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See detailUse of dual carbon-chlorine isotope analysis to assess the degradation pathways of 1,1,1-trichloroethane in groundwater
Palau, Jordi; Jamin, Pierre ULg; Badin, Alice et al

in Water Research (2016)

Compound-specific isotope analysis (CSIA) is a powerful tool to track contaminant fate in groundwater. However, the application of CSIA to chlorinated ethanes has received little attention so far. These ... [more ▼]

Compound-specific isotope analysis (CSIA) is a powerful tool to track contaminant fate in groundwater. However, the application of CSIA to chlorinated ethanes has received little attention so far. These compounds are toxic and prevalent groundwater contaminants of environmental concern. The high susceptibility of chlorinated ethanes like 1,1,1-trichloroethane (1,1,1-TCA) to be transformed via different competing pathways (biotic and abiotic) complicates the assessment of their fate in the subsurface. In this study, the use of a dual C-Cl isotope approach to identify the active degradation pathways of 1,1,1-TCA is evaluated for the first time in an aerobic aquifer impacted by 1,1,1-TCA and trichloroethylene (TCE) with concentrations of up to 20 mg/L and 3.4 mg/L, respectively. The reaction-specific dual carbon-chlorine (C-Cl) isotope trends determined in a recent laboratory study illustrated the potential of a dual isotope approach to identify contaminant degradation pathways of 1,1,1-TCA. Compared to the dual isotope slopes (Δδ13C/Δδ37Cl) previously determined in the laboratory for dehydrohalogenation / hydrolysis (DH/HY, 0.33 ± 0.04) and oxidation by persulfate (∞), the slope determined from field samples (0.6 ± 0.2, r2 = 0.75) is closer to the one observed for DH/HY, pointing to DH/HY as the predominant degradation pathway of 1,1,1-TCA in the aquifer. The observed deviation could be explained by a minor contribution of additional degradation processes. This result, along with the little degradation of TCE determined from isotope measurements, confirmed that 1,1,1-TCA is the main source of the 1,1-dichlorethylene (1,1-DCE) detected in the aquifer with concentrations of up to 10 mg/L. This study demonstrates that a dual C-Cl isotope approach can strongly improve the qualitative and quantitative assessment of 1,1,1-TCA degradation processes in the field. [less ▲]

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See detailA 3-year long study of Staphylococcus aureus isolates from subclinical mastitis in three Azawak zebu herds at the Sahelian experimental farm of Toukounous, Niger
Issa Ibrahim, Abdoulkarim; Duprez, Jean-Noël ULg; Bada-alambdeji, Rianatou et al

in Tropical Animal Health and Production (2016), 48(2), 321-329

bovine mastitis. The aim of the present work was to follow in three herds and during the 3 years the clonality of S. aureus isolated from California Mastitis Test (CMT)-positive cows at the experimental ... [more ▼]

bovine mastitis. The aim of the present work was to follow in three herds and during the 3 years the clonality of S. aureus isolated from California Mastitis Test (CMT)-positive cows at the experimental station of Toukounous (Niger) by (i) comparing their pulsed field gel electrophoresis (PFGE) fingerprints, (ii) identifying their virulotypes by PCR amplification and (iii) assessing the production of capsule and the formation of biofilm. The 88 S. aureus isolates belonged to 14 different pulsotypes, 3 of them being predominant: A (30 %), D (27 %), B (15 %). A and B pulsotypes had the highest profile similarity coefficient (94 %), while others had similarity coefficients under 60 %. Seventy-five S. aureus isolates were further studied for their virulotypes, capsular antigens and biofilm production. Most surface factor-, leukocidin- and haemolysin-, but not the enterotoxin-encoding genes were detected in the majority (>75 %) of the isolates and were evenly distributed between the A, B and D pulsotype isolates. The majority of the 72 S. aureus positive with the cap5H or cap8H PCR produced the CP5 (82 %) or the CP8 (88 %) capsular antigen, respectively. Biofilm production by the 57 icaA-positive isolates was strong for 8 isolates, moderate for 31 isolates but weak for 18 isolates, implying that the icaA gene may not be expressed in vitro by one third of the positive isolates. Similar to other studies, those results confirm that a restricted number of S. aureus clones circulate within the three herds at Toukounous and that their specific virulence-associated properties must still be further studied [less ▲]

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See detailAnalysis of the Structure and Function of FOX-4 Cephamycinase
Lefurgy, S.T.; Malashkevich, V.N.; Aguilan, J.T. et al

in Antimicrobial Agents and Chemotherapy (2016), 60(2), 717-728

Class C β-lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC β-lactamases conferring resistance to cefoxitin ... [more ▼]

Class C β-lactamases poorly hydrolyze cephamycins (e.g., cefoxitin, cefotetan, and moxalactam). In the past 2 decades, a new family of plasmid-based AmpC β-lactamases conferring resistance to cefoxitin, the FOX family, has grown to include nine unique members descended from the Aeromonas caviae chromosomal AmpC. To understand the basis for the unique cephamycinase activity in the FOX family, we determined the first X-ray crystal structures of FOX-4, apo enzyme and the acyl-enzyme with its namesake compound, cefoxitin, using the Y150F deacylation-deficient variant. Notably, recombinant expression of N-terminally tagged FOX-4 also yielded an inactive adenylylated enzyme form not previously observed in β-lactamases. The posttranslational modification (PTM), which occurs on the active site Ser64, would not seem to provide a selective advantage, yet might present an opportunity for the design of novel antibacterial drugs. Substantial ligand-induced changes in the enzyme are seen in the acyl-enzyme complex, particularly the R2 loop and helix H10 (P289 to N297), with movement of F293 by 10.3 Å. Taken together, this study provides the first picture of this highly proficient class C cephamycinase, uncovers a novel PTM, and suggests a possible cephamycin resistance mechanism involving repositioning of the substrate due to the presence of S153P, N289P, and N346I substitutions in the ligand binding pocket. [less ▲]

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See detailNumerical modeling of the long term behavior of Municipal Solid Waste in a bioreactor landfill
Hubert, Julien ULg; Xianfeng, Liu; Collin, Frédéric ULg

in Computers and Geotechnics (2016), 72

This paper presents a thermo-hydro–biochemo-mechanical model for simulating the long term behavior of Municipal Solid Waste (MSW) in a bioreactor landfill, in which the multi-physics coupling mechanism ... [more ▼]

This paper presents a thermo-hydro–biochemo-mechanical model for simulating the long term behavior of Municipal Solid Waste (MSW) in a bioreactor landfill, in which the multi-physics coupling mechanism plays a dominant role. In the model, a two-stage anaerobic biochemical model based on McDougall’s formulation is incorporated into a fully coupled thermo-hydro-mechanical models originally developed for unsaturated porous medium. The mechanical model is a modified Camclay model allowing for biochemical hardening/softening, while the thermal model is described by a classical energy balance equation with a source term accounting for the heat generation from the biodegradation of organic matter. The hydraulic model is an unsaturated flow model using Richard’s equation. The derived coupled model is implemented into an in-house built multi-physics finite element code. Finally, numerical simulations were performed to illustrate the capability of the proposed model for estimating long-term settlement of a bioreactor landfill and its aptitude as a landfill management tool for optimizing the landfill operation [less ▲]

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See detailDoes biobased polymer achieve better environmental impacts than fossil polymer? Comparison of fossil HDPE and biobased HDPE produced from sugar beet and wheat
Belboom, Sandra ULg; Léonard, Angélique ULg

in Biomass & Bioenergy (2016), 85

Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed ... [more ▼]

Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed, the transformation of biobased ethanol into biobased polymer being one of them. This paper undertakes an environmental evaluation of the production of biobased polymer produced from two different feedstock cultivated in Belgium: sugar beet and wheat. Both crops cultivation are studied as well as their transformation into biobased ethanol, first, and then to biobased ethylene, focusing on high-density polyethylene (HDPE) as final product. These scenarios are analyzed and compared with the production of conventional polymer using the life-cycle assessment (LCA) methodology with reference to relevant environmental impact categories. This study shows a reduction of impact of around 60% for both climate change and fossil fuel depletion categories when using biobased HDPE instead of its fossil counterpart. For all other impact categories, fossil HDPE achieves better results than the biobased product. [less ▲]

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See detailDynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors
Stankovic, Nancy ULg; Schloesser, Marie ULg; Joris, Marine ULg et al

in Plant Physiology (2016), 170

Serine/Arginine-rich (SR) proteins are essential nucleus-localized splicing factors. Our prior studies showed that Arabidopsis RSZ22, a homolog of the human SRSF7 SR factor, exits the nucleus through two ... [more ▼]

Serine/Arginine-rich (SR) proteins are essential nucleus-localized splicing factors. Our prior studies showed that Arabidopsis RSZ22, a homolog of the human SRSF7 SR factor, exits the nucleus through two pathways, either dependent or independent on the XPO1 receptor. Here, we examined the expression profiles and shuttling dynamics of the Arabidopsis SRSF1 subfamily (SR30, SR34, SR34a and SR34b) under control of their endogenous promoter in Arabidopsis and in transient expression assay. Due to its rapid nucleocytoplasmic shuttling and high expression level in transient assay, we analysed the multiple determinants that regulate the localisation and shuttling dynamics of SR34. By site-directed mutagenesis of SR34 RNA-binding sequences and RS domain, we further show that functional RRM1 or RRM2 are dispensable for the exclusive protein nuclear localization and speckle-like distribution. However, mutations of both RRMs induced aggregation of the protein whereas mutation in the RS domain decreased the stability of the protein and suppressed its nuclear accumulation. Furthermore, the RNA-binding motif mutants are defective for their export through the XPO1 (CRM1/Exportin-1) receptor pathway, but retain nucleocytoplasmic mobility. We performed a yeast two hybrid screen with SR34 as bait and discovered SR45 as a new interactor. SR45 is an unusual SR splicing factor bearing two RS domains. These interactions were confirmed in planta by FLIM-FRET and BiFC and the roles of SR34 domains in protein-protein interactions were further studied. Altogether, our report extends our understanding of shuttling dynamics of Arabidopsis SR splicing factors [less ▲]

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See detailSimultaneous production of acetic and gluconic acids by a thermotolerant Acetobacter strain during acetous fermentation in a bioreactor
Mounir, Majid ULg; shafiei, rasoul; Zarmehrkhorshid, Raziyeh et al

in Journal of Bioscience & Bioengineering (2016), 121(2), 166-171

The activity of bacterial strains significantly influences the quality and the taste of vinegar. Previous studies of acetic acid bacteria have primarily focused on the ability of bacterial strains to ... [more ▼]

The activity of bacterial strains significantly influences the quality and the taste of vinegar. Previous studies of acetic acid bacteria have primarily focused on the ability of bacterial strains to produce high amounts of acetic acid. However, few studies have examined the production of gluconic acid during acetous fermentation at high temperatures. The production of vinegar at high temperatures by two strains of acetic acid bacteria isolated from apple and cactus fruits, namely AF01 and CV01, respectively, was evaluated in this study. The simultaneous production of gluconic and acetic acids was also examined in this study. Biochemical and molecular identification based on a 16s rDNA sequence analysis confirmed that these strains can be classified as Acetobacter pasteurianus. To assess the ability of the isolated strains to grow and produce acetic acid and gluconic acid at high temperatures, a semi-continuous fermentation was performed in a 20-L bioreactor. The two strains abundantly grew at a high temperature (41°C). At the end of the fermentation, the AF01 and CV01 strains yielded acetic acid concentrations of 7.64% (w/v) and 10.08% (w/v), respectively. Interestingly, CV01 was able to simultaneously produce acetic and gluconic acids during acetic fermentation, whereas AF01 mainly produced acetic acid. In addition, CV01 was less sensitive to ethanol depletion during semi-continuous fermentation. Finally, the enzymatic study showed that the two strains exhibited high ADH and ALDH enzyme activity at 38°C compared with the mesophilic reference strain LMG 1632, which was significantly susceptible to thermal inactivation. [less ▲]

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See detailLe livre au futur antérieur. Les ambiguïtés d’un motif d’anticipation
Stienon, Valérie ULg; Barel-Moisan, Claire

in Autour de Vallès : Revue de Lectures et d'Etudes Vallésiennes (2016), 45(2015), 147-168

Du tournant du XIXe siècle aux années 1940, le récit d’anticipation est enclin à articuler un imaginaire social et des extrapolations du présent qui le portent à considérer, parmi d’autres aspects ... [more ▼]

Du tournant du XIXe siècle aux années 1940, le récit d’anticipation est enclin à articuler un imaginaire social et des extrapolations du présent qui le portent à considérer, parmi d’autres aspects socioculturels, la situation de la littérature et de ce qu’on peut nommer le modèle culturel « lettré », avec son histoire, ses valeurs, ses acteurs et ses institutions. Sur ce point, on peut observer à la fois la perméabilité des fictions conjecturales aux discours et représentations liés à leur premier contexte, et les modulations originales qu’elles y apportent. [less ▲]

