semaines avant la sortie du dernier épisode. Les spectateurs sont ... [more ▼]

On a rarement aperçu des phénomènes cinématographiques de l’ampleur de Star Wars. La plupart des séances étaient déjà complètes plusieurs semaines avant la sortie du dernier épisode. Les spectateurs sont tous conquis en amont par ce messie monolithique. Quand il s'agit d'aborder un film-événement comme Star Wars, la critique de cinéma se cherche. Les timides tentatives de la rigide presse professionnelle qui hésite toujours à critiquer les productions hollywoodiennes font face à des vidéos de youtubeurs décomplexés. Cet article analyse les contrats de lecture de ces différents énonciateurs et le lecteur-modèle qu'ils envisagent pour traiter de Star Wars Episode VII. [less ▲]

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See detailShaping Pulses to Control Bistable Systems: Analysis, Computation and Counterexamples
Sootla, Aivar ULg; Oyarzun, Diego; Angeli, David et al

in Automatica (2016), 63

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See detailElectrical resistivity tomography to monitor enhanced biodegradation of hydrocarbons with Rhodococcus erythropolis T902.1 at a pilot scale
Masy, Thibaut ULg; Caterina, David; Tromme, Oliver et al

in Journal of Contaminant Hydrology (2016), 184

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of ... [more ▼]

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of such a technique (by biostimulation or bioaugmentation) strongly depends on the environment affected and is still difficult to predict a priori. In order to overcome these uncertainties, Electrical Resistivity Tomography (ERT) appears as a valuable non-invasive tool to detect soil heterogeneities and to monitor biodegradation. The main objective of this study was to isolate an electrical signal linked to an enhanced bacterial activity with ERT, in an aged HC-contaminated clayey loam soil. To achieve this, a pilot tank was built to mimic field conditions. Compared to a first insufficient biostimulation phase, bioaugmentation with Rhodococcus erythropolis T902.1 led to a HC depletion of almost 80% (6900 to 1600 ppm) in 3 months in the center of the contaminated zone, where pollutants were less bioavailable. In the meantime, lithological heterogeneities and microbial activities (growth and biosurfactant production) were successively discriminated by ERT images. In the future, this cost-effective technique should be more and more transferred to the field in order to monitor biodegradation processes and assist in selecting the most appropriate remediation technique. [less ▲]

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See detailFLOR-ID: an interactive database of flowering-time gene networks in Arabidopsis thaliana
Bouché, Frédéric ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

in Nucleic Acids Research (2016), 44(Database), 11671171

Flowering is a hot topic in Plant Biology and important progress has been made in Arabidopsis thaliana toward unravelling the genetic networks involved. The increasing complexity and the explosion of ... [more ▼]

Flowering is a hot topic in Plant Biology and important progress has been made in Arabidopsis thaliana toward unravelling the genetic networks involved. The increasing complexity and the explosion of literature however require development of new tools for information management and update. We therefore created an evolutive and interactive database of flowering time genes, named FLOR-ID (Flowering-Interactive Database), that is available freely at http://www.flor-id.org. The hand-curated database contains information on 306 genes and links to 1595 publications gathering the work of more than 4500 authors. Gene function and interactions within the flowering pathways were inferred from the analysis of related publications, included in the database and translated into interactive manually drawn snapshots. [less ▲]

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (2016), 41(1), 113-130

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailGenetic diversity and population structure of the Eurosian otte (Lutra lutra) in France
Geboes, Anne-Laure ULg; Rosoux, René; Lemarchand, Charles et al

in Mammal Research (2016), 61(1),

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before ... [more ▼]

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before the recolonisation process, two main populations still remained along the Atlantic coast and in the Massif Central. To investigate the impact of this decline on the genetic diversity and structure of the French otter population, tissue samples of 144 otter carcasses from road kills that were found during 1992–2011 along the Atlantic coast and in the Massif Central were used. They were analysed using 10 microsatellites loci. Observed (Ho = 0.64) and expected heterozygosity (He = 0.62) were moderate, but consistent with results found in other European populations. The bottleneck test showed an excess of heterozygotes, providing evidence of a recent decline. There was evidence for weak but significant allelic frequencies divergence between otters from the Atlantic coast and those from the Massif Central (Fst=0.040, p<0.05), probably resulting from their isolation prior to the recolonisation process. As the French otter population has been expanding for several years, genetic intermixing is now occurring. Although this expansion has not yet genetically homogenised all populations, this is may be a matter a time. [less ▲]

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See detailComment je traite... la sténose aortique asymptomatique
MEURICE, Caroline ULg; DULGHERU, Raluca Elena ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), (71), 6-10

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See detailPre-employement examination for low back risk in workers exposesd to manual handling of loads : French guidelines
PETIT, Audrey; ROUSSEAU, Sandrine; HUEZ, Jean-François et al

in International Archives of Occupational and Environmental Health (2016), 89

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See detailL’infraction d’obstacle à la surveillance sous le spectre du droit au silence et du droit de ne pas s’auto-incriminer
Michiels, Olivier ULg; Falque, Géraldine ULg

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2016), (2006/1), 2-11

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne ... [more ▼]

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne pas s'auto-incriminer. Il envisage encore la cohabitation entre le délit d'obstacle et le droit au silence sous l’angle de la jurisprudence de la Cour européenne des droits de l’homme et du droit interne. [less ▲]

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See detailarchiDART: an R package for the automated computation of plant root architectural traits
Delory, Benjamin ULg; Baudson, Caroline ULg; Brostaux, Yves ULg et al

in Plant and Soil (2016), 398(1), 351-365

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software ... [more ▼]

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software packages have been developed. These tools offer complementary approaches to study RSAs and the use of the Root System Markup Language (RSML) to store RSA data makes the comparison of measurements obtained with different (semi-) automated root imaging platforms easier. The throughput of the data analysis process using exported RSA data, however, should benefit greatly from batch analysis in a generic data analysis environment (R software). Methods We developed an R package (archiDART) with five functions. It computes global RSA traits, root growth rates, root growth directions and trajectories, and lateral root distribution from DART-generated and/or RSML files. It also has specific plotting functions designed to visualise the dynamics of root system growth. Results The results demonstrated the ability of the package’s functions to compute relevant traits for three contrasted RSAs (Brachypodium distachyon [L.] P. Beauv., Hevea brasiliensis Müll. Arg. and Solanum lycopersicum L.). Conclusions This work extends the DART software package and other image analysis tools supporting the RSML format, enabling users to easily calculate a number of RSA traits in a generic data analysis environment. [less ▲]

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See detailRe-visiting plant plasma membrane lipids in tobacco: a focus on sphingolipids
Cacas, Jean Luc; Buré, Corinne; Grosjean, Kevin et al

in Plant Physiology (2016), 170

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See detailDeterminants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Cavalier, Etienne ULg et al

in Osteoporosis International (2016), 27

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 ... [more ▼]

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. Introduction The aim of this study is to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Methods General practitioners (GPs) having at least one patient in a nursing home in Liège, Belgium, were asked to complete the survey. Results A total of 119 GPs participated in the survey. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. The main reasons for prescribing vitamin D cited by GPs who do so systematically are as follows: because they believe nursing home residents are mostly deficient in vitamin D status (92.1 %), because they believe that vitamin D supplementation prevents osteoporotic fractures (77.8 %), and because vitamin D supplementation is recommended by various scientific societies (38.1 %). GPs who only prescribe vitamin D supplementation in some patients mainly do so following a diagnosis of osteoporosis (82.4 %), on the basis the 25(OH)D level (78.4 %), in the case of history of fracture (54.9 %) or after a recent fracture (43.4 %). Surprisingly, 16 physicians (31.4 %) only prescribe vitamin D when they think of it. Interestingly, while 40.7% of GPs always prescribe the same dose of vitamin D, the remaining 59.3 % prescribe a dose that will mainly depend on the results of the 25(OH)D level (94.0 %), the patient’s bone health (49.3 %), or history of fracture (43.3 %). Conclusions More than half of GPs systematically prescribe vitamin D to their patients living in nursing homes. The other GPs usually prescribe vitamin D following the result of the vitamin D status or after a diagnosis of osteoporosis. [less ▲]

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See detailNos différences, une richesse
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailThe effects of a documentary film about schizophrenia on cognitive, affective and behavioural aspects of stigmatisation
Thonon, Bénédicte ULg; Pletinx, Amandine; Grandjean, Allison et al

in Journal of Behavior Therapy and Experimental Psychiatry (2016), 50

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to ... [more ▼]

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to develop interventions aiming to prevent, reduce or eliminate such stereotypes. The aim of this study was to evaluate the effects of a documentary film on schizophrenia on cognitive, affective and behavioural aspects of stigmatisation. Methods: Forty-nine participants were assessed on measures of stereotypes and social distance, and on the Model of Stereotype Content, which includes measures of stereotypes, emotional reactions and behavioural tendencies. Participants were randomly assigned into either a condition in which they viewed the documentary film (Film group), or into a control condition in which no intervention was conducted (Control group). Results: Only participants in the Film group revealed a significant decrease of negative stereotypes (Dangerousness and Unpredictability) and desired Social distance, and a significant increase in the perception of sociability in persons with schizophrenia. Limitations: Small sample size and its reduced generalizability are the main limitations in this study. Conclusions: These findings suggest that a documentary film promoting indirect contact with people diagnosed with schizophrenia is a promising tool to prevent and reduce stigmatisation regarding schizophrenia. [less ▲]

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See detailCost-effectiveness of personalized supplementation with vitamin D-rich dairy products in the prevention of osteoporotic fractures
Ethgen, Olivier ULg; Hiligsmann, Mickaël; Burlet, Nansa et al

in Osteoporosis International (2016), 27

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of ... [more ▼]

