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See detailLakeMIP Kivu: evaluating the representation of a large, deep tropical lake by a set of one-dimensional lake models
Thiery, Wim; Stepanenko, Victor M.; Fang, Xing et al

in Tellus : Series A (2014), 66

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See detailEXPLORATION ET TRAITEMENT D’UN CARCINOME EPIDERMOIDE GANGLIONNAIRE CERVICAL SANS PRIMITIF DECELE
WERENNE, Xavier ULg; SAUTOIS, Brieuc ULg; DEMEZ, Pierre ULg et al

in Revue Médicale de Liège (2014), 69(Supp 1), 58-62

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément ... [more ▼]

A l’heure actuelle, le bilan à réaliser après décou - verte d’une adénopathie cervicale est bien codifié. Le PET- scan, dans un premier temps controversé, s’affirme étude après étude comme un élément essentiel. La stratégie de traitement pratiquée dans la plupart des centres consiste en un évidemment cervical suivi de radiothérapie portant sur les muqueuses pharyngées ainsi que sur les relais ganglion - naires cervicaux bilatéraux avec éventuelle association à une chimiothérapie. Celle-ci est ajoutée en fonction de facteurs anatomo-pathologiques de mauvais pronostic, mais elle n’a pas fait la preuve de sa supériorité. De multiples études de phase II aboutissent d’ailleurs à des conclusions opposées. En dehors de données issues d’études randomisées, le traitement aujourd’hui se décide par analogie à ceux qui sont appliqués lorsque le site primitif tumoral est identifié dans la sphère ORL. [less ▲]

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See detailEstimation of the error density in a semiparametric transformation model
Colling, Benjamin; Heuchenne, Cédric ULg; Samb, Rawane et al

in Annals of the Institute of Statistical Mathematics (2014)

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See detailLa gouvernance environnementale au Sud : regard sur un projet de conservation des tortues au Sri Lanka
Rosillon, Caroline ULg

in ethnographiques.org (2014), 27

Les régions rurales du Sud du Sri Lanka sont soumises aujourd'hui à des tensions croissantes entre un développement économique précipité et la conservation des ressources naturelles qui participent à la ... [more ▼]

Les régions rurales du Sud du Sri Lanka sont soumises aujourd'hui à des tensions croissantes entre un développement économique précipité et la conservation des ressources naturelles qui participent à la renommée de l'île. Dans ce contexte, l'article se penche sur la question des initiatives locales de protection de la biodiversité à travers une étude de cas portant sur un projet de conservation des tortues de mer dans le district d'Hambantota (l'ONG-T). Dans une perspective d'anthropologie politique, l'analyse met en lumière la manière dont ce type de projet s'intègre et influence les structures sociopolitiques dans la société locale. Après avoir brièvement présenté quelques données contextuelles et historiques sur le village de pêcheurs dans laquelle est implantée l'ONG, l'étude de cas révèle les nouvelles formes d'interactions, les enjeux de pouvoirs et les conflits que peut susciter localement l'implantation de ce type de projet. [less ▲]

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See detailValidation d’un test d’inhibition auprès d’enfants présentant un trouble déficitaire de l’attention avec/sans hyperactivité
Catale, Corinne ULg; Lejeune, Caroline ULg; Schmitz, Xavier ULg et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2014), 46(1), 66-72

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the ... [more ▼]

The objective of this study was to assess the development of inhibition in 5-11 years old children with the “Stroop fruit” task (see Archibald & Kerns, 1999; Catale & Meulemans, 2005) and to examine the clinical value of this tool. 346 French-speaking children without any developmental disorders or learning disabilities were included in this study. A clinical group of 25 children with attention deficit and hyperactivity disorder was also assessed with this task. Developmental analyses on age groups show an enhancement of performance in the interference condition between 5 and 8 years old. Furthermore, results also show that the clinical group performed significantly less accurately that the control group for the interference condition, which confirms the clinical interest of this tool. [less ▲]

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See detailChemical composition, cytotoxicity and in vitro antitrypanosomal and antiplasmodial activity of the essential oils of four Cymbopogon species from Benin.
Kpoviessi, Salome; Bero, Joanne; Agbani, Pierre et al

in Journal of ethnopharmacology (2014), 151

ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon species are largely used in folk medicine for the treatment of many diseases some of which related to parasitical diseases as fevers and headaches. As part of ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Cymbopogon species are largely used in folk medicine for the treatment of many diseases some of which related to parasitical diseases as fevers and headaches. As part of our research on antiparasitic essential oils from Beninese plants, we decided to evaluate the in vitro antiplasmodial and antitrypanosomal activities of essential oils of four Cymbopogon species used in traditional medicine as well as their cytotoxicity. MATERIALS AND METHODS: The essential oils of four Cymbopogon species Cymbopogon citratus (I), Cymbopogon giganteus (II), Cymbopogon nardus (III) and Cymbopogon schoenantus (IV) from Benin obtained by hydrodistillation were analysed by GC/MS and GC/FID and were tested in vitro against Trypanosoma brucei brucei and Plasmodium falciparum respectively for antitrypanosomal and antiplasmodial activities. Cytotoxicity was evaluated in vitro against Chinese Hamster Ovary (CHO) cells and the human non cancer fibroblast cell line (WI38) through MTT assay to evaluate the selectivity. RESULTS: All tested oils showed a strong antitrypanosomal activity with a good selectivity. Sample II was the most active against Trypanosoma brucei brucei and could be considered as a good candidate. It was less active against Plasmodium falciparum. Samples II, III and IV had low or no cytotoxicity, but the essential oil of Cymbopogon citraus (I), was toxic against CHO cells and moderately toxic against WI38 cells and needs further toxicological studies. Sample I (29 compounds) was characterised by the presence as main constituents of geranial, neral, beta-pinene and cis-geraniol; sample II (53 compounds) by the presence of trans-p-mentha-1(7),8-dien-2-ol, trans-carveol, trans-p-mentha-2,8-dienol, cis-p-mentha-2,8-dienol, cis-p-mentha-1(7),8-dien-2-ol, limonene, cis-carveol and cis-carvone; sample III (28 compounds) by beta-citronellal, nerol, beta-citronellol, elemol and limonene and sample IV (41 compounds) by piperitone, (+)-2-carene, limonene, elemol and beta-eudesmol. CONCLUSIONS: Our study shows that essential oils of Cymbopogon genus can be a good source of antitrypanosomal agents. This is the first report on the activity of these essential oils against Trypanosoma brucei brucei, Plasmodium falciparum and analysis of their cytotoxicity. [less ▲]

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See detailLong-term fracture rates seen with continued ibandronate treatment : pooled analysis of DIVA and MOBILE long-term extension studies
Miller, PD; Recker, RR; Harris, S et al

in Osteoporosis International (2014), 25(1), 349-357

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See detailAssociative learning of Nasonia vitripennis Walker (Hymenoptera: Pteromalidae) to methyldisulfanylmethane
Frederickx, Christine ULg; Verheggen, François ULg; Brostaux, Yves ULg et al

in Journal of Forensic Sciences (2014)

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The ... [more ▼]

Traditional methods of volatile detection used by police typically consist of reliance on canine olfaction. However, dogs have some limitations such as cost of training and time of conditioning. The possibility of using parasitic wasps for detecting explosives and narcotics has been developed. Moreover, wasps are cheap to produce and can be conditioned with impressive speed for a specific chemical-detection task. We examined the ability of Nasonia vitripennis Walker to learn and respond to methydisulfanylmethane (DMDS), a volatile discriminator of cadaver. The training aimed to form an association between an unconditioned stimulus (pupae) and the conditioned stimulus (odor source). After the training, the time spent of conditioned wasps in the DMDS chamber was measured. Statistical analysis showed that the increasing concentrations involved an increase in the time spent in the chamber containing DMDS. This study indicates that N. vitripennis can respond to DMDS, which provide further support for its development as a biological sensor. [less ▲]

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See detailCognitive and neuroimaging evidence of impaired interaction between Self and memory in Alzheimer’s disease.
Genon, Sarah ULg; Genon, Sarah ULg; Bahri, Mohamed Ali ULg et al

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2014), 51

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect ... [more ▼]

In human cognition, self and memory processes strongly interact, as evidenced by the memory advantage for self-referential materials (Self Reference Effect (SRE) and Self Reference Recollection Effect (SRRE)). The current study examined this interaction at the behavioural level and its neural correlates in patients with Alzheimer’s disease (AD). Healthy older controls (HC) and AD patients performed trait-adjectives judgements either for self-relevance or for other-relevance (encoding phase). In a first experiment, the encoding and subsequent yes-no recognition phases were administrated in an MRI scanner. Brain activation as measured by fMRI was examined during self-relevance judgements and anatomical images were used to search for correlation between the memory advantage for self-related items and grey matter density (GMD). In a second experiment, participants described the retrieval experience that had driven their recognition decisions (familiarity vs. recollective experience). The behavioural results revealed that the SRE and SRRE were impaired in AD patients compared to HC participants. Furthermore, verbal reports revealed that the retrieval of self-related information was preferentially associated with the retrieval of contextual details, such as source memory in the HC participants, but less so in the AD patients. Our imaging findings revealed that both groups activated the medial prefrontal cortex (MPFC) at encoding during self-relevance judgments. However, the variable and limited memory advantage for self-related information was associated with GMD in the lateral prefrontal cortex in the AD patients, a region supporting high-order processes linking self and memory. These findings suggest that even if AD patients engage MPFC during self-referential judgments, the retrieval of self-related memories is qualitatively and quantitatively impaired in relation with altered high-order processes in the lateral PFC. [less ▲]

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See detailSnijders’ correction of Infit and Outfit indexes with estimated ability level : an analysis with the Rasch model
Magis, David ULg; Béland, Sébastien; Raîche, Gilles

in Journal of Applied Measurement (2014), 15

The Infit mean square W and the Outfit mean square U are commonly used person fit indexes under Rasch measurement. However, they suffer from two major weaknesses. First, their asymptotic distribution is ... [more ▼]

The Infit mean square W and the Outfit mean square U are commonly used person fit indexes under Rasch measurement. However, they suffer from two major weaknesses. First, their asymptotic distribution is usually derived by assuming that the true ability levels are known. Second, such distributions are even not clearly stated for indexes U and W. Both issues can seriously affect the selection of an appropriate cut-score for person fit identification. Snijders (2001) proposed a general approach to correct some person fit indexes when specific ability estimators are used. The purpose of this paper is to adapt this approach to U and W indexes. First, a brief sketch of the methodology and its application to U and W is proposed. Then, the corrected indexes are compared to their classical versions through a simulation study. The suggested correction yields controlled Type I errors against both conservatism and inflation, while the power to detect specific misfitting response patterns gets significantly increased. [less ▲]

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See detailCardiovascular safety of strontium ranelate: real-life assessment in clinical practice.
Donneau, Anne-Françoise ULg; Reginster, Jean-Yves ULg

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

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See detailOsteonecrosis of the jaw in a male osteoporotic patient treated with denosumab
NEUPREZ, Audrey ULg; Coste, S; Rompen, Eric ULg et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2014), 25

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the ... [more ▼]

Osteonecrosis of the jaw (ONJ) is a clinical condition associated with long-term exposure to inhibitors of bone resorption, mainly bisphosphonates. Denosumab (DMab) is a human monoclonal antibody of the receptor activator of nuclear factor kappa-B ligand. It prevents osteoclast-mediated bone resorption and is widely prescribed for the management of postmenopausal osteoporosis. Whereas ONJ has already been reported in women treated with DMab, we report for the first time the development of ONJ, following tooth extraction, in a male patient treated for idiopathic osteoporosis with DMab. Due to the constant increase in DMab prescription, for the management of osteoporosis, in both genders, physicians should be made aware of this potential risk. [less ▲]

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See detailImpact of purification and fractionation process on the chemical structure and physical properties of locust bean gum
Gillet, Sébastien ULg; Blecker, Christophe ULg; Aguedo, Mario ULg et al

in Carbohydrate Polymers (2014)

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on ... [more ▼]

Crude locust bean gum (CLBG) was purified and fractionated into two parts : the first was obtained by solubilization in water at 25 °C (GM25) and the second consisted in a further extraction at 80 °C on the residual impoverished fraction (GM80). The complete structural characterization has shown that GM80 possessed relatively longer chain lengths than GM25, a slightly lower degree of galactose substitution and a somewhat sharper galactosyl distribution in substituted and unsubstituted regions. A physical behavior analysis was carried out on solubilization kinetics, viscosity, viscoelasticity and formation of associated gels with xanthan or carrageenan. The average structure of GM80 generated larger intra-chain, inter-chain and inter-molecular interactions, resulting in the appearance of a stronger network. Small structural differences therefore generated very different physical behaviors. This study thus allowed to establish, in a precise and complete manner, fractionation-purification-structure-function relationships of galactomannans extracted from carob. [less ▲]

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See detailCompte rendu de Han BALTUSSEN, Michael ATKINSON, Michael SHARE, Ian MUELLER (trad.), Simplicius: On Aristotle Physics 1.5-9
Gavray, Marc-Antoine ULg

in International Journal of the Platonic Tradition (2014), 8(1), 115-117

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See detailInterstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance
Pretty, Christopher G.; Le Compte, Aaron; Penning, Sophie ULg et al

in Computer Methods and Programs in Biomedicine (2014)