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See detailLe médicament du mois. Insuline glargine 300 U/mL (Toujeo®)
SCHEEN, André ULg

in Revue Médicale de Liège (2016), 71

Summary : This article presents a new formulation of insulin glargine concentrated at 300 U/mL (Gla-300). It is commercialized under the trade name of Toujeo® in an optimized pre-filled SoloStar™ pen for ... [more ▼]

Summary : This article presents a new formulation of insulin glargine concentrated at 300 U/mL (Gla-300). It is commercialized under the trade name of Toujeo® in an optimized pre-filled SoloStar™ pen for the treatment of type 1 and type 2 diabetes in adults. Besides a threefold higher concentration compared to the classical insulin Lantus® (100 U/mL or Gla-100), both pharmacokinetic and pharmacodynamic profiles of Gla-300 are flatter and longer (more than 24 hours) and have a lesser intra-/inter-variability, which makes them more reproducible. Overall, Toujeo® offers the same hypoglycaemic efficacy and the same safety profile when compared with Lantus®. However, a lower risk of hypoglycaemia, especially at night, a slightly smaller weight gain and a better flexibility in the time of injection have been reported. The two insulin formulations are not bioequivalent and the daily insulin requirement is slightly higher with insulin Gla-300 than with insulin Gla-100. The shift from an already available basal insulin towards Toujeo® may require a dose adjustment and a reinforcement of blood glucose monitoring. [less ▲]

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See detailSubstituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
Marquise, Nada; Chevallier, Floris; Nassar, Ekhlas et al

in Tetrahedron (2016), 72(6), 825-836

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions ... [more ▼]

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties [less ▲]

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See detailHyaluronic acid and tendon lesions
Kaux, Jean-François ULg; SAMSON, Antoine; Crielaard, Jean-Michel ULg

in Muscles, Ligaments and Tendons Journal (2016), 5(4 (eCollection 2015 Oct-Dec)), 264-269

Introduction: Recently, the viscoelastic properties of hyaluronic acid on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results ... [more ▼]

Introduction: Recently, the viscoelastic properties of hyaluronic acid on liquid connective tissue have been proposed for the treatment of tendinopathies. Some fundamental studies show encouraging results on hyaluronic acid’s ability to promote tendon gliding and reduce adhesion as well as to improve tendon architectural organisation. Some observations also support its use in a clinical setting to improve pain and function. This literature review analyses studies relating to the use of hyaluronic acid in the treatment of tendinopathies. Methods: This review was constructed using the Medline database via Pubmed, Scopus and Google Scholar. The keywords hyaluronic acid, tendon and tendinopathy were used for the research. Results: In total, 27 articles (in English and French) on the application of hyaluronic acid to tendons were selected for their relevance and scientific quality, including eight for the 'in vitro' part, three for the 'in vivo' animal part and six for the human section. Conclusions: Preclinical studies demonstrate encouraging results: HA permits tendon gliding, reduces adhesions, creates better tendon architectural organisation and limits inflammation. These laboratory observations appear to be supported by limited but encouraging short-term clinical results on pain and function. However, controlled randomised studies are still needed. [less ▲]

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See detailIs Darwin's 'Abominable Mystery' still a mystery today?
Cascales-Miñana, Borja ULg; Cleal, Chris J.; Gerrienne, Philippe ULg

in Cretaceous Research (2016), 61

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See detailDiacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO
Pavelka, Karel; Bruyère, Olivier ULg; Cooper, Cyrus et al

in Drugs & Aging (2016), 33(2), 75-85

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been ... [more ▼]

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit–risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated [less ▲]

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See detailConséquences génétiques et morphologiques des glaciations du Quaternaire : une lignée relique du barbeau (Luciobarbus pallaryi, Cyprinidae) dans le bassin du Guir (Algerie)
Brahimi, Amina; Tarai, Nacer; Benhassane, Abdelkrim et al

in Comptes Rendus Biologies (2016), 339

Climatic variations during the Quaternary period had a considerable impact on landscapes and habitat fragmentation (rivers) in North Africa. These historical events can have significant consequences on ... [more ▼]

Climatic variations during the Quaternary period had a considerable impact on landscapes and habitat fragmentation (rivers) in North Africa. These historical events can have significant consequences on the genetic structure of the populations. Indeed, geographi- cally separated and genetically isolated populations tend to differentiate themselves through time, eventually becoming distinct lineages, allowing new species to emerge in later generations. The aim of the present study is to use genetic and morphological techniques to evaluate the major role of the Saalian glaciation (Middle Quaternary) in the establishment of the geographic space and in the evolution of the intraspecific genetic diversity, by tracing the demographic history of barbels belonging to the Luciobarbus pallaryi (Cyprinidae) species in the Guir Basin (Algeria). In this context, two populations, from two distinct and isolated sites, were studied. Analysis of the cytochrome b (cyt b) mitochondrial markers and of the ‘‘D-loop’’ control region has shown that the ‘‘upstream’’ and ‘‘downstream’’ Guir populations are genetically differentiated. The molecular analyses suggest that the upstream population was disconnected from this hydrographic system during the Saalian glaciation period of the Quaternary. Subsequently, it was isolated in the foggaras underground waters in the Great Western Erg, at approximately 320 000 years BP, creating, through a bottleneck effect, a new allopatric lineage referred to as ‘‘Adrar’’. Conversely, the high genetic diversity in the upstream Guir (Bechar) population suggests that the stock is globally in expansion. These barbels (n = 52) were also examined with meristic, morphometric, osteological, and biological features [less ▲]

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See detailDynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer Cells
Truong, Alice ULg; Yip, Cassandre ULg; PAYE, Alexandra ULg et al

in FEBS Journal (2016), 283(4), 704-22

MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes ... [more ▼]

MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes primary tumor growth and lung metastases. Although trafficking and internalization of the transmembrane MT1-MMP have been extensively investigated, little is known about the regulatory mechanisms of the GPI-anchored MT4-MMP. Here, we investigated the fate and cellular trafficking of MT4-MMP by analyzing its homophilic complex interactions, internalization and recycling dynamics compared to an inert form, MT4-MMP-E249A. Oligomeric and dimeric complexes were analyzed by co-transfection of cells with FLAG- or Myc-tagged MT4-MMP by reducing and non-reducing immunoblots and co-immunoprecipitation experiments. The trafficking of MT4-MMP was studied using an antibody feeding assay and confocal microscopy analysis or cell surface protein biotinylation and Western blot analysis. We demonstrate that MT4-MMP forms homophilic complexes at the cell surface, internalizes in early endosomes, and some of the enzyme is either auto-degraded or recycled to the cell surface. Our data indicate that MT4-MMP is internalized by the CLIC/GEEC pathway, a mechanism that differs from other MT-MMP members. Although MT4-MMP localizes with caveolin-1, MT4-MMP internalization was not affected by inhibitors of caveolin-1 or clathrin endocytosis pathways but was reduced by cdc42 or RhoA silencing with siRNA. We provide a new mechanistic insight into the regulatory mechanisms of MT4-MMP, which may have implications in the design of novel therapeutic strategies for metastatic breast cancer. This article is protected by copyright. All rights reserved. [less ▲]

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See detailEmployee Emotional Competence: Construct Conceptualization and Validation of a Customer-Based Measure
Delcourt, Cécile ULg; Gremler, Dwayne; van Riel, Allard et al

in Journal of Service Research (2016), 19(1), 72-87

Customers often experience intense emotions during service encounters. Their perceptions of how well contact employees demonstrate emotional competence in emotionally charged service encounters can affect ... [more ▼]

Customers often experience intense emotions during service encounters. Their perceptions of how well contact employees demonstrate emotional competence in emotionally charged service encounters can affect their service evaluations and loyalty intentions. Previous studies examining employees’ potential to behave in emotionally competent ways (i.e., employee emotional intelligence [EEI]) have used self- or supervisor-reported scales to predict customer outcomes, presenting EEI as stable and independent of the context. However, service firms should be more concerned with the actual display of emotionally competent behaviors by employees (employee emotional competence [EEC]), because employee behaviors vary across encounters. Moreover, a customer perspective of EEC is useful as customer perceptions of employee performance are crucial predictors of satisfaction and loyalty. Therefore, this study proposes a conceptualization and operationalization of EEC in a service encounter context. On the basis of a comprehensive literature review and in-depth interviews, the authors develop a scale to capture customer-perceived EEC, defined as an employee’s competence in perceiving, understanding, and regulating customer emotions during a discrete service encounter. The scale achieves good reliability and validity. Researchers can use it to explore the role of EEC in service contexts; managers can employ the scale to diagnose EEC and improve customers’ service encounter experiences. [less ▲]

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See detailTraumatologie du rugby à VII
KAUX, Jean-François ULg; Julia, Marc; Delvaux, François ULg et al

in Science & Sports (2016), 31(1), 1-5

Aims. — To estimate the risk of injury in rugby sevens.News. — The rugby sevens is an increasingly popular sport since the creation of the IRB SevensWorld Series in 2000 and its introduction as an Olympic ... [more ▼]

Aims. — To estimate the risk of injury in rugby sevens.News. — The rugby sevens is an increasingly popular sport since the creation of the IRB SevensWorld Series in 2000 and its introduction as an Olympic sport in 2016. Despite its strong simi-larities to rugby union, it remains a different sport with higher game intensity, causing a moresignificant number of injuries. The average incidence of injury in rugby sevens is 249.27 for1000 hours of play against 102.25 for 1000 hours of rugby union matches.Conclusion. — This epidemiological review of injuries among the rugby sevens refers to theirlocation and their nature, the causes, the position of players, the type of field, as well as thedowntime of practice following trauma. [less ▲]

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See detailOn the equivalent static load method for flexible multibody systems described with a nonlinear finite element formalism
Tromme, Emmanuel ULg; Sonneville, Valentin ULg; Bruls, Olivier ULg et al

in International Journal for Numerical Methods in Engineering (2016)

The equivalent static load (ESL) method is a powerful approach to solve dynamic response structural optimization problems. The method transforms the dynamic response optimization into a static response ... [more ▼]

The equivalent static load (ESL) method is a powerful approach to solve dynamic response structural optimization problems. The method transforms the dynamic response optimization into a static response optimization under multiple load cases. The ESL cases are defined based on the transient analysis response whereupon all the standard techniques of static response optimization can be used. In the last decade, the ESL method has been applied to perform the structural optimization of flexible components of mechanical systems modeled as multibody systems (MBS). The ESL evaluation strongly depends on the adopted formulation to describe the MBS and has been initially derived based on a floating frame of reference formulation. In this paper, we propose a method to derive the ESL adapted to a nonlinear finite element approach based on a Lie group formalism for two main reasons. Firstly, the finite element approach is completely general to analyze complex MBS and is suitable to perform more advanced optimization problems like topology optimization. Secondly, the selected Lie group formalism leads to a formulation of the equations of motion in the local frame, that turns out to be a strong practical advantage for the ESL evaluation. Examples are provided to validate the proposed method. [less ▲]

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See detailSHANNA WATERSTOWN La tornade noire venue de Floride
Sacré, Robert ULg

in ABS Magazine (2016), (49),

Interview de la chanteuse noire américaine Shanna Waterstown ; son histoire et son parcours artistique

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See detailExperimental comparison of organic fluids for low temperature ORC (organic Rankine cycle) systems for waste heat recovery applications
Desideri, Adriano ULg; Gusev, Sergei; Van den Broek, Martijn et al

in Energy (2016), 97

This contribution experimentally evaluates and compares the performance of an ORC (organic Rankine cycle) system for stationary bottoming WHR (waste heat recovery) application operating with two different ... [more ▼]

This contribution experimentally evaluates and compares the performance of an ORC (organic Rankine cycle) system for stationary bottoming WHR (waste heat recovery) application operating with two different working fluids, SES36 and R245fa. The test rig is a regenerative cycle equipped with a single screw expander modified from a standard compressor characterized by a nominal shaft power of 11 kW. A total of 36 and 43 steady-state points are collected for SES36 and R245fa respectively, over a wide range of operating conditions by changing the expander rotational speed, the pump frequency and the cooling condenser flow rate. The performances of the ORC components are individually evaluated. A maximum expander isentropic efficiency of 60% is reached using SES36 at 3000 rpm, and a value of 52% is reached with R245fa at 3000 rpm. However, for a given pressure ratio the expander output power is higher with R245fa than with SES36. The overall performance of the ORC unit are investigated in terms of first and second law efficiencies and net output power for the two fluids. The results experimentally demonstrate the correlation between the working fluid critical temperature and the ORC unit working characteristics for low temperature waste heat recovery applications. Open experimental data are provided for both fluids. [less ▲]

