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See detailThe year in cardiology 2014: valvular heart disease.
Pierard, Luc ULg; Vahanian, Alec

in European heart journal (2015)

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See detailEfficacy and cost-effectiveness: A study of different treatment approaches in a tertiary pain centre
VANHAUDENHUYSE, Audrey ULg; Gillet, Aline ULg; MALAISE, Nicole ULg et al

in European Journal of Pain (London, England) (2015)

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See detailActive faulting at the western tip of the Gulf of Corinth, Greece, from high-resolution seismic data
Beckers, Arnaud ULg; Hubert, Aurelia ULg; Beck, Christian et al

in Marine Geology (2015)

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to ... [more ▼]

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to 16 mm yr-1 in its westernmost part. Although the rest of the offshore rift has been well studied, the western tip of the rift is still poorly explored. We present an accurate map of submarine faults in this area based on two high-resolution seismic reflection surveys (single channel sparker). In the eastern part of the studied area, the sedimentary infill is affected by the known North Eratini, South Eratini and West Channel faults. Further to the west, the seafloor is mostly flat, and is bounded to the north by the normal, south-dipping, Trizonia fault. To the north, the shallower part of the Gulf shows to the east a diffuse pattern of normal and strike-slip deformation which is replaced to the west by a 7.5 km long SE striking strike-slip fault zone, called the Managouli fault zone. To the westernmost tip of the Gulf, in the Nafpaktos Basin, two fault sets with different strikes are encountered; the one with aNE-SW strike exhibits a clear strike-slip component. The western tip of the Gulf of Corinth is the only part of the Corinth Rift where convincing evidence for strike-slip movement has been found. This fault pattern is likely related to the complex deformation occurring at the diffuse junction at the western tip of the Rift between three crustal blocks: Continental Greece, Peloponnese, and the Ionian Island-Akarnia block. [less ▲]

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See detailBiogeochemical processes and buffering capacity concurrently affect acidification in a seasonally hypoxic coastal marine basin
Hagens, M.; Slomp, C. P.; Meysman, F. J. R. et al

in Biogeosciences (2015), 12(5), 1561--1583

Coastal areas are impacted by multiple natural and anthropogenic processes and experience stronger pH fluctuations than the open ocean. These variations can weaken or intensify the ocean acidification ... [more ▼]

Coastal areas are impacted by multiple natural and anthropogenic processes and experience stronger pH fluctuations than the open ocean. These variations can weaken or intensify the ocean acidification signal induced by increasing atmospheric pCO2. The development of eutrophication-induced hypoxia intensifies coastal acidification, since the CO2 produced during respiration decreases the buffering capacity in any hypoxic bottom water. To assess the combined ecosystem impacts of acidification and hypoxia, we quantified the seasonal variation in pH and oxygen dynamics in the water column of a seasonally stratified coastal basin (Lake Grevelingen, the Netherlands). Monthly water-column chemistry measurements were complemented with estimates of primary production and respiration using O2 light–dark incubations, in addition to sediment–water fluxes of dissolved inorganic carbon (DIC) and total alkalinity (TA). The resulting data set was used to set up a proton budget on a seasonal scale. Temperature-induced seasonal stratification combined with a high community respiration was responsible for the depletion of oxygen in the bottom water in summer. The surface water showed strong seasonal variation in process rates (primary production, CO2 air–sea exchange), but relatively small seasonal pH fluctuations (0.46 units on the total hydrogen ion scale). In contrast, the bottom water showed less seasonality in biogeochemical rates (respiration, sediment–water exchange), but stronger pH fluctuations (0.60 units). This marked difference in pH dynamics could be attributed to a substantial reduction in the acid–base buffering capacity of the hypoxic bottom water in the summer period. Our results highlight the importance of acid–base buffering in the pH dynamics of coastal systems and illustrate the increasing vulnerability of hypoxic, CO2-rich waters to any acidifying process. [less ▲]

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See detailQu'est-ce qu'un thème?
Badir, Sémir ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2015), 5 (2014)

We approach the notion of theme as a problematic one. Particularly, one can observe that the functions of a theme, as they are assigned by the specialists, especially in linguistics and literary studies ... [more ▼]

We approach the notion of theme as a problematic one. Particularly, one can observe that the functions of a theme, as they are assigned by the specialists, especially in linguistics and literary studies, are multiple and mutually incompatible. It is from this variety reluctant to the disciplinarized modes of knowledge that we have in mind to establish the semiological nature of the theme. Its development is a knowledge that does not bend nor to analysis neither to synthesis. In this research, the lectures made by Roland Barthes at the Collège de France serve as a guide and as an example. [less ▲]

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See detailRethinking Vulnerability Analysis and Governance with Emphasis on a Participatory Approach
Rossignol, Nicolas ULg; Delvenne, Pierre ULg; Turcanu, Catrinel

in Risk Analysis : An Official Publication of the Society for Risk Analysis (2015), 35(1), 129-141

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An ... [more ▼]

This paper draws on vulnerability analysis as it emerged as a complement to classical risk analysis, and it aims at exploring its ability of nurturing risk and vulnerability governance actions. An analysis of the literature on vulnerability analysis allows us to formulate a threefold critique: first, vulnerability analysis has been treated separately in the natural and the technological hazards fields. This separation prevents vulnerability to unleash the full range of its potential, as it constraints appraisals into artificial categories and thus already closes down the outcomes of the analysis. Second, vulnerability analysis focused on assessment tools that are mainly quantitative, whereas qualitative appraisal is a key to assessing vulnerability in a comprehensive way and to informing policy-making. Third, a systematic literature review of case studies reporting on participatory approaches to vulnerability analysis allows us to argue that participation has been important to address the above, but it remains too closed down in its approach and would benefit from embracing a more open, encompassing perspective. Therefore, we suggest rethinking vulnerability analysis as one part of a dynamic process between opening-up and closing-down strategies, in order to support a vulnerability governance framework. [less ▲]

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See detailElevated heart rate at 24-36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure.
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailFe–Ti–V–P ore deposits associated with Proterozoic massif-type anorthosites and related rocks
Charlier, Bernard ULg; Namur, Olivier; Bolle, Olivier ULg et al

in Earth-Science Reviews (2015), 141(0), 56-81

Magmatic rocks containing economic concentrations of iron, titanium, vanadium and phosphorous are commonly associated with massif-type anorthosites and related rocks. This rock association is part of the ... [more ▼]

Magmatic rocks containing economic concentrations of iron, titanium, vanadium and phosphorous are commonly associated with massif-type anorthosites and related rocks. This rock association is part of the anorthosite–mangerite–charnockite–(rapakivi-)granite suites that are restricted to the Proterozoic. Understanding the geochemistry and emplacement mechanisms of ilmenite, magnetite and apatite ore deposits is crucial for exploration, efficient mining operations and ore processing. This review discusses the controlling factors on the grade of an ore, its mineralogy, and its major and trace element distribution. We present petrogenetic models of currently mined deposits (Lac Tio, Tellnes, Damiao) and discuss the characteristics of minor ore bodies from anorthosite provinces worldwide (Grenville, North China Craton, East European Craton, Rogaland, Laramie). Models of formation of anorthosite and related rocks are presented, as well as the nature of the possible parental magmas of the suite. A mineralogical classification of Fe–Ti ores is proposed: (1) Gabbro-noritic ilmenite ore ± apatite ± magnetite; (2) Ti-magnetite-dominated ore; (3) Nelsonite (Fe–Ti oxides + apatite); and (4) Rutile-ilmenite ore. The stability of ilmenite and magnetite is then critically reviewed and the influence of various factors, particularly oxygen fugacity and crystallization pressure, is examined. We discuss liquidus compositions of Fe–Ti oxides and the behavior of important trace elements such as Cr and V, both of which are sensitive to fO2 variations. Post-cumulus evolution of both oxides can occur due to re-equilibration with trapped liquid, re-equilibration with ferromagnesian silicates, exsolution, oxidation, reaction between ilmenite and magnetite, and metamorphic overprinting. These various processes are described and their effects on the oxide geochemistry are emphasized. Several potential ore-forming processes have been invoked and can explain the formation of huge concentration of ilmenite, ± magnetite, ± apatite. Fractional crystallization can be combined with crystal sorting and plagioclase buoyancy to produce relative enrichment of dense ore minerals. Silicate liquid immiscibility can segregate conjugate Si-rich and Fe-rich melts, the latter being enriched in Fe–Ti–P. Magma mixing can produce hybrid magmas located in a single-phase field of the phase diagram and precipitate a pure ilmenite cumulate. Alternative processes are also described, such as ejection of Fe–Ti-enriched residual melts by filter-pressing and compaction, solid-state remobilization of ilmenite in veins, and hydrothermal transport of Fe and Ti from the host anorthosite followed by concentration in veins and lenticular ore bodies. The magnetic properties of Fe–Ti ore deposits present contrasting signatures, depending on whether the natural remanent magnetization is dominated by hemo-ilmenite or multi-domain magnetite. Micro- and macro-scale deformation features of ore rocks are intimately correlated with magma emplacement, and with ballooning of the anorthosite diapir associated with gravitational sagging of dense ore bodies. Exploration perspectives show that oxide-apatite gabbronorites are interesting targets because ilmenite in these rocks is poorer in Cr and Mg, and because the Ti-resource may be combined with apatite and vanadiferous magnetite. [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (2015), 25(1), 20-25

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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See detailInscriptiones Lesbi, Tenedi, Nesi. Concordance des éditions
Famerie, Etienne ULg

in Horos (2015), 26-29

Concordance of the whole corpus of inscriptions of Lesbus, in relation with the inventory of the collection stored in the Archaeological Museum (Lesbus)

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See detailRituximab therapy for hairy cell leukemia : a retrospective study of 41 cases
Leclerc, Mathieu; Suarez, Felipe; Noël, Marie-Pierre et al

in Annals of Hematology (2015), 94

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and ... [more ▼]

The purine analogs (PAs) cladribine and pentostatin have transformed the prognosis of hairy cell leukemia (HCL). However, some patients still relapse after PAs, or fail to reach an optimal response, and new agents are needed to further improve treatment outcome. We retrospectively studied 41 HCL patients from 10 centers in France and Belgium, who received 49 treatment courses with the anti-CD20 monoclonal antibody rituximab. Most of the patients were treated at relapse (84 % of cases) and rituximab was combined to a PA in 41 % of cases. Overall, response rate is 90 % including 71 % complete hematologic responses (CHRs). Frontline treatment, combination therapy, and absolute neutrophil count were associated with response in multivariate analysis. Three-year relapse-free and overall survivals are 68 and 90 %, respectively. When combined to a PA, rituximab yields a 100 % response rate, even beyond frontline therapy. In contrast, response rate is only 82 % (59 % CHR) when rituximab is used alone. In this latter setting, relapse rate is 56 % and median time to relapse is 17.5 months. All eight patients who were treated two times with the antibody responded again to retreatment. We confirm the high efficacy of the combination rituximab + PA. However, when rituximab is used as monotherapy, response rate is lower and the high relapse rate is a concern. Prospective clinical trials are needed to confirm the superiority of the combination rituximab + PA over PA alone, both as frontline therapy and at relapse. [less ▲]

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See detailThe Chemical compositions and the Antioxidant and Antimicrobial Activities of the Essential Oil of Rosemary Leaves from Eastern Morocco
Tahri, Mustapha; Imelouane, Bouchra; Amhamdi, Hassan et al

in Journal of Materials and Environmental Science (2015), 6(3), 666-672

The essential oils compositions of Rosmarinus. tournefortii wild plant, Rosmarinus. tournefortii domesticated plant, and Rosmarinus officinalis.L wild plant growing in different bio climates from eastern ... [more ▼]

The essential oils compositions of Rosmarinus. tournefortii wild plant, Rosmarinus. tournefortii domesticated plant, and Rosmarinus officinalis.L wild plant growing in different bio climates from eastern Morocco, was determined by GC-FID and GC–MS. Oils were assessed for their antimicrobial and antioxidant activities. A variation of chemical compositions attributed to varieties rather than to bio climates was revealed. α-Pinene (0.637% ; 44.22% ; 5.74%), Camphene (11.62% ; 6.52% ; 2.21%), ß-Pinene (14.72% ; 1.14% ; 3.71%), 1,8-Cineole (10.1% ; not identifying ; 56.51%) and Camphor (39.27% ; 7.64% ; 13.56%) were identified as the main constituents of R. tournefortii wild plant, R. tournefortii domesticated plant, and R. officinalis. L wild plant respectively. This study is based on the determination of the diameter of inhibition to moderate antimicrobial and antioxidant activities of oils revealed to be against eight bacteria tested. This was determined by 1,1-diphenyl-1-picrylhydrazyl (DPPH) assay. The highest antimicrobial and antioxidant activities were found in oils from Rosmarinus. tournefortii domesticated plant. [less ▲]

