References of "Scientific journals"
     in
Bookmark and Share    
Full Text
Peer Reviewed
See detailApport du cathétérisme cardiaque dans le diagnostic et le traitement de la maladie coronarienne avant 40 ans
MEURICE, Caroline; LEGRAND, Victor ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), 71(3), 129-136

Detailed reference viewed: 29 (7 ULg)
Full Text
Peer Reviewed
See detailGrammaire matérielle et erreur de catégorie
Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2016), 12(1),

Detailed reference viewed: 15 (0 ULg)
Full Text
Peer Reviewed
See detailRole of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, Rayan; Vandenbosch, Renaud ULg; Omais, Saad et al

in Scientific Reports (2016)

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailDes situations-limites au dépassement de la situation : phénoménologie d'un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

in Sartre Studies International (2016), 22(1),

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant ... [more ▼]

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant. Notre approche se fonde sur un double mouvement : d’une part, une archéologie du concept dans le contexte de la première percée de la phénoménologie en France dans les années 1930 ; d’autre part, une attention à son possible dépassement deux décennies plus tard. Dans une relation serrée avec les développements de la psychopathologie de son temps, il s’agit d’abord de situer la prétention de l’Esquisse d’une théorie des émotions à poser les bases d’une phénoménologie de « l’homme en situation », ensuite d’éclairer la reprise critique du concept dans Questions de méthode, dans l’exposition de la méthode progressive-régressive. En somme, il s’agit de montrer comment s’élabore progressivement chez Sartre une « herméneutique de l’existence » qui fait droit à la liberté, puis se donne les moyens d’en suivre l’action effective dans le monde. [less ▲]

Detailed reference viewed: 36 (6 ULg)
Full Text
Peer Reviewed
See detailNumerical and experimental study of the glass flow and heat transfer in the continuous glass fiber drawing process
Chouffart, Quentin ULg; Simon, Philippe; Terrapon, Vincent ULg

in Journal of Materials Processing Technology (2016)

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is ... [more ▼]

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is sensitive to numerous disturbances that can cause the fiber to break during the drawing process, and thus reduce the process efficiency. The underlying physics of the forming of a single fiber is investigated here through numerical simulations, and results are validated with measurements obtained on a dedicated experimental unit. Both a two-dimensional axisymmetric and a simplified one-dimensional model are used to simulate the high-temperature region before glass transition. The influence of key parameters and physical mechanisms on the internal stress is investigated through a sensitivity analysis. The simplified model is then used to identify the optimal operating window and to assess the impact of temperature inhomogeneities at the bushing plate. Results show that the initial region close to the tip is critical, and that a low cooling rate reduces the stress. Operating at high tip temperature, large drawing velocity and small tip radius is then found to be the best strategy to minimize the stress. Finally, it is shown that the heat pattern of the bushing plate is one of the most important causes for disturbance in the process. [less ▲]

Detailed reference viewed: 41 (21 ULg)
Full Text
Peer Reviewed
See detailBrabantophyton, a new genus with stenokolealean affinities from a Middle to earliest Upper Devonian locality from Belgium
Momont, Nicolas ULg; Gerrienne, Philippe ULg; Prestianni, Cyrille

in Review of Palaeobotany and Palynology (2016)

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late ... [more ▼]

A new taxon with stenokolealean affinities, Brabantophyton runcariense gen. et sp. nov., is described from seven pyrite permineralized axes collected from the mid Givetian to earliest Frasnian (late Middle to earliest Upper Devonian) locality of Ronquières (Belgium). The specimens include stems and lateral organs. The stems are characterized by a protostele dissected into three primary ribs, each of them dividing into two secondary ribs. The protostele shows a central protoxylem strand and numerous strands distributed along the midplanes of the ribs. The vascular supply to lateral organ is composed of two pairs of traces, produced at the same time by the two ribs issued from a single primary rib of the protostele. Within each pair, the shape and the size of the traces are unequal: one is T-shaped and the other is oval to reniform. The T-shaped traces of each pair face each other. The inner cortex of the lateral organs is parenchymatous and the outer cortex is sparganum-like. The specimens of Brabantophyton runcariense show many similarities with the stenokolealean genus Crossia virginiana Beck and Stein, but the vascular supply of lateral organs of the latter consists of a more symmetrical and distinctively simpler pair of traces. Brabantophyton represents the first report of the Stenokoleales in southeastern Laurussia. The characteristics of the Brabantophyton protostele compare better with the anatomy of the radiatopses, and, within the latter, particularly with basal seed plants. [less ▲]

Detailed reference viewed: 34 (5 ULg)
Full Text
Peer Reviewed
See detailInfluence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with limited oxygen transfer rate.
Carly, F.; Niu, H.; Delvigne, Frank ULg et al

in Journal of industrial microbiology & biotechnology (2016), 43(4), 517-23

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen ... [more ▼]

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen limitation in bioreactor. In the literature, there is lack of report about AOX1 promoter regulation with regard to dissolved oxygen level (DO). Therefore, in this work, chemostat cultures were performed to investigate the cell growth, metabolism and regulation of the AOX1 promoter (pAOX1) regarding co-feeding rate of optimized methanol/sorbitol mixture (methanol fraction 0.60 C-mol/C-mol) using a P. pastoris Mut+/pAOX1-lacZ strain. The oxygen transfer rates (OTR) in bioreactor were kept in the range of typical values of large bioreactor, i.e., 4-8 g/(L h) if DO equals 30 % saturation or 5-10 g/(L h) if DO nears zero. For DO >0, an increase of the carbon fed led to an increase of pAOX1 induction. By contrast, when dissolved oxygen was completely depleted, methanol accumulated, causing a 30 % decrease of pAOX1 induction. However, this decrease is more likely to be lined to methanol accumulation than to low level of dissolved oxygen (<4 % DO). Methanol/sorbitol co-feeding allowed cells to adapt to oxygen transient limitations that often occur at industrial scale with reduced effect on pAOX1 induction. The optimal feeding rate tested here was 6.6 mmol C (DCW h)(-1) at an OTR of 8.28 g O2(L h)(-1) with over fivefold pAOX1 induction (probably directly associated with target protein productivity) compared with previous work. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailShort term impact of selective logging on a western lowland gorilla population
Haurez, Barbara ULg; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Forest Ecology & Management (2016), 364

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services ... [more ▼]

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services through animal-mediated seed dispersal. However, there is no clear understanding of the impacts of logging on wildlife or of the extent to which seed dispersal is preserved in logged forests. Given its tendency for nesting in light gaps, the western lowland gorilla is likely to provide directed-dispersal services to a wide range of tree species. Production forests preserved from poaching have been reported to harbor high densities of gorillas, but the monitoring of gorilla populations subjected to logging is poorly documented. This study investigated gorilla density and nesting behavior after timber exploitation in a logging concession in southeast Gabon. Nest count censuses were performed on line transects, before and after the second felling cycle. Gorilla density dropped from 1.5 (116.7 nests km 2, 95% CI = 83.4–163.5) to 1.0 (64.9 nests km 2, % CI = 32.6–129.5) weaned gorilla km 2 4–6 months after logging, then rose to 2.6 (176.3 nests km 2, 95% CI = 113.5–274.1) gorillas km 2 9–11 months after logging. A consistent preference for nesting in open canopy terra firma forest was observed during all censuses. This study demonstrates the short-term resilience of the western lowland gorilla to selective timber harvesting, and argues that they offer a continued contribution to directed-dispersal services within months after logging. Although a long-term monitoring of gorillas in a logged forest should be undertaken, the role of this species in logged forest recovery is thought to be important. The preservation of gorilla should receive particular consideration by forest managers. [less ▲]

Detailed reference viewed: 42 (6 ULg)
Full Text
Peer Reviewed
See detailCompte-rendu de Andrea Nicolotti, Le Saint Suaire de Besançon et le chevalier Othon de la Roche
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

Detailed reference viewed: 50 (1 ULg)
Full Text
Peer Reviewed
See detailThe Changing Landscape of Smoldering Multiple Myeloma: A European Perspective
CAERS, Jo ULg; de Larrea, Carlos; Leleu, Xavier et al

in Oncologist (2016), 21

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating ... [more ▼]

Smoldering multiple myeloma (SMM) is an asymptomatic clonal plasma cell disorder and bridges monoclonal gammopathyof undeterminedsignificance tomultiplemyeloma(MM), based on higher levels of circulating monoclonal immunoglobulin and bone marrow plasmocytosis without end-organ damage. Until a Spanish study reported fewer MM-related events and better overall survival among patients with highrisk SMM treated with lenalidomide and dexamethasone, prior studies had failed to show improved survival with earlier intervention, although a reduction in skeletal-related events (without any impact on disease progression) has been described with bisphosphonate use. Risk factors have now been defined, and a subset of ultra-high-risk patients have been reclassified by the International Myeloma Working Group asMM, and thus will require optimalMMtreatment, based on biomarkers that identify patients with a.80% risk of progression. The number of these redefined patients is small (∼10%), but important to unravel, because their risk of progression to overt MM is substantial ($80% within 2 years). Patients with a high-risk cytogenetic profile are not yet considered for early treatment, because groups are heterogeneous and risk factors other than cytogenetics are deemed to weight higher. Because patients with ultra-highrisk SMM are now considered as MMand may be treated as such, concerns exist that earlier therapy may increase the risk of selecting resistant clones and induce side effects and costs. Therefore, an even more accurate identification of patients who would benefit from interventions needs to be performed, and clinical judgment and careful discussion of pros and cons of treatment initiation needs to be undertaken. For the greater majority ofSMMpatients, the standard of care remains observation until development of symptomatic MM occurs, encouraging participation in ongoing and upcoming SMM/early MM clinical trials, as well as consideration of bisphosphonate use in patients with early bone loss. [less ▲]

Detailed reference viewed: 100 (9 ULg)
Full Text
See detailLES CONDITIONS DU COMMUN À L’ÉPREUVE DE SA CONSTRUCTION ; restitution d’une enquête en cours sur la vallée de la Vilaine, Rennes.
Bodart, Céline ULg; Pihet, Valérie

in Lieux Communs (2016), 18(automne),

Dans cette proposition d'article, il sera question de mettre en avant l’originalité et la pertinence de l’approche de Cuesta en tant que lieu de recherche non-institutionnalisé, à partir d’une ... [more ▼]

Dans cette proposition d'article, il sera question de mettre en avant l’originalité et la pertinence de l’approche de Cuesta en tant que lieu de recherche non-institutionnalisé, à partir d’une expérimentation actuellement menée sur le territoire rennais. Cuesta est une structure coopérative récemment formée par une urbaniste et une productrice, et dont l'objectif est de faire intervenir les processus artistiques en amont des projets d'aménagement, pour leur permettre d'impacter sur ceux-ci. Cet article proposera alors une « relecture » des intentions de Cuesta à partir de la théorie politique du philosophe américain, John Dewey, afin de voir comment considérer ce type de travail comme la mise en place de dispositifs d'enquête visant à reconstruire un cadre spécifique d'expérience pour qu'un public puisse s'auto-constituer autour de problématiques situées. De ce croisement entre théorie et pratique, le but sera d'interroger les logiques de constitution du laboratoire au regard de cette approche innovante considérée comme nouveau type de recherche territoriale. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa et al

in Autophagy (2016), 12(1), 1-222

Detailed reference viewed: 92 (7 ULg)
Full Text
Peer Reviewed
See detailL'impôt sur les revenus des salariés et l'extranéité (2e partie)
Docclo, Caroline ULg

in Journal des Tribunaux du Travail (2016)

