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See detailDistribution of heavy and clay minerals in coastal sediment of jijel, East of Algeria: indicators of sediment sources and transport and deposition environments
KERMANI, S.; BOUTIBA, M.; BOUTALEB, A. et al

in Arabian Journal of Geosciences (2016)

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See detailA consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis - From evidence-based medicine to the real-life setting.
Bruyère, Olivier ULg; Cooper, C.; Pelletier, J.P. et al

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 3-11

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides ... [more ▼]

The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis(ESCEO) published a treatment algorithm for the management of knee osteoarthritis (OA) in 2014,which provides practical guidance for the prioritization of interventions. Further analysis of real-world data for OA provides additional evidence in support of pharmacological interventions,in terms of management of OA pain and function, avoidance of adverse events, disease-modifying effects and long-term outcomes, e.g., delay of total joint replacement surgery, and pharmacoeconomic factors such as reduction in healthcare resource utilization. This article provides an updated assessment of the literature for selected interventions in OA, focusing on real-life data, with the aim of providing easy-to-follow advice on how to establish a treatment flow in patients with knee OA in primary care clinical practice, in support of the clinicians’ individualized assessment of the patient. In step 1, background maintenance therapy with symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) is recommended, for which high-quality evidence is provided only for the prescription formulations of patented crystalline glucosamine sulfate and chondroitin sulfate. Paracetamol may be added for rescue analgesia only,due to limited efficacy and increasing safety signals. Topical non-steroidal anti-inflammatory drugs (NSAIDs) may provide additional symptomatic treatment with the same degree of efficacy as oral NSAIDs without the systemic safety concerns. Oral NSAIDs maintain a central role in step2 Advanced management of persistent symptoms. However, oral NSAIDs are highly heterogeneous in terms of gastrointestinal and cardiovascular safety profile, and patient stratification with careful treatment selection is advocated to maximize the risk: benefit ratio. Intra-articular hyaluronic acid as a next step provides sustained clinical benefit with effects lasting up to 6 months after a short-course of weekly injections. As a last step before surgery, thes low titration of sustained-release tramadol, aweak opioid, affords sustained analgesia with improved tolerability. [less ▲]

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See detailInfluence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with limited oxygen transfer rate.
Carly, F.; Niu, H.; Delvigne, Frank ULg et al

in Journal of industrial microbiology & biotechnology (2016), 43(4), 517-23

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen ... [more ▼]

High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen limitation in bioreactor. In the literature, there is lack of report about AOX1 promoter regulation with regard to dissolved oxygen level (DO). Therefore, in this work, chemostat cultures were performed to investigate the cell growth, metabolism and regulation of the AOX1 promoter (pAOX1) regarding co-feeding rate of optimized methanol/sorbitol mixture (methanol fraction 0.60 C-mol/C-mol) using a P. pastoris Mut+/pAOX1-lacZ strain. The oxygen transfer rates (OTR) in bioreactor were kept in the range of typical values of large bioreactor, i.e., 4-8 g/(L h) if DO equals 30 % saturation or 5-10 g/(L h) if DO nears zero. For DO >0, an increase of the carbon fed led to an increase of pAOX1 induction. By contrast, when dissolved oxygen was completely depleted, methanol accumulated, causing a 30 % decrease of pAOX1 induction. However, this decrease is more likely to be lined to methanol accumulation than to low level of dissolved oxygen (<4 % DO). Methanol/sorbitol co-feeding allowed cells to adapt to oxygen transient limitations that often occur at industrial scale with reduced effect on pAOX1 induction. The optimal feeding rate tested here was 6.6 mmol C (DCW h)(-1) at an OTR of 8.28 g O2(L h)(-1) with over fivefold pAOX1 induction (probably directly associated with target protein productivity) compared with previous work. [less ▲]

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See detailPoliteal vein blood sampling and the post-mortem redistribution of diazepam, methadone and morphine
Lemaire, Eric ULg; Schmidt, C.; DENOOZ, Raphael ULg et al

in Journal of Forensic Sciences (2016)

Postmortem redistribution (PMR) refers to the site- and time-related blood drug concentration variations after death. We compared central blood (cardiac and subclavian) with peripheral blood (femoral and ... [more ▼]

Postmortem redistribution (PMR) refers to the site- and time-related blood drug concentration variations after death. We compared central blood (cardiac and subclavian) with peripheral blood (femoral and popliteal) concentrations of diazepam, methadone, and morphine. To our knowledge, popliteal blood has never been compared with other sites. Intracardiac blood (ICB), subclavian blood (SB), femoral blood (FB), and popliteal blood (PB) were sampled in 30 cases. To assess PMR, mean concentrations and ratios were compared. Influence of postmortem interval on mean ratios was also assessed. Results show that popliteal mean concentrations were lower than those for other sites for all three drugs, even lower than femoral blood; mean ratios suggested that the popliteal site was less subject to PMR, and estimated postmortem interval did not influence ratios except for diazepam and methadone FB/PB. In conclusion, our study is the first to explore the popliteal site and suggests that popliteal blood is less prone to postmortem redistribution. [less ▲]

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See detailWhat Is the Role of Minimally Invasive Mitral Valve Surgery in High-Risk Patients? A Meta-Analysis of Observational Studies.
Moscarelli, Marco; Fattouch, Khalil; Casula, Roberto et al

in The Annals of thoracic surgery (2016)

BACKGROUND: Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. METHODS: A ... [more ▼]

BACKGROUND: Minimally invasive valve surgery is related to certain better postoperative outcomes. We aimed to assess the role of minimally invasive mitral valve surgery in high-risk patients. METHODS: A systematic literature review identified eight studies of which seven fulfilled criteria for meta-analysis. Outcomes for a total of 1,254 patients (731 were conventional standard sternotomy and 523 were minimally invasive mitral valve surgery) were submitted to meta-analysis using random effects modeling. Heterogeneity and subgroup analysis with quality scoring were assessed. The primary end point was early mortality. Secondary end points were intraoperative and postoperative outcomes and long-term follow-up. RESULTS: Minimally invasive mitral valve surgery conferred comparable early mortality to standard sternotomy (p = 0.19); it was also associated with a lower number of units of blood transfused (weighted mean difference, -1.93; 95% confidence interval [CI], -3.04 to -0.82; p = 0.0006) and atrial fibrillation rate (odds ratio, 0.49; 95% CI, 0.32 to 0.74; p = 0.0007); however, cardiopulmonary bypass time was longer (weighted mean difference, 20.88; 95% CI, -1.90 to 43.65; p = 0.07). There was no difference in terms of valve repair rate (odds ratio, 1.51; 95% CI, 0.89 to 2.54; p = 0.12), and the incidence of stroke was significantly lower in the high-quality analysis with no heterogeneity (odds ratio, 0.35; 95% CI, 0.15 to 0.82; p = 0.02; chi2, 1.67; I2, 0%; p = 0.43). CONCLUSIONS: Minimally invasive mitral valve surgery is a safe and comparable alternative to standard sternotomy in patients at high risk, with similar early mortality and repair rate and better postoperative outcomes, although a longer cardiopulmonary bypass time is required. [less ▲]

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See detailMechanical behaviour of tape springs used in the deployment of reflectors around a solar panel
Dewalque, Florence ULg; Collette, Jean-Paul; Bruls, Olivier ULg

in Acta Astronautica (2016), 123

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this ... [more ▼]

In order to increase the production of power on small satellites, solar panels are commonly deployed and, in some cases, reflectors are added to improve the concentration factor on solar cells. In this work, reflectors are deployed by the means of compliant mechanisms known as tape springs. Their attractive characteristics are, among others, their passive behaviour, their self-locking capacity, their elastic deformations and their robustness. However, their mechanical behaviour is highly nonlinear and requires thorough analyses in order to develop predictive numerical models. It is shown here through parametric studies that the nonlinear behaviour of a tape spring is mainly governed by its geometry. Thus, for each specific application, its dimensions can be determined in order to minimise two critical features: the maximum stress affecting the structure and the maximum motion amplitude during deployment. In this paper, an optimisation procedure is proposed to meet these requirements. [less ▲]

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See detailStructural Proteomics of Herpesviruses.
Leroy, Baptiste; Gillet, Laurent ULg; Vanderplasschen, Alain ULg et al

in Viruses (2016), 8(2),

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have ... [more ▼]

Herpesviruses are highly prevalent viruses associated with numerous pathologies both in animal and human populations. Until now, most of the strategies used to prevent or to cure these infections have been unsuccessful because these viruses have developed numerous immune evasion mechanisms. Therefore, a better understanding of their complex lifecycle is needed. In particular, while the genome of numerous herpesviruses has been sequenced, the exact composition of virions remains unknown for most of them. Mass spectrometry has recently emerged as a central method and has permitted fundamental discoveries in virology. Here, we review mass spectrometry-based approaches that have recently allowed a better understanding of the composition of the herpesvirus virion. In particular, we describe strategies commonly used for proper sample preparation and fractionation to allow protein localization inside the particle but also to avoid contamination by nonstructural proteins. A collection of other important data regarding post-translational modifications or the relative abundance of structural proteins is also described. This review also discusses the poorly studied importance of host proteins in herpesvirus structural proteins and the necessity to develop a quantitative workflow to better understand the dynamics of the structural proteome. In the future, we hope that this collaborative effort will assist in the development of new strategies to fight these infections. [less ▲]

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See detailRecording and Reading Alchemy and Art-Technology in Medieval and Premodern German Recipe Collections
Neven, Sylvie ULg

in Nuncius. Journal of the Material and Visual History of Science (2016)

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See detailHuman norovirus infection in Latin America
da Silva Polo, Tatiane; Peiro, Juliana; Claudio Nogueira Mendes, Luiz et al

in Journal of Clinical Virology (2016), 78

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See detailLa pensée future épisodique : entre simulation et contexte autobiographique
D'Argembeau, Arnaud ULg

in Revue de Neuropsychologie (2016), 8

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See detailBiotic homogenization can decrease landscape-scale forest multifunctionality
van der Plas, Fons; Manning, Pete; Soliveres, Santiago et al

in Proceedings of the National Academy of Sciences (2016)

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of ... [more ▼]

Many experiments have shown that local biodiversity loss impairs the ability of ecosystems to maintain multiple ecosystem functions at high levels (multifunctionality). In contrast, the role of biodiversity in driving ecosystem multifunctionality at landscape scales remains unresolved. We used a comprehensive pan-European dataset, including 16 ecosystem functions measured in 209 forest plots across six European countries, and performed simulations to investigate how local plot-scale richness of tree species (α-diversity) and their turnover between plots (β-diversity) are related to landscape-scale multifunctionality. After accounting for variation in environmental conditions, we found that relationships between α-diversity and landscape-scale multifunctionality varied from positive to negative depending on the multifunctionality metric used. In contrast, when significant, relationships between β-diversity and landscape-scale multifunctionality were always positive, because a high spatial turnover in species composition was closely related to a high spatial turnover in functions that were supported at high levels. Our findings have major implications for forest management and indicate that biotic homogenization can have previously unrecognized and negative consequences for large-scale ecosystem multifunctionality. [less ▲]

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See detailThe effect of insulin on plasma glucose concentrations, expression of hepatic glucose transporters and key gluconeogenic enzymes during the perinatal period in broiler chickens
Franssens, L.; Lesuisse, J.; Wang, Yuan ULg et al

in General and Comparative Endocrinology (2016)

Chickens have blood glucose concentrations that are twofold higher than those observed in mammals. Moreover, the insulin sensitivity seems to decrease with postnatal age in both broiler and layer chickens ... [more ▼]

Chickens have blood glucose concentrations that are twofold higher than those observed in mammals. Moreover, the insulin sensitivity seems to decrease with postnatal age in both broiler and layer chickens. However, little is known about the response of insulin on plasma glucose concentrations and mRNA abundance of hepatic glucose transporters 1, 2, 3, 8, 9 and 12 (GLUT1, 2, 3, 8, 9 and 12) and three regulatory enzymes of the gluconeogenesis, phosphoenolpyruvate carboxykinase 1 and 2 (PCK1 and 2) or fructose-1,6-biphosphatase 1 (FBP1) in chicks during the perinatal period. In the present study, broiler embryos on embryonic day (ED)16, ED18 or newly-hatched broiler chicks were injected intravenously with bovine insulin (1. μg/g body weight (BW)) to examine plasma glucose response and changes in hepatic mRNA abundance of the GLUTs, PCK1 and 2 and FBP1. Results were compared with a non-treated control group and a saline-injected sham group. Plasma glucose levels of insulin-treated ED18 embryos recovered faster from their minimum level than those of insulin-treated ED16 embryos or newly-hatched chicks. In addition, at the minimum plasma glucose level seven hours post-injection (PI), hepatic GLUT2, FBP1 and PCK2 mRNA abundance was decreased in insulin-injected embryos, compared to sham and control groups, being most pronounced when insulin injection occurred on ED16. © 2015 Elsevier Inc. [less ▲]

