References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 601 to 700 of 47200     2 3 4 5 6 7 8 9 10 11 12     An independent SSVEP-based brain-computer interface in locked-in-syndromeLesenfants, Damien ; Habbal, Dina; Lugo et alin Journal of Neural Engineering (2014)OBJECTIVE: Steady-state visually evoked potential (SSVEP)-based brain-computer interfaces (BCIs) allow healthy subjects to communicate. However, their dependence on gaze control prevents their use with ... [more ▼]OBJECTIVE: Steady-state visually evoked potential (SSVEP)-based brain-computer interfaces (BCIs) allow healthy subjects to communicate. However, their dependence on gaze control prevents their use with severely disabled patients. Gaze-independent SSVEP-BCIs have been designed but have shown a drop in accuracy and have not been tested in brain-injured patients. In the present paper, we propose a novel independent SSVEP-BCI based on covert attention with an improved classification rate. We study the influence of feature extraction algorithms and the number of harmonics. Finally, we test online communication on healthy volunteers and patients with locked-in syndrome (LIS). APPROACH: Twenty-four healthy subjects and six LIS patients participated in this study. An independent covert two-class SSVEP paradigm was used with a newly developed portable light emitting diode-based 'interlaced squares' stimulation pattern. MAIN RESULTS: Mean offline and online accuracies on healthy subjects were respectively 85 ± 2% and 74 ± 13%, with eight out of twelve subjects succeeding to communicate efficiently with 80 ± 9% accuracy. Two out of six LIS patients reached an offline accuracy above the chance level, illustrating a response to a command. One out of four LIS patients could communicate online. SIGNIFICANCE: We have demonstrated the feasibility of online communication with a covert SSVEP paradigm that is truly independent of all neuromuscular functions. The potential clinical use of the presented BCI system as a diagnostic (i.e., detecting command-following) and communication tool for severely brain-injured patients will need to be further explored. [less ▲]Detailed reference viewed: 4 (0 ULg) Meandering jets in shallow rectangular reservoirs: POD analysis and identification of coherent structuresPeltier, Yann ; Erpicum, Sébastien ; Archambeau, Pierre et alin Experiments in Fluids (2014), 55The effect of the shallowness on meandering jets in a shallow rectangular reservoir is investigated. Four meandering flows were investigated in an experimental shallow rectangular reservoir. Their ... [more ▼]The effect of the shallowness on meandering jets in a shallow rectangular reservoir is investigated. Four meandering flows were investigated in an experimental shallow rectangular reservoir. Their boundary conditions were chosen to cover a large range of friction numbers (defined with the sudden expansion width). Due to the unsteady characteristics of the flows, a Proper Orthogonal Decomposition of the fluctu-ating part of the surface velocity fields measured using LSPIV was used for discriminating the flow struc-tures responsible for the meandering of the jet. Less than 1 % of the calculated POD modes significantly contribute to the meandering of the jet and two types of instability are in competition in such a flow con-figuration. The sinuous mode is the dominant mode in the flow and it induces the meandering of the flow, while the varicose mode is a source of local mixing and weakly participates to the flow. The fluctuating velocity fields were then reconstructed using the POD modes corresponding to 80% of the total mean fluctuating kinetic energy and the coherent structures were identified using the residual vorticity, their centres being localised using a topology algorithm. The trajectories of the structures centres emphasize that at high friction number the coherent structures are small and laterally paired in the near, middle and far fields of the jet, while with decreasing friction number the structures merge into large horizontal vortices in the far-field of the jet, their trajectories showing more variability in space and time. The analysis of the stability regime finally reveals that the sinuous mode is convectively unstable and may become absolutely unstable at the end of the reservoir when the friction number is small. [less ▲]Detailed reference viewed: 26 (15 ULg) L'affaire Wesphael : Quelques observations sur les contours et les conditions d’application de l’immunité parlementaire, à la lumière d’évènements récentsBehrendt, Christian ; Vrancken, Martin in Revue de la Faculté de Droit de l'Université de Liège (2014), 2014Detailed reference viewed: 241 (41 ULg) Peripheral Synergism Between Tramadol and Ibuprofen in the Formalin TestChavarria Bolanos, Daniel ; Perez-Urizar, Jose; Grandfils, Christian et alin Drug Development Research (2014), 75(4), 224-230Analgesics with different mechanisms of action can be combined in order to obtain Pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical ... [more ▼]Analgesics with different mechanisms of action can be combined in order to obtain Pharmacological synergism, employing lower doses of each agent, thus diminishing side effects. For instance, an atypical dual analgesic such as tramadol (TMD) and a nonsteroidal anti-inflammatory drug such as ibuprofen (IBU) are good candidates to be evaluated when combined and applied peripherally. The present study was conducted to evaluate possible local synergism between TMD and IBU when combined peripherally using the formalin test in rats. The effects of the individual analgesics and their combinations were evaluated simultaneously using a 5% formalin dilution. Dose–effect curves were determined for TMD (50–400 μg/paw) and IBU (1–100 μg/paw). Experimental effective doses were evaluated and isobolographic analyses were constructed to evaluate TMD-IBU