Conclusions: TIGRE is obviously able to detect stellar rotation periods in the CaII H+K emission cores when the time series contains a sufficient number of data points. However, this is frequently not achievable during the wet summer season in Guanajuato. Hence, future estimates of rotation periods will concentrate on stars that are observable during the winter season from October until April. [less ▲]Detailed reference viewed: 21 (2 ULg) Models of the η Corvi Debris Disk from the Keck Interferometer, Spitzer, and HerschelLebreton, J.; Beichman, C.; Bryden, G. et alin Astrophysical Journal (2016), 817Debris disks are signposts of analogs to small-body populations of the solar system, often, however, with much higher masses and dust production rates. The disk associated with the nearby star η Crv is ... [more ▼]Debris disks are signposts of analogs to small-body populations of the solar system, often, however, with much higher masses and dust production rates. The disk associated with the nearby star η Crv is especially striking, as it shows strong mid- and far-infrared excesses despite an age of ∼1.4 Gyr. We undertake constructing a consistent model of the system that can explain a diverse collection of spatial and spectral data. We analyze Keck Interferometer Nuller measurements and revisit Spitzer and additional spectrophotometric data, as well as resolved Herschel images, to determine the dust spatial distribution in the inner exozodi and in the outer belt. We model in detail the two-component disk and the dust properties from the sub-AU scale to the outermost regions by fitting simultaneously all measurements against a large parameter space. The properties of the cold belt are consistent with a collisional cascade in a reservoir of ice-free planetesimals at 133 AU. It shows marginal evidence for asymmetries along the major axis. KIN enables us to establish that the warm dust consists of a ring that peaks between 0.2 and 0.8 AU. To reconcile this location with the ∼400 K dust temperature, very high albedo dust must be invoked, and a distribution of forsterite grains starting from micron sizes satisfies this criterion, while providing an excellent fit to the spectrum. We discuss additional constraints from the LBTI and near-infrared spectra, and we present predictions of what James Webb Space Telescope can unveil about this unusual object and whether it can detect unseen planets. [less ▲]Detailed reference viewed: 8 (1 ULg) The α CrB binary system: A new radial velocity curve, apsidal motion, and the alignment of rotation and orbit axesSchmitt, J. H. M. M.; Schröder, K.-P.; Rauw, Gregor et alin Astronomy and Astrophysics (2016), 586We present a new radial velocity curve for the two components of the eclipsing spectroscopic binary α CrB. This binary consists of two main-sequence stars of types A and G in a 17.3599-day orbit ... [more ▼]We present a new radial velocity curve for the two components of the eclipsing spectroscopic binary α CrB. This binary consists of two main-sequence stars of types A and G in a 17.3599-day orbit, according to the data from our robotic TIGRE facility that is located in Guanajuato, Mexico. We used a high-resolution solar spectrum to determine the radial velocities of the weak secondary component by cross-correlation and wavelength referencing with telluric lines for the strongly rotationally broadened primary lines (v sin(i) = 138 km s[SUP]-1[/SUP]) to obtain radial velocities with an accuracy of a few hundred m/s. We combined our new RV data with older measurements, dating back to 1908 in the case of the primary, to search for evidence of apsidal motion. We find an apsidal motion period between 6600 and 10 600 yr. This value is consistent with the available data for both the primary and secondary and is also consistent with the assumption that the system has aligned orbit and rotation axes. [less ▲]Detailed reference viewed: 24 (6 ULg) Hot Jupiters with relatives: discovery of additional planets in orbit around WASP-41 and WASP-47Neveu-VanMalle, M.; Queloz, D.; Anderson, D. R. et alin Astronomy and Astrophysics (2016), 586We report the discovery of two additional planetary companions to WASP-41 and WASP-47. WASP-41 c is a planet of minimum mass 3.18 $\pm$ 0.20 M$_{\rm Jup}$ and eccentricity 0.29 $\pm$ 0.02, and it orbits ... [more ▼]We report the discovery of two additional planetary companions to WASP-41 and WASP-47. WASP-41 c is a planet of minimum mass 3.18 $\pm$ 0.20 M$_{\rm Jup}$ and eccentricity 0.29 $\pm$ 0.02, and it orbits in 421 $\pm$ 2 days. WASP-47 c is a planet of minimum mass 1.24 $\pm$ 0.22 M$_{\rm Jup}$ and eccentricity 0.13 $\pm$ 0.10, and it orbits in 572 $\pm$ 7 days. Unlike most of the planetary systems that include a hot Jupiter, these two systems with a hot Jupiter have a long-period planet located at only $\sim$1 au from their host star. WASP-41 is a rather young star known to be chromospherically active. To differentiate its magnetic cycle from the radial velocity effect induced by the second planet, we used the emission in the H$\alpha$ line and find this indicator well suited to detecting the stellar activity pattern and the magnetic cycle. The analysis of the Rossiter-McLaughlin effect induced by WASP-41 b suggests that the planet could be misaligned, though an aligned orbit cannot be excluded. WASP-47 has recently been found to host two additional transiting super Earths. With such an unprecedented architecture, the WASP-47 system will be very important for understanding planetary migration. [less ▲]Detailed reference viewed: 49 (4 ULg) Diversity and ecology survey of mosquitoes potential vectors in Belgian equestrian farms: A threat prevention of mosquito-borne equine arbovirusesBoukraa, Slimane ; de la Grandière, Maria Ana ; Bawin, Thomas et alin Preventive Veterinary Medicine (2016), 124Emergence of West Nile Virus was recently recorded in several European countries, which can lead to severe health problems in horse populations. Europe is also at risk of introduction of mosquito-borne ... [more ▼]Emergence of West Nile Virus was recently recorded in several European countries, which can lead to severe health problems in horse populations. Europe is also at risk of introduction of mosquito-borne equine alphavirus from Americas. Prevention of these arboviruses requires a clear understanding of transmission cycles, especially their vectors. To characterize mosquito fauna, their ecology and identify potential vectors of equine arboviruses in Belgium, entomological surveys of six equestrian farms located in the Wolloon Region were conducted during 2011–2012. The harvest of mosquitoes was based on larval sampling (272 samples from 111 breeding sites) and monthly adults trapping (CO2-baited traps, Mosquito Magnet Liberty Plus). Among 51,493 larvae and 319 adult mosquitoes collected, morphological identification showed the presence of 11 species: Anopheles claviger (Meigen), An. maculipennis s.l. (Meigen), An. plumbeus (Stephens), Culex hortensis (Ficalbi), Cx. territans (Walker), Cx. pipiens s.l. L., Cx. torrentium (Martini), Coquillettidia richiardii (Ficalbi), Culiseta annulata (Schrank), Aedes cantans (Meigen), Ae. geniculatus (Olivier). Molecular identification of Cx. pipiens species complex allowed the detection of three molecular forms, Pipiens (92.3%), Molestus (4.6%) and Hybrid (3.1%). Larvae of Cx. pipiens sl and Cx. torrentium were omnipresent and the most abundant species. Water troughs, ponds and slurry (liquid manure) were the most favorable breeding sites of mosquito larvae. Based upon behavior and ecology of the identified mosquito species, Studied Belgian equestrian farms seem to provide a suitable environment and breeding sites for the proliferation of potential vectors of arboviruses and those being a real nuisance problem for horses and neighboring inhabitants. [less ▲]Detailed reference viewed: 38 (8 ULg) New and updated convex shape models of asteroids based on optical data from a large collaboration networkHanuš, J.; Ďurech, J.; Oszkiewicz, D. A. et alin Astronomy & Astrophysics (2016), 586Asteroid modeling efforts in the last decade resulted in a comprehensive dataset of almost 400 convex shape models and their rotation states. This amount already provided a deep insight into physical ... [more ▼]Asteroid modeling efforts in the last decade resulted in a comprehensive dataset of almost 400 convex shape models and their rotation states. This amount already provided a deep insight into physical properties of main-belt asteroids or large collisional families. We aim to increase the number of asteroid shape models and rotation states. Such results are an important input for various further studies such as analysis of asteroid physical properties in different populations, including smaller collisional families, thermophysical modeling, and scaling shape models by disk-resolved images, or stellar occultation data. This provides, in combination with known masses, bulk density estimates, but constrains also theoretical collisional and evolutional models of the Solar System. We use all available disk-integrated optical data (i.e., classical dense-in-time photometry obtained from public databases and through a large collaboration network as well as sparse-in-time individual measurements from a few sky surveys) as an input for the convex inversion method, and derive 3D shape models of asteroids, together with their rotation periods and orientations of rotation axes. The key ingredient is the support of more that one hundred observers who submit their optical data to publicly available databases. We present updated shape models for 36 asteroids, for which mass estimates are currently available in the literature or their masses will be most likely determined from their gravitational influence on smaller bodies, which orbital deflection will be observed by the ESA Gaia astrometric mission. This was achieved by using additional optical data from recent apparitions for the shape optimization. Moreover, we also present new shape model determinations for 250 asteroids, including 13 Hungarias and 3 near-Earth asteroids. [less ▲]Detailed reference viewed: 37 (9 ULg) Diacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEOPavelka, Karel; Bruyère, Olivier ; Cooper, Cyrus et alin Drugs & Aging (2016), 33(2), 75-85Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been ... [more ▼]Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit–risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated [less ▲]Detailed reference viewed: 26 (10 ULg) L'arrêt de mort des (trop) petites circonscriptions électorales wallonnesBouhon, Frédéric in Journal des Tribunaux (2016), 6634Cet article propose un commentaire de l'arrêt n° 169/2015 de la Cour constitutionnelle belge, par lequel elle a considéré que les règles législatives qui instaurent les plus petites circonscriptions ... [more ▼]Cet article propose un commentaire de l'arrêt n° 169/2015 de la Cour constitutionnelle belge, par lequel elle a considéré que les règles législatives qui instaurent les plus petites circonscriptions utilisées pour les élections du Parlement wallon sont inconstitutionnelles. L'article revient sur les enjeux du découpage du territoire en circonscriptions électorales, sur la jurisprudence antérieure en la matière et suggère un certain nombre d'adaptations que le législateur wallon pourrait adopter pour réagir à l'arrêt. [less ▲]Detailed reference viewed: 60 (15 ULg) Traumatologie du rugby à VIIKAUX, Jean-François ; Julia, Marc; Delvaux, François et alin Science & Sports (2016), 31(1), 1-5Aims. — To estimate the risk of injury in rugby sevens.News. — The rugby sevens is an increasingly popular sport since the creation of the IRB SevensWorld Series in 2000 and its introduction as an Olympic ... [more ▼]Aims. — To estimate the risk of injury in rugby sevens.News. — The rugby sevens is an increasingly popular sport since the creation of the IRB SevensWorld Series in 2000 and its introduction as an Olympic sport in 2016. Despite its strong simi-larities to rugby union, it remains a different sport with higher game intensity, causing a moresignificant number of injuries. The average incidence of injury in rugby sevens is 249.27 for1000 hours of play against 102.25 for 1000 hours of rugby union matches.Conclusion. — This epidemiological review of injuries among the rugby sevens refers to theirlocation and their nature, the causes, the position of players, the type of field, as well as thedowntime of practice following trauma. [less ▲]Detailed reference viewed: 76 (23 ULg) Quelques considérations pour adapter nos forêts aux changements climatiquesClaessens, Hugues in Silva Belgica (2016)Au cœur d’une grande forêt naturelle comme celle d’Anlier, de Saint-Hubert ou de Daverdisse, le promeneur ressent souvent une impression de calme et de stabilité. Cela pourrait faire penser que la forêt ... [more ▼]Au cœur d’une grande forêt naturelle comme celle d’Anlier, de Saint-Hubert ou de Daverdisse, le promeneur ressent souvent une impression de calme et de stabilité. Cela pourrait faire penser que la forêt est éternelle et sa forme immuable. Il n’en est rien, ce n’est qu’une question d’échelle temporelle, car depuis toujours, la forêt n’est que changement, dans sa surface, sa structure et sa composition, disparaissant parfois totalement pour recoloniser ensuite l’espace avec d’autres essences. [less ▲]Detailed reference viewed: 9 (2 ULg) Employee Emotional Competence: Construct Conceptualization and Validation of a Customer-Based MeasureDelcourt, Cécile ; Gremler, Dwayne; van Riel, Allard et alin Journal of Service Research (2016), 19(1), 72-87Customers often experience intense emotions during service encounters. Their perceptions of how well contact employees demonstrate emotional competence in emotionally charged service encounters can affect ... [more ▼]Customers often experience intense emotions during service encounters. Their perceptions of how well contact employees demonstrate emotional competence in emotionally charged service encounters can affect their service evaluations and loyalty intentions. Previous studies examining employees’ potential to behave in emotionally competent ways (i.e., employee emotional intelligence [EEI]) have used self- or supervisor-reported scales to predict customer outcomes, presenting EEI as stable and independent of the context. However, service firms should be more concerned with the actual display of emotionally competent behaviors by employees (employee emotional competence [EEC]), because employee behaviors vary across encounters. Moreover, a customer perspective of EEC is useful as customer perceptions of employee performance are crucial predictors of satisfaction and loyalty. Therefore, this study proposes a conceptualization and operationalization of EEC in a service encounter context. On the basis of a comprehensive literature review and in-depth interviews, the authors develop a scale to capture customer-perceived EEC, defined as an employee’s competence in perceiving, understanding, and regulating customer emotions during a discrete service encounter. The scale achieves good reliability and validity. Researchers can use it to explore the role of EEC in service contexts; managers can employ the scale to diagnose EEC and improve customers’ service encounter experiences. [less ▲]Detailed reference viewed: 115 (11 ULg) New perspectives for the design of sustainable bioprocesses for phosphorus