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See detailApport du cathétérisme cardiaque dans le diagnostic et le traitement de la maladie coronarienne avant 40 ans
MEURICE, Caroline; LEGRAND, Victor ULg; PIERARD, Luc ULg

in Revue Médicale de Liège (2016), 71(3), 129-136

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See detailGemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 Trial
Amadori, Sergio; Suciu, Stefan; Selleslag, Dominik et al

in Journal of Clinical Oncology (2016)

Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for ... [more ▼]

Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for intensive chemotherapy. Patients and Methods In this trial, patients at least 61 years old were centrally randomized (1:1) to receive either a single induction course of GO (6 mg/m2 on day 1 and 3 mg/m2 on day 8) or BSC. Patients who did not progress after GO induction could receive up to eight monthly infusions of the immunoconjugate at 2 mg/m2. Randomization was stratified by age, WHO performance score, CD33 expression status, and center. The primary end point was overall survival (OS) by intention-to-treat analysis. Results A total of 237 patients were randomly assigned (118 to GO and 119 to BSC). The median OS was 4.9 months (95% CI, 4.2 to 6.8 months) in the GO group and 3.6 months (95% CI, 2.6 to 4.2 months) in the BSC group (hazard ratio, 0.69; 95% CI, 0.53 to 0.90; P = .005); the 1-year OS rate was 24.3% with GO and 9.7% with BSC. The OS benefit with GO was consistent across most subgroups, and was especially apparent in patients with high CD33 expression status, in those with favorable/intermediate cytogenetic risk profile, and in women. Overall, complete remission (CR [complete remission] + CRi [CR with incomplete recovery of peripheral blood counts]) occurred in 30 of 111 (27%) GO recipients. The rates of serious adverse events (AEs) were similar in the two groups, and no excess mortality from AEs was observed with GO. Conclusion First-line monotherapy with low-dose GO, as compared with BSC, significantly improved OS in older patients with acute myeloid leukemia who were ineligible for intensive chemotherapy. No unexpected AEs were identified and toxicity was manageable. [less ▲]

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See detailApoptosis of Sertoli cells after conditional ablation of murine double minute 2 (Mdm2) gene is p53-dependent and results in male sterility.
Fouchecourt, S.; Livera, G.; Messiaen, S. et al

in Cell death and differentiation (2016)

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction ... [more ▼]

Beside its well-documented role in carcinogenesis, the function of p53 family has been more recently revealed in development and female reproduction, but it is still poorly documented in male reproduction. We specifically tested this possibility by ablating Mdm2, an E3 ligase that regulates p53 protein stability and transactivation function, specifically in Sertoli cells (SCs) using the AMH-Cre line and created the new SC-Mdm2-/- line. Heterozygous SC-Mdm2-/+ adult males were fertile, but SC-Mdm2-/- males were infertile and exhibited: a shorter ano-genital distance, an extra duct along the vas deferens that presents a uterus-like morphology, degenerated testes with no organized seminiferous tubules and a complete loss of differentiated germ cells. In adults, testosterone levels as well as StAR, P450c17 (Cyp17a1) and P450scc (Cyp11a1) mRNA levels decreased significantly, and both plasma LH and FSH levels increased. A detailed investigation of testicular development indicated that the phenotype arose during fetal life, with SC-Mdm2-/- testes being much smaller at birth. Interestingly, Leydig cells remained present until adulthood and fetal germ cells abnormally initiated meiosis. Inactivation of Mdm2 in SCs triggered p53 activation and apoptosis as early as 15.5 days post conception with significant increase in apoptotic SCs. Importantly, testis development occurred normally in SC-Mdm2-/- lacking p53 mice (SC-Mdm2-/-p53-/-) and accordingly, these mice were fertile indicating that the aforementioned phenotypes are entirely p53-dependent. These data not only highlight the importance of keeping p53 in check for proper testicular development and male fertility but also certify the critical role of SCs in the maintenance of meiotic repression.Cell Death and Differentiation advance online publication, 16 October 2015; doi:10.1038/cdd.2015.120. [less ▲]

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See detailCombined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et al

in Ann Rheum Dis (2016), 75(1), 37-44

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]

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See detailCholesterol deficiency causing calf illthrift and diarrhoea.
Duff, J. P.; Passant, S.; Wessels, M. et al

in The Veterinary record (2016), 178(17), 424-5

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See detailFacteurs pronostiques du cancer pulmonaire non à petites cellules
GESTER, Fanny; PAULUS, Astrid ULg; SIBILLE, Anne ULg et al

in Revue Médicale de Liège (2016), 71(1), 34-39

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of ... [more ▼]

Summary : Non small cell lung cancer is the most frequent type of lung cancer and its prognosis is still very poor. Relapse is frequent and can be observed even in early stages of the disease, in spite of a surgical management with curative intent. This paper gives an overview of the main prognostic factors, the two most important of which remain the staging and tumor histology. These also determine the therapeutic strategy. Other factors of poor prognosis might also be useful for clinicians, particularly in their decision to refer patients for adjuvant therapies. Keywords : Non-small cell lung cancer – Prognostic factors – Pulmonary oncology – Surgery [less ▲]

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See detailL'impôt sur les revenus des salariés et l'extranéité (1e partie)
Docclo, Caroline ULg

in Journal des Tribunaux du Travail (2016)

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See detailComparative virucidal efficacy of seven disinfectants against murine norovirus and feline calicivirus, surrogates of human norovirus
Zonta, William ULg; Mauroy, Axel ULg; Farnir, Frédéric ULg et al

in Food and Environmental Virology (2016)

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge ... [more ▼]

Human noroviruses (HuNoV) are the leading cause of acute nonbacterial gastroenteritis in humans and can be transmitted either by person-to-person contact or by consumption of contaminated food. Knowledge of an efficient disinfection for both hands and food contact surfaces is helpful for the food sector and provides precious information for public health. The aim of this study was to evaluate the effect of seven disinfectants belonging to different groups of biocides (alcohol, halogen, oxidizing agents, quaternary ammonium compounds, aldehyde and biguanide) on infectious viral titre and on genomic copy number. Due to the absence of a cell culture system for HuNoV, two HuNoV surrogates such as murine norovirus (MNV) and feline calicivirus (FCV), were used and the tests were performed in suspension, on gloves and on stainless steel discs. When, as criteria of efficacy, a log reduction > 3 of the infectious viral titre on both surrogates and in the three tests is used, the most efficacious disinfectants in this study appear to be biocidal products B, C and D, representing the halogens, the oxidizing agents group and a mix of QAC, alcohol and aldehyde, respectively. In addition, these three disinfectants also elicited a significant effect on genomic copy number for both surrogate viruses and in all three tests. The results of this study demonstrate that a halogen compound, oxidizing agents and a mix of QAC, alcohol and aldehyde are advisable for HuNoV disinfection of either potentially contaminated surfaces or materials in contact with foodstuffs. [less ▲]

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See detailGender effect on the scapular 3D posture and kinematic in healthy subjects
Schwartz, Cédric ULg; Croisier, Jean-Louis ULg; Rigaux, Elise et al

in Clinical Physiology and Functional Imaging (2016)

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However ... [more ▼]

Populations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapula-thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno-humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation were significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero-thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behavior of men and women should not be expected to be similar. [less ▲]

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See detailVALIDATION OF THE FRENCH VERSION OF THE PARENTING STRESS INDEX–SHORT FORM (FOURTH EDITION)
Toucheque, Malorie ULg; Etienne, Anne-Marie ULg; Stassart, Céline ULg et al

in Journal of Community Psychology (2016), 44(4), 419-425

Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth ... [more ▼]

Introduction: The Parenting Stress Index (PSI) is widely used to measure stress related to the demands of parenthood. Unfortunately, no French adaptation and validation of the PSI Short Form (Fourth Edition) had yet been published. This study examine the factor structure and the psychometric properties of the French translation of the PSI-4-SF. Method: Sample consists of 210 parents of children aged 5 to 12 years old. Factor structure of the PSI-4-SF was investigated using confirmatory factor analysis (CFA). Three models were tested, with one, two and three dimensions. Internal consistency reliability and validity were also examined. Results: CFA showed that the original three-factor solution most closely approximated our data despite the imperfection of the model fit indices. Results also indicated a good internal consistency reliability and validity. Conclusion: The French version of the PSI-4-SF shows promise as a valuable instrument for assessing parenting stress in the French-speaking population. [less ▲]

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See detailAccelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Raibaut, Laurent; Cargoët, Marine; Ollivier, Nathalie et al

in Chemical Science (2016)

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis ... [more ▼]

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis(2-selenylethyl)amido (SeEA) group, i.e. the selenium analog of the bis(2-sulfanylethyl)amido (SEA) group, for accelerating peptide bond formation. A chemoselective exchange process operating in water was devised for converting SEA peptides into the SeEA ones. Kinetic studies show that SeEA ligation, which relies on an initial N,Se-acyl shift process, proceeds significantly faster than SEA ligation. This property enabled the design of a kinetically controlled three peptide segment assembly process based on the sequential use of SeEA and SEA ligation reactions. The method was validated by the total synthesis of hepatocyte growth factor K1 (85 AA) and biotinylated NK1 (180 AA) domains [less ▲]

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See detail2015 ESC Guidelines for the management of infective endocarditis.
Habib, Gilbert; LANCELLOTTI, Patrizio ULg; Antunes, Manuel J. et al

in Revista espanola de cardiologia (English ed.) (2016), 69(1), 69

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See detailDe la matérialisation de quelques concepts phénoménologiques.
Frère, Bruno ULg

in SociologieS (2016)

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été ... [more ▼]

Résumé : Ce article suggère une réflexion sur les rapports qu’entretiennent sociologie et philosophie. Il entend montrer qu’établir des ponts entre les deux disciplines a non seulement toujours été d’usage mais s’avère aujourd’hui urgent. En effet, faisant l’économie d’une considération sérieuse de la prise que lui offre la sociologie sur le monde, la philosophie risque d’échouer à penser les transformations politiques et économiques des société contemporaines. A l’inverse, une certaine tendance positiviste semble menacer la sociologie qui se débarrasserait de toutes connaissances philosophiques. Afin de rappeler l’intérêt que l’une et l’autre se doivent réciproquement, cet article voudrait montrer comment il peut être utile à la sociologie de donner corps à certains concepts philosophiques lorsqu’elle s’avère confrontée à certaines difficultés. Afin d’illustrer le propos, nous nous référerons à un exemple puisé au sein de l’économie solidaire. Ici en effet, c’est en acceptant que se matérialise dans l’enquête le concept d’état d’esprit intentionnel que la philosophie phénoménologique vient à point nommé pour aider la sociologie pragmatique de la critique à se représenter les contradictions qui peuvent apparaître entre action et justification. Et ce sans pour autant renoncer à « prendre les gens aux sérieux » et s’en retourner vers une traditionnelle sociologie du dévoilement qui expliquerait ces contradictions par le décalage qui existerait entre habitus (ou sens pratique) d’une part et illusions réflexives des acteurs d’autre part. Mots clefs : phénoménologie, états d’esprit intentionnel, philosophie, sociologie pragmatique, économie solidaire. Summary : This article is a reflexion about the relationship between sociology and philosophy. It will show that building bridges between the two disciplines, whilst recurrent, is more urgent now than ever. On the one hand, philosophy will be unable to contribute meaningfully to discussions about the major political and economic transformations experienced by contemporary societies without engaging with Sociology. On the other hand without philosophical insights Sociology risks drifting towards positivistic trends. In this article we propose to show how each discipline can benefit from cross-fertilisations and in particular how Sociology can appropriate philosophical concepts to address certain challenges. Drawing on a specific example from solidary economy, we will show that the concept of intentional mindset borrowed from phenomenological philosophy enables pragmatic sociology to account for the gaps which are liable to emerge between action and justification. This concept fulfills the key tenet of pragmatic sociology that to take social actors seriously we must eschew a type of sociological approach which would consist of revealing that the gaps between action and justification arise from social actors’ illusory apprehension of their habitus. Key words: phénoménology, mindset, states of mind, philosophy, pragmatic sociology, solidarity economy. [less ▲]

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See detailAdaptation et neurosciences I : craintes, société, méthodologie, finalité
Desseilles, Martin ULg

in Santé Mentale au Québec (2016), XL(3), 209-221

Cetarticleestlepremierdedeuxarticlesexplorantlesliensbidirection- nels entre le concept d’adaptation et celui de neurosciences. Nous verrons tout d’abord dans cet article que les neurosciences peuvent ... [more ▼]

Cetarticleestlepremierdedeuxarticlesexplorantlesliensbidirection- nels entre le concept d’adaptation et celui de neurosciences. Nous verrons tout d’abord dans cet article que les neurosciences peuvent être perçues comme ambi- tieuses et toutes-puissantes oscillant entre un danger réductionniste et déshuma- nisant ou bien cristallisant certains fantasmes de maîtrise. Nous verrons ensuite que la société s’adapte aux neurosciences en intégrant certaines méthodologies et certaines découvertes dans des domaines très variés, au point que nous pouvons nous questionner sur la neurosociété de demain. Ensuite nous verrons que la méthodologie des neurosciences est elle-même fréquemment remise en question et nécessite que chacun en connaisse les limites sans s’en tenir aux seules pro- messes. Après cela, nous verrons que l’adaptation vue comme une promesse d’un but déterminé et fini peut s’avérer rassurante mais est surtout improbable. [less ▲]