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See detailquelques messages choisis de l'ECCO 17
COUCKE, Philippe ULg

in Onco : Revue Multidisciplinaire d'Oncologie (2014), 8(1), 8-11

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See detailEtudes des propriétés psychométriques de la CES-D sur un échantillon d'adolescents francophones scolarisés
Boulard, Aurore ULg; Gauthier, Jean-Marie ULg; Born, Michel ULg

in L'Encéphale (2014)

L’objectif de cet article est d’étudier et valider la version francaise de l’échelle de dépression Center for Epidemiologic Studies Depression Scale (CES-D) mise au point par Radloff (en 1977) dans une ... [more ▼]

L’objectif de cet article est d’étudier et valider la version francaise de l’échelle de dépression Center for Epidemiologic Studies Depression Scale (CES-D) mise au point par Radloff (en 1977) dans une population d’adolescents scolarisés. [less ▲]

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See detailDisease management patterns for postmenopausal women in Europe with hormone-receptor-positive, human epidermal growth factor receptor-2 negative advanced breast cancer.
Andre, Fabrice; Neven, Patrick; Marinsek, Nina et al

in Current medical research and opinion (2014)

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of ... [more ▼]

Abstract Background: International guidelines for hormone-receptor-positive (HR+), human epidermal growth factor receptor-2 negative (HER2-) advanced breast cancer (BC) recommend sequential lines of hormonal therapy (HT), and only recommend chemotherapy for patients with extensive visceral involvement or rapidly progressive disease. This study evaluated actual physician-reported treatments for advanced BC in Europe. Methods: We conducted a retrospective chart review of 355 postmenopausal women with HR+, HER2- advanced BC who progressed on >/=1 line of HT (adjuvant or advanced) and completed >/=1 line of chemotherapy (advanced). Treatment choice was evaluated for each line of therapy. Results: Of 355 patients, 111 (31%) received first-line chemotherapy, whereas 218 (61%) and 26 (7%) switched from HT to chemotherapy in second and third line, respectively. More patients receiving first-line HT had bone metastases (73% vs 27% chemotherapy). Patients treated with first-line chemotherapy had more brain (12% vs 3% HT) or extensive liver (13% vs 6% HT) metastases. Subgroup analysis of 188 patients who received first-line HT and had de novo advanced BC or relapsed/recurrent disease more than 1 year after adjuvant therapy found that the majority (89%; n = 167) of these patients switched to chemotherapy in second line. However, among these 167 patients, 27% had no significant changes in metastases between first and second line. Among the 73% of patients who had significant changes in metastases, 20% had no brain metastases or extensive visceral disease. Conclusions: Our study suggests that the guideline-recommended use of multiple HT lines is open to interpretation and that optimal treatment for European postmenopausal women with HR+, HER2- advanced BC who responded to HT may not be achieved. [less ▲]

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See detailPrimary production in a tropical large lake: The role of phytoplankton composition
Darchambeau, François ULg; Sarmento, Hugo; Descy, Jean-Pierre

in Science of the Total Environment (2014), 473-474

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See detailConcomitant manipulation of NMDA- and AMPA-receptors to produce pro-cognitive drug effects
Vignisse, Julie ULg; Steinbusch, Harry W.M.; Grigoriev, Vladimir et al

in European Neuropsychopharmacology (2014), 24

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA ... [more ▼]

Bifunctional drug therapy targeting distinct receptor signaling systems can generate increased efficacy at lower concentrations compared to monofunctional therapy. Non-competitive blockade of the NMDA receptors or the potentiation of AMPA receptors is well documented to result in memory enhancement. Here, we compared the efficacy of the low-affinity NMDA receptor blocker memantine or the positive modulator of AMPA receptor QXX (in C57BL/6J at 1 or 5 mg/kg, ip) with new derivatives of isothiourea (0.5-1 mg/kg, ip) that have bifunctional efficacy. Low-affinity NMDA blockade by these derivatives was achieved by introducing greater flexibility into the molecule, and AMPA receptor stimulation was produced by a sulfamide-containing derivative of isothiourea. Contextual learning was examined in a step-down avoidance task and extinction of contextual memory was studied in a fear-conditioning paradigm. Memantine enhanced contextual learning while QXX facilitated memory extinction; both drugs were effective at 5 mg/kg. The new derivative IPAC-5 elevated memory scores in both tasks at the dose 0.5 mg/Kg and exhibited the lowest IC50 values of NMDA receptor blockade and highest potency of AMPA receptor stimulation. Thus, among the new drugs tested, IPAC-5 plicated the properties of memantine and QXX in one administration with increased potency. Our data suggest that a concomitant manipulation of NMDA- and AMPA-receptors results in pro-cognitive effects and supports the concept bifunctional drug therapy as a promising strategy to replace monofunctional therapies with greater efficacy and improved compliance. [less ▲]

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See detailLack of isocitrate lyase in Chlamydomonas leads to changes in carbon metabolism and in the response to oxidative stress under mixotrophic growth.
Plancke, Charlotte; Vigeolas, Hélène ULg; Hohner, Ricarda et al

in The Plant journal : for cell and molecular biology (2014), 77(3), 404-417

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the ... [more ▼]

Isocitrate lyase is a key enzyme of the glyoxylate cycle. This cycle plays an essential role in cell growth on acetate, and is important for gluconeogenesis as it bypasses the two oxidative steps of the tricarboxylic acid (TCA) cycle in which CO2 is evolved. In this paper, a null icl mutant of the green microalga Chlamydomonas reinhardtii is described. Our data show that isocitrate lyase is required for growth in darkness on acetate (heterotrophic conditions), as well as for efficient growth in the light when acetate is supplied (mixotrophic conditions). Under these latter conditions, reduced acetate assimilation and concomitant reduced respiration occur, and biomass composition analysis reveals an increase in total fatty acid content, including neutral lipids and free fatty acids. Quantitative proteomic analysis by 14 N/15 N labelling was performed, and more than 1600 proteins were identified. These analyses reveal a strong decrease in the amounts of enzymes of the glyoxylate cycle and gluconeogenesis in parallel with a shift of the TCA cycle towards amino acid synthesis, accompanied by an increase in free amino acids. The decrease of the glyoxylate cycle and gluconeogenesis, as well as the decrease in enzymes involved in beta-oxidation of fatty acids in the icl mutant are probably major factors that contribute to remodelling of lipids in the icl mutant. These modifications are probably responsible for the elevation of the response to oxidative stress, with significantly augmented levels and activities of superoxide dismutase and ascorbate peroxidase, and increased resistance to paraquat. [less ▲]

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See detailDrug-Drug Interactions with Sodium-Glucose Cotransporters Type 2 (SGLT2) Inhibitors, New Oral Glucose-Lowering Agents for the Management of Type 2 Diabetes Mellitus.
Scheen, André ULg

in Clinical pharmacokinetics (2014)

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel ... [more ▼]

Inhibitors of sodium-glucose cotransporters type 2 (SGLT2) reduce hyperglycaemia by decreasing renal glucose threshold and thereby increasing urinary glucose excretion. They are proposed as a novel approach for the management of type 2 diabetes mellitus. They have proven their efficacy in reducing glycated haemoglobin, without inducing hypoglycaemia, as monotherapy or in combination with various other glucose-lowering agents, with the add-on value of promoting some weight loss and lowering arterial blood pressure. As they may be used concomitantly with many other drugs, we review the potential drug-drug interactions (DDIs) regarding the three leaders in the class (dapagliglozin, canagliflozin and empagliflozin). Most of the available studies were performed in healthy volunteers and have assessed the pharmacokinetic interferences with a single administration of the SGLT2 inhibitor. The exposure [assessed by peak plasma concentrations (C max) and area under the concentration-time curve (AUC)] to each SGLT2 inhibitor tested was not significantly influenced by the concomitant administration of other glucose-lowering agents or cardiovascular agents commonly used in patients with type 2 diabetes. Reciprocally, these medications did not influence the pharmacokinetic parameters of dapagliflozin, canagliflozin or empagliflozin. Some modest changes were not considered as clinically relevant. However, drugs that could specifically interfere with the metabolic pathways of SGLT2 inhibitors [rifampicin, inhibitors or inducers of uridine diphosphate-glucuronosyltransferase (UGT)] may result in significant changes in the exposure of SGLT2 inhibitors, as shown for dapagliflozin and canagliflozin. Potential DDIs in patients with type 2 diabetes receiving chronic treatment with an SGLT2 inhibitor deserve further attention, especially in individuals treated with several medications or in more fragile patients with hepatic and/or renal impairment. [less ▲]

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See detailBrominated and phosphorus flame retardants in White-tailed Eagle Haliaeetus albicilla nestlings: Bioaccumulation and associations with dietary proxies (δ13C, δ15N and δ34S)
Eulaers, Igor; Jaspers, Veerle; Halley, Duncan et al

in Science of the Total Environment (2014), 478

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation ... [more ▼]

Very little is known on the exposure of high trophic level species to current-use brominated (BFRs) and phosphorus flame retardants (PFRs), although observations on their persistence, bioaccumulation potential, and toxicity have been made. We investigated the accumulation of BFRs and PFRs, and their associations with dietary proxies (δ13C, δ15N and δ34S), in plasma and feathers of White-tailed Eagle Haliaeetus albicilla nestlings from Trøndelag, Norway. In addition to accumulation of a wide range of polybrominated diphenyl ether (PBDE) congeners in both plasma and feathers, all non-PBDE BFRs and PFRs could be measured in feathers, while in plasma only two of six PFRs, i.e. tris-(2-chloroisopropyl) phosphate (TCIPP) and tris-(2,3-dichloropropyl) phosphate (TDCPP) were detected. PFR concentrations in feathers (0.95-3,000 ng g-1) were much higher than selected organochlorines (OCs), such as polychlorinated biphenyl 153 (CB 153; 2.3-15 ng g-1) and dichlorodiphenyldichloroethylene (p,p’-DDE; 2.3-21 ng g-1), PBDEs (0.03-2.3 ng g-1) and non-PBDE BFRs (0.03-1.5 ng g-1). Non-significant associations of PFR concentrations in feathers with those in plasma (P≥0.74), and their similarity to reported atmospheric PFR concentrations, may suggest atmospheric PFR deposition on feathers. Most OCs and PBDEs, as well as tris(chloroethyl) phosphate (TCEP), tris(phenyl) phosphate (TPHP) and tri-(2-butoxyethyl) phosphate (TBOEP) were associated to δ15N and/or δ13C (all P≤0.02). Besides δ15N enrichment, δ34S was depleted in nestlings from fjords, inherently close to an urbanised centre. As such, both may have been a spatial proxy for anthropogenic disturbance, possible confounding their use as dietary proxy. [less ▲]

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See detailAnalysis of collagen preservation in bones recovered in archaeological contexts using NIR Hyperspectral Imaging
Vincke, Damien; Miller, Rebecca ULg; Stassart, Edith ULg et al

in Talanta (2014), 125

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen ... [more ▼]

The scope of this article is to propose an innovative method based on Near Infrared Hyperspectral Chemical Imaging (NIR-HCI) to rapidly and non-destructively evaluate the relative degree of collagen preservation in bones recovered from archaeological contexts. This preliminary study has allowed the evaluation of the potential of the method using bone samples from the Early Upper Palaeolithic, Mesolithic and Neolithic periods at the site of Trou Al'Wesse in Belgium. NIR-HCI, combined with chemometric tools, has identified specific spectral bands characteristic of collagen. A chemometric model has been built using Partial Least Squares Discriminant Analysis (PLS-DA) to identify bones with and without collagen. This enables the evaluation of the degree of collagen preservation and homogeneity in bones within and between different strata, which has direct implications for archaeological applications (e.g., taphonomic analyses, assemblage integrity) and sample selection for sub- sequent analyses requiring collagen. Two archaeological applications are presented: comparison between sub-layers in an Early Upper Palaeolithic unit, and evaluation of the range of variability in collagen preservation within a single Holocene stratum. [less ▲]

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See detailLa Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique ULg

in Revue Médicale de Liège (2014)

Diagnostic criteria and pathophysiology of narcolepsy- cataplexy have evolved considerably over the last 10 years. The main cause, already mentioned in a previous paper, in the Revue Médicale de Liège, in ... [more ▼]

Diagnostic criteria and pathophysiology of narcolepsy- cataplexy have evolved considerably over the last 10 years. The main cause, already mentioned in a previous paper, in the Revue Médicale de Liège, in 2002, is based, in human beings, on a destruction of specific cells located in the lateral and posterior part of the hypothalamus (the perifornical nuclei, containing some 70,000 neurons), producing peptides which stimulate the central nervous system; they are called hypocretins or orexins. The role of autoimmunity in their disappearance becomes more evident. The treatment is simplified but remains symptomatic. It is mainly based on Sodium Oxybate or Gamma-Hydroxybutyrate, syrup, prescribed for the night. The authors report on their own experience in this regard and on future therapeutics more targeted towards the cause of the disease. [less ▲]

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See detailLa culture comme objet
Badir, Sémir ULg

in Semiotica (2014), 198

La culture peut-elle être un objet d’étude à part entière ? Les sciences de la culture le donnent implicitement à penser par leur intitulé même, à l’instar de ce qu’ont poursuivi, à l’égard de leurs ... [more ▼]

