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See detailHigh-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Goyette, Philippe; Boucher, Gabrielle; Mallon, Dermot et al

in Nature Genetics (2015), 47(2), 172-9

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major ... [more ▼]

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD. [less ▲]

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See detailAssociation of Cerebrospinal Fluid Prion Protein Levels and the Distinction Between Alzheimer Disease and Creutzfeldt-Jakob Disease
Dorey, Aline; Tholance, Yannick; Vighetto, Alain et al

in JAMA Neurology (2015)

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological ... [more ▼]

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia presentation. OBJECTIVE To assess the relevance of total CSF prion protein (t-PrP) levels in the differential biological diagnosis between atypical AD phenotypes and CJD. DESIGN, SETTING, AND PARTICIPANTS A retrospective study in an autopsy-confirmed cohort of 82 patients was performed to evaluate the relevance of CSF t-PrP to distinguish 30 definite cases of AD from 52 definite cases of CJD. Next, CSF t-PrP concentration was measured in a cohort of 104 patients including 55 patients with probable AD, 26 with probable sporadic CJD, and 23 control patients for whom 14-3-3 protein, total tau, phosphorylated tau 181 (P-tau181), and Aβ1-42 were available.We investigated 46 patients diagnosed as having probable AD who presented atypical phenotypes. A diagnosis strategy was proposed to classify atypical AD phenotypes with suspicion of CJD based on a decision tree combining CSF biomarkers. MAIN OUTCOMES AND MEASURES We determined CSF t-PrP levels for all patients.We calculated the ratio of total tau and P-tau181 and determined the diagnostic accuracy of each biomarker alone or in combination.We calculated the misclassification rate for each biomarker that corresponded to the percentage of patients within the group of atypical AD phenotypes wrongly classified as CJD. RESULTS In patients with CJD, CSF t-PrP concentrations were decreased compared with control participants and patients with AD. When considering the differential diagnosis of CJD compared with atypical AD phenotypes, CSF t-PrP determination reached 82.1%sensitivity and 91.3%specificity. The misclassification rate of atypical AD phenotypes decreased from 43.5%, obtained when using the CSF 14-3-3 protein determination alone, to only 4.3%when calculating the ratio total tau/(P-tau181 × t-PrP). The proposed classification tree permitted correct classification of 98.4%of the patients. CONCLUSIONS AND RELEVANCE For unusual phenotypes of AD, especially cases presenting with a biological ambiguity suggesting CJD, determination of CSF t-PrP levels increased diagnostic accuracy. The use of CSF t-PrP levels may be beneficial in clinical practice in [less ▲]

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See detailUpscaling of an electronic nose for continuously stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant
Adam, Gilles ULg; Lemaigre, Sébastien; Goux, Xavier et al

in Bioresource Technology (2015), 178

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to ... [more ▼]

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling's T² statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase. [less ▲]

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See detailSupraglacial lakes on the Greenland ice sheet advance inland under warming climate
Leeson, A.; Shepherd, A.; Briggs, K. et al

in Nature Climate Change (2015), 5

Supraglacial lakes (SGLs) form annually on the Greenland ice sheet and, when they drain, their discharge enhances ice-sheet flow by lubricating the base and potentially by warming the ice. Today, SGLs ... [more ▼]

Supraglacial lakes (SGLs) form annually on the Greenland ice sheet and, when they drain, their discharge enhances ice-sheet flow by lubricating the base and potentially by warming the ice. Today, SGLs tend to form within the ablation zone, where enhanced lubrication is offset by efficient subglacial drainage. However, it is not clear what impact a warming climate will have on this arrangement. Here, we use an SGL initiation and growth model to show that lakes form at higher altitudes as temperatures rise, consistent with satellite observations. Our simulations show that in southwest Greenland, SGLs spread 103 and 110 km further inland by the year 2060 under moderate (RCP 4.5) and extreme (RCP 8.5) climate change scenarios, respectively, leading to an estimated 48–53% increase in the area over which they are distributed across the ice sheet as a whole. Up to half of these new lakes may be large enough to drain, potentially delivering water and heat to the ice-sheet base in regions where subglacial drainage is inefficient. In such places, ice flow responds positively to increases in surface water delivered to the bed through enhanced basal lubrication and warming of the ice, and so the inland advance of SGLs should be considered in projections of ice-sheet change. [less ▲]

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See detailForbidden oxygen lines at various nucleocentric distances in comets
Decock, Alice ULg; Jehin, Emmanuel ULg; Rousselot, P. et al

in Astronomy and Astrophysics (2015), 573

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen ... [more ▼]

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen atoms using the ratio of the green-to-red-doublet emission intensity, I[SUB]5577[/SUB]/(I[SUB]6300[/SUB] + I[SUB]6364[/SUB]), (hereafter the G/R ratio) and the line velocity widths. <BR /> Methods: We acquired high-resolution spectroscopic observations at the ESO Very Large Telescope of comets C/2002 T7 (LINEAR), 73P-C/Schwassmann-Wachmann 3, 8P/Tuttle, and 103P/Hartley 2 when they were close to Earth (<0.6 au). Using the observed spectra, which have a high spatial resolution (<60 km/pixel), we determined the intensities and widths of the three [OI] lines. We spatially extracted the spectra to achieve the best possible resolution of about 1-2'', that is, nucleocentric projected distances of 100 to 400 km depending on the geocentric distance of the comet. We decontaminated the [OI] green line from C[SUB]2[/SUB] lines blends that we identified. <BR /> Results: The observed G/R ratio in all four comets varies as a function of nucleocentric projected distance (between ~0.25 to ~0.05 within 1000 km). This is mainly due to the collisional quenching of O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) by water molecules in the inner coma. The observed green emission line width is about 2.5 km s[SUP]-1[/SUP] and decreases as the distance from the nucleus increases, which can be explained by the varying contribution of CO[SUB]2[/SUB] to the O([SUP]1[/SUP]S) production in the innermost coma. The photodissociation of CO[SUB]2[/SUB] molecules seem to produce O([SUP]1[/SUP]S) closer to the nucleus, while the water molecule forms all the O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) atoms beyond 10[SUP]3[/SUP] km. Thus we conclude that the main parent species producing O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) in the inner coma is not always the same. The observations have been interpreted in the framework of the previously described coupled-chemistry-emission model, and the upper limits of the relative abundances of CO[SUB]2[/SUB] were derived from the observed G/R ratios. Measuring the [OI] lines might provide a new way to determine the CO[SUB]2[/SUB] relative abundance in comets. Based on observations made with ESO Telescope at the La Silla Paranal Observatory under programs ID 073.C-0525, 277.C-5016, 080.C-0615 and 086.C-0958.Tables 3 and 4 are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424403/olm">http://www.aanda.org</A> [less ▲]

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See detailMonte Carlo Simulation of Metastable Oxygen Photochemistry in Cometary Atmospheres
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULg et al

in The Astrophysical Journal (2015), 798

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical ... [more ▼]

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical processes lead to the production of other species generally absent from the nucleus, such as OH. Although all comets are different, they all have a highly rarefied atmosphere, which is an ideal environment for nonthermal photochemical processes to take place and influence the detailed state of the atmosphere. We develop a Monte Carlo model of the coma photochemistry. We compute the energy distribution functions (EDF) of the metastable O([SUP]1[/SUP]D) and O([SUP]1[/SUP]S) species and obtain the red (630 nm) and green (557.7 nm) spectral line shapes of the full coma, consistent with the computed EDFs and the expansion velocity. We show that both species have a severely non-Maxwellian EDF, that results in broad spectral lines and the suprathermal broadening dominates due to the expansion motion. We apply our model to the atmosphere of comet C/1996 B2 (Hyakutake) and 103P/Hartley 2. The computed width of the green line, expressed in terms of speed, is lower than that of the red line. This result is comparable to previous theoretical analyses, but in disagreement with observations. We explain that the spectral line shape does not only depend on the exothermicity of the photochemical production mechanisms, but also on thermalization, due to elastic collisions, reducing the width of the emission line coming from the O([SUP]1[/SUP]D) level, which has a longer lifetime. [less ▲]

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See detailV444 Cygni X-ray and polarimetric variability: Radiative and Coriolis forces shape the wind collision region
Lomax, J. R.; Nazé, Yaël ULg; Hoffman, J. L. et al

in Astronomy and Astrophysics (2015), 573

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind ... [more ▼]

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind structure within the system. We have created the most complete X-ray light curve of V444 Cyg to date using 40 ks of new data from Swift, and 200 ks of new and archived XMM-Newton observations. In addition, we have characterized the intrinsic, polarimetric phase-dependent behavior of the strongest optical emission lines using data obtained with the University of Wisconsin's Half-Wave Spectropolarimeter. We have detected evidence of the Coriolis distortion of the wind-wind collision in the X-ray regime, which manifests itself through asymmetric behavior around the eclipses in the system's X-ray light curves. The large opening angle of the X-ray emitting region, as well as its location (i.e. the WN wind does not collide with the O star, but rather its wind) are evidence of radiative braking/inhibition occurring within the system. Additionally, the polarimetric results show evidence of the cavity the wind-wind collision region carves out of the Wolf-Rayet star's wind. [less ▲]

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See detailThe binary near-Earth Asteroid (175706) 1996 FG3 - An observational constraint on its orbital evolution
Scheirich, P.; Pravec, P.; Jacobson, S. A. et al

in Icarus (2015), 245

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new ... [more ▼]

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new measurements constraining evolution of the mutual orbit with potential consequences for the entire binary asteroid population. We also refined previously determined values of parameters of both components, making 1996 FG<SUB>3</SUB> one of the most well understood binary asteroid systems. With our 17-year long dataset, we determined the orbital vector with a substantially greater accuracy than before and we also placed constraints on a stability of the orbit. Specifically, the ecliptic longitude and latitude of the orbital pole are 266 ° and - 83 ° , respectively, with the mean radius of the uncertainty area of 4 ° , and the orbital period is 16.1508 ± 0.0002 h (all quoted uncertainties correspond to 3σ). We looked for a quadratic drift of the mean anomaly of the satellite and obtained a value of 0.04 ± 0.20 deg /yr<SUP>2</SUP> , i.e., consistent with zero. The drift is substantially lower than predicted by the pure binary YORP (BYORP) theory of McMahon and Scheeres (McMahon, J., Scheeres, D. [2010]. Icarus 209, 494-509) and it is consistent with the tigidity and quality factor of μQ = 1.3 ×10<SUP>7</SUP> Pa using the theory that assumes an elastic response of the asteroid material to the tidal forces. This very low value indicates that the primary of 1996 FG<SUB>3</SUB> is a 'rubble pile', and it also calls for a re-thinking of the tidal energy dissipation in close asteroid binary systems. [less ▲]