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See detailWalphy, un projet expérimental de réhabilitation de cours d’eau : suivis hydromorphologiques et écologiques
Castelain, Liévin; Peeters, Alexandre ULg; Halleux, Marie et al

in Hydroécologie Appliquée (2016)

Le projet Life Environnement WALPHY, co-financé par l’Union Européenne, a eu pour objectif de réaliser des travaux de restauration de la qualité hydromorphologique du Bocq, affluent de la Meuse. La ... [more ▼]

Le projet Life Environnement WALPHY, co-financé par l’Union Européenne, a eu pour objectif de réaliser des travaux de restauration de la qualité hydromorphologique du Bocq, affluent de la Meuse. La continuité longitudinale, qui concerne la libre circulation des poissons et le transport naturel des sédiments, a été fortement perturbée par un grand nombre d’obstacles (vannages, déversoirs, …). Afin de rétablir cette continuité, des travaux d’arasement ou d’aménagement (passes à bassins, bras de contournement, rampes rugueuses...) d’obstacles ont été réalisés. De plus, des travaux de reméandration, de diversification des écoulements ou de création d’habitats piscicoles ont été menés afin d’améliorer la continuité transversale. Ces travaux ont fait l’objet de suivis scientifiques sur base d’analyses géomorphologiques, hydromorphologiques et écologiques. Des méthodes standardisées et reproductibles ont été mises au point pour comparer la situation avant et après travaux. L’application de ces méthodes a montré que le suivi des microhabitats couplé à l’analyse des populations de macroinvertébrés et de poissons est à même de mettre en évidence les évolutions post-travaux. Deux exemples d’études avant et après travaux sont présentés : l’arasement d’un déversoir et la reméandration d’un secteur rectifié. Les résultats montrent une bonne évolution des indicateurs biologiques. [less ▲]

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See detailData-driven selection of the minimum-gradient support parameter in time-lapse focused electrical imaging
Nguyen, Frédéric ULg; Kemna, Andreas; Robert, Tanguy et al

in Geophysics (2016), 81(1), 1-5

We have considered the problem of the choice of the minimum-gradient support (MGS) parameter in focused inversion for time-lapse (TL) electric resistivity tomography. Most existing approaches have relied ... [more ▼]

We have considered the problem of the choice of the minimum-gradient support (MGS) parameter in focused inversion for time-lapse (TL) electric resistivity tomography. Most existing approaches have relied either on an arbitrary choice of this parameter or one based on the prior information, such as the expected contrast in the TL image. We have decided to select the MGS parameter using a line search based on the value of the TL data root-mean-square misfit at the first iteration of the nonlinear inversion procedure. The latter was based on a Gauss-Newton scheme minimizing a regularized objective function in which the regularization functional was defined by the MGS functional. The regularization parameter was optimized to achieve a certain target level, following the Occam principles. We have validated our approach on a synthetic benchmark using a complex and heterogeneous model and determined its effectiveness on electric tomography TL data collected during a salt tracer experiment in fractured limestone. Our results have determined that the approach was successful in retrieving the focused anomaly and did not rely on prior information. [less ▲]

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See detailIdentités, préférences et attitudes des parlementaires envers le fédéralisme belge après la sixième réforme de l’État
Dodeigne, Jérémy ULg; Reuchamps, Min; Sinardet, Dave

in Courrier Hebdomadaire du CRISP (2016), 33

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See detailA comparative study of models for shear strength of reinforced concrete deep beams
Liu, Jian ULg; Mihaylov, Boyan ULg

in Engineering Structures (2016), 112(April), 81-89

Since the 1960s, researchers have proposed different empirical formulas and analytical models for the shear strength of deep reinforced concrete beams. Some of these approaches have shown adequate ... [more ▼]

Since the 1960s, researchers have proposed different empirical formulas and analytical models for the shear strength of deep reinforced concrete beams. Some of these approaches have shown adequate accuracy when applied to small sets of beam tests, while their ability to predict the effect of a large range of test variables remains unknown. This paper presents a summary of models for deep beams from 73 publications, and focuses on a detailed evaluation of ten more recent models by using a database of 574 deep beam tests. It is found that a semi-empirical strut-and-tie model (STM) and a two-parameter kinematic theory (2PKT) for deep beams produce the least scattered predictions. The former model produced an average shear strength experimental-to-predicted ratio Vexp/Vpred of 1.00 with a coefficient of variation (COV) of 19.8%, while the latter resulted in an average of 1.08 with a COV of 15.4%. The two models are also compared by plotting the Vexp/Vpred ratios against different tests variables, and by performing parametric studies with individual test series. It is shown that the semi-empirical STM exhibits certain bias with respect to the shear-span-to-depth ratio, while the 2PKT produces uniform results across the entire range of experimental data. It is also noted that the semi-empirical STM requires somewhat less computational effort than the 2PKT approach. [less ▲]

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See detailCompte-rendu de l'ouvrage de S. Gatto : Blues delle zucche
Curreri, Luciano ULg

in La poesia e lo spirito (2016)

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See detailQuality Characteristics and Antioxidant Properties of Muffins Enriched with Date Fruit (Phoenix Dactylifera L.) Fiber Concentrates
Mrabet, Abdessalem ULg; Rodríguez-Gutiérrez, Guillermo; Rodríguez-Arcos, Rocío et al

in Journal of Food Quality (2016), 39(1),

Secondary varieties of date from Tunisia are underutilized due to their low commercial quality. Fiber concentrates (DFC) can be obtained from these fruits after a steam pretreatment. DFCs were evaluated ... [more ▼]

Secondary varieties of date from Tunisia are underutilized due to their low commercial quality. Fiber concentrates (DFC) can be obtained from these fruits after a steam pretreatment. DFCs were evaluated as a source of antioxidant dietary fiber for bakery products. Muffins were prepared with 2.5 and 5% flour substitution with DFCs obtained by treatments at 165 and 180C. The DFC-doughs presented a similar yield to the control but the muffins reached a lower volume. The density increase did not imply an increase in texture. In fact, the muffins with DFC-165 were the softest tested, although they had lower cohesiveness and springiness. The proximate composition was similar among samples. The DFCmuffins had higher antioxidant capacity than the control, and obtained good scores in the sensory evaluation. DFC-165 is a valuable ingredient for baked goods, but its effect on fat rancidity and staling delays should be confirmed. [less ▲]

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See detailStudy of the effect of amino-functionalized multiwall carbon nanotubes on dry sliding wear resistance properties of carbon fiber reinforced thermoset polymers
Pincheira, G.; Montalba, C.; Gacitua, W. et al

in Polymer Bulletin (2016)

This work investigates the effect of multiwall carbon nanotubes (MWCNTs) on the mechanical and tribological behavior of a fiber reinforced composite (FRC). Fiber reinforced composites and nano-engineered ... [more ▼]

This work investigates the effect of multiwall carbon nanotubes (MWCNTs) on the mechanical and tribological behavior of a fiber reinforced composite (FRC). Fiber reinforced composites and nano-engineered FRCs are manufactured by resin transfer molding. In-plane tensile tests, in-plane shear tests and through-thickness compression tests are used to assess the influence of MWCNTs on the material mechanical behavior. Pin on disk dry sliding tests are used to quantify the effect of MWCNTs on the friction coefficient and the specific wear rate. It was determined that (1) MWCNTs have an influence on the improvement on both the through-thickness compression strength and the specific wear rate, and (2) they do not influence the material stiffness, in-plane tensile and shear strengths and the friction coefficient. It is assumed that the observed improvements are due to the demonstrated positive influence of the MWCNTs effect on the matrix/reinforcement interfacial strength and on the matrix fracture toughness. [less ▲]

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See detailSoil-specific calibration of capacitance sensors considering clay content and bulk density
Parvin, Nargish ULg; Degré, Aurore ULg

in Australian Journal of Soil Research (2016)

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See detailLa médecine dans l’œil du cyclone
COUCKE, Philippe ULg

in Le spécialiste (2016)

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See detailTradeoffs between Maize Silage Yield and Nitrate Leaching in a Mediterranean Nitrate- Vulnerable Zone under Current and Projected Climate Scenarios
Basso, Bruno; Giola, Pietro; Dumont, Benjamin ULg et al

in PLoS ONE (2016), 11(1): e0146360

Future climatic changes may have profound impacts on cropping systems and affect the agronomic and environmental sustainability of current N management practices. The objectives of this work were to i ... [more ▼]

Future climatic changes may have profound impacts on cropping systems and affect the agronomic and environmental sustainability of current N management practices. The objectives of this work were to i) evaluate the ability of the SALUS crop model to reproduce experimental crop yield and soil nitrate dynamics results under different N fertilizer treatments in a farmer’s field, ii) use the SALUS model to estimate the impacts of different N fertilizer treatments on NO3- leaching under future climate scenarios generated by twenty nine different global circulation models, and iii) identify the management system that best minimizes NO3- leaching and maximizes yield under projected future climate conditions. A field experiment (maize-triticale rotation) was conducted in a nitrate vulnerable zone on the west coast of Sardinia, Italy to evaluate N management strategies that include urea fertilization (NMIN), conventional fertilization with dairy slurry and urea (CONV), and no fertilization (N0). An ensemble of 29 global circulation models (GCM) was used to simulate different climate scenarios for two Representative Circulation Pathways (RCP6.0 and RCP8.5) and evaluate potential nitrate leaching and biomass production in this region over the next 50 years. Data collected from two growing seasons showed that the SALUS model adequately simulated both nitrate leaching and crop yield, with a relative error that ranged between 0.4% and 13%. Nitrate losses under RCP8.5 were lower than under RCP6.0 only for NMIN. Accordingly, levels of plant N uptake, N use efficiency and biomass production were higher under RCP8.5 than RCP6.0. Simulations under both RCP scenarios indicated that the NMIN treatment demonstrated both the highest biomass production and NO3- losses. The newly proposed best management practice (BMP), developed from crop N uptake data, was identified as the optimal N fertilizer management practice since it minimized NO3- leaching and maximized biomass production over the long term. [less ▲]

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See detailFeasibility of improving a priori regional climate model estimates of Greenland ice sheet surface mass loss through assimilation of measured ice surface temperatures
Navari, M.; Margulis, S.A.; Bateni, S.M. et al

in Cryosphere (The) (2016), 10

The Greenland ice sheet (GrIS) has been the focus of climate studies due to its considerable impact on sea level rise. Accurate estimates of surface mass fluxes would contribute to understanding the cause ... [more ▼]

The Greenland ice sheet (GrIS) has been the focus of climate studies due to its considerable impact on sea level rise. Accurate estimates of surface mass fluxes would contribute to understanding the cause of its recent changes and would help to better estimate the past, current and future contribution of the GrIS to sea level rise. Though the estimates of the GrIS surface mass fluxes have improved significantly over the last decade, there is still considerable disparity between the results from different methodologies (e.g., Rae et al., 2012; Vernon et al., 2013). The data assimilation approach can merge information from different methodologies in a consistent way to improve the GrIS surface mass fluxes. In this study, an ensemble batch smoother data assimilation approach was developed to assess the feasibility of generating a reanalysis estimate of the GrIS surface mass fluxes via integrating remotely sensed ice surface temperature measurements with a regional climate model (a priori) estimate. The performance of the proposed methodology for generating an improved posterior estimate was investigated within an observing system simulation experiment (OSSE) framework using synthetically generated ice surface temperature measurements. The results showed that assimilation of ice surface temperature time series were able to overcome uncertainties in near-surface meteorological forcing variables that drive the GrIS surface processes. Our findings show that the proposed methodology is able to generate posterior reanalysis estimates of the surface mass fluxes that are in good agreement with the synthetic true estimates. The results also showed that the proposed data assimilation framework improves the root-mean-square error of the posterior estimates of runoff, sublimation/evaporation, surface condensation, and surface mass loss fluxes by 61, 64, 76, and 62 %, respectively, over the nominal a priori climate model estimates. [less ▲]

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See detailAssessment of thermal comfort in existing pre-1945 residential building stock
Singh, M.K.; Attia, Shady ULg; Mahapatra, Sadha et al

in Energy (2016), 98(March), 122-134

The building sector is the third-largest consumer of primary energy in Belgium. This is partly because of the high percentage of old buildings (buildings constructed before 1945) in its building stock ... [more ▼]

The building sector is the third-largest consumer of primary energy in Belgium. This is partly because of the high percentage of old buildings (buildings constructed before 1945) in its building stock. Existing international standards on thermal comfort focus primarily on new construction and commercial buildings but tend to overlook old buildings. This study involves a thermal comfort assessment of fully functional (in use) residential buildings constructed before 1945 in Liège (Belgium). The research methodology is based on continuous long term monitoring of the indoor environment (November 2011 to May 2012) and followed by comfort surveys for selected houses in the city. The analysis of the collected data shows that family composition, envelope performance and the occupants' interaction with the indoor environment greatly affected occupant preferences and functioning of the indoor thermal environment. This study reveals that the occupants' interaction with the indoor thermal environment to restore comfortable thermal conditions varies throughout the day, by adjusting the temperature in different rooms of the house at different times of the day. This study argues that modern comfort standards have failed to estimate the comfort level in these old buildings and, if applied, they would lead to under estimation of their thermal comfort. [less ▲]