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See detailInvestigation of the links between mass transfer conditions, dissolved hydrogen concentration and biohydrogen production by the pure strain Clostridium butyricum CWBI1009
Beckers, L.; Masset, J.; Hamilton, C. et al

in Biochemical Engineering Journal (2015), 98

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen ... [more ▼]

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen Potential (BHP) tests and in a 2.5L anaerobic sequenced batch reactor (AnSBR) under different operating conditions regarding liquid-to-gas mass transfer. Through the addition of both stirring up to 400rpm and nitrogen sparging, the yields were enhanced from 1.6 to 3.1molH2molglucose -1 and the maximum hydrogen production rates from 140 to 278mLh-1. These original results were achieved with a pure Clostridium strain. They showed that hydrogen production was improved by a higher liquid-to-gas hydrogen transfer resulting in a lower dissolved hydrogen concentration in the culture medium and therefore in a lower bacterial inhibition. In addition, biohydrogen partitioning between the gas and the liquid phase did not conform to Henry's Law due to critical supersaturation phenomena up to seven-fold higher than the equilibrium conditions. Therefore, dissolved hydrogen concentration should be systematically measured instead of the headspace hydrogen partial pressure. A model was proposed to correlate H2 production yield and rate by the pure C. butyricum strain CWBI1009 with mass transfer coefficient KLa. [less ▲]

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See detailAnalytical Procedure Validation and the Quality by Design Paradigm
Rozet, Eric ULg; Lebrun, Pierre ULg; Michiels, Jean-François et al

in Journal of Biopharmaceutical Statistics (2015), 25

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for ... [more ▼]

Since the adoption of the ICH Q8 document concerning the development of pharmaceutical processes following a quality by design (QbD) approach, there have been many discussions on the opportunity for analytical procedure developments to follow a similar approach. While development and optimization of analytical procedure following QbD principles have been largely discussed and described, the place of analytical procedure validation in this framework has not been clarified. This article aims at showing that analytical procedure validation is fully integrated into the QbD paradigm and is an essential step in developing analytical procedures that are effectively fit for purpose. Adequate statistical methodologies have also their role to play: such as design of experiments, statistical modelling, and probabilistic statements. The outcome of analytical procedure validation is also an analytical procedure design space, and from it, control strategy can be set. [less ▲]

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See detailDevelopment of the Lémann Index to assess digestive tract damage in patients with Crohn's disease
Pariente, B; Mary, JY; Danese, S et al

in Gastroenterology (2015), 148

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See detailA quality by design approach for longitudinal quality attributes
Lebrun, Pierre ULg; Giacoletti, Katherine; Scherder, Tara et al

in Journal of Biopharmaceutical Statistics (2015), 25

The concept of quality by design (QbD) as published in ICH-Q8 is currently one of the most recurrent topics in the pharmaceutical literature. This guideline recommends the use of information and prior ... [more ▼]

The concept of quality by design (QbD) as published in ICH-Q8 is currently one of the most recurrent topics in the pharmaceutical literature. This guideline recommends the use of information and prior knowledge gathered during pharmaceutical development studies to provide a scientific rationale for the manufacturing process of a product and provide guarantee of future quality. This poses several challenges from a statistical standpoint and requires a shift in paradigm from traditional statistical practices. First, to provide “assurance of quality” of future lots implies the need to make predictions regarding the quality given past evidence and data. Second, the quality attributes described in the Q8 guidelines are not always a set of unique, independent measurements. In many cases, these criteria are com- plicated longitudinal data with successive acceptance criteria over a defined period of time. A common example is a dissolution profile for a modified or extended-release solid dosage form that must fall within acceptance limits at several time points. A Bayesian approach for longitudinal data obtained in various conditions of a design of experiment is provided to elegantly address the ICH-Q8 recommendation to provide assurance of quality and derive a scientifically sound design space. [less ▲]

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See detailShort communication: Novel method to predict body weight of primiparous dairy cows throughout the lactation
Vanrobays, Marie-Laure ULg; Vandenplas, Jérémie ULg; Hammami, Hedi ULg et al

in Journal of Dairy Science (2015), 98

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the ... [more ▼]

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the lactation would be useful, e.g., at milk-recording dates allowing feed-intake prediction for advisory purposes. Therefore, a 2-step approach was developed to obtain PBW for each milk-recording date. In the first step, a random-regression test-day model was used with CBW as observations to predict PBW. The second step consisted in changing means and (co)variances of prior distributions for the additive genetic random effects of the test-day model by using priors derived from results of the first step to predict again PBW. A total of 25,061 CBW from 24,919 primiparous Holstein cows were computed using equations from literature. Using CBW as observations, PBW was then predicted over the whole lactation for 232,436 dates corresponding to 207,375 milk-recording dates and 25,061 classification dates. Results showed that using both steps (the 2-step approach) provided more accurate predictions than using only the first step (the one-step approach). Based on the results of this preliminary study, BW of dairy cows could be predicted throughout the lactation using this procedure. These predictions could be useful in milk-recording systems to compute traits of interest (e.g., feed-intake prediction). The developed novel method is also flexible because actual direct measurements of BW can also be used together with CBW, the prediction model being able to accommodate different levels of accuracies of used BW phenotypes. [less ▲]

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See detailVISMODEGIB ET CARCINOMES BASOCELLULAIRES LOCALEMENT AVANCES
LEBAS, Eglantine ULg; RORIVE, Andrée ULg; EL HAYDERI, Lara ULg et al

in Revue Médicale de Liège (2015)

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in ... [more ▼]

Basal cell carcinoma is the most frequent skin cancer. Even though metastases are exceptional, these cancers may be locally highly aggressive. The Hedgehog signaling pathway plays a significant role in the pathogenesis of basal cell carcinoma. Vismodegib is a selective inhibitor of this pathway and may be administered orally. Its main indication is locally advanced basal cell carcinoma, when other therapeutic options have failed or are contra-indicated. Vismodegib can also be used as prophylactic therapy in the Gorlin syndrome or basal cell nevomatosis. Its principal adverse effects are muscle spasms, alopecia and altered taste. They are frequent, but often moderate in intensity; they sometimes restrict continuation of treatment. Two clinical cases are presented, relating the efficacity and tolerance of this new therapeutic option. [less ▲]

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See detailRoasted Sunflower Kernel Paste (Tahini) Stability: Storage Conditions and Particle Size Influence
Muresan, Vlad; Danthine, Sabine ULg; Bolboaca, Sorana D. et al

in Journal of the American Oil Chemists' Society (2015)

Sunflower tahini faces quality problems due to the tendency of oil to exudate, causing accelerated rancidity and low marketability. In this study, the colloidal and oxidative stability of different ... [more ▼]

Sunflower tahini faces quality problems due to the tendency of oil to exudate, causing accelerated rancidity and low marketability. In this study, the colloidal and oxidative stability of different trimodal particle size distributions of sunflower tahini (cumulative volume percentages of small, middle and large class populations of 9.61–16.67, 43.03–55.03 and 47.36–28.3) was evaluated during storage at three different temperatures. Decreasing sample particle size decreased the sunflower tahini colloidal stability. The coarsest prototype, being the most stable tahini in terms of oil separation, was included in the oxidative stability storage test together with a commercial tahini. The peroxide values of the studied sunflower tahini samples increased significantly (p < 0.05) with storage time, irrespective of storage temperature, while the p-anisidine values showed an irregular pattern. Considering 30-meq O2/kg as a PV limit, the commercial tahini showed good oxidative stability as it was under this when stored 3 months at 4 °C, 2 months at room temperature and 1 month a 40 °C. The coarsest tahini sample was under the limit when stored 2 months at 4 °C, 1 month at room temperature and 2 weeks at 40 °C. Particle size was shown to be an essential parameter for controlling sunflower tahini’s overall stability. [less ▲]

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See detailThorough characterization of a Self-Emulsifying Drug Delivery System with Raman hyperspectral imaging: A case study.
Sacre, Pierre-Yves ULg; Netchacovitch, Lauranne ULg; De Bleye, Charlotte ULg et al

in International Journal of Pharmaceutics (2015), 484

Newly developed drugs often have poor bioavailability due to their poor water solubility (BCS class 2 drugs). It is therefore necessary to develop new strategies to enhance their solubility and their ... [more ▼]

Newly developed drugs often have poor bioavailability due to their poor water solubility (BCS class 2 drugs). It is therefore necessary to develop new strategies to enhance their solubility and their activity, among which, Self-Emulsifying Drug Delivery System (SEDDS). The efficacy of the drugs contained in these preparations is mainly affected by the solid state and the particle size of the active pharmaceutical ingredient (API). However, it is quite complex, long and expensive to characterize these parameters with classical techniques such as X-Ray powder diffraction, differential scanning calorimetry or hot stage microscopy. The present article presents, through a case study, the advantages of the Raman hyperspectral imaging in the characterization of such formulations. Indeed, Raman chemical imaging may fully characterize SEDDS with single equipment and operator in a non-destructive way allowing the follow-up of the formulation during stability studies. Raman imaging is therefore a tool of choice in the PAT framework since it increases the knowledge of the formulation and the process. A quantitative multivariate method using Raman hyperspectral imaging to assay the API in the lipid based formulation has been developed and fully validated following the “total error” approach. [less ▲]

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See detailThe neural basis of temporal order processing in past and future thought
D'Argembeau, Arnaud ULg; Jeunehomme, Olivier ULg; Majerus, Steve ULg et al

in Journal of Cognitive Neuroscience (2015), 27

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See detailThe influence of various reef sounds on coral-fish larvae behaviour
Parmentier, Eric ULg; Berten, Laetitia; Rigo, Pierre ULg et al

in Journal of Fish Biology (2015)

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See detailLes supports pour l'étude fournis à l'élève en sciences biologiques sont-ils créateurs d'inégalités? Etude exploratoire de productions de futurs enseignants en Fédération Wallonie-Bruxelles (Belgique)
Poffé, Corentin ULg; Laschet, Mélanie ULg; Hindryckx, Marie-Noëlle ULg

in Spirale : Revue de Recherches en Education (2015), 55

Une revue de la littérature permet d’attribuer à de nombreux facteurs les inégalités dans l’apprentissage. Parmi ceux-ci, nous avons choisi d’analyser, avec le regard du formateur d’enseignants, les ... [more ▼]

Une revue de la littérature permet d’attribuer à de nombreux facteurs les inégalités dans l’apprentissage. Parmi ceux-ci, nous avons choisi d’analyser, avec le regard du formateur d’enseignants, les supports pour l’étude proposés par nos étudiants futurs enseignants aux élèves du secondaire (15 à 18 ans) en vue de l’évaluation, lors des cours de sciences biologiques. Cette « photographie instantanée » des supports pour l’étude nous a fourni un état des lieux qui nous permet d’objectiver nos impressions de formateurs quant au rôle des supports pour l’étude dans la problématique des inégalités scolaires. [less ▲]

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See detailThe range of validity of sorption kinetic models
Douven, Sigrid ULg; Pàez Martinez, Carlos ULg; Gommes, Cédric ULg

in Journal of Colloid & Interface Science (2015), 448

Several hundred papers are published yearly reporting liquid-phase adsorption kinetics data. In general the data is analyzed using a variety of standard models such as the pseudo first- and second-order ... [more ▼]

Several hundred papers are published yearly reporting liquid-phase adsorption kinetics data. In general the data is analyzed using a variety of standard models such as the pseudo first- and second-order models and the Intraparticle-Diffusion model. The validity of these models is often assessed empirically via their ability to fit the data, independently of their physicochemical soundness. The aim of the present paper is to rationalize the analysis of liquid-phase adsorption kinetics data, and to investigate experimental factors that influence the adsorption kinetics, in addition to the characteristics of the adsorbent material itself. For that purpose we use a simple Langmuir adsorption–diffusion model, which enables us to identify three dimensionless numbers that characterize the working regime of any batch adsorption experiment: an adsorption Thiele modulus, a saturation modulus, and a loading modulus. The standard models are found to be particular cases of the general adsorption–diffusion model for specific values of the dimensionless numbers. This provides sound physicochemical criteria for the validity of the models. Based on our modeling, we also propose a general yet simple data analysis procedure to practically estimate the diffusion coefficient in adsorbent pellets starting from adsorption halftimes. [less ▲]

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See detailJean-Marie KAJDANSKI, Pain gris, 2014.
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2015), (1/2015), 13-14

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See detailAllogeneic hematopoietic stem cell transplantation for T-prolymphocytic leukemia: a report from the French society for stem cell transplantation (SFGM-TC)
Guillaume, Thierry; Beguin, Yves ULg; Tabrizi, Reza et al

in European Journal of Haematology (2015), 94

T-prolymphocytic leukemia (T-PLL), a rare aggressive mature T-cell disorder, remains frequently resistant to conventional chemotherapy. Studies have suggested that allogeneic hematopoietic stem cell ... [more ▼]

