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See detailIs conspecific substrate marking a long-term external memory of previously colonized overwintering sites in Harmonia axyridis?
Durieux, Delphine ULg; Fassotte, Bérénice ULg; Vanderplanck, Maryse et al

in Journal of Applied Entomology (2014), 138(5), 338-345

The multicoloured Asian ladybeetle, Harmonia axyridis (Pallas), aggregates inside dwellings during winters to survive the cold. This beetle uses chemical cues coming from congeners to select an ... [more ▼]

The multicoloured Asian ladybeetle, Harmonia axyridis (Pallas), aggregates inside dwellings during winters to survive the cold. This beetle uses chemical cues coming from congeners to select an overwintering site. Recent research has shown that they preferentially gather at places where conspecifics previously laid a substrate marking made up of saturated and unsaturated hydrocarbons. Some authors have reported that H. axyridis colonizes the same overwintering sites from 1 year to another. Herein, the hypothesis that this substrate marking is used by H. axyridis to settle in the same aggregation sites from one winter to another was tested. To this aim, the temporal modification in the chemical profile of the hydrocarbon marking was studied by performing chromatographic analyses. After 1 year, the overall profile was modified qualitatively and quantitatively: the unsaturated hydrocarbons were no longer detected while some saturated hydrocarbons were still present in large quantities. In a behavioural assay conducted in the laboratory, the 12-month-old marking did not induce the aggregation of H. axyridis. This result indicates that the chemical markings left by conspecifics during a previous aggregation period in an overwintering site are not sufficient to induce the gathering of the newly arriving individuals. [less ▲]

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See detailFalsos positivos de C5-carnitina elevada en cribado neonatal: A que son debidos?
Yahyaoui, Raquel; Rueda; Dayaldasani, Anita et al

in Medicina Clinica (2014)

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See detailEffect of concentration in Ge-Te liquids: A combined density functional and neutron scattering study
Micoulaut, Matthieu; Coulet, M.V.; Piarristeguy, A. et al

in Physical Review. B : Solid State (2014), 89(17), 174205

The structural properties of three compositions of Ge-Te liquids (Ge10Te90, Ge15Te85, Ge20Te80) are studied from a combination of density functional based molecular dynamics simulations and neutron ... [more ▼]

The structural properties of three compositions of Ge-Te liquids (Ge10Te90, Ge15Te85, Ge20Te80) are studied from a combination of density functional based molecular dynamics simulations and neutron scattering experiments. We investigate structural properties including structure factors, pair distribution functions, angular distributions, coordination numbers, neighbor distributions and compare our results with experimental findings. Most noticeable is the good agreement found in the reproduction of the structure in real and reciprocal space, resulting from the incorporation of dispersion forces in the simulation. This leads to Ge and Te coordination numbers which are lower than in previous studies and which can now be followed with temperature, while also strongly depending on the chosen cutoff distance. Results show a gradual conversion of higher coordinated species (TeIV, GeV) into lower coordinated ones at lower temperature, while leaving anticipated coordinations from the octet rule (TeII and GeIV) nearly unchanged. Structural correlations are characterized as a function of temperature and composition. The vibrational density of states is also measured from inelastic neutron scattering for different compositions and temperatures, and compared to the simulated counterpart which exhibits a reasonable agreement at low frequency. [less ▲]

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See detailGenome-Wide Association Interaction Analysis for Alzheimer’s Disease
Gusareva, Elena ULg; Carrasquillo, Minerva M.; Bellenguez, Céline et al

in Neurobiology of Aging (2014)

We propose a minimal protocol for exhaustive genome-wide association interaction analysis that involves screening for epistasis over large-scale genomic data combining strengths of different methods and ... [more ▼]

We propose a minimal protocol for exhaustive genome-wide association interaction analysis that involves screening for epistasis over large-scale genomic data combining strengths of different methods and statistical tools. The different steps of this protocol are illustrated on a real-life data application for Alzheimer's disease (AD) (2259 patients and 6017 controls from France). Particularly, in the exhaustive genome-wide epistasis screening we identified AD-associated interacting SNPs-pair from chromosome 6q11.1 (rs6455128, the KHDRBS2 gene) and 13q12.11 (rs7989332, the CRYL1 gene) (p = 0.006, corrected for multiple testing). A replication analysis in the independent AD cohort from Germany (555 patients and 824 controls) confirmed the discovered epistasis signal (p = 0.036). This signal was also supported by a meta-analysis approach in 5 independent AD cohorts that was applied in the context of epistasis for the first time. Transcriptome analysis revealed negative correlation between expression levels of KHDRBS2 and CRYL1 in both the temporal cortex (β = -0.19, p = 0.0006) and cerebellum (β = -0.23, p < 0.0001) brain regions. This is the first time a replicable epistasis associated with AD was identified using a hypothesis free screening approach. [less ▲]

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See detailNear-death experiences in non-life-threatening events and coma of different etiologies.
Charland-Verville, Vanessa ULg; Jourdan, Jean-Pierre; Thonnard, Marie ULg et al

in Frontiers in human neuroscience (2014), 8(203),

BACKGROUND: Near death experiences (NDEs) are increasingly being reported as a clearly identifiable physiological and psychological reality of clinical significance. However, the definition and causes of ... [more ▼]

BACKGROUND: Near death experiences (NDEs) are increasingly being reported as a clearly identifiable physiological and psychological reality of clinical significance. However, the definition and causes of the phenomenon as well as the identification of NDE experiencers is still a matter of debate. To date, the most widely used standardized tool to identify and characterize NDEs in research is the Greyson NDE scale. Using this scale, retrospective and prospective studies have been trying to estimate their incidence in various populations but few studies have attempted to associate the experiences' intensity and content to etiology. METHODS: This retrospective investigation assessed the intensity and the most frequently recounted features of self-reported NDEs after a non-life-threatening event (i.e., "NDE-like" experience) or after a pathological coma (i.e., "real NDE") and according to the etiology of the acute brain insult. We also compared our retrospectively acquired data in anoxic coma with historical data from the published literature on prospective post-anoxic studies using the Greyson NDE scale. RESULTS: From our 190 reports who met the criteria for NDE (i.e., Greyson NDE scale total score >7/32), intensity (i.e., Greyson NDE scale total score) and content (i.e., Greyson NDE scale features) did not differ between "NDE-like" (n = 50) and "real NDE" (n = 140) groups, nor within the "real NDE" group depending on the cause of coma (anoxic/traumatic/other). The most frequently reported feature was peacefulness (89-93%). Only 2 patients (1%) recounted a negative experience. The overall NDE core features' frequencies were higher in our retrospective anoxic cohort when compared to historical published prospective data. CONCLUSIONS: It appears that "real NDEs" after coma of different etiologies are similar to "NDE-like" experiences occurring after non-life threatening events. Subjects reporting NDEs retrospectively tend to have experienced a different content compared to the prospective experiencers. [less ▲]

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See detailProbabilistic Assessment of the Lifetime of Low-Earth-Orbit Spacecraft: Uncertainty Characterization
Dell'Elce, Lamberto ULg; Arnst, Maarten ULg; Kerschen, Gaëtan ULg

in Journal of Guidance Control & Dynamics (2014)

Orbital lifetime estimation is a problem of great timeliness and importance in astrodynamics. In view of the stochastic nature of the thermosphere and of the complexity of drag modeling, any deterministic ... [more ▼]

Orbital lifetime estimation is a problem of great timeliness and importance in astrodynamics. In view of the stochastic nature of the thermosphere and of the complexity of drag modeling, any deterministic assessment of orbital lifetime is likely to be bound to failure. This is why the present paper performs uncertainty quantification of satellite orbital lifetime estimation. Specifically, this paper focuses on the probabilistic characterization of the dominant sources of uncertainty inherent to low-altitude satellites. Uncertainties in the initial state of the satellite and in the atmospheric drag force, as well as uncertainties introduced by modeling limitations associated with atmospheric density models, are considered. Mathematical statistics methods, in conjunction with mechanical modeling considerations, are used to infer the probabilistic characterization of these uncertainties from experimental data and atmospheric density models. This characterization step facilitates the application of uncertainty propagation and sensitivity analysis methods, which in turn allows gaining insight into the impact that these uncertainties have on the orbital lifetime. The proposed developments are illustrated using one CubeSat of the QB50 constellation. [less ▲]

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See detailTemperature regimes and aphid density interactions differentially influence VOC emissions in Arabidopsis
Hien, Truong Thi Dieu ULg; Delory, Benjamin ULg; Vanderplanck, Maryse et al

in Arthropod-Plant Interactions (2014), 8(4), 317-327

The effects of volatile emissions from plants exposed to individual abiotic and biotic stresses are well documented. However, the influence of multiple stresses on plant photosynthesis and defense ... [more ▼]

The effects of volatile emissions from plants exposed to individual abiotic and biotic stresses are well documented. However, the influence of multiple stresses on plant photosynthesis and defense responses, resulting in a variety of volatile profiles has received little attention. In this study, we investigated how temperature regimes in the presence and absence of the sucking insect Myzus persicae affected volatile organic compound emissions in Arabidopsis over three time periods (0-24 h, 24-48 h, and 48-72 h). Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry was used to evaluate Arabidopsis volatile organic compounds. The results showed that under laboratory conditions, eight volatile classes [alcohols (mainly 2-ethyl-hexan-1-ol), ketone (6-methyl hept-5-en-2-one), esters (mainly (Z)-3-hexenyl acetate), aldehydes (mainly phenylacetaldehyde), isothiocyanates (mainly 4-methylpentyl isothiocyanate), terpenes (mainly (E,E)-α-farnesene), nitrile (5-(methylthio) pentanenitrile), and sulfide (dimethyl trisulfide)] were observed on plants exposed to stress combinations, whereas emissions of six volatile classes were observed during temperature stress treatments alone (with the exception of nitriles and sulfides). Aphid density at high temperature combinations resulted in significantly higher isothiocyanate, ester, nitrile and sulfide proportions. The results of the present study provide an insight into the effects of temperature - aphid interactions on plant volatile emissions. [less ▲]

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See detailInteractive comment on “Improved routines to model the ocean carbonate system: mocsy 1.0” by J. C. Orr and J.-M Epitalon
Munhoven, Guy ULg

in Geoscientific Model Development Discussions [=GMDD] (2014), 7

The manuscript "Improved routines to model the ocean carbonate system: mocsy 1.0" by J. C. Orr and J.-M Epitalon is reviewed and related issues and ideas are discussed.