recovery from wasteTarayre, Cédric ; De Clercq, Lies; Charlier, Raphaëlle et alin Bioresource Technology (2016), 206Phosphate rock has long been used for the production of phosphorus based chemicals. However, considering the depletion of the reservoirs and the decrease of the quality of phosphate rocks, a potential ... [more ▼]Phosphate rock has long been used for the production of phosphorus based chemicals. However, considering the depletion of the reservoirs and the decrease of the quality of phosphate rocks, a potential market is now emerging for the recovery of phosphate from waste and its reuse for different applications. Notably, phosphate recovery from wastewater could be included in a circular economy approach. This review focuses on the use of microbial systems for phosphorus accumulation and recovery, by considering the actual range of analytical techniques available for the monitoring of phosphorus accumulating organisms, as well as the actual biochemical and metabolic engineering toolbox available for the optimization of bioprocesses. In this context, knowledge gathered from process, system and synthetic biology could potentially lead to innovative process design. [less ▲]Detailed reference viewed: 31 (2 ULg) No favorable effect of reduced tillage on microbial community diversity in a silty loam soil (Belgium)Degrune, Florine ; Theodorakopoulos, Nicolas ; Dufrêne, Marc et alin Agriculture, Ecosystems & Environment (2016), 224Among the soil management practices used to promote sustainable agriculture, reduced tillage and retention of residues from the previous crop are reported to enhance significantly both soil fertility and ... [more ▼]Among the soil management practices used to promote sustainable agriculture, reduced tillage and retention of residues from the previous crop are reported to enhance significantly both soil fertility and crop productivity. Here, high-throughput sequencing (454 technology) was used to see how the tillage regime (conventional vs. reduced tillage) and the fate of crop residues (retention or removal) affect microbial communities at two sampling depths (top soil: 0–5 cm and deeper soil: 15–20 cm) in a fertile silty loam soil in Belgium. All combinations of these three factors were studied. After 6 years of conversion from conventional to reduced tillage, depth emerged as the main factor responsible for variation in microbial diversity, tillage regime ranked second, and finally, crop residue fate had no influence on microbial diversity. For both bacteria and fungi, the diversity appeared higher in the top soil than in the deeper soil, and surprisingly, higher under conventional than under reduced tillage. These differences are explained by changes in community composition due to taxon loss rather than taxon replacement. The specific local set of environmental conditions (a loess-derived soil and an oceanic temperate climate) may explain these results. These observations raise the question: does impoverishment in indicator taxa influence soil processes, and thus crop production? To answer this question, we discuss how the presence of certain indicator taxa liable to play an ecological role might relate to crop productivity. [less ▲]Detailed reference viewed: 53 (28 ULg) Vers un modèle d’apprentissage réflexif. Recueil de traces d’apprentissage formulées dans les log books des stagiaires en médecineVierset, Viviane in Approches Inductives (2016)Detailed reference viewed: 25 (5 ULg) Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing FactorsStankovic, Nancy ; Schloesser, Marie ; Joris, Marine et alin Plant Physiology (2016), 170Serine/Arginine-rich (SR) proteins are essential nucleus-localized splicing factors. Our prior studies showed that Arabidopsis RSZ22, a homolog of the human SRSF7 SR factor, exits the nucleus through two ... [more ▼]Serine/Arginine-rich (SR) proteins are essential nucleus-localized splicing factors. Our prior studies showed that Arabidopsis RSZ22, a homolog of the human SRSF7 SR factor, exits the nucleus through two pathways, either dependent or independent on the XPO1 receptor. Here, we examined the expression profiles and shuttling dynamics of the Arabidopsis SRSF1 subfamily (SR30, SR34, SR34a and SR34b) under control of their endogenous promoter in Arabidopsis and in transient expression assay. Due to its rapid nucleocytoplasmic shuttling and high expression level in transient assay, we analysed the multiple determinants that regulate the localisation and shuttling dynamics of SR34. By site-directed mutagenesis of SR34 RNA-binding sequences and RS domain, we further show that functional RRM1 or RRM2 are dispensable for the exclusive protein nuclear localization and speckle-like distribution. However, mutations of both RRMs induced aggregation of the protein whereas mutation in the RS domain decreased the stability of the protein and suppressed its nuclear accumulation. Furthermore, the RNA-binding motif mutants are defective for their export through the XPO1 (CRM1/Exportin-1) receptor pathway, but retain nucleocytoplasmic mobility. We performed a yeast two hybrid screen with SR34 as bait and discovered SR45 as a new interactor. SR45 is an unusual SR splicing factor bearing two RS domains. These interactions were confirmed in planta by FLIM-FRET and BiFC and the roles of SR34 domains in protein-protein interactions were further studied. Altogether, our report extends our understanding of shuttling dynamics of Arabidopsis SR splicing factors [less ▲]Detailed reference viewed: 61 (25 ULg) COMMENT J'EXPLORE... LA BIPOLARITE EN PEDOPSYCHIATRIE : UNE SEMIOLOGIE DIMENSIONNELLESCHOLL, Jean-Marc in Revue Médicale de Liège (2016), 71(2), 94-100Despite its high frequency, bipolarity in childhood is little understood and is often diagnosed only after several years of development, and this during a time when the child’s psychosocial future is at ... [more ▼]Despite its high frequency, bipolarity in childhood is little understood and is often diagnosed only after several years of development, and this during a time when the child’s psychosocial future is at stake. A proper diagnosis requires recognition of accurate clinical signs. It is therefore essential to furnish clinicians with precise semiological markers. This paper presents a dimensional semiology for use in anamnesis and in clinical observation of the child. These clinical signs enable the identification of a bipolar manic temperament in the child and/or the identification of various different forms of childhood bipolar and depressive disorder. The relevant differential diagnoses and comorbidities are also presented. [less ▲]Detailed reference viewed: 70 (17 ULg) Dynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer CellsTruong, Alice ; Yip, Cassandre ; PAYE, Alexandra et alin FEBS Journal (2016), 283(4), 704-22MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes ... [more ▼]MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes primary tumor growth and lung metastases. Although trafficking and internalization of the transmembrane MT1-MMP have been extensively investigated, little is known about the regulatory mechanisms of the GPI-anchored MT4-MMP. Here, we investigated the fate and cellular trafficking of MT4-MMP by analyzing its homophilic complex interactions, internalization and recycling dynamics compared to an inert form, MT4-MMP-E249A. Oligomeric and dimeric complexes were analyzed by co-transfection of cells with FLAG- or Myc-tagged MT4-MMP by reducing and non-reducing immunoblots and co-immunoprecipitation experiments. The trafficking of MT4-MMP was studied using an antibody feeding assay and confocal microscopy analysis or cell surface protein biotinylation and Western blot analysis. We demonstrate that MT4-MMP forms homophilic complexes at the cell surface, internalizes in early endosomes, and some of the enzyme is either auto-degraded or recycled to the cell surface. Our data indicate that MT4-MMP is internalized by the CLIC/GEEC pathway, a mechanism that differs from other MT-MMP members. Although MT4-MMP localizes with caveolin-1, MT4-MMP internalization was not affected by inhibitors of caveolin-1 or clathrin endocytosis pathways but was reduced by cdc42 or RhoA silencing with siRNA. We provide a new mechanistic insight into the regulatory mechanisms of MT4-MMP, which may have implications in the design of novel therapeutic strategies for metastatic breast cancer. This article is protected by copyright. All rights reserved. [less ▲]Detailed reference viewed: 135 (17 ULg) Mapping of riparian invasive species with supervised classification of Unmanned Aerial System (UAS) imageryMichez, Adrien ; Piégay, Hervé; Lisein, Jonathan et alin International Journal of Applied Earth Observation and Geoinformation (2016), 44Riparian zones are key landscape features, representing the interface between terrestrial and aquatic ecosystems. Although they have been influenced by human activities for centuries, their degradation ... [more ▼]Riparian zones are key landscape features, representing the interface between terrestrial and aquatic ecosystems. Although they have been influenced by human activities for centuries, their degradation has increased during the 20th century. Concomitant with (or as consequences of) these disturbances, the invasion of exotic species has increased throughout the world’s riparian zones. In our study, we propose a easily reproducible methodological framework to map three riparian invasive taxa using Unmanned Aerial Systems (UAS) imagery: Impatiens glandulifera Royle, Heracleum mantegazzianum Sommier and Levier, and Japanese knotweed (Fallopia sachalinensis (F. Schmidt Petrop.), Fallopia japonica (Houtt.) and hybrids). Based on visible and near-infrared UAS orthophoto, we derived simple spectral and texture image metrics computed at various scales of image segmentation (10,30, 45, 60 using eCognition software). Supervised classification based on the random forests algorithm was used to identify the most relevant variable (or combination of variables) derived from UAS imagery for mapping riparian invasive plant species. The models were built using 20% of the dataset, the rest of the dataset being used as a test set (80%). Except for H. mantegazzianum, the best results in terms of global accuracy were achieved with the finest scale of analysis (segmentation scale parameter = 10). The best values of overall accuracies reached 72%, 68%, and 97% for I. glandulifera, Japanese knotweed, and H. mantegazzianum respectively. In terms of selected metrics, simple spectral metrics (layer mean / camera brightness) were the most used. Our results also confirm the added value of texture metrics (GLCM derivatives) for mapping riparian invasive species. The results obtained for I. glandulifera and Japanese knotweed do not reach sufficient accuracies for operational applications. However, the results achieved for H. mantegazzianum are encouraging. The high accuracies values combined to relatively light model-inputs needed (delineation of a few umbels) make our approach a serious contender as a cost-effective tool to improve the field management of H. mantegazzianum. [less ▲]Detailed reference viewed: 91 (29 ULg) Hyaluronic acid and tendon lesionsKaux, Jean-François ; SAMSON, Antoine; Crielaard, Jean-Michel in Muscles, Ligaments and Tendons Journal (2016), 5(4 (eCollection 2015 Oct-Dec)), 264-269Introduction: Recently, the viscoelastic properties of hyaluronic acid on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results ... [more ▼]Introduction: Recently, the viscoelastic properties of hyaluronic acid on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results on hyaluronic acid’s ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function. This literature review analyses studies relating to the use of hyaluronic acid in the treatment of tendinopathies. Methods: This review was constructed using the Medline database via Pubmed, Scopus and Google Scholar. The keywords hyaluronic acid, tendon and tendinopathy were used for the research. Results: In total, 27 articles (in English and French) on the application of hyaluronic acid to tendons were selected for their relevance and scientific quality, including eight for the 'in vitro' part, three for the 'in vivo' animal part and six for the human section. Conclusions: Preclinical studies demonstrate encouraging results: HA permits tendon gliding, reduces adhesions, creates better tendon architectural organisation and limits inflammation. These laboratory observations appear to be supported by limited but encouraging short-term clinical results on pain and function. However, controlled randomised studies are still needed. [less ▲]Detailed reference viewed: 40 (8 ULg) Platelet-rich plasma (PRP) to treat chronic patellar tendinopathies: comparison of a single versus two closely-timed injectionsKaux, Jean-François ; Libertiaux, Vincent ; Croisier, Jean-Louis et alin Muscles, Ligaments and Tendons Journal (2016), 5(4 (eCollection 2015 Oct-Dec)), 297-298Detailed reference viewed: 28 (2 ULg) Le médicament du mois. Insuline glargine 300 U/mL (Toujeo®)SCHEEN, André in Revue Médicale de Liège (2016), 71Summary : This article presents a new formulation of insulin glargine concentrated at 300 U/mL (Gla-300). It is commercialized under the trade name of Toujeo® in an optimized pre-filled SoloStar™ pen for ... [more ▼]Summary : This article presents a new formulation of insulin glargine concentrated at 300 U/mL (Gla-300). It is commercialized under the trade name of Toujeo® in an optimized pre-filled SoloStar™ pen for the treatment of type 1 and type 2 diabetes in adults. Besides a threefold higher concentration compared to the classical insulin Lantus® (100 U/mL or Gla-100), both pharmacokinetic and pharmacodynamic profiles of Gla-300 are flatter and longer (more than 24 hours) and have a lesser intra-/inter-variability, which makes them more reproducible. Overall, Toujeo® offers the same hypoglycaemic efficacy and the same safety profile when compared with Lantus®. However, a lower risk of hypoglycaemia, especially at night, a slightly smaller weight gain and a better flexibility in the time of injection have been reported. The two insulin formulations are not bioequivalent and the daily insulin requirement is slightly higher with insulin Gla-300 than with insulin Gla-100. The shift from an already available basal insulin towards Toujeo® may require a dose adjustment and a reinforcement of blood glucose monitoring. [less ▲]Detailed reference viewed: 94 (1 ULg) Mesh Management Methods in Finite Element Simulations of Orthodontic Tooth MovementMengoni, Marlène ; Ponthot, Jean-Philippe ; Boman, Romain in Medical Engineering & Physics (2016), 38(2), 140-147In finite element simulations of orthodontic tooth movement, one of the challenges is to represent long term tooth movement. Large deformation of the periodontal ligament and large tooth displacment due ... [more ▼]In finite element simulations of orthodontic tooth movement, one of the challenges is to represent long term tooth movement. Large deformation of the periodontal ligament and large tooth displacment due to bone remodelling lead to large distortions of the finite element mesh when a Lagrangian formalism is used. We propose in this work to use an Arbitrary Lagrangian Eulerian (ALE) formalism to delay remeshing operations. A large tooth displacement is obtained including effect of remodelling without the need of remeshing