T-prolymphocytic leukemia (T-PLL), a rare aggressive mature T-cell disorder, remains frequently resistant to conventional chemotherapy. Studies have suggested that allogeneic hematopoietic stem cell transplantation (HSCT) might possibly serve to consolidate the response to initial chemotherapy. The current report summarizes the outcome of 27 T-PLL cases identified in the registry in French Society for stem cell transplantation (SFGM-TC). Prior to HSCT, 14 patients were in complete remission (CR), 10 in partial response, three refractory, or in progression. Following HSCT, 21 patients achieved CR as best response. With a median follow-up for surviving patients of 33 (range, 6–103) months, 10 patients are still alive in continuous CR. Overall survival and progression-free survival estimates at 3 yr were 36% (95% CI: 17–54%) and 26% (95% CI: 14–45%), respectively. The relapse incidence after HSCT was 47% occurring at a median of 11.7 (range, 2–24) months. Overall cumulative incidence of transplant-related mortality was 31% at 3 yr. These results suggest that HSCT may allow long-term survival in patients with T-PLL following induction treatment; however, it is associated with a significant rate of toxicity. [less ▲]

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See detailMutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy.
Simons, Cas; Rash, Lachlan D.; Crawford, Joanna et al

in Nature genetics (2015), 47(1), 73-7

Temple-Baraitser syndrome (TBS) is a multisystem developmental disorder characterized by intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great toe. Here we ... [more ▼]

Temple-Baraitser syndrome (TBS) is a multisystem developmental disorder characterized by intellectual disability, epilepsy, and hypoplasia or aplasia of the nails of the thumb and great toe. Here we report damaging de novo mutations in KCNH1 (encoding a protein called ether a go-go, EAG1 or KV10.1), a voltage-gated potassium channel that is predominantly expressed in the central nervous system (CNS), in six individuals with TBS. Characterization of the mutant channels in both Xenopus laevis oocytes and human HEK293T cells showed a decreased threshold of activation and delayed deactivation, demonstrating that TBS-associated KCNH1 mutations lead to deleterious gain of function. Consistent with this result, we find that two mothers of children with TBS, who have epilepsy but are otherwise healthy, are low-level (10% and 27%) mosaic carriers of pathogenic KCNH1 mutations. Consistent with recent reports, this finding demonstrates that the etiology of many unresolved CNS disorders, including epilepsies, might be explained by pathogenic mosaic mutations. [less ▲]

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See detailThe aerodynamic cost of head morphology in bats: maybe not as bad as it seems
Vanderelst, Dieter; Peremans, Herbert; Abdul Razak, Norizham et al

in PLoS ONE (2015), 10(3), 0118545

At first sight, echolocating bats face a difficult trade-off. As flying animals, they would benefit from a streamlined geometric shape to reduce aerodynamic drag and increase flight efficiency. However ... [more ▼]

At first sight, echolocating bats face a difficult trade-off. As flying animals, they would benefit from a streamlined geometric shape to reduce aerodynamic drag and increase flight efficiency. However, as echolocating animals, their pinnae generate the acoustic cues necessary for navigation and foraging. Moreover, species emitting sound through their nostrils often feature elaborate noseleaves that help in focussing the emitted echolocation pulses. Both pinnae and noseleaves reduce the streamlined character of a bat’s morphology. It is generally assumed that by compromising the streamlined charactered of the geometry, the head morphology generates substantial drag, thereby reducing flight efficiency. In contrast, it has also been suggested that the pinnae of bats generate lift forces counteracting the detrimental effect of the increased drag. However, very little data exist on the aerodynamic properties of bat pinnae and noseleaves. In this work, the aerodynamic forces generated by the heads of seven species of bats, including noseleaved bats, are measured by testing detailed 3D models in a wind tunnel. Models of Myotis daubentonii, Macrophyllum macrophyllum, Micronycteris microtis, Eptesicus fuscus, Rhinolophus formosae, Rhinolophus rouxi and Phyllostomus discolor are tested. The results confirm that non-streamlined facial morphologies yield considerable drag forces but also generate substantial lift. The net effect is a slight increase in the lift-to-drag ratio. Therefore, there is no evidence of high aerodynamic costs associated with the morphology of bat heads [less ▲]

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See detailAnti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease.
Esser, Nathalie ULg; Paquot, Nicolas ULg; Scheen, André ULg

in Expert opinion on investigational drugs (2015), 24(3), 283-307

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and cardiovascular disease ... [more ▼]

Introduction: There is a growing body of evidence to suggest that chronic silent inflammation is a key feature in abdominal obesity, metabolic syndrome, type 2 diabetes (T2DM) and cardiovascular disease (CVD). These observations suggest that pharmacological strategies, which reduce inflammation, may be therapeutically useful in treating obesity, type 2 diabetes and associated CVD. Area covered: The article covers novel strategies, using either small molecules or monoclonal antibodies. These strategies include: approaches targeting IKK-b-NF-kB (salicylates, salsalate), TNF-alpha (etanercept, infliximab, adalimumab), IL-1beta (anakinra, canakinumab) and IL-6 (tocilizumab), AMP-activated protein kinase activators, sirtuin-1 activators, mammalian target of rapamycin inhibitors and C-C motif chemokine receptor 2 antagonists. Expert opinion: The available data supports the concept that targeting inflammation improves insulin sensitivity and beta-cell function; it also ameliorates glucose control in insulin-resistant patients with inflammatory rheumatoid diseases as well in patients with metabolic syndrome or T2DM. Although promising, the observed metabolic effects remain rather modest in most clinical trials. The potential use of combined anti-inflammatory agents targeting both insulin resistance and insulin secretion appears appealing but remains unexplored. Large-scale prospective clinical trials are underway to investigate the safety and efficacy of different anti-inflammatory drugs. Further evidence is needed to support the concept that targeting inflammation pathways may represent a valuable option to tackle the cardiometabolic complications of obesity. [less ▲]

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See detailAlgebrability and nowhere Gevrey differentiability
Bastin, Françoise ULg; Conejero, J. Alberto; Esser, Céline ULg et al

in Israel Journal of Mathematics (2015), 205

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and ... [more ▼]

We show that there exist c-generated algebras (and dense in C^infty([0,1])) every nonzero element of which is a nowhere Gevrey diff erentiable function. This leads to results of dense algebrability (and, therefore, lineability) of functions enjoying this property. In the process of proving these results we also provide a new construction of nowhere Gevrey di fferentiable functions. [less ▲]

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See detailThe Innate Immune Response of Equine Bronchial Epithelial Cells is Altered by Training
Frellstedt, Linda ULg; Gosset, Philippe; Kervoaze, Gwenola et al

in Veterinary Research (2015), 46(3), 1-12

Respiratory diseases, including inflammatory airway disease (IAD), viral and bacterial infections, are common problems in exercising horses. The airway epithelium constitutes a major physical barrier ... [more ▼]

Respiratory diseases, including inflammatory airway disease (IAD), viral and bacterial infections, are common problems in exercising horses. The airway epithelium constitutes a major physical barrier against airborne infections and plays an essential role in the lung innate immune response mainly through toll-like receptor (TLR) activation. The aim of this study was to develop a model for the culture of equine bronchial epithelial cells (EBEC) in vitro and to explore EBEC innate immune responses in trained horses. Bronchial epithelial biopsies were taken from 6 adult horses during lower airway endoscopy. EBEC were grown in vitro by an explant method. The innate immune response of EBEC was evaluated in vitro by treatment with TLR ligands. TLR3 is the most strongly expressed TLR at the mRNA level in EBEC and stimulation of EBEC with Poly(I:C), an analog of viral dsRNA, triggers a strong secretion of IFN-β, TNF-α, IL-6 and CXCL8. We further evaluated the EBEC innate immune response in horses that underwent a 4-month-training program. While training had no effect on TLR mRNA expression in EBEC as well as in bronchial biopsies, it increased the production of IFN-β after stimulation with a TLR3 ligand and decreased the secretion of TNF-α and IL-6 after stimulation with a TLR2 and TLR3 ligand. These findings may be implicated in the increased risk for viral and bacterial infections observed in sport horses. Altogether, we report a successful model for the culture of EBEC that can be applied to the investigation of pathophysiologic conditions in longitudinal studies. [less ▲]

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See detailTest-positive rate at CT colonography is increased by rectal bleeding and/orunexplained weight loss, unlike other common gastrointestinal symptoms
Hock, Danielle; MATERNE, Roland; Ouhadi, Roxanne et al

in European Journal of Radiology (2015), 2

2015AbstractPurpose: We evaluated the rate of significant colonic and extra-colonic abnormalities at computed tomography colonography (CTC), accordingto symptoms and age.Materials and methods: We ... [more ▼]

2015AbstractPurpose: We evaluated the rate of significant colonic and extra-colonic abnormalities at computed tomography colonography (CTC), accordingto symptoms and age.Materials and methods: We retrospectively evaluated 7361 consecutive average-risk subjects (3073 males, average age: 60.3 ± 13.9; range 18–96years) for colorectal cancer (CRC) who underwent CTC. They were divided into three groups according to clinical symptoms: 1343 asymptomaticindividuals (group A), 899 patients with at least one “alarm” symptom for CRC, including rectal bleeding and unexplained weight loss (groupC), and 5119 subjects with other gastrointestinal symptoms (group B). Diagnostic and test-positive rates of CTC were established using opticalcolonoscopy (OC) and/or surgery as reference standard. In addition, clinically significant extra-colonic findings were noted.Results: 903 out of 7361 (12%, 95% confidence interval (CI) 0.11–0.13) subjects had at least one clinically significant colonic finding at CTC. CTCtrue positive fraction and false positive fraction were respectively 637/642 (99.2%, 95%CI 0.98–0.99) and 55/692 (7.95%, 95%CI 0.05–0.09). Thepooled test-positive rate in group C (138/689, 20.0%, 95%CI 0.17–0.23) was significantly higher than in both groups A (79/1343, 5.9%, 95%CI0.04–0.07) and B (420/5329, 7.5%, 95%CI 0.07–0.08) (p < 0.001). Aging and male gender were associated to a higher test positive rate. The rateof clinically significant extra-colonic findings was significantly higher in group C (44/689, 6.4%, 95%CI 0.04–0.08) versus groups A (26/1343,1.9%, 95%CI 0.01–0.02) and B (64/5329, 1.2%, 95%CI 0.01–0.02) (p < 0.001).Conclusion: Both test-positive and significant extra-colonic finding rates at CTC are significantly increased in the presence of “alarm” gastroin-testinal symptoms especially in older patients. [less ▲]

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See detailTowards a full integration of optimization and validation phases: An Analytical-Quality-by-Design approach
Hubert, Cédric ULg; Houari, Sabah ULg; Rozet, Eric ULg et al

in Journal of Chromatography. A (2015)

When using an analytical method, defining an Analytical Target Profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process. In this context ... [more ▼]

When using an analytical method, defining an Analytical Target Profile (ATP) focused on quantitative performance represents a key input, and this will drive the method development process. In this context, two case studies were selected in order to demonstrate the potential of a Quality-by-Design (QbD) strategy when applied to two specific phases of the method lifecycle: the pre-validation study and the validation step. The first case study focused on the improvement of a Liquid Chromatography (LC) coupled to Mass Spectrometry (MS) stability-indicating method by the means of the QbD concept. The Design of Experiments (DoE) conducted during the optimization step (i.e. determination of the qualitative Design Space (DS)) was performed a posteriori. Additional experiments were performed in order to simultaneously conduct the pre-validation study to assist in defining the DoE to be conducted during the formal validation step. This predicted protocol was compared to the one used during the formal validation. A second case study based on the LC/MS-MS determination of glucosamine and galactosamine in human plasma was considered in order to illustrate an innovative strategy allowing the QbD methodology to be incorporated during the validation phase. An operational space, defined by the qualitative DS, was considered during the validation process rather than a specific set of working conditions as conventionally performed. Results of all the validation parameters conventionally studied were compared to those obtained with this innovative approach for glucosamine and galactosamine. Using this strategy, qualitative and quantitative information were obtained. Consequently, an analyst using this approach would be able to select with great confidence several working conditions within the operational space rather than a given condition for the routine use of the method. This innovative strategy combines both a learning process and a thorough assessment of the risk involved. [less ▲]

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See detailEditorial. Un regard pluriel sur l’évaluation offert aux scientifiques francophones et construit par eux
Demeuse, Marc; Fagnant, Annick ULg; Dupriez, Vincent

in Evaluer. Journal international de recherche en éducation et formation (2015), 1(1), 5-10

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See detailPhenotype Classification of Zebrafish Embryos by Supervised Learning
Jeanray, Nathalie ULg; Marée, Raphaël ULg; Pruvot, Benoist et al

in PLoS ONE (2015), 10(1), 01169891-20

Zebrafish is increasingly used to assess biological properties of chemical substances and thus is becoming a specific tool for toxicological and pharmacological studies. The effects of chemical substances ... [more ▼]

