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See detailEffective components of interventions in juvenile justice facilities: How to take care of delinquent youths?
Mathys, Cécile ULg

in Children and Youth Services Review (2017), 73

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in ... [more ▼]

Therapeutic interventions support change in delinquent youths rather than rely on surveillance and deterrence. This article describes successful and concrete components for therapeutic interventions in juvenile justice facilities. The effectiveness of remedial measures to best address the sources of youths' delinquent behaviors and the performance of juvenile justice system are discussed first, and then two theoretical frameworks of rehabilitative models are described that are commonly used with delinquent youths. Finally, specific recommendations for enhancing treatment in juvenile justice facilities with regard to the content of interventions, social climate, and youth motivation to engage in treatment are described and explained in a way intended to help caregivers and practitioners, supervisors of juvenile justice facilities, and policy makers improve the daily life of youths placed in this kind of environment. [less ▲]

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See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULg; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailSampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study
Thiry, Justine ULg; Evrard, Brigitte ULg; Nys, Gwenaël ULg et al

in Journal of Chromatography. A (2017), 1479

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to ... [more ▼]

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to collect small quantities (10 or 20 µL) of whole blood, thereby limiting the amount of animals needed. In this study, a quantitative method was developed and subsequently validated for the poorly soluble drug itraconazole (ITZ) using VAMS and ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS). A proof of concept study showed that the optimized method is applicable to test the bioavailability of drug formulations containing ITZ. Using VAMS, smaller blood volumes can be taken per sampling point (10-20 µL instead of the conventional 0.2-0.5 mL) avoiding the sacrifice of animals. Moreover, the same rats can be used to compare different drug formulations which strengthens the validity of the results. In long-term bioavailability studies, it is necessary to guarantee the stability of the tested drugs supported on VAMS devices. In this study, we show that ITZ was only stable for 24 hours after collection with VAMS, but for at least two weeks by the storage of extracted samples at -80°C. [less ▲]

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See detailDermatophytes and Dermatophytoses: A Thematic Overview of State of the Art, and the Directions for Future Research and Developments
Bouchara, JP; Mignon, Bernard ULg; Chaturvedi, V

in Mycopathologia (2017), 182(1), 1-4

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See detailCooking Has Variable Effects on the Fermentability in the Large Intestine of the Fraction of Meats, Grain Legumes, and Insects That Is Resistant to Digestion in the Small Intestine in an in Vitro Model of the Pig’s Gastrointestinal Tract
POELAERT, Christine ULg; Despret, Xavier; Sindic, Marianne ULg et al

in Journal of Agricultural and Food Chemistry (2017), 65

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal ... [more ▼]

This study aimed to evaluate the fermentation in the large intestine of indigestible dietary protein sources from animal, insect, and plant origin using an in vitro model of the pig’s gastrointestinal tract. Protein sources were used raw and after a cooking treatment. Results showed that the category of the ingredient (meats, insects, or grain legumes) exerts a stronger impact on enzymatic digestibility, fermentation patterns, and bacterial metabolites such as short-chain fatty acids (SCFA) and hydrogen sulfide (H2S) than the cooking treatment. The digestibility and the fermentation characteristics of insects were more affected by the cooking procedure than the other categories. Per gram of consumed food, ingredients from animal origin, namely, meats and insects, were associated with fewer fermentation end-products (gas, H2S, SCFA) than ingredients from plant origin, which is related to their higher small intestinal digestibility. [less ▲]

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See detailPIV-based estimation of unsteady loads on a flat plate at high angle of attack using momentum equation approaches
Guissart, Amandine ULg; Bernal, Luis; Dimitriadis, Grigorios ULg et al

in Experiments in Fluids (2017), 58(5), 53

This work presents, compares and discusses results obtained with two indirect methods for the cal culation of aerodynamic forces and pitching moment from 2D Particle Image Velocimetry (PIV) measurements ... [more ▼]

This work presents, compares and discusses results obtained with two indirect methods for the cal culation of aerodynamic forces and pitching moment from 2D Particle Image Velocimetry (PIV) measurements. Both methodologies are based on formulations of the momentum balance: the integral Navier-Stokes equations and the “flux equation” proposed by Noca et al. (1999), which has been extended to the computation of moments. The indirect methods are applied to spatio-temporal data for different separated flows around a plate with a 16:1 chord-to-thickness ratio. Experimental data are obtained in a water channel for both a plate undergoing a large amplitude imposed pitching motion and a static plate at high angle of attack. In addition to PIV data, direct measurements of aerodynamic loads are carried out to assess the quality of the indirect calculations. It is found that indirect methods are able to compute the mean and the temporal evolution of the loads for two-dimensional flows with a reasonable accuracy. Nonetheless, both methodologies are noise sensitive and, the parameters impacting the computation should thus be chosen carefully. It is also shown that results can be improved through the use of Dynamic Mode Decomposition (DMD) as a pre-processing step. [less ▲]

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See detailMicrostructural and functional correlates of glutamate concentration in the posterior cingulate cortex.
Arrubla Martinez, Jorge Andres ULg; Farrher, Ezequiel; Strippelmann, Johanna et al

in Journal of Neuroscience Research (2017)

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers ... [more ▼]

Glutamate is the major excitatory neurotransmitter in the human brain and has a central role in both intrinsic and stimulus-induced activity. We conducted a study in a cohort of healthy, male volunteers in which glutamate levels were measured in the posterior cingulate cortex (PCC) using 1H magnetic resonance spectroscopy at 3T. The advantages of simultaneous electroencephalography and magnetic resonance imaging (EEG-MRI) were exploited and the subjects were measured in the same session and under the same physiological conditions. Diffusion tensor imaging (DTI), functional MRI (fMRI) and EEG were measured in order to investigate the functional and microstructural correlates of glutamate. The concentration of glutamate (institute units) was calculated and those values were tested for correlation with the metrics of resting state fMRI, DTI, and EEG electrical sources. Our results showed that the concentration of glutamate in the PCC had a significant negative correlation with the tissue mean diffusivity in the same area. The analysis of resting state networks did not show any relationship between the concentration of glutamate and the intrinsic activity of the resting state networks. The concentration of glutamate showed a positive correlation with the electrical generators of alpha-1 frequency and a negative correlation with the generators of alpha-2 and beta-1 electrical generators. (c) 2017 Wiley Periodicals, Inc. [less ▲]

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See detailCounting the number of non-zero coefficients in rows of generalized Pascal triangles
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Discrete Mathematics (2017), 340

This paper is about counting the number of distinct (scattered) subwords occurring in a given word. More precisely, we consider the generalization of the Pascal triangle to binomial coefficients of words ... [more ▼]

This paper is about counting the number of distinct (scattered) subwords occurring in a given word. More precisely, we consider the generalization of the Pascal triangle to binomial coefficients of words and the sequence (S(n))n≥0 counting the number of positive entries on each row. By introducing a convenient tree structure, we provide a recurrence relation for (S(n))n≥0. This leads to a connection with the 2-regular Stern–Brocot sequence and the sequence of denominators occurring in the Farey tree. Then we extend our construction to the Zeckendorf numeration system based on the Fibonacci sequence. Again our tree structure permits us to obtain recurrence relations for and the F-regularity of the corresponding sequence. [less ▲]

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See detailEditor's Choice - Management of Descending Thoracic Aorta Diseases: Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS).
Riambau, V.; Bockler, D.; Brunkwall, J. et al

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2017), 53(1), 4-52

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See detailResponse to the discussion on “Reconstruction of the envelope of non-Gaussian structural responses with principal static wind loads by N. Blaise, T. Canor and V. Denoël”
Blaise, Nicolas; Canor, Thomas; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2017)

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See detailThe lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation
Sayyed, Sufyan Ali ULg; JOURET, François ULg; Vermeersch, Marjorie et al

in Kidney International (2017)

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body ... [more ▼]

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knock-out mice, proximal tubule-specific Ship2 knock-out mice and a proximal tubule cell model where SHIP2 is inactivated, we show that SHIP2 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule. We found increased PtdIns(4,5)P2 substrate and decreased PtdIns4P product when SHIP2 was inactivated, associated with hyperactivated Ezrin/Radixin/Moesin proteins and increased Rho-GTP. Thus, inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule. This may represent an innovative therapeutic target for renal Fanconi syndromes characterized by decreased reabsorption of solutes by this nephron segment. [less ▲]

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See detailThe diplomacy of practitioners: for an ecology of practices about the problem of the coexistence of wind farms and red kites
Melard, François ULg; Stassart, Pierre M ULg

in Environmental Education Research (2017)

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an ... [more ▼]

Gathering information, comparing points of view, and designing actions in and about problematic situations are no longer purely academic activities. Learning about complex state of a airs is becoming an increasingly widely- distributed necessity and practice, including within civil society. We propose to give rst-hand information – as practitioners and members of a citizens’ wind energy co-operative in Belgium – about the problematic and highly controversial coexistence between wind farms and red kite (Milvus milvus). Will be reported the implementation of a community-based management scheme involving active, original practices of collaboration between citizens with local knowledge and skills and experts or scientists in order to produce research and intervention questions, methods, and results that are claimed to be more sustainable. The sustainability challenges are to design and set up in context a local space for collaboration and learning that departs from traditional public regulatory procedures (i.e. impact studies, public information meetings, etc.). However, the outcomes of this collaborative approach remain fragile. We shall argue in this regard that both the Transdisciplinary Environmental Research and the art of diplomacy may be central to the emergence of re exive governance within transition processes that strive to be sustainable. [less ▲]

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See detailRecovery of fibers and biomethane from banana peduncles biomass through anaerobic digestion
AwedemWobiwo, Florent; Korangi Alleluya, Virginie; Happi Emaga, Thomas et al

in Energy for Sustainable Development (2017), 37

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See detailIntegration of order picking and vehicle routing in a B2C e-commerce context
Moons, Stef; Ramaekers, Katrien; Caris, An et al

in Flexible Services and Manufacturing Journal (2017)

E-commerce sales are increasing every year and customers who buy goods on the Internet have high service level expectations. In order to meet these expectations, a company’s logistics operations need to ... [more ▼]

E-commerce sales are increasing every year and customers who buy goods on the Internet have high service level expectations. In order to meet these expectations, a company’s logistics operations need to be performed carefully. Optimizing only internal warehouse processes will often lead to suboptimal solutions. The interrelationship between the order picking process and the delivery process should not be ignored. Therefore, in this study, an order picking problem and a vehicle routing problem with time windows and release dates are solved simultaneously using a single optimization framework. To the best of our knowledge, it is the first time that an order picking problem and a vehicle routing problem are integrated. A mixed integer linear programming formulation for this integrated order picking-vehicle routing problem (OP-VRP) is provided. The integrated OPVRP is solved for small instances and the results are compared to these of an uncoordinated approach. Computational experiments show that integration can lead to cost savings of 14% on average. Furthermore, higher service levels can be offered by allowing customers to request their orders later and still get delivered within the same time windows. [less ▲]

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See detailAssessment of corrosion resistance, material properties, and weldability of alloyed steel for ballast tanks
De Baere, Kris; Verstraelen, Helen; Willemen, Remke et al

in Journal of Marine Science & Technology (2017), 22(1), 176-199

Ballast tanks are of great importance in the lifetime of modern merchant ships. Making a ballast tank less susceptible to corrosion can, therefore, prolong the useful life of a ship and, thereby, lower ... [more ▼]