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See detailDust from Comet 209P/LINEAR during its 2014 Return: Parent Body of a New Meteor Shower, the May Camelopardalids
Ishiguro, Masateru; Kuroda, Daisuke; Hanayama, Hidekazu et al

in The Astrophysical Journal Letters (2015), 798

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was ... [more ▼]

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was apparently inactive at a heliocentric distance r<SUB>h</SUB> = 1.6 AU and showed weak activity at r<SUB>h</SUB> <= 1.4 AU. We found an active region of <0.001% of the entire nuclear surface during the comet's dormant phase. An edge-on image suggests that particles up to 1 cm in size (with an uncertainty of factor 3-5) were ejected following a differential power-law size distribution with index q = –3.25 ± 0.10. We derived a mass-loss rate of 2-10 kg s<SUP>–1</SUP> during the active phase and a total mass of ≈5 × 10<SUP>7</SUP> kg during the 2014 return. The ejection terminal velocity of millimeter- to centimeter-sized particles was 1-4 m s<SUP>–1</SUP>, which is comparable to the escape velocity from the nucleus (1.4 m s<SUP>–1</SUP>). These results imply that such large meteoric particles marginally escaped from the highly dormant comet nucleus via the gas drag force only within a few months of the perihelion passage. [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailFeature issue of digital holography and 3D imaging (DH): introduction
Hayasaki, Yoshio; Liu, Jung-Ping; Georges, Marc ULg

in Applied Optics (2015), 54(1), 1-2

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO ... [more ▼]

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO) since 2007. In this year (2014), Optics Express (OE) and AO jointly decided to have one such feature issue in each journal. The feature issue includes 27 papers and covers a large range of topics, reflecting the rapidly expanding techniques and applications of digital holography and 3D imaging. The DH meeting will continue in the future, as expected, and the next meeting is scheduled to be held on24–28 May 2015, at Shanghai Institute of Optics and Fine Mechanics, Shanghai, China. [less ▲]

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See detailThe Gaia-ESO Survey: CNO abundances in the open clusters Trumpler 20, NGC 4815, and NGC 6705
Tautvaišienė, G.; Drazdauskas, A.; Mikolaitis, Š. et al

in Astronomy and Astrophysics (2015), 573

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim ... [more ▼]

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim to determine C, N, and O abundances in stars of Galactic open clusters of the Gaia-ESO survey and to compare the observed abundances with those predicted by current stellar and Galactic evolution models. In this pilot paper, we investigate the first three intermediate-age open clusters. <BR /> Methods: High-resolution spectra, observed with the FLAMES-UVES spectrograph on the ESO VLT, were analysed using a differential model atmosphere method. Abundances of carbon were derived using the C[SUB]2[/SUB] band heads at 5135 and 5635.5 Å. The wavelength interval 6470-6490 Å, with CN features, was analysed to determine nitrogen abundances. Oxygen abundances were determined from the [O i] line at 6300 Å. <BR /> Results: The mean values of the elemental abundances in Trumpler 20 as determined from 42 stars are: [ Fe/H ] = 0.10 ± 0.08 (s.d.), [ C/H ] = -0.10 ± 0.07, [ N/H ] = 0.50 ± 0.07, and consequently C/N = 0.98 ± 0.12. We measure from five giants in NGC 4815: [ Fe/H ] = -0.01 ± 0.04, [ C/H ] = -0.17 ± 0.08, [ N/H ] = 0.53 ± 0.07, [ O/H ] = 0.12 ± 0.09, and C/N = 0.79 ± 0.08. We obtain from 27 giants in NGC 6705: [ Fe/H ] = 0.0 ± 0.05, [ C/H ] = -0.08 ± 0.06, [ N/H ] = 0.61 ± 0.07, [ O/H ] = 0.13 ± 0.05, and C/N = 0.83 ± 0.19. The C/N ratios of stars in the investigated open clusters were compared with the ratios predicted by stellar evolutionary models. For the corresponding stellar turn-off masses from 1.9 to 3.3 M[SUB]⊙[/SUB], the observed C/N ratio values are very close to the predictions of standard first dredge-up models as well as to models of thermohaline extra-mixing. They are not decreased as much as predicted by the recent model in which the thermohaline- and rotation-induced extra-mixing act together. The average [O/H] abundance ratios of NGC 4815 and NGC 6705 are compared with the predictions of two Galactic chemical evolution models. The data are consistent with the evolution at the solar radius within the errors. <BR /> Conclusions: The first results of CNO determinations in open clusters show the potential of the Gaia-ESO Survey to judge stellar and Galactic chemical evolution models and the validity of their physical assumptions through a homogeneous and detailed spectral analysis. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002 (The Gaia-ESO Public Spectroscopic Survey, PIs G. Gilmore and S. Randich). [less ▲]

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See detailCan the collapse of a fly ash heap develop into an air-fluidized flow? - Reanalysis of the Jupille accident (1961)
Stilmant, Frédéric ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Geomorphology (2015), 228

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of ... [more ▼]

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of fluidization attracted scientific attention. As drillings and direct observations revealed no water-saturated zone at the base of the deposits, scientists assumed an air-fluidization mechanism, which appeared consistent with the properties of the material. In this paper, the air-fluidization assumption is tested based on two-dimensional numerical simulations. The numerical model has been developed so as to focus on the most prominent processes governing the flow, with parameters constrained by their physical interpretation. Results are compared to accurate field observations and are presented for different stages in the model enhancement, so as to provide a base for a discussion of the relative influence of pore pressure dissipation and pore pressure generation. These results show that the apparently high diffusion coefficient that characterizes the dissipation of air pore pressures is in fact sufficiently low for an important degree of fluidization to be maintained during a flow of hundreds of meters. [less ▲]

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See detailEvidence that Pluto's atmosphere does not collapse from occultations including the 2013 May 04 event
Olkin, C. B.; Young, L. A.; Borncamp, D. et al

in Icarus (2015), 246

Combining stellar occultation observations probing Pluto's atmosphere from 1988 to 2013, and models of energy balance between Pluto's surface and atmosphere, we find the preferred models are consistent ... [more ▼]

Combining stellar occultation observations probing Pluto's atmosphere from 1988 to 2013, and models of energy balance between Pluto's surface and atmosphere, we find the preferred models are consistent with Pluto retaining a collisional atmosphere throughout its 248-year orbit. The occultation results show an increasing atmospheric pressure with time in the current epoch, a trend present only in models with a high thermal inertia and a permanent N<SUB>2</SUB> ice cap at Pluto's north rotational pole. [less ▲]

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See detailSeasonal variability of meiofauna, especially harpacticoid copepods, in Posidonia oceanica macrophytodetritus accumulations
Mascart, Thibaud ULg; Lepoint, Gilles ULg; Deschoemaeker, Silke et al

in Journal of Sea Research (2015), 95

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated ... [more ▼]

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated sand patches and (2) to elucidate the community structure of detritus-associated harpacticoid copepods in relation to natural temporal variability of physico-chemical characteristics of accumulations. This was investigated in a Posidonia oceanica (L.) Delile seagrass ecosystem in the northwest Mediterranean Sea (Bay of Calvi, Corsica, 42°35’N, 8°43’E) using a triplicate macrophytodetritus core field sampling in two contrasting sites over the four seasons of 2011. Meiofauna higher taxa consisted of 50% Copepoda, which 87% belonged to the Harpacticoida order. Nematoda was the second most abundant taxa. The copepod community displayed a wide variety of morphologically similar and ecologically different species (i.e. mesopsammic, phytal, phytal-swimmers, planktonic and parasitic). The harpacticoid copepod community followed a strong seasonal pattern with highest abundances and species diversity in May-August, revealing a link with the leaf litter epiphyte primary production cycle. Aside from the important role in sheltering, housing and feeding potential of macrophytodetritus, a harpacticoid community BEST analysis demonstrated a positive correlation with habitat complexity and a negative correlation with water movements and P. oceanica leaf litter accumulation. [less ▲]

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See detailN1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase
Henrottin, Jean ULg; Zervosen, Astrid ULg; Lemaire, Christian ULg et al

in ACS Medicinal Chemistry Letters (2015)

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive ... [more ▼]

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive properties in inflammatory and tumoral tissues. The syntheses of 1-(2-fluoroethyl)-tryptophan (1-FETrp) and 1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-tryptophan, two N1-fluoroalkylated tryptophan derivatives, are described here. In vitro enzymatic assays with these two new potential substrates of hIDO show that 1-FETrp is a good and specific substrate of hIDO. Therefore, its radioactive isotopomer, 1-[18F]FETrp, should be a molecule of choice to visualize tumoral and inflammatory tissues and/or to validate new potential inhibitors. [less ▲]

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (2015), 55(1), 73-91

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailStimuli-responsive behavior of micelles prepared from a poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer
Poggi, Elio; Guerlain, Claire; Debuigne, Antoine ULg et al

in European Polymer Journal (2015), 62

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4 ... [more ▼]

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4-vinylpyridine) precursor (PVAc-b-PAN-b-P4VP) synthesized by a combination of cobalt-mediated radical polymerization (CMRP) and nitroxide mediated polymerization (NMP). The PVOH-b-PAA-b-P4VP terpolymer is further micellized in water and the accordingly obtained micellar structures are characterized by a combination of dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM) as a function of pH. Well-defined micelles are observed in the whole pH range except for pH values below 4.5 where non-aggregated chains (unimers) are present. The formation of micelles can be rationalized by the formation of insoluble PAA/P4VP inter-polyelectrolyte complexes in the 4.5–6 pH range while hydrophobic P4VP cores are observed at pH values above 6. Finally, the effect of the addition of different salts on the micellar characteristic features is investigated. [less ▲]

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See detailVascular calcification: from pathophysiology to biomarkers
EVRARD, Séverine ULg; DELANAYE, Pierre ULg; Kamel, S et al

in Clinica Chimica Acta (2015), 438

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have ... [more ▼]

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlightedmore and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood,many questions still remain unanswered. This reviewbriefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed. [less ▲]

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See detailSEM and EDS observations of carrollite bioleaching with a mixed culture of acidophilic bacteria
Nkulu, Guy; Gaydardzhiev, Stoyan ULg; Mwema, Edouard et al

in Minerals Engineering (2015), doi:10.1016/j.mineng.2014.12.005

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to ... [more ▼]

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to provide evidence of the interaction pattern between carrollite and microorganisms. A bacterial consortium involving three different acidophilic chemolithotrophs was adopted. The evolution of the surface topography, inside alteration effects and elemental composition of the mineral with leaching time was followed. It could be postulated that bacterial adhesion takes place on the mineral surface, resulting in the formation of dissolution pits of various shapes and continues by boring elongated channels deep inside the mineral grains. Enhanced concentration of ferric iron and sulphur could be assumed in vicinity of the zones where mineralized polymer substances are precipitated. It could be inferred that carrollite dissolution is governed by cooperative bioleaching involving oxidation induced by bacteria attached to the surface and ferric iron re-oxidized by planktonic bacteria in suspension. [less ▲]

