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See detailPeculiar architectures for the WASP-53 and WASP-81 planet-hosting systems★
Triaud, Amaury H. M. J.; Neveu-VanMalle, Marion; Lendl, Monika et al

in Monthly Notices of the Royal Astronomical Society (2017), 467

We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the ... [more ▼]

We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the photometric signals were indeed produced by two transiting hot Jupiters. Our observations also show the presence of additional Doppler signals. In addition to short-period hot Jupiters, we find that the WASP-53 and WASP-81 systems also host brown dwarfs, on fairly eccentric orbits with semimajor axes of a few astronomical units. WASP-53c is over 16 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB] and WASP-81c is 57 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB]. The presence of these tight, massive companions restricts theories of how the inner planets were assembled. We propose two alternative interpretations: the formation of the hot Jupiters within the snow line or the late dynamical arrival of the brown dwarfs after disc dispersal. We also attempted to measure the Rossiter-McLaughlin effect for both hot Jupiters. In the case of WASP-81b, we fail to detect a signal. For WASP-53b, we find that the planet is aligned with respect to the stellar spin axis. In addition we explore the prospect of transit-timing variations, and of using Gaia's astrometry to measure the true masses of both brown dwarfs and also their relative inclination with respect to the inner transiting hot Jupiters. [less ▲]

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See detailThe Spitzer search for the transits of HARPS low-mass planets. II. Null results for 19 planets
Gillon, Michaël ULiege; Demory, B.-O.; Lovis, C. et al

in Astronomy and Astrophysics (2017), 601

Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of ... [more ▼]

Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of objects suitable for detailed characterization. Searching for the transits of the low-mass planets detected by Doppler surveys is a straightforward way to achieve this goal. Indeed, Doppler surveys target the most nearby main-sequence stars, they regularly detect close-in low-mass planets with significant transit probability, and their radial velocity data constrain strongly the ephemeris of possible transits. In this context, we initiated in 2010 an ambitious Spitzer multi-Cycle transit search project that targeted 25 low-mass planets detected by radial velocity, focusing mainly on the shortest-period planets detected by the HARPS spectrograph. We report here null results for 19 targets of the project. For 16 planets out of 19, a transiting configuration is strongly disfavored or firmly rejected by our data for most planetary compositions. We derive a posterior probability of 83% that none of the probed 19 planets transits (for a prior probability of 22%), which still leaves a significant probability of 17% that at least one of them does transit. Globally, our Spitzer project revealed or confirmed transits for three of its 25 targeted planets, and discarded or disfavored the transiting nature of 20 of them. Our light curves demonstrate for Warm Spitzer excellent photometric precisions: for 14 targets out of 19, we were able to reach standard deviations that were better than 50 ppm per 30 min intervals. Combined with its Earth-trailing orbit, which makes it capable of pointing any star in the sky and to monitor it continuously for days, this work confirms Spitzer as an optimal instrument to detect sub-mmag-deep transits on the bright nearby stars targeted by Doppler surveys. The photometric and radial velocity time series used in this work are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117</A> [less ▲]

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See detailAn Optical and Infrared Photometric Study of the Young Open Cluster IC 1805 in the Giant H ii Region W4 †
Sung, Hwankyung; Bessell, Michael S.; Chun, Moo-Young et al

in Astrophysical Journal Supplement Series (2017), 230

We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from ... [more ▼]

We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from their location in the various color–color and color–magnitude diagrams, and the presence of Hα emission, mid-infrared excess emission, and X-ray emission. The reddening law toward IC 1805 is nearly normal (R [SUB] V [/SUB] = 3.05 ± 0.06). However, the distance modulus of the cluster is estimated to be 11.9 ± 0.2 mag (d=2.4+/- 0.2 kpc) from the reddening-free color–magnitude diagrams, which is larger than the distance to the nearby massive star-forming region W3(OH) measured from the radio VLBA astrometry. We also determined the age of IC 1805 ({τ }[SUB]{MSTO[/SUB]}=3.5 Myr). In addition, we critically compared the age and mass scale from two pre-main-sequence evolution models. The initial mass function with a Salpeter-type slope of Γ = ‑1.3 ± 0.2 was obtained and the total mass of IC 1805 was estimated to be about 2700 ± 200 {M}[SUB]ȯ [/SUB]. Finally, we found our distance determination to be statistically consistent with the Tycho-Gaia Astrometric Solution Data Release 1, within the errors. The proper motion of the B-type stars shows an elongated distribution along the Galactic plane, which could be explained by some of the B-type stars being formed in small clouds dispersed by previous episodes of star formation or supernova explosions. The optical imaging data in this article were gathered with two facilities: the AZT-22 1.5 m telescope at Maidanak Astronomical Observatory in Uzbekistan and the Canada–France–Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l’Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. [less ▲]

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See detailHow unique is Plaskett's star? A search for organized magnetic fields in short period, interacting or post-interaction massive binary systems★
Nazé, Yaël ULiege; Neiner, Coralie; Grunhut, Jason et al

in Monthly Notices of the Royal Astronomical Society (2017), 467

Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have ... [more ▼]

Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have occurred in this system, one may wonder about their potential role in generating magnetic fields. Stokes V spectra collected with the low-resolution FORS2 and high-resolution ESPaDOnS and Narval spectropolarimeters were therefore used to search for magnetic fields in 15 interacting or post-interaction massive binaries. No magnetic field was detected in any of them, with 0 G always being within 2σ of the derived values. For 17 out of 25 stars in the systems observed at high resolution, the 90 per cent upper limit on the individual dipolar fields is below the dipolar field strength of Plaskett's secondary; a similar result is found for five out of six systems observed at low resolution. If our sample is considered to form a group of stars sharing similar magnetic properties, a global statistical analysis results in a stringent upper limit of ∼200 G on the dipolar field strength. Moreover, the magnetic incidence rate in the full sample of interacting or post-interaction systems (our targets + Plaskett's star) is compatible with that measured from large surveys, showing that they are not significantly different from the general O-star population. These results suggest that binary interactions play no systematic role in the magnetism of such massive systems. [less ▲]

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See detailThe HARPS search for southern extra-solar planets. XXXVI. Eight HARPS multi-planet systems hosting 20 super-Earth and Neptune-mass companions
Udry, S.; Dumusque, X.; Lovis, C. et al

in ArXiv e-prints (2017), 1705

We present radial-velocity measurement of eight stars observed with the HARPS Echelle spectrograph mounted on the 3.6-m telescope in La Silla (ESO, Chile). Data span more than ten years and highlight the ... [more ▼]

We present radial-velocity measurement of eight stars observed with the HARPS Echelle spectrograph mounted on the 3.6-m telescope in La Silla (ESO, Chile). Data span more than ten years and highlight the long-term stability of the instrument. We search for potential planets orbiting HD20003, HD20781, HD21693, HD31527, HD45184, HD51608, HD134060 and HD136352 to increase the number of known planetary systems and thus better constrain exoplanet statistics. After a preliminary phase looking for signals using generalized Lomb-Scargle periodograms, we perform a careful analysis of all signals to separate \emph{bona-fide} planets from spurious signals induced by stellar activity and instrumental systematics. We finally secure the detection of all planets using the efficient MCMC available on the Data and Analysis Center for Exoplanets (DACE web-platform), using model comparison whenever necessary. In total, we report the detection of twenty new super-Earth to Neptune-mass planets, with minimum masses ranging from 2 to 30 M$_{\rm Earth}$, and periods ranging from 3 to 1300 days. By including CORALIE and HARPS measurements of HD20782 to the already published data, we also improve the characterization of the extremely eccentric Jupiter orbiting this host. [less ▲]

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See detailπ Aquarii is another γ Cassiopeiae object
Nazé, Yaël ULiege; Rauw, Grégor ULiege; Cazorla, Constantin ULiege

in Astronomy and Astrophysics (2017), 602

The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly ... [more ▼]

The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly make this Be star another member of the γ Cas category. Furthermore, π Aqr is a binary but, contrary to γ Cas, the nature of the companion to the Be star is known; it is a non-degenerate (stellar) object and its small separation from the Be star does not leave much room for a putative compact object close to the Be disk. This renders the accretion scenario difficult to apply in this system, and, hence, this discovery favors a disk-related origin for the γ Cas phenomenon. Based on observations collected with the ESA science mission XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA). [less ▲]

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See detailIn vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical review
Pestieau, Aude ULiege; Evrard, Brigitte ULiege

in European Journal of Pharmaceutical Sciences (2017), 102

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]

For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]

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See detailMulti-phase volcanic resurfacing at Loki Patera on Io
de Kleer, K.; Skrutskie, M.; Leisenring, J. et al

in Nature (La) (2017), 545

The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21 ... [more ▼]

The Jovian moon Io hosts the most powerful persistently active volcano in the Solar System, Loki Patera. The interior of this volcanic, caldera-like feature is composed of a warm, dark floor covering 21,500 square kilometres surrounding a much cooler central ‘island’. The temperature gradient seen across areas of the patera indicates a systematic resurfacing process, which has been seen to occur typically every one to three years since the 1980s. Analysis of past data has indicated that the resurfacing progressed around the patera in an anti-clockwise direction at a rate of one to two kilometres per day, and that it is caused either by episodic eruptions that emplace voluminous lava flows or by a cyclically overturning lava lake contained within the patera. However, spacecraft and telescope observations have been unable to map the emission from the entire patera floor at sufficient spatial resolution to establish the physical processes at play. Here we report temperature and lava cooling age maps of the entire patera floor at a spatial sampling of about two kilometres, derived from ground-based interferometric imaging of thermal emission from Loki Patera obtained on 8 March 2015 UT as the limb of Europa occulted Io. Our results indicate that Loki Patera is resurfaced by a multi-phase process in which two waves propagate and converge around the central island. The different velocities and start times of the waves indicate a non-uniformity in the lava gas content and/or crust bulk density across the patera. [less ▲]

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See detailComparative assessment of 6-[18F]fluoro-L-m-tyrosine and 6-[18F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson’s disease rat model.
Becker, Guillaume ULiege; Bahri, Mohamed Ali ULiege; Michel, Anne et al

in Journal of Neurochemistry (2017), 141

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]

Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, we hypothesized that the latter would show stronger relationship with behavioural and post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method. Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum using the tissue-derived uptake rate constant Kc. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study indicates that the [18F]FMT could be more sensitive, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]

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See detailTransparent Electrodes Based on Silver Nanowire Networks: From Physical Considerations towards Device Integration
Bellet, Daniel; Lagrange, Mélanie; Sannicolo, Thomas et al

in Materials (2017), 10

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells ... [more ▼]

The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells, flexible light-emitting devices, touch screens, electromagnetic devices, and flexible transparent thin film heaters. Currently, the most commonly used TCM for such applications (ITO: Indium Tin oxide) suffers from two major drawbacks: brittleness and indium scarcity. Among emerging transparent electrodes, silver nanowire (AgNW) networks appear to be a promising substitute to ITO since such electrically percolating networks exhibit excellent properties with sheet resistance lower than 10 Ω/sq and optical transparency of 90%, fulfilling the requirements of most applications. In addition, AgNW networks also exhibit very good mechanical flexibility. The fabrication of these electrodes involves low-temperature processing steps and scalable methods, thus making them appropriate for future use as low-cost transparent electrodes in flexible electronic devices. This contribution aims to briefly present the main properties of AgNW based transparent electrodes as well as some considerations relating to their efficient integration in devices. The influence of network density, nanowire sizes, and post treatments on the properties of AgNW networks will also be evaluated. In addition to a general overview of AgNW networks, we focus on two important aspects: (i) network instabilities as well as an efficient Atomic Layer Deposition (ALD) coating which clearly enhances AgNW network stability and (ii) modelling to better understand the physical properties of these networks. [less ▲]