combination synergism. Both drugs produced a dose-dependent analgesic effect when applied separately. Isobolographic analysis showed synergism during phase 1 (0–10 min) and phase 2 (15–60 min) when compared with theoretical doses (P < 0.05), with interaction indexes of 0.06 and 0.09, respectively. The present information supports the peripheral analgesic effect of TMD and IBU, especially when combined at appropriate doses. [less ▲]Detailed reference viewed: 6 (0 ULg) From propaganda to commemoration: reworking the national narrative.Hamers, Jérémy ; Van Cauwenberge, Geneviève in Rethinking History (2014), 18(3), 423-437In Belgium, memories of the World War I have contributed to the production and the perpetuation of a fractured national narrative. While the official narration emphasizes the unity of the Belgian state ... [more ▼]In Belgium, memories of the World War I have contributed to the production and the perpetuation of a fractured national narrative. While the official narration emphasizes the unity of the Belgian state and glorifies the heroism of Belgian soldiers acting as a unified force against the German invader, a counter-narrative presents the Flemish soldiers as victims who were used as cannon fodder by the French-speaking commanding elite. In the immediate postwar period, newsreels largely reinforced the image of a national unity during the Great War. Ten years later, however, cinema took an active part in the production of a counter-memory. Met onze jogens aan den IJzer/With Our Troops on the Yser (Clemens De Landtsheer, 1928), a Flemish film, is a key work in this regard. This article first examines the narratives and formal strategies the film resorts to in order to forcefully deconstruct the patriotic narrative and to forge a ‘Flamingant,’ Flemish activist collective memory. It subsequently analyzes more recent Frenchspeaking documentary film projects aiming to commemorate the memory of the Great War. Lacking any overt problematization of their relationship to the Flemish separatist narrative, the documentaries are still shaped by it. Indeed, they either attempt to overcome it by reinforcing Belgium’s sense of national identity or to counterbalance it by putting forward a regional narrative that specifically revives the French-speaking Belgians’ memory of the War. [less ▲]Detailed reference viewed: 8 (0 ULg) Prévention quaternaire : agir est-il toujours justifié en médecine de famille ?Widmer, Daniel; Herzig, Lilly; Jamoulle, Marc in Revue Médicale Suisse (2014), 10(430), 1052-6La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la ... [more ▼]La prévention quaternaire vise à protéger le patient ou la po- pulation de la surmédicalisation. Elle imprègne toute l’activité du médecin de famille par une interrogation tant sur l’utilité de la prévention primaire que du diagnostic précoce, ou sur les risques de la création de nouvelles entités pathologiques et d’une médecine maximaliste. Le médecin de famille favorise la prévention quaternaire en se centrant sur les priorités du patient et sur les ressources locales d’un système de soins efficace. [less ▲]Detailed reference viewed: 11 (1 ULg) Supercritical CO2 and polycarbonate based nanocomposites: A critical issue for foamingMonnereau, Laure; Urbanczyk, Laetitia; Thomassin, Jean-Michel et alin Polymer (2014), 55(10), 2422-2431Supercritical carbon dioxide readily induced foaming of various polymers. In that context, supercritical CO2 was applied to carbon nanotubes based polycarbonate nanocomposites to ensure their foaming ... [more ▼]Supercritical carbon dioxide readily induced foaming of various polymers. In that context, supercritical CO2 was applied to carbon nanotubes based polycarbonate nanocomposites to ensure their foaming. Surprisingly, efficient foaming only occurs when low pressure is applied while at high pressure, no expansion of the samples was observed. This is related to the ability of supercritical carbon dioxide to induce crystallization of amorphous polycarbonate. Moreover, this behaviour is amplified by the presence of carbon nanotubes that act as nucleating agents for crystals birth. The thermal behaviour of the composites was analysed by DSC and DMA and was related to the foaming observations. The uniformity of the cellular structure was analysed by scanning electron microscopy (SEM). By saturating the polycarbonate nanocomposites reinforced with 1 wt% of MWNTs at 100 bar and 100 °C during 16 h, microcellular foams were generated, with a density of 0.62, a cell size ranging from 0.6 to 4 μm, and a cellular density of 4.1 × 1011 cells cm−3. The high ability of these polymeric foams to absorb electromagnetic radiation was demonstrated at low MWNT content as the result of the high affinity of the polycarbonate matrix for MWNTs, and therefore to the good MWNTs dispersion. [less ▲]Detailed reference viewed: 9 (1 ULg) Linear amphiphilic diblock copolymers of lactide and 2-dimethylaminoethyl methacrylate using bifunctional-initiator and one-pot approachesKryuchkov, Maksym A.; Detrembleur, Christophe ; Bazuin, Géraldinein Polymer (2014), 55(10), 2316-2324Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring ... [more ▼]Linear amphiphilic diblock copolymers of polylactide (PLA) and poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) were synthesized by atom transfer radical polymerization (ATRP) of DMAEMA followed by ring-opening polymerization (ROP) of LLA using the bifunctional initiator, 2′-hydroxyethyl 2-bromoisobutyrate. NMR showed that the resulting PLA block was racemic and a quaternization/precipitation technique showed that there were significant amounts of racemic PLA homopolymer. In addition, simultaneous ATRP of DMAEMA and ROP of l-lactide by tin octoate were conducted at varied temperatures, indicating 90 °C as a suitable compromise temperature; this one-pot process also led to racemization and P(L)LA