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See detailLa vignette thérapeutique de l'étudiant. Le choix entre un inhibiteur de la DPP-4 et un inhibiteur des SGLT2 pour traiter le diabète de type 2 (2016)
SCHEEN, André ULg; PAQUOT, Nicolas ULg

in Revue Médicale de Liège (2016), 71(12), 579-585

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters ... [more ▼]

Summary : Two new classes of oral antidiabetic agents play an increasing role in the management of type 2 diabetes, dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and sodiumglucose cotransporters type 2 (SGLT2) inhibitors (gliflozins). After failure of a monotherapy with metformin (first pharmacological choice in type 2 diabetes), both may offer an alternative to the add-on of a sulphonylurea, especially in patients at risk of hypoglycaemia. However, the choice between a DPP-4 inhibitor and a SGLT2 inhibitor is not easy and should be oriented based upon the individual patient characteristics. The arguments in favour of one or another pharmacological class are discussed, considering a clinical case of a patient with coronary heart disease and type 2 diabetes not well controlled with metformin. [less ▲]

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See detailSoluble forms of CD46 are detected in Bos taurus plasma and neutralize BVDV, the bovine pestivirus
Alzamel, Nidal ULg; Bayrou, Calixte ULg; Decreux, Annabelle et al

in Comparative Immunology, Microbiology and Infectious Diseases (2016), 49

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides ... [more ▼]

The pestivirus bovine viral diarrhea virus (BVDV) is known to bind to the CD46 molecule, which subsequently promotes entry of the virus. Mapping of the BVD-virion-binding site has shown that two peptides, 66EQIV69 and 82GQVLAL87, located on antiparallel beta sheets in the most distal complement control protein module (CCP1), provide the attachment platform. In the present study, we reveal new CD46-encoding transcripts that are predicted to encode CCP1-containing soluble forms. Further, we show that the serum of most adult cattle contains soluble CD46 (sCD46) and that a recombinant soluble isoform neutralizes BVDV infectivity in an in vitro assay. We have then established an ELISA for determination of plasma sCD46 in a large cohort of animals. Overall, serum sCD46 amounts to 8 ± 18 ng/mL (mean ± SD, n = 440), with a IC [95-105] ranging from 6,4 to 9,8 ng/mL and extreme values between 0 and 178 ng/mL. We found that sCD46 is not detectable in fetal and neonatal sera and that its plasma concentration increases progressively up to adulthood. We also detected high- and low-sCD46 performers and show that this phenotype does not depend of environment. As modern rearing techniques make it possible to disseminate genetically-determined phenotypes very quickly in a population, a large-scale study examining whether high-sCD46 animals provide epidemiological protection against BVDV infection and transmission should be undertaken. [less ▲]

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See detailChemical composition and antimicrobial activity of essential oils of Ocimum basilicum, Ocimum canum and Ocimum gratissimum in function of harvesting time
Mith, Hasika; Yayi-Ladékan, Eléonore; Dosso Sika Kpoviessi, Salomé et al

in Journal of Essential Oil-Bearing Plants [=JEOBP] (2016), 19(6), 1413-1425

The chemical composition of essential oils obtained by hydrodistillation from aerial parts of Ocimum basilicum, Ocimum canum and Ocimum gratissimum from Benin as affected by harvesting time, were analyzed ... [more ▼]

The chemical composition of essential oils obtained by hydrodistillation from aerial parts of Ocimum basilicum, Ocimum canum and Ocimum gratissimum from Benin as affected by harvesting time, were analyzed by GC-FID (Gas chromatography-Flame ionization detector) and GC-MS (Gas chromatography-Mass spectrometry). Based on the composition analysis, major components were as follows: estragol (43.0-44.7%) and linalool (24.6 29.8%) in O. basilicum oils; carvacrol (12.0-30.8%) and p-cymene (19.5-26.2%) in O. canum oils; thymol (28.3-37.7%) and γ-terpinene (12.5-19.3 %) in O. gratissimum oils. Disc diffusion and broth microdilution assays were used to evaluate the antibacterial activity of essential oils and their main components against two foodborne bacteria, Listeria monocytogenes and Salmonella enterica serotype Typhimurium. The tested oils and their components exhibited notable antimicrobial activities against L. monocytogenes and S. Typhimurium. The O. canum and O. gratissimum oils collected at 7h and 19h showed significant higher activities against L. monocytogenes and S. Typhimurium (MICs and MBCs 0.34 - 2.5 μL/mL) (p < 0.05), whereas O. basilicum showed lower activity (MICs and MBCs 2.0 - 8.0 μL/mL) at any daytime of harvest, the weakest being at 19h (MIC and MBC 12.0 - 32.0 μL/mL). The daytime of harvest can influence the composition of oils and their activities on bacteria. [less ▲]

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See detailThe SHARDDS survey: First resolved image of the HD 114082 debris disk in the Lower Centaurus Crux with SPHERE
Wahhaj, Zahed; Milli, Julien; Kennedy, Grant et al

in Astronomy and Astrophysics (2016), 596

We present the first resolved image of the debris disk around the 16 ± 8 Myr old star, HD 114082. The observation was made in the H-band using the SPHERE instrument. The star is at a distance of 92 ± 6 pc ... [more ▼]

We present the first resolved image of the debris disk around the 16 ± 8 Myr old star, HD 114082. The observation was made in the H-band using the SPHERE instrument. The star is at a distance of 92 ± 6 pc in the Lower Centaurus Crux association. Using a Markov chain Monte Carlo analysis, we determined that the debris is likely in the form of a dust ring with an inner edge of 27.7[SUP]+2.8[/SUP][SUB]-3.5[/SUB] au, position angle -74.3°[SUP]+0.5[/SUP][SUB]-1.5[/SUB], and an inclination with respect to the line of sight of 6.7°[SUP]+3.8[/SUP][SUB]-0.4[/SUB]. The disk imaged in scattered light has a surface density that is declining with radius of r[SUP]-4[/SUP], which is steeper than expected for grain blowout by radiation pressure. We find only marginal evidence (2σ) of eccentricity and rule out planets more massive than 1.0 M[SUB]Jup[/SUB] orbiting within 1 au of the inner edge of the ring, since such a planet would have disrupted the disk. The disk has roughly the same fractional disk luminosity (L[SUB]disk[/SUB]/L[SUB]∗[/SUB] = 3.3 × 10[SUP]-3[/SUP]) as HR 4796 A and β Pictoris, however it was not detected by previous instrument facilities most likely because of its small angular size (radius 0.4''), low albedo ( 0.2), and low scattering efficiency far from the star due to high scattering anisotropy. With the arrival of extreme adaptive optics systems, such as SPHERE and GPI, the morphology of smaller, fainter, and more distant debris disks are being revealed, providing clues to planet-disk interactions in young protoplanetary systems. The reduced images are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/L4">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/L4</A> [less ▲]

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See detailQuantum fidelity of symmetric multipartite states
Neven, Antoine ULg; Mathonet, Pierre ULg; Gühne, Otfried et al

in Physical Review A (2016), 94

For two symmetric quantum states one may be interested in maximizing the overlap under local operations applied to one of them. The question arises whether the maximal overlap can be obtained by applying ... [more ▼]

For two symmetric quantum states one may be interested in maximizing the overlap under local operations applied to one of them. The question arises whether the maximal overlap can be obtained by applying the same local operation to each party. We show that for two symmetric multiqubit states and local unitary transformations this is the case; the maximal overlap can be reached by applying the same unitary matrix everywhere. For local invertible operations (stochastic local operations assisted by classical communication equivalence), however, we present counterexamples, demonstrating that considering the same operation everywhere is not enough. [less ▲]

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See detailCorrection of inertial oscillations by assimilation of HFradar data in a model of the Ligurian Sea
Vandenbulcke, Luc ULg; Barth, Alexander ULg; Beckers, Jean-Marie ULg

in Ocean Dynamics (2016)

This article aims at analyzing if high-frequency radar observations of surface currents allow to improve model forecasts in the Ligurian Sea, where inertial oscillations are a dominant feature. An ... [more ▼]

This article aims at analyzing if high-frequency radar observations of surface currents allow to improve model forecasts in the Ligurian Sea, where inertial oscillations are a dominant feature. An ensemble of ROMS models covering the Ligurian Sea, and nested in the Mediterranean Forecasting System, is coupled with two WERA high-frequency radars. A sensitivity study allows to determine optimal parameters for the ensemble filter. By assimilating observations in a single point, the obtained correction shows that the forecast error covariance matrix represents the inertial oscillations, as well as large- and meso-scale processes. Furthermore, it is shown that the velocity observations can correct the phase and amplitude of the inertial oscillations. Observations are shown to have a strong effect during approximately half a day, which confirms the importance of using a high temporal observation frequency. In general, data assimilation of HF radar observations leads to a skill score of about 30 % for the forecasts of surface velocity. [less ▲]

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See detailEnhanced Biogas Production During Anaerobic Digestion of Steam-pretreated Lignocellulosic Biomass from Williams Cavendish Banana Plants
Kamdem, Irenée ULg

in Waste and Biomass Valorization (2016)

In the context of green energy valorisation, this study reports the chemical analysis and improvement of biogas production via anaerobic digestion of treated and untreated agricultural waste ... [more ▼]

In the context of green energy valorisation, this study reports the chemical analysis and improvement of biogas production via anaerobic digestion of treated and untreated agricultural waste lignocellulosic biomass from Williams Cavendish banana plants (WCLB). With a worldwide annual production of 26 million tons of dry matter (DM), large amounts of this waste are abandoned in plantations after fruit harvesting. Steam explosion (SE) and steam cracking (SC) pretreatments were investigated at severity factors of 3.16 and 4.29, respectively, to improve the biogas potential over 135 days under mesophilic conditions. The study revealed a carbon (C)/nitrogen (N) ratio of 27.3, indicating that WCLB has sufficient N content for successful fermentation. The proportions of liquid and solid fractions recovered after SC were 20% and 80%, respectively, whereas SE yielded 17% and 83% liquid and solids, respectively. The neutral sugar content of the studied fractions indicated that glucose and xylose constituted the highest hexose and pentose fractions, respectively, in WCLB. The highest and lowest total biogas potentials were obtained from LFSC (280 mL g-1 of DM) and untreated WCLB (240 mL g-1 of DM), respectively. The methane yield from untreated WCLB and combined solid and liquid fractions from SE and SC were 40, 42, and 51%, respectively, of the theoretical methane potential. The maximum biogas production rate (7.8 mL g-1 d-1) was obtained with SFSC. This study reveals that SC deconstructs WCLB efficiently and thereby greatly enhances methane production. [less ▲]

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See detailDe l’émergence à la canonisation. Instances et supports du cursus honorum artistique et littéraire
Dozo, Björn-Olav ULg; Ellena, Laurence; Saint-Amand, Denis ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2016)

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See detailLa transaction pénale élargie face au contrôle de la Cour constitutionnelle
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (2016/39), 1847-1852

L'article fait le point sur les incidences d'une transaction intervenant en cours de procédure et sur le contrôle de cette transaction par le juge en application de l'article 216bis du Code d'instruction ... [more ▼]

L'article fait le point sur les incidences d'une transaction intervenant en cours de procédure et sur le contrôle de cette transaction par le juge en application de l'article 216bis du Code d'instruction criminelle. [less ▲]

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See detailStatistical study of Saturn's auroral electron properties with Cassini/UVIS FUV spectral images
Gustin, Jacques ULg; Grodent, Denis ULg; Radioti, Aikaterini ULg et al

in Icarus (2016)

About 2000 FUV spectra of different regions of Saturn's aurora, obtained with Cassini/UVIS from December 2007 to October 2014 have been examined. Two methods have been employed to determine the mean ... [more ▼]