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See detailTranscriptome-wide distribution and function of RNA hydroxymethylcytosine
Delatte, Benjamin; Wang, F; Ngoc, LV et al

in Science (2016), 351(6270), 282-285

Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the ... [more ▼]

Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, revealing hydroxymethylcytosine in the transcripts of many genes, notably in coding sequences, and identify consensus sites for hydroxymethylation. We found that RNA hydroxymethylation can favor mRNA translation. Tet and hydroxymethylated RNA are found to be most abundant in the Drosophila brain, and Tet-deficient fruitflies suffer impaired brain development, accompanied by decreased RNA hydroxymethylation. This study highlights the distribution, localization, and function of cytosine hydroxymethylation and identifies central roles for this modification in Drosophila. [less ▲]

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See detailAnalytical methods used to quantify isoflavones in cow's milk: a review
Daems, Frédéric ULg; Romnee, Jean-Michel; Heuskin, Stéphanie ULg et al

in Dairy Science and Technology (2016)

This paper provides an update and comprehensive review of the analytical methods used for quantifying isoflavones and their metabolites in cow’s milk. Isoflavones are secondary plant metabolites that are ... [more ▼]

This paper provides an update and comprehensive review of the analytical methods used for quantifying isoflavones and their metabolites in cow’s milk. Isoflavones are secondary plant metabolites that are similar to 17 β-estradiol in chemical structure. They form one of the most common categories of phytoestrogens. Numerous health benefits have been attributed to isoflavones, but many of these compounds are also considered to be endocrine disruptors, with adverse effects on health. These contradictory trends offer an attractive prospect for future research, and therefore, sensitive and reliable analytical methods are required to clarify various issues about isoflavones. For this review, a structured methodology was used to select 26 relevant articles published between 2005 and 2015 from the Scopus and CAB Abstract databases. The review discusses individual steps of the analytical procedures described in these articles, including sample preparation, instrumental analysis and validation. The most commonly used analytical procedure is sample preparation involving liquid-liquid extraction and an enzymatic hydrolysis step followed by liquid chromatography with mass spectrometry analysis. Currently, however, there is no standardized procedure for the sample preparation and analysis of isoflavones in milk. [less ▲]

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See detailAssessing the toxicity of Pb- and Sn-based perovskite solar cells in model organism Danio rerio
Babayigit, Aslihan; Dinh Duy Thanh, ULg; Ethirajan, Anitha et al

in Scientific Reports (2016), 6

Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite solar cells all ... [more ▼]

Intensive development of organometal halide perovskite solar cells has lead to a dramatic surge in power conversion efficiency up to 20%. Unfortunately, the most efficient perovskite solar cells all contain lead (Pb), which is an unsettling flaw that leads to severe environmental concerns and is therefore a stumbling block envisioning their large-scale application. Aiming for the retention of favorable electro-optical properties, tin (Sn) has been considered the most likely substitute. Preliminary studies have however shown that Sn-based perovskites are highly unstable and, moreover, Sn is also enlisted as a harmful chemical, with similar concerns regarding environment and health. To bring more clarity into the appropriateness of both metals in perovskite solar cells, we provide a case study with systematic comparison regarding the environmental impact of Pb- and Sn-based perovskites, using zebrafish (Danio Rerio) as model organism. Uncovering an unexpected route of intoxication in the form of acidification, it is shown that Sn based perovskite may not be the ideal Pb surrogate. [less ▲]

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See detailColor in the urban environment: A user-oriented protocol for chromatic characterization and the development of a parametric typology
Nguyen, Ngoc Luan ULg; Teller, Jacques ULg

in Color Research and Application (2016)

This article presents a user-oriented protocol that can be used to characterize chromatic attributes of an urban area. A need for both affordable and reliable assessment method of color has been observed ... [more ▼]

This article presents a user-oriented protocol that can be used to characterize chromatic attributes of an urban area. A need for both affordable and reliable assessment method of color has been observed in the field of urban design. The challenge is to provide statistical answers to these two questions: how is color organized, how does it develop its own structure in the city? The main purpose of the research is hence to investigate mean color types within the city via the implementation of a characterization tool; an urban area of the four main classes (historic center, periurban housing districts, working-class neighborhoods, and commercial zones) being characterized by a specific color palette, or a layout of specific color types. The developed instrumentation allows the assessment of the homogeneous and consistent features of an urban district. Their characterization protocol was tested through an application to several streets of the city of Liège (Belgium). [less ▲]

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See detailA comparison of two stretching programs for hamstring muscles: A randomized controlled assessor-blinded study
Demoulin, Christophe ULg; Wolfs, Sébastien ULg; Chevalier, Madeline et al

in Physiotherapy Theory & Practice (2016)

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See detailEffects of regional climate change on brown rust disease in winter wheat
JUNK, Jürgen; Kouadio, Louis; Delfosse, Philippe et al

in Climatic Change (2016)

Projected climate changes will affect wheat crop production both in the main processes of plant growth and development but also in the occurrences and severities of plant diseases. We assessed the ... [more ▼]

Projected climate changes will affect wheat crop production both in the main processes of plant growth and development but also in the occurrences and severities of plant diseases. We assessed the potential infection periods of wheat leaf rust (WLR) at two climatologically differentsites in Luxembourg. A threshold-based model, taking hourlyvalues of air temperatures, relative humidity and precipitation during night-time into account, was used for calculating favourable WLR infection days during three periods throughout the cropping season. Field experiments were conducted during the 2003–2013 period at the selected sites. Projected climate data, from a multi model ensemble of regional climate models (spatial resolution 25 km) as well as an additional projection with a higher spatial resolution of 1.3 km, were used for investigating the potential WLR infection periods for two future time spans. Results showed that the infections of WLR were satisfactorily simulated during the development of wheat at both sites for the 2003–2013 period. The probabilities of WLR detection were close to 1 and the critical success index ranged from 0.80 to 0.94 (perfect score = 1 for both). Moreover, the highest proportions of favourable days of WLR infection were simulated during spring and summer at both sites. Regional climate projections showed an increase in temperatures by 1.6 K for 2041–2050 and by 3.7 K for 2091–2100 compared to the reference period1991–2000. Positivetrends infavourableWLR infection conditions occur at both sites more conducive than in the reference period due to projected climatic conditions. [less ▲]

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See detailCollaborative analysis of multi-gigapixel imaging data using Cytomine
Marée, Raphaël ULg; Rollus, Loïc; Stévens, Benjamin et al

in Bioinformatics (2016)

Motivation: Collaborative analysis of massive imaging datasets is essential to enable scientific discoveries. Results: We developed Cytomine to foster active and distributed collaboration of ... [more ▼]

Motivation: Collaborative analysis of massive imaging datasets is essential to enable scientific discoveries. Results: We developed Cytomine to foster active and distributed collaboration of multidisciplinary teams for large-scale image-based studies. It uses web development methodologies and machine learning in order to readily organize, explore, share, and analyze (semantically and quantitatively) multi-gigapixel imaging data over the internet. We illustrate how it has been used in several biomedical applications. Availability: Cytomine (http://www.cytomine.be/) is freely available under an open-source license from http://github.com/cytomine/. A documentation wiki (http://doc.cytomine.be) and a demo server (http://demo.cytomine.be) are also available. [less ▲]

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See detailReview of M.G. Vassanji: Essays on His Works (edited by Asma Sayed)
Munos, Delphine ULg

in South Asian Diaspora (2016), online

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See detailFar beyond primary poly(vinylamine)s through free radical copolymerization and amide hydrolysis
Dréan, Mathilde ULg; Guégan, Philippe; Jérôme, Christine ULg et al

in Polymer Chemistry (2016), 7(1), 69-78

Due to their affinity for many supports, their pH responsiveness, metal binding capacity and polyelectro- lyte complexation, poly(vinylamine) derivatives have attracted attention for many applications ... [more ▼]

Due to their affinity for many supports, their pH responsiveness, metal binding capacity and polyelectro- lyte complexation, poly(vinylamine) derivatives have attracted attention for many applications including coatings, water purification, or gas membrane separation. Nevertheless, most of them possess only pendant primary amines despite the possible benefits of incorporating different amino groups along the chain. In this work, a straightforward and scalable synthesis route towards polymers bearing primary and secondary amines, as well as imidazole groups, is reported. The general strategy relies on the radical copolymerization of different vinylamides and vinyl imidazoles followed by the hydrolysis of the resulting poly(vinylamide) derivatives. Binary and ternary free radical copolymerizations of N-vinylacetamide (NVA), N-methyl vinylacetamide (NMVA) and 1-vinylimidazole (VIm) were investigated and the reactivity ratios for each copolymerization system were determined. Thanks to these values a series of statistical copolymers with predictable composition and low deviation over the chain distribution could then be synthesized. Finally, the acidic hydrolysis of the acetamide functions towards the corresponding amine was performed and optimized. Copolymers containing various pendant amino groups and with low dispersity in the chain composition could be obtained, which opens new perspectives for the above mentioned applications. [less ▲]

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See detailSpin texture induced by oxygen vacancies in strontium perovskite (001) surfaces: A theoretical comparison between SrTiO3 and SrHfO3
Garcia Castro, Andrés Camilo ULg; Vergniory, Maia G.; Bousquet, Eric ULg et al

in Physical Review B (2016), 93

The electronic structure of SrTiO3 and SrHfO3 (001) surfaces with oxygen vacancies is studied by means of first-principles calculations. We reveal how oxygen vacancies within the first atomic layer of the ... [more ▼]

The electronic structure of SrTiO3 and SrHfO3 (001) surfaces with oxygen vacancies is studied by means of first-principles calculations. We reveal how oxygen vacancies within the first atomic layer of the SrTiO3 surface (i) induce a large antiferrodistortive motion of the oxygen octahedra at the surface, (ii) drive localized magnetic moments on the Ti 3d orbitals close to the vacancies, and (iii) form a two-dimensional electron gas localized within the first layers. The analysis of the spin texture of this system exhibits a splitting of the energy bands according to the Zeeman interaction, lowering of the Ti 3dxy level in comparison with dxz and dyz, and also an in-plane precession of the spins. No Rashba-like splitting for the ground state or for the ab initio molecular dynamics trajectory at 400 K is recognized as suggested recently by A. F. Santander-Syro et al. [Nat. Mater. 13, 1085 (2014)]. Instead, a sizable Rashba-like splitting is observed when the Ti atom is replaced by a heavier Hf atom with a much larger spin-orbit interaction. However, we observe the disappearance of the magnetism and the surface two-dimensional electron gas when full structural optimization of the SrHfO3 surface is performed. Our results uncover the sensitive interplay of spin-orbit coupling, atomic relaxations, and magnetism when tuning these Sr-based perovskites. [less ▲]

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See detailProcessing of a new class of multifunctional hybrid for electromagnetic absorption based on a foam filled honeycomb
Bollen, Pierre; Quievy, Nicolas; Detrembleur, Christophe ULg et al

in Materials & Design (2016), 89

A multifunctional hybrid material class in the form of a sandwich panel has been developed towards the com- bined optimization of mechanical and electromagnetic absorption performance. The faces of the ... [more ▼]

A multifunctional hybrid material class in the form of a sandwich panel has been developed towards the com- bined optimization of mechanical and electromagnetic absorption performance. The faces of the panel are made of glass fibre reinforced epoxy composites and the core is made of carbon nanotube reinforced polymer foam filling a metallic honeycomb. The different processing strategies and options tested to fabricate the core material are described aswell as the associated scientific and technological issues. The most efficient processing route is by foaming the nanocomposite with a chemical foaming agent directly inside the honeycomb. This route offers a good surface finish and the operation can be achieved in one step. But, in order to produce large panels with a semi-continuous process, thermo-mechanical insertion of the foamed nanocomposite with supercritical CO2 can be more suitable. The characterization of the electromagnetic absorption of the panels produced by dif- ferent routes shows that the performance is not much sensitive to processing defects making possible upscaling to mass production. [less ▲]

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See detailA prospective cohort study of the clinical presentation of non-traumatic osteonecrosis of the femoral head: spine and knee symptoms as clinical presentation of hip osteonecrosis.
HAUZEUR, Jean-Philippe ULg; Malaise, Michel ULg; de MARTELAER, v

in International Orthopaedics (2016)

To study the clinical presentation of femoral head osteonecrosis (ONFH). Publications dedicated to this aspect of ONFH are rare. Our aim was to systematically collect and describe the clinical data.