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of osteoporotic fractures. Introduction: The objective of this study is to assess the costeffectiveness of the vitamin D-fortified yogurt given to women with and without an increased risk of osteoporotic fracture. Methods: Avalidated cost-effectiveness microsimulation Markov model of osteoporosis management was used. Three personalized supplementation scenarios to reflect the Ca/Vit D needs taking into account the well-known variations in dietary habits and a possible pharmacological supplementation in Ca/ Vit D, given above or in combination with anti-osteoporosis medications: one yogurt per day, i.e., 400 mg of Ca+200 IU of Vit D (scenario 1 U), two yogurts per day, i.e., 800 mg of Ca+ 400 IU of Vit D (scenario 2 U), or three yogurts per day, i.e., 1, 200 mg of Ca+600 IU of Vit D (scenario 3 U). Results: One yogurt is cost-effective in the general population above the age of 70 years and in all age groups in women with low bone mineral density (BMD) or prevalent vertebral fracture (PVF). The daily intake of two yogurts is cost-effective above 80 years in the general population and above 70 years in the two groups of women at increased risk of fractures. However, an intake of three yogurts per day is only cost-effective above 80 years old in the general population, as well as in women with low BMD or PVF. Conclusions: Our study is the first economic analysis supporting the cost-effectiveness of dairy products, fortified with vitamin D, in the armamentarium against osteoporotic fractures. [less ▲]

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See detailL'observation foncière en France, à Bruxelles et en Flandre
Hendrickx, Sébastien ULg; Sarciat, Jordane ULg; Halleux, Jean-Marie ULg

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2016), 64

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques ... [more ▼]

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques d’aménagement du territoire et des politiques sectorielles. La note de recherche n° 64 s’intéresse aux pratiques d’observation dans les territoires adjacents à la Wallonie et plus exactement aux outils développés en France, en Flandre et en Région de Bruxelles-Capitale. L’analyse de ces différents cas a mis en exergue l'avance évidente de nos voisins sur ces problématiques et permet d'apprécier l’utilité d’une connaissance territoriale accrue pour l’élaboration des stratégies de développement territorial et pour la prise de décision politique. Elle aboutit à diverses recommandations relatives à l’amélioration du système d’informations foncières et des politiques foncières en Wallonie. [less ▲]

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See detailEtude de cas: l'attentat au Musée juif de Bruxelles
Debras, François ULg

in Politique : Revue de Débats (2016), 93

L’attaque soudaine d’un homme qui fait irruption dans un lieu public et tue quatre individus est angoissante. Les catastrophes, les drames et les malheurs qui frappent la société sont porteurs de ... [more ▼]

L’attaque soudaine d’un homme qui fait irruption dans un lieu public et tue quatre individus est angoissante. Les catastrophes, les drames et les malheurs qui frappent la société sont porteurs de nombreuses questions : qui, comment, pourquoi, dans quel but,… ? Les théories du complot permettent de répondre à un besoin social, celui de comprendre. Le complot est d’autant plus attirant et convaincant qu’il apporte une réponse simple, globale et dépouillée de toute subtilité. [less ▲]

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See detailCross-Modal Decoding of Neural Patterns Associated with Working Memory: Evidence for Attention-Based Accounts of Working Memory
Majerus, Steve ULg; Cowan, Nelson; Peters, Frédéric ULg et al

in Cerebral Cortex (2016), 26

Recent studies suggest common neural substrates involved in verbal and visual working memory (WM), interpreted as reflecting shared attention-based, short-term retention mechanisms. We used a machine ... [more ▼]

Recent studies suggest common neural substrates involved in verbal and visual working memory (WM), interpreted as reflecting shared attention-based, short-term retention mechanisms. We used a machine-learning approach to determine more directly the extent to which common neural patterns characterize retention in verbal WM and visual WM. Verbal WM was assessed via a standard delayed probe recognition task for letter sequences of variable length. Visual WM was assessed via a visual array WM task involving the maintenance of variable amounts of visual information in the focus of attention. We trained a classifier to distinguish neural activation patterns associated with high- and low-visual WM load and tested the ability of this classifier to predict verbal WM load (high–low) from their associated neural activation patterns, and vice versa. We observed significant between-task prediction of load effects during WM maintenance, in posterior parietal and superior frontal regions of the dorsal attention network; in contrast, between-task prediction in sensory processing cortices was restricted to the encoding stage. Furthermore, between-task prediction of load effects was strongest in those participants presenting the highest capacity for the visual WM task. This study provides novel evidence for common, attention-based neural patterns supporting verbal and visual WM. [less ▲]

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See detailOverview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in American Journal of Analytical Chemistry (2016), 7

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See detailVaricella paediatric hospitalisations in Belgium: a 1-year national survey.
Blumental, Sophie; Sabbe, Martine; Lepage, Philippe et al

in Archives of disease in childhood (2016), 101(1), 16-22

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real ... [more ▼]

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. METHODS: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. RESULTS: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/10(5) person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/10(5) person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had >/=1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/552) received acyclovir. Incidence of complicated hospitalised cases was 19/10(5) person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/10(6) and fatality ratio 0.2% among our cohort. CONCLUSIONS: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium. [less ▲]

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See detailĐánh giá tiềm năng bã rượu làm thức ăn chăn nuôi lợn nông hộ tại ba tỉnh phía Bắc
Nguyen Cong, Oanh ULg; Pham Kim, Dang; Vu Dinh, Ton et al

in Journal of Science and Development (2016), 14(1), 79-86

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were ... [more ▼]

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were surveyed and 18 samples of rice distiller’s by-product were collected from 3 traditional alcohol villages belonging to 3 different provinces in the North of Viet Nam (Hai Duong, Hung Yen and Bac Giang). The study results showed that rice distillers’ by product was produced in large quantity and available the whole year round in households surveyed (8.266 kg DM/household/year). The majority of this by-product was used for pig production. The rice distiller’s by-product use in feed ration varied between 11- 40% DM and 11-50% DM for sows and fattening pigs, respectively. For the sows, this by-product used in diet gradually reduced from pregnancy to milking sows. For the fattening pigs, its by-product is used continuously from piglet to finishing stage. Rice distiller’s by-product was high in protein, NDF (% DM) and energy (28.18%, 29.93% and 4.866,67 kcal/kg, respectively) but low in dry matter (DM) (11.04%). The low pH value (3.19) and high lactic acid ratio (2.31 g/100 g sample) might help improve digestive health and prevent intestinal diseases. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Thrombose veineuse ovarienne gauche et extension à la veine rénale
JEAN, FLORENCE; CLAUDOT, A.; ISTACE, B. et al

in Revue Médicale de Liège (2016), 71(1), 17-21

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of ... [more ▼]

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of cases. The usual clinical features include abdominal pain, fever and leucocytosis. However, the diagnosis is often complicated by other non specific signs and symptoms. Ovarian vein thrombosis may cause sepsis, pulmonary thromboembolism, and thrombosis of the inferior vena cava and the renal vein. The diagnosis can be established by CT scan or nuclear magnetic resonance imaging, which has a high sensitivity and specificity. Treatment for the ovarian vein thrombosis includes antibiotics and anticoagulation. The complications can sometimes be surgically managed. Prompt diagnosis and treatment can decrease the morbidity and the mortality. Nowadays, the fatal issue is rare as the appropriate treatment is quickly instaured. [less ▲]

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See detailEffect of coil orientation on strength-duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation
D'Ostilio, Kevin ULg; Goetz, Stefan; Hannah, Ricci et al

in Clinical Neurophysiology (2016), 1

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central ... [more ▼]

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central sulcus. Methods: Motor threshold and input–output curve, along with motor evoked potential (MEP) latencies, of first dorsal interosseus were determined at pulse widths of 30, 60, and 120 μs using a controllable pulse parameter (cTMS) device, with the coil oriented PA or AP. These were used to estimate the S-D time constant and we compared with data for responses evoked by cTMS of the ulnar nerve at the elbow. Results: The S-D time constant with PA was shorter than for AP stimulation (230.9 ± 97.2 vs. 294.2 ± 90.9 us; p<0.001). These values were similar to those calculated after stimulation of ulnar nerve (197 ± 47us). MEP latencies to AP, but not PA stimulation were affected by pulse width, showing longer latencies following short duration stimuli. Conclusion: PA and AP stimuli appear to activate the axons of neurons with different time constants. Short duration AP pulses are more selective than longer pulses in recruiting longer latency corticospinal output. [less ▲]

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See detailA numerical study of hypoelastic and hyperelastic large strain viscoplastic Perzyna type models
Careglio, Claudio; Canales Cardenas, Cristian ULg; García Garino, Carlos et al

in Acta Mechanica (2016)

For the case ofmetalswith large viscoplastic strains, it is necessary to define appropriate constitutive models in order to obtain reliable results from the simulations. In this paper, two large strain ... [more ▼]

For the case ofmetalswith large viscoplastic strains, it is necessary to define appropriate constitutive models in order to obtain reliable results from the simulations. In this paper, two large strain viscoplastic Perzyna type models are considered. The first constitutive model has been proposed by Ponthot, and the elastic response is based on hypoelasticity. In this case, the kinematics of the constitutive model is based on the additive decomposition of the rate deformation tensor. The second constitutive model has been proposed by García Garino et al., and the elastic response is based on hyperelasticity. In this case, the kinematics of the constitutive model is based on the multiplicative decomposition of the deformation gradient tensor. In both cases, the resultant numerical models have been implemented in updated Lagrangian formulation. In this work, global and local numerical results of the mechanical response of both constitutive models are analyzed and discussed. To this end, numerical experiments are performed and different parameters of the constitutive models are tested in order to study the sensitivity of the resultant algorithms. In particular, the evolution of the reaction forces, the effective plastic strain, the deformed shapes and the sensitivity of the numerical results to the finite element mesh discretization have been compared and analyzed. The obtained results show that both models have a very good agreement and represent very well the characteristic of the viscoplastic constitutive model. [less ▲]

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See detailEffects of Methylmercury on Harbour Seal Peripheral Blood Leucocytes In Vitro Studied by Electron Microscopy
Dupont, Aurélie; De Pauw-Gillet, Marie-Claire ULg; Schnitzler, Joseph ULg et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 133-142

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal ... [more ▼]

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal lymphocytes, ConA-stimulated peripheral blood leucocytes were exposed in vitro to sub-lethal concentrations of MeHgCl (0.2, 1 and 2 µM) for 72h, and then analysed for their viability and ultrastructure. After 72h of incubation, cells were counted with a propidium iodide staining technique, a metabolic MTS assay was performed, and cells exposed to 1 µM MeHgCl were observed by transmission electron microscopy (TEM). Alive cell numbers decreased with increased MeHgCl concentrations. In presence of ConA and 1µM of MeHgCl, TEM images revealed a higher frequency of apoptotic cells. Exposed cells displayed condensation of the chromatin at the nuclear membrane and mitochondrial damages. The results suggest that in vitro MeHgCl induced apoptosis in harbour seal lymphocytes through a mitochondrial pathway. [less ▲]