Ballast tanks are of great importance in the lifetime of modern merchant ships. Making a ballast tank less susceptible to corrosion can, therefore, prolong the useful life of a ship and, thereby, lower its operational cost. An option to reinforce a ballast tank is to construct it out of a corrosion-resistant steel type. Such steel was recently produced by POSCO Ltd., South Korea. After 6 months of permanent immersion, the average corrosion rate of A and AH steel (31 samples) was 535 g m−2 year−1, while the Korean CRS was corroding with 378 g m−2 year−1. This entails a gain of 29 %. Follow-up measurements after 10, 20, and 24 months confirmed this. The results after 6 months exposure to alternating wet/dry conditions are even more explicit. Furthermore, the physical and metallurgical properties of this steel show a density of 7.646 t/m3, the elasticity modulus 209.3 GPa, the tensile strength 572 MPa, and the hardness 169HV10. Microscopically, the metal consists of equiaxed and recrystallized grains (ferrite and pearlite), with an average size of between 20 and 30 µm (ASTM E 112—12 grain size number between 7 and 8) with a few elongated pearlitic grains. The structure is banded ferrite/pearlite. On the basis of a series of energy dispersive X-ray spectrometer measurements the lower corrosion rate of the steel can be attributed to the interplay of Al, Cr, their oxides, and the corroding steel. In addition, the role of each element in the formation of oxide layers and the mechanisms contributing to the corrosion resistance are discussed. [less ▲]

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See detailRectal cancer treatment in a teaching hospital
Verdin, Vanessa; Weerts, Joseph; Francart, David et al

in Acta Chirurgica Belgica (2017), 117

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards ... [more ▼]

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards. Methods: We performed a retrospective study of 95 patients operated on for rectal denocarcinoma in a single institution during the period 2007-2009. We used logistic regression to estimate the relationship between possible predictive parameters of AL. Results: The laparoscopic approach is favored in 63.1% of the cases with a conversion rate of 11.6%, mainly in man (6 out of 7). For low rectal cancer though, laparotomy was the first choice (92.3%). From a carcinological point of view, laparoscopy allowed a complete tumor resection according to the PME (n=27) and TME (n=26) standards. Multivariate analysis revealed that women, lower BMI, lower rectum tumor, laparoscopic surgery, neoadjuvant treatment and anal suture were associated with higher risk of AL. The mean hospital stay was 15.4 days (3 – 46 days). In-hospital mortality was 3.1%. Adjuvant chemotherapy was completed in 42.1% of the patients. Despite these treatments, we registered a recurrence rate of 26.6%. Of these, 72% were distally localized and 12% exclusively locally. Among the patients operated on by laparoscopy, there was one local recurrence and one local with distant metastases (3.7%). The one- and three-years survival rates were 91.5% and 80.4% respectively. Conclusions: Our study showed a higher rate of AL than expected (18%). In our series recorded in PROCARE-Home, our leak rate has dropped to 10%. It may be indicating a positive effect of PROCARE. [less ▲]

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See detailSpatiotemporal variation of drought characteristics in the Huang- Huai-Hai Plain, China under the climate change scenario
Li, Xiangxiang; Ju, Hui; Garré, Sarah ULg et al

in Journal of Integrative Agriculture (2017)

Understanding the potential drought characteristics under climate change is essential to reduce vulnerability and establish adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain), which ... [more ▼]

Understanding the potential drought characteristics under climate change is essential to reduce vulnerability and establish adaptation strategies, especially in the Huang-Huai-Hai Plain (3H Plain), which is the grain production base in China. In this paper, we investigated the variations in drought characteristics (drought event frequency, duration, severity, and intensity) for the past 50 years (1961–2010) and under future scenarios (2010–2099), based on the observed meteorological data and the RCP 8.5 scenario, respectively. First, we compared the applicability of three climatic drought indices: the standardized precipitation index (SPI), the standardized precipitation evapotranspiration index based on the Penman-Monteith equation (SPEI-PM) and the Thornthwaite equation (SPEI-TH) to trace the recorded agricultural drought areas. Then, we analyzed the drought characteristics using “run theory” for both historical observations and future RCP 8.5 scenario based on proper index. Correlation analyses between drought indices and agricultural drought areas showed that SPEI-PM performed better than SPI and SPEI-TH in the 3H Plain. Based on the results of SPEI-PM, the past 50 years have experienced reduced drought of shorter duration, and of weaker severity and intensity. However, under the future RCP 8.5 scenario, drought is expected to rise in frequency, duration, severity, and intensity from 2010–2099, although drought components during the 2010–2039 are predicted to be milder compared with the historical conditions. This study highlights that the estimations for atmospheric evaporative demand would bring in differences in the prediction of long-term drought trends by different drought indices. The results of this study can help inform researchers and local policy makers to establish drought management strategies [less ▲]

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See detailATLANTIC-FRUGIVORY: A PLANT-FRUGIVORE INTERACTION DATASET FOR THE ATLANTIC FOREST
Bello, C; Galetti, M; Montan, D et al

in Ecology (2017)

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See detailEffect of steam explosion treatment on chemical composition and characteristic of organosolv fescue lignin
Maniet, Guillaume ULg; Schmetz, Quentin ULg; Jacquet, Nicolas ULg et al

in Industrial Crops and Products (2017), 99

Tall fescue, a grass currently grown as forage, presents a good potential as a feedstock in the developmentof biorefining. In this study, combination of steam explosion and an acetic/formic acid ... [more ▼]

Tall fescue, a grass currently grown as forage, presents a good potential as a feedstock in the developmentof biorefining. In this study, combination of steam explosion and an acetic/formic acid “organosolv”pretreatments are applied on raw fescue to optimize lignin extraction yields and obtain specific products.In a first step, fescue is pretreated by steam explosion under severity factors from 1.4 to 4.2. Thesetreatments allow hemicelluloses solubilization and open the lignocellulosic structure. Steam explodedsolid residues are then treated with an acetic acid (50%)/formic acid (30%)/water (20%) mixture. Extractedlignins are precipitated and characterized by size exclusion chromatography (SEC),31P NMR and HSQCNMR. Results show that acetic and formic acids extracted lignins present G, H and S units with ferulate andp-coumarate. Lignin typical linkages identified are of -O-4 and spirodienone substructures. Combinationof steam explosion and acetic and formic acid pretreatments increases extraction yields from 30% to100%. Moreover, an increase of the steam explosion treatment intensity induces chemical modificationsin lignin structure such -O-4 and spirodienone substructure degradations, increase of free COOH andphenolic OH bonds, decrease of aliphatic OH ferulate and p-coumarate bonds and changes in G/H/S unitsproportions. Steam explosion intensity affects also lignin molecular weights. [less ▲]

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See detailExploring sex differences in the adult zebra finch brain: in vivo diffusion tensor imaging and ex vivo super-resolution track density imaging
Hamaide, J.; De Groof, G.; Van Steenkiste, G. et al

in NeuroImage (2017)

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural ... [more ▼]

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural investigation of the zebra finch brain has been performed ex vivo using invasive methods such as histology. These methods are highly specific, however, they strongly interfere with performing whole-brain analyses and exclude longitudinal studies aimed at establishing causal correlations between neuroplastic events and specific behavioral performances. Therefore, the aim of the current study was to implement an in vivo Diffusion Tensor Imaging (DTI) protocol sensitive enough to detect structural sex differences in the adult zebra finch brain. Voxel-wise comparison of male and female DTI parameter maps shows clear differences in several components of the song control system (i.e. Area X surroundings, the high vocal center (HVC) and the lateral magnocellular nucleus of the anterior nidopallium (LMAN)), which corroborate previous findings and are in line with the clear behavioral difference as only males sing. Furthermore, to obtain additional insights into the 3-dimensional organization of the zebra finch brain and clarify findings obtained by the in vivo study, ex vivo DTI data of the male and female brain were acquired as well, using a recently established super-resolution reconstruction (SRR) imaging strategy. Interestingly, the SRR-DTI approach led to a marked reduction in acquisition time without interfering with the (spatial and angular) resolution and SNR which enabled to acquire a data set characterized by a 78μm isotropic resolution including 90 diffusion gradient directions within 44h of scanning time. Based on the reconstructed SRR-DTI maps, whole brain probabilistic Track Density Imaging (TDI) was performed for the purpose of super resolved track density imaging, further pushing the resolution up to 40μm isotropic. The DTI and TDI maps realized atlas-quality anatomical maps that enable a clear delineation of most components of the song control and auditory systems. In conclusion, this study paves the way for longitudinal in vivo and high-resolution ex vivo experiments aimed at disentangling [less ▲]

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See detailDrought, conflict and children’s undernutrition in Ethiopia 2000–2013: a meta-analysis
Delbiso, Tefera Darge; Rodriguez-Llanes, Jose Manuel; Donneau, Anne-Françoise ULg et al

in Bulletin of the World Health Organization (2017), 95

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See detailThe neural bases of proactive and reactive control processes in normal aging
Manard, Marine ULg; François, Sarah ULg; Phillips, Christophe ULg et al

in Behavioural Brain Research (2017), 320

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain ... [more ▼]

Introduction. Research on cognitive control suggests an age-related decline in proactive control abilities (anticipatory control), whereas reactive control (following conflict detection) seems to remain intact. As proactive and reactive control abilities are associated with specific brain networks, this study investigated age-related effects on the neural substrates associated with each kind of control. Methods. In an event-related fMRI study, a modified version of the Stroop task was administered to groups of 20 young and 20 older healthy adults. Based on the theory of dual mechanisms of control, the Stroop task has been built to induce proactive or reactive control depending on task context. Results. Behavioral results (p < .05) indicated faster processing of interfering items in the mostly incongruent (MI) than the mostly congruent (MC) context in both young and older participants. fMRI results showed that reactive control is associated with increased activity in left frontal areas for older participants. For proactive control, decreased activity in the bilateral anterior cingulate cortex was associated with more activity in the right middle frontal gyrus in the older than the younger group. Conclusion. These observations support the hypothesis that aging affects the neural networks associated with reactive and proactive cognitive control differentially. These age-related changes are very similar to those observed in young adults with low dopamine availability, suggesting that a general mechanism (prefrontal dopamine availability) may modulate brain networks associated with various kinds of cognitive control. [less ▲]

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See detailGuidelines for the Detection of Babesia and Theileria Parasites.
Lempereur, Laetitia ULg; Beck, Relja; Fonseca, Isabel et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017), 17(1), 51-65

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They ... [more ▼]

The genera Babesia and Theileria (phylum Apicomplexa, order Piroplasmida) are mainly transmitted by Ixodid ticks in which the sexual part of their life cycle followed by sporogony takes place. They include protozoan parasites that infect erythrocytes of a variety of vertebrate hosts, including domestic and wild animals, with some Babesia spp. also infecting humans. Babesia sporozoites transmitted in the tick's saliva during the bloodmeal directly infect erythrocytes, where they asexually multiply to produce pear-shaped merozoites in the process of merogony; whereas a pre-erythrocytic schizogonic life stage in leukocytes is found in Theileria and precedes merogony in the erythrocytes. The wide spectrum of Babesia and Theileria species and their dissimilar characteristics with relation to disease severity, transmission, epidemiology, and drug susceptibility stress the importance of accurate detection of babesiosis and theileriosis and their causative agents. These guidelines review the main methods currently used for the detection of Babesia and Theileria spp. for diagnostic purposes as well as epidemiological studies involving their vertebrate hosts and arthropod vectors. Serological methods were not included once they did not indicate current infection but rather exposure. [less ▲]

