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See detailPrognostic value of (18)F-FDG PET/CT in liver transplantation for hepatocarcinoma.
Detry, Olivier ULg; Govaerts, Laurence; De Roover, Arnaud ULg et al

in World journal of gastroenterology : WJG (2015), 21(10), 3049-54

AIM: To evaluate the prognostic value of pretreatment FDG positron emission tomography computed tomography (PET-CT) in patients with hepatocarcinoma treated by liver transplantation (LT). METHODS: The ... [more ▼]

AIM: To evaluate the prognostic value of pretreatment FDG positron emission tomography computed tomography (PET-CT) in patients with hepatocarcinoma treated by liver transplantation (LT). METHODS: The authors retrospectively analyzed the data of 27 patients (mean age 58 +/- 9 years) who underwent FDG PET-CT before LT for hepatocarcinoma. Mean follow-up was 26 +/- 18 mo. The FDG PET/CT was performed according to a standard clinical protocol: 4 MBqFDG/kg body weight, uptake 60 min, low-dose non-enhanced CT. The authors measured the SUVmax and SUVmean of the tumor and the normal liver. The tumor/liver activity ratios (RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors: MILAN, CLIP, OKUDA, TNM stage, alphafoetoprotein level, portal thrombosis, size of the largest nodule, tumor differentiation, microvascular invasion, underlying cirrhosis and liver function. RESULTS: Overall and recurrence free survivals were 80.7% and 67.4% at 3 years, and 70.6% and 67.4% at 5 years, respectively. According to a multivariate Cox model, only FDG PET/CT RSUVmax predicted recurrence free survival. Even though the MILAN criteria alone were not predictive, it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax < 1.15 relapsed. CONCLUSION: FDG PET/CT with an RSUVmax cut-off value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective series. Further prospective studies should test whether this metabolic index should be systematically included in the preoperative assessment. [less ▲]

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See detailArtificial Intelligence in Video Games: Towards a Unified Framework
Safadi, Firas ULg; Fonteneau, Raphaël ULg; Ernst, Damien ULg

in International Journal of Computer Games Technology (2015), 2015

With modern video games frequently featuring sophisticated and realistic environments, the need for smart and comprehensive agents that understand the various aspects of complex environments is pressing ... [more ▼]

With modern video games frequently featuring sophisticated and realistic environments, the need for smart and comprehensive agents that understand the various aspects of complex environments is pressing. Since video game AI is often specifically designed for each game, video game AI tools currently focus on allowing video game developers to quickly and efficiently create specific AI. One issue with this approach is that it does not efficiently exploit the numerous similarities that exist between video games not only of the same genre, but of different genres too, resulting in a difficulty to handle the many aspects of a complex environment independently for each video game. Inspired by the human ability to detect analogies between games and apply similar behavior on a conceptual level, this paper suggests an approach based on the use of a unified conceptual framework to enable the development of conceptual AI which relies on conceptual views and actions to define basic yet reasonable and robust behavior. The approach is illustrated using two video games, Raven and StarCraft: Brood War. [less ▲]

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See detailMutant p53 promotes tumor cell malignancy by both positive and negative regulation of TGF-β pathway
Lei Ji; Jinjin Xu; Jian Liu et al

in Journal of Biological Chemistry (2015)

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays ... [more ▼]

Specific p53 mutations abrogate the tumor suppressive functions by gaining new abilities to promote tumorigenesis. Inactivation of p53 is known to distort the TGF-β signaling, which paradoxically displays both tumor-suppressive and pro-oncogenic function. The molecular mechanisms how mutant p53 simultaneously antagonizes tumor-suppressive and synergizes tumor-promoting function of TGF-β pathway remain elusive. Here we demonstrate that mutant p53 differentially regulates subsets of TGF-β target genes, by an enhanced binding to the MH2 domain in Smad3 upon the integration of ERK signaling, therefore disrupting the Smad3/Smad4 complex formation. Silencing Smad2, inhibition of ERK or introducing a phosphorylation defective mutation at Ser392 in p53 abrogates the R175H mutant p53 dependent regulation of these TGF- β target genes. Our study provide a mechanism to reconcile the seemingly contradictory observations that mutant p53 can both attenuate and cooperate with the TGF-β pathway to promote cancer cell malignancy in a same cell type. [less ▲]

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See detailPhase Transformations and Crack Initiation in a High-Chromium Cast Steel Under Hot Compression Tests
Tchuindjang, Jérôme Tchoufack ULg; Neira Torres, Ingrid; Fores, Paulo et al

in Journal of Materials Engineering and Performance (2015), 24(5), 2025-2041

The mechanical behavior of the fully austenitic matrix of high-chromium cast steel (HCCS) alloy is determined by external compression stress applied at 300 and 700 C. The microstructure is roughly ... [more ▼]

The mechanical behavior of the fully austenitic matrix of high-chromium cast steel (HCCS) alloy is determined by external compression stress applied at 300 and 700 C. The microstructure is roughly characterized toward both optical and scanning electron microscopy analyses. Dilatometry is used during heating from room temperature up to austenitization to study the solid-state phase transformations, precipitation, and dissolution reactions. Two various strengthening phenomena (precipitation hardening and stress-induced bainite transformation) and one softening mechanism (dynamic recovery) are highlighted from compression tests. The influence of the temperature and the carbide type on the mechanical behavior of the HCCS material is also enhanced. Cracks observed on grain boundary primary carbides allow establishing a rough damage model. The crack initiation within the HCCS alloy is strongly dependent on the temperature, the externally applied stress, and the matrix strength and composition. [less ▲]

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See detailKLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Ali, Amjad ULg; Zhang P; Liangfang Y et al

in cell death and disease (2015)

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important ... [more ▼]

Inhibition of tumor suppressive signaling is linked to cancer progression, metastasis and epithelial-mesenchymal transition (EMT). Transforming growth factor-β1 (TGF-β)/Smad signaling plays an important role in tumor suppression. Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and EMT. However, underlying mechanisms leading to tumor suppressive and anti-metastatic function of KLF17 still remains unknown. Here, we show that KLF17 plays an integral role in potentiating TGF-β/Smad signaling via Smad3-dependent pathway to suppress tumor progression. Intriguingly, TGF-β/Smad3 signaling induces KLF17 expression, generating a positive feedback loop. TGF-β/Smad3-KLF17 loop is critical for anti-metastasis and tumor inhibition in cancer cells. Mechanistically, silencing KLF17 reduced Smad3-DNA complex formation on Smad binding element (SBE) and affects the expression of TGF-β/Smad target genes. Moreover, KLF17 alters Smad3 binding pattern on chromatin. KLF17 regulates TGF-β target genes that are Smad3-dependent. Smad3 and KLF17 physically interact with each other via KLF17 responsive elements/SBE region. Intriguingly, TGF-β stimulates the recruitment of KLF17 on chromatin to subsets of metastasis-associated genes. Functionally, depletion of KLF17 enhanced tumorigenic features in cancer cells. KLF17 is critical for full cytostatic function of TGF-β/Smad signaling. Clinically, KLF17 expression significantly decreases during advance HCC. KLF17 shows positive correlation with Smad3 levels in cancer samples. Our data shows that enhance KLF17 activity has important therapeutic implications for targeted-therapies aimed at TGF-β/Smad3 pathway. These findings define novel mechanism by which TGF-β/Smad-KLF17 pathway mutually affect each other during cancer metastasis, provide a new model of regulation of TGF-β/Smad signaling by KLF17 and defines new insights into anti-metastatic function of KLF17. [less ▲]

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See detailThe Role of Government in Path- Dependent Development of SME Sector in Ukraine
Shutyak, Yuliya; Van Caillie, Didier ULg

in Journal of East-West Business (2015), 21(1), 67-90

This article studies evolution of governmental support for SME development from the times of Perestroika until 2013. Guided by institutional theory, the article revises SME development in Ukraine and ... [more ▼]

This article studies evolution of governmental support for SME development from the times of Perestroika until 2013. Guided by institutional theory, the article revises SME development in Ukraine and explains government actions through the prism of path dependence. The analysis is conducted within a matrix logic resuming the data by several periods of time corresponding to changes in the Ukrainian government and being juxtaposed to the main stages of the path dependence analytical framework. The study reveals main trends in governmental support for small business and main challenges remaining nowadays. [less ▲]

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See detailElastic and inelastic transmission in guided atom lasers: A truncated Wigner approach
Dujardin, Julien ULg; Argüelles, Arturo; Schlagheck, Peter ULg

in Physical Review A (2015), 91

We study the transport properties of a Bose-Einstein condensate formed by an ultracold gas of bosonic atoms that is coupled from a magnetic trap into a one-dimensional waveguide. Our theoretical approach ... [more ▼]

We study the transport properties of a Bose-Einstein condensate formed by an ultracold gas of bosonic atoms that is coupled from a magnetic trap into a one-dimensional waveguide. Our theoretical approach to tackling this problem is based on the truncated Wigner method for which we assume the system to consist of two semi-infinite noninteracting leads and a finite interacting scattering region with two constrictions modeling an atomic quantum dot. The transmission is computed in the steady-state regime and we find a good agreement between truncated Wigner and matrix-product state calculations. We also identify clear signatures of inelastic resonant scattering by analyzing the distribution of energy in the transmitted atomic-matter wave beam. [less ▲]

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See detailBaryon resonances in large Nc QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Reviews of Modern Physics (2015), 87

We review the current status and present open challenges of large $N_c$ QCD baryon spectroscopy. After introducing the $1/N_c$ expansion method we first shortly revisit the latest achievements for the ... [more ▼]

We review the current status and present open challenges of large $N_c$ QCD baryon spectroscopy. After introducing the $1/N_c$ expansion method we first shortly revisit the latest achievements for the ground state properties. Next we discuss the applicability of this method to excited states, presenting two different approaches with their advantages and disadvantages. Selected results for the spectrum and strong and electromagnetic decays are described. We also present further developments for the applicability of the method to excited states, based on the qualitative compatibility between the quark excitation picture and the meson-nucleon scattering picture. We show that a quantitative comparison between results obtained from the mass formula of the $1/N_c$ expansion method and quark models brings convincing support to quark models and shortly discuss the implications of different large $N_c$ limits. We stress that the SU(6) spin-flavor structure of large $N_c$ baryon allows a convenient classification of highly excited resonances into SU(3) multiplets and predicts mass ranges for the missing partners. [less ▲]

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See detailMicrobiological quality of surface water treated with Moringa oleifera seeds or cakes during the storage : case study of water reservoirs of Loumbila, Ziga and Ouaga 3 Dams in Burkina Faso.
Kabore, Aminata; Savadogo, Boubacar; Otoidobiga, Harmonie C. et al

in Journal of Water Resource and Protection (2015), 7

Water purification with Moringa oleifera seeds has received a lot of attention because it reduces water turbidity and pathogenic microorganisms. However, it is important to define the optimum conditions ... [more ▼]

Water purification with Moringa oleifera seeds has received a lot of attention because it reduces water turbidity and pathogenic microorganisms. However, it is important to define the optimum conditions of storage to preserve the treated water quality. The study aims to investigate microbial quality of water treated with Moringa oleifera seeds or cake coagulants inrelation to the storage temperature and shelf life in order to define the optimum conditions of storage. A total of 45 water samples from 3 water reservoirs of Loumbila, Ziga and Ouaga 3 dams were collected in sterile glass bottles and treated in triplicate with Moringa oleifera seeds or defatted cakes coagulants. Treated water samples obtained at optimum conditions were stored at room temperature (25°C - 30°C) and at 4°C. Fecal bacteria pollution indicators (Escherichia coli, fecal coliforms and fecal streptococcus) and parasites were monitored every 24 hours during three (3) days abased on laboratory standard methods. Data were analyzed using the Student's t-test and XLSTAT 7.5.2 statiscal software. From the results obtained, bacterial indicators increased significantly with storage temperature (p < 0.0001) and shelf life (p < 0.0001). However, for all water samples bacterial growth was more important in samples treated with Moringa oleifera cakes than seeds (p < 0.0001). For water samples treated with Moringa oleifera seeds and stored at room temperature, bacterial increase after 72 hours was 57 - 80, 42 - 50 and 22 - 47 CFU/100 ml for fecal coliforms, E. coli and fecal streptococcus, respectively. With Moringa oleifera cake's treatment, the increase was 63 - 104, 57 - 82 and 28 - 52 for the same indicators, respectively. Bacterial growth was also more important at room temperature than at 4°C. Thus, microbiological quality of water treated with Moringa oleifera seeds was better than cakes whatever storage temperature and shelf life. Overall, water treated with Moringa oleifera seeds should be stored at low temperature and consumed within 24 hours. [less ▲]