About 2000 FUV spectra of different regions of Saturn's aurora, obtained with Cassini/UVIS from December 2007 to October 2014 have been examined. Two methods have been employed to determine the mean energy 〈E〉 of the precipitating electrons. The first is based on the absorption of the auroral emission by hydrocarbons and the second uses the ratio between the brightness of the Lyman-α line and the H2 total UV emission (Lyα/H2), which is directly related to 〈E〉 via a radiative transfer formalism. In addition, two atmospheric models obtained recently from UVIS polar occultations have been employed for the first time. It is found that the atmospheric model related to North observations near 70° latitude provides the results most consistent with constraints previously published. On a global point of view, the two methods provide comparable results, with 〈E〉 mostly in the 7–17 keV range with the hydrocarbon method and 〈E〉 in the 1–11 keV range with the Lyα/H2 method. Since hydrocarbons have been detected on ∼20% of the auroral spectra, the Lyα/H2 technique is more effective to describe the primary auroral electrons, as it is applicable to all spectra and allows an access to the lowest range of energies (≤5 keV), unreachable by the hydrocarbon method. The distribution of 〈E〉 is found fully compatible with independent HST/ACS constraints (emission peak in the 840–1450 km range) and FUSE findings (emission peaking at pressure level ≤0.2 µbar). In addition, 〈E〉 exhibits enhancements in the 3 LT–10 LT sector, consistent with SKR intensity measurements. An energy flux–electron energy diagram built from all the data points strongly suggests that acceleration by field-aligned potentials as described by Knight's theory is a main mechanism responsible for electron precipitation creating the aurora. Assuming a fixed electron temperature of 0.1 keV, a best-fit equatorial electron source population density of 3 × 103 m−3 is derived, which matches very well to the plasma properties observed with Cassini MAG and CAPS/ELS instruments. However, several auroral regions are characterized by relatively high 〈E〉 and low energy flux, suggesting that additional processes such as plasma injections or magnetic reconnections must be accounted for to explain the emission in these regions. The Lyα/H2 ratio technique can be used to build maps of 〈E〉 from single spectral images. As expected, preliminary results show that the spatial distribution of 〈E〉 is not uniform, as seen on Jupiter. Our study reveals that a fraction of the aurora is due to very low energy electrons (<1 keV). Even in this case, comparisons between observed and modeled spectra show that 100 eV is a suitable value to represent the average energy of the secondary electrons. [less ▲]

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See detailSustainability and management control. Exploring and theorizing control patterns in large European firms
Crutzen, Nathalie ULg; Zvezdov, Dimitar; Schaltegger, Stefan

in Journal of Cleaner Production (2016), Online version

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See detailNuclear Medicine techniques in transplantation
LOVINFOSSE, Pierre ULg; HUSTINX, Roland ULg

in Clinical and Translational Imaging (2016)

Organ transplantation has grown over the past decades thanks to major improvements in surgical techniques and immunosuppressive treatment. Nuclear medicine is used for non-invasively improving the ... [more ▼]

Organ transplantation has grown over the past decades thanks to major improvements in surgical techniques and immunosuppressive treatment. Nuclear medicine is used for non-invasively improving the selection of candidates to give or receive a transplant, for monitoring graft recipients and for diagnosing and managing early and late complications. This review describes the clinical role of nuclear medicine in transplantation and discusses some of the possible perspectives. [less ▲]

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See detailActive Expiration and the Measurement of Central Venous Pressure
MAGDER, S; SERRI, K; VERSCHEURE, Sara ULg et al

in Journal of Intensive Care Medicine (2016)

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See detailProtein encapsulation and release from PEO-b-polyphosphoester templated calcium carbonate particles
Ergül, Zeynep ULg; Cordonnier, Thomas; Debuigne, Antoine ULg et al

in International Journal of Pharmaceutics (2016), 513

Calcium carbonate particles are promising candidates as proteins carriers for their controlled delivery in the body. The present paper aims at investigating the protein encapsulation by in situ ... [more ▼]

Calcium carbonate particles are promising candidates as proteins carriers for their controlled delivery in the body. The present paper aims at investigating the protein encapsulation by in situ precipitation of calcium carbonate particles prepared by a process based on supercritical CO2 and using a new type of degradable well-defined double hydrophilic block copolymers composed of poly(ethylene oxide) and polyphosphoester blocks acting as templating agent for the calcium carbonate. For this study, lysozyme was chosen as a model for therapeutic protein for its availability and ease of detection. It was found that by this green process, loading into the CaCO3 microparticles with a diameter about 2 mm can be obtained as determined by scanning electron microscopy. A protein loading up to 6.5% active lysozyme was measured by a specific bioassay (Micrococcus lysodeikticus). By encapsulating fluorescent-labelled lysozyme (lysozyme-FITC), the confocal microscopy images confirmed its encapsulation and suggested a core–shell distribution of lysozyme into CaCO3, leading to a release profile reaching a steady state at 59% of release after 90 min. [less ▲]

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See detailRegional sea level changes for the 20th and the 21st century induced by the regional variability in Greenland ice sheet surface mass loss
Meyssignac, B.; Fettweis, Xavier ULg; Chevrier, R. et al

in Journal of Climate (2016), online

Surface mass balance (SMB) variations of the Greenland ice sheet (GrIS) has been identified as an important contributor to contemporary and projected global mean sea level variations but their impact on ... [more ▼]

Surface mass balance (SMB) variations of the Greenland ice sheet (GrIS) has been identified as an important contributor to contemporary and projected global mean sea level variations but their impact on the regional sea level change pattern is still poorly known. This study provides for the first time, consistent estimates (i.e. computed with the same models over the past -1900-2015- and over the future -2015-2100-) of GrIS SMB over 1900-2100 based on the output of 32 atmospheric-ocean General Circulation Models and Earth system models involved in the Climate Model Intercomparison Project phase 5 (CMIP5). It is based on a downscaling technique calibrated against the MAR regional climate model in order to calculate an ensemble of 32 Greenland SMB estimates at regional scale. Because the GrIS SMB does not respond uniformly to greenhouse gases (GHG) emissions. the southern part of the GrIS is more sensitive to climate warming. This study shows that it should be in imbalance in the 21st century sooner that the northern part. This regional variability affects significantly the associated relative sea level pattern over the entire ocean and particularly along the eastern coast of US and the northern coast of Europe. This highlights the necessity of taking into account GrIS regional SMB changes to evaluate accurately relative sea level changes in future projections. [less ▲]

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See detailOptimizing the subwavelength grating of L-band annular groove phase masks for high coronagraphic performance
Vargas Catalán, E.; Huby, Elsa ULg; Forsberg, P. et al

in Astronomy and Astrophysics (2016), 595

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several ... [more ▼]

Context. The annular groove phase mask (AGPM) is one possible implementation of the vector vortex coronagraph, where the helical phase ramp is produced by a concentric subwavelength grating. For several years, we have been manufacturing AGPMs by etching gratings into synthetic diamond substrates using inductively coupled plasma etching. <BR /> Aims: We aim to design, fabricate, optimize, and evaluate new L-band AGPMs that reach the highest possible coronagraphic performance, for applications in current and forthcoming infrared high-contrast imagers. <BR /> Methods: Rigorous coupled wave analysis (RCWA) is used for designing the subwavelength grating of the phase mask. Coronagraphic performance evaluation is performed on a dedicated optical test bench. The experimental results of the performance evaluation are then used to accurately determine the actual profile of the fabricated gratings, based on RCWA modeling. <BR /> Results: The AGPM coronagraphic performance is very sensitive to small errors in etch depth and grating profile. Most of the fabricated components therefore show moderate performance in terms of starlight rejection (a few 100:1 in the best cases). Here we present new processes for re-etching the fabricated components in order to optimize the parameters of the grating and hence significantly increase their coronagraphic performance. Starlight rejection up to 1000:1 is demonstrated in a broadband L filter on the coronagraphic test bench, which corresponds to a raw contrast of about 10[SUP]-5[/SUP] at two resolution elements from the star for a perfect input wave front on a circular, unobstructed aperture. <BR /> Conclusions: Thanks to their exquisite performance, our latest L-band AGPMs are good candidates for installation in state of the art and future high-contrast thermal infrared imagers, such as METIS for the E-ELT. [less ▲]

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See detailIncreased Risk of Group B Streptococcus Invasive Infection in HIV-Exposed but Uninfected Infants: A Review of the Evidence and Possible Mechanisms.
DAUBY, Nicolas; CHAMEKH, Mustapha; MELIN, Pierrette ULg et al

in Frontiers in Immunology (2016), 7

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are ... [more ▼]

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are at increased risk of infectious morbidity, as compared to HIV-unexposed uninfected infants (HUU). A higher susceptibility to GBS infections has been reported in HEU infants, particularly late-onset diseases and more severe manifestations of GBS diseases. We review here the possible explanations for increased susceptibility to GBS infection. Maternal GBS colonization during pregnancy is a major risk factor for early-onset GBS invasive disease, but colonization rates are not higher in HIV-infected compared to HIV-uninfected pregnant women, while selective colonization with more virulent strains in HIV-infected women is suggested in some studies. Lower serotype-speci c GBS maternal antibody transfer and quantitative and qualitative defects of innate immune responses in HEU infants may play a role in the increased risk of GBS invasive disease. The impact of maternal antiretroviral treatment and its consequences on immune activation in HEU newborns are important to study. Maternal immunization presents a promising intervention to reduce GBS burden in the growing HEU population. [less ▲]

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See detailCarbon balance of an intensively grazed grassland in southern Belgium
Gourlez de la Motte, Louis ULg; Jérôme, Elisabeth; Mamadou, Ossénatou et al

in Agricultural and Forest Meteorology (2016), 228-229

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See detailSensitivity of the annual net ecosystem exchange to the cospectral model used for high frequency loss corrections at a grazed grassland site
Mamadou, Ossenatou; Gourlez de la Motte, Louis ULg; De Ligne, Anne ULg et al

in Agricultural and Forest Meteorology (2016), 228-229

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See detailFrance and the Armenian genocide
Grandjean, Geoffrey ULg

in Social History (2016), 49(100), 659-661

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See detailReducing the global burden of HTLV-1 infection: An agenda for research and action
Willems, Luc ULg; Hasegawa, Hideki; Accolla, Roberto et al

in Antiviral Research (2016), 137(2017), 41-48

Even though an estimated 10e20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has ... [more ▼]

Even though an estimated 10e20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines. [less ▲]

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See detailMalachite and heterogenite behavior during the locked-cycle recycling of process water in flotation of copper-cobalt oxide ores
Shengo, Michel; Gaydardzhiev, Stoyan ULg; Kalenga, Pierre

in International Journal of Mineral Processing (2016), 157

The behavior of malachite and heterogenite was investigated during the process water recycling in flotation of copper-cobalt oxide ores from the deposit of Luiswishi located in Haut-Katanga province (DRC ... [more ▼]

The behavior of malachite and heterogenite was investigated during the process water recycling in flotation of copper-cobalt oxide ores from the deposit of Luiswishi located in Haut-Katanga province (DRC). A synthetic mill wastewater (SMWW) was utilized as feed water alone and in mixture with water recovered from the flotation tails in view to achieve at the laboratory scale the locked-cycle recycling of the industrial mill wastewater (IMWW). To simulate the chemical species presence in the pulp and their effects on the flotation of malachite and heterogenite, calcium, magnesium and bicarbonate ions were added to the feed water and the recoveries of copper and cobalt followed during the roughing flotation stage. The concentrate XRD and SEM analysis together with the floated minerals microanalyses by EDX spectroscopy, leaching tests of mono-minerals followed by the Pourbaix diagrams construction and DRIFT spectroscopy analyses, have enabled identifying changes in the surface properties of malachite and heterogenite interfering on the recovery of copper (40 %) and cobalt (58 %) with a significant drop in their concentrate grades (7.3 % Cu and 2.7 % Co). The deterioration of the concentrate characteristics results also from the gangue minerals entrainment. A better description of the valuable minerals behaviour in the SMWW presence could enable designing strategies in view enhancing their floatability during the locked-cycle recycling of water. [less ▲]

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See detailIntegrating corporate sustainability assessment, management accounting, control, and reporting
Maas, Karen; Schaltegger, Stefan; Crutzen, Nathalie ULg

in Journal of Cleaner Production (2016), 136

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See detailSpecial Volume: The Integration of Corporate Sustainability Assessment, Management Accounting, Control, and Reporting
Maas, Karen; Schaltegger, Stefan; Crutzen, Nathalie ULg

in Journal of Cleaner Production (2016), 136

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See detailMyoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes
Blomme, Arnaud; Fahmy, Karim; Peulen, Olivier ULg et al

in Oncotarget (2016)

Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique ... [more ▼]

Exosomes are communication mediators participating in the intercellular exchange of proteins, metabolites and nucleic acids. Recent studies have demonstrated that exosomes are characterized by a unique proteomic composition that is distinct from the cellular one. The mechanisms responsible for determining the proteome content of the exosomes remain however obscure. In the current study we employ ultrastructural approach to validate a novel exosomal protein myoferlin. This is a multiple C2-domain containing protein, known for its conserved physiological function in endocytosis and vesicle fusion biology. Emerging studies demonstrate that myoferlin is frequently overexpressed in cancer, where it promotes cancer cell migration and invasion. Our data expand these ndings by showing that myoferlin is a general component of cancer cell derived exosomes from different breast and pancreatic cancer cell lines. Using proteomic analysis, we demonstrate for the rst time that myoferlin depletion in cancer cells leads to a signi cantly modulated exosomal protein load. Such myoferlin-depleted exosomes were also functionally de cient as shown by their reduced capacity to transfer nucleic acids to human endothelial cells (HUVEC). Beyond this, myoferlin-depleted cancer exosomes also had a signi cantly reduced ability to induce migration and proliferation of HUVEC. The present study highlights myoferlin as a new functional player in exosome biology, calling for novel strategies to target this emerging oncogene in human cancer. [less ▲]

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See detailReprint of Advancing the integration of corporate sustainability measurement, management and reporting
Maas, Karen; Schaltegger, Stefan; Crutzen, Nathalie ULg

in Journal of Cleaner Production (2016), 136

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See detailWhole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA
Gillet, Nicolas ULg; Willems, Luc ULg

in Retrovirology (2016)

Controversy exists regarding the association of bovine leukemia virus (BLV) and breast cancer. PCR-based experimental evidence indicates that BLV DNA is present in breast tissue and that as many as 37% of ... [more ▼]

Controversy exists regarding the association of bovine leukemia virus (BLV) and breast cancer. PCR-based experimental evidence indicates that BLV DNA is present in breast tissue and that as many as 37% of cancer cases may be attributable to viral exposure. Since this association might have major consequences for human health, we evaluated 51 whole genomes of breast cancer samples for the presence of BLV DNA. Among 32 billion sequencing reads retrieved from the NCBI database of genotype and phenotype, none mapped on different strains of the BLV genome. Controls for sequence divergence and proviral loads further validated the approach. This unbiased analysis thus excludes a clonal insertion of BLV in breast tumor cells and strongly argues against an association between BLV and breast cancer. [less ▲]

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See detailPrevalence of viruses infecting plantain (Musa sp., AAB genome) in the major growing regions in Cote d'Ivoire
Kouadio, Kouakou Théodore; De Clerck, Caroline; Agneroh, Thérèse Atcham et al

in African Journal of Agricultural Research (2016), 11(44), 4532-4541

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See detailNon-reef environments impact the diversification of extant jacks, remoras and allies (Carangoidei, Percomorpha)
Frederich, Bruno ULg; Marrama, Giuseppe; Carnevale, Giorgio et al

in Proceedings of the Royal Society B : Biological Sciences (2016), 283

Various factors may impact the processes of diversification of a clade. In the marine realm, it has been shown that coral reef environments have promoted diversification in various fish groups. With the ... [more ▼]

Various factors may impact the processes of diversification of a clade. In the marine realm, it has been shown that coral reef environments have promoted diversification in various fish groups. With the exception of requiem sharks, all the groups showing a higher level of diversity in reefs than in non-reef habitats have diets based predominantly on plankton, algae or benthic invert- ebrates. Here we explore the pattern of diversification of carangoid fishes, a clade that includes numerous piscivorous species (e.g. trevallies, jacks and dolphinfishes), using time-calibrated phylogenies as well as ecological and morphological data from both extant and fossil species. The study of caran- goid morphospace suggests that reef environments played a role in their early radiation during the Eocene. However, contrary to the hypothesis of a reef-association-promoting effect, we show that habitat shifts to non-reef environments have increased the rates of morphological diversification (i.e. size and body shape) in extant carangoids. Piscivory did not have a major impact on the tempo of diversification of this group. Through the ecological radiation of carangoid fishes, we demonstrate that non-reef environments may sustain and promote processes of diversification of different marine fish groups, at least those including a large proportion of piscivorous species. [less ▲]

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See detailAccurate drift time determination by traveling wave ion mobility spectrometry: The concept of the diffusion calibration
Kune, Christopher ULg; Far, Johann ULg; De Pauw, Edwin ULg

in Analytical Chemistry (2016), 88

Ion mobility spectrometry (IMS) is a gas phase separation technique which relies on differences in collision cross section (CCS) of ions. Ionic clouds of unresolved conformers overlap if the CCS ... [more ▼]

Ion mobility spectrometry (IMS) is a gas phase separation technique which relies on differences in collision cross section (CCS) of ions. Ionic clouds of unresolved conformers overlap if the CCS difference is below the instrumental resolution expressed as CCS/ΔCCS. The experimental arrival time distribution (ATD) peak is then a superimposition of the various contributions weighted by their relative intensities. This paper introduces a strategy for accurate drift time determination using traveling wave ion mobility spectrometry (TWIMS) of poorly resolved or unresolved conformers. This method implements through a calibration procedure the link between the peak full width at half maximum (FWHM) and the drift time of model compounds for wide range of settings for wave heights and velocities. We modified a Gaussian equation which achieves the deconvolution of ATD peaks where the FWHM is fixed according to our calibration procedure. The new fitting Gaussian equation only depends on two parameters: The apex of the peak (A) and the mean drift time value (μ). The standard deviation parameter (correlated to FWHM) becomes a function of the drift time. This correlation function between μ and FWHM is obtained using the TWIMS calibration procedure which determines the maximum instrumental ion beam diffusion under limited and controlled space charge effect using ionic compounds which are detected as single conformers in the gas phase. This deconvolution process has been used to highlight the presence of poorly resolved conformers of crown ether complexes and peptides leading to more accurate CCS determinations in better agreement with quantum chemistry predictions [less ▲]

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See detailOrtho-to-para abundance ratios of NH2in 26 comets: implications for the real meaning of OPRs
Shinnaka, Yoshiharu; Kawakita, Hideyo; Jehin, Emmanuel ULg et al

in Monthly Notices of the Royal Astronomical Society (2016), 462

Abundance ratios of nuclear-spin isomers for cometary molecules having identical protons, such as water and ammonia, have been measured and discussed from the viewpoint that they are primordial characters ... [more ▼]

Abundance ratios of nuclear-spin isomers for cometary molecules having identical protons, such as water and ammonia, have been measured and discussed from the viewpoint that they are primordial characters in comet. In the case of ammonia, its ortho-to-para abundance ratio (OPR) is usually estimated from OPRs of NH2 because of difficulty in measuring OPR of ammonia directly. We report our survey for OPRs of NH2 in 26 comets. A weighted mean of ammonia OPRs for the comets is 1.12 ± 0.01 and no significant difference is found between the Oort Cloud comets and the Jupiter-family comets. These values correspond to ∼30 K as nuclear-spin temperatures. The OPRs of ammonia in comets probably reflect the physicochemical conditions in coma, rather than the conditions for the molecular formation or condensation in the pre-solar molecular cloud/the solar nebula, based on comparison of OPRs (and nuclear-spin temperatures) of ammonia with those of water, 14N/15N ratios in ammonia, and D/H ratios in water. The OPRs could be reset to a nuclear-spin weights ratio in solid phase and modified by interactions with protonated ions like H3O+, water clusters (H2O)n, ice grains, and paramagnetic impurities (such as O2 molecules and grains) in the inner coma gas. Relationship between the OPRs of ammonia and water is a clue to understanding the real meaning of the OPRs. [less ▲]

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See detailThe puzzling properties of the magnetic O star Tr16-22
Nazé, Yaël ULg; Barbá, Rodolfo; Bagnulo, Stefano et al

in Astronomy and Astrophysics (2016), 596(A44), 1-7

Context. The detection of bright, hard, and variable X-ray emission in Tr16-22 prompted spectropolarimetric observations of this star, which in turn led to the discovery of a surface magnetic field. <BR ... [more ▼]

Context. The detection of bright, hard, and variable X-ray emission in Tr16-22 prompted spectropolarimetric observations of this star, which in turn led to the discovery of a surface magnetic field. <BR /> Aims: We want to further constrain the properties of this star, in particular to verify whether X-ray variations are correlated to changes in optical emission lines and magnetic field strength, as expected from the oblique rotator model that is widely accepted for magnetic O stars. <BR /> Methods: We have obtained new low-resolution spectropolarimetric and long-term high-resolution spectroscopic monitoring of Tr16-22, and we also analyse new, serendipitous X-ray data. <BR /> Results: The new X-ray observations are consistent with previous data, but their addition does not help to solve the ambiguity in the variation timescale because of numerous aliases. No obvious periodicity or any large variations are detected in the spectropolarimetric data of Tr16-22 obtained over three months. The derived field values appear to be in line with previous measurements, suggesting constancy of the field (though the possibility of small, short-term field variations cannot be excluded). Variations in the equivalent widths of Hα are very small, and they do not appear to be related to the X-ray timescale; the overall lack of large variations in optical emission lines is consistent with the magnetic field constancy. In addition, variations of the radial velocities indicate that Tr16-22 is probably a SB1 binary with a very long period. <BR /> Conclusions: Our new measurements of optical emission lines and magnetic field strength do not show an obvious correlation with X-ray variations. Our current data thus cannot be interpreted in terms of the common model, which assumes the electromagnetic emission associated with a wind confined by a dipolar field tilted with respect to the rotation axis. However, the sampling is imperfect and new data are needed to further constrain the actual periodicity of the various observed phenomena. If inconsistencies are confirmed, then we will need to consider alternative scenarios. Based on XMM-Newton observations (ObsIDs 0691970101, 0742850301, 0742850401, 0762910401) and ESO data (Prog. 386.D-0624A, 086.D-0997B, 089.D-0975A, 091.D-0090B, 095.D-0082).The reduced polarisation spectra (as ascii files) are only available at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (<A href="http://130.79.128.5">http://130.79.128.5</A>) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/A44">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/596/A44</A> [less ▲]

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See detailGaia Data Release 1. Summary of the astrometric, photometric, and survey properties
Gaia Collaboration; Brown, A. G. A.; Vallenari, A. et al

in Astronomy and Astrophysics (2016), 595

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. <BR ... [more ▼]

Context. At about 1000 days after the launch of Gaia we present the first Gaia data release, Gaia DR1, consisting of astrometry and photometry for over 1 billion sources brighter than magnitude 20.7. <BR /> Aims: A summary of Gaia DR1 is presented along with illustrations of the scientific quality of the data, followed by a discussion of the limitations due to the preliminary nature of this release. <BR /> Methods: The raw data collected by Gaia during the first 14 months of the mission have been processed by the Gaia Data Processing and Analysis Consortium (DPAC) and turned into an astrometric and photometric catalogue. <BR /> Results: Gaia DR1 consists of three components: a primary astrometric data set which contains the positions, parallaxes, and mean proper motions for about 2 million of the brightest stars in common with the Hipparcos and Tycho-2 catalogues - a realisation of the Tycho-Gaia Astrometric Solution (TGAS) - and a secondary astrometric data set containing the positions for an additional 1.1 billion sources. The second component is the photometric data set, consisting of mean G-band magnitudes for all sources. The G-band light curves and the characteristics of 3000 Cepheid and RR Lyrae stars, observed at high cadence around the south ecliptic pole, form the third component. For the primary astrometric data set the typical uncertainty is about 0.3 mas for the positions and parallaxes, and about 1 mas yr[SUP]-1[/SUP] for the proper motions. A systematic component of 0.3 mas should be added to the parallax uncertainties. For the subset of 94 000 Hipparcos stars in the primary data set, the proper motions are much more precise at about 0.06 mas yr[SUP]-1[/SUP]. For the secondary astrometric data set, the typical uncertainty of the positions is 10 mas. The median uncertainties on the mean G-band magnitudes range from the mmag level to 0.03 mag over the magnitude range 5 to 20.7. <BR /> Conclusions: Gaia DR1 is an important milestone ahead of the next Gaia data release, which will feature five-parameter astrometry for all sources. Extensive validation shows that Gaia DR1 represents a major advance in the mapping of the heavens and the availability of basic stellar data that underpin observational astrophysics. Nevertheless, the very preliminary nature of this first Gaia data release does lead to a number of important limitations to the data quality which should be carefully considered before drawing conclusions from the data. [less ▲]