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See detailLater learning stages in procedural memory are impaired in children with Specific Language Impairment
Desmottes, Lise ULg; Meulemans, Thierry ULg; Maillart, Christelle ULg

in Research in Developmental Disabilities (2016)

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language ... [more ▼]

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language Impairment (SLI). Most studies investigating the PDH have used the sequence learning paradigm; however these studies have principally focused on initial sequence learning in a single practice session. Aims The present study sought to extend these investigations by assessing the consolidation stage and longer-term retention of implicit sequence-specific knowledge in 42 children with or without SLI. Methods and procedures Both groups of children completed a serial reaction time task and were tested 24 h and one week after practice. Outcomes and results Results showed that children with SLI succeeded as well as children with typical development (TD) in the early acquisition stage of the sequence learning task. However, as training blocks progressed, only TD children improved their sequence knowledge while children with SLI did not appear to evolve any more. Moreover, children with SLI showed a lack of the consolidation gains in sequence knowledge displayed by the TD children. Conclusions and implications Overall, these results were in line with the predictions of the PDH and suggest that later learning stages in procedural memory are impaired in SLI. [less ▲]

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See detailPopulatieonderzoek naar de Hazelmuis in de Voerstreek
Verbeylen, Goedele; Mouton, Alice ULg; Driessens, Gerald et al

in De Levende Natuur (2016), (numero 1),

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation ... [more ▼]

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation and fragmentation the Flemish distribution area of this critically endangered species has been reduced to the eastern part of the municipality of Voeren, where it forms a cross-border population with the Dutch Hazel dormice. Since 2003 the Mammal Working Group of Natuurpunt studies the remaining Flemish population to find out more about population parameters, habitat use, the influence of habitat quality and management actions. In 2007 a standardised monitoring started by counting autumnal nests along fixed transects. In 2013 an intensive capture-mark-recapture study was set up based on nest box and nest tube checks and live-trapping on custom made hanging platforms; also a first test with radiocollars took place. The information gathered from the combination of all these methods will be used to validate the monitoring method and to formulate better protection measures. First results show that late summer and autumn should not be considered as the main reproduction period, at least not in an early year like 2014 when first young were already born at the beginning of May. Hazel dormice do not only cross significant barriers like the railway during dispersal, but also do this regularly during their nightly movements within their home range. Expansion of the population on a location with sufficient connectivity seems to be hampered by a too low population density resulting from insufficient habitat quality and (in this case) a high predation pressure by house cats. On the scale of the Meuse-Rhine Euregion, genetic analyses carried out by the University of Liège reveal four genetically isolated clusters, for which a vision to interconnect these was computed in the Interreg-project ‘Habitat Euregio’. [less ▲]

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See detailDynamical thermalization in Bose-Hubbard systems
Schlagheck, Peter ULg; Shepelyansky, Dima L.

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016), 93

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions ... [more ▼]

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions induce dynamical thermalization in this isolated system. In this regime the individual many-body eigenstates are well described by the standard thermal Bose-Einstein distribution for well-defined values of the temperature and the chemical potential, which depend on the eigenstate under consideration. We show that the dynamical thermalization conjecture works well at both positive and negative temperatures. The relations to quantum chaos, quantum ergodicity, and the Åberg criterion are also discussed. [less ▲]

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See detailXenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects?
Lehnert, Kristina; Ronnenberg, Katrin; Weijs, Liesbeth et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 106-120

Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which ... [more ▼]

Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect the immune-system and have been reported e.g. to increase susceptibility to viral infections in seals. Biomarkers of the xenobiotic metabolism, cytokines and heat-shock-protein as cell mediators of the immune-system were established to evaluate the impact of environmental stressors on harbor seals. Harbor seals (n=54) were captured on sandbanks in the North Sea during 2009 to 2012. Medicals including hematology were performed, RNAlater blood samples were taken and analyzed using quantitative Polymerase Chain Reaction. Normalized transcript copy numbers were correlated to hematology and POP concentration in blood, and trace metals in blood and fur. [less ▲]

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See detailDoes the Budyko curve reflect a maximum power state of hydrological systems? A backward analysis
Westhoff, Martijn ULg; Zehe, Erwin; Archambeau, Pierre ULg et al

in Hydrology and Earth System Sciences (2016), 20

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we ... [more ▼]

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we applied the thermodynamic principle of maximum power as the organizing principle. In a top-down approach we derived mathematical formulations of the relation between relative wetness and gradients driving runoff and evaporation for a simple one-box model. We did this in an inverse manner such that when the conductances are optimized with the maximum power principle, the steady state behaviour of the model leads exactly to a point on the asymptotes of the Budyko curve. Subsequently, we added dynamics in forcing and actual evaporations, causing the Budyko curve to deviate from the asymptotes. Despite the simplicity of the model, catchment observations compare reasonably well with the Budyko curves subject to observed dynamics in rainfall and actual evaporation. Thus by constraining the model with the asymptotes of the Budyko curve we were able to derive more realistic values of the aridity and evaporation index without any calibration parameter. Future work should focus on better representing the boundary conditions of real catchments and eventually adding more complexity to the model. [less ▲]

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See detailL'intentionnalité cognitive et ses modes. Reinach critique de Brentano
Dewalque, Arnaud ULg

in Philosophie (2016), 128

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai ... [more ▼]

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai mon attention sur certaines divergences significatives entre Reinach et Brentano. Après quelques réflexions introductives (§§ 1-2), j’examinerai plus exactement les questions suivantes : quels sont les motifs théoriques qui ont conduit Reinach à s’écarter de la théorie brentanienne du jugement (§§ 3-4) ? Et que retenir de ses analyses aujourd’hui (§§ 5-6) ? [less ▲]

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See detailGender differences in variability and extreme scores in an international context
Baye, Ariane ULg; Monseur, Christian ULg

in Large-scale Assessments in Education (2016), 4(1),

This study examines gender differences in the variability of student performance in reading, mathematics and science. Twelve databases from IEA and PISA were used to analyze gender differences within an ... [more ▼]

This study examines gender differences in the variability of student performance in reading, mathematics and science. Twelve databases from IEA and PISA were used to analyze gender differences within an international perspective from 1995 to 2015. Effect sizes and variance ratios were computed. The main results are as follows. (1) Gender differences vary by content area, students’ educational levels, and students’ proficiency levels. The gender differences at the extreme tails of the distribution are often more substantial than the gender differences at the mean. (2) Exploring the extreme tails of the distributions shows that the situation of the weakest males in reading is a real matter of concern. In mathematics and science, males are more frequently among the highest performing students. (3) The “greater male variability hypothesis” is confirmed. [less ▲]

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See detailFlexible estimation in cure survival models using Bayesian P-splines
Bremhorst, Vincent; Lambert, Philippe ULg

in Computational Statistics & Data Analysis (2016), 93

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an ... [more ▼]

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N independent latent event times with a common distribution independent of N. An extension which allows the covariates to influence simultane- ously the probability of being cured and the latent distribution is presented. The latent distribution is estimated using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of P- splines provides a smooth estimation of the population hazard ratio over time. The identification issues of the model are discussed and a restricted use of the model when the follow up of the study is not sufficiently long is proposed. The accuracy of our methodology is evaluated through a simulation study and the model is illustrated on data from a Melanoma clinical trial. [less ▲]

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See detailFirst-Principles Study of the Thermoelectric Properties of SrRuO3
Miao, Naihua; Xu, Bin ULg; Bristowe, Nicholas ULg et al

in Journal of Physical Chemistry (2016), 120

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See detailThe Robust Economic Statistical Design of the Hotelling’s T^2 Chart
Faraz, Alireza ULg; Chalaki, Kamyar; Saniga, Erwin et al

in Communications in Statistics : Theory & Methods (2016)

Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the ... [more ▼]

Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the process may be affected by more than one scenario which may lead to severe cost penalties for upsetting the true scenario. This paper presents the robust economic statistical design (RESD) of the T^2 chart to reduce the monetary losses when there are multiple distinct scenarios. The genetic algorithm optimization method is employed here to minimize the total expected monitoring cost across all distinct scenarios. Through two numerical examples the proposed method is illustrated. Simulation studies indicate that the robust economic statistical designs should be encouraged in practice. [less ▲]

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See detailRecording and Reading Alchemy and Art-Technology in Medieval and Premodern German Recipe Collections
Neven, Sylvie ULg

in Nuncius. Journal of the Material and Visual History of Science (2016)

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See detailQuadratization of symmetric pseudo-Boolean functions
Anthony, Martin; Boros, Endre; Crama, Yves ULg et al

in Discrete Applied Mathematics (2016), 203

A pseudo-Boolean function is a real-valued function $f(x)=f(x_1,x_2,\ldots,x_n)$ of $n$ binary variables; that is, a mapping from $\{0,1\}^n$ to ${\bbr}$. For a pseudo-Boolean function $f(x)$ on $\{0,1 ... [more ▼]

A pseudo-Boolean function is a real-valued function $f(x)=f(x_1,x_2,\ldots,x_n)$ of $n$ binary variables; that is, a mapping from $\{0,1\}^n$ to ${\bbr}$. For a pseudo-Boolean function $f(x)$ on $\{0,1\}^n$, we say that $g(x,y)$ is a quadratization of $f$ if $g(x,y)$ is a Quadratic polynomial depending on $x$ and on $m$ auxiliary binary variables $y_1,y_2,\ldots,y_m$ such that $f(x)= \min \{ g(x,y) : y \in \{0,1\}^m \} $ for all $x \in \{0,1\}^n$. By means of quadratizations, minimization of $f$ is reduced to minimization (over its extended set of variables) of the quadratic function $g(x,y)$. This is of some practical interest because minimization of quadratic functions has been thoroughly studied for the last few decades, and much progress has been made in solving such problems exactly or heuristically. A related paper initiated a systematic study of the minimum number of auxiliary $y$-variables required in a quadratization of an arbitrary function $f$ (a natural question, since the complexity of minimizing the quadratic function $g(x,y)$ depends, among other factors, on the number of binary variables). In this paper, we determine more precisely the number of auxiliary variables required by quadratizations of \emph{symmetric} pseudo-Boolean functions $f(x)$, those functions whose value depends only on the Hamming weight of the input $x$ (the number of variables equal to 1). [less ▲]