homopolymer. The racemization was attributed to reversible deprotonation of LLA by the N(CH3)2 moiety of (P)DMAEMA and the PLA homopolymer impurity was related to in situ formation of lactoyl lactate (LA–LA) due to nucleophilic ring opening of lactide by the amino moieties of (P)DMAEMA. The methods presented can be useful for the preparation of PDMAEMA–b–PLA/PLA composites in a two-step process or in a single step, one-pot process. [less ▲]Detailed reference viewed: 7 (1 ULg) Long-term evolution and seasonal modulation above Jungfraujoch (46.5°N, 8.0°E): Optimisation of the retrieval strategy, comparison with model and independant observationsBader, Whitney ; Stavrakou, T; Muller, J-F et alin Atmospheric Measurement Techniques. Papers in Open Discussion (2014), 7Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and ... [more ▼]Methanol (CH3OH) is the second most abundant organic compound in the Earth's atmosphere after methane. In this work, we present the first long-term time series of methanol total, lower tropospheric and upper tropospheric-lower stratospheric partial columns derived from the analysis of high resolution Fourier transform infrared solar spectra recorded at the Jungfraujoch station (46.5° N, 3580 m a.s.l.). The retrieval of methanol is very challenging due to strong absorptions of ozone in the region of the selected υ8 band of CH3OH. Two wide spectral intervals have been defined and adjusted in order to maximize the information content. Methanol does not exhibit a significant trend over the 1995–2012 time period, but a strong seasonal modulation characterized by maximum values and variability in June–July, minimum columns in winter and a peak-to-peak amplitude of 130%. In situ measurements performed at the Jungfraujoch and ACE-FTS occultations give similar results for the methanol seasonal variation. The total and lower tropospheric columns are also compared with IMAGESv2 model simulations. There is no systematic bias between the observations and IMAGESv2 but the model underestimates the peak-to-peak amplitude of the seasonal modulations. [less ▲]Detailed reference viewed: 13 (5 ULg) The Role of Anthropic, Ecological, and Social Factors in Sleeping Site Choice by Long‐Tailed Macaques (Macaca fascicularis)Brotcorne, Fany ; Maslarov, Cindy; Wandia, I. Nengah et alin American Journal of Primatology (2014)When choosing their sleeping sites, primates make adaptive trade‐offs between various biotic and abiotic constraints. In human‐modified environments, anthropic factors may play a role. We assessed the ... [more ▼]When choosing their sleeping sites, primates make adaptive trade‐offs between various biotic and abiotic constraints. In human‐modified environments, anthropic factors may play a role. We assessed the influence of ecological (predation), social (intergroup competition), and anthropic (proximity to human settlements) factors in sleeping site choice by long‐tailed macaques (Macaca fascicularis) occupying a habitat at the interface of natural forests and human‐modified zones in Bali Barat National Park, Indonesia. Over the course of 56 nights, we collected data relating to physical features of sleeping trees, patterns of the use of sleeping sites within the home range, pre‐sleep behavior, diurnal ranging patterns and availability of natural and human food. Overall, the macaques used 17 sleeping sites with 37 sleeping trees. When the monkeys slept in forest zones, they selected sleeping trees that had larger trunks but were not significantly taller than surrounding trees. Though the macaques rarely re‐used sleeping sites on consecutive nights, they frequently re‐used four sites over the study period. The group favored sleeping within the core area of its home range, despite the occurrence of frequent agonistic intergroup encounters there. Macaques preferentially selected sleeping trees located within or near human‐modified zones, especially when human food was abundant and natural food was scarce. These results partially support the hypothesis that long‐tailed macaques choose their sleeping sites to avoid predation; proximity to human settlements appears to be the primary factor influencing sleeping site choice in this primate species. Our results reflect the strong influence that anthropic factors have on primates, which subsist in increasingly human‐dominated landscapes. [less ▲]Detailed reference viewed: 10 (4 ULg) Passive temperature tomography experiments to characterize transmissivity and connectivity of preferential flow paths in fractured mediaKlepikova, Maria in Journal of Hydrology (2014)The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive ... [more ▼]The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive tracer to characterize fracture connectivity and hydraulic properties. In particular, we propose a new temperature tomography field method in which borehole temperature profiles are measured under different pumping conditions by changing successively the pumping and observation boreholes. To interpret these temperature-depth profiles, we propose a three step inversion-based framework. We consider first an inverse model that allows for automatic permeable fracture detection from borehole temperature profiles under pumping conditions. Then we apply a borehole-scale flow and temperature model to produce flowmeter profiles by inversion of temperature profiles. This second step uses inversion to characterize the relationship between temperature variations with depth and borehole flow velocities (Klepikova et al., 2011). The third inverse step, which exploits cross-borehole flowmeter tests, is aimed at inferring inter-borehole fracture connectivity and transmissivities. This multi-step inverse framework provides a means of including temperature profiles to image fracture hydraulic properties and connectivity. We test the proposed approach with field data obtained