La culture peut-elle être un objet d’étude à part entière ? Les sciences de la culture le donnent implicitement à penser par leur intitulé même, à l’instar de ce qu’ont poursuivi, à l’égard de leurs objets respectifs, les sciences de l’homme, de la société et de la vie. Une telle objectivation, toutefois, ne va pas de soi, les caractères définitoires de la culture — à la fois comme totalité et comme singularité — dérogent à l’objectivation scientifique ordinaire. Dans un premier temps, on commence par considérer trois tentatives d’objectivation de la culture menées en sémiotique, sous le rapport de la sémiosphère (Lotman), de l’esthésie (Rastier) et de la langue. Le crédit accordé à la troisième tentative nous invite à interroger, dans un second temps, le rapport entre langue, texte et culture à partir de la distinction théorique proposée par Hjelmslev entre analyse et fragmentation. Langue, texte et culture sont fonction d’un seul objet empirique pour lesquelles différentes focalisations sont possibles. C’est une fonction restreinte et analytique qui règle le rapport des textes à la langue ; au contraire c’est une fonction extensive, fragmentée et synthétique qui laisse voir les textes comme des œuvres insérées dans les pratiques de la culture. [less ▲]

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See detailGeometric ferroelectricity in fluoroperovskites
Garcia-Castro, A. C.; Spaldin, Nicola A.; Romero, A. H. et al

in Physical Review B (2014), 89

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are ... [more ▼]

We used first-principles calculations to investigate the existence and origin of the ferroelectric instability in the ABF3 fluoroperovskites. While the ground states of most ABF3 compounds are paraelectric (Pnma phase), we find that many fluoroperovskites have a ferroelectric instability in their high-symmetry cubic structure that is of similar amplitude to that commonly found in oxide perovskites. In contrast to the oxides, however, the fluorides have nominal Born effective charges, indicating a different mechanism for the instability.We show that the instability originates from ionic size effects, and is therefore in most cases largely insensitive to pressure and strain, again in contrast to the oxide perovskites. An exception is NaMnF3, where coherent epitaxial strain matching to a substrate with equal in-plane lattice constants destabilizes the bulk Pnma structure, leading to a ferroelectric, and indeed multiferroic, ground state with an unusual polarization/strain response. [less ▲]

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See detailThe relevance of the cooperative model in the field of renewable energy
Huybrechts, Benjamin ULg; Mertens de Wilmars, Sybille ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (2014), 85(2),

This article examines the relevance of the cooperative model in the field of renewable energy (RE). RE sources have been developed since the end of the 1970s and their growth has been expansive since then ... [more ▼]

This article examines the relevance of the cooperative model in the field of renewable energy (RE). RE sources have been developed since the end of the 1970s and their growth has been expansive since then. While social-ecological movements have been instrumental in shifting the public attention towards the need for alternative energies (Sine and Lee, 2009), in most countries the sector has rapidly become dominated by corporate actors experienced in building large-scale RE projects. In an attempt to counter the corporate hegemony and to protect available lands, a range of citizen initiatives have emerged under different forms and names such as community energy groups or renewable energy (source) cooperatives (van der Horst, 2008; Willis and Willis, 2012; Lipp et al., 2012; Schreuer and Weismeier-Sammer, 2010; Weismeier-Sammer and Reiner, 2011). Pioneering examples include EWS in Germany, Enercoop in France, Energy4All in the UK, or Ecopower in Belgium. As these citizen groups tend to adopt the cooperative model, or a related form depending on the local legislation and context, it seems important to understand what are the specific features, assets and limitations of this model in the field of RE. Indeed, while ‘traditional’ cooperatives operating for a long time in fields such as banking, agriculture, or retail, have received an important attention in the cooperative literature, much work still needs to be done to understand why and how cooperatives emerge either in fields in which they have not traditionally been widespread (such as health and care, services, etc.), or in ‘new’ fields or sub-fields (such as fair trade, microfinance or renewable energy). Research is even more needed insofar as ‘new’ cooperatives tend to differ from traditional ones in several ways, for instance through the involvement of multiple stakeholders (rather than a dominant one such as producers, consumers or workers) or through a stronger orientation towards general interest goals (beyond traditional mutual interest at the basis of most cooperatives). While RE cooperatives have strongly developed in countries such as Denmark (Lipp et al., 2012), Germany (Schreuer, 2012; Weismeier-Sammer and Reiner, 2011) and to a lesser extent the UK (Aitken, 2010; Kellett, 2007; Seyfang et al., 2012; van der Horst, 2008; Willis and Willis, 2012; Walker et al., 2007), their development has been much slower in other countries, particularly Southern Europe (Lipp et al., 2012). This seems to echo, to a certain extent, the general development of RE in these countries (Haas et al., 2011). Before mapping these differences against the background of RE development in these countries, it is necessary to understand how the assets and limits of the cooperative model apply to the particular case of RE. This is precisely the aim of this article. On the one hand, the assets of the cooperative model enable to understand why this form has been adopted by citizen groups and has developed in certain countries. On the other hand, the limits or weaknesses of the model enable to explain why cooperatives are still a minority in the field of RE and why their development is constrained by obstacles in certain countries. [less ▲]

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See detailObservation <–> Text(e) <–> Culture. Introduction
Badir, Sémir ULg

in Semiotica (2014), 198

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See detailDie Deutschsprachige Gemeinschaft und die sechste Staatsreform
Behrendt, Christian ULg; Vrancken, Martin ULg

in Europäisches Journal für Minderheitenfragen (2013), Jahr 2013

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See detailDeveloping a Global Food Security Policy
Paveliuc Olariu, Codrin ULg

in Advances in Agriculture & Botanics (2013), 5(3), 169-173

The world agrifood system continues to be in a vulnerable state as we fast approach the 2015 deadline for the Millennium Development Goal of halving the proportion of people suffering from hunger ... [more ▼]

The world agrifood system continues to be in a vulnerable state as we fast approach the 2015 deadline for the Millennium Development Goal of halving the proportion of people suffering from hunger. Although a number of countries have made important changes towards developing food related policies, at the level of the global community, the challenge of food (in)security has not been able push policy makers to develop a common solution to be applied, solution that could include the regional and national specificities registered around the world, while also integrating a global view of increasing agricultural productivity, higher farm competitiveness and without relinquishing the national or individual right for food governance. [less ▲]

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See detailFood scarcity as a trigger for civil unrest
Paveliuc Olariu, Codrin ULg

in Advances in Agriculture & Botanics (2013), 5(3), 174-178

Throughout history, there have been periods of civil unrest. From religious wars to wars of conquest, historians believe that the causes of wars are closely related with religious, political or economic ... [more ▼]

Throughout history, there have been periods of civil unrest. From religious wars to wars of conquest, historians believe that the causes of wars are closely related with religious, political or economic reasons. But when we discuss about civil unrest inside a country with the power of transforming it into a civil war and expanding at regional level, the triggering factors have yet to be discovered. From the period of the Qing Dinasty (1644-1911) in China to the Great Depression in the 1930s in the USA or the beginning of the second World War in France, these periods have two common points: civil unrest and food shortages. [less ▲]

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See detailIs the multicolored Asian ladybeetle, Harmonia axyridis, the most abundant natural enemy to aphids in agroecosystems?
Vandereycken, Axel ULg; Durieux, Delphine ULg; Joie, Emilie ULg et al

in Journal of Insect Science [=JIS] (2013), 13(158), 1-14

The multicolored Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was introduced into Western Europe in the late 1990s. Since the late 2000s, this species has been commonly ... [more ▼]

The multicolored Asian ladybeetle, Harmonia axyridis Pallas (Coleoptera: Coccinellidae), was introduced into Western Europe in the late 1990s. Since the late 2000s, this species has been commonly considered one of the most abundant aphid predators in most Western European coun- tries. In spite of the large amount of research on H. axyridis, information concerning its relative abundance in agroecosystems is lacking. This study aims to evaluate the abundance of H. axyridis within the aphidophage community in four crops situated in southern Belgium: wheat, Triticum aestivum L. (Poales: Poaceae), corn, Zea mays, potato, Solanum tuberosum (Solanales: Solanaceae), and broad bean Vicia faba (Fabales: Fabaceae). In order to assess the species diver- sity, the collected data were analyzed by considering (1) the species richness and (2) the evenness according to the Shannon diversity index. Eleven aphidophages were observed in every invento- ried agroecosystem, including five abundant species: three coccinellids, the seven-spotted ladybug, Coccinella septempunctata L. (Coleoptera: Coccinellidae), the 14-spotted Ladybird, Propylea quatuordecimpunctata, and H. axyridis; one hoverfly, the marmalade hoverfly, Episyr- phus balteatus De Geer (Diptera: Syrphidae); and one lacewing, the common green lacewing, Chrysoperla carnea Stephens sensu lato (= s.l.) (Neuroptera: Chrysopidae). Harmonia axyridis has been observed to thrive, breed, and reproduce on the four studied crops. Harmonia axyridis is the most abundant predator of aphids in corn followed by C. septempunctata, which is the main aphid predator observed in the three other inventoried crops. In wheat and potato fields, H. axyridis occurs in low numbers compared to other aphidophage. These observations suggest that H. axyridis could be considered an invasive species of agrosystems, and that potato and wheat may intermittently act as refuges for other aphidophages vulnerable to intraguild predation by this invader. Harmonia axyridis is not the most abundant aphid predator in the main Belgian crops. [less ▲]

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See detailVerbal overshadowing of face memory does occur in children too!
Dehon, Hedwige ULg; Vanootighem, Valentine ULg; Brédart, Serge ULg

in Frontiers in Psychology (2013)

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See detailAssessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo
Mvumbi, Dieudonné; BOREUX, Raphaël ULg; SACHELI, Rosalie ULg et al

in Malaria Journal (2013), 12

BACKGROUND: In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies ... [more ▼]

BACKGROUND: In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chloroquine (CQ) from its malaria treatment policy in 2002 and an artesunate (AS)-amodiaquine (AQ) combination became the ACT of choice in DRC in 2005. AQ-resistance (AQR) has been reported in several parts of the world and mutations in codons 72-76 of the Plasmodium falciparum chloroquine-resistance transporter (pfcrt) gene have been strongly correlated with resistance, especially mutations encoding the SVMNT haplotype. This haplotype was first identified in Southeast Asia and South America but was recently reported in two African countries neighbouring DRC. These facts raised two questions: the first about the evolution of CQ resistance (CQR) in DRC and the second about the presence of the SVMNT haplotype, which would compromise the use of AQ as a partner drug for ACT. METHODS: A total of 213 thick blood films were randomly collected in 2010 from a paediatric clinic in Kinshasa, DRC. Microscopy controls and real-time polymerase chain reaction (RT-PCR) were performed for Plasmodium species identification. Haplotypes of the pfcrt gene were determined by sequencing. RESULTS: The K76T mutation was detected in 145 out of 198 P. falciparum-positive samples (73.2%).In these 145 resistant strains, only the CVIET haplotype was detected. CONCLUSIONS: This study is the first to assess the molecular markers of resistance to CQ and AQ after the introduction of ACT in DRC. The results suggest first that CQR is decreasing, as wild-type pfcrt haplotypes were found in only 26.8% of the samples and secondly that the SVMNT haplotype is not yet present in Kinshasa, suggesting that AQ remains valid as a partner drug for ACT in this region. [less ▲]

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See detailSémiotique de la communication en co-présence et à distance. Du textualisme à la sémiotique des pratiques
Dondero, Maria Giulia ULg; Angenot, Valérie ULg; Joachim, Guillaume ULg et al

in Interfaces Numériques (2013), 2(3), 531-567

This article aims to challenge and reflect on the theories issued by both textualist semiotics and the semiotics of practices. Our reflexion shall focus, on the one hand, on synchronic communication in ... [more ▼]

This article aims to challenge and reflect on the theories issued by both textualist semiotics and the semiotics of practices. Our reflexion shall focus, on the one hand, on synchronic communication in copresence and, on the other hand, on virtual participative remote collaboration by means of digital interfaces. In high-level collaborative activities —such as remote architectural project developments— the practices of the partners involved in the communication process are conditioned by intrinsic material constraints; they have to gradually readapt to the constantly renewed dynamics of the predicative structures in order to ensure communication efficiency. One of the main purposes of this paper consists in exploring the theoretical propositions and methodologies connected to practices, as proposed by Jacques Fontanille’s semiotics (2008) and by Jacques Theureau’s ergonomics of the “course of action” (2006). The results of these theoretical reflections will be tested through their application to a specific corpus, in an aim to confront the efficiency of such proposals with a case study. Multimodality and the role played by the different types of utterances in the efficiency of communication, as well as the adaptation of the semiotic practices to the digital interfaces also fall under the scope of this paper. Besides, the authors propose a reflection on potential mediations between the ongoing practices and their objectivation through textualisation and notation. [less ▲]

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See detailOn the Encoding of Proteins for Disordered Regions Prediction
Becker, Julien ULg; Maes, Francis; Wehenkel, Louis ULg

in PLoS ONE (2013)

Disordered regions, i.e., regions of proteins that do not adopt a stable three-dimensional structure, have been shown to play various and critical roles in many biological processes. Predicting and ... [more ▼]

Disordered regions, i.e., regions of proteins that do not adopt a stable three-dimensional structure, have been shown to play various and critical roles in many biological processes. Predicting and understanding their formation is therefore a key sub-problem of protein structure and function inference. A wide range of machine learning approaches have been developed to automatically predict disordered regions of proteins. One key factor of the success of these methods is the way in which protein information is encoded into features. Recently, we have proposed a systematic methodology to study the relevance of various feature encodings in the context of disulfide connectivity pattern prediction. In the present paper, we adapt this methodology to the problem of predicting disordered regions and assess it on proteins from the 10th CASP competition, as well as on a very large subset of proteins extracted from PDB. Our results, obtained with ensembles of extremely randomized trees, highlight a novel feature function encoding the proximity of residues according to their accessibility to the solvent, which is playing the second most important role in the prediction of disordered regions, just after evolutionary information. Furthermore, even though our approach treats each residue independently, our results are very competitive in terms of accuracy with respect to the state-of-the-art. A web-application is available at http://m24.giga.ulg.ac.be:81/x3Disorder. [less ▲]