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See detailSystematic classification of two-loop realizations of the Weinberg operator
Aristizabal Sierra, Diego ULg; Hirsch, Martin; Degée, Audrey ULg et al

in Journal of High Energy Physics [=JHEP] (2015), 2015(03),

We systematically analyze the d=5 Weinberg operator at 2-loop order. Using a diagrammatic approach, we identify two different interesting categories of neutrino mass models: (i) Genuine 2- loop models for ... [more ▼]

We systematically analyze the d=5 Weinberg operator at 2-loop order. Using a diagrammatic approach, we identify two different interesting categories of neutrino mass models: (i) Genuine 2- loop models for which both, tree-level and 1-loop contributions, are guaranteed to be absent. And (ii) finite 2-loop diagrams, which correspond to the 1-loop generation of some particular vertex appearing in a given 1-loop neutrino mass model, thus being effectively 2-loop. From the large list of all possible 2-loop diagrams, the vast majority are infinite corrections to lower order neutrino mass models and only a moderately small number of diagrams fall into these two interesting classes. Moreover, all diagrams in class (i) are just variations of three basic diagrams, with examples discussed in the literature before. Similarly, we also show that class (ii) diagrams consists of only variations of these three plus two more basic diagrams. Finally, we show how our results can be consistently and readily used in order to construct two-loop neutrino mass models. [less ▲]

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See detailPre-employement examination for low back risk in workers exposesd to manual handling of loads : French guidelines
PETIT, Audrey; ROUSSEAU, Sandrine; HUEZ, Jean-François et al

in International Archives of Occupational and Environmental Health (2015)

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See detailHow do harpacticoid copepods colonize detrital seagrass leaves?
Mascart, Thibaud ULg; Agusto, Laura; Lepoint, Gilles ULg et al

in Marine Biology (2015), 162(5), 929-943

An experiment was carried out investigating the colonization ability and specific pattern of copepods towards a provisional benthic habitat. Since copepods are known to disperse passively and actively ... [more ▼]

An experiment was carried out investigating the colonization ability and specific pattern of copepods towards a provisional benthic habitat. Since copepods are known to disperse passively and actively, the experiment aimed to investigate the pool of colonizers of macrophytodetritus and the species-specific active colonization pathways. The experiment was performed in a Mediterranean seagrass Posidonia oceanica meadow on defaunated macrophytodetritus accumulations (mainly dead seagrass leaves) for two time intervals (24 h and 96 h). Active colonization by copepods, independently of their adjacent potential source pool habitat (bare sandy sediments, P. oceanica canopy, water column and macrophytodetritus) occurred within 24 h. Natural densities (as in the control treatments) were only reached by active colonization through the water column. Both neither diversities nor species composition of natural macrophytodetritus were ever reached by one single migratory pathway, therefore only a combination of interstitial migration and water column migration can explain the species occurrence under natural condition. Moreover, every potential adjacent source pool habitat, contributed species to the newly colonized macrophytodetritus. However, the main colonizers were mostly species with good swimming capabilities. The diverse pool of species present in the newly colonized macrophytodetritus underlines the complex communities and dispersion capabilities of copepods. Hence, macrophytodetritus possesses the potential ability to be a colonizer source pool for every adjacent habitat and thus behaves as a copepod hub for the entire seagrass ecosystem. [less ▲]

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See detailInfluence of the textural parameters of resorcinol–formaldehyde dry polymers and carbon xerogels on particle sizes upon mechanical milling
Piedboeuf, Marie-Laure ULg; Léonard, Alexandre ULg; Traina, Karl et al

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2015), 471

Porous carbons find various applications in catalysis, electrochemical storage or sorption. Prior to use, their particle sizes need however to be controlled according to the targeted application. In this ... [more ▼]

Porous carbons find various applications in catalysis, electrochemical storage or sorption. Prior to use, their particle sizes need however to be controlled according to the targeted application. In this study, the grinding behavior of materials prepared from aqueous resorcinol–formaldehyde mixtures and displaying different pore textures was studied in detail. Both dry polymer gels and pyrolyzed carbon xerogels were compared in terms of particle size distributions after planetary ball-milling. The results show that the pore texture and the qualitative hardness of the materials have a strong influence on the grinding behavior, especially if carbon xerogels pyrolyzed before grinding are considered. On the other hand, it appears that the milling of polymer gels, followed by a pyrolysis step, is the most efficient way to obtain homogeneous particle size distributions, for all of the investigated mesopore textures. In this case, carbon particles displaying a narrow grain size distribution centered on a mode value near 10 μm are successfully obtained after similar grinding durations, with retention of the mesopore texture of the starting materials. This work also demonstrates the possibility of using mercury intrusion porosimetry as an interesting tool to assess simultaneously the mesopore dimensions and the particle sizes of porous powders. [less ▲]

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See detailLes droits fondamentaux, une substance malléable pour le juge? Propos sur la "dématérialisation" des droits fondamentaux
Rosoux, Géraldine ULg

in Justice-en-ligne (2015)

Ce texte contient un résumé de la thèse de doctorat de l'auteur; il est disponible en ligne: http://www.justice-enligne.be/article706.html.

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See detailAssessing the operation rules of a reservoir system based on a detailed modelling chain
Bruwier, Martin ULg; Erpicum, Sébastien ULg; Pirotton, Michel ULg et al

in Natural Hazards & Earth System Sciences (2015), 15

The current operation rules of two muti-purpose reservoirs are analysed based on an integrated model including a hydrological model, a hydraulic model, a model of the reservoir system and a flood damage ... [more ▼]

The current operation rules of two muti-purpose reservoirs are analysed based on an integrated model including a hydrological model, a hydraulic model, a model of the reservoir system and a flood damage model. Five performance indicators have been defined, reflecting the ability to provide drinking water, to control floods, to produce hydropower and to reduce low-flow conditions. Then, impacts of two climate change scenarios are assessed and enhanced operation rules are proposed for mitigation. [less ▲]

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See detailRotation, spectral variability, magnetic geometry and magnetosphere of the Of?p star CPD -28° 2561
Wade, G. A.; Barbá, R. H.; Grunhut, J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 447

We report magnetic and spectroscopic observations and modelling of the Of?p star CPD -28° 2561. Using more than 75 new spectra, we have measured the equivalent width variations and examined the dynamic ... [more ▼]

We report magnetic and spectroscopic observations and modelling of the Of?p star CPD -28° 2561. Using more than 75 new spectra, we have measured the equivalent width variations and examined the dynamic spectra of photospheric and wind-sensitive spectral lines. A period search results in an unambiguous 73.41 d variability period. High-resolution spectropolarimetric data analysed using least-squares deconvolution yield a Zeeman signature detected in the mean Stokes V profile corresponding to phase 0.5 of the spectral ephemeris. Interpreting the 73.41 d period as the stellar rotational period, we have phased the equivalent widths and inferred longitudinal field measurements. The phased magnetic data exhibit a weak sinusoidal variation, with maximum of about 565 G at phase 0.5, and a minimum of about -335 G at phase 0.0, with extrema approximately in phase with the (double-wave) Hα equivalent width variation. Modelling of the Hα equivalent width variation assuming a quasi-3D magnetospheric model produces a unique solution for the ambiguous couplet of inclination and magnetic obliquity angles: (i, β) or (β, i) = (35°, 90°). Adopting either geometry, the longitudinal field variation yields a dipole polar intensity B[SUB]d[/SUB] = 2.6 ± 0.9 kG, consistent with that obtained from direct modelling of the Stokes V profiles. We derive a wind magnetic confinement parameter η[SUB]*[/SUB] ≃ 100, leading to an Alfvén radius R[SUB]A[/SUB] ≃ 3-5R[SUB]*[/SUB], and a Kepler radius R[SUB]K[/SUB] ≃ 20R[SUB]*[/SUB]. This supports a physical scenario in which the Hα emission and other line variability have their origin in an oblique, corotating `dynamical magnetosphere' structure resulting from a magnetically channelled wind. Nevertheless, the details of the formation of spectral lines and their variability within this framework remain generally poorly understood. [less ▲]

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See detailWISE J072003.20-084651.2: an Old and Active M9.5 + T5 Spectral Binary 6 pc from the Sun
Burgasser, Adam J.; Gillon, Michaël ULg; Melis, Carl et al

in Astronomical Journal (The) (2015), 149

We report observations of the recently discovered, nearby late-M dwarf WISE J072003.20-084651.2. New astrometric measurements obtained with the TRAPPIST telescope improve the distance measurement to 6.0 ± ... [more ▼]

We report observations of the recently discovered, nearby late-M dwarf WISE J072003.20-084651.2. New astrometric measurements obtained with the TRAPPIST telescope improve the distance measurement to 6.0 ± 1.0 pc and confirm the low tangential velocity (3.5 ± 0.6 km s[SUP]-1[/SUP]) reported by Scholz. Low-resolution optical spectroscopy indicates a spectral type of M9.5 and prominent Hα emission (< {{log }[SUB]10[/SUB]}{{L}[SUB]Hα [/SUB]}/{{L}[SUB]bol[/SUB]}> = -4.68 ± 0.06), but no evidence of subsolar metallicity or Li i absorption. Near-infrared spectroscopy reveals subtle peculiarities that can be explained by the presence of a T5 binary companion, and high-resolution laser guide star adaptive optics imaging reveals a faint (ΔH = 4.1) candidate source 0\buildrel{\prime\prime}\over{.} 14 (0.8 AU) from the primary. With high-resolution optical and near-infrared spectroscopy, we measure a stable radial velocity of +83.8 ± 0.3 km s[SUP]-1[/SUP], indicative of old disk kinematics and consistent with the angular separation of the possible companion. We measure a projected rotational velocity of v sin i = 8.0 ± 0.5 km s[SUP]-1[/SUP] and find evidence of low-level variabilty (˜1.5%) in a 13 day TRAPPIST light curve, but cannot robustly constrain the rotational period. We also observe episodic changes in brightness (1%-2%) and occasional flare bursts (4%-8%) with a 0.8% duty cycle, and order-of-magnitude variations in Hα line strength. Combined, these observations reveal WISE J0720-0846 to be an old, very low-mass binary whose components straddle the hydrogen burning minimum mass, and whose primary is a relatively rapid rotator and magnetically active. It is one of only two known binaries among late M dwarfs within 10 pc of the Sun, both of which harbor a mid T-type brown dwarf companion. We show that while this specific configuration is rare (≲1.6% probability), roughly 25% of binary companions to late-type M dwarfs in the local population are likely low-temperature T or Y brown dwarfs. Some of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. [less ▲]

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See detailThe small binary asteroid (939) Isberga
Carry, B.; Matter, A.; Scheirich, P. et al

in Icarus (2015), 248

In understanding the composition and internal structure of asteroids, their density is perhaps the most diagnostic quantity. We aim here at characterizing the surface composition, mutual orbit, size, mass ... [more ▼]

In understanding the composition and internal structure of asteroids, their density is perhaps the most diagnostic quantity. We aim here at characterizing the surface composition, mutual orbit, size, mass, and density of the small main-belt binary asteroid (939) Isberga. For that, we conduct a suite of multi-technique observations, including optical lightcurves over many epochs, near-infrared spectroscopy, and interferometry in the thermal infrared. We develop a simple geometric model of binary systems to analyze the interferometric data in combination with the results of the lightcurve modeling. From spectroscopy, we classify Ibserga as a Sq-type asteroid, consistent with the albedo of 0.14<SUB>-0.06</SUB><SUP>+0.09</SUP> (all uncertainties are reported as 3-σ range) we determine (average albedo of S-types is 0.197 ± 0.153, see Pravec et al. (Pravec et al. [2012]. Icarus 221, 365-387). Lightcurve analysis reveals that the mutual orbit has a period of 26.6304 ± 0.0001 h, is close to circular (eccentricity lower than 0.1), and has pole coordinates within 7° of (225°, +86°) in Ecliptic J2000, implying a low obliquity of 1.5<SUB>-1.5</SUB><SUP>+6.0</SUP> deg . The combined analysis of lightcurves and interferometric data allows us to determine the dimension of the system and we find volume-equivalent diameters of 12.4<SUB>-1.2</SUB><SUP>+2.5</SUP> km and 3.6<SUB>-0.3</SUB><SUP>+0.7</SUP> km for Isberga and its satellite, circling each other on a 33 km wide orbit. Their density is assumed equal and found to be 2.91<SUB>-2.01</SUB><SUP>+1.72</SUP> gcm<SUP>-3</SUP> , lower than that of the associated ordinary chondrite meteorites, suggesting the presence of some macroporosity, but typical of S-types of the same size range (Carry [2012]. Planet. Space Sci. 73, 98-118). The present study is the first direct measurement of the size of a small main-belt binary. Although the interferometric observations of Isberga are at the edge of MIDI capabilities, the method described here is applicable to others suites of instruments (e.g., LBT, ALMA). [less ▲]