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See detailInvestigational insulin secretagogues for type 2 diabetes.
SCHEEN, André ULg

in Expert opinion on investigational drugs (2016), 25(4), 405-22

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent ... [more ▼]

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent of glucose and cause hypoglycemia. Despite the advantages offered by incretin-based therapies, there is still a medical need for developing new insulin secretagogues for treating T2D. AREA COVERED: This article discusses: the new advances in the field of incretin-based therapies, glucokinase (GK) activators, free fatty acid receptor (FFAR) or G protein-coupled receptor (GPR) agonists (GPR40, GPR119, GPR120), imeglimin and some other insulin secretagogues with diverse mechanisms of action still in preclinical development. EXPERT OPINION: New insulin secretagogues should offer major advantages over sulfonylureas and gliptins. The challenge is to avoid uncontrolled insulin secretion and minimize the risk of hypoglycemia, to protect cells from progressive loss of mass and function for a better durability of glucose control, and to offer a good safety profile. Numerous approaches are in development. However, it is too early to decide whether one new pharmacological class will emerge as a clinically useful insulin secretagogue in the near feature. [less ▲]

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See detailDispositif en ligne d’entraînement à la résolution de problèmes de physique
Marique, Pierre-Xavier ULg; Jacquet, Maud ULg; Georges, François ULg et al

in RDST - Recherches en Didactique des Sciences et des Technologies (2016)

As part of projects aiming to reduce failure during bachelor studies, LabSET and physics teachers of the university of Liège developed an online package designed to improve skills in solving physics ... [more ▼]

As part of projects aiming to reduce failure during bachelor studies, LabSET and physics teachers of the university of Liège developed an online package designed to improve skills in solving physics problems. Research focuses, on one hand, on diagnosis as to whether cognitive processes used in solving physics problems are mastered by the user or not and, on the other hand, on the link between effective online training and students performance at solving examination problems. Analyses rely on a 1 study conducted with 876 first-year medicine students. They were performed on the basis of subjective (self-evaluation of process and product) and objective (number of connections, results on specific questions for each cognitive process, passing rate and examination results) data. At the end of the research, we observed that the analysis process is the one for which the students show most difficulties. Almost 50 % of the students are aware of this. Although the strength of association is weak to medium, dependence is observed between online work and success at solving the examination problems. The results of students who worked online are higher than those of students who did not. However, considering that students who passed the physics examination also passed the examinations on other scientific subjects, it is difficult to establish a causality link between online work and performance. [less ▲]

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See detailQuantification of paravalvular regurgitation after transcatheter aortic valve implantation: improved accuracy means better standardization.
Lancellotti, Patrizio ULg; Piazza, Nicolo; Modine, Thomas

in European Heart Journal - Cardiovascular Imaging (2016)

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See detailThe role of active site flexible loops in catalysis and of zinc in conformational stability of Bacillus cereus 569/H/9 beta-lactamase.
Montagner, Caroline ULg; Nigen, Michaël; Jacquin, Olivier et al

in Journal of Biological Chemistry (2016)

Metallo-beta-lactamases catalyse the hydrolysis of most beta-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for these enzymes is complicated by the ... [more ▼]

Metallo-beta-lactamases catalyse the hydrolysis of most beta-lactam antibiotics and hence represent a major clinical concern. The development of inhibitors for these enzymes is complicated by the diversity and flexibility of their substrate binding sites, motivating research into their structure and function. In this study, we examined the conformational properties of the Bacillus cereus beta-lactamase II in the presence of chemical denaturants using a variety of biochemical and biophysical techniques. The apoenzyme was found to unfold cooperatively, with a Gibbs free energy of stabilization (DeltaG degrees ) of 32 +/- 2 kJ.mol11. For holoBcII, a first non-cooperative transition leads to multiple interconverting native-like states, in which both zinc atoms remain bound in an apparently unaltered active site and the protein displays a well-organized compact hydrophobic core with structural changes confined to the enzyme surface, but with no catalytic activity. 2D NMR data revealed that the loss of activity occurs concomitantly with perturbations in two loops that border the enzyme active site. A second cooperative transition, corresponding to global unfolding, is observed at higher denaturant concentrations, with DeltaG degrees value of 65 +/- 1.4 kJ.mol11. These combined data highlight the importance of the two zinc ions in maintaining structure as well as a relatively well-defined conformation for both active site loops in order to maintain enzymatic activity. [less ▲]

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See detailDes situations-limites au dépassement de la situation : phénoménologie d'un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

in Sartre Studies International (2016), 22(1), 99-116

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant ... [more ▼]

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant. Notre approche se fonde sur un double mouvement : d’une part, une archéologie du concept dans le contexte de la première percée de la phénoménologie en France dans les années 1930 ; d’autre part, une attention à son possible dépassement deux décennies plus tard. Dans une relation serrée avec les développements de la psychopathologie de son temps, il s’agit d’abord de situer la prétention de l’Esquisse d’une théorie des émotions à poser les bases d’une phénoménologie de « l’homme en situation », ensuite d’éclairer la reprise critique du concept dans Questions de méthode, dans l’exposition de la méthode progressive-régressive. En somme, il s’agit de montrer comment s’élabore progressivement chez Sartre une « herméneutique de l’existence » qui fait droit à la liberté, puis se donne les moyens d’en suivre l’action effective dans le monde. [less ▲]

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See detailNociceptive and sympathetic innervations in the abaxial part of the cranial horn of the equine medial meniscus: an immunohistochemical approach
Nemery, Elodie ULg; Gabriel, Annick ULg; Piret, Joëlle ULg et al

in Journal of Anatomy (2016)

In athletic horses, diseases leading to lameness are of major importance due to the loss of performance and the resultant economic concerns. Although, in the hindlimb, stifle lesions are frequent due to ... [more ▼]

In athletic horses, diseases leading to lameness are of major importance due to the loss of performance and the resultant economic concerns. Although, in the hindlimb, stifle lesions are frequent due to the large and complex joint, and meniscal tears have been identified as the most common soft tissue injuries in this joint, little is known about the mechanism that causes the painful sensation and thus the lameness. The aim of our study was therefore to highlight any peripheral fibres involved in meniscal nociception in five healthy anterior horns of the equine medial meniscus, which is the most common locale reported for equine meniscal injuries. Immunohistochemical stainings were performed using antibodies against Substance P in order to identify nociceptive fibres; antibodies against tyrosine hydroxylase for detecting postganglionic sympathetic fibres; and against glial fibrillary acidic proteins in order to identify Schwann cells. Fundamentally, our work highlights for the first time the presence of nociceptive and sympathetic fibres in equine menisci. They were found in the abaxial part of the anterior horn of the equine medial meniscus. This study suggests thus that when the abaxial part is injured, the meniscus itself could be the source of pain. This finding provides a better understanding of the nociceptive and sympathetic innervation of the equine meniscus which could contribute towards improving the therapeutic strategies in order to alleviate pain in cases of equine meniscal injury. [less ▲]

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See detailFree public transport: A socio-cognitive analysis
Cools, Mario ULg; Fabbro, Yannick; Bellemans, Tom

in Transportation Research. Part A : Policy & Practice (2016), 86

In this study, the modal shift potential of introducing a free alternative (free public transportation) and of changing the relative prices of transportation is examined. The influence of a cognitive ... [more ▼]

In this study, the modal shift potential of introducing a free alternative (free public transportation) and of changing the relative prices of transportation is examined. The influence of a cognitive analysis on the zero-price effect is also analyzed. The data used for the analysis stem from a stated preference survey with a sample of approximately 670 respondents that was conducted in Flanders, Belgium. The data are analyzed using a mixed logit model. The modeling results yield findings that confirm the existence of a zero-price effect in transport, which is in line with the literature. This zero-price effect is increased by the forced cognitive analysis for shopping trips, although not for work/school or recreational trips. The results also demonstrate the importance of the current mode choice in hypothetical mode choices and the importance of car availability. The influence of changing relative prices on the modal shift is found to be insignificant. This might be partially because the price differences were too small to matter. Hence, an increase in public transport use can be facilitated by the introduction of free public transport, particularly when individuals evaluate the different alternatives in a more cognitive manner. These findings should be useful to policy makers evaluating free public transport and considering how best to target and promote relevant policy. [less ▲]

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See detailContinuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Di Marco, Lorenzo; Hans, Morgan; Delaude, Lionel ULg et al

in Chemistry : A European Journal (2016), 22

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a ... [more ▼]

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homoge¬neous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions, namely, the transesterification of vinyl acetate with benzyl alcohol and the amidation of N-Boc-glycine methyl ester with ethanolamine. Both organocatalytic transfor¬ma¬tions proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs. [less ▲]

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See detailTransatlantic editorial: A comparison between European and North American guidelines on myocardial revascularization.
Kolh, Philippe ULg; Kurlansky, Paul; Cremer, Jochen et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2016)

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See detailIsolation and characterization of Ts19 Fragment II, a new long-chainpotassium channel toxin from Tityus serrulatus venom
Cerni, Felipe Augusto; Pucca, Manuela Berto; Amorim, Fernanda Gobbi et al

in Peptides (2016), 80

Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was ... [more ▼]

Ts19 Fragment II (Ts19 Frag-II) was first isolated from the venom of the scorpion Tityus serrulatus (Ts). It is aprotein presenting 49 amino acid residues, three disulfide bridges, Mr5534 Da and was classified as a newmember of class (subfamily) 2 of the -KTxs, the second one described for Ts scorpion. The -KTx familyis composed by two-domain peptides: N-terminal helical domain (NHD), with cytolytic activity, and aC-terminal CS domain (CCD), with Kv blocking activity. The extensive electrophysiological screening(16 Kv channels and 5 Nav channels) showed that Ts19 Frag-II presents a specific and significant blockingeffect on Kv1.2 (IC50value of 544 ± 32 nM). However, no cytolytic activity was observed with this toxin.We conclude that the absence of 9 amino acid residues from the N-terminal sequence (compared to Ts19Frag-I) is responsible for the absence of cytolytic activity. In order to prove this hypothesis, we synthesizedthe peptide with these 9 amino acid residues, called Ts19 Frag-III. As expected, Ts19 Frag-III showed tobe cytolytic and did not block the Kv1.2 channel. The post-translational modifications of Ts19 and itsfragments (I–III) are also discussed here. A mechanism of post-translational processing (post-splitting) issuggested to explain Ts19 fragments production. In addition to the discovery of this new toxin, this reportprovides further evidence for the existence of several compounds in the scorpion venom contributing tothe diversity of the venom arsenal. [less ▲]

