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See detailElectrical resistivity tomography to monitor enhanced biodegradation of hydrocarbons with Rhodococcus erythropolis T902.1 at a pilot scale
Masy, Thibaut ULg; Caterina, David; Tromme, Oliver et al

in Journal of Contaminant Hydrology (2016), 184

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of ... [more ▼]

Petroleum hydrocarbons (HC) represent the most widespread contaminants and in-situ bioremediation remains a competitive treatment in terms of cost and environmental concerns. However, the efficiency of such a technique (by biostimulation or bioaugmentation) strongly depends on the environment affected and is still difficult to predict a priori. In order to overcome these uncertainties, Electrical Resistivity Tomography (ERT) appears as a valuable non-invasive tool to detect soil heterogeneities and to monitor biodegradation. The main objective of this study was to isolate an electrical signal linked to an enhanced bacterial activity with ERT, in an aged HC-contaminated clayey loam soil. To achieve this, a pilot tank was built to mimic field conditions. Compared to a first insufficient biostimulation phase, bioaugmentation with Rhodococcus erythropolis T902.1 led to a HC depletion of almost 80% (6900 to 1600 ppm) in 3 months in the center of the contaminated zone, where pollutants were less bioavailable. In the meantime, lithological heterogeneities and microbial activities (growth and biosurfactant production) were successively discriminated by ERT images. In the future, this cost-effective technique should be more and more transferred to the field in order to monitor biodegradation processes and assist in selecting the most appropriate remediation technique. [less ▲]

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See detailDeterminants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Cavalier, Etienne ULg et al

in Osteoporosis International (2016), 27

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 ... [more ▼]

Abstract Summary A total of 119 GPs participated to a survey aimed to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. Introduction The aim of this study is to assess the profile and determinants of vitamin D supplementation prescription in nursing homes. Methods General practitioners (GPs) having at least one patient in a nursing home in Liège, Belgium, were asked to complete the survey. Results A total of 119 GPs participated in the survey. Among the respondent GPs, 65 (54.6 %) systematically prescribe vitamin D to their institutionalized patients and the 54 (45.4 %) others prescribe only sometimes. The main reasons for prescribing vitamin D cited by GPs who do so systematically are as follows: because they believe nursing home residents are mostly deficient in vitamin D status (92.1 %), because they believe that vitamin D supplementation prevents osteoporotic fractures (77.8 %), and because vitamin D supplementation is recommended by various scientific societies (38.1 %). GPs who only prescribe vitamin D supplementation in some patients mainly do so following a diagnosis of osteoporosis (82.4 %), on the basis the 25(OH)D level (78.4 %), in the case of history of fracture (54.9 %) or after a recent fracture (43.4 %). Surprisingly, 16 physicians (31.4 %) only prescribe vitamin D when they think of it. Interestingly, while 40.7% of GPs always prescribe the same dose of vitamin D, the remaining 59.3 % prescribe a dose that will mainly depend on the results of the 25(OH)D level (94.0 %), the patient’s bone health (49.3 %), or history of fracture (43.3 %). Conclusions More than half of GPs systematically prescribe vitamin D to their patients living in nursing homes. The other GPs usually prescribe vitamin D following the result of the vitamin D status or after a diagnosis of osteoporosis. [less ▲]

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See detailComment je traite... la sténose aortique asymptomatique
MEURICE, Caroline ULg; DULGHERU, Raluca Elena ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), (71), 6-10

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See detailEffect of coil orientation on strength-duration time constant and I-wave activation with controllable pulse parameter transcranial magnetic stimulation
D'Ostilio, Kevin ULg; Goetz, Stefan; Hannah, Ricci et al

in Clinical Neurophysiology (2016), 1

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central ... [more ▼]

Objective: To compare the strength-duration (S-D) time constants of motor cortex structures activated by current pulses oriented posterior-anterior (PA) or anterior-posterior (AP) across the central sulcus. Methods: Motor threshold and input–output curve, along with motor evoked potential (MEP) latencies, of first dorsal interosseus were determined at pulse widths of 30, 60, and 120 μs using a controllable pulse parameter (cTMS) device, with the coil oriented PA or AP. These were used to estimate the S-D time constant and we compared with data for responses evoked by cTMS of the ulnar nerve at the elbow. Results: The S-D time constant with PA was shorter than for AP stimulation (230.9 ± 97.2 vs. 294.2 ± 90.9 us; p<0.001). These values were similar to those calculated after stimulation of ulnar nerve (197 ± 47us). MEP latencies to AP, but not PA stimulation were affected by pulse width, showing longer latencies following short duration stimuli. Conclusion: PA and AP stimuli appear to activate the axons of neurons with different time constants. Short duration AP pulses are more selective than longer pulses in recruiting longer latency corticospinal output. [less ▲]

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See detailCharacterizing the morphology of suburban settlements: a method based on a semi-automatic classification of building clusters
de Smet, Fabian; Teller, Jacques ULg

in Landscape Research (2016), 41(1), 113-130

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of ... [more ▼]

Urban sprawl is transforming our landscapes and rural areas at a spectacular pace. Measuring the strength of the phenomenon and proposing dynamic ways to delineate suburban areas have been the object of much debate amongst scientists. The present article takes the view that, beyond measuring and delineating suburban areas, more efforts should be directed to qualifying the morphology of built settlements within these areas. Therefore it proposes a method based on a semi-automatic classification system of building clusters, designed to describe and interpret the phenomenon from a morphological perspective. This method is based on a combination of field surveys with numerical analyses of digital land cadastre maps. The application of this classification system to the suburban area around Liege reveals that, far from developing in a complete indifference of local conditions, contemporary suburban settlements are influenced by landscape structures inherited from the past. [less ▲]

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See detailGenetic diversity and population structure of the Eurosian otte (Lutra lutra) in France
Geboes, Anne-Laure ULg; Rosoux, René; Lemarchand, Charles et al

in Mammal Research (2016), 61(1),

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before ... [more ▼]

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before the recolonisation process, two main populations still remained along the Atlantic coast and in the Massif Central. To investigate the impact of this decline on the genetic diversity and structure of the French otter population, tissue samples of 144 otter carcasses from road kills that were found during 1992–2011 along the Atlantic coast and in the Massif Central were used. They were analysed using 10 microsatellites loci. Observed (Ho = 0.64) and expected heterozygosity (He = 0.62) were moderate, but consistent with results found in other European populations. The bottleneck test showed an excess of heterozygotes, providing evidence of a recent decline. There was evidence for weak but significant allelic frequencies divergence between otters from the Atlantic coast and those from the Massif Central (Fst=0.040, p<0.05), probably resulting from their isolation prior to the recolonisation process. As the French otter population has been expanding for several years, genetic intermixing is now occurring. Although this expansion has not yet genetically homogenised all populations, this is may be a matter a time. [less ▲]

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See detailL’infraction d’obstacle à la surveillance sous le spectre du droit au silence et du droit de ne pas s’auto-incriminer
Michiels, Olivier ULg; Falque, Géraldine ULg

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2016), (2006/1), 2-11

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne ... [more ▼]

L'article fait le point sur le contrôle de l’application des lois sociales par les inspecteurs sociaux et le délit d’obstacle à la surveillance envisagé sous l'angle du droit au silence et du droit de ne pas s'auto-incriminer. Il envisage encore la cohabitation entre le délit d'obstacle et le droit au silence sous l’angle de la jurisprudence de la Cour européenne des droits de l’homme et du droit interne. [less ▲]

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See detailPopulatieonderzoek naar de Hazelmuis in de Voerstreek
Verbeylen, Goedele; Mouton, Alice ULg; Driessens, Gerald et al

in De Levende Natuur (2016), (numero 1),

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation ... [more ▼]

The Hazel dormouse (Muscardinus avellanarius) is a habitat specialist that prefers dense shrub and tree vegetation and needs a high diversity of food plants on a limited area. Due to habitat degradation and fragmentation the Flemish distribution area of this critically endangered species has been reduced to the eastern part of the municipality of Voeren, where it forms a cross-border population with the Dutch Hazel dormice. Since 2003 the Mammal Working Group of Natuurpunt studies the remaining Flemish population to find out more about population parameters, habitat use, the influence of habitat quality and management actions. In 2007 a standardised monitoring started by counting autumnal nests along fixed transects. In 2013 an intensive capture-mark-recapture study was set up based on nest box and nest tube checks and live-trapping on custom made hanging platforms; also a first test with radiocollars took place. The information gathered from the combination of all these methods will be used to validate the monitoring method and to formulate better protection measures. First results show that late summer and autumn should not be considered as the main reproduction period, at least not in an early year like 2014 when first young were already born at the beginning of May. Hazel dormice do not only cross significant barriers like the railway during dispersal, but also do this regularly during their nightly movements within their home range. Expansion of the population on a location with sufficient connectivity seems to be hampered by a too low population density resulting from insufficient habitat quality and (in this case) a high predation pressure by house cats. On the scale of the Meuse-Rhine Euregion, genetic analyses carried out by the University of Liège reveal four genetically isolated clusters, for which a vision to interconnect these was computed in the Interreg-project ‘Habitat Euregio’. [less ▲]

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See detailCost-effectiveness of personalized supplementation with vitamin D-rich dairy products in the prevention of osteoporotic fractures
Ethgen, Olivier ULg; Hiligsmann, Mickaël; Burlet, Nansa et al

in Osteoporosis International (2016), 27

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of ... [more ▼]

Summary: Titrated supplementations with vitamin D-fortified yogurt, based on spontaneous calcium and vitamin D intakes, can be cost-effective in postmenopausal women with or without increased risk of osteoporotic fractures. Introduction: The objective of this study is to assess the costeffectiveness of the vitamin D-fortified yogurt given to women with and without an increased risk of osteoporotic fracture. Methods: Avalidated cost-effectiveness microsimulation Markov model of osteoporosis management was used. Three personalized supplementation scenarios to reflect the Ca/Vit D needs taking into account the well-known variations in dietary habits and a possible pharmacological supplementation in Ca/ Vit D, given above or in combination with anti-osteoporosis medications: one yogurt per day, i.e., 400 mg of Ca+200 IU of Vit D (scenario 1 U), two yogurts per day, i.e., 800 mg of Ca+ 400 IU of Vit D (scenario 2 U), or three yogurts per day, i.e., 1, 200 mg of Ca+600 IU of Vit D (scenario 3 U). Results: One yogurt is cost-effective in the general population above the age of 70 years and in all age groups in women with low bone mineral density (BMD) or prevalent vertebral fracture (PVF). The daily intake of two yogurts is cost-effective above 80 years in the general population and above 70 years in the two groups of women at increased risk of fractures. However, an intake of three yogurts per day is only cost-effective above 80 years old in the general population, as well as in women with low BMD or PVF. Conclusions: Our study is the first economic analysis supporting the cost-effectiveness of dairy products, fortified with vitamin D, in the armamentarium against osteoporotic fractures. [less ▲]