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See detailExiste-t-il des phénomènes mentaux?
Dewalque, Arnaud ULg; Seron, Denis ULg

in Philosophie (2015), 124

This paper offers a critical discussion of the so-called argument from the transparency of experience. We recall of the argument against the historical background of phenomenal anti-dualism (Natorp, Wundt ... [more ▼]

This paper offers a critical discussion of the so-called argument from the transparency of experience. We recall of the argument against the historical background of phenomenal anti-dualism (Natorp, Wundt, Russell) and identify three difficulties of it. Eventually, we propose an alternative view, which we call phenomenological dualism. On the proposed view, there is a sense in which our mental states may be said to appear to us, hence there is a sense to say that there are mental phenomena. [less ▲]

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See detailThree-Parameter Kinematic Theory for Shear Behavior of Continuous Deep Beams
Mihaylov, Boyan ULg; Hunt, Bradley; Bentz, Evan et al

in ACI Structural Journal (2015), 112(1), 47-57

This paper presents a theory for predicting shear strengths, deformations, and crack widths near failure of continuous deep beams. To describe the deformations in continuous deep beams, the theory uses a ... [more ▼]

This paper presents a theory for predicting shear strengths, deformations, and crack widths near failure of continuous deep beams. To describe the deformations in continuous deep beams, the theory uses a three-degree-of-freedom kinematic model (3PKT), which is an extension of an earlier two-degree-of-freedom model (2PKT) for members in single curvature. The extended model is validated with the help of measured local and global deformations taken during loading to failure of a large continuous deep beam. The accuracy of the shear-strength predictions given by the theory is evaluated using a database of 129 published tests of continuous deep beams. The theory enables the load distribution and failure loads of continuous deep beams subject to differential settlement to be evaluated. [less ▲]

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See detailRhoGTPases as Key players in mammalian cell adaptation to microgravity.
Louis, Fiona; Deroanne, Christophe ULg; Nusgens-Richelle, Betty ULg et al

in BioMed Research International (2015)

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See detailImpact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability
Frère, Antoine ULg; Kawalec, Michal; Tempelaar, Sarah et al

in Biomacromolecules (2015)

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or ... [more ▼]

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or morpholino functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups), of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5 was evaluated. The use of one of these polymers combining morpholine and guanidine functions at the ratio >1 and hydrophobic trimethylene carbonate groups showed a significant decrease of mRNA and protein level in HeLa cells, similar to PEI. These results highlight the potential of polycarbonate vectors for future in vivo application as an anti-cancer therapy. [less ▲]

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See detailEinleitung
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), -

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See detailSoft power, global governance of cultural industries and rising powers: the case of China
Vlassis, Antonios ULg

in International Journal of Cultural Policy (2015)

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to ... [more ▼]

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to shape the structures of their international environment. More specifically, studying the cases of People’s Republic of China and of the movie industry, my article focuses on the current evolution of the relationship between the Chinese authorities and the film industry, as well as on the development of the domestic film market. I further aim to draw up an inventory of China’s role within the global governance of cultural industries. Finally, I aim to highlight the global cultural competition that China faces, emphasizing the practices of the US administration and Hollywood. I argue that even if China is the current centre of gravity within the world economy, it still has a long way to go in order to shape the distribution of resources within the global governance of cultural industries and to play a crucial role in the international battle of cultural symbols. [less ▲]

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See detail18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneite and Functional Tumor Volume in a Multi-Cancer Site Patient Cohort
HATT, MAT; MAJDOUB, MOHAMED; VALLIERES, MARTIN et al

in Journal of Nuclear Medicine (The) (2015), 56(1), 38-44

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See detailPrise en charge d'un cancer du sein chez une femme porteuse de prothèses mammaires
REMACLE, Sarah; LIFRANGE, Eric ULg; NIZET, Jean-Luc ULg

in Revue Médicale de Liège (2015), 70

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning ... [more ▼]

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning the risk of inducing breast cancer or delaying the diagnosis, however, no significant causal relationship has been established. The purpose of this article is to assess the diagnostic and therapeutic consequences when breast cancer is identified in a patient with breast implants. [less ▲]

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See detailA simulation study comparing multiple imputation methods for incomplete longitudinal ordinal data
Donneau, Anne-Françoise ULg; Mauer, Murielle; Molenberghs, Geert et al

in Communications in Statistics : Simulation & Computation (2015), 44(5), 1311-1338

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See detail“Rhizoponics”: a novel hydroponic rhizotron for root system analyses on mature Arabidopsis thaliana plants
Mathieu, Laura ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

in Plant Methods (2015), 11

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to ... [more ▼]

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to adult stages, i.e. from seed to seed. This system offers the advantages of hydroponics such as control of root environment and easy access to the roots for measurements or sampling. Being completely movable and low cost, it can be used in controlled cabinets. We chose the case of cadmium treatment to illustrate potential applications, from cell to organ levels. [less ▲]

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See detailDegree of phosphorus saturation in agricultural loamy soils with a near-neutral pH
Renneson, Malorie ULg; Vandenberghe, Christophe ULg; Dufey, Joseph et al

in European Journal of Soil Science (2015), 66

The degree of phosphorus saturation (DPS) represents the ratio of sorbed phosphorus (P) to the P sorption capacity (PSC) of soils. In some countries, DPS is used to evaluate the risk of P loss and surface ... [more ▼]

The degree of phosphorus saturation (DPS) represents the ratio of sorbed phosphorus (P) to the P sorption capacity (PSC) of soils. In some countries, DPS is used to evaluate the risk of P loss and surface water eutrophication. This study investigated DPS measurement and prediction in neutral loamy soils fromWallonia, Belgium. A total of 57 agricultural topsoil samples subject to diverse P management were evaluated. No satisfactory relationship could be found between PSC determined by a one-point short-term isotherm in the laboratory and the sum of aluminium and iron extracted by oxalate (Alox +Feox). The equation PSC=a Alox +b pHw appeared to be more appropriate for estimating PSC in the soils studied. These soils had a near-neutral pH, and P fixation processes linked to the presence of calcium ions or carbonates were important. Comparisons of DPS with soil-test P and water-extracted P suggested that DPS could be a useful agronomic and/or environmental indicator. Our results also showed that DPS values between 20 and 30% corresponded to the agronomic optimum of soil P content. Consequently, DPS may be used as an indicator of P status in neutral soils, provided that the PSC assessment is adapted to the local soil characteristics. [less ▲]

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See detailLa France et le Congo ex-belge (1961-1965). Intérêts et influences en mutation
Genin, Vincent ULg

in Revue Belge de Philologie et d'Histoire (2015), 91(2013/4), 1057-1110

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective ... [more ▼]

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective. Ostracized by the United Nations in the summer of 1960 in the context of the Congolese crisis, Belgium has, however, been able to count on the support of France, itself immobilized by the Algerian case. Based on unpublished archives, it seems instructive to study the evolution of the Franco-Belgian relations, in terms of Central African Affairs from 1961 to 1965. France, the overseas influence policy is a fundamental factor, she will devote as much energy to develop and defend its interests in Congo former Belgian (on which she claimed in Brussels its preemptive right, dating back to 1884, spring 1960) as former territories of the French Community? What are the forms, the protagonists and channels (formal and informal) of this influence; how is she fits the postcolonial context and she has an impact on Franco-Belgian relations ? [less ▲]

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See detailIn situ bidentate to tetradentate ligand exchange reaction in cobalt-mediated radical polymerization
Kermagoret, Anthony ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

in European Polymer Journal (2015), 62

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this, none of the reported complexes offers optimal control for monomers with very different reactivity, which somewhat limits the synthesis of copolymers. In order to expand the scope of cobalt-mediated radical polymerization (CMRP), we investigated an in situ ligand exchange reaction for modulating the properties of the cobalt complex at the polymer chain-end and adjusting the C-Co bond strength involved in the control process. With the aim of improving the synthesis of poly(vinyl acetate)-b-poly(n-butyl acrylate) copolymers, bidentate acetylacetonate ligands, which impart high level of control to the polymerization of vinyl acetate (VAc), were replaced in situ at the PVAc-cobalt chain-end by tetradentate Salen type ligands that are more suited to acrylates. [less ▲]

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See detailEpidemiological Review of Injuries in Rugby Union
Kaux, Jean-François ULg; Julia, Marc; Delvaux, François ULg et al

in Sports (2015), 3(1), 21-29

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This ... [more ▼]

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This epidemiological review of injuries incurred by rugby players mentions the position and type of injuries, the causes, time during the match and season in which they occur and the players’ positions as well as the length of players’ absences following the injury. [less ▲]

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See detailEarly colonization on Artificial Seagrass Units and on Posidonia oceanica (L.) Delile leaves
Pete, Dorothée ULg; Lepoint, Gilles ULg; Bouquegneau, Jean-Marie ULg et al

in Belgian Journal of Zoology (2015), 145(1), 59-68

Many epiphytes grow on Posidonia oceanica (L.) Delile leaves but early stages of that colonization are not well known. To study this early colonization without destroying the plant, Artificial Seagrass ... [more ▼]

Many epiphytes grow on Posidonia oceanica (L.) Delile leaves but early stages of that colonization are not well known. To study this early colonization without destroying the plant, Artificial Seagrass Units (ASUs) were utilised. The first nine days of colonization by macroscopic eukaryotic organisms on natural P. oceanica leaves and on ASUs were studied. The capability of those ASUs to mimic P. oceanica in the long term was also evaluated. Indeed, early colonists of a substrate can influence the settling of later ones by “priority effects”. Thus if the pioneer community is the same on both substrates, they will more likely be the same after a longer exposure time. On both substrates, colonization began by the settling of crustose-calcareous algae and foraminiferans. The number of organisms increased more quickly on ASUs than on natural leaves but Shannon-Wiener diversity index was higher for P. oceanica leaves. The low colonization rate on natural leaves may have been due to different microclimatic conditions on the two substrates and to a less developed biofilm than on ASUs. The high diversity observed on natural leaves was mainly related to the presence of bryozoan ancestrulae, which were absent on ASUs. Different microhabitats on each substrate (different algae morphotypes) can explain this difference. Thus, at such an early colonization stage, pioneer communities were different on the two substrates, suggesting that later communities would be different too. However, ASUs could be used in environmental perturbation studies instead of natural leaves, thanks to their high colonization rate. [less ▲]