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See detailCo-creating service recovery after service failure: The role of brand equity
Hazee, Simon ULiege; Van Vaerenbergh, Yves; Armirotto, Vincent

in Journal of Business Research (2017), 74

Co-creating service recovery with customers has recently appeared as a new perspective in service research. Prior research demonstrates the effectiveness of co-created recovery strategies in driving ... [more ▼]

Co-creating service recovery with customers has recently appeared as a new perspective in service research. Prior research demonstrates the effectiveness of co-created recovery strategies in driving customer outcomes, and out- lines when co-creating a service recovery is recommended. This paper complements prior research not only by demonstrating the mediating role of outcome favorability in the relationship between co-created service recov- ery and customer outcomes, but also by showing whether organizations with different levels of brand equity benefit equally from co-creating service recovery with their customers. The results of two experiments show that co-creating a service recovery makes customers believe they received the most favorable solution for the ser- vice failure, which in turn influences satisfaction with service recovery and repurchase intentions. In addition, co- creating a service recovery is recommended for organizations with low levels of brand equity, but not for orga- nizations with high levels of brand equity. [less ▲]

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See detailMild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytes
Demine, Stéphane; Tejerina, Silvia; Bihin, Benoît et al

in Journal of Cellular Physiology (2017)

Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet ... [more ▼]

Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet-associated proteins as well as lipolytic enzymes have been identified. Increasing energy expenditure by inducing a mild uncoupling of mitochondria in adipocytes might represent a putative interesting anti-obesity strategy as it reduces the adipose tissue triacylglycerol content (limiting alterations caused by cell hypertrophy) by stimulating lipolysis through yet unknown mechanisms, limiting the adverse effects of adipocyte hypertrophy. Herein, the molecular mechanisms involved in lipolysis induced by a mild uncoupling of mitochondria in white 3T3-L1 adipocytes were characterized. Mitochondrial uncoupling-induced lipolysis was found to be independent from canonical pathways that involve lipolytic enzymes such as HSL and ATGL. Finally, enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles. This new mechanism of triacylglycerol breakdown in adipocytes exposed to mild uncoupling provides new insights on the biology of adipocytes dealing with mitochondria forced to dissipate energy. [less ▲]

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See detailEffect of Multicolumn Lead Spinal Cord Stimulation on Low Back Pain in Failed Back Surgery Patients: A Three-Year Follow-Up
Remacle, Thibault ULiege; BONHOMME, Vincent ULiege; Renwart, Henri-Jean et al

in Neuromodulation (2017)

OBJECTIVES:Spinal cord stimulation (SCS) remains poorly efficient at reducing back pain in failed back surgery syndrome (FBSS) patients. We aimed at determining whether a new multicolumn lead SCS ... [more ▼]

OBJECTIVES:Spinal cord stimulation (SCS) remains poorly efficient at reducing back pain in failed back surgery syndrome (FBSS) patients. We aimed at determining whether a new multicolumn lead SCS technique was efficient at durably reducing their leg (LP) and back (BP) pain. MATERIALS AND METHODS:Sixty-two consecutive refractory FBSS patients received multicolumn SCS. Visual analogue scale (VAS) self-evaluation of BP, LP, and limitation of daily activity (LAD) were recorded preoperatively and at 2, 6, 12, 24, and 36 months after surgery. Quality of sleep and use of concomitant medications were also recorded. RESULTS:Complete datasets were obtained in 29 patients. BP (median VAS [25-75 centiles]) significantly decreased from 9 (8.5-10) preoperatively, to 3 (3-4) at short-term follow-up (2 months), and rose up to 5 (4-5) at 36 months. LP evolved from 7 (6-8) preoperatively, to 2.5 (2-3) at short-term follow-up, and 3 (2-3) at 36 months. Correspondingly, LAD VAS was 8 (8-9) preoperatively, and decreased to stable values of 3 (3-4) during the follow-up period. Quality of sleep also improved, with 72% of patients reporting poor sleep preoperatively to 0-7% in the follow-up period until 36 months. The percentages of patients regularly taking analgesic and/or co-analgesic medications decreased from 100% preoperatively to 8, 4, 12, 19, and 19%. CONCLUSION:Multicolumn lead SCS in FBSS patients significantly improve BP, LP, quality of life, and medication consumption for at least 36 months. A classical placebo effect cannot account for long-term improvements of such magnitude. [less ▲]

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See detailPremière consultation ambulatoire du nouveau-né
RIGO, Vincent ULiege; PIELTAIN, Catherine ULiege; Schoffeniels, Colombe et al

in Revue Médicale de Liège (2017), 72(5), 253-259

The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate ... [more ▼]

The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate feedings are checked. Sudden infant death syndrome prevention and security advices are reminded. Realisation of both neonatal dried blood screen and hearing test is confirmed, as well as planning of specific follow-up appointments. The physical exam will focus on red flags for diseases or malformations with a delayed presentation. [less ▲]

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See detailThe exclusion of competing one-way essential complements: implications for net neutrality
Broos, Sébastien ULiege; Gautier, Axel ULiege

in International Journal of Industrial Organization (2017), 52

We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A ... [more ▼]

We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A typical example is the exclusion of VoIP applications by telecom companies offering internet and voice services. A monopoly ISP may want to exclude a competing internet app if it is of inferior quality and the ISP cannot ask for a surcharge for its use. Competition between ISPs never leads to full app exclusion but it may lead to a fragmented internet where only one ISP offers the application. We show that, both in monopoly and duopoly, prohibiting the exclusion of the app and surcharges for its use does not always improve welfare. [less ▲]

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See detailModeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropy
van den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric ULiege et al

in Computers and Geotechnics (2017), 85

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See detailMerci à vous!
RADERMECKER, Régis ULiege

in Revue de l'Association Belge du Diabète (2017), 60(3),

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See detailQuand la recherche et la clinique se rencontrent: Présentation du programme ces années incroyables comme expérience pilote au sein d'une équipe SOS-Enfants
Mathys, Cécile ULiege; Boulard, Aurore ULiege

in Carnet de Notes sur les Maltraitances Infantiles (2017), 6

Le travail avec les parents est un des enjeux majeurs des équipes SOS-Enfants. Cet article se propose de présenter le contenu d’une intervention cognitivo-comportementale destinée à développer les ... [more ▼]

Le travail avec les parents est un des enjeux majeurs des équipes SOS-Enfants. Cet article se propose de présenter le contenu d’une intervention cognitivo-comportementale destinée à développer les habiletés parentales (le programme “ces années incroyables”) et les premières observations liées à son implantation au sein d’une équipe SOS-Enfants. 5 mères (X âge = 40 ans, Ec.type = 7,1) ont participé à cette expérimentation sur une durée de 12 semaines avec pour objectifs: 1. développer une relation parent-enfant harmonieuse ; 2. l’apprentissage de stratégies éducatives efficaces et utilisées de façon cohérente ; 3. améliorer les processus de résolution de problèmes et la communication au sein de la famille. Les éléments de contenu et du dispositif de l’intervention qui ont été mis en évidence par les mères comme étant significatifs pour atteindre ces objectifs sont exposés. L’article se termine par une mise en perspective et des propositions concrètes pour développer ce type d’intervention au sein des équipes SOS-Enfants. [less ▲]

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See detailFrom distant neighbours to bedmates: Exploring the synergies between the social economy and sustainable development
Hudon, Marek; Huybrechts, Benjamin ULiege

in Annals of Public and Cooperative Economics (2017), 88(2), 141-154

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two ... [more ▼]

To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two research fields and the increasing combination of these fields in the literature. Several avenues through which social enterprises can contribute to the transition towards sustainable development are then identified. This is followed by a discussion of how and why the combination can be particularly fruitful both for the social economy and for sustainability transition movements. We also highlight some important challenges facing the social economy with regard to its contribution to sustainable development. Finally we introduce the papers that constitute this special issue and show how they contribute, individually and collectively, to a better understanding of the increasing linkage between the social economy and sustainable development. [less ▲]

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See detailGestion d’un cas de brûlure étendue suite à une chirurgie de convenance
Picavet, Pierre ULiege; Jacobs, Morgane ULiege; Noël, Stéphanie ULiege et al

in Monde Vétérinaire (Le) (2017), 169

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See detailDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics
Degueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et al

in Toxicon (2017), 130

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]

Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]

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See detailLes pouvoirs publics et les édifices cultuels en Belgique
Husson, Jean-François ULiege

in Revue du Droit des Religions (2017), (3), 61-78

The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions ... [more ▼]

The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions are essentially a legacy of the French Concordat, largely unchallenged by the regionalization process. Today, it has to respond to contrasting situations between religions recognized in the 19th century – generally declining – and more recently recognized ones – generally expanding –. An additional complication originates in differences in ownership of the buildings or their classification as listed buildings. After presenting the situation by religious and philosophical community and level of power, this paper questions the equity of the system and addresses the possible developments. [less ▲]

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See detailEccentric training for tendon healing after lesion: a rat model
Kaux, Jean-François ULiege; Libertiaux, Vincent ULiege; Leprince, Pierre ULiege et al

in American Journal of Sports Medicine (2017), 45(6), 1440-1446

BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore ... [more ▼]

BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore, eccentric exercise seems to improve the mechanical quality of the tendon. HYPOTHESIS:A combination of PRP injection and eccentric training might be more effective than either treatment alone. STUDY DESIGN:Controlled laboratory study. METHODS:Adult male rats were anesthetized, an incision was performed in the middle of their left patellar tendon and an injection of physiological fluid (PF) or homologous PRP was randomly made at the lesion level. The rats were then divided into 2 groups: the eccentric group, undergoing eccentric training 3 times a week, and the untrained group, without any training. Thus, 4 groups were compared. After 5 weeks, the tendons were removed and their ultimate tensile strength and energy were measured. Tendons were frozen for proteomic analyses when all biomechanical tests were completed. Statistical analysis was performed with linear mixed effect models. RESULTS:No significant difference was found between the treatments using PF injection or PRP injection alone. However, the value of the ultimate tensile force at rupture was increased by 4.5 N (108% of control, P = .006) when eccentric training was performed. An intragroup analysis revealed that eccentric training significantly improved the ultimate force values for the PRP group. Proteomic analysis revealed that eccentric training led to an increase in abundance of several cytoskeletal proteins in the PF group, while a decrease in abundance of enzymes of the glycolytic pathway occurred in the PRP treated groups, indicating that this treatment might redirect the exercise-driven metabolic plasticity of the tendon. CONCLUSION: Eccentric training altered the metabolic plasticity of tendon and led to an improvement of injured tendon resistance regardless of the treatment injected (PF or PRP). CLINICAL RELEVANCE:This study demonstrates the necessity of eccentric rehabilitation and training in cases of tendon lesion regardless of the treatment carried out. [less ▲]

