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See detailA method for measuring the sensitivity of building structural members to fire decay phases
Gernay, Thomas ULg

in Acta Polytechnica (2016), 56(4), 344-352

Fire brigades face a major threat when intervening in a building in fire: the possibility of structural collapse during the cooling phase of the fire, or soon thereafter. Currently this threat is ... [more ▼]

Fire brigades face a major threat when intervening in a building in fire: the possibility of structural collapse during the cooling phase of the fire, or soon thereafter. Currently this threat is amplified by the fact that the behaviour of structures after the time of peak gas temperature is not well understood, and is not taken into account in the design. This work presents an analysis of the behaviour of different structural members under natural fires and develops a method to characterize their sensitivity to fire decay phases. Thermo-mechanical numerical simulations based on the non-linear finite element method are conducted using the parametric fire model of Eurocode to represent natural fires. Results show that, for all the studied members (column, beam) and materials (reinforced concrete, steel and timber), structural failure during or after the cooling phase of a fire is a possible event. The major factors that promote delayed structural failure are the thermal inertia and the constituting material of the member. A method, based on a new indicator, is proposed to quantify the propensity to delayed failure for structural members under natural fire. This work enhances the understanding of the structural behaviour under natural fires and has important implications for the safety of the fire brigades and people proceeding to a building inspection after a fire. [less ▲]

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See detailBreaking Barriers Between Arts: Bob Dylan’s Nobel Prize
Lombard, David ULg

in Culture, le Magazine Culturel de l'Université de Liège (2016), (10),

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See detailNonlinear dynamical tunneling of optical whispering gallery modes in the presence of a Kerr nonlinearity
Shim, Jeong -Bo ULg; Schlagheck, Peter ULg; Hentschel, Martina et al

in Physical Review A (2016), 94

The effect of a Kerr nonlinearity on dynamical tunneling is studied, using coupled whispering gallery modes in an optical microcavity. The model system that we have chosen is the “add-drop filter,” which ... [more ▼]

The effect of a Kerr nonlinearity on dynamical tunneling is studied, using coupled whispering gallery modes in an optical microcavity. The model system that we have chosen is the “add-drop filter,” which is comprised of an optical microcavity and two waveguides coupled to the cavity. Due to the evanescent fields scattering on the waveguide, the whispering gallery modes in the microcavity form doublets, which manifest themselves as splittings in the spectrum. As these doublets can be regarded as a spectral feature of dynamical tunneling between two different dynamical states with a spatial overlap, the effect of a Kerr nonlinearity on the doublets is numerically investigated in the more general context of the relationship between cubic nonlinearity and dynamical tunneling. Within the numerical realization of the model system, it is observed that the doublets show a bistable transition in their transmission curve as the Kerr nonlinearity in the cavity is increased. At the same time, one rotational mode becomes dominant over the other one in the transmission, since the two states in the doublet have uneven linewidths. By using coupled-mode theory, the underlying mode dynamics of the phenomena is theoretically modeled and clarified. [less ▲]

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See detailEtude transfrontalière des besoins de formation en Education Thérapeutique du Patient souffrant de diabète et/ou d’obésité pour le personnel médical et paramédical : enquête par méthode du groupe nominal
Pétré, Benoît ULg; Ketterer, Frédéric ULg; Vanmeerbeek, Marc ULg et al

in Presse Médicale (2016), 45(10), 351-361

INTRODUCTION: The design of continuous training programs in therapeutic patient education (ETP) should be inspired by needs shown by the professionals concerned in terms of mobilization or acquisition of ... [more ▼]

INTRODUCTION: The design of continuous training programs in therapeutic patient education (ETP) should be inspired by needs shown by the professionals concerned in terms of mobilization or acquisition of skills in this domain. The objective of this study is to analyze needs expressed by healthcare professionals (HP) involved in patients' management presenting a type 2 diabetes (T2D) and/or obesity and to compare them with the existing recommendations. METHODS: One hundred and five PS (general practitioners, dietitians and nurses) of 3 frontier regions of French-speaking European countries (France, Belgium and Grand duchy of Luxembourg) were questioned in 12 monodisciplinary groups according to the technique of the nominal group. Needs expressed by the participants were classified in the categories of the reference table of skills to dispense TPE (National Institute for Health Prevention and Education [INPES], 2013). RESULTS/DISCUSSION: Among needs expressed by HP, 52 % of the votes targeted relational skills, 10 % of the skills relative to the biomedical techniques, 20 % of the skills relative to the educational techniques and 11 %, those of organization and the coordination. Seven percent of the proposals were out of the categories of the INPES. Results do not allow to establish profiles of skills according to the studied region or profession. The recognition of the TPE by the French legislation does not seem to influence in a major way the data. CONCLUSION: The needs expressed by PS in the context of this study are focused on the relation HP/patient that is the heart of the TPE. It would however be necessary to raise awareness among HP in the acquisition of the other skills which concern in particular the animation of group, the interprofessional coordination, the consideration of the environment or more generally the procedures. [less ▲]

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See detailResting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers
BONHOMME, Vincent ULg; VANHAUDENHUYSE, Audrey ULg; Demertzi, Athina ULg et al

in Anesthesiology (2016), 125(5), 873-878

Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control ... [more ▼]

Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing psychedelic dreaming and no apparent interaction with the environment. The authors used functional magnetic resonance imaging to explore ketamine-induced changes in RSNs connectivity. Methods: Fourteen healthy volunteers received stepwise intravenous infusions of ketamine up to loss of responsiveness. Because of agitation, data from six subjects were excluded from analysis. RSNs connectivity was compared between absence of ketamine (wake state [W1]), light ketamine sedation, and ketamine-induced unresponsiveness (deep sedation [S2]). Results: Increasing the depth of ketamine sedation from W1 to S2 altered DMn and SALn connectivity and suppressed the anticorrelated activity between DMn and other brain regions. During S2, DMn connectivity, particularly between the medial prefrontal cortex and the remaining network (effect size β [95% CI]: W1 = 0.20 [0.18 to 0.22]; S2 = 0.07 [0.04 to 0.09]), and DMn anticorrelated activity (e.g., right sensory cortex: W1 = −0.07 [−0.09 to −0.04]; S2 = 0.04 [0.01 to 0.06]) were broken down. SALn connectivity was nonuniformly suppressed (e.g., left parietal operculum: W1 = 0.08 [0.06 to 0.09]; S2 = 0.05 [0.02 to 0.07]). Executive control networks, auditory network, SMn, and visual network were minimally affected. Conclusions: Ketamine induces specific changes in connectivity within and between RSNs. Breakdown of frontoparietal DMn connectivity and DMn anticorrelation and sensory and SMn connectivity preservation are common to ketamine and propofol-induced alterations of consciousness. [less ▲]

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See detailAvoir faim au risque d'en mourir ? Le paradoxe de l'anorexie mentale.
Triffaux, Jean-Marc ULg; Moukhaiber, sophie; PIETTE, Catherine ULg

in Revue Médicale de Liège (2016), 71(11), 495-501

Anorexia nervosa is a complex pathology that regularly leads clinicians to a therapeutic impasse. The origin of this disorder is multifactorial. It occurs most often in adolescence and affects mainly ... [more ▼]

Anorexia nervosa is a complex pathology that regularly leads clinicians to a therapeutic impasse. The origin of this disorder is multifactorial. It occurs most often in adolescence and affects mainly women. Paradoxically, hunger is present but dissociated from adequate food function. Somatic and psychological impact can be particularly heavy. The treatment is difficult and requires a multidisciplinary care. An eclectic and integrative approach, moving away from rigid therapeutic methods and integrating the plurality of techniques, seems to be particularly recommended to increase the chances of therapeutic success. This article summarizes the various theoretical models of anorexia nervosa and its modalities of treatment. [less ▲]

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See detailUse of long bolts for beam-to-concrete-filled rectangular hollow section column joints in seismic-resistant frames
Hoang, Van Long; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

in Steel Construction (2016), 9(4), 305-314

A research on a specific type of unstiffened extended end-plate joint used to connect I-shaped beams to concrete-filled rectangular hollow section columns is presented in this paper. The main idea is to ... [more ▼]

A research on a specific type of unstiffened extended end-plate joint used to connect I-shaped beams to concrete-filled rectangular hollow section columns is presented in this paper. The main idea is to use long bolts throughout the column to connect the beam end-plates, so: (1) avoiding intermediate connecting elements (e.g. a reverse U channel) or special bolts (e.g. blind bolts) that are sometimes used in practice; (2) improving the resistance and stiffness of the joint to be used in seismic resistant frames. Firstly, a test program has been performed within a RFCS European project entitled HSS-SERF “High Strength Steel in Seismic Resistant Building Frames”, 2009-2013. In the test program, specimens subjected to significant bending moments (and shear) or to shear only have been defined. Then, analytical models based on the component approach and aimed at predicting the joint response have been proposed; their validity is demonstrated through comparisons with the test results. Finally, the requirements of EN-1998-1-1 related to full strength resistance for the proposed joint configuration are discussed, accounting for the actual position of plastic hinges and the possible individual over-strength factors for each component. [less ▲]

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See detailResults From Belgium’s 2016 Report Card on Physical Activity for Children and Youth
Wijtzes, Anne I; Verloigne, Maïté; Mouton, Alexandre ULg et al

in Journal of Physical Activity and Health (2016), 13((Suppl 2)), 95-103

This 2016 Belgium Report Card on Physical Activity for Children and Youth is the first systematic evaluation of physical activity (PA) behaviors, related health behaviors, health outcomes, and influences ... [more ▼]

This 2016 Belgium Report Card on Physical Activity for Children and Youth is the first systematic evaluation of physical activity (PA) behaviors, related health behaviors, health outcomes, and influences thereon, using the Active Healthy Kids Canada grading framework. A research working group consisting of PA experts from both Flanders and Wallonia collaborated to determine the indicators to be graded, data sources to be used, and factors to be taken into account during the grading process. Grades were finalized after consensus was reached among the research working group and 2 stakeholder groups consisting of academic and policy experts in the fields of PA, sedentary behavior, and dietary behavior. Eleven indicators were selected and assigned the following grades: Overall PA (F+), Organized Sport Participation (C-), Active Play (C+), Active Transportation (C-), Sedentary Behaviors (D-), School (B-), Government Strategies and Investment (C+), and Weight Status (D). Incomplete grades were assigned to Family and Peers, Community and the Built Environment, and Dietary Behaviors due to a lack of nationally representative data. In conclusion, despite moderately positive social and environmental influences, PA levels of Belgian children and youth are low while levels of sedentary behaviors are high. [less ▲]

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See detailEvaluation of different in vitro dissolution tests based on level A in vitro–in vivo correlations for fenofibrate self-emulsifying lipid-based formulations
Pestieau, Aude ULg; Lebrun, Sonia; Cahay, Bernard et al

in European Journal of Pharmaceutics & Biopharmaceutics (2016)

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See detailExtraction Socket Management with Buccal Plate Expansion: Preliminary Results of a Novel Technique
Fernandez Ayora, Alberto; González-Martín, Oscar; ROMPEN, Eric ULg et al

in International Journal of Periodontics & Restorative Dentistry (2016), 36(6),

The primary objective of this pilot study was to evaluate a new socket preservation technique involving the intentional expansion of the extraction socket buccal plate using a flapless internal ... [more ▼]

The primary objective of this pilot study was to evaluate a new socket preservation technique involving the intentional expansion of the extraction socket buccal plate using a flapless internal corticotomy and biomaterials. A total of 11 patients requiring tooth extraction were enrolled in this study. The aim of this technique was to maintain or improve the hard and soft tissue contour of the ridge after tooth extraction. All surgical sites healed uneventfully. Significant alveolar bone dimension changes were observed in the coronal region of the ridge (-1.4 ± 0.9 mm); however, it was only slightly lower at the medium (-0.35 ± 0.7 mm) and apical levels (-0.3 ± 0.8 mm) (P > .05). The ridge dimensional changes were significantly higher in the buccal aspect than in the palatal aspect in all patients. Vertical bone resorption was not significant. Concerning the soft tissue contour, the horizontal distance between the preoperative and postoperative buccal profiles ranged from 0.94 to -2.88 mm. The proposed ridge preservation technique may help maintain the volume of the healed ridge but cannot completely prevent contour changes after tooth extraction. [less ▲]

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See detailA Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo
Hendricks, Céline; Dubail, Johanne; Brohée, Laura ULg et al

in PLoS ONE (2016)

Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins. It is involved in axonal ... [more ▼]

Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins. It is involved in axonal development, angiogenesis and cancer progression. Its primary mRNA is subjected to alternative splicing mechanisms generating different isoforms, some of which lack the transmembrane domain and display antagonist properties to NRP1 full size (FS). NRP1 is further post-translationally modified by the addition of glycosaminoglycans (GAG) side chains through an O-glycosylation site at serine612. Here, we characterized a novel splice variant which has never been investigated, NRP1-Δ7, differing from the NRP1-FS by a deletion of 7 amino acids occurring two residues downstream of the O-glycosylation site. This short sequence contains two aspartic residues critical for efficient glycosylation. As expected, the high molecular weight products appearing as a smear in SDS-PAGE and reflecting the presence of GAG in NRP1-FS were undetectable in the NRP1-Δ7 protein. NRP1-Δ7 mRNA was found expressed at an appreciable level, between 10 and 30% of the total NRP1, by various cells lines and tissues from human and murine origin. To investigate the biological properties of this isoform, we generated prostatic (PC3) and breast (MDA-MB-231) cancer cells able to express recombinant NRP1-FS or NRP1-Δ7 in a doxycycline-inducible manner. Cells with increased expression of NRP1-Δ7 were characterized in vitro by a significant reduction of proliferation, migration and anchorage-independent growth, while NRP1-FS had the expected opposite “pro-tumoral” effects. Upon VEGF-A165 treatment, a lower internalization rate was observed for NRP1-Δ7 than for NRP1-FS. Finally, we showed that NRP1-Δ7 inhibited growth of prostatic tumors and their vascularization in vivo. This report identifies NRP1-Δ7 as a splice variant displaying anti-tumorigenic properties in vitro and in vivo, emphasizing the need to consider this isoform in future studies. [less ▲]