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See detailSpectroscopic variability of two Oe stars
Rauw, Grégor ULg; Morel, Thierry ULg; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2015), 575

Context. The two Oe stars HD 45 314 and HD 60 848 have recently been found to exhibit very different X-ray properties: whilst HD 60 848 has an X-ray spectrum and the emission level typical of most OB ... [more ▼]

Context. The two Oe stars HD 45 314 and HD 60 848 have recently been found to exhibit very different X-ray properties: whilst HD 60 848 has an X-ray spectrum and the emission level typical of most OB stars, HD 45 314 features a much harder and brighter X-ray emission, making it a so-called γ Cas analogue. Aims: Monitoring the optical spectra could provide hints towards the origin of these very different behaviours. Methods: We analyse a large set of spectroscopic observations of HD 45 314 and HD 60 848, extending over 20 years. We further attempt to fit the Hα line profiles of both stars with a simple model of emission line formation in a Keplerian disk. Results: Strong variations in the strengths of the Hα, Hβ, and He i λ 5876 emission lines are observed for both stars. In the case of HD 60 848, we find a time lag between the variations in the equivalent widths of these lines, which is currently not understood. The emission lines are double peaked with nearly identical strengths of the violet and red peaks. The Hα profile of this star can be successfully reproduced by our model of a disk seen under an inclination of 30°. In the case of HD 45 314, the emission lines are highly asymmetric and display strong line profile variations. We find a major change in behaviour between the 2002 outburst and the one observed in 2013. This concerns both the relationship between the equivalent widths of the various lines and their morphologies at maximum strength (double-peaked in 2002 versus single-peaked in 2013). Our simple disk model fails to reproduce the observed Hα line profiles of HD 45 314. Conclusions: Our results further support the interpretation that Oe stars do have decretion disks similar to those of Be stars. Whilst the emission lines of HD 60 848 are explained well by a disk with a Keplerian velocity field, the disk of HD 45 314 seems to have a significantly more complex velocity field that could be another signature of the phenomenon that produces its peculiar X-ray emission. [less ▲]

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See detailHow well can cold dark matter substructures account for the observed radio flux-ratio anomalies
Xu, Dandan; Sluse, Dominique ULg; Gao, Liang et al

in Monthly Notices of the Royal Astronomical Society (2015), 447

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM ... [more ▼]

Discrepancies between the observed and model-predicted radio flux ratios are seen in a number of quadruply-lensed quasars. The most favoured interpretation of these anomalies is that cold dark matter (CDM) substructures present in lensing galaxies perturb the lens potentials and alter image magnifications and thus flux ratios. So far no consensus has emerged regarding whether or not the predicted CDM substructure abundance fully accounts for the lensing flux anomaly observations. Accurate modelling relies on a realistic lens sample in terms of both the lens environment and internal structures and substructures. In this paper, we construct samples of generalized and specific lens potentials, to which we add (rescaled) subhalo populations from the galaxy-scale Aquarius and the cluster-scale Phoenix simulation suites. We further investigate the lensing effects from subhaloes of masses several orders of magnitude below the simulation resolution limit. The resulting flux-ratio distributions are compared to the currently best available sample of radio lenses. The observed anomalies in B0128+437, B0712+472 and B1555+375 are more likely to be caused by propagation effects or oversimplified/improper lens modelling, signs of which are already seen in the data. Among the quadruple systems that have closely located image triplets/pairs, the anomalous flux ratios of MG0414+0534 can be reproduced by adding CDM subhaloes to its macroscopic lens potential, with a probability of 5-20 per cent; for B0712+472, B1422+231, B1555+375 and B2045+265, these probabilities are only of a few per cent. We hence find that CDM substructures are unlikely to be the whole reason for radio flux anomalies. We discuss other possible effects that might also be at work. [less ▲]

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See detailSearch for magnetic fields in particle-accelerating colliding-wind binaries
Neiner, C.; Grunhut, J.; Leroy, B. et al

in Astronomy and Astrophysics (2015), 575

Some colliding-wind massive binaries, called particle-accelerating colliding-wind binaries (PACWB), exhibit synchrotron radio emission, which is assumed to be generated by a stellar magnetic field ... [more ▼]

Some colliding-wind massive binaries, called particle-accelerating colliding-wind binaries (PACWB), exhibit synchrotron radio emission, which is assumed to be generated by a stellar magnetic field. However, no measurement of magnetic fields in these stars has ever been performed. We aim at quantifying the possible stellar magnetic fields present in PACWB to provide constraints for models. We gathered 21 high-resolution spectropolarimetric observations of 9 PACWB available in the ESPaDOnS, Narval and HarpsPol archives. We analysed these observations with the least squares deconvolution method. We separated the binary spectral components when possible. No magnetic signature is detected in any of the 9 PACWB stars and all longitudinal field measurements are compatible with 0 G. We derived the upper field strength of a possible field that could have remained hidden in the noise of the data. While the data are not very constraining for some stars, for several stars we could derive an upper limit of the polar field strength of the order of 200 G. We can therefore exclude the presence of strong or moderate stellar magnetic fields in PACWB, typical of the ones present in magnetic massive stars. Weak magnetic fields could however be present in these objects. These observational results provide the first quantitative constraints for future models of PACWB. [less ▲]

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See detailModification of standard ISHAGE methodology for CD34+ cells count on thawed Cord Blood Units: results from a multi-center Eurocord/Netcord study
Saccardi, RICCARDO; Azqueta, C; Ballerini, C et al

in Bone Marrow Transplantation (2015), 50

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See detailWASP-20b and WASP-28b: a hot Saturn and a hot Jupiter in near-aligned orbits around solar-type stars
Anderson, D. R.; Collier Cameron, A.; Hellier, C. et al

in Astronomy and Astrophysics (2015), 575

We report the discovery of the planets WASP-20b and WASP-28b along with measurements of their sky-projected orbital obliquities. WASP-20b is an inflated, Saturn-mass planet (0.31 M[SUB]Jup[/SUB]; 1.46 R ... [more ▼]

We report the discovery of the planets WASP-20b and WASP-28b along with measurements of their sky-projected orbital obliquities. WASP-20b is an inflated, Saturn-mass planet (0.31 M[SUB]Jup[/SUB]; 1.46 R[SUB]Jup[/SUB]) in a 4.9-day, near-aligned (λ = 12.7 ± 4.2°) orbit around CD-24 102 (V = 10.7; F9). Due to the low density of the planet and the apparent brightness of the host star, WASP-20 is a good target for atmospheric characterisation via transmission spectroscopy. WASP-28b is an inflated, Jupiter-mass planet (0.91 M[SUB]Jup[/SUB]; 1.21 R[SUB]Jup[/SUB]) in a 3.4-day, near-aligned (λ = 8 ± 18°) orbit around a V = 12, F8 star. As intermediate-mass planets in short orbits around aged, cool stars (7[SUP]+ 2[/SUP][SUB]-1[/SUB] Gyr and 6000 ± 100 K for WASP-20; 5[SUP]+ 3[/SUP][SUB]-2[/SUB] Gyr and 6100 ± 150 K for WASP-28), their orbital alignment is consistent with the hypothesis that close-in giant planets are scattered into eccentric orbits with random alignments, which are then circularised and aligned with their stars' spins via tidal dissipation. Based on observations made with: the WASP-South (South Africa) and SuperWASP-North (La Palma) photometric survey instruments; the C2 and EulerCam cameras and the CORALIE spectrograph, all mounted on the 1.2-m Euler-Swiss telescope (La Silla); the HARPS spectrograph on the ESO 3.6-m telescope (La Silla) under programs 072.C-0488, 082.C-0608, 084.C-0185, and 085.C-0393; and LCOGT's Faulkes Telescope North (Maui) and Faulkes Telescope South (Siding Spring).Full Tables 2 and 3 are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/575/A61">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/575/A61</A> [less ▲]

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See detailThe HARPS search for southern extra-solar planets. XXXVI. Planetary systems and stellar activity of the M dwarfs GJ 3293, GJ 3341, and GJ 3543
Astudillo-Defru, N.; Bonfils, X.; Delfosse, X. et al

in Astronomy and Astrophysics (2015), 575

Context. Planetary companions of a fixed mass induce reflex motions with a larger amplitude around lower-mass stars, which adds to making M dwarfs excellent targets for extra-solar planet searches. The ... [more ▼]

Context. Planetary companions of a fixed mass induce reflex motions with a larger amplitude around lower-mass stars, which adds to making M dwarfs excellent targets for extra-solar planet searches. The most recent velocimeters with a stability of ~1 m s[SUP]-1[/SUP] can detect very low-mass planets out to the habitable zone of these stars. Low-mass small planets are abundant around M dwarfs, and most of the known potentially habitable planets orbit one of these cool stars. <BR /> Aims: Our M-dwarf radial velocity monitoring with HARPS on the ESO 3.6 m telescope at La Silla observatory makes a major contribution to this sample. <BR /> Methods: We present here dense radial velocity (RV) time series for three M dwarfs observed over ~five years: GJ 3293 (0.42 M[SUB]⊙[/SUB]), GJ 3341 (0.47 M[SUB]⊙[/SUB]), and GJ 3543 (0.45 M[SUB]⊙[/SUB]). We extracted these RVs through minimum χ[SUP]2[/SUP]-matching of each spectrum against a stack of all observed spectra for the same star that has a high signal-to-noise ratio. We then compared potential orbital signals against several stellar activity indicators to distinguish the Keplerian variations induced by planets from the spurious signals that result from rotational modulation of stellar surface inhomogeneities and from activity cycles. <BR /> Results: Two Neptune-mass planets - msin(i) = 1.4 ± 0.1 and 1.3 ± 0.1M[SUB]nept[/SUB] - orbit GJ 3293 with periods P = 30.60 ± 0.02 d and P = 123.98 ± 0.38 d, possibly together with a super-Earth - msin(i) ~ 7.9 ± 1.4 M[SUB]⊕[/SUB] - with period P = 48.14 ± 0.12d. A super-Earth - msin(i) ~ 6.1 M[SUB]⊕[/SUB] - orbits GJ 3341 with P = 14.207 ± 0.007d. The RV variations of GJ 3543, on the other hand, reflect its stellar activity rather than planetary signals. Based on observations made with the HARPS instrument on the ESO 3.6 m telescope under the program IDs 072.C-0488, 082.C-0718 and 183.C-0437 at Cerro La Silla (Chile).Tables A.1-A.3 (radial velocity data) are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424253/olm">http://www.aanda.org</A> and at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/575/A119">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/575/A119</A> [less ▲]

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See detailReflections about the optimisation of the treatment of tendinopathies with PRP
Kaux, Jean-François ULg; Bouvard, Marc; LECUT, Christelle ULg et al

in Muscles, Ligaments and Tendons Journal (2015), 5(1 (eCollection 2015 Jan-Mar)), 1-4

Background: platelet-rich plasma (PRP) infiltration represents a recent therapy for chronic tendinopathies. However, in the literature, this treatment remains controversial. Purpose: we suggest some ideas ... [more ▼]

Background: platelet-rich plasma (PRP) infiltration represents a recent therapy for chronic tendinopathies. However, in the literature, this treatment remains controversial. Purpose: we suggest some ideas for improving this treatment. Methods: these suggestions were based on a review of published studies and our clinical experience. Conclusion: optimizing the technique for PRP collection is paramount. Different risk factors must be corrected before infiltration and chronic tendinopathies must be carefully selected. Finally, post-infiltration rehabilitation remains absolutely critical. Standardization of the use of PRP remains necessary in order to optimize the results. [less ▲]

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See detailBuilding on anticipation: dystopia as empowerment
Claisse, Frédéric ULg; Delvenne, Pierre ULg

in Current Sociology (2015), 63(2),

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical ... [more ▼]