Zebrafish is increasingly used to assess biological properties of chemical substances and thus is becoming a specific tool for toxicological and pharmacological studies. The effects of chemical substances on embryo survival and development are generally evaluated manually through microscopic observation by an expert and documented by several typical photographs. Here, we present a methodology to automatically classify brightfield images of wildtype zebrafish embryos according to their defects by using an image analysis approach based on supervised machine learning. We show that, compared to manual classification, automatic classification results in 90 to 100 % agreement with consensus voting of biological experts in nine out of eleven considered defects in 3 days old zebrafish larvae. Automation of the analysis and classification of zebrafish embryo pictures reduces the workload and time required for the biological expert and increases the reproducibility and objectivity of this classification. [less ▲]

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See detailUsing local second gradient model and shear strain localisation to model the excavation damaged zone in unsaturated claystone
Pardoen, Benoît ULg; Levasseur, Séverine ULg; Collin, Frédéric ULg

in Rock Mechanics & Rock Engineering (2015), 48(2), 691-714

The drilling of galleries induces damage propagation in the surrounding medium and creates, around them, the excavation damaged zone (EDZ). The prediction of the extension and fracture structure of this ... [more ▼]

The drilling of galleries induces damage propagation in the surrounding medium and creates, around them, the excavation damaged zone (EDZ). The prediction of the extension and fracture structure of this zone remains a major issue, especially in the context of underground nuclear waste storage. Experimental studies on geomaterials indicate that localised deformation in shear band mode usually appears prior to fractures. Thus, the excavation damaged zone can be modelled by considering the development of shear strain localisation bands. In the classical finite element framework, strain localisation suffers a mesh-dependency problem. Therefore, an enhanced model with a regularisation method is required to correctly model the strain localisation behaviour. Among the existing methods, we choose the coupled local second gradient model. We extend it to unsaturated conditions and we include the solid grain compressibility. Furthermore, air ventilation inside underground galleries engenders a rock– atmosphere interaction that could influence the damaged zone. This interaction has to be investigated in order to predict the damaged zone behaviour. Finally, a hydromechanical modelling of a gallery excavation in claystone is presented and leads to a fairly good representation of the EDZ. The main objectives of this study are to model the fractures by considering shear strain localisation bands, and to investigate if an isotropic model accurately reproduces the in situ measurements. The numerical results provide information about the damaged zone extension, structure and behaviour that are in very good agreement with in situ measurements and observations. For instance, the strain localisation bands that develop in chevron pattern during the excavation and rock desaturation, due to air ventilation, are observed close to the gallery. [less ▲]

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See detailEffects of a high-fibre diet on ammonia and greenhouse gas emissions from gestating sows and fattening pigs
Philippe, François-Xavier ULg; Laitat, Martine ULg; Wavreille, José et al

in Atmospheric Environment (2015), 109

This study aims to measure under barn conditions the emissions of NH3, N2O, CH4 and CO2 associated with gestating sows (trial 1) and fattening pigs (trial 2) fed either a control diet (CTD) based on ... [more ▼]

This study aims to measure under barn conditions the emissions of NH3, N2O, CH4 and CO2 associated with gestating sows (trial 1) and fattening pigs (trial 2) fed either a control diet (CTD) based on cereals or a high-fibre diet (HFD) based on sugar beet pulp (SBP). Three successive batches of 10 Belgian Landrace gestating sows were used for trial 1. Two successive batches of 24 Pi etrain Belgian Landrace fattening pigs were used for trial 2. Animals were kept on slatted floor. The gas emissions were measured by infrared photoacoustic detection and expressed per day and per livestock unit, equals to 500 kg body weight. Similar trends were observed for both animal types. With HFD, the NH3 emissions were reduced (27.2 vs. 36.5 g for the gestating sows, P < 0.001; 23.2 vs. 45.0 g for the fattening pigs, P < 0.001) but the CH4 emissions were increased (41.5 vs. 21.0 g for gestating sows, P < 0.001; 37.9 vs. 27.2 g for fattening pigs, P < 0.001). The fibre content of the diet had not significant impact on N2O emissions (around 1.4 g for gestating sows and 2.1 g for fattening pigs, P > 0.05), and on CO2 emissions (around 6.0 kg for gestating sows and 9.1 kg for fattening pigs, P > 0.05). Most of manure parameters did not statistically differ regarding the treatment. Reproductive performance and body condition of the sows were not affected by the diet. However, growth performance and carcass traits of the HFD-fed fattening pigs were deteriorated compared to CTD. [less ▲]

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See detailPulmonary Hypertension in Valvular Disease: A Comprehensive Review on Pathophysiology to Therapy From the HAVEC Group.
Magne, Julien; Pibarot, Philippe; Sengupta, Partho P. et al

in JACC. Cardiovascular imaging (2015), 8(1), 83-99

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the ... [more ▼]

Pulmonary hypertension (PH) is a classic pathophysiological consequence of left-sided valvular heart disease (VHD). However, as opposed to other forms of PH, there are relatively few published data on the prevalence, impact on outcome, and management of PH with VHD. The objective of this paper is to present a systematic review of PH in patients with VHD. PH is found in 15% to 60% of patients with VHD and is more frequent among symptomatic patients. PH is associated with higher risk of cardiac events under conservative management, during valve replacement or repair procedures, and even following successful corrective procedures. In addition to its usefulness in assessing the presence and severity of VHD, Doppler echocardiography is a key tool in diagnosis of PH and assessment of its repercussion on right ventricular function. Assessment of pulmonary arterial pressure during exercise stress echocardiography may provide additional prognostic information beyond resting evaluation. Cardiac magnetic resonance is also useful for assessing right ventricular geometry and function, which provide additional prognostic information in patients with VHD and PH. [less ▲]

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See detailOptimization of a cheap and residential small-scale production of edible crickets with local by-products as an alternative protein-rich human food source in Ratanakiri Province (Cambodia)
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Nieus, Clément et al

in Journal of the Science of Food and Agriculture (2015)

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may ... [more ▼]

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may represent a sustainable, cost effective and high quality alternative source of protein to traditional livestock. This study aimed to optimise a cheap and residential cricket breeding system based on unused wild resources. The cricket development, Teleogryllus testaceus (Walker), under seven diets composed of taro aerial parts, young cassava leaves, young cashew leaves and brown rice flour (with or without banana slices), versus a traditionally used broiler feed diet was studied. Results - Cricket mortality was low in all diets, except the two cashew-based diets. Total biomass was significantly higher under the broiler feed, in addition to the two diets containing a combination of cassava leaf powder and brown rice. Yet, crickets fed with the taro diet had the highest percentage of protein. Concerning the breeding system cost, units using cassava leaves were the cheapest ones. Conclusion – Diets based of cassava leaves seems to be the most promising ones. Nevertheless, to produce crickets with a high body mass and a high protein level, a new experiment must be realised in which the cassava leaf maturity will be adapted to fit with the cricket growth stage. Moreover, to reduce the cost of the breeding units, handmade local products should be used instead of purchased components. [less ▲]

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See detailLa magie et la sorcellerie des visages comme socle anthropologique de la philosophie sartrienne
Englebert, Jérôme ULg

in Etudes Sartriennes (2015), 17

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à ... [more ▼]

L’« émotion » est la possibilité d’une « anthropologie de la relation ». Énoncer une telle proposition nécessite de définir les deux blocs qu’elle relie. Nous réaliserons cette entreprise en recourant à un troisième axe, intermédiaire : celui du visage ou, plutôt, des visages. La thèse de ce court essai tient à considérer que la phénoménologie sartrienne a déjà réalisé ce travail de fond qui requiert, pour le rendre explicite, articulation simple et ordonnancement. [less ▲]

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See detailOsteoporosis in patients taking selective serotonin reuptake inhibitors: a focus on fracture outcome
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Endocrine (2015), 48(1), 65-68

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of ... [more ▼]

Depression is one of the most important mental health problems and a leading cause of disability. Selective serotonin reuptake inhibitors (SSRIs) are considered as first-line therapy for the treatment of depressive symptoms among older adults because of their presumed favorable adverse effect profile. However, they could have deleterious effects on the bone. Evidence from longitudinal, crosssectional, and prospective cohort studies suggests that the use of antidepressants at therapeutic doses is associated with decreased bone mineral density and increased fracture risk. The association between SSRIs use and fracture risk could potentially differ depending on dose, exposure duration, time of exposure, age, or sex. However, the risk of fracture declined rapidly after discontinuation of use of SSRIs. The evidence now seems sufficient to consider adding SSRIs to the list of medications that contribute to osteoporosis. In practice, assessment of risk factor for osteoporosis or fractures could be made taking into account age, gender, duration, and severity of depression, length of SSRI treatments, and other concurrent risk factors. [less ▲]

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See detailMicrofluidic Enzymatic Biosensing Systems: a Review
Mross, Stefan; Pierrat, Sebastien; Zimmermann, Tom et al

in Biosensors & Bioelectronics (2015), 70

Microfluidic biosensing systems with enzyme-based detection have been extensively studied in the last years owing to features such as high specificity, a broad range of analytes and a high degree of ... [more ▼]

Microfluidic biosensing systems with enzyme-based detection have been extensively studied in the last years owing to features such as high specificity, a broad range of analytes and a high degree of automation. This review gives an overview of the most important factors associated with these systems. In the first part, frequently used immobilization protocols such as physisorption and covalent bonding and detection techniques such as amperometry and fluorescence measurements are discussed with respect to effort, lifetime and measurement range. The Michaelis–Menten model describing the kinetics of enzymatic reactions, the role of redox mediators and the limitations of the linear measurement range of enzymatic sensors are introduced. Several possibilities of extending the linear measurement range in microfluidic systems such as diffusion-limiting membranes and the flow injection setup are presented. Regarding the integration of enzymes into microfluidic systems during the fabrication process, the constraints imposed by the biomolecules due to the limited usage of high temperatures and solvents are addressed. In the second part, the most common forms of enzyme integration into microfluidic systems, i.e. in channels and on electrodes, on microparticles, on paper and thread and as injected enzyme solutions, are reviewed, focusing on fabrication, applications and performance. [less ▲]

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See detailCan meandering flows in shallow rectangular reservoir be modelled with the 2D shallow water equations?
Peltier, Yann ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Journal of Hydraulic Engineering (2015)

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using ... [more ▼]

In this article, the ability of the 2D shallow water equations to model meandering flows in shallow rectangular reservoirs is discussed. Four meandering flows, of various shallowness, were modelled using the academic flow model WOLF 2D, which includes a depth-averaged k- model accounting for the horizontal and vertical turbulent length-scales. The bottom friction was modelled with the Colebrook-White formula and different roughness heights were considered. A Proper Orthogonal Decomposition (POD) was applied to the simulation results to extract the behaviour of the main structures responsible for the meandering flow. The same POD analysis was also performed for the reference experimental flow fields, obtained by Large-Scale Particle Image Velocimetry. The first two POD modes obtained from the numerical simulations assuming a smooth bottom are in good agreement with the experimental modes in terms of energy, as well as temporal and spatial variations, whatever the shallowness. In contrast, the remaining simulated modes are not well rendered. The effect of an increased roughness height in the simulations is finally discussed. It leads to an improved reproduction of the first two modes and of the following modes, except when significant viscous effects govern in the flow. [less ▲]

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See detailChemical characterisation and in vitro assessment of the nutritive value of co-products yield from the corn wet-milling process
Malumba Kamba, Paul ULg; Boudry, Christelle ULg; Roiseux, Olivier et al

in Food Chemistry (2015), 166

The chemical characteristics of co-products recovered during a laboratory-scale wet milling procedure as well as that of whole corn flour were characterised and their digestibility and fermentability ... [more ▼]

The chemical characteristics of co-products recovered during a laboratory-scale wet milling procedure as well as that of whole corn flour were characterised and their digestibility and fermentability value determined using a 2 steps in vitro digestibility and fermentation model of the pig digestive tract. Five co-products differing in their chemical composition were collected and analysed. These co-products differed in their in vitro dry matter Digestibility and in their kinetic of fermentation. High coefficients of digestibility were observed for starchy samples, while low coefficients of digestibility were observed for samples rich in lignocellulosic components. Fermentation patterns of samples analysed were different as well as the profile of volatile fatty acids produced during the fermentation. The production of straight-chain fatty acids produced was significantly correlated with the proportion of starch in the sample, while branched-chain fatty acids were correlated to proteins concentration of samples. [less ▲]

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See detailBehavior of various types of seeds of two species of yams tuber (Dioscorea cayenensis Lam. and Dioscorea rotundata Poir.) in Gabon
Ondo Ovono, Paul; Kevers, Claire ULg; Dommes, Jacques ULg

in International Research Journal of Agricultural Science and Soil Science (2015), 5