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See detailIncidence and Phenotype at Diagnosis of Very-early-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease: A Population-based Study [1988-2011].
Bequet, Emeline ULg; Sarter, Hélène; Fumery, Mathurin et al

in Journal of Crohn's and Colitis [=JCC] (2016)

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See detailLacunes extrinsèques et effets au contentieux préjudiciel : lorsque la Cour de cassation fait d'une pierre deux coups
Pironnet, Quentin ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), 35(2016), 1652-1658

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See detailEffects of interactions on the relaxation processes in magnetic nanostructures
Atkinson, Lewis; Ostler, Thomas ULg; Ondrej, Hovorka et al

in Physical Review. B: Condensed Matter and Materials Physics (2016), 94

Controlling the relaxation of magnetization in magnetic nanostructures is key to optimizing magnetic storage device performance. This relaxation is governed by both intrinsic and extrinsic relaxation ... [more ▼]

Controlling the relaxation of magnetization in magnetic nanostructures is key to optimizing magnetic storage device performance. This relaxation is governed by both intrinsic and extrinsic relaxation mechanisms and with the latter strongly dependent on the interactions between the nanostructures. In the present work we investigate laser induced magnetization dynamics in a broadband optical resonance type experiment revealing the role of interactions between nanostructures on the relaxation processes of granular magnetic structures. The results are corroborated by constructing a temperature dependent numerical micromagnetic model of magnetization dynamics based on the Landau-Lifshitz-Bloch equation. The model predicts a strong dependence of damping on the key material properties of coupled granular nanostructures in good agreement with the experimental data. We show that the intergranular, magnetostatic and exchange interactions provide a large extrinsic contribution to the damping. Finally we show that the mechanism can be attributed to an increase in spin-wave degeneracy with the ferromagnetic resonance mode as revealed by semianalytical spin-wave calculations. [less ▲]

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See detailBollywood et les limites du soft power indien
Vlassis, Antonios ULg

in Telos (electronic journal) (2016)

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See detailA near-infrared interferometric survey of debris-disc stars. V. PIONIER search for variability
Ertel, S.; Defrere, Denis ULg; Absil, Olivier ULg et al

in Astronomy and Astrophysics (2016), 595

Context. Extended circumstellar emission has been detected within a few 100 milli-arcsec around ≳10% of nearby main sequence stars using near-infrared interferometry. Follow-up observations using other ... [more ▼]

Context. Extended circumstellar emission has been detected within a few 100 milli-arcsec around ≳10% of nearby main sequence stars using near-infrared interferometry. Follow-up observations using other techniques, should they yield similar results or non-detections, can provide strong constraints on the origin of the emission. They can also reveal the variability of the phenomenon. Aims: We aim to demonstrate the persistence of the phenomenon over the timescale of a few years and to search for variability of our previously detected excesses. Methods: Using Very Large Telescope Interferometer (VLTI)/Precision Integrated Optics Near Infrared ExpeRiment (PIONIER) in H band we have carried out multi-epoch observations of the stars for which a near-infrared excess was previously detected using the same observation technique and instrument. The detection rates and distribution of the excesses from our original survey and the follow-up observations are compared statistically. A search for variability of the excesses in our time series is carried out based on the level of the broadband excesses. Results: In 12 of 16 follow-up observations, an excess is re-detected with a significance of > 2σ, and in 7 of 16 follow-up observations significant excess (> 3σ) is re-detected. We statistically demonstrate with very high confidence that the phenomenon persists for the majority of the systems. We also present the first detection of potential variability in two sources. Conclusions: We conclude that the phenomenon responsible for the excesses persists over the timescale of a few years for the majority of the systems. However, we also find that variability intrinsic to a target can cause it to have no significant excess at the time of a specific observation. [less ▲]

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See detailCompetition between finite-size effects and dipole–dipole interactions in few-atom systems
Damanet, François ULg; Martin, John ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2016), 49

In this paper, we study the competition between finite-size effects (i.e. discernibility of particles) and dipole–dipole interactions in few-atom systems coupled to the electromagnetic field in vacuum. We ... [more ▼]

In this paper, we study the competition between finite-size effects (i.e. discernibility of particles) and dipole–dipole interactions in few-atom systems coupled to the electromagnetic field in vacuum. We consider two hallmarks of cooperative effects, superradiance and subradiance, and compute for each the rate of energy radiated by the atoms and the coherence of the atomic state during the time evolution. We adopt a statistical approach in order to extract the typical behaviour of the atomic dynamics and average over random atomic distributions in spherical containers with prescribed k0 R with k0 the radiation wavenumber and R the average interatomic distance. Our approach allows us to highlight the tradeoff between finite-size effects and dipole– dipole interactions in superradiance/subradiance. In particular, we show the existence of an optimal value of k0R for which the superradiant intensity and coherence pulses are the less affected by dephasing effects induced by dipole–dipole interactions and finite-size effects. [less ▲]

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See detailInterspecific variation of warning calls in piranhas: a comparative analysis
Melotte, Geoffrey ULg; Vigouroux, Régis; Michel, Christian ULg et al

in Scientific Reports (2016)

Fish sounds are known to be species-specific, possessing unique temporal and spectral features. We have recorded and compared sounds in eight piranha species to evaluate the potential role of acoustic ... [more ▼]

Fish sounds are known to be species-specific, possessing unique temporal and spectral features. We have recorded and compared sounds in eight piranha species to evaluate the potential role of acoustic communication as a driving force in clade diversification. All piranha species showed the same kind of sound-producing mechanism: sonic muscles originate on vertebrae and attach to a tendon surrounding the bladder ventrally. Contractions of the sound-producing muscles force swimbladder vibration and dictate the fundamental frequency. It results the calling features of the eight piranha species logically share many common characteristics. In all the species, the calls are harmonic sounds composed of multiple continuous cycles. However, the sounds of Serrasalmus elongatus (higher number of cycles and high fundamental frequency) and S. manueli (long cycle periods and low fundamental frequency) are clearly distinguishable from the other species. The sonic mechanism being largely conserved throughout piranha evolution, acoustic communication can hardly be considered as the main driving force in the diversification process. However, sounds of some species are clearly distinguishable despite the short space for variations supporting the need for specific communication. Behavioural studies are needed to clearly understand the eventual role of the calls during spawning events. [less ▲]

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See detailIn-utero coxsackievirus B4 infection of the mouse thymus
Jaïdane, Hela; Halouani, Aymen; Jmii, H. et al

in Clinical & Experimental Immunology (2016), Sous presse

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes ... [more ▼]

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis or Sjo€gren’s syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in-utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance. In this perspective, female Swiss albino mice were inoculated intraperitoneally or orally with the diabetogenic CV-B4 E2 strain at gestational days 10 or 17. Offspring were killed at different post-inoculation times, and their thymuses were analysed for evidence of infection and alterations in thymic T cell subsets. In-utero CV-B infection of the thymus was demonstrated during the course of vertical transmission, as attested by viral RNA and infectious virus detection in most analysed samples. No histopathological changes were evident. Thymic T cells were not depleted, despite being positive for viral RNA. As evidenced by flow cytometry analysis, CV-B infection of the fetal thymus induced significant changes of thymic T cell populations, particularly with maternal inoculation at gestational day 10. Altogether, these findings suggest that CV-B infection of the fetal thymus may play an important role in the genesis of autoimmune diseases. [less ▲]

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See detailSurface- and redox-active multifunctional polyphenol-derived poly(ionic liquid)s: controlled synthesis and characterization
Patil, Nagaraj ULg; Cordella, Daniela; Aqil, Abdelhafid ULg et al

in Macromolecules (2016), 49(20), 7676-7691

Combining the redox activity and remarkable adhesion propensity of polyphenols (such as catechol or pyrogallol) with the numerous tunable properties of poly(ionic liquid)s (PILs) is an attractive route to ... [more ▼]

Combining the redox activity and remarkable adhesion propensity of polyphenols (such as catechol or pyrogallol) with the numerous tunable properties of poly(ionic liquid)s (PILs) is an attractive route to design inventive multifunctional macro-molecular platforms. In this contribution, we describe the first synthesis of a novel family of structurally well-defined PILs functionalized with catechol/pyrogallol/phenol pendants by organometallic-mediated radical polymerization (OMRP) using an alkyl−cobalt(III) complex as initiator and mediating agent. The living character of the chains is also exploited to produce di-and triblock PILs, and the facile counteranion exchange reactions afforded a library of PILs-bearing free phenol/catechol/pyrogallol moieties. Electrochemical investigations of catechol/pyrogallol-derived PILs in aqueous medium demonstrated the characteristic catechol to o-quinone transformations, whereas, quasi-reversible doping/undoping with supporting electrolyte cations (Li + /tetrabutylammonium +) has been observed in organic media, suggesting a bright future for this new family of redox-active PILs as cathode material for secondary energy storage devices. Also, pendant catechol/pyrogallol groups mediated sustained anchoring onto the gold surface conferred PILs properties to the interface. As a proof-of-concept, both the adsorption and inhibition of proteins on polymer modified surfaces have been demonstrated in real time using the quartz crystal microbalance with dissipation technique. The exquisite physicochemical tunability of these innovative surface-and redox-active PILs makes them excellent candidates for a broad range of potential applications, including " smart surfaces " and electrochemical energy storage devices. [less ▲]

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See detailVelocimetry of superconducting vortices based on stroboscopic resonances
Jelic, Zeljko ULg; Milosevic, Milorad; Silhanek, Alejandro ULg

in Scientific Reports (2016), 6

An experimental determination of the mean vortex velocity in superconductors mostly relies on the measurement of flux-flow resistance with magnetic field, temperature, or driving current. In the present ... [more ▼]

An experimental determination of the mean vortex velocity in superconductors mostly relies on the measurement of flux-flow resistance with magnetic field, temperature, or driving current. In the present work we introduce a method combining conventional transport measurements and a frequency-tuned flashing pinning potential to obtain reliable estimates of the vortex velocity. The proposed device is characterized using the time-dependent Ginzburg-Landau formalism, where the velocimetry method exploits the resonances in mean vortex dissipation when temporal commensuration occurs between the vortex crossings and the flashing potential. We discuss the sensitivity of the proposed technique on applied current, temperature and heat diffusion, as well as the vortex core deformations during fast motion. [less ▲]

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See detailMyoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
Blomme, Arnaud; Costanza, Brunella ULg; De Tullio, Pascal ULg et al

in Oncogene (2016)

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as ... [more ▼]

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells. We have previously demonstrated that myoferlin regulates epidermal growth factor receptor activity in breast cancer. In the current study, we report a consistent overexpression of myoferlin in triple-negative breast cancer cells (TNBC) over cells originating from other breast cancer subtypes. Using a combination of proteomics, metabolomics and electron microscopy, we demonstrate that myoferlin depletion results in marked alteration of endosomal system and metabolism. Mechanistically, myoferlin depletion caused impaired vesicle traffic that led to a misbalance of saturated/unsaturated fatty acids. This provoked mitochondrial dysfunction in TNBC cells. As a consequence of the major metabolic stress, TNBC cells rapidly triggered AMP activated protein kinase-mediated metabolic reprogramming to glycolysis. This reduced their ability to balance between oxidative phosphorylation and glycolysis, rendering TNBC cells metabolically inflexible, and more sensitive to metabolic drug targeting in vitro. In line with this, our in vivo findings demonstrated a significantly reduced capacity of myoferlin-deficient TNBC cells to metastasise to lungs. The significance of this observation was further supported by clinical data, showing that TNBC patients whose tumors overexpress myoferlin have worst distant metastasis-free and overall survivals. This novel insight into myoferlin function establishes an important link between vesicle traffic, cancer metabolism and progression, offering new diagnostic and therapeutic concepts to develop treatments for TNBC patients. [less ▲]

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See detailSU(3) Clebsch-Gordan coefficients at large $N_c$
Stancu, Floarea ULg

in Nuclear Physics A (2016), 945

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic ... [more ▼]

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic formulae derived by Hecht in 1965 in the context of nuclear physics. This is valid for irreducible representations with multiplicity one in the corresponding Clebsch-Gordan series. For multiplicity two, Hecht has proposed an alternative which can provide correct $1/N_c$ sub-leading orders in large $N_c$ studies. [less ▲]

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See detailImpact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
LAMBERT, France ULg; Bacevic, Miljana ULg; Layrolle, Pierre et al

in Clinical Oral Implants Research (2016)

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite ... [more ▼]

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (HA) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods: Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite (SHA) sintered at high temperature were characterised with scanning electronic microscopy (SEM) and the measurement of specific surface area (BET). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non-decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results: The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities (P = 0.0017; BHA vs. SHA, P = 0.0018 and CBHA vs. SHA, P = 0.033) at 5 and 12 weeks compared to the synthetic one (SHA). Moreover, the osteoconductivity (bone-to-material contact) was significantly higher in the BHA group compared to the two other groups (P = 0.014; BHA vs. SHA, P = 0.023 and BHA vs. CBHA, P = 0.033). Conclusion: HA-based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone-to-material contacts were found with BHA. [less ▲]

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See detailBiomasse et stocks de carbone des forêts tropicales africaines (synthèse bibliographique)
Loubota Panzou, Grâce Jopaul ULg; Doucet, Jean-Louis ULg; Loumeto, Jean-Joël et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(4), 508-522