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See detailPRTEE et épicondylite
Janssen, Arnaud; Kaux, Jean-François ULiege

in Kinésithérapie du Sport Information (2017), (2ème trimestre 2017), 4-7

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See detailMartian mesospheric cloud observations by IUVS on MAVEN: Thermal tides coupled to the upper atmosphere
Stevens; Siskind; Evans et al

in Geophysical Research Letters (2017), 44

The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are ... [more ▼]

The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are uniquely obtained at early morning local times, whichcomplement previous observations obtained primarily later in the diurnal cycle. Differences in thegeographic distribution of the clouds from IUVS observations indicate that the local time is crucial for theinterpretation of mesospheric cloud formation. We also report concurrent observations of upperatmospheric scale heights near 170 km altitude, which are diagnostic of temperature. These observationssuggest that the dynamics enabling the formation of mesospheric clouds propagate all the way to theupper atmosphere. [less ▲]

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See detailTargeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides
Delierneux, Céline ULiege; Donis, Nathalie ULiege; servais, laurence et al

in Journal of Thrombosis and Haemostasis (2017), 15(5), 983-997

Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment ... [more ▼]

Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. Objective: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies. Methods: In vitro analyses were performed on human and mouse platelets, and on cell lines expressing platelet ITAM receptors. CpG ODN platelet activating effects were evaluated in a mouse model of thrombosis. Results: We demonstrated platelet uptake of CpG ODNs, resulting in platelet activation and aggregation. The C-type lectin-like receptor 2 (CLEC-2) expressed in DT40 cells bound CpG ODNs. CpG ODN uptake did not occur in CLEC-2-deficient mouse platelets. Inhibition of human CLEC-2 with a blocking antibody inhibited CpG ODN-induced platelet aggregation. CpG ODNs caused CLEC-2 dimerization, and provoked its internalization. They induced dense granule release before the onset of aggregation. Accordingly, pretreating platelets with apyrase, or inhibiting P2Y12 with cangrelor or clopidogrel prevented CpG ODN platelet activating effect. In vivo, intravenously injected CpG ODN interacted with platelets adhered to mouse injured endothelium, and promoted thrombus growth, which was inhibited by CLEC-2 deficiency or by clopidogrel. Conclusions: CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis and might be targeted to prevent adverse events in patients at risk. [less ▲]

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See detailA Highly Durable RNAi Therapeutic Inhibitor of PCSK9
LANCELLOTTI, Patrizio ULiege; Oury, Cécile ULiege

in New England Journal of Medicine (2017), 376

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See detailAdvanced method optimization for volatile aroma profiling of beer using two-dimensional gas chromatography time-of-flight mass spectrometry
Stefanuto, Pierre-Hugues ULiege; Perrault, Katelynn ULiege; Dubois, Lena ULiege et al

in Journal of Chromatography. A (2017)

The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two ... [more ▼]

The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) for highlighting subtle differences between highly complex mixtures of VOCs. Headspace solid-phase microextraction (HS-SPME), multiple (and classical) stir bar sorptive extraction (mSBSE), static headspace (SHS), and dynamic headspace (DHS) were compared for the extraction of a set of 21 representative flavor compounds of beer aroma. A Box-Behnken surface response methodology experimental design optimization (DOE) was used for convex hull calculation (Delaunay’s triangulation algorithms) of peak dispersion in the chromatographic space. The predicted value of 0.5 for the ratio between the convex hull and the available space was 10% higher than the experimental value, demonstrating the usefulness of the approach to improve optimization of the GC × GC separation. Chemical variations amongst aligned chromatograms were studied by means of Fisher Ratio (FR) determination and F‐distribution threshold filtration at different significance levels (α = 0.05 and 0.01) and based on z‐score normalized area for data reduction. Statistically significant compounds were highlighted following principal component analysis (PCA) and hierarchical cluster analysis (HCA). The dendrogram structure not only provided clear visual information about similarities between products but also permitted direct identification of the chemicals and their relative weight in clustering. The effective coupling of DHS-TD-GC × GC-TOFMS with PCA and HCA was able to highlight the differences and common typical VOC patterns among 24 samples of different Trappist and selected Canadian craft beers. [less ▲]

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See detailRégimes matrimoniaux et effets patrimoniaux des partenariats enregistrés en Europe. Propos introductifs
Wautelet, Patrick ULiege

in Droit de la famille (2017), 22(5), 10-13

Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des ... [more ▼]

Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des questions ouvertes qu'ils posent [less ▲]

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See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

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See detailLa déficience en hormone lutéinisante: ses conséquences sur la reproduction
VALDES SOCIN, Hernan Gonzalo ULiege; potorac, iulia; LIBIOULLE, Cécile ULiege et al

in Urologic (2017), 13(1), 18-23

En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables ... [more ▼]

En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables à la virilisation et à la féminisation) ainsi que la gamétogenèse (spermatogenèse chez l’homme et folliculogenèse chez la femme). La sécrétion des gonadotrophines hypophysaires est à son tour stimulée par quelque 1.500 neurones hypothalamiques à GnRH (gonadotrophin releasing hormone) et inhibée par la GnIH (gonadotrophin nhibitory hormone), récemment identifiée (1). En amont de la GnRH, un ensemble de neuropeptides hypothalamiques tels que les kisspeptines, la neuroquinine B, la dinorphine, la leptine, etc., modulent sa sécrétion (Figure 1). Ces neuropeptides intègrent les différents signaux internes et de l’environnement, nécessaires à la puberté et, par la suite, à la reproduction. En corollaire de ces données physiologiques, les patients porteurs de mutations invalidant les gènes de la GnRH, des neuropeptides décrits et de leurs récepteurs souffrent d’un hypogonadisme hypogonadotrope. Ces patients présentent un déficit plus ou moins sévère de la sécrétion combinée de LH et de FSH (2, 3). Il a fallu attendre des observations rares, telles que des mutations de la sous-unité beta (β) de l’hormone lutéinisante, pour comprendre la contribution spécifique et isolée de cette hormone à la reproduction. Dans cet article, nous synthétisons les données historiques et récentes sur la déficience en hormone lutéinisante et ses conséquences sur la reproduction. [less ▲]

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See detailFinite element model reduction for space thermal analysis
Jacques, Lionel ULiege; Béchet, Eric ULiege; Kerschen, Gaëtan ULiege

in Finite Elements in Analysis and Design (2017), 127

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]

To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]

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See detailTowards laser control of open quantum systems: memeory effects
Puthumpally-Joseph, Raijumon; Atabek, Osman; Mangaud, Etienne et al

in Molecular Physics (2017)

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See detailThe internet as a source of information used by women after childbirth to meet their need for information: A web-based survey.
Slomian, Justine ULiege; Bruyère, Olivier ULiege; Reginster, Jean-Yves ULiege et al

in Midwifery (2017), 48

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to ... [more ▼]

OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to meet their need of information; (c) to describe how the respondents evaluate the reliability of the information found; (d) to understand how the information found on the Internet affects women's decision-making; and (e) to appreciate how health professionals react to the information found by the women. DESIGN: this study used a large web-based survey that was widely broadcasted on various websites and social networks. SETTING AND PARTICIPANTS: belgian women who had a child under 2 years old and who agreed to participate were included in the study. FINDINGS: 349 questionnaires were valid for analyses. After childbirth, 90.5% of women admitted to using the Internet to seek information about themselves or about their baby, regardless of socioeconomic status or age. There were various reasons for seeking information on the Internet, but the most frequent reason the women expressed was to find information 'on their own' (88.1%). The most searched for topic was breastfeeding. The women believed that the information was quite useful (82.7%) but they assigned an average score of 5.3 out of 10 for the quality of the information they found on the Internet. Approximately 80% of the women felt that the Internet helped them control a decision that they made 'a little', 'often' or 'very often'. Professionals are not always willing to talk about information found on the Internet with mothers. Therefore, many women believed that health professionals should suggest reliable Internet websites for new mothers. CONCLUSIONS: the integration of the Internet and new technologies could be a useful tool during postpartum management. [less ▲]

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See detailNonribosomal peptides and polyketides of Burkholderia: new compounds potentially implicated in biocontrol and pharmaceuticals
Esmaeel, Q.; Pupin, M.; Jacques, Philippe ULiege et al

in Environmental Science and Pollution Research (2017)

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See detailExperimental and Numerical Study of Mini-UAV Propeller Performance in Oblique Flow
Theys, Bart; Dimitriadis, Grigorios ULiege; Hendrick, Patrick et al

in Journal of Aircraft (2017), 54(3), 1076-1084

This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow ... [more ▼]

This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow. Blade Element Momentum Theory (BEMT), Vortex Lattice Method (VLM) and momentum theory for oblique flow are used to predict propeller performance. For validation, the predictions for a commonly used propeller for VTOL MAVs are compared to a set of wind tunnel experiments. Both BEMT and VLM succeed in predicting correct trends of the forces and moments acting upon the propeller shaft, although accuracy decreases significantly in oblique flow. For the dataset analysed here, combining the available data of the propeller in purely axial flow with momentum theory for oblique flow and applying a correction factor for the wake skew angle results in more accurate performance estimates at all elevation angles. [less ▲]

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See detailUltrasonic roll bite measurements in cold rolling: Contact length and strip thickness
Carretta, Yves; Hunter, Andrew; Boman, Romain ULiege et al

in Proceedings of the Institution of Mechanical Engineers - Part J - Journal of Engineering Tribology (2017)

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]

In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, online process measurements are usually carried out; such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring strip thickness variations as well as roll bite length in situ and in real time. The sensor emits ultrasonic pulses that reflect from the interface between the roll and the strip. Both the time-of-flight of the pulses and the reflection coefficient (the ratio of the amplitude of the reflected signal to that of the incident signal) are recorded. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under several lubrication conditions. Strip thickness variation and roll-bite length obtained from the experimental data agree well with numerical results computed with a cold rolling model in the mixed lubrication regime. [less ▲]

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See detailExperimental passive flutter suppression using a linear tuned vibration absorber
Verstraelen, Edouard ULiege; Habib, Giuseppe ULiege; Kerschen, Gaëtan ULiege et al

in AIAA Journal (2017), 55(5), 1707-1722

The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be ... [more ▼]

The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be increased flexibility, which in turn can lead to un- favourable aeroelastic phenomena involving large amplitude oscillations and non- linear effects such as geometric hardening and stall flutter. Vibration mitigation is one of the approaches currently under study for avoiding these phenomena. In the present work, passive vibration mitigation is applied to a nonlinear experimental aeroelastic system by means of a linear tuned vibration absorber. The aeroelastic apparatus is a pitch and flap wing that features a continuously hardening restoring torque in pitch and a linear restoring torque in flap. Extensive analysis of the sys- tem with and without absorber at pre-critical and post-critical airspeeds showed an improvement in flutter speed of around 36%, a suppression of a jump due to stall flutter, and a reduction in LCO amplitude. Mathematical modelling of the exper- imental system is used to demonstrate that optimal flutter delay is achieved when two of the system modes flutter at the same flight condition. Nevertheless, even this optimal absorber quickly loses effectiveness as it is detuned. The wind tunnel mea- surements showed that the tested absorbers were much slower to lose effectiveness than those of the mathematical predictions. [less ▲]

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See detailInsights into a million-year-scale Rhenohercynian carbonate platform evolution through a multi-disciplinary approach: example of a GIvetian carbonate record from Belgium
Pas, Damien ULiege; Da Silva, Anne-Christine ULiege; Devleeschouwer, Xavier et al

in Geological Magazine (2017), 154(4), 707-739

In this paper we formulate answers to three important questions related to Givetian carbonate records and their use for reconstructing million-year past palaeoenvironmental changes. First, we provide ... [more ▼]