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See detailCompte-rendu de l'ouvrage d'Eva Illouz : "Hard Romance : "Cinquante nuances de Grey" et nous" (2014)
Ledent, David ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2015)

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See detailThe Reputation Effect: A Case Study of Credit Contracts in Transition Countries
Artige, Lionel ULg; Nicolini, Rosella

in International Journal of Finance and Banking Studies (2015), 4(1), 1-17

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See detailL'évaluation émancipatrice, l'évaluateur et les formes de la communauté
Absil, Gaëtan ULg; Vandoorne, Chantal ULg

in L'Observatoire (2015), 82(Janvier-Février-Mars 2015), 30-35

Cet article explore des enjeux de l’évaluation émancipatrice d’un projet de santé communautaire, d’un programme transfrontalier de promotion de la santé mentale et de projets de promotion de la santé par ... [more ▼]

Cet article explore des enjeux de l’évaluation émancipatrice d’un projet de santé communautaire, d’un programme transfrontalier de promotion de la santé mentale et de projets de promotion de la santé par les services de santé scolaire. Ces enjeux sont questionnés selon les axes politique, opérationnel ou constructiviste de l’évaluation. Le propos porte sur les liens entre l’évaluation émancipatrice et la communauté formée par les stakeholders. Il ouvre une réflexion sur les enjeux micro, méso et macro sociaux de l’évaluation et la posture de l’évaluateur. [less ▲]

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See detailThe Ras/Rap GTPase activating protein RASA3 : from gene structure to in vivo functions
Schurmans, Stéphane ULg; Polizzi, Séléna; Scoumanne, Ariane ULg et al

in Advances in Biological Regulation (2015), 57

RASA3 (or GTPase Activating Protein III, R-Ras GTPase-activating protein, GAP1IP4BP) is a GTPase activating protein of the GAP1 subfamily which targets Ras and Rap1. RASA3 was originally purified from pig ... [more ▼]

RASA3 (or GTPase Activating Protein III, R-Ras GTPase-activating protein, GAP1IP4BP) is a GTPase activating protein of the GAP1 subfamily which targets Ras and Rap1. RASA3 was originally purified from pig platelet membranes through its intrinsic ability to bind inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) with high affinity, hence its first name GAP1IP4BP (for GAP1 subfamily member which binds I(1,3,4,5)P4). RASA3 was thus the first I(1,3,4,5)P4 receptor identified and cloned. The in vitro and in vivo functions of RASA3 remained somewhat elusive for a long time. However, recently, using genetically-modified mice and cells derived from these mice, the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. The goal of this review is thus to summarize and comment recent and less recent data in the literature on RASA3, in particular on the in vivo function of this specific GAP1 subfamily member. [less ▲]

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
FRIPPIAT, Frédéric ULg; Musuamba, FT; Seidel, Laurence ULg et al

in Journal of Antimicrobial Chemotherapy (2015)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean ± SEM: 0.29 ± 0.030 versus 0.20 ± 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

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See detailPossibilities for Co(III) dissolution from an oxidized ore through simultaneous bioleaching of pyrite
Zeka, Leon; Lambert, Fanny ULg; Frenay, Jean ULg et al

in Minerals Engineering (2015)

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and ... [more ▼]

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and abiotic experiments at various pulp densities and redox potentials have been performed and results compared. Cobalt leaching at elevated redox potential is possible, offering cost reduction benefits due to reduced consumption of ferrous iron. At elevated potential of 625 mV, however, the initial rate of cobalt leaching has been found as 115 mg/(g ore)⋅(24 h), lower than the rate of 865 mg/(g ore)⋅(24 h) registered at 505 mV. Less stochiometric amount of ferrous iron was required when cobalt leaching was coupled to pyrite bioleaching, with 75% of cobalt recovered for 12 h at the optimally found conditions. It could be inferred that the Fe3+–Fe2+ cycle exists and is efficiently maintained through bacterial presence in the studied system. [less ▲]

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See detailDevelopment and validation of an accelerometer-based method for quantifying gait events
Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg; Stamatakis, Julien et al

in Medical Engineering & Physics (2015)

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO ... [more ▼]

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO), and toe-off (TO), from wireless accelerometers applied to the right and left foot. First, the signals recorded from heel and toe three-axis accelerometers are segmented providing heel and toe flat phases. Then, the four gait events are defined from these flat phases. The accelerometer-based event identification was validated in seven healthy volunteers and a total of 247 trials against reference data provided by a force plate, a kinematic 3D analysis system, and video camera. HS, TS, HO, and TO were detected with a temporal accuracy ± precision of 1.3 ms ± 7.2 ms, ‒4.2 ms ± 10.9 ms, ‒3.7 ms ± 14.5 ms, and ‒1.8 ms ± 11.8 ms, respectively, with the associated 95% confidence intervals ranging from ‒6.3 ms to 2.2 ms. It is concluded that the developed accelerometer-based method can accurately and precisely detect HS, TS, HO, and TO, and could thus be used for the ambulatory monitoring of gait features computed from these events when measured concurrently in both feet. [less ▲]

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See detailCamorra in Montesacro. Urban and social transformation in a southern Italian community
De Biase, Marco ULg

in ECPR Standing Group on Organised Crime (2015), 12(1), 8-10

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See detailEvolution de la chalarose du frêne en Wallonie
Gerarts, Fanny ULg; Chandelier, Anne; Claessens, Hugues ULg et al

in Forêt Wallonne (2015), 134

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See detailLes conditions de possibilité du dialogue philosophique. Synthèse d'une discussion menée au séminaire de Peyriac-Sur-Mer (juin 2014).
Herla, Anne ULg

in Diotime. Revue internationale de didactique de la philosophie. (2015), 63

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See detailManufacturing of Kivuguto milk and stability in storage under refrigeration
Karenzi, Eugène; Fauconnier, Marie-Laure ULg; Destain, Jacqueline ULg et al

in European Scientific Journal (2015), 11(3), 1-16

The kivugutomilk was processed in a 20 liters bioreactor with three bacteria previously selected in kivuguto traditional milk. The work aimed to study the association of three bacteria previously selected ... [more ▼]

The kivugutomilk was processed in a 20 liters bioreactor with three bacteria previously selected in kivuguto traditional milk. The work aimed to study the association of three bacteria previously selected in traditional kivuguto in order to reproduce it in a controlled fermentation, and thereafter to understand its stability during storage under refrigeration. Postacidification, viability, proteolysis, flavor compounds as well as rheological characteristics were monitored for 36 days. The ph decreases from 4.54 to 4.45 and the titratable acidity grew from 73°d to 79°d. The final biomass after storage was 0.60 108 cfu.g-1 which is far higher than the recommended 106 cells.g-1before consumption. The proteolysis was at a range of 3.0 to 7.0 mg.l-1of lysine equivalent, which is too low so that it can’t produce bitter peptides. The evolution of flavor compounds in storage showed that no change found with 3-methylbutan-1-ol, acetic acid and furan-2(5h)-one, whilst pentan-1-ol and furanmethan-2-ol increased slightly upon 24 days’ storage. The complex viscosity decreased from 4 - 5.3 pas before storage to 2.9 - 4.0 pas corresponding respectively to the ratio g''/g' of about 0.3-0.4 with a very low variation. These data allowed the production and the good preservation of kivuguto milk at 4°c on 36 days. [less ▲]

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See detailGuaranteed Conditional Performance of the S2 Control Chart with Estimated Parameters
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Woodall, William

in International Journal of Production Research (2015)

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to ... [more ▼]

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to have confidence that the in-control average run length (ARL) obtained will be near the desired value. To overcome this problem, we adjust the S2 chart controls limits such that the in-control ARL is guaranteed to be above a specified value with a certain specified probability. The required adjustment does not have too much of an effect on the out-of-control performance of the chart. [less ▲]

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See detailEffect of stress path on the miniaturization size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Habraken, Anne ULg et al

in International Journal of Plasticity (2015), 64

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. The objective of this work is to provide new experimental results in order to analyze the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensile tests, large tensile tests and shear tests have been performed on Ni sheets with various grain sizes. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanical softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. From an industrial point of view, it is hence possible to improve the forming of microparts using suitable stress paths. [less ▲]

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See detailA plastic-damage model for concrete in fire: Applications in structural fire engineering
Gernay, Thomas ULg; Franssen, Jean-Marc ULg

in Fire Safety Journal (2015), 71

The research aims at developing a new multiaxial constitutive model for concrete in the fire situation. In addition to validity at the material level, a crucial feature of a constitutive model is the ... [more ▼]

The research aims at developing a new multiaxial constitutive model for concrete in the fire situation. In addition to validity at the material level, a crucial feature of a constitutive model is the applicability at the structural level; yet for concrete in fire there remains a serious lack of models combining reliability and robustness. The theoretical aspects and validation of the new model, which rely on a plastic-damage formulation, have been the subject of a former publication; they are briefly summarized here. This paper explores the capabilities of the concrete model for being used in a performance-based structural fire engineering framework. Several examples of numerical simulations by non-linear finite element method are discussed, with emphasis on practical applications that are demanding for the material model. In particular, it is shown that the simulations using the new concrete model succeed in capturing, at ambient temperature, the crack pattern in a plain concrete specimen and the influence of the loading path on reinforced concrete (RC) slabs. At high temperature, the presented applications include a RC slab subjected to furnace fire and a large-scale composite steel–concrete structure subjected to natural fire. In the numerical analyses, no parameter calibration was required on the particular concrete type, except for the uniaxial strengths and tensile crack energy which are to be defined case-by-case. The results illustrate the reliability and numerical robustness of the model. Also, they suggest that satisfactory prediction of structural behavior in fire can be obtained when no additional data is available on the specific properties of the particular concrete mix that is used in the project, as is often the case in practice, by using standard values of parameters. [less ▲]

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See detailInstitutional Investors, adverse selection and stock market liquidity in France
Sougné, Danielle ULg; Aymen, Ajina; Faten, Lakhal

in International Journal of Managerial Finance (2015), 11

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of ... [more ▼]

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of institutional investors has a positive and significant effect on stock-market liquidity, which confirms the signal theory and trading hypothesis. These investors perform high trading activity which favorably affects market liquidity. The results also show that pension funds improve liquidity. This result suggests that pension funds manage huge assets decreasing transactions costs and improving liquidity. They display a positive signal to the market about more transparency and a low level of information asymmetry. [less ▲]

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See detail"Lire le rythme". Henri Meschonnics Theorie und Praxis des Lesens
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), 41-60

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See detailBiochemical characterisation of the seed oils of four safflower (Carthamus tinctorius) varieties grown in north-eastern of Morocco
Ben Moumen, Abdessamad; Mansouri, Farid; Richard, Gaetan ULg et al

in International Journal of Food Science & Technology (2015)

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi ... [more ▼]