from the Ploemeur (N.W. France) fractured rock aquifer, where the full temperature tomography experiment was carried out between three 100 m depth boreholes 10 m apart. We identified several transmissive fractures and their connectivity which correspond to known fractures and corroborate well with independent information, including available borehole flowmeter tests and geophysical data. Hence, although indirect, temperature tomography appears to be a promising approach for characterizing connectivity patterns and transmissivities of the main flow paths in fractured rock. [less ▲]Detailed reference viewed: 19 (8 ULg) Passive temperature tomography experiments to characterize transmissivity and connectivity of preferential flow paths in fractured mediaKlepikova, Maria in Journal of Hydrology (2014)The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive ... [more ▼]The detection of preferential flow paths and the characterization of their hydraulic properties are major challenges in fractured rock hydrology. In this study, we propose to use temperature as a passive tracer to characterize fracture connectivity and hydraulic properties. In particular, we propose a new temperature tomography field method in which borehole temperature profiles are measured under different pumping conditions by changing successively the pumping and observation boreholes. To interpret these temperature-depth profiles, we propose a three step inversion-based framework. We consider first an inverse model that allows for automatic permeable fracture detection from borehole temperature profiles under pumping conditions. Then we apply a borehole-scale flow and temperature model to produce flowmeter profiles by inversion of temperature profiles. This second step uses inversion to characterize the relationship between temperature variations with depth and borehole flow velocities (Klepikova et al., 2011). The third inverse step, which exploits cross-borehole flowmeter tests, is aimed at inferring inter-borehole fracture connectivity and transmissivities. This multi-step inverse framework provides a means of including temperature profiles to image fracture hydraulic properties and connectivity. We test the proposed approach with field data obtained from the Ploemeur (N.W. France) fractured rock aquifer, where the full temperature tomography experiment was carried out between three 100 m depth boreholes 10 m apart. We identified several transmissive fractures and their connectivity which correspond to known fractures and corroborate well with independent information, including available borehole flowmeter tests and geophysical data. Hence, although indirect, temperature tomography appears to be a promising approach for characterizing connectivity patterns and transmissivities of the main flow paths in fractured rock. [less ▲]Detailed reference viewed: 19 (8 ULg) Enzymatic process for the fractionation of baker’s yeast cell wall (Saccharomyces cerevisiae)Borchani, Chema; Fonteyn, Fabienne; Jamin, Guilhem et alin Food Chemistry (2014), 163Detailed reference viewed: 12 (1 ULg) Using the Multiple SEA Method to Synthesize Pt/Carbon Xerogel Electrocatalysts for PEMFC ApplicationsZubiaur, Anthony ; Chatenet, Marian; Maillard, Frédéric et alin Fuel Cells - From Fundamentals to Systems (2014), 14(3), 343-349Detailed reference viewed: 48 (30 ULg) Effect of the RE (RE = Eu, Er) doping on the structural and textural properties of mesoporous TiO2 thin films obtained by evaporation induced self-assembly methodBorlaf, Mario; Caes, Sébastien ; Dewalque, Jennifer et alin Thin Solid Films (2014), 558Polymeric sol–gel route has been used for the preparation of TiO2 and RE2O3–TiO2 (RE = Eu, Er) mesoporous thin films by evaporation induced self-assembly method using Si (100) as a substrate. The ... [more ▼]Polymeric sol–gel route has been used for the preparation of TiO2 and RE2O3–TiO2 (RE = Eu, Er) mesoporous thin films by evaporation induced self-assembly method using Si (100) as a substrate. The influence of the relative humidity (RH) on the preparation of the film has been studied being necessary to work under 40% RH in order to obtain homogeneous and transparent thin films. The films were annealed at different temperatures until 900 °C/1 h and the anatase crystallization and its crystal size evolution were followed by low angle X-ray diffraction. Neither the anatase–rutile transition nor the formation of other compounds was observed in the studied temperature range. Ellipsoporosimetry studies demonstrated that the thickness of the thin films did not change after calcination at 500 °C, the porosity was constant until 700 °C, the pore size increased and the specific surface area decreased with temperature. Moreover, the effect of the doping with Er3 + and Eu3 + was studied and a clear inhibition of the crystal growth and the sintering process was detected (by transmission electron and atomic force microscopy) when the doped films are compared with the undoped ones. Finally, Eu3 + and Er3 + f–f transitions were detected by PL measurements. [less ▲]Detailed reference viewed: 16 (7 ULg) Dynamic auroral storms on Saturn as observed by the Hubble Space TelescopeNichols, J. D.; Badman, S. V.; Baines, K. H. et alin Geophysical Research Letters (2014), 41We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission ... [more ▼]We present observations of significant dynamics within two UV auroral storms observed on Saturn using the Hubble Space Telescope in April/May 2013. Specifically, we discuss bursts of auroral emission observed at the poleward boundary of a solar wind-induced auroral storm, propagating at ˜330% rigid corotation from near ˜01 h LT toward ˜08 h LT. We suggest that these are indicative of ongoing, bursty reconnection of lobe flux in the magnetotail, providing strong evidence that Saturn's auroral storms are caused by large-scale flux closure. We