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See detailReintroduction of the invasive mosquito species Aedes albopictus in Belgium in July 2013
Boukraa, Slimane ULg; Raharimalala, Fara Nantenaina ULg; Zimmer, Jean-Yves ULg et al

in Parasite (Paris, France) (2013), 20(54),

Since its first report in 2000, the invasive mosquito Aedes albopictus was not found any more during the different entomological inspections performed at its place of introduction in Belgium between 2001 ... [more ▼]

Since its first report in 2000, the invasive mosquito Aedes albopictus was not found any more during the different entomological inspections performed at its place of introduction in Belgium between 2001 and 2012. In July 2013, one adult male was captured at the same site (a platform of imported used tires located in Vrasene, Oost-Vlaanderen Province), during a monitoring using CO2-baited trap. This finding suggests the reintroduction of the species in Belgium via the used tire trade. [less ▲]

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See detailModeling of Wastewater Sludge Drying with Determination of Diffusivity Moisture
Bennamoun, Lyes ULg; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Journal of Residuals Science and Technology [=JRST] (2013), 10(4), 165

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See detailInfluence of ovarian hormones on cortical spreading depression and its suppression by L-kynurenine in rat.
Chauvel, Virginie ULg; Schoenen, Jean ULg; Multon, Sylvie ULg

in PLoS ONE (2013), 8(12), 82279

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the ... [more ▼]

Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading depression (CSD). We have previously shown that systemic L-kynurenine (L-KYN), the precursor of kynurenic acid, suppresses CSD and that this effect depends on the stage of the estrous cycle in female rats. The objectives here are to determine the influence of ovarian hormones on KCl-induced CSD and its suppression after L-KYN by directly modulating estradiol or progesterone levels in ovariectomized rats. Adult female rats were ovariectomized and subcutaneously implanted with silastic capsules filled with progesterone or 17β-estradiol mixed with cholesterol, with cholesterol only or left empty. Two weeks after the ovariectomy/capsule implantation, the animals received an i.p. injection of L-KYN (300 mg/kg) or NaCl as control. Thirty minutes later CSDs were elicited by applying KCl over the occipital cortex and recorded by DC electrocorticogram for 1 hour. The results show that both estradiol and progesterone increase CSD frequency after ovariectomy. The suppressive effect of L-KYN on CSD frequency, previously reported in normal cycling females, is not found anymore after ovariectomy, but reappears after progesterone replacement therapy. Taken together, these results emphasize the complex role of sex hormones on cortical excitability. The CSD increase by estradiol and, more surprisingly, progesterone may explain why clinically migraine with aura appears or worsens during pregnancy or with combined hormonal treatments. [less ▲]

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See detailLa cloche Lovinfosse du Trésor de la Cathédrale de Liège
Marganne, Marie-Hélène ULg; Mélard, Marc

in Bloc-Notes : Bulletin périodique du Trésor de la Cathédrale de Liège (2013), 37

Examen de la cloche de bronze J.F. Lovinfosse 1818 provenant du Couvent des Filles de la Croix, rue Hors-Château, à Liège, et conservée au Trésor de la Cathédrale de Liège.

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See detailPoly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release
Liu, Ji ULg; Detrembleur, Christophe ULg; Debuigne, Antoine ULg et al

in Nanoscale (2013), 5(23), 11464-11477

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug ... [more ▼]

Original core/corona nanoparticles composed of amaghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment. [less ▲]

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See detailPubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction.
Franssen, Delphine ULg; Ioannou, Yiannis S.; Alvarez-Real, Alexandra et al

in Reproductive toxicology (Elmsford, N.Y.) (2013)

We studied the effects of neonatal exposure to diethylstilbestrol (DES) on pubertal timing in female rats. We examined associated neuroendocrine changes and effects of prenatal food restriction. Age at ... [more ▼]

We studied the effects of neonatal exposure to diethylstilbestrol (DES) on pubertal timing in female rats. We examined associated neuroendocrine changes and effects of prenatal food restriction. Age at vaginal opening was advanced after exposure to 10mug/kg/d of DES and delayed after 1mug/kg/d (subcutaneous injections). Using this lower dose, pulsatile GnRH secretion was slower at 25 days of age. Both doses reduced KiSS1 mRNA levels at 15 days of age. Using functional Kisspeptin promoter assay, 1 or 10muM DES reduced or increased KISS1 transcription, respectively. Leptin stimulatory effect on GnRH secretion in vitro (15 days of age) was reduced after prenatal food restriction and neonatal DES exposure (higher dose), both effects being cumulative. Thus, alterations in pubertal timing by DES neonatally are not unequivocally toward precocity, the level of exposure being critical. We provide evidence of neuroendocrine disruption and interaction with prenatal food availability. [less ▲]

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See detailInversion of a part of the numerator relationship matrix using pedigree information
Faux, Pierre ULg; Gengler, Nicolas ULg

in Genetics, Selection, Evolution [=GSE] (2013), 45

Background. In recent theoretical developments, the information available (e.g. genotypes) divides the original population into two groups: animals with this information (selected animals) and animals ... [more ▼]

Background. In recent theoretical developments, the information available (e.g. genotypes) divides the original population into two groups: animals with this information (selected animals) and animals without this information (excluded animals). These developments require inversion of the part of the pedigree-based numerator relationship matrix that describes the genetic covariance between selected animals (A22). Our main objective was to propose and evaluate methodology that takes advantage of any potential sparsity in the inverse of A22 in order to reduce the computing time required for its inversion. This potential sparsity is brought out by searching the pedigree for dependencies between the selected animals. Jointly, we expected distant ancestors to provide relationship ties that increase the density of matrix A22 but that their effect on A22i might be minor. This hypothesis was also tested. Methods. The inverse of A22 can be computed from the inverse of the triangular factor (T-1 ) obtained by Cholesky root-free decomposition of A22 . We propose an algorithm that sets up the sparsity pattern of T-1 using pedigree information. This algorithm provides positions of the elements of T-1 worth to be computed (i.e. different from zero). A recursive computation of A22i is then achieved with or without information on the sparsity pattern and time required for each computation was recorded. For three numbers of selected animals (4000; 8000 and 12 000), A22 was computed using different pedigree extractions and the closeness of the resulting A22i to the inverse computed using the fully extracted pedigree was measured by an appropriate norm. Results. The use of prior information on the sparsity of T-1 decreased the computing time for inversion by a factor of 1.73 on average. Computational issues and practical uses of the different algorithms were discussed. Cases involving more than 12 000 selected animals were considered. Inclusion of 10 generations was determined to be sufficient when computing A22. Conclusions. Depending on the size and structure of the selected sub-population, gains in time to compute A22 are possible and these gains may increase as the number of selected animals increases. Given the sequential nature of most computational steps, the proposed algorithm can benefit from optimization and may be convenient for genomic evaluations. [less ▲]

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See detailElectroencephalogram approximate entropy influenced by both age and sleep
Lee, Gerick; Fattinger, Sara; Mouthon, Anne-Laure et al

in Frontiers in Neuroinformatics (2013), 7(33),

The use of information-based measures to assess changes in conscious state is an increasingly popular topic. Though recent results have seemed to justify the merits of such methods, little has been done ... [more ▼]

The use of information-based measures to assess changes in conscious state is an increasingly popular topic. Though recent results have seemed to justify the merits of such methods, little has been done to investigate the applicability of such measures to children. For our work, we used the approximate entropy (ApEn), a measure previously shown to correlate with changes in conscious state when applied to the electroencephalogram (EEG), and sought to confirm whether previously reported trends in adult ApEn values across wake and sleep were present in children. Besides validating the prior findings that ApEn decreases from wake to sleep (including wake, rapid eye movement (REM) sleep, and non-REM sleep) in adults, we found that previously reported ApEn decreases across vigilance states in adults were also present in children (ApEn trends for both age groups: wake > REM sleep > non-REM sleep). When comparing ApEn values between age groups, adults had significantly larger ApEn values than children during wakefulness. After the application of an 8 Hz high-pass filter to the EEG signal, ApEn values were recalculated. The number of electrodes with significant vigilance state effects dropped from all 109 electrodes with the original 1 Hz filter to 1 electrode with the 8 Hz filter. The number of electrodes with significant age effects dropped from 10 to 4. Our results support the notion that ApEn can reliably distinguish between vigilance states, with low-frequency sleep-related oscillations implicated as the driver of changes between vigilance states. We suggest that the observed differences between adult and child ApEn values during wake may reflect differences in connectivity between age groups, a factor which may be important in the use of EEG to measure consciousness. [less ▲]

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See detailInactivation of genes coding for mitochondrial Nd7 and Nd9 complex I subunits in Chlamydomonas reinhardtii. Impact of complex I loss on respiration and energetic metabolism.
Massoz, Simon; Larosa, Véronique ULg; Plancke, Charlotte et al

in Mitochondrion (2013)

In Chlamydomonas, unlike in flowering plants, genes coding for Nd7 (NAD7/49kDa) and Nd9 (NAD9/30kDa) core subunits of mitochondrial respiratory-chain complex I are nucleus-encoded. Both genes possess all ... [more ▼]

In Chlamydomonas, unlike in flowering plants, genes coding for Nd7 (NAD7/49kDa) and Nd9 (NAD9/30kDa) core subunits of mitochondrial respiratory-chain complex I are nucleus-encoded. Both genes possess all the features that facilitate their expression and proper import of the polypeptides in mitochondria. By inactivating their expression by RNA interference or insertional mutagenesis, we show that both subunits are required for complex I assembly and activity. Inactivation of complex I impairs the cell growth rate, reduces the respiratory rate, leads to lower intracellular ROS production and lower expression of ROS scavenging enzymes, and is associated to a diminished capacity to concentrate CO2 without compromising photosynthetic capacity. [less ▲]

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See detailOn protocols and measures for the validation of supervised methods for the inference of biological networks
Schrynemackers, Marie ULg; Kuffner, Robert; Geurts, Pierre ULg

in Frontiers in genetics (2013), 4(262),

Networks provide a natural representation of molecular biology knowledge, in particular to model relationships between biological entities such as genes, proteins, drugs, or diseases. Because of the ... [more ▼]

Networks provide a natural representation of molecular biology knowledge, in particular to model relationships between biological entities such as genes, proteins, drugs, or diseases. Because of the effort, the cost, or the lack of the experiments necessary for the elucidation of these networks, computational approaches for network inference have been frequently investigated in the literature. In this paper, we examine the assessment of supervised network inference. Supervised inference is based on machine learning techniques that infer the network from a training sample of known interacting and possibly non-interacting entities and additional measurement data. While these methods are very effective, their reliable validation in silico poses a challenge, since both prediction and validation need to be performed on the basis of the same partially known network. Cross-validation techniques need to be specifically adapted to classification problems on pairs of objects. We perform a critical review and assessment of protocols and measures proposed in the literature and derive specific guidelines how to best exploit and evaluate machine learning techniques for network inference. Through theoretical considerations and in silico experiments, we analyze in depth how important factors influence the outcome of performance estimation. These factors include the amount of information available for the interacting entities, the sparsity and topology of biological networks, and the lack of experimentally verified non-interacting pairs. [less ▲]

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See detailPreliminary description of the diet of Hippopotamus amphibius L. in Loango National Park (Gabon)
Michez, Adrien ULg; Doucet, Jean-Louis ULg; Dendocker, Nicolas et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(4),

Due to the paucity of suitable habitat, hippos are very rare in the Congo Bassin. Compared to East-African populations, Central African populations of hippos have been less studied. Information found in ... [more ▼]

Due to the paucity of suitable habitat, hippos are very rare in the Congo Bassin. Compared to East-African populations, Central African populations of hippos have been less studied. Information found in the literature regarding the animal’s basic ecology is limited. This study focuses on the description of the diet of an isolated hippo population in Loango National Park (Gabon), comparing faecal analysis with a reference collection ofherbaceous species from the savannas. The effectiveness of using faecal analysis versus using the floristic description of hippos’ pastures was demonstrated. The most frequent herbaceous species identified in faeces samples were Paspalum vaginatum, Axonopus compressus, Stenotaphrum secundatum (Poaceae) and Desmodium triflorum (Fabaceae). The voluntary consumption of a dicotyledonous species (Desmodium triflorum) is novel for this species. [less ▲]

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See detailWR 138: new results from X-ray and optical spectroscopy
Palate, Matthieu ULg; Rauw, Grégor ULg; De Becker, Michaël ULg et al

in Astronomy and Astrophysics (2013), 560

Massive-binary evolution models predict that some systems will go through an evolutionary phase where the original primary has become a supernova and left a compact object behind that then orbits a Wolf ... [more ▼]

Massive-binary evolution models predict that some systems will go through an evolutionary phase where the original primary has become a supernova and left a compact object behind that then orbits a Wolf-Rayet (WR) star. WR 138 is an X-ray bright WR star that has been described as a triple system, including a compact companion in a short-period orbit. Our goal is to search for spectroscopic evidence of a compact companion around WR 138. We used optical and X-ray spectra to search for signatures of a compact companion, which can be revealed by systematic variations in WR optical spectral lines induced by orbital motion of the compact companion or by hard, luminous X-rays from accretion onto this companion. The optical spectra display emission-line profile variations that are most probably caused by clumps inside the stellar winds. The radial velocities do not vary on a short time-scale compatible with the suggested orbital period of a putative compact companion. The X-ray spectra are found to be normal for a WN5-6+OB system with no indication of accretion by a compact companion. There is no evidence for the presence of a compact companion, and we therefore conclude that WR 138 is a normal long-period (P ~ 1521 d) eccentric WR+OB system. [less ▲]