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See detailSustainability and management control. Exploring and theorizing control patterns in large European firms
Crutzen, Nathalie ULg; Zvezdov, Dimitar; Schaltegger, Stefan

in Journal of Cleaner Production (2017), 143

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See detailMethanol emissions from maize: Ontogenetic dependence to varying light conditions and guttation as an additional factor constraining the flux
Mozaffar, Ahsan ULg; Schoon, N.; Digrado, Anthony ULg et al

in Atmospheric Environment (2017), 152

Because of its high abundance and long lifetime compared to other volatile organic compounds in the atmosphere, methanol (CH3OH) plays an important role in atmospheric chemistry. Even though agricultural ... [more ▼]

Because of its high abundance and long lifetime compared to other volatile organic compounds in the atmosphere, methanol (CH3OH) plays an important role in atmospheric chemistry. Even though agricultural crops are believed to be a large source of methanol, emission inventories from those crop ecosystems are still scarce and little information is available concerning the driving mechanisms for methanol production and emission at different developmental stages of the plants/leaves. This study focuses on methanol emissions from Zea mays L. (maize), which is vastly cultivated throughout the world. Flux measurements have been performed on young plants, almost fully grown leaves and fully grown leaves, enclosed in dynamic flow-through enclosures in a temperature and light-controlled environmental chamber. Strong differences in the response of methanol emissions to variations in PPFD (Photosynthetic Photon Flux Density) were noticed between the young plants, almost fully grown and fully grown leaves. Moreover, young maize plants showed strong emission peaks following light/dark transitions, for which guttation can be put forward as a hypothetical pathway. Young plants’ average daily methanol fluxes exceeded by a factor of 17 those of almost fully grown and fully grown leaves when expressed per leaf area. Absolute flux values were found to be smaller than those reported in the literature, but in fair agreement with recent ecosystem scale flux measurements above a maize field of the same variety as used in this study. [less ▲]

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See detailTowards a chromatographic similarity index to establish localized quantitative structure-retention models for retention prediction: Use of retention factor ratio
Tyteca, Eva ULg; Talebi, M.; Amos, R. et al

in Journal of Chromatography. A (2017), 1486

Quantitative Structure-Retention Relationships (QSRR) have the potential to speed up the screening phase of chromatographic method development as the initial exploratory experiments are replaced by ... [more ▼]

Quantitative Structure-Retention Relationships (QSRR) have the potential to speed up the screening phase of chromatographic method development as the initial exploratory experiments are replaced by prediction of analyte retention based solely on the structure of the molecule. The present study offers further proof-of-concept of localized QSRR modelling, in which the retention of any given compound is predicted using only the most chromatographically similar compounds in the available dataset. To this end, each compound in the dataset was sequentially removed from the database and individually utilized as a test analyte. In this study, we propose the retention factor k as the most relevant chromatographic similarity measure and compare it with the Tanimoto index, the most popular similarity measure based on chemical structure. Prediction error was reduced by up to 8 fold when QSRR was based only on chromatographically similar compounds rather than using the entire dataset. The study therefore shows that the design of a practically useful structural similarity index should select the same compounds in the dataset as does the k-similarity filter in order to establish accurate predictive localized QSRR models. While low average prediction errors (Mean Absolute Error (MAE) < 0.5 min) and slopes of the regression lines through the origin close to 1.00 were obtained using k-similarity searching, the use of the structural Tanimoto similarity index, considered as the gold standard in Quantitative Structure-Activity Relationships (QSAR) studies, generally resulted in much higher prediction errors (MAE > 1 min) and significant deviations from the reference slope of 1.0. The Tanomoto similarity index therefore appears to have limited general utility in QSRR studies. Future studies therefore aim at designing a more appropriate chromatographic similarity index that can then be applied for unknown compounds (that is, compounds which have not been tested previously on the chromatographic system used, but for which the chemical structures are known). © 2016 [less ▲]

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See detailInteractive effects of ultraviolet radiation and thermal stress on two reef-building corals
Courtial, Lucile; Roberty, Stéphane ULg; Shick, Malcom et al

in Limnology and Oceanography (2017)

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULg; Della Vecchia, Gabriele; Charlier, Robert ULg

in Canadian Geotechnical Journal (2017)

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See detailDepth-speci c Fluctuations of gene expression and protein abundance modulate the photophysiology in the seagrass Posidonia oceanica
Procaccini, Gabriele; Ruocco, Miriam; Marin-Guirao, Lazaro et al

in Scientific Reports (2017), 7(42890), 1-14

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light ... [more ▼]

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong di erences in the light environment. The photochemical pathway of energy use was more e ective in shallow plants due to higher light availability, but these plants needed more investment in photoprotection and photorepair, requiring higher translation and protein synthesis than deep plants. The genetic di erentiation between deep and shallow stands suggests the existence of locally adapted genotypes to contrasting light environments. The depth-speci c diel rhythms of photosynthetic and respiratory processes, from molecular to physiological levels, must be considered in the management and conservation of these key coastal ecosystems. [less ▲]

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See detailContrasted terrace systems of the lower Moulouya river as indicator of crustal deformation in NE Morocco
Rixhon, Gilles; Bartz, Melanie; El Ouahabi, Meriam ULg et al

in Journal of African Earth Sciences (2017)

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See detailPEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy
Frère, Antoine ULg; Baroni, Alexandra; Hendrick, Elodie ULg et al

in ACS Applied Materials and Interfaces (2017), 25(9(3)), 2181-2195

Guanidine and morpholine functionalized aliphatic polycarbonate polymers are able to efficiently deliver histone deacetylase 5 (HDAC5) siRNA into the cytoplasm of cancer cells in vitro leading to a ... [more ▼]

Guanidine and morpholine functionalized aliphatic polycarbonate polymers are able to efficiently deliver histone deacetylase 5 (HDAC5) siRNA into the cytoplasm of cancer cells in vitro leading to a decrease of cell proliferation were previously developed. To allow these biodegradable and biocompatible polyplex nanoparticles to overcome the extracellular barriers and be effective in vivo after an intravenous injection, polyethylene glycol chains (PEG750 or PEG2000) were grafted on the polymer structure. These nanoparticles, showed an average size of about 150 nm and a slightly positive zeta potential with complete siRNA complexation. Behavior of PEGylated and non-PEGylated polyplexes were investigated in the presence of serum, in terms of siRNA complexation (Fluorescence Correlation Spectroscopy), size (Dynamic Light Scattering and Single-Particle Tracking), interaction with proteins (Isothermal Titration Calorimetry) and cellular uptake. Surprisingly, both PEGylated and non-PEGylated formulations presented relatively good behavior in the presence of fetal bovine serum (FBS). Hemocompatibility tests showed no effect of these polyplexes on hemolysis and coagulation. In vivo biodistribution in mice was performed and showed a better siRNA accumulation at the tumor site for PEGylated polyplexes. However, cellular uptake in protein-rich conditions showed that PEGylated polyplex lost their ability to interact with biological membranes and enter into cells, showing the importance to perform in vitro investigations in physiological conditions closed to in vivo situation. In vitro, the efficiency of PEGylated nanoparticles decreases compared to non-PEGylated particles, leading to the loss of the antiproliferative effect on cancer cells. [less ▲]

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See detailThe impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: an EADC study
Bosco, P.; Redolfi, A.; Bocchetta, M. et al

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2017)

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See detailInhibition of ethylene synthesis reduces salt-tolerance in tomato wild relative species Solanum chilense
Gharbi, E.; Martínez, J.-P.; Benahmed, H. et al

in Journal of Plant Physiology (2017), 210

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of ... [more ▼]

Exposure to salinity induces a burst in ethylene synthesis in the wild tomato halophyte plant species Solanum chilense. In order to gain information on the role of ethylene in salt adaptation, plants of Solanum chilense (accession LA4107) and of cultivated glycophyte Solanum lycopersicum (cv. Ailsa Craig) were cultivated for 7 days in nutrient solution containing 0 or 125 mM NaCl in the presence or absence of the inhibitor of ethylene synthesis (aminovinylglycine (AVG) 2 μM). Salt-induced ethylene synthesis in S. chilense occurred concomitantly with an increase in stomatal conductance, an efficient osmotic adjustment and the maintenance of carbon isotope discrimination value (Δ13C). In contrast, in S. lycopersicum, salt stress decreased stomatal conductance and Δ13C values while osmotic potential remained higher than in S. chilense. Inhibition of stress-induced ethylene synthesis by AVG decreased stomatal conductance and Δ13C in S. chilense and compromised osmotic adjustment. Solanum chilense behaved as an includer and accumulated high amounts of Na in the shoot but remained able to maintain K nutrition in the presence of NaCl. This species however did not stimulate the expression of genes coding for high-affinity K transport but genes coding for ethylene responsive factor ERF5 and JREF1 were constitutively more expressed in S. chilense than in S. lycopersicum. It is concluded that ethylene plays a key role in salt tolerance of S. chilense. © 2016 [less ▲]

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See detailMemory consolidation in children with Specific Language Impairment: Delayed gains and susceptibility to interference in implicit sequence learning
Desmottes, Lise ULg; Maillart, Christelle ULg; Meulemans, Thierry ULg

in Journal of Clinical and Experimental Neuropsychology (2017)

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language ... [more ▼]

Introduction: In this study, the time course of the procedural learning of a visuomotor sequence skill was followed over a 24-hour and a 1-week time period in children with and without specific language impairment (SLI). Two aspects of memory consolidation in implicit sequence learning were examined: the evolution of post-training gains in sequence knowledge (Experiment 1) and the susceptibility to interference (Experiment 2). Method and Results: In the first experiment, 18 children with SLI and 17 control children matched for sex, age, and nonverbal intelligence completed a serial reaction-time (SRT) task and were tested 24 hours and 1 week after practicing. The two groups of children attained an equal level of sequence knowledge in the training session, but the children with SLI lacked the consolidation gains displayed by the control children in the two post-training sessions. Working with a new group of children, 17 with SLI and 17 control peers, Experiment 2 examined resistance to interference by introducing a second sequence 15 minutes after the first training session. Similar results were obtained for the performance of both groups in the training session. However, although the performance of the control group improved in the post-training sessions, the performance of the SLI group deteriorated significantly during the consolidation phase due to the interfering sequence. Conclusion: These findings suggest that the consolidation phase of sequence learning is impaired in children with SLI. [less ▲]

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See detailApplication of a 3D unsteady surface panel method with flow separation model to horizontal axis wind turbines
Prasad, Chandra Shekhar; Dimitriadis, Grigorios ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2017), 166

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine ... [more ▼]

This work describes the development and application of a 3D unsteady surface panel method with a separation model to the problem of simulating the flow around the blades of a horizontal axis wind turbine. The present method is intended as a design tool to capture the 3D time-dependent characteristics of both attached and separated flow conditions and is an extension of previous 2D approaches. Flow separation is modelled using a loose coupling procedure between the inviscid panel method and a quasi-3D viscous boundary layer solution. A separated wake is shed at the predicted separation points and propagated at the local flow velocity, just like the trailing edge wake. The methodology is demonstrated on the NREL phase-VI wind turbine test case and the model predictions are compared to experimental measurements. [less ▲]