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailImpact of Serial B-Type Natriuretic Peptide Changes for Predicting Outcome in Asymptomatic Patients With Aortic Stenosis.
Henri, Christine; DULGHERU, Raluca Elena ULg; Magne, Julien et al

in The Canadian journal of cardiology (2016)

BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis ... [more ▼]

BACKGROUND: The aim of this study was to determine the impact on the outcome of serial B-type natriuretic peptide (BNP) changes during follow-up in asymptomatic patients with >/= moderate aortic stenosis (AS) and preserved left ventricular ejection fraction. METHODS: We prospectively screened 69 patients who underwent comprehensive transthoracic echocardiography, BNP level measurement at baseline and after every 6 or 12 months. Annualized BNP changes were calculated as the difference between the last and baseline BNP measurements divided by the duration of follow-up. The primary endpoint was the occurrence of symptoms, aortic valve replacement, or cardiovascular death. RESULTS: During a follow-up of 30 +/- 19 months, 43 patients experienced a cardiac event. These patients were significantly older (73 +/- 9 vs 65 +/- 16 years; P = 0.010), had more often dyslipidemia (79% vs 42%; P = 0.038), more severe AS (peak velocity: 3.9 +/- 0.6 vs 3.5 +/- 0.6 m/s; P = 0.002), larger indexed left atrial area (10.2 +/- 2.5 vs 8.7 +/- 1.9 cm2/m2; P = 0.006), and a higher increase in annualized BNP (+90 +/- 155 vs +7 +/- 49 pg/mL/y; P = 0.010). Patients with higher annualized BNP changes (> 20 pg/mL/y) had a significantly lower cardiac event-free survival (1 year: 63 +/- 8% vs 97 +/- 3%; 3 years: 31 +/- 8% vs 68 +/- 8%; P < 0.001). Using the multivariate Cox proportional hazards model, higher annualized BNP changes were significantly associated with increased risk of cardiac events (hazard ratio: 2.73, 95% confidence interval: 1.27-5.86; P = 0.010) after adjustment for age, dyslipidemia, and echocardiographic parameters. CONCLUSIONS: In asymptomatic patients with AS and preserved left ventricular ejection fraction, the use of serial BNP changes may help to anticipate development of class I indication for aortic valve replacement. [less ▲]

Detailed reference viewed: 33 (5 ULg)
Peer Reviewed
See detailConvective drying behavior of sawdust-sludge mixtures in a fixed bed
Li, Jie; Fraikin, Laurent ULg; Salmon, Thierry ULg et al

in Drying Technology (2016), 34(4), 395-402

Detailed reference viewed: 25 (9 ULg)
Full Text
Peer Reviewed
See detailStructural Proteomics of Herpesviruses.
Leroy, Baptiste; Gillet, Laurent ULg; Vanderplasschen, Alain ULg et al

in Viruses (2016), 8(2),

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have ... [more ▼]

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome of numerous herpesviruses has been sequenced, the exact composition of virions remains unknown for most of them. Mass spectrometry has recently emerged as a central method and has permitted fundamental discoveries in virology. Here, we review mass spectrometry-based approaches that have recently allowed a better understanding of the composition of the herpesvirus virion. In particular, we describe strategies commonly used for proper sample preparation and fractionation to allow protein localization inside the particle but also to avoid contamination by nonstructural proteins. A collection of other important data regarding post-translational modifications or the relative abundance of structural proteins is also described. This review also discusses the poorly studied importance of host proteins in herpesvirus structural proteins and the necessity to develop a quantitative workflow to better understand the dynamics of the structural proteome. In the future, we hope that this collaborative effort will assist in the development of new strategies to fight these infections. [less ▲]

Detailed reference viewed: 20 (6 ULg)
Full Text
Peer Reviewed
See detailN-Acetylcysteine: An Old Drug With Variable Anti-Influenza Properties
Casanova, Tomas; Garigliany, Mutien-Marie ULg

in Journal of Controversies in Biomedical Research (2016)

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailBiotic homogenization can decrease landscape-scale forest multifunctionality
van der Plas, Fons; Manning, Pete; Soliveres, Santiago et al

in Proceedings of the National Academy of Sciences (2016)

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of ... [more ▼]

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of biodiversity in driving ecosystem multifunctionality at landscape scales remains unresolved. We used a comprehensive pan-European dataset, including 16 ecosystem functions measured in 209 forest plots across six European countries, and performed simulations to investigate how local plot-scale richness of tree species (α-diversity) and their turnover between plots (β-diversity) are related to landscape-scale multifunctionality. After accounting for variation in environmental conditions, we found that relationships between α-diversity and landscape-scale multifunctionality varied from positive to negative depending on the multifunctionality metric used. In contrast, when significant, relationships between β-diversity and landscape-scale multifunctionality were always positive, because a high spatial turnover in species composition was closely related to a high spatial turnover in functions that were supported at high levels. Our findings have major implications for forest management and indicate that biotic homogenization can have previously unrecognized and negative consequences for large-scale ecosystem multifunctionality. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailRisk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.
Garigliany, Mutien-Marie ULg; Jolly, Sandra ULg; Dive, M. et al

in The Veterinary record (2016), 178(2), 45

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in ... [more ▼]

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in 302 stray cats captured during a trap-neuter-release programme in a mixed urban-rural area from Belgium, from 2010 to 2012. The impact of selective removal of FIV-positive cats on the apparent prevalence in the remaining population over this three-year period was also assessed. The seroprevalences over three years were 18.8 per cent for FIV and 0.7 per cent for FeLV. For FIV, the seroprevalence decreased significantly from the first year of the programme (2010; 30.5 per cent) to the last (2012; 13.1 per cent). Sex (male) and age (adult and old cats) were risk factors, while the year of sampling (years 2011 and 2012) was a protective factor. Age, sex and location were the most relevant predictors of FIV status. The data presented in this study revealed a very high FIV seroprevalence in Belgian stray cats, while FeLV was almost absent. The selective removal of positive cats had a drastic effect on the FIV seroprevalence in the remaining cat population. [less ▲]

Detailed reference viewed: 10 (3 ULg)
Full Text
Peer Reviewed
See detailApoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility.
Fouchecourt, S.; Livera, G.; Messiaen, S. et al

in Cell death and differentiation (2016)

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction ... [more ▼]

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction. We specifically tested this possibility by ablating Mdm2, an E3 ligase that regulates p53 protein stability and transactivation function, specifically in Sertoli cells (SCs) using the AMH-Cre line and created the new SC-Mdm2-/- line. Heterozygous SC-Mdm2-/+ adult males were fertile, but SC-Mdm2-/- males were infertile and exhibited: a shorter ano-genital distance, an extra duct along the vas deferens that presents a uterus-like morphology, degenerated testes with no organized seminiferous tubules and a complete loss of differentiated germ cells. In adults, testosterone levels as well as StAR, P450c17 (Cyp17a1) and P450scc (Cyp11a1) mRNA levels decreased significantly, and both plasma LH and FSH levels increased. A detailed investigation of testicular development indicated that the phenotype arose during fetal life, with SC-Mdm2-/- testes being much smaller at birth. Interestingly, Leydig cells remained present until adulthood and fetal germ cells abnormally initiated meiosis. Inactivation of Mdm2 in SCs triggered p53 activation and apoptosis as early as 15.5 days post conception with significant increase in apoptotic SCs. Importantly, testis development occurred normally in SC-Mdm2-/- lacking p53 mice (SC-Mdm2-/-p53-/-) and accordingly, these mice were fertile indicating that the aforementioned phenotypes are entirely p53-dependent. These data not only highlight the importance of keeping p53 in check for proper testicular development and male fertility but also certify the critical role of SCs in the maintenance of meiotic repression.Cell Death and Differentiation advance online publication, 16 October 2015; doi:10.1038/cdd.2015.120. [less ▲]

Detailed reference viewed: 10 (5 ULg)
Full Text
Peer Reviewed
See detailĐánh giá tiềm năng sử dụng phụ phẩm ngành rượu cồn để sản xuất thức ăn chăn nuôi tại Việt Nam
Tu Viet, Phu; Pham Kim, Dang; Nguyen Cong, Oanh ULg et al

in Journal of Science and Development (2016), 14(1), 36-45

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high ... [more ▼]

The output of country's livestock sector is relatively high compared to other countries in the region and is estimated at 4.6 million tons of meat per year. The main constraint in the sector is the high feed price due to the dependence on imported raw materials (estimated at 65-70%). The total value of imported raw materials for animal feed production in 2013 was estimated at $ 4.1 billion. Worldwide, by-products from alcohol industry has been studied and processed into main raw materials (DDG and DDGS) for animal feed production. Meanwhile in our country, these by-products are used in its raw form in livestock feeding or used for other purposes with low economic benefit. The objective of this study was to evaluate the potential uses of the by-products from alcohol industry to produce animal feed and increase the added value for these products. The main methods used in this study were Value Chain Analysis (VCA) and SWOT analysis. Results of the study showed the different value chains of the alcohol industry as well as opportunities for the use of by-products for the production of animal feed. The results also indicate the difficulties and challenges of these application. [less ▲]

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailThere is nothing more pratical than a good theory. Conceptuals tools for the Practioners in Conservation
Verbeeck, Muriel ULg

in Studies in Conservation (2016)

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed ... [more ▼]

This paper sheds light on the efficiency of philosophical conceptualization to grasp the modalities of contemporary art. The concepts of intentionality, attentionality and aesthetic functionality borrowed from Gerard Genette are used to analyze a practical case: Dirty Corner, installation by Anish Kapoor vandalized in the gardens of Versailles. [less ▲]

Detailed reference viewed: 30 (1 ULg)
Full Text
Peer Reviewed
See detailRecurrent pulsations in Saturn’s high latitude magnetosphere
Mitchell, D.G.; Carbary, J.F.; Bunce, E.J. et al

in Icarus (2016)

Detailed reference viewed: 14 (3 ULg)
Full Text
Peer Reviewed
See detailStructured carbons as supports for hydrogenation hybrid catalysts prepared by the immobilization of a Rh diamine complex
Gheorghiu, Cristina; Garcia-Bordeje, Enrique; Job, Nathalie ULg et al

in Chemical Engineering Journal (2016), 291

Detailed reference viewed: 49 (8 ULg)
Full Text
Peer Reviewed
See detailFully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging
Henrottin, Jean ULg; Lemaire, Christian ULg; Egrise, Dominique et al

in Nuclear Medicine & Biology (2016)

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor ... [more ▼]

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-DL-tryptophan (1-[19F]FE-DL-Trp) was reported as a good and specific substrate of this enzyme. Herein, the radiosynthesis of its radioactive isotopomer (1-[18F]FE-DL-Trp, DL-[18F]5) is presented along with in vitro enzymatic and cellular uptake studies. Methods: The one-pot n.c.a. radiosynthesis of this novel potential PET imaging tracer, including HPLC purification and formulation, has been fully automated on a FASTlabTM synthesizer. Chiral separation of both isomers and their formulation were implemented on a second cassette. In vitro enzymatic and cellular uptake studies were then conducted with the D-, L- and DL-radiotracers. Results: The radiolabeling of the tosylate precursor was performed in DMF (in 5 min; RCY: 57% (d.c.), n=3). After hydrolysis, HPLC purification and formulation, DL-[18F]5 was obtained with a global radiochemical yield of 18±3% (not decay corrected, n=7, in 80 min) and a specific activity of 600±180 GBq/µmol (n=5). The subsequent separation of L- and D-enantiomers was performed by chiral HPLC and both were obtained after formulation with a RCY (d.c.) of 6.1% and 5.8%, respectively. In vitro enzymatic assays reveal that L-[18F]5 is a better substrate than D-[18F]5 for human IDO. In vitro cellular assays show an IDO-specific uptake of the racemate varying from 30% to 50% of that of L-[18F]5, and a negligible uptake of D-[18F]5. Conclusion: In vitro studies show that L-[18F]5 is a good and specific substrate of hIDO, while presenting a very low efflux. These results confirm that L-[18F]5 could be a very useful PET radiotracer for IDO expressing cells in cancer imaging. [less ▲]