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See detailAn independent SSVEP-based brain-computer interface in locked-in-syndrome
Lesenfants, Damien ULg; Habbal, Dina; Lugo et al

in Journal of Neural Engineering (2014)

OBJECTIVE: Steady-state visually evoked potential (SSVEP)-based brain-computer interfaces (BCIs) allow healthy subjects to communicate. However, their dependence on gaze control prevents their use with ... [more ▼]

OBJECTIVE: Steady-state visually evoked potential (SSVEP)-based brain-computer interfaces (BCIs) allow healthy subjects to communicate. However, their dependence on gaze control prevents their use with severely disabled patients. Gaze-independent SSVEP-BCIs have been designed but have shown a drop in accuracy and have not been tested in brain-injured patients. In the present paper, we propose a novel independent SSVEP-BCI based on covert attention with an improved classification rate. We study the influence of feature extraction algorithms and the number of harmonics. Finally, we test online communication on healthy volunteers and patients with locked-in syndrome (LIS). APPROACH: Twenty-four healthy subjects and six LIS patients participated in this study. An independent covert two-class SSVEP paradigm was used with a newly developed portable light emitting diode-based 'interlaced squares' stimulation pattern. MAIN RESULTS: Mean offline and online accuracies on healthy subjects were respectively 85 ± 2% and 74 ± 13%, with eight out of twelve subjects succeeding to communicate efficiently with 80 ± 9% accuracy. Two out of six LIS patients reached an offline accuracy above the chance level, illustrating a response to a command. One out of four LIS patients could communicate online. SIGNIFICANCE: We have demonstrated the feasibility of online communication with a covert SSVEP paradigm that is truly independent of all neuromuscular functions. The potential clinical use of the presented BCI system as a diagnostic (i.e., detecting command-following) and communication tool for severely brain-injured patients will need to be further explored. [less ▲]

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See detailMeandering jets in shallow rectangular reservoirs: POD analysis and identification of coherent structures
Peltier, Yann ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Experiments in Fluids (2014), 55

The effect of the shallowness on meandering jets in a shallow rectangular reservoir is investigated. Four meandering flows were investigated in an experimental shallow rectangular reservoir. Their ... [more ▼]

The effect of the shallowness on meandering jets in a shallow rectangular reservoir is investigated. Four meandering flows were investigated in an experimental shallow rectangular reservoir. Their boundary conditions were chosen to cover a large range of friction numbers (defined with the sudden expansion width). Due to the unsteady characteristics of the flows, a Proper Orthogonal Decomposition of the fluctu-ating part of the surface velocity fields measured using LSPIV was used for discriminating the flow struc-tures responsible for the meandering of the jet. Less than 1 % of the calculated POD modes significantly contribute to the meandering of the jet and two types of instability are in competition in such a flow con-figuration. The sinuous mode is the dominant mode in the flow and it induces the meandering of the flow, while the varicose mode is a source of local mixing and weakly participates to the flow. The fluctuating velocity fields were then reconstructed using the POD modes corresponding to 80% of the total mean fluctuating kinetic energy and the coherent structures were identified using the residual vorticity, their centres being localised using a topology algorithm. The trajectories of the structures centres emphasize that at high friction number the coherent structures are small and laterally paired in the near, middle and far fields of the jet, while with decreasing friction number the structures merge into large horizontal vortices in the far-field of the jet, their trajectories showing more variability in space and time. The analysis of the stability regime finally reveals that the sinuous mode is convectively unstable and may become absolutely unstable at the end of the reservoir when the friction number is small. [less ▲]

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See detailFrom propaganda to commemoration: reworking the national narrative.
Hamers, Jérémy ULg; Van Cauwenberge, Geneviève ULg

in Rethinking History (2014), 18(3), 423-437

In Belgium, memories of the World War I have contributed to the production and the perpetuation of a fractured national narrative. While the official narration emphasizes the unity of the Belgian state ... [more ▼]

In Belgium, memories of the World War I have contributed to the production and the perpetuation of a fractured national narrative. While the official narration emphasizes the unity of the Belgian state and glorifies the heroism of Belgian soldiers acting as a unified force against the German invader, a counter-narrative presents the Flemish soldiers as victims who were used as cannon fodder by the French-speaking commanding elite. In the immediate postwar period, newsreels largely reinforced the image of a national unity during the Great War. Ten years later, however, cinema took an active part in the production of a counter-memory. Met onze jogens aan den IJzer/With Our Troops on the Yser (Clemens De Landtsheer, 1928), a Flemish film, is a key work in this regard. This article first examines the narratives and formal strategies the film resorts to in order to forcefully deconstruct the patriotic narrative and to forge a ‘Flamingant,’ Flemish activist collective memory. It subsequently analyzes more recent Frenchspeaking documentary film projects aiming to commemorate the memory of the Great War. Lacking any overt problematization of their relationship to the Flemish separatist narrative, the documentaries are still shaped by it. Indeed, they either attempt to overcome it by reinforcing Belgium’s sense of national identity or to counterbalance it by putting forward a regional narrative that specifically revives the French-speaking Belgians’ memory of the War. [less ▲]

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See detailPeripheral Synergism Between Tramadol and Ibuprofen in the Formalin Test
Chavarria Bolanos, Daniel ULg; Perez-Urizar, Jose; Grandfils, Christian ULg et al

in Drug Development Research (2014), 75(4), 224-230

Analgesics with different mechanisms of action can be combined in order to obtain Pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical ... [more ▼]

Analgesics with different mechanisms of action can be combined in order to obtain Pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical dual analgesic such as tramadol (TMD) and a nonsteroidal anti-inflammatory drug such as ibuprofen (IBU) are good candidates to be evaluated when combined and applied peripherally. The present study was conducted to evaluate possible local synergism between TMD and IBU when combined peripherally using the formalin test in rats. The effects of the individual analgesics and their combinations were evaluated simultaneously using a 5% formalin dilution. Dose–effect curves were determined for TMD (50–400 μg/paw) and IBU (1–100 μg/paw). Experimental effective doses were evaluated and isobolographic analyses were constructed to evaluate TMD-IBU combination synergism. Both drugs produced a dose-dependent analgesic effect when applied separately. Isobolographic analysis showed synergism during phase 1 (0–10 min) and phase 2 (15–60 min) when compared with theoretical doses (P < 0.05), with interaction indexes of 0.06 and 0.09, respectively. The present information supports the peripheral analgesic effect of TMD and IBU, especially when combined at appropriate doses. [less ▲]

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See detailPrévention quaternaire : agir est-il toujours justifié en médecine de famille ?
Widmer, Daniel; Herzig, Lilly; Jamoulle, Marc ULg

in Revue Médicale Suisse (2014), 10(430), 1052-6

La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la ... [more ▼]

La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la prévention primaire que du diagnostic précoce, ou sur les risques de la création de nouvelles entités pathologiques et d’une médecine maximaliste. Le médecin de famille favorise la prévention quaternaire en se centrant sur les priorités du patient et sur les ressources locales d’un système de soins efficace. [less ▲]

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See detailLinear amphiphilic diblock copolymers of lactide and 2-dimethylaminoethyl methacrylate using bifunctional-initiator and one-pot approaches
Kryuchkov, Maksym A.; Detrembleur, Christophe ULg; Bazuin, Géraldine

in Polymer (2014), 55(10), 2316-2324

Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring ... [more ▼]

Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring-opening polymerization (ROP) of LLA using the bifunctional initiator, 2′-hydroxyethyl 2-bromoisobutyrate. NMR showed that the resulting PLA block was racemic and a quaternization/precipitation technique showed that there were significant amounts of racemic PLA homopolymer. In addition, simultaneous ATRP of DMAEMA and ROP of l-lactide by tin octoate were conducted at varied temperatures, indicating 90 °C as a suitable compromise temperature; this one-pot process also led to racemization and P(L)LA homopolymer. The racemization was attributed to reversible deprotonation of LLA by the N(CH3)2 moiety of (P)DMAEMA and the PLA homopolymer impurity was related to in situ formation of lactoyl lactate (LA–LA) due to nucleophilic ring opening of lactide by the amino moieties of (P)DMAEMA. The methods presented can be useful for the preparation of PDMAEMA–b–PLA/PLA composites in a two-step process or in a single step, one-pot process. [less ▲]

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See detailSupercritical CO2 and polycarbonate based nanocomposites: A critical issue for foaming
Monnereau, Laure; Urbanczyk, Laetitia; Thomassin, Jean-Michel ULg et al

in Polymer (2014), 55(10), 2422-2431

Supercritical carbon dioxide readily induced foaming of various polymers. In that context, supercritical CO2 was applied to carbon nanotubes based polycarbonate nanocomposites to ensure their foaming ... [more ▼]