also discuss the later evolution of a similar storm and show that the emission maps to the trailing region of an energetic neutral atom enhancement. We thus identify the auroral form with the upward field-aligned continuity currents flowing into the associated partial ring current. [less ▲]Detailed reference viewed: 11 (7 ULg) Microlensing of the broad-line region in the quadruply imaged quasar HE0435-1223Braibant, Lorraine ; Hutsemekers, Damien ; Sluse, D. et alin Astronomy and Astrophysics (2014), 565Using infrared spectra of the z = 1.693 quadruply lensed quasar HE0435-1223 acquired in 2009 with the spectrograph SINFONI at the ESO Very Large Telescope, we have detected a clear microlensing effect in ... [more ▼]Using infrared spectra of the z = 1.693 quadruply lensed quasar HE0435-1223 acquired in 2009 with the spectrograph SINFONI at the ESO Very Large Telescope, we have detected a clear microlensing effect in images A and D. While microlensing affects the blue and red wings of the Hα line profile in image D very differently, it de-magnifies the line core in image A. The combination of these different effects sets constraints on the line-emitting region; these constraints suggest that a rotating ring is at the origin of the Hα line. Visible spectra obtained in 2004 and 2012 indicate that the MgII line profile is microlensed in the same way as the Hα line. Our results therefore favour flattened geometries for the low-ionization line-emitting region, for example, a Keplerian disk. Biconical models cannot be ruled out but require more fine-tuning. Flux ratios between the different images are also derived and confirm flux anomalies with respect to estimates from lens models with smooth mass distributions. Based on observations made with the ESO-VLT, Paranal, Chile; Proposal 084.B-0013 (PI: Rix).Tables 2, 3 and Appendix A are available in electronic form at http://www.aanda.org [less ▲]Detailed reference viewed: 11 (6 ULg) Forest radiative transfer models: which approach for which application?Ligot, Gauthier ; Balandier, Philippe; Courbaud, Benoît et alin Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2014), 44(5), 385-397Detailed reference viewed: 40 (16 ULg) The Transcription Factor EGR1 Localizes to the Nucleolus and Is Linked to Suppression of Ribosomal Precursor SynthesisPonti, Donatella; Bellenchi, Gian Carlo; Puca, Rosa et alin PLoS ONE (2014), 9(5), EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the ... [more ▼]EGR1 is an immediate early gene with a wide range of activities as transcription factor, spanning from regulation of cell growth to differentiation. Numerous studies show that EGR1 either promotes the proliferation of stimulated cells or suppresses the tumorigenic growth of transformed cells. Upon interaction with ARF, EGR1 is sumoylated and acquires the ability to bind to specific targets such as PTEN and in turn to regulate cell growth. ARF is mainly localized to the periphery of nucleolus where is able to negatively regulate ribosome biogenesis. Since EGR1 colocalizes with ARF under IGF-1 stimulation we asked the question of whether EGR1 also relocate to the nucleolus to interact with ARF. Here we show that EGR1 colocalizes with nucleolar markers such as fibrillarin and B23 in the presence of ARF. Western analysis of nucleolar extracts from HeLa cells was used to confirm the presence of EGR1 in the nucleolus mainly as the 100 kDa sumoylated form. We also show that the level of the ribosomal RNA precursor 47S is inversely correlated to the level of EGR1 transcripts. The EGR1 iseffective to regulate the synthesis of the 47S rRNA precursor. Then we demonstrated that EGR1 binds to the Upstream Binding Factor (UBF) leading us to hypothesize that the regulating activity of EGR1 is mediated by its interaction within the transcriptional complex of RNA polymerase I. These results confirm the presence of EGR1 in the nucleolus and point to a role for EGR1 in the control of nucleolar metabolism. [less ▲]Detailed reference viewed: 9 (1 ULg) Cassini nightside observations of the oscillatory motion of Saturn's northern auroral ovalBunce, E. J.; Grodent, Denis ; Jinks, S. L. et alin Journal of Geophysical Research. Space Physics (2014), 119recent years we have benefitted greatly from the first in-orbit multi-wavelength images of Saturn's polar atmosphere from the Cassini spacecraft. Specifically, images obtained from the Cassini UltraViolet ... [more ▼]recent years we have benefitted greatly from the first in-orbit multi-wavelength images of Saturn's polar atmosphere from the Cassini spacecraft. Specifically, images obtained from the Cassini UltraViolet Imaging Spectrograph (UVIS) provide an excellent view of the planet's auroral emissions, which in turn give an account of the large-scale magnetosphere-ionosphere coupling and dynamics within the system. However, obtaining near-simultaneous views of the auroral regions with in situ measurements of magnetic field and plasma populations at high latitudes is more difficult to routinely achieve. Here we present an unusual case, during Revolution 99 in January 2009, where UVIS observes the entire northern UV auroral oval during a 2 h interval while Cassini traverses the magnetic flux tubes connecting to the auroral regions near 21 LT, sampling the related magnetic field, particle, and radio and plasma wave signatures. The motion of the auroral oval evident from the UVIS images requires a careful interpretation of the associated latitudinally "oscillating" magnetic field and auroral field-aligned current signatures, whereas previous interpretations have assumed a static current system. Concurrent observations of the auroral hiss (typically generated in regions of downward directed field-aligned current) support this revised interpretation of an oscillating current system. The nature of the motion of the auroral oval evident in the UVIS image