Introduction. Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated at ... [more ▼]

Introduction. Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated at three successive levels: the tree, the stand and the region level. This paper reviews the state of the art regarding the estimation of biomass and carbon stocks in tropical African forests. Literature. This review highlights the fact that very few allometric equations, equations used for estimating the biomass of the tree using non-destructive measurements (diameter, height), have been established for tropical African forests. At the stand level, the review highlights the spatial and temporal variations in biomass between forest types in Central and Eastern Africa. While biomass recovery after a disturbance (logging, for instance) is rather quick, a great deal of uncertainty still remains regarding the spatial variation in biomass, and there is no consensus on a regional biomass map. The quality of biomass mapping in tropical Africa strongly depends on the type of remotely-sensed data being used (optical, RADAR or LIDAR), and the allometric equation used to convert forest inventory data into biomass. Conclusions. Based on the lack of precision of the available allometric equations and forest inventory data and the large spatial scale involved, many uncertainties persist in relation to the estimation of the biomass and carbon stocks contained in African tropical forests. [less ▲]

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See detailThe influence of flight style on the aerodynamic properties of avian wings as fixed lifting surfaces
Lees, John J.; Dimitriadis, Grigorios ULg; Nudds, Robert L.

in PeerJ (2016), 4:e2495

The diversity of wing morphologies in birds reflects their variety of flight styles and the associated aerodynamic and inertial requirements. Although the aerodynamics underlying wing morphology can be ... [more ▼]

The diversity of wing morphologies in birds reflects their variety of flight styles and the associated aerodynamic and inertial requirements. Although the aerodynamics underlying wing morphology can be informed by aeronautical research, important differences exist between planes and birds. In particular, birds operate at lower, transitional Reynolds numbers than do most aircraft. To date, few quantitative studies have investigated the aerodynamic performance of avian wings as fixed lifting surfaces and none have focused upon the differences between wings from different flight style groups. Dried wings from 10 bird species representing 3 distinct flight style groups were mounted on a force/torque sensor within a wind tunnel in order to test the hypothesis that wing morphologies associated with different flight styles exhibit different aerodynamic properties. Morphological differences manifested primarily as differences in drag rather than lift. Maximum lift coefficients did not differ between groups, whereas minimum drag coefficients were lowest in undulating flyers (Corvids). The lift to drag ratios were lower than in conventional aerofoils and data from free-flying soaring species; particularly in high frequency, flapping flyers (Anseriformes), which do not rely heavily on glide performance. The results illustrate important aerodynamic differences between the wings of different flight style groups that cannot be explained solely by simple wing-shape measures. Taken at face value, the results also suggest that wing-shape is linked principally to changes in aerodynamic drag, but, of course, it is aerodynamics during flapping and not gliding that is likely to be the primary driver. [less ▲]

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See detailEtest® versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: results from PREMIUM, a European multicentre study.
CANTON, Rafael; LVERMORE, David M; MOROSINI, Maria Isabel et al

in Journal of Antimicrobial Chemotherapy (2016)

OBJECTIVES: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a ... [more ▼]

OBJECTIVES: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a European multicentre study. METHODS: Ceftaroline MICs were determined by reference BMD and by Etest for 1242 MSSA and MRSA isolates collected between February and May 2012 from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour. RESULTS: Overall concordance between BMD and Etest was good, with >97% essential agreement and >95% categorical agreement. Nevertheless, 12 of the 26 MRSA isolates found resistant by BMD scored as susceptible by Etest, with MICs ≤1 mg/L, thus counting as very major errors, whereas only 5 of 380 MRSA isolates found ceftaroline susceptible in BMD were miscategorized as resistant by Etest. Twenty-one of the 26 isolates with MICs of 2 mg/L by BMD were then retested twice by each of three central laboratories: BMD MICs of 2 mg/L were consistently found for 19 of the 21 isolates. Among 147 Etest results for these 21 isolates (original plus six repeats per isolate) 112 were >1 mg/L. CONCLUSIONS: BMD and Etest have good overall agreement for ceftaroline against Staphylococcus aureus; nevertheless, reliable Etest-based discrimination of the minority of ceftaroline-resistant (MIC 2 mg/L) MRSA is extremely challenging, requiring careful reading of strips, ideally with duplicate testing. [less ▲]

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See detailLettuce (Lactuca sativa L. var. Sucrine) Growth Performance in Complemented Aquaponic Solution Outperforms Hydroponics
Delaide, Boris; Goddek, Simon; Gott, James et al

in Water (2016), 8(467),

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See detailThe closure of arteriovenous fistula in kidney transplant recipients is associated with an acceleration of kidney function decline
WEEKERS, Laurent ULg; VANDERWECKENE, Pauline ULg; pottel, hans et al

in Nephrology Dialysis Transplantation (2016)

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney ... [more ▼]

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney transplant recipients (KTRs) remains unknown. Methods. From 2007 to 2013, we retrospectively categorized 285 KTRs into three groups: no AVF (Group 0, n = 90), closed AVF (Group 1, n = 114) and left-open AVF (Group 2, n = 81). AVF closure occurred at 653 ± 441 days after kidney transplantation (KTx), with a thrombosis:ligation ratio of 19:95. Estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Disease equation. Linear mixed models calculated the slope and intercept of eGFR decline versus time, starting at 3 months post-KTx, with a median follow-up of 1807 days (95% confidence interval 1665–2028). Results. The eGFR slope was less in Group 1 (−0.081 mL/min/ month) compared with Group 0 (−0.183 mL/min/month; P = 0.03) or Group 2 (−0.164 mL/min/month; P = 0.09). Still, the eGFR slope significantly deteriorated after (−0.159 mL/min/month) versus before (0.038 mL/min/month) AVF closure (P= 0.03). Study periods before versus after AVF closure were balanced to a mean of 13.5 and 12.5 months, respectively, with at least 10 observations per patient (n = 99). Conclusions. In conclusion, a significant acceleration of eGFR decline is observed over the 12 months following the closure of a functioning AVF in KTRs. [less ▲]

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See detailLe régime disciplinaire appliqué aux internés : irresponsables au pénal, responsables au disciplinaire ?
Michiels, Olivier ULg; Nederlandt, Olivia

in Journal des Tribunaux (2016), (6660), 561-570

La loi de principes du 12 janvier 2005 organise un régime disciplinaire au sein des établissements pénitentiaires avec pour objectif le maintien de l'ordre et de la sécurité. Ce régime s'applique aux ... [more ▼]

La loi de principes du 12 janvier 2005 organise un régime disciplinaire au sein des établissements pénitentiaires avec pour objectif le maintien de l'ordre et de la sécurité. Ce régime s'applique aux internés détenus en prison. Déclarer des internés responsables d'avoir commis des infractions disciplinaires pose cependant question, dès lors que la mesure d'internement signifie qu'ils ont préalablement été déclarés irresponsables de leurs actes. Cet article présente le régime disciplinaire appliqué en prison, en abordant différentes questions relatives aux infractions disciplinaires, portant sur leur nature juridique, leur élément moral et leur imputabilité aux internés. [less ▲]

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See detailHépatite C. Dépister largement...et guérir!
DELWAIDE, Jean ULg

in Le Journal du Médecin (2016), (2467), 20-21

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See detailZones de défection temporaire. Refigurations de Bartleby et de des Esseintes dans quelques romans contemporains
Claisse, Frédéric ULg; Huppe, Justine ULg

in TRANS : Revue de Littérature Générale et Comparée (2016), 20

Concerned by the exploitation of narrative and fiction for commercial or strategic purposes, many writers and observers wonder what power literature still has today, when the logic of capitalism took over ... [more ▼]

Concerned by the exploitation of narrative and fiction for commercial or strategic purposes, many writers and observers wonder what power literature still has today, when the logic of capitalism took over its tools and seems always one step ahead of its critical potentialities. To use Albert Hirschman’s terminology, if the possibilities of voice seem exhausted, can the same be said of the exit strategy, in a networked world precisely fortified by the constant injunction to freedom and autonomy? Moving the issue to the field of the novel, our contribution focuses on some contemporary characters’ wish to withdraw (geeks, secluded artists, autonomous activists, hermits of the virtual age, etc.), compared to emblematic literary figures of exit in the XIXth century (des Esseintes, Bartleby, Oblomov, Emma Bovary), so as to measure the changes that affected the very space of possibilities of exit, and their consequences for forms of resistance in literature. [less ▲]

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See detailInfluence of short-term synoptic events and snow depth on DMS, DMSP, and DMSO dynamics in Antarctic spring sea ice
Carnat, Gauthier; Brabant, Frédéric; Dumont, Isabelle et al

in Elementa: Science of the Anthropocene (2016), 4(0), 000135

Temporal changes in the concentration profiles of dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO) were measured in pack ice from the Bellingshausen Sea (Antarctica ... [more ▼]

Temporal changes in the concentration profiles of dimethylsulfide (DMS), dimethylsulfoniopropionate (DMSP), and dimethylsulfoxide (DMSO) were measured in pack ice from the Bellingshausen Sea (Antarctica) during the winter-spring transition of 2007. Two sites with contrasting snow and ice thicknesses were sampled, with high concentrations of DMS, DMSP, and DMSO observed at both sites, especially in surface ice. These high concentrations were shown to correspond to the development of a surface ice microalgal community dominated by strong DMSP producers (flagellates and dinoflagellates) following flooding of the ice cover. Several short-term synoptic events were observed and shown to influence strongly the dynamics of sea ice DMS, DMSP, and DMSO. In particular, a cold spell event was associated with drastic changes in the environmental conditions for the sea ice microbial communities and to a remarkable increase in the production of dimethylated sulfur compounds at both sites. A good correlation between all dimethylated sulfur compounds, sea ice temperature, and brine salinity suggested that the observed increase was triggered mainly by increased thermal and osmotic stresses on microalgal cells. Atmospheric forcing, by controlling sea ice temperature and hence the connectivity and instability of the brine network, was also shown to constrain the transfer of dimethylated sulfur compounds in the ice towards the ocean via brine drainage. Analysis of the two contrasting sampling sites shed light on the key role played by the snow cover in the sea ice DMS cycle. Thicker snow cover, by insulating the underlying sea ice, reduced the amplitude of environmental changes associated with the cold spell, leading to a weaker physiological response and DMS, DMSP, and DMSO production. Thicker snow also hampered the development of steep gradients in sea ice temperature and brine salinity, thereby decreasing the potential for the release of dimethylated sulfur compounds to the ocean via brine drainage. [less ▲]

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See detail68Ga and 188Re Starch-Based Microparticles as Theranostic Tool for the Hepatocellular Carcinoma: Radiolabeling and Preliminary In Vivo Rat Studies
Verger, Elise ULg; Drion, Pierre ULg; MEFFRE, Geneviève ULg et al

in PLoS ONE (2016)

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain ... [more ▼]

This work aims to develop, validate and optimize the radiolabeling of Starch-Based Microparticles (SBMP) by 188Re and 68Ga in the form of ready-to-use radiolabeling kits, the ultimate goal being to obtain a unique theranostic vector for the treatment of Hepatocellular Carcinoma. METHODS: Optimal labeling conditions and composition of freeze-dried kits were defined by monitoring the radiochemical purity while varying several parameters. In vitro stability studies were carried out, as well as an in vivo biodistribution as a preliminary approach with the intra-arterial injection of 68Ga radiolabeled SBMP into the hepatic artery of DENA-induced rats followed by PET/CT imaging. RESULTS: Kits were optimized for 188Re and 68Ga with high and stable radiochemical purity (>95% and >98% respectively). The in vivo preliminary study was successful with more than 95% of activity found in the liver and mostly in the tumorous part. CONCLUSION: SBMP are a promising theranostic agent for the Selective Internal Radiation Therapy of Hepatocellular carcinoma [less ▲]

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See detailA daily, 1 km resolution data set of downscaled Greenland ice sheet surface mass balance (1958–2015)
Noel, B.; van de Berg, W. J.; Machguth, H. et al

in Cryosphere (The) (2016), 10

This study presents a data set of daily, 1 km resolution Greenland ice sheet (GrIS) surface mass balance (SMB) covering the period 1958–2015. Applying corrections for elevation, bare ice albedo and ... [more ▼]

This study presents a data set of daily, 1 km resolution Greenland ice sheet (GrIS) surface mass balance (SMB) covering the period 1958–2015. Applying corrections for elevation, bare ice albedo and accumulation bias, the high-resolution product is statistically downscaled from the native daily output of the polar regional climate model RACMO2.3 at 11 km. The data set includes all individual SMB components projected to a down-sampled version of the Greenland Ice Mapping Project (GIMP) digital elevation model and ice mask. The 1 km mask better resolves narrow ablation zones, valley glaciers, fjords and disconnected ice caps. Relative to the 11 km product, the more detailed representation of isolated glaciated areas leads to increased precipitation over the southeastern GrIS. In addition, the downscaled product shows a significant increase in runoff owing to better resolved low-lying marginal glaciated regions. The combined corrections for elevation and bare ice albedo markedly improve model agreement with a newly compiled data set of ablation measurements. [less ▲]

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See detailDroplet formation by squeezing in a microfluidic cross-junction
Van Loo, Stéphanie ULg; Stoukatch, Serguei ULg; Kraft, Michael ULg et al

in Microfluidics and Nanofluidics (2016), 20(10), 1-12

In microfluidics, flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. We here report an experimental study of droplet formation in a microfluidic cross ... [more ▼]