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See detailThe effects of timing of insemination and GnRH treatment on pregnancy rates of N’Dama females after induction of oestrus with progestin
Okouyi M’foumou W’otari, Marcel; Hanzen, Christian ULg

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (2016), 69(2), 73-78

The aim of this clinical trial was to quantify the results of pregnancy after treating trypanotolerant N'Dama female cattle (n=168) using a CIDR® (1.38g of progesterone) inserted for seven days. An ... [more ▼]

The aim of this clinical trial was to quantify the results of pregnancy after treating trypanotolerant N'Dama female cattle (n=168) using a CIDR® (1.38g of progesterone) inserted for seven days. An intramuscular (IM) PG injection (500µg of cloprostenol) was administered two days before removal of the device. Subsequently, an IM injection of 400UI of eCG was administered when the device was removed. The animals were inseminated respectively 48 (Group 1) and 72 hours (Group 2) after removal of the CIDR®. In both groups, half the animals were treated with 4.2µg of buserelin acetate and the other half with 1ml of physiological saline. Four protocols were thus tested: CIDR-PG-eCG/IA48h, CIDR-PG-eCG/IA48h/GnRH+, CIDR-PG-eCG/IA72h, and CIDR-PG-eCG/IA72h/GnRH+. A pregnancy diagnosis has been done by echography 45 to 60 days after insemination. The average pregnancy rate was 37.5% (n=168). That of the adult cows (43.2%, n=111) was significantly (P < 0.03) higher than that of the heifers (26.3%, n=57). The pregnancy rate observed in animals in Group 2 (48.8%) was significantly higher (P < 0.002) than that observed in the animals in Group 1 (26.2%). Physiological condition and the injection of GnRH at the time of insemination had no significant impact on the pregnancy rate. The hormonal protocol using CIDR-PG-eCG (400UI) and a timed artificial insemination 72 h later improves the pregnancy rates in the N’Dama female. [less ▲]

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See detailNitrogen isotopic ratios of NH 2 in comets: implication for 15 N-fractionation in cometary ammonia
Shinnaka, Yoshiharu; Kawakita, Hideyo; Jehin, Emmanuel ULg et al

in Monthly Notices of the Royal Astronomical Society (2016), 462

The isotopic ratios are diagnostics for the physico-chemical conditions governing molecular formation. In comets, 14N/15N ratios have been measured from HCN in three comets and from CN in more than 20 ... [more ▼]

The isotopic ratios are diagnostics for the physico-chemical conditions governing molecular formation. In comets, 14N/15N ratios have been measured from HCN in three comets and from CN in more than 20 comets. Those ratios are enriched in 15N compared to the Sun by a factor of ∼3, have a small diversity and do not depend on the dynamical type of the comets. The origin of this high 15N-fractionation is still in debate because CN probably comes not only from HCN, but also from other materials (such as polymers or organic dusts) in the coma. Consequently, an interpretation of the isotopic ratios in cometary CN is quite complicated due to the multiple possible parents of CN. In contrast with CN, the isotopic ratios of nitrogen in NH3 give us a much clearer interpretation than in CN because NH3 is directly incorporated in the nuclear ices. To estimate the 14N/15N ratios in NH3, 14N/15N ratios have been determined from high-resolution spectra of NH2 in the optical wavelength region. NH2 is indeed a dominant photodissociation product of NH3. Those ratios were also found to be enriched in 15N compared to the Sun by a factor of ∼3. In this paper, we present 14N/15N ratios in NH2 for an additional sample of 16 comets. Our sample includes short-period comets as well as long-period comets. We found that the 14N/15N ratios in cometary NH2 also show a small dispersion and do not depend on the dynamical origin of the comets. [less ▲]

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See detailThe Gaia mission
Gaia Collaboration; Prusti, T.; de Bruijne, J. H. J. et al

in Astronomy and Astrophysics (2016), 595

Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept ... [more ▼]

Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page. <A href="http://www.cosmos.esa.int/gaia">http://www.cosmos.esa.int/gaia</A> [less ▲]

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See detailSupramolecular influence on cis–trans isomerization probed by ion mobility spectrometry
Czerwinska, Izabella; Kulesza, Alexander; Choi, Changmin et al

in Physical Chemistry Chemical Physics [=PCCP] (2016), 18

We used tandem ion mobility spectrometry measurements to investigate how the photo-isomerization of a chromophore (a methylpyridinium derivative) is affected by the complexation with a crown ether. A ... [more ▼]

We used tandem ion mobility spectrometry measurements to investigate how the photo-isomerization of a chromophore (a methylpyridinium derivative) is affected by the complexation with a crown ether. A dramatic blue-shift of the photo-isomerization spectrum was observed upon complexation, which could be well reproduced by ab initio calculations. Our results support that the observed changes in the photo-physical properties of the chromophore originate from the charge-solvation of its pyridinium moiety by the host cage. [less ▲]

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See detailChandra View of Magnetically Confined Wind in HD191612: Theory Versus Observations
Nazé, Yaël ULg; ud-Doula, Asif; Zhekov, Svetozar A.

in Astrophysical Journal (2016), 831(#138), 11

High-resolution spectra of the magnetic star HD 191612 were acquired using the Chandra X-ray Observatory at both maximum and minimum emission phases. We confirm the flux and hardness variations previously ... [more ▼]

High-resolution spectra of the magnetic star HD 191612 were acquired using the Chandra X-ray Observatory at both maximum and minimum emission phases. We confirm the flux and hardness variations previously reported with XMM-Newton, demonstrating the high repeatability of the behavior of HD 191612 over a decade. The line profiles appear typical for magnetic massive stars: no significant line shift, relatively narrow lines for high-Z elements, and formation radius at about 2 {R}[SUB]* [/SUB]. Line ratios confirm the softening of the X-ray spectrum at the minimum emission phase. Shift or width variations appear of limited amplitude at most (slightly lower velocity and slightly increased broadening at minimum emission phase, but within 1–2σ of values at maximum). In addition, a fully self-consistent 3D magnetohydrodynamic simulation of the confined wind in HD 191612 was performed. The simulation results were directly fitted to the data, leading to a remarkable agreement overall between them. [less ▲]

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See detailOn the Variable Dilatancy Angle in Rocks Around Underground Galleries
Salehnia, Fatemeh ULg; Collin, Frédéric ULg; Charlier, Robert ULg

in Rock Mechanics & Rock Engineering (2016)

Correct estimation of the dilatant behavior of a rock has an essential role in a realistic numerical simulation of the fracturing threshold during the rock deformation process and its post-failure ... [more ▼]

Correct estimation of the dilatant behavior of a rock has an essential role in a realistic numerical simulation of the fracturing threshold during the rock deformation process and its post-failure response, based on experimental and field observations. This importance has been poorly treated in most of the numerical analyses dealing with the rock engineering common problems such as deep excavations. The dilatancy angle as a commonly used parameter for describing the dilatation response of a rock is mostly simplified to be a constant value. Contrarily, a literature review declares the inadequacy of this approach in those rock mechanics applications. In the present paper, a new formula for considering the variable dilatancy angle is presented which relates this parameter to the plastic shear strain in the course of a loading procedure. It is aimed at characterizing an evolution of the dilatant or contracting volumetric response of a rock as well as giving the possibility to simulate a dilatant/contracting transitional behavior. The model is applied to simulate the development of strain localization, in shear band mode, within the inevitable excavation damaged zone created around an underground opening in rock. It is illustrated that using the model of variable dilatancy angle in a deep excavation modeling could help to better reproduce the fractures development around the opening in the course of tunneling. [less ▲]

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See detailLoadbearing capacity criteria in fire resistance testing
Dumont, Fabien ULg; Wellens, Eric ULg; Gernay, Thomas ULg et al

in Materials and Structures (2016), 49(11), 4565-4581

The European system for fire testing and classification of loadbearing building elements lacks consistency because the two standards that have to be applied prescribe different criteria for assessing the ... [more ▼]

The European system for fire testing and classification of loadbearing building elements lacks consistency because the two standards that have to be applied prescribe different criteria for assessing the loadbearing performance. This article analyzes the implications of the present conflict between the standard for testing and the standard for classification. The prescribed criteria for loadbearing performance are related to the exceedance of deflection and rate of deflection thresholds. A database of 46 fire resistance tests performed at the University of Liege is collected that contains the time at which these thresholds are reached in fire tests with different typologies of elements (walls, floors, columns and beams). Then, the loadbearing performance (and hence the fire resistance rating) can be derived according to the two standards. The evolutions of deflection and rate of deflection during the tests are also analyzed to gain a better understanding of the adequacy of the standards. The selection of one or the other standard affects the time at which “failure” is deemed to occur in fire tests. Statistically speaking, the difference in terms of failure time that results from using one or the other standard has a 25% probability to exceed 10%. In certain cases, this results in a difference in fire resistance rating; this was observed for 3 of the analyzed tests. The apparent contradiction in two codes in application has potential practical implications and therefore needs to be solved. The article suggests some guidelines for defining homogenized and consistent criteria. [less ▲]

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See detailRevealed preference tests of collectively rational consumption behavior: formulations and algorithms
Talla Nobibon, Fabrice; Cherchye, Laurens; Crama, Yves ULg et al

in Operations Research (2016), 64(6), 11971216

This paper focuses on revealed preference tests of the collective model of household consumption. We start by showing that the decision problems corresponding to testing collective rationality are {\sc np ... [more ▼]

This paper focuses on revealed preference tests of the collective model of household consumption. We start by showing that the decision problems corresponding to testing collective rationality are {\sc np}-complete. This makes the application of these tests problematic for (increasingly available) large(r) scale data sets. We then present two approaches to overcome this negative result. First, we introduce exact algorithms based on mixed-integer programming ({\sc mip}) formulations of the collective rationality tests, which can be usefully applied to medium sized data sets. Next, we propose simulated annealing heuristics, which allow for efficient testing of the collective model in the case of large data sets. We illustrate our methods by a number of computational experiments based on Dutch labor supply data. [less ▲]

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See detailLa décharge du débiteur après transfert, sous autorité de justice, de la totalité de son entreprise : les conditions et la procédure en questions
Pasteger, David ULg; Vandenbulke, Antoine ULg

in Revue de Droit Commercial Belge = Tijdschrift voor Belgisch Handelsrecht (2016), 9

Comment of the judgment of the Commercial Court of Ghent (Oudenaarde section), October 1st 2015, concerning the discharge of a debtor whose business has been fully transferred on the basis of Article 67 ... [more ▼]

Comment of the judgment of the Commercial Court of Ghent (Oudenaarde section), October 1st 2015, concerning the discharge of a debtor whose business has been fully transferred on the basis of Article 67 of the Law on Business Continuity (LBC), excluding the extraordinary debts in the moratorium secured by a mortgage on the family home. The paper then explains in detail the conditions of the discharge provided under Article 70 LBC and compares it with the similar mechanism of the bankrupt's excusability. [less ▲]

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See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2016), 18(11), 1609-1678

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See detailA scanning Hall probe microscope for high resolution, large area, variable height magnetic field imaging
Shaw, Gorky ULg; Kramer, R. B. G.; Dempsey, N. M. et al

in Review of Scientific Instruments (2016), 87(11),

We present a scanning Hall probe microscope operating in ambient conditions. One of the unique features of this microscope is the use of the same stepper motors for both sample positioning as well as ... [more ▼]