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See detailarchiDART: an R package for the automated computation of plant root architectural traits
Delory, Benjamin ULg; Baudson, Caroline ULg; Brostaux, Yves ULg et al

in Plant and Soil (2016), 398(1), 351-365

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software ... [more ▼]

Background and Aims In order to analyse root system architectures (RSAs) from captured images, a variety of manual (e.g. Data Analysis of Root Tracings, DART), semi-automated and fully automated software packages have been developed. These tools offer complementary approaches to study RSAs and the use of the Root System Markup Language (RSML) to store RSA data makes the comparison of measurements obtained with different (semi-) automated root imaging platforms easier. The throughput of the data analysis process using exported RSA data, however, should benefit greatly from batch analysis in a generic data analysis environment (R software). Methods We developed an R package (archiDART) with five functions. It computes global RSA traits, root growth rates, root growth directions and trajectories, and lateral root distribution from DART-generated and/or RSML files. It also has specific plotting functions designed to visualise the dynamics of root system growth. Results The results demonstrated the ability of the package’s functions to compute relevant traits for three contrasted RSAs (Brachypodium distachyon [L.] P. Beauv., Hevea brasiliensis Müll. Arg. and Solanum lycopersicum L.). Conclusions This work extends the DART software package and other image analysis tools supporting the RSML format, enabling users to easily calculate a number of RSA traits in a generic data analysis environment. [less ▲]

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See detailPre-employement examination for low back risk in workers exposesd to manual handling of loads : French guidelines
PETIT, Audrey; ROUSSEAU, Sandrine; HUEZ, Jean-François et al

in International Archives of Occupational and Environmental Health (2016), 89

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See detailNos différences, une richesse
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2016), 59

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See detailGender differences in variability and extreme scores in an international context
Baye, Ariane ULg; Monseur, Christian ULg

in Large-scale Assessments in Education (2016), 4(1),

This study examines gender differences in the variability of student performance in reading, mathematics and science. Twelve databases from IEA and PISA were used to analyze gender differences within an ... [more ▼]

This study examines gender differences in the variability of student performance in reading, mathematics and science. Twelve databases from IEA and PISA were used to analyze gender differences within an international perspective from 1995 to 2015. Effect sizes and variance ratios were computed. The main results are as follows. (1) Gender differences vary by content area, students’ educational levels, and students’ proficiency levels. The gender differences at the extreme tails of the distribution are often more substantial than the gender differences at the mean. (2) Exploring the extreme tails of the distributions shows that the situation of the weakest males in reading is a real matter of concern. In mathematics and science, males are more frequently among the highest performing students. (3) The “greater male variability hypothesis” is confirmed. [less ▲]

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See detailVaricella paediatric hospitalisations in Belgium: a 1-year national survey.
Blumental, Sophie; Sabbe, Martine; Lepage, Philippe et al

in Archives of disease in childhood (2016), 101(1), 16-22

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real ... [more ▼]

BACKGROUND: Varicella universal vaccination (UV) has been implemented in many countries for several years. Nevertheless, varicella UV remains debated in Europe and few data are available on the real burden of infection. We assessed the burden of varicella in Belgium through analysis of hospitalised cases during a 1-year period. METHODS: Data on children admitted to hospital with varicella were collected through a national network from November 2011 to October 2012. Inclusion criteria were either acute varicella or related complications up to 3 weeks after the rash. RESULTS: Participation of 101 hospitals was obtained, covering 97.7% of the total paediatric beds in Belgium. 552 children were included with a median age of 2.1 years. Incidence of paediatric varicella hospitalisations reached 29.5/10(5) person-years, with the highest impact among those 0-4 years old (global incidence and odds of hospitalisation: 79/10(5) person-years and 1.6/100 varicella cases, respectively). Only 14% (79/552) of the cohort had an underlying chronic condition. 65% (357/552) of children had >/=1 complication justifying their admission, 49% were bacterial superinfections and 10% neurological disorders. Only a quarter of children (141/552) received acyclovir. Incidence of complicated hospitalised cases was 19/10(5) person-years. Paediatric intensive care unit admission and surgery were required in 4% and 3% of hospitalised cases, respectively. Mortality among Belgian paediatric population was 0.5/10(6) and fatality ratio 0.2% among our cohort. CONCLUSIONS: Varicella demonstrated a substantial burden of disease in Belgian children, especially among the youngest. Our thorough nationwide study, run in a country without varicella UV, offers data to support varicella UV in Belgium. [less ▲]

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See detailL'observation foncière en France, à Bruxelles et en Flandre
Hendrickx, Sébastien ULg; Sarciat, Jordane ULg; Halleux, Jean-Marie ULg

in Notes de recherche - Conférence Permanente du Développement Territorial Région Wallonne (2016), 64

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques ... [more ▼]

Depuis quelques années, un intérêt accru se développe pour l’observation des marchés fonciers et la recherche de gisements fonciers, indispensables à une mise en œuvre efficace des politiques d’aménagement du territoire et des politiques sectorielles. La note de recherche n° 64 s’intéresse aux pratiques d’observation dans les territoires adjacents à la Wallonie et plus exactement aux outils développés en France, en Flandre et en Région de Bruxelles-Capitale. L’analyse de ces différents cas a mis en exergue l'avance évidente de nos voisins sur ces problématiques et permet d'apprécier l’utilité d’une connaissance territoriale accrue pour l’élaboration des stratégies de développement territorial et pour la prise de décision politique. Elle aboutit à diverses recommandations relatives à l’amélioration du système d’informations foncières et des politiques foncières en Wallonie. [less ▲]

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See detailOverview of the Analytical Lifecycle of Supercritical Fluid Chromatography Methods
Andri, Bertyl ULg; Dispas, Amandine ULg; Marini Djang'Eing'A, Roland ULg et al

in American Journal of Analytical Chemistry (2016), 7

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See detailĐánh giá tiềm năng bã rượu làm thức ăn chăn nuôi lợn nông hộ tại ba tỉnh phía Bắc
Nguyen Cong, Oanh ULg; Pham Kim, Dang; Vu Dinh, Ton et al

in Journal of Science and Development (2016), 14(1), 79-86

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were ... [more ▼]

In order to evaluate the potential of the rice distiller’s by-product for use as feed, the chemical composition and nutritive value, and its utilisation in pig production, 120 rice alcohol producers were surveyed and 18 samples of rice distiller’s by-product were collected from 3 traditional alcohol villages belonging to 3 different provinces in the North of Viet Nam (Hai Duong, Hung Yen and Bac Giang). The study results showed that rice distillers’ by product was produced in large quantity and available the whole year round in households surveyed (8.266 kg DM/household/year). The majority of this by-product was used for pig production. The rice distiller’s by-product use in feed ration varied between 11- 40% DM and 11-50% DM for sows and fattening pigs, respectively. For the sows, this by-product used in diet gradually reduced from pregnancy to milking sows. For the fattening pigs, its by-product is used continuously from piglet to finishing stage. Rice distiller’s by-product was high in protein, NDF (% DM) and energy (28.18%, 29.93% and 4.866,67 kcal/kg, respectively) but low in dry matter (DM) (11.04%). The low pH value (3.19) and high lactic acid ratio (2.31 g/100 g sample) might help improve digestive health and prevent intestinal diseases. [less ▲]

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See detailLater learning stages in procedural memory are impaired in children with Specific Language Impairment
Desmottes, Lise ULg; Meulemans, Thierry ULg; Maillart, Christelle ULg

in Research in Developmental Disabilities (2016)

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language ... [more ▼]

Background According to the Procedural Deficit Hypothesis (PDH), difficulties in the procedural memory system may contribute to the language difficulties encountered by children with Specific Language Impairment (SLI). Most studies investigating the PDH have used the sequence learning paradigm; however these studies have principally focused on initial sequence learning in a single practice session. Aims The present study sought to extend these investigations by assessing the consolidation stage and longer-term retention of implicit sequence-specific knowledge in 42 children with or without SLI. Methods and procedures Both groups of children completed a serial reaction time task and were tested 24 h and one week after practice. Outcomes and results Results showed that children with SLI succeeded as well as children with typical development (TD) in the early acquisition stage of the sequence learning task. However, as training blocks progressed, only TD children improved their sequence knowledge while children with SLI did not appear to evolve any more. Moreover, children with SLI showed a lack of the consolidation gains in sequence knowledge displayed by the TD children. Conclusions and implications Overall, these results were in line with the predictions of the PDH and suggest that later learning stages in procedural memory are impaired in SLI. [less ▲]

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See detailThe effects of a documentary film about schizophrenia on cognitive, affective and behavioural aspects of stigmatisation
Thonon, Bénédicte ULg; Pletinx, Amandine; Grandjean, Allison et al

in Journal of Behavior Therapy and Experimental Psychiatry (2016), 50

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to ... [more ▼]

Background and Objectives: Stereotypes about schizophrenia may lead to prejudicial attitudes and discrimination with debilitating effects on people diagnosed with schizophrenia. There is thus a need to develop interventions aiming to prevent, reduce or eliminate such stereotypes. The aim of this study was to evaluate the effects of a documentary film on schizophrenia on cognitive, affective and behavioural aspects of stigmatisation. Methods: Forty-nine participants were assessed on measures of stereotypes and social distance, and on the Model of Stereotype Content, which includes measures of stereotypes, emotional reactions and behavioural tendencies. Participants were randomly assigned into either a condition in which they viewed the documentary film (Film group), or into a control condition in which no intervention was conducted (Control group). Results: Only participants in the Film group revealed a significant decrease of negative stereotypes (Dangerousness and Unpredictability) and desired Social distance, and a significant increase in the perception of sociability in persons with schizophrenia. Limitations: Small sample size and its reduced generalizability are the main limitations in this study. Conclusions: These findings suggest that a documentary film promoting indirect contact with people diagnosed with schizophrenia is a promising tool to prevent and reduce stigmatisation regarding schizophrenia. [less ▲]

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See detailDynamical thermalization in Bose-Hubbard systems
Schlagheck, Peter ULg; Shepelyansky, Dima L.