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See detailA systematic review of geological evidence for Holocene earthquakes and tsunamis along the Nankai-Suruga Trough, Japan
Garrett, Ed; Fujiwara, Osamu; Garrett, Philip et al

in Earth-Science Reviews (2016)

The Nankai-Suruga Trough, the subduction zone that lies immediately south of Japan’s densely populated southern coastline, generates devastating great earthquakes (magnitude > 8) characterised by intense ... [more ▼]

The Nankai-Suruga Trough, the subduction zone that lies immediately south of Japan’s densely populated southern coastline, generates devastating great earthquakes (magnitude > 8) characterised by intense shaking, crustal deformation and tsunami generation. Forecasting the hazards associated with future earthquakes along this >700 km long fault requires a comprehensive understanding of past fault behaviour. While the region benefits from a long and detailed historical record, palaeoseismology has the potential to provide a longer-term perspective and additional crucial insights. In this paper, we summarise the current state of knowledge regarding geological evidence for past earthquakes and tsunamis along the Nankai-Suruga Trough. Incorporating literature originally published in both Japanese and English and enhancing available results with new age modelling approaches, we summarise and critically evaluate evidence from a wide variety of sources. Palaeoseismic evidence includes uplifted marine terraces and biota, marine and lacustrine turbidites, liquefaction features, subsided marshes and tsunami deposits in coastal lakes and lowlands. While 75 publications describe proposed evidence from more than 70 sites, only a limited number provide compelling, well-dated evidence. The best available records enable us to map the most likely rupture zones of twelve earthquakes occurring during the historical period. This spatiotemporal compilation suggests the AD 1707 earthquake ruptured almost the full length of the subduction zone and that earthquakes in AD 1361 and 684 may have been predecessors of similar magnitude. Intervening earthquakes were of lesser magnitude, highlighting the variability in rupture mode that characterises the Nankai-Suruga Trough. Recurrence intervals for ruptures of the same seismic segment range from less than 100 to more than 450 years during the historical period. Over longer timescales, palaeoseismic evidence suggests intervals between earthquakes ranging from 100 to 700 years, however these figures reflect a range of thresholds controlling the of creation and preservation of evidence at any given site as well as genuine earthquake recurrence intervals. At present, there is no geological data that suggest the occurrence of a larger magnitude earthquake than that experienced in AD 1707, however few studies have sought to establish the relative magnitudes of different earthquake and tsunami events along the Nankai-Suruga Trough. Alongside the lack of research designed to quantify the maximum magnitude of past earthquakes, we emphasise issues over alternative hypotheses for proposed palaeoseismic evidence, the paucity of robust chronological frameworks and insufficient appreciation of changing thresholds of evidence creation and preservation over time as key issues that must be addressed by future research. [less ▲]

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See detailCOMPARISON OF ULTRASOUND-GUIDED VS. STANDARD LANDMARK TECHNIQUES FOR TRAINING NOVICE OPERATORS IN PLACING NEEDLES INTO THE LUMBAR SUBARACHNOID SPACE OF CANINE CADAVERS
Etienne, Anne-Laure ULg; Delguste, Catherine ULg; Busoni, Valeria ULg

in Veterinary Radiology & Ultrasound (2016)

The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this ... [more ▼]

The standard technique for placing a needle into the canine lumbar subarachnoid space is primarily based on palpation of anatomic landmarks and use of probing movements of the needle, however, this technique can be challenging for novice operators. The aim of the current observational, prospective, ex vivo, feasibility study was to compare ultrasound-guided vs. standard anatomic landmark approaches for novices performing needle placement into the lumbar subarachnoid space using dog cadavers. Eight experienced operators validated the canine cadaver model as usable for training landmark and ultrasound-guided needle placement into the lumbar subarachnoid space based on realistic anatomy and tissue consistency. With informed consent, 67 final year veterinary students were prospectively enrolled in the study. Students had no prior experience in needle placement into the lumbar subarachnoid space or use of ultrasound. Each student received a short theoretical training about each technique before the trial and then attempted blind landmark-guided and ultrasound-guided techniques on randomized canine cadavers. After having performed both procedures, the operators completed a self-evaluation questionnaire about their performance and self-confidence. Total success rates for students were 48% and 77% for the landmark- and ultrasound-guided techniques, respectively. Ultrasound guidance significantly increased total success rate when compared to the landmark-guided technique and significantly reduced the number of attempts. With ultrasound guidance self-confidence was improved, without bringing any significant change in duration of the needle placement procedure. Findings indicated that use of ultrasound guidance and cadavers are feasible methods for training novice operators in needle placement into the canine lumbar subarachnoid space. [less ▲]

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See detailCompte rendu de Christophe CHANDEZON, Julien DU BOUCHET (éds.), Artémidore de Daldis et l’interprétation des rêves. Quatorze études
Berg, Tatiana ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2016), 85

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See detailLa pensée future épisodique : entre simulation et contexte autobiographique
D'Argembeau, Arnaud ULg

in Revue de Neuropsychologie (2016), 8

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See detailIs adult translocation a credible way to accelerate the recolonization process of Chondrostoma nasus in a rehabilitated river?
Ovidio, Michaël ULg; Hanzen, Céline; Gennotte, Vincent ULg et al

in Cybium (2016), 40(1), 43-49

The decline of the patrimonial rheophilic nase, Chondrostoma nasus (Linnaeus, 1758) populations was mainly caused by construction of dams and hydroelectric power-plants, together with the straightening ... [more ▼]

The decline of the patrimonial rheophilic nase, Chondrostoma nasus (Linnaeus, 1758) populations was mainly caused by construction of dams and hydroelectric power-plants, together with the straightening and artificialization of the river banks and water pollution. In this study, we tested the hypothesis whether the translocation of few adult nase individuals from a river stretch to another upstream may be a credible way to accelerate the recolonization process of the species in the Amblève River (Southern Belgium). In February and March 2011, just before their spawning period, eight adult nases (462-509 mm; 1546-2002 g; presumed males and females) were captured in the lower part of the River Amblève. Fin clip samples were stored in alcohol for further genetic analysis. They were equipped with a 14 g radio transmitter and translocated upstream in a 18 km river stretch, where the species had disappeared since decades due to river anthropization. They were manually located two to five times/week using mobile receivers until maximum June 2012 (n = 977 locations). River temperature and flow were hourly recorded during the entire tracking period. The tagged nase individuals displayed various mobility patterns, exploited different areas of the river stretch, occupied longitudinal home ranges from 3.4 to 36.1 km (one individual finally left the new river stretch) and travelled total distances from 12.2 to 186.6 km. The tagged individuals were most of the times apart from one to another, but most individuals grouped together in potential spawning areas in late March-early April 2011, suggesting an attempt to reproduce. In September 2011, electric fishing in two potential detected spawning sites allowed to capture 16 juvenile (0+) nases, demonstrating the existence of spawning activity in the newly occupied river stretch. Individual genetic characterization was performed in 2014 in order to reveal a possible direct lineage between juveniles and adults. Allelic distribution of 22 microsatellite markers unambiguously identified the 16 juveniles as full-sib progeny descending from two of the translocated adults. This demonstrated that the adult nases succeeded to find spawning areas and that progeny found raised-up from the translocated individuals. [less ▲]

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See detailRecommendations for the imaging assessment of prosthetic heart valves: a report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging.
Lancellotti, Patrizio ULg; Pibarot, Philippe; Chambers, John et al

in European heart journal cardiovascular Imaging (2016)

Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate ... [more ▼]

Prosthetic heart valve (PHV) dysfunction is rare but potentially life-threatening. Although often challenging, establishing the exact cause of PHV dysfunction is essential to determine the appropriate treatment strategy. In clinical practice, a comprehensive approach that integrates several parameters of valve morphology and function assessed with 2D/3D transthoracic and transoesophageal echocardiography is a key to appropriately detect and quantitate PHV dysfunction. Cinefluoroscopy, multidetector computed tomography, cardiac magnetic resonance imaging, and to a lesser extent, nuclear imaging are complementary tools for the diagnosis and management of PHV complications. The present document provides recommendations for the use of multimodality imaging in the assessment of PHVs. [less ▲]

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See detailLes catégories au seuil de la phénoménologie
Gauvry, Charlotte ULg; Fagniez, Guillaume

in Etudes Philosophiques (Les) (2016)

Le tournant du XXe siècle est marqué par un retour de la problématique catégoriale sur le devant de la scène philosophique, que ce soit chez Franz Brentano et ses élèves, chez Wilhelm Dilthey, chez les ... [more ▼]

Le tournant du XXe siècle est marqué par un retour de la problématique catégoriale sur le devant de la scène philosophique, que ce soit chez Franz Brentano et ses élèves, chez Wilhelm Dilthey, chez les Néokantiens de l’école de Bade, ou chez les premiers pionniers de la phénoménologie. Tant et si bien qu’une certaine philosophie (celle d’Emil Lask par excellence) a pu se présenter comme une doctrine des catégories à part entière. L’enjeu de ce numéro est d’interroger la place historique et le rôle conceptuel qu’ont joué ces questions formelles dans l’émergence de la phénoménologie. Kant avait certes renoué avec la question aristotélicienne des catégories pour postuler l’existence de « purs concepts de l’entendement » ou « catégories », seuls susceptibles de « fournir de l’unité aux diverses représentations dans un jugement et [de] donner aussi à la simple synthèse de diverses représentations dans une intuition une unité » (KRV, §10). L’intérêt proto-phénoménologique pour les catégories se présente-t-il cependant comme un retour, par-delà l’idéalisme allemand, à cette problématique transcendantale kantienne ou bien plutôt comme un retour, par-delà Kant lui-même, à la question aristotélicienne ? Si les philosophes du début XXe se sont ressaisis de la question des catégories, il semble qu’ils aient à tout le moins reformulé, voire abandonné la méthode de la « déduction ». C’est ce travail de reformulation de la déduction transcendantale que le numéro entend également clarifier. Peut-on encore dire que ces catégories sont « déduites » des formes logiques du jugement, des objets logiques ou du mouvement même de la vie ? S’il y a lieu de mettre au jour un processus « génétique » de la catégorie, quelles sont les implications d’un tel déplacement relativement à la validité du catégorial ? Plus généralement, c’est le statut même de ces « catégories » qui sera analysé. Leur domaine d’application redéfini, peut-on les déterminer comme des concepts purs transcendantaux susceptibles d’unifier l’expérience sensible ? Les catégories ne doivent-elles pas plutôt être repensées comme des formes logiques, sémantiques ou même ontologiques ? Ainsi, c’est l’enjeu stratégique de la résurgence de cette problématique catégoriale, et ses répercussions directes sur l’émergence de la phénoménologie naissante (husserlienne et heideggérienne) que ce numéro interrogera. [less ▲]