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See detailEcotoxicoproteomic assessment of the functional alterations caused by chronic metallic exposures in gammarids
Gismondi, Eric ULg; Thomé, Jean-Pierre ULg; Urien, Nastassia et al

in Environmental Pollution (2017)

Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health ... [more ▼]

Very few ecotoxicological studies have been performed on long-term exposure under controlled conditions, hence limiting the assessment of the impact of chronic and diffuse chemical pressures on the health of aquatic organisms. In this study, an ecotoxicoproteomic approach was used to assess the integrated response and possible acclimation mechanisms in Gammarus fossarum following chronic exposures to Cd, Cu or Pb, at environmentally realistic concentrations (i.e. 0.25, 1.5 and 5 µg/L respectively). After 10-week exposure, changes in protein expression were investigated in caeca of control and exposed males. Gel-free proteomic analyses allowed for the identification of 35 proteins involved in various biological functions, for which 23 were significantly deregulated by metal exposures. The protein deregulation profiles were specific to each metal, providing evidence for metal-specific action sites and responses of gammarids. Among the tested metals, Cu was the most toxic in terms of mortality, probably linked with persistent oxidative stress. Moulting and osmoregulation were the major biological functions affected by Cu in the long-term. In Pb-exposed gammarids, significant deregulations of proteins involved in immune response and cytoskeleton were observed. Reproduction appears to be strongly affected in gammarids chronically exposed to Cd or Pb. Besides, modified expressions of several proteins involved in energy transfer and metabolism highlighted important energetic reshuffling to cope with chronic metal exposures. These results support the fact that metallic pressures induce a functional and energetic cost for individuals of G. fossarum with potential repercussions on population dynamics. Furthermore, this ecotoxicoproteomic study offers promising lines of enquiry in the development of new biomarkers that could make evidence of long-term impacts of metals on the health of organisms. [less ▲]

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailA multivariable prediction model for pegvisomant dosing: monotherapy and in combination with long-acting somatostatin analogues
Franck, Sanne Elisabeth; Korevaar, Tim; PETROSSIANS, Patrick ULg et al

in European Journal of Endocrinology (2017)

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and ... [more ▼]

Background: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. Objective: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs). 188) were meta-analysed as a form of external replication to study the predictors of PEGV dosing in addition to LA-SSA, the LAS (n=83) was used to study the predictors of PEGV monotherapy dosing. Multivariable regression models were used to identify predictors of the PEGV dose required to normalize IGF-I levels. <0.001, p=<0.001, p=0.028 and p=0.047, respectively). Taken together, these characteristics predicted the PEGV normalization dose correctly in 63.3% of all patients within a range of +/- 60 mg/week (21.3% within a range of +/- 20 mg/week). For monotherapy, only weight was associated with the PEGV normalization dose (p=<0.001) and predicted this dosage correctly in 77.1% of all patients within a range of +/- 60 mg/week (31.3% within a range of +/- 20 mg/week). Conclusion: In this study, we show that IGF-I levels, weight, height and age can contribute to define the optimal PEGV dose in order to normalize IGF-I levels in addition to LA-SSA. For PEGV monotherapy, only the patient's weight was associated with the IGF-I normalization PEGV dosage. [less ▲]

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See detailFalse memory susceptibility in coma survivors with and without a near-death experience
Martial, Charlotte ULg; Charland-Verville, Vanessa ULg; Dehon, Hedwige ULg et al

in Psychological Research (2017)

It has been postulated that memories of neardeath experiences (NDEs) could be (at least in part) reconstructions based on experiencers’ (NDErs) previous knowledge and could be built as a result of the ... [more ▼]

It has been postulated that memories of neardeath experiences (NDEs) could be (at least in part) reconstructions based on experiencers’ (NDErs) previous knowledge and could be built as a result of the individual’s attempt to interpret the confusing experience. From the point of view of the experiencer, NDE memories are perceived as being unrivalled memories due to its associated rich phenomenology. However, the scientific literature devoted to the cognitive functioning of NDErs in general, and their memory performance in particular, is rather limited. This study examined NDErs’ susceptibility to false memories using the Deese–Roediger–McDermott (DRM) paradigm. We included 20 NDErs who reported having had their experience in the context of a life-threatening event (Greyson NDE scale total score ≥7/32) and 20 volunteers (matched for age, gender, education level, and time since brain insult) who reported a life-threatening event but without a NDE. Both groups were presented with DRM lists for a recall task during which they were asked to assign “Remember/Know/Guess” judgements to any recalled response. In addition, they were later asked to complete a post-recall test designed to obtain estimates of activation and monitoring of critical lures. Results demonstrated that NDErs and volunteers were equally likely to produce false memories, but that NDErs recalled them more frequently associated with compelling illusory recollection. Of particular interest, analyses of activation and monitoring estimates suggest that NDErs and volunteers groups were equally likely to think of critical lures, but source monitoring was less successful in NDErs compared to volunteers. [less ▲]

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See detailL’ÉVALUATION DES POLITIQUES PUBLIQUES DANS LE CHAMP DE LA COOPÉRATION AU DÉVELOPPEMENT BELGE : LE CAS DU SERVICE DE L’ÉVALUATION SPÉCIALE
Contor, Justine ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017)

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation ... [more ▼]

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation Spéciale de la coopération belge au développement (SES). Nous présenterons dans ce document les raisons de la création de ce service au début des années 2000. En effet, le SES, avec d’autres acteurs, est le résultat d’une grande réforme de la coopération issue d’une lourde crise. Nous reviendrons sur son mandat, sur ses spécificités organisationnelles (ressources financières et humaines) ainsi que son cadre de référence normatif. La question de la culture évaluative sera questionnée, ainsi que son lien avec l’émergence du New Public Management dans la politique de coopération au développement. Enfin, nous questionnerons la légitimité d’une structure telle que le SES au regard d’un cadrage théorique mixte (Scott, 1995 ; Suchmann, 1995) et de la théorie des parties prenantes. [less ▲]

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See detailAssessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017)

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both ... [more ▼]

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter- and intramolecular strategies imply the telescoping of multiple processing steps and the generation of unstable diazo species under continuous-flow conditions. The intermolecular strategy relies on an unprecedented continuous-flow Rh-catalyzed intermolecular C–H carbene insertion, providing enriched threo-N-Boc methylphenidate in 38% or 19% isolated yield according to sequential or fully telescoped processes, respectively. Quantitative Boc-deprotection is carried out off-line. The intramolecular strategy relies on a continuous-flow thermal intramolecular C–H carbene insertion, providing enriched threo-methylphenidate hydrochloride in 70% isolated yield. A continuous-flow photochemical alternative is also presented. The critical step of the most promising intramolecular strategy is implemented on the mesoscale in a pilot-scale continuous-flow reactor. [less ▲]

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See detailPersistence of the effec of frugivore identity on post-dispersal seed fate: consequences for the assessment of functional redundancy
Lugon, Ana Paula; Boutefeu, Marion; Bovy, Emilie et al

in Biotropica (2017)

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See detailMeta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Jones, Gregory; Tromp, Gerard; Kuivaniemi, Helena et al

in Circulation Research (2017)

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See detailTemperature Preference and Sex Differentiation in African Catfish, Clarias gariepinus
Santi, Saïdou; Rougeot, Carole ULg; Toguyeni, Aboubacar et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (2017)

The African catfish Clarias gariepinus has a genetic sex determination system in which high temperature induces masculinization. The thermosensitive period for sex differentiation is short and occurs very ... [more ▼]

The African catfish Clarias gariepinus has a genetic sex determination system in which high temperature induces masculinization. The thermosensitive period for sex differentiation is short and occurs very early (from 6 to 8 days posthatching [dph]). As young juveniles can encounter high masculinizing temperature (36.5°C) in African water points, we aimed to determine the thermal preference of sexually undifferentiated juveniles and investigate if they spontaneously move toward high masculinizing temperature. Experiments were carried out in an environmental continuum (28–28–28°C and 28–32–36.5°C) made up of three 50-L aquariums connected together. Four hundred larvae from 10 different full-sib progenies were reared successively from 2 to 14 dph in these facilities. Before and after thermal treatments, fish were reared at 28°C until sex ratio determination at 70 dph. In the control continuum, fish were nearly equally distributed in the three compartments. Conversely, in the thermal continuum, compartment occupation significantly differed with progeny and period. During the highly thermosensitive period, two of five progenies significantly preferred (54.7% and 39.8% occupation) the 36.5°C compartment. All tested progenies reared in thermal continuum and separated 36.5°C aquarium showed a skewed sex ratio toward the male phenotype (78–100%). Nevertheless, no correlation was found between 36.5°C compartment occupation and sex ratio in thermal continuum groups. As masculinization temperature could be encountered in African water points during the spawning season, we discussed the adaptive advantage for the African catfish to display a sex differentiation process controlled by a temperature effect. [less ▲]

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See detailAeroservoelastic Simulations for Horizontal Axis Wind Turbines
Prasad, Chandra Shekhar ULg; Chen, Qiong Zhong; Bruls, Olivier ULg et al

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (2017), 231(2), 103-117

This paper describes the development of a complete methodology for the aeroservoelastic modeling of horizontal axis wind turbines at the conceptual design stage. The methodology is based on the ... [more ▼]

This paper describes the development of a complete methodology for the aeroservoelastic modeling of horizontal axis wind turbines at the conceptual design stage. The methodology is based on the implementation of unsteady aerodynamic modeling, advanced description of the control system and nonlinear finite element calculations in the SWT wind turbine design package. The aerodynamic modeling is carried out by means of fast techniques, such as the Blade Element Method and the unsteady Vortex Lattice Method, including a free wake model. The complete model also includes a description of a doubly fed induction generator and its control system for variable speed operation. The SWT software features a non-linear finite element solver with multi-body dynamics capability. The full methodology is used to perform complete aeroservoelastic simulations of a realistic 2MW wind turbine model. The interaction between the three components of the approach is carefully analyzed and presented here. [less ▲]

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See detailSoil organic carbon fractionation for improving agricultural soil quality assessment – a case study in Southern Belgium (Wallonia)
Trigalet, Sylvain; Chartin, Caroline; Krüger, Inken ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(S1),

Description of the subject. The paper presents and discusses a method for fractionating bulk soil organic carbon (SOC) in meaningful SOC fractions to better assess SOC status and its related soil ... [more ▼]

Description of the subject. The paper presents and discusses a method for fractionating bulk soil organic carbon (SOC) in meaningful SOC fractions to better assess SOC status and its related soil ecosystem functions. Objectives. The objective is to perform an evaluation of ecosystem functions of soil organic matter at plot scale and compare it to the normal operative range of the local agro-ecological region. Method. By separating carbon associated with clay and fine silt particles (stable carbon with slow turnover rate, < 20 μm) and carbon non-associated with this fraction (labile and intermediate carbon with higher turnover rates, ≥ 20 μm), effects of management can be detected more efficiently at different scales. Conclusions. Soil organic carbon fractions, used as proxies for soil ecosystem functions, can be helpful because they represent SOC functional pools. This paper proposes to apply fractionation on samples taken at plot and regional scale. It is therefore possible to establish a normal operative range for a specific agro-region for comparison with the values in individual plots. This allows drawing a baseline for SOC fractions status in a specific agricultural unit. This approach provides valuable information to study and evaluate the impact of agricultural management in the context of enhancing soil quality and functions. [less ▲]