Low multiplication ratio of yam and scarcity of planting materials are major constraints militating against sustainable yam production. In order to evaluate the behavior of the four various types of seeds ... [more ▼]

Low multiplication ratio of yam and scarcity of planting materials are major constraints militating against sustainable yam production. In order to evaluate the behavior of the four various types of seeds of two species of yams Dioscorea cayenensis and Dioscorea rotundata, cultivated on the experimental ground of the Higher National Institute of Agronomy and Biotechnology (INSAB), a test was realized in a randomized complete block design with six replications. The samples were cut and three levels of each tuber were used :proximal, medial and distal parts of the tuber. The fragments of tuber and the whole tuber represent the various types of seed used in this work. The results showed significant (P<0.05) differences in number of plants emerged and time of emergence in a mixture of 40% soil and 60% sand three months and half after planting. For all species, the proximal parts sprouted earlier than the medium parts and then the distal parts. The fragmentation of tubers in 3 parts can show the existence of a gradient alone the tuber in its potential for sprouting and growth. There was a highly significant (P<0.05) difference between yield performances after 9 months of culture. This technique improves the production of tubers in both species. [less ▲]

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See detailWhen Children’s Knowledge of Memory Improves Children’s Performance in Memory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2015), 29

One of the strongest hypotheses in the field of metacognition research involves the positive effect of metamemory on memory performance. However, due to the lack of appropriate instruments to appraise ... [more ▼]

One of the strongest hypotheses in the field of metacognition research involves the positive effect of metamemory on memory performance. However, due to the lack of appropriate instruments to appraise knowledge of memory, few studies have examined this effect among children. This study was conducted to create and validate an instrument to assess children’s metamemory knowledge and link this knowledge with their memory performance and strategy use. A sample of 166 children was given a new three-factor metamemory interview, and its psychometric properties were investigated. Regression analyses were carried out to investigate the link between metamemory and memory performance in a subgroup of 128 children from the validation study. Results confirmed the scale’s good psychometric properties and revealed its ability to predict children’s memory performance. However, none of the scale’s factors could predict children’s use of memory strategies. Implications for the study of children’s metamemory development are discussed. [less ▲]

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See detailCombining mesoporosity and Ti-doping in hematite films for water splitting
Toussaint, Caroline ULg; Tran, Hoang Son ULg; Colson, Pierre ULg et al

in Journal of Physical Chemistry C (2015), 119(4), 1642-1650

(Graph Presented). In this study, we report the synthesis of Ti-doped mesoporous hematite films by soft-templating for application as photoanodes in the photoelectrolysis of water (water splitting ... [more ▼]

(Graph Presented). In this study, we report the synthesis of Ti-doped mesoporous hematite films by soft-templating for application as photoanodes in the photoelectrolysis of water (water splitting). Because the activation of the dopant requires a heat treatment at high temperature (≥800°C), it usually results in the collapse of the mesostructure. We have overcome this obstacle by using a temporary SiO2 scaffold to hinder crystallite growth and thereby maintain the mesoporosity. The beneficial effect of the activated dopant has been confirmed by comparing the photocurrent of doped and undoped films treated at different temperatures. The role of the mesostructure was investigated by comparing dense, collapsed, and mesoporous films heated at different temperatures and characterized under front and back illumination. It turns out that the preservation of the mesotructure enables a better penetration of the electrolyte into the film and therefore reduces the distance that the photogenerated holes have to travel to reach the electrolyte. As a result, we found that mesoporous films with dopant activation at 850°C perform better than comparable dense and collapsed films. [less ▲]

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See detailLa copie d’expression écrite en langue étrangère : un support équitable ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Spirale (2015), 55

Summative writing assessment is an evaluative practice that aims, at least theoretically, to inform each student about his performance in that skill at a given time, and to help him to understand his ... [more ▼]

Summative writing assessment is an evaluative practice that aims, at least theoretically, to inform each student about his performance in that skill at a given time, and to help him to understand his errors so that he can make progress in his learning. In this article, we analyse summative writing assessment through various prisms. At the macro level, we discuss the reforms of the education system pertaining to assessment ; at the meso level, we target the assessment tools offered by the same education system, as well as the attention that may or may not be paid to remediation ; at the micro level, we deal with the issue of corrective feedback which students receive on their written production. By crossing these different sources (legal provisions, interviews, surveys, analysis of students’ annotated written production, etc.), we conclude that this practice may present major risks of inequality. [less ▲]

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See detailSpore assemblages from Upper Ordovician and Lowermost Silurian sediments recovered from the Qusaiba-1 shallow core hole, Qasim region, central Saudi Arabia
Wellman, Charles H.; Steemans, Philippe ULg; Miller, M.A.

in Review of Palaeobotany and Palynology (2015), 212

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See detailRestoring testosterone levels by adding dehydroepiandrosterone to a drospirenone containing combined oral contraceptive: II. Clinical effects.
Zimmerman, Y.; Foidart, Jean-Michel ULg; Pintiaux, Axelle ULg et al

in Contraception (2015), 91(2), 134-42

OBJECTIVES: Combined oral contraceptives (COCs) decrease androgen levels, including testosterone (T), which may be associated with sexual dysfunction and mood complaints in some women. We have shown that ... [more ▼]

OBJECTIVES: Combined oral contraceptives (COCs) decrease androgen levels, including testosterone (T), which may be associated with sexual dysfunction and mood complaints in some women. We have shown that 'co-administration' of dehydroepiandrosterone (DHEA) to a drospirenone (DRSP)-containing COC restored total T levels to baseline and free T levels by 47%. Here we describe the effects on sexual function, mood and quality of life of such an intervention. STUDY DESIGN: This was a randomized, double-blind, placebo-controlled study in 99 healthy COC starters. A COC containing 30mcg ethinylestradiol (EE) and 3mg DRSP was used for three cycles, followed by six cycles of the same COC combined with 50mg/day DHEA or placebo. Subjects completed the Moos Menstrual Distress Questionnaire (MDQ), the McCoy Female Sexuality Questionnaire and the short form of the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q). Safety and tolerability, including effects on skin, were evaluated. RESULTS: The addition of DHEA induced small but significant improvements compared to placebo in the MDQ score for autonomic reactions during the menstrual (-2.0 vs. 0.71; p=0.05) and the premenstrual phase (-3.1 vs. 2.9; p=0.01) and for behavior during the intermenstrual phase (-1.4 vs. 3.6; p=0.02). A significant difference was found in the MDQ score for arousal during the premenstrual phase in favor of placebo (-5.0 vs. 1.0; p=0.01). There were no statistically significant differences between groups for the MSFQ and Q-LES-Q scores. DHEA 'co-administration' resulted in an acceptable safety profile. DHEA negated the beneficial effect of the COC on acne according to the subjects' self-assessment. CONCLUSIONS: 'Co-administration' with DHEA did not result in consistent improvements in sexual function, mood and quality of life indicators in women taking EE/DRSP. Retrospectively, the 50 mg dose of DHEA may be too low for this COC. IMPLICATIONS: A well-balanced judgment of the clinical consequences of normalizing androgens during COC use may require complete normalization of free T. [less ▲]

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See detailA generic anisotropic continuum damage model integration scheme adaptable to both ductile damage and biological damage-like situations
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2015), 66

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations ... [more ▼]

This paper aims at presenting a general versatile time integration scheme applicable to anisotropic damage coupled to elastoplasticity, considering any damage rate and isotropic hardening formulations. For this purpose a staggered time integration scheme in a finite strain framework is presented, together with an analytical consistent tangent operator. The only restrictive hypothesis is to work with an undamaged isotropic material, assumed here to follow a J2 plasticity model. The only anisotropy considered is thus a damage-induced anisotropy. The possibility to couple any damage rate law with the present algorithm is illustrated with a classical ductile damage model for aluminium, and a biological damage-like application. The later proposes an original bone remodelling law coupled to trabecular bone plasticity for the simulation of orthodontic tooth movements. All the developments have been considered in the framework of the implicit non-linear finite element code Metafor (developed at the LTAS/MN2L, University of Liège, Belgium - www.metafor.ltas.ulg.ac.be). [less ▲]

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See detailEffects of 2,4-dichlorophenoxyacetic acid combined to 6-Benzylaminopurine on callus induction, total phenolic and ascorbic acid production, and antioxidant activities in leaf tissue cultures of Crataegus azarolus L. var. aronia
Chaabani, Ghaya; Tabart, Jessica; Kevers, Claire ULg et al

in Acta Physiologiae Plantarum (2015), 37

The present research work describes the effects of 2,4-dichlorophenoxyacetic acid (2,4-D)/6-Benzylamino-purine (BAP) ratio on callus induction, total phenols and ascorbic acid production and antioxidant ... [more ▼]

The present research work describes the effects of 2,4-dichlorophenoxyacetic acid (2,4-D)/6-Benzylamino-purine (BAP) ratio on callus induction, total phenols and ascorbic acid production and antioxidant activities in leaf-derived calli of Crataegus azarolus (hawthorn). The supplementation of 1.0 mg/L 2,4-D and 1.0 mg/L BAP to MS medium was found to be the most efficient for callus induction (as percentage and fresh weigh). The results of biochemical analysis showed that the highest total phenols contents were obtained in callus cultured on MS medium supplemented with 2.0 mg/L 2,4-D and 1.0 mg/L BAP (52 ± 0.56 mg GAE/g DM) and were significantly lower than those of intact leaves (76 ± 1.72 mg GAE/g DM). However, the highest ascorbic acid contents were found in callus cultured on MS supplemented with 1.0 mg/L 2,4-D and 0.5 mg/L BAP (0.96 ± 0.13 mg AAE/g DM) and these amounts were statistically similar to those found in leaves tissues (0.74 ± 0.07 mg AAE/g DM). Antioxidant activities of callus extracts were determined using two TEAC assays and results showed that extract of callus cultured on MS medium supplemented with 2.0 mg/L 2,4-D and 1.0 mg/L BAP have the greatest antiradical activities against DPPH (124 ± 2.92 mg TE/g DM) and ABTS (0.19 ± 0.02 mg TE/g DM) compared to the leaves of field-grown plant. Thus, the use of high level of 2,4-D over BAP can be suitable to enhance the quality more than the quantity of bioactive compounds in leaf callus culture of hawthorn. [less ▲]

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See detailA note on weighted likelihood and Jeffreys modal estimation of proficiency levels in polytomous item response models
Magis, David ULg

in Psychometrika (2015), 80

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this ... [more ▼]

Warm (1989) established the equivalence between the so-called Jeffreys modal and the weighted likelihood estimators of proficiency level with some dichotomous item response models. The purpose of this note is to extend this result to polytomous item response models. First, a general condition is derived to ensure the perfect equivalence between these two estimators. Second, it is shown that this condition is fulfilled by two broad classes of polytomous models including, among others, the partial credit, rating scale, graded response and nominal response models. [less ▲]

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See detailVers une généralisation des quartiers durables ? Présentation du référentiel d’aide à la conception et à l’évaluation développé en Wallonie et analyse prospective de douze quartiers.
Marique, Anne-Françoise ULg; Delbar, Caroline; Loiseau, Véronique ULg et al

in Urbia (2015)

Un référentiel a été développé en Wallonie, à la demande du Ministre de l’Environnement, de l’Aménagement du Territoire et de la Mobilité, pour opérationnaliser le concept de « quartier durable » en ... [more ▼]

Un référentiel a été développé en Wallonie, à la demande du Ministre de l’Environnement, de l’Aménagement du Territoire et de la Mobilité, pour opérationnaliser le concept de « quartier durable » en objectivant les critères minimum à respecter pour inscrire un quartier dans une vision transversale de développement durable. Ce référentiel constitue un cadre général qui régira les projets de quartiers durables menés en Wallonie (Belgique). Les 5 thématiques et les 25 critères qui constituent ce référentiel sont présentés. La grille de critères est ensuite appliquée à douze quartiers de façon à identifier les invariants communs aux processus de conception de ces quartiers et les freins à l’intégration des principes transversaux du développement durable dans les opérations de ce type. Si les critères relatifs aux performances énergétiques des bâtiments ont percolé dans un grand nombre de cas, la mixité des logements et leur accessibilité, la mixité sociale et la participation restent peu abordés. Le référentiel est disponible depuis début 2014 pour tous les acteurs de l’architecture et de l’urbanisme. [less ▲]

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See detailCaractérisation de colluvions triasiques utilisés dans l'élaboration d'ustensiles rustiques de cuisson, cas de Talatast (Région de Marrakech, Maroc)
El Boudour El Idrissi, Hicham ULg; Daoudi, Lahcen; Collin, Frédéric ULg et al

in Verres, Céramiques & Composites (2014), 3(2), 18-22

The raw material used in the potter site of Talatast (Morocco) is collected from Triassic colluviums. Our study aims to characterize the mineralogical and geotechnical properties of the local clayey ... [more ▼]