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See detailLa Deuxième Guerre mondiale aurait-elle eu un impact sur la population rwandaise? Regard sur l'historiographie de ce tournant historique
Singiza, Dantès ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2013), Numéro 4

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See detailPhysical properties and transmission spectrum of the WASP-80 planetary system from multi-colour photometry
Mancini, L.; Southworth, J.; Ciceri, S. et al

in Astronomy and Astrophysics (2013), 1312

WASP-80 is one of only two systems known to contain a hot Jupiter which transits its M-dwarf host star. We present eight light curves of one transit event, obtained simultaneously using two defocussed ... [more ▼]

WASP-80 is one of only two systems known to contain a hot Jupiter which transits its M-dwarf host star. We present eight light curves of one transit event, obtained simultaneously using two defocussed telescopes. These data were taken through the Bessell I, Sloan griz and near-infrared JHK passbands. We use our data to search for opacity-induced changes in the planetary radius, but find that all values agree with each other. Our data are therefore consistent with a flat transmission spectrum to within the observational uncertainties. We also measure an activity index of the host star of log R'_HK=-4.495, meaning that WASP-80A shows strong chromospheric activity. The non-detection of starspots implies that, if they exist, they must be small and symmetrically distributed on the stellar surface. We model all available optical transit light curves to obtain improved physical properties and orbital ephemerides for the system. [less ▲]

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See detailA Photometric Study of the Hot Exoplanet WASP-19b
Lendl, M.; Gillon, Michaël ULg; Queloz, D. et al

in Astronomy and Astrophysics (2013), 552

Context. The sample of hot Jupiters that have been studied in great detail is still growing. In particular, when the planet transits its host star, it is possible to measure the planetary radius and the ... [more ▼]

Context. The sample of hot Jupiters that have been studied in great detail is still growing. In particular, when the planet transits its host star, it is possible to measure the planetary radius and the planet mass (with radial velocity data). For the study of planetary atmospheres, it is essential to obtain transit and occultation measurements at multiple wavelengths. Aims: We aim to characterize the transiting hot Jupiter WASP-19b by deriving accurate and precise planetary parameters from a dedicated observing campaign of transits and occultations. Methods: We have obtained a total of 14 transit lightcurves in the r'-Gunn, I-Cousins, z'-Gunn, and I + z' filters and 10 occultation lightcurves in z'-Gunn using EulerCam on the Euler-Swiss telescope and TRAPPIST. We also obtained one lightcurve through the narrow-band NB1190 filter of HAWK-I on the VLT measuring an occultation at 1.19 μm. We performed a global MCMC analysis of all new data, together with some archive data in order to refine the planetary parameters and to measure the occultation depths in z'-band and at 1.19 μm. Results: We measure a planetary radius of Rp = 1.376 ± 0.046 RJ, a planetary mass of Mp = 1.165 ± 0.068 MJ, and find a very low eccentricity of e = 0.0077-0.0032+0.0068, compatible with a circular orbit. We have detected the z'-band occultation at 3σ significance and measure it to be δFocc,z' = 352 ± 116 ppm, more than a factor of 2 smaller than previously published. The occultation at 1.19 μm is only marginally constrained at δFocc,NB1190 = 1711-726+745 ppm. Conclusions: We show that the detection of occultations in the visible range is within reach, even for 1 m class telescopes if a considerable number of individual events are observed. Our results suggest an oxygen-dominated atmosphere of WASP-19b, making the planet an interesting test case for oxygen-rich planets without temperature inversion. [less ▲]

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See detailEarly-type stars observed in the ESO UVES Paranal Observatory Project - IV. Studies of CN, CH+ and CH in the interstellar medium
Smoker, J.; Ledoux, C.; Jehin, Emmanuel ULg et al

in Monthly Notices of the Royal Astronomical Society (2013)

High spectral resolution (˜80 000) and signal-to-noise observations from the Ultraviolet and Visual Echelle Spectrograph Paranal Observatory Project (UVES-POP) are used to study the interstellar molecular ... [more ▼]

High spectral resolution (˜80 000) and signal-to-noise observations from the Ultraviolet and Visual Echelle Spectrograph Paranal Observatory Project (UVES-POP) are used to study the interstellar molecular lines CN (3874 Å), CH[SUP]+[/SUP] (3957, 4232 Å) and CH (3886, 4300 Å) towards 74 O- and B-type stellar sightlines. Additionally, archive data are presented for 140 ELODIE early-type stellar sightlines at R = 42 000, plus 25 FEROS at R = 48 000 and 3 UVES at R > 50 000, mainly in the CH[SUP]+[/SUP] (4232 Å) and CH (3886, 4300 Å) transitions. Detection rates are ˜45 per cent for CN and ˜67 per cent for the other lines in the POP sample, and ˜10-15 per cent for CH[SUP]+[/SUP] and CH lines in the additional sample. CH and CH[SUP]+[/SUP] are well correlated between log[N(CH) cm[SUP]-2[/SUP]]˜12-14, implying that these clouds are CH[SUP]+[/SUP]-like CH and not CN-like CH. CH is also very well correlated with Na I D in the range log[N(Na I cm[SUP]-2[/SUP]]) ˜12.2-14.2. A few sightlines show tentative velocity shifts of ˜2 km s[SUP]-1[/SUP] between CH and CH[SUP]+[/SUP], which appear to be caused by differences in component strength in blends, and hence do not provide firm evidence for shocks. Finally, we describe a search for [SUP]13[/SUP]CH[SUP]+[/SUP] in a sightline towards HD 76341. No [SUP]13[/SUP]CH[SUP]+[/SUP] is detected, placing a limit on the [SUP]13[/SUP]CH[SUP]+[/SUP] to [SUP]12[/SUP]CH[SUP]+[/SUP] ratio of ˜0.01. If a formal fit is attempted, the equivalent width ratio in the two isotopes is a factor ˜90 but with large errors. [less ▲]

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See detailConstructing practice on evolutionary knowledge in ECEC
Pirard, Florence ULg

in Nordisk Barnehageforskning 2013 (Nordic Early Childhood Education Research) (2013), 6(28), 1-7

This article provides a discussion on the importance of knowledge in early childhood education and also the role of knowledge dissemination process in the field. From the question of giving more freedom ... [more ▼]

This article provides a discussion on the importance of knowledge in early childhood education and also the role of knowledge dissemination process in the field. From the question of giving more freedom of movement, knowledge about this topic used in a Belgian curriculum, the article illustrates the importance of considering practice not as an application of theory, but as a co-construct and complex process that combines it with other resources in context. It illustrates the importance of going further than the production of knowledge to create appropriate practice in service. [less ▲]

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See detailThe X-ray under-luminosity of the O-type supergiants HD16691 and HD14947 revealed by XMM-Newton
De Becker, Michaël ULg

in New Astronomy (2013), 25

The members of the scarce category of Of^+ supergiants present properties that are intermediate between regular O-stars and Wolf-Rayet (WR) stars. Significant similarities between these transitional stars ... [more ▼]

The members of the scarce category of Of^+ supergiants present properties that are intermediate between regular O-stars and Wolf-Rayet (WR) stars. Significant similarities between these transitional stars and WN-type objects are now clearly established, at least in the visible and near-infrared domains, pointing to common stellar wind properties. In this study, we report on the first dedicated X-ray observations of HD16691 (O4If^+) and HD14947 (O5f^+), revealing a soft thermal spectrum in agreement with the expected X-ray emission from a single O-type star. However, the X-ray luminosity of our targets is slightly lower than expected for single O-type stars, suggesting that the particular properties of their stellar wind has also a significant impact on the X-ray emission of these objects on the way to the WN category. We argue that the X-ray under-luminosity of HD16691 and HD14947 may be interpreted as the signature in X-rays of the intermediate stage between O and WR stars, as a consequence of enhanced wind density. [less ▲]

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See detailAnnual variation in neustonic micro- and meso-plastic particles and zooplankton in the Bay of Calvi (Mediterranean–Corsica)
Collignon, Amandine ULg; Hecq, Jean-Henri ULg; Galgani, François et al

in Marine Pollution Bulletin (2013)

The annual variation in neustonic plastic particles and zooplankton was studied in the Bay of Calvi 23 (Corsica) between 30 August 2011 and 7 August 2012. Plastic particles were classified into three size ... [more ▼]

The annual variation in neustonic plastic particles and zooplankton was studied in the Bay of Calvi 23 (Corsica) between 30 August 2011 and 7 August 2012. Plastic particles were classified into three size classes, small microplastics (0.2–2 mm), large microplastics (2–5 mm) and mesoplastics (5–10 mm). 74% of the 38 samples contained plastic particles of varying composition: e.g. filaments, polystyrene, thin plastic films. An average concentration of 6.2 particles/100 m2 was observed. The highest abundance values (69 particles/100 m2) observed occurred during periods of low offshore wind conditions. These values rose in the same order of magnitude as in previous studies in the North Western Mediterranean. The relationships between the abundance values of the size classes between zooplankton and plastic particles were then examined. The ratio for the intermediate size class (2–5 mm) reached 2.73. This would suggest a potential confusion for predators regarding planktonic prey of this size class. [less ▲]

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See detailNew developments in artificially layered ferroelectric oxide superlattices
Dawber, Matthew; Bousquet, Eric ULg

in MRS Bulletin (2013), 38

Artifi cially layered superlattices of oxide materials have been intensely investigated for some time, but continue to reveal new potential as a route to advanced functional materials. As well as ... [more ▼]

Artifi cially layered superlattices of oxide materials have been intensely investigated for some time, but continue to reveal new potential as a route to advanced functional materials. As well as considering electrostatics and strain, a more complete picture of the interfaces in these systems also needs to incorporate the possibility of additional structural distortions, electronic redistributions, and complex polarization domain structures. Here we focus on superlattices composed of two perovskite oxide materials, where one is a ferroelectric, and discuss the important interactions between the component materials that determine the behavior of the new artifi cial material. We discuss interfaces both with and without electronic screening. The fi rst class of interface contains technologically relevant ultrathin ferroelectric capacitors and the more recently studied ferroelectric-metal superlattices. In these systems, the infl uence of the ferroelectric polarization decreases rapidly with distance from the interface. By contrast, in systems where the materials adjacent to the ferroelectric layers are dielectrics, the polarization of the ferroelectric layer infl uences the properties of the adjacent layers over a much longer distance, setting the stage for fascinating competition between the properties of the combined materials. [less ▲]

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See detailConnection between cardiac vascular permeability, myocardial oedema and inflammation during sepsis: role of the alpha1AMPK isoform
Castanares-Zapatero, Diego; Bouleti, C; Sommereyns, C et al

in Critical Care Medicine (2013), 41(12), 411-22

Objective: Since AMP-activated protein kinase (AMPK) both controls cytoskeletonorganization in endothelial cells (ECs) and exerts anti-inflammatory effects, we here postulated that it could influence ... [more ▼]

Objective: Since AMP-activated protein kinase (AMPK) both controls cytoskeletonorganization in endothelial cells (ECs) and exerts anti-inflammatory effects, we here postulated that it could influence vascular permeability and inflammation, thereby counteracting cardiac wall oedema during sepsis. Design: Controlled animal study Settings: University research laboratory Subjects: C57BL/6J, α1AMPK-/- and α1AMPK+/+ mice Intervention: Sepsis was triggered in vivo using a sub-lethal injection of lipopolysaccharide (LPS, O55B5, 10 mg.kg-1), inducing systolic left ventricular (LV) dysfunction. LV function, oedema, vascular permeability and inflammation were assessed in vivo in both wild type (WT) mice (α1AMPK+/+) and α1AMPK-deficient mice (α1AMPK-/-). 5-Aminoimidazole-4-carboxamide riboside (AICAr) served to study the impact of AMPK activation on vascular permeability in vivo. The integrity of EC monolayers was also examined in vitro after LPS challenge in the presence of AICAr and/or after α1AMPK silencing. Measurements and main results: α1AMPK-deficiency dramatically impaired tolerance to LPS challenge. Indeed, α1AMPK-/- exhibited heightened cardiac vascular permeability after LPS challenge compared to α1AMPK+/+. Consequently, an increase in LV mass corresponding to exaggerated wall oedema occurred in α1AMPK-/-, without any further decrease in systolic function. Mechanistically, the LPS-induced α1AMPK-/- cardiac phenotype could not be attributed to major changes in the systemic inflammatory response, but was due to an increased disruption of interendothelial tight junctions. Accordingly, AMPK activation by AICAr counteracted LPS-induced hyperpermeability in WT mice in vivo as well as in ECs in vitro. This effect was associated with a potent protection of ZO-1 linear border pattern in ECs. Conclusions: Our results demonstrate, for the first time the involvement of a signalling pathway in the control of LV wall oedema during sepsis. AMPK exerts a protective action through the preservation of interendothelial tight junctions. Interestingly, exaggerated LV wall oedema was not coupled with aggravated systolic dysfunction. However, it could contribute to diastolic dysfunction in septic patients. [less ▲]