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016), 93

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions ... [more ▼]

We numerically study a Bose-Hubbard ring of finite size with disorder containing a finite number of bosons that are subject to an on-site two-body interaction. Our results show that moderate interactions induce dynamical thermalization in this isolated system. In this regime the individual many-body eigenstates are well described by the standard thermal Bose-Einstein distribution for well-defined values of the temperature and the chemical potential, which depend on the eigenstate under consideration. We show that the dynamical thermalization conjecture works well at both positive and negative temperatures. The relations to quantum chaos, quantum ergodicity, and the Åberg criterion are also discussed. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Thrombose veineuse ovarienne gauche et extension à la veine rénale
JEAN, FLORENCE; CLAUDOT, A.; ISTACE, B. et al

in Revue Médicale de Liège (2016), 71(1), 17-21

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of ... [more ▼]

Ovarian vein thrombosis is a rare, but potentially serious postpartum complication. In 80 % of the cases, it occurs on the right side and in less than 6 % on the left side; it is bilateral in 14 % of cases. The usual clinical features include abdominal pain, fever and leucocytosis. However, the diagnosis is often complicated by other non specific signs and symptoms. Ovarian vein thrombosis may cause sepsis, pulmonary thromboembolism, and thrombosis of the inferior vena cava and the renal vein. The diagnosis can be established by CT scan or nuclear magnetic resonance imaging, which has a high sensitivity and specificity. Treatment for the ovarian vein thrombosis includes antibiotics and anticoagulation. The complications can sometimes be surgically managed. Prompt diagnosis and treatment can decrease the morbidity and the mortality. Nowadays, the fatal issue is rare as the appropriate treatment is quickly instaured. [less ▲]

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See detailEffects of Methylmercury on Harbour Seal Peripheral Blood Leucocytes In Vitro Studied by Electron Microscopy
Dupont, Aurélie; De Pauw-Gillet, Marie-Claire ULg; Schnitzler, Joseph ULg et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 133-142

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal ... [more ▼]

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal lymphocytes, ConA-stimulated peripheral blood leucocytes were exposed in vitro to sub-lethal concentrations of MeHgCl (0.2, 1 and 2 µM) for 72h, and then analysed for their viability and ultrastructure. After 72h of incubation, cells were counted with a propidium iodide staining technique, a metabolic MTS assay was performed, and cells exposed to 1 µM MeHgCl were observed by transmission electron microscopy (TEM). Alive cell numbers decreased with increased MeHgCl concentrations. In presence of ConA and 1µM of MeHgCl, TEM images revealed a higher frequency of apoptotic cells. Exposed cells displayed condensation of the chromatin at the nuclear membrane and mitochondrial damages. The results suggest that in vitro MeHgCl induced apoptosis in harbour seal lymphocytes through a mitochondrial pathway. [less ▲]

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See detailL'intentionnalité cognitive et ses modes. Reinach critique de Brentano
Dewalque, Arnaud ULg

in Philosophie (2016), 128

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai ... [more ▼]

Dans cet article, je suggère que la théorie reinachienne du jugement peut être vue comme une contribution à une théorie générale de l’intentionnalité cognitive et de ses modes. À cette fin, je focaliserai mon attention sur certaines divergences significatives entre Reinach et Brentano. Après quelques réflexions introductives (§§ 1-2), j’examinerai plus exactement les questions suivantes : quels sont les motifs théoriques qui ont conduit Reinach à s’écarter de la théorie brentanienne du jugement (§§ 3-4) ? Et que retenir de ses analyses aujourd’hui (§§ 5-6) ? [less ▲]

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See detailXenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects?
Lehnert, Kristina; Ronnenberg, Katrin; Weijs, Liesbeth et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 106-120

Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which ... [more ▼]

Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect the immune-system and have been reported e.g. to increase susceptibility to viral infections in seals. Biomarkers of the xenobiotic metabolism, cytokines and heat-shock-protein as cell mediators of the immune-system were established to evaluate the impact of environmental stressors on harbor seals. Harbor seals (n=54) were captured on sandbanks in the North Sea during 2009 to 2012. Medicals including hematology were performed, RNAlater blood samples were taken and analyzed using quantitative Polymerase Chain Reaction. Normalized transcript copy numbers were correlated to hematology and POP concentration in blood, and trace metals in blood and fur. [less ▲]

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See detailDoes the Budyko curve reflect a maximum power state of hydrological systems? A backward analysis
Westhoff, Martijn ULg; Zehe, Erwin; Archambeau, Pierre ULg et al

in Hydrology and Earth System Sciences (2016), 20

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we ... [more ▼]

Almost all catchments plot within a small envelope around the Budyko curve. This apparent behaviour suggests that organizing principles may play a role in the evolution of catchments. In this paper we applied the thermodynamic principle of maximum power as the organizing principle. In a top-down approach we derived mathematical formulations of the relation between relative wetness and gradients driving runoff and evaporation for a simple one-box model. We did this in an inverse manner such that when the conductances are optimized with the maximum power principle, the steady state behaviour of the model leads exactly to a point on the asymptotes of the Budyko curve. Subsequently, we added dynamics in forcing and actual evaporations, causing the Budyko curve to deviate from the asymptotes. Despite the simplicity of the model, catchment observations compare reasonably well with the Budyko curves subject to observed dynamics in rainfall and actual evaporation. Thus by constraining the model with the asymptotes of the Budyko curve we were able to derive more realistic values of the aridity and evaporation index without any calibration parameter. Future work should focus on better representing the boundary conditions of real catchments and eventually adding more complexity to the model. [less ▲]

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See detailCompte rendu de l’ouvrage de VANACKER Daniël (éd.), Journal d’une bourgeoise, 1914-1918 : Marguerite Giron
Bechet, Christophe ULg

in Bulletin d'Information de l'Association Belge d'Histoire Contemporaine = Mededelingenblad van de Belgische Vereniging voor Nieuwste Geschiedenis (2016), XXXVIII(1),

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See detailHigh-urgency kidney transplantation in the Eurotransplant Kidney Allocation System: success or waste of organs? The Eurotransplant 15-year all-centre survey.
Assfalg, Volker; Huser, Norbert; van Meel, Marieke et al

in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2016)

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement ... [more ▼]

BACKGROUND: In the Eurotransplant Kidney Allocation System (ETKAS), transplant candidates can be considered for high-urgency (HU) status in case of life-threatening inability to undergo renal replacement therapy. Data on the outcomes of HU transplantation are sparse and the benefit is controversial. METHODS: We systematically analysed data from 898 ET HU kidney transplant recipients from 61 transplant centres between 1996 and 2010 and investigated the 5-year patient and graft outcomes and differences between relevant subgroups. RESULTS: Kidney recipients with an HU status were younger (median 43 versus 55 years) and spent less time on the waiting list compared with non-HU recipients (34 versus 54 months). They received grafts with significantly more mismatches (mean 3.79 versus 2.42; P < 0.001) and the percentage of retransplantations was remarkably higher (37.5 versus 16.7%). Patient survival (P = 0.0053) and death with a functioning graft (DwFG; P < 0.0001) after HU transplantation were significantly worse than in non-HU recipients, whereas graft outcome was comparable (P = 0.094). Analysis according to the different HU indications revealed that recipients listed HU because of an imminent lack of access for dialysis had a significantly worse patient survival (P = 0.0053) and DwFG (P = 0.0462) compared with recipients with psychological problems and suicidality because of dialysis. In addition, retransplantation had a negative impact on patient and graft outcome. CONCLUSIONS: Facing organ shortages, increasing wait times and considerable mortality on dialysis, we question the current policy of HU allocation and propose more restrictive criteria with regard to individuals with vascular complications or repeated retransplantations in order to support patients on the non-HU waiting list with a much better long-term prognosis. [less ▲]

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See detailReconstruction of the Evolutionary History and Dispersal of Usutu Virus, a Neglected Emerging Arbovirus in Europe and Africa.
Engel, Dimitri; Jost, Hanna; Wink, Michael et al

in mBio (2016), 7(1),

Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds and sporadic infection in humans. The dynamics of USUV spread and ... [more ▼]

Usutu virus (USUV), one of the most neglected Old World encephalitic flaviviruses, causes epizootics among wild and captive birds and sporadic infection in humans. The dynamics of USUV spread and evolution in its natural hosts are unknown. Here, we present the phylogeny and evolutionary history of all available USUV strains, including 77 newly sequenced complete genomes from a variety of host species at a temporal and spatial scaled resolution. The results showed that USUV can be classified into six distinct lineages and that the most recent common ancestor of the recent European epizootics emerged in Africa at least 500 years ago. We demonstrated that USUV was introduced regularly from Africa into Europe in the last 50 years, and the genetic diversity of European lineages is shaped primarily by in situ evolution, while the African lineages have been driven by extensive gene flow. Most of the amino acid changes are deleterious polymorphisms removed by purifying selection, with adaptive evolution restricted to the NS5 gene and several others evolving under episodic directional selection, indicating that the ecological or immunological factors were mostly the key determinants of USUV dispersal and outbreaks. Host-specific mutations have been detected, while the host transition analysis identified mosquitoes as the most likely origin of the common ancestor and birds as the source of the recent European USUV lineages. Our results suggest that the major migratory bird flyways could predict the continental and intercontinental dispersal patterns of USUV and that migratory birds might act as potential long-distance dispersal vehicles. IMPORTANCE: Usutu virus (USUV), a mosquito-borne flavivirus of the Japanese encephalitis virus antigenic group, caused massive bird die-offs, mostly in Europe. There is increasing evidence that USUV appears to be pathogenic for humans, becoming a potential public health problem. The emergence of USUV in Europe allows us to understand how an arbovirus spreads, adapts, and evolves in a naive environment. Thus, understanding the epidemiological and evolutionary processes that contribute to the emergence, maintenance, and further spread of viral diseases is the sine qua non to develop and implement surveillance strategies for their control. In this work, we performed an expansive phylogeographic and evolutionary analysis of USUV using all published sequences and those generated during this study. Subsequently, we described the genetic traits, reconstructed the potential pattern of geographic spread between continents/countries of the identified viral lineages and the drivers of viral migration, and traced the origin of outbreaks and transition events between different hosts. [less ▲]

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See detailGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa et al

in Autophagy (2016), 12(1), 1-222

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See detailBi-objective Road and Pipe Network Design for Crude Oil Transport in the Sfax Region in Tunisia
Belaid, Emna ULg; Limbourg, Sabine ULg; Mostert, Martine ULg et al

in Procedia Engineering (2016), 142

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the ... [more ▼]

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the different oil fields with the port of La Skhirra. In the determination of the minimum spanning trees, two objectives are taken into account, i.e. accident risk and construction costs. By using an improved ɛ-constraint resolution technique, the Pareto optimal combinations of risk and cost are found. Results indicate that the network solutions by pipe outperform the solutions by road. When the minimum spanning trees for the two extremes on the Pareto curves, i.e. the cost minimum and risk minimum, are compared, one could note considerable differences in the links that form the MST. This implies that policy makers have an important role in deliberating between costs and risks. [less ▲]

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See detailLa couverture santé universelle dans les pays à revenus faibles et intermédiaires : analyses économiques
Paul, Elisabeth ULg; Bodson, Oriane ULg; Ridde, Valéry et al

in Reflets et Perspectives de la Vie Economique (2016), 1

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé ... [more ▼]

Les pays à revenu faible et intermédiaire sont confrontés à des besoins de financement élevés pour assurer une couverture santé universelle (CSU) permettant à chacun d'avoir accès à des services de santé de qualité sans encourir de difficultés financières. Cet article tente de montrer comment l'analyse économique peut être mobilisée pour identifier des stratégies utiles pour tendre vers la CSU. Trois axes complémentaires où l'analyse économique a une plus-value sont présentés : i) la mobilisation des ressources et l'équité verticale ; ii) l'amélioration de l'efficacité dans l'allocation des ressources et l'équité horizontale ; iii) la gestion opérationnelle des ressources, en particulier à travers le financement basé sur les résultats (efficience). Pour chacun, nous présentons un bref état des lieux de l'état des connaissances et évoquons quelques perspectives de recherche. [less ▲]