In microfluidics, flow focusing is widely used to produce water-in-oil droplets in microchannels at high frequency. We here report an experimental study of droplet formation in a microfluidic cross-junction with a minimum number of geometrical parameters. We mostly focus on the squeezing regime, which is composed of two distinct steps : filling and pinching. The duration of each step (and corresponding volumes of each liquid phase) are analyzed. They vary according to both water and oil flow rates. These variations provide several insights about the fluid flows in both phases. We propose several scaling laws to relate the droplet volume and frequency to the flow rate of both phases. We also discuss the influence of surfactant and channel compliance on droplet formation. [less ▲]

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See detailCerebral Activity Associated with Transient Sleep-Facilitated Reduction in Motor Memory Vulnerability to Interference
Albouy, Geneviève; King, Bradley; Schmidt, Christina ULg et al

in Scientific Reports (2016), 6

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See detailExocomet signatures around the A-shell star φ Leonis?
Eiroa, C.; Rebollido, I.; Montesinos, B. et al

in Astronomy and Astrophysics (2016), 594

We present an intensive monitoring of high-resolution spectra of the Ca ii K line in the A7IV shell star φ Leo at very short (minutes, hours), short (night to night), and medium (weeks, months) timescales ... [more ▼]

We present an intensive monitoring of high-resolution spectra of the Ca ii K line in the A7IV shell star φ Leo at very short (minutes, hours), short (night to night), and medium (weeks, months) timescales. The spectra show remarkable variable absorptions on timescales of hours, days, and months. The characteristics of these sporadic events are very similar to most that are observed toward the debris disk host star β Pic, which are commonly interpreted as signs of the evaporation of solid, comet-like bodies grazing or falling onto the star. Therefore, our results suggest the presence of solid bodies around φ Leo. To our knowledge, with the exception of β Pic, our monitoring has the best time resolution at the mentioned timescales for a star with events attributed to exocomets. Assuming the cometary scenario and considering the timescales of our monitoring, our results indicate that φ Leo presents the richest environment with comet-like events known to date, second only to β Pic. [less ▲]

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See detailNovel structures for optimal space partitions
Opsomer, Eric ULg; Vandewalle, Nicolas ULg

in New Journal of Physics (2016)

Partitioning space into polyhedra with a minimum total surface area is a fundamental question in science and mathematics. In 1887, Lord Kelvin conjectured that the optimal partition of space is obtained ... [more ▼]

Partitioning space into polyhedra with a minimum total surface area is a fundamental question in science and mathematics. In 1887, Lord Kelvin conjectured that the optimal partition of space is obtained with a 14-faced space-filling polyhedron, called tetrakaidecahedron. Kelvin’s conjecture resisted a century until Weaire and Phelan proposed in 1994 a new structure, made of eight polyhedra, obtained from numerical simulations. Herein, we propose a stochastic method for finding efficient polyhedral structures, maximizing the mean isoperimeter Q, instead of minimizing total area. We show that novel optimal structures emerge with non-equal cell volumes and uncurved facets. A partition made of 24 polyhedra, is found to surpass the previous known structures. Our work suggests that other structures with high isoperimeter values are still to be discovered in the pursuit of optimal space partitions. [less ▲]

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See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in European Heart Journal (2016), 37(38), 2893-2962

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See detailProspective, long-term study of the effect of cabergoline on valvular status in patients with prolactinoma and idiopathic hyperprolactinemia.
VROONEN, Laurent ULg; Lancellotti, Patrizio ULg; Garcia, Monica Tome et al

in Endocrine (2016)

Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated ... [more ▼]

Since the 1990's cabergoline has been the treatment of choice in prolactinoma, as it permits rapid and effective hormonal and tumor control in most cases. Evidence of cardiac valvulopathy was demonstrated in Parkinson's disease patients treated with dopamine agonists. Retrospective studies in prolactinoma patients treated with cabergoline at lower doses did not show such an effect. However, few prospective data with long-term follow-up are available. The aim of this study was to assess the safety of cabergoline regarding cardiac valvular status during prospective follow-up in patients treated for prolactinoma or idiopathic hyperprolactinemia. We report here a series of 100 patients (71F; median age at diagnosis: 41.5 years) treated with cabergoline for endocrine diseases (prolactinoma n = 89, idiopathic hyperprolactinemia n = 11). All patients underwent complete transthoracic echocardiographic studies at baseline and during long-term prospective surveillance using the same equipment and performed by the same technicians. The median interval between baseline and last follow-up echocardiographic studies while on cabergoline was 62.5 months (interquartile range: 34.75-77.0). The median total duration of cabergoline treatment was 124.5 months (interquartile range: 80.75-188.75) and the median cumulative total dose of cabergoline was 277.8 mg (interquartile range : 121.4-437.8 mg) at last follow-up. We found no clinically relevant alterations in cardiac valve function or valvular calcifications with cabergoline treatment. Our data suggest that findings from retrospective analyses are correct and that cabergoline is a safe chronic treatment at the doses used typically in endocrinology. [less ▲]

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See detailElastic scattering of vortex electrons provides direct access to the Coulomb phase
Ivanov, Igor ULg; Seipt, Daniel; Surzhykov, Andrey et al

in Physical Review. D : Particles and Fields (2016), 94(7), 076001

Vortex electron beams are freely propagating electron waves carrying adjustable orbital angular momentum with respect to the propagation direction. Such beams were experimentally realized just a few years ... [more ▼]

Vortex electron beams are freely propagating electron waves carrying adjustable orbital angular momentum with respect to the propagation direction. Such beams were experimentally realized just a few years ago and are now used to probe various electromagnetic processes. So far, these experiments used the single vortex electron beams, either propagating in external fields or impacting a target. Here, we investigate the elastic scattering of two such aligned vortex electron beams and demonstrate that this process allows one to experimentally measure features which are impossible to detect in the usual plane-wave scattering. The scattering amplitude of this process is well approximated by two plane-wave scattering amplitudes with different momentum transfers, which interfere and give direct experimental access to the Coulomb phase. This phase (shift) affects the scattering of all charged particles and has thus received significant theoretical attention but was never probed experimentally. We show that a properly defined azimuthal asymmetry, which has no counterpart in plane-wave scattering, allows one to directly measure the Coulomb phase as function of the scattering angle. [less ▲]

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See detailMaize plants can enter a standby mode to cope with chilling stress
Riva-Roveda, Laetitia ULg; Escale, Brigitte; Giauffret, Catherine et al

in BMC Plant Biology (2016), 16

Background European Flint maize inbred lines are used as a source of adaptation to cold in most breeding programs in Northern Europe. A deep understanding of their adaptation strategy could thus provide ... [more ▼]

Background European Flint maize inbred lines are used as a source of adaptation to cold in most breeding programs in Northern Europe. A deep understanding of their adaptation strategy could thus provide valuable clues for further improvement, which is required in the current context of climate change. We therefore compared six inbreds and two derived Flint x Dent hybrids for their response to one-week at low temperature (10°C day/7 or 4°C night) during steady-state vegetative growth. Results Leaf growth was arrested during chilling treatment but recovered fast upon return to warm temperature, so that no negative effect on shoot biomass was measured. Gene expression analyses of the emerging leaf in the hybrids suggest that plants maintained a ‘ready-to-grow’ state during chilling since cell cycle genes were not differentially expressed in the division zone and genes coding for expansins were on the opposite up-regulated in the elongation zone. In photosynthetic tissues, a strong reduction in PSII efficiency was measured. Chilling repressed chlorophyll biosynthesis; we detected accumulation of the precursor geranylgeranyl chlorophyll a and down-regulation of GERANYLGERANYL REDUCTASE (GGR) in mature leaf tissues. Excess light energy was mostly dissipated through fluorescence and constitutive thermal dissipation processes, rather than by light-regulated thermal dissipation. Consistently, only weak clues of xanthophyll cycle activation were found. CO2 assimilation was reduced by chilling, as well as the expression levels of genes encoding phosphoenolpyruvate carboxylase (PEPC), pyruvate orthophosphate dikinase (PPDK), and the small subunit of Rubisco. Accumulation of sugars was correlated with a strong decrease of the specific leaf area (SLA). Conclusions Altogether, our study reveals good tolerance of the photosynthetic machinery of Northern European maize to chilling and suggests that growth arrest might be their strategy for fast recovery after a mild stress. [less ▲]

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See detailScreening for the metabolic syndrome in subjects with migraine
Streel, Sylvie ULg; Donneau, Anne-Françoise ULg; Dardenne, Nadia ULg et al

in Cephalalgia : An International Journal of Headache (2016)

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See detailDistributed learning: Developing a predictive model based on data from multiple hospitals without data leaving the hospital – A real life proof of concept
JOCHEMS, Arthur; DEIST, Timo M.; VAN SOEST, Johan et al

in Radiotherapy & Oncology (2016)

Purpose: One of the major hurdles in enabling personalized medicine is obtaining sufficient patient data to feed into predictive models. Combining data originating from multiple hospitals is difficult ... [more ▼]

Purpose: One of the major hurdles in enabling personalized medicine is obtaining sufficient patient data to feed into predictive models. Combining data originating from multiple hospitals is difficult because of ethical, legal, political, and administrative barriers associated with data sharing. In order to avoid these issues, a distributed learning approach can be used. Distributed learning is defined as learning from data without the data leaving the hospital. Patients and methods:Clinical data from 287 lung cancer patients, treated with curative intent with chemoradiation (CRT) or radiotherapy (RT) alone were collected from and stored in 5 different medical institutes (123 patients at MAASTRO (Netherlands, Dutch), 24 at Jessa (Belgium, Dutch), 34 at Liege (Belgium, Dutch and French), 48 at Aachen (Germany, German) and 58 at Eindhoven (Netherlands, Dutch)). A Bayesian network model is adapted for distributed learning (watch the animation: http://youtu.be/nQpqMIuHyOk). The model predicts dyspnea, which is a common side effect after radiotherapy treatment of lung cancer. Results:We show that it is possible to use the distributed learning approach to train a Bayesian network model on patient data originating from multiple hospitals without these data leaving the individual hospital. The AUC of the model is 0.61 (95%CI, 0.51–0.70) on a 5-fold cross-validation and ranges from 0.59 to 0.71 on external validation sets. Conclusion: Distributed learning can allow the learning of predictive models on data originating from multiple hospitals while avoiding many of the data sharing barriers. Furthermore, the distributed learning approach can be used to extract and employ knowledge from routine patient data from multiple hospitals while being compliant to the various national and European privacy laws. [less ▲]

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See detailApsidal motion in the massive binary HD 152218
Rauw, Grégor ULg; Rosu, S.; Noels-Grötsch, Arlette ULg et al

in Astronomy and Astrophysics (2016), 594(A33), 1-12

Massive binary systems are important laboratories in which to probe the properties of massive stars and stellar physics in general. In this context, we analysed optical spectroscopy and photometry of the ... [more ▼]

Massive binary systems are important laboratories in which to probe the properties of massive stars and stellar physics in general. In this context, we analysed optical spectroscopy and photometry of the eccentric short-period early-type binary HD 152218 in the young open cluster NGC 6231. We reconstructed the spectra of the individual stars using a disentangling code. The individual spectra were then compared with synthetic spectra obtained with the CMFGEN model atmosphere code. We furthermore analysed the light curve of the binary and used it to constrain the orbital inclination and to derive absolute masses of (19.8 ± 1.5) and (15.0 ± 1.1) M⊙. Combining radial velocity measurements from over 60 yr, we show that the system displays apsidal motion at a rate of (2.04 ± .24)°/yr. Solving the Clairaut-Radau equation, we used stellar evolution models, obtained with the CLES code, to compute the internal structure constants and to evaluate the theoretically predicted rate of apsidal motion as a function of stellar age and primary mass. In this way, we determine an age of 5.8 ± 0.6 Myr for HD 152218, which is towards the higher end of, but compatible with, the range of ages of the massive star population of NGC 6231 as determined from isochrone fitting. [less ▲]

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See detailDiscovery of WASP-113b and WASP-114b, two inflated hot-Jupiters with contrasting densities
Barros, S. C. C.; Brown, D. J. A.; Hébrard, G. et al

in Astronomy and Astrophysics (2016), 593

We present the discovery and characterisation of the exoplanets WASP-113b and WASP-114b by the WASP survey, {\it SOPHIE} and {\it CORALIE}. The planetary nature of the systems was established by ... [more ▼]

We present the discovery and characterisation of the exoplanets WASP-113b and WASP-114b by the WASP survey, {\it SOPHIE} and {\it CORALIE}. The planetary nature of the systems was established by performing follow-up photometric and spectroscopic observations. The follow-up data were combined with the WASP-photometry and analysed with an MCMC code to obtain system parameters. The host stars WASP-113 and WASP-114 are very similar. They are both early G-type stars with an effective temperature of $\sim 5900\,$K, [Fe/H]$\sim 0.12$ and $T_{\rm eff}$ $\sim 4.1$dex. However, WASP-113 is older than WASP-114. Although the planetary companions have similar radii, WASP-114b is almost 4 times heavier than WASP-113b. WASP-113b has a mass of $0.48\,$ $\mathrm{M}_{\rm Jup}$ and an orbital period of $\sim 4.5\,$days; WASP-114b has a mass of $1.77\,$ $\mathrm{M}_{\rm Jup}$ and an orbital period of $\sim 1.5\,$days. Both planets have inflated radii, in particular WASP-113 with a radius anomaly of $\Re=0.35$. The high scale height of WASP-113b ($\sim 950$ km ) makes it a good target for follow-up atmospheric observations. [less ▲]

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See detailThe Effect of Nutrients on the Degradation of Hydrocarbons in Mangrove Ecosystems by Microorganisms
Semboung Lang, Firmin ULg; Tarayre, Cédric ULg; Destain, Jacqueline ULg et al

in International Journal of Environmental Research (2016), 10(4), 583-592

Mangrove ecosystems are areas prone to various types of pollution, especially hydrocarbons. These hydrocarbons mostly stem from human activities such as spills coming from offshore oil operations, runoff ... [more ▼]