sequence, and the simultaneous measured motion of the field-aligned currents (and related plasma boundary) in this interval, is shown to be related to the northern hemisphere magnetosphere oscillation phase. This is in agreement with previous observations of the auroral oval oscillatory motion. [less ▲]Detailed reference viewed: 9 (2 ULg) Et si la promotion de la santé était un art du paradoxe !Vandoorne, Chantal in Education Santé (2014), (300), 6-7Detailed reference viewed: 33 (18 ULg) La spectroscopie proche infrarouge, une technique non destructive dans la lutte contre la contrefaçon des médicamentsMbinze Kindenge, Jérémie ; Kalenda Tshilombo, Nicodème; Chavez, Pierre-François et alin Spectra Analyse (2014), 43Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of ... [more ▼]Near infrared spectroscopy is a very promising and expanding analytical technique. It has to be noted that this technique is becoming more used in the pharmaceutical field for the quality control of products. Indeed near infrared spectroscopy allows to perform fast, non-destructive, versatile analysis of the sample and minimization of the sample preparation. Based on those advantages, this spectroscopic method is one of the first reliable analytical techniques for fighting against counterfeit medicines. [less ▲]Detailed reference viewed: 28 (14 ULg) Vitamin D status of schoolchildren in Northern Algeria, seasonal variations and determinants of vitamin D deficiencyDjennane, M; Lebbah, S; Roux, C et alin Osteoporosis International (2014), 25(5), 1493-502Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25 ... [more ▼]Summary There are no published data on the vitamin D status of children living in North Africa. In 435 healthy Algerian children 5–15 years old, we found that vitamin D insufficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/L) was frequent, especially in winter. Low vitamin D status was associated with increased parathyroid hormone (PTH) and leg deformation Introduction As there are no published data on the vitamin D status of children living in North Africa, we evaluated the 25OHD concentration of healthy Algerian children at the end of summer and at the end of winter. As secondary objectives, we studied the various determinants of vitamin D status and the PTH-25OHD relationship in these subjects. Methods Four hundred thirty-five children 5–15 years old were examined and had a blood sample in September 2010. Of them, 408 were sampled again in March 2011. Results Median 25OHD concentration in the whole group was 71.4 nmol/L in September and 52.9 nmol/L in March. In September, 58.4, 29.9, and 8.1 % had a 25OHD concentration below 75, 50, and 30 nmol/L respectively. In March, these percentages increased to 65.2, 41.4, and 17.4 % for the 75, 50, and 30 nmol/L threshold, respectively. In multivariate analysis, older age, darker skin phototype, low daily vitamin D and calcium intake, poor socioeconomic status, and short daily sun exposure remained significantly associated with a 25OHD <50 nmol/L at both visits. In 72 (16.6 %) children, genu varum/valgum was present. Compared to the 363 children without leg deformation, they presented more frequently with the risk factors of vitamin D insufficiency. They also had lower 25OHD concentrations and higher PTH and tALP. Serum PTH and 25OHD concentrations were negatively and significantly correlated (r=−0.43; p<0.001) without a 25OHD threshold above which PTH does not decrease anymore. Conclusion Despite a sunny environment, vitamin D insufficiency is frequent in healthy Algerian children. [less ▲]Detailed reference viewed: 16 (1 ULg) Stratégies analytiques pour la détection de contrefaçons de médicaments pour la dysfonction érectileSacre, Pierre-Yves ; Deconinck, Eric; Marini Djang'Eing'A, Roland et alin Spectra Analyse (2014), 43Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The ... [more ▼]Erectile dysfunction drugs are among the most counterfeit drug classes in industrialized countries. To fight against this plague, several analytical approaches are available for control laboratories. The present article reviews the main used techniques and concludes presenting a general strategy for the detection and handling of drug counterfeits. [less ▲]Detailed reference viewed: 14 (5 ULg) A new analysis of quasar polarization alignmentsPelgrims, Vincent ; Cudell, Jean-René in Monthly Notices of the Royal Astronomical Society (2014), 442(1), 1239-1248We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that ... [more ▼]We propose a new method to analyse the alignment of optical polarization vectors from quasars. This method leads to a definition of intrinsic preferred axes and to a determination of the probability that the distribution of polarization directions is random. This probability is found to be as low as 0,003 percent for one of the region of redshift. [less ▲]Detailed reference viewed: 8 (1 ULg) Spatiotemporal monitoring of the antibiome secreted by Bacillus biofilms on plant roots using MALDI mass spectrometry imagingDebois, Delphine ; Jourdan, Emmanuel; Smargiasso, Nicolas et alin Analytical Chemistry (2014), 86(9), 4431-4438Some soil Bacilli living in association with plant roots can protect their host from infection by pathogenic microbes and are therefore being developed as biological agents to control plant diseases. The ... [more ▼]Some soil Bacilli living in association with plant roots can protect their host from infection by pathogenic microbes and are therefore being developed as biological agents to control plant diseases. The plant protective activity of these bacteria has been correlated with the potential to secrete a wide array of antibiotic compounds upon growth as planktonic cells in isolated cultures under laboratory conditions. However, in situ expression of these antibiotics in the rhizosphere where bacterial cells naturally colonize root