A dystopia can be defined as the depiction of a dark future building on the systematic amplification of current trends and features. It relates to a complex narrative posture that relies on the critical observation of a threatening present that would lead to an apocalyptic future “if nothing was done.” Yet, however inescapable this future may be described, the very existence of such a narrative presupposes that the political community it tries to reach is actually able to do something to thwart it. Oddly enough, a successful dystopia aims at making itself obsolete: once the world it depicts is identified as a possible (or even unavoidable) future, it seems to empower its readers again, restoring what Musil called a ‘sense of possibilities’ that eventually make alternative pathways thinkable. In our contribution, we propose to broaden the range of commonly accepted dystopists (usually fiction writers and novelists like e.g. George Orwell’s 1984) to sociologists like Ulrich Beck. Building on his Risk Society (1986), Beck’s strong diagnosis about the breakdown of First Modernity and the coming of Second Modernity contains a noticeable prophetic and evangelical overtone that aims at “reinventing politics.” We defend the notion that the dystopian posture can be used to characterize both fiction and nonfiction writers such as Orwell and Beck: a common ability, based on the same set of inextricably cognitive and normative patterns, to anticipate the future and eventually empower political communities to engage in further action. [less ▲]

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See detailVeno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model
MORIMONT, Philippe ULg; GUIOT, Julien ULg; Desaive, Thomas ULg et al

in Acta Anaesthesiologica Scandinavica (2015)

BACKGROUND: Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ... [more ▼]

BACKGROUND: Protective lung ventilation is recommended in patients with acute respiratory distress syndrome (ARDS) to minimize additional injuries to the lung. However, hypercapnic acidosis resulting from ventilation at lower tidal volume enhances pulmonary hypertension and might induce right ventricular (RV) failure. We investigated if extracorporeal veno-venous CO2 removal therapy could have beneficial effects on pulmonary circulation and RV function. METHODS: This study was performed on an experimental model of ARDS obtained in eight anaesthetized pigs connected to a volume-cycled ventilator. A micromanometer-tipped catheter was inserted into the main pulmonary artery and an admittance micromanometer-tipped catheter was inserted into the right ventricle. RV-arterial coupling was derived from RV pressure-volume loops. ARDS was obtained by repeated bronchoalveolar lavage. Protective ventilation was then achieved, and the pigs were connected to a pump-driven extracorporeal membrane oxygenator (PALP, Maquet, Germany) in order to achieve CO2 removal. RESULTS: ARDS induced severe hypercapnic acidosis. Systolic pulmonary artery pressure significantly increased from 29.6 ± 1.8 to 43.9 ± 2.0 mmHg (P < 0.001). After the PALP was started, acidosis was corrected and normocarbia was maintained despite protective ventilation. Pulmonary artery pressure significantly decreased to 31.6 ± 3.2 mmHg (P < 0.001) and RV-arterial coupling significantly improved (RV-arterial coupling index = 1.03 ± 0.33 vs. 0.55 ± 0.41, P < 0.05). CONCLUSION: Veno-venous CO2 removal therapy enabled protective ventilation while maintaining normocarbia during ARDS. CO2 removal decreased pulmonary hypertension and improved RV function. This technique may be an effective lung- and RV-protective adjunct to mechanical ventilation. [less ▲]

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See detailCharacterization of building materials from the aqueduct of Antioch-on-the-Orontes (Turkey)
Benjelloun, Yacine; de Sigoyer, Julia; Carlut, Julia et al

in Comptes Rendus Geoscience (2015)

The Roman aqueduct of Antioch-on-the-Orontes (Turkey), a city located near the junction between the active Dead Sea fault and the East Anatolian fault, has been damaged several times due to historical ... [more ▼]

The Roman aqueduct of Antioch-on-the-Orontes (Turkey), a city located near the junction between the active Dead Sea fault and the East Anatolian fault, has been damaged several times due to historical earthquakes, as mentioned in ancient texts. The traces of repairs are studied in order to identify their potential seismic origin. The deformations of the structure were characterised thanks to a LIDAR scan. Several bricks were sampled on different parts of the city’s aqueducts, on the original structure and on repaired parts. The bricks were characterized through a petrological approach. 14C and archaeomagnetism were tested on the bricks in order to constrain the age of their production. The synthesis of all the data showed a local origin for the bricks, and led to the identification of several manufacturing techniques and several types of production, thus, confirming the potentiality of this approach to date and characterise post-seismic repairs. [less ▲]

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See detailRumination time, milk yield, milking frequency of grazing dairy cows milked by a mobile automatic system during mild heat stress
Lessire, Françoise ULg; Hornick, Jean-Luc ULg; Minet, Julien ULg et al

in Advances in Animal Biosciences (2015), 6(01), 12-14

Grazing dairy cows milked by an automatic system (AS) experienced mild heat stress (HS) periods, twice during the summer. The daily temperature humidity index (THI) during these periods were higher than ... [more ▼]

Grazing dairy cows milked by an automatic system (AS) experienced mild heat stress (HS) periods, twice during the summer. The daily temperature humidity index (THI) during these periods were higher than 72. Milk production, as well as milking frequency, rumination time and milk fat to protein ratio (F/P) during these periods were compared to adjacent periods with mean THI of 61. The daily milking frequency, the total number of visits to AS and the milk production were significantly higher in HS periods (2.12 vs 1.97, 2.99 vs 2.69, and 19.7 vs 18.5 kg milk per cow, respectively). There were significant interactions between times and periods for milking frequency and number of visits, while the daily rumination time was significantly lower (339 vs 419 min) and the F/P in milk tended to be decreased (1.17 vs 1.23). These results could be explained by changes in cow behaviour during HS periods. [less ▲]

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See detailAgriculture et changement climatique. Vers la définition d'un nouvel objectif para-agricole
Habran, Maxime ULg

in Revue de la Faculté de Droit de l'Université de Liège (2015), 2015-/1

Cette contribution illustre la façon dont le législateur européen tente d’adapter la PAC à la lutte contre le changement climatique. Dans le cadre de la nouvelle réforme mise en place en janvier 2014 et ... [more ▼]

Cette contribution illustre la façon dont le législateur européen tente d’adapter la PAC à la lutte contre le changement climatique. Dans le cadre de la nouvelle réforme mise en place en janvier 2014 et reportée début 2015, l’accent est mis sur les mesures prévues pour réaliser le nouvel objectif de la politique environnementale. [less ▲]

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See detailAssessing variability of literature based methane indicator traits in a large dairy cow population
Kandel, Purna Bhadra ULg; Gengler, Nicolas ULg; Soyeurt, Hélène ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 11-19

Description du sujet. La production laitière est reconnue comme une des sources majeures d’émissions de méthane (CH4). Le recours à un programme de sélection spécifique pourrait être une bonne méthode ... [more ▼]

Description du sujet. La production laitière est reconnue comme une des sources majeures d’émissions de méthane (CH4). Le recours à un programme de sélection spécifique pourrait être une bonne méthode pour optimiser les émissions de méthane par les vaches laitières. Le développement d’un tel programme nécessiterait un nombre important d’enregistrements relatifs aux émissions de méthane. Malheureusement, aucune méthode pratique et bon marché n’existe actuellement pour créer une telle base de données. Cependant, quatre indicateurs CH4 basés sur les quantités en acides gras dans la matière grasse laitière ont été recensés dans la littérature. Objectifs. L’objectif de cette étude est d’utiliser ces indicateurs de la littérature afin d’apprécier la variabilité des émissions de méthane éructées par les vaches laitières. Méthode. Ces indicateurs utilisent les quantités en acides gras obtenues par chromatographie en phase gazeuse. Comme ce type de données n’est pas disponible pour toute la population laitière, un échantillon de 602 analyses chromatographiques a été créé dans cette étude afin de développer une équation de calibrage permettant de prédire les quantités de méthane émises à partir du spectre moyen infrarouge (MIR) du lait qui est disponible pour toutes les vaches étudiées. Ensuite, l’équation de calibrage ainsi obtenue a été appliquée sur 604 028 données spectrales enregistrées entre 2007 et 2011 auprès de 70 872 vaches au cours de leurs trois premières lactations afin de prédire les quantités de méthane émises. Les paramètres génétiques de ces nouveaux indicateurs méthane prédits par MIR ont également été estimés en utilisant un modèle animal de type jour de test avec régressions aléatoires. Résultats. Ces quantités prédites par MIR variaient selon une gamme attendue s’étalant entre 350 ± 40 et 449 ± 65 g par jour. L’émission prédite moyenne de CH4 en g par jour augmentait au début de la lactation, atteignait sa plus haute concentration au pic de lactation et ensuite diminuait jusqu’à la fin de la lactation. Les héritabilités journalières moyennes variaient entre 0,29-0,35 ; 0,26-0,40 et 0,22-0,37 pour les différents indicateurs méthane étudiés au cours des trois premières lactations. Les plus grandes différences entre les valeurs d’élevage estimées pour des taureaux ayant des filles en production émettant le plus et le moins de méthane étaient de 24,18 ; 29,33 et 27,77 kg par lactation pour les trois premières lactations. Des corrélations faiblement négatives ont été observées entre les indicateurs CH4 et la quantité de lait. À l’inverse, des corrélations positives ont été estimées entre ces mêmes indicateurs et les taux en matières grasses et en protéines. Conclusions. Cette étude montre la possibilité de prédire des indicateurs méthane issus de la littérature et utilisant les concentrations en acides gras dans la matière grasse laitière à partir de la spectrométrie MIR. De plus, cette étude suggère également à partir des paramètres génétiques obtenus l’existence d’une variabilité phénotypique et génétique des quantités de méthane éructées par les vaches laitières Holstein. [less ▲]

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See detailComment je traite ... une mucoviscidose
BENDAVID, G.; VANDERHELST, E.; LOUIS, Renaud ULg et al

in Revue Médicale de Liège (2015), 70(3), 108-114

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See detailA connection between the instability strips of ZZ Ceti and V777 Her white dwarfs
Van Grootel, Valérie ULg; Fontaine, Gilles; Brassard, Pierre et al

in Astronomy and Astrophysics (2015), 575

Aims. We aim to determine the theoretical instability strips of white dwarfs with diverse H and He content in their atmospheres, from a solar composition to a H-depleted atmosphere. Pulsators with mixed H ... [more ▼]

Aims. We aim to determine the theoretical instability strips of white dwarfs with diverse H and He content in their atmospheres, from a solar composition to a H-depleted atmosphere. Pulsators with mixed H-He atmospheres are indeed known to exist, and these are the white dwarfs in cataclysmic accreting systems of the GW Lib type. We thus also aim to determine the range of periods of excited pulsation modes, and to qualitatively compare these to the observed periods in GW Lib white dwarf pulsators. Methods. In the first full nonadiabatic stability analysis of pulsators of this kind, we applied a time-dependent convection treatment and an energy leakage argument to compute, for cooling models of white dwarfs with various masses and envelope compositions, the location of the blue and the red edges, as well as the properties of pulsation modes. Results. We find that our derived instability strips form a true continuum in the log g-Teff plane and that their individual location depends uniquely on the assumed atmospheric composition, from the solar composition models at low effective temperatures to the H-depleted models at much higher temperatures. Taking into account our previous results from the ZZ Ceti (pure H atmosphere) and V777 Her (pure He atmosphere) white dwarf pulsators, this implies that all of these instability domains are connected via the same fundamental driving mechanism. Applying our results to the case of white dwarf pulsators of the GW Lib type, we find that our theoretical instability strips can qualitatively account for all of the known cases. The computed range of periods of excited modes also compares qualitatively very well to the observed ones. Conclusions. The GW Lib pulsators are very similar in nature to ZZ Ceti and V777 Her white dwarfs. It is the diverse chemical compositions in their atmosphere and envelope that defines their specific pulsation properties. Beyond GW Lib pulsators, white dwarfs can sometimes exhibit mixed H-He atmospheres, such as in the recently found proto-He white dwarf pulsators. Our results open the way towards quantitative asteroseismology of these various kinds of white dwarfs. [less ▲]

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See detailLes procédures concurrentes en Europe: les innovations du Règlement 1215/2012
Wautelet, Patrick ULg

in Revue Droit International Privé = Tijdschrift voor Internationaal Privaatrecht (2015), 14(1), 148-163