Supercritical carbon dioxide readily induced foaming of various polymers. In that context, supercritical CO2 was applied to carbon nanotubes based polycarbonate nanocomposites to ensure their foaming. Surprisingly, efficient foaming only occurs when low pressure is applied while at high pressure, no expansion of the samples was observed. This is related to the ability of supercritical carbon dioxide to induce crystallization of amorphous polycarbonate. Moreover, this behaviour is amplified by the presence of carbon nanotubes that act as nucleating agents for crystals birth. The thermal behaviour of the composites was analysed by DSC and DMA and was related to the foaming observations. The uniformity of the cellular structure was analysed by scanning electron microscopy (SEM). By saturating the polycarbonate nanocomposites reinforced with 1 wt% of MWNTs at 100 bar and 100 °C during 16 h, microcellular foams were generated, with a density of 0.62, a cell size ranging from 0.6 to 4 μm, and a cellular density of 4.1 × 1011 cells cm−3. The high ability of these polymeric foams to absorb electromagnetic radiation was demonstrated at low MWNT content as the result of the high affinity of the polycarbonate matrix for MWNTs, and therefore to the good MWNTs dispersion. [less ▲]

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See detailThe Role of Anthropic, Ecological, and Social Factors in Sleeping Site Choice by Long‐Tailed Macaques (Macaca fascicularis)
Brotcorne, Fany ULg; Maslarov, Cindy; Wandia, I. Nengah et al

in American Journal of Primatology (2014)

When choosing their sleeping sites, primates make adaptive trade‐offs between various biotic and abiotic constraints. In human‐modified environments, anthropic factors may play a role. We assessed the ... [more ▼]

When choosing their sleeping sites, primates make adaptive trade‐offs between various biotic and abiotic constraints. In human‐modified environments, anthropic factors may play a role. We assessed the influence of ecological (predation), social (intergroup competition), and anthropic (proximity to human settlements) factors in sleeping site choice by long‐tailed macaques (Macaca fascicularis) occupying a habitat at the interface of natural forests and human‐modified zones in Bali Barat National Park, Indonesia. Over the course of 56 nights, we collected data relating to physical features of sleeping trees, patterns of the use of sleeping sites within the home range, pre‐sleep behavior, diurnal ranging patterns and availability of natural and human food. Overall, the macaques used 17 sleeping sites with 37 sleeping trees. When the monkeys slept in forest zones, they selected sleeping trees that had larger trunks but were not significantly taller than surrounding trees. Though the macaques rarely re‐used sleeping sites on consecutive nights, they frequently re‐used four sites over the study period. The group favored sleeping within the core area of its home range, despite the occurrence of frequent agonistic intergroup encounters there. Macaques preferentially selected sleeping trees located within or near human‐modified zones, especially when human food was abundant and natural food was scarce. These results partially support the hypothesis that long‐tailed macaques choose their sleeping sites to avoid predation; proximity to human settlements appears to be the primary factor influencing sleeping site choice in this primate species. Our results reflect the strong influence that anthropic factors have on primates, which subsist in increasingly human‐dominated landscapes. [less ▲]

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See detailPassive temperature tomography experiments to characterize transmissivity and connectivity of preferential flow paths in fractured media
Klepikova, Maria ULg

in Journal of Hydrology (2014)

The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive ... [more ▼]

The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive tracer to characterize fracture connectivity and hydraulic properties. In particular, we propose a new temperature tomography field method in which borehole temperature profiles are measured under different pumping conditions by changing successively the pumping and observation boreholes. To interpret these temperature-depth profiles, we propose a three step inversion-based framework. We consider first an inverse model that allows for automatic permeable fracture detection from borehole temperature profiles under pumping conditions. Then we apply a borehole-scale flow and temperature model to produce flowmeter profiles by inversion of temperature profiles. This second step uses inversion to characterize the relationship between temperature variations with depth and borehole flow velocities (Klepikova et al., 2011). The third inverse step, which exploits cross-borehole flowmeter tests, is aimed at inferring inter-borehole fracture connectivity and transmissivities. This multi-step inverse framework provides a means of including temperature profiles to image fracture hydraulic properties and connectivity. We test the proposed approach with field data obtained from the Ploemeur (N.W. France) fractured rock aquifer, where the full temperature tomography experiment was carried out between three 100 m depth boreholes 10 m apart. We identified several transmissive fractures and their connectivity which correspond to known fractures and corroborate well with independent information, including available borehole flowmeter tests and geophysical data. Hence, although indirect, temperature tomography appears to be a promising approach for characterizing connectivity patterns and transmissivities of the main flow paths in fractured rock. [less ▲]

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See detailPassive temperature tomography experiments to characterize transmissivity and connectivity of preferential flow paths in fractured media
Klepikova, Maria ULg

in Journal of Hydrology (2014)

The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive ... [more ▼]

The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive tracer to characterize fracture connectivity and hydraulic properties. In particular, we propose a new temperature tomography field method in which borehole temperature profiles are measured under different pumping conditions by changing successively the pumping and observation boreholes. To interpret these temperature-depth profiles, we propose a three step inversion-based framework. We consider first an inverse model that allows for automatic permeable fracture detection from borehole temperature profiles under pumping conditions. Then we apply a borehole-scale flow and temperature model to produce flowmeter profiles by inversion of temperature profiles. This second step uses inversion to characterize the relationship between temperature variations with depth and borehole flow velocities (Klepikova et al., 2011). The third inverse step, which exploits cross-borehole flowmeter tests, is aimed at inferring inter-borehole fracture connectivity and transmissivities. This multi-step inverse framework provides a means of including temperature profiles to image fracture hydraulic properties and connectivity. We test the proposed approach with field data obtained from the Ploemeur (N.W. France) fractured rock aquifer, where the full temperature tomography experiment was carried out between three 100 m depth boreholes 10 m apart. We identified several transmissive fractures and their connectivity which correspond to known fractures and corroborate well with independent information, including available borehole flowmeter tests and geophysical data. Hence, although indirect, temperature tomography appears to be a promising approach for characterizing connectivity patterns and transmissivities of the main flow paths in fractured rock. [less ▲]

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See detailEnzymatic process for the fractionation of baker’s yeast cell wall (Saccharomyces cerevisiae)
Borchani, Chema; Fonteyn, Fabienne; Jamin, Guilhem et al

in Food Chemistry (2014), 163

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See detailUsing the Multiple SEA Method to Synthesize Pt/Carbon Xerogel Electrocatalysts for PEMFC Applications
Zubiaur, Anthony ULg; Chatenet, Marian; Maillard, Frédéric et al

in Fuel Cells - From Fundamentals to Systems (2014), 14(3), 343-349

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See detailEffect of the RE (RE = Eu, Er) doping on the structural and textural properties of mesoporous TiO2 thin films obtained by evaporation induced self-assembly method
Borlaf, Mario; Caes, Sébastien ULg; Dewalque, Jennifer ULg et al

in Thin Solid Films (2014), 558

Polymeric sol–gel route has been used for the preparation of TiO2 and RE2O3–TiO2 (RE = Eu, Er) mesoporous thin films by evaporation induced self-assembly method using Si (100) as a substrate. The ... [more ▼]

Polymeric sol–gel route has been used for the preparation of TiO2 and RE2O3–TiO2 (RE = Eu, Er) mesoporous thin films by evaporation induced self-assembly method using Si (100) as a substrate. The influence of the relative humidity (RH) on the preparation of the film has been studied being necessary to work under 40% RH in order to obtain homogeneous and transparent thin films. The films were annealed at different temperatures until 900 °C/1 h and the anatase crystallization and its crystal size evolution were followed by low angle X-ray diffraction. Neither the anatase–rutile transition nor the formation of other compounds was observed in the studied temperature range. Ellipsoporosimetry studies demonstrated that the thickness of the thin films did not change after calcination at 500 °C, the porosity was constant until 700 °C, the pore size increased and the specific surface area decreased with temperature. Moreover, the effect of the doping with Er3 + and Eu3 + was studied and a clear inhibition of the crystal growth and the sintering process was detected (by transmission electron and atomic force microscopy) when the doped films are compared with the undoped ones. Finally, Eu3 + and Er3 + f–f transitions were detected by PL measurements. [less ▲]

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See detailMicrolensing of the broad-line region in the quadruply imaged quasar HE0435-1223
Braibant, Lorraine ULg; Hutsemekers, Damien ULg; Sluse, Dominique ULg et al

in Astronomy and Astrophysics (2014), 565

Using infrared spectra of the z = 1.693 quadruply lensed quasar HE0435-1223 acquired in 2009 with the spectrograph SINFONI at the ESO Very Large Telescope, we have detected a clear microlensing effect in ... [more ▼]

Using infrared spectra of the z = 1.693 quadruply lensed quasar HE0435-1223 acquired in 2009 with the spectrograph SINFONI at the ESO Very Large Telescope, we have detected a clear microlensing effect in images A and D. While microlensing affects the blue and red wings of the Hα line profile in image D very differently, it de-magnifies the line core in image A. The combination of these different effects sets constraints on the line-emitting region; these constraints suggest that a rotating ring is at the origin of the Hα line. Visible spectra obtained in 2004 and 2012 indicate that the MgII line profile is microlensed in the same way as the Hα line. Our results therefore favour flattened geometries for the low-ionization line-emitting region, for example, a Keplerian disk. Biconical models cannot be ruled out but require more fine-tuning. Flux ratios between the different images are also derived and confirm flux anomalies with respect to estimates from lens models with smooth mass distributions. Based on observations made with the ESO-VLT, Paranal, Chile; Proposal 084.B-0013 (PI: Rix).Tables 2, 3 and Appendix A are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201423633/olm">http://www.aanda.org</A> [less ▲]

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See detailDynamic auroral storms on Saturn as observed by the Hubble Space Telescope
Nichols, J. D.; Badman, S. V.; Baines, K. H. et al

in Geophysical Research Letters (2014), 41

We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission ... [more ▼]