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See detailComprehensive comparison of the chemical and structural characterization of landfill leachate and leonardite humic fractions
Tahiri, Abdelghani ULg; Richel, Aurore ULg; Destain, Jacqueline ULg et al

in Analytical and Bioanalytical Chemistry (2016), 408(7), 1917-1928

Humic substances (HS) are complex and heterogeneous mixtures of organic compounds that occur everywhere in the environment. They represent most of the dissolved organic matter in soils, sediments (fossil ... [more ▼]

Humic substances (HS) are complex and heterogeneous mixtures of organic compounds that occur everywhere in the environment. They represent most of the dissolved organic matter in soils, sediments (fossil), water, and landfills. The exact structure of HS macromolecules has not yet been determined because of their complexity and heterogeneity. Various descriptions of HS are used depending on specific environments of origin and research interests. In order to improve the understanding of the structure of HS extracted from landfill leachate (LHS) and commercial HS from leonardite (HHS), this study sought to compare the composition and characterization of the structure of LHS and HHS using elemental composition, chromatographic (high-performance liquid chromatography (HPLC)), and spectroscopic techniques (UV–vis, FTIR, NMR, and MALDI-TOF). The results showed that LHS molecules have a lower molecular weight and less aromatic structure than HHS molecules. The characteristics of functional groups of both LHS and HHS, however, were basically similar, but there was some differences in absorbance intensity. There were also less aliphatic and acidic functional groups and more aromatic and polyphenolic compounds in the humic acid (HA) fraction than in the fulvic acid (FA) and other molecules (OM) fractions of both origins. The differences between LHS and HHS might be due to the time course of humification. Combining the results obtained from these analytical techniques cold improve our understanding of the structure of HS of different origins and thus enhance their potential use. [less ▲]

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See detailVariability in the super-Earth 55 Cnc e
Demory, Brice-Olivier; Gillon, Michaël ULg; Madhusudhan, Nikku et al

in Monthly Notices of the Royal Astronomical Society (2016), 455

Considerable progress has been made in recent years in observations of atmospheric signatures of giant exoplanets, but processes in rocky exoplanets remain largely unknown due to major challenges in ... [more ▼]

Considerable progress has been made in recent years in observations of atmospheric signatures of giant exoplanets, but processes in rocky exoplanets remain largely unknown due to major challenges in observing small planets. Numerous efforts to observe spectra of super-Earths, exoplanets with masses of 1-10 Earth masses, have thus far revealed only featureless spectra. In this paper, we report a 4σ detection of variability in the dayside thermal emission from the transiting super-Earth 55 Cancri e. Dedicated space-based monitoring of the planet in the mid-infrared over eight eclipses revealed the thermal emission from its dayside atmosphere varying by a factor of 3.7 between 2012 and 2013. The amplitude and trend of the variability are not explained by potential influence of star spots or by local thermal or compositional changes in the atmosphere over the short span of the observations. The possibility of large-scale surface activity due to strong tidal interactions possibly similar to Io, or the presence of circumstellar/circumplanetary material appear plausible and motivate future long-term monitoring of the planet. [less ▲]

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See detailInsan her şeyin ölçüsü şüdür? Çağdas dünya ısiğinda Protagoras
Gavray, Marc-Antoine ULg

in Sabah Ülkesi (2016), 46

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See detailCOSMOGRAIL: the COSmological MOnitoring of GRAvItational Lenses. XV. Assessing the achievability and precision of time-delay measurements
Bonvin, V.; Tewes, M.; Courbin, F. et al

in Astronomy and Astrophysics (2016), 585

COSMOGRAIL is a long-term photometric monitoring of gravitationally lensed quasars aimed at implementing Refsdal's time-delay method to measure cosmological parameters, in particular H[SUB]0[/SUB]. Given ... [more ▼]

COSMOGRAIL is a long-term photometric monitoring of gravitationally lensed quasars aimed at implementing Refsdal's time-delay method to measure cosmological parameters, in particular H[SUB]0[/SUB]. Given the long and well sampled light curves of strongly lensed quasars, time-delay measurements require numerical techniques whose quality must be assessed. To this end, and also in view of future monitoring programs or surveys such as the LSST, a blind signal processing competition named Time Delay Challenge 1 (TDC1) was held in 2014. The aim of the present paper, which is based on the simulated light curves from the TDC1, is double. First, we test the performance of the time-delay measurement techniques currently used in COSMOGRAIL. Second, we analyse the quantity and quality of the harvest of time delays obtained from the TDC1 simulations. To achieve these goals, we first discover time delays through a careful inspection of the light curves via a dedicated visual interface. Our measurement algorithms can then be applied to the data in an automated way. We show that our techniques have no significant biases, and yield adequate uncertainty estimates resulting in reduced χ[SUP]2[/SUP] values between 0.5 and 1.0. We provide estimates for the number and precision of time-delay measurements that can be expected from future time-delay monitoring campaigns as a function of the photometric signal-to-noise ratio and of the true time delay. We make our blind measurements on the TDC1 data publicly available. [less ▲]

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See detailANIMA: A data-sharing initiative for neuroimaging meta-analyses
Reid, Andrew T.; Bzdok, Danilo; Genon, Sarah ULg et al

in NeuroImage (2016), 124(B), 1245-1253

Meta-analytic techniques allow cognitive neuroscientists to pool large amounts of data across many individual task-based functional neuroimaging experiments. These methods have been aided by the ... [more ▼]

Meta-analytic techniques allow cognitive neuroscientists to pool large amounts of data across many individual task-based functional neuroimaging experiments. These methods have been aided by the introduction of online databases such as Brainmap.org or Neurosynth.org, which collate peak activation coordinates obtained from thousands of published studies. Findings from meta-analytic studies typically include brain regions which are consistently activated across studies for specific contrasts, investigating cognitive or clinical hypotheses. These regions can be subsequently used as the basis for seed-based connectivity analysis, or formally compared to neuroimaging data in order to help interpret new findings. To facilitate such approaches, we have developed a new online repository of meta-analytic neuroimaging results, named the Archive of Neuroimaging Meta-analyses (ANIMA). The ANIMA platform consists of an intuitive online interface for querying, downloading, and contributing data from published meta-analytic studies. Additionally, to aid the process of organizing, visualizing, and working with these data, we present an open-source desktop application called Volume Viewer. Volume Viewer allows users to easily arrange imaging data into composite stacks, and save these sessions as individual files, which can also be uploaded to the ANIMA database. The application also allows users to perform basic functions, such as computing conjunctions between images, or extracting regions-of-interest or peak coordinates for further analysis. The introduction of this new resource will enhance the ability of researchers to both share their findings and incorporate existing meta-analytic results into their own research. [less ▲]

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See detailAmplitude and frequency variations of oscillation modes in the pulsating DB white dwarf star KIC~08626021. The likely signature of nonlinear resonant mode coupling
Zong, W.; Charpinet, S.; Vauclair, G. et al

in Astronomy and Astrophysics (2016), 585

Context. The signatures of nonlinear effects affecting stellar oscillations are difficult to observe from ground observatories because of the lack of continuous high-precision photometric data spanning ... [more ▼]

Context. The signatures of nonlinear effects affecting stellar oscillations are difficult to observe from ground observatories because of the lack of continuous high-precision photometric data spanning extended enough time baselines. The unprecedented photometric quality and coverage provided by the Kepler spacecraft offers new opportunities to search for these phenomena. Aims: We use the Kepler data accumulated on the pulsating DB white dwarf KIC 08626021 to explore in detail the stability of its oscillation modes, searching, in particular, for evidence of nonlinear behaviors. Methods: We analyze nearly two years of uninterrupted short-cadence data, concentrating on identified triplets that are caused by stellar rotation and that show intriguing behaviors during the course of the observations. Results: We find clear signatures of nonlinear effects that could be attributed to resonant mode coupling mechanisms. These couplings occur between the components of the triplets and can induce different types of behaviors. We first notice that a structure at 3681 μHz, identified as a triplet in previous published studies, is in fact forming a doublet, with the third component being an independent mode. We find that a triplet at 4310 μHz and this doublet at 3681 μHz (most likely the two visible components of an incomplete triplet) have clear periodic frequency and amplitude modulations, which are typical of the so-called intermediate regime of the resonance, with timescales consistent with theoretical expectations. Another triplet at 5073 μHz is likely in a narrow transitory regime in which the amplitudes are modulated while the frequencies are locked. Using nonadiabatic pulsation calculations, based on a model representative of KIC 08626021 to evaluate the linear growth rates of the modes in the triplets, we also provide quantitative information that could be useful for future comparisons with numerical solutions of the amplitude equations. Conclusions: The observed modulations are the clearest hints of nonlinear resonant couplings occurring in white dwarf stars identified so far. These should resonate as a warning to projects that aim at measuring the evolutionary cooling rate of KIC 08626021, and of white dwarf stars in general. Nonlinear modulations of the frequencies can potentially jeopardize any attempt to measure such rates reliably, unless they can be corrected beforehand. These results should motivate further theoretical work to develop the nonlinear stellar pulsation theory. [less ▲]

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See detailEffects of seed traits variation on seedling performance of the invasive weed, Ambrosia artemisiifolia L.
Ortmans, William ULg; Mahy, Grégory ULg; Monty, Arnaud ULg

in Acta Oecologica: International Journal of Ecology (2016), 71

Seedling performance can determine the survival of a juvenile plant and impact adult plant performance. Understanding the factors that may impact seedling performance is thus critical, especially for ... [more ▼]

Seedling performance can determine the survival of a juvenile plant and impact adult plant performance. Understanding the factors that may impact seedling performance is thus critical, especially for annuals, opportunists or invasive plant species. Seedling performance can vary among mothers or populations in response to environmental conditions or under the influence of seed traits. However, very few studies have investigated seed traits variations and their consequences on seedling performance. Specifically, the following questions have been addressed by this work: 1) How the seed traits of the invasive Ambrosia artemisiifolia L. vary among mothers and populations, as well as along the latitude; 2) How do seed traits influence seedling performance; 3) Is the influence on seedlings temperature dependent. With seeds from nine Western Europe ruderal populations, seed traits that can influence seedling development were measured. The seeds were sown into growth chambers with warmer or colder temperature treatments. During seedling growth, performance-related traits were measured. A high variability in seed traits was highlighted. Variation was determined by the mother identity and population, but not latitude. Together, the temperature, population and the identity of the mother had an effect on seedling performance. Seed traits had a relative impact on seedling performance, but this did not appear to be temperature dependent. Seedling performance exhibited a strong plastic response to the temperature, was shaped by the identity of the mother and the population, and was influenced by a number of seed traits. [less ▲]

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See detailLa psychothérapie institutionnelle : un processus thérapeutique au service de la régulation émotionnelle et de l'empathie
Triffaux, Jean-Marc ULg; Gernay, Delphine; Servais, Catherine et al

in Encéphale (L') (2016)

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See detailImpact of three phtalate esters on the sexual reproduction of the Monogont rotifer, Brachionus calyciflorus
Cruciani, Valentina ULg; Iovine, Catherine; Thomé, Jean-Pierre ULg et al

in Ecotoxicology (2016), 25(1), 192-200

Phthalate esters are widespread contaminants that can cause endocrine disruption in vertebrates. Studies showed that molecules with hormonal activities in vertebrates and invertebrates can affect asexual ... [more ▼]

Phthalate esters are widespread contaminants that can cause endocrine disruption in vertebrates. Studies showed that molecules with hormonal activities in vertebrates and invertebrates can affect asexual and sexual reproduction in rotifers. We investigated the impact of di-hexylethyl phthalate (DEHP), di-butyl phthalate (DBP) and butylbenzyl phthalate (BBP), on the asexual and sexual reproduction of the freshwater monogonont rotifer Brachionus calyciflorus in order to determine a potential environmental risk for sexual reproduction. We observed that DEHP has no significant impact on both asexual and sexual reproduction up to 2 mg/L. DBP has a positive effect on asexual reproduction at concentrations from 0.05 to 1mg/L, but depresses it at 2 mg/L. Sexual reproduction is only affected with 2mg/L and the impact observed is negative. BBP displayed a negative impact on both asexual and sexual reproduction at 1 and 2 mg/L. However we showed that the impacts of BBP on fertilization rates observed are due to the decrease in population growth rates at these concentrations and are not due to a direct impact of BBP on the fertilization process. Similar conclusions are likely applicable to the impacts on mixis and production of cysts as well. Our results show that sexual reproduction in B. calyciflorus is not more sensitive than asexual reproduction to any of the substances tested which indicates the mode of action of these molecules is related to general toxicity, not to an interference with potential endocrine regulation of sexual reproduction. Comparison of effect concentrations and surface water contamination by phthalate esters suggests these compounds do not constitute a risk for these environments. [less ▲]