This paper attempts to shed some light on the changes brought by the recast of the Brussels I Regulation to the regime of concurrent proceedings. In a first section, attention is devoted to the fine ... [more ▼]

This paper attempts to shed some light on the changes brought by the recast of the Brussels I Regulation to the regime of concurrent proceedings. In a first section, attention is devoted to the fine tuning of the rules aimed at intra-European concurrent proceedings. The second section focuses on the new provisions aimed at third State concurrent proceedings. [less ▲]

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See detailLes transformations de la géographie au cours des années 1970 : synthèse et témoignage final
Merenne-Schoumaker, Bernadette ULg

in Géographies. Bulletin de l'Association de Géographes Français (2015), 2015(1), 126-129

Conclusions d'un colloque organisé par Christian Grataloup à l'Université de Paris 1 le 17 mai 2014 et consacré aux mutations qui ont touché la géographie française durant les années 1970. Synthèse ... [more ▼]

Conclusions d'un colloque organisé par Christian Grataloup à l'Université de Paris 1 le 17 mai 2014 et consacré aux mutations qui ont touché la géographie française durant les années 1970. Synthèse présentée le jour-même avec un double objectif : dégager les idées majeures des dix communications de la journée et proposer quelques réflexions complémentaires. [less ▲]

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See detailImpact de l’hygiène bucco-dentaire sur le sport. Revue de la littérature
Kipgen, Laurence; Kaux, Jean-François ULg; Rompen, Eric ULg et al

in Journal de Traumatologie du Sport (2015), 32(1), 41-45

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a ... [more ▼]

Teeth are the object of multiple attentions and care but unfortunately, it is not the same case of the periodonte, their point of anchoring and essential support. What could be more commonplace than a bleeding arising during the daily brushing? Being not painful, it activates very often no concern and no request of consultation. It is nevertheless about one of the most obvious clinical signs of the periodontal diseases which affect, to varying degrees, practically 90 % of the population in France in all groups of ages and is responsible of the loss from 30 to 40 % of the teeth. For several decades, the scientific world admits a relation between the periodontal disease and certain systematic diseases, as the endocarditis, the atherosclerosis, the diabetes… And what about tendinopathies? Their appearance is often spontaneous without specific medical origin and their cure turns out long and painful. This review has for objective to highlight the relations between the oral hygiene and sportsmen. [less ▲]

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See detailDiagnosis, pathophysiology and management of chronic migraine: a proposal of the Belgian Headache Society.
Paemeleire, K; Louis, P; MAGIS, Delphine ULg et al

in Acta Neurologica Belgica (2015), 35(5), 437-442

This is a review of the pathophysiology of chronic migraine and of available therapies with a proposal for an algorithm of management.

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See detaileffects of cholecaciferol supplementation and optimized calcium intakes on vitamin D status, muscle strength and bone health: a one-year pilot randomized controlled trial in adults with severe burns
ROUSSEAU, Anne-Françoise ULg; FOIDART-DESSALLE, Marguerite ULg; LEDOUX, Didier ULg et al

in Burns : Journal of the International Society for Burn Injuries (2015), 41(2), 317-325

Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess ... [more ▼]

Objective: Burn patients are at risk of hypovitaminosis D and osteopenia or sarcopenia. Vitamin D pleiotropic effects may influence bone and muscle health. The aim of this pilot study was to assess effects of a cholecalciferol (VD3) supplementation and an optimized calcium (Ca) regimen on vitamin D (VD) status, bone and muscle health during sequelar stage of burn injury. Design: Monocentric randomized controlled trial. Methods: Fifteen adults with thermal burns dating from 2 to 5 years were randomized into two groups. For 12 months, they either received a quarterly IM injection of 200,000 IU VD3 and daily oral Ca (Group D) or placebo (Group P). VD status and bone remodeling markers were assessed every 3 months. Knee muscle strength and bone mineral density were, respectively, assessed using isokinetic dynamometry and dual X-ray absorptiometry at initiation (M0) and completion (M12) of the protocol. Results: Of all the patients, 66% presented with VD deficiency and 53% (with 3 men <40 y) were considered osteopenic at inclusion. After one year, calcidiol levels significantly increased in Group D to reach 40 (37–61) ng/ml. No significant change in bone health was observed in both groups while Group D significantly improved quadriceps strength when tested at high velocity. Conclusions: This VD3 supplementation was safe and efficient to correct hypovitaminosis D in burn adults. When combined with optimized Ca intakes, it demonstrated positive effects on muscle health but not on bone health. A high prevalence of hypovitaminosis D and osteopenia in these patients, as well as their wide range of muscle performances, seem to be worrying when considering rehabilitation and quality of life. [less ▲]

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See detailDoes the production of Belgian bioethanol fit with European requirements on GHG emissions? Case of wheat
Belboom, Sandra ULg; Bodson, Bernard ULg; Léonard, Angélique ULg

in Biomass & Bioenergy (2015), 74

This paper undertakes an environmental evaluation of bioethanol production, using wheat cultivated in Belgium. Cultivation steps are modelled using Belgian specific data. Wheat transformation in ethanol ... [more ▼]

This paper undertakes an environmental evaluation of bioethanol production, using wheat cultivated in Belgium. Cultivation steps are modelled using Belgian specific data. Wheat transformation in ethanol relies on industrial data. GHG emissions of the whole life cycle are calculated and compared with the default values given by the European Renewable Energy Directive. Belgian wheat bioethanol achieves a 5% higher GHG reduction than the one mentioned in the European directive but impact repartition is different with a higher importance of cultivation step in our case. Belgian wheat bioethanol complies with the current sustainability criteria but is also able to conform to further ones. Sensitivity analyses are performed on the importance of N fertilizers and associated emissions known as main important parameters. These analyses reveal non negligible variations and then a range of available GHG reduction when using wheat bioethanol. [less ▲]

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See detailA generalized moving-boundary algorithm to predict the heat transfer rate of counterflow heat exchangers for any phase configuration
Bell, Ian; Quoilin, Sylvain ULg; Georges, Emeline ULg et al

in Applied Thermal Engineering (2015), 79

In this work, a novel and robust solution approach is presented that can be used to predict the steady-state thermal heat transfer rate for counterflow heat exchangers with any combination of single-phase ... [more ▼]

In this work, a novel and robust solution approach is presented that can be used to predict the steady-state thermal heat transfer rate for counterflow heat exchangers with any combination of single-phase and two-phase conditions within the heat exchanger. This methodology allows for multiple internal pinching points, as well as all permutations of subcooled liquid, two-phase and superheated vapor sections for the hot and cold fluids. A residual function based on the matching of the required and available thermal conductances in each section is derived, and Brent's method is then used to drive the residual to zero. Examples are presented for the application of this methodology to a water-heated n-Propane evaporator. The computational time required to execute the model for a simple case is on the order of one millisecond when the tabular interpolation methods of CoolProp are applied. Source code for the algorithm is provided in the Python programming language as an appendix. [less ▲]

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See detailFilles et garçons : ensemble, c'est tout ?
Lafontaine, Dominique ULg

in Entrées Libres (2015), (97), 2-3

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See detailL'accoutumance à l'eau: un préalable au savoir-nager.
Mornard, Manhattan ULg; Delvaux, Anne ULg; Cloes, Marc ULg et al

in Éducation Physique et Sport (2015), (364), 16-20

Synthèse de la méthodologie et des travaux scientifiques réalisés au cours de ces dernières années par le cereki dans le domaine de l'accoutumance à l'eau.

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See detailChirurgie de l'atrésie anale du veau
Arengi, Ada; Sartelet, Arnaud ULg

in Point Vétérinaire (2015), 353

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See detailComplexity markers in morphosyntactic productions in French-speaking children with specific language impairment (SLI)
Prigent, Gaïd ULg; Parisse, Christophe; Leclercq, Anne-Lise ULg et al

in Clinical Linguistics & Phonetics (2015)

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is ... [more ▼]

The usage-based theory considers that the morphosyntactic productions of children with SLI are particularly dependent on input frequency. When producing complex syntax, the language of these children is, therefore, predicted to have a lower variability and to contain fewer infrequent morphosyntactic markers than that of younger children matched on morphosyntactic abilities. Using a spontaneous language task, the current study compared the complexity of the morphological and structural productions of 20 children with SLI and 20 language-matched peers (matched on both morphosyntactic comprehension and mean length of utterance). As expected, results showed that although basic structures were produced in the same way in both groups, several complex forms (i.e. tenses such as Imperfect, Future or Conditional and Conjunctions) were less frequent in the productions of children with SLI. Finally, we attempted to highlight complex linguistic forms that could be good clinical markers for these children. [less ▲]

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See detailConcordance between muscle mass assessed by bioelectrical impedance analysis and by dual energy X-ray absorptionmetry among elderly people: a cross-sectional study
Buckinx, Fanny ULg; Reginster, Jean-Yves ULg; Dardenne, Nadia ULg et al

in BMC Musculoskeletal Disorders (2015), 16(1), 60-67

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical ... [more ▼]

BACKGROUND: Besides magnetic resonance imaging, dual energy X-ray absorptiometry (DXA) seems the most reliable tool to evaluate body composition and is often considered as the gold standard in clinical practice. Bioelectrical impedance analysis (BIA) could provide a simpler, portative, and less expensive alternative. Because the body composition assessment by BIA is device-dependent, the aim of this study was to appraise the concordance between the specific bioelectrical impedance device InBody S10 and DXA for the body composition evaluation. METHODS: Body composition, included appendicular lean mass divided by height squared (ALM/ht2) was measured by DXA (Hologic QDR Discovery device) and by BIA (InBody S10 Biospace device). Agreement between tools was assessed by means of the Bland Altman method and reliability was determined using the IntraClass Coefficient (ICC). ICC was also computed to assess the reliability of the test-retest performed by the same operator or by two different ones. RESULTS: A total of 219 subjects were enrolled in this study (mean age: 43.7 +/- 19.1 years old, 51.6% of women). For the ALM/ht2, reliability of the test-retest of the BIA was high with an ICC of 0.89 (95%CI: 0.86-0.92) when performed by the same operator and an ICC of 0.77 (95%CI: 0.72-0.82) when performed by two different operators. Agreement between ALM/ht2 assessed by DXA and BIA was low (ICC = 0.37 (95%CI: 0.25-0.48)). Mean ALM/ht2 was 9.19 +/- 1.39 kg/m2 with BIA and 7.34 +/- 1.34 kg/m2 with DXA, (p < 0001). A formula developed using a multiple regression analysis, and taking into account muscle mass assessed by BIA, as well as sex and body mass index, explains 89% of the ALM/ht2 assessed by DXA. CONCLUSIONS: Although our results show that the measure of ALM/ht2 by BIA is reliable, the agreement between DXA and BIA is low. Indeed, BIA seems to overestimate ALM/ht2 compared to DXA and, consequently, it is important to use an adapted formula to obtain measurement of the appendicular lean mass by BIA close to that measured by DXA. [less ▲]

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See detailWhat is ... an automatic sequence?
Rowland, Eric ULg

in Notices of the American Mathematical Society (2015), 62(3), 274-276

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See detailNIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways.
Rapino, Francesca ULg; Abhari, BA; Jung, M et al

in Cell Death & Disease (2015)

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See detailLes "Acteurs des temps présents" et la convergence des luttes
Theunissen, Fanny ULg

in Politique : Revue de Débats (2015), 89

Que penser d’une alliance inédite entre syndicalistes et agriculteurs ? Comment fédérer des mouvements à la sociologie et aux méthodes d’actions parfois très distinctes ? Le décloisonnement est-il ... [more ▼]

Que penser d’une alliance inédite entre syndicalistes et agriculteurs ? Comment fédérer des mouvements à la sociologie et aux méthodes d’actions parfois très distinctes ? Le décloisonnement est-il possible, à quel prix, et sous quelle forme ? [less ▲]

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See detailGestion implantaire de l'édentement unitaire dans le secteur esthétique : une approche visant à optimiser les tissus. Partie I : aspect chirurgical
LAMBERT, France ULg

in Réalites Cliniques : Revue Européenne d'Odontologie (2015), 26(n°1),

Nous sommes tous bien conscients de la problématique liée au remodelage osseux après extraction dentaire, en particulier dans la zone esthétique. Les conséquences cliniques sont telles que le recours à ... [more ▼]