steps but keeping a good-quality mesh. Very large deformations in soft tissues such as the periodontal ligament is obtained using a combination of the ALE formalism used continuously and a remeshing algorithm used when needed. This work demonstrates that the ALE formalism is a very efficient way to delay remeshing operations. [less ▲]Detailed reference viewed: 75 (22 ULg) On the equivalent static load method for flexible multibody systems described with a nonlinear finite element formalismTromme, Emmanuel ; Sonneville, Valentin ; Bruls, Olivier et alin International Journal for Numerical Methods in Engineering (2016)The equivalent static load (ESL) method is a powerful approach to solve dynamic response structural optimization problems. The method transforms the dynamic response optimization into a static response ... [more ▼]The equivalent static load (ESL) method is a powerful approach to solve dynamic response structural optimization problems. The method transforms the dynamic response optimization into a static response optimization under multiple load cases. The ESL cases are defined based on the transient analysis response whereupon all the standard techniques of static response optimization can be used. In the last decade, the ESL method has been applied to perform the structural optimization of flexible components of mechanical systems modeled as multibody systems (MBS). The ESL evaluation strongly depends on the adopted formulation to describe the MBS and has been initially derived based on a floating frame of reference formulation. In this paper, we propose a method to derive the ESL adapted to a nonlinear finite element approach based on a Lie group formalism for two main reasons. Firstly, the finite element approach is completely general to analyze complex MBS and is suitable to perform more advanced optimization problems like topology optimization. Secondly, the selected Lie group formalism leads to a formulation of the equations of motion in the local frame, that turns out to be a strong practical advantage for the ESL evaluation. Examples are provided to validate the proposed method. [less ▲]Detailed reference viewed: 37 (3 ULg) Residual tumor micro-foci and overwhelming regulatory T lymphocyte infiltration are the causes of bladder cancer recurrence.Parodi, Alessia; Traverso, Paolo; Kalli, Francesca et alin Oncotarget (2016), 7(6), 6424-6435Bladder cancer has an unexplained, high recurrence rate. Causes of recurrence might include the presence of sporadic tumor micro-foci in the residual urothelial tissue after surgery associated with an ... [more ▼]Bladder cancer has an unexplained, high recurrence rate. Causes of recurrence might include the presence of sporadic tumor micro-foci in the residual urothelial tissue after surgery associated with an inverted ratio between intratumoral effector and regulatory T cell subsets. Hence, surgical specimens of both tumors and autologous, macroscopically/histologically free-of-tumor tissues were collected from 28 and 20 patients affected by bladder or renal cancer, respectively. The frequencies of effector (IFNγ+ and IL17+ T cells) and regulatory (CD4+CD25hiCD127lo and CD8+CD28-CD127loCD39+ Treg) T cell subpopulations among tumor infiltrating lymphocytes were analyzed by immunofluorescence, while the gene expression of MAGE-A1 and MAGE-A2 tumor-associated antigens was studied by RT-PCR. The results show that both the T cell infiltrate and the frequency of MAGE-A1/A2 gene expression were comparable in tumors and in autologous free-of-tumor tissues in bladder cancer, while the autologous free-of-tumor renal tissues showed reduced T cell infiltrate and frequency of MAGE gene expression as compared to the autologous tumors. Importantly, the intra-tumor T effector/Treg cell ratio was consistently <1 in bladder cancer patients (n. 7) who relapsed within two years, while it was always >1 in patients (n. 6) without recurrence (regardless of tumor stage) (P = 0.0006, Odds ratio = 195). These unprecedented findings clarify the pathogenic mechanism of bladder cancer recurrence and suggest that microscopically undetectable micro-foci of tumor may predispose to recurrence when associated with an inverted intratumoral T effector/Treg cell ratio. [less ▲]Detailed reference viewed: 94 (1 ULg) Simultaneous production of acetic and gluconic acids by a thermotolerant Acetobacter strain during acetous fermentation in a bioreactorMounir, Majid ; shafiei, rasoul; Zarmehrkhorshid, Raziyeh et alin Journal of Bioscience & Bioengineering (2016), 121(2), 166-171The activity of bacterial strains significantly influences the quality and the taste of vinegar. Previous studies of acetic acid bacteria have primarily focused on the ability of bacterial strains to ... [more ▼]The activity of bacterial strains significantly influences the quality and the taste of vinegar. Previous studies of acetic acid bacteria have primarily focused on the ability of bacterial strains to produce high amounts of acetic acid. However, few studies have examined the production of gluconic acid during acetous fermentation at high temperatures. The production of vinegar at high temperatures by two strains of acetic acid bacteria isolated from apple and cactus fruits, namely AF01 and CV01, respectively, was evaluated in this study. The simultaneous production of gluconic and acetic acids was also examined in this study. Biochemical and molecular identification based on a 16s rDNA sequence analysis confirmed that these strains can be classified as Acetobacter pasteurianus. To assess the ability of the isolated strains to grow and produce acetic acid and gluconic acid at high temperatures, a semi-continuous fermentation was performed in a 20-L bioreactor. The two strains abundantly grew at a high temperature (41°C). At the end of the fermentation, the AF01 and CV01 strains yielded acetic acid concentrations of 7.64% (w/v) and 10.08% (w/v), respectively. Interestingly, CV01 was able to simultaneously produce acetic and gluconic acids during acetic fermentation, whereas AF01 mainly produced acetic acid. In addition, CV01 was less sensitive to ethanol depletion during semi-continuous fermentation. Finally, the enzymatic study showed that the two strains exhibited high ADH and ALDH enzyme activity at 38°C compared with the mesophilic reference strain LMG 1632, which was significantly susceptible to thermal inactivation. [less ▲]Detailed reference viewed: 46 (8 ULg) The impact of dissolved organic carbon and bacterial respiration on pCO2 in experimental sea iceZhou, Jiayun; Kotovitch, Marie ; Kaartokallio, H. et alin Progress in Oceanography (2016), 141Previous observations have shown that the partial pressure of carbon dioxide (pCO2) in sea ice brines is generally higher in Arctic sea ice compared to those from the Antarctic sea ice, especially in ... [more ▼]Previous observations have shown that the partial pressure of carbon dioxide (pCO2) in sea ice brines is generally higher in Arctic sea ice compared to those from the Antarctic sea ice, especially in winter and early spring. We hypothesized that these differences result from the higher dissolved organic carbon (DOC) content in Arctic seawater: Higher concentrations of DOC in seawater would be reflected in a greater DOC incorporation into sea ice, enhancing bacterial respiration, which in turn would increase the pCO2 in the ice. To verify this hypothesis, we performed an experiment using two series of mesocosms: one was filled with seawater (SW) and the other one with seawater with an addition of filtered humic-rich river water (SWR). The addition of river water increased the DOC concentration of the water from a median of 142 µmol L-1 in SW to 249 µmol L-1 in SWR. Sea ice was grown in these mesocosms under the same physical conditions over 19 days. Microalgae and protists were absent, and only bacterial activity has been detected. We measured the DOC concentration, bacterial respiration, total alkalinity and pCO2 in sea ice and the underlying seawater, and we calculated the changes in dissolved inorganic carbon (DIC) in both media. We found that bacterial respiration in ice was higher in SWR: median bacterial respiration was 25 nmol C L-1 h-1 compared to 10 nmol C L-1 h-1 in SW. pCO2 in ice was also higher in SWR with a median of 430 ppm compared to 356 ppm in SW. However, the differences in pCO2 were larger within the ice interiors than at the surfaces or the bottom layers of the ice, where exchanges at the air-ice and ice-water interfaces might have reduced the differences. In addition, we used a model to simulate the differences of pCO2 and DIC based on bacterial respiration. The model simulations support the experimental findings and further suggest that bacterial growth efficiency in the ice might be 0.15-0.2. It is thus credible that the higher pCO2 in Arctic sea ice brines compared with those from the Antarctic sea ice were due to an elevated bacterial respiration, sustained by higher riverine DOC loads. These conclusions should hold for locations and time frames when bacterial activity is relatively dominant compared to algal activity, considering our experimental conditions. [less ▲]Detailed reference viewed: 47 (5 ULg) A 3-year long study of Staphylococcus aureus isolates from subclinical mastitis in three Azawak zebu herds at the Sahelian experimental farm of Toukounous, NigerIssa Ibrahim, Abdoulkarim; Duprez, Jean-Noël ; Bada-alambdeji, Rianatou et alin Tropical Animal Health and Production (2016), 48(2), 321-329bovine mastitis. The aim of the present work was to follow in three herds and during the 3 years the clonality of S. aureus isolated from California Mastitis Test (CMT)-positive cows at the experimental ... [more ▼]bovine mastitis. The aim of the present work was to follow in three herds and during the 3 years the clonality of S. aureus isolated from California Mastitis Test (CMT)-positive cows at the experimental station of Toukounous (Niger) by (i) comparing their pulsed field gel electrophoresis (PFGE) fingerprints, (ii) identifying their virulotypes by PCR amplification and (iii) assessing the production of capsule and the formation of biofilm. The 88 S. aureus isolates belonged to 14 different pulsotypes, 3 of them being predominant: A (30 %), D (27 %), B (15 %). A and B pulsotypes had the highest profile similarity coefficient (94 %), while others had similarity coefficients under 60 %. Seventy-five S. aureus isolates were further studied for their virulotypes, capsular antigens and biofilm production. Most surface factor-, leukocidin- and haemolysin-, but not the enterotoxin-encoding genes were detected in the majority (>75 %) of the isolates and were evenly distributed between the A, B and D pulsotype isolates. The majority of the 72 S. aureus positive with the cap5H or cap8H PCR produced the CP5 (82 %) or the CP8 (88 %) capsular antigen, respectively. Biofilm production by the 57 icaA-positive isolates was strong for 8 isolates, moderate for 31 isolates but weak for 18 isolates, implying that the icaA gene may not be expressed in vitro by one third of the positive isolates. Similar to other studies, those results confirm that a restricted number of S. aureus clones circulate within the three herds at Toukounous and that their specific virulence-associated properties must still be further studied [less ▲]Detailed reference viewed: 30 (10 ULg) Let’s work togetherChatelus, Renaud ; Sevini, Filippoin WorldECR (2016), issue 47Export control systems are complex by nature. They involve many national stakeholders. A typical national export controlapparatus requires the cooperation of between seven and 15 governmental ministries ... [more ▼]Export control systems are complex by nature. They involve many national stakeholders. A typical national export controlapparatus requires the cooperation of between seven and 15 governmental ministries, services and agencies, each having its own mandate, constraints and work culture. But export control cannot be seen from a purely national perspective. Export control’s ultimate purpose, overall efficacy, and legal basis are genuinely international. International instruments and bodies, such as Resolution 1540 and its committee, or the various multilateral export control regimes, provide some guidance and opportunities for cooperation. It is, however, far from sufficient for addressing all the cooperation challenges at the national and international levels. Recognising this important need for cooperation, the Nuclear Security Unit of the European Joint Research Centre in Ispra, Italy, organised in March 2015, a three-day innovative EU export control simulation exercise with operatives of 11 Member States, involving standard work processes as well as specific fraud patterns. [less ▲]Detailed reference viewed: 16 (1 ULg) SHANNA WATERSTOWN La tornade noire venue de FlorideSacré, Robert in ABS Magazine (2016), (49), Interview de la chanteuse noire américaine Shanna Waterstown ; son histoire et son parcours artistiqueDetailed reference viewed: 17 (1 ULg) Growth partitioning within beech trees (Fagus sylvatica L.) varies in response to summer heat waves and related droughtsLatte, Nicolas ; Lebourgeois, François; Claessens, Hugues in Trees (2016), 30(1), 189-201To characterize growth partitioning within the tree and its responses to climate, we studied 8 dominant beech trees (Fagus sylvatica L.) of a pure, even-aged 98-year-old stand in Belgium. We sampled 10 ... [more ▼]To characterize growth partitioning within the tree and its responses to climate, we studied 8 dominant beech trees (Fagus sylvatica L.) of a pure, even-aged 98-year-old stand in Belgium. We sampled 10 disks along the stem from breast height to treetop and examined the inter-annual patterns of, and discrepancies between, ring-area and volume increments by performing detailed stem analysis and dendroecological investigations. Although the common inter-annual variation among all increment series was high, we observed increasing growth variability and climate sensitivity with height, leading to notable bole-crown discrepancies. Both the common inter-annual variation and bole-crown discrepancies were mainly driven by summer heat waves and related droughts of the previous year, and spring droughts of the current year. Despite these discrepancies, the radial growth at breast height can be considered a good estimate of the tree volume increment but not for the purpose of focusing on climatic effects of isolated years. Extreme climatic conditions increase the risk of inaccurate estimations. The results of the present study are discussed in relation to tree ecophysiology hypotheses. [less ▲]Detailed reference viewed: 58 (17 ULg) Numerical modeling of the long term behavior of Municipal Solid Waste in a bioreactor landfillHubert, Julien ; Xianfeng, Liu; Collin, Frédéric in Computers and Geotechnics (2016), 72This paper presents a thermo-hydro–biochemo-mechanical model for simulating the long term behavior of Municipal Solid Waste (MSW) in a bioreactor landfill, in which the multi-physics coupling mechanism ... [more ▼]This paper presents a thermo-hydro–biochemo-mechanical model for simulating the long term behavior of Municipal Solid Waste (MSW) in a bioreactor landfill, in which the multi-physics coupling mechanism plays a dominant role. In the model, a two-stage anaerobic biochemical model based on McDougall’s formulation is incorporated into a fully coupled thermo-hydro-mechanical models