We present a scanning Hall probe microscope operating in ambient conditions. One of the unique features of this microscope is the use of the same stepper motors for both sample positioning as well as scanning, which makes it possible to have a large scan range (few mm) in the x and y directions, with a scan resolution of 0.1 μm. Protocols have been implemented to enable scanning at different heights from the sample surface. The z range is 35 mm. Microstructured Hall probes of size 1-5 μm have been developed. A minimum probe-sample distance <2 μm has been obtained by the combination of new Hall probes and probe-sample distance regulation using a tuning fork based force detection technique. The system is also capable of recording local B(z) profiles. We discuss the application of the microscope for the study of micro-magnet arrays being developed for applications in micro-systems. [less ▲]

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See detailRecension de l'ouvrage de G. Rosoux : Vers une "dématérialisation" des droits fondamentaux?
Bouhon, Frédéric ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016), 2016(3), 631-633

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See detailNumerical modeling of coupled thermal-hydro-mechanical behavior of GMZ bentonite in the China-Mock-up test
Zhao, Jingbo; Chen, Liang; Collin, Frédéric ULg et al

in Engineering Geology (2016), 214

Gaomiaozi (GMZ) bentonite is currently considered as themost suitable buffermaterial for high-level radioactive waste geological repository in China. To investigate the long-term performance of GMZ ... [more ▼]

Gaomiaozi (GMZ) bentonite is currently considered as themost suitable buffermaterial for high-level radioactive waste geological repository in China. To investigate the long-term performance of GMZ bentonite under repository conditions, a large scale mock-up test has been carried out since 2011. In the test, a hydration systemand an electrical heater were employed to simulate the Thermal-Hydro-Mechanical (THM) coupled conditions near a repository. In this work, a numerical study is performed to reproduce the experimental data obtained in the first three years of the China-Mock-up experiment. The principle THM characteristics and parameters of the bentonite are presented. On this basis, a THM coupled constitutive model is introduced. With the proposed model, numerical simulations of the China-Mock-up test are carried out using LAGAMINE. The numerical data of temperature, relative humidity, and swelling pressure of the GMZ compacted bentonite are compared with the experimental ones.We discuss the effect of the balance between the drying effect and water penetration process on the THM behavior of the GMZ bentonite. The good agreement between the predicted and experimental results suggests that the proposed model can reproduce the fundamental behavior of GMZ compacted bentonite under coupled THM conditions. [less ▲]

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See detailAre there biologic factors of good prognosis after a platelet rich plasma (PRP) injection for tendinopathies ?
Libertiaux, Vincent ULg; Sancerne, Audrey; LE GOFF, Caroline ULg et al

in Journal of Exercise, Sports & Orthopedics (2016), 3(2), 1-4

Background : The aims of this study were to evaluate the effect of a single PRP injection followed by a standardized reeducation protocol among patients suffering from different tendinopathies, but ... [more ▼]

Background : The aims of this study were to evaluate the effect of a single PRP injection followed by a standardized reeducation protocol among patients suffering from different tendinopathies, but otherwise healthy, and to determine the biomarkers that constitute good prognosis factors, if any. Methods : 48 patients suffering from different tendinopathies and refractory to conventional physiotherapy were treated with a single PRP injection. Prior to the injection, a blood sample was drawn and some biological parameters (glycemia, cholesterolemia,...) were measured. A pain assessment was then made using a Visual Analog Scale of pain (VAS) and a pressure algometer. The same assessment was carried out after 6 weeks and 12 weeks when possible. Results : There is an overall significant improvement in VAS score at the end of the 12 weeks follow- up. However, no correlation was found between the evolution of the clinical scores and the biological parameters measured. Conclusion: A PRP injection followed by a program of eccentric rehabilitation positively affects the algo-functional scores of patients with tendinopathies who were refractory to conventional physio- therapy, whatever the initial values of the measuured biological parameters. [less ▲]

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See detailDroit des discriminations dans l’emploi et le travail, M. MINÉ, Larcier, 2016, 852 pages
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (37), 1783

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See detailA method for measuring the sensitivity of building structural members to fire decay phases
Gernay, Thomas ULg

in Acta Polytechnica (2016), 56(4), 344-352

Fire brigades face a major threat when intervening in a building in fire: the possibility of structural collapse during the cooling phase of the fire, or soon thereafter. Currently this threat is ... [more ▼]

Fire brigades face a major threat when intervening in a building in fire: the possibility of structural collapse during the cooling phase of the fire, or soon thereafter. Currently this threat is amplified by the fact that the behaviour of structures after the time of peak gas temperature is not well understood, and is not taken into account in the design. This work presents an analysis of the behaviour of different structural members under natural fires and develops a method to characterize their sensitivity to fire decay phases. Thermo-mechanical numerical simulations based on the non-linear finite element method are conducted using the parametric fire model of Eurocode to represent natural fires. Results show that, for all the studied members (column, beam) and materials (reinforced concrete, steel and timber), structural failure during or after the cooling phase of a fire is a possible event. The major factors that promote delayed structural failure are the thermal inertia and the constituting material of the member. A method, based on a new indicator, is proposed to quantify the propensity to delayed failure for structural members under natural fire. This work enhances the understanding of the structural behaviour under natural fires and has important implications for the safety of the fire brigades and people proceeding to a building inspection after a fire. [less ▲]

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See detailÀ la recherche d’un monde perdu
Melice, Anne ULg

in Centre Franco Basaglia – Liège, Mouvement pour une psychiatrie démocratique dans le milieu de vie (2016)

Entrer en conversation avec les stagiaires des ateliers de l’asbl Article 23, c’est entendre l’expression aiguë de manques de reconnaissance et de pertes de soi. C’est aussi rencontrer les effets de ... [more ▼]

Entrer en conversation avec les stagiaires des ateliers de l’asbl Article 23, c’est entendre l’expression aiguë de manques de reconnaissance et de pertes de soi. C’est aussi rencontrer les effets de l’image défaite d’eux-mêmes que le monde du dehors leur a renvoyée et qu’ils ont intériorisée. Dans mon texte suivant intitulé « Un monde retrouvé ? », je considérerai les modes de reconnaissance que j’ai observés au cœur des ateliers. [less ▲]

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See detailMeasurements of reference ISO nozzles by high-speed imaging
De Cock, Nicolas ULg; Massinon, Mathieu ULg; Nuyttens, David et al

in Crop Protection (2016), 89

Agricultural spray characteristics determine the efficiency of a pesticide application because size and velocity affect droplet trajectory and impact behavior. At present, the relevance of different ... [more ▼]

Agricultural spray characteristics determine the efficiency of a pesticide application because size and velocity affect droplet trajectory and impact behavior. At present, the relevance of different characterization techniques remains controversial since discrepancies may be significant between measurements performed in different laboratories. A digital image acquisition technique and analysis algorithm is proposed for droplet size and velocimetry measurements as an alternative to well-established techniques such as the Phase Doppler Particle Analyzer (PDPA) or laser diffraction spectrometry (LDS). The algorithm requires double exposed shadow images acquired in a back-lighted arrangement with a Particle Image Velocimetry (PIV) camera and a pulsed light emitting diode (LED). Spatial illumination heterogeneities are corrected by subtracting from each image a mean background acquired on several images without any particle. The algorithm accuracy is ensured by the rejection of out-of-focus particles using a focus parameter depending on gradient intensity at the particle edges. Thresholds for focus particle selection were determined by studying the evolution of the focus parameter and the error on particle size measurements from images containing droplets with uniform size at various distance of the object plane. Selected droplets were identified on both pairs of images to determine their size and velocity. Droplet size distributions were corrected to account for the uneven sampling probability caused by the volumetric method. Droplet size distributions of a set of reference nozzle/pressure combinations defined in the ISO/DIS 25358 were measured. The image technique was able to distinguish each of the reference sprays well. Comparison with PDPA measurements showed that the imaging technique tends to measure an equivalent Dv50, a lower Dv10 and a higher Dv90 leading therefore to a higher relative span factor. Velocity measurements showed good agreement between both techniques except for one nozzle/pressure combination. [less ▲]

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See detailNonlinear dynamical tunneling of optical whispering gallery modes in the presence of a Kerr nonlinearity
Shim, Jeong -Bo ULg; Schlagheck, Peter ULg; Hentschel, Martina et al

in Physical Review A (2016), 94

The effect of a Kerr nonlinearity on dynamical tunneling is studied, using coupled whispering gallery modes in an optical microcavity. The model system that we have chosen is the “add-drop filter,” which ... [more ▼]

The effect of a Kerr nonlinearity on dynamical tunneling is studied, using coupled whispering gallery modes in an optical microcavity. The model system that we have chosen is the “add-drop filter,” which is comprised of an optical microcavity and two waveguides coupled to the cavity. Due to the evanescent fields scattering on the waveguide, the whispering gallery modes in the microcavity form doublets, which manifest themselves as splittings in the spectrum. As these doublets can be regarded as a spectral feature of dynamical tunneling between two different dynamical states with a spatial overlap, the effect of a Kerr nonlinearity on the doublets is numerically investigated in the more general context of the relationship between cubic nonlinearity and dynamical tunneling. Within the numerical realization of the model system, it is observed that the doublets show a bistable transition in their transmission curve as the Kerr nonlinearity in the cavity is increased. At the same time, one rotational mode becomes dominant over the other one in the transmission, since the two states in the doublet have uneven linewidths. By using coupled-mode theory, the underlying mode dynamics of the phenomena is theoretically modeled and clarified. [less ▲]

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See detailTransition to democracy in Tunisia. Learning about citizenship in a national and transnational context
Nachi, Mohamed ULg

in Social Sciences Information = Information sur les Sciences Sociales (2016), 55(4),

La transition en Tunisie a constitué un moment fort d'apprentissage de la démocratie.

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See detailThe construction of religion as a ‘public problem’. The emergence of Islam in the public space during Tunisia’s transition to democracy (2011--2014)
Nachi, Mohamed ULg

in Social Sciences Information = Information sur les Sciences Sociales (2016), 55(4),

La construction de l'islam en "problème public" au cours de la période de transition démocratique.

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See detailLe contrat de travail et la prescription : cas particuliers
Cordier, Quentin ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016)

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See detailBreaking Barriers Between Arts: Bob Dylan’s Nobel Prize
Lombard, David ULg

in Culture, le Magazine Culturel de l'Université de Liège (2016), (10),

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See detailHybridation, intergénéricité et ironie dans “Arsène Schrauwen” d’Olivier Schrauwen
Crucifix, Benoît ULg; Meesters, Gert

in Neuvième art 2.0. (2016)

« La vraie vie, c’est ce qui se passe dans la tête quand on fait la vaisselle », ou « J’ai souvent une idée [de ce à quoi ressemblera ma prochaine histoire], mais généralement mon subconscient a d’autres ... [more ▼]

« La vraie vie, c’est ce qui se passe dans la tête quand on fait la vaisselle », ou « J’ai souvent une idée [de ce à quoi ressemblera ma prochaine histoire], mais généralement mon subconscient a d’autres projets ». Ces citations, tirées d’un récent entretien, sont typiques de la posture d’Olivier Schrauwen et indiquent directement qu’une histoire sur le Congo belge, dans ses mains, ressemblera à toute autre chose que les récits (post)coloniaux auxquels la bande dessinée s’est habituée. Paru en français en 2015 à L’Association, Arsène Schrauwen fait le récit halluciné du voyage au Congo qu’aurait effectué, comme le titre semble l’induire, le grand-père de l’auteur. En partant d’un contexte de production où la bande dessinée documentaire et autobiographique sont désormais bien ancrés, nous nous pencherons sur la façon dont Arsène Schrauwen se distingue de telles approches, souvent par l’absurde et l’ironie, mais aussi en invoquant des thèmes et motifs typiques des genres populaires qui ont dominés l’histoire de la bande dessinée. L’ouvrage de Schrauwen revendique ainsi une portée auto-réflexive qui s’étend d’autant plus à une réflexion comique sur le « langage » de la bande dessinée, un jeu qui sert le propos du livre à des fins plus profondes qu’il ne pourrait paraître. [less ▲]

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See detailM. MINÉ, Droit des discriminations dans l'emploi et le travail
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), (37), 1783

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See detailUn monde retrouvé ?
Melice, Anne ULg

in Centre Franco Basaglia – Liège, Mouvement pour une psychiatrie démocratique dans le milieu de vie (2016)