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See detailIdentification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.
Umelo, Ijeoma ULg; Noeparast, Amir; Chen, Gang et al

in Oncotarget (2016), 7(3), 3068-83

Somatic mutations found within the tyrosine kinase domain (TKD) of the human epidermal growth factor (HER) family of receptors have been implicated in the development and progression of non-small cell ... [more ▼]

Somatic mutations found within the tyrosine kinase domain (TKD) of the human epidermal growth factor (HER) family of receptors have been implicated in the development and progression of non-small cell lung cancer (NSCLC). However, no conclusive reports have described pathogenic mutations in kinase-impaired HER3. Here, we report a case of an advanced chemotherapy-resistant NSCLC, harboring a novel HER3V855A somatic mutation homologous to the EGFRL858Ractivating mutation. Co-expression of HER3V855A and wild-type HER2 enhances ligand-induced transformation of murine and human cell lines, while HER-targeted inhibitors potently suppress mutant HER3 activity. Consistent with these observations, in silico computational modeling predicts that mutant V855A alters the kinase domain and c-terminal end of the HER3 protein. Taken together, these findings provide a basis for the clinical exploration of targeted therapies in HER3 mutant NSCLC and by extrapolation, in other cancers that more frequently carry somatic HER3 mutations. [less ▲]

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See detail2D dynamic studies combined with the surface curvature analysis to predict Arias Intensity amplification
Torgoev, Almazbek ULg; Havenith, Hans-Balder ULg

in Journal of Seismology (2016)

A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings ... [more ▼]

A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings of the landslide-prone slopes situated in the Mailuu-Suu River Valley, Southern Kyrgyzstan. The main studied parameter is the Arias Intensity (Ia, m/sec), which is applied in the GIS-based Newmark method to regionally map the seismically-induced landslide susceptibility. This method maps the Ia values via empirical attenuation laws and our studies investigate a potential to include topographic input into them. Numerical studies analyse several signals with varying shape and changing central frequency values. All tests demonstrate that the spectral amplification patterns directly affect the amplification of the Ia values. These results let to link the 2D distribution of the topographically amplified Ia values with the parameter called as smoothed curvature. The amplification values for the low-frequency signals are better correlated with the curvature smoothed over larger spatial extent, while those values for the high-frequency signals are more linked to the curvature with smaller smoothing extent. The best predictions are provided by the curvature smoothed over the extent calculated according to Geli’s law. The sample equations predicting the Ia amplification based on the smoothed curvature are presented for the sinusoid-shape input signals. These laws cannot be directly implemented in the regional Newmark method, as 3D amplification of the Ia values addresses more problem complexities which are not studied here. Nevertheless, our 2D results prepare the theoretical framework which can potentially be applied to the 3D domain and, therefore, represent a robust basis for these future research targets. [less ▲]

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See detailPremière consultation de contraception chez les adolescentes
BELIARD, Aude ULg

in Revue Médicale de Liège (2016), 71(1), 28-33

Adequate contraception prescription is mandatory for teenagers to avoid any unwanted pregnancy. Counselling and description of side effect improve compliance. Use of condom is important to avoid sexually ... [more ▼]

Adequate contraception prescription is mandatory for teenagers to avoid any unwanted pregnancy. Counselling and description of side effect improve compliance. Use of condom is important to avoid sexually transmitted infections. Combined estroprogestin contraception has multiple non-contraceptive benefits, e.g. dysmenorrhea improvement. Familial and personal history is needed before contraception prescription. Further consultation 3 months later has to be planned to evaluate compliance, side effects and to adapt contraception if needed. [less ▲]

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See detailCompte-rendu de : GÉRARD E., DE RIDDER W., MULLER F., Qui a tué Julien Lahaut ? Les ombres de la Guerre Froide en Belgique, Bruxelles, La Renaissance du Livre, 2015, 352 p.
Genin, Vincent ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2016), XXXVII(2015/4), 21-24

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (2016), 41(1), 113-130

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailShaping Pulses to Control Bistable Systems: Analysis, Computation and Counterexamples
Sootla, Aivar ULg; Oyarzun, Diego; Angeli, David et al

in Automatica (2016), 63

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See detailAn Economic Appraisal of MOOC Platforms: Business Models and Impacts on Higher Education
Jacqmin, Julien ULg; belleflamme, paul

in CESifo Economic Studies (2016), 62(1), 148-169

We use various economic and pedagogical concepts to understand the specificities of MOOC (Massive Online Open Courses) platforms. We discuss how the private provision of MOOCs can be sustained. Using the ... [more ▼]

We use various economic and pedagogical concepts to understand the specificities of MOOC (Massive Online Open Courses) platforms. We discuss how the private provision of MOOCs can be sustained. Using the theory of multisided platforms, we analyze five ways to monetize the MOOC business. We then claim that MOOC platforms can play a key transformative role in the higher education sector by making teaching practices evolve, rather than by replacing incumbent institutions. Finally, we derive a number of directions for public policy [less ▲]

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See detailProvenance of Ichthyosaura alpestris (Caudata: Salamandridae) introductions to France and New Zealand assessed by mitochondrial DNA analysis
Arntzen, Jan W.; King, Tania M.; Denoël, Mathieu ULg et al

in The Herpetological Journal (2016), 26(1), 49-56

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a ... [more ▼]

The last century has seen an unparalleled movement of species around the planet as a direct result of human activity, which has been a major contributor to the biodiversity crisis. Amphibians represent a particularly vulnerable group, exacerbated by the devastating effects of chytrid fungi. We report the malicious translocation and establishment of the alpine newt (Ichthyosaura alpestris) to its virtual antipode in North Island of New Zealand. We use network analysis of mitochondrial DNA haplotypes to identify the original source population as I. a. apuana from Tuscany, Italy. Additionally, a population in southern France, presumed to be introduced, is identified as I. a. alpestris from western Europe. However, the presence of two differentiated haplotypes suggests a mixed origin. This type of analysis is made possible by the recent availability of a phylogenetic analysis of the species throughout its natural range. We discuss the particulars of both introductions. [less ▲]

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See detailQuand la force enfonce des portes ouvertes. Analyse du traitement de Star Wars Episode VII par la critique professionnelle et amateure.
Krywicki, Boris ULg

in Culture, le Magazine Culturel de l'Université de Liège (2016)

On a rarement aperçu des phénomènes cinématographiques de l’ampleur de Star Wars. La plupart des séances étaient déjà complètes plusieurs semaines avant la sortie du dernier épisode. Les spectateurs sont ... [more ▼]

On a rarement aperçu des phénomènes cinématographiques de l’ampleur de Star Wars. La plupart des séances étaient déjà complètes plusieurs semaines avant la sortie du dernier épisode. Les spectateurs sont tous conquis en amont par ce messie monolithique. Quand il s'agit d'aborder un film-événement comme Star Wars, la critique de cinéma se cherche. Les timides tentatives de la rigide presse professionnelle qui hésite toujours à critiquer les productions hollywoodiennes font face à des vidéos de youtubeurs décomplexés. Cet article analyse les contrats de lecture de ces différents énonciateurs et le lecteur-modèle qu'ils envisagent pour traiter de Star Wars Episode VII. [less ▲]

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See detailApprendre à faire semblant. A propos de "Furyo" de Nagisa Oshima
Tomasovic, Dick ULg

in Mondes du cinéma (2016), 08

Une analyse des préceptes qui gouvernent la mise en scène du film "Furyo" d’Oshima, en insistant particulièrement sur l'analyse de la bande sonore et la présence à l'écran de David Bowie et Ryuichi ... [more ▼]

Une analyse des préceptes qui gouvernent la mise en scène du film "Furyo" d’Oshima, en insistant particulièrement sur l'analyse de la bande sonore et la présence à l'écran de David Bowie et Ryuichi Sakamoto. [less ▲]

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See detailBreakdown of Anderson localization in the transport of Bose-Einstein condensates through one-dimensional disordered potentials
Dujardin, Julien ULg; Engl, Thomas; Schlagheck, Peter ULg

in Physical Review A (2016), 93

We study the transport of an interacting Bose–Einstein condensate through a 1D correlated disorder potential. We use for this purpose the truncated Wigner method, which is, as we show, corresponding to ... [more ▼]

We study the transport of an interacting Bose–Einstein condensate through a 1D correlated disorder potential. We use for this purpose the truncated Wigner method, which is, as we show, corresponding to the diagonal approximation of a semiclassical van Vleck–Gutzwiller representation of this many-body transport process. We also argue that semiclassical corrections beyond this diagonal approximation are vanishing under disorder average, thus confirming the validity of the truncated Wigner method in this context. Numerical calculations show that, while for weak atom-atom interaction strengths Anderson localization is preserved with a slight modification of the localization length, for larger interaction strengths a crossover to a delocalized regime exists due to inelastic scattering. In this case, the transport is fully incoherent. [less ▲]

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See detailThe Relationship between the Profile of Manager and Management Accounting Practices in Tunisian SMIs
Ghorbel, Jihene ULg

in International Journal of Academic Research in Accounting, Finance and Management Sciences (2016), 6(1), 61-72

In today’s changing environment, SMEs must strengthen their competitiveness and credibility with all their external partners. So to survive and prosper, managers need adequate management practices in ... [more ▼]

In today’s changing environment, SMEs must strengthen their competitiveness and credibility with all their external partners. So to survive and prosper, managers need adequate management practices in order to provide relevant accounting information. This paper examines the effect of profile of manager on management accounting practices which was defined in terms of traditional management accounting, modern management accounting and management accounting practices related to export. As to the profile of manager, it is defined by age, type of training and experience. To validate the hypotheses, a multiple linear regression method is used. The data is collected by questionnaire from 221 Tunisian manufacturing SMEs. The findings indicate that the profile of manager affect in part the use of management accounting practices. [less ▲]

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See detailAutomatic artifacts and arousals detection in whole-night sleep EEG recordings
Coppieters't Wallant, Dorothée ULg; Muto, Vincenzo ULg; Gaggioni, Giulia ULg et al

in Journal of Neuroscience Methods (2016), 258

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time ... [more ▼]

In sleep electroencephalographic (EEG) signals, artifacts and arousals marking are usually part of the processing. This visual inspection by a human expert has two main drawbacks: it is very time consuming and subjective. To detect artifacts and arousals in a reliable, systematic and reproducible automatic way, we developed an automatic detection based on time and frequency analysis with adapted thresholds derived from data themselves. The automatic detection performance is assessed using 5 statistic parameters, on 60 whole night sleep recordings coming from 35 healthy volunteers (male and female) aged between 19 and 26. The proposed approach proves its robustness against inter- and intra-, subjects and raters’ scorings, variability. The agreement with human raters is rated overall from substantial to excellent and provides a significantly more reliable method than between human raters. Existing methods detect only specific artifacts or only arousals, and/or these methods are validated on short episodes of sleep recordings, making it difficult to compare with our whole night results. The method works on a whole night recording and is fully automatic, reproducible, and reliable. Furthermore the implementation of the method will be made available online as open source code. [less ▲]

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See detailSmall-Angle Neutron Scattering investigation of cholesterol-doped DMPC liposomes interacting with β-cyclodextrin
Joset, Arnaud ULg; Grammenos, Angeliki; Hoebeke, Maryse ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2016), 84(1), 153-161

The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC ... [more ▼]

The Small-Angle Neutron Scattering technique (SANS) has been applied to characterize the influence of a randomly methylated β–cyclodextrin (CD), called RAMEB, on dimyristoylphosphatidylcholine (DMPC) liposomes doped with cholesterol. From the modelling of the experimental neutron scattering crosssections, the detailed response of the vesicle structure upon addition of increasing amounts of RAMEB up to 30 mM has been assessed. This study has been performed below and above the DMPC bilayer phase transition temperature and shows that cholesterol extraction by RAMEB is linked to a decrease of the average radius and of the aggregation number of the vesicles. This extraction takes place in a dose-dependent way until a more monodisperse population of cholesterol-free liposomes was obtained. In addition, the bilayer thickness evolution was inferred, as well as the liposome coverage by RAMEB. [less ▲]

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See detailFLOR-ID: an interactive database of flowering-time gene networks in Arabidopsis thaliana
Bouché, Frédéric ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

in Nucleic Acids Research (2016), 44(Database), 11671171

Flowering is a hot topic in Plant Biology and important progress has been made in Arabidopsis thaliana toward unravelling the genetic networks involved. The increasing complexity and the explosion of ... [more ▼]

Flowering is a hot topic in Plant Biology and important progress has been made in Arabidopsis thaliana toward unravelling the genetic networks involved. The increasing complexity and the explosion of literature however require development of new tools for information management and update. We therefore created an evolutive and interactive database of flowering time genes, named FLOR-ID (Flowering-Interactive Database), that is available freely at http://www.flor-id.org. The hand-curated database contains information on 306 genes and links to 1595 publications gathering the work of more than 4500 authors. Gene function and interactions within the flowering pathways were inferred from the analysis of related publications, included in the database and translated into interactive manually drawn snapshots. [less ▲]