originally developed for unsaturated porous medium. The mechanical model is a modified Camclay model allowing for biochemical hardening/softening, while the thermal model is described by a classical energy balance equation with a source term accounting for the heat generation from the biodegradation of organic matter. The hydraulic model is an unsaturated flow model using Richard’s equation. The derived coupled model is implemented into an in-house built multi-physics finite element code. Finally, numerical simulations were performed to illustrate the capability of the proposed model for estimating long-term settlement of a bioreactor landfill and its aptitude as a landfill management tool for optimizing the landfill operation [less ▲]Detailed reference viewed: 49 (9 ULg) Reverse genetic screen for loss-of-function mutations uncovers a frame-shifting deletion in the melanophilin gene accountable for a distinctive coat-color in Belgian Blue Cattle.Li, Wanbo; Sartelet, Arnaud ; Tamma, Nico et alin Animal Genetics (2016), 47(1), 110-113Detailed reference viewed: 48 (7 ULg) Gallium-68-labelled NOTA-oligonucleotides: An optimized method for their preparationGijs, Marlies; Dammicco, Sylvestre ; Warnier, Corentin et alin Journal of Labelled Compounds & Radiopharmaceuticals (2016)One of the most essential aspects to the success of radiopharmaceuticals is an easy and reliable radiolabelling protocol to obtain pure and stable products. In this study, we optimized the bioconjugation ... [more ▼]One of the most essential aspects to the success of radiopharmaceuticals is an easy and reliable radiolabelling protocol to obtain pure and stable products. In this study, we optimized the bioconjugation and gallium-68 ((68) Ga) radiolabelling conditions for a single-stranded 40-mer DNA oligonucleotide, in order to obtain highly pure and stable radiolabelled oligonucleotides. Quantitative bioconjugation was obtained for a disulfide-functionalized oligonucleotide conjugated to the macrocylic bifunctional chelator MMA-NOTA (maleimido-mono-amide (1,4,7-triazanonane-1,4,7-triyl)triacetic acid). Next, this NOTA-oligonucleotide bioconjugate was radiolabelled at room temperature with purified and pre-concentrated (68) Ga with quantitative levels of radioactive incorporation and high radiochemical and chemical purity. In addition, high chelate stability was observed in physiological-like conditions (37 °C, PBS and serum), in the presence of a transchelator (EDTA) and transferrin. A specific activity of 51.1 MBq/nmol was reached using a 1470-fold molar excess bioconjugate over (68) Ga. This study presents a fast, straightforward and reliable protocol for the preparation of (68) Ga-radiolabelled DNA oligonucleotides under mild reaction conditions and without the use of organic solvents. The methodology herein developed will be applied to the preparation of oligonucleotidic sequences (aptamers) targeting the human epidermal growth factor receptor 2 (HER2) for cancer imaging. [less ▲]Detailed reference viewed: 16 (3 ULg) Master equation for collective spontaneous emission with quantized atomic motionDamanet, François ; Braun, Daniel; Martin, John in Physical Review A (2016), 93We derive a Markovian master equation for the internal dynamics of an ensemble of two-level atoms including all effects related to the quantization of their motion. Our equation provides a unifying ... [more ▼]We derive a Markovian master equation for the internal dynamics of an ensemble of two-level atoms including all effects related to the quantization of their motion. Our equation provides a unifying picture of the consequences of recoil and indistinguishability of atoms beyond the Lamb-Dicke regime on both their dissipative and conservative dynamics, and applies equally well to distinguishable and indistinguishable atoms. We give general expressions for the decay rates and the dipole-dipole shifts for any motional states, and we find closed-form formulas for a number of relevant states (Gaussian states, Fock states, and thermal states). In particular, we show that dipole-dipole interactions and cooperative photon emission can be modulated through the external state of motion. [less ▲]Detailed reference viewed: 20 (8 ULg) Circling and touching: two new behaviours in the courtship of the Picasso triggerfish Rhinecanthus aculeatus (Linnaeus, 1758)Raick, Xavier ; Parmentier, Eric ; Lecchini, Davidin Marine Biodiversity (2016)Detailed reference viewed: 16 (1 ULg) Traitement chirurgical d'une persistance du canal artériel chez un chaton de 4 semainesHage, Christelle ; Merveille, Anne-Christine ; Claeys, Stéphanie in Monde Vétérinaire (Le) (2016), 157Detailed reference viewed: 20 (2 ULg) Prospects of a new dynamic simulation software for real-time applications on the Hydro-Québec systemAristidou, Petros; Lebeau, Simon; Loud, Lester et alin CIGRE Science and Engineering (2016), 4Hydro-Québec has a long interest in on-line Dynamic Security Assessment (DSA) driven by its challenging system dynamics. Presently, off-line calculated security limits are combined with an on-line ... [more ▼]Hydro-Québec has a long interest in on-line Dynamic Security Assessment (DSA) driven by its challenging system dynamics. Presently, off-line calculated security limits are combined with an on-line monitoring system. However, new developments in dynamic simulation enable real-time or near-real-time DSA calculations and transfer limits determination. In this paper, the domain-decomposition-based algorithm implemented in the simulator RAMSES is presented, along with techniques to accelerate its sequential and parallel executions. RAMSES exploits the localized response to disturbances and the timescale decomposition of dynamic phenomena to provide sequential acceleration when the simulation is performed on a single processing unit. Additionally, when more units are available, the parallelization potential of domain-decomposition methods is exploited for further acceleration. The algorithm and techniques have been tested on a realistic model of the Hydro-Québec system to evaluate the accuracy of dynamic responses and the sequential and parallel performances. Finally, the real-time capabilities have been assessed using a shared-memory parallel processing platform. [less ▲]Detailed reference viewed: 36 (3 ULg) Analysis of the Structure and Function of FOX-4 CephamycinaseLefurgy, S.T.; Malashkevich, V.N.; Aguilan, J.T. et alin Antimicrobial Agents and Chemotherapy (2016), 60(2), 717-728Class C β-lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC β-lactamases conferring resistance to cefoxitin ... [more ▼]Class C β-lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC β-lactamases conferring resistance to cefoxitin, the FOX family, has grown to include nine unique members descended from the Aeromonas caviae chromosomal AmpC. To understand the basis for the unique cephamycinase activity in the FOX family, we determined the first X-ray crystal structures of FOX-4, apo enzyme and the acyl-enzyme with its namesake compound, cefoxitin, using the Y150F deacylation-deficient variant. Notably, recombinant expression of N-terminally tagged FOX-4 also yielded an inactive adenylylated enzyme form not previously observed in β-lactamases. The posttranslational modification (PTM), which occurs on the active site Ser64, would not seem to provide a selective advantage, yet might present an opportunity for the design of novel antibacterial drugs. Substantial ligand-induced changes in the enzyme are seen in the acyl-enzyme complex, particularly the R2 loop and helix H10 (P289 to N297), with movement of F293 by 10.3 Å. Taken together, this study provides the first picture of this highly proficient class C cephamycinase, uncovers a novel PTM, and suggests a possible cephamycin resistance mechanism involving repositioning of the substrate due to the presence of S153P, N289P, and N346I substitutions in the ligand binding pocket. [less ▲]Detailed reference viewed: 14 (3 ULg) Concordance between Iothalamate and Iohexol Plasma ClearanceDELANAYE, Pierre ; LE GOFF, Caroline ; JOURET, François et alin American Journal of Kidney Diseases (2016), 68(2), 329-330Detailed reference viewed: 16 (4 ULg) Use of dual carbon-chlorine isotope analysis to assess the degradation pathways of 1,1,1-trichloroethane in groundwaterPalau, Jordi; Jamin, Pierre ; Badin, Alice et alin Water Research (2016)Compound-specific isotope analysis (CSIA) is a powerful tool to track contaminant fate in groundwater. However, the application of CSIA to chlorinated ethanes has received little attention so far. These ... [more ▼]Compound-specific isotope analysis (CSIA) is a powerful tool to track contaminant fate in groundwater. However, the application of CSIA to chlorinated ethanes has received little attention so far. These compounds are toxic and prevalent groundwater contaminants of environmental concern. The high susceptibility of chlorinated ethanes like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the assessment of their fate in the subsurface. In this study, the use of a dual C-Cl isotope approach to identify the active degradation pathways of 1,1,1-TCA is evaluated for the first time in an aerobic aquifer impacted by 1,1,1-TCA and trichloroethylene (TCE) with concentrations of up to 20 mg/L and 3.4 mg/L, respectively. The reaction-specific dual carbon-chlorine (C-Cl) isotope trends determined in a recent laboratory study illustrated the potential of a dual isotope approach to identify contaminant degradation pathways of 1,1,1-TCA. Compared to the dual isotope slopes (Δδ13C/Δδ37Cl) previously determined in the laboratory for dehydrohalogenation / hydrolysis (DH/HY, 0.33 ± 0.04) and oxidation by persulfate (∞), the slope determined from field samples (0.6 ± 0.2, r2 = 0.75) is closer to the one observed for DH/HY, pointing to DH/HY as the predominant degradation pathway of 1,1,1-TCA in the aquifer. The observed deviation could be explained by a minor contribution of additional degradation processes. This result, along with the little degradation of TCE determined from isotope measurements, confirmed that 1,1,1-TCA is the main source of the 1,1-dichlorethylene (1,1-DCE) detected in the aquifer with concentrations of up to 10 mg/L. This study demonstrates that a dual C-Cl isotope approach can strongly improve the qualitative and quantitative assessment of 1,1,1-TCA degradation processes in the field. [less ▲]Detailed reference viewed: 50 (7 ULg) Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)Cooper, C.; Bardin, T.; Brandi, M.L. et alin Aging Clinical and Experimental Research (2016), 28(1), 1-16Purpose: This consensus review article considers the question of whether glucocorticoid (GC) therapy is still relevant in the treatment of rheumatic diseases, with a particular focus on rheumatoid ... [more ▼]Purpose: This consensus review article considers the question of whether glucocorticoid (GC) therapy is still relevant in the treatment of rheumatic diseases, with a particular focus on rheumatoid arthritis (RA), and whether its side effects can be adequately managed. Recent basic and clinical research on the molecular, cellular and clinical effects of GCs have considerably advanced our knowledge in this field. An overview of the subject seems appropriate. Methods: This review is the result of a multidisciplinary expert working group, organised by European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. The recent literature was surveyed and the salient evidence synthetized. Results: The pathophysiological basis of RA (and other inflammatory rheumatic diseases) now strongly implicates the adaptive immune system in addition to innate mechanisms. The molecular effect of GCs and differential GC sensitivity is better understood, although exploiting this knowledge is still in its infancy. The newer treatment strategies of early and aggressive control of RA have greatly improved clinical outcomes, but improvements are still possible. Newer targeted anti-inflammatory drugs have made an important impact, yet they too are associated with numerous side effects. Discussion: Short durations of moderate doses of GCs are generally well tolerated and have a positive benefit/risk ratio. Patients should be assessed for fracture risk and bone preserving agents and be prescribed calcium and vitamin D supplementation. Conclusions: Within a strategy of a disease modifying approach to inflammatory disease, combination therapy including a GC is effective approach. [less ▲]Detailed reference viewed: 10 (4 ULg) Does biobased polymer achieve better environmental impacts than fossil polymer? Comparison of fossil HDPE and biobased HDPE produced from sugar beet and wheatBelboom, Sandra ; Léonard, Angélique in Biomass & Bioenergy (2016), 85Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed ... [more ▼]Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed, the transformation of biobased ethanol into biobased polymer being one of them. This paper undertakes an environmental evaluation of the production of biobased polymer produced from two different feedstock cultivated in Belgium: sugar beet and wheat. Both crops cultivation are studied as well as their transformation into biobased ethanol, first, and then to biobased ethylene, focusing on high-density polyethylene (HDPE) as final product. These scenarios are analyzed and compared with the production of conventional polymer using the life-cycle assessment (LCA) methodology with reference to relevant environmental impact categories. This study shows a reduction of impact of around 60% for both climate change and fossil fuel depletion categories when using biobased HDPE instead of its fossil counterpart. For all other impact categories, fossil HDPE achieves better results than the biobased product. [less ▲]Detailed reference viewed: 58 (7 ULg) The new Sfar journals are in placePlaud, B; Lefrant, JY; BRICHANT, Jean-François in Current Anaesthesia and Critical Care (2016)Detailed reference viewed: 5 (1 ULg) Le livre au futur antérieur. Les ambiguïtés d’un motif d’anticipationStienon, Valérie ; Barel-Moisan, Clairein Autour de Vallès : Revue de Lectures et d'Etudes Vallésiennes (2016), 45(2015), 147-168Du tournant du XIXe siècle aux années 1940, le récit d’anticipation est enclin à articuler un imaginaire social et des extrapolations du présent qui le portent à considérer, parmi d’autres aspects ... [more ▼]Du tournant du XIXe siècle aux années 1940, le récit d’anticipation est enclin à articuler un imaginaire social et des extrapolations du présent qui le portent à considérer, parmi d’autres aspects socioculturels, la situation de la littérature et de ce qu’on peut nommer le modèle culturel « lettré », avec son histoire, ses valeurs, ses acteurs et ses institutions. Sur ce point, on peut observer à la fois la perméabilité des fictions conjecturales aux discours et représentations liés à leur premier contexte, et les modulations originales qu’elles y apportent. [less ▲]Detailed reference viewed: 23 (3 ULg) Doing better in more complex patients: leading the way for QUIP.Osnabrugge, Ruben L.; Kappetein, A. Pieter; Head, Stuart J. et alin European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(2), 397-8Detailed reference viewed: 24 (5 ULg) Substituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activitiesMarquise, Nada; Chevallier, Floris; Nassar, Ekhlas et alin Tetrahedron (2016), 72(6), 825-836Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions ... [more ▼]Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties [less ▲]Detailed reference viewed: 28 (13 ULg) Coeur de crècheCourtejoie, Fabienne in A+ Architecture en Belgique (2016), 258Detailed reference viewed: 27 (4 ULg) Conséquences génétiques et morphologiques des glaciations du Quaternaire : une lignée relique du barbeau (Luciobarbus pallaryi, Cyprinidae) dans le bassin du Guir (Algerie)Brahimi, Amina; Tarai, Nacer; Benhassane, Abdelkrim et alin Comptes Rendus Biologies (2016), 339Climatic variations during the Quaternary period had a considerable impact on landscapes and habitat fragmentation (rivers) in North Africa. These historical events can have significant consequences on ... [more ▼]Climatic variations during the Quaternary period had a considerable impact on landscapes and habitat fragmentation (rivers) in North Africa. These historical events can have significant consequences on the genetic structure of the populations. Indeed, geographi- cally separated and genetically isolated populations tend to differentiate themselves through time, eventually becoming distinct lineages, allowing new species to emerge in later generations. The aim of the present study is to use genetic and morphological techniques to evaluate the major role of the Saalian glaciation (Middle Quaternary) in the establishment of the geographic space and in the evolution of the intraspecific genetic diversity, by tracing the demographic history of barbels belonging to the Luciobarbus pallaryi (Cyprinidae) species in the Guir Basin (Algeria). In this context, two populations, from two distinct and isolated sites, were studied. Analysis of the cytochrome b (cyt b) mitochondrial markers and of the ‘‘D-loop’’ control region has shown that the ‘‘upstream’’ and ‘‘downstream’’ Guir populations are genetically differentiated. The molecular analyses suggest that the upstream population was disconnected from this hydrographic system during the Saalian glaciation period of the Quaternary. Subsequently, it was isolated in the foggaras underground waters in the Great Western Erg, at approximately 320 000 years BP, creating, through a bottleneck effect, a new allopatric lineage referred to as ‘‘Adrar’’. Conversely, the high genetic diversity in the upstream Guir (Bechar) population suggests that the stock is globally in expansion. These barbels (n = 52) were also examined with meristic, morphometric, osteological, and biological features [less ▲]Detailed reference viewed: 36 (12 ULg) TEST-RETEST RELIABILITY OF TWO CLINICAL TESTS FOR THE ASSESSMENT OF HIP ABDUCTOR ENDURANCE IN HEALTHY FEMALESVan Cant, Joachim; Dumont, Gregory; Pitance, Laurent et alin The International Journal of Sports Physical Therapy (2016), 11(1), 24-33Detailed reference viewed: 20 (0 ULg) Is Darwin's 'Abominable Mystery' still a mystery today?Cascales-Miñana, Borja ; Cleal, Chris J.; Gerrienne, Philippe in Cretaceous Research (2016), 61Detailed reference viewed: 39 (6 ULg) Walphy, un projet expérimental de réhabilitation de cours d’eau : suivis hydromorphologiques et écologiquesCastelain, Liévin; Peeters, Alexandre ; Halleux, Marie et alin Hydroécologie Appliquée (2016)Le projet Life Environnement WALPHY, co-financé par l’Union Européenne, a eu pour objectif de réaliser des travaux de restauration de la qualité hydromorphologique du Bocq, affluent de la Meuse. La ... [more ▼]Le projet Life Environnement WALPHY, co-financé par l’Union Européenne, a eu pour objectif de réaliser des travaux de restauration de la qualité hydromorphologique du Bocq, affluent de la Meuse. La continuité longitudinale, qui concerne la libre circulation des poissons et le transport naturel des sédiments, a été fortement perturbée par un grand nombre d’obstacles (vannages, déversoirs, …). Afin de rétablir cette continuité, des travaux d’arasement ou d’aménagement (passes à bassins, bras de contournement, rampes rugueuses...) d’obstacles ont été réalisés. De plus, des travaux de reméandration, de diversification des écoulements ou de création d’habitats piscicoles ont été menés afin d’améliorer la continuité transversale. Ces travaux ont fait l’objet de suivis scientifiques sur base d’analyses géomorphologiques, hydromorphologiques et écologiques. Des méthodes standardisées et reproductibles ont été mises au point pour comparer la situation avant et après travaux. L’application de ces méthodes a montré que le suivi des microhabitats couplé à l’analyse des populations de macroinvertébrés et de poissons est à même de mettre en évidence les évolutions post-travaux. Deux exemples d’études avant et après travaux sont présentés : l’arasement d’un déversoir et la reméandration d’un secteur rectifié. Les résultats montrent une bonne évolution des indicateurs biologiques. [less ▲]Detailed reference viewed: 21 (1 ULg) Data-driven selection of the minimum-gradient support parameter in time-lapse focused electrical imagingNguyen, Frédéric ; Kemna, Andreas; Robert, Tanguy et alin Geophysics (2016), 81(1), 1-5We have considered the problem of the choice of the minimum-gradient support (MGS) parameter in focused inversion for time-lapse (TL) electric resistivity tomography. Most existing approaches have relied ... [more ▼]We have considered the problem of the choice of the minimum-gradient support (MGS) parameter in focused inversion for time-lapse (TL) electric resistivity tomography. Most existing approaches have relied either on an arbitrary choice of this parameter or one based on the prior information, such as the expected contrast in the TL image. We have decided to select the MGS parameter using a line search based on the value of the TL data root-mean-square misfit at the first iteration of the nonlinear inversion procedure. The latter was based on a Gauss-Newton scheme minimizing a regularized objective function in which the regularization functional was defined by the MGS functional. The regularization parameter was optimized to achieve a certain target level, following the Occam principles. We have validated our approach on a synthetic benchmark using a complex and heterogeneous model and determined its effectiveness on electric tomography TL data collected during a salt tracer experiment in fractured limestone. Our results have determined that the approach was successful in retrieving the focused anomaly and did not rely on prior information. [less ▲]Detailed reference viewed: 94 (20 ULg) Experimental comparison of organic fluids for low temperature ORC (organic Rankine cycle) systems for waste heat recovery applicationsDesideri, Adriano ; Gusev, Sergei; Van den Broek, Martijn et alin Energy (2016), 97This contribution experimentally evaluates and compares the performance of an ORC (organic Rankine cycle) system for stationary bottoming WHR (waste heat recovery) application operating with two different ... [more ▼]This contribution experimentally evaluates and compares the performance of an ORC (organic Rankine cycle) system for stationary bottoming WHR (waste heat recovery) application operating with two different working fluids, SES36 and R245fa. The test rig is a regenerative cycle equipped with a single screw expander modified from a standard compressor characterized by a nominal shaft power of 11 kW. A total of 36 and 43 steady-state points are collected for SES36 and R245fa respectively, over a wide range of operating conditions by changing the expander rotational speed, the pump frequency and the cooling condenser flow rate. The performances of the ORC components are individually evaluated. A maximum expander isentropic efficiency of 60% is reached using SES36 at 3000 rpm, and a value of 52% is reached with R245fa at 3000 rpm. However, for a given pressure ratio the expander output power is higher with R245fa than with SES36. The overall performance of the ORC unit are investigated in terms of first and second law efficiencies and net output power for the two fluids. The results experimentally demonstrate the correlation between the working fluid critical temperature and the ORC unit working characteristics for low temperature waste heat recovery applications. Open experimental data are provided for both fluids. [less ▲]Detailed reference viewed: 27 (4 ULg) Identités, préférences et attitudes des parlementaires envers le fédéralisme belge après la sixième réforme de l’ÉtatDodeigne, Jérémy ; Reuchamps, Min; Sinardet, Davein Courrier Hebdomadaire du CRISP (2016), 33Detailed reference viewed: 19 (9 ULg) A comparative study of models for shear strength of reinforced concrete deep beamsLiu, Jian ; Mihaylov, Boyan in Engineering Structures (2016), 112(April), 81-89Since the 1960s, researchers have proposed different empirical formulas and analytical models for the shear strength of deep reinforced concrete beams. Some of these approaches have shown adequate ... [more ▼]Since the 1960s, researchers have proposed different empirical formulas and analytical models for the shear strength of deep reinforced concrete beams. Some of these approaches have shown adequate accuracy when applied to small sets of beam tests, while their ability to predict the effect of a large range of test variables remains unknown. This paper presents a summary of models for deep beams from 73 publications, and focuses on a detailed evaluation of ten more recent models by using a database of 574 deep beam tests. It is found that a semi-empirical strut-and-tie model (STM) and a two-parameter kinematic theory (2PKT) for deep beams produce the least scattered predictions. The former model produced an average shear strength experimental-to-predicted ratio Vexp/Vpred of 1.00 with a coefficient of variation (COV) of 19.8%, while the latter resulted in an average of 1.08 with a COV of 15.4%. The two models are also compared by plotting the Vexp/Vpred ratios against different tests variables, and by performing parametric studies with individual test series. It is shown that the semi-empirical STM exhibits certain bias with respect to the shear-span-to-depth ratio, while the 2PKT produces uniform results across the entire range of experimental data. It is also noted that the semi-empirical STM requires somewhat less computational effort than the 2PKT approach. [less ▲]Detailed reference viewed: 32 (18 ULg) Compte-rendu de l'ouvrage de S. Gatto : Blues delle zuccheCurreri, Luciano in La poesia e lo spirito (2016)Detailed reference viewed: 25 (4 ULg) Study of the effect of amino-functionalized multiwall carbon nanotubes on dry sliding wear resistance properties of carbon fiber reinforced thermoset polymersPincheira, G.; Montalba, C.; Gacitua, W. et alin Polymer Bulletin (2016)This work investigates the effect of multiwall carbon nanotubes (MWCNTs) on the mechanical and tribological behavior of a fiber reinforced composite (FRC). Fiber reinforced composites and nano-engineered ... [more ▼]This work investigates the effect of multiwall carbon nanotubes (MWCNTs) on the mechanical and tribological behavior of a fiber reinforced composite (FRC). Fiber reinforced composites and nano-engineered FRCs are manufactured by resin transfer molding. In-plane tensile tests, in-plane shear tests and through-thickness compression tests are used to assess the influence of MWCNTs on the material mechanical behavior. Pin on disk dry sliding tests are used to quantify the effect of MWCNTs on the friction coefficient and the specific wear rate. It was determined that (1) MWCNTs have an influence on the improvement on both the through-thickness compression strength and the specific wear rate, and (2) they do not influence the material stiffness, in-plane tensile and shear strengths and the friction coefficient. It is assumed that the observed improvements are due to the demonstrated positive influence of the MWCNTs effect on the matrix/reinforcement interfacial strength and on the matrix fracture toughness. [less ▲]Detailed reference viewed: 49 (7 ULg) Quality Characteristics and Antioxidant Properties of Muffins Enriched with Date Fruit (Phoenix Dactylifera L.) Fiber ConcentratesMrabet, Abdessalem ; Rodríguez-Gutiérrez, Guillermo; Rodríguez-Arcos, Rocío et alin Journal of Food Quality (2016), 39(1), Secondary varieties of date from Tunisia are underutilized due to their low commercial quality. Fiber concentrates (DFC) can be obtained from these fruits after a steam pretreatment. DFCs were evaluated ... [more ▼]Secondary varieties of date from Tunisia are underutilized due to their low commercial quality. Fiber concentrates (DFC) can be obtained from these fruits after a steam pretreatment. DFCs were evaluated as a source of antioxidant dietary fiber for bakery products. Muffins were prepared with 2.5 and 5% flour substitution with DFCs obtained by treatments at 165 and 180C. The DFC-doughs presented a similar yield to the control but the muffins reached a lower volume. The density increase did not imply an increase in texture. In fact, the muffins with DFC-165 were the softest tested, although they had lower cohesiveness and springiness. The proximate composition was similar among samples. The DFCmuffins had higher antioxidant capacity than the control, and obtained good scores in the sensory evaluation. DFC-165 is a valuable ingredient for baked goods, but its effect on fat rancidity and staling delays should be confirmed. [less ▲]Detailed reference viewed: 24 (0 ULg) Soil-speciﬁc calibration of capacitance sensors considering clay content and bulk densityParvin, Nargish ; Degré, Aurore in Australian Journal of Soil Research (2016)Detailed reference viewed: 41 (29 ULg) Tradeoffs between Maize Silage Yield and Nitrate Leaching in a Mediterranean Nitrate- Vulnerable Zone under Current and Projected Climate ScenariosBasso, Bruno; Giola, Pietro; Dumont, Benjamin et alin PLoS ONE (2016), 11(1): e0146360Future climatic changes may have profound impacts on cropping systems and affect the agronomic and environmental sustainability of current N management practices. The objectives of this work were to i ... [more ▼]Future climatic changes may have profound impacts on cropping systems and affect the agronomic and environmental sustainability of current N management practices. The objectives of this work were to i) evaluate the ability of the SALUS crop model to reproduce experimental crop yield and soil nitrate dynamics results under different N fertilizer treatments in a farmer’s field, ii) use the SALUS model to estimate the impacts of different N fertilizer treatments on NO3- leaching under future climate scenarios generated by twenty nine different global circulation models, and iii) identify the management system that best minimizes NO3- leaching and maximizes yield under projected future climate conditions. A field experiment (maize-triticale rotation) was conducted in a nitrate vulnerable zone on the west coast of Sardinia, Italy to evaluate N management strategies that include urea fertilization (NMIN), conventional fertilization with dairy slurry and urea (CONV), and no fertilization (N0). An ensemble of 29 global circulation models (GCM) was used to simulate different climate scenarios for two Representative Circulation Pathways (RCP6.0 and RCP8.5) and evaluate potential nitrate leaching and biomass production in this region over the next 50 years. Data collected from two growing seasons showed that the SALUS model adequately simulated both nitrate leaching and crop yield, with a relative error that ranged between 0.4% and 13%. Nitrate losses under RCP8.5 were lower than under RCP6.0 only