Nous sommes tous bien conscients de la problématique liée au remodelage osseux après extraction dentaire, en particulier dans la zone esthétique. Les conséquences cliniques sont telles que le recours à des techniques de régénération tissulaire est souvent nécéssaire pour la pose de l'implant et pour assurer des résultats esthétiques. Cet article vise à démontrer l'efficacité d'un protocole d'optimisation tissulaire basé sur la préservation du capital osseux et sur l'optimisation des tissus gingivaux lors d'une extraction dentaire dans la zone esthétique. L'objectif de cet article est de suggérer un processus décisionnel en matière de technique chirurgicale, reposant d'une part sur l'examen clinique initial et, d'autre part, sur une excellente compréhension du concept biologique. [less ▲]

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See detailStakeholder incentives and aid effectiveness: A case study in the health district of Kayes in Mali
Devahive, Eva; Paul, Elisabeth ULg; Samaké, Salif et al

in Journal of Development Studies (2015)

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar ... [more ▼]

This case study analyses how far donors implement aid effectiveness principles at health district level in Mali, and why. It shows that not all aid effectiveness principles are implemented at a similar degree. Most projects have limited impact on health services, but many programmes supported by donors offer positive opportunities for health system strengthening. The representations of different categories of stakeholders diverge – notably, regarding the role of different actors in service provision. A number of consistent strategic logics influence actors’ behaviour. We show that while many donors have committed at global level to respect aid effectiveness principles, implementation lags behind. [less ▲]

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See detailCompte rendu de Ulrich Herbert, Geschichte Deutschlands im 20. Jahrhundert
Brüll, Christoph ULg

in Wissenschaftlicher Literaturanzeiger [=WLA] (2015)

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See detailHigher-Moment Risk Exposures in Hedge Funds
Lambert, Marie ULg; Hübner, Georges ULg; Papageorgiou, Nicolas

in European Financial Management (2015), 21(2), 236-264

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment ... [more ▼]

This paper singles out the key roles of US equity skewness and kurtosis in the hedge fund return generating process. We propose a conditional higher-moment model with location, trading, and higher-moment factors to describe the dynamics of the equity hedge, event-driven, relative value, and fund of funds styles. If the volatility, skewness, and kurtosis implied in US options are used by fund managers as instruments to anticipate market movements, managers should adjust their market exposure in response to variations in these moments. We indeed show that higher-moment premia improve the conditional asset pricing model across all hedge fund styles. [less ▲]

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See detailCrosstalk between intracellular and extracellular signals regulating interneuron production migration and integration into the cortex
Peyre, Elise ULg; Gomes Da Silva, Carla ULg; Nguyen, Laurent ULg

in Frontiers in Cellular Neuroscience (2015)

During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the ... [more ▼]

During embryogenesis, cortical interneurons are generated by ventral progenitors located in the ganglionic eminences of the telencephalon. They travel along multiple tangential paths to populate the cortical wall. As they reach this structure they undergo intracortical dispersion to settle in their final destination. At the cellular level, migrating interneurons are highly polarized cells that extend and retract processes using dynamic remodeling of microtubule and actin cytoskeleton. Different levels of molecular regulation contribute to interneuron migration. These include: 1/ Extrinsic guidance cues distributed along migratory streams that are sensed and integrated by migrating interneurons; 2/ Intrinsic genetic programs driven by specific transcription factors that grant specification and set the timing of migration for different subtypes of interneurons; 3/ Adhesion molecules and cytoskeletal elements/regulators that transduce molecular signalings into coherent movement. These levels of molecular regulation must be properly integrated by interneurons to allow their migration in the cortex. The aim of this review is to summarize our current knowledge of the interplay between microenvironmental signals and cell autonomous programs that drive cortical interneuron porduction, tangential migration, and intergration in the developing cerebral cortex. [less ▲]

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See detailWhat is important in being cured from depression? Discordance between physicians and patients (1)
Demyttenaere, Koen; Donneau, Anne-Françoise ULg; Albert, Adelin ULg et al

in Journal of Affective Disorders (2015), 174(2015), 390-396

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See detailLaTeX, un peu, beaucoup (7. Tableaux (encore))
Dupont, Pascal ULg

in Losanges (2015), 28

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See detailEquipements remarquable: Passeport santé pour bananier
Massart, Sébastien ULg

in 15e Jour du Mois (Le) (2015), (242),

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See detailScreening of microorganisms producing polygalacturonase (PG) in microbiota of fermented cassava
Kouhounde, Sonagnon Hermann Serge ULg

in International Journal of Biochemistry and Biotechnology (2015)

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See detailAlexandre VI Borgia, le pape de la débauche
Marchandisse, Alain ULg

in Historia (2015), (Spécial 22),

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See detailNetworks of prospective thoughts: the organizational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2015)

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailRitournelles et territoires professionnels. Le cas des conseillers emploi
Orianne, Jean-François ULg

in Langage et Société (2015), 151

L’objectif de ce texte est d’utiliser le concept de ritournelle pour analyser la formation d’un groupe professionnel dans le champ des politiques d’emploi en Belgique : les conseillers emploi du FOREM ... [more ▼]

L’objectif de ce texte est d’utiliser le concept de ritournelle pour analyser la formation d’un groupe professionnel dans le champ des politiques d’emploi en Belgique : les conseillers emploi du FOREM. L’auteur commence par définir et opérationnaliser le concept, emprunté à Deleuze et Guattari, en suivant les apports des théories de la communication réflexive. Il esquisse brièvement le contexte politique et institutionnel au sein duquel le groupe professionnel apparaît. Ensuite, il analyse trois ritournelles professionnelles, trois procédés de territorialisation des identités professionnelles des conseillers emploi. Il précise, en conclusion, la complémentarité du concept de ritournelle avec celui de rhétorique professionnelle. [less ▲]

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See detailUnique recurrence patterns of cervical intraepithelial neoplasia following excision of the squamo-columnar junction.
Herfs, Michael ULg; SOMJA, Joan ULg; Howitt, Brooke E. et al

in International journal of cancer. Journal international du cancer (2015), 136

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not ... [more ▼]

Recent studies have identified a putative cell of origin for cervical intraepithelial neoplasia (CIN) and cervical cancer at the squamo-columnar junction (SCJ) and suggest that these cells may not regenerate following excision (LEEP). This study addressed the impact of SCJ excision on the temporal dynamics, histologic and viral (HPV) characteristics of recurrent CIN. One hundred thirty one consecutive patients treated by excision and attending follow-up visits were enrolled. We compared recurrent and initial CIN with attention to excision margins, timing of recurrence, CIN grade, HPV types, p16 immunophenotype, and SCJ immunophenotype. During the follow-up period (up to four years), sixteen (12.2%) recurrences were identified. Four (25%) were identified at the first follow-up visit, closely resembled the initial CIN 2/3 in grade and HPV type, and were typically SCJ marker positive [SCJ(+)], suggesting non-excised (residual) disease. Twelve (75%) manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were classified as CIN 1 and were SCJ (-). Nine of 11 SCJ (-) recurrences (82%) followed regressed spontaneously. Taken together, these results show that new lesions developing from any HPV infection are delayed and occur within the ectocervix or metaplastic epithelium. This dramatically lower risk of CIN 2/3 following successful SCJ excision suggests that removal of the SCJ could be a critical variable in reducing the risk of subsequent CIN 2/3 and cervical cancer. (c) 2014 Wiley Periodicals, Inc. [less ▲]

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See detailFires of Pianura: The Antidump Struggle in the Western Outskirt of Naples
De Biase, Marco ULg

in Capitalism, Nature, Socialism (2015), 26(1), 39-58

This ethnographic study aimed at analyzing the rebellion in Pianura, which took place between December 2007 and January 2009 when Naples' streets were covered with rubbish. It was a violent protest ... [more ▼]

This ethnographic study aimed at analyzing the rebellion in Pianura, which took place between December 2007 and January 2009 when Naples' streets were covered with rubbish. It was a violent protest involving some 40.000 people who wanted to object to the reopening of the old dump of Pianura, one of the most toxic in Europe and no longer in use. The fear for their own life, the desperation of local population, and the anger after being attacked by the police during pacific protest gave origin to a real urban guerrilla targeting the political system. This article aims to go beyond the dominant narration of the events developed by the media and the authorities, which interpreted the uprising of Pianura in terms of Nimby (Not in my back yard), and as a mere manifestation of violence that was carried out by a group of extremists. On the contrary, it will be argued that the anti-dump struggle of Pianura, in its diverse forms, was animated by a radical critique of a specific model of local and national development (Gramsci 2007; Della Porta 2006). In order to support this argument the context of Pianura and the various mobilizations set up by the local population are analysed in this article. In addition, the heterogeneous and fragmented nature of the movement is explained through Bayat’s (1997; 2000) concept of “street politics” and that of “rebel bricolage” inspired by the work of Levi-Strauss (1966). More in detail, the analysis is focused on the effects of the “waste politics” on the body of the protesters, which became an important tool of resistance and an instrument to claim fundamental rights (Fassin, Memmi 2004). Finally, this article investigates the role of some groups of ultrà (football supporters) who actively participated in the demonstrations, and their relationship with the criminalizing discourses that were constructed to discredit the struggle. [less ▲]

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See detailMulti-period stochastic optimization problems in transportation management (Ph. D. Thesis Summary)
Pironet, Thierry ULg

in 4OR : Quarterly Journal of the Belgian, French and Italian Operations Research Societies (2015), 13(1), 113-114

Ph. D Thesis summary see other reference on ORBI

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See detailL'ordre public, la révision au fond et la légalisation: bref commentaire de la circulaire du 14 janvier 2015 relative à la légalisation
Wautelet, Patrick ULg; Verhellen, Jinske

in Revue Internationale de Droit Privé = Tijdschrift voor Internationaal Privaatrecht (2015), 14(1), 142-147

Le SPF Affaires Etrangères a adopté en janvier 2015 une nouvelle circulaire relative à la légalisation. Au premier regard, l'adoption de cette nouvelle circulaire permet de tenir compte de l'entrée en ... [more ▼]

Le SPF Affaires Etrangères a adopté en janvier 2015 une nouvelle circulaire relative à la légalisation. Au premier regard, l'adoption de cette nouvelle circulaire permet de tenir compte de l'entrée en vigueur du Code consulaire. Le chapitre 7 de ce Code est en effet consacré à la légalisation et à l'examen des documents étrangers. Il indique quelle autorité est compétente pour procéder à la légalisation d'un document (art. 33) et confirme la pratique antérieure des 'remarques' pouvant être apposées sur un acte étranger lorsqu'un doute sérieux existe sur l'authenticité de l'acte ou sur l'authenticité de son contenu (art. 34). Tous ces textes font référence à l'article 30 du Code de droit international privé, disposition qui constitue le socle de base dans ce domaine. A bien y regarder la nouvelle circulaire introduit néanmoins deux innovation importantes bien que singulières. Ces deux innovations pourraient avoir comme effet d'empêcher l'utilisation d'un acte étranger en Belgique. La présente contribution s'interroge de manière critique sur ces deux innovations en questionnant tant leur pertinence que leur efficacité. [less ▲]

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See detailAn efficient flamelet-based combustion model for compressible flows
Saghafian, Amirreza; Terrapon, Vincent ULg; Pitsch, Heinz

in Combustion and Flame (2015), 162(3), 652-667

A combustion model based on a flamelet/progress variable approach for high-speed flows is introduced. In the proposed formulation, the temperature is computed from the transported total energy and ... [more ▼]

A combustion model based on a flamelet/progress variable approach for high-speed flows is introduced. In the proposed formulation, the temperature is computed from the transported total energy and tabulated species mass fractions. Only three additional scalar equations need to be solved for the combustion model. Additionally, a flamelet library is used that is computed in a pre-processing step. This approach is very efficient and allows for the use of complex chemical mechanisms. An approximation is also introduced to eliminate costly iterative steps during the temperature calculation. To better account for compressibility effects, the chemical source term of the progress variable is rescaled with the density and temperature. The compressibility corrections are analyzed in an a priori study. The model is also tested in both Reynolds-averaged Navier–Stokes (RANS) and large-eddy simulation (LES) computations of a hydrogen jet in a supersonic transverse flow. Comparison with experimental measurements shows good agreement, particularly for the LES case. It is found that the disagreement between RANS results and experimental data is mostly due to the mixing model deficiencies and the presumed probability density functions used in the RANS formulation. A sensitivity study of the proposed model shows the importance of the compressibility corrections especially for the source term of the progress variable. [less ▲]