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See detailProjecting alternative urban growth patterns: The development and application of a remote sensing assisted calibration framework for the Greater Dublin Area
Van de Voorde, Tim; van der Kwast, Johannes; Poelmans, Lien et al

in Ecological Indicators (2016), 60

Land use change models are powerful tools that allow planners and policy makers to assess the long-term spatial and environmental impacts of their decisions. In order for these models to produce a ... [more ▼]

Land use change models are powerful tools that allow planners and policy makers to assess the long-term spatial and environmental impacts of their decisions. In order for these models to produce a realistic output, they should be properly calibrated. This is usually achieved by comparing simulated land-use maps of dates in the past to reference land-use maps of a corresponding date. As land-use data are often not readily or frequently available, we propose a two-stage calibration framework that includes existing land-use maps as well as remote sensing derived maps of the urban extent. Urban growth patterns for the Dublin area represented by remote sensing based maps were compared to simulated growth using spatial metrics in order to fine-tune the calibration of the MOLAND urban growth model of Dublin. We then used the calibrated model to forecast future urban growth according to four urban planning scenarios that have been defined for the Strategic Environmental Assessment of the Greater Dublin Area. We examined a selection of spatial metrics in order to determine their sensitivity to differences in spatial patterns between simulated and remote sensing derived data. We also investigated whether these metrics are useful to characterise future changes in the urban spatial structure that ensue from the planning scenarios. We found that with the exception of some metrics that strongly respond to differences in the amount of urban land, most metrics showed similar trends for simulated and remote sensing derived maps. Most metrics were also able to distinguish the growth patterns induced by the different spatial planning scenarios. The “business as usual scenario” in particular showed a clearly distinct trend compared to the other scenarios. We could also conclude that the urban growth pattern of Dublin as observed from both the remote sensing derived maps and the simulated maps of future land use seems to confirm the theory of alternating phases of diffusive growth and coalescence. [less ▲]

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See detailPre-employement examination for low back risk in workers exposesd to manual handling of loads : French guidelines
PETIT, Audrey; ROUSSEAU, Sandrine; HUEZ, Jean-François et al

in International Archives of Occupational and Environmental Health (2016), 89

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See detailRe-visiting plant plasma membrane lipids in tobacco: a focus on sphingolipids
Cacas, Jean Luc; Buré, Corinne; Grosjean, Kevin et al

in Plant Physiology (2016), 170

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See detailCross-Modal Decoding of Neural Patterns Associated with Working Memory: Evidence for Attention-Based Accounts of Working Memory
Majerus, Steve ULg; Cowan, Nelson; Peters, Frédéric ULg et al

in Cerebral Cortex (2016), 26

Recent studies suggest common neural substrates involved in verbal and visual working memory (WM), interpreted as reflecting shared attention-based, short-term retention mechanisms. We used a machine ... [more ▼]

Recent studies suggest common neural substrates involved in verbal and visual working memory (WM), interpreted as reflecting shared attention-based, short-term retention mechanisms. We used a machine-learning approach to determine more directly the extent to which common neural patterns characterize retention in verbal WM and visual WM. Verbal WM was assessed via a standard delayed probe recognition task for letter sequences of variable length. Visual WM was assessed via a visual array WM task involving the maintenance of variable amounts of visual information in the focus of attention. We trained a classifier to distinguish neural activation patterns associated with high- and low-visual WM load and tested the ability of this classifier to predict verbal WM load (high–low) from their associated neural activation patterns, and vice versa. We observed significant between-task prediction of load effects during WM maintenance, in posterior parietal and superior frontal regions of the dorsal attention network; in contrast, between-task prediction in sensory processing cortices was restricted to the encoding stage. Furthermore, between-task prediction of load effects was strongest in those participants presenting the highest capacity for the visual WM task. This study provides novel evidence for common, attention-based neural patterns supporting verbal and visual WM. [less ▲]

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See detailL’infraction d’obstacle à la surveillance sous le spectre du droit au silence et du droit de ne pas s’auto-incriminer
Michiels, Olivier ULg; Falque, Géraldine ULg

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2016), (2006/1), 2-11

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne ... [more ▼]

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne pas s'auto-incriminer. Il envisage encore la cohabitation entre le délit d'obstacle et le droit au silence sous l’angle de la jurisprudence de la Cour européenne des droits de l’homme et du droit interne. [less ▲]

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See detailGenetic diversity and population structure of the Eurosian otte (Lutra lutra) in France
Geboes, Anne-Laure ULg; Rosoux, René; Lemarchand, Charles et al

in Mammal Research (2016), 61(1),

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before ... [more ▼]

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before the recolonisation process, two main populations still remained along the Atlantic coast and in the Massif Central. To investigate the impact of this decline on the genetic diversity and structure of the French otter population, tissue samples of 144 otter carcasses from road kills that were found during 1992–2011 along the Atlantic coast and in the Massif Central were used. They were analysed using 10 microsatellites loci. Observed (Ho = 0.64) and expected heterozygosity (He = 0.62) were moderate, but consistent with results found in other European populations. The bottleneck test showed an excess of heterozygotes, providing evidence of a recent decline. There was evidence for weak but significant allelic frequencies divergence between otters from the Atlantic coast and those from the Massif Central (Fst=0.040, p<0.05), probably resulting from their isolation prior to the recolonisation process. As the French otter population has been expanding for several years, genetic intermixing is now occurring. Although this expansion has not yet genetically homogenised all populations, this is may be a matter a time. [less ▲]

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See detailElectrical resistivity tomography to monitor enhanced biodegradation of hydrocarbons with Rhodococcus erythropolis T902.1 at a pilot scale
Masy, Thibaut ULg; Caterina, David; Tromme, Oliver et al

in Journal of Contaminant Hydrology (2016), 184

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of ... [more ▼]

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of such a technique (by biostimulation or bioaugmentation) strongly depends on the environment affected and is still difficult to predict a priori. In order to overcome these uncertainties, Electrical Resistivity Tomography (ERT) appears as a valuable non-invasive tool to detect soil heterogeneities and to monitor biodegradation. The main objective of this study was to isolate an electrical signal linked to an enhanced bacterial activity with ERT, in an aged HC-contaminated clayey loam soil. To achieve this, a pilot tank was built to mimic field conditions. Compared to a first insufficient biostimulation phase, bioaugmentation with Rhodococcus erythropolis T902.1 led to a HC depletion of almost 80% (6900 to 1600 ppm) in 3 months in the center of the contaminated zone, where pollutants were less bioavailable. In the meantime, lithological heterogeneities and microbial activities (growth and biosurfactant production) were successively discriminated by ERT images. In the future, this cost-effective technique should be more and more transferred to the field in order to monitor biodegradation processes and assist in selecting the most appropriate remediation technique. [less ▲]

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See detailL'observation foncière en France, à Bruxelles et en Flandre
Hendrickx, Sébastien ULg; Sarciat, Jordane ULg; Halleux, Jean-Marie ULg

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2016), 64

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques ... [more ▼]

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques d’aménagement du territoire et des politiques sectorielles. La note de recherche n° 64 s’intéresse aux pratiques d’observation dans les territoires adjacents à la Wallonie et plus exactement aux outils développés en France, en Flandre et en Région de Bruxelles-Capitale. L’analyse de ces différents cas a mis en exergue l'avance évidente de nos voisins sur ces problématiques et permet d'apprécier l’utilité d’une connaissance territoriale accrue pour l’élaboration des stratégies de développement territorial et pour la prise de décision politique. Elle aboutit à diverses recommandations relatives à l’amélioration du système d’informations foncières et des politiques foncières en Wallonie. [less ▲]

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See detailComment je traite... la sténose aortique asymptomatique
MEURICE, Caroline ULg; DULGHERU, Raluca Elena ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), (71), 6-10

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See detailDoes the Budyko curve reflect a maximum power state of hydrological systems? A backward analysis
Westhoff, Martijn ULg; Zehe, Erwin; Archambeau, Pierre ULg et al

in Hydrology and Earth System Sciences (2016), 20

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we ... [more ▼]

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we applied the thermodynamic principle of maximum power as the organizing principle. In a top-down approach we derived mathematical formulations of the relation between relative wetness and gradients driving runoff and evaporation for a simple one-box model. We did this in an inverse manner such that when the conductances are optimized with the maximum power principle, the steady state behaviour of the model leads exactly to a point on the asymptotes of the Budyko curve. Subsequently, we added dynamics in forcing and actual evaporations, causing the Budyko curve to deviate from the asymptotes. Despite the simplicity of the model, catchment observations compare reasonably well with the Budyko curves subject to observed dynamics in rainfall and actual evaporation. Thus by constraining the model with the asymptotes of the Budyko curve we were able to derive more realistic values of the aridity and evaporation index without any calibration parameter. Future work should focus on better representing the boundary conditions of real catchments and eventually adding more complexity to the model. [less ▲]

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See detailCost-effectiveness of personalized supplementation with vitamin D-rich dairy products in the prevention of osteoporotic fractures
Ethgen, Olivier ULg; Hiligsmann, Mickaël; Burlet, Nansa et al

in Osteoporosis International (2016), 27

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of ... [more ▼]

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of osteoporotic fractures. Introduction: The objective of this study is to assess the costeffectiveness of the vitamin D-fortified yogurt given to women with and without an increased risk of osteoporotic fracture. Methods: Avalidated cost-effectiveness microsimulation Markov model of osteoporosis management was used. Three personalized supplementation scenarios to reflect the Ca/Vit D needs taking into account the well-known variations in dietary habits and a possible pharmacological supplementation in Ca/ Vit D, given above or in combination with anti-osteoporosis medications: one yogurt per day, i.e., 400 mg of Ca+200 IU of Vit D (scenario 1 U), two yogurts per day, i.e., 800 mg of Ca+ 400 IU of Vit D (scenario 2 U), or three yogurts per day, i.e., 1, 200 mg of Ca+600 IU of Vit D (scenario 3 U). Results: One yogurt is cost-effective in the general population above the age of 70 years and in all age groups in women with low bone mineral density (BMD) or prevalent vertebral fracture (PVF). The daily intake of two yogurts is cost-effective above 80 years in the general population and above 70 years in the two groups of women at increased risk of fractures. However, an intake of three yogurts per day is only cost-effective above 80 years old in the general population, as well as in women with low BMD or PVF. Conclusions: Our study is the first economic analysis supporting the cost-effectiveness of dairy products, fortified with vitamin D, in the armamentarium against osteoporotic fractures. [less ▲]

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See detailOverview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in American Journal of Analytical Chemistry (2016), 7

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See detailNos différences, une richesse
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailL'intentionnalité cognitive et ses modes. Reinach critique de Brentano
Dewalque, Arnaud ULg

in Philosophie (2016), 128

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai ... [more ▼]

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai mon attention sur certaines divergences significatives entre Reinach et Brentano. Après quelques réflexions introductives (§§ 1-2), j’examinerai plus exactement les questions suivantes : quels sont les motifs théoriques qui ont conduit Reinach à s’écarter de la théorie brentanienne du jugement (§§ 3-4) ? Et que retenir de ses analyses aujourd’hui (§§ 5-6) ? [less ▲]

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See detailEtude de cas: l'attentat au Musée juif de Bruxelles
Debras, François ULg

in Politique : Revue de Débats (2016), 93

L’attaque soudaine d’un homme qui fait irruption dans un lieu public et tue quatre individus est angoissante. Les catastrophes, les drames et les malheurs qui frappent la société sont porteurs de ... [more ▼]

L’attaque soudaine d’un homme qui fait irruption dans un lieu public et tue quatre individus est angoissante. Les catastrophes, les drames et les malheurs qui frappent la société sont porteurs de nombreuses questions : qui, comment, pourquoi, dans quel but,… ? Les théories du complot permettent de répondre à un besoin social, celui de comprendre. Le complot est d’autant plus attirant et convaincant qu’il apporte une réponse simple, globale et dépouillée de toute subtilité. [less ▲]

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See detailĐánh giá tiềm năng bã rượu làm thức ăn chăn nuôi lợn nông hộ tại ba tỉnh phía Bắc
Nguyen Cong, Oanh ULg; Pham Kim, Dang; Vu Dinh, Ton et al

in Journal of Science and Development (2016), 14(1), 79-86

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were ... [more ▼]