Detailed reference viewed: 34 (9 ULg)
Full Text
Peer Reviewed
See detailTrace Elements in Marine Environments : Occurrence, Threats and Monitoring with Special Focus on the Costal Mediterranean
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Journal of Environmental and Analytical Toxicology (2016), 6:1

Trace elements, as building blocks of matter, are naturally present in the environment. However, their extraction, production, use and release by men can lead to the increase of their environmental levels ... [more ▼]

Trace elements, as building blocks of matter, are naturally present in the environment. However, their extraction, production, use and release by men can lead to the increase of their environmental levels to concentrations that may be toxic for both men and the biota. The overall aim of this review is therefore to recall that trace elements remain contaminants of concern that still require scientific attention. Because marine coastal systems (and transitional environments in general) are particularly vulnerable to contamination processes, they deserve to be accurately monitored with quality indicator species. As an example, the 2 most widely quality indicator species used to assess the health status of the coastal Mediterranean are the seagrass Posidonia oceanica and the mussel Mytilus galloprovincialis. In this review, after a short introduction on human pressures on the World Ocean and the coastal Mediterranean in particular (1), we will redefine the term trace element from an environmental perspective and discuss their accumulation and toxicity for men and the biota (2). We will consider the benefits of using biological indicators instead of water and sediment measurements to assess the health status of the marine environment (3), and more particularly as regards the accurate and complementary indicators that are seagrasses (4) and mussels (5). [less ▲]

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDefining multiplication in some additive expansions of polynomial rings
Point, Françoise; Rigo, Michel ULg; Waxweiler, Laurent

in Communications in Algebra (2016), 44

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this ... [more ▼]

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this applies to polynomial rings over a finite field. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailOn-demand continuous flow production of pharmaceuticals in a compact, reconfigurable system
Adamo, Andrea; Beingessner, Rachel L.; Behnam, Mohsen et al

in Science (2016), 352

Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a ... [more ▼]

Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation. [less ▲]

Detailed reference viewed: 47 (11 ULg)
Full Text
Peer Reviewed
See detailLearning of interval and general type-2 fuzzy logic systems using simulated annealing: Theory and practice
Almaraashi, Majid; John, Robert; Hopgood, Adrian ULg et al

in Information Sciences (2016)

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for ... [more ▼]

This paper reports the use of simulated annealing to design more efficient fuzzy logic systems to model problems with associated uncertainties. Simulated annealing is used within this work as a method for learning the best configurations of interval and general type-2 fuzzy logic systems to maximize their modeling ability. The combination of simulated annealing with these models is presented in the modeling of four benchmark problems including real-world problems. The type-2 fuzzy logic system models are compared in their ability to model uncertainties associated with these problems. Issues related to this combination between simulated annealing and fuzzy logic systems, including type-2 fuzzy logic systems, are discussed. The results demonstrate that learning the third dimension in type-2 fuzzy sets with a deterministic defuzzifier can add more capability to modeling than interval type-2 fuzzy logic systems. This finding can be seen as an important advance in type-2 fuzzy logic systems research and should increase the level of interest in the modeling applications of general type-2 fuzzy logic systems, despite their greater computational load. [less ▲]

Full Text
Peer Reviewed
See detailBlowing a liquid curtain
Lhuissier, Henri; Brunet, Philippe; Dorbolo, Stéphane ULg

in Journal of Fluid Mechanics (2016), 795

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailDe la matérialisation de quelques concepts phénoménologiques.
Frère, Bruno ULg

in SociologieS (2016)

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été ... [more ▼]

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été d’usage mais s’avère aujourd’hui urgent. En effet, faisant l’économie d’une considération sérieuse de la prise que lui offre la sociologie sur le monde, la philosophie risque d’échouer à penser les transformations politiques et économiques des société contemporaines. A l’inverse, une certaine tendance positiviste semble menacer la sociologie qui se débarrasserait de toutes connaissances philosophiques. Afin de rappeler l’intérêt que l’une et l’autre se doivent réciproquement, cet article voudrait montrer comment il peut être utile à la sociologie de donner corps à certains concepts philosophiques lorsqu’elle s’avère confrontée à certaines difficultés. Afin d’illustrer le propos, nous nous référerons à un exemple puisé au sein de l’économie solidaire. Ici en effet, c’est en acceptant que se matérialise dans l’enquête le concept d’état d’esprit intentionnel que la philosophie phénoménologique vient à point nommé pour aider la sociologie pragmatique de la critique à se représenter les contradictions qui peuvent apparaître entre action et justification. Et ce sans pour autant renoncer à « prendre les gens aux sérieux » et s’en retourner vers une traditionnelle sociologie du dévoilement qui expliquerait ces contradictions par le décalage qui existerait entre habitus (ou sens pratique) d’une part et illusions réflexives des acteurs d’autre part. Mots clefs : phénoménologie, états d’esprit intentionnel, philosophie, sociologie pragmatique, économie solidaire. Summary : This article is a reflexion about the relationship between sociology and philosophy. It will show that building bridges between the two disciplines, whilst recurrent, is more urgent now than ever. On the one hand, philosophy will be unable to contribute meaningfully to discussions about the major political and economic transformations experienced by contemporary societies without engaging with Sociology. On the other hand without philosophical insights Sociology risks drifting towards positivistic trends. In this article we propose to show how each discipline can benefit from cross-fertilisations and in particular how Sociology can appropriate philosophical concepts to address certain challenges. Drawing on a specific example from solidary economy, we will show that the concept of intentional mindset borrowed from phenomenological philosophy enables pragmatic sociology to account for the gaps which are liable to emerge between action and justification. This concept fulfills the key tenet of pragmatic sociology that to take social actors seriously we must eschew a type of sociological approach which would consist of revealing that the gaps between action and justification arise from social actors’ illusory apprehension of their habitus. Key words: phénoménology, mindset, states of mind, philosophy, pragmatic sociology, solidarity economy. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detailFe3+/Iron Oxide/SiO2 Xerogel Catalysts for p-nitrophenol Degradation by Photo-Fenton Effects: Influence of Thermal Treatment on Catalysts Texture
Mahy, Julien ULg; Tasseroul, Ludivine ULg; Herlitscke, Marcus et al

in Materials Today: Proceedings (2016), 3(2), 464-469

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. Four thermal treatments were applied to catalysts: drying, drying-autoclaving, calcination and calcination-autoclaving. Textural characterizations show that the specific surface area is increased by calcination while materials microporosity completely collapse when using autoclaving. Based on Mössbauer spectroscopy and magnetometry measurements, only Fe3+ species were observed in xerogel catalysts. The photo-Fenton effect of these catalysts was evaluated on the degradation of p-nitrophenol in aqueous media. In the presence of H2O2, results show that this effect reachs 99% of degradation after 24 h. Mössbauer and catalytic tests are presented in another paper. [less ▲]

Detailed reference viewed: 47 (26 ULg)
Full Text
Peer Reviewed
See detailGrowth hormone releasing hormone excess and blockade in X-LAG syndrome.
Daly, Adrian Francis ULg; Lysy, Philippe; Defilles, Celine et al

in Endocrine-related cancer (2016)

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and ... [more ▼]

X-linked acrogigantism (X-LAG) syndrome is a newly-described form of inheritable pituitary gigantism that begins in early childhood and is usually associated with markedly elevated growth hormone (GH) and prolactin secretion by mixed pituitary adenomas/hyperplasia. Microduplications on chromosome Xq26.3 including the GPR101 gene cause X-LAG syndrome. In individual cases random GH-releasing hormone (GHRH) levels have been elevated. We performed a series of hormonal profiles in a young female sporadic X-LAG syndrome patient and subsequently undertook in vitro studies of primary pituitary tumor culture following neurosurgical resection. The patient demonstrated consistently elevated circulating GHRH levels throughout preoperative testing, which was accompanied by marked GH and prolactin hypersecretion; GH demonstrated a paradoxical increase following TRH administration. In vitro, the pituitary cells showed baseline GH and prolactin release that was further stimulated by GHRH administration. Co-incubation with GHRH and the GHRH receptor antagonist, acetyl-(D-Arg(2))-GHRH (1-29) amide, blocked the GHRH-induced GH stimulation; the GHRH receptor antagonist alone significantly reduced GH release. Pasireotide, but not octreotide, inhibited GH secretion. A ghrelin receptor agonist and an inverse agonist led to modest, statistically significant increases and decreases in GH secretion, respectively. GHRH hypersecretion can accompany the pituitary abnormalities seen in X-LAG syndrome. These data suggest that the pathology of X-LAG syndrome may include hypothalamic dysregulation of GHRH secretion, which is in keeping with localization of GPR101 in the hypothalamus. Therapeutic blockade of GHRH secretion could represent a way to target the marked hormonal hypersecretion and overgrowth that characterizes X-LAG syndrome. [less ▲]

Detailed reference viewed: 27 (8 ULg)
Full Text
Peer Reviewed
See detailPermeability evolution and water transfer in the excavation damaged zone of a ventilated gallery
Pardoen, Benoît ULg; Talandier, Jean; Collin, Frédéric ULg

in International Journal of Rock Mechanics & Mining Sciences (2016), 85

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers ... [more ▼]

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers are mainly conditioned by the behaviour of the surrounding material and by its interaction with the gallery air. The hydro-mechanical behaviour of the excavation damaged zone, which develops around galleries due to the drilling process, is thenceforward critical because it is composed of fractures having a significant irreversible impact on flow characteristics and transfer kinetics. Besides, the material interaction with the gallery air may engender water drainage and desaturation. Thus, a gallery air ventilation experiment, preceded by its excavation, is numerically modelled in an unsaturated argillaceous rock to study its influence on hydraulic transfers. The fractures are numerically represented with shear strain localisation bands by means of a microstructure enriched model including a regularisation method. The impact of fracturing on the transport properties is addressed by associating the intrinsic permeability increase with mechanical deformation which is amplified in the strain localisation discontinuities. Such dependence permits us to reproduce a significant permeability increase of several orders of magnitude in the excavation damaged zone, in agreement with available experimental measurements. After the excavation, the hydraulic transfers are studied through the reproduction of a gallery air ventilation experiment that implies drainage and desaturation of the surrounding rock. These transfers depend on liquid water and water vapour exchanges at gallery wall that are introduced through a non-classical boundary condition. The model prediction successfully captures the drainage and desaturation kinetics of undisturbed and damaged rock. [less ▲]

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailPolylactide-based microspheres prepared using solid-state copolymerized chitosan and D,L-lactide
Demina, Tatiana; Akopova, T.A.; Vladimirov, L.V. et al

in Materials Science and Engineering: A (2016), C59

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailLogistics Service Quality: The Case of Da Nang City
Limbourg, Sabine ULg; Giang, Ho Thi Quynh; Cools, Mario ULg

in Procedia Engineering (2016), 142

Cost minimization is a key objective in managing logistics services. In this context, a growing interest in quality improvement can be observed. However, service quality is hard to quantify as it is a ... [more ▼]