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See detailGenomewide association of piglet responses to infection with one of two porcine reproductive and respiratory syndrome virus isolates.
Waide, E. H.; Tuggle, C. K.; Serao, N. V. L. et al

in Journal of Animal Science (2017), 95(1), 16-38

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus ... [more ▼]

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease in the swine industry. Identification of host genetic factors that enable selection for improved performance during PRRS virus (PRRSV) infection would reduce the impact of this disease on animal welfare and production efficiency. We conducted genomewide association study (GWAS) analyses of data from 13 trials of approximately 200 commercial crossbred nursery-age piglets that were experimentally infected with 1 of 2 type 2 isolates of PRRSV (NVSL 97-7985 [NVSL] and KS2006-72109 [KS06]). Phenotypes analyzed were viral load (VL) in blood during the first 21 d after infection (dpi) and weight gain (WG) from 0 to 42 dpi. We accounted for the previously identified QTL in the region on SSC4 in our models to increase power to identify additional regions. Many regions identified by single-SNP analyses were not identified using Bayes-B, but both analyses identified the same regions on SSC3 and SSC5 to be associated with VL in the KS06 trials and on SSC6 in the NVSL trials ( < 5 x 10); for WG, regions on SSC5 and SSC17 were associated in the NVSL trials ( < 3 x 10). No regions were identified with either method for WG in the KS06 trials. Except for the region on SSC4, which was associated with VL for both isolates (but only with WG for NVSL), identified regions did not overlap between the 2 PRRSV isolate data sets, despite high estimates of the genetic correlation between isolates for traits based on these data. We also identified genomic regions whose associations with VL or WG interacted with either PRRSV isolate or with genotype at the SSC4 QTL. Gene ontology (GO) annotation terms for genes located near moderately associated SNP ( < 0.003) were enriched for multiple immunologically (VL) and metabolism- (WG) related GO terms. The biological relevance of these regions suggests that, although it may increase the number of false positives, the use of single-SNP analyses and a relaxed threshold also increased the identification of true positives. In conclusion, although only the SSC4 QTL was associated with response to both PRRSV isolates, genes near associated SNP were enriched for the same GO terms across PRRSV isolates, suggesting that host responses to these 2 isolates are affected by the actions of many genes that function together in similar biological processes. [less ▲]

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See detailEthylene polymerization and hydrodechlorination of 1,2-dichloroethane mediated by nickel(II) covalently anchored to silica xerogels
Mahy, Julien ULg; Claude, Vincent ULg; Sacco, Luigi et al

in Journal of Sol-Gel Science and Technology (2017), 81(1), 59-68

Ni/SiO2 cogelled xerogel catalysts have been prepared in ethanol containing nickel acetylacetonate, tetraethoxysilane (TEOS), an aqueous ammonia solution of 0.54 mol L-1 and either a commercial sylilated ... [more ▼]

Ni/SiO2 cogelled xerogel catalysts have been prepared in ethanol containing nickel acetylacetonate, tetraethoxysilane (TEOS), an aqueous ammonia solution of 0.54 mol L-1 and either a commercial sylilated ligand, 3-(2-aminoethyl)aminopropyltrimethoxysilane (EDAPMS), or a home-made new silylated pyrazolypyridine ligands, respectively 2-[4-[3-(trimethoxysilyl)propyl]-3,5-dimethyl-1H-pyrazol-1-yl]pyridine (MS-PzPy) and 2-[4-[3-(trimethoxysilyl)propyl]-3,5-dimethyl-1H-pyrazol-1-yl]-6-methylpyridine (MS-PzPyMe), able to form a chelate with a metal ion such as Ni2+. All samples form homogeneous and very highly dispersed Ni/SiO2 cogelled xerogel catalysts. The resulting catalysts are composed of nickel nanoparticles with a diameter of about 2.8 nm, located inside primary silica particles exhibiting a monodisperse microporous distribution. The silylated organic ligand has a strong influence on the textural properties of cogelled xerogel catalysts, both before and after calcination and reduction steps. Changing the nature of the silylated ligand permits tailoring textural properties such as pore volume, pore size and surface area. Homogenous nickel complexes synthesized from pyrazolylpyridine derivatives are inactive for ethylene polymerization. In opposite, heterogenous nickel-based catalysts onto silica xerogel synthesized from pyrazolylpyridine derivatives bearing a tethered trialkoxysilyl group allow increasing ethylene polymerization activity. Although nickel nanoparticles are located inside the silica crystallites, their complete accessibility, via the micropore network, has been shown. For 1,2-dichloroethane hydrodechlorination over Ni/SiO2 catalysts, the conversion of 1,2-dichloroethane is high at the temperature of 350°C and mainly ethane is produced. [less ▲]

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See detailChemical Strain Engineering of Magnetism in Oxide Thin Films
Copie, Olivier; Varignon, Julien ULg; Rotella, Hélène et al

in Advanced Materials (2017)

Transition metal oxides having a perovskite structure form a wide and technologically important class of compounds. In these systems, ferroelectric, ferromagnetic, ferroelastic, or even orbital and charge ... [more ▼]

Transition metal oxides having a perovskite structure form a wide and technologically important class of compounds. In these systems, ferroelectric, ferromagnetic, ferroelastic, or even orbital and charge orderings can develop and eventually coexist. These orderings can be tuned by external electric, magnetic, or stress field, and the cross-couplings between them enable important multifunctional properties, such as piezoelectricity, magneto-electricity, or magneto-elasticity. Recently, it has been proposed that additional to typical fields, the chemical potential that controls the concentration of ion vacancies in these systems may reveal an efficient alternative parameter to further tune their properties and achieve new functionalities. In this study, concretizing this proposal, the authors show that the control of the content of oxygen vacancies in perovskite thin films can indeed be used to tune their magnetic properties. Growing PrVO3 thin films epitaxially on an SrTiO3 substrate, the authors reveal a concrete pathway to achieve this effect. The authors demonstrate that monitoring the concentration of oxygen vacancies through the oxygen partial pressure or the growth temperature can produce a substantial macroscopic tensile strain of a few percent. In turn, this strain affects the exchange interactions, producing a nontrivial evolution of Néel temperature in a range of 30 K. [less ▲]

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See detailA French version of the Balanced Time Perspective Scale: Factor structure and relation to cognitive reappraisal.
Barsics, Catherine ULg; Rebetez, Marie; Rochat, Lucien et al

in Canadian Journal of Behavioural Science = Revue Canadienne des Sciences du Comportement (2017), 49(1), 51-57

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated ... [more ▼]

A frequent and equal tendency to think positively about one’s past and future has been conceptualised as a balanced time perspective (TP). Such a dispositional temporal orientation has been associated with higher life satisfaction and happiness. The aim of the present study was to develop and to validate a French version of the Balanced Time Perspective Scale (BTPS; Webster, 2011), which has been specifically designed to assess the combined use of positive future and past mental representations as resources for the self. Data were collected from an online survey in a sample of 622 French-speaking individuals from the general population. Results indicated that the French version of the BTPS replicated the 2-factor structure of the original questionnaire, and showed excellent internal consistency. External validity was supported by specific rela- tionships with measures of TP and positive affect. In addition, a high propensity to project oneself positively both in the future and the past was associated with greater use of cognitive reappraisal. [less ▲]

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See detailThe use of oxytocin to improve feeding and social skills in infants with Prader-Willi syndrome
Tauber, Maïthé; Boulanouar, Kader; Gwenaelle, Diene et al

in Pediatrics (2017), 139(2),

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults ... [more ▼]

BACKGROUND AND OBJECTIVES: Patients with Prader–Willi syndrome (PWS) display poor feeding and social skills as infants and fewer hypothalamic oxytocin (OXT)-producing neurons were documented in adults. Animal data demonstrated that early treatment with OXT restores sucking after birth. Our aim is to reproduce these data in infants with PWS. METHODS: We conducted a phase 2 escalating dose study of a short course (7 days) of intranasal OXT administration. We enrolled 18 infants with PWS under 6 months old (6 infants in each step) who received 4 IU of OXT either every other day, daily, or twice daily. We investigated the tolerance and the effects on feeding and social skills and changes in circulating ghrelin and brain connectivity by functional MRI. RESULTS: No adverse events were reported. No dose effect was observed. Sucking assessed by the Neonatal Oral-Motor Scale was abnormal in all infants at baseline and normalized in 88% after treatment. The scores of Neonatal Oral-Motor Scale and videofluoroscopy of swallowing significantly decreased from 16 to 9 (P < .001) and from 18 to 12.5 (P < .001), respectively. Significant improvements in Clinical Global Impression scale scores, social withdrawal behavior, and mother–infant interactions were observed. We documented a significant increase in acylated ghrelin and connectivity of the right superior orbitofrontal network that correlated with changes in sucking and behavior. CONCLUSIONS: OXT is well tolerated in infants with PWS and improves feeding and social skills. These results open perspectives for early treatment in neurodevelopment diseases with feeding problems. [less ▲]

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See detailLes genres médiatiques de l'anticipation: des usages comiques du futur
Stienon, Valérie ULg

in Médias19 (2017)

La petite presse multiplie les usages comiques de la prédiction, tantôt en empruntant ses effets à l’almanach, tantôt en traitant au second degré les marronniers trop familiers, tantôt encore en ... [more ▼]

La petite presse multiplie les usages comiques de la prédiction, tantôt en empruntant ses effets à l’almanach, tantôt en traitant au second degré les marronniers trop familiers, tantôt encore en infléchissant vers la prospective le principe de la revue de fin d’année. Il est fréquent que les petits journaux satiriques feignent d’imaginer les événements à venir sous la forme de « prédictions pour l’année » et de « coups d’œil prophétiques ». Si de telles éphémérides parodiques ne bénéficient pas de la stabilité d’une rubrique spécifique, elles sont toutefois appelées, au siècle suivant, à prendre l’ampleur de numéros complets qui témoignent d’une postérité intéressante (Illustration, Lectures pour tous, VU, Sciences et voyages) et d’une créativité iconotextuelle qui peut aller jusqu’au faux reportage photographique d’anticipation. Cet article propose de cerner dans sa variété une microforme médiatique inhérente à la modernité de la petite presse. D’une part, sa discursivité porte sur des données socioculturelles présentées comme remarquables et novatrices, censées incarner la quintessence de leur époque tout entière tendue vers l’avenir. D’autre part, sa poétique affiche une temporalité méta-médiatique renvoyant aux fonctions rituelles et référentielles du périodique. [less ▲]

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See detailSpaces Snu, diametral dimension and property Omega bar
Demeulenaere, Loïc ULg

in Journal of Mathematical Analysis and Applications (2017), 449(2), 1340-1350

This paper investigates two topological invariants in the context of the sequence spaces Snu, which are metric topological vector spaces defined in order to study the regularity of signals. First, it ... [more ▼]

This paper investigates two topological invariants in the context of the sequence spaces Snu, which are metric topological vector spaces defined in order to study the regularity of signals. First, it extends the formula already known of the diametral dimension of spaces Snu to some non-locally pseudoconvex ones. Second, it proves that locally p-convex spaces Snu verifies the property "Omega id", which is equivalent to Omega bar for Fréchet spaces. [less ▲]