tissues is still poorly understood. In this work, we used Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI MSI) to examine spatio-temporal changes in the secreted antibiome of B. amyloliquefaciens developing as biofilms on roots. Non-ribosomal lipopeptides such as the plant immunity elicitor surfactin or the highly fungitoxic iturins and fengycins were readily produced albeit in different time-frames and quantities in the surrounding medium. Interestingly, MS/MS experiments performed directly from the gelified culture medium, also allowed to identify a new variant of surfactins released at later time points. However, no other bioactive compounds such as polyketides were detected at any time, strongly suggesting that the antibiome expressed in planta by B. amyloliquefaciens does not reflect the vast genetic arsenal devoted to the formation of such compounds. This first dynamic study reveals the power of MALDI MSI as tool to identify and map antibiotics synthesized by root-associated bacteria and more generally, to investigate plant-microbe interactions at the molecular level. [less ▲]Detailed reference viewed: 20 (2 ULg) Angles corniculaires et de demi-cercle chez EuclideBair, Jacques ; Henry, Valérie in Hors Série Tangente (2014), 53Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le ... [more ▼]Les angles datent de l’Antiquité : ils sont présents dans le célèbre ouvrage "Les Éléments" d’Euclide. En partant des "Commentaires" de Proclus, nous présentons la façon dont Euclide introduisait le concept d'angle et sa distinction entre les angles rectilignes et mixtilignes. Les cas des angles corniculaires et de demi-cercle sont spécialement traités. [less ▲]Detailed reference viewed: 10 (0 ULg) Capillary-driven bi-dimensional buoyancy in vertical soap filmsAdami, Nicolas ; Caps, Hervéin Europhysics Letters [=EPL] (2014)Detailed reference viewed: 11 (0 ULg) Des performances de production laitière et de reproduction élevées sont compatibles. Le management en est la clé.Chapaux, Philippe; Glorieux, Géry; Hanzen, Christian in Veterinaria (Bruxelles) : Bulletin d’Information de l’Union Syndicale Vétérinaire Belge (2014)Detailed reference viewed: 122 (6 ULg) A generic approach for solving nonlinear-discrete security-constrained power flow problems in large-scale systemsPlatbrood, Ludovic; Capitanescu, Florin; Crisciu, Horia et alin IEEE Transactions on Power Systems (2014), 29(3), 1194-1203This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to ... [more ▼]This paper proves the practicality of an iterative algorithm for solving realistic large-scale SCOPF problems. This algorithm is based on the combination of a contingency filtering scheme, used to identify the binding contingencies at the optimum, and a network compression method, used to reduce the complexity of the post-contingency models included in the SCOPF formulation. We show that by combining these two complementary ideas, it is possible to solve in a reasonable time SCOPF problems on large power system models with a large number of contingencies. Unlike most results reported for large-scale SCOPF problems, our algorithm uses a non-linear AC network model in both pre-contingency and post-contingency states, optimizes both active/reactive powers flows jointly, and treats the discrete variables. The proposed algorithm is implemented with state-of-the-art solvers and applied to two systems: a national grid with 2563 buses and 1297 contingencies, and a model of the European transmission network with 9241 buses and 12000 contingencies. [less ▲]Detailed reference viewed: 45 (6 ULg) X-ray microtomography: A porosity-based thresholding method to improve soil pore network characterization?Beckers, Eléonore ; Plougonven, Erwan ; Roisin, Christian et alin Geoderma (2014), 219-220X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and ... [more ▼]X-ray microtomography, through quantification of soil structure at the microscale, could greatly facilitate the current understanding of soil hydrodynamic behaviour. However, binarisation method and processing choices are subjective and can have a strong impact on results and conclusions. In this study, we test a new method based on the porosity detectable by X-ray microtomography, while validation is achieved through comparison of soil microtomogram information with soil physical measurements. These measurements consist of water retention and unsaturated hydraulic conductivity using two different soil populations with only structural differences. To assess the porosity-based method performances, we compare it to four other methods, namely the global method of Otsu and three recent soil-dedicated local methods. The robustness of the porosity-based method is also tested in regard to different pre-processing procedures. In this paper we demonstrate that soil segmentation through a porosity-based method is an interesting issue. Indeed, it is less demanding in terms of time and computational requirements than its alternatives, and combines robustness and performances broadly comparable with the recent local methods. [less ▲]Detailed reference viewed: 42 (23 ULg) Is isokinetic eccentric exercise dangerous for the heart?LE GOFF, Caroline ; Kaux, Jean-François ; LAURENT, Terry et alin Isokinetics & Exercise Science (2014), 22(2), 131-136BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order ... [more ▼]BACKGROUND: Very strenuous exercises can be performed on an isokinetic dynamometer in order to evaluate the resistance to fatigue of different muscular groups. Good cardiac function is necessary in order to perform these very intensive exercises; otherwise an acute myocardial dysfunction could theoretically appear in predisposed patients. OBJECTIVE: Our study aimed to observe the cardiovascular impact of a maximal intense isokinetic eccentric exercise performed by a population of sedentary young men. METHODS: Resting