Cost minimization is a key objective in managing logistics services. In this context, a growing interest in quality improvement can be observed. However, service quality is hard to quantify as it is a function of varying customer perceptions over time, of the measurement process and of the analysis of the data gathered. This study examines the logistics service quality by scales developed according to SERVQUAL instrument. A survey of 200 customers of logistics service providers (LSP) was conducted in Da Nang City. The data analysis shows that LSPs in Da Nang city need to improve Research and Development and to develop Customer Care programs. [less ▲]

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailScreening for GPR101 defects in pediatric pituitary corticotropinomas.
Trivellin, Giampaolo; Correa, Ricardo R.; Batsis, Maria et al

in Endocrine-related cancer (2016)

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been ... [more ▼]

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas. We performed GPR101 sequencing, expression analyses by RT-qPCR and immunostaining, and functional studies (cell proliferation, pituitary hormones secretion, and cAMP measurement) in a series of patients with sporadic CD secondary to ACTH-secreting adenomas in whom we had peripheral and tumor DNA (N=36). No increased GPR101 expression was observed in tumors compared to normal pituitary (NP) tissues, nor did we find a correlation between GPR101 and ACTH expression levels. Sequence analysis revealed a very rare germline heterozygous GPR101 variant (p.G31S) in one patient with CD. Overexpression of the p.G31S variant did not lead to increased growth and proliferation, although modest effects on cAMP signaling were seen. GPR101 is not overexpressed in ACTH-secreting tumors compared to NPs. A rare germline GPR101 variant was found in one patient with CD but in vitro studies did not support a consistent pathogenic effect. GPR101 is unlikely to be involved in the pathogenesis of CD. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailAirewater interfacial properties of enzymatic wheat gluten hydrolyzates determine their foaming behavior
Wouters, Arno G.B.; Rombouts, Ine; Legein, Marie et al

in Food Hydrocolloids (2016), 55

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different ... [more ▼]

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different peptic and tryptic wheat gluten hydrolyzates were related to the kinetics of their adsorption at an airewater interface as well as to the properties of a compressed protein film at this interface. Foams from degree of hydrolysis (DH, i.e. the percentage of cleaved peptide bonds) 2 hydrolyzates were more stable than those from their DH 6 counterparts, and this at all protein concentrations tested. However, at protein concentrations from 0.010% to 0.050% (wprot/v), peptic DH 2 and 6 hydrolyzates had better foaming stability than their tryptic counterparts of the same DH. The opposite was observed when protein concentrations ranged from 0.050% to 0.150% (wprot/v). These observations can in part be explained by the molecular mass composition of the samples and, more importantly, by high levels of hydrophobic peptides in the DH 2 samples. The calculation of an average elasticity (up to 20e25 mN/m) from the variation in surface pressure for a variation in surface area in Langmuir isotherms showed that DH 2 samples had higher elasticity than DH 6 samples, which was in agreement with their foaming stabilities at various protein concentrations. Additionally, although not usually considered in literature, it seemed there was a correspondence between surface pressure at different protein surface concentrations and foaming stability at different protein concentrations. [less ▲]

Detailed reference viewed: 17 (1 ULg)
Full Text
Peer Reviewed
See detailAssessment of the entering stock, migration dynamics and fish pass fidelity of european eel in the belgian meuse river
Nzau Matondo, Billy ULg; Benitez, Jean-Philippe ULg; Dierckx, Arnaud ULg et al

in River Research & Applications (2016)

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to ... [more ▼]

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to distinguish resident and migrating eels. From April to September 2013, 435 eels (P50 length, 403 mm; range, 196–836 mm) were caught (daily maxima catch, 90 eels per day), 90% between 13 June and 1 August (50 days) and P50 on 19 July. Eels migrated mostly at 19–26 °C (P50, 24.4 °C), river discharge 65–314m3 s 1 (P50, 84m3 s 1), during the dark at 00:00–05:00 h and during both the waxing and waning phases of moonlight. From 396 eels tagged and released 0.3 km downstream of the Lixhe dam, 6.8% of them were recaptured, and 37.4% were detected. Migration flux was estimated at 7184 eels (0.863 t) using the markrecapture method and decreased to 1156 eels (0.139 t) using automatic transponder detection. Most eels probably migrated through a sluice located downstream of Lixhe to reach the upper Meuse via the Albert Canal. Eels moved almost independently to the configuration of the fish passes and their location, but most eels displayed fidelity to the fish pass where they were captured. Migrant eels showed a wide range of size and life stages, with a higher proportion of eels (80%) belonging to the yellow eel stage. A lower proportion of eels (6%) had a larger size and presented an advanced continental silvering process corresponding to the migrating stage before their transatlantic migration. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailConcordance between iohexol and iothalamate plasma clearance
DELANAYE, Pierre ULg; JOURET, François ULg; LE GOFF, Caroline ULg et al

in American Journal of Kidney Diseases (2016)

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailEfficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys.
Bruyère, Olivier ULg; Altman, R.D.; Reginster, Jean-Yves ULg

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 12-17

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) treatment algorithm recommends chronic symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) including glucosamine sulfate (GS) and chondroitin sulfate (CS) as first-line therapy for knee osteoarthritis (OA). Numerous studies are published on the use of SYSADOAs in OA; however, the efficacy of this class is still called into question largely due to the regulatory status, labeling and availability of these medications which differ substantially across the world. Examination of the evidence for the prescription patented crystalline GS (pCGS) formulation at a dose of 1500 mg once-daily demonstrates superiority overother GS and glucosamine hydrochloride (GH) formulations and dosage regimens. Thus, the ESCEO task force advocates differentiation of prescription pCGS over other glucosamine preparations. Long-term clinical trials andreal-life studies show that pCGS may delay joint structural changes, suggesting potential benefit beyond symptom control when used early in the management of knee OA. Real-life pharmacoeconomic studies demonstrate a long-term reduction in the need for additional pain analgesia and non-steroidal anti-inflammatory drugs (NSAIDs) with pCGS, with a significant reduction of over 50% in costs associated with medications, healthcare consultations and examinations over 12 months. Furthermore, treatment with pCGS for at least 12 months leads to a reduction in the need for total joint replacement for at least 5 years following treatment cessation. Thus, pCGS(1500 mg od) is a logical choice to maximize clinical benefit in OA patients, with demonstrated medium-term control of pain and lasting impact on disease progression. [less ▲]

Detailed reference viewed: 16 (7 ULg)
Full Text
Peer Reviewed
See detailVegetation classification and biogeography of European floodplain forests and alder carrs
Douda, Jan; Boublik, Karel; Slezak, Michal et al

in Applied Vegetation Science (2016)

Aim: Formalized classifications synthesizing vegetation data at the continental scale are being attempted only now, although they are of key importance for nature conservation planning. Therefore, we aim ... [more ▼]

Aim: Formalized classifications synthesizing vegetation data at the continental scale are being attempted only now, although they are of key importance for nature conservation planning. Therefore, we aim to provide a vegetation classification and to describe the main iogeographical patterns of floodplain forests and alder carrs in Europe. Location: Europe. Methods: A database of more than 40 000 vegetation plots of floodplain forests and alder carrs across Europe was compiled. After geographic stratification, 16 392 plots were available for classification, which was performed using the supervised method Cocktail. We also searched for new associations using semi-supervised K-means classification. The main biogeographic patterns and climate-related gradients in species composition were determined using detrended correspondence analysis and cluster analysis. Results: Thirty associations of floodplain forests and alder carrs were distinguished, which belong to five alliances. The Alnion incanae includes riparian, seepage and hardwood floodplain forests in the nemoral and hemiboreal zones (dominated by Alnus glutinosa and Fraxinus excelsior) and in the boreal zone (dominated by A. incana). The Osmundo-Alnion represents oceanic vegetation dominated by Alnus glutinosa, Fraxinus angustifolia and F. excelsior distributedmostly on the Iberian Peninsula and composed of species with Atlantic distribution and Iberian endemics. The Populion albae comprises floodplain forests frequently dominated by Fraxinus angustifolia, Populus alba and P. nigra that arewidespread in floodplains of large rivers under summer-dry climates in the Mediterranean region. The Platanion orientalis represents easternMediterranean floodplain forests dominated by Platanus orientalis. The Alnion glutinosae includes forest swamps dominated by Alnus glutinosa distributed mostly in the nemoral and hemiboreal zones. The main biogeographic patterns within European floodplain forests and alder carrs reflect the climatic contrasts between the Mediterranean, nemoral, boreal andmountain regions. Oceanic floodplain forests differ fromthose in the rest of Europe. The hydrological regime appears to be themost important factor influencing species compositionwithin regions. Conclusions: This study is the first applying a formalized classification at the association level for a broad vegetation type at the continental scale. The proposed classification provides the scientific basis for the necessary improvement of the habitat classification systems used in European nature conservation. [less ▲]

Detailed reference viewed: 37 (10 ULg)
Full Text
Peer Reviewed
See detailModular Diversification of the Locomotor System in Damselfishes (Pomacentridae)
Aguilar-Medrano, Rosalia; Frederich, Bruno ULg; Barber, Paul H.

in Journal of Morphology (2016)

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have ... [more ▼]

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have inhabited coral reef ecosystems for more than 50 million years. As such, habitat preferences and behavior could significantly constrain the morphology and evolvability of the locomotor system. To test this hypothesis, we used phylogenetic comparative methods on morphometric, ecological and behavioral data. While body elongation represented the primary source of variation in the locomotor system of damselfishes, results also showed a diverse suite of morphological combinations between extreme morphologies. Results show clear associations between behavior, habitat preferences, and morphology, suggesting ecological constraints on shape diversification of the locomotor system. In addition, results indicate that the three modules of the locomotor system are weakly correlated, resulting in versatile and independent characters. These results suggest that Pomacentridae is shape may result from the interaction between (1) integrated parts of morphological variation that main- tain overall swimming ability and (2) relatively independent parts of the morphology that facilitate adaptation and diversification. [less ▲]

Detailed reference viewed: 13 (4 ULg)
Full Text
Peer Reviewed
See detailImpact of feeding and housing on the development ofosteochondrosis in foals—A longitudinal study
Mendoza García, Luis ULg; Lejeune, Jean-Philippe ULg; Caudron, Isabelle ULg et al

in Preventive Veterinary Medicine (2016), 127

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of ... [more ▼]

Osteochondrosis dissecans (OCD) is a developmental orthopedic disease caused by a failure of the endochondral ossification in epiphyseal plates and joint cartilage. This trouble may induce the presence of osteochondral fragments in the articulation, fissures or subchondral bone cysts in the growth cartilage. Occurrence of osteochondrosis is influenced by a complex interaction of different factors. Among these, the effect of the housing and the feeding of the foals during their first months of life, have been described as risk factors for the development of osteochondrosis. The aim of this study was to investigate the evolution of OCD lesions with a longitudinal study in 204 young foals from 6 to 18 months in comparison to the type of feeding and the type of housing conditions. These factors and OCD status were obtained by a questionnaire and radiological examination, respectively. This allowed dividing the foals into four groups according to the initial OCD status and the evolution of the condition. As a result, we found that foals fed with concentrates show a higher probability to develop OCD lesions (p = 0.06), while foals not receiving concentrates, had a higher probability to heal from existing OCD lesions (p = 0.001). This study supports the theory that management factors such as feeding or housing may influence the evolution of the osteochondrosis disease. [less ▲]