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See detailA new numerical framework for simulating the control of weather and climate on the evolution of soil-mantled hillslopes
Bovy, Benoît ULg; Braun, Jean; Demoulin, Alain ULg

in Geomorphology (2016), 263

We present a new numerical framework for simulating short to long-term hillslope evolution. This modeling framework, to which we have given the name CLICHE (CLImate Control on Hillslope Evolution), aims ... [more ▼]

We present a new numerical framework for simulating short to long-term hillslope evolution. This modeling framework, to which we have given the name CLICHE (CLImate Control on Hillslope Evolution), aims to better capture the control of climate on soil dynamics. It allows the use of realistic forcing that involves, through a specific time discretization scheme, the variability of both the temperature and precipitation at time scales ranging from the daily rainfall events to the climatic oscillations of the Quaternary, also including seasonal variability. Two simple models of soil temperature and soil water balance permit the link between the climatic inputs and derived quantities that take part in the computation of the soil flux, such as the surface water discharge and the depth of the non-frozen soil layer. Using this framework together with a multi-process parameterization of soil transport, we apply an original method to calculate hillslope effective diffusivity as a function of climate. This allows us to demonstrate the ability of the model to simulate observed rates of hillslope erosion under different climates (cold and temperate) with a single set of parameter values. Numerical experiments furthermore suggest a potential high peak of sediment transport on hillslopes during the glacialinterglacial transitions of the Quaternary. We finally discuss the need to improve the parameterization of the soil production and transport processes in order to explicitly account for other key controlling factors that are also climate-sensitive, such as biological activity. [less ▲]

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See detailBrentano, la théorie des catégories et la définition de la substance
Boccaccini, Federico ULg

in Etudes Philosophiques (2016)

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See detailBott type periodicity for the higher octonions
Kreusch, Marie ULg

in Journal of Noncommutative Geometry (2016), 9(4), 1041-1393

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions ... [more ▼]

We study the series of complex nonassociative algebras $\bbO_n$ and real nonassociative algebras $\bbO_{p,q}$ introduced in~\cite{MGO2011}. These algebras generalize the classical algebras of octonions and Clifford algebras. The algebras $\bbO_{n}$ and $\bbO_{p,q}$ with $p+q=n$ have a natural $\Z_2^n$-grading, and they are characterized by cubic forms over the field $\Z_2$. We establish a periodicity for the algebras~$\bbO_{n}$ and $\bbO_{p,q}$ similar to that of the Clifford algebras $\mathrm{Cl}_{n}$ and~$\mathrm{Cl}_{p,q}$. [less ▲]

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See detailWhat drives the development of community energy in Europe? The case of wind power cooperatives
Bauwens, Thomas ULg; Gotchev, Boris; Holstenkamp, Lars

in Energy Research & Social Science (2016), 13

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being ... [more ▼]

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being paid to the transition process towards a more decentralized configuration. This article examines the factors likely to foster citizen and community participation as regards wind power cooperatives in Denmark, Germany, Belgium and the UK. Using Elinor Ostrom’s Social-Ecological System Framework, the analysis highlights a double-edged phenomenon: prevailing and growing hostility towards cooperatives, on the one hand, and, on the other, strategic reactions to this evolution. What comes out indeed is that, throughout most of these countries, the emergence of some coordinated inter-organizational actions among cooperatives enables them to survive in their critical environment. [less ▲]

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See detailContinuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Di Marco, Lorenzo; Hans, Morgan; Delaude, Lionel ULg et al

in Chemistry : A European Journal (2016), 22

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a ... [more ▼]

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homoge¬neous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions, namely, the transesterification of vinyl acetate with benzyl alcohol and the amidation of N-Boc-glycine methyl ester with ethanolamine. Both organocatalytic transfor¬ma¬tions proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs. [less ▲]

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See detailAbelian bordered factors and periodicity
Charlier, Emilie ULg; Harju, Tero; Puzynina, Svetlana et al

in European Journal of Combinatorics (2016), 51

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only ... [more ▼]

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only if it contains only finitely many unbordered factors. We are interested in abelian and weak abelian analogues of this result; namely, we investigate the following question(s): Let w be an infinite word such that all sufficiently long factors are (weakly) abelian bordered; is w (weakly) abelian periodic? In the process we answer a question of Avgustinovich et al. concerning the abelian critical factorization theorem. [less ▲]

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See detail« La Théorie critique n’a aucun rapport avec la société. » Kluge, Adorno et l’indomptable Leni Peickert
Hamers, Jérémy ULg; Cormann, Grégory ULg

in Tijdschrift voor Filosofie (2016)

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to ... [more ▼]

In Artists Under the Big Top: Perplexed (1968), Alexander Kluge’s second feature film, as well as in its short sequel The Indomitable Leni Peickert (1969), the filmmaker reflects about the possibility to create a « reformed circus » which aims at reintroducing some sensuality in the spectator’s experience. Taking this project as well as its central figure, the apparently passive elephant, as a metaphorical starting point, this article reconstitutes a virtual dialogue between the filmmaker and his friend and former master Theodor W. Adorno around the issue of communicability and effectiveness of Critical Theory. Crossing several text fragments by the philosopher (Dialectic of Enlightenment, Resignation and Education After Auschwitz a.o.) with film excerpts, short stories and interviews by Kluge, this dialogue made of real exchanges, as well as direct and indirect quotes of Adorno in Kluge’s films – considered here to be belated joint projects –, finally tries to give an answer to following crucial question: how can Adorno’s critical reflection remain politically, that is socially effective. [less ▲]

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See detailYellow nail syndrome after allogeneic haematopoietic stem cell transplantation in two patients with multiple myeloma
Grégoire, Céline ULg; GUIOT, Julien ULg; Vertenoeil, Gaëlle ULg et al

in Acta Clinica Belgica (2016)

Objective and Importance: Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have ... [more ▼]

Objective and Importance: Yellow nail syndrome (YNS) is a rare disorder of unknown aetiology characterized by the triad of yellow nails, lymphoedema and respiratory manifestations. About 200 cases have been reported, but a lot of patients probably elude proper diagnosis because of both variability of symptoms and ignorance of this syndrome by many physicians. The pathogenesis remains unclear, and could involve functional lymphatic abnormalities, microvasculopathy or lymphocyte deficiency, but none of these hypotheses seems fully satisfactory. Clinical Presentation: We report for the first time two cases of YNS associated with multiple myeloma relapsing after non-myeloablative haematopoietic cell transplantation (HCT). In these two cases, onset or worsening of YNS symptoms followed graft-versus-host disease (GvHD) manifestations. Intervention: Corticosteroids given to treat GvHD also improved YNS manifestations. Conclusion: YNS after HCT might be a microvascular manifestation of endothelial GvHD and corticosteroids might be an effective treatment. [less ▲]

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See detailRevealing the formation of copper nanoparticles from a homogeneous solid precursor by electron microscopy
Van den Berg, Roy; Elkjaer, Christian; Gommes, Cédric ULg et al

in Journal of the American Chemical Society (2016)

The understanding of processes leading to the formation of nanometer-sized particles is important for tailoring of their size, shape and location. The growth mechanisms and kinetics of nanoparticles from ... [more ▼]

The understanding of processes leading to the formation of nanometer-sized particles is important for tailoring of their size, shape and location. The growth mechanisms and kinetics of nanoparticles from solid precursors are, however, often poorly described. Here we employ transmission electron microscopy (TEM) to examine the formation of copper nanoparticles on a silica support during the reduction by H2 of homogeneous copper phyllosilicate plates, as a prototype precursor for a co-precipitated catalyst. Specifically, time-lapsed TEM image series acquired of the material during the reduction provide a direct visualization of the growth dynamics of an ensemble of individual nanoparticles and enable a quantitative evaluation of the nucleation and growth of the nanoparticles. This quantitative information is compared with kinetic models and found to be best described by a nucleation-and-growth scenario involving autocatalytic reduction of the copper phyllosilicate followed by diffusion-limited or reaction-limited growth of the copper nanoparticles. The plate-like structure of the precursor restricted the diffusion of copper and the autocatalytic reduction limited the probability for secondary nucleation. The combination of a uniform size of precursor particles and the autocatalytic reduction thus offers means to synthesize nanoparticles with well-defined sizes in large amounts. In this way, in situ observations made by electron microscopy provide mechanistic and kinetic insights into the formation of metallic nanoparticles, essential for the rational design of nanomaterials. [less ▲]

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See detailPrognostic relevance of epilepsy at presentation in glioblastoma patients.
Berendsen, Sharon; Varkila, Meri; Kroonen, Jerome et al

in Neuro-oncology (2016)

BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due to early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship ... [more ▼]

BACKGROUND: Epileptogenic glioblastomas are thought to convey a favorable prognosis, either due to early diagnosis or potential antitumor effects of antiepileptic drugs. We investigated the relationship between survival and epilepsy at presentation, early diagnosis, and antiepileptic drug therapy in glioblastoma patients. METHODS: Multivariable Cox regression was applied to survival data of 647 consecutive patients diagnosed with de novo glioblastoma between 2005 and 2013 in order to investigate the association between epilepsy and survival in glioblastoma patients. In addition, we quantified the association between survival and valproic acid (VPA) treatment. RESULTS: Epilepsy correlated positively with survival (HR: 0.75 (95% CI: 0.61-0.92), P < .01). This effect is independent of age, sex, performance status, type of surgery, adjuvant therapy, tumor location, and tumor volume, suggesting that this positive correlation cannot be attributed solely to early diagnosis. For patients who presented with epilepsy, the use of the antiepileptic drug VPA did not associate with survival when compared with patients who did not receive VPA treatment. CONCLUSION: Epilepsy is an independent prognostic factor for longer survival in glioblastoma patients. This prognostic effect is not solely explained by early diagnosis, and survival is not associated with VPA treatment. [less ▲]

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See detailSolidarity economy and its anarchist grammar
Frère, Bruno ULg

in Sociology and anthropology (2016), 5(24),

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local ... [more ▼]

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local Exange Trading Systems, proximity services, organic community supported agriculture and fairtrade distributions. Because they try to answer to the Aristotelian theoretical question “what can we do to live harmoniously together?”, these solidarity initiatives are deeply political in the philosophical sense of the term. They galvanize civic commitment at the “micro” level. But today, an important question arises regarding the kind of formal political institution that would speak in the name of all these initiatives. In France, some intellectuals who have an interest in these solidarity initiatives see them as new economic models with the potential to solve the current financial crisis, and they are eager for academic specialists and leaders of the movement to achieve some kind of consensus about the kind of concrete political identity such initiatives may be expected to generate. However this paper studies their way of establishing a basis for moving from micro level initiatives to substantial “macro” polity unity. Using the insights of french pragmatic sociology, and particularly the notion of grammar of justification, it aims to understand what the obstacles to this aim being realised are. [less ▲]

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See detailExploring the bacterial diversity of Belgian steak tartare using metagenetics and qPCR analysis
Delhalle, Laurent ULg; Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg et al

in Journal of Food Protection (2016), 79(2), 200-229

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to ... [more ▼]

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to bacterial spoilage. The objective of this study was to explore the bacterial flora diversity in steak tartare in Belgium according to the source and to determine which bacteria are able to grow during the shelf life. A total of 58 samples from butchers’ shops, restaurants, sandwich shops and supermarkets were collected. These samples were analyzed using 16S rDNA metagenetics, a classical microbiological technique, and quantitative real-time PCR (qPCR) targeting the Lactobacillus genus. Samples were analyzed at the beginning and at the end of their shelf life, except for those from restaurants and sandwich shops analyzed only at the purchase date. Metagenetic analysis identified up to 180 bacterial species and 90 genera in some samples. But only seven bacterial species were predominant in the samples, depending on the source: Brochothrix thermosphacta, Lactobacillus algidus, Lactococcus piscium, Leuconostoc gelidum, Photobacterium kishitani, Pseudomonas spp. and Xanthomonas oryzae. With this work, an alternative method is proposed to evaluate the total flora in food samples based on the number of reads from metagenetic analysis and the results of qPCR. The degree of underestimation of aerobic plate counts (APCs) at 30°C estimated with the classical microbiology method was demonstrated in comparison with the proposed culture independent method. Compared to culture-based methods, metagenetic analysis combined with qPCR targeting Lactobacillus provides valuable information for characterizing the bacterial flora of raw meat. [less ▲]

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See detailTargeted control of the saddle gall midge, Haplodiplosis marginata (von Roser) (Diptera: Cecidomyiidae), and the benefits of good control of this pest to winter wheat yield
Censier, Florence ULg; Chavalle, Sandrine ULg; San Martin y Gomez, Gilles et al

in Pest Management Science (2016)

BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe ... [more ▼]