Mangrove ecosystems are areas prone to various types of pollution, especially hydrocarbons. These hydrocarbons mostly stem from human activities such as spills coming from offshore oil operations, runoff from surrounding urban areas or atmospheric deposition. This pollution causes the decline of mangroves, which results in an imbalance in the functioning of this particular ecosystem with damages to the microbiota. Biodegradation allows to restore these ecosystems. This biodegradation can only be effective in specific environmental conditions. The presence of nutrients, which stimulate bacterial growth and promote biodegradation, is a key parameter to be considered. During this experiment, we achieved biodegradation tests to assess the effect of nitrogen and phosphorus on the process. The results showed that the biodegradation rates were strongly bound to the presence of nutrients. The degradation rates depended on the medium. The treatment that reached the best rate of degradation of diesel after 10 days was the one using 20% of a nutrient solution (MSM) containing nitrogen and phosphorus. This treatment led to a maximal degradation of 84.7% ± 4.7% obtained in the flasks containing 20% of a nutrient solution (MSM) containing nitrogen and phosphorus. [less ▲]

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See detailA Stochastic Multi-Scale Approach for the Modeling of Thermo-Elastic Damping in Micro-Resonators
Wu, Ling ULg; Lucas, Vincent ULg; Nguyen, Van Dung ULg et al

in Computer Methods in Applied Mechanics & Engineering (2016), 310

The aim of this work is to study the thermo-elastic quality factor (Q) of micro-resonators with a stochastic multi-scale approach. In the design of high-Q micro-resonators, thermo-elastic damping is one ... [more ▼]

The aim of this work is to study the thermo-elastic quality factor (Q) of micro-resonators with a stochastic multi-scale approach. In the design of high-Q micro-resonators, thermo-elastic damping is one of the major dissipation mechanisms, which may have detrimental effects on the quality factor, and has to be predicted accurately. Since material uncertainties are inherent to and unavoidable in micro-electromechanical systems (MEMS), the effects of those variations have to be considered in the modeling in order to ensure the required MEMS performance. To this end, a coupled thermo-mechanical stochastic multi-scale approach is developed in this paper. Thermo-mechanical micro-models of polycrystalline materials are used to represent micro-structure realizations. A computational homogenization procedure is then applied on these statistical volume elements to obtain the stochastic characterizations of the elasticity tensor, thermal expansion, and conductivity tensors at the meso-scale. Spatially correlated meso-scale random fields can thus be generated to represent the stochastic behavior of the homogenized material properties. Finally, the distribution of the thermo-elastic quality factor of MEMS resonators is studied through a stochastic finite element method using as input the generated stochastic random field. [less ▲]

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See detailTracing back the evolution of the candidate LBV HD 168625
Mahy, Laurent ULg; Hutsemekers, Damien ULg; Royer, P. et al

in Astronomy and Astrophysics (2016), 594

Context. The luminous blue variable phase is a crucial transitory phase that is not clearly understood in the massive star evolution. <BR /> Aims: We have obtained far-infrared Herschel/PACS imaging and ... [more ▼]

Context. The luminous blue variable phase is a crucial transitory phase that is not clearly understood in the massive star evolution. <BR /> Aims: We have obtained far-infrared Herschel/PACS imaging and spectroscopic observations of the nebula surrounding the candidate LBV HD 168625. By combining these data with optical spectra of the central star, we want to constrain the abundances in the nebula and in the star and compare them to trace back the evolution of this object. <BR /> Methods: We use the CMFGEN atmosphere code to determine the fundamental parameters and the CNO abundances of the central star whilst the abundances of the nebula are derived from the emission lines present in the Herschel/PACS spectrum. <BR /> Results: The far-infrared images show a nebula composed of an elliptical ring/torus of ejecta with a ESE-WNW axis and of a second perpendicular bipolar structure composed of empty caps/rings. We detect equatorial shells composed of dust and ionized material with different sizes when observed at different wavelengths, and bipolar caps more of less separated from the central star in Hα and mid-IR images. This complex global structure seems to show two different inclinations: ~40° for the equatorial torus and ~ 60° for the bipolar ejections. From the Herschel/PACS spectrum, we determine nebular abundances of N/H = 4.1 ± 0.8 × 10[SUP]-4[/SUP] and , as well as a mass of ionized gas of 0.17 ± 0.04 M[SUB]⊙[/SUB] and a neutral hydrogen mass of about 1.0 ± 0.3 M[SUB]⊙[/SUB] which dominates. Analysis of the central star reveals T[SUB]eff[/SUB] = 14 000 ± 2000 K, log g = 1.74 ± 0.05 and log (L/L[SUB]⊙[/SUB]) = 5.58 ± 0.11. We derive stellar CNO abundances of about N/H = 5.0 ± 1.5 × 10[SUP]-4[/SUP], C/H = 1.4 ± 0.5 × 10[SUP]-4[/SUP] and O/H = 3.5 ± 1.0 × 10[SUP]-4[/SUP], not significantly different from nebular abundances. All these measurements taken together are compatible with the evolutionary tracks of a star with an initial mass between 28 and 33 M[SUB]⊙[/SUB] and with a critical rotational rate between 0.3 and 0.4 that has lost its material during or just after the blue supergiant phase. Based in part on observations taken by Herschel satellite. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, in Chile. [less ▲]

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See detailA large strain hyperelastic viscoelastic-viscoplastic-damage constitutive model based on a multi-mechanism non-local damage continuum for amorphous glassy polymers
Nguyen, Van Dung ULg; Lani, Frédéric; Pardoen, Thomas et al

in International Journal of Solids and Structures (2016), 96

A large strain hyperelastic phenomenological constitutive model is proposed to model the highly nonlinear, rate-dependent mechanical behavior of amorphous glassy polymers under isothermal conditions. A ... [more ▼]

A large strain hyperelastic phenomenological constitutive model is proposed to model the highly nonlinear, rate-dependent mechanical behavior of amorphous glassy polymers under isothermal conditions. A corotational formulation is used through the total Lagrange formalism. At small strains, the viscoelastic behavior is captured using the generalized Maxwell model. At large strains beyond a viscoelastic limit characterized by a pressure-sensitive yield function, which is extended from the Drucker-Prager one, a viscoplastic region follows. The viscoplastic flow is governed by a non-associated Perzyna-type flow rule incorporating this pressure-sensitive yield function and a quadratic flow potential in order to capture the volumetric deformation during the plastic process. The stress reduction phenomena arising from the post-peak plateau and during the failure stage are considered in the context of a continuum damage mechanics approach. The post-peak softening is modeled by an internal scalar, so-called softening variable, whose evolution is governed by a saturation law. When the softening variable is saturated, the rehardening stage is naturally obtained since the isotropic and kinematic hardening phenomena are still developing. Beyond the onset of failure characterized by a pressure-sensitive failure criterion, the damage process leading to the total failure is controlled by a second internal scalar, so-called failure variable. The final failure occurs when the failure variable reaches its critical value. To avoid the loss of solution uniqueness when dealing with the continuum damage mechanics formalism, a non-local implicit gradient formulation is used for both the softening and failure variables, leading to a multi-mechanism non-local damage continuum. The pressure sensitivity considered in both the yield and failure conditions allows for the distinction under compression and tension loading conditions. It is shown through experimental comparisons that the proposed constitutive model has the ability to capture the complex behavior of amorphous glassy polymers, including their failure. [less ▲]

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See detailAdvancing the integration of corporate sustainability measurement, management and reporting
Maas, Karen; Schaltegger, Stefan; Crutzen, Nathalie ULg

in Journal of Cleaner Production (2016), 133

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See detailTowards a large scale aqueous sol-gel synthesis of doped TiO2: Study of various metallic dopings for the photocatalytic degradation of p-nitrophenol
Mahy, Julien ULg; Lambert, Stéphanie ULg; Léonard, Géraldine ULg et al

in Journal of Photochemistry and Photobiology A : Chemistry (2016), 329

In this paper, an easy aqueous sol-gel synthesis developed previously by Mahy et al. [J. Sol-Gel Sci. Technol. (2016)] is adapted to produce highly active TiO2 catalysts doped with Fe3+, Ag+, Cu2+, Zn2 ... [more ▼]

In this paper, an easy aqueous sol-gel synthesis developed previously by Mahy et al. [J. Sol-Gel Sci. Technol. (2016)] is adapted to produce highly active TiO2 catalysts doped with Fe3+, Ag+, Cu2+, Zn2+, Cr3+, Al3+, Mn2+, and Co2+ ions and Pt metallic nanoparticles. Samples are characterized by inductively coupled plasma–atomic emission spectroscopy (ICP-AES), X-ray diffraction (XRD), Mössbauer spectroscopy, transmission electron microscopy (TEM), nitrogen adsorption–desorption measurements and diffuse reflectance spectroscopy measurements. Results show that the samples are composed of anatase-brookite TiO2 nanoparticles with a spherical shape and mean diameter of around 5-8 nm and a surface area of between about 150 - 250 m2 g-1. In each doped sample, the dopant is present in the form added during the synthesis, given that the sample has not undergone any particular treatment. Photoactivity tests show improvement in catalyst activity for Fe3+, Ag+, Cu2+, Zn2+, and Al3+ ion and Pt metallic nanoparticle dopants, while a decrease of activity is obtained for Cr3+, Mn2+ and Co2+ ion dopants. For some dopants, the activity of TiO2 doped with metallic ions and synthesized from the aqueous sol-gel process is equal or superior to the activity of the commercial photocatalyst Degussa P25. Some mechanisms are proposed to explain these modifications of activity with doping. Furthermore, cost comparison at laboratory scale showed that Zn and Cu nitrate salt dopings are clearly less expensive for a halogen light (UV/visible) or low energy light enhanced catalyst and may be considered for industrial applications. Using this method, a large scale Zn-doped TiO2 photocatalyst is synthesized with properties homologous to the lab-scale product. Results show that the aqueous sol-gel synthesis developed previously can be easily adapted for doping in order to produce an up-scalable synthesis. [less ▲]

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See detailX-ray and optical spectroscopy of the massive young open cluster IC 1805
Rauw, Grégor ULg; Nazé, Yaël ULg

in Astronomy and Astrophysics (2016), 594(A82), 19

Context. Very young open clusters are ideal places to study the X-ray properties of a homogeneous population of early-type stars. In this respect, the IC 1805 open cluster is very interesting as it hosts ... [more ▼]

Context. Very young open clusters are ideal places to study the X-ray properties of a homogeneous population of early-type stars. In this respect, the IC 1805 open cluster is very interesting as it hosts the O4 If+ star HD 15570 thought to be in an evolutionary stage intermediate between a normal O-star and a Wolf-Rayet star. Aims: Such a star could provide a test for theoretical models aiming at explaining the empirical scaling relation between the X-ray and bolometric luminosities of O-type stars. Methods: We have observed IC 1805 with XMM-Newton and further collected optical spectroscopy of some of the O-star members of the cluster. Results: The optical spectra allow us to revisit the orbital solutions of BD+60° 497 and HD 15558, and provide the first evidence of binarity for BD+60° 498. X-ray emission from colliding winds does not appear to play an important role among the O-stars of IC 1805. Notably, the X-ray fluxes do not vary significantly between archival X-ray observations and our XMM-Newton pointing. The very fast rotator BD+60° 513, and to a lesser extent the O4 If+ star HD 15570 appear somewhat underluminous. Whilst the underluminosity of HD 15570 is only marginally significant, its amplitude is found to be compatible with theoretical expectations based on its stellar and wind properties. A number of other X-ray sources are detected in the field, and the brightest objects, many of which are likely low-mass pre-main sequence stars, are analyzed in detail. [less ▲]

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See detailFacteurs d’ambiance dans l’industrie textile en République Démocratique du Congo: état de lieu
Panda Lukongo, Kitronza ULg; Mairiaux, Philippe ULg

in Pan African Medical Journal (The) (2016), 25(44),

Introduction: This case study aims to make an assessment of environmental health nuisances in textile industry in the Democratic Republic of Congo. Methods: We conducted a cross-sectional and analytical ... [more ▼]

Introduction: This case study aims to make an assessment of environmental health nuisances in textile industry in the Democratic Republic of Congo. Methods: We conducted a cross-sectional and analytical study. Out of 257 workers selected using systematic sampling, 229 workers were enrolled in the study. 223 workstations were subjected to measurements in order to determine the level of noise, lighting and heat. Data were collected from company documents, by means of a direct-question interview focusing on socio professional informations and through measurements. Descriptive analysis was used for sociodemographic and professional data and analytical approach was used for themeasurements. Results: In the company studied 88% of employees were workers. Weaving department included almost 68% of workers. The majority of employees worked as part of a three shift (85%). The study population was predominantly male (85%), aging (52%) over 40 years and educated (80%). In the company studied, only 12.1% of workstations met the noise standards and 18% of workstations met the lighting standards. 94% of workstations didn't meet the heat standards for heavy work. Conclusion: Our study highlighted the environmental health nuisances in textile industry, demonstrating the existence of significant gaps related to the prescribed standards for the measured nuisances. These results are a plea for the development of appropriate preventive measures. They should be confronted with other more detailed studies in this work environment. [less ▲]

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See detailActive network management for electrical distribution systems: problem formulation, benchmark, and approximate solution
Gemine, Quentin ULg; Ernst, Damien ULg; Cornélusse, Bertrand ULg

in Optimization and Engineering (2016)

With the increasing share of renewable and distributed generation in electrical distribution systems, active network management (ANM) becomes a valuable option for a distribution system operator to ... [more ▼]