In this paper we formulate answers to three important questions related to Givetian carbonate records and their use for reconstructing million-year past palaeoenvironmental changes. First, we provide detailed illustrations of the fascinating diversity that shaped a significant shallow reefal platform during the early- to late-Givetian in the Rhenohercynian Ocean; secondly we improve the sedimentological model of the extensive Givetian carbonate platform in the Dinant Basin and thirdly we evaluate the application of magnetic susceptibility (MS) as a tool for long-term trend correlations and palaeoenvironmental reconstructions. These goals are reached by making sedimentological, geophysical and geochemical study of the La Thure section. Through the early-late Givetian interval we discerned eighteen microfacies ranging from a homoclinal ramp to a discontinuously rimmed shelf and then a drowning shelf. The comparison of these sedimentological results with those published in the south of the Dinant Syncline allowed us to provide an up to date model of the vertical and lateral environmental development for one of the largest Givetian carbonate platforms in Europe. This comparison also increased the knowledge on the facies belts distribution into the Dinant Basin and allowed us to highlight the Taghanic Event. Palaeo-redox proxies reveal a substantial change in the oxygenation level, from oxygen-depleted to more oxic condition, between middle and late Givetian. We demonstrated the relationship between variation in MS values and proxies for siliciclastic input (such as Si, Al). The La Thure is considered as a key section for the understanding of internal shelf settings bordering Laurussia’s south-eastern margin. [less ▲]

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See detailIntergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)
Brotcorne, Fany ULiege; Giraud, Gwennan; Gunst, Noelle et al

in Primates : Journal of Primatology (2017)

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]

Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]

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See detailContinental Climate Gradients in North America and Western Eurasia before and after the Closure of the Central American Seaway
Utescher, Torsten; Dreist, Andreas; Henrot, Alexandra-Jane ULiege et al

in Earth and Planetary Science Letters (2017), 472

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See detailLa Cour de cassation face à sa propre faute (obs. sous C.C. 2017/22)
Bouhon, Frédéric ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), 2017/22

Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les ... [more ▼]

Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les dommages engendrés par la faute du juge. Il est question du cas particulier où un justiciable demande au juge du fond de condamner l’État belge à réparer un dommage causé par une faute qu’aurait commise la Cour de cassation. Plus précisément, il apporte une réponse – positive – à la question de savoir si cette haute juridiction peut, dans l’hypothèse où un pourvoi est formé contre la décision du juge du fond, intervenir dans une affaire qui concerne une faute qu’elle a prétendument commise, en influençant, le cas échéant, l’interprétation de la notion de faute appliquée à son propre acte. [less ▲]

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See detailStudy of the correlation between fengycin promoter expression and its production by Bacillus subtilis under different culture conditions and the impact on surfactin production
Mejri, S.; Siah, A.; Coutte, F. et al

in Environmental Science and Pollution Research (2017)

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See detailCalibration and testing of wide-field UV instruments
Frey, Harald; Mende, Stephen; Loicq, Jerôme ULiege et al

in Journal of Geophysical Research. Space Physics (2017), 122

As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations ... [more ▼]

As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination. [less ▲]

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See detailSteel construction - design and research - Special issue associated to the TC11 workshop
Demonceau, Jean-François ULiege; Graziano, Leoni; Couchman, Graham et al

in Steel Construction (2017), 10

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See detailTesting a general approach to assess the degree of disturbance in tropical forests
Sellan, Giacomo; Simini, Filippo; Maritan, Amos et al

in Journal of Vegetation Science (2017), 28(3), 459668

Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of ... [more ▼]

Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of disturbance? Location: Reserve of Yangambi, northeast region of the Democratic Republic of Congo. Methods: We applied an allometricmodel based on the assumption that a vir- tually undisturbed forest uses all available resources. In this condition, the forest structure (e.g. the tree size distribution) is theoretically predictable fromthe scal- ing of the tree crown with tree height at an individual level. The degree of dis- turbance can be assessed through comparing the slopes of the tree size distribution curves in the observed and predicted conditions. We tested this tool in forest stands subjected to different degrees of disturbance. We inventoried trees >1.3 m in height by measuring the DBH in three plots of 1 ha each, and measured tree height, crownradius and crownlength in a sub-sample of trees. Results: All tree species, independently of the site, shared the same exponents of allometric relationships: tree height vs tree diameter, crown radius vs tree height, crown length vs tree height and consequently crown volume vs tree height, suggesting that similar trajectories of biomass allocation have evolved irrespective of species. The observed tree size distributions appeared to be power laws (excluding the finite size effect) and, as predicted, the slope was steeper in the less disturbed forest (?2.34) compared to the most disturbed (?1.99). The difference in the slope compared to the theoretical fully functional forest (?2.65) represents the metric for assessing the degree of disturbance. Conclusions: We developed a simple tool for operationalizing the concept of ‘disturbance’ in tropical forests. This approach is species-independent, needs minimal theoretical assumptions, the measurement of only a few structural traits and requires a low investment in equipment, time and computer skills. Its simple implementation opens new perspectives for effectively addressing initiatives of forest protection and/or restoration. [less ▲]

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See detailPowers, abilities and skills in early modern philosophy
Boccaccini, Federico ULiege; Marmodoro, Anna

in British Journal for the History of Philosophy (2017), 25(3), 1-8

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See detailOrigin of the counterintuitive dynamic charge in the transition metal dichalcogenides
Pike, Nicholas ULiege; Van Troeye, Benoit; Dewandre, Antoine ULiege et al

in Physical Review B (2017), 95

Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we ... [more ▼]

Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we investigate their static and dynamic charges. The dynamic charge of the transition metal dichalcogenides with trigonal symmetry are anomalously large, while in their hexagonally symmetric counterparts, we even observe a counterintuitive sign, i.e., the transition metal takes a negative charge, opposite to its static charge. This phenomenon, so far never remarked on or analyzed, is understood by investigating the perturbative response of the system and by investigating the hybridization of the molecular orbitals near the Fermi level. Furthermore, a link is established between the sign of the Born effective charge and the process of π backbonding from organic chemistry. Experiments are proposed to verify the calculated sign of the dynamical charge in these materials. Employing a high-throughput search we also identify other materials that present counterintuitive dynamic charges. [less ▲]

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See detailSustainability Accounting and Control for Smart City - Special Issue - Call for Papers
Crutzen, Nathalie ULiege; Van Bockhaven, Jonas; Schaltegger, Stefan et al

in sustainability accounting, management and policy journal (2017)

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See detailDiscovery and pharmacological characterization of succinate receptor (SUCNR1/GPR91) agonists
Geubelle, Pierre ULiege; Gilissen, Julie; Dilly, Sebastien et al

in British Journal of Pharmacology (2017), 174(9), 796-808

Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho ... [more ▼]

Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of SUCNR1 has remained elusive because no pharmacological tools were available. We report on the discovery of the first family of synthetic potent agonists. Experimental Approach We screened a library of succinate analogues and analysed their activity on SUCNR1. In addition, we modelled a pharmacophore and a binding site for the receptor. New agonists were identified based on the information provided by these two approaches. Their activity was studied in various bioassays, including measurement of cAMP levels, [Ca2+]i mobilisation, TGF-α shedding and recruitment of arrestin 3. The in vivo impact of SUCNR1 activation by these new agonists was evaluated on rat blood pressure. Key Results We identified cis-epoxysuccinic acid and cis-1,2-cyclopropanedicarboxylic acid as agonists with an efficacy similar to the one of succinic acid. Interestingly, cis-epoxysuccinic acid was characterized by a 10 to 20 fold higher potency than succinate on the receptor. For example, cis-epoxysuccinic acid reduced cAMP levels with a pEC50 = 5.57 ± 0.02 (EC50 = 2.7 μM) as compared to succinate pEC50 = 4.54 ± 0.08 (EC50 = 29 μM). The rank order of potency of the three agonists was the same in all bioassays tested. In vivo, cis-epoxysuccinic and cis-1,2-cyclopropanedicarboxylic acid increased rat blood pressure to the same extent as succinate did. Conclusions and Implications We provide new agonist tools for SUCNR1 that should facilitate further research on this understudied receptor. [less ▲]

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See detailTwo-qubit entangling gates between distant atomic qubits in a lattice
Cesa, Alexandre ULiege; Martin, John ULiege

in Physical Review A (2017), 95

Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two ... [more ▼]

Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two-qubit conditional gates between nearest-neighbor qubits in the array can be implemented by exploiting the Rydberg blockade mechanism, as was shown by D. Jaksch et al. [Phys. Rev. Lett. 85, 2208 (2000)]. However, the energy shift due to dipole-dipole interactions causing the blockade falls off rapidly with the interatomic distance, and protocols based on direct Rydberg blockade typically fail to operate between atoms separated by more than one lattice site. In this work, we propose an extension of the protocol of Jaksch et al. for controlled-Z and controlled-NOT gates which works in the general case where the qubits are not nearest neighbors in the array. Our proposal relies on the Rydberg excitation hopping along a chain of ancilla noncoding atoms connecting the qubits on which the gate is to be applied. The dependence of the gate fidelity on the number of ancilla atoms, the blockade strength, and the decay rates of the Rydberg states is investigated. A comparison between our implementation of a distant controlled-NOT gate and one based on a sequence of nearest-neighbor two-qubit gates is also provided. [less ▲]

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See detailIsotopic half-life and enrichment factor in two species of European freshwater fish larvae: an experimental approach
Latli, Adrien; Sturaro, Nicolas ULiege; Dujardin, Nelson et al

in Rapid Communications in Mass Spectrometry (2017), 31(8), 685-692

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue ... [more ▼]

RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in two freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation. After yolk sac resorption, larvae were fed for 5 weeks with prey similar to their natural diet (Artemia nauplii) up to the isotopic equilibrium followed by Chironomid larvae. Stable isotope measurements were carried out using a continuous flow isotope ratio mass spectrometer coupled to an elemental analyser. RESULTS: Changes in isotopic composition strongly followed the predictions of exponential growth and time-dependent models. The isotopic HL varied between 8.2 and 12.6 days and the TEF of nitrogen and carbon ranged from 1.7 to 2.1‰ and from –0.9 to 1.2 ‰, respectively. The incorporation of dietary 13C was due more to the production of new tissue (between 56 and 79%) than to the metabolic process. Chub allocated more energy to growth than roach and the Chironomidae diet contributed more to the consumers’ growth than the Artemia diet. CONCLUSIONS: Metabolic rates seemed lower for chub than for roach, especially when they were fed with Chironomidae. A Chironomidae-based diet would be more profitable to chub, and the high associated growth rate could increase the development of the fish larvae. The HL and TEF were in the range of those reported in the literature. These results will be helpful for field-based studies, because they can help to increase the accuracy of models. [less ▲]

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See detailEffect of growth rate on the physical and mechanical properties of Douglas-fir in Western Europe
Polet, Caroline; Henin, Jean-Marc; Hebert, Jacques ULiege et al

in Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2017), 47

To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens ... [more ▼]