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See detailData in support of metabolic reprogramming in transformed mouse cortical astrocytes: A proteomic study
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Hervé et al

in Data in Brief (2015), 2(0), 1-5

2D-DIGE analysis coupled with mass spectrometry is a global, without a priori, comparative proteomic approach particularly suited to identify and quantify enzymes isoforms and structural proteins, thus ... [more ▼]

2D-DIGE analysis coupled with mass spectrometry is a global, without a priori, comparative proteomic approach particularly suited to identify and quantify enzymes isoforms and structural proteins, thus making it an efficient tool for the characterization of the changes in cell phenotypes that occur in physiological and pathological conditions. In this data article in support of the research article entitled “Metabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study” [1] we illustrate the changes in protein profile that occur during the metabolic reprogramming undergone by cultured mouse astrocytes in a model of in-vitro cancerous transformation [2]. [less ▲]

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See detailDual-use controls outreach: a new method
Michel, Quentin ULg; Paile, Sylvain ULg

in WorldECR (2015), (38), 27-28

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See detailEfficient finite element assembly of high order Whitney forms
Marsic, Nicolas ULg; Geuzaine, Christophe ULg

in IET Science, Measurement & Technology (2015), 9(2), 204-210

This study presents an efficient method for the finite element assembly of high order Whitney elements. The authors start by reviewing the classical assembly technique and by highlighting the most time ... [more ▼]

This study presents an efficient method for the finite element assembly of high order Whitney elements. The authors start by reviewing the classical assembly technique and by highlighting the most time consuming part. Then, they show how this classical approach can be reformulated into a computationally efficient matrix-matrix product. They also address the global orientation problem of the vector valued basis functions. They conclude by presenting numerical results for a three-dimensional wave propagation problem. [less ▲]

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See detailTargeting pericranial nerve branches to treat migraine: Current approaches and perspectives.
Ambrosini, Armin; D'Alessio, Costantino; MAGIS, Delphine ULg et al

in Cephalalgia : An International Journal of Headache (2015)

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See detailNecitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study.
Paz-Ares, Luis; Mezger, Jorg; Ciuleanu, Tudor E. et al

in The Lancet. Oncology (2015), 16(3), 328-37

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and ... [more ▼]

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung cancer (NSCLC). METHODS: We did this randomised, open-label, controlled phase 3 study at 103 sites in 20 countries. Patients aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 and adequate organ function, were randomly assigned 1:1 to treatment with a block randomisation scheme (block size of four) via a telephone-based interactive voice-response system or interactive web-response system. Patients received either cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2) on day 1 of a 3-week cycle for a maximum of six cycles alone, or with necitumumab 800 mg on days 1 and 8. Necitumumab was continued after the end of chemotherapy until disease progression or unacceptable toxic effects. Randomisation was stratified by smoking history, ECOG performance status, disease histology, and geographical region. Patients and study investigators were not masked to group assignment. The primary endpoint was overall survival. Efficacy analyses were by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00982111. FINDINGS: Between Nov 11, 2009, and Feb 2, 2011, we randomly assigned 633 patients to receive either necitumumab plus pemetrexed and cisplatin (n=315) or pemetrexed and cisplatin alone (n=318). Enrolment was stopped on Feb 2, 2011, after a recommendation from the independent data monitoring committee. There was no significant difference in overall survival between treatment groups, with a median overall survival of 11.3 months (95% CI 9.5-13.4) in the necitumumab plus pemetrexed and cisplatin group versus 11.5 months (10.1-13.1) in the pemetrexed and cisplatin group (hazard ratio 1.01 [95% CI 0.84-1.21]; p=0.96). The incidence of grade 3 or worse adverse events, including deaths, was higher in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group; in particular, deaths regarded as related to study drug were reported in 15 (5%) of 304 patients in the necitumumab group versus nine (3%) of 312 patients in the pemetrexed and cisplatin group. Serious adverse events were likewise more frequent in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group (155 [51%] of 304 vs 127 [41%] of 312 patients). Patients in the necitumumab plus pemetrexed and cisplatin group had more grade 3-4 rash (45 [15%] of 304 vs one [<1%] of 312 patients in the pemetrexed and cisplatin alone group), hypomagnesaemia (23 [8%] vs seven [2%] patients), and grade 3 or higher venous thromboembolic events (23 [8%] vs 11 [4%] patients) than did those in the pemetrexed and cisplatin alone group. INTERPRETATION: Our findings show no evidence to suggest that the addition of necitumumab to pemetrexed and cisplatin increases survival of previously untreated patients with stage IV non-squamous NSCLC. Unless future studies identify potentially useful predictive biomarkers, necitumumab is unlikely to provide benefit in this patient population when combined with pemetrexed and cisplatin. FUNDING: Eli Lilly and Company. [less ▲]

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See detailEvaluation des actions transversales du New Deal bruxellois
Cipriano, Sabrine; Fallon, Catherine ULg; Fastré, Perrine et al

in Les Cahiers de l'IBSA (2015), 4

En vue d’assurer la cohérence de la politique de l’emploi sur le territoire bruxellois, le volet transversal du « Pacte de Croissance Urbaine Durable », appelé aussi « New Deal » bruxellois, inventorie ... [more ▼]

En vue d’assurer la cohérence de la politique de l’emploi sur le territoire bruxellois, le volet transversal du « Pacte de Croissance Urbaine Durable », appelé aussi « New Deal » bruxellois, inventorie une série d’actions à mettre en œuvre de manière coordonnée. Pour cela, il définit un cadre permettant de développer des partenariats entre acteurs aussi différents que des administrations, des partenaires sociaux ou encore des cabinets ministériels, dépendant d’institutions tantôt régionales, tantôt communautaires, francophones ou néerlandophones. Il repense ainsi l’organisation de la coordination entre ces acteurs, sans pour autant toucher à la répartition institutionnelle des compétences sur le territoire bruxellois. L’évaluation présentée dans ce Cahier de l’IBSA livre un bilan de l’utilité de ces dispositifs de coordination, selon le point de vue des acteurs impliqués. Elle repose sur une comparaison de huit études de cas qui portent sur une période d’observation de trois ans, allant d’avril 2011 à mars 2014. L’évaluation met en lumière la nouvelle méthode de travail du New Deal qui permet, via des collaborations croisées, de dépasser certaines fragmentations politiques et institutionnelles autour de la question de l’emploi sur le territoire bruxellois. [less ▲]

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See detailRéflexions relatives au traitement des tendinopathies par infiltration de PRP
KAUX, Jean-François ULg; Bouvard, Marc; Sanchez, Mikel et al

in Journal de Traumatologie du Sport (2015), 32(1), 38-40

Introduction Platelet rich plasma injection (PRP) represents a recent therapy for chronic tendinopathies. However, this treatment remains controversial in clinical studies. Summary of the facts and ... [more ▼]

Introduction Platelet rich plasma injection (PRP) represents a recent therapy for chronic tendinopathies. However, this treatment remains controversial in clinical studies. Summary of the facts and results Based on literature and our experience, we offer few tracks in order to improve this treatment. The optimization of the technique of obtaining the PRP is paramount. Different risk factors must be corrected and the good indications carefully selected. Finally, a post-infiltration rehabilitation remains absolutely necessary. Conclusion Standardisation of the use of the PRP remains necessary in order to optimize the results. [less ▲]

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See detailWhat is important in being cured from: Does discordance between physicians and patients matter? (2)
Demyttenaere, Koen; Donneau, Anne-Françoise ULg; Albert, Adelin ULg et al

in Journal of Affective Disorders (2015), 174(2015), 372-377

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See detailEffect of storage and cooking on the fatty acid profile of omega-3 enriched eggs and pork meat marketed in Belgium
Douny, Caroline ULg; El Khoury, Rawad; Delmelle, Julien et al

in Food Science & Nutrition (2015), 3(2), 140-152

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See detailMagnetosphere-ionosphere mapping at Jupiter: Quantifying the effects of using different internal field models
Vogt, Marissa; Bunce, Emma; Kivelson, Margaret et al

in Journal of Geophysical Research. Space Physics (2015), 120

The lack of global field models accurate beyond the inner magnetosphere (<30 RJ) makes it difficult to relate Jupiter's polar auroral features to magnetospheric source regions. We recently developed a ... [more ▼]

The lack of global field models accurate beyond the inner magnetosphere (<30 RJ) makes it difficult to relate Jupiter's polar auroral features to magnetospheric source regions. We recently developed a model that maps Jupiter's equatorial magnetosphere to the ionosphere using a flux equivalence calculation that requires equal flux at the equatorial and ionospheric ends of flux tubes. This approach is more accurate than tracing field lines in a global field model but only if it is based on an accurate model of Jupiter's internal field. At present there are three widely used internal field models—Voyager Io Pioneer 4 (VIP4), the Grodent Anomaly Model (GAM), and VIP Anomaly Longitude (VIPAL). The purpose of this study is to quantify how the choice of an internal field model affects the mapping of various auroral features using the flux equivalence calculation. We find that different internal field models can shift the ionospheric mapping of points in the equatorial plane by several degrees and shift the magnetospheric mapping to the equator by ~30 RJ radially and by less than 1 h in local time. These shifts are consistent with differences in how well each model maps the Ganymede footprint, underscoring the need for more accurate Jovian internal field models. We discuss differences in the mapping of specific auroral features and the size and location of the open/closed field line boundary. Understanding these differences is important for the continued analysis of Hubble Space Telescope images and in planning for Juno's arrival at Jupiter in 2016. [less ▲]

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See detailTensor Representation of Spin States
Giraud, Olivier; Braun, Daniel; Baguette, Dorian ULg et al

in Physical Review Letters (2015), 114

We propose a generalization of the Bloch sphere representation for arbitrary spin states. It provides a compact and elegant representation of spin density matrices in terms of tensors that share the most ... [more ▼]

We propose a generalization of the Bloch sphere representation for arbitrary spin states. It provides a compact and elegant representation of spin density matrices in terms of tensors that share the most important properties of Bloch vectors. Our representation, based on covariant matrices introduced by Weinberg in the context of quantum field theory, allows for a simple parametrization of coherent spin states, and a straightforward transformation of density matrices under local unitary and partial tracing operations. It enables us to provide a criterion for anticoherence, relevant in a broader context such as quantum polarization of light. [less ▲]

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See detailPoly(vinyl ester 1,2,3-triazolium)s: a new member of the poly(ionic liquid)s family
Obadia, M. M.; Colliat-Dangus, G.; Debuigne, Antoine ULg et al

in Chemical Communications (2015), 51(16), 3332-3335

A vinyl ester monomer carrying a pendant 1,2,3-triazole group is synthesized in two steps and polymerized by cobalt-mediated radical polymerization. Subsequent alkylation with N-methyl bis ... [more ▼]

A vinyl ester monomer carrying a pendant 1,2,3-triazole group is synthesized in two steps and polymerized by cobalt-mediated radical polymerization. Subsequent alkylation with N-methyl bis[(trifluoromethyl)sulfonyl]imide affords the corresponding poly(vinyl ester 1,2,3-triazolium). This unprecedented example of poly(vinyl ester ionic liquid) exhibits an ionic conductivity of 9.2 × 10(-7) S cm(-1) at 30 °C [less ▲]

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See detailRetirement age and the age of onset of Alzheimer’s disease: Results from the ICTUS study
Grotz, Catherine ULg; Letenneur, Luc; Bonsang, Eric ULg et al

in PLoS ONE (2015)

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See detailLead concentrations and isotope ratios in speleothems as proxies for atmospheric metal pollution since the Industrial Revolution
Allan, Mohammed ULg; Fagel, Nathalie ULg; Van Rampelbergh, maite et al

in Chemical Geology (2015)

Lead concentrations and isotope ratios from two speleothems from the Han-sur-Lesse cave in southern Belgium were measured in order to study the ability of speleothems to act as archives of atmospheric ... [more ▼]

Lead concentrations and isotope ratios from two speleothems from the Han-sur-Lesse cave in southern Belgium were measured in order to study the ability of speleothems to act as archives of atmospheric pollution. To address this aim we analyzed trace elemental Al and Pb compositions by LA-ICP-MS and ICP-MS as well as Pb isotopes by MC-ICP-MS. The results help to identify three intervals characterized by particularly high enrichment of Pb: from 1880 to 1905 AD, from 1945 to 1965 AD, and from 1975 to 1990 AD. The speleothem record shows similar changes as the known historical atmospheric pollution level in Belgium. Lead isotope ratios discriminate between Pb sources and confirm that coal and gasoline combustion, combined with regional metallurgical activities, were the predominant Pb pollution sources in the stalagmites during the last 250 years. This study opens possibilities to determine anthropogenic versus natural metal sources in well-dated speleothem archives. [less ▲]