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See detailA dynamic, sex-specific expression pattern of genes regulating thyroid hormone action in the developing zebra finch song control system
Raymaekers, S.R.; Verbeure, W.; Ter Haar, S.M. et al

in General and Comparative Endocrinology (2017), 240

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel ... [more ▼]

The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excel- lent model to study developmental neuroplasticity. Despite the demonstrated influence of hormones such as sex steroids on this phenomenon, thyroid hormones (THs) – an important factor in neural devel- opment and maturation – have not been studied in this regard. We used in situ hybridization to compare the expression of TH transporters, deiodinases and receptors between both sexes during all phases of song development in male zebra finch. Comparisons were made in four song control nuclei: Area X, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), HVC (used as proper name) and the robust nucleus of the arcopallium (RA). Most genes regulating TH action are expressed in these four nuclei at early stages of development. However, while general expression levels decrease with age, the activating enzyme deiodinase type 2 remains highly expressed in Area X, HVC and RA in males, but not in females, until 90days post-hatch (dph), which marks the end of sensorimotor learning. Furthermore, the L-type amino acid transporter 1 and TH receptor beta show elevated expression in male HVC and RA respectively compared to surrounding tissue until adulthood. Differences compared to sur- rounding tissue and between sexes for the other TH regulators were minor. These developmental changes are accompanied by a strong local increase in vascularization in the male RA between 20 and 30 dph but not in Area X or HVC. Our results suggest that local regulation of TH signaling is an important factor in the development of the song control nuclei during the song learning phase and that TH activation by DIO2 is a key player in this process. [less ▲]

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See detailEnhanced silicate weathering of tropical shelf sediments exposed during glacial lowstands: a sink for atmospheric CO2
Wan, Shiming; Clift, Peter D.; Zhao, Debo et al

in Geochimica et Cosmochimica Acta (2017), 200

Atmospheric CO2 and global climate are closely coupled. Since 800 ka CO2 concentrations have been up to 50% higher during interglacial compared to glacial periods. Because of its dependence on temperature ... [more ▼]

Atmospheric CO2 and global climate are closely coupled. Since 800 ka CO2 concentrations have been up to 50% higher during interglacial compared to glacial periods. Because of its dependence on temperature, humidity, and erosion rates, chemical weathering of exposed silicate minerals was suggested to have dampened these cyclic variations of atmospheric composition. Cooler and drier conditions and lower non-glacial erosion rates suppressed in situ chemical weathering rates during glacial periods. However, using systematic variations in major element geochemistry, Sr-Nd isotopes and clay mineral records from Ocean Drilling Program Sites 1143 and 1144 in the South China Sea spanning the last 1.1 Ma, we show that sediment deposited during glacial periods was more weathered than sediment delivered during interglacials. We attribute this to subaerial exposure and weathering of unconsolidated shelf sediments during glacial sealevel lowstands. Our estimates suggest that enhanced silicate weathering of tropical shelf sediments exposed during glacial lowstands can account for ~9% of the carbon dioxide removed from the atmosphere during the glacial and thus represent a significant part of the observed glacial-interglacial variation of ~80 ppmv. As a result, if similar magnitudes can be identified in other tropical shelf-slope systems, the effects of increased sediment exposure and subsequent silicate weathering during lowstands could have potentially enhanced the drawdown of atmospheric CO2 during cold stages of the Quaternary. This in turn would have caused an intensification of glacial cycles. We attribute this to subaerial exposure and weathering of unconsolidated shelf sediments during glacial sealevel lowstands. Our estimates suggest that enhanced silicate weathering of tropical shelf sediments exposed during glacial lowstands can account for ~9% of the carbon dioxide removed from the atmosphere during the glacial and thus represent a significant part of the observed glacial-interglacial variation of ~80 ppmv. As a result, if similar magnitudes can be identified in other tropical shelf-slope systems, the effects of increased sediment exposure and subsequent silicate weathering during lowstands could have potentially enhanced the drawdown of atmospheric CO2 during cold stages of the Quaternary. This in turn would have caused an intensification of glacial cycles. [less ▲]

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See detailIgG4-related disease causing rapid evolution of a severe aortic valvular stenosis
BRULS, Samuel ULg; Courtois, Audrey ULg; DELVENNE, Philippe ULg et al

in The Annals of Thoracic Surgery (2017)

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See detailMiddle Miocene climate and vegetation models and their validation with proxy data
Henrot, Alexandra-Jane ULg; Utescher, Torsten; Erdei, Boglarka et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

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See detailLong-Term Care Insurance and Intra-family Moral Hazard: Fixed vs Proportional Insurance Benefits
Klimaviciute, Justina ULg

in GENEVA Risk & Insurance Review (2017)

Pauly (1990) argues that an explanation for the low long-term care (LTC) insurance demand could be intra-family moral hazard: parents might refuse to buy insurance since it reduces children’s incentives ... [more ▼]

Pauly (1990) argues that an explanation for the low long-term care (LTC) insurance demand could be intra-family moral hazard: parents might refuse to buy insurance since it reduces children’s incentives to provide care. This paper raises and explores the idea that the extent of intra-family moral hazard and non-purchase of LTC insurance might differ when insurance benefits are fixed and when they are proportional to LTC expenditures. It shows that fixed benefits limit and might even eliminate intra-family moral hazard, while the effect of proportional benefits is at best ambiguous. Consequently, non-purchase of insurance is less likely with fixed benefits. [less ▲]

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See detailEmission and oxidation of methane in a meromictic, eutrophic and temperate lake (Dendre, Belgium)
Roland, Fleur ULg; Darchambeau, François ULg; Morana, Cédric ULg et al

in Chemosphere (2017)

We sampled the water column of the Dendre stone pit lake (Belgium) in spring, summer, autumn and winter. Depth profiles of several physico-chemical variables, nutrients, dissolved gases (CO2, CH4, N2O ... [more ▼]

We sampled the water column of the Dendre stone pit lake (Belgium) in spring, summer, autumn and winter. Depth profiles of several physico-chemical variables, nutrients, dissolved gases (CO2, CH4, N2O), sulfate, sulfide, iron and manganese concentrations and d13C-CH4 were determined. We performed incubation experiments to quantify CH4 oxidation rates, with a focus on anaerobic CH4 oxidation (AOM), without and with an inhibitor of sulfate reduction (molybdate). The evolution of nitrate and sulfate concentrations during the incubations was monitored. The water column was anoxic below 20 m throughout the year, and was thermally stratified in summer and autumn. High partial pressure of CO2 and CH4 and high concentrations of ammonium and phosphate were observed in anoxic waters. Important nitrous oxide and nitrate concentration maxima were also observed (up to 440 nmol L- 1 and 80 mmol L -1, respectively). Vertical profiles of d13C-CH4 unambiguously showed the occurrence of AOM. Important AOM rates (up to 14 mmol L -1 d- 1) were observed and often co-occurred with nitrate consumption peaks, suggesting the occurrence of AOM coupled with nitrate reduction. AOM coupled with sulfate reduction also occurred, since AOM rates tended to be lower when molybdate was added. CH4 oxidation was mostly aerobic (~80% of total oxidation) in spring and winter, and almost exclusively anaerobic in summer and autumn. Despite important CH4 oxidation rates, the estimated CH4 fluxes from the water surface to the atmosphere were high (mean of 732 mmol m- 2 d- 1 in spring, summer and autumn, and up to 12,482 mmol m- 2 d- 1 in winter). [less ▲]

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See detailHow does forest cover impact water flows and ecosystem services? Insights from real-life catchments in Wallonia (Belgium)
Brogna, Delphine; Vincke, Caroline; Brostaux, Yves ULg et al

in Ecological Indicators (2017), 72

While planet boundaries are being crossed and ecosystems degraded, the Ecosystem Service (ES) conceptrepresents a potential decision-making tool for improved natural resources management. The main aimof ... [more ▼]

While planet boundaries are being crossed and ecosystems degraded, the Ecosystem Service (ES) conceptrepresents a potential decision-making tool for improved natural resources management. The main aimof this paper is to assess the impact of forest cover on water related ES in Wallonia (Belgium) in termsof quantity and timing. We developed an approach based on easily accessible data, monitored in severalcountries and using straightforward statistical methods. This led us to study ES at “real-life” catchmentsscale: 22 catchments – from 30 to 250 km2– with mixed land covers were studied. We approached thewater supply and flood protection services through 5 indicators extracted from 10 hydrological years(2005–2014) discharge data series. These were computed annually and seasonally (vegetation periodfrom March to September and “non-vegetation” period the rest of the year). The water supply wasassessed through the specific volume Vs, the baseflow index BFI and the specific discharge exceeded95% of the time Q95s whereas the flood protection service was approached through the specific dis-charge exceeded 5% of the time Q05s and the flashiness index FI. Our study gives two main insights. First,statistical analyses show that forest cover negatively impact water supply when studying annual and“non-vegetation” period flows in general (Vs) but positively when studying low flows (Q95s). Regardingflood protection a slightly negative impact of forest cover on high flows (Q05s) was highlighted in the“non-vegetation” period. Results also show a negative impact of forests annually and in the vegetationperiod on the flashy behaviour of the catchment thus a positive impact on the flood protection ES. The“year” effect is overall highly significant testifying the importance of climatic factors. Rainfall is oftensignificant and can be considered as a main driver of these ES. Secondly, analyzing the quality of themodels produced and the results overall we assume that other variables characterizing the catchmentssuch as topography or soil types do play a significant role in the delivery of these ES. This questions theuse of land cover proxies in assessing and mapping of hydrological ES at a complex landscape scale. Wethus recommend further research to keep improving land cover proxies if they are used. [less ▲]

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See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

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See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

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See detailExact algorithms for the Equitable Traveling Salesman Problem
Kinable, Joris; Smeulders, Bart ULg; Delcour, Eline et al

in European Journal of Operational Research (2017)

Given a weighted graph G = (V,E), the Equitable Traveling Salesman Problem (ETSP) asks for two perfect matchings in G such that (1) the two matchings together form a Hamiltonian cycle in G and (2) the ... [more ▼]

Given a weighted graph G = (V,E), the Equitable Traveling Salesman Problem (ETSP) asks for two perfect matchings in G such that (1) the two matchings together form a Hamiltonian cycle in G and (2) the absolute difference in costs between the two matchings is minimized. The problem is shown to be NP-Hard, even when the graph G is complete. We present two integer programming models to solve the ETSP problem and compare the strength of these formulations. One model is solved through branch-and-cut, whereas the other model is solved through a branch-and-price framework. A simple local search heuristic is also implemented. We conduct computational experiments on different types of instances, often derived from the TSPLib. It turns out that the behavior of the different approaches varies with the type of instances. For small and medium sized instances, branch-and-bound and branch-and-price produce comparable results. However, for larger instances branch-and- bound outperforms branch-and-price. [less ▲]

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See detailHigh resolution (1 km) positive degree-day modelling of Greenland ice sheet surface mass balance, 1870–2012 using reanalysis data
Wilton, D.; Jowett, A.; Hanna, E. et al

in Journal of Glaciology (2017), 63

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature ... [more ▼]