BACKGROUND: Since 2010, there has been a resurgence of the saddle gall midge, Haplodiplosis marginata (von Roser), in Belgium and several other European countries, with this pest sometimes causing severe damage in cereals. In 2012 and 2013, field trials were conducted in heavily infested fields to assess its impact on winter wheat crops and to determine efficient ways of dealing with severe infestations. RESULTS: Crop exposure to H. marginata varied with the different protection methods tried. These methods included one to four successive applications of lambda-cyhalothrin. Yield losses were significant, reaching 6% in 2012 and as high as 15% in 2013, and these losses were linearly related to the number of galls on stems. CONCLUSION: The trials showed that insecticide applications needed to be synchronized with H. marginata flight peaks and to target the egg hatching period. They also revealed that insecticides applied to coincide with the first flight could, in humid conditions, also reach the larvae close to the soil surface, prior to their pupation. [less ▲]

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See detailSearching for consensus among physicians involved in the management of sick-listed workers in the Belgian health care sector: a qualitative study among practitioners and stakeholders
Vanmeerbeek, Marc ULg; Govers, Patrick ULg; Schippers, Nathalie ULg et al

in BMC Public Health (2016), 16

Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among ... [more ▼]

Background In Belgium, the management of sick leave involves general practitioners (GPs), occupational health physicians (OPs) and social insurance physicians (SIPs). A dysfunctional relationship among these physicians can impede a patient’s ability to return to work. The objective of this study was to identify ways to improve these physicians’ mutual collaboration. Methods Two consensus techniques were successively performed among the three professional groups. Eight nominal groups (NGs) gathered 74 field practitioners, and a two-round Delphi process involved 32 stakeholders. Results From the results, it appears that two areas (reciprocal knowledge and evolution of the legal and regulatory framework) are objects of consensus among the three medical group that were surveyed. Information transfer, particularly electronic transfer, was stressed as an important way to improve. The consensual proposals regarding interdisciplinary collaboration indicate specific and practical changes to be implemented when professionals are managing workers who are on sick leave. The collaboration process appeared to be currently more problematic, but the participants correctly identified the need for common training. Conclusions The three physician groups all agree regarding several inter-physician collaboration proposals. The study also revealed a latent conflict situation among the analysed professionals that can arise from a lack of mutual recognition. Practical changes or improvements must be included in an extended framework that involves the different determinants of interdisciplinary collaboration that are shown by theoretical models. Collaboration is a product of the actions and behaviours of various partners, which requires reciprocal knowledge and trust; collaboration also implies political and economic structures that are led by public health authorities. [less ▲]

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See detailFe3+/Iron Oxide/SiO2 Xerogel Catalysts for p-nitrophenol Degradation by Photo-Fenton Effects: Influence of Thermal Treatment on Catalysts Texture
Mahy, Julien ULg; Tasseroul, Ludivine ULg; Herlitscke, Marcus et al

in Materials Today: Proceedings (2016), 3(2), 464-469

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ... [more ▼]

Three iron xerogel catalysts were synthesized by hydrolysis and condensation of tetraethoxysilane (TEOS) and 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) which is able to form a chelate with iron ions. Four thermal treatments were applied to catalysts: drying, drying-autoclaving, calcination and calcination-autoclaving. Textural characterizations show that the specific surface area is increased by calcination while materials microporosity completely collapse when using autoclaving. Based on Mössbauer spectroscopy and magnetometry measurements, only Fe3+ species were observed in xerogel catalysts. The photo-Fenton effect of these catalysts was evaluated on the degradation of p-nitrophenol in aqueous media. In the presence of H2O2, results show that this effect reachs 99% of degradation after 24 h. Mössbauer and catalytic tests are presented in another paper. [less ▲]

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See detailTests of a new drowsiness characterization and monitoring system based on ocular parameters
François, Clémentine ULg; Hoyoux, Thomas ULg; Langohr, Thomas ULg et al

in International Journal of Environmental Research and Public Health (2016)

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See detailBi-objective Road and Pipe Network Design for Crude Oil Transport in the Sfax Region in Tunisia
Belaid, Emna ULg; Limbourg, Sabine ULg; Mostert, Martine ULg et al

in Procedia Engineering (2016), 142

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the ... [more ▼]

In this paper, we examine a bi-objective road and pipe network design for crude oil transport in the Sfax region in Tunisia. In particular, we search for the minimum spanning trees (MST) that connect the different oil fields with the port of La Skhirra. In the determination of the minimum spanning trees, two objectives are taken into account, i.e. accident risk and construction costs. By using an improved ɛ-constraint resolution technique, the Pareto optimal combinations of risk and cost are found. Results indicate that the network solutions by pipe outperform the solutions by road. When the minimum spanning trees for the two extremes on the Pareto curves, i.e. the cost minimum and risk minimum, are compared, one could note considerable differences in the links that form the MST. This implies that policy makers have an important role in deliberating between costs and risks. [less ▲]

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See detailThe thyroid gland and thyroid hormones in sheepshead minnow (Cyprinodon variegatus) during early development and metamorphosis
Schnitzler, Joseph ULg; Klaren, Peter; Mariavelle, Emeline ULg et al

in Fish Physiology and Biochemistry (2016), 42(2), 607-616

The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However ... [more ▼]

The sheepshead minnow is widely used in ecotoxicological studies that only recently have begun to focus on disruption of the thyroid axis by xenobiotics and endocrine disrupting compounds. However, reference levels of the thyroid prohormone thyroxine (T4) and biologically active hormone 3,5,30-triiodothyronine (T3) and their developmental patterns are unknown. This study set out to describe the ontogeny and morphology of the thyroid gland in sheepshead minnow, and to correlate these with whole-body concentrations of thyroid hormones during early development and metamorphosis. Eggs were collected by natural spawning in our laboratory. T4 and T3 were extracted from embryos, larvae and juveniles and an enzyme-linked immunoassay was used to measure whole-body hormone levels. Length and body mass, hatching success, gross morphology, thyroid hormone levels and histology were measured. The onset of metamorphosis at 12-day post-hatching coincided with surges in whole-body T4 and T3 concentrations. Thyroid follicles were first observed in pre-metamorphic larvae at hatching and were detected exclusively in the subpharyngeal region, surrounding the ventral aorta. Follicle size and thyrocyte epithelial cell heights varied during development, indicating fluctuations in thyroid hormone synthesis activity. The increase in the whole-body T3/T4 ratio was indicative of an increase in outer ring deiodination activity. This study establishes a baseline for thyroid hormones in sheepshead minnows, which will be useful for the understanding of thyroid hormone functions and in future studies of thyroid toxicants in this species. [less ▲]

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See detailImproving Farmers’ Profitability, Soil and Water Conservation through an Adapted Tillage Technique: Experiences from the Cultivation of Potatoes in Bamiléké’s Hills, Cameroon
Djoukeng, Henri Grisseur ULg; Brostaux, Yves ULg; Tankou, Christopher Mubeteneh et al

in International Journal of Agriculture Innovations and Research (2016), 4(4), 708-716

On farms situated on slopes, such as those in the Western Highlands of Cameroon, the implementation of soil and water conservation techniques remains a major concern. The land preparation methods commonly ... [more ▼]

On farms situated on slopes, such as those in the Western Highlands of Cameroon, the implementation of soil and water conservation techniques remains a major concern. The land preparation methods commonly practiced in the Western Highlands agro-ecological zone of Cameroon are ridging along the steepest slopes (RASS) and the flatbed (FB). Field observations showed FB and RASS promote erosion by runoff, thereby compromising some agriculture functions (environmental function, production function and even social function). In order to ensure soil stability and maintain good water quality for rivers, a new land preparation method, tied ridging (TR), was tested. Erosion by runoff tests were conducted with four blocks of three plots on each of the most commonly exploited slopes, namely 11% and 29% gradient. With the main crop in the area (potato, Solanum tuberosum L.), the performance of RASS, FB, and TR were compared during crop years 2013 and 2014. The water runoff and sediments were collected per plot and per block after every rainfall. The results showed a significant difference between the FB or RASS and TR in terms of soil loss (Fmin(2, 2) = 322.7, p = 0.003), yields (F(2, 2) = 287.7, p = 0.003), and runoff water (Fmin(2, 12) = 2.4x106, p < 0.001). The TR technique generated a 7% increase in seedlings density, a 41% increase in the workforce, and an 81% and 100% increase in yields compared to FB in 11% and 29% slopes, respectively. The TR increased farmer’s profitability by 686 US$.ha-1 and 1420 US$.ha-1 over RASS in 11% and 29% slopes, respectively. The TR showed undeniable advantages: for the producer, the stress of additional work was offset by the gain in yields while creating additional job opportunities and improving the conservation of soil and water. Although the technique has several advantages, the provision of financial means for its implementation could be a negative point. Twelve farmers were involved in the experiment. The test results convinced the participants and other curious farmers who adopted the technology during the second experiment. [less ▲]

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See detailA quadratic contact element passing the patch test
Nguyen, Duc-Tué; Rauchs, Gast; Ponthot, Jean-Philippe ULg

in Key Engineering Materials [=KEM] (2016), 681

For the two dimensional contact modeling, the standard node-to-segment quadratic contact elements are known to exhibit oscillations of the contact pressure. This situation is particularly critical when ... [more ▼]

For the two dimensional contact modeling, the standard node-to-segment quadratic contact elements are known to exhibit oscillations of the contact pressure. This situation is particularly critical when using the penalty method with a high penalty parameter because the amplitude of the oscillations increase with increasing penalty parameter. The aim of this article is to present a method for removing the oscillations of contact pressure observed while using quadratic contact element. For this purpose, the nodal forces at the slave and at the master nodes need to be evaluated appropriately. One possibility is to develop a suitable procedure for computing the nodal forces. In that sake, we selected the approach first proposed in [35] in an appropriate manner. After presenting the improved quadratic contact element, some numerical examples are illustrated in this paper to compare the standard quadratic node-to-segment element with the proposed element. The examples show that the proposed element can strongly reduce the oscillating contact pressure for both plane and curved contact surfaces. [less ▲]

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See detailL’utilisation de l’hydrolyse enzymatique pour la production de nanocellulose dans une stratégie de bioraffinage forestier intégré
Bombeck, Pierre-Louis ULg; Hebert, Jacques ULg; Richel, Aurore ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(1), 94-103

Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this ... [more ▼]

Introduction. In a world that seeks to break free from petrochemicals, the concept of forest biomass biorefinery is increasingly being studied as a way to maximize the value of the components of this biomass. Due to the high added value expected when transforming cellulose fibers into nanocellulose, this technology is highly attractive to the pulp and paper industrial world. Literature. The concept of integrated forest biorefinery is to adapt existing pulp mills so as to maximize the value of the co-products. Through the use of various methods, two types of nanocellulose may be obtained from the cellulose in the pulp. Due to its production of valuable byproducts, enzymatic hydrolysis is an interesting method to use for this purpose, but it must be combined with mechanical post-treatments. The production of nanocellulose from chemical pulp takes place in the final step of pulp production, and could be implemented without modifying the existing mills. The economic viability of this mode of production and the potential market size are the subject of recent studies that appear encouraging. Conclusions. Nanocellulose is a promising biomaterial whose field of application continues to grow. Cellulose in wood pulp can be used as a raw material for the production of nanocellulose using enzymatic pre-treatments that generate valuable co-products. This process can be integrated into a conventional chemical pulp mill and constitutes a broadening of the products available to the pulp and paper industry. [less ▲]

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See detailUne présentation rare de craniosténose associée à un crâne lacunaire
Vaessen, françois; Thimmesch, Mathieu; BORN, Jacques et al

in Revue Médicale de Liège (2016), 71(3), 120-123

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its ... [more ▼]

A rare case of lacunar skull deformity associated with craniosynostosis Summary : The lacunar skull is a radiologic description characterised by the presence of lacunae in the cranial vault. Its physiopathology remains up to now poorly understood; it is mostly associated with neural tube defects. The association of a lacunar skull with a craniosynostosis has rarely been described in the literature. The case of a 9-month-old patient presenting a multisutural craniosynostosis with a lacunar skull is reported in this article. The surgical treatment allowed to remodel the skull and to hope for a spontaneous regression of the lacunae. [less ▲]

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See detailEACVI appropriateness criteria for the use of cardiovascular imaging in heart failure derived from European National Imaging Societies voting.
Garbi, Madalina; Edvardsen, Thor; Bax, Jeroen et al

in European heart journal cardiovascular Imaging (2016)

This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The ... [more ▼]

This paper presents the first European appropriateness criteria for the use of cardiovascular imaging in heart failure, derived from voting of the European National Imaging Societies representatives. The paper describes the development process and discusses the results. [less ▲]

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See detailTrophic ecology of the seagrass-inhabiting footballer demoiselle Chrysiptera annulata (Peters, 1855); comparison with three other reef-associated damselfishes
Lepoint, Gilles ULg; Michel, Loïc ULg; Parmentier, Eric ULg et al

in Belgian Journal of Zoology (2016), 146(1), 21-32

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming ... [more ▼]