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See detailDisplacement of an Electrically Charged Drop on a Vibrating Bath
Brandenbourger, Martin ULg; Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in Physical Review Letters (2016), 116

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See detailChemoautotrophy and anoxygenic photosynthesis within the water column of a large meromictic tropical lake (Lake Kivu, East Africa)
Morana, Cédric; Roland, Fleur ULg; Crowe, Sean A. et al

in Limnology and Oceanography (2016)

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to ... [more ▼]

We quantified chemoautotrophic and anoxygenic photosynthetic microbial production in the water column of Lake Kivu, a permanently stratified tropical lake situated amidst volcanic activity, and aimed to identify the microorganisms involved in these processes through the analysis of their phospholipid fatty acid (PLFA) content and stable isotope (13C) labelling of PLFA in a set of incubation experiments. Data demonstrate the existence of a biogeochemically active chemoautotrophic bacterial community in the redoxcline of Lake Kivu (50–70 m). PLFA data indicate that the bacterial communities are structured vertically in the water column, with a large dissimilarity between the oxic and anoxic waters. Maximum volumetric dark CO2 fixation rates measured in Lake Kivu were in the same range as values reported from H2S-rich marine redoxclines, such as the Black and Baltic Seas, and the Cariaco Basin. Similarly, maximal chemoautotrophic activities in Lake Kivu were observed in sulfidic waters, just below the oxycline. Anoxygenic photosynthetic production was never observed in the main basin of Lake Kivu. However, anoxygenic phototrophs largely dominated CO2 fixation in the illuminated redoxcline of Kabuno Bay, a shallower ferruginous sub-basin. Overall, this study supports the idea that chemoautotrophs and/or anoxygenic photoautotrophs might play an important role in the flow of carbon and energy in permanently stratified tropical ecosystems. In Lake Kivu, these processes significantly contribute to organic matter biosynthesis and exert an indirect control on oxygenic photoautotrophs by shortcircuiting the vertical transport of nutrients to the illuminated and oxygenated surface waters. [less ▲]

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See detailExistence of two groups of Staphylococcus aureus strains isolated from bovine mastitis based on biofilm formation, intracellular survival, capsular profile and agr-typing.
Bardiau, Marjorie ULg; Caplin, Jonathan; Detilleux, Johann ULg et al

in Veterinary microbiology (2016), 185

Staphylococcus (S.) aureus is recognised worldwide as an important pathogen causing contagious acute and chronic bovine mastitis. Chronic mastitis account for a significant part of all bovine cases and ... [more ▼]

Staphylococcus (S.) aureus is recognised worldwide as an important pathogen causing contagious acute and chronic bovine mastitis. Chronic mastitis account for a significant part of all bovine cases and represent an important economic problem for dairy producers. Several properties (biofilm formation, intracellular survival, capsular expression and group agr) are thought to be associated with this chronic status. In a previous study, we found the existence of two groups of strains based on the association of these features. The aim of the present work was to confirm on a large international and non-related collection of strains the existence of these clusters and to associate them with case history records. In addition, the genomes of eight strains were sequenced to study the genomic differences between strains of each cluster. The results confirmed the existence of both groups based on capsular typing, intracellular survival and agr-typing: strains cap8-positive, belonging to agr group II, showing a low invasion rate and strains cap5-positive, belonging to agr group I, showing a high invasion rate. None of the two clusters were associated with the chronic status of the cow. When comparing the genomes of strains belonging to both clusters, the genes specific to the group "cap5-agrI" would suggest that these strains are better adapted to live in hostile environment. The existence of these two groups is highly important as they may represent two clusters that are adapted differently to the host and/or the surrounding environment. [less ▲]

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See detailCompte-rendu de l'ouvrage "Wirklichkeit und Wahrnehmung. Neue Perspektiven auf Theodor Storm"
Leyh, Valérie ULg

in Schriften der Theodor-Storm-Gesellschaft (2016), 65

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See detailUnveiling Network and Service Performance Degradation in the Wild with mPlane
Casas, Pedro; Fiadino, Pierdomenico; Wassermann, Sarah ULg et al

in IEEE Communications Magazine - Network Testing Series (2016)

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity ... [more ▼]

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity. However, its distributed nature leads to operational brittleness and difficulty in identifying the root causes of performance degradation. In such a context, network measurements are a fundamental pillar to shed light and to unveil design and implementation defects. To tackle this fragmentation and visibility problem, we have recently conceived mPlane, a distributed measurement platform which runs, collects and analyses traffic measurements to study the operation and functioning of the Internet. In this paper, we show the potentiality of the mPlane approach to unveil network and service degradation issues in live, operational networks, involving both fixed-line and cellular networks. In particular, we combine active and passive measurements to troubleshoot problems in end-customer Internet access connections, or to automatically detect and diagnose anomalies in Internet-scale services (e.g., YouTube) which impact a large number of end-users. [less ▲]

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See detailComparative virucidal efficacy of seven disinfectants against murine norovirus and feline calicivirus, surrogates of human norovirus
Zonta, William ULg; Mauroy, Axel ULg; Farnir, Frédéric ULg et al

in Food and Environmental Virology (2016)

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge ... [more ▼]

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge of an efficient disinfection for both hands and food contact surfaces is helpful for the food sector and provides precious information for public health. The aim of this study was to evaluate the effect of seven disinfectants belonging to different groups of biocides (alcohol, halogen, oxidizing agents, quaternary ammonium compounds, aldehyde and biguanide) on infectious viral titre and on genomic copy number. Due to the absence of a cell culture system for HuNoV, two HuNoV surrogates such as murine norovirus (MNV) and feline calicivirus (FCV), were used and the tests were performed in suspension, on gloves and on stainless steel discs. When, as criteria of efficacy, a log reduction > 3 of the infectious viral titre on both surrogates and in the three tests is used, the most efficacious disinfectants in this study appear to be biocidal products B, C and D, representing the halogens, the oxidizing agents group and a mix of QAC, alcohol and aldehyde, respectively. In addition, these three disinfectants also elicited a significant effect on genomic copy number for both surrogate viruses and in all three tests. The results of this study demonstrate that a halogen compound, oxidizing agents and a mix of QAC, alcohol and aldehyde are advisable for HuNoV disinfection of either potentially contaminated surfaces or materials in contact with foodstuffs. [less ▲]

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See detailL'impôt sur les revenus des salariés et l'extranéité (2e partie)
Docclo, Caroline ULg

in Journal des Tribunaux du Travail (2016)

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See detailInvestigational insulin secretagogues for type 2 diabetes.
SCHEEN, André ULg

in Expert opinion on investigational drugs (2016), 25(4), 405-22

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent ... [more ▼]

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent of glucose and cause hypoglycemia. Despite the advantages offered by incretin-based therapies, there is still a medical need for developing new insulin secretagogues for treating T2D. AREA COVERED: This article discusses: the new advances in the field of incretin-based therapies, glucokinase (GK) activators, free fatty acid receptor (FFAR) or G protein-coupled receptor (GPR) agonists (GPR40, GPR119, GPR120), imeglimin and some other insulin secretagogues with diverse mechanisms of action still in preclinical development. EXPERT OPINION: New insulin secretagogues should offer major advantages over sulfonylureas and gliptins. The challenge is to avoid uncontrolled insulin secretion and minimize the risk of hypoglycemia, to protect cells from progressive loss of mass and function for a better durability of glucose control, and to offer a good safety profile. Numerous approaches are in development. However, it is too early to decide whether one new pharmacological class will emerge as a clinically useful insulin secretagogue in the near feature. [less ▲]

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See detailSources of dissolved silica to the fjords of northern Patagonia (44–48°S): the importance of volcanic ash soil distribution and weathering
Vandekerkhove, Elke; Bertrand, Sébastien; Reid, Brian et al

in Earth Surface Processes and Landforms (2016), 41(4), 499-512

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See detailEfficacy and safety of hyaluronic acid in the management of osteoarthritis : Evidence from real-life setting trials and surveys.
Maheu, E.; Rannou, F.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 28-33

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends intra-articular (IA) hyaluronic acid (HA) for management of knee osteoarthritis (OA) as second-line treatment in patients who remain symptomatic despite use of non-steroidal anti-inflammatory drugs (NSAIDs). This recommendation is based upon accumulating evidence that IA HA provides a significant benefit in knee OA. There is good evidence that IA HA injections reduce pain and increase function in knee OA, and the benefits are long-lasting as compared with IA corticosteroids. Evidence from real-life studies of repeat courses of IA HA demonstrates an improvement in pain or function lasting up to 40 months (12 months after the last injection cycle), a reduction in use of concomitant analgesia by up to 50%, and suggests that there may be a delay in the need for total knee replacement (TKR) of around 2 years. The clinical benefit of IA HA on knee OA may be 2-fold: (i) mechanical viscosupplementation of the joint (allowing lubrication and shock absorption) and (ii) the re-establishment of joint homeostasis through induction of endogenous HA production, which continues long after the exogenous injection has left the joint.The magnitude of the clinical effect may be different for different HA products, but this has not been proven so far and requires further investigation. IA HA injections are generally considered to be safe,although a slightly higher number of cases of local reactions and post-injection non-septic arthritis has been reported with high molecular weight cross-linked HAs. The use of IA HA in knee OA patients with mild–moderate disease, and for more severe patients wishing to delay TKR surgery,is recommended by the ESCEO taskforce. Further investigation into the OA patient types most likely to benefit from IA HA is warranted. Viscosupplementation with IA HA is a safe and effective component of the multi-modal management of knee OA. [less ▲]

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See detailDes situations-limites au dépassement de la situation : phénoménologie d'un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

in Sartre Studies International (2016), 22(1),

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant ... [more ▼]

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant. Notre approche se fonde sur un double mouvement : d’une part, une archéologie du concept dans le contexte de la première percée de la phénoménologie en France dans les années 1930 ; d’autre part, une attention à son possible dépassement deux décennies plus tard. Dans une relation serrée avec les développements de la psychopathologie de son temps, il s’agit d’abord de situer la prétention de l’Esquisse d’une théorie des émotions à poser les bases d’une phénoménologie de « l’homme en situation », ensuite d’éclairer la reprise critique du concept dans Questions de méthode, dans l’exposition de la méthode progressive-régressive. En somme, il s’agit de montrer comment s’élabore progressivement chez Sartre une « herméneutique de l’existence » qui fait droit à la liberté, puis se donne les moyens d’en suivre l’action effective dans le monde. [less ▲]

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See detailCopper tolerance of three Crotalaria species from southeastern D.R. Congo at the early development stage
Boisson, Sylvain ULg; Le Stradic, Soizig ULg; Commans, Morgane et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(2), 151-160

Description of the subject. Microevolutionary processes in metallophytes established on copper enriched soils can lead to a diversity of plant species showing distinct tolerance capacities among genus ... [more ▼]