We show results from a positive degree-day (PDD) model of Greenland ice sheet (GrIS) surface mass balance (SMB), 1870–2012, forced with reanalysis data. The model includes an improved daily temperature parameterization as compared with a previous version and is run at 1 km rather than 5 km resolution. The improvements lead overall to higher SMB with the same forcing data. We also compare our model with results from two regional climate models (RCMs). While there is good qualitative agreement between our PDD model and the RCMs, it usually results in lower precipitation and lower runoff but approximately equivalent SMB: mean 1979–2012 SMB (± standard deviation), in Gt a−1, is 382 ± 78 in the PDD model, compared with 379 ± 101 and 425 ± 90 for the RCMs. Comparison with in situ SMB observations suggests that the RCMs may be more accurate than PDD at local level, in some areas, although the latter generally compares well. Dividing the GrIS into seven drainage basins we show that SMB has decreased sharply in all regions since 2000. Finally we show correlation between runoff close to two calving glaciers and either calving front retreat or calving flux, this being most noticeable from the mid-1990s. [less ▲]

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See detailP-301 High Concentration Multistrain Probiotic Produced at Different Manufacturing Sites: Comparative Analysis.
Lombardi, Francesca; La Torre, Cristina; Giusti, Ilaria et al

in Inflammatory Bowel Diseases (2017), 23

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See detailKey impact of an uncommon plasmid on bacillus amyloliquefaciens subsp. plantarum S499 developmental traits and lipopeptide production
Molinatto, G.; Franzil, L.; Steels, Sébastien ULg et al

in Frontiers in Microbiology (2017), 8(JAN),

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant ... [more ▼]

The rhizobacterium Bacillus amyloliquefaciens subsp. plantarum S499 (S499) is particularly efficient in terms of the production of cyclic lipopeptides, which are responsible for the high level of plant disease protection provided by this strain. Sequencing of the S499 genome has highlighted genetic differences and similarities with the closely related rhizobacterium B. amyloliquefaciens subsp. plantarum FZB42 (FZB42). More specifically, a rare 8008 bp plasmid (pS499) harboring a rap-phr cassette constitutes a major distinctive element between S499 and FZB42. By curing this plasmid, we demonstrated that its presence is crucial for preserving the typical physiology of S499 cells. Indeed, the growth rate and extracellular proteolytic activity were significantly affected in the cured strain (S499 P-). Furthermore, pS499 made a significant contribution to the regulation of cyclic lipopeptide production. Surfactins and fengycins were produced in higher quantities by S499 P-, whereas lower amounts of iturins were detected. In line with the increase in surfactin release, bacterial motility improved after curing, whereas the ability to form biofilm was reduced in vitro. The antagonistic effect against phytopathogenic fungi was also limited for S499 P-, most probably due to the reduction of iturin production. With the exception of this last aspect, S499 P- behavior fell between that of S499 and FZB42, suggesting a role for the plasmid in shaping some of the phenotypic differences observed in the two strains. © 2017 Molinatto, Franzil, Steels, Puopolo, Pertot and Ongena. [less ▲]

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See detailEuropean Network for Neglected Vectors and Vector-Borne Infections COST Action Guidelines: What Is This About and What Is This For?
Charrel, Remi N.; Lempereur, Laetitia ULg; Mihalca, Andrei D. et al

in Vector borne and zoonotic diseases (Larchmont, N.Y.) (2017), 17(1), 1

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See detailAntiplasmodial activity of Heinsia crinita (Rubiaceae) and identification of new iridoids.
Tshisekedi Tshibangu, P.; Mutwale Kapepula, P.; Kabongo Kapinga, M. J. et al

in Journal of Ethnopharmacology (2017), 196

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in ... [more ▼]

ETHNOPHARMACOLOGICAL RELEVANCE: Heinsia crinita is used in traditional medicine for the treatment of febrile illness and erectile dysfunction. Its stem bark powder is found in some peripheral markets in the Democratic Republic of the Congo (DRC) as a remedy against malaria. Investigations were conducted on crude extracts of leaves, fruits and stem barks in view to validate their use and to determine which plant part possesses the best antiplasmodial properties. MATERIALS AND METHODS: Different plant parts were extracted with methanol, ethanol and dichloromethane. Based on the preliminary assays, the dichloromethane extract of the stem bark was subjected to fractionation using preparative HPLC system and column chromatography. This step led to the isolation of two new iridoids which had their structures elucidated by NMR, UV, MS and FT-IR spectroscopic techniques. Extracts and pure compounds were tested in vitro against the 3D7 strain of Plasmodium falciparum. The inhibition of the parasite growth was evaluated in vitro by colorimetric method (p-LDH assay) and their cytotoxicity evaluated in vitro against the human non-cancer fibroblast cell line (WI38) through WST1 assay. The in vivo antiplasmodial activity was assessed by the inhibition of Plasmodium berghei growth in infected mice treated with the ethanol extract of H. crinita stem bark at the concentrations of 200 and 300mg/Kg/day per os, using a protocol based on the 4-d suppressive test of Peters and compared to a non-treated negative control group of mice (growth =100%). Finally the antioxidant activity of the same extract was evaluated using ABTS, DPPH and cell-based assays. RESULTS: A moderate in vitro antiplasmodial activity was observed for the dichloromethane extract of the stem bark of H. crinita (IC50 =29.2+/-1.39microg/mL) and for the two new iridoids, lamalbide 6, 7, 8- triacetate (IC50 =16.39+/-0.43microg/mL) as well as for its aglycone lamiridosin 6, 7, 8-triacetate (IC50 =0.44.56+/-1.12microg/mL). The ethanolic stem bark extract (200 and 300mg/kg/day, oral route) showed a moderate in vivo antimalarial activity in Plasmodium berghei-infected mice with 27.84+/-2.75% and 48.54+/-3.76% of inhibition of the parasite growth, respectively (p<0.01).). This extract displayed high cellular antioxidant activity using dichlorofluorescein-diacetate (DCFDA) on HL-60 monocytes. These crude extracts and pure compounds tested at the higher concentration of 100microg/mL did not show any cytotoxicity against WI38 cells. CONCLUSIONS: The results showed that H. crinita extracts possess antimalarial activity and contain some unusual iridoids with moderate antiplasmodial activity, therefore justifying to some extent its traditional use by the local population in DRC for this purpose. This is the first report of the isolation and antiplasmodial activity of these two new iridoids. [less ▲]

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See detailCombination of Partial Least Squares regression and Design of Experiments to model the retention of pharmaceuticals in Supercritical Fluid Chromatography
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in Journal of Chromatography. A (2017)

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of ... [more ▼]

This work presents a first attempt to establish a model of the retention behaviour for pharmaceutical compounds in gradient mode SFC. For this purpose, multivariate statistics were applied on the basis of data gathered with the Design of Experiment (DoE) methodology. It permitted to build optimally the experiments needed, and served as a basis for providing relevant physicochemical interpretation of the effects observed. Data gathered over a broad experimental domain enabled the establishment of well-fit linear models of the retention of the individual compounds in presence of methanol as co-solvent. These models also allowed the appreciation of the impact of each experimental parameter and their factorial combinations. This approach was carried out with two organic modifiers (i.e. methanol and ethanol) and provided comparable results. Therefore, it demonstrates the feasibility to model retention in gradient mode SFC for individual compounds as a function of the experimental conditions. This approach also permitted to highlight the predominant effect of some parameters (e.g. gradient slope and pressure) on the retention of compounds. Because building of individual models of retention was possible, the next step considered the estab- lishment of a global model of the retention to predict the behaviour of given compounds on the basis of, on the one side, the physicochemical descriptors of the compounds (e.g. Linear Solvation Energy Relationship (LSER) descriptors) and, on the other side, of the experimental conditions. This global model was established by means of partial least squares regression for the selected compounds, in an experimental domain defined by the Design of Experiment (DoE) methodology. Assessment of the model’s predic- tive capabilities revealed satisfactory agreement between predicted and actual retention (i.e. R2 = 0.942, slope = 1.004) of the assessed compounds, which is unprecedented in the field. [less ▲]

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See detailAlcohol-cue exposure decreases response inhibition towards alcohol-related stimuli in detoxified alcohol-dependent patients
Kreusch, Fanny; Billieux, Joël; Quertemont, Etienne ULg

in Psychiatry Research (2017), 249

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol ... [more ▼]

The induction of alcohol craving and the cognitive processing of alcohol-related stimuli in alcohol-dependent patients have been reported to compete with inhibitory control and contribute to alcohol relapse. The aim of the present study is to investigate whether the induction of a craving state, using an alcohol cue exposure paradigm, influences response inhibition towards both neutral stimuli and alcohol-related stimuli in alcohol-dependent patients. Thirty-one detoxified alcohol-dependent patients were exposed to either their preferred alcoholic beverage or to a glass of water. They then performed a modified stop signal task, which used alcohol-related words, neutral words and non-words, and a lexical decision as the Go response. The alcohol-cue exposure group reported significantly higher alcohol craving and showed higher percentages of commission errors towards alcohol-related words than the control group. All participants, but especially those of the alcohol-cue exposure group, showed also shorter reaction times when alcohol words were used as targets in go trials. The induction of alcohol craving in detoxified alcohol-dependent patients increases the motivational salience value of alcohol stimuli, leading them to automatically approach alcohol-related cues and therefore impairing response inhibition towards those stimuli. [less ▲]

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See detailQuantification of Calabrian vegetation in Southern Primory'e (far East of Russia) using multiple proxies
Bondarenko, O. V.; Blokhina, N. I.; Bruch, A. A. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

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See detailProteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma
Herfs, Michael ULg; Longuespée, Rémi ULg; Quick, Charles et al

in Journal of Pathology (The) (2017), 241

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See detailL'intervention de l'assureur dans le procès pénal : la défense de ton assuré tu assumeras ?
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017/1

L'article aborde l'intervention de la compagnie d'assurance dans le procès pénal. Il envisage le contenu de l'article 153 § 5 de la loi du 4 avril 2014 relative aux assurances, les possibilités de défense ... [more ▼]

L'article aborde l'intervention de la compagnie d'assurance dans le procès pénal. Il envisage le contenu de l'article 153 § 5 de la loi du 4 avril 2014 relative aux assurances, les possibilités de défense de l'assureur du prévenu face à la personne lésée et les incidences des moyens et prétentions de l'assureur sur la défense pénale de son assuré prévenu. [less ▲]

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See detailSartre, le XXe siècle
Cormann, Grégory ULg

in Médium (2017), 50

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See detailSeasonal characterization of the nutrients state in Oualidia Lagoon (Moroccan Atlantic coast)
Damsiri, Zainab; Natij, L.; Khalil, Karima et al

in Journal of Materials and Environmental Science (2017), 8(1), 67-77

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at ... [more ▼]

The nutrient cycle in Oualidia lagoon, on the Atlantic Moroccan coast, was studied at both spatial and temporal scales, covering spring and summer conditions. Water samples were collected bimonthly at high tide from March to August during years 2011 and 2012 at six stations distributed throughout the lagoon. The physico- chemistry (temperature, salinity, dissolved O2) and nutrient enrichment of the lagoon surface water were monitored. The average nutrient concentration of surface water were 14.4 μmol.l-1 and 28.1 μmol.l-1 for NH4+, 20.4 μmol.l-1 and 19.9 μmol.l-1 for PO43- and 3.7 μmol.l-1 and 7.6 μmol.l-1 for NO2- in 2011 and 2012, respectively. Strong seasonal differences of nutrient distribution at the different stations were noticed. Temperature, salinity and dissolved O2 were correlated with nutrient concentrations, all parameters showing low spatial (inter-station) variability. Hydrological conditions exert a major control on the nutrient cycling in the lagoon. Results of this study are important to increase the richness on the scientific knowledge of nutrient dynamics along the Moroccan Atlantic coast, particularly in the semi-enclosed lagoons that are important transitional systems. [less ▲]