Many damselfishes (Pomacentridae) are herbivorous or omnivorous with an important contribution of different kinds of algae in their diet. They display different levels of territoriality and farming behavior, from almost non territorial to monoculture farmers. In addition, few species inhabit seagrass meadows but, presently, none can be considered as seagrass-eating specialists. The footballer demoiselle, Chrysiptera annulata, is found in the seagrass meadows on the reef flat of the Great Reef of Toliara (Madagascar, Mozambique Channel). Regarding this unusual habitat for pomacentrid, this study aimed to answer 3 questions: 1) What is the diet of C. annulata? 2) Do the resources supporting this diet include seagrass? 3) Does its trophic niche overlap those of other sympatric damselfishes (Pomacentrus trilineatus, Chrysiptera unimaculata and Plectroglyphidodon lacrymatus) living in close association with macrophytes or eating algae? Stomach content examination and stable isotope analysis showed that the footballer demoiselle is not a seagrass consumer but is an omnivorous/herbivorous species heavily relying on algal resources and small invertebrates. SIAR, a stable isotope mixing model, indicated it assimilated large amount of turf algae and various benthic or planktonic invertebrates in lower proportions. SIBER metrics pointed out that isotopic niche of the footballer demoiselle partly overlaps the one of its congeneric C. unimaculata, but not those of P. trilineatus and P. lacrymatus. Trophic strategies of C. annulata differed both from farming species such as P. lacrymatus or from less territorial herbivores such as P. trilineatus. Its seagrass meadow habitat on the Great Reef of Toliara allow the conquest of an unusual habitat for damselfishes and could limit competition with C. unimaculata, a species displaying the same territorial behavior and the same isotopic niche but living on the reef itself. [less ▲]

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See detailScreening for GPR101 defects in pediatric pituitary corticotropinomas.
Trivellin, Giampaolo; Correa, Ricardo R.; Batsis, Maria et al

in Endocrine-related cancer (2016)

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been ... [more ▼]

Cushing disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as MEN1, CDKIs, AIP, and USP8 have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. We investigated the orphan G protein-coupled receptor GPR101, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas. We performed GPR101 sequencing, expression analyses by RT-qPCR and immunostaining, and functional studies (cell proliferation, pituitary hormones secretion, and cAMP measurement) in a series of patients with sporadic CD secondary to ACTH-secreting adenomas in whom we had peripheral and tumor DNA (N=36). No increased GPR101 expression was observed in tumors compared to normal pituitary (NP) tissues, nor did we find a correlation between GPR101 and ACTH expression levels. Sequence analysis revealed a very rare germline heterozygous GPR101 variant (p.G31S) in one patient with CD. Overexpression of the p.G31S variant did not lead to increased growth and proliferation, although modest effects on cAMP signaling were seen. GPR101 is not overexpressed in ACTH-secreting tumors compared to NPs. A rare germline GPR101 variant was found in one patient with CD but in vitro studies did not support a consistent pathogenic effect. GPR101 is unlikely to be involved in the pathogenesis of CD. [less ▲]

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See detailInformation behaviour of French-speaking speech–language therapists in Belgium: results of a questionnaire survey
Durieux, Nancy ULg; Pasleau, Françoise ULg; Piazza, Aurélie ULg et al

in Health Information and Libraries Journal (2016), 33

BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study ... [more ▼]

BACKGROUND: Speech–language therapists (SLTs) are encouraged to implement evidence-based practice (EBP). Nevertheless, EBP use by practitioners can be questioned. OBJECTIVES: The objective of this study was to explore Belgian French-speaking SLTs’ information behaviour and their awareness of EBP. The collected data allow one to determine how far they have embraced this approach. METHODS: The two Belgian French-speaking SLT professional associations promoted an online questionnaire survey by email. Additionally, clinical supervisors of students were asked to participate. In March 2012, 2068 emails were sent. RESULTS: The participation rate was at least 20% (n = 415). The reported information needs mainly concerned treatment or diagnosis. Most of the time, to attempt to fulfil their information needs, SLTs relied on their own resources (personal experience and libraries) and on colleagues in the workplace. When they searched on the Internet, they preferred to use a general search engine rather than a specialised bibliographic database. Barriers to obtaining scientific information are highlighted. Only 12% of the respondents had already heard about EBP. CONCLUSION: This study provides the first overview of the information behaviour of SLTs working in the French community of Belgium. Several recommendations are suggested for SLTs and librarians. [less ▲]

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See detailDefining multiplication in some additive expansions of polynomial rings
Point, Françoise; Rigo, Michel ULg; Waxweiler, Laurent

in Communications in Algebra (2016), 44

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this ... [more ▼]

Adapting a result of R. Villemaire on expansions of Presburger arithmetic, we show how to define multiplication in some expansions of the additive reduct of certain Euclidean rings. In particular, this applies to polynomial rings over a finite field. [less ▲]

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See detailCorrelation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness
Soddu, Andrea ULg; Gomez, Francisco; Heine, Lizette ULg et al

in Brain and Behavior (2016)

Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made ... [more ▼]

Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness. Objective: We assessed the possi- bility of creating functional MRI activity maps, which could estimate the rela- tive levels of activity in FDG-PET cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to FDG-PET. It also overcomes the problem of recogniz- ing individual networks of independent component selection in functional mag- netic resonance imaging (fMRI) resting state analysis. Methods: We extracted resting state fMRI functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neu- ronality of components a classification based on support vector machine (SVM) was used. We compared the generated maps with the FDG-PET maps in 16 healthy controls, 11 vegetative state/unresponsive wakefulness syndrome patients and four locked-in patients. Results: The results show a significant similarity with q = 0.75  0.05 for healthy controls and q = 0.58  0.09 for vegetative state/unresponsive wakefulness syndrome patients between the FDG- PET and the fMRI based maps. FDG-PET, fMRI neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked-in syndrome patients produced also consistent maps with healthy controls. Conclusions: The constructed resting state fMRI functional connectivity map points toward the possibility for fMRI resting state to estimate relative levels of activity in a metabolic map. [less ▲]

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See detailFully automated radiosynthesis of N1-[18F]fluoroethyl-tryptophan and study of its biological activity as a new potential substrate for indoleamine 2,3-dioxygenase PET imaging
Henrottin, Jean ULg; Lemaire, Christian ULg; Egrise, Dominique et al

in Nuclear Medicine & Biology (2016)

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor ... [more ▼]

Introduction: Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial step in the catabolism of L-tryptophan along the kynurenine pathway and exerts immunosuppressive properties in inflammatory and tumor tissues by blocking locally T-lymphocyte proliferation. Recently, 1-(2-[19F]fluoroethyl)-DL-tryptophan (1-[19F]FE-DL-Trp) was reported as a good and specific substrate of this enzyme. Herein, the radiosynthesis of its radioactive isotopomer (1-[18F]FE-DL-Trp, DL-[18F]5) is presented along with in vitro enzymatic and cellular uptake studies. Methods: The one-pot n.c.a. radiosynthesis of this novel potential PET imaging tracer, including HPLC purification and formulation, has been fully automated on a FASTlabTM synthesizer. Chiral separation of both isomers and their formulation were implemented on a second cassette. In vitro enzymatic and cellular uptake studies were then conducted with the D-, L- and DL-radiotracers. Results: The radiolabeling of the tosylate precursor was performed in DMF (in 5 min; RCY: 57% (d.c.), n=3). After hydrolysis, HPLC purification and formulation, DL-[18F]5 was obtained with a global radiochemical yield of 18±3% (not decay corrected, n=7, in 80 min) and a specific activity of 600±180 GBq/µmol (n=5). The subsequent separation of L- and D-enantiomers was performed by chiral HPLC and both were obtained after formulation with a RCY (d.c.) of 6.1% and 5.8%, respectively. In vitro enzymatic assays reveal that L-[18F]5 is a better substrate than D-[18F]5 for human IDO. In vitro cellular assays show an IDO-specific uptake of the racemate varying from 30% to 50% of that of L-[18F]5, and a negligible uptake of D-[18F]5. Conclusion: In vitro studies show that L-[18F]5 is a good and specific substrate of hIDO, while presenting a very low efflux. These results confirm that L-[18F]5 could be a very useful PET radiotracer for IDO expressing cells in cancer imaging. [less ▲]

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See detailInterrelations de la criminologie et du droit autour de la délinquance juvénile : Je t’aime moi non plus
Mathys, Cécile ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 1

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See detailResponse to novely and cocaine stimulant effects: lack of stability across environments in female Swiss mice
Nyssen, Laura ULg; Brabant, Christian ULg; Didone, Vincent ULg et al

in Psychopharmacology (2016), 233

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model ... [more ▼]

Rationale: In humans, novelty/sensation seeking is seen as a personality trait with a positive relationship with addiction vulnerability. In animal studies, one of the standard proce-dures to model novelty seeking is the "response to novelty," i.e., the levels of locomotor activity in a new environment. In rodents, a positive correlation was demonstrated between the response to novelty and several effects of drugs, especially the locomotor stimulant effects of cocaine. Objectives: The present study was designed to test in mice whether the response to novelty is stable across environments and whether its relationship with the stimulant effects of cocaine is altered by environmental changes. Experiment 1 assessed the responses to novelty of the same mice in two different novel environments. Experiment 2 tested the correlation between response to novelty and acute stimulant effects of cocaine recorded in two distinct environments. Results: The results show a weak correlation only during the first 5 min of the session between the responses to novelty measured in two distinct environments. Experiment 2 demonstrates that novelty responses and stimulant effects of cocaine are positively correlated only when both behavioral responses are measured in the same environment. In contrast, the relationship between response to novelty and acute stimulant effects of cocaine is completely lost when the behavioral responses are recorded in two different environments. Conclusions: The present results question the usual interpretation of the correlation between the response to novelty and the stimulant effects of cocaine as reflecting a relationship between two underlying individual stable characteristics. [less ▲]

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See detailÉtude des potentialités des systèmes d’application contrôlée des gouttes (CDA) pour les traitements phytosanitaires en céréaliculture (synthèse bibliographique)
Ouled Taleb Salah, Sofiene ULg; De Cock, Nicolas ULg; Massinon, Mathieu ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016)

Introduction. L’application contrôlée des gouttes (CDA) présente le double avantage de réduire à la fois l’étendue de la distribution des tailles des gouttes et le volume appliqué par rapport aux buses ... [more ▼]

Introduction. L’application contrôlée des gouttes (CDA) présente le double avantage de réduire à la fois l’étendue de la distribution des tailles des gouttes et le volume appliqué par rapport aux buses hydrauliques conventionnelles. Littérature. Cette revue investigue la potentialité de la CDA par rapport aux buses hydrauliques dans le cadre du désherbage précoce des adventices (2-3 feuilles). En termes de rétention, les études reliant les caractéristiques des gouttes (taille, vitesse et direction) et l’architecture, la densité et la mouillabilité du feuillage, en fonction de la formulation de bouillies, ont été abordées. Ces études montrent que des gouttes de 300 μm avec un adjuvant approprié et des jets émis 60° vers l’avant par rapport à la verticale contribuent à l’augmentation de la rétention sur les cibles problématiques à port dressé. L’effet des réductions des volumes d’application pour ces deux techniques est étudié sur base de la moyenne, du coefficient de variation et du taux de couverture des dépôts. Néanmoins, les résultats de ces études ne peuvent être généralisés du fait des différences de réglages opératoires entre les deux techniques d’application. Quant à la dérive, les atomiseurs CDA orientés horizontalement présentent un potentiel de dérive plus important que les buses hydrauliques pour lesquelles le spray est orienté vers le bas. La dérive augmente avec la vitesse du vent et diminue lorsque le diamètre médian volumétrique (DV50) augmente. Conclusions. De nouveaux réglages des atomiseurs de la CDA en termes de DV50 et de direction du jet peuvent répondre aux défis de l’agriculture de précision. Les pistes d’innovations proposées sont d’une part une amélioration de la résistance à l’usure des dents situées en bordure des disques et, d’autre part, une distribution granulométrique plus étroite. [less ▲]

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See detail[18F]FPRGD2 PET/CT imaging of integrin αvβ3 levels in patients with locally advanced rectal carcinoma
WITHOFS, Nadia ULg; Martinive, Philippe ULg; VANDERICK, Jean ULg et al

in European journal of nuclear medicine and molecular imaging (2016)

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal ... [more ▼]

PURPOSE: Our primary objective was to determine if [18F]FPRGD2 PET/CT performed at baseline and/or after chemoradiotherapy (CRT) could predict tumour regression grade (TRG) in locally advanced rectal cancer (LARC). Secondary objectives were to compare baseline [18F]FPRGD2 and [18F]FDG uptake, to evaluate the correlation between posttreatment [18F]FPRGD2 uptake and tumour microvessel density (MVD) and to determine if [18F]FPRGD2 and FDG PET/CT could predict disease-free survival. METHODS: Baseline [18F]FPRGD2 and FDG PET/CT were performed in 32 consecutive patients (23 men, 9 women; mean age 63 +/- 8 years) with LARC before starting any therapy. A posttreatment [18F]FPRGD2 PET/CT scan was performed in 24 patients after the end of CRT (median interval 7 weeks, range 3 - 15 weeks) and before surgery (median interval 4 days, range 1 - 15 days). RESULTS: All LARC showed uptake of both [18F]FPRGD2 (SUVmax 5.4 +/- 1.5, range 2.7 - 9) and FDG (SUVmax 16.5 +/- 8, range 7.1 - 36.5). There was a moderate positive correlation between [18F]FPRGD2 and FDG SUVmax (Pearson's r = 0.49, p = 0.0026). There was a moderate negative correlation between baseline [18F]FPRGD2 SUVmax and the TRG (Spearman's r = -0.37, p = 0.037), and a [18F]FPRGD2 SUVmax of >5.6 identified all patients with a complete response (TRG 0; AUC 0.84, 95 % CI 0.68 - 1, p = 0.029). In the 24 patients who underwent a posttreatment [18F]FPRGD2 PET/CT scan the response index, calculated as [(SUVmax1 - SUVmax2)/SUVmax1] x 100 %, was not associated with TRG. Post-treatment [18F]FPRGD2 uptake was not correlated with tumour MVD. Neither [18F]FPRGD2 nor FDG uptake predicted disease-free survival. CONCLUSION: Baseline [18F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use. [less ▲]