The raw material used in the potter site of Talatast (Morocco) is collected from Triassic colluviums. Our study aims to characterize the mineralogical and geotechnical properties of the local clayey material before and after cooking. Our results confirm that the coarse particle size, the mineralogy of the clay fraction and the rate of fondants are suitable for the cookware material production. Defects encountered during the production are mainly related to the use of traditional ovens. Understanding the origin of the main defects could be helpful to promote the local pottery production. [less ▲]

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See detailMyzus persicae feeding on water stressed Arabidopsis affects the emission profile of plant volatile organic compounds
Truong, Dieu-Hien; Delaplace, Pierre ULg; Brostaux, Yves ULg et al

in Journal of Environment and Ecology (2014), 5(2),

Emissions of volatile organic compounds (VOCs) by water-controlled or water-stressed Arabidopsis thaliana infested or not infested with Myzus persicae were evaluated by headspace solid phase ... [more ▼]

Emissions of volatile organic compounds (VOCs) by water-controlled or water-stressed Arabidopsis thaliana infested or not infested with Myzus persicae were evaluated by headspace solid phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). The infestations were maintained for 0–24 h, 24–48 h, and 48–72 h, and the emission profile for each time period was determined. Under these controlled conditions, the proportion of 4-methylpentyl isothiocyanate and dimethyl disulfide emitted by aphid-infested, water-stressed Arabidopsis was greater than that for aphid-infested water-controlled Arabidopsis over the 48–72 h sampling period. The proportion of terpene emitted by aphid-infested water-stressed plants also significantly increased compared with the other treatments over the three assayed sampling periods. In contrast, the proportion of 2-ethylhexanal (the only detected aldehyde) and ketones for the water-controlled plants generally remained high following aphid infestation. Taken together, these original data ascertain that abiotic factors can greatly interact to biotic stresses to alter the VOC emission profiles of plants. [less ▲]

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See detailCaractéristiques et performances de reproduction du Zebu. Le cas du Niger.
Moussa Garba, Mahamadou; Issa, M; Hanzen, Christian ULg

in Revue Africaine de Santé et de Productions Animales [=RASPA] (2014), 12(3-4), 135-141

This review presents an overview of the physiological and anatomical but also reproductive performance of African zebu characteristics. It is a first step to increase his milk and and meat potential by ... [more ▼]

This review presents an overview of the physiological and anatomical but also reproductive performance of African zebu characteristics. It is a first step to increase his milk and and meat potential by using more intensively artificial insemination (AI). The use of AI depends on the use of hormonal protocols to induce and synchronize oestrus. Actually, pregnancy rates obtained are between 31.4 and 46.6% respectively after use of PGF2a or progestagens. In Niger, the average pregnancy rates after artificial insemination is 29.9%. It is higher after in natural heat (43.4%) than induced heat (25.6%); It is also considerably lower after use of PGF2a (8.4%) than progestogens (23.4 to 39.5%). Improvement requires a better understanding of the effect of dietary factors, livestock or pathological responsible for fertility and fecundity. It is therefore important to continue and intensify field trials on more substantial numbers of animals. [less ▲]

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See detailMinimal anomaly-free chiral fermion sets and gauge coupling unification
Ceboa, Luis; Emmanuel-Costa, David; González Felipe, Ricardo et al

in Physical Review. D, Particles, Fields, Gravitation, and Cosmology (2014)

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study ... [more ▼]

We look for minimal chiral sets of fermions beyond the standard model that are anomaly free and, simultaneously, vectorlike particles with respect to color SU(3) and electromagnetic U(1). We then study whether the addition of such particles to the standard model particle content allows for the unification of gauge couplings at a high energy scale, above 5.0 × 1015 GeV so as to be safely consistent with proton decay bounds. The possibility to have unification at the string scale is also considered. Inspired in grand unified theories, we also search for minimal chiral fermion sets that belong to SU(5) multiplets, restricted to representations up to imension 50. It is shown that, in various cases, it is possible to achieve gauge unification provided that some of the extra fermions decouple at relatively high intermediate scales. [less ▲]

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See detailBacterial Community Composition in Three Freshwater Reservoirs of Different Alkalinity and Trophic Status
Llirós, Marc; Inceoğlu, Özgul; García-Armisen, Tamara et al

in PLoS ONE (2014)

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See detailEarly history of extended irreversible thermodynamics (1953-1983): an exploration beyond local equilibrium and classical transport theory
Lebon, Georgy ULg; Jou, david

in European Physical Journal H. Historical Perspectives on Contemporary Physics (2014), 5(23),

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See detailDetection of response to command using voluntary control of breathing in disorders of consciousness
Charland-Verville, Vanessa ULg; Lesenfants, Damien; Sela, Lee et al

in Frontiers in Human Neuroscience (2014), 8(1020),

BACKGROUND: Detecting signs of consciousness in patients in a vegetative state/unresponsive wakefulness syndrome (UWS/VS) or minimally conscious state (MCS) is known to be very challenging. Plotkin et al ... [more ▼]

BACKGROUND: Detecting signs of consciousness in patients in a vegetative state/unresponsive wakefulness syndrome (UWS/VS) or minimally conscious state (MCS) is known to be very challenging. Plotkin et al. (2010) recently showed the possibility of using a breathing-controlled communication device in patients with locked in syndrome. We here aim to test a breathing-based "sniff controller" that could be used as an alternative diagnostic tool to evaluate response to command in severely brain damaged patients with chronic disorders of consciousness (DOC). METHODS: Twenty-five DOC patients were included. Patients' resting breathing-amplitude was measured during a 5 min resting condition. Next, they were instructed to end the presentation of a music sequence by sniffing vigorously. An automated detection of changes in breathing amplitude (i.e., >1.5 SD of resting) ended the music and hence provided positive feedback to the patient. RESULTS: None of the 11 UWS/VS patients showed a sniff-based response to command. One out of 14 patients with MCS was able to willfully modulate his breathing pattern to answer the command on 16/19 trials (accuracy 84%). Interestingly, this patient failed to show any other motor response to command. DISCUSSION: We here illustrate the possible interest of using breathing-dependent response to command in the detection of residual cognition in patients with DOC after severe brain injury. [less ▲]

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See detailRapid dynamic activation of a marine-based Arctic ice cap
McMillan, M; Shepherd, A; Gourmelen, N et al

in Geophysical Research Letters (2014), 41(24), 89028909

We use satellite observations to document rapid acceleration and ice loss from a formerly slow-flowing, marine-based sector of Austfonna, the largest ice cap in the Eurasian Arctic. During the past two ... [more ▼]

We use satellite observations to document rapid acceleration and ice loss from a formerly slow-flowing, marine-based sector of Austfonna, the largest ice cap in the Eurasian Arctic. During the past two decades, the sector ice discharge has increased 45-fold, the velocity regime has switched from predominantly slow (~ 101 m/yr) to fast (~ 103 m/yr) flow, and rates of ice thinning have exceeded 25 m/yr. At the time of widespread dynamic activation, parts of the terminus may have been near floatation. Subsequently, the imbalance has propagated 50 km inland to within 8 km of the ice cap summit. Our observations demonstrate the ability of slow-flowing ice to mobilize and quickly transmit the dynamic imbalance inland; a process that we show has initiated rapid ice loss to the ocean and redistribution of ice mass to locations more susceptible to melt, yet which remains poorly understood. [less ▲]

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See detailDrivers of inorganic carbon dynamics in first-year sea ice: A model study.
Moreau, Sebastien; Vancoppenolle, Martin; Delille, Bruno ULg et al

in Journal of Geophysical Research. Oceans (2014)

Sea ice is an active source or a sink for carbon dioxide (CO2), although to what extent is not clear. Here, we analyze CO2 dynamics within sea ice using a one-dimensional halo-thermodynamic sea ice model ... [more ▼]

Sea ice is an active source or a sink for carbon dioxide (CO2), although to what extent is not clear. Here, we analyze CO2 dynamics within sea ice using a one-dimensional halo-thermodynamic sea ice model including gas physics and carbon biogeochemistry. The ice-ocean fluxes and vertical transport of total dissolved inorganic carbon (DIC) and total alkalinity (TA) are represented using fluid transport equations. [less ▲]

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See detailLa thermoplastie bronchique dans le traitement de l'asthme sévère de l'adulte.
Chanez, P.; Boulet, L.-P.; Brillet, P.-Y. et al

in Revue des maladies respiratoires (2014)

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since ... [more ▼]

Bronchial thermoplasty is a recent endoscopic technique for the treatment of severe asthma. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based treatment, the evaluation procedure of risks and benefits is different that for pharmaceutical products; safety aspects, regulatory requirements, study design and the assessment of the magnitude of effects may all be different. The mechanism of action and optimal patient selection need to be assessed further in rigorous clinical and scientific studies. This technique is in harmony with the development of personalised medicine in the 21st century. It should be developed further in response to the numerous challenges and needs not yet met in the management of severe asthma. [less ▲]

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See detailEtude des facteurs influençant la visite des oiseaux dans les champs de riz
Nasasagare, Régine-Pacis; Ntakimazi, Gaspard; Libois, Roland ULg

in Bulletin scientifique de l'Institut national pour l'environnement et la conservation de la nature (2014), 13

This study was conducted in order to show pest bird species on rice in Burundi. An exhaustive ornithologic inventory was done in 45 fields in the plain of Rusizi and 30 in Ngozi fields were randomly ... [more ▼]

This study was conducted in order to show pest bird species on rice in Burundi. An exhaustive ornithologic inventory was done in 45 fields in the plain of Rusizi and 30 in Ngozi fields were randomly chosen and classified in 3 categories for Rusizi plain (2 for Ngozi): fully guarded plots, partially guarded plots and not guarded plots. There were no fields partially guarded for Ngozi. Resultats revealed a list of bird species that have a real impact on rice production in Burundi. The current study also allowed to put in evidence factors of the motivation of their visit. [less ▲]

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See detailMapping Gene Regulatory Networks in Drosophila Eye Development by Large-Scale Transcriptome Perturbations and Motif Inference
Potier, Delphine; Davie, Kristofer; Hulselmans, Gert et al

in Cell Reports (2014), 9(6), 2290-2303

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their ... [more ▼]

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their functional targets are represented by gene regulatory networks (GRNs). Deciphering in vivo GRNs underlying organ development in an unbiased genome-wide setting involves identifying both functional TF-gene interactions and physical TF-DNA interactions. To reverse engineer the GRNs of eye development in Drosophila, we performed RNA-seq across 72 genetic perturbations and sorted cell types and inferred a coexpression network. Next, we derived direct TF-DNA interactions using computational motif inference, ultimately connecting 241 TFs to 5,632 direct target genes through 24,926 enhancers. Using this network, we found network motifs, cis-regulatory codes, and regulators of eye development. We validate the predicted target regions of Grainyhead by ChIP-seq and identify this factor as a general cofactor in the eye network, being bound to thousands of nucleosome-free regions. [less ▲]

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See detailCyclovirus CyCV-VN species distribution is not limited to Vietnam and extends to Africa
Garigliany, Mutien-Marie ULg; Hagen, Ralf Mathias; Frickmann, Hagen et al

in Scientific Reports (2014), 4

Cycloviruses, small ssDNA viruses of the Circoviridae family, have been identified in the cerebrospinal fluid from symptomatic human patients. One of these species, cyclovirus-Vietnam (CyCV-VN), was shown ... [more ▼]

Cycloviruses, small ssDNA viruses of the Circoviridae family, have been identified in the cerebrospinal fluid from symptomatic human patients. One of these species, cyclovirus-Vietnam (CyCV-VN), was shown to be restricted to central and southern Vietnam. Here we report the detection of CyCV-VN species in stool samples from pigs and humans from Africa, far beyond their supposed limited geographic distribution. [less ▲]

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See detailFirst Evidence of a Volatile Sex Pheromone in Lady Beetles
Fassotte, Bérénice ULg; Fischer, Christophe ULg; Durieux, Delphine ULg et al

in PLoS ONE (2014)

To date, volatile sex pheromones have not been identified in the Coccinellidae family; yet, various studies have suggested that such semiochemicals exist. Here, we collected volatile chemicals released by ... [more ▼]