for NMIN. Accordingly, levels of plant N uptake, N use efficiency and biomass production were higher under RCP8.5 than RCP6.0. Simulations under both RCP scenarios indicated that the NMIN treatment demonstrated both the highest biomass production and NO3- losses. The newly proposed best management practice (BMP), developed from crop N uptake data, was identified as the optimal N fertilizer management practice since it minimized NO3- leaching and maximized biomass production over the long term. [less ▲]Detailed reference viewed: 69 (2 ULg) Group-theoretic restrictions on generation of CP-violation in multi-Higgs-doublet modelsBranco, Gustavo; Ivanov, Igor in Journal of High Energy Physics [=JHEP] (2016), 2016It has been known since decades that imposing a symmetry group G on the scalar sector of multi-Higgs-doublet models has consequences for CP -violation. In all examples of two- and three-Higgs-doublet ... [more ▼]It has been known since decades that imposing a symmetry group G on the scalar sector of multi-Higgs-doublet models has consequences for CP -violation. In all examples of two- and three-Higgs-doublet models equipped with symmetries, one observes the following intriguing property: if G prevents explicit CP -violation (CPV), at least in the neutral Higgs sector, then it also prevents spontaneous CPV, and if G allows explicit CPV, then it allows for spontaneous CPV. One is led to conjecture that this is a general phenomenon. In this paper, we prove this conjecture for any rephasing symmetry group G and any number of doublets. [less ▲]Detailed reference viewed: 6 (1 ULg) La médecine dans l’œil du cycloneCOUCKE, Philippe in Le spécialiste (2016)Detailed reference viewed: 41 (5 ULg) Feasibility of improving a priori regional climate model estimates of Greenland ice sheet surface mass loss through assimilation of measured ice surface temperaturesNavari, M.; Margulis, S.A.; Bateni, S.M. et alin Cryosphere (The) (2016), 10The Greenland ice sheet (GrIS) has been the focus of climate studies due to its considerable impact on sea level rise. Accurate estimates of surface mass fluxes would contribute to understanding the cause ... [more ▼]The Greenland ice sheet (GrIS) has been the focus of climate studies due to its considerable impact on sea level rise. Accurate estimates of surface mass fluxes would contribute to understanding the cause of its recent changes and would help to better estimate the past, current and future contribution of the GrIS to sea level rise. Though the estimates of the GrIS surface mass fluxes have improved significantly over the last decade, there is still considerable disparity between the results from different methodologies (e.g., Rae et al., 2012; Vernon et al., 2013). The data assimilation approach can merge information from different methodologies in a consistent way to improve the GrIS surface mass fluxes. In this study, an ensemble batch smoother data assimilation approach was developed to assess the feasibility of generating a reanalysis estimate of the GrIS surface mass fluxes via integrating remotely sensed ice surface temperature measurements with a regional climate model (a priori) estimate. The performance of the proposed methodology for generating an improved posterior estimate was investigated within an observing system simulation experiment (OSSE) framework using synthetically generated ice surface temperature measurements. The results showed that assimilation of ice surface temperature time series were able to overcome uncertainties in near-surface meteorological forcing variables that drive the GrIS surface processes. Our findings show that the proposed methodology is able to generate posterior reanalysis estimates of the surface mass fluxes that are in good agreement with the synthetic true estimates. The results also showed that the proposed data assimilation framework improves the root-mean-square error of the posterior estimates of runoff, sublimation/evaporation, surface condensation, and surface mass loss fluxes by 61, 64, 76, and 62 %, respectively, over the nominal a priori climate model estimates. [less ▲]Detailed reference viewed: 65 (1 ULg) Assessment of thermal comfort in existing pre-1945 residential building stockSingh, M.K.; Attia, Shady ; Mahapatra, Sadha et alin Energy (2016), 98(March), 122-134The building sector is the third-largest consumer of primary energy in Belgium. This is partly because of the high percentage of old buildings (buildings constructed before 1945) in its building stock ... [more ▼]The building sector is the third-largest consumer of primary energy in Belgium. This is partly because of the high percentage of old buildings (buildings constructed before 1945) in its building stock. Existing international standards on thermal comfort focus primarily on new construction and commercial buildings but tend to overlook old buildings. This study involves a thermal comfort assessment of fully functional (in use) residential buildings constructed before 1945 in Liège (Belgium). The research methodology is based on continuous long term monitoring of the indoor environment (November 2011 to May 2012) and followed by comfort surveys for selected houses in the city. The analysis of the collected data shows that family composition, envelope performance and the occupants' interaction with the indoor environment greatly affected occupant preferences and functioning of the indoor thermal environment. This study reveals that the occupants' interaction with the indoor thermal environment to restore comfortable thermal conditions varies throughout the day, by adjusting the temperature in different rooms of the house at different times of the day. This study argues that modern comfort standards have failed to estimate the comfort level in these old buildings and, if applied, they would lead to under estimation of their thermal comfort. [less ▲]Detailed reference viewed: 48 (16 ULg) Transcriptome-wide distribution and function of RNA hydroxymethylcytosineDelatte, Benjamin; Wang, F; Ngoc, LV et alin Science (2016), 351(6270), 282-285Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the ... [more ▼]Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, revealing hydroxymethylcytosine in the transcripts of many genes, notably in coding sequences, and identify consensus sites for hydroxymethylation. We found that RNA hydroxymethylation can favor mRNA translation. Tet and hydroxymethylated RNA are found to be most abundant in the Drosophila brain, and Tet-deficient fruitflies suffer impaired brain development, accompanied by decreased RNA hydroxymethylation. This study highlights the distribution, localization, and function of cytosine hydroxymethylation and identifies central roles for this modification in Drosophila. [less ▲]Detailed reference viewed: 29 (3 ULg) Color in the urban environment: A user-oriented protocol for chromatic characterization and the development of a parametric typologyNguyen, Ngoc Luan ; Teller, Jacques in Color Research and Application (2016)This article presents a user-oriented protocol that can be used to characterize chromatic attributes of an urban area. A need for both affordable and reliable assessment method of color has been observed ... [more ▼]This article presents a user-oriented protocol that can be used to characterize chromatic attributes of an urban area. A need for both affordable and reliable assessment method of color has been observed in the field of urban design. The challenge is to provide statistical answers to these two questions: how is color organized, how does it develop its own structure in the city? The main purpose of the research is hence to investigate mean color types within the city via the implementation of a characterization tool; an urban area of the four main classes (historic center, periurban housing districts, working-class neighborhoods, and commercial zones) being characterized by a specific color palette, or a layout of specific color types. The developed instrumentation allows the assessment of the homogeneous and consistent features of an urban district. Their characterization protocol was tested through an application to several streets of the city of Liège (Belgium). [less ▲]Detailed reference viewed: 109 (28 ULg) Assessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerioBabayigit, Aslihan; Dinh Duy Thanh, ; Ethirajan, Anitha et alin Scientific Reports (2016), 6Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite solar cells all ... [more ▼]Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite solar cells all contain lead (Pb), which is an unsettling flaw that leads to severe environmental concerns and is therefore a stumbling block envisioning their large-scale application. Aiming for the retention of favorable electro-optical properties, tin (Sn) has been considered the most likely substitute. Preliminary studies have however shown that Sn-based perovskites are highly unstable and, moreover, Sn is also enlisted as a harmful chemical, with similar concerns regarding environment and health. To bring more clarity into the appropriateness of both metals in perovskite solar cells, we provide a case study with systematic comparison regarding the environmental impact of Pb- and Sn-based perovskites, using zebrafish (Danio Rerio) as model organism. Uncovering an unexpected route of intoxication in the form of acidification, it is shown that Sn based perovskite may not be the ideal Pb surrogate. [less ▲]Detailed reference viewed: 254 (31 ULg) Analytical methods used to quantify isoflavones in cow's milk: a reviewDaems, Frédéric ; Romnee, Jean-Michel; Heuskin, Stéphanie et alin Dairy Science and Technology (2016)This paper provides an update and comprehensive review of the analytical methods used for quantifying isoflavones and their metabolites in cow’s milk. Isoflavones are secondary plant metabolites that are ... [more ▼]This paper provides an update and comprehensive review of the analytical methods used for quantifying isoflavones and their metabolites in cow’s milk. Isoflavones are secondary plant metabolites that are similar to 17 β-estradiol in chemical structure. They form one of the most common categories of phytoestrogens. Numerous health benefits have been attributed to isoflavones, but many of these compounds are also considered to be endocrine disruptors, with adverse effects on health. These contradictory trends offer an attractive prospect for future research, and therefore, sensitive and reliable analytical methods are required to clarify various issues about isoflavones. For this review, a structured methodology was used to select 26 relevant articles published between 2005 and 2015 from the Scopus and CAB Abstract databases. The review discusses individual steps of the analytical procedures described in these articles, including sample preparation, instrumental analysis and validation. The most commonly used analytical procedure is sample preparation involving liquid-liquid extraction and an enzymatic hydrolysis step followed by liquid chromatography with mass spectrometry analysis. Currently, however, there is no standardized procedure for the sample preparation and analysis of isoflavones in milk. [less ▲]Detailed reference viewed: 30 (13 ULg) A comparison of two stretching programs for hamstring muscles: A randomized controlled assessor-blinded studyDemoulin, Christophe ; Wolfs, Sébastien ; Chevalier, Madeline et alin Physiotherapy Theory & Practice (2016)Detailed reference viewed: 128 (13 ULg) Effects of regional climate change on brown rust disease in winter wheatJUNK, Jürgen; Kouadio, Louis; Delfosse, Philippe et alin Climatic Change (2016)Projected climate changes will affect wheat crop production both in the main processes of plant growth and development but also in the occurrences and severities of plant diseases. We assessed the ... [more ▼]Projected climate changes will affect wheat crop production both in the main processes of plant growth and development but also in the occurrences and severities of plant diseases. We assessed the potential infection periods of wheat leaf rust (WLR) at two climatologically differentsites in Luxembourg. A threshold-based model, taking hourlyvalues of air temperatures, relative humidity and precipitation during night-time into account, was used for calculating favourable WLR infection days during three periods throughout the cropping season. Field experiments were conducted during the 2003–2013 period at the selected sites. Projected climate data, from a multi model ensemble of regional climate models (spatial resolution 25 km) as well as an additional projection with a higher spatial resolution of 1.3 km, were used for investigating the potential WLR infection periods for two future time spans. Results showed that the infections of WLR were satisfactorily simulated during the development of wheat at both sites for the 2003–2013 period. The probabilities of WLR detection were close to 1 and the critical success index ranged from 0.80 to 0.94 (perfect score = 1 for both). Moreover, the highest proportions of favourable days of WLR infection were simulated during spring and summer at both sites. Regional climate projections showed an increase in temperatures by 1.6 K for 2041–2050 and by 3.7 K for 2091–2100 compared to the reference period1991–2000. Positivetrends infavourableWLR infection conditions occur at both sites more conducive than in the reference period due to projected climatic conditions. [less ▲]Detailed reference viewed: 35 (7 ULg) Collaborative analysis of multi-gigapixel imaging data using CytomineMarée, Raphaël ; Rollus, Loïc; Stévens, Benjamin et alin Bioinformatics (2016)Motivation: Collaborative analysis of massive imaging datasets is essential to enable scientific discoveries. Results: We developed Cytomine to foster active and distributed collaboration of ... [more ▼]Motivation: Collaborative analysis of massive imaging datasets is essential to enable scientific discoveries. Results: We developed Cytomine to foster active and distributed collaboration of multidisciplinary teams for large-scale image-based studies. It uses web development methodologies and machine learning in order to readily organize, explore, share, and analyze (semantically and quantitatively) multi-gigapixel imaging data over the internet. We illustrate how it has been used in several biomedical applications. Availability: Cytomine (http://www.cytomine.be/) is freely available under an open-source license from http://github.com/cytomine/. A documentation wiki (http://doc.cytomine.be) and a demo server (http://demo.cytomine.be) are also available. [less ▲]Detailed reference viewed: 111 (19 ULg) Review of M.G. Vassanji: Essays on His Works (edited by Asma Sayed)Munos, Delphine in South Asian Diaspora (2016), onlineDetailed reference viewed: 26 (2 ULg) Far beyond primary poly(vinylamine)s through free radical copolymerization and amide hydrolysisDréan, Mathilde ; Guégan, Philippe; Jérôme, Christine et alin Polymer Chemistry (2016), 7(1), 69-78Due to their affinity for many supports, their pH responsiveness, metal binding capacity and polyelectro- lyte complexation, poly(vinylamine) derivatives have attracted attention for many applications ... [more ▼]Due to their affinity for many supports, their pH responsiveness, metal binding capacity and polyelectro- lyte complexation, poly(vinylamine) derivatives have attracted attention for many applications including coatings, water