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi-arid region of eastern Morocco) was evaluated through analysis of their phenolic and carotenoid contents. The composition of the phenolic compounds of safflower oil has not yet been documented. Therefore, in this preliminary study, Thirty different phenolic compounds were identified, and significant differences between the oil varieties were observed (P < 0.05). In the seed oil from the Rancho and Sharda safflower varieties, the main phenolic compound was trans-chalcone, representing 13.45% and 11.8%, respectively, of the total phenolics, whereas in Cartamar and Cartafri oils, naringin accounted for 26.82% and 16.5%, respectively, of the total phenolics. The total carotenoid contents ranged from 1.13 mg/kg (Rancho) to 1.34 mg/kg (Cartamar and Cartafri).We observed that b-cryptoxanthin (0.31–0.37 mg/kg) and b-carotene (0.3–0.35 mg/kg) were the predominant carotenoids in all of the safflower oils that were studied. [less ▲]

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See detailOptimal propellantless rendez-vous using differential drag
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Acta Astronautica (2015), 109

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us ... [more ▼]

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us to turn the often-undesired drag perturbation into a control force for relative motion, differential drag is among the most promising propellantless techniques for low-Earth orbiting satellites. An optimal control approach to the problem of orbital rendez-vous using differential drag is proposed in this paper. Thanks to the scheduling of a reference maneuver by means of a direct transcription, the method is flexible in terms of cost function and can easily account for constraints of various nature. Considerations on the practical realization of differential-drag-based maneuvers are also provided. The developments are illustrated by means of high-fidelity simulations including coupled 6-degree-of-freedom simulations and an advanced aerodynamic model. [less ▲]

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See detailThe impact of transport policies on railroad intermodal freight competitiveness – The case of Belgium
Santos, Bruno F.; Limbourg, Sabine ULg; Carreira, Joana Silva

in Transportation Research. Part D : Transport and Environment (2015), 34

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist ... [more ▼]

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist in subsidizing intermodal transport operations (such as in Belgium, to stimulate rail transport), internalizing external costs (as recommended by the European Union in order to foster cleaner modes), and adopting a system perspective when optimizing the location of inland intermodal terminals. The study proposes an innovative mixed integer intermodal freight location-allocation model based on hub-location theory and deals with non-linear transport costs in order to replicate economies of distance. Our analysis suggests that subsidizing has a significant impact on the volumes transported by intermodal transport, and, to a lesser extent, that optimizing terminal location increases the competitiveness of intermodal transport. On the other hand, according to our assumptions, internalizing external costs can negatively impact the promotion of intermodality. This finding indicates that innovative last-mile transports are needed in order to reduce the external impacts of drayage operations. [less ▲]

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See detailConstruire des savoirs sur l'activité de lecture afin de développer les compétences des élèves en difficulté : l'inaccessible rêve?
De Croix, Séverine ULg; Ledur, Dominique

in Education & Formation (2015), e-302

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La ... [more ▼]

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La réflexion qui suit s’inscrit dans le cadre des travaux relatifs aux enseignements adaptés à la prise en charge de ces déficits. Des dispositifs visant à développer la métacognition en lecture, à construire des savoirs sur cette activité et à mieux se percevoir en tant que lecteur ont été conçus, expérimentés et analysés dans le cadre d’une recherche-action longitudinale de type qualitatif. Cet article décrit quelques effets de ces dispositifs, qui encouragent à poursuivre sur la voie de ces interventions à dimension métacognitive dans des recherches à plus large échelle. [less ▲]

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See detailNghiên cứu và thiết kế hai kiểu chuồng nuôi nhông cát Leiolepis guttata (Cuvier, 1829) phù hợp với điều kiện nuôi và vốn đầu tư tại huyện Bắc Bình, tỉnh Bình Thuận
Tran, Tinh ULg; Tran, Ngoc Nguyen Kim Dieu; Vo, Kim Thong et al

in Journal of Agriculture Sciences and Technology (2015), 1/2014

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan ... [more ▼]

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan province) is considered as a fortuitous discovery which was the initiator of the current expanding trend of its rearing. Because L. guttata is a wild animal, with strong disease resistance and adaptation capacity, livestock farmers are presently not very interested in important aspects: rearing techniques, enclosure’s types, sex ratio, diseases’ prevention, etc. Notably the building of enclosures not perfectly suitable breeds a noticeable loss of the number of lizards and a reduction in the profits for the farmers. To this end, the building of two types of enclosures adapted to local rearing conditions and the investing capital available in Bac Binh district, Binh Thuan province is presently essential. We descrite two types of enclosure: the first one surrounded by a bricks (or breeze blocks) wall, the second one fended by a fiber cement corrugated sheets wall. Moreover, we suggest to introduce plants in order to build a vegetal cover nearer to the natural environment of L. guttata: shrubs and a plant carpet becoming the preferential refuge area of the spotted butterfly lizard. [less ▲]

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See detailStephen Jay Gould ou la science enchantée
Jacquemain, Marc ULg

in Politique : Revue de Débats (2015), 88

Stephen Jay Gould, inventeur de la "théorie des équilibres ponctués" avec Nils Elredge fut non seulement un paléontologue de premier plan mais aussi un défenseur acharné du darwinisme. Défenseur acharné ... [more ▼]

Stephen Jay Gould, inventeur de la "théorie des équilibres ponctués" avec Nils Elredge fut non seulement un paléontologue de premier plan mais aussi un défenseur acharné du darwinisme. Défenseur acharné, mais dénué de tout dogmatisme il s'est aussi battu pour une conception "humaniste" de la science, qui l'éloigne de tout scientisme et qui l'amène souvent à "réhabiliter les vaincus" de l'histoire des sciences. Enfin, s'il fut un défenseur de Darwin, il a combattu ceux de successeurs qui ont essayé de l'utiliser pour défendre l'inégalité sociale ou l'eugénisme. En cela Gould fut sans doute le meilleur des darwiniens. [less ▲]

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See detailMirabel: An integrated project for risk and cost/benefit analysis of peanut allergy
Crépet, A.; Papadopoulos, A.; Elegbede, C.F. et al

in Regulatory Toxicology & Pharmacology [=RTP] (2015), 71

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on ... [more ▼]

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on exposure components such as the allergens present in foods and the consumption behaviour of allergic consumers and models to estimate the related risk need to be enriched. Mirabel proposes for the first time studying each risk component using an integrated approach in order to improve the quality of life of the allergic population. Field surveys were conducted in order to fill in the current gaps in unintentional allergen traces in food, allergic consumers’ food behaviour, threshold doses of allergic reaction, allergy symptoms and severity. The aim is also to propose methodological and operational tools to quantify allergic risk, to test management scenarios and to produce a cost/benefit analysis. Medical data on the peanut allergies of 785 patients were collected in the MIRABEL survey and 443 patients answered the food consumption questionnaire. The population surveyed was mostly paediatric – 86% were children under 16 years of age, with a high percentage of males (60%). This project will generate tangible results on peanut allergen exposure and risk which could be used in future risk assessment work and particularly to provide science-based guidance to set up concentration limits for peanut traces on packages. [less ▲]

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See detailRéinventer le rythme / Den Rhythmus neu denken
Viehöver, Vera ULg; Dupont, Bruno

in Intervalles (2015), 7(2015), 170

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See detailProbiotics: an update
Vandenplas, Yvan; Huys, Geert; Daube, Georges ULg

in Jornal de Pediatria (2015), 1

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent ... [more ▼]

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children. Sources: Relevant literature from searches of PubMed, CINAHL, and recent consensus statements were reviewed. Summary of the findings: While a balanced microbiome is related to health, an imbalanced microbiome or dysbiosis is related to many health problems both within the gastro-intestinal tract, such as diarrhea and inflammatory bowel disease, and outside the gastro-intestinal tract such as obesity and allergy. In this context, a strict regulation of probiotics with health claims is urgent, because the vast majority of these products are commercialized as food (supplements), claiming health benefits that are often not substantiated with clinically relevant evidence. The major indications of probiotics are in the area of the prevention and treatment of gastrointestinal related disorders, but more data has become available on extra-intestinal indications. At least two published randomized controlled trials with the commercialized probiotic product in the claimed indication are a minimal condition before a claim can be sustained. Today, Lactobacillus rhamnosus GG and Saccharomyces boulardii are the best-studied strains. Although adverse effects have sporadically been reported, these probiotics can be considered as safe. Conclusions: Although regulation is improving, more stringent definitions are still required. Evidence of clinical benefit is accumulating, although still missing in many areas. Misuse and use of products that have not been validated constitute potential drawbacks. [less ▲]

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See detailA review of gliptins for 2014.
Scheen, André ULg

in Expert opinion on pharmacotherapy (2015), 16(1), 43-62

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a personalized medicine in patients with Type 2 diabetes. Areas covered: An updated review providing an analysis of available recent data with commercialized DPP-4 inhibitors, with a special focus on: differences between the various molecules, novelties regarding their mechanism of action, clinical efficacy in mono- and various combined therapies, comparison with other new therapies, efficacy-safety profile in at risk patients, concern about pancreatic safety, perspectives in cardiovascular prevention and, finally, a selection of remaining unanswered important questions for the clinician. Expert opinion: DPP-4 inhibitors offer various advantages when compared to other glucose-lowering agents. Despite they have been commercialized since a few years only, available data obtained in randomised controlled trials are of better quality compared to those available with ancient classical glucose-lowering agents, especially in more fragile populations such as elderly people, individuals with renal impairment or at high cardiovascular risk and patients at higher risk of hypoglycaemia. However, there remain uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experience combined with a careful post-marketing surveillance. [less ▲]

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See detailPurification and identification of novel antioxidant peptides from enzymatic hydrolysate of chickpea (Cicer arietinum L.) protein concentrate
Ghribi, Abir Mokni; Sila, Assaâd; Przybylski, Rémi et al

in Journal of functional foods (2015), 12

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher ... [more ▼]

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher antioxidant activity than CP. This hydrolysate was fractionated by size exclusion chromatography on a Sephadex G-25 into four major fractions (Fra.I, Fra.II, Fra.III, and Fra.IV). Fraction III, which exhibited the highest DPPH scavenging activity (54% at 1 mg/ml), was then fractionated by reversed-phase high performance liquid chromatography (RP-HPLC). Eleven antioxidant fractions were isolated and two peptide subfractions show antioxidant activity (P3 and P8). The P8 displayed the highest DPPH radicalscavenging activity (67%; at 200 g/ml) among these peptides subfractions. The molecular masses and amino acids sequences of the purified peptides were determined using ESIMS and ESIMS/MS, respectively. Their structures were identified as Asp-His-Gly and Val- Gly-Asp-Ile. These peptides did not show haemolytic activity towards bovine erythrocytes. The results suggest that CPH are good source of natural antioxidants. [less ▲]