Detailed reference viewed: 22 (3 ULg)
Full Text
Peer Reviewed
See detailBott type periodicity for the higher octonions
Kreusch, Marie ULg

in Journal of Noncommutative Geometry (2016), 9(4), 1041-1393

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions ... [more ▼]

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions and Clifford algebras. The algebras $\bbO_{n}$ and $\bbO_{p,q}$ with $p+q=n$ have a natural $\Z_2^n$-grading, and they are characterized by cubic forms over the field $\Z_2$. We establish a periodicity for the algebras~$\bbO_{n}$ and $\bbO_{p,q}$ similar to that of the Clifford algebras $\mathrm{Cl}_{n}$ and~$\mathrm{Cl}_{p,q}$. [less ▲]

Detailed reference viewed: 146 (48 ULg)
Full Text
Peer Reviewed
See detailGenotyping and strain distribution of Mycobacterium avium subspecies hominissuis isolated from humans and pigs in Belgium, 2011-2013
Vluggen, C; Soetaert, K; Duytschaever, L et al

in Eurosurveillance (2016), 21(3), 18-25

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailHow much does the Dallas Pain Questionnaire score have to improve to indicate that patients with chronic low back pain feel better or well?
Marty, M; Courvoisier, D; Foltz, V et al

in European Spine Journal (2016), 25

Purpose: The Dallas Pain Questionnaire (DPQ) assesses the impact of low back pain (LBP) on four components (0–100) of daily life. We estimated the minimal clinically important improvement (MCII) and the ... [more ▼]

Purpose: The Dallas Pain Questionnaire (DPQ) assesses the impact of low back pain (LBP) on four components (0–100) of daily life. We estimated the minimal clinically important improvement (MCII) and the patient acceptable symptom state (PASS) values of DPQ in LBP patients. Methods: 142 patients with LBP lasting for at least 4 weeks completed a battery of questionnaires at baseline and 6 months later. Questions for MCII addressed patientreported response to treatment at 6 months on a five-point Likert scale, while a yes/no question concerning satisfaction with present state was used to determine PASS. MCII wascomputed as the difference in mean DPQ scores between patients reporting treatment as effective vs. patients reporting treatment as not effective, and PASS was computed as the third quartile of the DPQ score among patients who reported being satisfied with their present state. Results: MCII values were 22, 23, 2 and 10 for daily activities, work and leisure, social interest, and anxiety/depression, respectively. PASS values were 29, 23, 20 and 21 for the four components, respectively. The PASS total score threshold of 24 correctly classified 84.1 % of the patients who reported being unsatisfied with their present state, and 74.7 % of patients reported being satisfied. Conclusions: These values give information of paramount importance for clinicians in interpreting change in DPQ values over time. Authors should be encouraged to report the percentage of patients who reach MCII and PASS values in randomized clinical trials and cohort studies to help clinicians to interpret clinical results. [less ▲]

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailPeripheral blood stem cell graft compared to bone marrow after reduced intensity conditioning regimens for acute leukemia–A report from the ALWP of the EBMT
Savani, Bipin N.; Labopin, Myriam; Blaise, Didier et al

in Haematologica (2016)

Increasing numbers of patients are receiving reduced-intensity-conditioning regimen allogeneic hematopoietic stem-cell transplantation. We hypothesized that the use of bone-marrow graft might decrease the ... [more ▼]

Increasing numbers of patients are receiving reduced-intensity-conditioning regimen allogeneic hematopoietic stem-cell transplantation. We hypothesized that the use of bone-marrow graft might decrease the risk of graft-versus-host-disease compared to peripheral-blood after reduced-intensity-conditioning regimens without compromising graft-versus-leukemia effects. Patients who underwent reduced-intensity-conditioning regimen allogeneic hematopoietic stem-cell transplantation from 2000-2012 for acute leukemia and reported to the acute-leukemia-working-party of the EBMT were included in the study. Eight hundred thirty-seven patients receiving bone-marrow grafts were compared with 9011 peripheral-blood transplant recipients after reduced-intensity conditioning regimen. Median follow-up of surviving patients was 27 months. Cumulative incidence of engraftment (neutrophil≥0.5x109/L at day 60) was lower in bonemarrow recipients, 88 vs. 95% (p<0.0001). Grade II to IV acute graft-versus-hostdisease was lower in bone-marrow recipients, 19% vs. 24% for peripheral-blood (p=0.005). In multivariate analysis, after adjusting for differences between both groups, overall survival (HR 0.90; p=0.05) and leukemia-free-survival (HR 0.88; p=0.01) were higher in patients transplanted with peripheral-blood compared to bone-marrow grafts. Furthermore, peripheral-blood graft was also associated with decreased risk of relapse (HR 0.78; p=0.0001). Non-relapse-mortality was not significantly different between recipients of bone-marrow and peripheral-blood grafts, and chronic graft-versus-host-disease was significantly higher after peripheral blood grafts (HR 1.38; p<0.0001). Despite the limitation of a retrospective registry based study, we found that peripheral-blood grafts after reduced-intensity-conditioning regimens had better overall and leukemia-free survival than bone-marrow grafts. However, there is an increase in chronic graft-versus-host-disease after peripheral-blood grafts. Long-term follow-up is needed to clarify if chronic graft-versus-host-disease related deaths might increase the risk of late morbidity and mortality. [less ▲]

Detailed reference viewed: 14 (2 ULg)
Full Text
Peer Reviewed
See detailCreatinine-based equations for the adjustment of drug dosage in an obese population.
BOUQUEGNEAU, Antoine ULg; Vidal-Petiot, E; Moranne, O et al

in British Journal of Clinical Pharmacology (2016), 81(2), 349-361

Detailed reference viewed: 26 (13 ULg)
Full Text
Peer Reviewed
See detailSPICAM observations and modeling of Mars aurorae
Soret, Lauriane ULg; Gérard, Jean-Claude ULg; Libert, Ludivine ULg et al

in Icarus (2016), 264

Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the ... [more ▼]

Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the altitudes and the intensities of the auroral emissions. The CO (a3P–X1R) Cameron bands between 190 and 270 nm, the CO Fourth Positive system (CO 4P) between 135 and 170 nm, the CO2+ doublet at 289 nm, the OI at 297.2 nm and the 130.4 nm OI triplet emissions have been identified in the spectra and in the time variations of the signals. The intensities of these auroral emissions have been quantified and the altitude of the strongest emission of the CO Cameron bands has been estimated to be 137 ± 27 km. The locations of these auroral events have also been determined and correspond to the statistical boundary of open-closed magnetic field lines, in cusp-like structures. The observed altitudes of the auroral emissions are reproduced by a Monte-Carlo model of electron transport in the Martian thermosphere for mono-energetic electrons between 40 and 200 eV. No correlation between electron fluxes measured in the upper thermosphere and nadir auroral intensity has been found. Here, we simulate auroral emissions observed both at the limb and at the nadir using electron energy spectra simultaneously measured with the ASPERA-3/ELS instrument. The simulated altitudes are in very good agreement with the observations. We find that predicted vertically integrated intensities for the various auroral emissions are overestimated, probably as a consequence of the inclination and curvature of the magnetic field line threading the aurora. However, the relative brightness of the CO and CO2+ emissions is in good agreement with the observations. [less ▲]

Detailed reference viewed: 39 (12 ULg)
Full Text
Peer Reviewed
See detailImpact of climatic factors on the release of E-β-caryophyllene from alginate beads
Daems, Frédéric ULg; Bera, François ULg; Lorge, Stéphanie ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2),

Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little ... [more ▼]

Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little information, however, is available about the impact of climatic factors on the release of semiochemicals from this diffusive system. Objectives. The objective of this scoping study was to investigate the impact of temperature, relative humidity and wind speed, on the release of E-β-caryophyllene from alginate beads. Method. The impact of the three climatic factors on the release of E-β-caryophyllene from alginate beads was evaluated using a Box-Behnken experimental design and a laboratory scale volatile collection system. The influence of relative humidity on bead water content and size, with and without this semiochemical, was also investigated using a gravimetric method and an easy-to-use photographic device, respectively. Results. The results showed that an increase in temperature caused a significant increase in the E-β¬-caryophyllene release rate. Neither relative humidity nor airflow, however, had a significant effect on the release of this semiochemical when relative humidity and wind speed ranged from 33% to 75% and from 6.61 x10-4 m.s-1 to 2.05 x10-2 m.s-1, respectively. The isotherm curves obtained were characteristic of food products and biopolymer materials. The isotherm shapes were not modified by the incorporation of the semiochemical into alginate beads, and showed an important increase in water content when relative humidity values exceeded 85%. Fortunately, this water content increase did not affect bead size, which facilitates the calculation of E-β-caryophyllene release. Conclusion. The present study shows for the first time the impact of the three main climatic factors on the release of E-β-caryophyllene from alginate beads. It allows learning more about how these biological control devices operate in order to optimize future field trials. [less ▲]

Detailed reference viewed: 31 (3 ULg)
Full Text
Peer Reviewed
See detailInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al

in Lancet (2016)

Detailed reference viewed: 641 (15 ULg)
Full Text
Peer Reviewed
See detailKinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35.
Marcoccia, Francesca; Bottoni, Carlo; Sabatini, Alessia et al

in Antimicrobial agents and chemotherapy (2016), 60(4), 2366-72

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized ... [more ▼]

Two laboratory mutants of NDM-1 were generated by replacing the isoleucine at position 35 with threonine and serine residues: the NDM-1(I35T)and NDM-1(I35S)enzymes. These mutants were well characterized, and their kinetic parameters were compared with those of the NDM-1 wild type. Thekcat,Km, andkcat/Kmvalues calculated for the two mutants were slightly different from those of the wild-type enzyme. Interestingly, thekcat/Kmof NDM-1(I35S)for loracarbef was about 14-fold higher than that of NDM-1. Far-UV circular dichroism (CD) spectra of NDM-1 and NDM-1(I35T)and NDM-1(I35S)enzymes suggest local structural rearrangements in the secondary structure with a marked reduction of alpha-helix content in the mutants. [less ▲]

Detailed reference viewed: 15 (3 ULg)
Full Text
Peer Reviewed
See detailcompte rendu de : Lenglet-Dufresnoy, Écrits inédits sur le roman. Édité par J. Herman et J. Cormier. Oxford, Voltaire Foundation, 2014.
Decoster, Sara ULg

in Revue d'Histoire Littéraire de la France (2016), 116(1), 222-224

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailOptimization of a cheap and residential small-scale production of edible crickets with local by-products as an alternative protein-rich human food source in Ratanakiri Province (Cambodia)
Caparros Megido, Rudy ULg; Alabi, Taofic ULg; Nieus, Clément et al

in Journal of the Science of Food and Agriculture (2016)

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may ... [more ▼]

Background - Health status of the indigenous people of the Ratanakiri Province, Cambodia, is significantly lower compared to the rest of the nation. The domestication and mass production of insects may represent a sustainable, cost effective and high quality alternative source of protein to traditional livestock. This study aimed to optimise a cheap and residential cricket breeding system based on unused wild resources. The cricket development, Teleogryllus testaceus (Walker), under seven diets composed of taro aerial parts, young cassava leaves, young cashew leaves and brown rice flour (with or without banana slices), versus a traditionally used broiler feed diet was studied. Results - Cricket mortality was low in all diets, except the two cashew-based diets. Total biomass was significantly higher under the broiler feed, in addition to the two diets containing a combination of cassava leaf powder and brown rice. Yet, crickets fed with the taro diet had the highest percentage of protein. Concerning the breeding system cost, units using cassava leaves were the cheapest ones. Conclusion – Diets based of cassava leaves seems to be the most promising ones. Nevertheless, to produce crickets with a high body mass and a high protein level, a new experiment must be realised in which the cassava leaf maturity will be adapted to fit with the cricket growth stage. Moreover, to reduce the cost of the breeding units, handmade local products should be used instead of purchased components. [less ▲]