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See detailGranular transport in driven granular gas
Noirhomme, Martial ULg; Opsomer, Eric ULg; Ludewig, François ULg et al

in European Physical Journal E -- Soft Matter (2015), 38

We numerically and theoretically investigate the behavior of a granular gas driven by asymmetric plates. The injection of energy in the dissipative system differs from one side to the opposite one. We ... [more ▼]

We numerically and theoretically investigate the behavior of a granular gas driven by asymmetric plates. The injection of energy in the dissipative system differs from one side to the opposite one. We prove that the dynamical clustering which is expected for such a system is affected by the asymmetry. As a consequence, the cluster position can be fully controlled. This property could lead to various applications in the handling of granular materials in low-gravity environment. Moreover, the dynamical cluster is characterized by natural oscillations which are also captured by a model. These oscillations are mainly related to the cluster size, thus providing an original way to probe the clustering behavior. [less ▲]

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See detailProtection of Antarctic microbial communities–‘out of sight, out of mind’
Hughes, Kevin; Cowan, Don; Wilmotte, Annick ULg

in Frontiers in Microbiology (2015), 6(151), 1-6

RecentadvancesinmolecularbiologytechniqueshaveshownthepresenceofdiversemicrobialcommunitiesandendemicspeciesinAntarctica.Endemicmicrobesmaybeapotentialsourceofnovelbiotechnologicallyimportantcompounds ... [more ▼]

RecentadvancesinmolecularbiologytechniqueshaveshownthepresenceofdiversemicrobialcommunitiesandendemicspeciesinAntarctica.Endemicmicrobesmaybeapotentialsourceofnovelbiotechnologicallyimportantcompounds,including,forexample,newantibiotics.Thus,thescientificandbiotechnologicalvalueofAntarcticterrestrialmicrobialhabitatscanbecompromisedbyhumanvisitationtoagreaterextentthanpreviouslyrealized.Theever-increasinghumanfootprintinAntarcticamakesconsiderationofthistopicmorepressing,asthenumberoflocationsknowntobepristinehabitats,whereincreasinglysophisticatedcutting-edgeresearchtechniquesmaybeusedtotheirfullpotential,declines.ExaminationoftheProtectedAreassystemoftheAntarcticTreatyshowsthatmicrobialhabitatsaregenerallypoorlyprotected.NoothercontinentonEarthisdominatedtothesamedegreebymicrobialspecies,andrealopportunitiesexisttodevelopnewwaysofconceptualizingandimplementingconservationofmicrobialbiogeographyonacontinentalscale.Herewehighlightpotentialthreatsbothtotheconservationofterrestrialmicrobialecosystems,andtofuturescientificresearchrequiringtheirstudy. [less ▲]

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See detailResonant and antiresonant bouncing droplets
Hubert, Maxime ULg; Robert, Damien; Caps, Hervé ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015), 91

When placed onto a vibrating liquid bath, a droplet may adopt a permanent bouncing behavior, depending on both the forcing frequency and the forcing amplitude. The relationship between the droplet ... [more ▼]

When placed onto a vibrating liquid bath, a droplet may adopt a permanent bouncing behavior, depending on both the forcing frequency and the forcing amplitude. The relationship between the droplet deformations and the bouncing mechanism is studied experimentally and theoretically through an asymmetric and dissipative bouncing spring model. Antiresonance phenomena are evidenced. Experiments and theoretical predictions show that both resonance at specific frequencies and antiresonance at Rayleigh frequencies play crucial roles in the bouncing mechanism. In particular, we show that they could be exploited for bouncing droplet size selection. [less ▲]

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See detailTwo-Photon Luminescence of Gold Nanorods Mediated by Higher Order Plasmon Modes
Verellen, Niels; Denkova, Denitza; De Clercq, Ben et al

in ACS Photonics (2015), 2

Metallic nanorod antennas can be considered as an analogue to classical half-wave dipole antennas, constituting an important tool for manipulating linear and nonlinear lightmatter interactions in ... [more ▼]

Metallic nanorod antennas can be considered as an analogue to classical half-wave dipole antennas, constituting an important tool for manipulating linear and nonlinear lightmatter interactions in nanoscale volumes. Using two-photon luminescence (TPL) scanning laser microscopy, we investigate such optical antennas beyond their fundamental dipole mode. The antenna mode dispersion is extracted from the nonlinear TPL measurement and reveals a TPL process that is dominated by plasmon-induced enhancement of the two photon absorption in the metal. Additionally, a clear signature of the mode parity is observed in the TPL images. TPL maxima are observed outside the antenna boundaries for even parity modes, whereas they are located inside for odd modes. It is concluded that for even modes the two-photon luminescence emission is strongly mediated by retardation of the excitation field, a consequence of their zero net-dipole moment. This selective excitation of different mode parities is highly relevant for nanoscale enhanced nonlinear optics, as well as plasmonic nanosensor applications and tuning of radiative properties of quantum emitters. [less ▲]

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See detailGenetic Heterogeneicity and Clinical Variability in Musculo contractural Ehlers-Danlos syndrome caused by Impaired Dermatan Sulfate Biosynthesis
Syx, Delfien; Van Damme, Tim; Symoens, Sofie et al

in Human Mutation (2015), 36(5), 535-547

Bi-allelic variants in CHTS-14, encoding dermatan 4-O sulfotransferase-1(D4ST-1), cause musculocontractural Ehlers-Danlos syndrome (MC-EDS), a recessive disorder characterized by connective tissue ... [more ▼]

Bi-allelic variants in CHTS-14, encoding dermatan 4-O sulfotransferase-1(D4ST-1), cause musculocontractural Ehlers-Danlos syndrome (MC-EDS), a recessive disorder characterized by connective tissue fragility, craniofacial abnormalities, congenital contractures and developmental abnormalities. Recently, the identification of bi-allelic variants in DSE, encoding dermatan-sulfate epimerase-1(DS-epi1), in a child with MC-EDS features, suggested locus heterogeneity of this condition. DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondoitin sulfate (CS)/DS glycosaminoglycans (GAGs). Here, we report four novel families with severe MC-EDS caused by unique homozygous CHST14 variants and a second family with a homozygous DSE missense variant, presenting a somewhat milder MC-EDS phenotype. The glycanation of a dermal DS protoglycan decorin is impaired in fibroblasts from D4ST1, as well as DS-epi1-deficient patients. However, D4ST1-deficiency, decorin GAG is completely replaced by CS, whereas in DS-epi1-deficency, still some DS moieties are present. The multisystemic abnormalities observed in our patients support a tight spatiotemporal control of the balance between CS and DS, which is crucial for multiple processes including cell differentiation, organ development, cell migration, coagulation and connective tissue integrity. [less ▲]

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See detailTransient internally driven aurora at Jupiter discovered by Hisaki and the Hubble Space Telescope
Kimura, Tomoki; Badman, Sarah; Tao, Chihiro et al

in Geophysical Research Letters (2015), 42

Jupiter’s auroral emissions reveal energy transport and dissipation through the planet’s giant magnetosphere. While the main auroral emission is internally driven by planetary rotation in the steady state ... [more ▼]

Jupiter’s auroral emissions reveal energy transport and dissipation through the planet’s giant magnetosphere. While the main auroral emission is internally driven by planetary rotation in the steady state, transient brightenings are generally thought to be triggered by compression by the external solar wind. Here we present evidence provided by the new Hisaki spacecraft and the Hubble Space Telescope that shows that such brightening of Jupiter’s aurora can in fact be internally driven. The brightening has an excess power up to ~550 GW. Intense emission appears from the polar cap region down to latitudes around Io’s footprint aurora, suggesting a rapid energy input into the polar region by the internal plasma circulation process. [less ▲]

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See detailRational Development of an Attenuated Recombinant Cyprinid Herpesvirus 3 Vaccine Using Prokaryotic Mutagenesis and In Vivo Bioluminescent Imaging
Boutier, Maxime ULg; Ronsmans, Maygane ULg; Ouyang, Ping et al

in PLoS Pathogens (2015), 11(2), 1004690

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We ... [more ▼]

Cyprinid herpesvirus 3 (CyHV 3) is causing severe economic losses worldwide in common and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass vaccination is needed. We produced single deleted recombinants using prokaryotic mutagenesis. When producing a recombinant lacking open reading frame 134 (ORF134), we unexpectedly obtained a clone with additional deletion of ORF56 and ORF57. This triple deleted recombinant replicated efficiently in vitro and expressed an in vivo safety/efficacy profile compatible with use as an attenuated vaccine. To determine the role of the double ORF56-57 deletion in the phenotype and to improve further the quality of the vaccine candidate, a series of deleted recombinants was produced and tested in vivo. These experiments led to the selection of a double deleted recombinant lacking ORF56 and ORF57 as a vaccine candidate. The safety and efficacy of this strain were studied using an in vivo bioluminescent imaging system (IVIS), qPCR, and histopathological examination, which demonstrated that it enters fish via skin infection similar to the wild type strain. However, compared to the parental wild type strain, the vaccine candidate replicated at lower levels and spread less efficiently to secondary sites of infection. Transmission experiments allowing water contamination with or without additional physical contact between fish demonstrated that the vaccine candidate has a reduced ability to spread from vaccinated fish to naïve sentinel cohabitants. Finally, IVIS analyses demonstrated that the vaccine candidate induces a protective mucosal immune response at the portal of entry. Thus, the present study is the first to report the rational development of a recombinant attenuated vaccine against CyHV 3 for mass vaccination of carp. We also demonstrated the relevance of the CyHV 3 carp model for studying alloherpesvirus transmission and mucosal immunity in teleost skin. [less ▲]

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See detailDynamic Input Conductances Shape Neuronal Spiking
Drion, Guillaume ULg; Franci, Alessio ULg; Dethier, Julie ULg et al

in eNeuro (2015)

Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness and homeostasis of neuronal signaling. The paper proposes that this ... [more ▼]

Assessing the role of biophysical parameter variations in neuronal activity is critical to the understanding of modulation, robustness and homeostasis of neuronal signaling. The paper proposes that this question can be addressed through the analysis of dynamic input conductances. Those voltage-dependent curves aggregate the concomitant activity of all ion channels in distinct timescales. They are shown to shape the current-voltage dynamical relationships that determine neuronal spiking. We propose an experimental protocol to measure dynamic input conductances in neurons. In addition, we provide a computational method to extract dynamic input conductances from arbitrary conductance-based models and to analyze their sensitivity to arbitrary parameters. We illustrate the relevance of the proposed approach for modulation, compensation and robustness studies in a published neuron model based on data of the stomatogastric ganglion of the crab Cancer borealis. [less ▲]

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See detailDUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis
Musumeci, Lucia ULg; Kuijpers, Marijke; Gilio, Karen et al

in Circulation (2015), 131(7), 656-68

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet ... [more ▼]

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet activation is of importance for the development of improved therapies. Recently, protein tyrosine phosphatases (PTPs) have emerged as critical regulators of platelet function. Methods and Results This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signaling and thrombosis. This phosphatase is highly expressed in human and mouse platelets. Platelets from DUSP3-deficient mice displayed a selective impairment of aggregation and granule secretion mediated through the collagen receptor glycoprotein VI (GPVI) and the C-type lectin-like receptor 2 (CLEC-2). DUSP3-deficient mice were more resistant to collagen- and epinephrine-induced thromboembolism, compared to wild-type mice, and showed severely impaired thrombus formation upon ferric chloride-induced carotid artery injury. Intriguingly, bleeding times were not altered in DUSP3-deficient mice. At the molecular level, DUSP3 deficiency impaired Syk tyrosine phosphorylation, subsequently reducing phosphorylation of PLCγ2 and calcium fluxes. To investigate DUSP3 function in human platelets, a novel small-molecule inhibitor of DUSP3 was developed. This compound specifically inhibited collagen and CLEC-2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells. Conclusions DUSP3 plays a selective and essential role in collagen- and CLEC-2-mediated platelet activation and thrombus formation in vivo. Inhibition of DUSP3 may prove therapeutic for arterial thrombosis. This is the first time a PTP, implicated in platelet signaling, has been targeted with a small-molecule drug. [less ▲]

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