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See detailBiodiversity and seasonal variations of zooneuston in the northwestern Mediterranean Sea
Collard, France ULg; Collignon, Amandine ULg; Hecq, Jean-Henri ULg et al

in Belgian Journal of Zoology (2015), 145(1), 40-48

Neuston includes animals and plants inhabiting the surface layer of the water column. The neustonic area is an accumulation zone for bacteria, organic molecules but also terrestrial debris. The surface ... [more ▼]

Neuston includes animals and plants inhabiting the surface layer of the water column. The neustonic area is an accumulation zone for bacteria, organic molecules but also terrestrial debris. The surface layer is also the air/water exchange region. Therefore, neustonic organisms are directly exposed to several constraints such as wind stress and turbulence. The present study aims to characterize the zooneuston in terms of abundance and biodiversity and to evaluate the impacts of wind stress on neustonic abundance. Zooneustonic and zooplanktonic (depth of 5 meters) samples were collected twice a month between 30th August 2011 and 10th July 2012 in Calvi Bay, Corsica. Zooneustonic biodiversity was high and, notably, twenty-eight copepod genera were identified. Among these copepods, several organisms, belonging to the Pontellidae family, were much more frequent in neuston than in underlying plankton and their abundance depended on wind direction. Taxon-specific trends in seasonal abundance variation were present. For example, individuals of the Acantharia Lithoptera spp. were found in summer whereas the Pontellidae Anomalocera patersoni appeared in winter. Overall, our data provide a first step towards a better knowledge of neuston community structure in the Mediterranean Sea. [less ▲]

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See detailLes Phénomènes
Dewalque, Arnaud ULg; Seron, Denis ULg

in Philosophie (2015), 124

Le présent numéro thématique explore quelques aspects de la question de la phénoménalité. Les trois premiers textes portent sur les phénomènes sensibles: sur le nombre des sens (Brentano), le traitement ... [more ▼]

Le présent numéro thématique explore quelques aspects de la question de la phénoménalité. Les trois premiers textes portent sur les phénomènes sensibles: sur le nombre des sens (Brentano), le traitement des phénomènes sensibles dans la phénoménologie de Husserl (Stumpf) et l'héritage du phénoménisme de Mach dans le néokantisme de Natorp (Palette). Les contributions suivantes s’inscrivent dans le cadre du débat contemporain sur la conscience phénoménale. Elles discutent la pertinence et les difficultés d’une approche phénoménologique du monde (Uriah Kriegel), de l’intentionnalité (Dan Zahavi) et du mental (Dewalque & Seron). [less ▲]

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See detailFive-spring model for complete shear behaviour of deep beams
Mihaylov, Boyan ULg

in Structural Concrete (2015), 16(1), 71-83

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear ... [more ▼]

This paper presents a five-spring model capable of predicting the complete pre- and post-peak shear behaviour of deep beams. The model stems from a two-parameter kinematic theory (2PKT) for the shear strength and displacement capacity of deep beams under single curvature. Four of the springs of the model represent the shear resistance mechanisms of the beam, while the fifth spring models the flexural behaviour. The model predicts not only the load–displacement response, but also the deformation patterns of the beam and how these patterns change with increasing load. Validation studies are performed by using 28 tests from the literature, showing excellent results. The model is used to interpret the tests and to draw conclusions about the behaviour of deep beams. It is shown that shear strength variations of up to 60 % between nominally identical specimens can be caused by variations in the path of the critical shear cracks. It is also demonstrated that loss of bond of large reinforcing bars increases the shear capacity of deep beams. Finally, the five-spring model is shown to predict the post-peak shear behaviour effectively, which is important for the analysis of structures under extreme loading. [less ▲]

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See detailCircadian and circannual variations in cord blood hematopoietic cell composition
Servais, Sophie ULg; BAUDOUX, Etienne ULg; Brichard, B. et al

in Haematologica (2015), 100(1), 32-34

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See detailChine, une mise à jour
Florence, Eric ULg

in Politique : Revue de Débats (2015), 88

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois ... [more ▼]

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois. L’argument le plus souvent évoqué était celui d’un décalage insoutenable entre réformes économiques – qui connaîtront un approfondissement à l’occasion du fameux « voyage dans le Sud » de Deng Xiaoping en 1992 – et l’absence de réformes politiques, un décalage qui devait presque immanquablement signifier la fin du régime communiste. Quelque vingt-cinq ans plus tard, où en est-on ? [less ▲]

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See detailReview of Transnational Migration
Munos, Delphine ULg

in South Asian Diaspora (2015), 7(1), 63-65

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See detailInfluence of sugar beet pulp on feeding behavior, growth performance, carcass quality and gut health of fattening pigs.
Laitat, Martine ULg; Antoine, Nadine ULg; Cabaraux, Jean-François ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 20-31

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See detailModave/Vierset-Barse : campagne de fouilles 2013 sur le site de "Rocher du Vieux-Château" à Pont-de-Bonne
Lucon, Yorick; Schaus, Amandine; Delye, Emmanuel ULg

in Chronique de l'Archéologie Wallonne (2015), 22

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See detailComplete analytical procedure to assess the response of a frame submitted to a column loss
Huvelle, Clara; Hoang, Van Long ULg; Jaspart, Jean-Pierre ULg et al

in Engineering Structures (2015), 86

The present paper gives a global overview on recent developments performed at the University of Liege on structural robustness of buildings for the specific scenario ‘‘loss of a column’’. In particular, a ... [more ▼]

The present paper gives a global overview on recent developments performed at the University of Liege on structural robustness of buildings for the specific scenario ‘‘loss of a column’’. In particular, a complete analytical method to assess the response of a 2D frame losing statically one of its columns is presented in details. This method is based on the development of alternative load paths in the damaged structure and takes into account the couplings between the different parts of the structure which are differently affected by the column loss. Also, the validation of the developed method through comparison to experimental and numerical evidences is presented. [less ▲]

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See detailSingle-Walled Metal–Organic Nanotube Built from a Simple Synthon
Adarsh, Nayarassery; Dirtu, Marinela; Naik, Anil et al

in Chemistry : A European Journal (2015), 21

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See detailBiological control in the microbiome era: Challenges and opportunities
Massart, Sébastien ULg; Martinez-Medina, Margarita; Jijakli, Haissam ULg

in Biological Control (2015), 89

Biocontrol research has long been focused on the study of single strains of biocontrol agents (BCAs) and on their interaction with pathogens and host plants. Further focus on plant-associated microbial ... [more ▼]

Biocontrol research has long been focused on the study of single strains of biocontrol agents (BCAs) and on their interaction with pathogens and host plants. Further focus on plant-associated microbial communities was suggested several years ago, but significant advances only occurred recently. The advent of high-throughput sequencing (or next-generation sequencing – NGS) technologies is now driving a paradigm change that allows researchers to integrate microbial community studies into the traditional biocontrol approach. This integration could answer old scientific questions, and will raise new biocontrol hypotheses. Microbial communities could impact disease control through their interaction with host plants, pathogens, and BCAs. A better understanding of these interactions will provide unexpected opportunities to develop innovative biocontrol methods against plant pathogens. For example, formulation or timing of BCA application can be improved, ‘‘helper’’ microbial strains can be selected, or molecules driving the microbiota to a pathogen-resistant composition (‘‘prebiotic’’ approach) can be developed. The five main challenges of microbiome implementation in biocontrol research are also described, i.e. (i) the management of technical errors and biases, (ii) the growing importance of bioinformatics, (iii) the adaptation of experimental schemes, (iv) the appropriate interplay between NGS and other technologies, and (v) the need to complete current genome databases [less ▲]

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See detailAre Children Conservative, Liberal or Metacognitive? Preliminary Evidence for the Involvement of the Distinctiveness Heuristic in Decision Making
Geurten, Marie ULg; Willems, Sylvie ULg; Meulemans, Thierry ULg

in Journal of Experimental Child Psychology (2015), 132

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children ... [more ▼]

The present experiment investigates whether young children are able to reduce their false recognition rate after distinctive encoding by implementing a strategic metacognitive rule. Seventy-two children, aged 4, 6, and 9 years, studied two lists of unrelated items. One of these lists was visually displayed (picture condition) while the other was presented auditorily (word condition). After each study phase, participants completed recognition tests. Finally, they answered questions about their explicit knowledge of the distinctive-encoding effect. The results revealed that even the youngest children in our sample showed a smaller proportion of intrusions in the picture condition than in the word condition. Furthermore, the results of the signal detection analyses were consistent with the hypothesis that the lower rate of false recognitions after picture encoding results from the implementation of a conservative response criterion based on metacognitive expectations (distinctiveness heuristic). Moreover, the absence of correlation between children’s explicit knowledge of the distinctiveness rule and their effective use of this metacognitive heuristic seems to indicate that its involvement in memory decisions could be mediated by implicit mechanisms. [less ▲]

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See detailDeficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Onclinx, Cecile; Dogne, Sophie; Jadin, Laurence et al

in Haematologica (2015)

Hyaluronan is a major component of the extracellular matrix and glycocalyx. Its main somatic degrading enzymes are the hyaluronidases 1 and 2, none of which is active in the bloodstream. We generated ... [more ▼]

Hyaluronan is a major component of the extracellular matrix and glycocalyx. Its main somatic degrading enzymes are the hyaluronidases 1 and 2, none of which is active in the bloodstream. We generated hyaluronidase 2 deficient mice. They suffer from mild chronic anemia and thrombocytopenia, in parallel with a 10-fold increase in plasma hyaluronan concentration. The current study explores the mechanism of these hematological anomalies. The decreased erythrocyte and platelet counts were assigned to peripheral consumption. The erythrocyte half-life was reduced from 25 to 8 days without signs of premature aging. Hyaluronidase 2 deficient platelets were functional. Major intrinsic defects in erythrocyte membrane or stability, as well as detrimental effects of high hyaluronan levels on erythrocytes, were ruled out in vitro. Normal erythrocytes transfused into hyaluronidase 2 deficient mice were quickly destroyed but neither splenectomy nor anti-C5 administration prevented from chronic hemolysis. Schistocytes were present in hyaluronidase 2 deficient smears at a level of 1 to 6%, while virtually absent in control mice. Hyaluronidase 2 deficient mice had increased markers of endothelial damage and microvascular fibrin deposition, without renal failure, accumulation of ultra-large multimers of von Willebrand factor, deficiency of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 motifs, member 13 (ADAMTS13), or hypertension. There was no sign of structural damage in hepatic or splenic sinusoids, or in any other microvessels. We conclude that hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice. The link between this uncommon condition and hyaluronidase 2 remains to be explored in man. [less ▲]