We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission observed at the poleward boundary of a solar wind-induced auroral storm, propagating at ˜330% rigid corotation from near ˜01 h LT toward ˜08 h LT. We suggest that these are indicative of ongoing, bursty reconnection of lobe flux in the magnetotail, providing strong evidence that Saturn's auroral storms are caused by large-scale flux closure. We also discuss the later evolution of a similar storm and show that the emission maps to the trailing region of an energetic neutral atom enhancement. We thus identify the auroral form with the upward field-aligned continuity currents flowing into the associated partial ring current. [less ▲]

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See detailForest radiative transfer models: which approach for which application?
Ligot, Gauthier ULg; Balandier, Philippe; Courbaud, Benoît et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2014), 44(5), 385-397

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See detailCassini nightside observations of the oscillatory motion of Saturn's northern auroral oval
Bunce, E. J.; Grodent, Denis ULg; Jinks, S. L. et al

in Journal of Geophysical Research. Space Physics (2014), 119

recent years we have benefitted greatly from the first in-orbit multi-wavelength images of Saturn's polar atmosphere from the Cassini spacecraft. Specifically, images obtained from the Cassini UltraViolet ... [more ▼]

recent years we have benefitted greatly from the first in-orbit multi-wavelength images of Saturn's polar atmosphere from the Cassini spacecraft. Specifically, images obtained from the Cassini UltraViolet Imaging Spectrograph (UVIS) provide an excellent view of the planet's auroral emissions, which in turn give an account of the large-scale magnetosphere-ionosphere coupling and dynamics within the system. However, obtaining near-simultaneous views of the auroral regions with in situ measurements of magnetic field and plasma populations at high latitudes is more difficult to routinely achieve. Here we present an unusual case, during Revolution 99 in January 2009, where UVIS observes the entire northern UV auroral oval during a 2 h interval while Cassini traverses the magnetic flux tubes connecting to the auroral regions near 21 LT, sampling the related magnetic field, particle, and radio and plasma wave signatures. The motion of the auroral oval evident from the UVIS images requires a careful interpretation of the associated latitudinally "oscillating" magnetic field and auroral field-aligned current signatures, whereas previous interpretations have assumed a static current system. Concurrent observations of the auroral hiss (typically generated in regions of downward directed field-aligned current) support this revised interpretation of an oscillating current system. The nature of the motion of the auroral oval evident in the UVIS image sequence, and the simultaneous measured motion of the field-aligned currents (and related plasma boundary) in this interval, is shown to be related to the northern hemisphere magnetosphere oscillation phase. This is in agreement with previous observations of the auroral oval oscillatory motion. [less ▲]

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See detailThe Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor Synthesis
Ponti, Donatella; Bellenchi, Gian Carlo; Puca, Rosa et al

in PLoS ONE (2014), 9(5),

EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the ... [more ▼]

EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the proliferation of stimulated cells or suppresses the tumorigenic growth of transformed cells. Upon interaction with ARF, EGR1 is sumoylated and acquires the ability to bind to specific targets such as PTEN and in turn to regulate cell growth. ARF is mainly localized to the periphery of nucleolus where is able to negatively regulate ribosome biogenesis. Since EGR1 colocalizes with ARF under IGF-1 stimulation we asked the question of whether EGR1 also relocate to the nucleolus to interact with ARF. Here we show that EGR1 colocalizes with nucleolar markers such as fibrillarin and B23 in the presence of ARF. Western analysis of nucleolar extracts from HeLa cells was used to confirm the presence of EGR1 in the nucleolus mainly as the 100 kDa sumoylated form. We also show that the level of the ribosomal RNA precursor 47S is inversely correlated to the level of EGR1 transcripts. The EGR1 iseffective to regulate the synthesis of the 47S rRNA precursor. Then we demonstrated that EGR1 binds to the Upstream Binding Factor (UBF) leading us to hypothesize that the regulating activity of EGR1 is mediated by its interaction within the transcriptional complex of RNA polymerase I. These results confirm the presence of EGR1 in the nucleolus and point to a role for EGR1 in the control of nucleolar metabolism. [less ▲]

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See detailLa radicalité ouvrière en mots et en actes. Polysémie des termes et disqualification politique
Geuens, Geoffrey ULg; Hamers, Jérémy ULg

in Quaderni : la Revue de la Communication (2014), 84 ("La radicalité ouvrière en Europe. Acteurs, pratiques, discours")(printemps 2014),

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See detailStratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectile
Sacre, Pierre-Yves ULg; Deconinck, Eric; Marini Djang'Eing'A, Roland ULg et al

in Spectra Analyse (2014), 43

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The ... [more ▼]

Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The present article reviews the main used techniques and concludes presenting a general strategy for the detection and handling of drug counterfeits. [less ▲]

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See detailCoupling building energy simulation and computational fluid dynamics: Application to a two-storey house in a temperate climate
Barbason, Mathieu ULg; Reiter, Sigrid ULg

in Building & Environment (2014), 75

This article reports the coupling of a building energy simulation (BES) made with TRNSYS with a computational fluid dynamics (CFD) simulation made with ANSYS FLUENT and its application to a typical ... [more ▼]

This article reports the coupling of a building energy simulation (BES) made with TRNSYS with a computational fluid dynamics (CFD) simulation made with ANSYS FLUENT and its application to a typical Belgian two-storey house. The coupling scheme developed in this study aims to improve the overheating prediction for buildings. This phenomenon is becoming increasingly frequent in Northern Europe due to increased insulation and a lack of sun protection and natural cooling strategies. Complementary contributions of the two numerical approaches are underlined and used to obtain accurate results in an acceptable computing time, even in a thermally stratified room. The space and time coupling is discussed to obtain an optimised tool in which BES is in charge of the primary portion of the effort, while CFD intervenes punctually on one room of interest. The numerical results are compared both qualitatively and quantitatively to the experimental results, and the improved accuracy of the coupled tool compared with a standalone BES is underlined. [less ▲]

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See detailA generic approach for solving nonlinear-discrete security-constrained power flow problems in large-scale systems
Platbrood, Ludovic; Capitanescu, Florin; Crisciu, Horia et al

in IEEE Transactions on Power Systems (2014), 29(3), 1194-1203

This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to ... [more ▼]

This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to identify the binding contingencies at the optimum, and a network compression method, used to reduce the complexity of the post-contingency models included in the SCOPF formulation. We show that by combining these two complementary ideas, it is possible to solve in a reasonable time SCOPF problems on large power system models with a large number of contingencies. Unlike most results reported for large-scale SCOPF problems, our algorithm uses a non-linear AC network model in both pre-contingency and post-contingency states, optimizes both active/reactive powers flows jointly, and treats the discrete variables. The proposed algorithm is implemented with state-of-the-art solvers and applied to two systems: a national grid with 2563 buses and 1297 contingencies, and a model of the European transmission network with 9241 buses and 12000 contingencies. [less ▲]

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See detailCan we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and facts
DELANAYE, Pierre ULg; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et al

in Nephrology Dialysis Transplantation (2014), 29(5), 997-1004

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]

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See detailLa spectroscopie proche infrarouge, une technique non destructive dans la lutte contre la contrefaçon des médicaments
Mbinze Kindenge, Jérémie ULg; Kalenda Tshilombo, Nicodème; Chavez, Pierre-François ULg et al

in Spectra Analyse (2014), 43

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of ... [more ▼]

Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of products. Indeed near infrared spectroscopy allows to perform fast, non-destructive, versatile analysis of the sample and minimization of the sample preparation. Based on those advantages, this spectroscopic method is one of the first reliable analytical techniques for fighting against counterfeit medicines. [less ▲]

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See detailMDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.
Shostak, Kateryna ULg; Patrascu, F.; Göktuna, Serkan ULg et al

in Cell death and differentiation (2014), 5(21), 811-24

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because ... [more ▼]

Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. Importantly, decreasing Mdm2 gene dosage in mouse mammary epithelial cells potentiates estrogen-dependent AKT activation owing to HPIP stabilization. In addition, we identified HPIP as a novel p53 transcriptional target, and pharmacological inhibition of MDM2 causes p53-dependent increase in HPIP transcription and also prevents HPIP degradation by turning off TBK1 activity. Our data indicate that p53 reactivation through MDM2 inhibition may result in ectopic AKT oncogenic activity by maintaining HPIP protein levels.Cell Death and Differentiation advance online publication, 31 January 2014; doi:10.1038/cdd.2014.2. [less ▲]

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See detailIs isokinetic eccentric exercise dangerous for the heart?
LE GOFF, Caroline ULg; Kaux, Jean-François ULg; LAURENT, Terry ULg et al

in Isokinetics & Exercise Science (2014), 22(2), 131-136

BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order ... [more ▼]

BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. OBJECTIVE: Our study aimed to observe the cardiovascular impact of a maximal intense isokinetic eccentric exercise performed by a population of sedentary young men. METHODS: Resting and post-exercise (just after, 3 hours and 24 hours after the exercise) blood samples were taken from 12 young male sedentary healthy subjects. These subjects performed an intense maximal eccentric isokinetic exercise of the quadriceps muscle.We evaluated markers of cardiovascular risk (troponin I, highly sensitive troponin T, NT-proBNP,myoglobin), of inflammation (hsCRP) and of oxidative stress (myeloperoxydase, lipidic peroxides, reduced and oxidized glutathione). RESULTS: The following observations were made: no significant increase in cardiac (NT-proBNP, troponins) or inflammation (hsCRP) biomarkers; a significant increase in myoglobin, myeloperoxidase, lipidic peroxides, oxidised glutathione just after the exercise. CONCLUSIONS: No modification in cardiac biomarkers were observed after the maximal eccentric isokinetic exercise. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. However, a significant level of oxidative stress was induced by this exercise. [less ▲]

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See detailCan we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and facts
DELANAYE, Pierre ULg; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et al

in Nephrology Dialysis Transplantation (2014), 29(5), 997-1004

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]

Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]

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See detailLe Pacifisme d'Auguste Beernaert. De l'homme d'Etat à l'homme des Etats
Genin, Vincent ULg

in Espace de Libertés : Magazine du Centre d'Action Laïque (2014), 429

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See detailDialectique de l'esthétique: Hans-Jürgen Krahl et le "marxisme occidental" entre art et politique.
Cavazzini, Andrea ULg; Hamers, Jérémy ULg

in Cahiers du GRM (2014), 5

L’article étudie – à partir des fragments de H.-J. Krahl – les débats sur l’esthétique et ses rapports avec la politique et la philosophie de l’histoire depuis la philosophie classique allemande jusqu’aux ... [more ▼]

L’article étudie – à partir des fragments de H.-J. Krahl – les débats sur l’esthétique et ses rapports avec la politique et la philosophie de l’histoire depuis la philosophie classique allemande jusqu’aux analyses post-adorniennes de l’industrie culturelle. [less ▲]

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See detailTowards a real time release approach for manufacturing tablets using NIR spectroscopy
Pestieau, Aude ULg; Krier, Fabrice ULg; Thoorens, Grégory et al

in Journal of Pharmaceutical & Biomedical Analysis (2014), 98

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See detailCapillary-driven bi-dimensional buoyancy in vertical soap films
Adami, Nicolas ULg; Caps, Hervé

in Europhysics Letters [=EPL] (2014)

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See detailStructured reflection breaks embedded in an online course – Effects on learning experience, time on task and performance
Verpoorten, Dominique ULg; Westera, Wim

in Interactive Learning Environments (2014)

The purpose of this paper is to gain insight into the effects of practicing short, frequent and structured reflection breaks interspersed with the learning material in a computer-based course. To that end ... [more ▼]

The purpose of this paper is to gain insight into the effects of practicing short, frequent and structured reflection breaks interspersed with the learning material in a computer-based course. To that end, the study sets up a standardised control trial with 2 groups of secondary-school pupils. The study shows that, while performance is not affected by these embedded “reflection rituals”, they significantly impact time on task and perceived learning. The study also suggests that the exposure to such built-in opportunities for reflection modifies the engagement with the content and fosters the claimed readiness for application of a similar reflective approach to learning in other occasions. [less ▲]

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See detailQuels types d'étude pour quels objectifs?
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Medi-Sphere (2014), 445

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See detailHigh resolution saturated hydraulic conductivity logging of friable to poorly indurated borehole cores using air permeability measurements
Rogiers, Bart; Winters, P.; Huysmans, Marijke et al

in Hydrogeology Journal (2014)

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates ... [more ▼]

Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater flow and contaminant transport in both unsaturated and saturated porous media. This paper investigates the hand-held air permeameter technique for high resolution hydraulic conductivity determination on borehole cores using a spatial resolution of ~0.05 m. We test the suitability of such air permeameter measurements on friable to poorly indurated sediments to improve the spatial prediction of classical laboratory based Ks measurements obtained at a much lower spatial resolution (~2 m). About 368 Ks measurements were made on ~350 m of borehole cores originating from the Campine basin, Northern Belgium, while ~5230 air permeability measurements were performed on the same cores. The heterogeneity in sediments, ranging from sand to clayey sand with distinct clay lenses, resulted in a Ks range of seven orders of magnitude. Cross-validation demonstrated that using air permeameter data as secondary variable and laboratory based Ks measurements as primary variable increased performance from R2 = 0.35 for ordinary kriging (laboratory Ks only) to R2 = 0.61 for co-kriging. Due to the large degree of small-scale variability detected by the air permeameter, the spatial granularity in the predicted laboratory Ks also increases drastically. The separate treatment of Kh and Kv revealed considerable anisotropy in certain lithostratigraphical units, while others where clearly isotropic at the sample scale. Air permeameter measurements on borehole cores provide a cost-effective way to improve spatial predictions of traditional laboratory based Ks. [less ▲]

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See detailThe XMM-Newton view of the yellow hypergiant IRC+10420 and its surroundings
De Becker, Michaël ULg; Hutsemekers, Damien ULg; Gosset, Eric ULg

in New Astronomy (2014), 29

Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by ... [more ▼]

Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by quite high mass loss episodes. Even though IRC+10420 benefited of many observations in several wavelength domains, it has never been a target for an X-ray observatory. We report here on the very first dedicated observation of IRC+10420 in X-rays, using the XMM-Newton satellite. Even though the target is not detected, we derive X-ray flux upper limits of the order of 1–3 ×10−14 erg cm−2 s−1 (between 0.3 and 10.0 keV), and we discuss the case of IRC+10420 in the framework of emission models likely to be adequate for such an object. Using the Optical/UV Monitor on board XMM-Newton, we present the very first upper limits of the flux density of IRC +10420 in the UV domain (between 1800 and 2250 Å and between 2050 and 2450 Å). Finally, we also report on the detection in this field of 10 X-ray and 7 UV point sources, and we briefly discuss their properties and potential counterparts at longer wavelengths. [less ▲]

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See detailComparison of implementation techniques for Galerkin projection between different meshes
Wang, Zifu; Henneron, Thomas; Dular, Patrick ULg et al

in International Journal of Numerical Modeling: Electronic Networks, Devices and Fields (2014), 27(3), 517-526

To solve multiphysics problems, weak coupling of finite element calculations can be carried out: the subproblems of which the physical nature differs are solved separately on their own meshes. In this ... [more ▼]

To solve multiphysics problems, weak coupling of finite element calculations can be carried out: the subproblems of which the physical nature differs are solved separately on their own meshes. In this case, Galerkin projection provides useful tool to ensure the transfer of physical fields between different meshes. In terms of implementation, the Galerkin projection system can be either accurately assembled over the intersection of two meshes or approximately integrated over the target mesh. This paper describes and compares these two implementation techniques for the Galerkin projection. [less ▲]

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See detailSur quelques thèmes chez Heiner Muller
Cavazzini, Andrea ULg

in Cahiers du GRM (2014), 5

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See detailHybrid MicroPET Imaging for Dosimetric Applications in Mice: Improvement of Activity Quantification in Dynamic MicroPET Imaging for Accelerated Dosimetry Applied to 6-[ 18 F] Fluoro- L -DOPA and 2-[ 18 F]Fluoro- L -Tyrosine
Bretin, Florian ULg; Mauxion, T; Warnock, G et al

in Molecular Imaging and Biology (2014), 16(3), 383-394

Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post ... [more ▼]

Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post scan harvested organs, can improve quantification. Organ harvesting, dynamic imaging and hybrid imaging were applied to determine the human and mouse radiation dosimetry of 6-[18 F]fluoro-L-DOPA and 2-[18 F]fluoro-L-tyrosine and compared. Procedures: Two-hour dynamic microPET imaging was performed with both tracers in four separate mice for 18 F-FDOPA and three mice for 18 F-FTYR. Organ harvesting was performed at 2, 5, 10, 30, 60 and 120 min post tracer injection with n=5 at each time point for 18 F-FDOPA and n=3 at each time point for 18 F-FTYR. Human radiation dosimetry projected from animal data was calculated for the three different approaches for each tracer using OLINDA/EXM. S- factors for the MOBY phantom were used to calculate the animal dosimetry. Results: Correlations between dose estimates based on organ harvesting and imaging was improved from r=0.997 to r=0.999 for 18 F-FDOPA and from r=0.985 to r=0.996 (p<0.0001 for all) for 18 F-FTYR by using hybrid imaging. Conclusion: Hybrid imaging yields comparable results to traditional organ harvesting while partially overcoming the limitations of pure imaging. It is an advantageous technique in terms of number of animals needed and labour involved. [less ▲]

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See detailSpatiotemporal monitoring of the antibiome secreted by Bacillus biofilms on plant roots using MALDI mass spectrometry imaging
Debois, Delphine ULg; Jourdan, Emmanuel; Smargiasso, Nicolas ULg et al

in Analytical Chemistry (2014), 86(9), 4431-4438

Some soil Bacilli living in association with plant roots can protect their host from infection by pathogenic microbes and are therefore being developed as biological agents to control plant diseases. The ... [more ▼]

Some soil Bacilli living in association with plant roots can protect their host from infection by pathogenic microbes and are therefore being developed as biological agents to control plant diseases. The plant protective activity of these bacteria has been correlated with the potential to secrete a wide array of antibiotic compounds upon growth as planktonic cells in isolated cultures under laboratory conditions. However, in situ expression of these antibiotics in the rhizosphere where bacterial cells naturally colonize root tissues is still poorly understood. In this work, we used Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) to examine spatio-temporal changes in the secreted antibiome of B. amyloliquefaciens developing as biofilms on roots. Non-ribosomal lipopeptides such as the plant immunity elicitor surfactin or the highly fungitoxic iturins and fengycins were readily produced albeit in different time-frames and quantities in the surrounding medium. Interestingly, MS/MS experiments performed directly from the gelified culture medium, also allowed to identify a new variant of surfactins released at later time points. However, no other bioactive compounds such as polyketides were detected at any time, strongly suggesting that the antibiome expressed in planta by B. amyloliquefaciens does not reflect the vast genetic arsenal devoted to the formation of such compounds. This first dynamic study reveals the power of MALDI MSI as tool to identify and map antibiotics synthesized by root-associated bacteria and more generally, to investigate plant-microbe interactions at the molecular level. [less ▲]

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See detailESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD - summary.
Ryden, Lars; Grant, Peter J.; Anker, Stefan D. et al

in Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease (2014), 11(3), 133-73

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See detailGenetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics
Gusareva, Elena ULg; Kurey, Irina; Grekov, Igor et al

in Biological Reviews of the Cambridge Philosophical Society (2014), 89(2), 375-405

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour ... [more ▼]

Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. [less ▲]

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See detailTransit confirmation and improved stellar and planet parameters for the super-Earth HD 97658 b and its host star
Van Grootel, Valérie ULg; Gillon, Michaël ULg; Valencia, D. et al

in Astrophysical Journal (2014), 786

Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition ... [more ▼]

Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition. We present here the confirmation, based on Spitzer transit observations, that the super-Earth HD 97658 b transits its host star. HD 97658 is a low-mass ($M_*=0.77\pm0.05\,M_{\odot}$) K1 dwarf, as determined from the Hipparcos parallax and stellar evolution modeling. To constrain the planet parameters, we carry out Bayesian global analyses of Keck-HIRES radial velocities, and MOST and Spitzer photometry. HD 97658 b is a massive ($M_P=7.55^{+0.83}_{-0.79} M_{\oplus}$) and large ($R_{P} = 2.247^{+0.098}_{-0.095} R_{\oplus}$ at 4.5 $\mu$m) super-Earth. We investigate the possible internal compositions for HD 97658 b. Our results indicate a large rocky component, by at least 60% by mass, and very little H-He components, at most 2% by mass. We also discuss how future asteroseismic observations can improve the knowledge of the HD 97658 system, in particular by constraining its age. Orbiting a bright host star, HD 97658 b will be a key target for coming space missions TESS, CHEOPS, PLATO, and also JWST, to characterize thoroughly its structure and atmosphere. [less ▲]

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See detailLivre et jeu vidéo. Introduction
Dozo, Björn-Olav ULg; Barnabé, Fanny ULg

in Mémoires du livre / Studies in Book Culture (2014), 5(2),

Introduction au numéro thématique "Livre et jeu vidéo" de la revue Mémoires du livre / Studies in book culture .

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See detailImplementing Human Rights in Benin: The Case of Inheritance Disputes
Andreetta, Sophie ULg

in Journal of Human Rights Practice (2014)

On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to ... [more ▼]

On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to focus on inheritance conflicts as a back door to questioning the implementation of a law directly inspired by international human rights standards and principles. When it comes to inheritance disputes, are human rights respected in Benin? What are the discourses of the judges, the lawyers, and the notaries regarding this new Code? How is it implemented and what are the obstacles to it? Combining both qualitative interviews with family members and participant observation in the courtrooms, I compiled a series of case studies, supplemented by interviews with judicial officials. These sets of data allowed me to grasp how laws are enforced and interpreted, and how citizens deal with their families and with the justice system. [less ▲]

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See detailL'articulation des règles fiscales anti-abus générales et spécifiques : essai de clarification
Bourgeois, Marc ULg; Nollet, Aymeric ULg

in Revue Générale du Contentieux Fiscal [=RGCF] (2014), 2014(3-4), 185-187

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See detailFactors associated with clinical inertia: an integrative review
Aujoulat, I; Jacquemin, p; Rietzschel, E et al

in Advances in Medical Education and Practice (2014), 5

Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is ... [more ▼]

Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is referred to as clinical inertia. However, the number and complexity of factors associated with the clinical reasoning that underlies the decision-making processes in medicine calls for a critical examination of the consistency of the concept. Indeed, in the absence of information on and justification of treatment decisions that were made, clinical inertia may be only apparent, and actually reflect good clinical practice. This integrative review seeks to address the factors generally associated with clinical inaction, in order to better delineate the concept of true clinical inertia. [less ▲]

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See detailA Brief Review of Ultraviolet Auroral Emissions on Giant Planets
Grodent, Denis ULg

in Space Science Reviews (2014)

The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although ... [more ▼]

The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although this simplified view is very handy for a gross depiction of the giant planets’ aurorae, it fails to scrutinize the diversity and the dynamics of the actual features that are regularly observed with the available ultraviolet imagers and spectrographs. In the present review, the typical morphologies of Jupiter and Saturn’s aurorae are represented with an updated and more accurate set of components. The use of sketches, rather than images, makes it possible to compile all these components in a single view and to put aside ultraviolet imaging technical issues that are blurring the emission sources, thus preventing one from disentangling the different auroral signatures. The ionospheric and magnetospheric processes to which these auroral features allude can then be more easily accounted. In addition, the use of components of the same kind for both planets may help to put forward similarities and differences between Jupiter and Saturn. The case of the ice giants Uranus and Neptune is much less compelling since their weak auroral emissions are very poorly documented and one can only speculate about their origin. This review presents a current perspective that will inevitably evolve in the future, especially with upcoming observing campaigns and forthcoming missions like Juno. [less ▲]

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See detailAnalyses croisées du monde du travail
Smette, Bernard ULg

in Cahiers du GRM (2014), 5

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See detailCoupling X-ray microtomography and macroscopic soil measurements: a method to enhance near saturation functions?
Beckers, Eléonore ULg; Plougonven, Erwan; Gigot, Nicolas et al

in Hydrology & Earth System Sciences (2014), 18

Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water ... [more ▼]

Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water retention and hydraulic conductivity curves using both classical soil techniques and X-ray microtomography in the context of tillage simplification. We show a good match for retention and conductivity functions between macroscopic measurements and microtomographic information. Microtomography highlights the presence of a secondary pore system. Analysis of structural parameters for these pores appears to be significant and offers additional clues for objects differentiation. We show that relatively fast scans supply not only good results, but also enhance near saturation characterization, making microtomography a highly competitive instrument for routine soil characterization. [less ▲]

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See detailProjected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)
Vrijens, Bernard ULg; Claeys, M.J.; LEGRAND, Victor ULg et al

in British Journal of Clinical Pharmacology (2014), 77(5), 746-755

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]

Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]

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See detailPompes à insuline, capteurs et activité physique. Existe t il des recommandations?
RADERMECKER, Régis ULg

in Diabète et Obésité (2014)

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See detailSelf-medication in persistent rhinitis: overuse of decongestants in half of the patients.
Mehuys, Els; Gevaert, Philippe; Brusselle, Guy et al

in Journal of Allergy and Clinical Immunology - In Practice (2014), 2(3), 313-319

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self ... [more ▼]

BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS: A cross-sectional observational study of individuals self-medicating persistent rhinitis (defined according to the Allergic Rhinitis and its Impact on Asthma guidelines). Participants (n = 895) completed a self-administered questionnaire to assess current symptoms, rhinitis medication, and previous physician diagnosis. Intranasal decongestant overuse was defined as daily use for at least 1 year. RESULTS: The vast majority of subjects (95%) had moderate-to-severe rhinitis. Nasal congestion was the predominant symptom (median visual analog scale, 6.6 cm; interquartile range, 3.4 cm). Sixty-five percent had had their current nasal problems for more than 5 years. Approximately 80% had a physician diagnosis (mainly allergic rhinitis or rhinosinusitis). The prevalence of intranasal decongestant overuse was high (49%), despite the fact that most of the patients (80%) were educated about the limit on duration of use. Use of intranasal glucocorticosteroids was inversely related to being an overuser (odds ratio 0.24 [95% CI, 0.17-0.35]). The risk of intranasal decongestant overuse also was reduced by use of other medications (oral H1 antihistamines and decongestants), use of nasal saline solution, and more symptoms of itchy and/or runny eyes or colored mucus. Risk was increased by a more severely blocked nose, longer duration of symptoms, the presence of sleep disturbance, higher body mass index, and previous advice to limit the duration of intranasal decongestant use. CONCLUSION: Half of the individuals self-medicating persistent rhinitis overused intranasal decongestants, despite the fact that they were educated about the limit on duration of use. [less ▲]

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See detailMéthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieure
Habyalimana, Védaste; Kalenda Tshilombo, Nicodème; Dispas, Amandine ULg et al

in Spectra Analyse (2014), 43

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class ... [more ▼]

Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class using an innovative strategy based on design of experiments followed in some cases by independent component analysis and calculation of design space. Once validated via the classical total error measurement approach, these methods were applied to quantify antimalarial, non-steroidal anti-inflammatory and antibiotic medicines. Alarming results regarding the dosage of these drugs widely used by people confirm the need to fight against this scourge. [less ▲]

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See detailLa radicalité ouvrière en Europe. Acteurs, pratiques, discours
Geuens, Geoffrey ULg; Hamers, Jérémy ULg

in Quaderni : la Revue de la Communication (2014), 84(printemps 2014),

En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait ... [more ▼]

En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait qualifier d’infrapolitique (« colère », « coup de sang », etc.). Un terme qualifie, très précisément, jusqu'à l'inflation rhétorique ces actions : « radicalité ». Ce dossier analyse les usages de la notion par divers acteurs (journalistes, juristes, politiques…), les liens entre radicalisation des registres d’action et luttes sociales, ainsi que les déterminants politiques, idéologiques et socio-culturels des discours fixant la frontière entre ce qui, dans une société donnée, relève de l'acceptable et de l'inacceptable. Contributeurs au dossier : G. Geuens et J. Hamers (Université de Liège, LEMME), A. Cavazzini (Groupe de Recherches Matérialistes), M. Jander (Freie Universität Berlin, Hamburger Institut für Sozialforschung) B. Carpenter (Duke University) et F.-W. Korsten (Erasmus University, University of Leiden), G. Cormann (Université de Liège), A. Mattoni et M. Vogiatzoglou (European University Institute). [less ▲]

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See detailDeterminant of fat mass percentage and absolute fat-free mass in preterm infants at the time of hospital discharge
Simon, Laure; Frondas-Chauty, Anne; SENTERRE, Thibault ULg et al

in American Journal of Clinical Nutrition (2014), 100(1), 98-104

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See detailTransiting hot Jupiters from WASP-South, Euler and TRAPPIST: WASP-95b to WASP-101b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2014)

We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of ... [more ▼]