Vivre au cœur des ateliers d’Article 23, c’est éprouver que la reconnaissance en constitue l’un des enjeux fondamentaux. Dans le sillage de mon texte précédent intitulé « À la recherche d’un monde perdu » ... [more ▼]

Vivre au cœur des ateliers d’Article 23, c’est éprouver que la reconnaissance en constitue l’un des enjeux fondamentaux. Dans le sillage de mon texte précédent intitulé « À la recherche d’un monde perdu », je dessine et analyse ici les modes reconnaissance que j’ai observés au sein des ateliers d’Article 23, et je tente d’en mesurer la portée. Mais j’en interroge aussi les limites éventuelles au-dehors. [less ▲]

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See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 50(5), 1-88

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See detailCarbon Supply and Photoacclimation Cross Talk in the Green Alga Chlamydomonas reinhardtii.
Polukhina, I; Fristedt, R; Dinc, E et al

in Plant Physiology (2016), 172(3), 1494-1505

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See detailPolyhydroxyurethane hydrogels: synthesis and characterizations
Gennen, Sandro ULg; Grignard, Bruno ULg; Thomassin, Jean-Michel ULg et al

in European Polymer Journal (2016), 84

Hydrogels based on polyurethane (PU) are promising (bio-) materials because of their bio- compatibility, biodegradation and excellent mechanical properties. In this publication, polyurethane hydrogels ... [more ▼]

Hydrogels based on polyurethane (PU) are promising (bio-) materials because of their bio- compatibility, biodegradation and excellent mechanical properties. In this publication, polyurethane hydrogels were produced for the first time by a non-isocyanate route by solvent-free step-growth copolymerization between a CO2-sourced hydrophilic polyethy- lene glycol bi-cyclic carbonate with diamines in the presence of a cross-linker. Kinetic of poly(hydroxyurethane) (PHU) synthesis was monitored by ATR-IR and the chemical cross-linking was confirmed by rheology and gel contents measurements. Hydrogels were obtained by immersion of PHUs in water and the influence of the diamine/cross-linker ratio and the nature of diamine on the water swelling and compression properties (compression modulus, strain and stress at break) of PHU hydrogels was evaluated. Additionally, the compression properties of the hydrogels were improved by the addition of Montmorillonite as nanofiller in the PHU formulation. This work opens new application fields for CO2-sourced PHUs. [less ▲]

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See detailEtude transfrontalière des besoins de formation en Education Thérapeutique du Patient souffrant de diabète et/ou d’obésité pour le personnel médical et paramédical : enquête par méthode du groupe nominal
Pétré, Benoît ULg; Ketterer, Frédéric ULg; Vanmeerbeek, Marc ULg et al

in Presse Médicale (2016), 45(10), 351-361

INTRODUCTION: The design of continuous training programs in therapeutic patient education (ETP) should be inspired by needs shown by the professionals concerned in terms of mobilization or acquisition of ... [more ▼]

INTRODUCTION: The design of continuous training programs in therapeutic patient education (ETP) should be inspired by needs shown by the professionals concerned in terms of mobilization or acquisition of skills in this domain. The objective of this study is to analyze needs expressed by healthcare professionals (HP) involved in patients' management presenting a type 2 diabetes (T2D) and/or obesity and to compare them with the existing recommendations. METHODS: One hundred and five PS (general practitioners, dietitians and nurses) of 3 frontier regions of French-speaking European countries (France, Belgium and Grand duchy of Luxembourg) were questioned in 12 monodisciplinary groups according to the technique of the nominal group. Needs expressed by the participants were classified in the categories of the reference table of skills to dispense TPE (National Institute for Health Prevention and Education [INPES], 2013). RESULTS/DISCUSSION: Among needs expressed by HP, 52 % of the votes targeted relational skills, 10 % of the skills relative to the biomedical techniques, 20 % of the skills relative to the educational techniques and 11 %, those of organization and the coordination. Seven percent of the proposals were out of the categories of the INPES. Results do not allow to establish profiles of skills according to the studied region or profession. The recognition of the TPE by the French legislation does not seem to influence in a major way the data. CONCLUSION: The needs expressed by PS in the context of this study are focused on the relation HP/patient that is the heart of the TPE. It would however be necessary to raise awareness among HP in the acquisition of the other skills which concern in particular the animation of group, the interprofessional coordination, the consideration of the environment or more generally the procedures. [less ▲]

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See detailLa reconnaissance internationale de la République du Kosovo (2008-2016) : succès, défis et perspectives de ce nouvel État
Lika, Liridon ULg

in Revue de la Faculté de Droit de l'Université de Liège (2016)

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See detailResting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers
BONHOMME, Vincent ULg; VANHAUDENHUYSE, Audrey ULg; Demertzi, Athina ULg et al

in Anesthesiology (2016), 125(5), 873-878

Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control ... [more ▼]

Background: Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing psychedelic dreaming and no apparent interaction with the environment. The authors used functional magnetic resonance imaging to explore ketamine-induced changes in RSNs connectivity. Methods: Fourteen healthy volunteers received stepwise intravenous infusions of ketamine up to loss of responsiveness. Because of agitation, data from six subjects were excluded from analysis. RSNs connectivity was compared between absence of ketamine (wake state [W1]), light ketamine sedation, and ketamine-induced unresponsiveness (deep sedation [S2]). Results: Increasing the depth of ketamine sedation from W1 to S2 altered DMn and SALn connectivity and suppressed the anticorrelated activity between DMn and other brain regions. During S2, DMn connectivity, particularly between the medial prefrontal cortex and the remaining network (effect size β [95% CI]: W1 = 0.20 [0.18 to 0.22]; S2 = 0.07 [0.04 to 0.09]), and DMn anticorrelated activity (e.g., right sensory cortex: W1 = −0.07 [−0.09 to −0.04]; S2 = 0.04 [0.01 to 0.06]) were broken down. SALn connectivity was nonuniformly suppressed (e.g., left parietal operculum: W1 = 0.08 [0.06 to 0.09]; S2 = 0.05 [0.02 to 0.07]). Executive control networks, auditory network, SMn, and visual network were minimally affected. Conclusions: Ketamine induces specific changes in connectivity within and between RSNs. Breakdown of frontoparietal DMn connectivity and DMn anticorrelation and sensory and SMn connectivity preservation are common to ketamine and propofol-induced alterations of consciousness. [less ▲]

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See detailEvaluation of different in vitro dissolution tests based on level A in vitro–in vivo correlations for fenofibrate self-emulsifying lipid-based formulations
Pestieau, Aude ULg; Lebrun, Sonia; Cahay, Bernard et al

in European Journal of Pharmaceutics & Biopharmaceutics (2016)

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See detailExtraction Socket Management with Buccal Plate Expansion: Preliminary Results of a Novel Technique
Fernandez Ayora, Alberto; González-Martín, Oscar; ROMPEN, Eric ULg et al

in International Journal of Periodontics & Restorative Dentistry (2016), 36(6),

The primary objective of this pilot study was to evaluate a new socket preservation technique involving the intentional expansion of the extraction socket buccal plate using a flapless internal ... [more ▼]

The primary objective of this pilot study was to evaluate a new socket preservation technique involving the intentional expansion of the extraction socket buccal plate using a flapless internal corticotomy and biomaterials. A total of 11 patients requiring tooth extraction were enrolled in this study. The aim of this technique was to maintain or improve the hard and soft tissue contour of the ridge after tooth extraction. All surgical sites healed uneventfully. Significant alveolar bone dimension changes were observed in the coronal region of the ridge (-1.4 ± 0.9 mm); however, it was only slightly lower at the medium (-0.35 ± 0.7 mm) and apical levels (-0.3 ± 0.8 mm) (P > .05). The ridge dimensional changes were significantly higher in the buccal aspect than in the palatal aspect in all patients. Vertical bone resorption was not significant. Concerning the soft tissue contour, the horizontal distance between the preoperative and postoperative buccal profiles ranged from 0.94 to -2.88 mm. The proposed ridge preservation technique may help maintain the volume of the healed ridge but cannot completely prevent contour changes after tooth extraction. [less ▲]

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See detailUse of long bolts for beam-to-concrete-filled rectangular hollow section column joints in seismic-resistant frames
Hoang, Van Long; Jaspart, Jean-Pierre ULg; Demonceau, Jean-François ULg

in Steel Construction (2016), 9(4), 305-314

A research on a specific type of unstiffened extended end-plate joint used to connect I-shaped beams to concrete-filled rectangular hollow section columns is presented in this paper. The main idea is to ... [more ▼]

A research on a specific type of unstiffened extended end-plate joint used to connect I-shaped beams to concrete-filled rectangular hollow section columns is presented in this paper. The main idea is to use long bolts throughout the column to connect the beam end-plates, so: (1) avoiding intermediate connecting elements (e.g. a reverse U channel) or special bolts (e.g. blind bolts) that are sometimes used in practice; (2) improving the resistance and stiffness of the joint to be used in seismic resistant frames. Firstly, a test program has been performed within a RFCS European project entitled HSS-SERF “High Strength Steel in Seismic Resistant Building Frames”, 2009-2013. In the test program, specimens subjected to significant bending moments (and shear) or to shear only have been defined. Then, analytical models based on the component approach and aimed at predicting the joint response have been proposed; their validity is demonstrated through comparisons with the test results. Finally, the requirements of EN-1998-1-1 related to full strength resistance for the proposed joint configuration are discussed, accounting for the actual position of plastic hinges and the possible individual over-strength factors for each component. [less ▲]

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See detailAvoir faim au risque d'en mourir ? Le paradoxe de l'anorexie mentale.
Triffaux, Jean-Marc ULg; Moukhaiber, sophie; PIETTE, Catherine ULg

in Revue Médicale de Liège (2016), 71(11), 495-501

Anorexia nervosa is a complex pathology that regularly leads clinicians to a therapeutic impasse. The origin of this disorder is multifactorial. It occurs most often in adolescence and affects mainly ... [more ▼]

Anorexia nervosa is a complex pathology that regularly leads clinicians to a therapeutic impasse. The origin of this disorder is multifactorial. It occurs most often in adolescence and affects mainly women. Paradoxically, hunger is present but dissociated from adequate food function. Somatic and psychological impact can be particularly heavy. The treatment is difficult and requires a multidisciplinary care. An eclectic and integrative approach, moving away from rigid therapeutic methods and integrating the plurality of techniques, seems to be particularly recommended to increase the chances of therapeutic success. This article summarizes the various theoretical models of anorexia nervosa and its modalities of treatment. [less ▲]

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See detailResults From Belgium’s 2016 Report Card on Physical Activity for Children and Youth
Wijtzes, Anne I; Verloigne, Maïté; Mouton, Alexandre ULg et al

in Journal of Physical Activity and Health (2016), 13((Suppl 2)), 95-103

This 2016 Belgium Report Card on Physical Activity for Children and Youth is the first systematic evaluation of physical activity (PA) behaviors, related health behaviors, health outcomes, and influences ... [more ▼]

This 2016 Belgium Report Card on Physical Activity for Children and Youth is the first systematic evaluation of physical activity (PA) behaviors, related health behaviors, health outcomes, and influences thereon, using the Active Healthy Kids Canada grading framework. A research working group consisting of PA experts from both Flanders and Wallonia collaborated to determine the indicators to be graded, data sources to be used, and factors to be taken into account during the grading process. Grades were finalized after consensus was reached among the research working group and 2 stakeholder groups consisting of academic and policy experts in the fields of PA, sedentary behavior, and dietary behavior. Eleven indicators were selected and assigned the following grades: Overall PA (F+), Organized Sport Participation (C-), Active Play (C+), Active Transportation (C-), Sedentary Behaviors (D-), School (B-), Government Strategies and Investment (C+), and Weight Status (D). Incomplete grades were assigned to Family and Peers, Community and the Built Environment, and Dietary Behaviors due to a lack of nationally representative data. In conclusion, despite moderately positive social and environmental influences, PA levels of Belgian children and youth are low while levels of sedentary behaviors are high. [less ▲]

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See detailIncidence and Phenotype at Diagnosis of Very-early-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease: A Population-based Study [1988-2011].
Bequet, Emeline ULg; Sarter, Hélène; Fumery, Mathurin et al

in Journal of Crohn's and Colitis [=JCC] (2016)