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See detailLa cognitivo-linguistique : pour une tentative de rapprochement de la clinique et de l'actuariel
Courtain, Audrey ULg; Glowacz, Fabienne ULg

in Revue Internationale de Criminologie et de Police Technique et Scientifique [= RICPTS] (2016), 1

Anchored in the actuarial field, risk assessment is a tool clinicians are more and more likely to use (because they can or have to) among delinquents. But, due to epistemological differences, an important ... [more ▼]

Anchored in the actuarial field, risk assessment is a tool clinicians are more and more likely to use (because they can or have to) among delinquents. But, due to epistemological differences, an important debate has been occurring between the clinical evaluation and the actuarial one since the fifties. This paper suggests a media between those perspectives through cognitive linguistics: it allows a complementary articulation, while insisting on what is at stake for both clinical and actuarial developments. Linking language and cognitions, the paper introduces a reflexion that may be useful to actuarial assessment and clinical support, and may facilitate rapprochement between the latter. In this case, our linguistic approach focusses on different matters targeted by actuarial tools and whose clinical understanding may be deepened by studying the link between language and cognition; this clinical understanding bringing singularity to risk assessment. [less ▲]

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See detailPassive acoustic recording of Ophidion rochei calling activity in Calvi Bay (France)
Kever, Loïc ULg; Lejeune, Pierre; Michel, Loïc ULg et al

in Marine Ecology (2016)

Passive acoustic recording (PAR) systems are non-invasive and allow researchers to collect data on large spatial and temporal scales. Since fish sounds are species-specific and repetitive, PAR can provide ... [more ▼]

Passive acoustic recording (PAR) systems are non-invasive and allow researchers to collect data on large spatial and temporal scales. Since fish sounds are species-specific and repetitive, PAR can provide a large amount of data about spatio-temporal variation in fish distribution and behaviors. Ophidion rochei is a sand-dwelling species from Mediterranean and Black Sea meaning the behavior of this discreet nocturnal fish cannot be observed in the field. Fortunately, male O. rochei produce long multiple-pulsed calls that are easy to identify. The aim of this study was to determine that male calls are linked to reproduction behaviors. If so, PAR would allow a fine description of the seasonal and daily cycles in O. rochei reproduction. A hydrophone was deployed from 18 July 2011 to 21 June 2012 and from 7 June 2013 to 2 July 2013 on a sandy area (42.5801° N, 8.7285° E) in front of the STARESO research station (NW Corsica). Male sounds were obtained only at night from late spring to early fall. The annual sound production period corresponds to the reproductive season of O. rochei. Sound production followed diel cycles: it was sustained for the entire night at the beginning of the sound production season but limited to shorter periods in the evening during the second half of the season. These differences in daily and seasonal sound production tempo can be used in future recordings to make inter-annual comparisons and estimate the physiological state of the fish. [less ▲]

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See detailCompte-rendu de Andrea Nicolotti, Le Saint Suaire de Besançon et le chevalier Othon de la Roche
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailStructured carbons as supports for hydrogenation hybrid catalysts prepared by the immobilization of a Rh diamine complex
Gheorghiu, Cristina; Garcia-Bordeje, Enrique; Job, Nathalie ULg et al

in Chemical Engineering Journal (2016), 291

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See detailThe role of personal goals in autonoetic experience when imagining future events
Lehner, Edith; D'Argembeau, Arnaud ULg

in Consciousness & Cognition (2016), 42

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See detailVegetation classification and biogeography of European floodplain forests and alder carrs
Douda, Jan; Boublik, Karel; Slezak, Michal et al

in Applied Vegetation Science (2016)

Aim: Formalized classifications synthesizing vegetation data at the continental scale are being attempted only now, although they are of key importance for nature conservation planning. Therefore, we aim ... [more ▼]

Aim: Formalized classifications synthesizing vegetation data at the continental scale are being attempted only now, although they are of key importance for nature conservation planning. Therefore, we aim to provide a vegetation classification and to describe the main iogeographical patterns of floodplain forests and alder carrs in Europe. Location: Europe. Methods: A database of more than 40 000 vegetation plots of floodplain forests and alder carrs across Europe was compiled. After geographic stratification, 16 392 plots were available for classification, which was performed using the supervised method Cocktail. We also searched for new associations using semi-supervised K-means classification. The main biogeographic patterns and climate-related gradients in species composition were determined using detrended correspondence analysis and cluster analysis. Results: Thirty associations of floodplain forests and alder carrs were distinguished, which belong to five alliances. The Alnion incanae includes riparian, seepage and hardwood floodplain forests in the nemoral and hemiboreal zones (dominated by Alnus glutinosa and Fraxinus excelsior) and in the boreal zone (dominated by A. incana). The Osmundo-Alnion represents oceanic vegetation dominated by Alnus glutinosa, Fraxinus angustifolia and F. excelsior distributedmostly on the Iberian Peninsula and composed of species with Atlantic distribution and Iberian endemics. The Populion albae comprises floodplain forests frequently dominated by Fraxinus angustifolia, Populus alba and P. nigra that arewidespread in floodplains of large rivers under summer-dry climates in the Mediterranean region. The Platanion orientalis represents easternMediterranean floodplain forests dominated by Platanus orientalis. The Alnion glutinosae includes forest swamps dominated by Alnus glutinosa distributed mostly in the nemoral and hemiboreal zones. The main biogeographic patterns within European floodplain forests and alder carrs reflect the climatic contrasts between the Mediterranean, nemoral, boreal andmountain regions. Oceanic floodplain forests differ fromthose in the rest of Europe. The hydrological regime appears to be themost important factor influencing species compositionwithin regions. Conclusions: This study is the first applying a formalized classification at the association level for a broad vegetation type at the continental scale. The proposed classification provides the scientific basis for the necessary improvement of the habitat classification systems used in European nature conservation. [less ▲]

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See detailPalindromic sequences generated from marked morphisms
Labbé, Sébastien ULg; Pelantova, Edita

in European Journal of Combinatorics (2016), 51

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See detailL’épandage d’engrais de ferme avant le semis d’une culture intermédiaire (CIPAN) présente-t-il un risque important de lixiviation de nitrate ?
Vandenberghe, Christophe ULg; De Toffoli, Marc; Lambert, Richard et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2),

Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the ... [more ▼]

Description of the subject. The implementation of the Nitrates Directives in the Walloon region (in the south of Belgium) allows the summer spreading of any kind of manure on soils in preparation for the sowing of a catch crop. Objectives. This paper aims to assess whether the spreading of a manure before sowing a catch crop is more risky for groundwater quality than planting a cereal followed by another crop without any action being implemented between the harvesting of the cereal and the sowing (winter or spring) of the next crop. Method. This study is based on measurements of the nitrate nitrogen content of soils, at the beginning of the leaching period, performed on reference parcels and on controlled parcels. Results. Three thousand six hundred soil analyses performed in relation to controlled parcels between 2008 and 2013 showed that the presence of a catch crop (information about the possible application of a manure was not known) led to a nitrate nitrogen content (median) lower (with a very highly significant difference) than in a situation where no action was implemented between the two main crops. For the same period, the analysis of 600 results in reference parcels led to the same conclusion. Moreover, no significant difference was found between the two kinds of manure (“fast action”, such as pig slurry or “low action”, such as bovine manure). Conclusions. After the harvesting of a cereal, the spreading of a manure before sowing a catch crop creates no higher risk for water quality than the succession of a cereal by a crop sowed in the autumn. [less ▲]

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See detailNew data about anatomy, branching, and inferred growth patterns in the Early Devonian plant Armoricaphyton chateaupannense, Montjean-sur-Loire, France
Gerrienne, Philippe ULg; Gensel, PG

in Review of Palaeobotany and Palynology (2016), 224(Part 1), 38-53

This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien ... [more ▼]

This study provides detailed information, based on serial peels, on the anatomy of the primary and secondary xylem, lateral branch formation, and proposed growth pattern of Armoricaphyton Strullu-Derrien et al., an Early Devonian (Pragian) basal euphyllophyte. The centrarch primary xylem strand is circular to oval in cross section and includes P-type tracheids. The pattern of lateral branch departure is described in detail based on serial peels. The secondary xylem, illustrated in transverse, radial and tangential longitudinal sections, includes P-type tracheids with similar pitting in radial and tangential walls. The presence of one-walled spaces interpreted as rays is confirmed. This study also documents the earliest occurrence of secondary xylem at bases of next higher order of branches. A model of growth for this unusual Early Devonian plant is presented, with documented epidogenetic, menetogenetic and possible apoxogenetic phases. The difference in proportion of primary tosecondary xylem is postulated to be a result of this mode of growth. The possible implications of xylem size and organization in the lateral organ in Armoricaphyton relative to the early evolution of the megaphyllous leaf are briefly discussed. [less ▲]

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See detailToxicokinetics of selenium in the slider turtle Trachemys scripta
Dyc, Christelle; Far, Johann ULg; Gandar, Frederic ULg et al

in Ecotoxicology (2016), 25

Selenium (Se) is an essential element that can be harmful for wildlife. However, its toxicity in poikilothermic amniotes, including turtles, remains poorly investigated. The present study aims at ... [more ▼]

Selenium (Se) is an essential element that can be harmful for wildlife. However, its toxicity in poikilothermic amniotes, including turtles, remains poorly investigated. The present study aims at identifying selenium toxicokinetics and toxicity in juvenile slider turtles (age: 7 months), Trachemys scripta, dietary exposed to selenium, as selenomethionine SeMet, for eight weeks. Non-destructive tissues (i.e. carapace, scutes, skin and blood) were further tested for their suitability to predict selenium levels in target tissues (i.e. kidney, liver and muscle) From conservation perspective. 130 juvenile yellow-bellied slider turtles were assigned in three groups of 42 individuals each (i.e. control, SeMet1 and SeMet2). These groups were subjected to a feeding trial including an eight-week supplementation period SP8 and a following four-week elimination period EP4. During the SP8, turtles fed on diet containing 1.1 ± 0.04, 22.1 ± 1.0 and 45.0 ± 2.0 µg.g-1 of selenium (control, SeMet1 and SeMet2, respectively). During the EP4, turtles fed on non-supplemented diet. At different time during the trial, six individuals per group were sacrificed and tissues collected (i.e. carapace, scutes, skin, blood, liver, kidney, muscle) for analyses. During the SP8 (Figure 1), both SeMet1 and SeMet2 turtles efficiently accumulated selenium from a SeMet dietary source. The more selenium was concentrated in the food, the more it was in the turtle body but the less it was removed from their tissues. Moreover, SeMet was found to be the more abundant selenium species in turtles’ tissues. Body condition (i.e. growth in mass and size, feeding behaviour and activity) and survival of the SeMet1 and SeMet2 turtles seemed to be unaffected by the selenium exposure. There were clear evidences that reptilian species are differently affected by and sensitive to selenium exposure but the lack of any adverse effects was quite unexpected. [less ▲]

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See detailExamen de jurisprudence (2010-2013) - Les sociétés commerciales (première partie)
Caprasse, Olivier ULg; Dieux, Xavier; Lambrecht, Philippe

in Revue Critique de Jurisprudence Belge [= RCJB] (2016)

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See detailInvestigational insulin secretagogues for type 2 diabetes.
SCHEEN, André ULg

in Expert opinion on investigational drugs (2016), 25(4), 405-22

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent ... [more ▼]

INTRODUCTION: Insulin secretory defects are a key feature in the pathophysiology of type 2 diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin secretion independent of glucose and cause hypoglycemia. Despite the advantages offered by incretin-based therapies, there is still a medical need for developing new insulin secretagogues for treating T2D. AREA COVERED: This article discusses: the new advances in the field of incretin-based therapies, glucokinase (GK) activators, free fatty acid receptor (FFAR) or G protein-coupled receptor (GPR) agonists (GPR40, GPR119, GPR120), imeglimin and some other insulin secretagogues with diverse mechanisms of action still in preclinical development. EXPERT OPINION: New insulin secretagogues should offer major advantages over sulfonylureas and gliptins. The challenge is to avoid uncontrolled insulin secretion and minimize the risk of hypoglycemia, to protect cells from progressive loss of mass and function for a better durability of glucose control, and to offer a good safety profile. Numerous approaches are in development. However, it is too early to decide whether one new pharmacological class will emerge as a clinically useful insulin secretagogue in the near feature. [less ▲]

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See detailGeneralized Pascal triangle for binomial coefficients of words
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Advances in Applied Mathematics (2016), 80

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word ... [more ▼]