To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens. These were collected from trees cut in 11 even-aged stands (6 trees/stand) located in Wallonia (Southern Belgium). Stands were 40 to 69 years old and the mean tree girth was ca. 150 cm. The mean ring width of the 66 trees ranged from 3 to more than 7 mm. Statistical analysis evidenced significant but weak effects of ring width. So, mean ring width and cambial age of the specimens considered jointly only explain 28 to 40% of the variability of the properties studied. From a purely technological standpoint, maintaining mean ring width under 4 mm/year in juvenile wood and 6 mm/year in mature wood should allow all potential uses of Douglas-fir wood. Our results and the literature demonstrate, however, the importance of genetic selection as a complement of silvicultural measures to improve or guarantee the technological properties of Douglas-fir wood. [less ▲]

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See detailPhotosensitive polydimethylsiloxane networks for adjustable-patterned films
Jellali, Rachid; Alexandre, Michaël; Jérôme, Christine ULiege

in Polymer Chemistry (2017), 8(16), 2499-2508

Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV ... [more ▼]

Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV light having a wavelength of above 300 nm, multifunctional coumarin-PDMSs are transformed into covalent networks via [2 + 2] photocycloaddition of two coumarin moieties forming a cyclobutane ring. Taking advantage of the possible localized irradiation through a photomask, a novel concept to generate patterned PDMS films with various surface topologies was demonstrated. This concept is based on the combination of a low molar mass difunctional PDMS with a multifunctional PDMS of a high molar mass forming a photoreversible network allowing osmotic diffusion of a linear PDMS-coumarin of low mole- cular weight in a loosely crosslinked network. Advantageously, illumination by a light source at 254 nm induces the photocleavage of the cyclobutane cross-links offering some photo-induced reversibility to the PDMS network. These novel photo-responsive networks are interesting for several applications, in photo-adaptable biomedical implants (particularly photo-adjustable intra-ocular lenses), photo-tuneable patterned microsystems (e.g. for microfluidics) and photo-switchable controlled release systems. [less ▲]

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See detailX-LAG: How did they grow so tall?
BECKERS, Albert ULiege; Rostomyan, Liliya ULiege; Potorac, Iulia ULiege et al

in Annales d'Endocrinologie (2017)

X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset ... [more ▼]

X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very advanced age-specific height Z-scores. If not adequately treated in childhood, this condition results in extreme final adult height. XLAG has a clinical course that is highly similar to some of the tallest people with gigantism in history. « X-linked acrogigantism » (XLAG) est un syndrome pédiatrique récemment décrit, lié à des microduplications du chromosome Xq26.3, englobant le gène GPR101, responsable de l’affection. Les patients XLAG présentent un phénotype remarquablement distinct des autres cas de gigantisme hypophysaire. Dans tous les cas décrits, la maladie s’exprime avant 5 ans soit beaucoup plus tôt que dans les autres formes. Les patients ont habituellement un gros adénome ou une hyperplasie mixte pour la GH et la prolactine et des taux très élevés de GH/IGF1 et prolactine. En raison de son début très précoce, l’hypersécrétion importante de GH peut conduire à un gigantisme extrêmement sévère avec un Z-score très important pour l’âge. Si cette condition n’est pas traitée pendant l’enfance, elle peut conduire à une taille finale extrême. XLAG montre une évolution clinique similaire à celle observée chez les géants les plus grands de l’histoire. [less ▲]

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See detailGlobal approach for the validation of an in-line Raman spectroscopic method to determine the API content in real-time during a hot-melt extrusion process
Netchacovitch, Lauranne ULiege; Thiry, Justine ULiege; De Bleye, Charlotte ULiege et al

in Talanta (2017), 171

Since the Food and Drug Administration (FDA) published a guidance based on the Process Analytical Technology (PAT) approach, real-time analyses during manufacturing processes are in real expansion. In ... [more ▼]

Since the Food and Drug Administration (FDA) published a guidance based on the Process Analytical Technology (PAT) approach, real-time analyses during manufacturing processes are in real expansion. In this study, in-line Raman spectroscopic analyses were performed during a Hot-Melt Extrusion (HME) process to determine the Active Pharmaceutical Ingredient (API) content in real-time. The method was validated based on a univariate and a multivariate approach and the analytical performances of the obtained models were compared. Moreover, on one hand, in-line data were correlated with the real API concentration present in the sample quantified by a previously validated off-line confocal Raman microspectroscopic method. On the other hand, in-line data were also treated in function of the concentration based on the weighing of the components in the prepared mixture. The importance of developing quantitative methods based on the use of a reference method was thus highlighted. The method was validated according to the total error approach fixing the acceptance limits at ± 15% and the α risk at ± 5%. This method reaches the requirements of the European Pharmacopeia norms for the uniformity of content of single-dose preparations. The validation proves that future results will be in the acceptance limits with a previously defined probability. Finally, the in-line validated method was compared with the off-line one to demonstrate its ability to be used in routine analyses. [less ▲]

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See detailPressure flaking to serrate bifacial points for the hunt during the MIS5 at Sibudu Cave (South Africa)
Rots, Veerle ULiege; Lentfer, Carol ULiege; Schmid, Viola C. et al

in PLoS ONE (2017), 12(4), 0175151

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See detailSize and shape variations of the bony components of sperm whale cochleae
Schnitzler, Joseph ULiege; Frederich, Bruno ULiege; Früchtnicht, Sven et al

in Scientific Reports (2017), 7

Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of ... [more ▼]

Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of Schleswig Holstein. The present study aims to explore the morphological variation of the primary sensory organ of sperm whales, the left and right auditory system, using high-resolution computerised tomography imaging. We performed a quantitative analysis of size and shape of cochleae using landmark-based geometric morphometrics to reveal inter-individual anatomical variations. A hierarchical cluster analysis based on thirty-one external morphometric characters classified these 12 individuals in two stranding clusters. A relative amount of shape variation could be attributable to geographical differences among stranding locations and clusters. Our geometric data allowed the discrimination of distinct bachelor schools among sperm whales that stranded on German coasts. We argue that the cochleae are individually shaped, varying greatly in dimensions and that the intra-specific variation observed in the morphology of the cochleae may partially reflect their affiliation to their bachelor school. There are increasing concerns about the impact of noise on cetaceans and describing the auditory periphery of odontocetes is a key conservation issue to further assess the effect of noise pollution. [less ▲]

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See detailResolved astrometric orbits of ten O-type binaries
Le Bouquin, J.-B.; Sana, H.; Gosset, Eric ULiege et al

in Astronomy and Astrophysics (2017), 601

Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2 ... [more ▼]

Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2). We follow-up ten O+O binaries with AMBER, PIONIER and GRAVITY at the VLTI. Here, we report about 130 astrometric observations over the last 7 years. We combine this dataset with distance estimates to compute the total mass of the systems. We also compute preliminary individual component masses for the five systems with available SB2 radial velocities. Nine over the ten binaries have their three dimensional orbit well constrained. Four of them are known colliding wind, non-thermal radio emitters, and thus constitute valuable targets for future high angular resolution radio imaging. Two binaries break the correlation between period and eccentricity tentatively observed in previous studies. It suggests either that massive star formation produce a wide range of systems, or that several binary formation mechanisms are at play. Finally, we found that the use of existing SB2 radial velocity amplitudes can lead to unrealistic masses and distances. If not understood, the biases in radial velocity amplitudes will represent an intrinsic limitation for estimating dynamical masses from SB2+interferometry or SB2+Gaia. Nevertheless, our results can be combined with future Gaia astrometry to measure the dynamical masses and distances of the individual components with an accuracy of 5 to 15\%, completely independently of the radial velocities. [less ▲]

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See detailReconstructions of the 1900–2015 Greenland ice sheet surface mass balance using the regional climate MAR model
Fettweis, Xavier ULiege; Box, Jason; Agosta, Cécile ULiege et al

in Cryosphere (The) (2017), 11

With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional ... [more ▼]

With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional; version 3.5.2) model with the ERA-Interim (ECMWF Interim Re-Analysis; 1979–2015), ERA-40 (1958–2001), NCEP–NCARv1 (National Centers for Environmental Prediction–National Center for Atmospheric Research Reanalysis version 1; 1948–2015), NCEP–NCARv2 (1979–2015), JRA-55 (Japanese 55-year Reanalysis; 1958–2014), 20CRv2(c) (Twentieth Century Reanalysis version 2; 1900–2014) and ERA-20C (1900–2010) reanalyses. While all these forcing products are reanalyses that are assumed to represent the same climate, they produce significant differences in the MAR-simulated SMB over their common period. A temperature adjustment of +1 °C (respectively −1 °C) was, for example, needed at the MAR boundaries with ERA-20C (20CRv2) reanalysis, given that ERA-20C (20CRv2) is ∼ 1 °C colder (warmer) than ERA-Interim over Greenland during the period 1980–2010. Comparisons with daily PROMICE (Programme for Monitoring of the Greenland Ice Sheet) near-surface observations support these adjustments. Comparisons with SMB measurements, ice cores and satellite-derived melt extent reveal the most accurate forcing datasets for the simulation of the GrIS SMB to be ERA-Interim and NCEP–NCARv1. However, some biases remain in MAR, suggesting that some improvements are still needed in its cloudiness and radiative schemes as well as in the representation of the bare ice albedo. Results from all MAR simulations indicate that (i) the period 1961–1990, commonly chosen as a stable reference period for Greenland SMB and ice dynamics, is actually a period of anomalously positive SMB (∼ +40 Gt yr−1) compared to 1900–2010; (ii) SMB has decreased significantly after this reference period due to increasing and unprecedented melt reaching the highest rates in the 120-year common period; (iii) before 1960, both ERA-20C and 20CRv2-forced MAR simulations suggest a significant precipitation increase over 1900–1950, but this increase could be the result of an artefact in the reanalyses that are not well-enough constrained by observations during this period and (iv) since the 1980s, snowfall is quite stable after having reached a maximum in the 1970s. These MAR-based SMB and accumulation reconstructions are, however, quite similar to those from Box (2013) after 1930 and confirm that SMB was quite stable from the 1940s to the 1990s. Finally, only the ERA-20C-forced simulation suggests that SMB during the 1920–1930 warm period over Greenland was comparable to the SMB of the 2000s, due to both higher melt and lower precipitation than normal. [less ▲]

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See detailThe growth and meat quality of H'mong chicken raised by industrial farming
Nguyen Van Duy, ULiege; Vu Dinh, Ton; Nguyen Thi, Phuong

in Journal of Sciences of Agriculture Vietnams (2017), 15(4), 438-445

This study was carried out at the experimental farm of Vietnam National University of Agriculture from January to December, 2016 on H’mong chickens that were raised by industrial farming. H’mong chickens ... [more ▼]

This study was carried out at the experimental farm of Vietnam National University of Agriculture from January to December, 2016 on H’mong chickens that were raised by industrial farming. H’mong chickens were raised in three lots in order to observe the survival rate, growth capacity, FCR and quality of meat. The results show that Hmong chicken adapted well with industrial farming method, which supposedly contributed to the improvement in survival rate of chickens (94,1%) compared to traditional free-range farming method.. H'mong chickens have low weight and considerable growth speed. Average daily gain of H’mong chickens was increasing gradually from one to ten weeks of age and then decreasing. From one to 12 weeks, H'mong chickens consumes averagely 24.81 grams of feed per day and Feed Conversation Rate was 3.1 kg of feed/kg live body weight. Twelve week-old roosters and hens achieved body weight at 1206,7g and 1026,7g in respectively. H'mong chicken is a dual-purpose breed, producing an amount of thigh meat 1.3 times greater than breast meat. The proportion of iron in Hmong chicken meat is higher than that in other domestic chicken breeds and there are eight unsubstituted amino acids in the meat. Key works: H’mong chickens, industrial farming. [less ▲]