Detailed reference viewed: 74 (29 ULg)
Full Text
Peer Reviewed
See detailBarley (Hordeum distichon L.) roots synthesise volatile aldehydes with a strong age-dependent pattern and release (E)- non-2-enal and (E,Z)-nona-2,6-dienal after mechanical injury
Delory, Benjamin M.; Delaplace, Pierre ULg; du Jardin, Patrick ULg et al

in Plant Physiology and Biochemistry (2016), 104

In the context of chemical ecology, the analysis of the temporal production pattern of volatile organic compounds (VOCs) in root tissues and the emission rate measurement of root-emitted VOCs are of major ... [more ▼]

In the context of chemical ecology, the analysis of the temporal production pattern of volatile organic compounds (VOCs) in root tissues and the emission rate measurement of root-emitted VOCs are of major importance for setting up experiments to study the implication of these compounds in biotic interactions. Such analyses, however, remain challenging because of the belowground location of plant root systems. In this context, this study describes the evolution of the root VOC production pattern of barley (Hordeum distichon L.) at five developmental stages from germination to the end of tillering and evaluates the emission of the identified VOCs in an artificial soil. VOCs produced by crushed root tissues and released by unexcavated root systems were analysed using dynamic sampling devices coupled to a gas chromatography-mass spectrometry methodology (synchronous SCAN/SIM). The results showed that, at each analysed developmental stage, crushed barley roots produced mainly four volatile aldehydes: hexanal; (E)-hex-2-enal; (E)-non-2-enal; and (E,Z)-nona-2,6-dienal. Higher total and individual VOC concentrations were measured in 3-day-old seminal roots compared with older phenological stages. For each developmental stage, the lipoxygenase (LOX) activity was greater for linoleic acid than α-linolenic acid and the greatest LOX activities using linoleic and α- linolenic acids as substrates were measured in 7- and 3-day-old roots, respectively. The analysis of VOCs released by barley roots into the soil showed that (E)-non-2- enal and (E,Z)-nona-2,6-dienal were the only VOCs emitted in quantifiable amounts by mechanically injured roots. [less ▲]

Detailed reference viewed: 19 (7 ULg)
Full Text
Peer Reviewed
See detailPassive acoustic recording of Ophidion rochei calling activity in Calvi Bay (France)
Kever, Loïc ULg; Lejeune, Pierre; Michel, Loïc ULg et al

in Marine Ecology (2016)

Passive acoustic recording (PAR) systems are non-invasive and allow researchers to collect data on large spatial and temporal scales. Since fish sounds are species-specific and repetitive, PAR can provide ... [more ▼]

Passive acoustic recording (PAR) systems are non-invasive and allow researchers to collect data on large spatial and temporal scales. Since fish sounds are species-specific and repetitive, PAR can provide a large amount of data about spatio-temporal variation in fish distribution and behaviors. Ophidion rochei is a sand-dwelling species from Mediterranean and Black Sea meaning the behavior of this discreet nocturnal fish cannot be observed in the field. Fortunately, male O. rochei produce long multiple-pulsed calls that are easy to identify. The aim of this study was to determine that male calls are linked to reproduction behaviors. If so, PAR would allow a fine description of the seasonal and daily cycles in O. rochei reproduction. A hydrophone was deployed from 18 July 2011 to 21 June 2012 and from 7 June 2013 to 2 July 2013 on a sandy area (42.5801° N, 8.7285° E) in front of the STARESO research station (NW Corsica). Male sounds were obtained only at night from late spring to early fall. The annual sound production period corresponds to the reproductive season of O. rochei. Sound production followed diel cycles: it was sustained for the entire night at the beginning of the sound production season but limited to shorter periods in the evening during the second half of the season. These differences in daily and seasonal sound production tempo can be used in future recordings to make inter-annual comparisons and estimate the physiological state of the fish. [less ▲]

Detailed reference viewed: 44 (16 ULg)
Full Text
Peer Reviewed
See detailRecommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean-Yves ULg; Cooper, Cyrus; Rizzoli, René et al

in Aging Clinical and Experimental Research (2016), 28(1), 47-58

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]

Detailed reference viewed: 22 (6 ULg)
Full Text
Peer Reviewed
See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

Detailed reference viewed: 36 (5 ULg)
Full Text
Peer Reviewed
See detailCorrelation between ethanol behavioral sensitization and midbrain dopamine neuron reactivity to ethanol
Didone, Vincent ULg; Masson, Sébastien; Quoilin, Caroline et al

in Addiction Biology (2016), 21(2), 387-396

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral ... [more ▼]

Repeated ethanol injections lead to a sensitization of its stimulant effects in mice. Some recent results argue against a role for ventral tegmental area (VTA) dopamine neurons in ethanol behavioral sensitization. The aim of the present study was to test whether in vivo ethanol locomotor sensitization correlates with changes in either basal- or ethanol evoked firing rates of dopamine neurons in vitro. Female Swiss mice were daily injected with 2.5 g/kg ethanol (or saline in the control group) for 7 days and their locomotor activity was recorded. At the end of the sensitization procedure, extracellular recordings were made from dopaminergic neurons in midbrain slices from these mice. Significantly higher spontaneous basal firing rates of dopamine neurons were recorded in ethanol-sensitized mice relative to control mice, but without correlations with the behavioral effects. The superfusion of sulpiride, a dopamine D2 antagonist, induced a stronger increase of dopamine neuron firing rates in ethanol-sensitized mice. This shows that the D2 feedback in dopamine neurons is preserved after chronic ethanol administration and argues against a reduced D2 feedback as an explanation for the increased dopamine neuron basal firing rates in ethanol-sensitized mice. Finally, ethanol superfusion (10–100 mM) significantly increased the firing rates of dopamine neurons and this effect was of higher magnitude in ethanol-sensitized mice. Furthermore, there were significant correlations between such a sensitization of dopamine neuron activity and ethanol behavioral sensitization. These results support the hypothesis that changes in brain dopamine neuron activity contribute to the behavioral sensitization of the stimulant effects of ethanol. [less ▲]

Detailed reference viewed: 39 (13 ULg)
Full Text
Peer Reviewed
See detailAn Improved Molecular Histology Method for Ion Suppression Monitoring and Quantification of Phosphatidyl Cholines During MALDI MSI Lipidomics Analyses.
Jadoul, Laure ULg; Smargiasso, Nicolas ULg; Pamelard, Fabien et al

in OMICS : A Journal of Integrative Biology (2016), 20(2), 110-21

Tissue lipidomics is one of the latest omics approaches for biomarker discovery in pharmacology, pathology, and the life sciences at large. In this context, matrix-assisted laser desorption/ionization ... [more ▼]

Tissue lipidomics is one of the latest omics approaches for biomarker discovery in pharmacology, pathology, and the life sciences at large. In this context, matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is the most versatile tool to map compounds within tissue sections. However, ion suppression events occurring during MALDI MSI analyses make it impossible to use this method for quantitative investigations without additional validation steps. This is especially true for lipidomics, since different lipid classes are responsible for important ion suppression events. We propose here an improved lipidomics method to assess local ion suppression of phospatidylcholines in tissues. Serial tissue sections were spiked with different amounts of PC(16:0 d31/18:1) using a nebulization device. Settings for standard nebulization were strictly controlled for a detection similar to when using spiked tissue homogenates. The sections were simultaneously analyzed by MALDI MSI using a Fourier transform ion cyclotron resonance analyzer. Such a spray-based approach allows taking into account the biochemical heterogeneity of the tissue for the detection of PC(16:0 d31/18:1). Thus, here we present the perspective to use this method for quantification purposes. The linear regression lines are considered as calibration curves and we calculate PC(16:0/18:1) quantification values for different ROIs. Although those values need to be validated by a using a different independent approach, the workflow offers an insight into new quantitative mass spectrometry imaging (q-MSI) methods. This approach of ion suppression monitoring of phosphocholines in tissues may be highly interesting for a large range of applications in MALDI MSI, particularly for pathology using translational science workflows. [less ▲]

Detailed reference viewed: 86 (6 ULg)
Full Text
Peer Reviewed
See detailHDAC7 inhibition resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN: new opportunities for selected targeted therapies
Peixoto, Paul; Blomme, Arnaud; Costanza, Brunella ULg et al

in Oncogene (2016)

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 ... [more ▼]

To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 patients and have identified a strong positive correlation between STAT3 and HDAC7 expression. In the current work we show the existence of a subpopulation of patients overexpressing HDAC7 and STAT3 that has particularly poor clinical outcome. Surprisingly, the somatic mutation rate of both STAT3 and HDAC7 was insignificant in GBM comparing with EGFR, PTEN or TP53. Depletion of HDAC7 in a range of GBM cells induced the expression of tyrosine kinase JAK1 and the tumor suppressor AKAP12. Both proteins synergistically sustained the activity of STAT3 by inducing its phosphorylation (JAK1) and protein expression (AKAP12). In absence of HDAC7, activated STAT3 was responsible for significant imbalance of secreted pro-/anti-angiogenic factors. This inhibited the migration and sprouting of endothelial cells in paracrine fashion in vitro as well as angiogenesis in vivo. In a murine model of GBM, induced HDAC7-silencing decreased the tumor burden by threefold. The current data show for the first time that silencing HDAC7 can reset the tumor suppressor activity of STAT3, independently of the EGFR/PTEN/TP53 background of the GBM. This effect could be exploited to overcome tumor heterogeneity and provide a new rationale behind the development of specific HDAC7 inhibitors for clinical use. [less ▲]

Detailed reference viewed: 22 (9 ULg)
Full Text
Peer Reviewed
See detailLa correction de l’expression écrite en langue étrangère et son exploitation pédagogique. Expliciter l’implicite ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2016)

Detailed reference viewed: 57 (20 ULg)
Full Text
Peer Reviewed
See detailThermosensitivity of the sex differentiation process in the African catfish, Clarias gariepinus: Determination of the thermosensitive period
Santi, Saïdou ULg; Gennotte, Vincent ULg; Toguyeni, Aboubacar et al

in Aquaculture (2016), 455

Gonadal sex differentiation in gonochoristic fish is generally labile and under the control of two interacting processes: genetic sex determination (GSD) and environmental sex determination (ESD ... [more ▼]

Gonadal sex differentiation in gonochoristic fish is generally labile and under the control of two interacting processes: genetic sex determination (GSD) and environmental sex determination (ESD). Numerous experimental studies deal with temperature induced-sex differentiation in teleosts, but none focused on the African catfish Clarias gariepinus. The aim of this study was to confirm the thermosensitivity of the sex differentiation process and to determine the thermosensitive period during the African catfish development. Fish were exposed to high temperature (36 °C) for 3 days at different periods during ontogenesis. The treatment was applied every 3 days from fertilization until 29 days post-hatching (dph). Before and after the thermal treatment, fish were reared at 28 °C. Gonadal development was histologically characterized on fish sampled at 10, 15, 20, 25, 35, 45, 55 and 70 dph. Our results demonstrated that the African catfish displays a thermosensitivity of the sex differentiation process, with a masculinizing effect of high temperature (36 °C). The most thermosensitive period extended from 6 to 8 dph. Fish batches exposed to 36 °C during this period showed a sex-ratio skewed towards the male phenotype, ranging from 58 to 100% (high inter-familial variability). The African catfish gonads (male and female) stayed histologically undifferentiated until 20 dph. Obvious signs of gonadal differentiation clearly appeared at 25 dph in females and at 45 dph in males. Variability in sex-ratios between progenies and in the response to thermal treatment suggests a role of minor genetic factors and interactions between genomic and environmental determinants in the expression of the sexual phenotype. Statement of relevance: 1. This paper provides novel methods to control African catfish Clarias gariepinus sex differentiation through high temperature exposure and then to produce all-male populations. 2. Our work underlines the possibility to significantly reduce high temperature (masculinizing effect) treatment period to 3 days and consequently increase survival rate of progenies after treatment. 3. This study also shows the inter-family variability of thermosensitivity on the sex differentiation process in Clarias gariepinus. [less ▲]