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See detailA Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo
Hendricks, Céline; Dubail, Johanne; Brohée, Laura ULg et al

in PLoS ONE (2016)

Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins. It is involved in axonal ... [more ▼]

Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins. It is involved in axonal development, angiogenesis and cancer progression. Its primary mRNA is subjected to alternative splicing mechanisms generating different isoforms, some of which lack the transmembrane domain and display antagonist properties to NRP1 full size (FS). NRP1 is further post-translationally modified by the addition of glycosaminoglycans (GAG) side chains through an O-glycosylation site at serine612. Here, we characterized a novel splice variant which has never been investigated, NRP1-Δ7, differing from the NRP1-FS by a deletion of 7 amino acids occurring two residues downstream of the O-glycosylation site. This short sequence contains two aspartic residues critical for efficient glycosylation. As expected, the high molecular weight products appearing as a smear in SDS-PAGE and reflecting the presence of GAG in NRP1-FS were undetectable in the NRP1-Δ7 protein. NRP1-Δ7 mRNA was found expressed at an appreciable level, between 10 and 30% of the total NRP1, by various cells lines and tissues from human and murine origin. To investigate the biological properties of this isoform, we generated prostatic (PC3) and breast (MDA-MB-231) cancer cells able to express recombinant NRP1-FS or NRP1-Δ7 in a doxycycline-inducible manner. Cells with increased expression of NRP1-Δ7 were characterized in vitro by a significant reduction of proliferation, migration and anchorage-independent growth, while NRP1-FS had the expected opposite “pro-tumoral” effects. Upon VEGF-A165 treatment, a lower internalization rate was observed for NRP1-Δ7 than for NRP1-FS. Finally, we showed that NRP1-Δ7 inhibited growth of prostatic tumors and their vascularization in vivo. This report identifies NRP1-Δ7 as a splice variant displaying anti-tumorigenic properties in vitro and in vivo, emphasizing the need to consider this isoform in future studies. [less ▲]

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See detailLacunes extrinsèques et effets au contentieux préjudiciel : lorsque la Cour de cassation fait d'une pierre deux coups
Pironnet, Quentin ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2016), 35(2016), 1652-1658

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See detailEffects of interactions on the relaxation processes in magnetic nanostructures
Atkinson, Lewis; Ostler, Thomas ULg; Ondrej, Hovorka et al

in Physical Review. B: Condensed Matter and Materials Physics (2016), 94

Controlling the relaxation of magnetization in magnetic nanostructures is key to optimizing magnetic storage device performance. This relaxation is governed by both intrinsic and extrinsic relaxation ... [more ▼]

Controlling the relaxation of magnetization in magnetic nanostructures is key to optimizing magnetic storage device performance. This relaxation is governed by both intrinsic and extrinsic relaxation mechanisms and with the latter strongly dependent on the interactions between the nanostructures. In the present work we investigate laser induced magnetization dynamics in a broadband optical resonance type experiment revealing the role of interactions between nanostructures on the relaxation processes of granular magnetic structures. The results are corroborated by constructing a temperature dependent numerical micromagnetic model of magnetization dynamics based on the Landau-Lifshitz-Bloch equation. The model predicts a strong dependence of damping on the key material properties of coupled granular nanostructures in good agreement with the experimental data. We show that the intergranular, magnetostatic and exchange interactions provide a large extrinsic contribution to the damping. Finally we show that the mechanism can be attributed to an increase in spin-wave degeneracy with the ferromagnetic resonance mode as revealed by semianalytical spin-wave calculations. [less ▲]

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See detailBollywood et les limites du soft power indien
Vlassis, Antonios ULg

in Telos (electronic journal) (2016)

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See detailCompetition between finite-size effects and dipole–dipole interactions in few-atom systems
Damanet, François ULg; Martin, John ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (2016), 49

In this paper, we study the competition between finite-size effects (i.e. discernibility of particles) and dipole–dipole interactions in few-atom systems coupled to the electromagnetic field in vacuum. We ... [more ▼]

In this paper, we study the competition between finite-size effects (i.e. discernibility of particles) and dipole–dipole interactions in few-atom systems coupled to the electromagnetic field in vacuum. We consider two hallmarks of cooperative effects, superradiance and subradiance, and compute for each the rate of energy radiated by the atoms and the coherence of the atomic state during the time evolution. We adopt a statistical approach in order to extract the typical behaviour of the atomic dynamics and average over random atomic distributions in spherical containers with prescribed k0 R with k0 the radiation wavenumber and R the average interatomic distance. Our approach allows us to highlight the tradeoff between finite-size effects and dipole– dipole interactions in superradiance/subradiance. In particular, we show the existence of an optimal value of k0R for which the superradiant intensity and coherence pulses are the less affected by dephasing effects induced by dipole–dipole interactions and finite-size effects. [less ▲]

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See detailA near-infrared interferometric survey of debris-disc stars. V. PIONIER search for variability
Ertel, S.; Defrere, Denis ULg; Absil, Olivier ULg et al

in Astronomy and Astrophysics (2016), 595

Context. Extended circumstellar emission has been detected within a few 100 milli-arcsec around ≳10% of nearby main sequence stars using near-infrared interferometry. Follow-up observations using other ... [more ▼]

Context. Extended circumstellar emission has been detected within a few 100 milli-arcsec around ≳10% of nearby main sequence stars using near-infrared interferometry. Follow-up observations using other techniques, should they yield similar results or non-detections, can provide strong constraints on the origin of the emission. They can also reveal the variability of the phenomenon. Aims: We aim to demonstrate the persistence of the phenomenon over the timescale of a few years and to search for variability of our previously detected excesses. Methods: Using Very Large Telescope Interferometer (VLTI)/Precision Integrated Optics Near Infrared ExpeRiment (PIONIER) in H band we have carried out multi-epoch observations of the stars for which a near-infrared excess was previously detected using the same observation technique and instrument. The detection rates and distribution of the excesses from our original survey and the follow-up observations are compared statistically. A search for variability of the excesses in our time series is carried out based on the level of the broadband excesses. Results: In 12 of 16 follow-up observations, an excess is re-detected with a significance of > 2σ, and in 7 of 16 follow-up observations significant excess (> 3σ) is re-detected. We statistically demonstrate with very high confidence that the phenomenon persists for the majority of the systems. We also present the first detection of potential variability in two sources. Conclusions: We conclude that the phenomenon responsible for the excesses persists over the timescale of a few years for the majority of the systems. However, we also find that variability intrinsic to a target can cause it to have no significant excess at the time of a specific observation. [less ▲]

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See detailIn-utero coxsackievirus B4 infection of the mouse thymus
Jaïdane, Hela; Halouani, Aymen; Jmii, H. et al

in Clinical & Experimental Immunology (2016), Sous presse

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes ... [more ▼]

Type B coxsackievirus (CV-B) infections are involved frequently in the triggering of several autoimmune diseases such as myocarditis, dilated cardiomyopathy, pericarditis, pancreatitis, type 1 diabetes, encephalitis, thyroiditis or Sjo€gren’s syndrome. Serological and virological evidence suggests that maternal infections during pregnancy can play a role in the appearance of these diseases in offspring. The current study aims to explore the effect of an in-utero CV-B infection on the fetal thymus, the central site for programming immunological self-tolerance. In this perspective, female Swiss albino mice were inoculated intraperitoneally or orally with the diabetogenic CV-B4 E2 strain at gestational days 10 or 17. Offspring were killed at different post-inoculation times, and their thymuses were analysed for evidence of infection and alterations in thymic T cell subsets. In-utero CV-B infection of the thymus was demonstrated during the course of vertical transmission, as attested by viral RNA and infectious virus detection in most analysed samples. No histopathological changes were evident. Thymic T cells were not depleted, despite being positive for viral RNA. As evidenced by flow cytometry analysis, CV-B infection of the fetal thymus induced significant changes of thymic T cell populations, particularly with maternal inoculation at gestational day 10. Altogether, these findings suggest that CV-B infection of the fetal thymus may play an important role in the genesis of autoimmune diseases. [less ▲]

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See detailInterspecific variation of warning calls in piranhas: a comparative analysis
Melotte, Geoffrey ULg; Vigouroux, Régis; Michel, Christian ULg et al

in Scientific Reports (2016)

Fish sounds are known to be species-specific, possessing unique temporal and spectral features. We have recorded and compared sounds in eight piranha species to evaluate the potential role of acoustic ... [more ▼]

Fish sounds are known to be species-specific, possessing unique temporal and spectral features. We have recorded and compared sounds in eight piranha species to evaluate the potential role of acoustic communication as a driving force in clade diversification. All piranha species showed the same kind of sound-producing mechanism: sonic muscles originate on vertebrae and attach to a tendon surrounding the bladder ventrally. Contractions of the sound-producing muscles force swimbladder vibration and dictate the fundamental frequency. It results the calling features of the eight piranha species logically share many common characteristics. In all the species, the calls are harmonic sounds composed of multiple continuous cycles. However, the sounds of Serrasalmus elongatus (higher number of cycles and high fundamental frequency) and S. manueli (long cycle periods and low fundamental frequency) are clearly distinguishable from the other species. The sonic mechanism being largely conserved throughout piranha evolution, acoustic communication can hardly be considered as the main driving force in the diversification process. However, sounds of some species are clearly distinguishable despite the short space for variations supporting the need for specific communication. Behavioural studies are needed to clearly understand the eventual role of the calls during spawning events. [less ▲]

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See detailSurface- and redox-active multifunctional polyphenol-derived poly(ionic liquid)s: controlled synthesis and characterization
Patil, Nagaraj ULg; Cordella, Daniela; Aqil, Abdelhafid ULg et al

in Macromolecules (2016), 49(20), 7676-7691

Combining the redox activity and remarkable adhesion propensity of polyphenols (such as catechol or pyrogallol) with the numerous tunable properties of poly(ionic liquid)s (PILs) is an attractive route to ... [more ▼]

Combining the redox activity and remarkable adhesion propensity of polyphenols (such as catechol or pyrogallol) with the numerous tunable properties of poly(ionic liquid)s (PILs) is an attractive route to design inventive multifunctional macro-molecular platforms. In this contribution, we describe the first synthesis of a novel family of structurally well-defined PILs functionalized with catechol/pyrogallol/phenol pendants by organometallic-mediated radical polymerization (OMRP) using an alkyl−cobalt(III) complex as initiator and mediating agent. The living character of the chains is also exploited to produce di-and triblock PILs, and the facile counteranion exchange reactions afforded a library of PILs-bearing free phenol/catechol/pyrogallol moieties. Electrochemical investigations of catechol/pyrogallol-derived PILs in aqueous medium demonstrated the characteristic catechol to o-quinone transformations, whereas, quasi-reversible doping/undoping with supporting electrolyte cations (Li + /tetrabutylammonium +) has been observed in organic media, suggesting a bright future for this new family of redox-active PILs as cathode material for secondary energy storage devices. Also, pendant catechol/pyrogallol groups mediated sustained anchoring onto the gold surface conferred PILs properties to the interface. As a proof-of-concept, both the adsorption and inhibition of proteins on polymer modified surfaces have been demonstrated in real time using the quartz crystal microbalance with dissipation technique. The exquisite physicochemical tunability of these innovative surface-and redox-active PILs makes them excellent candidates for a broad range of potential applications, including " smart surfaces " and electrochemical energy storage devices. [less ▲]

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See detailVelocimetry of superconducting vortices based on stroboscopic resonances
Jelic, Zeljko ULg; Milosevic, Milorad; Silhanek, Alejandro ULg

in Scientific Reports (2016), 6

An experimental determination of the mean vortex velocity in superconductors mostly relies on the measurement of flux-flow resistance with magnetic field, temperature, or driving current. In the present ... [more ▼]

An experimental determination of the mean vortex velocity in superconductors mostly relies on the measurement of flux-flow resistance with magnetic field, temperature, or driving current. In the present work we introduce a method combining conventional transport measurements and a frequency-tuned flashing pinning potential to obtain reliable estimates of the vortex velocity. The proposed device is characterized using the time-dependent Ginzburg-Landau formalism, where the velocimetry method exploits the resonances in mean vortex dissipation when temporal commensuration occurs between the vortex crossings and the flashing potential. We discuss the sensitivity of the proposed technique on applied current, temperature and heat diffusion, as well as the vortex core deformations during fast motion. [less ▲]