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See detailComment on “Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene”
VALDES SOCIN, Hernan Gonzalo ULiege; Daly, Adrian ULiege; BECKERS, Albert ULiege

in Korean Journal of Internal Medicine (The) (2017), 32(3), 566-567

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See detailOrganometallic-mediated radical polymerization of 'less activated monomers': fundamentals, challenges and opportunities
Debuigne, Antoine ULiege; Jérôme, Christine ULiege; Detrembleur, Christophe ULiege

in Polymer (2017), 115

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the ... [more ▼]

Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the double bond of these monomers. This Feature Article summarizes substantial progress in the organometallic-mediated radical polymerization (OMRP) of this important class of monomers including vinyl esters, olefins, vinyl chloride, vinyl amides, or ionic-liquid vinyl monomers. It aims to provide a clear and comprehensive account of the fundamentals and challenges in the OMRP of LAMs as well as an overview of the resulting macromolecular engineering opportunities. The input of photochemistry, environmentally friendly solvents or flow reactors in OMRP is also presented. Finally, it emphasizes how some well-defined LAMs-based materials contributed to the development of specific applications notably in the fields of biomedicine or energy. [less ▲]

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See detailGroup B Streptococcus and perinatal mortality
COOLS, Piet; MELIN, Pierrette ULiege

in Research in Microbiology (2017), 17

The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections ... [more ▼]

The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections. Here we discuss the role of Streptococcus agalactiae (group B Streptococcus, GBS) in neonatal disease and stillbirth. [less ▲]

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See detailBayesian estimation of genetic parameters for individual feed conversion and body weight gain in meat quail
DA COSTA CAETANO, GIOVANI; REIS MOTA, Rodrigo ULiege; ALVES DA SILVA, DELVAN et al

in Livestock Science (2017), 200

We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail ... [more ▼]

We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail breeding programs. Data included 379 records from two different genetic lines (188 quails from UFV1 and 191 from UFV2). The following traits were evaluated:individual feed conversion from21to28(FC21–28)andfrom28to35daysofage (FC28–35); body weight gain from 1 to 21 (BWG1–21), 21–28 (BWG21–28), 28–35 (BWG28–35) and from 1 to 35 (BWG1–35, full period) days of age. Genetic parameters (heritabilities and genetic correlations) were estimated through multi-trait models via Bayesian inference. For UFV1 line, genetic correlations estimates (with respective credible intervals) between BWG1–21 and BWG1–35, BWG21–28 and BWG1–35, BWG28–35 and BWG1–35, FC21–28 and FC28–35, FC 21–28 and BWG1–35, and FC28–35 and BWG1–35 were 0.62 0.15–0.90), 0.81 0.60–0.94), 0.69 0.35–0.88), 0.06 (−050 to 0.60), −0.87 (−0.97 to −0.63) and −0.51 (−0.84 to −0.01), respectively; and for UFV2 line, these estimates were 0.33 (−0.05 to 0.63), 0.79 0.59–0.92), 0.88 0.73–0.96), 0.35 (−0.30 to 0.78), −0.56 (−0.85 to −0.09) and −0.76 (−0.93 to −0.41), respectively. Additionally, for the UFV1 line heritability estimates for BWG21–28 and FC21–28 were 0.69 0.40–0.86) and 0.55 0.31–0.74), respectively; while for UFV2 line the heritabilities for BWG28–35 and FC28–35 were 0.68 0.47–0.83) and 0.37 0.17–0.63). Based on these results, we recommend as target traits BWG21–28 and FC21–28 for UFV1 line; and BWG28–35 for UFV2 line. Selecting for these indicated traits, we expect to reduce breeding program costs related mainly to feeding of nonselected animals and labor with phenotyping. [less ▲]

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See detailVortex Lattice simulations of attached and separated flows around flapping wings
Lambert, Thomas ULiege; Abdul Razak, Norizham; Dimitriadis, Grigorios ULiege

in Aerospace (2017), 4(2), 22

Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads ... [more ▼]

Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads acting on flapping wings are of interest for designing such aircraft and optimising thrust production. In this work, the unsteady Vortex Lattice method is used in conjunction with three load estimation techniques in order to predict the aerodynamic lift and drag time histories produced by flapping rectangular wings. The load estimation approaches are the Katz, Joukowski and simplified Leishman-Beddoes techniques. The simulations' predictions are compared to experimental measurements from a flapping and pitching wing presented by Razak and Dimitriadis [1]. Three types of kinematics are investigated, pitch-leading, pure flapping and pitch lagging. It is found that pitch-leading tests can be simulated quite accurately using either the Katz or Joukowski approaches as no measurable flow separation occurs. For the pure flapping tests, the Katz and Joukowski techniques are accurate as long as the static pitch angle is greater than zero. For zero or negative static pitch angles these methods underestimate the amplitude of the drag. The Leishman-Beddoes approach yields better drag amplitudes but can introduce a constant negative drag offset. Finally, for the pitch-lagging tests the Leishman-Beddoes technique is again more representative of the experimental results, as long as flow separation is not too extensive. Considering the complexity of the phenomena involved, in the vast majority of cases the lift time history is predicted with reasonable accuracy. The drag (or thrust) time history is more challenging. [less ▲]

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See detailThe recent warming trend in North Greenland
Orsi, A.; Kawamura, K.; Masson-Delmotte, V. et al

in Geophysical Research Letters (2017)

The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric ... [more ▼]

The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric reanalyses are relatively unconstrained in this region, resulting in a large spread of estimated 30-year recent warming trends, which limits their use to investigate the mechanisms responsible for this trend. Here, we present a surface temperature reconstruction over 1982-2011 at NEEM (51∘ W, 77∘ N), in North Greenland, based on the inversion of borehole temperature and inert gas isotope data. We find that NEEM has warmed by 2.7±0.33∘C over the past 30 years, from the long-term 1900-1970 average of -28.55±0.29∘C. The warming trend is principally caused by an increase in downward longwave heat flux. Atmospheric reanalyses underestimate this trend by 17%, underlining the need for more in situ observations to validate reanalyses. [less ▲]

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See detailUse of a metagenetic approach to monitor the bacterial microbiota of “Tomme d’Orchies” cheese during the ripening process
Ceugniez, Alexandre; Taminiau, Bernard ULiege; Coucheney, Françoise et al

in International Journal of Food Microbiology (2017), 247

The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade ... [more ▼]

The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade, particularly those performed on milk and cheese derivative products. In this work, we investigated the bacterial content of "Tomme d'Orchies" cheese, an artisanal pressed and uncooked French cheese. To this end, a metagenetic analysis, using Illumina technology, was utilized on samples taken from the surface and core of the cheese at 0, 1, 3, 14 and 21 days of ripening process. In addition to the classical microbiota found in cheese, various strains likely from environmental origin were identified. A large difference between the surface and the core content was observed within samples withdrawn during the ripening process. The main species encountered in the core of the cheese were Lactococcus spp. and Streptococcus spp., with an inversion of this ratio during the ripening process. Less than 2.5% of the whole population was composed of strains issued from environmental origin, as Lactobacillales, Corynebacterium and Brevibacterium. In the core, about 85% of the microbiota was attributed to the starters used for the cheese making. In turn, the microbiota of the surface contained less than 30% of these starters and interestingly displayed more diversity. The predominant genus was Corynebacterium sp., likely originating from the environment. The less abundant microbiota of the surface was composed of Bifidobacteria, Brevibacterium and Micrococcales. To summarize, the “Tomme d’Orchies” cheese displayed a high diversity of bacterial species, especially on the surface, and this diversity is assumed to arise from the production environment and subsequent ripening process. [less ▲]

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See detailL'arrêt de la Cour de cassation du 24 novembre 2016 en matière de funding loss
Delforge, Cécile ULiege

in Chroniques Notariales (2017)

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See detailScaling Theory of the Anderson Transition in Random Graphs: Ergodicity and Universality
Garcia-Mata, Ignacio; Giraud, Olivier; Georgeot, Bertrand et al

in Physical Review Letters (2017), 118

We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that ... [more ▼]

We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that a single transition separates a localized phase from an unusual delocalized phase that is ergodic at large scales but strongly nonergodic at smaller scales. In the critical regime, multifractal wave functions are located on a few branches of the graph. Different scaling laws apply on both sides of the transition: a scaling with the linear size of the system on the localized side, and an unusual volumic scaling on the delocalized side. The critical scalings and exponents are independent of the branching parameter, which strongly supports the universality of our results. [less ▲]

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See detailMetabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibition
Hendrick, Elodie ULiege; Peixoto, Paul; Blomme, Arnaud et al

in Oncogene (2017)

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See detailAssessment of bacterial superficial contamination in classical or ritually slaughtered cattle using metagenetics and microbiological analysis
Korsak Koulagenko, Nicolas ULiege; Taminiau, Bernard ULiege; Hupperts, Caroline et al

in International Journal of Food Microbiology (2017), 247

The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological ... [more ▼]

The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological procedures and 16S rDNA metagenetics. The purpose was also to investigate the neck area to identify bacteria originating from the digestive or the respiratory tract. Twenty bovine carcasses (10 from each group) were swabbed at the slaughterhouse, where both slaughtering methods are practiced. Two swabbing areas were chosen: one “legal” zone of 1,600 cm2 (composed of zones from rump, flank, brisket and forelimb) and locally on the neck area (200 cm2). Samples were submitted to classical microbiology for aerobic Total Viable Counts (TVC) at 30°C and Enterobacteriaceae counts, while metagenetic analysis was performed on the same samples. The classical microbiological results revealed no significant differences between both slaughtering practices; with values between 3.95 and 4.87 log CFU/100 cm2 and 0.49 and 1.94 log CFU/100 cm2, for TVC and Enterobacteriaceae respectively. Analysis of pyrosequencing data showed that differences in the bacterial population abundance between slaughtering methods were mainly observed in the “legal” swabbing zone compared to the neck area. Bacterial genera belonging to the Actinobacteria phylum were more abundant in the “legal” swabbing zone in “Halal” samples, while Brevibacterium and Corynebacterium were encountered more in “Halal” samples, in all swabbing areas. This was also the case for Firmicutes bacterial populations (families of Aerococcaceae, Planococcaceae). Except for Planococcoceae, the analysis of Operational Taxonomic Unit (OTU) abundances of bacteria from the digestive or respiratory tract revealed no differences between groups. In conclusion, the slaughtering method does not influence the superficial microbiological pattern in terms of specific microbiological markers of the digestive or respiratory tract. However, precise analysis of taxonomy at the genus level taxonomy highlights differences between swabbing areas. Although not clearly proven in this study, differences in hygiene practices used during both slaughtering protocols could explain the differences in contamination between carcasses from both slaughtering groups. [less ▲]

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See detailOxidative wear behaviour of laser clad high speed steel thick deposits: influence of sliding speed, carbide type and morphology
Hashemi, Seyedeh Neda ULiege; Mertens, Anne ULiege; Montrieux, Henri-Michel ULiege et al

in Surface & Coatings Technology (2017), 315

The oxidative wear behaviour of four different High Speed Steel (HSS) thick coatings (one cast material and three laser clad deposits with varying Mo, V and W contents) was investigated using a pin-on ... [more ▼]