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See detailInfluence of mouse strain on ovarian tissue recovery after engraftment with angiogenic factor.
Fransolet, Maïté ULg; Henry, Laurie ULg; Labied, Soraya et al

in Journal of Ovarian Research (2015), 8(1), 14

BACKGROUND: For women facing gonadotoxic treatment, cryopreservation of ovarian tissue with subsequent retransplantation during remission is a promising technique for fertility preservation. However ... [more ▼]

BACKGROUND: For women facing gonadotoxic treatment, cryopreservation of ovarian tissue with subsequent retransplantation during remission is a promising technique for fertility preservation. However, follicle loss within grafted ovarian tissue can be caused by ischemia and progressive revascularization. Several xenograft models using different immunodeficient rodent lines are suitable for studying ovarian tissue survival and follicular viability after frozen-thawed ovarian cortex transplantation. SCID mice, which are deficient for functional B and T cells, are the most commonly used mice for ovarian xenograft studies. However, due to incomplete immunosuppression, NOD-SCID mice displaying low NK cell function and an absence of circulating complement might be more appropriate. The present study aims to define the most appropriate immunodeficient mouse strain for ovarian tissue xenotransplantation by comparing ovarian graft recovery in SCID and NOD-SCID mice following engraftment in the presence of isoform 111 of vascular endothelial growth factor. METHODS: Sheep ovarian cortex fragments were embedded in a collagen matrix, with or without VEGF111, before being stitched onto the ovaries of SCID and NOD-SCID mice. Transplants were recovered after 3 days to study early revascularization or after 3 weeks to evaluate follicle preservation and tissue fibrosis through histological analyses. RESULTS: At day 3, vessels were largely reorganized in the ovarian grafts of both mouse strains. After 3 weeks, the cortical tissue was clearly identifiable in SCID mice but not in NOD-SCID mice. Upon VEGF111 treatment, vascularization was significantly improved 3 days after transplantation in SCID mice. This increase in vessel density was correlated with better follicular preservation in SCID mice 3 weeks after transplantation. Fibrosis was not decreased by VEGF treatment in either mouse strain. CONCLUSIONS: Tissue architecture and follicular morphology were better preserved in ovarian tissues grafted in SCID mice in comparison with NOD-SCID mice. Moreover, tissue revascularization was improved in SCID mice by VEGF111 graft treatment. Thus, we consider SCID mice to be the best murine model for studying ovarian tissue xenografts. [less ▲]

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See detailPlant polysaccharides initiate underground crosstalk with bacilli by inducing synthesis of the immunogenic lipopeptide surfactin
Debois, Delphine ULg; Fernandez, O.; Franzil, Laurent ULg et al

in Environmental Microbiology Reports (2015), 7(3), 570-582

Some plant-associated bacteria such as Bacillus sp. can protect their host from pathogen ingress and this biocontrol activity correlates with their potential to form multiple antibiotics upon in vitro ... [more ▼]

Some plant-associated bacteria such as Bacillus sp. can protect their host from pathogen ingress and this biocontrol activity correlates with their potential to form multiple antibiotics upon in vitro growth. However, our knowledge on antibiotic production by soil bacilli evolving on roots in natural conditions is still limited. In this work, antibiome imaging first revealed that the lipopeptide surfactin is the main bacterial ingredient produced in planta within the first hours of interaction with root tissues. We further demonstrated that surfactin synthesis is specifically stimulated upon perception of plant cell wall polymers such as xylan or arabinogalactan, leading to fast accumulation of micromolar amounts in the root environment. At such concentrations, the lipopeptide may not only favour the ecological fitness of the producing strain in term of root colonization, but also triggers systemic resistance in the host plant. This surfactin-induced immunity primes the plant to better resist further pathogen ingress, and involves only limited expression of defence-related molecular events and does not provoke seedling growth inhibition. By contrast with the strong response mounted upon perception of pathogens, this strongly attenuated defensive reaction induced by surfactin in plant tissues should help Bacillus to be tolerated as saprophytic partner by its host. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd. [less ▲]

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See detailFaire la guerre, faire l’État. Les officiers « militaires » sous les trois premiers souverains Valois de Naples
Masson, Christophe ULg

in Mélanges de l'Ecole française de Rome. Moyen-Age (2015), CXXVII(I),

From Louis Ist to René Ist, the Valois dukes of Anjou tried to establish their power on the kingdom of Naples. The former had indeed been adopted by Jeanne Ist, the last queen of the Capetian dynasty. The ... [more ▼]

From Louis Ist to René Ist, the Valois dukes of Anjou tried to establish their power on the kingdom of Naples. The former had indeed been adopted by Jeanne Ist, the last queen of the Capetian dynasty. The Valois dukes led several military expeditions to establish their power in Naples, facing the rivalry of the Anjou-Duras and then of the Aragon dynasty. These armies would later on constitute the framework of the Valois’s local administration in Italy. This paper will examine how the three first dukes of Anjou exerted military power. On the one hand, the smaller military responsibilities—exerted on a limited geographical area—were most of the time entrusted to Neapolitean subjects. On the other hand, the officers in charge of the conduct of armies and of the strongholds close to the prince (castles or province of residence) turned out to be most of the time entrusted to foreigners. In sum, the balance of power between the local feudal lords and the duke of Anjou drew the military structures of the royal power; and each of the parties found there its own interest. [less ▲]

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See detailQuantity and spatial distribution of seeds dispersed by a western lowland gorilla population in south-east Cameroon
Petre, Charles-Albert ULg; Tagg, Nikki; Beudels-Jamar et al

in Journal of Tropical Ecology (2015)

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See detailSimulation-based study comparing multiple imputation methods for non-monotone missing ordinal data in longitudinal settings
Donneau, Anne-Françoise ULg; Mauer, Murielle; Lambert, Philippe ULg et al

in Journal of Biopharmaceutical Statistics (2015), 25(03), 570-601

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the ... [more ▼]

The application of multiple imputation (MI) techniques as a preliminary step to handle missing values in data analysis is well established. The MI method can be classified into two broad classes, the joint modeling and the fully conditional specification approaches. Their relative performance for the longitudinal ordinal data setting under the missing at random (MAR) assumption is not well documented. This paper intends to fill this gap by conducting a large simulation study on the estimation of the parameters of a longitudinal proportional odds model. The two MI methods are also illustrated in quality of life data from a cancer clinical trial. [less ▲]

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See detailWestern lowland gorilla seed dispersal: Are seeds adapted to long gut retention times?
Petre, Charles-Albert ULg; Tagg, Nikki; Beudels-Jamar, Roseline et al

in Acta Oecologica: International Journal of Ecology (2015)

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See detailThe age of river-transported carbon: A global perspective
Marwick, Trent R.; Tamooh, Fredrick; Teodoru, Cristian R. et al

in Global Biogeochemical Cycles (2015), 29(2), 122--137

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of ... [more ▼]

The role played by river networks in regional and global carbon (C) budgets is receiving increasing attention. Despite the potential of radiocarbon measurements (Δ14C) to elucidate sources and cycling of different riverine C pools, there remain large regions for which no data are available and no comprehensive attempts to synthesize the available information and examine global patterns in the 14C content of different riverine C pools. Here we present new 14C data on particulate and dissolved organic C (POC and DOC) from six river basins in tropical and subtropical Africa and compiled >1400 literature Δ14C data and ancillary parameters from rivers globally. Our analysis reveals a consistent pattern whereby POC is progressively older in systems carrying higher sediment loads, coinciding with a lower organic carbon content. At the global scale, this pattern leads to a proposed global median Δ14C signature of −203‰, corresponding to an age of ~1800 years B.P. For DOC exported to the coastal zone, we predict a modern (decadal) age (Δ14C = +22 to +46‰), and paired data sets confirm that riverine DOC is generally more recent in origin than POC—in contrast to the situation in ocean environments. Weathering regimes complicate the interpretation of 14C ages of dissolved inorganic carbon, but the available data favor the hypothesis that in most cases, more recent organic C is preferentially mineralized. [less ▲]

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See detailUse of wheat bran arabinoxylans in chitosan-based films: Effect on physicochemical properties
Costa, Maria J.; Cerqueira, Miguel A.; Ruiz, Héctor A. et al

in Industrial Crops and Products (2015), 66

tThe aim of this work was to evaluate physicochemical properties of chitosan-based films with differentfractions of arabinoxylans (AXs). Five fractions composed by AXs or mixtures of AXs and arabino-xylo ... [more ▼]

tThe aim of this work was to evaluate physicochemical properties of chitosan-based films with differentfractions of arabinoxylans (AXs). Five fractions composed by AXs or mixtures of AXs and arabino-xylo-oligosaccharides (AXOS) obtained through three different processes were added to chitosan-based films.These films were obtained by solvent casting and characterized in terms of water vapor permeability(WVP), opacity, thickness, moisture content and mechanical properties (i.e., tensile strength – TS andelongation at break – EB), being the chemical interactions evaluated by FTIR.Moisture content values ranged between 20 and 30% for all five studied films being the lowest valueobserved for chitosan films with the fraction F1 of AX/AXOS (21.1%). The films with incorporation of F3a,F3b and F4 AXs fraction were more opaque (>10%) than the other studied films. Regarding mechanicalproperties CH films presented EB and TS values of 31.26% and 8.25 MPa, respectively, both these valuesremain statistically equal with the incorporation of AX/AXOS except for films containing the fractionF1 and F2. For films with the F2 fraction were obtained higher values of EB (41.31%) while for CH filmscontaining the F1 fraction the TS values (13.07 MPa) increased.In conclusion, wheat bran AXs can be successfully incorporated into chitosan-based edible films pro-viding, together with chitosan, an extra functional value to films, due their health benefits. [less ▲]

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See detailThe Impact of Attentional Allocation Capacities on Nonword Repetition in Children with Specific Language Impairment
Leclercq, Anne-Lise ULg; Maillart, Christelle ULg; Lange, Manon et al

in Clinical Linguistics & Phonetics (2015)

This study aimed at directly assessing the hypothesis that attentional allocation capacity influences poor NWR performances in children with SLI, using an attention demanding visual search task given ... [more ▼]

This study aimed at directly assessing the hypothesis that attentional allocation capacity influences poor NWR performances in children with SLI, using an attention demanding visual search task given concurrently with the NWR task. Twenty-one children with SLI, 21 typically-developing children matched on age, and 21 typically-developing children matched on nonword span performed an immediate serial recall task of nonwords. The nonword lists were presented either alone or concurrently with the visual search task. Overall, results revealed a resource-sharing trade-off between the two tasks. Children with SLI were affected to the same extent as their span-matched controls by the necessity to allocate their attentional resources between the two tasks. Interestingly, nonword processing strategies seemed to differ among groups: age-matched controls allocated a larger part of their attentional resources to the encoding stage, while nonword recall was more attention demanding in children with SLI and younger controls. [less ▲]