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See detailSeasonal Variation of Harbor Seal's Diet from the Wadden Sea in Relation to Prey Availability
de la Vega, Camille; Lebreton, Benoit; Siebert, Ursula et al

in PLoS ONE (2016)

The Wadden Sea has an important role for marine mammals in terms of resting, nursing and foraging. Harbor seal is the most abundant marine mammal species in this area. The use of the food resources of the ... [more ▼]

The Wadden Sea has an important role for marine mammals in terms of resting, nursing and foraging. Harbor seal is the most abundant marine mammal species in this area. The use of the food resources of the Wadden Sea by seals is not clear, and previous studies showed that this species can travel kilometers away from their haul-outs to forage in the North Sea. In this study, we analyzed the stable isotopes of vibrissae from 23 dead harbor seals found on the island of Sylt to investigate their diet. The predator´s carbon and nitrogen isotope compositions were compared to the compositions of different potential prey items from the Sylt-Rømø Bight and from the North Sea in order to study seasonal pattern in the diet and in the foraging location. In parallel, seasonal variation of abundance and biomass of the potential prey items from the Sylt-Rømø Bight were studied and compare to their contribution to the seal´s diet. The results revealed a change in the seal´s diet from pelagic sources in spring to a benthic based diet in summer, and an increasing use of the North Sea resources in fall and winter in accordance with the seasonal variation of the availability of prey in the Sylt-Rømø Bight. [less ▲]

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See detailLarge-Eddy Simulations of microcarrier exposure to potentially damaging eddies inside mini-bioreactors
Collignon, Marie-Laure ULg; Delafosse, Angélique; Calvo, Sébastien ULg et al

in Biochemical Engineering Journal (2016)

Mechanically stirred vessels equipped with rotating impellers generate heterogeneous transitional or turbulent flows. However, some cells as animal or human mesenchymal stem cells (hMSC) adhered on ... [more ▼]

Mechanically stirred vessels equipped with rotating impellers generate heterogeneous transitional or turbulent flows. However, some cells as animal or human mesenchymal stem cells (hMSC) adhered on microcarriers, are reputed sensitive to hydromechanical stresses arising from stirring. Many publications, especially using Computational Fluid Dynamics, characterize spatial fields of velocity and turbulence inside bioreactors but the exposure frequency to these stresses is never taken into account in the case of animal cell culture bioreactor description. To fill this gap, this study used both CFD Reynolds-Averaged and Large-Eddy Simulations to characterize the hydrodynamics inside 250 mL mini-bioreactors, which is a relevant volume for hMSC cultures. Five impeller geometries were studied. From the velocity and turbulence fields calculated, an energy dissipation/circulation function, related to both frequency and intensity of potentially damaging hydrodynamic events for the cells, was determined for various operating conditions. Based on the simulation results, the marine propeller operating in up-pumping mode seems to be the most adapted condition, since it exhibits a low frequency of exposure to an acceptable intensity of the turbulent dissipation rate. From a general point of view, the new methodology proposed should be used in the future to screen the most adapted bioreactor geometry to biological constraints. [less ▲]

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See detailL’impact des activités non agricoles sur la pauvreté et l’inégalité rurales dans les groupements Bugorhe et Irhambi-Katana (Territoire de Kabare, Province du Sud-Kivu)
Furaha Mirindi, Germaine ULg; Namegabe Mastaki, Jean Luc; Lebailly, Philippe ULg

in JOURNAL OF ORIENTAL AND AFRICAN STUDIES (2016), 25

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of ... [more ▼]

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of Congo, by comparing a group of households practicing agriculture only and another group which combines agriculture and nonfarm activities. The approach used considers non farm income as an exogenous transfer which completes the whole household income, and analyses the contribution of different sources of income on the inequality in using the Gini index. The results show that inequality increases when a segment of the population does not have access to non-agricultural income. In this case, non farm income is not a substitute of farm income, rather the complement. The poverty analysis is based on the Congolese rural threshold poverty in terms of basic needs to calculate the rate, depth and severity of poverty indexes in using of Foster- Greer-Thorbecke. The results show that households practicing agriculture only are poorer. [less ▲]

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See detailwicking through a confined micropillar array
Darbois-Texier, Baptiste ULg; Laurent, Philippe ULg; Stoukatch, Serguei ULg et al

in Microfluidics and Nanofluidics (2016), 20

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See detailDetermination of total phenolic compounds content and antioxidant activity in cherry species and cultivars
Pissard, Audrey; Lateur, Marc; Baeten, V et al

in Journal of Berry Research (2016)

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound ... [more ▼]

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound (TPC) content and the antioxidant capacity (AC) of a large range of cultivars using the same methodology in one laboratory, and (ii) determine the possible relationship between agronomic characteristics and AC. METHODS: A total of 245 samples including sweet, sour and hybrid cultivars from our collections were harvested at their optimum maturity and characterized according to their TPC, DPPH and ORAC values. RESULTS: The TPC content and DPPH and ORAC values varied greatly among the cherries, with the sour cultivars presenting higher levels than the sweet ones. The PCA plot showed a slight grouping by species and confirmed the high TPC content level in sour cultivars. The bi-colored cultivars had lower TPC and antioxidant capacity (AC) values than dark-colored ones, indicating that coloration could give an indication of the AC of fruits. No significant relationship between the agronomic and chemical properties was highlighted. CONCLUSIONS: Cherry fruits, especially from sour cultivars, represent an important source of bioactive compounds and could attract new interest as a ‘functional food’. [less ▲]

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See detailCombinaison fixe atorvastatine-ezetimibe (Atozet(R)).
Scheen, André ULg

in Revue medicale de Liege (2016), 71(1), 47-52

Cardiovascular prevention in subjects at high or very high risk requires a drastic reduction in LDL cholesterol according to the concept "the lower, the better". The combination of an inhibitor of ... [more ▼]

Cardiovascular prevention in subjects at high or very high risk requires a drastic reduction in LDL cholesterol according to the concept "the lower, the better". The combination of an inhibitor of cholesterol synthesis and a selective inhibitor of intestinal absorption results in a complementary and synergistic LDL-lowering activity. Besides a first fixed combination ezetimibe-simvastatin (Inegy(R)), a new fixed combination is presented, Atozet(R) that combines atorvastatin and ezetimibe. Because atorvastatin is more potent than simvastatin, this novel fixed combination should facilitate reaching therapeutic goals in terms of LDL cholesterol amongst patients with severe hypercholesterolaemia and/or at high or very high cardiovascular risk. [less ▲]

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See detailHDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies
Peixoto, Paul; Blomme, Arnaud; Costanza, Brunella ULg et al

in Oncogene (2016)

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 ... [more ▼]

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 patients and have identified a strong positive correlation between STAT3 and HDAC7 expression. In the current work we show the existence of a subpopulation of patients overexpressing HDAC7 and STAT3 that has particularly poor clinical outcome. Surprisingly, the somatic mutation rate of both STAT3 and HDAC7 was insignificant in GBM comparing with EGFR, PTEN or TP53. Depletion of HDAC7 in a range of GBM cells induced the expression of tyrosine kinase JAK1 and the tumor suppressor AKAP12. Both proteins synergistically sustained the activity of STAT3 by inducing its phosphorylation (JAK1) and protein expression (AKAP12). In absence of HDAC7, activated STAT3 was responsible for significant imbalance of secreted pro-/anti-angiogenic factors. This inhibited the migration and sprouting of endothelial cells in paracrine fashion in vitro as well as angiogenesis in vivo. In a murine model of GBM, induced HDAC7-silencing decreased the tumor burden by threefold. The current data show for the first time that silencing HDAC7 can reset the tumor suppressor activity of STAT3, independently of the EGFR/PTEN/TP53 background of the GBM. This effect could be exploited to overcome tumor heterogeneity and provide a new rationale behind the development of specific HDAC7 inhibitors for clinical use. [less ▲]

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See detailElectric Field Control of Jahn-Teller Distortions in Bulk Perovskites
Varignon, Julien ULg; Bristowe, Nicholas ULg; Ghosez, Philippe ULg

in Physical Review Letters (2016), 116

The Jahn-Teller distortion, by its very nature, is often at the heart of the various electronic properties displayed by perovskites and related materials. Despite the Jahn-Teller mode being nonpolar, we ... [more ▼]

The Jahn-Teller distortion, by its very nature, is often at the heart of the various electronic properties displayed by perovskites and related materials. Despite the Jahn-Teller mode being nonpolar, we devise and demonstrate, in the present Letter, an electric field control of Jahn-Teller distortions in bulk perovskites. The electric field control is enabled through an anharmonic lattice mode coupling between the Jahn-Teller distortion and a polar mode. We confirm this coupling and quantify it through first-principles calculations. The coupling will always exist within the Pb21m space group, which is found to be the favored ground state for various perovskites under sufficient tensile epitaxial strain. Intriguingly, the calculations reveal that this mechanism is not only restricted to Jahn-Teller active systems, promising a general route to tune or induce novel electronic functionality in perovskites as a whole. [less ▲]

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See detailLa gouvernance et le financement de l’enseignement supérieur: une approche microéconomique
Jacqmin, Julien ULg

in Reflets et Perspectives de la Vie Economique (2016), 2

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de ... [more ▼]