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See detailLa cascade des MAP kinases : traitements ciblés en cancérologie cutanée.
PIERARD, Gérald ULg; Franchimont, Claudine ULg; LEONARD, Boris ULg et al

in Revue Médicale de Liège (2013), 68(12), 650-654

Résumé : Les «Mitogen-Activated Protein Kinases» (MAPK) forment un ensemble coordonné de protéines cellulaires impliquées dans la prolifération, la différenciation, la migration et l’apoptose des cellules ... [more ▼]

Résumé : Les «Mitogen-Activated Protein Kinases» (MAPK) forment un ensemble coordonné de protéines cellulaires impliquées dans la prolifération, la différenciation, la migration et l’apoptose des cellules. Elles sont particulièrement activées, par certaines cytokines, hormones, le stress environnemental, ainsi que dans des cancers cutanés. Des agents pharmacologiques ciblés contre la cascade MAPK révolutionnent actuellement la cancérologie cutanée, du moins dans une phase transitoire du processus métastatique. Des traitements combinés sont susceptibles d’améliorer la survie médiane. [less ▲]

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See detailDiagnosis of the transport of adsorbed material in the Scheldt estuary: A proof of concept
Delhez, Eric ULg; Wolk, Frank ULg

in Journal of Marine Systems (2013), 128

Many contaminants can attach to suspended particles. Their transport differs therefore from the transport of dissolved substances, especially in highly turbid environment like estuaries. In this paper, we ... [more ▼]

Many contaminants can attach to suspended particles. Their transport differs therefore from the transport of dissolved substances, especially in highly turbid environment like estuaries. In this paper, we show how the Constituent Age and Residence time Theory (CART — www.climate.be/CART) can be adapted to quantify in a rigorous manner the transport rate of contaminants that are present in both the dissolved and adsorbed phases. On the basis of numerical experiment using a 1D model of the Scheldt estuary, it is shown that the interaction with suspended particles significantly affects the transport of contaminants with partition coefficients larger than 1000 ml/g. The mean transit time from Ghent to Vlissingen of such contaminants can reach 160 days while it is only 60 days for water and dissolved constituents. This increase of the transit time is mainly due to the fact that adsorbed constituents spend long periods of time on the bottom. Surprisingly, the downstream transport of adsorbed constituents in the water column appears more effective than that of dissolved constituents. This transport affects however a small fraction of the adsorbed constituent and is therefore not sufficient to compensate for the long resting phase on the bottom of the bulk of the constituent. The concept and methodology introduced in this paper are easily applicable to most model studies and provide powerful and flexible tools for the detailed understanding of the transport of contaminants in estuaries. In particular, the concept of age and modified ages taking into account specifically the time spent in the water column or in the bottom provide new diagnostic tools to understand and quantify the dynamics of contaminants. [less ▲]

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See detailCe cavernome cérébral est-il la cause d'un syndrome parkinsonien ?
Benmouna, Karim; DIVE, Dominique ULg; WANG, François-Charles ULg et al

in Revue Médicale de Liège (2013), 68(12), 613-616

We report the case of a patient presenting with an akineto-rigid syndrome of the left hemibody whose etiological exploration by magnetic resonance imaging showed the presence of a cavernoma located in the ... [more ▼]

We report the case of a patient presenting with an akineto-rigid syndrome of the left hemibody whose etiological exploration by magnetic resonance imaging showed the presence of a cavernoma located in the right lenticular region. The interest of this situation lies in establishing whether pathophysiological link may exist between such symptoms and the lesion. [less ▲]

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See detailAbundance estimates of southern right whales (Eubalaena australis) in Bahía San Antonio, Patagonia, Argentina
Vermeulen, Els ULg

in Journal of Cetacean Research and Management (2013), 13

The abundance of southern right whales (Eubalaena australis) was estimated by the means of aerial line-transect surveys for the area of Bahía San Antonio, a bay located in the north-western region of the ... [more ▼]

The abundance of southern right whales (Eubalaena australis) was estimated by the means of aerial line-transect surveys for the area of Bahía San Antonio, a bay located in the north-western region of the San Matías Gulf (40°50’S 64°50’W), Rio Negro, Patagonia Argentina. In total, seven aerial surveys were conducted in the first week of August and September 2009, September, October and November 2010, and August, September 2011. Survey effort equalled a total flight time of 12.4h, during which 200 whales were counted in 119 whale groups. Half of the encounters were solitary animals and 17% were mating groups. Corrected abundance estimates showed the highest amount of whales present in the bay during the month of September, with 85±71, 207±108 and 117±55 animals in 2009, 2010 and 2011 respectively. In adjacent months, less than half the amount of whales seemed to be present. The correction factor g(0)availability resulted 0.392±0.456. Perception bias was not accounted for. These aerial surveys resulted in the first estimates of southern right whale abundance in this north Patagonian bay and indicated a rather abrupt peak during the month of September. This being the peak month for right whale presence is consistent with data from other regions in the Southwest Atlantic, but data obtained in the other months remained scarce and thus results should be interpreted carefully. The complete absence of whales in the area during November 2010 and August 2011 raises further questions on the predictability of the whale’s presence in the area. Overall, more consistent aerial surveys should be conducted to accurately determine the annual and interannual evolution of southern right whale abundance in the study area. [less ▲]

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See detailPeut-on avoir plusieurs pensées en même temps ? Étude d’une controverse scolaire et de son traitement par Descartes dans L’Entretien avec Burman
Dubouclez, Olivier ULg

in UBB Studia. Philosophia (2013), 58(3), 85-108

According to Burman, Descartes’ proof of the existence of God in the Third Meditation depends on the reader’s ability to attend to several axioms at the same time. However it is a claim endorsed by a wide ... [more ▼]

According to Burman, Descartes’ proof of the existence of God in the Third Meditation depends on the reader’s ability to attend to several axioms at the same time. However it is a claim endorsed by a wide range of Aristotelian schoolmen and by Burman after them that such a simultaneous conception is far beyond the capacity of our mind. Descartes takes an original stand in that controversy : human thought is a temporal process in which ideas not only succeed but also interfere with one another ; meditation can help stretching our attention so as to embrace more than one argument in a same moment. Indeed, metaphysics is not only a matter of order for Descartes, but also of synoptical power. [less ▲]

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See detailRhétorique visuelle et énonciation
Dondero, Maria Giulia ULg

in Visible (2013), 10

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See detailLa magie et la sorcellerie des visages comme socle anthropologique de la philosophie sartrienne
Englebert, Jérôme ULg

in Etudes Sartriennes (2013), 17

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à ... [more ▼]

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à un troisième axe, intermédiaire : celui du visage ou, plutôt, des visages. La thèse de ce court essai tient à considérer que la phénoménologie sartrienne a déjà réalisé ce travail de fond qui requiert, pour le rendre explicite, articulation simple et ordonnancement. [less ▲]

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See detailAnisotropy preserving DTI processing
Collard, Anne ULg; Bonnabel, Silvère; Phillips, Christophe ULg et al

in International Journal of Computer Vision (2013)

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See detailDo Board Characteristics Affect Information Asymmetry?
Sougné, Danielle ULg; Laouti, Mhamed; Ajina, Aymen

in International Journal of Academic Research in Business and Social Sciences (2013), 3(12), 660-675

In this paper, we investigate the empirical relationship between corporate governance and information asymmetry across a range of French firms. Based on a cross-sectional analysis, our study of the ... [more ▼]

In this paper, we investigate the empirical relationship between corporate governance and information asymmetry across a range of French firms. Based on a cross-sectional analysis, our study of the empirical relationship between corporate governance and information asymmetry involved 160 companies over the years 2008-2010. Mechanisms of corporate governance include the characteristics of the board of directors. Our results seem to indicate a significant relationship between certain mechanisms of corporate governance and the information asymmetry of the French market. These mechanisms can reduce adverse selection costs, and make exchanges more transparent. These results suggest that firms with efficient corporate governance mechanisms may reduce informative asymmetry and improve transparency between investors. [less ▲]

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See detailPerformances of Volume Phase Holographic grating for space applications: study of the radiation effect
Loicq, Jerôme ULg; Georges, Marc ULg; Stockman, Yvan ULg et al

in Journal of Applied Physics (2013), 52(34),

The special properties of volume phase holographic gratings make them promising candidates for spectrometry applications where high spectral resolution, low levels of straylight, and low polarization ... [more ▼]

The special properties of volume phase holographic gratings make them promising candidates for spectrometry applications where high spectral resolution, low levels of straylight, and low polarization sensitivity are required. Therefore it is of interest to assess the maturity and suitability of volume phase holographic gratings as enabling technologies for future space missions, with demanding requirements for spectrometry. One of the main areas of research is related to grating ageing under space radiation. In the present paper, two volume grating technologies are analyzed and compared under gamma irradiation. The performances of both technologies, the photo–thermo–refractive glass and the Dichromated Gelatin, are tested on samples and assessed in the and near-infrared bands. The diffraction efficiency degradation under gamma irradiation is assessed. [less ▲]

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See detailA genome scan conducted in a multigenerational pedigree with convergent strabismus supports a complex genetic determinism.
GEORGES, Anouk ULg; Cambisano, Nadine ULg; Ahariz, Naïma ULg et al

in PloS one (2013), 8(12), 83574

A genome-wide linkage scan was conducted in a Northern-European multigenerational pedigree with nine of 40 related members affected with concomitant strabismus. Twenty-seven members of the pedigree ... [more ▼]

A genome-wide linkage scan was conducted in a Northern-European multigenerational pedigree with nine of 40 related members affected with concomitant strabismus. Twenty-seven members of the pedigree including all affected individuals were genotyped using a SNP array interrogating > 300,000 common SNPs. We conducted parametric and non-parametric linkage analyses assuming segregation of an autosomal dominant mutation, yet allowing for incomplete penetrance and phenocopies. We detected two chromosome regions with near-suggestive evidence for linkage, respectively on chromosomes 8 and 18. The chromosome 8 linkage implied a penetrance of 0.80 and a rate of phenocopy of 0.11, while the chromosome 18 linkage implied a penetrance of 0.64 and a rate of phenocopy of 0. Our analysis excludes a simple genetic determinism of strabismus in this pedigree. [less ▲]

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See detailEBP : grille de mots croisés
Durieux, Nancy ULg; Martinez Perez, Trecy ULg

in Cahiers de l'ASELF (2013), 10(4), 30-3136

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See detailRetour d'expérience sur le robot de traite mobile
Lessire, Françoise ULg; Knapp, Emilie ULg; Dufrasne, Isabelle ULg

in Point Vétérinaire (2013), 341

Using a mobile robot to milk grazing cows influences their milk yield. Several factors influencing mik production are described in this paper as is their relative impact on the production.

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See detailEffect of different kinds of anoxia/reoxygenation on the mitochondrial function and the free radicals production of cultured primary equine skeletal myoblasts.
Ceusters, Justine ULg; Mouithys-Mickalad, Ange ULg; Franck, Thierry ULg et al

in Research in Veterinary Science (2013), 95

Horses are outstanding athletes, performing in many different disciplines involving different kinds of efforts and metabolic responses. Depending on exercise intensity, their skeletal muscle oxygenation ... [more ▼]

Horses are outstanding athletes, performing in many different disciplines involving different kinds of efforts and metabolic responses. Depending on exercise intensity, their skeletal muscle oxygenation decreases, and the reperfusion at cessation of the exercise can cause excessive production of free radicals. This study on cultured primary equine myoblasts investigated the effect of different kinds of anoxia/reoxygenation (A/R) on routine respiration, mitochondrial complex I specific activity and free radicals production. Our data revealed that short cycles of A/R caused a decrease of all the parameters, opposite to what a single long period of anoxia did. A preconditioning-like effect could explain our first pattern of results whereas mild uncoupling could be more appropriate for the second one. Anyway, it seems that mitochondrial complex I could play a major role in the regulation of the balance between metabolic and antioxidant protection of the muscular function of athletic horses. [less ▲]

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See detailTransmitive spectral SPR droplet biosensing: principle, sensor design and experimental demonstration
Hastanin, Juriy ULg; Lenaerts, Cedric ULg; Fleury-Frenette, Karl ULg et al

in Plasmonics (2013)

Surface Plasmons Resonance (SPR) architectures based on grating coupler/disperser combination is an attractive alternative for spectral-based biochemical sensing. In this paper, we investigate ... [more ▼]

Surface Plasmons Resonance (SPR) architectures based on grating coupler/disperser combination is an attractive alternative for spectral-based biochemical sensing. In this paper, we investigate theoretically and experimentally a new concept where the plasmon coupling occurs through a thin film grating and sensing occurs via the first evanescent diffraction order in transmitive mode. The surface plasmon wave excitation induces a peak in the wavelength as well as in the angular spectra of the detected first transmitted diffraction order. Accordingly, a change in SPR spectrum of the detected diffraction order can be used to quantify the amount of the target molecules immobilized on the sensor surface and therefore, the concentration of these molecules in the analyte solution. The developed sensor architecture is dedicated to droplet biochemical sensing and appears to be especially suitable for biosensor integration and miniaturization. The presented sensor concept is perfectly suited for mass production of low-cost and reproducible SPR sensor chip for biochemical analysis. The implemented setup gives access to multichannel biosensing with the potential for efficient internal referencing, essential to achieve sufficiently high reproducibility and accuracy of the measurements. [less ▲]

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See detailUn siècle de physiognomonie
Stienon, Valérie ULg; Wicky, Érika

in Etudes Françaises (2013), 49(3), 5-14

Produit syncrétique et protéiforme d’une très longue histoire, la physiognomonie remonte au moins au Pseudo-Aristote (IVe-IIIe siècle av. J.-C.). Très tôt, l’essentiel est déjà posé : il s’agit de ... [more ▼]