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See detailMyoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer
Blomme, Arnaud; Costanza, Brunella ULg; De Tullio, Pascal ULg et al

in Oncogene (2016)

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as ... [more ▼]

Myoferlin is a multiple C2-domain-containing protein that regulates membrane repair, tyrosine kinase receptor function and endocytosis in myoblasts and endothelial cells. Recently it has been reported as overexpressed in several cancers and shown to contribute to proliferation, migration and invasion of cancer cells. We have previously demonstrated that myoferlin regulates epidermal growth factor receptor activity in breast cancer. In the current study, we report a consistent overexpression of myoferlin in triple-negative breast cancer cells (TNBC) over cells originating from other breast cancer subtypes. Using a combination of proteomics, metabolomics and electron microscopy, we demonstrate that myoferlin depletion results in marked alteration of endosomal system and metabolism. Mechanistically, myoferlin depletion caused impaired vesicle traffic that led to a misbalance of saturated/unsaturated fatty acids. This provoked mitochondrial dysfunction in TNBC cells. As a consequence of the major metabolic stress, TNBC cells rapidly triggered AMP activated protein kinase-mediated metabolic reprogramming to glycolysis. This reduced their ability to balance between oxidative phosphorylation and glycolysis, rendering TNBC cells metabolically inflexible, and more sensitive to metabolic drug targeting in vitro. In line with this, our in vivo findings demonstrated a significantly reduced capacity of myoferlin-deficient TNBC cells to metastasise to lungs. The significance of this observation was further supported by clinical data, showing that TNBC patients whose tumors overexpress myoferlin have worst distant metastasis-free and overall survivals. This novel insight into myoferlin function establishes an important link between vesicle traffic, cancer metabolism and progression, offering new diagnostic and therapeutic concepts to develop treatments for TNBC patients. [less ▲]

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See detailSU(3) Clebsch-Gordan coefficients at large $N_c$
Stancu, Floarea ULg

in Nuclear Physics A (2016), 945

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic ... [more ▼]

It is argued that several papers where SU(3) Clebsch-Gordan coefficients were calculated in order to describe properties of hadronic systems are, up to a phase convention, particular cases of analytic formulae derived by Hecht in 1965 in the context of nuclear physics. This is valid for irreducible representations with multiplicity one in the corresponding Clebsch-Gordan series. For multiplicity two, Hecht has proposed an alternative which can provide correct $1/N_c$ sub-leading orders in large $N_c$ studies. [less ▲]

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See detailImpact of biomaterial microtopography on bone regeneration: comparison of three hydroxyapatites
LAMBERT, France ULg; Bacevic, Miljana ULg; Layrolle, Pierre et al

in Clinical Oral Implants Research (2016)

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite ... [more ▼]

Aims: The primary objective of this study was to compare the in vivo performance, namely in terms of quantity of newly formed bone and bone-to-material contact (osteoconductivity), of three hydroxyapatite-based biomaterials (HA) of different origins (natural or synthetic) or manufacturing process in a sinus lift model in rabbits. The secondary objective was to correlate the findings with the physical and topographical characteristics of the biomaterials. Materials and Methods: Two bovine HA manufactured with different processes (bovine hydroxyapatites [BHA] and cuttlebone hydroxyapatite [CBHA]) and a synthetic hydroxyapatite (SHA) sintered at high temperature were characterised with scanning electronic microscopy (SEM) and the measurement of specific surface area (BET). The materials were implanted in a sinus lift model in rabbits; histological and histomorphometric evaluation using non-decalcified sections was performed at 1, 5 and 12 weeks after implantation. Results: The studied biomaterials displayed a different surface topography. The two natural HA displayed significantly higher bone quantities (P = 0.0017; BHA vs. SHA, P = 0.0018 and CBHA vs. SHA, P = 0.033) at 5 and 12 weeks compared to the synthetic one (SHA). Moreover, the osteoconductivity (bone-to-material contact) was significantly higher in the BHA group compared to the two other groups (P = 0.014; BHA vs. SHA, P = 0.023 and BHA vs. CBHA, P = 0.033). Conclusion: HA-based biomaterials from diverse origins and manufacturing processes displayed different topographical characteristics. This may have influenced different regenerated bone architecture observed; more bone was found with natural HA compared to the synthetic one, and significantly higher bone-to-material contacts were found with BHA. [less ▲]

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See detailBiomasse et stocks de carbone des forêts tropicales africaines (synthèse bibliographique)
Loubota Panzou, Grâce Jopaul ULg; Doucet, Jean-Louis ULg; Loumeto, Jean-Joël et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2016), 20(4), 508-522

Introduction. Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated at ... [more ▼]

Introduction. Quantifying the biomass and carbon stocks contained in tropical forests has become an international priority for the implementation of the REDD+ mechanism. Forest biomass is estimated at three successive levels: the tree, the stand and the region level. This paper reviews the state of the art regarding the estimation of biomass and carbon stocks in tropical African forests. Literature. This review highlights the fact that very few allometric equations, equations used for estimating the biomass of the tree using non-destructive measurements (diameter, height), have been established for tropical African forests. At the stand level, the review highlights the spatial and temporal variations in biomass between forest types in Central and Eastern Africa. While biomass recovery after a disturbance (logging, for instance) is rather quick, a great deal of uncertainty still remains regarding the spatial variation in biomass, and there is no consensus on a regional biomass map. The quality of biomass mapping in tropical Africa strongly depends on the type of remotely-sensed data being used (optical, RADAR or LIDAR), and the allometric equation used to convert forest inventory data into biomass. Conclusions. Based on the lack of precision of the available allometric equations and forest inventory data and the large spatial scale involved, many uncertainties persist in relation to the estimation of the biomass and carbon stocks contained in African tropical forests. [less ▲]

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See detailThe influence of flight style on the aerodynamic properties of avian wings as fixed lifting surfaces
Lees, John J.; Dimitriadis, Grigorios ULg; Nudds, Robert L.

in PeerJ (2016), 4:e2495

The diversity of wing morphologies in birds reflects their variety of flight styles and the associated aerodynamic and inertial requirements. Although the aerodynamics underlying wing morphology can be ... [more ▼]

The diversity of wing morphologies in birds reflects their variety of flight styles and the associated aerodynamic and inertial requirements. Although the aerodynamics underlying wing morphology can be informed by aeronautical research, important differences exist between planes and birds. In particular, birds operate at lower, transitional Reynolds numbers than do most aircraft. To date, few quantitative studies have investigated the aerodynamic performance of avian wings as fixed lifting surfaces and none have focused upon the differences between wings from different flight style groups. Dried wings from 10 bird species representing 3 distinct flight style groups were mounted on a force/torque sensor within a wind tunnel in order to test the hypothesis that wing morphologies associated with different flight styles exhibit different aerodynamic properties. Morphological differences manifested primarily as differences in drag rather than lift. Maximum lift coefficients did not differ between groups, whereas minimum drag coefficients were lowest in undulating flyers (Corvids). The lift to drag ratios were lower than in conventional aerofoils and data from free-flying soaring species; particularly in high frequency, flapping flyers (Anseriformes), which do not rely heavily on glide performance. The results illustrate important aerodynamic differences between the wings of different flight style groups that cannot be explained solely by simple wing-shape measures. Taken at face value, the results also suggest that wing-shape is linked principally to changes in aerodynamic drag, but, of course, it is aerodynamics during flapping and not gliding that is likely to be the primary driver. [less ▲]

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See detailEtest® versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: results from PREMIUM, a European multicentre study.
CANTON, Rafael; LVERMORE, David M; MOROSINI, Maria Isabel et al

in Journal of Antimicrobial Chemotherapy (2016)

OBJECTIVES: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a ... [more ▼]

OBJECTIVES: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a European multicentre study. METHODS: Ceftaroline MICs were determined by reference BMD and by Etest for 1242 MSSA and MRSA isolates collected between February and May 2012 from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour. RESULTS: Overall concordance between BMD and Etest was good, with >97% essential agreement and >95% categorical agreement. Nevertheless, 12 of the 26 MRSA isolates found resistant by BMD scored as susceptible by Etest, with MICs ≤1 mg/L, thus counting as very major errors, whereas only 5 of 380 MRSA isolates found ceftaroline susceptible in BMD were miscategorized as resistant by Etest. Twenty-one of the 26 isolates with MICs of 2 mg/L by BMD were then retested twice by each of three central laboratories: BMD MICs of 2 mg/L were consistently found for 19 of the 21 isolates. Among 147 Etest results for these 21 isolates (original plus six repeats per isolate) 112 were >1 mg/L. CONCLUSIONS: BMD and Etest have good overall agreement for ceftaroline against Staphylococcus aureus; nevertheless, reliable Etest-based discrimination of the minority of ceftaroline-resistant (MIC 2 mg/L) MRSA is extremely challenging, requiring careful reading of strips, ideally with duplicate testing. [less ▲]

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See detailLettuce (Lactuca sativa L. var. Sucrine) Growth Performance in Complemented Aquaponic Solution Outperforms Hydroponics
Delaide, Boris; Goddek, Simon; Gott, James et al

in Water (2016), 8(467),

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See detailThe closure of arteriovenous fistula in kidney transplant recipients is associated with an acceleration of kidney function decline
WEEKERS, Laurent ULg; VANDERWECKENE, Pauline ULg; pottel, hans et al

in Nephrology Dialysis Transplantation (2016)

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney ... [more ▼]

ABSTRACT Background. The creation of arteriovenous fistula (AVF) may retard chronic kidney disease progression in the general population. Conversely, the impact of AVF closure on renal function in kidney transplant recipients (KTRs) remains unknown. Methods. From 2007 to 2013, we retrospectively categorized 285 KTRs into three groups: no AVF (Group 0, n = 90), closed AVF (Group 1, n = 114) and left-open AVF (Group 2, n = 81). AVF closure occurred at 653 ± 441 days after kidney transplantation (KTx), with a thrombosis:ligation ratio of 19:95. Estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Disease equation. Linear mixed models calculated the slope and intercept of eGFR decline versus time, starting at 3 months post-KTx, with a median follow-up of 1807 days (95% confidence interval 1665–2028). Results. The eGFR slope was less in Group 1 (−0.081 mL/min/ month) compared with Group 0 (−0.183 mL/min/month; P = 0.03) or Group 2 (−0.164 mL/min/month; P = 0.09). Still, the eGFR slope significantly deteriorated after (−0.159 mL/min/month) versus before (0.038 mL/min/month) AVF closure (P= 0.03). Study periods before versus after AVF closure were balanced to a mean of 13.5 and 12.5 months, respectively, with at least 10 observations per patient (n = 99). Conclusions. In conclusion, a significant acceleration of eGFR decline is observed over the 12 months following the closure of a functioning AVF in KTRs. [less ▲]

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See detailLe régime disciplinaire appliqué aux internés : irresponsables au pénal, responsables au disciplinaire ?
Michiels, Olivier ULg; Nederlandt, Olivia

in Journal des Tribunaux (2016), (6660), 561-570

La loi de principes du 12 janvier 2005 organise un régime disciplinaire au sein des établissements pénitentiaires avec pour objectif le maintien de l'ordre et de la sécurité. Ce régime s'applique aux ... [more ▼]

La loi de principes du 12 janvier 2005 organise un régime disciplinaire au sein des établissements pénitentiaires avec pour objectif le maintien de l'ordre et de la sécurité. Ce régime s'applique aux internés détenus en prison. Déclarer des internés responsables d'avoir commis des infractions disciplinaires pose cependant question, dès lors que la mesure d'internement signifie qu'ils ont préalablement été déclarés irresponsables de leurs actes. Cet article présente le régime disciplinaire appliqué en prison, en abordant différentes questions relatives aux infractions disciplinaires, portant sur leur nature juridique, leur élément moral et leur imputabilité aux internés. [less ▲]

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See detailHépatite C. Dépister largement...et guérir!
DELWAIDE, Jean ULg

in Le Journal du Médecin (2016), (2467), 20-21

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