To date, volatile sex pheromones have not been identified in the Coccinellidae family; yet, various studies have suggested that such semiochemicals exist. Here, we collected volatile chemicals released by virgin females of the multicolored Asian lady beetle, Harmonia axyridis (Pallas), which were either allowed or not allowed to feed on aphids. Virgin females in the presence of aphids, exhibited “calling behavior”, which is commonly associated with the emission of a sex pheromone in several Coleoptera species. These calling females were found to release a blend of volatile compounds that is involved in the remote attraction (i.e., from a distance) of males. Gas Chromatography-Mass Spectrometry (GC-MS) analyses revealed that (–)-β-caryophyllene was the major constituent of the volatile blend (ranging from 80 to 86%), with four other chemical components also being present; β-elemene, methyl-eugenol, α-humulene, and α-bulnesene. In a second set of experiments, the emission of the five constituents identified from the blend was quantified daily over a 9-day period after exposure to aphids. We found that the quantity of all five chemicals significantly increased across the experimental period. Finally, we evaluated the activity of a synthetic blend of these chemicals by performing bioassays which demonstrated the same attractive effect in males only. The results confirm that female H. axyridis produce a volatile sex pheromone. These findings have potential in the development of more specific and efficient biological pest-control management methods aimed at manipulating the behavior of this invasive lady beetle. [less ▲]

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See detailLa mémoire du génocide des Juifs chez les jeunes. Connaissances, émotions et évaluations
Grandjean, Geoffrey ULg

in Questions de mémoire et de représentation (2014)

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See detailEffets de deux associations culturales à base de blé sur les populations de pucerons (Homoptera: Aphididae) et d’auxiliaires aphidiphages: étude préliminaire menée en Chine
Chevalier Mendes Lopes, Thomas ULg; Bosquée, Emilie ULg; Honba, David et al

in Entomologie Faunistique = Faunistic Entomology (2014), 67

Crop associations have several advantages when plant species and crop production methods, including harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to ... [more ▼]

Crop associations have several advantages when plant species and crop production methods, including harvesting, are well selected. This preliminary study was conducted in the Shandong province (China) to better characterize the effect of wheat (Triticum aestivum L.)/oilseed rape (Brassica napus L.) and wheat/pea (Pisum sativum L.) associations on the aphid and aphidophagous beneficial populations. Aphids observed on wheat tillers were significantly more abundant in the pure stand of wheat during the two weeks prior to their population peak, compared with crop associations. Considering the aphidophagous beneficials, significantly more ladybirds were observed in the associations, compared with the pure stand during their abundance peak. Yellow pan traps were also used to assess the diversity and abundance of adult beneficial species. The parasitoid species Aphidius gifuensis (Ashmead) was prevalent. Among predators, Propylea japonica (Thunberg) and Harmonia axyridis (Pallas) were the most abundant species. This study contributes to better understand the potential of crop associations with wheat as a sustainable method to control aphid populations in this region of China. [less ▲]

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See detailSound production in Onuxodon fowleri (Carapidae) and its amplification by the host shell
Kever, Loïc ULg; Colleye, Orphal ULg; Lugli, Marco et al

in Journal of Experimental Biology (2014), 217

Onuxodon species are well known for living inside pearl oysters. As in other carapids, their anatomy highlights their ability to make sounds but sound production has never been documented in Onuxodon ... [more ▼]

Onuxodon species are well known for living inside pearl oysters. As in other carapids, their anatomy highlights their ability to make sounds but sound production has never been documented in Onuxodon. This paper describes sound production in Onuxodon fowleri as well as the anatomy of the sound production apparatus. Single-pulsed sounds and multiple-pulsed sounds that sometimes last more than 3 s were recorded in the field and in captivity (Makemo Island, French Polynesia). These pulses are characterized by a broadband frequency spectrum from 100 to 1000 Hz. Onuxodon fowleri is mainly characterized by its ability to modulate the pulse period, meaning that this species can produce pulsed sounds and tonal-like sounds using the same mechanism. In addition, the sound can be remarkably amplified by the shell cavity (peak gain can exceed 10 dB for some frequencies). The sonic apparatus of O. fowleri is characterized by a rocker bone in front of the swimbladder, modified vertebrae and epineurals, and two pairs of sonic muscles, one of which (primary sonic muscle) inserts on the rocker bone. The latter structure, which is absent in other carapid genera, appears to be sexually dimorphic suggesting differences in sound production in males and females. Sound production in O. fowleri could be an example of adaptation where an animal exploits features of its environment to enhance communication. [less ▲]

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See detailHepatitis C Virus Life Cycle and Lipid Metabolism
Popescu, Costin-Ioan; Riva, Laura ULg; Vlaicu, Ovidiu et al

in Biology (2014), 3

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See detailDetection of small amounts of human adenoviruses in stools: comparison of a new immuno real-time PCR assay with classical tools.
Bonot, Sebastian; Ogorzaly, Leslie; Elmoualij, Benaïssa ULg et al

in Clinical Microbiology & Infection (2014), 20(12), 1-7

The detection of low virus concentrations in biological matrices, especially stool samples, is facing significant limitations as far as common diagnostic methods (enzyme-linked-immunosorbent assay (ELISA ... [more ▼]

The detection of low virus concentrations in biological matrices, especially stool samples, is facing significant limitations as far as common diagnostic methods (enzyme-linked-immunosorbent assay (ELISA) or quantitative real-time PCR (qPCR)) are considered. Here the development of a new immuno real-time PCR (iPCR) is described and its performance in the detection of human adenoviruses (HAdVs) in spiked stools is compared with those of ELISA and qPCR assays. For the iPCR, detection of the sandwich formed by the complexation of capture antibody-antigen-detection antibody was performed by qPCR thanks to the substitution of peroxydase by a chimeric DNA. This modification increased the detection sensitivity 200-fold compared to ELISA. The direct qPCR results revealed that only 0.3–9.5% of the spiked HAdV were detectable, resulting from important losses of DNA occurring at the extraction step. This step was not necessary in the iPCR workflow, avoiding this drawback. The losses of viral particles occurred at the elution step from the stool only. The recovery rate of the iPCR was thus better and ranged between 21 and 54%. As a result, iPCR enabled the detection of lower virus concentrations in stool samples compared to those detected by ELISA and qPCR. The iPCR could be considered as a ‘hyper sensitive ELISA’ for early detection of HAdV infections, especially in the case of immunocompromised patients after haematopoietic stem cell transplant. [less ▲]

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See detailMeasuring the Effect of Stochastic Perturbation Component in Cellular Automata Urban Growth Model
El Saeid Mustafa, Ahmed Mohamed ULg; Saadi, Ismaïl ULg; Cools, Mario ULg et al

in Procedia Environmental Sciences (2014), 22(Winter), 156168

Urban environments are complex dynamic systems whose prediction of the future states cannot exclusively rely on deterministic rules. Although several studies on urban growth were carried out using ... [more ▼]

Urban environments are complex dynamic systems whose prediction of the future states cannot exclusively rely on deterministic rules. Although several studies on urban growth were carried out using different modelling approaches, the measurement of uncertainties was commonly neglected in these studies. This paper investigates the effect of uncertainty in urban growth models by introducing a stochastic perturbation method. A cellular automaton is used to simulate predicted urban growth. The effect of stochastic perturbation is addressed by comparing series of urban growth simulations based on different degree of stochastic perturbation randomness with the original urban growth simulation, obtained with the sole cellular automata neighbouring effects. These simulations are evaluated using cell-to-cell location agreement and a number of spatial metrics. The model framework has been applied to the Ourthe river basin in Belgium. The results show that the accuracy of the model is increased by introducing a stochastic perturbation component with a limited degree of randomness, in the cellular automata urban growth model. [less ▲]

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See detailRGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification
Huang, Yi-Shiang ULg; Bertrand, Virginie ULg; Bozukova, Dimitriya et al

in PLoS ONE (2014), 9(12), 32

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal ... [more ▼]

Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient’s age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development. [less ▲]

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See detailAssessing spatio-temporal variability and trends in modelled and measured Greenland Ice Sheet albedo (2000–2013)
Alexander, P.; Tedesco, M.; Fettweis, Xavier ULg et al

in Cryosphere (The) (2014), 8

Accurate measurements and simulations of Greenland Ice Sheet (GrIS) surface albedo are essential, given the role of surface albedo in modulating the amount of absorbed solar radiation and meltwater ... [more ▼]

Accurate measurements and simulations of Greenland Ice Sheet (GrIS) surface albedo are essential, given the role of surface albedo in modulating the amount of absorbed solar radiation and meltwater production. In this study, we assess the spatio-temporal variability of GrIS albedo during June, July, and August (JJA) for the period 2000–2013. We use two remote sensing products derived from data collected by the Moderate Resolution Imaging Spectroradiometer (MODIS), as well as outputs from the Modèle Atmosphérique Régionale (MAR) regional climate model (RCM) and data from in situ automatic weather stations. Our results point to an overall consistency in spatio-temporal variability between remote sensing and RCM albedo, but reveal a difference in mean albedo of up to ~0.08 between the two remote sensing products north of 70° N. At low elevations, albedo values simulated by the RCM are positively biased with respect to remote sensing products by up to ~0.1 and exhibit low variability compared with observations. We infer that these differences are the result of a positive bias in simulated bare ice albedo. MODIS albedo, RCM outputs, and in situ observations consistently indicate a decrease in albedo of −0.03 to −0.06 per decade over the period 2003–2013 for the GrIS ablation area. Nevertheless, satellite products show a decline in JJA albedo of −0.03 to −0.04 per decade for regions within the accumulation area that is not confirmed by either the model or in situ observations. These findings appear to contradict a previous study that found an agreement between in situ and MODIS trends for individual months. The results indicate a need for further evaluation of high elevation albedo trends, a reconciliation of MODIS mean albedo at high latitudes, and the importance of accurately simulating bare ice albedo in RCMs. [less ▲]

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See detailReversible cross-linking of aliphatic polyamides bearing thermo- and photoresponsive cinnamoyl moieties
Tunc, Deniz ULg; Le Coz, Cédric; Alexandre, Michaël et al

in Macromolecules (2014), 47(23), 8247-8254

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See detailHigh plasma concentrations of sclerostin, an inhibitor of the Wnt signaling pathway in young horses affected by osteochondrosis
Serteyn, Didier ULg; Mendoza García, Luis ULg; Sandersen, Charlotte ULg et al

in Open journal of orthepedics (2014)

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and ... [more ▼]

Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases. [less ▲]

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See detailConstraining the Exozodiacal Luminosity Function of Main-sequence Stars: Complete Results from the Keck Nuller Mid-infrared Surveys
Mennesson, B.; Millan-Gabet, R.; Serabyn, E. et al

in Astrophysical Journal (2014), 797

Forty-seven nearby main-sequence stars were surveyed with the Keck Interferometer mid-infrared Nulling instrument (KIN) between 2008 and 2011, searching for faint resolved emission from exozodiacal dust ... [more ▼]

Forty-seven nearby main-sequence stars were surveyed with the Keck Interferometer mid-infrared Nulling instrument (KIN) between 2008 and 2011, searching for faint resolved emission from exozodiacal dust. Observations of a subset of the sample have already been reported, focusing essentially on stars with no previously known dust. Here we extend this previous analysis to the whole KIN sample, including 22 more stars with known near- and/or far-infrared excesses. In addition to an analysis similar to that of the first paper of this series, which was restricted to the 8-9 mum spectral region, we present measurements obtained in all 10 spectral channels covering the 8-13 mum instrumental bandwidth. Based on the 8-9 mum data alone, which provide the highest signal-to-noise measurements, only one star shows a large excess imputable to dust emission (eta Crv), while four more show a significant (>3sigma) excess: beta Leo, beta UMa, zeta Lep, and gamma Oph. Overall, excesses detected by KIN are more frequent around A-type stars than later spectral types. A statistical analysis of the measurements further indicates that stars with known far-infrared (lambda >= 70 mum) excesses have higher exozodiacal emission levels than stars with no previous indication of a cold outer disk. This statistical trend is observed regardless of spectral type and points to a dynamical connection between the inner (zodi-like) and outer (Kuiper-Belt-like) dust populations. The measured levels for such stars are clustering close to the KIN detection limit of a few hundred zodis and are indeed consistent with those expected from a populat [less ▲]

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See detailInfluence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils
Huynen, Céline ULg; Willet, Nicolas ULg; Duwez, Anne-Sophie ULg et al

in Biochimica et Biophysica Acta-Proteins and Proteomics (2014)

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See detailFlow Cytometry Assessment of CD34+ Viability in Thawed Cord Blood Units: A Multi-Center Eurocord and Netcord Study
SACCARDI, RICCARDO; AZQUETA, Carmen; BALLERINI, Lara et al

in Blood (2014), 124

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See detailDirect route to well-defined poly(ionic liquid)s by controlled radical polymerization in water
Cordella, Daniela ULg; Kermagoret, Anthony ULg; Debuigne, Antoine ULg et al

in ACS Macro Letters (2014), 3

The precision synthesis of poly(ionic liquid)s (PILs) in water is achieved for the first time by the cobalt-mediated radical polymerization (CMRP) of N-vinyl-3-alkylimidazolium-type monomers following two ... [more ▼]