Description of the subject. Microevolutionary processes in metallophytes established on copper enriched soils can lead to a diversity of plant species showing distinct tolerance capacities among genus. Researches about the relationship between these endangered plants and soil copper concentrations are critical in order to improve ex situ conservation methods in southeastern Democratic Republic of Congo (Katangan Copperbelt). Objectives. The aim of the study was to test the effect of copper on the germination and root elongation of three Crotalariaspecies naturally occurring along a natural copper gradient. The hypothesis is that copper concentrations have different effects on germination and root elongation according to the species of Crotalaria genus.Method. Three species were selected: Crotalaria cobalticola, Crotalaria peschiana and Crotalariacornetii, occurring on soils with the highest to the lowest copper concentrations respectively. Germination and root elongation tests were performed in vitro (MS vitamin-enriched medium) in six copper mediums ranging from 0 to 125 μM Cu2+. Results. No significant differences in germination percentage were observed according to the copper concentrations. Crotalaria cornetii had the lowest germination percentage. Root elongation of C. peschiana did not differ with copper concentration, but root elongation of C. cobalticola was higher at the greatest copper concentration (125 μM Cu2+). Conclusions. Even if C. cobalticola presented better growth at highest Cu concentrations, it appeared that C. cobalticola and C. peschiana do not require copper for their early stages of development and could thus be conserved in non-contaminated substrate. Crotalariacornetii seemed to present a physical seed dormancy. [less ▲]

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See detailSystematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
Daakour, Sarah ULg; Hajingabo, Leon Juvenal; Kerselidou, Despoina et al

in BMC Cancer (2016), 16(1), 335

BACKGROUND: Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and ... [more ▼]

BACKGROUND: Perturbed genotypes in cancer can now be identified by whole genome sequencing of large number of diverse tumor samples, and observed gene mutations can be used for prognosis and classification of cancer subtypes. Although mutations in a few causative genes are directly linked to key signaling pathways perturbation, a global understanding of how known cancer genes drive oncogenesis in human is difficult to assess. METHODS: We collected available information about mutated genes in Acute Lymphoblastic Leukemia (ALL). Validated human protein interactions (PPI) were collected from IntAct, HPRD and BioGRID interactomics databases, or obtained using yeast two-hybrid screening assay. RESULTS: We have mapped interconnections between 116 cancer census gene products associated with ALL. Combining protein-protein interactions data and cancer-specific gene mutations information, we observed that 63 ALL-gene products are interconnected and identified 37 human proteins interacting with at least 2 ALL-gene products. We highlighted exclusive and coexistence genetic alterations in key signaling pathways including the PI3K/AKT and the NOTCH pathways. We then used different cell lines and reporter assay systems to validate the involvement of EXT1 in the Notch pathway. CONCLUSION: We propose that novel ALL-gene candidates can be identified based on their functional association with well-known cancer genes. We identified EXT1, a gene not previously linked to ALL via mutations, as a common interactor of NOTCH1 and FBXW7 regulating the NOTCH pathway in an FBXW7-dependend manner. [less ▲]

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See detailThe development of the abilities to acquire novel detailed orthographic representations and maintain them in long-term memory
Binamé, Florence ULg; Poncelet, Martine ULg

in Journal of Experimental Child Psychology (2016), 143

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained ... [more ▼]

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained variance in the acquisition of word-specific orthographic knowledge that is still underspecified. The main aim of this study was to explore whether two cognitive factors—sensitivity to orthographic regularities and short-term memory (STM) for serial order—make independent contributions to the acquisition of novel orthographic representations beyond that of the phonological core component and the level of preexisting word-specific orthographic knowledge. To this end, we had children from second to sixth grades learn novel written word forms using a repeated spelling practice paradigm. The speed at which children learned the word forms and their long-term retention (1 week and 1 month later) were assessed. Hierarchical regression analyses revealed that phonological recoding, preexisting word-specific orthographic knowledge, and order STM explained a portion of the variance in orthographic learning speed, whereas phonological recoding, preexisting word-specific orthographic knowledge, and orthographic sensitivity each explained a portion of variance in the long-term retention of the newly created orthographic representations. A secondary aim of the study was to determine the developmental trajectory of the abilities to acquire novel orthographic word forms over the course of primary schooling. As expected, results showedan effect of age on both learning speed and long-term retention. The specific roles of orthographic sensitivity and order STM as independent factors involved in different steps of orthographic learning are discussed. [less ▲]

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See detailSludge dewatering and drying: about the difficulty of making experiments with a non-stabilized material
Pambou, Yvon-Bert ULg; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Desalination and Water Treatment (2016), 57(30), 13841-13856

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See detailTetraxylopteris Beck emend. Hammond and Berry (2005), the first aneurophytalean genus recorded in Australia
Meyer-Berthaud, Brigitte; Decombeix, Laure; Dunstone, Robert et al

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 54-65

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See detailHigh Temperature Ferromagnetism in a GdAg2 Monolayer
Ormaza, M.; Fernandez, L.; Ilyn, M. et al

in Nano Letters (2016), 0(0),

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See detailQuantitative assessment of mouse mammary gland morphology using automated digital image processing and TEB detection.
Blacher, Silvia ULg; Gérard, Céline ULg; Gallez, Anne ULg et al

in Endocrinology (2016)

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative ... [more ▼]

The assessment of rodent mammary gland morphology is largely used to study the molecular mechanisms driving breast development and to analyze the impact of various endocrine disruptors with putative pathological implications. In this work, we propose a methodology relying on fully automated digital image analysis methods including image processing and quantification of the whole ductal tree and of the terminal end buds (TEB) as well. It allows to accurately and objectively measure both growth parameters and fine morphological glandular structures. Mammary gland elongation was characterized by two parameters: the length and the epithelial area of the ductal tree. Ductal tree fine structures were characterized by: 1) branch end-point density, 2) branching density and 3) branch length distribution. The proposed methodology was compared to quantification methods classically used in the literature. This procedure can be transposed to several software and thus largely used by scientists studying rodent mammary gland morphology. [less ▲]

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See detailHigh serum sclerostin levels are associated with a better outcome in haemodialysis patients
Jean, Guillaume; Chazot, Charles; Bresson, Eric et al

in Nephron. Clinical Practice (2016)

Sclerostin is an osteocyte hormone that de- creases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chron- ic kidney disease and ... [more ▼]

Sclerostin is an osteocyte hormone that de- creases osteoblastogenesis. Sclerostin may play a key role in osteoporosis and also in vascular calcification (VC). In chron- ic kidney disease and haemodialysis (HD) patients, serum sclerostin levels are high. Aim: To assess the correlation of serum sclerostin levels with VC, bone mineral density (BMD), and survival rate in HD patients. Methods: A cross-sectional study was conducted in prevalent HD patients to correlate serum sclerostin tertiles with the Kauppila aortic calcification score, BMD scores and survival rate. Results: We studied 207 patients who had a mean serum sclerostin level of 1.9 ± 0.7 ng/ml. Compared to patients in the 1st tertile of serum sclerostin levels (0.6–1.53 ng/ml), patients in the 3rd tertile (2.2–4.6 ng/ml) were significantly older (73.7 ± 12 vs. 64.7 ± 18 years), more frequently of the male gender (74 vs. 48%), had lower serum bone-specific alkaline phosphatases values (14 ± 9 vs. 20.4 ± 13 µg/l), were less frequently treated with alfacalcidol, displayed lower aortic calcification scores (9.5 ± 5 vs. 12.5 ± 7/24) and had higher BMD scores. Furthermore, patients of the 3rd tertile displayed a lower mortality rate compared to tertile 1 using multivariable adjusted Cox mod- el (hazard ratio 0.5, 95% CI 0.25–0.93, p = 0.03). The main fac- tors associated with VC score were age, diabetes, cardiovas- cular disease, CRP level and Warfarin use. Conclusion: Our study of HD patients shows that higher serum sclerostin lev- els are associated with higher BMD, lower aortic calcification scores, and a better survival rate. [less ▲]

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See detailL’impact des activités non agricoles sur la pauvreté et l’inégalité rurales dans les groupements Bugorhe et Irhambi-Katana (Territoire de Kabare, Province du Sud-Kivu)
Furaha Mirindi, Germaine ULg; Namegabe Mastaki, Jean Luc; Lebailly, Philippe ULg

in JOURNAL OF ORIENTAL AND AFRICAN STUDIES (2016), 25

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of ... [more ▼]

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of Congo, by comparing a group of households practicing agriculture only and another group which combines agriculture and nonfarm activities. The approach used considers non farm income as an exogenous transfer which completes the whole household income, and analyses the contribution of different sources of income on the inequality in using the Gini index. The results show that inequality increases when a segment of the population does not have access to non-agricultural income. In this case, non farm income is not a substitute of farm income, rather the complement. The poverty analysis is based on the Congolese rural threshold poverty in terms of basic needs to calculate the rate, depth and severity of poverty indexes in using of Foster- Greer-Thorbecke. The results show that households practicing agriculture only are poorer. [less ▲]

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See detailComparison of residual stresses on long rolled profiles measured by X-ray diffraction, ring core and the sectioning methods and simulated by FE method
Bouffioux, Chantal ULg; Pesci, Raphaël; Boman, Romain ULg et al

in Thin-Walled Structures (2016), 104

Sheet piles are produced by hot rolling, a cooling step and, if required, by a straightening operation. Numerical simulations indicate that the stress field is almost homogeneous through the thickness ... [more ▼]

Sheet piles are produced by hot rolling, a cooling step and, if required, by a straightening operation. Numerical simulations indicate that the stress field is almost homogeneous through the thickness, justifying the comparison of X-ray diffraction, ring core and the sectioning methods applied after the cooling step and after the straightening process. The equipment, the steps of the experimental procedures and the results are detailed, showing the limits, the specificities and the advantages of each method. Moreover, the amplitude and the distribution of the stresses along the width of the sections present good agreement with results of numerical simulations. [less ▲]

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See detailWill delayed release metformin provide better management of diabetes type 2?
Scheen, André ULg

in Expert opinion on pharmacotherapy (2016), 17(5), 627-30

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See detailEarthquake imprints on a lacustrine deltaic system: the Kürk Delta along the East Anatolian Fault (Turkey)
Hubert, Aurelia ULg; El Ouahabi, Meriam ULg; Garcia-Moreno, David et al

in Sedimentology (2016)

Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures ... [more ▼]

Deltas contain sedimentary records that are not only indicative of water level changes, but also particularly sensitive to earthquake shaking typically resulting in soft-sediment-deformation structures. The Kürk lacustrine delta lies at the south-western extremity of Lake Hazar in eastern Turkey and is adjacent to the seismogenic East Anatolian Fault (EAF), which has generated earthquakes of magnitude 7. In this paper we have reevaluated water level changes and earthquake shaking that have affected the Kürk Delta combining geophysical data (seismic-reflection profiles and side-scan sonar), remote sensing images, historical data, onland outcrops and offshore coring. The history of water level changes provides a temporal framework for the depositional record. In addition to the commonly soft-sediment-deformation documented previously, onland outcrops reveal a record of deformation (fracturing, tilt and clastic dykes) linked to large earthquake-induced liquefactions and lateral spreading. The recurrent liquefaction structures can be used to obtain a paleoseismological record. Five event horizons were identified that could be linked to historical earthquakes occurring in the last 1000 years along the EAF. Sedimentary cores sampling the most recent subaqueous sedimentation revealed the occurrence of another type of earthquake indicator. Based on radionuclide dating (137Cs and 210Pb), two major sedimentary events were attributed to the 1874-1875 EAF earthquake sequence. Their sedimentological characteristics were determined by X-ray imagery, XRD, LOI, grain-size distribution and geophysical measurements. The events are interpreted to be hyperpycnal deposits linked to post-seismic sediment reworking of earthquake-triggered landslides. [less ▲]