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See detailModulating effect of COMT Val158Met polymorphism on interference resolution during a working memory task
Jaspar, Mathieu ULg; DIDEBERG, Vinciane ULg; Bours, Vincent ULg et al

in Brain & Cognition (2015), 95

Genetic variability related to the catechol-O-methyltransferase (COMT) gene has received increasing attention in the last 15 years, in particular as a potential modulator of the neural substrates ... [more ▼]

Genetic variability related to the catechol-O-methyltransferase (COMT) gene has received increasing attention in the last 15 years, in particular as a potential modulator of the neural substrates underlying inhibitory processes and updating in working memory (WM). In an event-related functional magnetic resonance imaging (fMRI) study, we administered a modified version of the Sternberg probe recency task (Sternberg, 1966) to 43 young healthy volunteers, varying the level of interference across successive items. The task was divided into two parts (high vs. low interference) to induce either proactive or reactive control processes. The participants were separated into three groups according to their COMT Val158Met genotype [Val/Val (VV); Val/Met (VM); Met/Met (MM)]. The general aim of the study was to determine whether COMT polymorphism has a modulating effect on the neural substrates of interference resolution during WM processing. Results indicate that interfering trials were associated with greater involvement of frontal cortices (bilateral medial frontal gyrus, left precentral and superior frontal gyri, right inferior frontal gyrus) in VV homozygous subjects (by comparison to Met allele carriers) only in the proactive condition of the task. In addition, analysis of peristimulus haemodynamic responses (PSTH) revealed that the genotype-related difference observed in the left SFG was specifically driven by a larger increase in activity from the storage to the recognition phase of the interfering trials in VV homozygous subjects. These results confirm the impact of COMT genotype on inhibitory processes during a WM task, with an advantage for Met allele carriers. Interestingly, this impact on frontal areas is present only when the level of interference is high, and especially during the transition from storage to recognition in the left superior frontal gyrus. [less ▲]

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See detailDéveloppements récents de l'assurance construction en droit européen
Kohl, Benoît ULg

in Revue trimestrielle de droit immobilier (2015), 1

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See detailSoluble factors regulated by epithelial-mesenchymal transition mediate tumour angiogenesis and myeloid cell recruitment.
Suarez-Carmona, Meggy ULg; Bourcy, Morgane ULg; LESAGE, J et al

in Journal of Pathology (The) (2015)

Epithelial-to-mesenchymal transition (EMT) programs provide cancer cells with invasive and survival capacities that might favor metastatic dissemination. Whilst signaling cascades triggering EMT have been ... [more ▼]

Epithelial-to-mesenchymal transition (EMT) programs provide cancer cells with invasive and survival capacities that might favor metastatic dissemination. Whilst signaling cascades triggering EMT have been extensively studied, the impact of EMT on the crosstalk between tumor cells and the tumor microenvironment remains elusive. We aimed to identify EMT-regulated soluble factors that facilitate the recruitment of host cells in the tumor. Our findings indicate that EMT phenotypes relate to the induction of a panel of secreted mediators, namely IL-8, IL-6, sICAM-1, PAI-1 and GM-CSF, and implicate the EMT-transcription factor Snail as a regulator of this process. We further show that EMT-derived soluble factors are pro-angiogenic in vivo (in the mouse ear sponge assay), ex vivo (in the rat aortic ring assay) and in vitro (in a chemotaxis assay). Additionally, conditioned medium from EMT-positive cells stimulates the recruitment of myeloid cells. In a bank of 40 triple-negative breast cancers, tumors presenting features of EMT were significantly more angiogenic and infiltrated by a higher quantity of myeloid cells compared to tumors with little or no EMT. Taken together, our results show that EMT programs trigger the expression of soluble mediators in cancer cells that stimulate angiogenesis and recruit myeloid cells in vivo, which might in turn favor cancer spread. [less ▲]

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See detailAssessment of contaminant levels and trophic relations at a World Heritage Site by measurements in a characteristic shorebird species
Schwemmer, Philipp; Covaci, Adrian; Das, Krishna ULg et al

in Environmental Research (2015), 136

The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB ... [more ▼]

The River Elbe is responsible for influxes of contaminants into the Wadden Sea World Heritage Site. We investigated levels of polychlorinated biphenyls (PCBs), oxychlordane (OxC), hexachlorobenzene (HCB), hexachlorocyclohexanes (α-, β-, γ-HCHs), dichlorodiphenyltrichloroethane (DDT) and its metabolites, and polybrominated diphenyl ethers (PBDEs) in blood and feathers from Eurasian oystercatchers (Haematopus ostralegus; n=28) at the Elbe and compared it with a non-riverine site about 90 km further north. (1) Mean levels of all contaminants in feathers and serum were significantly higher at the river (ƩPCBs: 27.6 ng/g feather, 37.0 ng/ml serum; ƩDDTs: 5.3 ng/g feather, 4.4 ng/ml serum) compared with the non-riverine site (ƩPCBs: 6.5 ng/g feather, 1.2 ng/ml serum; ƩDDTs: 1.4 ng/g feather, 0.5 ng/ml serum). Mean ƩHCH and HCB levels were <1.8 ng/g in feather and <1.8 ng/ml in serum at both sites. (2) Levels of most detectable compounds in serum and feathers were significantly related, but levels were not consistently higher in either tissue. (3) There was no significant relationship between trophic level in individual oystercatchers (expressed as δ15N) or the degree of terrestrial feeding (expressed as δ13C) and contaminant loads. (4) PBDEs were not detected in significant amounts at either site. The results of this study indicate that the outflow from one of Europe’s largest river systems is associated with significant historical contamination, reflected by the accumulation of contaminants in body tissues in a coastal benthivore predator. [less ▲]

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See detailTiO2 Macroscopic Fibers with Enhanced Photocatalytic Properties Obtained through a Scale-Up Semi-Industrial Process
Kinadjian, Natacha; Le Bechec, Mickael; Henrist, Catherine ULg et al

in Advanced Engineering Materials (2015), 17(1), 36-44

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See detailChemical composition and functional properties of dietary fibre extracted by Englyst and Prosky methods from the alga Ulva lactuca collected in Tunisia
Yaich, Hela; Garna, Haikel; Bchir, Brahim et al

in Algal Research (2015), 9

Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present ... [more ▼]

Nowadays there is a growing trend to find new sources of dietary fibre (DF), such as marine algae by-products that have traditionally been undervalued. In this respect, the aim of the present investigation was firstly to compare two methods of dietary fibre quantification (Englyst and Prosky) and secondly to determine the chemical composition and some of the functional properties of total and insoluble fibres extracted in accordance with the Englyst method. The dietary fibres of dried Ulva lactuca collected from the Tunisian littoral were determined by the Prosky (gravimetric method) and Englyst (enzymatic-chemical method) methods. The two extraction methods (Englyst–Prosky) provided approximately the same values in total fibres (~54%). However, they had different insoluble and soluble fibre contents. U. lactuca contained 20.53% and 31.55% of soluble fibres and 34.37% and 21.54% of insoluble fibres using the Prosky and Englyst methods, respectively. The fractionation of the insoluble dietary fibre concentrate revealed that hemicellulose was the most abundant fraction (32.49%), followed by cellulose (16.59%) and “lignin-like” compounds (1.53%). For both fibre concentrates, the main neutral sugar was glucose (20.70%–27.59%), which corresponded to hemicellulose and cellulose. The water holding capacity of insoluble fibre concentrate was relatively high. It varied between 9.32 g and 10.3 g of water/g of dry fibre at 25 °C and 80 °C, respectively. Nevertheless, the oil holding capacity of the insoluble fibre concentrate was not affected by temperature. It was about 1.08 and 1.01 g of oil/g of dry fibre at 25 °C and 80 °C. Despite the significant functional properties of fibre concentrate, the presence of lead limits its use as an ingredient in the food industry. [less ▲]

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See detailBifix codes and interval exchanges
Berthé, Valérie; De Felice, Clelia; Dolce, Francesco et al

in Journal of Pure and Applied Algebra (2015), 219(7), 27812798

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See detailA note on the equivalence between observed and expected information functions with polytomous IRT models
Magis, David ULg

in Journal of Educational & Behavioral Statistics (2015), 40

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected ... [more ▼]

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected information functions are equivalent for the class of divide-by-total models (including partial credit, generalized partial credit, rating scale and nominal response models), but not for the class of difference models (including the graded response and modified graded response models). Yet, observed information function remains positive in both classes. Straightforward connections with dichotomous IRT models and further implications are outlined. [less ▲]

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See detailA Membrane-Type-1 Matrix Metalloproteinase (MT1-MMP) - Discoidin Domain Receptor 1 Axis Regulates Collagen-Induced Apoptosis in Breast Cancer Cells.
Assent, Delphine; Bourgot, Isabelle ULg; Hennuy, Benoît ULg et al

in PloS one (2015), 10(3), 0116006

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To ... [more ▼]

During tumour dissemination, invading breast carcinoma cells become confronted with a reactive stroma, a type I collagen-rich environment endowed with anti-proliferative and pro-apoptotic properties. To develop metastatic capabilities, tumour cells must acquire the capacity to cope with this novel microenvironment. How cells interact with and respond to their microenvironment during cancer dissemination remains poorly understood. To address the impact of type I collagen on the fate of tumour cells, human breast carcinoma MCF-7 cells were cultured within three-dimensional type I collagen gels (3D COL1). Using this experimental model, we have previously demonstrated that membrane type-1 matrix metalloproteinase (MT1-MMP), a proteinase overexpressed in many aggressive tumours, promotes tumour progression by circumventing the collagen-induced up-regulation of BIK, a pro-apoptotic tumour suppressor, and hence apoptosis. Here we performed a transcriptomic analysis to decipher the molecular mechanisms regulating 3D COL1-induced apoptosis in human breast cancer cells. Control and MT1-MMP expressing MCF-7 cells were cultured on two-dimensional plastic plates or within 3D COL1 and a global transcriptional time-course analysis was performed. Shifting the cells from plastic plates to 3D COL1 activated a complex reprogramming of genes implicated in various biological processes. Bioinformatic analysis revealed a 3D COL1-mediated alteration of key cellular functions including apoptosis, cell proliferation, RNA processing and cytoskeleton remodelling. By using a panel of pharmacological inhibitors, we identified discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase specifically activated by collagen, as the initiator of 3D COL1-induced apoptosis. Our data support the concept that MT1-MMP contributes to the inactivation of the DDR1-BIK signalling axis through the cleavage of collagen fibres and/or the alteration of DDR1 receptor signalling unit, without triggering a drastic remodelling of the transcriptome of MCF-7 cells. [less ▲]

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