Produit syncrétique et protéiforme d’une très longue histoire, la physiognomonie remonte au moins au Pseudo-Aristote (IVe-IIIe siècle av. J.-C.). Très tôt, l’essentiel est déjà posé : il s’agit de considérer les manifestations physiques de l’âme. À la faveur des XVIe et XVIIe siècles, cette étude se précise avec l’association de telle détermination somatique à telle spécificité de caractère, fondant l’explication des moeurs des hommes par des traits corporels considérés comme autant de signes à interpréter. Une distinction vient ensuite faire le départ entre les caractéristiques fixes du corps et du caractère, et leurs aspects mutables. À la fin du XVIIIe siècle, sous l’influence du sensualisme et après l’étude des passions qui avait occupé le siècle classique, cette distinction fonde la séparation entre une physiognomonie au sens restreint et une pathognomonie consacrée à l’étude des signes physiques traduisant le caractère en mouvement et les signes fugitifs de l’expression humaine. La suite de cette histoire, au XIXe siècle, fait l’objet du présent numéro d’Études françaises, qui remet en perspective les formes et les influences de la physiognomonie à ce moment stratégique de son développement. Le bouleversement des hiérarchies socio-culturelles et l’industrialisation des objets socialement distinctifs (vêtements, bijoux, cannes, ombrelles, etc.) ont certainement contribué à accentuer l’intérêt pour la physiognomonie en rendant indispensable la maîtrise d’un certain savoir social. Mais l’engouement qu’elle suscite se caractérise surtout, à ce moment, par la création de foyers institutionnels spécifiques qui la dotent d’un ancrage dans des associations scientifiques, des cercles intellectuels et des organes de presse. Il s’agira donc, indissociablement, de comprendre les raisons d’un succès et d’examiner les reconfigurations d’un héritage. [less ▲]

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See detail125 ans de logement social
Frankignoulle, Pierre ULg

in Architrave (2013), 178

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See detailAnalyse des perspectives de rentabilité de la culture extensive de Jatropha curcas L. dans la zone agroécologique de transition orientale du Sénégal : cas de la communauté rurale de Dialacoto
Terren, Marieke ULg; Cissé, Chérif; Mergeai, Guy ULg

in Cahiers d'Etudes et de Recherches Francophones. Agricultures (2013), 22(6), 568-574

The profitability prospects of the three main modes of extensive cultivation of Jatropha curcas L. in the Rural Community of Dialacoto were studied on 24 farms from 2008 to 2012. In the best tended ... [more ▼]

The profitability prospects of the three main modes of extensive cultivation of Jatropha curcas L. in the Rural Community of Dialacoto were studied on 24 farms from 2008 to 2012. In the best tended peasant plantations aged four or five years the dry seed yield obtained in sole cropping was less than 200 kg/ha. Under these conditions, it is very unlikely that the yield achieved in sole cropping exceeds 800 kg/ha in full production. The average yield per meter of live fences older than fifteen years was 0.9 kg/m. Considering the purchase price of jatropha seeds in 2012 in Senegal (65 F CFA/kg – 0.1 euro/kg), and given the bad productivity and the low precocity of the available planting material, the cultivation of jatropha (as a sole crop or in intercropping) is far less profitable than the main cropping system practiced in the region (groundnut/pearl millet/sorghum/cotton rotation with input application). Any improvement in the economic performance of the production of jatropha seeds requires the selection of varieties that are early, hardy and productive. The establishment of living hedges is for the moment the only installation method that can be recommended to farmers. In addition to providing supplementary income related to seed harvest, hedgerows provide different non-monetary benefits appreciated by farmers: land demarcation, soil protection against wind and water erosion, improved soil water balance and windbreak effect favourable to crop development, crop protection against wandering ruminants, and enclosure for the cattle. [less ▲]

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See detailStiefbroeders. Zuid-Nederlandse letteren en natievorming onder Willem I, 1814-1834
Steyaert, Kris ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2013), 129(4),

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See detailLocal head-loss coefficient at the rectangular transition from a free-surface channel to a conduit
Van Nam, Nguyen; Archambeau, Pierre ULg; Dewals, Benjamin ULg et al

in Journal of Hydraulic Engineering (2013), 139(12), 1318-1323

Experimental tests have been performed to observe and determine, in stationary flow conditions, the local head loss at the transition from a free surface channel to a conduit. These investigations ... [more ▼]

Experimental tests have been performed to observe and determine, in stationary flow conditions, the local head loss at the transition from a free surface channel to a conduit. These investigations considered a wide range of discharge and varied dimensions and positions of a rectangular cross section conduit connected to the downstream extremity of a rectangular free surface channel. From the head loss evaluation results, simple analytical expressions to predict the local head loss coefficient value at the rectangular transition from a channel to a conduit are proposed and validated. [less ▲]

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See detailBreeding sites and species association of the main Bluetongue and Schmallenberg virus vectors, the Culicoides species (Diptera: Ceratopogonidae), in northern Europe
Zimmer, Jean-Yves ULg; Losson, Bertrand ULg; Saegerman, Claude ULg et al

in Annales de la Société Entomologique de France (2013), 49(3), 335-344

Several species of Culicoides (Diptera: Ceratopogonidae) biting midges are biological vectors of bluetongue virus (BTV) and, as recently discovered, Schmallenberg virus (SBV) in northern Europe. Since ... [more ▼]

Several species of Culicoides (Diptera: Ceratopogonidae) biting midges are biological vectors of bluetongue virus (BTV) and, as recently discovered, Schmallenberg virus (SBV) in northern Europe. Since their recent emergence in this part of the continent, these diseases that affect domestic and wild ruminants have caused considerable economic losses to the sheep and cattle industries. The substrates that are suitable for larval development of the main vector species are still relatively unknown. This study assessed all the substrates present in the immediate surroundings of a Belgian cattle farm and aimed to highlight the main breeding sites of these midge species. A total of 1639 immature Culicoides and 1320 adult specimens belonging to 13 species were found in 15 out of the 43 substrates studied: maize silage residues for C. obsoletus/C. scoticus, old overwintered cattle dung in the meadow for C. chiopterus and C. dewulfi, ground of a flooded meadow, green filamentous algae and underlying substrate, silt from a pond, and ground of hollows caused by the crossing of machines on a dirt track for C. festivipennis, silt from a pond for C. nubeculosus, and ground of a flooded meadow for C. lupicaris. Identification of these micro-habitats and the associations among the species they contain could allow their localization and the development of new strategies of vector control, while preventing the creation of new Culicoides larval micro-habitats. Finally, measures designed to reduce larval populations could improve efficacy of vaccination campaigns against BTV in Europe. [less ▲]

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See detailActivité physique et maladies neuromusculaires
WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2013)

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See detailRECOMMANDATIONS EUROPÉENNES POUR LA PRISE EN CHARGE DU DIABÈTE, DU PRÉ-DIABÈTE ET DES MALADIES CARDIO-VASCULAIRES 2ème partie. Gestion des complications cardiaques, cérébro-vasculaires et artériopathiques périphériques
SCHEEN, André ULg; LANCELLOTTI, Patrizio ULg

in Revue Médicale de Liège (2013), 68(12), 617-624

Summary : Patients with prediabetes (dysglycaemia) or diabetes present accelerated atherosclerosis that predisposes them to multiple cardiovascular complications. We summarize here the joint ... [more ▼]

Summary : Patients with prediabetes (dysglycaemia) or diabetes present accelerated atherosclerosis that predisposes them to multiple cardiovascular complications. We summarize here the joint recommendations recently published by the European Society of Cardiology and the European Society for the Study of Diabetes. The management of main risk factors, aiming to optimize primary or secondary prevention, has been developed in a first article. This second article is focusing on the management of cardiac, cerebrovascular and peripheral arteriopathic complications. The importance of an individualized patient-centered strategy is emphasized, including the management of microangiopathies and, ideally, within a multidisciplinary approach. [less ▲]

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See detailEgg and meat production performances of two varieties of the local Ardennaise poultry breed: silver black and golden black
Moula, Nassim ULg; Michaux, Charles ULg; Philippe, François-Xavier ULg et al

in Animal Genetic Resources = Resources Génétiques Animales = Recursos Genéticos Animales (2013), 53(2), 57-67

The Ardennaise breed is emblematic of the Belgian poultry diversity. We compared two varieties of the breed, the golden black and the silver black. The comparison encompassed: (i) the morphology of adult ... [more ▼]

The Ardennaise breed is emblematic of the Belgian poultry diversity. We compared two varieties of the breed, the golden black and the silver black. The comparison encompassed: (i) the morphology of adult birds, (ii) the growth, carcass characteristics and meat quality of broilers 22 weeks old, (iii) the laying rate during 52 weeks and the egg quality. Significant differences were observed in the size of mature males and females: body weight, diameter and length of the tarsus, size of the comb and wattles. The two varieties did not differ concerning the carcass and meat quality traits. The golden black has a higher laying rate and a higher yolk / albumen ratio, but lays lighter eggs. It could be interesting to complete this study by molecular markers analysis to evaluate the degree of genetic diversity between the two varieties. [less ▲]

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See detailPeptidomic comparison and characterization of the major components of the venom of the giant ant Dinoponera quadriceps collected in four different areas of Brazil.
Cologna, Camila Takeno; Cardoso, Jaqueline Dos Santos; Jourdan, Emmanuel et al

in Journal of Proteomics (2013), 94

Despite the noxious effects inflicted by Dinoponera ant's envenomation, the information about the biological properties and composition of their venom is still very limited. Ants from the genus Dinoponera ... [more ▼]

Despite the noxious effects inflicted by Dinoponera ant's envenomation, the information about the biological properties and composition of their venom is still very limited. Ants from the genus Dinoponera are believed to be the world's largest living ants with a body length of 3cm. Their occurrence is restricted to tropical areas of South America. In this work, we study the venom of the giant Dinoponera quadriceps ant collected in 4 different regions of Brazil. By using a combination of complementary mass spectrometric approaches, we aim at: (i) characterizing the venom composition of these ants; (ii) establishing a comparative analysis of the venom from four geographically different regions in Brazil. This approach demonstrates that ant venom is a copious source of new compounds. Several peptides were identified and selected for "de novo sequencing". Since most of the new peptides showed similarities with antimicrobial peptides (AMPs), antimicrobial assays were performed with the purpose of evaluating their activity. In regard to the comparative study of the four regions, we observed not only major differences in the venom compositions, but also that the venoms collected in closest areas are more similar than the ones collected in distant regions. These observations seem to highlight an adaption of the ant venoms to the local environment. Concerning the biological assays, the peptides called Dq-3162 and Da-3177 showed a wide-ranging antimicrobial activity. The characterization of new AMPs with a broad spectrum of activity and different scaffolds may aid scientists to design new therapeutic agents and understand the mechanisms of those peptides to interact with microbial membranes. The results obtained betoken the biotechnological potential of ant's venom. BIOLOGICAL SIGNIFICANCE: For the first time this manuscript describes an extensive proteomics characterization of the D. quadriceps venom. In addition this study reports the variation in venom composition of primitive ants from 4 geographically different areas of Brazil. The results reveal the presence of ~335 compounds for each venom/area and inter-colony variations were observed. 16 new peptides were characterized and 2 of them were synthesized and biologically assayed. These findings highlight the considerable and still unexplored diversity of ant's venom which could be used as valuable research tools in different areas of knowledge. [less ▲]

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See detailModel Predictive Control of Voltages in Active Distribution Networks
Valverde Mora, Gustavo ULg; Van Cutsem, Thierry ULg

in IEEE Transactions on Smart Grid (2013), 4(4), 2152-2161

This paper presents a centralized control scheme to regulate distribution network voltages in the presence of high penetration of distributed generation. The approach is inspired of Model Predictive ... [more ▼]

This paper presents a centralized control scheme to regulate distribution network voltages in the presence of high penetration of distributed generation. The approach is inspired of Model Predictive Control in order to compensate for modeling inaccuracies and measurement noise. The control actions, calculated from a multi-step optimization, are updated and corrected by real-time measurements. The proposed controller uses a linear model to predict the behavior of the system and the optimization is solved using quadratic programming. The proposed corrective control has been tested in a 11-kV distribution network including 75 nodes and hosting 22 distributed generating units. [less ▲]

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See detailMicrobial, biochemical and sensorial quality assessment of Algerian farmed tilapia (Oreochromis niloticus) stored at 4 and 30°C
Dergal, Nadir; Abi-Ayad, S.M.E.-A.; Degand, Guy ULg et al

in African Journal of Food Science (2013), 7(12), 498-507

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See detailDe l’expérimentation à la modélisation des propriétés hygrothermiques de parois isolées en paille
Louis, Arnaud ULg; Evrard, Arnaud; Courard, Luc ULg et al

in Annales du Bâtiment et des Travaux Publics (2013)

Some results of aPROpaille project are presented. The goal of this project is to improve the knowledge about hygrothermal performances of walls in which thermal insulation is mainly provided by straw ... [more ▼]

Some results of aPROpaille project are presented. The goal of this project is to improve the knowledge about hygrothermal performances of walls in which thermal insulation is mainly provided by straw. Besides an overall characterization of straw properties and two types of earth plaster, a series of tests was performed to determine the hygrothermal properties of these materials: porosity, sorption curve, water vapour diffusion, capillary absorption, total water absorption, specific heat and thermal conductivity. The determination of these parameters required sometimes the implementation of unusual protocols or unreleased materials. Numerical simulations based on the properties defined in the test campaign are also presented. Results clearly point out the influence of the type of plaster and the orientation of fibres into straw bale. [less ▲]