With the increasing share of renewable and distributed generation in electrical distribution systems, active network management (ANM) becomes a valuable option for a distribution system operator to operate his system in a secure and cost-effective way without relying solely on network reinforcement. ANM strategies are short-term policies that control the power injected by generators and/or taken off by loads in order to avoid congestion or voltage issues. While simple ANM strategies consist in curtailing temporary excess generation, more advanced strategies rather attempt to move the consumption of loads to anticipated periods of high renewable generation. However, such advanced strategies imply that the system operator has to solve large-scale optimal sequential decision-making problems under uncertainty. The problems are sequential for several reasons. For example, decisions taken at a given moment constrain the future decisions that can be taken, and decisions should be communicated to the actors of the system sufficiently in advance to grant them enough time for implementation. Uncertainty must be explicitly accounted for because neither demand nor generation can be accurately forecasted. We first formulate the ANM problem, which in addition to be sequential and uncertain, has a nonlinear nature stemming from the power flow equations and a discrete nature arising from the activation of power modulation signals. This ANM problem is then cast as a stochastic mixed-integer nonlinear program, as well as second-order cone and linear counterparts, for which we provide quantitative results using state of the art solvers and perform a sensitivity analysis over the size of the system, the amount of available flexibility, and the number of scenarios considered in the deterministic equivalent of the stochastic program. To foster further research on this problem, we make available at http://www.montefiore.ulg.ac.be/~anm/ three test beds based on distribution networks of 5, 33, and 77 buses. These test beds contain a simulator of the distribution system, with stochastic models for the generation and consumption devices, and callbacks to implement and test various ANM strategies. [less ▲]

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See detailAutologous osteoblastic cells (PREOBy) versus concentrated bone marrow implantation in osteonecrosis of the femoral head: A randomized study
HAUZEUR, Jean-Philippe ULg; Tungouz, Michel; LECHANTEUR, Chantal ULg et al

in Revue de Chirurgie Orthopédique et Traumatologique (2016), 102(Issue 7), 73

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou ... [more ▼]

In non-traumatic osteonecrosis of the femoral head (ONFH), implantation of bone marrow concentrate (BMC) containing mesenchymal stem cells (MSC) could delay ONFH progression and improve symptoms (Hernigou 2002, Gangji 2004). The next step was to assess the hypothesis that a population of autologous osteoblastic cells (OB) consisting in a more differentiated cell than MSC, could be more efficacious than BMC in early stages ON. [less ▲]

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See detailJournée mondiale du Diabète: ne jamais baisser les bras
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailUse of Tyrosine Kinase Inhibitors to Prevent Relapse After Allogeneic Hematopoietic Stem Cell Transplantation for Patients With Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Position Statement of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Giebel, S.; Czyz, A.; Ottmann, O. et al

in Cancer (2016), 122(19), 2941-2951

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL). The introduction of tyrosine kinase inhibitors (TKIs) to first-line therapy has improved overall outcomes; however, a significant proportion of patients still relapse after alloHSCT. Posttransplant TKI maintenance was demonstrated to reduce the risk of relapse in a large retrospective study and, therefore, should be considered a valuable option. This consensus paper, written on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, presents an overview of clinical studies on the use of TKIs after alloHSCT and proposes practical recommendations regarding the choice of TKI, treatment timing, and dosage. It is hoped that these recommendations will become the state of art in this field and, more importantly, lead to a reduction of Ph-positive ALL relapse after alloHSCT. [less ▲]

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See detailAction and Reaction: Effects of Country-based Trade Sanctions
Colussi, Ilaria Anna ULg

in Strategic Trade Review (2016), 2(3), 103-120

Trade sanctions consist of export restrictions and embargoes, or import or customs restrictions, and boycotts. Such measures, which can be adopted at the international, regional or national level, are ... [more ▼]

Trade sanctions consist of export restrictions and embargoes, or import or customs restrictions, and boycotts. Such measures, which can be adopted at the international, regional or national level, are economic tools for achieving foreign policy objectives. The effects that they produce are several, and they cover the political, economic and social spheres. This article analyzes the possible consequences of trade sanctions, in particular embargoes addressing targeted states, in order to evaluate their effectiveness. Two case studies of sanctions, the Iranian and the Russian case, are presented. [less ▲]

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See detailTempus fugit
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailA Great Era Comes to an End: And a New One Begins!
Kolh, Philippe ULg; Dick, F.

in European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (2016), 52(4), 423-424

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See detailConjoint influence of mind-wandering and sleepiness on task performance
Stawarczyk, David ULg; D'Argembeau, Arnaud ULg

in Journal of Experimental Psychology. Human Perception & Performance (2016), 42(10), 1587-15600

Recent research suggests that sleepiness and mind-wandering—the experience of thoughts that are both stimulus-independent and task-unrelated—frequently co-occur and are both associated with poorer ... [more ▼]

Recent research suggests that sleepiness and mind-wandering—the experience of thoughts that are both stimulus-independent and task-unrelated—frequently co-occur and are both associated with poorer cognitive functioning. Whether these two phenomena have distinguishable effects on task performance remains unknown, however. To investigate this question, we employed the online experience sampling of mind-wandering episodes and subjective sleepiness during a laboratory task (the Sustained Attention to Response Task; SART), and also assessed mind-wandering frequency and sleep-related disturbances in daily life using self-report questionnaires. The results revealed that the tendency to experience mind-wandering episodes during the SART and daily life was associated with higher levels of daytime sleepiness and sleep-related disturbances. Importantly, however, mind-wandering and sleepiness were independent predictors of SART performance at both the within- and between-individuals levels. These findings demonstrate that, although mind-wandering and sleepiness frequently co-occur, these two phenomena have distinguishable and additive effects on task performance. [less ▲]

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See detailSarcopenia in daily practice: assessment and management
Beaudart, Charlotte ULg; McCloskey, Eugène; Bruyère, Olivier ULg et al

in BMC Geriatrics (2016), 16(170),

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools ... [more ▼]

Background: Sarcopenia is increasingly recognized as a correlate of ageing and is associated with increased likelihood of adverse outcomes including falls, fractures, frailty and mortality. Several tools have been recommended to assess muscle mass, muscle strength and physical performance in clinical trials. Whilst these tools have proven to be accurate and reliable in investigational settings, many are not easily applied to daily practice. Methods: This paper is based on literature reviews performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) working group on frailty and sarcopenia. Face-to-face meetings were afterwards organized for the whole group to make amendments and discuss further recommendations. Results: This paper proposes some user-friendly and inexpensive methods that can be used to assess sarcopenia in real-life settings. Healthcare providers, particularly in primary care, should consider an assessment of sarcopenia in individuals at increased risk; suggested tools for assessing risk include the Red Flag Method, the SARC-F questionnaire, the SMI method or different prediction equations. Management of sarcopenia should primarily be patient centered and involve the combination of both resistance and endurance based activity programmes with or without dietary interventions. Development of a number of pharmacological interventions is also in progress. Conclusions: Assessment of sarcopenia in individuals with risk factors, symptoms and/or conditions exposing them to the risk of disability will become particularly important in the near future. [less ▲]

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See detailTerrestrial photogrammetry: a non-destructive method for modelling irregularly shaped tropical tree trunks
Bauwens, Sébastien ULg; Lejeune, Philippe ULg; Fayolle, Adeline ULg

in Methods in Ecology and Evolution (2016)

1. Irregularly shaped trees including trees with buttresses, flutes or stilt roots are frequent in tropical forests. The lack of an international standard tomeasure the diameter of such trees leads to ... [more ▼]

1. Irregularly shaped trees including trees with buttresses, flutes or stilt roots are frequent in tropical forests. The lack of an international standard tomeasure the diameter of such trees leads to high uncertainties in biomass estimation, tree growth and carbon budget monitoring. 2. In this study, we developed a new method based on terrestrial close-range photogrammetry for measuring andmodelling irregular stems. This approach is cheap and easy to implement in the field as it only requires a camera and a graduated rod. We validated the approach with destructive cross-sectionmeasurements along the stem of three buttressed trees. To demonstrate the broader utility of this method, we extended the validated approach to 43 additional trees belonging to two species: Celtis mildbraedii (Ulmaceae) and Entandophragma cylindricum (Meliaceae). Based on the three dimensional models, we computed shape indices for each tree, and we analysed the stem morphology of the two species. Finally, we analysed some standardized predictors for the estimation of above-ground biomass. 3. We found a high concordance between diameters derived from the photogrammetric process and destructive diameter measurements along the stem for the three calibration trees. We found that C. mildbraedii develop much stronger irregularities than E. cylindricum.We also identified a large intraspecific variation in trunk morphology for E. cylindricum. The basal area at 1 3 mheight (Darea130) seems to be amore robust predictor for biomass estimates (lowest Akaike information criterion and relative squared error) than diameter measured above buttresses (DAB) or diameter at breast height estimated from available taper model. Finally, Darea130 might be estimated with a good precision [root mean square error (RMSE) < 5%] with linear model based on the field measurements DABand the perimeter of the convex hull of the buttresses at 1 3 mheight (Dconvhull130). 4. In this study, we showed the high potential of the photogrammetry for measuring and modelling irregular stems. Photogrammetry could then be used as a non-destructivemeasurement tool to produce correction factors for standardizing the diameter of irregular stems at a reference height which is a key issue in tree growthmonitoring and biomass change estimation. [less ▲]

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See detailUne cause atypique de fistule cutanée
Damiens, Justine; Shimizu, Naomi ULg; Claeys, Stéphanie ULg et al

in Monde Vétérinaire (Le) (2016), 163

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See detailIohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 1 : How to measure glomerular filtration rate with iohexol?
DELANAYE, Pierre ULg; Ebert, Natalie; Melsom, Toralf et al

in Clinical Kidney Journal (2016)

While there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose. As the gold ... [more ▼]

While there is general agreement on the necessity tomeasure glomerular filtration rate (GFR) inmany clinical situations, there is less agreement on the bestmethod to achieve this purpose. As the gold standardmethod for GFR determination, urinary (or renal) clearance of inulin, fades into the background due to inconvenience and high cost, a diversity of filtrationmarkers and protocols compete to replace it. In this review, we suggest that iohexol, a non-ionic contrast agent, is most suited to replace inulin as the marker of choice for GFR determination. Iohexol comes very close to fulfilling all requirements for an ideal GFRmarker in terms of low extra-renal excretion, low protein binding and in being neither secreted nor reabsorbed by the kidney. In addition, iohexol is virtually non-toxic and carries a low cost. As iohexol is stable in plasma, administration and sample analysis can be separated in both space and time, allowing access to GFR determination across different settings. An external proficiency programme operated by Equalis AB, Sweden, exists for iohexol, facilitating interlaboratory comparison of results. Plasma clearance measurement is the protocol of choice as it combines a reliable GFR determination with convenience for the patient. Single-sample protocols dominate, butmultiple-sample protocolsmay bemore accurate in specific situations. In lowGFRs one ormore late samples should be included to improve accuracy. In patients with large oedema or ascites, urinary clearance protocols should be employed. In conclusion, plasma clearance of iohexol may well be the best candidate for a common GFR determination method. [less ▲]

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See detailOrganizaciones regionales y diversidad cultural: la diplomacia de la Unión Europea con el Mercosur entre la sombra de Hollywood y la acción intergubernamental
Vlassis, Antonios ULg

in Cuadernos de Información y Comunicación (2016), 21

Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on ... [more ▼]

Abstract. The aim of the article is double: on the one hand, to explore the EU’s ability to conduct a foreign audiovisual policy towards the Mercosur region and to promote the norms of the Convention on diversity of cultural expressions; on the other hand, to analyze the impact of the EU audiovisual policy model on the development of the Mercosur audiovisual cooperation and to focus on the main forces shaping the Mercosur audiovisual landscape. The article seeks to emphasize why and how the EU pursues an audiovisual foreign policy towards the Mercosur region, for which purposes as well as to highlight the resistances. In this sense, it is more concerned with understanding how the EU’s audiovisual diplomacy interplays with other main factors, such as the governmental action, namely the EU and Mercosur members’ audiovisual diplomacy and the practices of private sector (Hollywood and big media conglomerates). [less ▲]

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See detailIohexol plasma clearance for measuring glomerular filtration rate in clinical practice and research: a review. Part 2: Why to measure glomerular filtration rate with iohexol?
DELANAYE, Pierre ULg; Melson, Toralf; Ebert, Natalie et al

in Clinical Kidney Journal (2016)

2 | P. Delanaye et al. Abstract A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is ... [more ▼]

2 | P. Delanaye et al. Abstract A reliable assessment of glomerular filtration rate (GFR) is of paramount importance in clinical practice as well as epidemiological and clinical research settings. It is recommended by Kidney Disease: Improving Global Outcomes guidelines in specific populations (anorectic, cirrhotic, obese, renal and non-renal transplant patients) where estimation equations are unreliable. Measured GFR is the only valuable test to confirm or confute the status of chronic kidney disease (CKD), to evaluate the slope of renal function decay over time, to assess the suitability of living kidney donors and for dosing of potentially toxic medication with a narrowtherapeutic index. Abnormally elevatedGFRor hyperfiltration in patients with diabetes or obesity can be correctly diagnosed only by measuring GFR. GFR measurement contributes to assessing the true CKD prevalence rate, avoiding discrepancies duetoGFRestimation with different equations. Usingmeasured GFR, successfullyaccomplished in large epidemiological studies, is the onlyway to study the potential link between decreased renal functionand cardiovascular or total mortality, being sure that this association is not due to confounders, i.e. non-GFR determinants of biomarkers. In clinical research, it has been shown that measured GFR (or measured GFR slope) as a secondary endpoint as compared with estimated GFR detected subtle treatment effects and obtained these results with a comparatively smaller sample size than trials choosing estimated GFR. Measuring GFR by iohexol has several advantages: simplicity, low cost, stability and low interlaboratory variation. Iohexol plasma clearance represents the best chance for implementing a standardized GFR measurement protocol applicable worldwide both in clinical practice and in research. [less ▲]