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de financement et de gouvernance auxquels font face les établissements de ce secteur. Premièrement, le lien entre le financement public du secteur et l’émergence de certains types d’institution est étudié. Ensuite, un modèle mettant en exergue le rôle de la composition du conseil d’administration est présenté. La dernière partie porte sur les conséquences d’une dérégulation des frais d’inscription. En conclusion, quelques aspects de l’enseignement supérieur en Fédération Wallonie-Bruxelles sont présentés à la lumière des différents points abordés. [less ▲]

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See detailMiddle Devonian Jawed polychate fauna from the type Eifel area, western Germany, and its biogeographical and evolutionary affinities
Tonarova, Petra; Hints, Olle; Könighsof, Peter et al

in Palaeontology (2016)

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See detailRole of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, Rayan; Vandenbosch, Renaud ULg; Omais, Saad et al

in Scientific Reports (2016)

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See detailQuasi-periodic injections of relativistic electrons in Saturn's outer magnetosphere
Roussos, E.; Krupp, N.; Mitchell, D. G. et al

in Icarus (2016), 263

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See detailInteractions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Nasir, Mehmet Nail ULg; Crowet, Jean-Marc ULg; Lins, Laurence ULg et al

in Biochimie (2016), In Press

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became ... [more ▼]

Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems. [less ▲]

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See detailCharacterization of almond kernel oils of five almonds varieties cultivated in Eastern Morocco
Houmy, Nadia; Mansouri, F.; Benmoumen, A. et al

in Cahiers Options Méditerranéennes (2016)

This study focuses on characterization of almondkernel oils extrated mechanically from five sweet almond varieties (Marcona, Fournat, Ferragnes, Ferraduel and Beldi), cultivated in eastern Morocco. Oil ... [more ▼]

This study focuses on characterization of almondkernel oils extrated mechanically from five sweet almond varieties (Marcona, Fournat, Ferragnes, Ferraduel and Beldi), cultivated in eastern Morocco. Oil content, physicochemical parameters, triacylglycerol and fatty acid compositions were determined. [less ▲]

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See detailLes exercices de contrôle moteur pour le traitement des lombalgies non-spécifiques aiguës
Demoulin, Christophe ULg

in Cochrane Database of Systematic Reviews (Online) (2016)

Traduction en Français du résumé de la revue

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See detailUnexpected LCST-type phase behaviour of a poly(vinyl thiazolium) polymer in acetone
Grygiel, Konrad; Zhang, Weiyi; Detrembleur, Christophe ULg et al

in RSC Advances (2016), 6(62), 57117-57121

We report on an unexpected lower critical solution temperature (LCST)-type phase transition of a poly(vinyl thiazolium) polymer in acetone solution, which was synthesized via radical polymerization of its ... [more ▼]

We report on an unexpected lower critical solution temperature (LCST)-type phase transition of a poly(vinyl thiazolium) polymer in acetone solution, which was synthesized via radical polymerization of its corresponding ionic monomer bearing no thermoresponsiveness in acetone. The phase transition temperature can be conveniently varied by polymer concentration, ionic strength and addition of a cosolvent. [less ▲]

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See detailFossil Biogeography: A new model to infer dispersal, extinction and sampling from paleontological data
Silvestro, Daniele; Zizka, Alexander; Bacon, Christine D. et al

in Philosophical Transactions : Biological Sciences (2016)

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See detailThe thyroid gland and thyroid hormones in sheepshead minnow (Cyprinodon variegatus) during early development and metamorphosis
Schnitzler, Joseph ULg; Klaren, Peter; Mariavelle, Emeline ULg et al

in Fish Physiology and Biochemistry (2016), 42(2), 607-616

The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However ... [more ▼]

The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However, reference levels of the thyroid prohormone thyroxine (T4) and biologically active hormone 3,5,30-triiodothyronine (T3) and their developmental patterns are unknown. This study set out to describe the ontogeny and morphology of the thyroid gland in sheepshead minnow, and to correlate these with whole-body concentrations of thyroid hormones during early development and metamorphosis. Eggs were collected by natural spawning in our laboratory. T4 and T3 were extracted from embryos, larvae and juveniles and an enzyme-linked immunoassay was used to measure whole-body hormone levels. Length and body mass, hatching success, gross morphology, thyroid hormone levels and histology were measured. The onset of metamorphosis at 12-day post-hatching coincided with surges in whole-body T4 and T3 concentrations. Thyroid follicles were first observed in pre-metamorphic larvae at hatching and were detected exclusively in the subpharyngeal region, surrounding the ventral aorta. Follicle size and thyrocyte epithelial cell heights varied during development, indicating fluctuations in thyroid hormone synthesis activity. The increase in the whole-body T3/T4 ratio was indicative of an increase in outer ring deiodination activity. This study establishes a baseline for thyroid hormones in sheepshead minnows, which will be useful for the understanding of thyroid hormone functions and in future studies of thyroid toxicants in this species. [less ▲]

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See detailMechanical behaviour of tape springs used in the deployment of reflectors around a solar panel
Dewalque, Florence ULg; Collette, Jean-Paul; Bruls, Olivier ULg

in Acta Astronautica (2016), 123

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this ... [more ▼]

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this work, reflectors are deployed by the means of compliant mechanisms known as tape springs. Their attractive characteristics are, among others, their passive behaviour, their self-locking capacity, their elastic deformations and their robustness. However, their mechanical behaviour is highly nonlinear and requires thorough analyses in order to develop predictive numerical models. It is shown here through parametric studies that the nonlinear behaviour of a tape spring is mainly governed by its geometry. Thus, for each specific application, its dimensions can be determined in order to minimise two critical features: the maximum stress affecting the structure and the maximum motion amplitude during deployment. In this paper, an optimisation procedure is proposed to meet these requirements. [less ▲]

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See detailEvaluation of a New Method for the Treatment of Invasive, Diffuse, and Unexcisable Lymphangiomas of the Oral Cavity with Defocus CO2 Laser Beam: A 20-Year Follow-Up
Namour, Samir ULg; VAN HEUSDEN, Alain ULg; Namour, Amaury et al

in Photomedicine and Laser Surgery (2016), 34(2), 82-87

Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and ... [more ▼]

Abstract Objective: The aim of our study is to evaluate the efficiency of a new therapeutic method using CO2 laser to avoid mutilation or total excision for the treatment of invasive, large and unexcisable oral lymphangiomas. Background data: Cystic lymphatic malformations, or lymphangiomas, are mature lymphatic malformations, consisting of abnormal lymphatic vessels. Surgical excision is considered by most surgeons to be the treatment of choice for lymphangioma. Laser beam has been used to treat superficial or small lymphatic malformations by excision or by photocoagulation, and to excise or photocoagulate small lymphangiomas. Patients and methods: Seventeen patients with diffuse and unexcisable lymphangiomas were treated using a CO2 laser with specific settings: beam was 2W in noncontact and defocus mode, power density was 0.63W/cm2 for irradiation time in the range of 3– 5min, and the estimated energy density range was 114.65–191.02 J/cm2. The beam diameter at the tissular impact point was –2 cm. The laser beam was defocused to provoke a deep heat generation that would dry up the lymphatic tissues and induce deep tissue necrosis that heals by fibrous tissue process. Results: The results were satisfactory and stable, with localized recurrence in three cases. The recurrent areas were re-treated using the same technique successfully and with no further recurrence. Conclusions: The use of CO2 laser under the suggested irradiation conditions can be considered a useful technique for the treatment of invasive lymphangiomas. [less ▲]

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See detail2015 ESC Guidelines for the management of infective endocarditis.
Habib, Gilbert; LANCELLOTTI, Patrizio ULg; Antunes, Manuel J. et al

in Revista espanola de cardiologia (English ed.) (2016), 69(1), 69

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See detailTrophic ecology of the seagrass-inhabiting footballer demoiselle Chrysiptera annulata (Peters, 1855); comparison with three other reef-associated damselfishes
Lepoint, Gilles ULg; Michel, Loïc ULg; Parmentier, Eric ULg et al

in Belgian Journal of Zoology (2016), 146(1), 21-32

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming ... [more ▼]

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming behavior, from almost non territorial to monoculture farmers. In addition, few species inhabit seagrass meadows but, presently, none can be considered as seagrass-eating specialists. The footballer demoiselle, Chrysiptera annulata, is found in the seagrass meadows on the reef flat of the Great Reef of Toliara (Madagascar, Mozambique Channel). Regarding this unusual habitat for pomacentrid, this study aimed to answer 3 questions: 1) What is the diet of C. annulata? 2) Do the resources supporting this diet include seagrass? 3) Does its trophic niche overlap those of other sympatric damselfishes (Pomacentrus trilineatus, Chrysiptera unimaculata and Plectroglyphidodon lacrymatus) living in close association with macrophytes or eating algae? Stomach content examination and stable isotope analysis showed that the footballer demoiselle is not a seagrass consumer but is an omnivorous/herbivorous species heavily relying on algal resources and small invertebrates. SIAR, a stable isotope mixing model, indicated it assimilated large amount of turf algae and various benthic or planktonic invertebrates in lower proportions. SIBER metrics pointed out that isotopic niche of the footballer demoiselle partly overlaps the one of its congeneric C. unimaculata, but not those of P. trilineatus and P. lacrymatus. Trophic strategies of C. annulata differed both from farming species such as P. lacrymatus or from less territorial herbivores such as P. trilineatus. Its seagrass meadow habitat on the Great Reef of Toliara allow the conquest of an unusual habitat for damselfishes and could limit competition with C. unimaculata, a species displaying the same territorial behavior and the same isotopic niche but living on the reef itself. [less ▲]

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See detailSolidarity economy and its anarchist grammar
Frère, Bruno ULg

in Sociology and anthropology (2016), 5(24),

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local ... [more ▼]

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local Exange Trading Systems, proximity services, organic community supported agriculture and fairtrade distributions. Because they try to answer to the Aristotelian theoretical question “what can we do to live harmoniously together?”, these solidarity initiatives are deeply political in the philosophical sense of the term. They galvanize civic commitment at the “micro” level. But today, an important question arises regarding the kind of formal political institution that would speak in the name of all these initiatives. In France, some intellectuals who have an interest in these solidarity initiatives see them as new economic models with the potential to solve the current financial crisis, and they are eager for academic specialists and leaders of the movement to achieve some kind of consensus about the kind of concrete political identity such initiatives may be expected to generate. However this paper studies their way of establishing a basis for moving from micro level initiatives to substantial “macro” polity unity. Using the insights of french pragmatic sociology, and particularly the notion of grammar of justification, it aims to understand what the obstacles to this aim being realised are. [less ▲]