The precision synthesis of poly(ionic liquid)s (PILs) in water is achieved for the first time by the cobalt-mediated radical polymerization (CMRP) of N-vinyl-3-alkylimidazolium-type monomers following two distinct protocols. The first involves the CMRP of various 1-vinyl-3-alkylimidazolium bromides conducted in water in the presence of an alkyl–cobalt(III) complex acting as a monocomponent initiator and mediating agent. Excellent control over molar mass and dispersity is achieved at 30 °C. Polymerizations are complete in a few hours, and PIL chain-end fidelity is demonstrated up to high monomer conversions. The second route uses the commercially available bis(acetylacetonato)cobalt(II) (Co(acac)2) in conjunction with a simple hydroperoxide initiator (tert-butyl hydroperoxide) at 30, 40, and 50 °C in water, facilitating the scaling-up of the technology. Both routes prove robust and straightforward, opening new perspectives onto the tailored synthesis of PILs under mild experimental conditions in water. [less ▲]

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See detailEnrichment of Logging Gaps with a High Conservation Value Species (Pericopsis elata) in a Central African Moist Forest
Ouedraogo, Dakis-Yaoba ULg; Fayolle, Adeline ULg; Daïnou, Kasso ULg et al

in Forests (2014), 5(12), 3031-3047

In central Africa, most of the timber species require high light at the seedling stage for survival and growth. Forest managers face a regeneration shortage of these light-demanding timber species. To ... [more ▼]

In central Africa, most of the timber species require high light at the seedling stage for survival and growth. Forest managers face a regeneration shortage of these light-demanding timber species. To achieve long-term sustainability, there is a need for enrichment methods combining low cost and high species performance. The aim of this study was to assess the performance of Pericopsis elata seedlings in enriched logging gaps in Cameroon. Over five years; the survival and size of each seedling was monitored in 27 logging gaps that were either left without maintenance or cleared. Gaps were relatively small with an average total area of 155 m2. We found that planted seedlings of P. elata performed well in logging gaps. Even without any maintenance 61% of the planted seedlings survived after five years with an average annual diameter increment of 0.28 cm. P. elata appeared to be a good candidate species for enrichment in logging gaps. We demonstrated that the seedlings of P. elata tolerated a wide range of soil conditions but that their performance was strongly influenced by light availability (gap clearance), suggesting potentially improved performance of P. elata in high light environments such as in plantation or larger gaps. [less ▲]

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See detailNanocomposites based on MWCNT and polystyrene, styrene-acrylonitrile copolymer, or polymethylmethacrylate, obtained by miniemulsion polymerization
Donescu, Dan; Corobea, Mihai Cosmin; Petcu, Cristian et al

in Journal of Applied Polymer Science (2014), 131(23), 411481-10

Free radical miniemulsion polymerization of styrene (St), St/acrylonitrile 3 : 1 mixture or methylmethacrylate in the presence of multiwalled carbon nanotubes (MWCNT) was proven as a convenient way to ... [more ▼]

Free radical miniemulsion polymerization of styrene (St), St/acrylonitrile 3 : 1 mixture or methylmethacrylate in the presence of multiwalled carbon nanotubes (MWCNT) was proven as a convenient way to obtain homogenous hybrids with perspectives in associated applications like foams specialties materials. Miniemulsion polymerization was viable up to 2% wt. MWCNT to monomer, without agglomerations. The grafting on MWCNT during the polymerization occurs without the need for supplementary functionalization and the polymer grafted nanotubes showed stable dispersions in the polymer solvent. Monomer polarity affected the grafting ability during the polymerization process. The nanocomposites obtained after purification and drying were used in foaming process. MWCNT presence in the related nanocomposites decreased the pore sizes in foam-like materials (for all three different matrices). At 1 wt % MWCNT content, low density (< 0.3 g/cm3), low pore size (< 10 μm) and high cell density (>109 cell/cm3) were achieved. [less ▲]

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See detailFirst-line crizotinib versus chemotherapy in ALK-positive lung cancer.
Solomon, Benjamin J.; Mok, Tony; Kim, Dong-Wan et al

in The New England journal of medicine (2014), 371(23), 2167-77

BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We ... [more ▼]

BACKGROUND: The efficacy of the ALK inhibitor crizotinib as compared with standard chemotherapy as first-line treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC) is unknown. METHODS: We conducted an open-label, phase 3 trial comparing crizotinib with chemotherapy in 343 patients with advanced ALK-positive nonsquamous NSCLC who had received no previous systemic treatment for advanced disease. Patients were randomly assigned to receive oral crizotinib at a dose of 250 mg twice daily or to receive intravenous chemotherapy (pemetrexed, 500 mg per square meter of body-surface area, plus either cisplatin, 75 mg per square meter, or carboplatin, target area under the curve of 5 to 6 mg per milliliter per minute) every 3 weeks for up to six cycles. Crossover to crizotinib treatment after disease progression was permitted for patients receiving chemotherapy. The primary end point was progression-free survival as assessed by independent radiologic review. RESULTS: Progression-free survival was significantly longer with crizotinib than with chemotherapy (median, 10.9 months vs. 7.0 months; hazard ratio for progression or death with crizotinib, 0.45; 95% confidence interval [CI], 0.35 to 0.60; P<0.001). Objective response rates were 74% and 45%, respectively (P<0.001). Median overall survival was not reached in either group (hazard ratio for death with crizotinib, 0.82; 95% CI, 0.54 to 1.26; P=0.36); the probability of 1-year survival was 84% with crizotinib and 79% with chemotherapy. The most common adverse events with crizotinib were vision disorders, diarrhea, nausea, and edema, and the most common events with chemotherapy were nausea, fatigue, vomiting, and decreased appetite. As compared with chemotherapy, crizotinib was associated with greater reduction in lung cancer symptoms and greater improvement in quality of life. CONCLUSIONS: Crizotinib was superior to standard first-line pemetrexed-plus-platinum chemotherapy in patients with previously untreated advanced ALK-positive NSCLC. (Funded by Pfizer; PROFILE 1014 ClinicalTrials.gov number, NCT01154140.). [less ▲]

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See detailMixed modes in red giants: a window on stellar evolution
Mosser, B.; Benomar, O.; Belkacem, K. et al

in Astronomy and Astrophysics (2014), 572

Context. The detection of oscillations with a mixed character in subgiants and red giants allows us to probe the physical conditions in their cores. <BR /> Aims: With these mixed modes, we aim at ... [more ▼]

Context. The detection of oscillations with a mixed character in subgiants and red giants allows us to probe the physical conditions in their cores. <BR /> Aims: With these mixed modes, we aim at determining seismic markers of stellar evolution. <BR /> Methods: Kepler asteroseismic data were selected to map various evolutionary stages and stellar masses. Seismic evolutionary tracks were then drawn with the combination of the frequency and period spacings. <BR /> Results: We measured the asymptotic period spacing for 1178 stars at various evolutionary stages. This allows us to monitor stellar evolution from the main sequence to the asymptotic giant branch and draw seismic evolutionary tracks. We present clear quantified asteroseismic definitions that characterize the change in the evolutionary stages, in particular the transition from the subgiant stage to the early red giant branch, and the end of the horizontal branch. <BR /> Conclusions: The seismic information is so precise that clear conclusions can be drawn independently of evolution models. The quantitative seismic information can now be used for stellar modeling, especially for studying the energy transport in the helium-burning core or for specifying the inner properties of stars entering the red or asymptotic giant branches. Modeling will also allow us to study stars that are identified to be in the helium-subflash stage, high-mass stars either arriving or quitting the secondary clump, or stars that could be in the blue-loop stage. Table 1 is only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/L5">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/L5</A> [less ▲]

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See detailAlignment of quasar polarizations with large-scale structures
Hutsemekers, Damien ULg; Braibant, Lorraine ULg; Pelgrims, Vincent ULg et al

in Astronomy and Astrophysics (2014), 572

We have measured the optical linear polarization of quasars belonging to Gpc scale quasar groups at redshift z ~ 1.3. Out of 93 quasars observed, 19 are significantly polarized. We found that quasar ... [more ▼]

We have measured the optical linear polarization of quasars belonging to Gpc scale quasar groups at redshift z ~ 1.3. Out of 93 quasars observed, 19 are significantly polarized. We found that quasar polarization vectors are either parallel or perpendicular to the directions of the large-scale structures to which they belong. Statistical tests indicate that the probability that this effect can be attributed to randomly oriented polarization vectors is on the order of 1%. We also found that quasars with polarization perpendicular to the host structure preferentially have large emission line widths while objects with polarization parallel to the host structure preferentially have small emission line widths. Considering that quasar polarization is usually either parallel or perpendicular to the accretion disk axis depending on the inclination with respect to the line of sight, and that broader emission lines originate from quasars seen at higher inclinations, we conclude that quasar spin axes are likely parallel to their host large-scale structures. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under program ID 092.A-0221.Table 1 is available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424631/olm">http://www.aanda.org</A> [less ▲]

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See detailWASP-94 A and B planets: hot-Jupiter cousins in a twin-star system
Neveu-VanMalle, M.; Queloz, D.; Anderson, D. R. et al

in Astronomy and Astrophysics (2014), 572

We report the discovery of two hot-Jupiter planets, each orbiting one of the stars of a wide binary system. <ASTROBJ>WASP-94A</ASTROBJ> (<ASTROBJ>2MASS 20550794-3408079</ASTROBJ>) is an F8 type star ... [more ▼]

We report the discovery of two hot-Jupiter planets, each orbiting one of the stars of a wide binary system. <ASTROBJ>WASP-94A</ASTROBJ> (<ASTROBJ>2MASS 20550794-3408079</ASTROBJ>) is an F8 type star hosting a transiting planet with a radius of 1.72 ± 0.06 R<SUB>Jup</SUB>, a mass of 0.452 ± 0.034 M<SUB>Jup</SUB>, and an orbital period of 3.95 days. The Rossiter-McLaughlin effect is clearly detected, and the measured projected spin-orbit angle indicates that the planet occupies a retrograde orbit. <ASTROBJ>WASP-94B</ASTROBJ> (<ASTROBJ>2MASS 20550915-3408078</ASTROBJ>) is an F9 stellar companion at an angular separation of 15'' (projected separation 2700 au), hosting a gas giant with a minimum mass of 0.618 ± 0.028 M<SUB>Jup</SUB> with a period of 2.008 days, detected by Doppler measurements. The orbital planes of the two planets are inclined relative to each other, indicating that at least one of them is inclined relative to the plane of the stellar binary. These hot Jupiters in a binary system bring new insights into the formation of close-in giant planets and the role of stellar multiplicity. The radial-velocity and photometric data used for this work are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/A49">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/572/A49</A> [less ▲]

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See detailThe use of microorganisms of cassava retting for the production of pectinolytic enzymes
Kouhounde, Sonagnon Hermann Serge ULg; Adeoti, Kifouli; Delvigne, Frank ULg et al

in Journal of Microbiology Biotechnology and Food Sciences (2014), 4(3), 277-281

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See detailShort-term spectroscopic variability of Plaskett's star
Palate, Matthieu ULg; Rauw, Grégor ULg

in Astronomy and Astrophysics (2014), 572

Context. Plaskett's star (HD 47129) is a very massive O-star binary in a post Roche-lobe overflow stage. CoRoT observations of this system revealed photometric variability with a number of frequencies ... [more ▼]

Context. Plaskett's star (HD 47129) is a very massive O-star binary in a post Roche-lobe overflow stage. CoRoT observations of this system revealed photometric variability with a number of frequencies. <BR /> Aims: The aim of this paper is to characterize the variations in spectroscopy and investigate their origin. <BR /> Methods: To sample its short-term variability, HD 47129 was intensively monitored during two spectroscopic campaigns of six nights each. The spectra were disentangled and Fourier analyses were performed to determine possible periodicities and to investigate the wavelength dependence of the phase constant and the amplitude of the periodicities. <BR /> Results: Complex line profile variations are observed. Frequencies near 1.65, 0.82, and 0.37 d[SUP]-1[/SUP] are detected consistently in the He i λ 4471, He ii λ 4542, and N iii λ 4510-4518 lines. These frequencies are consistent with those of the strongest signals detected in photometry. The possibilities that these variations stem from pulsations, a recently detected magnetic field or tidal interactions are discussed. <BR /> Conclusions: Whilst all three scenarios have their strengths, none of them can currently account for all the observed properties of the line profile variations. Based on observations collected at the Observatoire de Haute Provence (OHP, France). [less ▲]

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See detailVitrification, an efficient cryopreservation procedure but still rising some debates
Vanderzwalmen, Pierre; Ectors, Fabien ULg; Stecher, Astrid et al

in Current Trends in Clinical Embryology (2014), 1(1), 34-45

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See detailDivision ethnoraciale et pénalisation
Vanneste, Charlotte ULg

in Revue de l'Institut de Sociologie de l'Université Libre de Bruxelles (2014), volume 2013

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