purification, or gas membrane separation. Nevertheless, most of them possess only pendant primary amines despite the possible benefits of incorporating different amino groups along the chain. In this work, a straightforward and scalable synthesis route towards polymers bearing primary and secondary amines, as well as imidazole groups, is reported. The general strategy relies on the radical copolymerization of different vinylamides and vinyl imidazoles followed by the hydrolysis of the resulting poly(vinylamide) derivatives. Binary and ternary free radical copolymerizations of N-vinylacetamide (NVA), N-methyl vinylacetamide (NMVA) and 1-vinylimidazole (VIm) were investigated and the reactivity ratios for each copolymerization system were determined. Thanks to these values a series of statistical copolymers with predictable composition and low deviation over the chain distribution could then be synthesized. Finally, the acidic hydrolysis of the acetamide functions towards the corresponding amine was performed and optimized. Copolymers containing various pendant amino groups and with low dispersity in the chain composition could be obtained, which opens new perspectives for the above mentioned applications. [less ▲]Detailed reference viewed: 77 (21 ULg) Belgique : vers un rééquipement des forces arméesDumoulin, André in Revue de Défense nationale (2016)Detailed reference viewed: 5 (0 ULg) Spin texture induced by oxygen vacancies in strontium perovskite (001) surfaces: A theoretical comparison between SrTiO3 and SrHfO3Garcia Castro, Andrés Camilo ; Vergniory, Maia G.; Bousquet, Eric et alin Physical Review B (2016), 93The electronic structure of SrTiO3 and SrHfO3 (001) surfaces with oxygen vacancies is studied by means of first-principles calculations. We reveal how oxygen vacancies within the first atomic layer of the ... [more ▼]The electronic structure of SrTiO3 and SrHfO3 (001) surfaces with oxygen vacancies is studied by means of first-principles calculations. We reveal how oxygen vacancies within the first atomic layer of the SrTiO3 surface (i) induce a large antiferrodistortive motion of the oxygen octahedra at the surface, (ii) drive localized magnetic moments on the Ti 3d orbitals close to the vacancies, and (iii) form a two-dimensional electron gas localized within the first layers. The analysis of the spin texture of this system exhibits a splitting of the energy bands according to the Zeeman interaction, lowering of the Ti 3dxy level in comparison with dxz and dyz, and also an in-plane precession of the spins. No Rashba-like splitting for the ground state or for the ab initio molecular dynamics trajectory at 400 K is recognized as suggested recently by A. F. Santander-Syro et al. [Nat. Mater. 13, 1085 (2014)]. Instead, a sizable Rashba-like splitting is observed when the Ti atom is replaced by a heavier Hf atom with a much larger spin-orbit interaction. However, we observe the disappearance of the magnetism and the surface two-dimensional electron gas when full structural optimization of the SrHfO3 surface is performed. Our results uncover the sensitive interplay of spin-orbit coupling, atomic relaxations, and magnetism when tuning these Sr-based perovskites. [less ▲]Detailed reference viewed: 36 (5 ULg) Determination of the substrate repertoire of ADAMTS2, 3 and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-beta signaling as primary targets.Bekhouche, Mourad ; Leduc, Cédric ; Dupont, Laura et alin FASEB Journal (2016)Detailed reference viewed: 39 (11 ULg) Processing of a new class of multifunctional hybrid for electromagnetic absorption based on a foam filled honeycombBollen, Pierre; Quievy, Nicolas; Detrembleur, Christophe et alin Materials & Design (2016), 89A multifunctional hybrid material class in the form of a sandwich panel has been developed towards the com- bined optimization of mechanical and electromagnetic absorption performance. The faces of the ... [more ▼]A multifunctional hybrid material class in the form of a sandwich panel has been developed towards the com- bined optimization of mechanical and electromagnetic absorption performance. The faces of the panel are made of glass fibre reinforced epoxy composites and the core is made of carbon nanotube reinforced polymer foam filling a metallic honeycomb. The different processing strategies and options tested to fabricate the core material are described aswell as the associated scientific and technological issues. The most efficient processing route is by foaming the nanocomposite with a chemical foaming agent directly inside the honeycomb. This route offers a good surface finish and the operation can be achieved in one step. But, in order to produce large panels with a semi-continuous process, thermo-mechanical insertion of the foamed nanocomposite with supercritical CO2 can be more suitable. The characterization of the electromagnetic absorption of the panels produced by dif- ferent routes shows that the performance is not much sensitive to processing defects making possible upscaling to mass production. [less ▲]Detailed reference viewed: 53 (4 ULg) A prospective cohort study of the clinical presentation of non-traumatic osteonecrosis of the femoral head: spine and knee symptoms as clinical presentation of hip osteonecrosis.HAUZEUR, Jean-Philippe ; Malaise, Michel ; de MARTELAER, vin International Orthopaedics (2016)To study the clinical presentation of femoral head osteonecrosis (ONFH). Publications dedicated to this aspect of ONFH are rare. Our aim was to systematically collect and describe the clinical data.Detailed reference viewed: 26 (5 ULg) Comprehensive comparison of the chemical and structural characterization of landfill leachate and leonardite humic fractionsTahiri, Abdelghani ; Richel, Aurore ; Destain, Jacqueline et alin Analytical and Bioanalytical Chemistry (2016), 408(7), 1917-1928Humic substances (HS) are complex and heterogeneous mixtures of organic compounds that occur everywhere in the environment. They represent most of the dissolved organic matter in soils, sediments (fossil ... [more ▼]Humic substances (HS) are complex and heterogeneous mixtures of organic compounds that occur everywhere in the environment. They represent most of the dissolved organic matter in soils, sediments (fossil), water, and landfills. The exact structure of HS macromolecules has not yet been determined because of their complexity and heterogeneity. Various descriptions of HS are used depending on specific environments of origin and research interests. In order to improve the understanding of the structure of HS extracted from landfill leachate (LHS) and commercial HS from leonardite (HHS), this study sought to compare the composition and characterization of the structure of LHS and HHS using elemental composition, chromatographic (high-performance liquid chromatography (HPLC)), and spectroscopic techniques (UV–vis, FTIR, NMR, and MALDI-TOF). The results showed that LHS molecules have a lower molecular weight and less aromatic structure than HHS molecules. The characteristics of functional groups of both LHS and HHS, however, were basically similar, but there was some differences in absorbance intensity. There were also less aliphatic and acidic functional groups and more aromatic and polyphenolic compounds in the humic acid (HA) fraction than in the fulvic acid (FA) and other molecules (OM) fractions of both origins. The differences between LHS and HHS might be due to the time course of humification. Combining the results obtained from these analytical techniques cold improve our understanding of the structure of HS of different origins and thus enhance their potential use. [less ▲]Detailed reference viewed: 31 (16 ULg) Variability in the super-Earth 55 Cnc eDemory, Brice-Olivier; Gillon, Michaël ; Madhusudhan, Nikku et alin Monthly Notices of the Royal Astronomical Society (2016), 455Considerable progress has been made in recent years in observations of atmospheric signatures of giant exoplanets, but processes in rocky exoplanets remain largely unknown due to major challenges in ... [more ▼]Considerable progress has been made in recent years in observations of atmospheric signatures of giant exoplanets, but processes in rocky exoplanets remain largely unknown due to major challenges in observing small planets. Numerous efforts to observe spectra of super-Earths, exoplanets with masses of 1-10 Earth masses, have thus far revealed only featureless spectra. In this paper, we report a 4σ detection of variability in the dayside thermal emission from the transiting super-Earth 55 Cancri e. Dedicated space-based monitoring of the planet in the mid-infrared over eight eclipses revealed the thermal emission from its dayside atmosphere varying by a factor of 3.7 between 2012 and 2013. The amplitude and trend of the variability are not explained by potential influence of star spots or by local thermal or compositional changes in the atmosphere over the short span of the observations. The possibility of large-scale surface activity due to strong tidal interactions possibly similar to Io, or the presence of circumstellar/circumplanetary material appear plausible and motivate future long-term monitoring of the planet. [less ▲]Detailed reference viewed: 42 (3 ULg) Insan her şeyin ölçüsü şüdür? Çağdas dünya ısiğinda ProtagorasGavray, Marc-Antoine in Sabah Ülkesi (2016), 46Detailed reference viewed: 24 (1 ULg) COSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. XV. Assessing the achievability and precision of time-delay measurementsBonvin, V.; Tewes, M.; Courbin, F. et alin Astronomy and Astrophysics (2016), 585COSMOGRAIL is a long-term photometric monitoring of gravitationally lensed quasars aimed at implementing Refsdal's time-delay method to measure cosmological parameters, in particular H[SUB]0[/SUB]. Given ... [more ▼]COSMOGRAIL is a long-term photometric monitoring of gravitationally lensed quasars aimed at implementing Refsdal's time-delay method to measure cosmological parameters, in particular H[SUB]0[/SUB]. Given the long and well sampled light curves of strongly lensed quasars, time-delay measurements require numerical techniques whose quality must be assessed. To this end, and also in view of future monitoring programs or surveys such as the LSST, a blind signal processing competition named Time Delay Challenge 1 (TDC1) was held in 2014. The aim of the present paper, which is based on the simulated light curves from the TDC1, is double. First, we test the performance of the time-delay measurement techniques currently used in COSMOGRAIL. Second, we analyse the quantity and quality of the harvest of time delays obtained from the TDC1 simulations. To achieve these goals, we first discover time delays through a careful inspection of the light curves via a dedicated visual interface. Our measurement algorithms can then be applied to the data in an automated way. We show that our techniques have no significant biases, and yield adequate uncertainty estimates resulting in reduced χ[SUP]2[/SUP] values between 0.5 and 1.0. We provide estimates for the number and precision of time-delay measurements that can be expected from future time-delay monitoring campaigns as a function of the photometric signal-to-noise ratio and of the true time delay. We make our blind measurements on the TDC1 data publicly available. [less ▲]Detailed reference viewed: 18 (2 ULg) ANIMA: A data-sharing initiative for neuroimaging meta-analysesReid, Andrew T.; Bzdok, Danilo; Genon, Sarah et alin NeuroImage (2016), 124(B), 1245-1253Meta-analytic techniques allow cognitive neuroscientists to pool large amounts of data across many individual task-based functional neuroimaging experiments. These methods have been aided by the ... [more ▼]Meta-analytic techniques allow cognitive neuroscientists to pool large amounts of data across many individual task-based functional neuroimaging experiments. These methods have been aided by the introduction of online databases such as Brainmap.org or Neurosynth.org, which collate peak activation coordinates obtained from thousands of published studies. Findings from meta-analytic studies typically include brain regions which are consistently activated across studies for specific contrasts, investigating cognitive or clinical hypotheses. These regions can be subsequently used as the basis for seed-based connectivity analysis, or formally compared to neuroimaging data in order to help interpret new findings. To facilitate such approaches, we have developed a new online repository of meta-analytic neuroimaging results, named the Archive of Neuroimaging Meta-analyses (ANIMA). The ANIMA platform consists of an intuitive online interface for querying, downloading, and contributing data from published meta-analytic studies. Additionally, to aid the process of organizing, visualizing, and working with these data, we present an open-source desktop application called Volume Viewer. Volume Viewer allows users to easily arrange imaging data into composite stacks, and save these sessions as individual files, which can also be uploaded to the ANIMA database. The application also allows users to perform basic functions, such as computing conjunctions between images, or extracting regions-of-interest or peak coordinates for further analysis. The introduction of this new resource will enhance the ability of researchers to both share their findings and incorporate existing meta-analytic results into their own research. [less ▲]Detailed reference viewed: 22 (3 ULg) Three irradiated and bloated hot Jupiters:. WASP-76b, WASP-82b, and WASP-90bWest, R. G.; Hellier, C.; Almenara, J.