We introduce a generalization of Pascal triangle based on binomial coefficients of finite words. These coefficients count the number of times a word appears as a subsequence of another finite word. Similarly to the Sierpiński gasket that can be built as the limit set, for the Hausdorff distance, of a convergent sequence of normalized compact blocks extracted from Pascal triangle modulo 2, we describe and study the first properties of the subset of [0, 1] × [0, 1] associated with this extended Pascal triangle modulo a prime p. [less ▲]

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See detailExternal Costs as Competitiveness Factors for Freight Transport — A State of the Art
Mostert, Martine ULg; Limbourg, Sabine ULg

in Transport Reviews (2016)

External costs have been a key issue in the last years of transport research. In Europe, this trend is in line with the political willingness to internalize externalities in transport pricing policies ... [more ▼]

External costs have been a key issue in the last years of transport research. In Europe, this trend is in line with the political willingness to internalize externalities in transport pricing policies. This paper has two purposes. It first identifies the recent work achieved in the field of external costs of road and intermodal freight transport, where each paper is assessed in terms of its perspective (academic or project oriented), its objective (prescription, application, projection), the type of externality (air pollution, climate change, noise, accidents, congestion) and the type of cost (marginal, average, total) that is considered. The literature review reveals a gap in the development of generic mathematical functions for external costs of transport. The second objective of the paper is thus to highlight the usefulness of such functions by identifying the main parameters that influence freight transport competitiveness in terms of external costs, and by determining which of these parameters should be incorporated in further research works. [less ▲]

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See detailPermeability evolution and water transfer in the excavation damaged zone of a ventilated gallery
Pardoen, Benoît ULg; Talandier, Jean; Collin, Frédéric ULg

in International Journal of Rock Mechanics & Mining Sciences (2016), 85

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers ... [more ▼]

The fluid transfers occurring around underground galleries are of paramount importance when envisaging the long-term sustainability of underground structures for nuclear waste disposal. These transfers are mainly conditioned by the behaviour of the surrounding material and by its interaction with the gallery air. The hydro-mechanical behaviour of the excavation damaged zone, which develops around galleries due to the drilling process, is thenceforward critical because it is composed of fractures having a significant irreversible impact on flow characteristics and transfer kinetics. Besides, the material interaction with the gallery air may engender water drainage and desaturation. Thus, a gallery air ventilation experiment, preceded by its excavation, is numerically modelled in an unsaturated argillaceous rock to study its influence on hydraulic transfers. The fractures are numerically represented with shear strain localisation bands by means of a microstructure enriched model including a regularisation method. The impact of fracturing on the transport properties is addressed by associating the intrinsic permeability increase with mechanical deformation which is amplified in the strain localisation discontinuities. Such dependence permits us to reproduce a significant permeability increase of several orders of magnitude in the excavation damaged zone, in agreement with available experimental measurements. After the excavation, the hydraulic transfers are studied through the reproduction of a gallery air ventilation experiment that implies drainage and desaturation of the surrounding rock. These transfers depend on liquid water and water vapour exchanges at gallery wall that are introduced through a non-classical boundary condition. The model prediction successfully captures the drainage and desaturation kinetics of undisturbed and damaged rock. [less ▲]

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See detailHow much does the Dallas Pain Questionnaire score have to improve to indicate that patients with chronic low back pain feel better or well?
Marty, M; Courvoisier, D; Foltz, V et al

in European Spine Journal (2016), 25

Purpose: The Dallas Pain Questionnaire (DPQ) assesses the impact of low back pain (LBP) on four components (0–100) of daily life. We estimated the minimal clinically important improvement (MCII) and the ... [more ▼]

Purpose: The Dallas Pain Questionnaire (DPQ) assesses the impact of low back pain (LBP) on four components (0–100) of daily life. We estimated the minimal clinically important improvement (MCII) and the patient acceptable symptom state (PASS) values of DPQ in LBP patients. Methods: 142 patients with LBP lasting for at least 4 weeks completed a battery of questionnaires at baseline and 6 months later. Questions for MCII addressed patientreported response to treatment at 6 months on a five-point Likert scale, while a yes/no question concerning satisfaction with present state was used to determine PASS. MCII wascomputed as the difference in mean DPQ scores between patients reporting treatment as effective vs. patients reporting treatment as not effective, and PASS was computed as the third quartile of the DPQ score among patients who reported being satisfied with their present state. Results: MCII values were 22, 23, 2 and 10 for daily activities, work and leisure, social interest, and anxiety/depression, respectively. PASS values were 29, 23, 20 and 21 for the four components, respectively. The PASS total score threshold of 24 correctly classified 84.1 % of the patients who reported being unsatisfied with their present state, and 74.7 % of patients reported being satisfied. Conclusions: These values give information of paramount importance for clinicians in interpreting change in DPQ values over time. Authors should be encouraged to report the percentage of patients who reach MCII and PASS values in randomized clinical trials and cohort studies to help clinicians to interpret clinical results. [less ▲]

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See detailNeural correlates of event clusters in past and future thoughts: How the brain integrates specific episodes with autobiographical knowledge
Demblon, Julie ULg; Bahri, Mohamed Ali ULg; D'Argembeau, Arnaud ULg

in NeuroImage (2016), 127

When remembering the past or envisioning the future, events often come to mind in organized sequences or stories rather than in isolation from one another. The aim of the present fMRI study was to ... [more ▼]

When remembering the past or envisioning the future, events often come to mind in organized sequences or stories rather than in isolation from one another. The aim of the present fMRI study was to investigate the neural correlates of such event clusters. Participants were asked to consider pairs of specific past or future events: in one condition, the two events were part of the same event cluster (i.e., they were thematically and/or causally related to each other), whereas in another condition the two events only shared a surface feature (i.e., their location); a third condition was also included, in which the two events were unrelated to each other. The results showed that the processing of past and future events that were part of a same cluster was associated with higher activation in the medial prefrontal cortex (PFC), rostrolateral PFC, and left lateral temporal and parietal regions, compared to the two other conditions. Furthermore, functional connectivity analyses revealed an increased coupling between these cortical regions. These findings suggest that largely similar processes are involved in organizing events in clusters for the past and the future. The medial and rostrolateral PFC might play a pivotal role in mediating the integration of specific events with conceptual autobiographical knowledge ‘stored’ in more posterior regions. Through this integrative process, this set of brain regions might contribute to the attribution of an overarching meaning to representations of specific past and future events, by contextualizing them with respect to personal goals and general knowledge about one's life story. [less ▲]

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See detailImpact of climatic factors on the release of E-β-caryophyllene from alginate beads
Daems, Frédéric ULg; Bera, François ULg; Lorge, Stéphanie ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2016), 20(2),

Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little ... [more ▼]

Description of the subject. Alginate beads that release semiochemical compounds are interesting biological control devices used to attract the natural enemies of aphids in infested crops. Little information, however, is available about the impact of climatic factors on the release of semiochemicals from this diffusive system. Objectives. The objective of this scoping study was to investigate the impact of temperature, relative humidity and wind speed, on the release of E-β-caryophyllene from alginate beads. Method. The impact of the three climatic factors on the release of E-β-caryophyllene from alginate beads was evaluated using a Box-Behnken experimental design and a laboratory scale volatile collection system. The influence of relative humidity on bead water content and size, with and without this semiochemical, was also investigated using a gravimetric method and an easy-to-use photographic device, respectively. Results. The results showed that an increase in temperature caused a significant increase in the E-β¬-caryophyllene release rate. Neither relative humidity nor airflow, however, had a significant effect on the release of this semiochemical when relative humidity and wind speed ranged from 33% to 75% and from 6.61 x10-4 m.s-1 to 2.05 x10-2 m.s-1, respectively. The isotherm curves obtained were characteristic of food products and biopolymer materials. The isotherm shapes were not modified by the incorporation of the semiochemical into alginate beads, and showed an important increase in water content when relative humidity values exceeded 85%. Fortunately, this water content increase did not affect bead size, which facilitates the calculation of E-β-caryophyllene release. Conclusion. The present study shows for the first time the impact of the three main climatic factors on the release of E-β-caryophyllene from alginate beads. It allows learning more about how these biological control devices operate in order to optimize future field trials. [less ▲]

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See detailOntogenic variation and effect of collection procedure on leaf biomechanical properties of Mediterranean seagrass Posidonia oceanica (L.) Delile
de los santos, Carmen; Vicencio, Barbara; Lepoint, Gilles ULg et al

in Marine Ecology (2016)

Leaf mechanical traits are important to understand how aquatic plants fracture and deform when subjected to abiotic (currents or waves) or biotic (herbivory attack) mechanical forces. The likely ... [more ▼]

Leaf mechanical traits are important to understand how aquatic plants fracture and deform when subjected to abiotic (currents or waves) or biotic (herbivory attack) mechanical forces. The likely occurrence of variation during leaf onto- geny in these traits may thus have implications for hydrodynamic performance and vulnerability to herbivory damage, and may be associated with changes in morphologic and chemical traits. Seagrasses, marine flowering plants, consist of shoot bundles holding several leaves with different developmental stages, in which outer older leaves protect inner younger leaves. In this study we examined the long-lived seagrass Posidonia oceanica to determine ontogenic variation in mechanical traits across leaf position within a shoot, representing different devel- opmental stages. Moreover, we investigated whether or not the collection proce- dure (classical uprooted shoot versus non-destructive shoot method: cutting the shoot without a portion of rhizome) and time span after collection influence mechanical measurements. Neither collection procedure nor time elapsed within 48 h of collection affected measurements of leaf biomechanical traits when sea- grass shoots were kept moist in dark cool conditions. Ontogenic variation in mechanical traits in P. oceanica leaves over intermediate and adult developmen- tal stages was observed: leaves weakened and lost stiffness with aging, while mid- aged leaves (the longest and thickest ones) were able to withstand higher break- ing forces. In addition, younger leaves had higher nitrogen content and lower fiber content than older leaves. The observed patterns may explain fine-scale within-shoot ecological processes of leaves at different developmental stages, such as leaf shedding and herbivory consumption in P. oceanica. [less ▲]

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See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

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See detailConsumer acceptance of insect-based alternative meat products in Western countries
Caparros Megido, Rudy ULg; Gierts, Chloé; Blecker, Christophe ULg et al

in Food Quality & Preference (2016)

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western ... [more ▼]

During the past few years, entomophagy has been increasing in significance. As insects are generally high in protein, they are principally considered as meat substitutes. Nevertheless, in Western countries, meat substitute consumption is actually very low, principally due to food neophobia and poor sensory qualities in comparison with meat. In insect particular case, food neophobia is clearly high. To reduce insect food neophobia, previous studies suggest to insert invisible insect in food preparation and/or to associate them with known flavors. In this study, a survey on entomophagy perception and hedonic tests were realized to assess the level of sensory-liking of hybrid insect-based burgers (beef, lentils, mealworms and beef, mealworms and lentils). Participants’ overall liking of the four burgers differed between genders and was influenced by burger appearance and taste. Women clearly preferred beef burger appearance, whereas men preferred the appearance of beef and insect-based burgers. Concerning insect-based burger taste, participants (men and women) rated it intermediately, between that of the beef and lentil burger, with a preference for the mealworm and beef burger. Results also showed that people with previous entomophagy experience was limited but that they gave globally higher ratings to all preparations. In conclusion, insect tasting sessions are important to decrease food neophobia, as they encourage people to “take the first step” and become acquainted with entomophagy. Nevertheless, insect integration into Western food culture will involve a transitional phase with minced or powdered insects incorporated into ready-to-eat preparations, as people are not ready to add insects to their diets in “whole form.” [less ▲]

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See detailThe role of diet and exercise and of glucosamine sulfate in the prevention of knee osteoarthritis: Further results from the PRevention of knee Osteoarthritis in Overweight Females (PROOF) study.
Runhaar, J.; DEROISY, Rita ULg; van Middelkoop, M. et al

in Seminars in Arthritis & Rheumatism (2016), 45(4 Suppl), 42-48

Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a ... [more ▼]