We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of 0.5-2.8 MJup and radii of 1.1-1.4 RJup. The orbits of all the planets are compatible with zero eccentricity. WASP-99b produces the shallowest transit yet found by WASP-South, at 0.4 per cent. The host stars are of spectral type F2-G8. Five have metallicities of [Fe/H] from -0.03 to +0.23, while WASP-98 has a metallicity of -0.60, exceptionally low for a star with a transiting exoplanet. Five of the host stars are brighter than V = 10.8, which significantly extends the number of bright transiting systems available for follow-up studies. WASP-95 shows a possible rotational modulation at a period of 20.7 d. We discuss the completeness of WASP survey techniques by comparing to the HATnet project. [less ▲]

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See detailMicroRNA Targeting of CoREST controls polarization of migrating cortical neurons
Volvert; Prévot, Pierre-Paul; Close, Pierre ULg et al

in Cell Reports (2014), 7(4), 1168-83

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See detailEt si la promotion de la santé était un art du paradoxe !
Vandoorne, Chantal ULg

in Education Santé (2014), (300), 6-7

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See detailA new analysis of quasar polarization alignments
Pelgrims, Vincent ULg; Cudell, Jean-René ULg

in Monthly Notices of the Royal Astronomical Society (2014), 442(1), 1239-1248

We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that ... [more ▼]

We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that the distribution of polarization directions is random. This probability is found to be as low as 0,003 percent for one of the region of redshift. [less ▲]

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See detailRénover ou réformer la fiscalité du logement en Wallonie
Xhignesse, Guillaume ULg

in Revue Générale de Fiscalité [= RFG] (2014)

Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une ... [more ▼]

Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une telle réforme et nous proposons diverses pistes de réflexions. [less ▲]

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See detailX-ray microtomography: A porosity-based thresholding method to improve soil pore network characterization?
Beckers, Eléonore ULg; Plougonven, Erwan ULg; Roisin, Christian et al

in Geoderma (2014), 219-220

X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and ... [more ▼]

X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and processing choices are subjective and can have a strong impact on results and conclusions. In this study, we test a new method based on the porosity detectable by X-ray microtomography, while validation is achieved through comparison of soil microtomogram information with soil physical measurements. These measurements consist of water retention and unsaturated hydraulic conductivity using two different soil populations with only structural differences. To assess the porosity-based method performances, we compare it to four other methods, namely the global method of Otsu and three recent soil-dedicated local methods. The robustness of the porosity-based method is also tested in regard to different pre-processing procedures. In this paper we demonstrate that soil segmentation through a porosity-based method is an interesting issue. Indeed, it is less demanding in terms of time and computational requirements than its alternatives, and combines robustness and performances broadly comparable with the recent local methods. [less ▲]

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See detailLa Fête du 14 juillet à Liège vue par le consul de France Léon Labbé (1919-1930). Une célébration sous surveillance
Genin, Vincent ULg

in Bulletin de la Société Royale Le Vieux-Liège (2014), 344

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See detailAnalysis of the Shrinkage Effect on Mass Transfer During Convective Drying of Sawdust/Sludge Mixtures
Li, Jie ULg; Bennamoun, Lyes; Fraikin, Laurent ULg et al

in Drying Technology (2014), 32

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet ... [more ▼]

Convective drying of wastewater sludges and sawdust/sludge mixtures was studied. The first part of this work was an experimental study performed in a cross-flow convective dryer using 500 g of wet material extruded through a disk with circular dies of 12 mm. The results showed that the sawdust addition has a positive impact on the drying process from a mass ratio of 2/8, on a dry basis, with observed drying rates higher than the original sludge. The second part of this work consisted of developing a drying model in order to identify the internal diffusion coefficient and convective mass transfer coefficient from the experimental data. A comparison was made between fitted drying curves, well represented by the Newton’s model, and the analytical solutions of the diffusion equation applied to a finite cylinder. Variations of dimensional characteristics such as the volume and exchange surface of the sample bed were obtained by X-ray tomography. This technique allowed confirm that shrinkage, which is an important phenomenon occurring during sludge and sawdust/mixture drying, must be taken into account. The results showed that both the internal diffusion coefficient and convective mass transfer coefficient were affected by mixing and sawdust addition. The internal diffusion coefficient changed from 7.77×10-9 m2/s for the original sludge to 7.01×10-9 m2/s for the mixed sludge and then increased to 8.35×10-9 m2/s for the mixture of a mass ratio of 4/6. The convective mass transfer coefficient changed from 9.70×10-8 m/s for the original sludge to 8.67×10-8 m/s for the mixed sludge and then increased to 12.09×10-8 m/s for the mixture of a mass ratio of 4/6. These results confirmed that sawdust addition was beneficial to the sludge drying process as the mass transfer efficiency between the air and material increased. Reinforcing the texture of sludge by adding sawdust can increase the drying rate and decrease the drying time, and then the heat energy supply will be reduced significantly. The study also showed that neglecting shrinkage phenomenon resulted in an overestimation for the internal diffusion coefficient for the convective drying of sludges and sawdust/sludge mixtures. [less ▲]

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See detailPhysical forcing and physical/biochemical variability of the Mediterranean Sea: A review of unresolved issues and directions for future research
Malanotte-Rizzoli et al, Paula; Artale, V; Borzelli-Eusebi, G et al

in Ocean Science (2014), 10(3),

This paper is the outcome of a workshop held in Rome in November 2011 on the occasion of the 25th anniversary of the POEM (Physical Oceanography of the Eastern Mediterranean) program. In the workshop ... [more ▼]

This paper is the outcome of a workshop held in Rome in November 2011 on the occasion of the 25th anniversary of the POEM (Physical Oceanography of the Eastern Mediterranean) program. In the workshop discussions, a number of unresolved issues were identified for the physical and biogeochemical properties of the Mediterranean Sea as a whole, i.e., comprising the Western and Eastern sub-basins. Over the successive two years, the related ideas were discussed among the group of scientists who participated in the workshop and who have contributed to the writing of this paper. Three major topics were identified, each of them being the object of a section divided into a number of different sub-sections, each addressing a specific physical, chemical or biological issue: 1. Assessment of basin-wide physical/biochemical properties, of their variability and interactions. 2. Relative importance of external forcing functions (wind stress, heat/moisture fluxes, forcing through straits) vs. internal variability. 3. Shelf/deep sea interactions and exchanges of physical/biogeochemical properties and how they affect the sub-basin circulation and property distribution. Furthermore, a number of unresolved scientific/methodological issues were also identified and are reported in each sub-section after a short discussion of the present knowledge. They represent the collegial consensus of the scientists contributing to the paper. Naturally, the unresolved issues presented here constitute the choice of the authors and therefore they may not be exhaustive and/or complete. The overall goal is to stimulate a broader interdisciplinary discussion among the scientists of the Mediterranean oceanographic community, leading to enhanced collaborative efforts and exciting future discoveries [less ▲]

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See detailVitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiency
Djennane, M; Lebbah, S; Roux, C et al

in Osteoporosis International (2014), 25(5), 1493-502

Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25 ... [more ▼]

Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/L) was frequent, especially in winter. Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation Introduction As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter. As secondary objectives, we studied the various determinants of vitamin D status and the PTH-25OHD relationship in these subjects. Methods Four hundred thirty-five children 5–15 years old were examined and had a blood sample in September 2010. Of them, 408 were sampled again in March 2011. Results Median 25OHD concentration in the whole group was 71.4 nmol/L in September and 52.9 nmol/L in March. In September, 58.4, 29.9, and 8.1 % had a 25OHD concentration below 75, 50, and 30 nmol/L respectively. In March, these percentages increased to 65.2, 41.4, and 17.4 % for the 75, 50, and 30 nmol/L threshold, respectively. In multivariate analysis, older age, darker skin phototype, low daily vitamin D and calcium intake, poor socioeconomic status, and short daily sun exposure remained significantly associated with a 25OHD <50 nmol/L at both visits. In 72 (16.6 %) children, genu varum/valgum was present. Compared to the 363 children without leg deformation, they presented more frequently with the risk factors of vitamin D insufficiency. They also had lower 25OHD concentrations and higher PTH and tALP. Serum PTH and 25OHD concentrations were negatively and significantly correlated (r=−0.43; p<0.001) without a 25OHD threshold above which PTH does not decrease anymore. Conclusion Despite a sunny environment, vitamin D insufficiency is frequent in healthy Algerian children. [less ▲]

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See detailResilience to Flooding - Draft Building Code
Clarkson, John; Sullican, David; Braun, Kenton et al

in PIANC Yearbook 2013 (2014)

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See detailEditorial
Cavazzini, Andrea ULg

in Cahiers du GRM (2014), 5

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See detailLutter contre le fléau des médicaments contrefaits
Rudaz, Serge; Hubert, Philippe ULg

in Spectra Analyse (2014), 298

Editorial

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See detailHeterochrony in a complex world: disentangling environmental processes of facultative paedomorphosis in an amphibian
Denoël, Mathieu ULg; Ficetola, Gentile Francesco

in Journal of Animal Ecology (2014), 83(3), 606-615

1. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the ... [more ▼]

1. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the possibility to test hypotheses that could explain its success across environments. Amphibians are particularly suitable to exploring these questions because they express complex life cycles (i.e. metamorphosis) that have been disrupted by heterochronic processes (paedomorphosis: retention of larval traits in adults). The large phenotypic variation across populations suggests that more complex processes than expected are operating, but they remain to be investigated through multivariate analyses over a large range of natural populations across time. 2. In this study we compared the likelihood of multiple potential environmental determinants of heterochrony. We gathered data on the proportion of paedomorphic and metamorphic palmate newts (Lissotriton helveticus) across more than 150 populations during 10 years, and used an information-theoretic approach to compare the support of multiple potential processes. 3. Six environmental processes jointly explained the proportion of paedomorphs in populations: predation, water availability, dispersal limitation, aquatic breathing, terrestrial habitat suitability, and anti-predator refuges. Analyses of variation across space and time supported models based on the advantage of paedomorphosis in favourable aquatic habitats. 4. Paedomorphs were favoured in deep ponds, in conditions favourable to aquatic breathing (high oxygen content), with lack of fish, and surrounded by suitable terrestrial habitat. Metamorphs were favoured by banks allowing easy dispersal. 5. These results indicate that heterochrony relies on complex processes involving multiple ecological variables and exemplifies why heterochronic patterns occur in contrasted environments. On the other hand, the fast selection of alternative morphs shows that metamorphosis and paedomorphosis developmental modes could be easily disrupted in natural populations. [less ▲]

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See detailLe Musée de la Vie wallonne, indissociablement lié aux dialectologues liégeois
Frankinet, Baptiste ULg

in Culture, le Magazine Culturel de l'Université de Liège (2014)

Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce ... [more ▼]

Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce patrimoine dépassait le cadre strictement linguistique ou lexical pour épouser les formes d’un ensemble bien plus vaste : la vie wallonne tout entière. Impossible pour eux d’étudier un dialecte sans veiller à garder les usages ou les objets qu’il nomme, ni le souvenir des gens qui le parlent. Ainsi, en plus d’être des observateurs attentifs à leurs propres parlers, ils devinrent les premiers conservateurs de leur région. [less ▲]

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See detailDes performances de production laitière et de reproduction élevées sont compatibles. Le management en est la clé.
Chapaux, Philippe; Glorieux, Géry; Hanzen, Christian ULg

in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)

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See detailImplementation of a non-orthogonal constitutive model for the finite element simulation of textile composite draping
Pierce, Robert S; Falzon, Brian G; Thompson, Mark C et al

in Applied Mechanics and Materials (2014), 553

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This ... [more ▼]

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This paper focuses on the continuum-based, finite element modelling of textile composites as they deform during the draping process. A non-orthogonal constitutive model tracks yarn orientations within a material subroutine developed for Abaqus/Explicit, resulting in the realistic determination of fabric shearing and material draw-in. Supplementary material characterisation was experimentally performed in order to define the tensile and non-linear shear behaviour accurately. The validity of the finite element model has been studied through comparison with similar research in the field and the experimental lay-up of carbon fibre textile reinforcement over a tool with double curvature geometry, showing good agreement. [less ▲]

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See detailAnalysis of transient scattering problems using a discontinuous Galerkin method: application to the shielding effectiveness of enclosures with heterogeneous walls
Boubekeur, Mohamed; Kameni, Abelin; Pichon, Lionel et al

in International Journal of Numerical Modelling: Electronic Networks, Devices and Fields (2014), 27(3), 626-635

In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized ... [more ▼]

In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized parameters given by Maxwell-Garnett rules in the frequency domain are tested in the time domain using a nodal discontinuous Galerkin method, which uses an interface condition based on analytical solution in the frequency domain to replace a conductive sheet. This interface condition allows to avoid meshing the thin sheet, thus reducing the computational cost. Results of scattering by composite enclosures are presented in the frequency domain thanks to a Fast Fourier Transform. [less ▲]

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See detailShewhart Control Charts for Monitoring Reliability with Weibull Lifetimes
Faraz, Alireza ULg; Saniga, Erwin; Heuchenne, Cédric ULg

in Quality and Reliability Engineering International (2014)

In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method ... [more ▼]

In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method is its ease of use and flexibility for the case where the process distribution is Weibull, although the method can be applied to any distribution. We illustrate the performance of our method through simulation and the application through the use of an actual data set. Our results indicate that Z ̅ and S2 control charts perform well in detecting shifts in the scale and shape parameters. We also provide a guide that would enable a user to interpret out-of-control signals. [less ▲]

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See detailAngles corniculaires et de demi-cercle chez Euclide
Bair, Jacques ULg; Henry, Valérie ULg

in Hors Série Tangente (2014), 53

Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le ... [more ▼]

Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le concept d'angle et sa distinction entre les angles rectilignes et mixtilignes. Les cas des angles corniculaires et de demi-cercle sont spécialement traités. [less ▲]

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See detailInfluence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituents
Verstringe, Stefanie; Danthine, Sabine ULg; Blecker, Christophe ULg et al

in Food Research International (2014), 62

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]

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See detailInfluence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituents
Verstringe, Stefanie; Danthine, Sabine ULg; Blecker, Christophe ULg et al

in Food Research International (2014), 62

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]

The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]

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See detailLong-wave infrared digital holographic interferometry with diffuser or point source illuminations for measuring deformations of aspheric mirrors
Vandenrijt, Jean-François ULg; Thizy, Cédric ULg; Queeckers, Patrick et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2014), 53(11), 112309

Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a ... [more ▼]

Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a Mach–Zehnder, associated to the digital holography reconstruction of the wavefront in the inline configuration with phase shifting. Two possibilities exist for illuminating the tested reflector: either with a point source (similarly to classical interferometry) or an extended source (with a diffuser). This paper presents the development of a modular setup which allows comparing both in the case of a parabolic mirror [less ▲]

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See detailAltered Desferrioxamine-mediated Iron Utilization is a Common Trait of bald Mutants of Streptomyces coelicolor
Lambert, Stéphany ULg; Traxler, Matthew F; Craig, Matthias et al

in Metallomics (2014)

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See detailPoly(methyl methacrylate)/graphene oxide nanocomposites by a precipitation polymerization process and their dielectric and rheological characterization
Thomassin, Jean-Michel ULg; Trifkovic, Milana; Alkarmo, Walid et al

in Macromolecules (2014), 47(6), 2149-2155

We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a ... [more ▼]

We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a surfactant and adsorbs on the interface between polymerized PMMA particles and solvent mixture. Scanning electron and transmission electron microscopy confirmed that the precipitate consists of polymer particles (<1 μm) surrounded by the GO sheets. Compression molding of the precipitate yields a polymer nanocomposite with the GO organized into a regularly spaced 3D network which percolates at 0.2 wt % GO. Simple thermal reduction of the GO sheets dispersed in PMMA at relatively low temperature (210 °C) achieved electrical conductivity higher than 10−2 S/m at 0.4 wt % of GO. Parallel dielectric and rheological characterization demonstrated that the thermal reduction is a quite fast process without significant degradation of the polymer. The study should open up new opportunities in the design of GO-based polymer nanocomposites. [less ▲]

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See detailBrown rust disease control in winter wheat: II. Exploring the optimization of fungicide sprays through a decision support system
El Jarroudi, Moussa ULg; kOUADIO, Louis; Giraud, Frédéric et al

in Environmental Science & Pollution Research (2014), 21(4), 4809-4818

A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall ... [more ▼]

A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall) and a mechanistic model for leaf emergence and development simulation (i.e., PROCULTURE) was tested in order to schedule fungicide time spray for controlling leaf rust progress in wheat fields. Experiments including a single fungicide treatment based upon the DSS along with double and triple treatment were carried out over the 2007–2009 cropping seasons in four representative Luxembourgish wheat field locations. The study showed that the WLR occurrences and severities differed according to the site, cultivar, and year. We also found out that the single fungicide treatment based on the DSS allowed a good protection of the three upper leaves of susceptible cultivars in fields with predominant WLR occurrences. The harvested grain yield was not significantly different from that of the double and triple fungicide-treated plots (P < 0.05). Such results could serve as basis or be coupled to cost-effective and environmentally friendly crop management systems in operational context. [less ▲]

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See detailStochastic exposure to sub-lethal high temperature enhances exopolysaccharides (EPS) excretion and improves Bifidobacterium bifidum cell survival to freeze-drying
Nguyen, Huu Thanh ULg; Razafindralambo, Hary; Blecker, Christophe ULg et al

in Biochemical Engineering Journal (2014), 88

Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal ... [more ▼]

Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal temperature stresses has been used in order to investigate the response of the stress sensitive Bifidobacterium bifidum THT 0101 to downstream processing operations. A stochastic model validated by residence time distribution experiments has shown that in the heat-shock configuration, a two-compartment bioreactor (TCB) allows the exposure of microbial cells to sub-lethal temperature of 42°C for a duration comprised between 100 and 300 seconds. This exposure resulted in a significant increase of cell resistance to freeze-drying by comparison with cells cultivated in conventional bioreactors or in the TCB in the cold shock mode (CS-TCB). The mechanism behind this robustness seems to be related with the coating of microbial cells with exopolysaccharide (EPS), as assessed by the change of the zeta potential and the presence of higher EPS concentration after heat shock. Conditioning of Bifidobacteria on the basis of the heat shock technique is interesting from the practical and economical point of view since this strategy can be directly implemented in the bioreactor during stationary phase preceding cell recovery and freeze-drying [less ▲]

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See detailDavid Knoke, Economic networks
Dufays, Frédéric ULg

in Lectures (2014)

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See detailElaboration of drug nanocarriers based on a glucosamine labeled amphiphilic polymer
Boyère, Cédric; Duhem, N; Debuigne, Antoine ULg et al

in Polymer Chemistry (2014), 5(8), 3030-3037

A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG ... [more ▼]

A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG-GlcNH2). A synthesis strategy combining enzymatic and metal-free click chemistry was developed in order to meet the increasingly stringent requirements of biomedical applications. After the self-assembly of the Chol-PEG-GlcNH2 amphiphilic polymer in water, the presence of glucosamine at the micelle surface confers an active targeting moiety to the nanocarriers whereas protonation of the peripheral primary amine delay their aggregation. The complete characterization of this novel functional amphiphilic bioconjugate is presented as well as its aqueous solution behaviour and encapsulation efficiency using ketoconazole as a model hydrophobic drug. [less ▲]

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