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See detailPotential contribution of progesterone receptors to the development of sexual behavior in male and female mice.
Desroziers, Elodie; Brock, Olivier; Bakker, Julie ULg

in Hormones and Behavior (2016)

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in ... [more ▼]

We previously showed that estradiol can have both defeminizing and feminizing effects on the developing mouse brain. Pre- and early postnatal estradiol defeminized the ability to show lordosis in adulthood, whereas prepubertal estradiol feminized this ability. Furthermore, we found that estradiol upregulates progesterone receptors (PR) during development, inducing both a male-and female-typical pattern of PR expression in the mouse hypothalamus. In the present study, we took advantage of a newly developed PR antagonist (ZK 137316) to determine whether PR contributes to either male- or female-typical sexual differentiation. Thus groups of male and female C57Bl/6j mice were treated with ZK 137316 or oil as control: males were treated neonatally (P0-P10), during the critical period for male sexual differentiation, and females were treated prepubertally (P15-P25), during the critical period for female sexual differentiation. In adulthood, mice were tested for sexual behavior. In males, some minor effects of neonatal ZK treatment on sexual behavior were observed: latencies to the first mount, intromission and ejaculation were decreased in neonatally ZK treated males; however, this effect disappeared by the second mating test. By contrast, female mice treated with ZK during the prepubertal period showed significantly less lordosis than OIL-treated females. Mate preferences were not affected in either males or females treated with ZK during development. Taken together, these results suggest a role for PR and thus perhaps progesterone in the development of lordosis behavior in female mice. By contrast, no obvious role for PR can be discerned in the development of male sexual behavior. [less ▲]

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See detailCrop model improvement reduces the uncertainty of the response to temperature of multi-model ensembles
Maiorano, Andrea; Martre, Pierre; Asseng, Senthold et al

in Field Crops Research (2016), In press

o improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the ... [more ▼]

o improve climate change impact estimates and to quantify their uncertainty, multi-model ensembles (MMEs) have been suggested. Model improvements can improve the accuracy of simulations and reduce the uncertainty of climate change impact assessments. Furthermore, they can reduce the number of models needed in a MME. Herein, 15 wheat growth models of a larger MME were improved through re-parameterization and/or incorporating or modifying heat stress effects on phenology, leaf growth and senescence, biomass growth, and grain number and size using detailed field experimental data from the USDA Hot Serial Cereal experiment (calibration data set). Simulation results from before and after model improvement were then evaluated with independent field experiments from a CIMMYT world-wide field trial network (evaluation data set). Model improvements decreased the variation (10th to 90th model ensemble percentile range) of grain yields simulated by the MME on average by 39% in the calibration data set and by 26% in the independent evaluation data set for crops grown in mean seasonal temperatures >24 °C. MME mean squared error in simulating grain yield decreased by 37%. A reduction in MME uncertainty range by 27% increased MME prediction skills by 47%. Results suggest that the mean level of variation observed in field experiments and used as a benchmark can be reached with half the number of models in the MME. Improving crop models is therefore important to increase the certainty of model-based impact assessments and allow more practical, i.e. smaller MMEs to be used effectively. [less ▲]

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See detailPalindromic sequences generated from marked morphisms
Labbé, Sébastien ULg; Pelantova, Edita

in European Journal of Combinatorics (2016), 51

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See detailExistence of two groups of Staphylococcus aureus strains isolated from bovine mastitis based on biofilm formation, intracellular survival, capsular profile and agr-typing.
Bardiau, Marjorie ULg; Caplin, Jonathan; Detilleux, Johann ULg et al

in Veterinary microbiology (2016), 185

Staphylococcus (S.) aureus is recognised worldwide as an important pathogen causing contagious acute and chronic bovine mastitis. Chronic mastitis account for a significant part of all bovine cases and ... [more ▼]

Staphylococcus (S.) aureus is recognised worldwide as an important pathogen causing contagious acute and chronic bovine mastitis. Chronic mastitis account for a significant part of all bovine cases and represent an important economic problem for dairy producers. Several properties (biofilm formation, intracellular survival, capsular expression and group agr) are thought to be associated with this chronic status. In a previous study, we found the existence of two groups of strains based on the association of these features. The aim of the present work was to confirm on a large international and non-related collection of strains the existence of these clusters and to associate them with case history records. In addition, the genomes of eight strains were sequenced to study the genomic differences between strains of each cluster. The results confirmed the existence of both groups based on capsular typing, intracellular survival and agr-typing: strains cap8-positive, belonging to agr group II, showing a low invasion rate and strains cap5-positive, belonging to agr group I, showing a high invasion rate. None of the two clusters were associated with the chronic status of the cow. When comparing the genomes of strains belonging to both clusters, the genes specific to the group "cap5-agrI" would suggest that these strains are better adapted to live in hostile environment. The existence of these two groups is highly important as they may represent two clusters that are adapted differently to the host and/or the surrounding environment. [less ▲]

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See detailL'atlas à l'épreuve de l'image en mouvement (Warburg, Farocki, Didi-Huberman)
Hagelstein, Maud ULg; Hamers, Jérémy ULg

in MethIS : Méthodes et Interdisciplinarité en Sciences Humaines (2016)

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes ... [more ▼]

Partant des travaux récents de Georges Didi-Huberman sur l’atlas d’images (A. Warburg) comme outil et support d’une nouvelle heuristique du montage, ce texte confronte l’installation Histoires de fantômes pour grandes personnes (G. Didi-Huberman, A. Gisinger, 2012), composée pour partie d’images en mouvement, à la pensée de la table warburgienne comme lieu d’une perpétuelle reconfiguration et d’une nouvelle lisibilité du monde. Se pourrait-il en effet qu’une image en mouvement, prise d’ordinaire dans un continuum clos, se dote, à travers le montage, des mêmes potentialités critiques – c’est-à-dire d’un même pouvoir inquiétant – que l’image fixe offerte au déambulateur de l’atlas ? [less ▲]

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See detailPhotocatalytic decomposition of hydrogen peroxide over nanoparticles of TiO2 and Ni(II)-porphyrin doped TiO2: a relationship between activity and porphyrin anchoring mode
Tasseroul, Ludivine ULg; Pàez Martinez, Carlos ULg; Lambert, Stéphanie ULg et al

in Applied Catalysis B : Environmental (2016), 182

The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared ... [more ▼]

The nickel tetra(4-carboxyphenyl)porphyrin (TCPPNi) was chimisorbed on Degussa P25 TiO2 at different concentrations. Diffuse reflectance spectroscopy in the UV/vis region, Fourier transform infrared spectroscopy and thermal gravimetry combined with differential scanning calorimetry measurements allowed the determination of the TCPPNi anchoring mode. At low TCPPNi concentrations, this anchoring on Degussa P25 TiO2 took place through all four carboxylic groups, while at higher concentrations the anchoring occurred through one or two carboxylic groups. For the firsttime,the effect of UV/vis light irradiation on the H2O2-degradation activity of TiO2 and TCPPNi-doped TiO2 was studied using the method of following the production of O2 by gas pressure monitoring. The activity of seven different catalysts was related to the TCPPNi anchoring mode and the percentage of TiO2 Degussa P25 coverage. An optimum degradation of H2O2 was observed for 0.0115 mol TCPPNi × g−1 P25. In that case, the TCPPNi was anchored through the four carboxylic groups, corresponding to a strong interaction with Degussa P25 TiO2. Moreover, the TCPPNi did not cover the surface completely, therefore allowing the light to reach and activate the TiO2. [less ▲]

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See detailMetal binding to the N-terminal cytoplasmic domain of the PIB ATPase HMA4 is required for metal transport in Arabidopsis.
Laurent, Clémentine ULg; Lekeux, Gilles ULg; Ukuwela, Ashwinie A et al

in Plant Molecular Biology (2016), 90

PIB ATPases are metal cation pumps that transport metals across membranes. These proteins possess N- and C-terminal cytoplasmic extensions that contain Cys- and His-rich high affinity metal binding ... [more ▼]

PIB ATPases are metal cation pumps that transport metals across membranes. These proteins possess N- and C-terminal cytoplasmic extensions that contain Cys- and His-rich high affinity metal binding domains, which may be involved in metal sensing, metal ion selectivity and/or in regulation of the pump activity. The PIB ATPase HMA4 (Heavy Metal ATPase 4) plays a central role in metal homeostasis in Arabidopsis thaliana and has a key function in zinc and cadmium hypertolerance and hyperaccumulation in the extremophile plant species Arabidopsis halleri. <br />Here, we examined the function and structure of the N-terminal cytoplasmic metal-binding domain of HMA4. We mutagenized a conserved CCTSE metal-binding motif in the domain and assessed the impact of the mutations on protein function and localization in planta, on metal-binding properties in vitro and on protein structure by Nuclear Magnetic Resonance spectroscopy. <br />The two Cys residues of the motif are essential for the function, but not for localization, of HMA4 in planta, whereas the Glu residue is important but not essential. These residues also determine zinc coordination and affinity. Zinc binding to the N-terminal domain is thus crucial for HMA4 protein function, whereas it is not required to maintain the protein structure. <br />Altogether, combining in vivo and in vitro approaches in our study provides insights towards the molecular understanding of metal transport and specificity of metal P-type ATPases. [less ▲]

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See detailFe3+/Iron Oxide/SiO2 Xerogel Catalysts for p-nitrophenol Degradation by Photo-Fenton Effects: Influence of Thermal Treatment on Catalysts Texture
Mahy, Julien ULg; Tasseroul, Ludivine ULg; Herlitscke, Marcus et al

in Materials Today: Proceedings (2016), 3(2), 464-469

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. Four thermal treatments were applied to catalysts: drying, drying-autoclaving, calcination and calcination-autoclaving. Textural characterizations show that the specific surface area is increased by calcination while materials microporosity completely collapse when using autoclaving. Based on Mössbauer spectroscopy and magnetometry measurements, only Fe3+ species were observed in xerogel catalysts. The photo-Fenton effect of these catalysts was evaluated on the degradation of p-nitrophenol in aqueous media. In the presence of H2O2, results show that this effect reachs 99% of degradation after 24 h. Mössbauer and catalytic tests are presented in another paper. [less ▲]

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