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were surveyed and 18 samples of rice distiller’s by-product were collected from 3 traditional alcohol villages belonging to 3 different provinces in the North of Viet Nam (Hai Duong, Hung Yen and Bac Giang). The study results showed that rice distillers’ by product was produced in large quantity and available the whole year round in households surveyed (8.266 kg DM/household/year). The majority of this by-product was used for pig production. The rice distiller’s by-product use in feed ration varied between 11- 40% DM and 11-50% DM for sows and fattening pigs, respectively. For the sows, this by-product used in diet gradually reduced from pregnancy to milking sows. For the fattening pigs, its by-product is used continuously from piglet to finishing stage. Rice distiller’s by-product was high in protein, NDF (% DM) and energy (28.18%, 29.93% and 4.866,67 kcal/kg, respectively) but low in dry matter (DM) (11.04%). The low pH value (3.19) and high lactic acid ratio (2.31 g/100 g sample) might help improve digestive health and prevent intestinal diseases. [less ▲]

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See detailEffect of coil orientation on strength-duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation
D'Ostilio, Kevin ULg; Goetz, Stefan; Hannah, Ricci et al

in Clinical Neurophysiology (2016), 1

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central ... [more ▼]

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central sulcus. Methods: Motor threshold and input–output curve, along with motor evoked potential (MEP) latencies, of first dorsal interosseus were determined at pulse widths of 30, 60, and 120 μs using a controllable pulse parameter (cTMS) device, with the coil oriented PA or AP. These were used to estimate the S-D time constant and we compared with data for responses evoked by cTMS of the ulnar nerve at the elbow. Results: The S-D time constant with PA was shorter than for AP stimulation (230.9 ± 97.2 vs. 294.2 ± 90.9 us; p<0.001). These values were similar to those calculated after stimulation of ulnar nerve (197 ± 47us). MEP latencies to AP, but not PA stimulation were affected by pulse width, showing longer latencies following short duration stimuli. Conclusion: PA and AP stimuli appear to activate the axons of neurons with different time constants. Short duration AP pulses are more selective than longer pulses in recruiting longer latency corticospinal output. [less ▲]

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See detailVaricella paediatric hospitalisations in Belgium: a 1-year national survey.
Blumental, Sophie; Sabbe, Martine; Lepage, Philippe et al

in Archives of disease in childhood (2016), 101(1), 16-22

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real ... [more ▼]

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. METHODS: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. RESULTS: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/10(5) person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/10(5) person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had >/=1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/552) received acyclovir. Incidence of complicated hospitalised cases was 19/10(5) person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/10(6) and fatality ratio 0.2% among our cohort. CONCLUSIONS: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Thrombose veineuse ovarienne gauche et extension à la veine rénale
JEAN, FLORENCE; CLAUDOT, A.; ISTACE, B. et al

in Revue Médicale de Liège (2016), 71(1), 17-21

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of ... [more ▼]

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of cases. The usual clinical features include abdominal pain, fever and leucocytosis. However, the diagnosis is often complicated by other non specific signs and symptoms. Ovarian vein thrombosis may cause sepsis, pulmonary thromboembolism, and thrombosis of the inferior vena cava and the renal vein. The diagnosis can be established by CT scan or nuclear magnetic resonance imaging, which has a high sensitivity and specificity. Treatment for the ovarian vein thrombosis includes antibiotics and anticoagulation. The complications can sometimes be surgically managed. Prompt diagnosis and treatment can decrease the morbidity and the mortality. Nowadays, the fatal issue is rare as the appropriate treatment is quickly instaured. [less ▲]

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See detailA numerical study of hypoelastic and hyperelastic large strain viscoplastic Perzyna type models
Careglio, Claudio; Canales Cardenas, Cristian ULg; García Garino, Carlos et al

in Acta Mechanica (2016)

For the case ofmetalswith large viscoplastic strains, it is necessary to define appropriate constitutive models in order to obtain reliable results from the simulations. In this paper, two large strain ... [more ▼]

For the case ofmetalswith large viscoplastic strains, it is necessary to define appropriate constitutive models in order to obtain reliable results from the simulations. In this paper, two large strain viscoplastic Perzyna type models are considered. The first constitutive model has been proposed by Ponthot, and the elastic response is based on hypoelasticity. In this case, the kinematics of the constitutive model is based on the additive decomposition of the rate deformation tensor. The second constitutive model has been proposed by García Garino et al., and the elastic response is based on hyperelasticity. In this case, the kinematics of the constitutive model is based on the multiplicative decomposition of the deformation gradient tensor. In both cases, the resultant numerical models have been implemented in updated Lagrangian formulation. In this work, global and local numerical results of the mechanical response of both constitutive models are analyzed and discussed. To this end, numerical experiments are performed and different parameters of the constitutive models are tested in order to study the sensitivity of the resultant algorithms. In particular, the evolution of the reaction forces, the effective plastic strain, the deformed shapes and the sensitivity of the numerical results to the finite element mesh discretization have been compared and analyzed. The obtained results show that both models have a very good agreement and represent very well the characteristic of the viscoplastic constitutive model. [less ▲]

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See detailPopulatieonderzoek naar de Hazelmuis in de Voerstreek
Verbeylen, Goedele; Mouton, Alice ULg; Driessens, Gerald et al

in De Levende Natuur (2016), (numero 1),

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation ... [more ▼]

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation and fragmentation the Flemish distribution area of this critically endangered species has been reduced to the eastern part of the municipality of Voeren, where it forms a cross-border population with the Dutch Hazel dormice. Since 2003 the Mammal Working Group of Natuurpunt studies the remaining Flemish population to find out more about population parameters, habitat use, the influence of habitat quality and management actions. In 2007 a standardised monitoring started by counting autumnal nests along fixed transects. In 2013 an intensive capture-mark-recapture study was set up based on nest box and nest tube checks and live-trapping on custom made hanging platforms; also a first test with radiocollars took place. The information gathered from the combination of all these methods will be used to validate the monitoring method and to formulate better protection measures. First results show that late summer and autumn should not be considered as the main reproduction period, at least not in an early year like 2014 when first young were already born at the beginning of May. Hazel dormice do not only cross significant barriers like the railway during dispersal, but also do this regularly during their nightly movements within their home range. Expansion of the population on a location with sufficient connectivity seems to be hampered by a too low population density resulting from insufficient habitat quality and (in this case) a high predation pressure by house cats. On the scale of the Meuse-Rhine Euregion, genetic analyses carried out by the University of Liège reveal four genetically isolated clusters, for which a vision to interconnect these was computed in the Interreg-project ‘Habitat Euregio’. [less ▲]

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See detailarchiDART: an R package for the automated computation of plant root architectural traits
Delory, Benjamin ULg; Baudson, Caroline ULg; Brostaux, Yves ULg et al

in Plant and Soil (2016), 398(1), 351-365

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software ... [more ▼]

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software packages have been developed. These tools offer complementary approaches to study RSAs and the use of the Root System Markup Language (RSML) to store RSA data makes the comparison of measurements obtained with different (semi-) automated root imaging platforms easier. The throughput of the data analysis process using exported RSA data, however, should benefit greatly from batch analysis in a generic data analysis environment (R software). Methods We developed an R package (archiDART) with five functions. It computes global RSA traits, root growth rates, root growth directions and trajectories, and lateral root distribution from DART-generated and/or RSML files. It also has specific plotting functions designed to visualise the dynamics of root system growth. Results The results demonstrated the ability of the package’s functions to compute relevant traits for three contrasted RSAs (Brachypodium distachyon [L.] P. Beauv., Hevea brasiliensis Müll. Arg. and Solanum lycopersicum L.). Conclusions This work extends the DART software package and other image analysis tools supporting the RSML format, enabling users to easily calculate a number of RSA traits in a generic data analysis environment. [less ▲]

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See detailDynamical thermalization in Bose-Hubbard systems
Schlagheck, Peter ULg; Shepelyansky, Dima L.

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016), 93

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions ... [more ▼]

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions induce dynamical thermalization in this isolated system. In this regime the individual many-body eigenstates are well described by the standard thermal Bose-Einstein distribution for well-defined values of the temperature and the chemical potential, which depend on the eigenstate under consideration. We show that the dynamical thermalization conjecture works well at both positive and negative temperatures. The relations to quantum chaos, quantum ergodicity, and the Åberg criterion are also discussed. [less ▲]

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See detailThe effects of a documentary film about schizophrenia on cognitive, affective and behavioural aspects of stigmatisation
Thonon, Bénédicte ULg; Pletinx, Amandine; Grandjean, Allison et al

in Journal of Behavior Therapy and Experimental Psychiatry (2016), 50

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to ... [more ▼]

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to develop interventions aiming to prevent, reduce or eliminate such stereotypes. The aim of this study was to evaluate the effects of a documentary film on schizophrenia on cognitive, affective and behavioural aspects of stigmatisation. Methods: Forty-nine participants were assessed on measures of stereotypes and social distance, and on the Model of Stereotype Content, which includes measures of stereotypes, emotional reactions and behavioural tendencies. Participants were randomly assigned into either a condition in which they viewed the documentary film (Film group), or into a control condition in which no intervention was conducted (Control group). Results: Only participants in the Film group revealed a significant decrease of negative stereotypes (Dangerousness and Unpredictability) and desired Social distance, and a significant increase in the perception of sociability in persons with schizophrenia. Limitations: Small sample size and its reduced generalizability are the main limitations in this study. Conclusions: These findings suggest that a documentary film promoting indirect contact with people diagnosed with schizophrenia is a promising tool to prevent and reduce stigmatisation regarding schizophrenia. [less ▲]

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See detailDeterminants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Cavalier, Etienne ULg et al

in Osteoporosis International (2016), 27

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 ... [more ▼]

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. Introduction The aim of this study is to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Methods General practitioners (GPs) having at least one patient in a nursing home in Liège, Belgium, were asked to complete the survey. Results A total of 119 GPs participated in the survey. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. The main reasons for prescribing vitamin D cited by GPs who do so systematically are as follows: because they believe nursing home residents are mostly deficient in vitamin D status (92.1 %), because they believe that vitamin D supplementation prevents osteoporotic fractures (77.8 %), and because vitamin D supplementation is recommended by various scientific societies (38.1 %). GPs who only prescribe vitamin D supplementation in some patients mainly do so following a diagnosis of osteoporosis (82.4 %), on the basis the 25(OH)D level (78.4 %), in the case of history of fracture (54.9 %) or after a recent fracture (43.4 %). Surprisingly, 16 physicians (31.4 %) only prescribe vitamin D when they think of it. Interestingly, while 40.7% of GPs always prescribe the same dose of vitamin D, the remaining 59.3 % prescribe a dose that will mainly depend on the results of the 25(OH)D level (94.0 %), the patient’s bone health (49.3 %), or history of fracture (43.3 %). Conclusions More than half of GPs systematically prescribe vitamin D to their patients living in nursing homes. The other GPs usually prescribe vitamin D following the result of the vitamin D status or after a diagnosis of osteoporosis. [less ▲]

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See detailEffects of Methylmercury on Harbour Seal Peripheral Blood Leucocytes In Vitro Studied by Electron Microscopy
Dupont, Aurélie; De Pauw-Gillet, Marie-Claire ULg; Schnitzler, Joseph ULg et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 133-142

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal ... [more ▼]

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal lymphocytes, ConA-stimulated peripheral blood leucocytes were exposed in vitro to sub-lethal concentrations of MeHgCl (0.2, 1 and 2 µM) for 72h, and then analysed for their viability and ultrastructure. After 72h of incubation, cells were counted with a propidium iodide staining technique, a metabolic MTS assay was performed, and cells exposed to 1 µM MeHgCl were observed by transmission electron microscopy (TEM). Alive cell numbers decreased with increased MeHgCl concentrations. In presence of ConA and 1µM of MeHgCl, TEM images revealed a higher frequency of apoptotic cells. Exposed cells displayed condensation of the chromatin at the nuclear membrane and mitochondrial damages. The results suggest that in vitro MeHgCl induced apoptosis in harbour seal lymphocytes through a mitochondrial pathway. [less ▲]

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See detailLater learning stages in procedural memory are impaired in children with Specific Language Impairment
Desmottes, Lise ULg; Meulemans, Thierry ULg; Maillart, Christelle ULg

in Research in Developmental Disabilities (2016)

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language ... [more ▼]

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language Impairment (SLI). Most studies investigating the PDH have used the sequence learning paradigm; however these studies have principally focused on initial sequence learning in a single practice session. Aims The present study sought to extend these investigations by assessing the consolidation stage and longer-term retention of implicit sequence-specific knowledge in 42 children with or without SLI. Methods and procedures Both groups of children completed a serial reaction time task and were tested 24 h and one week after practice. Outcomes and results Results showed that children with SLI succeeded as well as children with typical development (TD) in the early acquisition stage of the sequence learning task. However, as training blocks progressed, only TD children improved their sequence knowledge while children with SLI did not appear to evolve any more. Moreover, children with SLI showed a lack of the consolidation gains in sequence knowledge displayed by the TD children. Conclusions and implications Overall, these results were in line with the predictions of the PDH and suggest that later learning stages in procedural memory are impaired in SLI. [less ▲]

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