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See detailTwo new species in the Micarea prasina group from Western Europe
van den Boom, Pieter P. G.; Brand, A. Maarten; Coppins, Brian J. et al

in Lichenologist (2017), 49(1), 13-25

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULg; Dassargues, Alain ULg et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailLegal Mobilization Within the Bureaucracy: Disability Rights and the Implementation of Antidiscrimination Law in Sweden
Lejeune, Aude ULg

in Law and Policy (2017)

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social ... [more ▼]

This paper argues that the analysis of legal mobilization needs to give more attention to the state and its relationship with social movements in order to examine how the state either sustains social movements' demands or is a field of contention for those demands. Focusing on how disability bureaucrats and activists mobilize antidiscrimination law in Sweden, this article shows that two main factors shape legal mobilization within the bureaucracy and alter the state's ability to become a legal mobilization actor: (1) the institutional relationships between social movement organizations and government agencies; and (2) the profiles and careers of bureaucrats and activists. It concludes by suggesting several lines for further research on law and social movements in nonpluralist countries. [less ▲]

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See detailThe frequency and influence of dementia risk factors in prodromal Alzheimer’s disease
Bos, Isabelle; Vos, Stephanie J.; Frölich, Lutz et al

in Neurobiology of Aging (2017)

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association ... [more ▼]

We investigated whether dementia risk factors were associated with prodromal Alzheimer’s disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer’s Association criteria, and with cognitive decline. 1394 subjects from with Mild Cognitive Impairment (MCI) from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of ten risk factors between the subgroups and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared to those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with MCI. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e. preclinical) of AD. [less ▲]

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See detailModeling pre-metastatic lymphvascular niche in the mouse ear sponge assay.
Garcia-Caballero, Melissa; Van De Velde, Maureen ULg; Blacher, Silvia ULg et al

in Scientific Reports (2017), 7

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental for investigating alterations occurring in lymph nodes before tumor cell arrival. In this study, we demonstrate that B16F10 melanoma cell encapsulation in a biomaterial, and implantation in the mouse ear, prevents their rapid lymphatic spread observed when cells are directly injected in the ear. Vascular remodeling in lymph nodes was detected two weeks after sponge implantation, while their colonization by tumor cells occurred two weeks later. In this model, a huge lymphangiogenic response was induced in primary tumors and in pre-metastatic and metastatic lymph nodes. In control lymph nodes, lymphatic vessels were confined to the cortex. In contrast, an enlargement and expansion of lymphatic vessels towards paracortical and medullar areas occurred in pre-metastatic lymph nodes. We designed an original computerized-assisted quantification method to examine the lymphatic vessel structure and the spatial distribution. This new reliable and accurate model is suitable for in vivo studies of lymphangiogenesis, holds promise for unraveling the mechanisms underlying lymphatic metastases and pre-metastatic niche formation in lymph nodes, and will provide new tools for drug testing. [less ▲]

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See detailA new, challenging benchmark for nonlinear system identification
Tiso, Paolo; Noël, Jean-Philippe ULg

in Mechanical Systems & Signal Processing (2017), 84

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by ... [more ▼]

The progress accomplished during the past decade in nonlinear system identi fication in structural dynamics is considerable. The objective of the present paper is to consolidate this progress by challenging the community through a new benchmark structure exhibiting complex nonlinear dynamics. The proposed structure consists of two o ffset cantilevered beams connected by a highly flexible element. For increasing forcing amplitudes, the system sequentially features linear behaviour, localised nonlinearity associated with the buckling of the connecting element, and distributed nonlinearity resulting from large elastic deformations across the structure. A finite element-based code with time integration capabilities is made available at http://sem.org/TDIV-Nonlin.asp. This code permits the numerical simulation of the benchmark dynamics in response to arbitrary excitation signals. [less ▲]

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See detailL’indemnité de procédure, l’appel de la partie civile et l’acquittement du prévenu : la croix et la bannière ?
Michiels, Olivier ULg; Falque, Géraldine ULg

in Revue de Droit Pénal et de Criminologie (2017), 2017/1

En ce qu’il ne permet pas au juge répressif d’accorder au prévenu acquitté et au civilement responsable une indemnité de procédure d’appel à charge de la partie civile succombante qui, en l’absence de ... [more ▼]

En ce qu’il ne permet pas au juge répressif d’accorder au prévenu acquitté et au civilement responsable une indemnité de procédure d’appel à charge de la partie civile succombante qui, en l’absence de tout recours du ministère public, a interjeté appel d’un jugement d’acquittement statuant sur une action intentée par le ministère public, l’article 162bis, alinéa 2, du Code d’instruction criminelle viole les articles 10 et 11 de la Constitution. [less ▲]

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See detailPreparing physically educated citizens in physical education. Expectations and practices
Cloes, Marc ULg

in Retos (2017), 31

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being ... [more ▼]

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being increasingly linked to the promotion of physically active lifestyles. In this paper, we try to determine whether practitioners have the capacity to reach recent objectives for the subject or should reconsider their work on this issue. Moreover, we propose to extend the current focus on physical literacy to encompass the concept of societal transfer, underlining the need for an authentic pedagogy of PE. [less ▲]

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See detailSpecular sets
Berthé, Valérie; De Felice, Clelia; Delecroix, Vincent et al

in Theoretical Computer Science (2017)

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See detailTracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen Streptomyces scabies
Jourdan, Samuel; Francis, Jourdan; Deflandre, Benoit et al

in mSphere (2017)

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See detailSedimentologic and paleoclimatic reconstructions of carbonate factory evolution in the Alborz Basin (northern Iran) indicate a global response to Early Carboniferous (Tournaisian) glaciations
Sardar Abadi, Mehrdad; Kulagina, E.; Voeten, D.F.A.E. et al

in Sedimentary Geology (2017), 348

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See detailEfficient ANOVA for directional data
Ley, Christophe; Swan, Yvik ULg; Verdebout, Thomas

in Annals of the Institute of Statistical Mathematics (2017)

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See detailExploring the Fundamentals of Microreactor Technology with Multidisciplinary Lab Experiments Combining the Synthesis and Characterization of Inorganic Nanoparticles
Emmanuel, Noémie ULg; Emonds-Alt, Gauthier ULg; Lismont, Marjorie et al

in Journal of Chemical Education (2017)

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic ... [more ▼]

Multidisciplinary lab experiments combining microfluidics, nanoparticle synthesis and characterization are presented. These experiments rely on the implementation of affordable yet efficient microfluidic setups based on PFA capillary coils and standard HPLC connectors in upper undergraduate chemistry labs. Fundamental principles and concepts, as well as practical tips for the rapid deployment of microfluidics are presented. In-line membrane separation, segmented-flow regime, high temperature experiments, and in-line analytical techniques are illustrated with the preparation of inorganic nanoparticles (silver, gold, cadmium selenide or telluride) in microreactors. Besides microfluidics, analytical techniques for nanoparticle analysis are also illustrated. [less ▲]

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See detailPolyurethane coatings in 20th century outdoor painted sculptures. Part I: Comparative study of various systems by means of ATR-FTIR spectroscopy
Defeyt, Catherine ULg; Langenbacher, Julia; Rivenc, Rachel

in Heritage Science (2017), 5

Like acrylics and alkyds, polyurethanes (PUs) represent an important class of industrial paints adopted by 20th and 21st artists; primarily by those creating outdoor painted sculptures (OPS). Because PU ... [more ▼]

Like acrylics and alkyds, polyurethanes (PUs) represent an important class of industrial paints adopted by 20th and 21st artists; primarily by those creating outdoor painted sculptures (OPS). Because PU coatings offer a compromise between aesthetic and performance expectations, unachievable with other types of paints, they are commonly recognized as the most appropriate option for painted artworks intended for an outdoor setting. However, the PU class includes various systems and subgroups possessing very different properties. Through the FTIR-ATR study of 137 PU coating references from the Getty Conservation Institute (GCI) reference collection, this paper outlines the differences and the similarities existing, in terms of the composition, of two package solvent-borne, two package water-borne, one package water-borne and fluoropolymer polyurethanes. The comparison of the obtained FTIR-ATR results allowed determining markers helpful to discriminate specific PU subgroups by means of ATR-FTIR spectroscopy. The goals of this paper are to provide to the conservation professionals a better understanding of the versatility and diversity of PU coatings and to facilitate the identification of the various types initially used by the artists. [less ▲]

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See detailA nonlinear state-space approach to hysteresis identification
Noël, Jean-Philippe ULg; Esfahani, Alireza; Kerschen, Gaëtan ULg et al

in Mechanical Systems & Signal Processing (2017), 84

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an ... [more ▼]

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an assumption may be a hard requirement to handle in real applications, since hysteresis is a highly individualistic nonlinear behaviour. The present paper adopts a black-box approach based on nonlinear state-space models to identify hysteresis dynamics. This approach is shown to provide a general framework to hysteresis identification, featuring flexibility and parsimony of representation. Nonlinear model terms are constructed as a multivariate polynomial in the state variables, and parameter estimation is performed by minimising weighted least-squares cost functions. Technical issues, including the selection of the model order and the polynomial degree, are discussed, and model validation is achieved in both broadband and sine conditions. The study is carried out numerically by exploiting synthetic data generated via the Bouc-Wen equations. [less ▲]

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See detailIntermodal network design: a three-mode bi-objective model applied to the case of Belgium
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

in Flexible Services and Manufacturing Journal (2017)

Freight transport planning is nowadays encouraged to align with environmental objectives. Among those, climate change is of particular interest for many countries. In its White Paper on Transport, the ... [more ▼]

Freight transport planning is nowadays encouraged to align with environmental objectives. Among those, climate change is of particular interest for many countries. In its White Paper on Transport, the European Commission considers intermodal transport as a potential solution for reducing environmental impacts. In order to make good strategic transport decisions, realistic decision support models for freight transport networks must be developed, so that insights can be derived for the different stakeholders of the transportation chain. This research proposes a bi-objective mathematical formulation which takes into account economic and environmental objectives, on a road and intermodal network with three modes of transport (road, intermodal rail, and intermodal inland waterways), and in which economies of scale of intermodal transport can be considered. With this model better fitting reality, an application to the Belgian case study provides practical information on how flows, terminal types and locations vary depending on the chosen policy, on the integration or not of economies of scale, on costs or emissions modifications and on the number of terminals to locate. Results show that the chosen policy influences the terminal type and the intermodal market share. The study also highlights the interest of intermodal transport on short distances, and the risk of flow exchanges inside the intermodal market share, rather than between road and intermodal transport. [less ▲]

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See detailRange size heritability and diversification patterns in the liverwort genus Radula
Patiño, J.; Wang, J.; Renner, M.A.M. et al

in Molecular Phylogenetics & Evolution (2017), 106

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