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See detailTransmission Efficiency of Cucumber Mosaic Virus by Myzus persicae According to Virus Strain and Aphid Clone from China
Bosquée, Emilie ULg; Yin, Ronling; Bragard, Claude et al

in Asian Journal of Plant Pathology (2016)

Background: Cucumber mosaic virus (CMV) is one of the most important viruses infecting vegetables in the fields throughout the world. Transmission efficiency of CMV could depend on the variability of ... [more ▼]

Background: Cucumber mosaic virus (CMV) is one of the most important viruses infecting vegetables in the fields throughout the world. Transmission efficiency of CMV could depend on the variability of virus strain but also aphid vector species and/or clones. Materials and Methods: By sequence analysis, the coat protein gene of CMV strains from different regions revealed that the CMV isolates used for this study belong to the same group. Both CMV strains and Myzus persicae (Sulzer) aphid clones were investigated for their role in viral dispersion by reciprocal tests on Nicotiana tabacum (L.) using the same clone of Myzus persicae towards different CMV strains or using one CMV strain on different Myzus persicae clones. Results: Virus transmission efficiency was found to be significantly influenced by selected CMV strains (from 5-30% of transmission rate for identical aphid clone) and also by the selected aphid clones (variation from 15-70% of transmission rate for identical virus strain). Conclusion: The CMV transmission efficiency depends on the variability of virus strain but also aphid vector clones. Combining the variability of CMV transmission rates for both aphid and virus sides, the prediction and modeling of virus spreading seems to be difficult to organize and are closely dependent on the variability of each protagonist-aphid and virus. [less ▲]

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See detailUsing a Jiles‐Atherton vector hysteresis model for isotropic magnetic materials with the finite element method, Newton‐Raphson method, and relaxation procedure
Guérin, Christophe; Jacques, Kevin ULg; Vazquez Sabariego, Ruth et al

in International Journal of Numerical Modelling: Electronic Networks, Devices and Fields (2016)

This paper deals with the use of a Jiles‐Ather ton vector hysteresis model included in 2D finite element modeling. The hysteresis model is only valid for isotropic materials. It is implemented with the ... [more ▼]

This paper deals with the use of a Jiles‐Ather ton vector hysteresis model included in 2D finite element modeling. The hysteresis model is only valid for isotropic materials. It is implemented with the vector potential formulation in 2D along with electric circuit equations to account for a possible external circuit. The Newton‐Raphson algorithm is used with a relaxation procedure, whereby at each iteration, th e relaxation coefficient is sought so as to minimize the Euclidean norm of the residual of the finite element nonlinear system of equations. We have simulated several numerical examples with the proposed approach. First, simulation s on a square domain were conducted so as to validate the model. We have further simulated a T‐shaped magnetic circuit (exhibiting rotating flux) and a 3‐phase 3‐limb transformer model. For these 2 cases, the eddy current losses in the laminations are taken into account by a low‐frequency model. We have finally performed simulations on the TEAM workshop problem 32, which consists of a 3‐limb transformer with 2 windings, for which current and local magnetic flux density measurements are available. We obtained a good agreement between computed and measured results. [less ▲]

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See detailPrimary Care Physicians’ Action Plans for Answering to Results of Screening Test based on the Concept of Quaternary Prevention
Bae, Jong Myon; Jamoulle, Marc ULg

in Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi (2016), 49(6), 343-348

Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician ... [more ▼]

Since non-communicable disease (NCD) should be controllable rather than curable, more emphasis is placed on prevention, rather than on treatment. For early detection of diseases, a primary care physician (PCP) as well as general practitioner and family physician should interpret screening results accurately and provide screenees with appropriate information of prevention and treatment including potential harms. The concept of quaternary prevention (QP), which was introduced by Jamoulle and Roland in 1995 was applied to screening results. This article summarizes situations that PCPs encounter during screening tests according to the concept of QP, and suggests measures to face such different situations. Suggestions for screening tests customized to the characteristics of individuals are substituting suggestions for screening based on guidelines. Since there are some circumstances that screening tests should not be done, further studies based on the concept of prevention level proposed by Jamoulle and Roland are required to draw various and useful prevention strategies to prevent NCDs, including cancers. Thus, applying the concept of QP helps PCPs have better insights on screening tests for preventing NCD and also contributes to improve doctor-patient relationship by helping screenees understand medical uncertainties. Key [less ▲]

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See detailQuantitative Three-Dimensional Color Flow Echocardiography of Chronic Mitral Regurgitation: New Methods, New Perspectives, New Challenges
zhou, x; vannan, m; LANCELLOTTI, Patrizio ULg

in Journal of the American Society of Echocardiography (2016), 29(10), 935-937

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See detailPhenology of farmed seaweed Kappaphycus alvarezii infestation by the parasitic epiphyte Polysiphonia sp. in Madagascar
Tsiresy, Gaëtan; Preux, Jérémy; Lavitra, Thierry et al

in Journal of Applied Phycology (2016), 28(5), 29032914

epiphytic filamentous algae (EFA) disease has appeared in many regions of Madagascar. This infestation has dramatic consequences for local farmers as it alters drastically farmed algal growth and has ... [more ▼]

epiphytic filamentous algae (EFA) disease has appeared in many regions of Madagascar. This infestation has dramatic consequences for local farmers as it alters drastically farmed algal growth and has caused farming activity to collapse in many places. The present study characterizes the structure and ultrastructure of the stages observed in the life cycle of Polysiphonia sp. and gives the results of a monitoring of 18 months made in three Kappaphycus alvarezii farming sites in the southwest of Madagascar. Transmission electron microscopy (TEM) was used to analyze the ultrastructure of the cortex in infested K. alvarezii. Five stages have been observed in the life cycle of Polysiphonia sp.: the infesting stage that is a small dark spot observed at the surface of K. alvarezii, the male gametophyte, the female gametophyte, the tetrasporocysts, and the undifferentiated stage where individuals show normal thalli without sexual differentiation. EFA infestation was never recorded in Sarodrano, but often in the two other monitored villages (Lambohara, Tampolove). Prevalence of infestation varied from 40 to 100 % and the rates of infestation from 42 to 78 epiphytes cm−2. Prevalence of infestation showed significant seasonal variation and a between-sites variation; the rates of infestation were not significantly different between sites and did not vary with the period. The ways of infestation between K. alvarezii individuals in an infested field and from infested to healthy fields are discussed at the light of the present results. [less ▲]

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See detailLes soins en hôpital de jour : du trou de serrure au jeu de clés…
REUTER, Benjamin ULg; TIBERGHIEN, Céline; Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2016), 18

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic ... [more ▼]

During a new period of disruption with the hospital-tradition of psychiatric care, the specificity and originality of the Day Hospital remains to be defined. The metaphoric dimension of the therapeutic “passe-partout”, could be appliqued to hospitals which are to this day, part of institutional therapy story: The care teams have effectively replaced the walls to accommodate the most complex mental diseases. Several therapeutic “keys” are well produced and co-constructed with the fundamental goal of allowing the patient to (re) gain freedom-bridges lost under the weight of his psychopathology. Even though in 40 years the Day Hospital continues to evolve and reinvent, it interestingly gets through crises. This ability to overcome crises is seen in the deinstitutionalization crisis where it was handled with stability due to its originality. Stability does not mean stagnation: the daily questioning of the therapeutic work group leads us… Thanks to this article, we will specifically highlight the therapeutic effect observed across the different support models to the Day Hospital. [less ▲]

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See detailLong-Term Results of 18 Fat Injections in Unilateral Vocal Fold Paralysis
PAGANO, Rémi ULg; Morsomme, Dominique ULg; CAMBY, Séverine ULg et al

in Journal of Voice (2016)

Summary: Objective. The purposes of this study were to assess the long-term efficacy of medialization laryngo- plasty via injection of autologous fat in patients with unilateral laryngeal paralysis, and ... [more ▼]

Summary: Objective. The purposes of this study were to assess the long-term efficacy of medialization laryngo- plasty via injection of autologous fat in patients with unilateral laryngeal paralysis, and to discuss the results based on the volume of fat injected and the size of the initial glottic gap. Study design. This was a retrospective study with clinical reevaluation of 18 patients treated for unilateral laryn- geal paralysis at Liège University Hospital between April 1, 2011, and December 1, 2014. Method. The voice examination included subjective scales (GRBAS and the Voice Handicap Index), a report on acous- tic and aerodynamic voice parameters, and laryngostroboscopic assessment of glottic closure and mucosal wave (T0: preoperative; T1: immediate postoperative; T2: >1 year). Results. The median follow-up duration was 19 months. We observed a significant improvement in maximum pho- nation time; mean flow rate; jitter; the Voice Handicap Index; the G, R, B, and A subscales of the GRBAS-I; and glottic closure at T1. These parameters remained stable over time, without any significant difference except for shimmer and glottic closure between T1 and T2. Regardless of the volume of fat injected and the magnitude of the initial glottic gap, we did not see any significant difference from one assessment time to another. Conclusion. Medialization laryngoplasty by means of the injection of autologous fat is a safe, effective surgical tech- nique for patients with unilateral laryngeal paralysis regardless of the size of the initial glottic gap. The results are maintained longer than 1 year, and no evidence of significant resorption of the fat was found in our study over a period of 12–58 months. The volume of fat injected does not seem to affect the functional results. Key Words: Glottic insufficiency–Glottic closure–Glottic gap–Laryngeal paralysis–Vocal fold paralysis–Laryngoplasty– Autologous fat–Fat injection. [less ▲]

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See detailL’approche sémiotique de Charles Goodwin : langage visuel, énonciation et diagramme
Dondero, Maria Giulia ULg

in Tracés. Revue de Sciences Humaines (2016), 3(automne),

This text investigates the connexion between the work of Charles Goodwin and contemporary semiotics. I initially address the relations between verbal, visual, and gestural languages in semiotic terms by ... [more ▼]

This text investigates the connexion between the work of Charles Goodwin and contemporary semiotics. I initially address the relations between verbal, visual, and gestural languages in semiotic terms by exploring the Goodwin’s notational system (transcription of exchanges) from the point of view of its constituent units. Secondly, I consider the meeting points between Goodwin’s concept of the substrate and Fontanille’s enunciative praxis in order to examine the dynamic relationship between sedimentation and transformation. Finally, I analyse the concept of diagrammatic reasoning by elaborating on the example of the geologists’ “first inscriptions” studied by Goodwin. The form of diagrammatic reasoning examined here functions as a discovery device that exemplifies the dynamics of sedimentation and novelty, and it can thus be studied in the framework of Goodwin’s transcription practices. [less ▲]

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See detailLE MÉDICAMENT DU MOIS Dapagliflozine (Forxiga®) Inhibiteur des cotransporteurs rénaux SGLT2, nouvel agent anti-hyperglycémiant dans le diabète de type 2
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71(10), 463-469

Résumé : La dapagliflozine, un inhibiteur spécifique des cotransporteurs sodium-glucose de type 2 (SGLT2), inhibe la réabsorption tubulaire rénale du glucose et accroît la gluco¬surie. Il en résulte une ... [more ▼]

Résumé : La dapagliflozine, un inhibiteur spécifique des cotransporteurs sodium-glucose de type 2 (SGLT2), inhibe la réabsorption tubulaire rénale du glucose et accroît la gluco¬surie. Il en résulte une diminution de la glycémie et du taux d’hémoglobine glyquée (HbA1c), avec un risque faible d’hypo¬glycémie, une perte pondérale et une diminution de la pression artérielle. L’efficacité sur la réduction du taux d’HbA1c est d’autant plus importante que l’hyperglycémie est élevée, mais elle diminue en cas d’insuffisance rénale. Les infections géni¬tales mycotiques sont plus fréquentes, surtout chez la femme, alors que l’augmentation des infections urinaires basses n’est que marginale. La dapagliflozine (Forxiga®), commercialisée à la dose de 10 mg une fois par jour, est indiquée pour le trai¬tement du diabète de type 2 et remboursée en Belgique, sous conditions, en ajout à la metformine, un sulfamide ou le répa-glinide, une association metformine-sulfamide/répaglinide ou une insuline basale avec au moins un antidiabétique oral. Des données préliminaires ne démontrent pas d’augmentation du risque cardiovasculaire par rapport au comparateur et suggèrent même une protection cardiovasculaire et rénale, à confirmer dans l’essai DECLARE, une grande étude prospec¬tive contrôlée actuellement en cours chez des patients diabé¬tiques de type 2 à haut risque cardiovasculaire. [less ▲]

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See detailA case of added value of 123I-mIBG SPECT/CT imaging in the diagnosis of a pheochromocytoma extending into the left adrenal vein
PAQUES, Florence ULg; HAMOIR, Etienne ULg; LOVINFOSSE, Pierre ULg et al

in Acta Chirurgica Belgica (2016)

We present the case of a 48-year-old patient with a left adrenal incidentaloma found on computed tomography (CT) for which the diagnosis of pheochromocytoma was confirmed by a 24-hour urinary dosage of ... [more ▼]

We present the case of a 48-year-old patient with a left adrenal incidentaloma found on computed tomography (CT) for which the diagnosis of pheochromocytoma was confirmed by a 24-hour urinary dosage of norepinephrine. The 123I-mIBG scintigraphy showed a high uptake of 123I-mIBG in the left adrenal gland and, additionally, the single photon emission computed tomography combined with a low-dose CT (SPECT/CT) suggested the extension into the adrenal vein. The diagnostic CT and magnetic resonance images agreed with these findings and the subsequent surgery confirmed the vascular invasion. [less ▲]