Detailed reference viewed: 25 (8 ULg)
Full Text
Peer Reviewed
See detailFarmers’ Perception and Willingness to Pay for Climate Information in Burkina Faso
Zongo, Bétéo ULg; Diarra, Abdoulaye; Barbier, Bruno et al

in Journal of Agricultural Science (2016), 8

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access ... [more ▼]

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access to climate information, while 93% of them need climate information to guide through their decision in planning agricultural activities. Option value shows the interest granted by farmers using climate information. About 64% of the farmers are willing to pay an average of Francs CFA 546.34 to obtain climate information. The willingness to pay is determined by the the farmers’ ability to predict the climate, to use radio as a means of information, farmers’ awareness of previous forecasts and early onset of rainy season. While farmers considered benefits from the use of climate information, it is clear that its contribution to farm income remains a field of research to explore. Thus it is necessary to experiment with individual farms and to evaluate the contribution of climate information to the value added in different crops and farmers’ income. [less ▲]

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detail2015 ESC Guidelines for the management of infective endocarditis.
Habib, Gilbert; LANCELLOTTI, Patrizio ULg; Antunes, Manuel J. et al

in Revista espanola de cardiologia (English ed.) (2016), 69(1), 69

Detailed reference viewed: 17 (2 ULg)
Full Text
Peer Reviewed
See detailRecent advances in composite CAD/CAM blocks.
Mainjot, Amélie ULg

in International Journal of Esthetic Dentistry (2016), 11(2), 275-80

Detailed reference viewed: 8 (2 ULg)
Full Text
Peer Reviewed
See detailSupplementation of transport and freezing media with anti-apoptotic drugs improves ovarian cortex survival
HENRY, Laurie ULg; Fransolet, Maïté ULg; LABIED, Soraya ULg et al

in Journal of Ovarian Research (2016)

Background: Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation ... [more ▼]

Background: Ovarian tissue preservation is proposed to patients at risk of premature ovarian failure, but this procedure still needs to be optimized. To limit injury during ovarian tissue cryopreservation, anti-apoptotic drugs were added to the transport and freezing media of ovarian cortex tissue. Methods: Sheep ovaries were transported, prepared and frozen in solutions containing vehicle or anti-apoptotic drugs (Z-VAD-FMK, a pan-caspase inhibitor, or sphingosine-1-phosphate (S1P), a bioactive lipid). After the tissue was thawed, the ovarian cortex was cultured for 2 or 6 days. Follicular quantification and morphological and proliferation analyses were performed on histological sections. Results: After 2 days of culture, S1P improved the quality of primordial follicles; higher densities of morphologically normal and proliferative primordial follicles were found. Z-VAD-FMK displayed similar effects by preserving global primordial follicular density, but this effect was evident after 6 days of culture. This drug also improved cell proliferation after 2 and 6 days of culture. Conclusions: Our results showed that the addition of S1P or Z-VAD-FMK to the transport and freezing media prior to ovarian tissue cryopreservation improves primordial follicular quality and therefore improves global tissue survival. This should ultimately lead to improved fertility restoration after auto-transplantation. [less ▲]

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailSafety in Long Term Radioactive Waste Management: Insight and Oversight
Schröder, Jantine; Rossignol, Nicolas ULg; Van Oudheusden, Michiel ULg

in Safety Science (2016), 85

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable ... [more ▼]

High-level, long-lived radioactive waste remains hazardous for periods that go well beyond our human conception of time (many thousands of years). Because active safety measures are considered unreliable, unjustifiable and simply impossible over such long time spans, experts worldwide recommend geological disposal as the preferred strategy for long-term radioactive waste management, to a large extent due to its promise of delivering ‘passive safety’. Passive safety refers to the repository being safe ‘by itself’, i.e. unmediated by human actors and actions. Safety is thus approached technically and delineated as an intrinsic property of the disposal system. As such, the notion of 'passive safety' entails a system simplification that allows for approaching safety in a more calculable and predictable manner than would be the case for 'active safety'. In this article, we describe and analyze the ambiguity of this seemingly straightforward approach to safety. Drawing on constructivist insights from safety science and science and technology studies, we propose a more integrated sociotechnical vision that transcends the active versus passive safety division. The notion of 'oversight', as it is currently starting to surface in international radioactive waste management discourses, will be used as a sensitizing concept, offering potential to elaborate such an integrated vision. [less ▲]

Detailed reference viewed: 37 (2 ULg)
Full Text
Peer Reviewed
See detailResponse to novely and cocaine stimulant effects: lack of stability across environments in female Swiss mice
Nyssen, Laura ULg; Brabant, Christian ULg; Didone, Vincent ULg et al

in Psychopharmacology (2016), 233

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model ... [more ▼]

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model novelty seeking is the "response to novelty," i.e., the levels of locomotor activity in a new environment. In rodents, a positive correlation was demonstrated between the response to novelty and several effects of drugs, especially the locomotor stimulant effects of cocaine. Objectives: The present study was designed to test in mice whether the response to novelty is stable across environments and whether its relationship with the stimulant effects of cocaine is altered by environmental changes. Experiment 1 assessed the responses to novelty of the same mice in two different novel environments. Experiment 2 tested the correlation between response to novelty and acute stimulant effects of cocaine recorded in two distinct environments. Results: The results show a weak correlation only during the first 5 min of the session between the responses to novelty measured in two distinct environments. Experiment 2 demonstrates that novelty responses and stimulant effects of cocaine are positively correlated only when both behavioral responses are measured in the same environment. In contrast, the relationship between response to novelty and acute stimulant effects of cocaine is completely lost when the behavioral responses are recorded in two different environments. Conclusions: The present results question the usual interpretation of the correlation between the response to novelty and the stimulant effects of cocaine as reflecting a relationship between two underlying individual stable characteristics. [less ▲]

Detailed reference viewed: 10 (3 ULg)
Full Text
Peer Reviewed
See detailLongitudinal Study of Growth and Osteoarticular Status in Foals Born to Between-Breed Embryo Transfers
Peugnet, Pauline; Mendoza García, Luis ULg; Wimel, Laurence et al

in Journal of Equine Veterinary Science (2016), 37

The role of antenatal events on growth and predisposition to osteochondrosis (OC) was investigated in foals born to between-breed embryo transfers. Pony (P), saddlebred (S), and draft (D) horses were used ... [more ▼]

The role of antenatal events on growth and predisposition to osteochondrosis (OC) was investigated in foals born to between-breed embryo transfers. Pony (P), saddlebred (S), and draft (D) horses were used. Control P-P (n ¼ 21) and S-S (n ¼ 28) pregnancies were obtained by artificial insemination. Enhanced and restricted pregnancies were obtained by transferring P or S embryos into D mares (P-D, n ¼ 6 and S-D, n ¼ 8) and S embryos into P mares (S-P, n ¼ 6), respectively. Control and experimental foals were raised by their dams and recipient mothers, respectively, and weaned at age 6 months. Body measurements were recorded from birth to age 18 months. Osteochondrosis status was evaluated shortly after weaning and at age 18 months. Fetal growth was enhanced in P-D foals with overgrowth of most body segments until age 18 months. Fetal growth was restricted in S-P foals compared with S-D foals. Body weight, shoulder, and hip width of S-P foals grew slower before weaning but subsequently caught up after weaning. Other segments did not catch up, resulting in reduced body weight and withers’ height in S-P compared with S-D foals at age 18 months. The relative risk of developing OC was increased in restricted S-P foals compared with S-S and S-D foals shortly after weaning where all S-P foals were OC positive. Only two S-P foals were still OC positive at age 18 months. These data confirm the impact of the intrauterine environment on growth, skeletal health, and possibly athletic capacities of horses. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailClinical sentinel surveillance of equine West Nile fever, Spain
Saegerman, Claude ULg; Alba-Casals, A; Garcia-Bocanegra, I et al

in Transboundary and Emerging Diseases (2016), 63(2), 184-193

Detailed reference viewed: 40 (19 ULg)
Full Text
Peer Reviewed
See detailPleiotropic Control by Testosterone of a Learned Vocal Behavior and Its Underlying Neuroplasticity(1,2,3).
Alward, Beau A.; Madison, Farrah N.; Parker, Shannon E. et al

in eNeuro (2016), 3(1),

Steroid hormones coordinate multiple aspects of behavior and physiology. The same hormone often regulates different aspects of a single behavior and its underlying neuroplasticity. This pleiotropic ... [more ▼]

Steroid hormones coordinate multiple aspects of behavior and physiology. The same hormone often regulates different aspects of a single behavior and its underlying neuroplasticity. This pleiotropic regulation of behavior and physiology is not well understood. Here, we investigated the orchestration by testosterone (T) of birdsong and its neural substrate, the song control system. Male canaries were castrated and received stereotaxic implants filled with T in select brain areas. Implanting T solely in the medial preoptic nucleus (POM) increased the motivation to sing, but did not enhance aspects of song quality such as acoustic structure and stereotypy. In birds implanted with T solely in HVC (proper name), a key sensorimotor region of the song control system, little or no song was observed, similar to castrates that received no T implants of any sort. However, implanting T in HVC and POM simultaneously rescued all measures of song quality. Song amplitude, though, was still lower than what was observed in birds receiving peripheral T treatment. T in POM enhanced HVC volume bilaterally, likely due to activity-dependent changes resulting from an enhanced song rate. T directly in HVC, without increasing song rate, enhanced HVC volume on the ipsilateral side only. T in HVC enhanced the incorporation and recruitment of new neurons into this nucleus, while singing activity can independently influence the incorporation of new neurons into HVC. These results have broad implications for how steroid hormones integrate across different brain regions to coordinate complex social behaviors. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailThe Calern Asteroid Polarimetric Survey using the Torino Polarimeter: assessment of instrument performances and first scientific results
Devogele, Maxime ULg; Cellino, Alberto; Bagnulo, Stefano et al

in Monthly Notices of the Royal Astronomical Society (2016)

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C ... [more ▼]

A new polarimeter based on the Wedged double Wollaston concept has been built at the Torino Observatory and installed on a 1-meter telescope at the Calern observing station of the ``Observatoire de la C{\^o}te d'Azur''. Its main purpose is to carry out a polarimetric survey of Solar System objects. This survey is called CAPS (Calern Asteroid Polarimetric Survey). In this paper, the new Torino polarimeter (ToPo) and its preliminary validation campaign is described. The first results of the CAPS survey are also presented. A number of standard stars with known polarization states, as well as a number of asteroids for which the polarimetric properties are known, have been observed in order to assess the instrument accuracy. The instrument response over the field of view and also its stability over single nights and longer periods have also been tested. It has been found that the instrument polarization is stable within a few $10^{-4}$ units. The first polarimetric observations of a still limited number of asteroids show an excellent agreement with previously available data and make already some significant contributions by adding new data to a number of objects that had been poorly observed so far. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailPrevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.
Muysoms, Filip E.; DETRY, Olivier ULg; Vierendeels, Tijl et al

in Annals of surgery (2016), 263(4), 638-645

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]