The oxidative wear behaviour of four different High Speed Steel (HSS) thick coatings (one cast material and three laser clad deposits with varying Mo, V and W contents) was investigated using a pin-on-disc tribometer at two different sliding speeds of 10cm/s and 50cm/s. Microstructural characterisation (before and after the wear tests) was carried out by SEM and wear debris was analysed by XRD. For all four materials, the oxide layer was formed of hard and brittle haematite-type α-Fe2O3, prone to break and release debris that acted as a third body, thus increasing sample wear. The laser clad HSS materials exhibited a higher wear resistance than their conventional cast counterpart, thanks to their finer microstructures. In particular, the coarser MC and M2C carbides present in the cast material were sensitive to cracking during the wear tests, releasing debris that contributed to increased third body abrasion together with oxide fragments. A detailed comparison of the wear behaviour of the three laser clad deposits, in correlation with their different microstructures, further demonstrated that harder V-rich MC carbides offered better wear resistance compared to the softer W-rich M2C carbides. The morphology of the carbides also played a role in determining the wear resistance at the higher sliding speed of 50 cm/s. Clover-shaped primary MC carbides resisted wear better than angular ones due to their better geometric anchoring. Similarly, the geometric anchoring of eutectic M2C carbides, forming a quasi-continuous network at the grain boundaries of the matrix, proved beneficial at higher sliding speed. [less ▲]

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See detailVers une (r)évolution du renseignement belge : la nécessaire émergence d'une communauté du renseignement
Leroy, Patrick ULiege

in Revue "Diplomatie" (2017)

Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles ... [more ▼]

Le renseignement belge entre dans une période de (r)évolution amenée par la crise des attentats qui secouent le sol européen. La tentations est grande pour les décideurs politiques de palier les "failles" du renseignement par des mesures radicales qui pourraient atteindre l'ADN, le coeur de métier du renseignement. [less ▲]

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See detailExtracting residues from stone tools for optical analysis: towards an experiment-based protocol
Cnuts, Dries ULiege; Rots, Veerle ULiege

in Archaeological and Anthropological sciences (2017)

The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they ... [more ▼]

The identification of residues is traditionally based on the distinctive morphologies of the residue fragments by means of light microscopy. Most residue fragments are amorphous, in the sense that they lack distinguishing shapes or easily visible structures under reflected light microscopy. Amorphous residues can only be identified by using transmitted light microscopy, which requires the extraction of residues from the tool’s surface. Residues are usually extracted with a pipette or an ultrasonic bath in combination with distilled water. However, a number of researchers avoid residue extraction because it is unclear whether current extraction techniques are representative for the use-related residue that adheres to a flaked stone tool. In this paper, we aim at resolving these methodological uncertainties by critically evaluating current extraction methodologies. Attention is focused on the variation in residue types, their causes of deposition and their adhesion and on the most successful technique for extracting a range of residue types from the stone tool surface. Based on an experimental reference sample in flint, we argue that a stepwise extraction protocol is most successful in providing rep- resentative residue extractions and in preventing damage, destruction or loss of residue. [less ▲]

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See detailLiver microbiome of Peromyscus leucopus, a key reservoir host species for emerging infectious diseases in North America
André, Adrien ULiege; Mouton, Alice ULiege; millien, virginie et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017)

Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation ... [more ▼]

Microbiome studies generally focus on the gut microbiome, which is composed of a large proportion of commensal bacteria. Here we propose a first analysis of the liver microbiomeusing next generation sequencing as a tool to detect potentially pathogenic strains. We used Peromyscus leucopus, the main reservoir host species of Lyme disease in eastern North America, as a model and sequenced V5-V6 regions of the 16S gene from 18 populations in southern Quebec (Canada). The Lactobacillus genus was found to dominate the liver microbiome.We also detected a large proportion of individuals infected by Bartonella vinsonii arupensis, a human pathogenic bacteria responsible for endocarditis, aswell as Borrelia burgdorferi, the pathogen responsible for Lyme disease in North America. We then compared the microbiomes among two P. leucopus genetic clusters occurring on either side of the St. Lawrence River, and did not detect any effect of the host genotype on their liver microbiome assemblage. Finally, we report, for the first time, the presence of B. burgdorferi in a smallmammal host fromthe northern side of the St. Lawrence River, in support of models that have predicted the northern spread of Lyme disease in Canada. [less ▲]

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See detailAzacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects
Ehx, Grégory ULiege; Fransolet, Gilles ULiege; De Leval, Laurence et al

in Oncoimmunology (2017)

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading ... [more ▼]

The demethylating agent 5-azacytidine (AZA) has proven its efficacy as treatment for myelodysplastic syndrome and acute myeloid leukemia. In addition, AZA can demethylate FOXP3 intron 1 (FOXP3i1) leading to the generation of regulatory T cells (Treg). Here, we investigated the impact of AZA on xenogeneic graft-versus-host disease (xGVHD) and graft-versus-leukemia effects in a humanized murine model of transplantation (human PBMCs-infused NSG mice), and described the impact of the drug on human T cells in vivo. We observed that AZA improved both survival and xGVHD scores. Further, AZA significantly decreased human T-cell proliferation as well as IFN-γ and TNF-α serum levels, and reduced the expression of GRANZYME B and PERFORIN 1 by cytotoxic T cells. In addition, AZA significantly increased Treg frequency through hypomethylation of FOXP3i1 as well as increased Treg proliferation. The later was subsequent to higher STAT5 signaling in Treg from AZA-treated mice, which resulted from higher IL-2 secretion by conventional T cells from AZA-treated mice itself secondary to demethylation of the IL-2 gene promoter by AZA. Importantly, Tregs harvested from AZA-treated mice were suppressive and stable over time since they persisted at high frequency in secondary transplant experiments. Finally, graft-versus-leukemia effects (assessed by growth inhibition of THP-1 cells, transfected to express the luciferase gene) were not abrogated by AZA. In summary, our data demonstrate that AZA prevents xGVHD without abrogating graft-versus-leukemia effects. These findings could serve of basis for further studies of GVHD prevention by AZA in acute myeloid leukemia patients offered an allogeneic transplantation. [less ▲]

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See detailSubstrate Induced Strain Field in FeRh Epilayers Grown on Single Crystal MgO (001) Substrates
Barton, C. W.; Ostler, Thomas ULiege; Huskisson, D. et al

in Scientific Reports (2017), 7

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new ... [more ▼]

Equi-atomic FeRh is highly unusual in that it undergoes a rst order meta-magnetic phase transition from an antiferromagnet to a ferromagnet above room temperature (Tr ≈ 370 K). This behavior opens new possibilities for creating multifunctional magnetic and spintronic devices which can utilise both thermal and applied eld energy to change state and functionalise composites. A key requirement in realising multifunctional devices is the need to understand and control the properties of FeRh in the extreme thin lm limit (tFeRh < 10 nm) where interfaces are crucial. Here we determine the properties of FeRh lms in the thickness range 2.5–10 nm grown directly on MgO substrates. Our magnetometry and structural measurements show that a perpendicular strain eld exists in these thin films which results in an increase in the phase transition temperature as thickness is reduced. Modelling using a spin dynamics approach supports the experimental observations demonstrating the critical role of the atomic layers close to the MgO interface. [less ▲]

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See detailDocking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP) – Insights into a non-canonical and fuzzy interaction
Bessonov, Kyrylo ULiege; Harauz, George; Vassall, Kenrick

in Proteins (2017)

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence ... [more ▼]

The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38–S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily-dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a “sandwich”-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the β-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the β-sheets in Fyn-SH3 and proline-rich region of MBP. [less ▲]

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See detailUnguiculin A and Ptilomycalins E-H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata.
Campos, Pierre-Eric; Wolfender, Jean-Luc; Quieroz, Emerson F. et al

in Journal of Natural Products (2017), 80

Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four ... [more ▼]

Chemical study of the CH2Cl2-MeOH (1:1) extract from the sponge Monanchora unguiculata collected in Madagascar highlighted five new compounds, one acyclic guanidine alkaloid, unguiculin A (1) and four pentacyclic alkaloids, ptilomycalins E-H (2-5), along with four known compounds: crambescidin 800 (6) and crambescidin 359 (7), crambescidic acid (8), and fromiamycalin (9). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. The new ptilomycalin E (2) and the mixture of the new ptilomycalins G (4) and H (5) showed promising cytotoxicity against KB cells with IC50 values of 0.85 and 0.92 μM, respectively. Ptilomycalin F (3) and fromiamycalin (9) exhibited promising activity against Plasmodium falciparum with IC50 values of 0.23 and 0.24 μM, respectively [less ▲]

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See detailRevista "Esfera pública discursiva"
Becerra Mayor, David ULiege

in Esfera pública discursiva (2017), 1

Número 1 de la revista de crítica e información literaria realizada por las y los estudiantes de "Stylistique et critique de l’espagnol moderne" del curso 2016-2017, de la Université de Liège.

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See detailSurgical management of ectopic ureters in dogs: clinical outcome and prognostic factors for long-term continence
Noël, Stéphanie ULiege; Claeys, Stéphanie ULiege; Hamaide, Annick ULiege

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (2017)

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See detailThe effect of concentrate allocation on traffic and milk production of pasture based cows milked by an automatic milking system
Lessire, Françoise ULiege; Froidmont, Eric; Shortall, John et al

in Animal (2017), 11(4), 1-9

Increased economic, societal and environmental challenges facing agriculture are leading to a greater focus on effective way to combine grazing and automatic milking systems (AMS). One of the fundamental ... [more ▼]

Increased economic, societal and environmental challenges facing agriculture are leading to a greater focus on effective way to combine grazing and automatic milking systems (AMS). One of the fundamental aspects of robotic milking is cows’ traffic to the AMS. Numerous studies have identified feed provided, either as fresh grass or concentrate supplement, as the main incentive for cows to return to the robot. The aim of this study was to determine the effect of concentrate allocation on voluntary cow traffic from pasture to the robot during the grazing period, to highlight the interactions between grazed pasture and concentrate allocation in terms of substitution rate and the subsequent effect on average milk yield and composition. Thus, 29 grazing cows, milked by a mobile robot, were monitored for the grazing period (4 months). They were assigned to 2 groups: a low concentrate (LC) group (15 cows) and a high concentrate (HC) group (14 cows) receiving 2 kg and 4 kg concentrate per cow per day respectively. Two allocations per day of fresh pasture were provided at 0700h and 1600h. The cows had to go through the AMS to receive the fresh pasture allocation. The effect of concentrate level on robot visitation was calculated by summing milkings, refusals and failed milkings/cow per day. The impact on average daily milk yield and composition was also determined. The interaction between lactation number and month was used as an indicator of pasture availability. Concentrate allocation increased significantly robot visitations in HC (3.60 ± 0.07 visitations/cow per day in HC - 3.10 ± 0.07 visitations/cow per day in LC; P<0.001) while milkings/cow per day were similar in both groups (LC: 2.37 ± 0.02/day - HC: 2.39 ± 0.02/day; ns). The average daily milk yield over the grazing period was enhanced in HC (22.39 ± 0.22 kg/cow per day in HC- 21.33 ± 0.22 kg/cow per day in LC; P<0.001). However the gain in milk due to higher concentrate supply was limited with regards to the amount of provided concentrates. Milking frequency in HC primiparous compared with LC was increased. In the context of this study, considering high concentrate levels as an incentive for robot visitation might be questioned, as it had no impact on milking frequency and limited impact on average milk yield and composition. By contrast, increased concentrate supply could be targeted specifically to primiparous cows. [less ▲]