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See detailA Review of the Empirical Research in Management Control, Strategy and Sustainability
Crutzen, Nathalie ULg; Herzig, Christian

in Studies in Managerial and Financial Accounting (2013), 26

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See detailL'efficacité de l'aide en santé en Afrique de l'Ouest: maintenant plus que jamais
Paul, Elisabeth ULg; Eclou, Dieudonné; Sossouhounto, Nadine et al

in Global Health Promotion (2013)

La préoccupation d'améliorer l'efficacité de l'aide au développement dans le secteur de la santé est plus que jamais d’actualité. L'approche sectorielle permet d'obtenir des améliorations importantes à ce ... [more ▼]

La préoccupation d'améliorer l'efficacité de l'aide au développement dans le secteur de la santé est plus que jamais d’actualité. L'approche sectorielle permet d'obtenir des améliorations importantes à ce niveau et connaît un renouveau à travers le Partenariat International pour la Santé et initiatives liées (IHP+). Dans ce commentaire, nous montrons comment l'IHP+ a été mis en œuvre dans trois pays ouest-africains francophones: le Bénin, le Burkina Faso et le Mali. La dynamique existant dans le secteur de la santé dans chacun des pays a influencé la façon dont l'IHP+ s’y est traduit. Au-delà de ces dynamiques différentes, l'IHP+ a permis de renforcer la place des plans et dispositifs nationaux de coordination comme plateforme de suivi-évaluation et de redevabilité du secteur santé. Toutefois, certaines pratiques contraires aux principes de l'efficacité de l'aide perdurent encore, en particulier le manque d'alignement sur les systèmes de gestion nationaux et le manque de prévisibilité de l'aide. [less ▲]

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See detailEffect of non-sperm cells removal with single layer colloidal centrifugation on myeloperoxidase concentration in post-thaw equine semen
Ponthier, Jérôme ULg; Teague, Sheila; Franck, Thierry ULg et al

in Theriogenology (2013), 80(9), 1082-1087

Myeloperoxidase (MPO) is a pro-oxidant enzyme contained in, and released by, neutrophils during degranulation or after lysis. Post-thaw semen contains MPO and its concentration is associated with ... [more ▼]

Myeloperoxidase (MPO) is a pro-oxidant enzyme contained in, and released by, neutrophils during degranulation or after lysis. Post-thaw semen contains MPO and its concentration is associated with decreased sperm motility. Recently, MPO concentration in post-thaw semen was shown to be associated with presence of non-sperm cells. The aim of this study was to describe the effect of centrifugal fractionation of semen prior to cryopreservation on post-thaw concentrations of non-sperm cells and MPO. The experimental design consisted in freezing semen with or without previous centrifugation through two concentrations of single layer colloid media. Non-sperm cells and MPO concentrations were assessed in pellet and upper layer at each step of the procedure and MPO was detected in cells by immunocytochemistry. Single layer colloid centrifugation decreased non-sperm cells and MPO concentrations in post-thaw semen. The MPO concentration was correlated with concentration of non-sperm cells in the upper layer of the supernatant. In post-thaw semen, with or without previous single layer colloid centrifugation, MPO concentration was correlated with concentration of non-sperm cells. Overall, neutrophils were rarely observed and non-sperm cells were mainly epithelial cells or cellular debris, as demonstrated by MPO immunocytochemistry. Following single layer colloid centrifugation, MPO concentration was decreased, and correlations observed in different samples of the experiments revealed an association between concentrations of MPO and non-sperm cells. At all steps of the semen processing and cryopreservation, MPO immunostaining was clearly identified only on non-sperm cells. Our results demonstrate that non-sperm cells present in fresh semen release MPO during freezing. [less ▲]

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See detailDosimétrie vocale chez des enseignantes des niveaux maternel et primaire
Remacle, Angélique ULg; Morsomme, Dominique ULg; FINCK, Camille ULg

in Cahiers de l'ASELF (2013), 10(4), 14-29

Objectifs - Cette étude quantifie l’usage vocal professionnel et extra-professionnel chez des enseignantes en différenciant deux niveaux scolaires : le maternel et le primaire. L’objectif est d’identifier ... [more ▼]

Objectifs - Cette étude quantifie l’usage vocal professionnel et extra-professionnel chez des enseignantes en différenciant deux niveaux scolaires : le maternel et le primaire. L’objectif est d’identifier le contexte (professionnel versus extra- professionnel) ainsi que le niveau scolaire (maternel versus primaire) requérant la charge vocale la plus importante. Méthodologie - Le comportement vocal de 21 enseignantes du maternel et de 20 enseignantes du primaire a été accumulé à l’aide d’un dosimètre pendant une semaine de travail (5 jours). Les paramètres analysés sont les suivants : l’intensité vocale, la fréquence fondamentale, la durée de phonation, le nombre de vibrations et la distance parcourue par les plis vocaux. Résultats - Comme attendu, le contexte professionnel est associé à des valeurs significativement plus élevées que le contexte extra-professionnel pour tous les paramètres mesurés. Par ailleurs, la comparaison entre les deux groupes montre des valeurs significativement plus élevées chez les enseignantes du maternel pour le nombre de vibrations et la distance parcourue par les plis vocaux. Conclusions - Le risque de développer des pathologies liées à la charge vocale est principalement associé à l’usage vocal professionnel des enseignantes, et il semble davantage présent chez les institutrices du niveau maternel que chez celles du primaire. [less ▲]

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See detailTrophic Relationships and Habitat Preferences of Delphinids from the Southeastern Brazilian Coast Determined by Carbon and Nitrogen Stable Isotope Composition
Bisi, Tatiana; Dorneles, Paulo; Lailson-Brito, José et al

in PLoS ONE (2013), 8(12),

To investigate the foraging habitats of delphinids in southeastern Brazil, we analyzed stable carbon (δ13C) and nitrogen (δ15N) isotopes in muscle samples of the following 10 delphinid species: Sotalia ... [more ▼]

To investigate the foraging habitats of delphinids in southeastern Brazil, we analyzed stable carbon (δ13C) and nitrogen (δ15N) isotopes in muscle samples of the following 10 delphinid species: Sotalia guianensis, Stenella frontalis, Tursiops truncatus, Steno bredanensis, Pseudorca crassidens, Delphinus sp., Lagenodelphis hosei, Stenella attenuata, Stenella longirostris and Grampus griseus. We also compared the δ13C and δ15N values among four populations of S. guianensis. Variation in carbon isotope results from coast to ocean indicated that there was a significant decrease in δ13C values from estuarine dolphins to oceanic species. S. guianensis from Guanabara Bay had the highest mean δ13C value, while oceanic species showed significantly lower δ13C values. The highest δ15N values were observed for P. crassidens and T. truncatus, suggesting that these species occupy the highest trophic position among the delphinids studied here. The oceanic species S. attenuata, G. griseus and L. hosei had the lowest δ15N values. Stable isotope analysis showed that the three populations of S. guianensis in coastal bays had different δ13C values, but similar δ15N results. Guiana dolphins from Sepetiba and Ilha Grande bays had different foraging habitat, with specimens from Ilha Grande showing more negative δ13C values. This study provides further information on the feeding ecology of delphinids occurring in southeastern Brazil, with evidence of distinctive foraging habitats and the occupation of different ecological niches by these species in the study area. [less ▲]

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See detailDiabète et nutrition artificielle : principes de prise en charge
Quilliot, Didier; Malgras, Aurélie; PAQUOT, Nicolas ULg et al

in Nutrition Clinique et Metabolisme (2013), 27(4), 230-235

At home as in the hospital, the diabetic patients are at high risk of malnutrition. In patients with hyperglycemia in artificial nutrition, the primary objective is to to cover their protein needs and ... [more ▼]

At home as in the hospital, the diabetic patients are at high risk of malnutrition. In patients with hyperglycemia in artificial nutrition, the primary objective is to to cover their protein needs and their caloric needs and to optimize accordingly the antidiabetic treatment. Insulin therapy is the treatment of choice. The use of low glycaemic index is probably better, especially for oral supplementation. An equivalent parenteral carbohydrate intake has a hyperglycaemic effect more important than with the oral or enteral way. The management of hyperglycemia in artificial nutrition requires defining glycemic goals, tailored to the patient, to the type and the sequences of artificial nutrition, establishing patterns of insulin therapy and providing accurate adaptation rules. Above the basal requirement, insulin therapy sufficient to meet caloric exposure must be prescribed appropriate in timing with the artificial nutrition. The use of sliding scale as monotherapy is ineffective. This management requires forming the nurse team. The acute phase has passed, the disease stabilized, it is sometimes possible to introduce oral antidiabetic drugs and stop insulin. In this case, we apply the same prescription rules to these drugs as for the patient fed orally. [less ▲]

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See detailFamily Members of Patients with Abdominal Aortic Aneurysms are at Increased Risk for Aneurysms: Analysis of 618 Probands and their Families from the Liege AAA Family Study.
SAKALIHASAN, Natzi ULg; Defraigne, Jean-Olivier ULg; Kerstenne, Marie-Ange et al

in Annals of vascular surgery (2013), doi: 10.1016/j.avsg.2013.11.005.

BACKGROUND: The objectives were to answer the following questions using a well-characterized population in Liege, Belgium: 1) what percentage of abdominal aortic aneurysm (AAA) patients have a positive ... [more ▼]

BACKGROUND: The objectives were to answer the following questions using a well-characterized population in Liege, Belgium: 1) what percentage of abdominal aortic aneurysm (AAA) patients have a positive family history for AAA, 2) what is the prevalence of AAAs among relatives of AAA patients; and 3) do familial and sporadic AAA cases differ in clinical characteristics. METHODS AND RESULTS: Unrelated AAA patients diagnosed at the Cardiovascular Surgery Department, University Hospital of Liege, Belgium, between 1999 and 2012 were invited to the study. A detailed family history was obtained in interviews and recorded using Progeny software. In the initial interview 62 (10%) of the 618 AAA patients reported a positive family history for AAA. We divided the 618 patients into two study groups: Group I: 296 AAA patients (268; 91% males) were followed up with computerized tomography combined with positron emission tomography, and Group II: 322 AAA patients (295; 92% males) whose families were invited to ultrasonography screening. Ultrasonography screening identified 24 new AAAs among 186 relatives (>/= 50 years) of 144 families yielding a prevalence of 13%. The highest prevalence (25%) was found among brothers. By combining the number of AAAs found by ultrasonography screening with those diagnosed previously the observed lifetime prevalence of AAA was estimated to be 32% in brothers. The familial AAA cases were more likely to have a ruptured AAA than the sporadic cases (8% vs. 2.4%; P<0.0001). CONCLUSIONS: The findings confirm previously found high prevalence of AAA among brothers, support genetic contribution to AAA pathogenesis and provide rationale for targeted screening of relatives of AAA patients. [less ▲]

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See detail"La perte des avantages matrimoniaux pour cause d'indignité"
Moreau, Pierre ULg

in Revue du Notariat Belge (2013), (3080), 810-832

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See detailDéploiement de la solution discovery Primo à l'Université de Liège
Renaville, François ULg; Richelle, Laurence ULg

in Cahiers de la Documentation = Bladen voor Documentatie (2013), (4), 41-53

En quelques années, les Bibliothèques de l'Université de Liège (ULg) ont procédé à d'importants changements dans les systèmes documentaires informatisés qu'elles exploitent (SIGB, OPAC, résolveur de liens ... [more ▼]

En quelques années, les Bibliothèques de l'Université de Liège (ULg) ont procédé à d'importants changements dans les systèmes documentaires informatisés qu'elles exploitent (SIGB, OPAC, résolveur de liens, plate-forme PIB…). Cet article retrace le passage, en 2013, d’un OPAC traditionnel à une "solution discovery". L'équipe de projet propose une analyse des étapes qui ont précédé la mise en œuvre de la solution Primo, dans ses différents aspects historique, technique et humain. La campagne de communication en interne, au moyen principalement de séances de formation, est également abordée. [less ▲]

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See detailExpanding the CHARA/FLUOR hot disk survey
Mennesson, B.; Scott, N.; Ten Brummelaar, T. et al

in Journal of Astronomical Instrumentation (2013), 2(2), 1340010

Little is presently known about the hot (>300 K) dust component of debris disks surrounding main sequence stars, similar to the zodiacal dust cloud found in the inner solar system.While extensive surveys ... [more ▼]

Little is presently known about the hot (>300 K) dust component of debris disks surrounding main sequence stars, similar to the zodiacal dust cloud found in the inner solar system.While extensive surveys have been carried out from space, the majority of detections have surprisingly come from the ground, where near infrared interferometric observations have recently revealed small (∼1%) resolved excesses around a dozen nearby main sequence stars. Most of these results have come from the CHARA array “FLUOR” instrument (Mt. Wilson, CA), which has demonstrated the best sensitivity worldwide so far for this type of studies, and has carried out an initial survey of ∼40 stars. In order to further understand the origin of this “hot dust phenomenon”, we will extend this initial survey to a larger number of stars and lower excess detection limits, i.e. higher visibility accuracy providing higher contrast measurements. To this end, two major instrumental developments are underway at CHARA. The first one aims at improving FLUOR’s sensitivity to a median K-band magnitude limit of 5 (making 200 targets available). The second development is based on a method that we recently developed for accurate (better than 0.1%) null depth measurements of stars, and that can be extended to regular interferometric visibility measurements. [less ▲]

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