Detailed reference viewed: 9 (3 ULg)
Full Text
Peer Reviewed
See detailL’adaptation du pervers et du psychopathe : compréhension phénoménologique et éthologique
Englebert, Jérôme ULg

in PSN. Psychiatrie, Sciences Humaines, Neurosciences (2016), 16

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have ... [more ▼]

Our contribution shows that it is possible to conduct a study about psychopathy and perverse personality from the principle of adaptation. We note a social ‘‘hyperadaptation’’ of the pervert. But we have to note that there are moments of mismatch and maladjustment. These ‘‘perverse moments’’ are very important to be observed and regarded as a pathognomonic symptomatology. The specificity of the perverse functioning should be viewed as a continuum of adaptation along which an individual may pass from ‘‘hyperadaptation’’ on the one hand, to moments of failures and mis-adapting on the other hand. Then, we propose a comparison between the binswangerian conception of mania and the psychopathic functioning. The maniac has a fundamental crisis of the ‘‘ego’’, which the psychopath does not have. A second finding of our investigations concerns emotions and the dimension of the adaptive psychopathic disorder. The last point we discuss is about the concepts of empathy and sympathy. Finally, a significant part of this paper is to propose a differentiation concerning adaptive behaviour: one is more social (the pervert); the other is more solitary (the psychopath). [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailManaging Chronic Kidney Disease in Older People--Reply
Glassock, rj; DELANAYE, Pierre ULg; El-Nahas, M

in JAMA : Journal of the American Medical Association (2016), 315(3),

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailDisplacement of an Electrically Charged Drop on a Vibrating Bath
Brandenbourger, Martin ULg; Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in Physical Review Letters (2016), 116

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detailPhénoménologie et grammaire
Leclercq, Bruno ULg; Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2016)

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels ... [more ▼]

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels qui conditionnent la possibilité même de la signification. Husserl par excellence, dans la quatrième Recherche Logique, dégage l’idée d’une grammaire pure régissant les conditions du sens possible (par opposition au non-sens) avant même qu'intervienne la question logique de la consistance (par opposition au contresens). Ce niveau grammatical s’articule autour de catégories de la signification (matière nominale, matière adjectivale, ...) et des lois de leur combinaison, catégories et lois qui peuvent être dégagées par des tests de substituabilité « salva significatione ». Cette idée d’une structure purement grammaticale des significations est aussi explorée par d’autres disciples de Brentano comme Anton Marty, lequel prend part au débat sur la possibilité des « propositions sans sujets » dès ses articles de 1884-1896. Or cette approche formelle de la grammaire qui a réglé l’émergence de la phénoménologie ne va pas sans poser de questions. L’enjeu du numéro est d’interroger le type de formalisme qui est en jeu à l’origine de la phénoménologie pour en préciser les sens et en tester la longévité. La question se pose tout d’abord de savoir si l’hypothèse d’une légalité purement grammaticale est pertinente et quels rapports elle entretiendrait avec 1) la légalité spécifiquement linguistique liée à l'expression de ces significations dans telle ou telle langue ou même dans le langage en général. Les catégories de signification et les lois de leur combinaison précèdent-elles tout langage ? 2) la légalité ontologique qui est celle des objets pensés à travers ces significations. Les objets imposent-ils leur structure aux significations à travers lesquelles on les pense ou, au contraire, les significations imposent-elles leur structure aux objets pensés à travers elles ? 3) la légalité phénoménale qui régit plus particulièrement l'expérience sensible (synthèses passives, etc.). 4) Par ailleurs, on peut se demander si cette légalité grammaticale dégagée par Husserl est purement syntaxique (c’est-à-dire qu’elle se définirait essentiellement par opposition aux combinaisons de signification insensées parce que syntaxiquement mal formées comme « vert est ou ») ou si elle est également sémantique (c’est-à-dire qu’elle se définirait également par opposition aux combinaisons de signification insensées parce qu’absurdes comme « le nombre 2 est vert »). [less ▲]

Detailed reference viewed: 28 (1 ULg)
Full Text
Peer Reviewed
See detailMechanical behaviour of tape springs used in the deployment of reflectors around a solar panel
Dewalque, Florence ULg; Collette, Jean-Paul; Bruls, Olivier ULg

in Acta Astronautica (2016), 123

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this ... [more ▼]

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this work, reflectors are deployed by the means of compliant mechanisms known as tape springs. Their attractive characteristics are, among others, their passive behaviour, their self-locking capacity, their elastic deformations and their robustness. However, their mechanical behaviour is highly nonlinear and requires thorough analyses in order to develop predictive numerical models. It is shown here through parametric studies that the nonlinear behaviour of a tape spring is mainly governed by its geometry. Thus, for each specific application, its dimensions can be determined in order to minimise two critical features: the maximum stress affecting the structure and the maximum motion amplitude during deployment. In this paper, an optimisation procedure is proposed to meet these requirements. [less ▲]

Detailed reference viewed: 24 (11 ULg)
Full Text
Peer Reviewed
See detailOrbitally induced hierarchy of exchange interactions in zigzag antiferromagnetic state of honeycomb silver delafossite Ag3Co2SbO6
Zvereva, E.A.; Stratan, M.I.; Ushakov, A.V. et al

in Dalton Transactions (2016)

We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data ... [more ▼]

We report the revised crystal structure, static and dynamic magnetic properties of quasi-two dimensional honeycomb lattice silver delafossite Ag3Co2SbO6. The magnetic susceptibility and specific heat data are consistent with the onset of antiferromagnetic long range order at low temperatures with Néel temperature TN ~ 21.2 K. In addition, the magnetization curves revealed a field-induced (spin-flop type) transition below TN in moderate magnetic fields. The GGA+U calculations show the importance of the orbital degrees of freedom, which maintain a hierarchy of exchange interaction in the system. The strongest antiferromagnetic exchange coupling was found in the shortest Co-Co pairs and is due to direct and superexchange interaction between the half-filled xz+yz orbitals pointing directly to each other. The other four out of six nearest neighbor exchanges within the cobalt hexagon are suppressed, since for these bonds active half-filled orbitals turned out to be parallel and do not overlap. The electron spin resonance (ESR) spectra reveal a broad absorption line attributed to Co2+ ion in octahedral coordination with average effective g-factor g=2.40±0.05 at room temperature and show strong divergence of ESR parameters below ~ 150 K, which implies an extended region of short-range correlations. Based on the results of magnetic and thermodynamic studies in applied fields, we propose the magnetic phase diagram for the new honeycomb-lattice delafossite. [less ▲]

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detail[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
WITHOFS, Nadia ULg; Martinive, Philippe ULg; VANDERICK, Jean ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]

Detailed reference viewed: 23 (4 ULg)
Full Text
Peer Reviewed
See detailAn ecophysiological discussion of trace element bioaccumulation in cultured Mytilus galloprovincialis
Richir, Jonathan ULg; Gobert, Sylvie ULg

in Belgian Journal of Zoology (2016), 145(1), 53-61

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailA consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis - From evidence-based medicine to the real-life setting.
Bruyère, Olivier ULg; Cooper, C.; Pelletier, J.P. et al

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 3-11

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides practical guidance for the prioritization of interventions. Further analysis of real-world data for OA provides additional evidence in support of pharmacological interventions,in terms of management of OA pain and function, avoidance of adverse events, disease-modifying effects and long-term outcomes, e.g., delay of total joint replacement surgery, and pharmacoeconomic factors such as reduction in healthcare resource utilization. This article provides an updated assessment of the literature for selected interventions in OA, focusing on real-life data, with the aim of providing easy-to-follow advice on how to establish a treatment flow in patients with knee OA in primary care clinical practice, in support of the clinicians’ individualized assessment of the patient. In step 1, background maintenance therapy with symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) is recommended, for which high-quality evidence is provided only for the prescription formulations of patented crystalline glucosamine sulfate and chondroitin sulfate. Paracetamol may be added for rescue analgesia only,due to limited efficacy and increasing safety signals. Topical non-steroidal anti-inflammatory drugs (NSAIDs) may provide additional symptomatic treatment with the same degree of efficacy as oral NSAIDs without the systemic safety concerns. Oral NSAIDs maintain a central role in step2 Advanced management of persistent symptoms. However, oral NSAIDs are highly heterogeneous in terms of gastrointestinal and cardiovascular safety profile, and patient stratification with careful treatment selection is advocated to maximize the risk: benefit ratio. Intra-articular hyaluronic acid as a next step provides sustained clinical benefit with effects lasting up to 6 months after a short-course of weekly injections. As a last step before surgery, thes low titration of sustained-release tramadol, aweak opioid, affords sustained analgesia with improved tolerability. [less ▲]

Detailed reference viewed: 23 (12 ULg)
Full Text
Peer Reviewed
See detailCompte rendu, La mise en scène des produits et des marques. Représentations,significations, publics
Duchesne, Caroline ULg

in Questions de Communication (2016), 28

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps ... [more ▼]

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps, l’évolution stratégique de la mise en scène des marques, la place symbolique occupée par celles-ci dans l’espace social et l’interpénétration grandissante des registres commerciaux et culturels présidant à leur positionnement stratégique. [less ▲]

Detailed reference viewed: 41 (0 ULg)
Full Text
See detailEdouard Poty: a bio- and bibliography
Denayer, Julien ULg; Aretz, Markus ULg; Barchy, Laurent et al

in Geologica Belgica (2016), 19(1-2), 3-6

Detailed reference viewed: 16 (0 ULg)
Full Text
Peer Reviewed
See detailEfficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Fafin, Coraline et al

in Journal of Nephrology (2016), 29(1), 99-103

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]

Detailed reference viewed: 29 (11 ULg)
Full Text
Peer Reviewed
See detailCombined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et al

in Ann Rheum Dis (2016), 75(1), 37-44

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]

Detailed reference viewed: 11 (0 ULg)
Full Text
Peer Reviewed
See detailNewt life after fish introduction: extirpation of paedomorphosis in a mountain fish lake and newt use of satellite pools
Denoël, Mathieu ULg; Scime, Patrick; Zambelli, Nicola

in Current Zoology (2016), 62(1), 61-69

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context ... [more ▼]

Fish introduction is one of the main causes of amphibian decline worldwide. It affects particularly rare aquatic phenotypes such as paedomorphs, which retain gills during the adult stage. In this context, we determined whether small wetlands, such as pools surrounding fished and fishless lakes, could sustain paedomorphic and metamorphic newts. To this end, we surveyed lakes known historically to sustain Alpine newts (Ichthyosaura alpestris) as well as 35 nearby pools. On the basis of the published records, the only known population exhibiting paedomorphosis in the Swiss Alps was found to be extirpated by salmonid introductions. However, the metamorphs persisted in peripheral pools, paedomorphosis was discovered at a new locality, and overwintering larvae were still present in one of the lakes. These results show the importance of conserving varied aquatic habitats such as pools in mountainous environments where the main resources can become unsuitable for amphibians because of fish introductions. Pools may also function as reservoirs in maintaining newt populations until programs to remove fish from lakes can be carried out. It is not known if paedomorphs could reappear after fish removal. However, the combined resilience of amphibians after fish removal and the genetic basis for paedomorphosis highlighted in other taxa by previous studies suggest that there is the potential to maintain this intraspecific case of diversity even after its disappearance. [less ▲]

Detailed reference viewed: 197 (27 ULg)