Background and objectives: The PRevention of knee Osteoarthritis in Overweight Females(PROOF) study (ISRCTN42823086) described a trend for a decrease in the incidence of kneeo steoarthritis (OA) by a tailored diet and exercise program (DEP)or by oral glucosamine sulfate in women at risk for the disease, using a composite clinical and/or radiological outcome. The aim of this updated post-hoc analysis was to re-assess the results according to more precise techniques and take advantage of the 2 x 2 factorial design. Methods: A total of 407 overweight( BMI > or egal 27kg/m2) women of 50–60 years of age with no diagnosis of knee OA were randomized to: (1) noDEP + placebo(Control, N = 102), (2) DEP + placebo (DEP, N = 101), (3) glucosamine sulfate + no DEP (GS, N = 102), and (4) DEP + glucosamine sulfate (DEP + GS, N = 102) and followed for 2.5 years, with standardized postero-anterior, semiflexed (MTP) view knee radiographs at baseline and end of the study. DEP consisted of a tailored low fat and/or low caloric diet and easy to implement physical activities. Glucosamine was given as oral crystalline glucosamine sulfate 1500 mg once daily ,double-blinded vs. placebo. Incident knee OA was defined as radiographic progression of >1mm minimum joint space narrowing (mJSN)in the medial tibiofemoral compartment, as previously assessed by the visual (manual) technique and by a new semi-automated method. Logistic regression analysis was used t ocalculate the odds ratio for the effect of the interventions. Results: After 2.5 years, 11.8% of control subjects developed knee OA. This incidence was decreased with glucosamine sulfate, either alone or in combination with the DEP, but not by the DEP alone. Since there was no statistical interaction between treatments, the 2x2 factorial design allowed analysis of patients receiving glucosamine sulfate (N = 204) vs. those not receiving it (N= 203), similarly for those on the DEP (N = 203) or not (N = 204). Glucosamine sulfate significantly decreased the risk of developing knee OA: odds ratio (OR) = 0.41(95% CI: 0.20–0.85, P = 0.02) by the manual JSN assessment method and OR = 0.42 (95% CI:0.20–0.92, P =0.03) by the semi-automated technique. Conversely, there was no decrease in risk with the DEP. Conclusions: Glucosamine sulfate decreased the risk of developing radiographic knee OA over 2.5 years in overweight, middle-aged women at risk, as determined by medial mJSN progression. Conversely a tailored diet and exercise program exerted no preventive effect, possibly because of the lower than expected effect on weigh tloss. [less ▲]

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See detailCytogenetic Studies of Rwandan Pediatric Patients Presenting with Global Developmental Delay, Intellectual Disability and/or Multiple Congenital Anomalies.
Uwineza, Annette; Hitayezu, Janvier; JAMAR, Mauricette ULg et al

in Journal of tropical pediatrics (2016)

Global developmental delay (GDD) is defined as a significant delay in two or more developmental domains: gross or fine motor, speech/language, cognitive, social/personal and activities of daily living ... [more ▼]

Global developmental delay (GDD) is defined as a significant delay in two or more developmental domains: gross or fine motor, speech/language, cognitive, social/personal and activities of daily living. Many of these children will go on to be diagnosed with intellectual disability (ID), which is most commonly defined as having an IQ <75 in addition to impairment in adaptive functioning. Cytogenetic studies have been performed in 664 Rwandan pediatric patients presenting GDD/ID and/or multiple congenital abnormalities (MCA). Karyotype analysis was performed in all patients and revealed 260 chromosomal abnormalities. The most frequent chromosomal abnormality was Down syndrome and then Edward syndrome and Patau syndrome. Other identified chromosomal abnormalities included 47,XX,+del(9)(q11), 46,XY,del(13)(q34) and 46,XX,der(22)t(10;22)(p10;p10)mat. In conclusion, our results highlight the high frequency of cytogenetically detectable abnormalities in this series, with implications for the burden on the healthcare. This study demonstrates the importance of cytogenetic analysis in patients with GDD/ID and MCA. [less ▲]

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See detailAssessment of the entering stock, migration dynamics and fish pass fidelity of european eel in the belgian meuse river
Nzau Matondo, Billy ULg; Benitez, Jean-Philippe ULg; Dierckx, Arnaud ULg et al

in River Research & Applications (2016)

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to ... [more ▼]

Migration dynamics of incoming eels in Belgium via Lixhe in the Meuse River were investigated using two fish passes with different configurations— net traps and automatic detection stations—as tools to distinguish resident and migrating eels. From April to September 2013, 435 eels (P50 length, 403 mm; range, 196–836 mm) were caught (daily maxima catch, 90 eels per day), 90% between 13 June and 1 August (50 days) and P50 on 19 July. Eels migrated mostly at 19–26 °C (P50, 24.4 °C), river discharge 65–314m3 s 1 (P50, 84m3 s 1), during the dark at 00:00–05:00 h and during both the waxing and waning phases of moonlight. From 396 eels tagged and released 0.3 km downstream of the Lixhe dam, 6.8% of them were recaptured, and 37.4% were detected. Migration flux was estimated at 7184 eels (0.863 t) using the markrecapture method and decreased to 1156 eels (0.139 t) using automatic transponder detection. Most eels probably migrated through a sluice located downstream of Lixhe to reach the upper Meuse via the Albert Canal. Eels moved almost independently to the configuration of the fish passes and their location, but most eels displayed fidelity to the fish pass where they were captured. Migrant eels showed a wide range of size and life stages, with a higher proportion of eels (80%) belonging to the yellow eel stage. A lower proportion of eels (6%) had a larger size and presented an advanced continental silvering process corresponding to the migrating stage before their transatlantic migration. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

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See detailRecurrent pulsations in Saturn’s high latitude magnetosphere
Mitchell, D.G.; Carbary, J.F.; Bunce, E.J. et al

in Icarus (2016)

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See detailDisplacement of an Electrically Charged Drop on a Vibrating Bath
Brandenbourger, Martin ULg; Vandewalle, Nicolas ULg; Dorbolo, Stéphane ULg

in Physical Review Letters (2016), 116

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See detailConstraints on the structure of 16 Cygni A and 16 Cygni B using inversion techniques
Buldgen, Gaël ULg; Reese, Daniel; Dupret, Marc-Antoine ULg

in Astronomy and Astrophysics (2016)

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution ... [more ▼]

Abstract Constraining mixing processes and chemical composition is a central problem in stellar physics as their impact on stellar age determinations leads to biases in our studies of stellar evolution, galactic history and exoplanetary systems. In two previous papers, we showed how seismic inversion techniques could offer strong constraints on such processes by pointing out weaknesses in theoretical models. We now apply our technique to the solar analogues 16CygA and 16CygB, being amongst the best targets in the Kepler field to test the diagnostic potential of seismic inversions. The combination of various seismic indicators helps to provide more constrained and accurate fundamendal parameters for these stars. We use the latest seismic, spectroscopic and interferometric observational constraints in the litterature for this system to determine reference models independently for both stars. We carry out seismic inversions of the acoustic radius, the mean density and a core conditions indicator. We note that a degeneracy exists for the reference models. Namely, changing the diffusion coefficient or the chemical composition within the observational values leads to 5% changes in mass, 3% changes in radius and up to 8% changes in age. We use acoustic radius and mean density inversions to improve our reference models then carry out inversions for a core conditions indicator. Thanks to its sensitivity to microscopic diffusion and chemical composition mismatches, we are able to reduce the mass dispersion to 2%, namely [0.96, 1.0] M_sun, the radius dispersion to 1%, namely [1.188, 1.200] R_sun and the age dispersion to 3%, namely [7.0, 7.4] Gy, for 16CygA. For 16CygB, we can check the consistency of the models but not reduce independently the age dispersion. Nonetheless, assuming consistency with the age of 16CygA helps to further constrain its mass and radius. [less ▲]

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See detailPrevention of Incisional Hernias by Prophylactic Mesh-augmented Reinforcement of Midline Laparotomies for Abdominal Aortic Aneurysm Treatment: A Randomized Controlled Trial.
Muysoms, Filip E.; DETRY, Olivier ULg; Vierendeels, Tijl et al

in Annals of surgery (2016), 263(4), 638-645

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high ... [more ▼]

BACKGROUND: The incidence of incisional hernias after abdominal aortic aneurysm repair is high. Prophylactic mesh-augmented reinforcement during laparotomy closure has been proposed in patients at high risk of incisional hernia. METHODS: A multicenter randomized trial was conducted on patients undergoing elective abdominal aortic aneurysm repair through a midline laparotomy (Clinical.Trials.gov: NCT00757133). In the study group, retromuscular mesh-augmented reinforcement was performed with a large-pore polypropylene mesh (Ultrapro, width 7.5 cm). The primary endpoint was the incidence of incisional hernias at 2-year follow-up. RESULTS: Between February 2009 and January 2013, 120 patients were recruited at 8 Belgian centers. Patients' characteristics at baseline were similar between groups. Operative and postoperative characteristics showed no difference in morbidity or mortality. The cumulative incidence of incisional hernias at 2-year follow-up after conventional closure was 28% (95% confidence interval [CI], 17%-41%) versus 0% (95% CI, 0%-6%) after mesh-augmented reinforcement (P < 0.0001; Fisher exact test). The estimated "freedom of incisional hernia" curves (Kaplan-Meier estimate) were significantly different across study arms (chi = 19.5, P < 0.0001; Mantel-Cox test). No adverse effect related to mesh-augmented reinforcement was observed, apart from an increased mean time to close the abdominal wall for mesh-augmented reinforcement compared with the control group: 46 minutes (SD, 18.6) versus 30 minutes (SD, 18.5), respectively (P < 0.001; Mann-Whitney U test). CONCLUSIONS: Prophylactic retromuscular mesh-augmented reinforcement of a midline laparotomy in patients with abdominal aortic aneurysm is safe and effectively prevents the development of incisional hernia during 2 years, with an additional mean operative time of 16 minutes. [less ▲]

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See detailRecommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean-Yves ULg; Cooper, Cyrus; Rizzoli, René et al

in Aging Clinical and Experimental Research (2016), 28(1), 47-58

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]

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See detailTea production between contract and none contract farmers in Phu Tho Province of Vietnam
Le Thi Kim, Oanh ULg; Bui Thi, Nga; Lebailly, Philippe ULg

in Scholars Journal of Agriculture and Veterinary Sciences (2016), 3(2), 117-122

Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as ... [more ▼]

Tea is one of key crops which substantially contributes to Vietnam’s annual exports, creates jobs and raises income for farmers. However, tea production farmers are still facing many difficulties such as low farm management, disease control, etc. Of which, tea consumption is considered to be the most challenge and the main reasons is the low cooperation between farmers and other stakeholders in the tea value chain. This study aims to look more deeply and find out the linkage and benefit of farmers in the model of cooperation between farmers and tea processing company through contract and none contract tea production in the study site. The results shown that the contract farming in tea production in the study sites was still not tightened and did not reflect clearly its real roles. However, it was gradually reflected it s roles as the fully contract farmers (worker farmers) received the highest productivity, turnover and value added and the most satisfied, the contract farmers (partly contract) achieved not as high benefit but quite satisfied with their results and contract. None contract farmers although received reasonable results recently but they still did not assure the production, they would like to engage in some kinds of cooperation in the future. [less ▲]

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See detailAerodynamic benefit for a cyclist by a following motorcycle
Blocken, Bert; Toparlar, Yasin; Andrianne, Thomas ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2016)

In recent years, many accidents have occurred between cyclists and in-race motorcycles, even yielding fatal injuries. The accidents and the potential aerodynamics issues have impelled the present authors ... [more ▼]

In recent years, many accidents have occurred between cyclists and in-race motorcycles, even yielding fatal injuries. The accidents and the potential aerodynamics issues have impelled the present authors to perform dedicated wind-tunnel measurements and Computational Fluid Dynamics (CFD) simulations to assess cyclist drag reduction when followed by one, two or three motorcycles. The 3D steady-state Reynolds-Averaged Navier-Stokes simulations with the standard k-ε model are validated by the wind-tunnel tests. The cyclist drag reduction goes up to 8.7% for a single trailing motorcycle and to 13.9% for three trailing motorcycles at a distance of 0.25 m behind the cyclist. This distance is not uncommon in elite races, as evidenced by the many recent accidents. The effect by a single following motorcycle at realistic short distances d=0.25 m (8.7%), d = 0.5 m (6.4%) and d=1 m (3.8%) is larger than that by a following car at realistic short distance d=5 m (1.4%). Therefore it could be argued that in-race motorcycles are not only more dangerous but also aerodynamically more influential. This study reinforces the necessity for the International Cycling Union to change the rules concerning in-race motorcycles, not only to avoid accidents but also to avoid unwanted aerodynamic benefits. [less ▲]

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See detailPreliminary report of mosquitoes survey at Tonga Lake (North-East Algeria)
Amara Korba, Raouf; Boukraa, Slimane ULg; Alayat, Moufdia Saoucen et al

in Advances in Environmental Biology (2016), 9(27), 288-294

Background: Mosquitoes are transmitters of several human diseases including, malaria, filariasis, West Nile virus and Rift Valley fever virus. To planified and succeful any mosquito vector control, a good ... [more ▼]

Background: Mosquitoes are transmitters of several human diseases including, malaria, filariasis, West Nile virus and Rift Valley fever virus. To planified and succeful any mosquito vector control, a good understanding of the occurrence of specific important vector species, their abundance and distribution are needed. Objectives: The present study aimed to identify the mosquito potential vectors distributed throughout Tonga Lake region, a part of National Park of El-Kala situated in northeastern Algeria and to discuss the epidemiological importance of these insects. Results: Thirteen species representing five genera were identified: Ae. brelandi, Ae. vexans, An. plumbeus, An. labranchiae, Cx. pipiens s. l., Cx. perexiguus, Cx. theileri, Cx. pusillus, Cx. modestus, Cx. impudicus, Cs. longiareolata, Cs. annulata, Ur. unguiculata. The dominant species was Cx. pipiens s. l. with more than 70%. Conclusion: The occurrence of Aedes, Anopheles and Culex is suggestive of the presence of a risk for vector-borne diseases such as malaria, West Nile fever, Rift Valley Fever and filariasis in the area. In this study, results on species diversity may help in the future planning of vector control measures. [less ▲]

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