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See detailWASP-167b/KELT-13b: Joint discovery of a hot Jupiter transiting a rapidly-rotating F1V star
Temple, L. Y.; Hellier, C.; Albrow, M. D. et al

in Monthly Notices of the Royal Astronomical Society (2017), 471(3), 2743-2752

We report the joint WASP/KELT discovery of WASP-167b/KELT-13b, a transiting hot Jupiter with a 2.02-d orbit around a $V$ = 10.5, F1V star with [Fe/H] = 0.1 $\pm$ 0.1. The 1.5 R$_{\rm Jup}$ planet was ... [more ▼]

We report the joint WASP/KELT discovery of WASP-167b/KELT-13b, a transiting hot Jupiter with a 2.02-d orbit around a $V$ = 10.5, F1V star with [Fe/H] = 0.1 $\pm$ 0.1. The 1.5 R$_{\rm Jup}$ planet was confirmed by Doppler tomography of the stellar line profiles during transit. We place a limit of $<$ 8 M$_{\rm Jup}$ on its mass. The planet is in a retrograde orbit with a sky-projected spin-orbit angle of $\lambda = -165^{\circ} \pm 5^{\circ}$. This is in agreement with the known tendency for orbits around hotter stars to be more likely to be misaligned. WASP-167/KELT-13 is one of the few systems where the stellar rotation period is less than the planetary orbital period. We find evidence of non-radial stellar pulsations in the host star, making it a $\delta$-Scuti or $\gamma$-Dor variable. The similarity to WASP-33, a previously known hot-Jupiter host with pulsations, adds to the suggestion that close-in planets might be able to excite stellar pulsations. [less ▲]

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See detailIdentification of specific posttranslational O-mycoloylations mediating protein targeting to the mycomembrane
Carel, Clément; Marcoux, J; Réat, V et al

in Proceedings of the National Academy of Sciences of the United States of America (2017), 114(16), 42314236

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See detailThe ‘male escape hypothesis’: sex-biased metamorphosis in response to climatic drivers in a facultatively paedomorphic amphibian
Mathiron, Anthony; Lena, Jean-Paul; Baouch, Sarah et al

in Proceedings of the Royal Society B : Biological Sciences (2017), 284(1853), 20170176

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and ... [more ▼]

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and metamorphs dispersing. The evolution of these developmental processes is thought to have been driven by the costs and benefits of inhabiting aquatic versus terrestrial habitats. In this context, we aimed at testing the hypothesis that climatic drivers affect phenotypic transition and the difference across sexes because sex-ratio is biased in natural populations. Through a replicated laboratory experiment, we showed that paedomorphic palmate newts (Lissotriton helveticus) metamorphosed at a higher frequency when water availability decreased and metamorphosed earlier when temperature increased in these conditions. All responses were sex-biased, and males were more prone to change phenotype than females. Our work shows how climatic variables can affect facultative paedomorphosis and support theoretical models predicting life on land instead of in water. Moreover, because males metamorphose and leave water more often and earlier than females, these results, for the first time, give an experimental explanation for the rarity of male paedomorphosis (the ‘male escape hypothesis’) and suggest the importance of sex in the evolution of paedomorphosis versus metamorphosis. [less ▲]

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See detailThe Case of the Decaying Cadaver
Stefanuto, Pierre-Hugues ULiege; Focant, Jean-François ULiege

in The Analytical Scientist (2017), 51

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See detailBaelo Claudia dans l'Antiquité tardive: L'occupation du secteur sud-est du forum entre les IIIe et VIe siècles
Brassous, Laurent; Deru, Xavier ULiege; Rodríguez Gutiérrez, Oliva et al

in Melanges de la Casa de Velazquez (2017), 47(1), 167-200

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon ... [more ▼]

Les recherches archéologiques conduites au sud-est du forum de la ville romaine de Baelo claudia ont permis de mettre au jour au-dessus du secteur monumental, plusieurs phases de transformation, d’abandon et de réoccupation entre les IIIe et VIe s. Les structures découvertes ainsi que le nombreux mobilier qui leur était associé (monnaies, céramique, verre, métal, faune, etc.) fournissent un éclairage nouveau sur l’histoire et la nature de l’agglomération dans l’antiquité tardive, qui entre la fin du IVe s. et son abandon définitif au VIe s. ressemble moins à une ville qu’à un gros village. [less ▲]

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See detailVitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO)
Cianferotti, Luisella; Bertoldo, Francesco; Bischoff-Ferrari, Heike et al

in Endocrine (2017), 56(2), 245-61

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided ... [more ▼]

Introduction Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures. A growing body of literature has provided indirect and some direct evidence for possible extraskeletal vitamin D-related effects. Purpose and Methods Members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis have reviewed the main evidence for possible proven benefits of vitamin D supplementation in adults at risk of or with overt chronic extra-skeletal diseases, providing recommendations and guidelines for future studies in this field. Results and conclusions Robust mechanistic evidence is available from in vitro studies and in vivo animal studies, usually employing cholecalciferol, calcidiol or calcitriol in pharmacologic rather than physiologic doses. Although many cross-sectional and prospective association studies in humans have shown that low 25-hydroxyvitamin D levels (i.e., <50 nmol/L) are consistently associated with chronic diseases, further strengthened by a dose-response relationship, several meta-analyses of clinical trials have shown contradictory results. Overall, large randomized controlled trials with sufficient doses of vitamin D are missing, and available small to moderate-size trials often included people with baseline levels of serum 25-hydroxyvitamin D levels >50 nmol/L, did not simultaneously assess multiple outcomes, and did not report overall safety (e.g., falls). Thus, no recommendations can be made to date for the use of vitamin D supplementation in general, parental compounds, or non-hypercalcemic vitamin D analogs in the prevention and treatment of extra-skeletal chronic diseases. Moreover, attainment of serum 25-hydroxyvitamin D levels well above the threshold desired for bone health cannot be recommended based on current evidence, since safety has yet to be confirmed. Finally, the promising findings from mechanistic studies, large cohort studies, and small clinical trials obtained for autoimmune diseases (including type 1 diabetes, multiple sclerosis, and systemic lupus erythematosus), cardiovascular disorders, and overall reduction in mortality require further confirmation. [less ▲]

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See detailOvertopping induced failure of non-cohesive, homogenous fluvial dikes
Rifai, Ismail ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Water Resources Research (2017), 53(4), 33733386

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of ... [more ▼]

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of sand-filled fluvial dikes were performed, considering a flow parallel to the dike axis. The breach was triggered by overtopping of the dike crest. A detailed monitoring of the transient evolution of the breach geometry was conducted, providing key insights into the gradual and complex processes involved in fluvial dike failure. The breach develops in two phases: (1) the breach becomes gradually wider and deeper eroding on the downstream side along the main channel, and (2) breach widening controlled by side slope failures, continuing in the downstream direction only. Increasing the inflow discharge in the main channel, the breach formation time decreases significantly and the erosion occurs preferentially on the downstream side. The downstream boundary condition has a strong influence on the breach geometry and the resulting outflow hydrograph. [less ▲]

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See detailVille de Liège, reprenez la main ! : politique architecturale de la ville de Liège
De Visscher, Lisa ULiege

in A+ : Architecture in Belgium (2017), 265

Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of ... [more ▼]

Liège is more than an imposing train station. Some major urban developments and small interventions at the level of a neighborhood redesign the city. Several important actors intervene in the process of mutation in Liege, which is why a thorough architectural policy of the City of Liège must make a difference. [less ▲]

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See detailPlantations et bornage : prérogatives d'un emphytéote
Popa, Ruxandra ULiege

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2017), 3-4(2017),

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See detailétude sur l'intolérance à l'incertitude et ses biais cognitifs chez les parents d'un enfant en rémission d'un cancer
Vander Haegen, Marie ULiege; Etienne, Anne-Marie ULiege; Piette, Caroline

in Revue Médicale de Liège (2017), 72

Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant ... [more ▼]

Résumé : Les études en oncologie pédiatrique décrivent une relativement bonne qualité de vie chez les enfants survivants de cancer. À ce jour, peu d’études se sont intéressées aux parents d’un enfant survivant de cancer. Soixante-et-un parents sont recrutés dans les hôpitaux belges. Trois groupes de parents sont constitués : les parents dont l’enfant est à 4 ans de rémission (groupe 1), à 5 ans de rémission (groupe 2) et à 6 ans de rémission (groupe 3). Des échelles cliniques et une tâche de Stroop émotion sont administrées. Les parents (des 3 groupes) présentent une faible tolérance à l’incertitude, ont des inquiétudes excessives quant à l’évolution de la santé de leur enfant et souffrent de symptômes anxieux. Le Stroop émotion révèle un biais cognitif de l’attention en faveur des stimuli de nature menaçante. L’étude met en exergue l’importance de détecter les parents intolérants à l’incertitude lors du diagnostic d’annonce du cancer et leur suivi psychologique continu une fois les traitements terminés. [less ▲]

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See detailCartographie de la disponibilité en eau et en éléments nutritifs des stations forestières de Wallonie
Wampach, Florent ULiege; Lisein, Jonathan; Cordier, Sophie ULiege et al

in FORÊT.NATURE (2017), avril-mai-juin(143), 47-60

Grâce aux données cartographiques de plus en plus nombreuses et disponibles, il est maintenant possible d'analyser l'adéquation essence-station à l'échelle d'un massif ou d'un cantonnement. A l'échelle ... [more ▼]

Grâce aux données cartographiques de plus en plus nombreuses et disponibles, il est maintenant possible d'analyser l'adéquation essence-station à l'échelle d'un massif ou d'un cantonnement. A l'échelle plus locale, cette nouvelle cartographie constitue un outil d'aide à l'interprétation des stations pour les gestionnaires, forestiers ou naturalistes. [less ▲]

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See detailPrimary hypertrophic osteoarthropathy due to a novel SLCO2A1 mutation masquerading as acromegaly
Mangupli, Ruth; Daly, Adrian ULiege; Cuauro, Elvia et al

in Endocrinology, Diabetes and Metabolism Case Reports (2017)

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See detailUse of cis-atracurium to maintain moderate neuromuscular blockade in experimental pigs
Tutunaru, Alexandru-Cosmin ULiege; Dupont, Julien ULiege; Serteyn, Didier ULiege et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailZonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis.
Lesage, Julien; Suarez-Carmona, Meggy; Neyrinck-Leglantier, Deborah et al

in FASEB Journal (2017), 31(4), 1678-1688

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the ... [more ▼]

Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cytonuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1. Moreover, by using mutated promoter constructs, we identified a NF-κB site as critical in this activation. Furthermore, NF-κB pathway signaling analysis revealed both IκBα and p65 phosphorylation in ZO-1-overexpressing cells, and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction. Investigation of the functional implication of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vivo angiogenesis assays. Finally, we found that non-small-cell lung carcinoma that presented a cytonuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1 expression. Taken together, our results demonstrate that ZO-1 regulates CXCL8/IL-8 expression via the NF-κB signaling pathway and its p65 subunit, which subsequently modulates the transcription of IL-8. We also provide evidence of a newly identified regulatory pathway that could promote angiogenesis. Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment. [less ▲]

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