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See detailLymphocytoses B monoclonales : de la revue de la littérature à la pratique de laboratoire.
KEUTGENS, Aurore ULg; Foguenne, Jacques; Gothot, André ULg et al

in Annales de biologie clinique (2016), 74(2), 168-175

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or ... [more ▼]

Monoclonal B-cell lymphocytosis (MBL) is defined as an asymptomatic condition characterized by the presence of less than 5,000 monoclonal B-cells per microliter and the absence of clinical signs or symptoms of a B-cell lymphoproliferative disorder. Most MBL cases involve B cells presenting an identical phenotype to CLL (CLL-like MBL) with a Catovsky-Matutes score of 3 to 5 and share the same chromosomal abnormalities than CLL. Depending on the absolute B cell count, one may distinguish low-count CLL-like MBL (<500 B cells/muL) which have no evidence of progression, no reduction in overall survival, no increase in infection risk and do not require any specific follow-up. Patients with clinical CLL-like MBL (>500 B cells/muL) have a 1% to 2% per year risk of progression to CLL requiring therapy, a higher risk of infectious complications and mortality implicating an annual follow-up by hematologist. MBL may also express other less common phenotypes and are named atypical MBL in case of CD5 antigen expression (Catovsky-Matutes score: 1-2) and non-CLL-like MBL for CD5 negative cases (Catovsky-Matutes score: 0-2). Their poorer prognosis implicates imaging studies, bone marrow biopsy and cytogenetic analysis in addition to physical examination in order to rule out non-hodgkinien lymphoma, and require a more frequent follow-up. This review focuses on key concepts in the classification, diagnosis, monitoring and biology of MBL in laboratory practice. [less ▲]

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See detailLa gouvernance et le financement de l’enseignement supérieur: une approche microéconomique
Jacqmin, Julien ULg

in Reflets et Perspectives de la Vie Economique (2016), 2

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de ... [more ▼]

Cet article examine le fonctionnement de l’enseignement supérieur via une approche microéconomique. Il offre une synthèse des travaux menés lors de ma thèse de doctorat qui s’intéresse aux problèmes de financement et de gouvernance auxquels font face les établissements de ce secteur. Premièrement, le lien entre le financement public du secteur et l’émergence de certains types d’institution est étudié. Ensuite, un modèle mettant en exergue le rôle de la composition du conseil d’administration est présenté. La dernière partie porte sur les conséquences d’une dérégulation des frais d’inscription. En conclusion, quelques aspects de l’enseignement supérieur en Fédération Wallonie-Bruxelles sont présentés à la lumière des différents points abordés. [less ▲]

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See detailRotation of melting ice disks due to melt fluid flow
Dorbolo, Stéphane ULg; adami, nicolas; Dubois, Charles ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2016)

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See detail« La Théorie critique n’a aucun rapport avec la société. » Kluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Tijdschrift voor Filosofie (2016), 78

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to ... [more ▼]

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to create a « reformed circus » which aims at reintroducing some sensuality in the spectator’s experience. Taking this project as well as its central figure, the apparently passive elephant, as a metaphorical starting point, this article reconstitutes a virtual dialogue between the filmmaker and his friend and former master Theodor W. Adorno around the issue of communicability and effectiveness of Critical Theory. Crossing several text fragments by the philosopher (Dialectic of Enlightenment, Resignation and Education After Auschwitz a.o.) with film excerpts, short stories and interviews by Kluge, this dialogue made of real exchanges, as well as direct and indirect quotes of Adorno in Kluge’s films – considered here to be belated joint projects –, finally tries to give an answer to following crucial question: how can Adorno’s critical reflection remain politically, that is socially effective. [less ▲]

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See detailMaximum Entropy Kernels for System Identification
Carli, Francesca Paola ULg; Chen, Tianshi; Ljung, Lennart

in IEEE Transactions on Automatic Control (2016)

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See detailInvestigation on the use of foamed plastic waste as natural aggregates replacement in lightweight mortar
Coppola, Bartolomeo ULg; Courard, Luc ULg; Michel, Frédéric et al

in Composites : Part B, Engineering (2016), 99

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See detailDementia-specific quality of life instruments: a conceptual analysis
Missotten, Pierre ULg; Dupuis, Gilles; Adam, Stéphane ULg

in International Psychogeriatrics (2016)

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the ... [more ▼]

Background: Over the past 20 years, many researchers have worked in developing various methods for measuring quality of life (QoL) of people with dementia. The aim of this review is to develop the conceptual frameworks of the dementia-specific QoL instruments, to identify their evolution over time and to provide elements of reflection on the QoL concept in dementia and its evaluation. Method: An electronic search was conducted on PsycINFO and MEDLINE databases, from January 1985 to June 2015 using a combination of key words that include quality of life, dementia and review. Result: The analysis of the conceptual frameworks of the eighteen selected dementia-specific QoL tools shows a great diversity in: (1) the QoL definitions (e.g. health-related QoL definitions, QoL definitions based on Lawton’s work or similar to this latter); (2) the theoretical QoL models (e.g. Lawton’ work and modified Lawton, adaptation, personhood); (3) the domains and dimensions; (4) the way to construct the instrument (e.g. development based on literature, opinion of the experts) and (5) the items’ formulation (e.g. use of criterion of intensity or frequency). Conclusion: There are different conceptual frameworks in the dementia-specific QoL measures with improvements over time (e.g. inclusion of interesting concepts such as adaptation, taking into account the views of patients themselves). Each of the conceptual parameters (definitions, models, domains and dimensions) is discussed to identify the scales that are conceptually the strongest. Through their review, recommendations for future instrument refinement and development are discussed and a new QoL definition is proposed. [less ▲]

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See detailInterfacial activities of milk total proteose-peptone: contribution and miscibility of nonhydrophobic and hydrophobic fractions
Karamoko, Gaoussou; Renaville, Robert ULg; Blecker, Christophe ULg

in International Dairy Journal (2016), 62

Surface properties of a nonhydrophobic fraction of proteose-peptone (NHFPP) and a hydrophobic fraction of proteose-peptone (HFPP), obtained by hydrophobic-interaction chromatography, were investigated ... [more ▼]

Surface properties of a nonhydrophobic fraction of proteose-peptone (NHFPP) and a hydrophobic fraction of proteose-peptone (HFPP), obtained by hydrophobic-interaction chromatography, were investigated. Adsorption of NHFPP and HFPP on the surface activity of total proteose-peptone (TPP) followed a competitive mechanism, especially during the penetration phase and molecular rearrangements. Compression of mixed monolayers was used to study the miscibility of NHFPP and HFPP within TPP films. When NHFPP was mixed with HFPP, in a TPP film, both fractions were immiscible at the beginning of adsorption; they only became miscible when the polypeptide chains had moved from the surface to the aqueous phase, thus allowing a better organisation of proteins. The equation of excess free energy of compression was used to determine the interactions of NHFPP-HFPP within the TPP film through the mixed monolayer (thermodynamic properties); interactions between NHFPP and HFPP appeared less important than those that occurred between molecules within each fraction. [less ▲]

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See detailPatterns of Loving: Erna Brodber, Nothing's Mat
Romdhani, Rebecca ULg

in SX Salon: A Small Axe Literary Platform (2016), 21

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)
Léonard, Laura ULg; Caprasse, Olivier; Dieux, Xavier et al

in Revue Critique de Jurisprudence Belge [= RCJB] (2016), (1),

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See detailThe transactional process between the relationships with caregivers and children's externalizing behavior
Roskam, Isabelle; Stievenart, Marie ULg; de Mol, Jan

in Journal of Applied Developmental Psychology (2016), 42

Externalizing behavior (EB) has been found to be pervasive in children across different interactional systems. The transactional model is one of the most interesting and plausible mechanisms explaining ... [more ▼]

Externalizing behavior (EB) has been found to be pervasive in children across different interactional systems. The transactional model is one of the most interesting and plausible mechanisms explaining the development of behavioral problems (Sameroff, 2009). The main goal of the study is to test bidirectional and recursive transactional relations between the quality of the caregiver–child relationship and children's externalizing behavior. The transactional model was tested in three-wave longitudinal cross-lagged models involving 117 children (78.5% boys) aged 4 at the beginning of the study and three caregivers, i.e. their mother, father and teacher. All of the children had been clinically referred for externalizing behavior. Themulti-informant three-wave design was an original feature of this research. The results provided no evidence for a transactional process. The results suggest the singularity of each ofthese three interactional systems. They are discussed from the theoretical viewpoint and in terms of their clinical implications. [less ▲]

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See detailCharacterization of saccharides released during an in vitro pepsin-pancreatin digestion of corn flour using HPAEC-PAD
Odjo, Djosse Psijus Sylvanus ULg; Bera, François ULg; Jacquet, Nicolas ULg et al

in Stärke = Starch (2016), 68

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric ... [more ▼]

Saccharides released after an in vitro pepsin-pancreatin digestion of corn flour were quantified and characterized using high-performance anion-exchange chromatography coupled with a pulsed amperometric detector (HPAEC-PAD) and two colorimetric approaches (glucose oxidase/ peroxidase assay and the 3,5-dinitrosalicylic acid assay). HPAEC-PAD revealed five major saccharides as the result of in vitro pepsin-pancreatin digestion of corn grain: glucose, isomaltose, maltose, maltotriose, and glucosyl-maltotriose. Concentrations of glucose released as measured by the three methods assessed are similar when the in vitro pepsin-pancreatin digestion is followed by post incubation with amyloglucosidase. This post incubation unfortunately leads to a loss of information about the degree of polymerization of oligosaccharides that can impact their absorption through intestinal tract. HPAEC-PAD gives both qualitative and quantitative information and then seems more suitable for a nutritional appreciation of the digestion of starchy feedstuffs. [less ▲]

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See detailFDG PET/CT texture analysis for predicting the outcome of lung cancer treated by stereotactic body radiation therapy.
LOVINFOSSE, Pierre ULg; Janvary, Zsolt Levente; COUCKE, Philippe ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]

INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical features, was assessed using univariate and multivariate analysis for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS). Cutoff values were obtained using logistic regression analysis, and survivals were compared using Kaplan-Meier analysis. RESULTS: The median follow-up period was 27.1 months for the entire cohort and 32.1 months for the surviving patients. At the end of the study, 25 patients had local and/or distant recurrence including 12 who died because of the cancer progression. None of the clinical variables was predictive of the outcome, except age, which was associated with DFS (HR 1.1, P = 0.002). None of the 18F-FDG PET/CT or clinical parameters, except gender, were associated with OS. The univariate analysis showed that only dissimilarity (D) was associated with DSS (HR = 0.822, P = 0.037), and that several metabolic measurements were associated with DFS. In multivariate analysis, only dissimilarity was significantly associated with DSS (HR = 0.822, P = 0.037) and with DFS (HR = 0.834, P < 0.01). CONCLUSION: The textural feature dissimilarity measured on the baseline 18F-FDG PET/CT appears to be a strong independent predictor of the outcome in patients with NSCLC treated by SBRT. This may help selecting patients who may benefit from closer monitoring and therapeutic optimization. [less ▲]

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See detailFast Atmospheric Plasma Deposition of Bio-Inspired Catechol/Quinone-Rich Nanolayers to Immobilize NDM-1 Enzymes for Water Treatment
Mauchauffé, Rodolphe; Bonot, Sébastien; Moreno-Couranjou, Maryline et al

in Advanced Materials Interfaces (2016), 3(8), 101002

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See detailShort term impact of selective logging on a western lowland gorilla population
Haurez, Barbara ULg; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Forest Ecology & Management (2016), 364

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services ... [more ▼]

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services through animal-mediated seed dispersal. However, there is no clear understanding of the impacts of logging on wildlife or of the extent to which seed dispersal is preserved in logged forests. Given its tendency for nesting in light gaps, the western lowland gorilla is likely to provide directed-dispersal services to a wide range of tree species. Production forests preserved from poaching have been reported to harbor high densities of gorillas, but the monitoring of gorilla populations subjected to logging is poorly documented. This study investigated gorilla density and nesting behavior after timber exploitation in a logging concession in southeast Gabon. Nest count censuses were performed on line transects, before and after the second felling cycle. Gorilla density dropped from 1.5 (116.7 nests km 2, 95% CI = 83.4–163.5) to 1.0 (64.9 nests km 2, % CI = 32.6–129.5) weaned gorilla km 2 4–6 months after logging, then rose to 2.6 (176.3 nests km 2, 95% CI = 113.5–274.1) gorillas km 2 9–11 months after logging. A consistent preference for nesting in open canopy terra firma forest was observed during all censuses. This study demonstrates the short-term resilience of the western lowland gorilla to selective timber harvesting, and argues that they offer a continued contribution to directed-dispersal services within months after logging. Although a long-term monitoring of gorillas in a logged forest should be undertaken, the role of this species in logged forest recovery is thought to be important. The preservation of gorilla should receive particular consideration by forest managers. [less ▲]

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See detailLa pensée future épisodique : entre simulation et contexte autobiographique
D'Argembeau, Arnaud ULg

in Revue de Neuropsychologie (2016), 8

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See detailAMPK is involved in the differential neonatal performance of chicks hatching at different time
Wang, Yuan ULg; Buyse, J.; Song, Z. et al

in General and Comparative Endocrinology (2016), 228

We have recently reported that the hatching time may be in relation to the distinct neonatal performance of female chicks. The present study was aimed to investigate the potential involvement of AMPK, an ... [more ▼]

We have recently reported that the hatching time may be in relation to the distinct neonatal performance of female chicks. The present study was aimed to investigate the potential involvement of AMPK, an energy sensor which plays a pivotal role in energy homeostasis, in the distinct performance of the spread of hatching time model. As a result, hypothalamic AMPKα1 isoform gene expression was significantly higher in the late hatcher as compared to that of their early counterparts, whereas the total and phosphorylated levels of AMPKα subunit did not differ between the three hatchers. The hypothalamic orexigenic NPY and AgRP mRNA levels were higher in the late hatchers as compared to the early, and that of the middle hatchers was at an intermediate level. However, the anorexigenic POMC and CRH was also higher expressed in the late hatchers as compared to the early hatchers. In the liver, AMPKα2 mRNA level and the phosphorylation ratio of AMPKα was significantly lower in the late hatchers, as compared to their early counterparts. The hepatic phosphorylated GS levels of the late and middle hatchers were lower than that of their early counterparts. The expression of hepatic FTO gene of the late hatchers was significantly higher than that of their early and middle counterparts. Taken together, AMPK may play a significant role in the different neonatal performance of the spread of hatching time model. The central and peripheral AMPK in late hatchers exhibited a pattern of higher energy intake and lower energy expenditure, which resulted in a faster post-hatch growth. © 2016 Elsevier Inc. [less ▲]

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See detailResponse to novely and cocaine stimulant effects: lack of stability across environments in female Swiss mice
Nyssen, Laura ULg; Brabant, Christian ULg; Didone, Vincent ULg et al

in Psychopharmacology (2016), 233

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model ... [more ▼]

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model novelty seeking is the "response to novelty," i.e., the levels of locomotor activity in a new environment. In rodents, a positive correlation was demonstrated between the response to novelty and several effects of drugs, especially the locomotor stimulant effects of cocaine. Objectives: The present study was designed to test in mice whether the response to novelty is stable across environments and whether its relationship with the stimulant effects of cocaine is altered by environmental changes. Experiment 1 assessed the responses to novelty of the same mice in two different novel environments. Experiment 2 tested the correlation between response to novelty and acute stimulant effects of cocaine recorded in two distinct environments. Results: The results show a weak correlation only during the first 5 min of the session between the responses to novelty measured in two distinct environments. Experiment 2 demonstrates that novelty responses and stimulant effects of cocaine are positively correlated only when both behavioral responses are measured in the same environment. In contrast, the relationship between response to novelty and acute stimulant effects of cocaine is completely lost when the behavioral responses are recorded in two different environments. Conclusions: The present results question the usual interpretation of the correlation between the response to novelty and the stimulant effects of cocaine as reflecting a relationship between two underlying individual stable characteristics. [less ▲]

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See detailMesure des flux de CO2 et séquestration de carbone dans les écosystèmes terrestres ouest-africains (Synthèse Bibliographique)
Ago, Expédit Evariste ULg; Agbossou, Euloge Kossi; Ozer, Pierre ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(1), 1-15

In West Africa, as elsewhere in other parts of the world, preserving terrestrial ecosystems has proven essential to any emissions mitigation policy for greenhouse gases, notably carbon dioxide. A ... [more ▼]

In West Africa, as elsewhere in other parts of the world, preserving terrestrial ecosystems has proven essential to any emissions mitigation policy for greenhouse gases, notably carbon dioxide. A meaningful assessment of the contribution of a given region to the global carbon cycle implies the need to think in terms of balance, taking into account the totality of the carbon export and import within the ecosystems [less ▲]

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See detailCore Outcome Measure Index for low back patients: do we miss anxiety and depression?
Cedraschi, C; Marty, M; Courvoisier, DS et al

in European Spine Journal (2016), 25

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See detailThe Changing Landscape of Smoldering Multiple Myeloma: A European Perspective
CAERS, Jo ULg; de Larrea, Carlos; Leleu, Xavier et al

in Oncologist (2016), 21

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating ... [more ▼]

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with highrisk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention, although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group asMM, and thus will require optimalMMtreatment, based on biomarkers that identify patients with a.80% risk of progression. The number of these redefined patients is small (∼10%), but important to unravel, because their risk of progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-highrisk SMM are now considered as MMand may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation needs to be undertaken. For the greater majority ofSMMpatients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. [less ▲]

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See detail. Mass sensor utilising the mode-localisation effect in an electrostatically-coupled MEMS resonator pair fabricated using an SOI process
Wood, Graham; Chun, Zhao; Pu, Suan et al

in Microelectronic Engineering (2016), 159

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode ... [more ▼]

The change in the mass, achieved with focused ion beam(FIB) milling, of one of a pair of electrostatically-coupled microelectromechanical systems (MEMS) resonators has been detected utilising the mode-localisation effect. It has been demonstrated that the shift in the amplitude ratio of the coupled-resonators at the in-phase mode frequency, in response to a mass change, is five orders of magnitude greater than the equivalent resonant frequency shift of a single resonator device. The device has been fabricated using a silicon-on-insulator (SOI) based process, which allows for high-yield and stiction-free fabrication. In addition, the design of the resonators has been created to have a larger surface area than previously reported designs, in order to facilitate future biological functionalisation. The mass sensitivity has been compared to current state-of-the-art mode-localised mass sensors and a 5.4 times increase in the amplitude ratio response to a given mass change has been demonstrated for the device in this work. [less ▲]

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See detailDiscretization of the divergence formulation of the bed slope term in the shallow-water equations and consequences in terms of energy balance
Bruwier, Martin ULg; Archambeau, Pierre ULg; Erpicum, Sébastien ULg et al

in Applied Mathematical Modelling (2016)

In this research, the influence on energy balance of the discretization scheme of the divergence formulation of the bed slope term in the shallow-water equations is analysed theoretically (for a single ... [more ▼]

In this research, the influence on energy balance of the discretization scheme of the divergence formulation of the bed slope term in the shallow-water equations is analysed theoretically (for a single topographic step) and based on two numerical tests. Different values of the main parameter controlling the discretization scheme of the divergence formulation are analysed to identify the formulation which minimizes the energy variation resulting from the discretization. For a wide range of ambient Froude numbers and relative step heights, the theoretical value of the control parameter minimizing the energy variation falls within a very narrow range, which can reasonably be approximated by a single “optimal” value. This is a result of high practical relevance for the design of accurate numerical schemes, as confirmed by the results of the numerical tests. [less ▲]

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See detailThe terrestrialization process: A palaeobotanical and palynological perspective.
Meyer-Berthaud, Brigitte; Servais, Thomas; Vecoli, Marco et al

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 1-3

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See detailElastin density: Link between histological and biomechanical properties of vaginal tissue in women with pelvic organ prolapse?
DE LANDSHEERE, Laurent ULg; Brieu, Mathias; Blacher, Silvia ULg et al

in International Urogynecology Journal & Pelvic Floor Dysfunction (2016)

INTRODUCTION AND HYPOTHESIS: The aim of the study was to correlate histological and biomechanical characteristics of the vaginal wall in women with pelvic organ prolapse (POP). METHODS: Tissue samples ... [more ▼]

INTRODUCTION AND HYPOTHESIS: The aim of the study was to correlate histological and biomechanical characteristics of the vaginal wall in women with pelvic organ prolapse (POP). METHODS: Tissue samples were collected from the anterior [point Ba; POP Questionnaire (POP-Q)] and/or posterior (point Bp; POP-Q) vaginal wall of 15 women who underwent vaginal surgery for POP. Both histological and biomechanical assessments were performed from the same tissue samples in 14 of 15 patients. For histological assessment, the density of collagen and elastin fibers was determined by combining high-resolution virtual imaging and computer-assisted digital image analysis. For biomechanical testing, uniaxial tension tests were performed to evaluate vaginal tissue stiffness at low (C0) and high (C1) deformation rates. RESULTS: Biomechanical testing highlights the hyperelastic behavior of the vaginal wall. At low strains (C0), vaginal tissue appeared stiffer when elastin density was low. We found a statistically significant inverse relationship between C0 and the elastin/collagen ratio (p = 0.048) in the lamina propria. However, at large strain levels (C1), no clear relationship was observed between elastin density or elastin/collagen ratio and stiffness, likely reflecting the large dispersion of the mechanical behavior of the tissue samples. CONCLUSION: Histological and biomechanical properties of the vaginal wall vary from patient to patient. This study suggests that elastin density deserves consideration as a relevant factor of vaginal stiffness in women with POP. [less ▲]