-M. et alin Astronomy and Astrophysics (2016), 585We report on three new transiting hot Jupiter planets, discovered from the WASP surveys, which we combine with radial velocities from OHP/SOPHIE and Euler/CORALIE and photometry from Euler and TRAPPIST ... [more ▼]We report on three new transiting hot Jupiter planets, discovered from the WASP surveys, which we combine with radial velocities from OHP/SOPHIE and Euler/CORALIE and photometry from Euler and TRAPPIST. The planets WASP-76b, WASP-82b, and WASP-90b are all inflated, with radii of 1.7-1.8 R[SUB]Jup[/SUB]. All three orbit hot stars, of type F5-F7, with orbits of 1.8-3.9 d, and all three stars have evolved, post-main-sequence radii (1.7-2.2 R[SUB]⊙[/SUB]). Thus the three planets fit a known trend of hot Jupiters that receive high levels of irradiation being highly inflated. We caution, though, about the presence of a selection effect, in that non-inflated planets around ~2 R[SUB]⊙[/SUB] post-MS stars can often produce transits too shallow to be detected by the ground-based surveys that have found the majority of transiting hot Jupiters. Tables of the photometry and radial velocity are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/585/A126 [less ▲]Detailed reference viewed: 26 (2 ULg) Amplitude and frequency variations of oscillation modes in the pulsating DB white dwarf star KIC~08626021. The likely signature of nonlinear resonant mode couplingZong, W.; Charpinet, S.; Vauclair, G. et alin Astronomy and Astrophysics (2016), 585Context. The signatures of nonlinear effects affecting stellar oscillations are difficult to observe from ground observatories because of the lack of continuous high-precision photometric data spanning ... [more ▼]Context. The signatures of nonlinear effects affecting stellar oscillations are difficult to observe from ground observatories because of the lack of continuous high-precision photometric data spanning extended enough time baselines. The unprecedented photometric quality and coverage provided by the Kepler spacecraft offers new opportunities to search for these phenomena. Aims: We use the Kepler data accumulated on the pulsating DB white dwarf KIC 08626021 to explore in detail the stability of its oscillation modes, searching, in particular, for evidence of nonlinear behaviors. Methods: We analyze nearly two years of uninterrupted short-cadence data, concentrating on identified triplets that are caused by stellar rotation and that show intriguing behaviors during the course of the observations. Results: We find clear signatures of nonlinear effects that could be attributed to resonant mode coupling mechanisms. These couplings occur between the components of the triplets and can induce different types of behaviors. We first notice that a structure at 3681 μHz, identified as a triplet in previous published studies, is in fact forming a doublet, with the third component being an independent mode. We find that a triplet at 4310 μHz and this doublet at 3681 μHz (most likely the two visible components of an incomplete triplet) have clear periodic frequency and amplitude modulations, which are typical of the so-called intermediate regime of the resonance, with timescales consistent with theoretical expectations. Another triplet at 5073 μHz is likely in a narrow transitory regime in which the amplitudes are modulated while the frequencies are locked. Using nonadiabatic pulsation calculations, based on a model representative of KIC 08626021 to evaluate the linear growth rates of the modes in the triplets, we also provide quantitative information that could be useful for future comparisons with numerical solutions of the amplitude equations. Conclusions: The observed modulations are the clearest hints of nonlinear resonant couplings occurring in white dwarf stars identified so far. These should resonate as a warning to projects that aim at measuring the evolutionary cooling rate of KIC 08626021, and of white dwarf stars in general. Nonlinear modulations of the frequencies can potentially jeopardize any attempt to measure such rates reliably, unless they can be corrected beforehand. These results should motivate further theoretical work to develop the nonlinear stellar pulsation theory. [less ▲]Detailed reference viewed: 31 (3 ULg) The effects of a documentary film about schizophrenia on cognitive, affective and behavioural aspects of stigmatisationThonon, Bénédicte ; Pletinx, Amandine; Grandjean, Allison et alin Journal of Behavior Therapy and Experimental Psychiatry (2016), 50Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to ... [more ▼]Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to develop interventions aiming to prevent, reduce or eliminate such stereotypes. The aim of this study was to evaluate the effects of a documentary film on schizophrenia on cognitive, affective and behavioural aspects of stigmatisation. Methods: Forty-nine participants were assessed on measures of stereotypes and social distance, and on the Model of Stereotype Content, which includes measures of stereotypes, emotional reactions and behavioural tendencies. Participants were randomly assigned into either a condition in which they viewed the documentary film (Film group), or into a control condition in which no intervention was conducted (Control group). Results: Only participants in the Film group revealed a significant decrease of negative stereotypes (Dangerousness and Unpredictability) and desired Social distance, and a significant increase in the perception of sociability in persons with schizophrenia. Limitations: Small sample size and its reduced generalizability are the main limitations in this study. Conclusions: These findings suggest that a documentary film promoting indirect contact with people diagnosed with schizophrenia is a promising tool to prevent and reduce stigmatisation regarding schizophrenia. [less ▲]Detailed reference viewed: 16 (0 ULg) Osteoporosis and sarcopenia: two diseases or one?Reginster, Jean-Yves ; Beaudart, Charlotte ; Buckinx, Fanny et alin Current Opinion in Clinical Nutrition & Metabolic Care (2016), 19(1), 31-6Purpose of review This article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions. Recent findings Numerous studies ... [more ▼]Purpose of review This article reviews recently published evidence for common pathways explaining bone and muscle wasting in normal ageing and pathological conditions. Recent findings Numerous studies support the concept of a bone–muscle unit, where constant cross-talking between the two tissues takes place, involving molecules released by the skeletal muscle secretome, which affects bone, and osteokines secreted by the osteoblasts and osteocytes, which, in turn, impact muscle cells. Summary New chemical entities aiming at concomitantly treating osteoporosis and sarcopenia could be developed by targeting pathways that centrally regulate bone and muscle or emerging pathways that facilitate the communication between the two tissues. [less ▲]Detailed reference viewed: 16 (2 ULg) LE CAS CLINIQUE DU MOIS Thrombose veineuse ovarienne gauche et extension à la veine rénaleJEAN, FLORENCE; CLAUDOT, A.; ISTACE, B. et alin Revue Médicale de Liège (2016), 71(1), 17-21Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of ... [more ▼]Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of cases. The usual clinical features include abdominal pain, fever and leucocytosis. However, the diagnosis is often complicated by other non specific signs and symptoms. Ovarian vein thrombosis may cause sepsis, pulmonary thromboembolism, and thrombosis of the inferior vena cava and the renal vein. The diagnosis can be established by CT scan or nuclear magnetic resonance imaging, which has a high sensitivity and specificity. Treatment for the ovarian vein thrombosis includes antibiotics and anticoagulation. The complications can sometimes be surgically managed. Prompt diagnosis and treatment can decrease the morbidity and the mortality. Nowadays, the fatal issue is rare as the appropriate treatment is quickly instaured. [less ▲]Detailed reference viewed: 29 (5 ULg) High Prevalence of Plasmodium falciparum Infection in Asymptomatic Individuals from the Democratic Republic of the CongoMvumbi, Dieudonné; Bobanga, Thierry; Melin, Pierrette et alin Malaria Research and Treatment (2016), 2016Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHOMalaria Report in 2014. Asymptomaticmalaria cases are known to be prevalent ... [more ▼]Malaria remains a major public health problem in the Democratic Republic of Congo (DRC) with 14 million cases reported by the WHOMalaria Report in 2014. Asymptomaticmalaria cases are known to be prevalent in endemic areas and are generally untreated,resulting in a significant source of gametocytes that may serve as reservoir of disease transmission. Considering that microscopycertainly underestimates the prevalence of Plasmodium infections within symptomatic carriers and that PCR assays are currentlyrecognized as the most sensitive methods for Plasmodium identification, this study was conducted to weigh the asymptomatic carriage in DRC by a molecular method. Six provinces were randomly selected for blood collection in which 80 to 100 individuals were included in the study. Five hundred and eighty blood sampleswere collected andmolecular diagnosiswas performed. Globally, almost half of the samples collected from asymptomatic individuals (280/580; 48.2%) had Plasmodium infections and the most species identified was P. falciparum alone in combination with P. malariae. The high prevalence reported here should interpellate the bodies involved in malaria control in DR Congo to take into account asymptomatic carriers in actions taken and consider asymptomatic malaria as a major hurdle for malaria elimination. [less ▲]Detailed reference viewed: 18 (1 ULg) Populatieonderzoek naar de Hazelmuis in de VoerstreekVerbeylen, Goedele; Mouton, Alice ; Driessens, Gerald et alin De Levende Natuur (2016), (numero 1), The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation ... [more ▼]The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation and fragmentation the Flemish distribution area of this critically endangered species has been reduced to the eastern part of the municipality of Voeren, where it forms a cross-border population with the Dutch Hazel dormice. Since 2003 the Mammal Working Group of Natuurpunt studies the remaining Flemish population to find out more about population parameters, habitat use, the influence of habitat quality and management actions. In 2007 a standardised monitoring started by counting autumnal nests along fixed transects. In 2013 an intensive capture-mark-recapture study was set up based on nest box and nest tube checks and live-trapping on custom made hanging platforms; also a first test with radiocollars took place. The information gathered from the combination of all these methods will be used to validate the monitoring method and to formulate better protection measures. First results show that late summer and autumn should not be considered as the main reproduction period, at least not in an early year like 2014 when first young were already born at the beginning of May. Hazel dormice do not only cross significant barriers like the railway during dispersal, but also do this regularly during their nightly movements within their home range. Expansion of the population on a location with sufficient connectivity seems to be hampered by a too low population density resulting from insufficient habitat quality and (in this case) a high predation pressure by house cats. On the scale of the Meuse-Rhine Euregion, genetic analyses carried out by the University of Liège reveal four genetically isolated clusters, for which a vision to interconnect these was computed in the Interreg-project ‘Habitat Euregio’. [less ▲]Detailed reference viewed: 26 (0 ULg) Première consultation de contraception chez les adolescentesBELIARD, Aude in Revue Médicale de Liège (2016), 71(1), 28-33Adequate contraception prescription is mandatory for teenagers to avoid any unwanted pregnancy. Counselling and description of side effect improve compliance. Use of condom is important to avoid sexually ... [more ▼]Adequate contraception prescription is mandatory for teenagers to avoid any unwanted pregnancy. Counselling and description of side effect improve compliance. Use of condom is important to avoid sexually transmitted infections. Combined estroprogestin contraception has multiple non-contraceptive benefits, e.g. dysmenorrhea improvement. Familial and personal history is needed before contraception prescription. Further consultation 3 months later has to be planned to evaluate compliance, side effects and to adapt contraception if needed. [less ▲]Detailed reference viewed: 112 (1 ULg) L'intentionnalité cognitive et ses modes. Reinach critique de BrentanoDewalque, Arnaud in Philosophie (2016), 128Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai ... [more ▼]Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai mon attention sur certaines divergences significatives entre Reinach et Brentano. Après quelques réflexions introductives (§§ 1-2), j’examinerai plus exactement les questions suivantes : quels sont les motifs théoriques qui ont conduit Reinach à s’écarter de la théorie brentanienne du jugement (§§ 3-4) ? Et que retenir de ses analyses aujourd’hui (§§ 5-6) ? [less ▲]Detailed reference viewed: 101 (3 ULg) La psychothérapie institutionnelle : un processus thérapeutique au service de la régulation émotionnelle et de l'empathieTriffaux, Jean-Marc ; Gernay, Delphine; Servais, Catherine et alin Encéphale (L') (2016)Detailed reference viewed: 42 (6 ULg) Determinants of vitamin D supplementation prescription in nursing homes: a survey among general practitionersBuckinx, Fanny ; Reginster, Jean-Yves ; Cavalier, Etienne et alin Osteoporosis International (2016), 27Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 ... [more ▼]Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. Introduction The aim of this study is to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Methods General practitioners (GPs) having at least one patient in a nursing home in Liège, Belgium, were asked to complete the survey. Results A total of 119 GPs participated in the survey. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. The main reasons for prescribing vitamin D cited by GPs who do so systematically are as follows: because they believe nursing home residents are mostly deficient in vitamin D status (92.1 %), because they believe that vitamin D supplementation prevents osteoporotic fractures (77.8 %), and because vitamin D supplementation is recommended by various scientific societies (38.1 %). GPs who only prescribe vitamin D supplementation in some patients mainly do so following a diagnosis of osteoporosis (82.4 %), on the basis the 25(OH)D level (78.4 %), in the case of history of fracture (54.9 %) or after a recent fracture (43.4 %). Surprisingly, 16 physicians (31.4 %) only prescribe vitamin D when they think of it. Interestingly, while 40.7% of GPs always prescribe the same dose of vitamin D, the remaining 59.3 % prescribe a dose that will mainly depend on the results of the 25(OH)D level (94.0 %), the patient’s bone health (49.3 %), or history of fracture (43.3 %). Conclusions More than half of GPs systematically prescribe vitamin D to their patients living in nursing homes. The other GPs usually prescribe vitamin D following the result of the vitamin D status or after a diagnosis of osteoporosis. [less ▲]Detailed reference viewed: 49 (26 ULg) Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.Umelo, Ijeoma ; Noeparast, Amir; Chen, Gang et alin Oncotarget (2016), 7(3), 3068-83Somatic mutations found within the tyrosine kinase domain (TKD) of the human epidermal growth factor (HER) family of receptors have been implicated in the development and progression of non-small cell ... [more ▼]Somatic mutations found within the tyrosine kinase domain (TKD) of the human epidermal growth factor (HER) family of receptors have been implicated in the development and progression of non-small cell lung cancer (NSCLC). However, no conclusive reports have described pathogenic mutations in kinase-impaired HER3. Here, we report a case of an advanced chemotherapy-resistant NSCLC, harboring a novel HER3V855A somatic mutation homologous to the EGFRL858Ractivating mutation. Co-expression of HER3V855A and wild-type HER2 enhances ligand-induced transformation of murine and human cell lines, while HER-targeted inhibitors potently suppress mutant HER3 activity. Consistent with these observations, in silico computational modeling predicts that mutant V855A alters the kinase domain and c-terminal end of the HER3 protein. Taken together, these findings provide a basis for the clinical exploration of targeted therapies in HER3 mutant NSCLC and by extrapolation, in other cancers that more frequently carry somatic HER3 mutations. [less ▲]Detailed reference viewed: 26 (1 ULg) Pre-employement examination for low back risk in workers exposesd to manual handling of loads : French guidelinesPETIT, Audrey; ROUSSEAU, Sandrine; HUEZ, Jean-François et alin International Archives of Occupational and Environmental Health (2016), 89Detailed reference viewed: 35 (1 ULg)