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See detailELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer
Delaunay, Sylvain ULg; Rapino, Francesca ULg; Tharun, Lars et al

in The Journal of Experimental Medicine (2016), 213

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Post-transcriptional nucleoside modifications of transfer RNAs (tRNAs) at the ... [more ▼]

Quantitative and qualitative changes in mRNA translation occur in tumor cells and support cancer progression and metastasis. Post-transcriptional nucleoside modifications of transfer RNAs (tRNAs) at the wobble U34 base are highly conserved and contribute to translation fidelity. Here, we show that ELP3 and CTU1/2, partner enzymes in U34 mcm5s2-tRNA modification, are upregulated in human breast cancers and sustain metastasis. Elp3 genetic ablation strongly impaired invasion and metastasis formation in the PyMT model of invasive breast cancer. Mechanistically, ELP3 and CTU1/2 support cellular invasion through the translation of the oncoprotein DEK. As a result, DEK promotes the IRES-dependent translation of the pro-invasive transcription factor LEF1. Consistently, a DEK mutant, whose codon composition is independent of U34 mcm5s2-tRNA modification, escapes the ELP3- and CTU1-dependent regulation and restores the IRES-dependent LEF1 expression. Our results demonstrate the key role of U34 tRNA modification to support specific translation during breast cancer progression and highlight a functional link between tRNA modification- and IRES-dependent translation during tumor cell invasion and metastasis. [less ▲]

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See detailTransnational Ageing and the ‘Zero Generation’: The Role of Moroccan Migrants’ Parents in Care Circulation
Zickgraf, Caroline ULg

in Journal of Ethnic and Migration Studies (2016)

This article emphasizes the impacts of international migration on ageing processes and norms within transnational families, and, specifically, analyses the roles of the zero generation, defined as the ... [more ▼]

This article emphasizes the impacts of international migration on ageing processes and norms within transnational families, and, specifically, analyses the roles of the zero generation, defined as the parents of first-generation migrants (Nedelcu 2009), both as non-migrant counterparts to their children abroad and as ageing migrants themselves. Transnational caregiving research has demonstrated that for many migrants and their families care arrangements must be negotiated across national borders, yet the agency of transnational older adults has been largely neglected. Based on qualitative fieldwork conducted from 2011 to 2013 in Liège, Belgium and Oujda, Morocco, the present article examines the circulation of care between Moroccan adult migrants and their ageing ascendants. This article exposes the duality of migrants’ ascendants as care givers and recipients, asserting firstly, that receiving care is not synonymous with passivity, and that, secondly, migrants’ ascendants are also the initiators of transnational practices. In both roles, this article underlines mobility as a strategy used by migrants’ parents to maintain family solidarity across national borders, but that this care mobility is limited by macro-level migration policies, here exemplified by the Belgian migration regime. [less ▲]

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See detailApparition de la puberté chez les agneaux mâles de race Ouled Djellal
Boussena, Sabrina; Bouaziz, O.; Hireche, S. et al

in Revue de Médecine Vétérinaire (2016), 167(9-10), 274-282

The aim of this study is to evaluate the body and testicular growth performances in Ouled Djellal rams from weaning until twelve months of age. It also contributes to the study of the onset of puberty in ... [more ▼]

The aim of this study is to evaluate the body and testicular growth performances in Ouled Djellal rams from weaning until twelve months of age. It also contributes to the study of the onset of puberty in Ouled Djellal rams and to follow the subsequent evolution of their semen production. Weekly measurements of body weight, chest perimeter, scrotal circumference, testicular length and diameter, as well as the cauda-epididymis diameter of the gonads were conducted in ten rams, from weaning and until the onset of puberty. Semen collection was also performed in the same manner with an electroejaculator in order to define puberty. After the onset of puberty, observations were made fortnightly on body weight, chest perimeter, testis morphometry and the evolution of semen characteristics. Puberty settled at an average age of 228± 7 days with an average weight of 40.4 ± 1.2 kg. Highly significant correlations were observed between testicular measurements and those of the body. Similar significant correlations were also observed between testicular measurements (especially scrotal circumference) and semen characteristics after puberty. [less ▲]

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See detailUne approche psychocriminologique de la radicalisation : le modèle de «transformation cognitivo-affective de la définition de soi et de la construction du sens dans l’engagement radical violent»
Garcet, Serge ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 3

La question de la radicalisation violente renvoie à un champ de recherches transdisciplinaire qui nécessite d’articuler les niveaux micro, méso et macro d’analyse. Dans cette perspective, après avoir ... [more ▼]

La question de la radicalisation violente renvoie à un champ de recherches transdisciplinaire qui nécessite d’articuler les niveaux micro, méso et macro d’analyse. Dans cette perspective, après avoir interrogé la place faite aux variables individuelles dans les principaux modèles explicatifs du processus de radicalisation, l’article envisage comment la capacité d’autodétermination du sujet et sa capacité à agir sur lui-même autant que sur son environnement transforment progressivement les cognitions et nourrissent la motivation à s’engager. Les principes de cette interaction complexe entre la personne et son environnement sont synthétisés dans le modèle original de «transformation cognitivo-affective de la définition de soi et de la construction du sens dans l’engagement radical violent ». [less ▲]

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See detailEntreprise sociale et économie sociale en Asie (Partie II)
Bidet, Eric; Defourny, Jacques ULg; Nyssens, Marthe (eds)

in Revue Internationale de l'Economie Sociale : Recma, Revue des Etudes Coopératives, Mutualistes et Associatives (2016), (n° 342),

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See detailCo-simulation of Electromagnetic Transients and Phasor Models: a Relaxation Approach
Plumier, Frédéric ULg; Aristidou, Petros; Geuzaine, Christophe ULg et al

in IEEE Transactions on Power Delivery (2016), 31(5),

Co-simulation opens new opportunities to combine mature ElectroMagnetic Transients (EMT) and Phasor-Mode (PM) solvers, and take advantage of their respective high accuracy and execution speed. In this ... [more ▼]

Co-simulation opens new opportunities to combine mature ElectroMagnetic Transients (EMT) and Phasor-Mode (PM) solvers, and take advantage of their respective high accuracy and execution speed. In this paper, a relaxation approach is presented, iterating between an EMT and a PM solver. This entails interpolating over time the phasors of the PM simulation, extracting phasors from the time evolutions of the EMT simulation, and representing each sub-system by a proper multiport equivalent when simulating the other sub-system. Various equivalents are reviewed and compared in terms of convergence of the PM-EMT iterations. The paper also considers the update with frequency of the Thévenin impedances involved in the EMT simulation, the possibility to compute the EMT solution only once per time step, and the acceleration of convergence through a prediction over time of the boundary variables. Results are presented on a 74-bus, 23-machine test system, split into one EMT and one PM sub-system with several interface buses. [less ▲]

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See detailDon et dette de vie à l'adolescence
Haxhe, Stéphanie ULg; de Saint Georges, Marie-Christine; Michard, Pierre et al

in Adolescence (2016), 34(3), 597-605

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît ... [more ▼]

L’adolescent récuse la dette de vie et réclame autonomie et considération. Néanmoins, la société actuelle offre à l’adolescent des parents fragilisés. La réalité de l’adolescent contemporain apparaît alors comme une quête en tension entre une nécessaire appropriation de lui-même et des dons discrets à ses parents. Si ces dons ne sont pas reçus et échouent à introduire parents et adolescent à une nouvelle position relationnelle, le risque d’un épuisement de l’adolescent est à prendre en considération. [less ▲]

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See detailLe bouleau, une essence qui s'impose. Description de la ressource dans son aire de distribution
Dubois, Héloïse ULg; Latte, Nicolas ULg; Lecomte, Hugues et al

in FORÊT.NATURE (2016), 140

L'essentiel de la ressource en bouleau (verruqueux et pubescent) se situe en Russie et en Scandinavie (15 milliards de m³) et cette ressource augmente graduellement depuis plusieurs années. Il y est ... [more ▼]

L'essentiel de la ressource en bouleau (verruqueux et pubescent) se situe en Russie et en Scandinavie (15 milliards de m³) et cette ressource augmente graduellement depuis plusieurs années. Il y est fortement valorisé en sciage, déroulage et trituration. En Europe de l'Ouest, cette croissance s'observe aussi, même si seulement 1 % de la ressource s'y concentre (dû notamment à la plus grande diversité d'essences commerciales présentes). En Wallonie, les évolutions du contexte socio-économique et environnemental jouent en faveur d'une augmentation de la présence du bouleau (parcelles non reboisées, entretien insuffisant, mélanges spontanés...). Le bouleau représente souvent une belle opportunité pour les mélanges, une excellente essence d'accompagnement et une diversification de la production. Mais, sans une sylviculture adaptée, les grumes sont généralement de faible dimension et présentent de nombreux défauts. C'est le cas de l'essentiel de la ressource actuelle en Wallonie. Aujourd'hui, les besoins sont de mieux le connaître, notamment les opportunités de valorisation, et d'aboutir à des recommandations sylvicoles. Il ne s'agit donc pas de vouloir faire du bouleau à tout prix mais plutôt de tirer profit d'une étape transitoire de la succession forestière. [less ▲]

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See detailInternational Trade Sanctions related to Dual-Use Goods and Technologies
Colussi, Ilaria Anna ULg

in Athens Journal of Law (2016), 2(4), 237-252

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may ... [more ▼]

One of the basic rules in trade law is the freedom of trade. However, such rule encounters some limitations when the object of trade is constituted by strategic items, such as dual-use items, which may have peaceful (civilian/commercial) or non peaceful/military applications. Trade of these categories of goods needs to be controlled, as they can provoke security concerns. Such control is pursued through control lists, licenses, authorizations to stakeholders of the supply chain, information- sharing and cooperation mechanisms, reports, records, declarations, screenings and sanctions as well. The paper aims at focusing on the issue of sanctions, in particular the ones established at the international level: these measures are provided for the violation of trade rules in reference to dual-use items, and/or sanctions have as an object this type of goods. The legal provisions established by the World Trade Organization (WTO) and at the United Nations level are analysed thereafter. Brief observations are offered as regards the EU framework of restrictive measures too. [less ▲]

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See detailL’évaluation de la formation : comment la rendre utile pour les participants ? Constats et proposition de cinq stratégies d’évaluation partenariale
Faulx, Daniel ULg; Danse, Cédric ULg

in Evaluer : Journal International de Recherche en Education et Formation (2016), 2(1), 37-52

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente ... [more ▼]

L’évaluation de la formation par les participants est une pratique courante aujourd’hui, portée à la fois par des exigences de rentabilité et de qualité. Cependant, cet exercice, qui se présente souvent sous la forme de questionnaires individuels remis à la fin de la formation, peut être vécu par ceux qui les remplissent comme un rituel obligé mais présentant peu d’intérêt. C’est dans l’intention de proposer une alternative à cette situation que cet article a été rédigé. Dans un premier temps, nous faisons le point sur les modes les plus habituels d’évaluation de la formation par les participants. Nous identifions les récurrences de ce genre de pratique et les questions qu’elles posent. Ensuite, nous avançons cinq manières de procéder à une évaluation de telle sorte qu’elle soit bénéfique tant aux apprenants qu’au formateur. Les propositions sont réparties en deux familles (centrée sur l’activité de l’apprenant et centrée sur le processus de formation). Elles visent, au contraire de ce qui est pratiqué habituellement, à mettre au travail chacun des acteurs, formateur comme apprenants, afin que le moment de l’évaluation constitue une occasion de continuer à apprendre. Cette approche est aussi potentiellement transférable en contexte scolaire lors de l’évaluation des enseignants (ou des enseignements) par les élèves/étudiants. [less ▲]

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See detailLa revue Poétique
Lorent, Fanny ULg

in La revue des revues (2016), 56

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Peer Reviewed
See detailShift in the chemical composition of dissolved organic matter in the Congo River network
Lambert, Thibault ULg; Bouillon, S.; Darchambeau, François ULg et al

in Biogeosciences (2016), 13(18), 5405-5420

The processing of terrestrially derived dissolved organic matter (DOM) during downstream transport in fluvial networks is poorly understood. Here, we report a dataset of dissolved organic carbon (DOC ... [more ▼]

The processing of terrestrially derived dissolved organic matter (DOM) during downstream transport in fluvial networks is poorly understood. Here, we report a dataset of dissolved organic carbon (DOC) concentrations and DOM composition (stable carbon isotope ratios, absorption and fluorescence properties) acquired along a 1700 km transect in the middle reach of the Congo River Basin. Samples were collected in the mainstem and its tributaries during high water (HW) and falling water (FW) periods. DOC concentrations and DOM composition along the mainstem were found to differ between the two periods, because of a reduced lateral mixing between the central water masses of the Congo River and DOM-rich waters from tributaries and also likely because of a greater photodegradation during FW as water residence time (WRT) increased. Although the Cuvette Centrale wetland (one of the world’s largest flooded forest) continuously releases highly aromatic DOM in streams and rivers of the Congo Basin, the downstream transport of DOM was found to result in an along stream gradient from aromatic to aliphatic compounds. The characterization of DOM through parallel factor analysis (PARAFAC) suggests that this transition results from (1) the losses of aromatic compounds by photodegradation and (2) the production of aliphatic compounds by biological reworking of terrestrial DOM. Finally, this study highlights the critical importance of the river-floodplain connectivity in tropical rivers in controlling DOM biogeochemistry at large spatial scale and suggests that the degree of DOM processing during downstream transport is a function of landscape characteristics and WRT [less ▲]

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