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See detailThere is nothing more pratical than a good theory. Conceptuals tools for the Practioners in Conservation
Verbeeck, Muriel ULg

in Studies in Conservation (2016)

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed ... [more ▼]

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed from Gerard Genette are used to analyze a practical case: Dirty Corner, installation by Anish Kapoor vandalized in the gardens of Versailles. [less ▲]

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See detailThe Calern Asteroid Polarimetric Survey using the Torino Polarimeter: assessment of instrument performances and first scientific results
Devogele, Maxime ULg; Cellino, Alberto; Bagnulo, Stefano et al

in Monthly Notices of the Royal Astronomical Society (2016)

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C ... [more ▼]

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C{\^o}te d'Azur''. Its main purpose is to carry out a polarimetric survey of Solar System objects. This survey is called CAPS (Calern Asteroid Polarimetric Survey). In this paper, the new Torino polarimeter (ToPo) and its preliminary validation campaign is described. The first results of the CAPS survey are also presented. A number of standard stars with known polarization states, as well as a number of asteroids for which the polarimetric properties are known, have been observed in order to assess the instrument accuracy. The instrument response over the field of view and also its stability over single nights and longer periods have also been tested. It has been found that the instrument polarization is stable within a few $10^{-4}$ units. The first polarimetric observations of a still limited number of asteroids show an excellent agreement with previously available data and make already some significant contributions by adding new data to a number of objects that had been poorly observed so far. [less ▲]

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailMale-typical visuospatial functioning in gynephilic girls with gender dysphoria - organizational and activational effects of testosterone.
Burke, Sarah M.; Kreukels, Baudewijntje P. C.; Cohen-Kettenis, Peggy T. et al

in Journal of psychiatry & neuroscience : JPN (2016), 41(4), 150147

BACKGROUND: Sex differences in performance and regional brain activity during mental rotation have been reported repeatedly and reflect organizational and activational effects of sex hormones. We ... [more ▼]

BACKGROUND: Sex differences in performance and regional brain activity during mental rotation have been reported repeatedly and reflect organizational and activational effects of sex hormones. We investigated whether adolescent girls with gender dysphoria (GD), before and after 10 months of testosterone treatment, showed male-typical brain activity during a mental rotation task (MRT). METHODS: Girls with GD underwent fMRI while performing the MRT twice: when receiving medication to suppress their endogenous sex hormones before onset of testosterone treatment, and 10 months later during testosterone treatment. Two age-matched control groups participated twice as well. RESULTS: We included 21 girls with GD, 20 male controls and 21 female controls in our study. In the absence of any group differences in performance, control girls showed significantly increased activation in frontal brain areas compared with control boys (pFWE = 0.012). Girls with GD before testosterone treatment differed significantly in frontal brain activation from the control girls (pFWE = 0.034), suggesting a masculinization of brain structures associated with visuospatial cognitive functions. After 10 months of testosterone treatment, girls with GD, similar to the control boys, showed increases in brain activation in areas implicated in mental rotation. LIMITATIONS: Since all girls with GD identified as gynephilic, their resemblance in spatial cognition with the control boys, who were also gynephilic, may have been related to their shared sexual orientation rather than their shared gender identity. We did not account for menstrual cycle phase or contraceptive use in our analyses. CONCLUSION: Our findings suggest atypical sexual differentiation of the brain in natal girls with GD and provide new evidence for organizational and activational effects of testosterone on visuospatial cognitive functioning. [less ▲]

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See detailLes exercices de contrôle moteur pour le traitement des lombalgies non-spécifiques aiguës
Demoulin, Christophe ULg

in Cochrane Database of Systematic Reviews (Online) (2016)

Traduction en Français du résumé de la revue

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See detailBrabantophyton, a new genus with stenokolealean affinities from a Middle to earliest Upper Devonian locality from Belgium
Momont, Nicolas ULg; Gerrienne, Philippe ULg; Prestianni, Cyrille

in Review of Palaeobotany and Palynology (2016)

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late ... [more ▼]

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late Middle to earliest Upper Devonian) locality of Ronquières (Belgium). The specimens include stems and lateral organs. The stems are characterized by a protostele dissected into three primary ribs, each of them dividing into two secondary ribs. The protostele shows a central protoxylem strand and numerous strands distributed along the midplanes of the ribs. The vascular supply to lateral organ is composed of two pairs of traces, produced at the same time by the two ribs issued from a single primary rib of the protostele. Within each pair, the shape and the size of the traces are unequal: one is T-shaped and the other is oval to reniform. The T-shaped traces of each pair face each other. The inner cortex of the lateral organs is parenchymatous and the outer cortex is sparganum-like. The specimens of Brabantophyton runcariense show many similarities with the stenokolealean genus Crossia virginiana Beck and Stein, but the vascular supply of lateral organs of the latter consists of a more symmetrical and distinctively simpler pair of traces. Brabantophyton represents the first report of the Stenokoleales in southeastern Laurussia. The characteristics of the Brabantophyton protostele compare better with the anatomy of the radiatopses, and, within the latter, particularly with basal seed plants. [less ▲]

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See detailTuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Kumar, Amit; Abbas, Wasim; Colin, Laurence et al

in Scientific reports (2016), 6

Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In ... [more ▼]

Akt signaling plays a central role in many biological processes, which are key players in human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV-1 Nef protein. In primary T cells treated with exogenous Nef or acutely infected with Nef-expressing HIV-1 in vitro, Akt became phosphorylated on serine(473) and threonine(308). In vitro, Akt activation mediated by Nef in T-cells was blocked by HIV protease inhibitors (PI), but not by reverse transcriptase inhibitors (RTI). Ex vivo, we found that the Akt pathway is hyperactivated in peripheral blood lymphocytes (PBLs) from cART naive HIV-1-infected patients. PBLs isolated from PI-treated patients, but not from RTI-treated patients, exhibited decreased Akt activation, T-cell proliferation and IL-2 production. We found that PI but not RTI can block HIV-1 reactivation in latently infected J-Lat lymphoid cells stimulated with various stimuli. Using luciferase measurement, we further confirmed that Nef-mediated reactivation of HIV-1 from latency in 1G5 cells was blocked by PI parallel to decreased Akt activation. Our results indicate that PI-mediated blockade of Akt activation could impact the HIV-1 reservoir and support the need to further assess the therapeutic use of HIV-1 PI in order to curtail latently infected cells in HIV-1-infected patients. [less ▲]

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See detailInterobserver agreement for the ATS/ERS/JRS/ALAT criteria for a UIP pattern on CT.
Walsh, Simon L. F.; Calandriello, Lucio; Sverzellati, Nicola et al

in Thorax (2016), 71(1), 45-51

OBJECTIVES: To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists ... [more ▼]

OBJECTIVES: To establish the level of observer variation for the current ATS/ERS/JRS/ALAT criteria for a diagnosis of usual interstitial pneumonia (UIP) on CT among a large group of thoracic radiologists of varying levels of experience. MATERIALS AND METHODS: 112 observers (96 of whom were thoracic radiologists) categorised CTs of 150 consecutive patients with fibrotic lung disease using the ATS/ERS/JRS/ALAT CT criteria for a UIP pattern (3 categories--UIP, possibly UIP and inconsistent with UIP). The presence of honeycombing, traction bronchiectasis and emphysema was also scored using a 3-point scale (definitely present, possibly present, absent). Observer agreement for the UIP categorisation and for the 3 CT patterns in the entAUe observer group and in subgroups stratified by observer experience, were evaluated. RESULTS: Interobserver agreement across the diagnosis category scores among the 112 observers was moderate, ranging from 0.48 (IQR 0.18) for general radiologists to 0.52 (IQR 0.20) for thoracic radiologists of 10-20 years' experience. A binary score for UIP versus possible or inconsistent with UIP was examined. Observer agreement for this binary score was only moderate. No significant differences in agreement levels were identified when the CTs were stratified according to multidisciplinary team (MDT) diagnosis or patient age or when observers were categorised according to experience. Observer agreement for each of honeycombing, traction bronchiectasis and emphysema were 0.59+/-0.12, 0.42+/-0.15 and 0.43+/-0.18, respectively. CONCLUSIONS: Interobserver agreement for the current ATS/ERS/JRS/ALAT CT criteria for UIP is only moderate among thoracic radiologists, AUrespective of theAU experience, and did not vary with patient age or the MDT diagnosis. [less ▲]

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See detailA Belgian Survey on Geriatric Assessment in Oncology Focusing on Large-Scale Implementation and Related Barriers and Facilitators.
Kenis, C.; Heeren, P.; Decoster, L. et al

in The journal of nutrition, health & aging (2016), 20(1), 60-70

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for ... [more ▼]

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for implementing GA in this setting. Design / setting / participants: The principal investigator of every participating hospital (n=22) was invited to complete a newly developed questionnaire with closed- and open-ended questions. The closed-ended questions surveyed how GA was implemented. The open-ended questions identified barriers and facilitators for the implementation of GA in daily oncology practice. Descriptive statistics and conventional content analysis were performed as appropriate. RESULTS: Qualifying criteria (e.g. disease status and cancer type) for GA varied substantially between hospitals. Thirteen hospitals (59.1%) succeeded to screen more than half of eligible patients. Most hospitals reported that GA data and follow-up data had been collected in almost all screened patients. Implementing geriatric recommendations and formulating new geriatric recommendations at the time of follow-up are important opportunities for improvement. The majority of identified barriers were organizational, with high workload, lack of time or financial/staffing problems as most cited. The most cited facilitators were all related to collaboration. CONCLUSION: Interventions to improve the implementation of GA in older patients with cancer need to address a wide range of factors, with organization and collaboration as key elements. All stakeholders, seeking to improve the implementation of GA in older patients with cancer, should consider and address the identified barriers and facilitators. [less ▲]

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See detailN-Acetylcysteine: An Old Drug With Variable Anti-Influenza Properties
Casanova, Tomas; Garigliany, Mutien-Marie ULg

in Journal of Controversies in Biomedical Research (2016)

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See detailHigh Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
Edwards, M.H.; Parsons, C.; Bruyère, Olivier ULg et al

in Journal of Rheumatology (2016), 43(3), 657-65

Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change ... [more ▼]

Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW). Methods. A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2-3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression. Results. The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = –0.10 (95% CI –0.18, –0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW. Conclusion. The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade. (First Release January 15 2016; J Rheumatol 2016;43:657–65; doi:10.3899/jrheum.150053) [less ▲]

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