and post-exercise (just after, 3 hours and 24 hours after the exercise) blood samples were taken from 12 young male sedentary healthy subjects. These subjects performed an intense maximal eccentric isokinetic exercise of the quadriceps muscle.We evaluated markers of cardiovascular risk (troponin I, highly sensitive troponin T, NT-proBNP,myoglobin), of inflammation (hsCRP) and of oxidative stress (myeloperoxydase, lipidic peroxides, reduced and oxidized glutathione). RESULTS: The following observations were made: no significant increase in cardiac (NT-proBNP, troponins) or inflammation (hsCRP) biomarkers; a significant increase in myoglobin, myeloperoxidase, lipidic peroxides, oxidised glutathione just after the exercise. CONCLUSIONS: No modification in cardiac biomarkers were observed after the maximal eccentric isokinetic exercise. We were thus able to prove that the exercise could be performed without any risk to cardiac function in young sedentary subjects. However, a significant level of oxidative stress was induced by this exercise. [less ▲]Detailed reference viewed: 22 (4 ULg) Lutter contre le fléau des médicaments contrefaitsRudaz, Serge; Hubert, Philippe in Spectra Analyse (2014), 298EditorialDetailed reference viewed: 10 (3 ULg) Compte-rendu de l'ouvrage de Jean-Pierre Meunier : Des images et des mots. Cognition et réflexivité dans la communicationJoachim, Guillaume in Interfaces Numériques (2014), 3(2), 349-352Detailed reference viewed: 5 (0 ULg) Le Musée de la Vie wallonne, indissociablement lié aux dialectologues liégeoisFrankinet, Baptiste in Culture, le Magazine Culturel de l'Université de Liège (2014)Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce ... [more ▼]Au-delà d’un travail pointu de description et d’explication, les dialectologues liégeois ont toujours veillé à préserver les traces d’un patrimoine immatériel menacé de disparition. Selon eux, ce patrimoine dépassait le cadre strictement linguistique ou lexical pour épouser les formes d’un ensemble bien plus vaste : la vie wallonne tout entière. Impossible pour eux d’étudier un dialecte sans veiller à garder les usages ou les objets qu’il nomme, ni le souvenir des gens qui le parlent. Ainsi, en plus d’être des observateurs attentifs à leurs propres parlers, ils devinrent les premiers conservateurs de leur région. [less ▲]Detailed reference viewed: 12 (1 ULg) La réforme de l'Etat et le transfert des compétences: Impact sur la politique du logement en WallonieBourgeois, Marc in Les Echos du logement (2014)Detailed reference viewed: 25 (6 ULg) Implementation of a non-orthogonal constitutive model for the finite element simulation of textile composite drapingPierce, Robert S; Falzon, Brian G; Thompson, Mark C et alin Applied Mechanics and Materials (2014), 553In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This ... [more ▼]In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This paper focuses on the continuum-based, finite element modelling of textile composites as they deform during the draping process. A non-orthogonal constitutive model tracks yarn orientations within a material subroutine developed for Abaqus/Explicit, resulting in the realistic determination of fabric shearing and material draw-in. Supplementary material characterisation was experimentally performed in order to define the tensile and non-linear shear behaviour accurately. The validity of the finite element model has been studied through comparison with similar research in the field and the experimental lay-up of carbon fibre textile reinforcement over a tool with double curvature geometry, showing good agreement. [less ▲]Detailed reference viewed: 82 (8 ULg) The Robust Economic Statistical Design of the Hotelling’s T^2 ChartFaraz, Alireza ; Chalaki, Kamyar; Saniga, Erwin et alin Journal of Statistical Computation & Simulation (2014)Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the ... [more ▼]Economic statistical designs aim at minimizing the cost of process monitoring when a specific scenario or a set of estimated process and cost parameters is given. However, in practical situations the process may be affected by more than one scenario which may lead to severe cost penalties for upsetting the true scenario. This paper presents the robust economic statistical design (RESD) of the T^2 chart to reduce the monetary losses when there are multiple distinct scenarios. The genetic algorithm optimization method is employed here to minimize the total expected monitoring cost across all distinct scenarios. Through two numerical examples the proposed method is illustrated. Simulation studies indicate that the robust economic statistical designs should be encouraged in practice. [less ▲]Detailed reference viewed: 17 (1 ULg) Communiste, social révolutionnaire, antisémite? D'un usage détourné de la radicalité ouvrière par les mouvements terroristes d'extrême gauche allemands.Jander, Martin; Hamers, Jérémy in Quaderni : la Revue de la Communication (2014)Detailed reference viewed: 29 (2 ULg) Dialectique de l'esthétique: Hans-Jürgen Krahl et le "marxisme occidental" entre art et politique.Cavazzini, Andrea ; Hamers, Jérémy in Cahiers du GRM (2014), 5L’article étudie – à partir des fragments de H.-J. Krahl – les débats sur l’esthétique et ses rapports avec la politique et la philosophie de l’histoire depuis la philosophie classique allemande jusqu’aux ... [more ▼]L’article étudie – à partir des fragments de H.-J. Krahl – les débats sur l’esthétique et ses rapports avec la politique et la philosophie de l’histoire depuis la philosophie classique allemande jusqu’aux analyses post-adorniennes de l’industrie culturelle. [less ▲]Detailed reference viewed: 15 (0 ULg) Heterochrony in a complex world: disentangling environmental processes of facultative paedomorphosis in an amphibianDenoël, Mathieu ; Ficetola, Gentile Francescoin Journal of Animal Ecology (2014), 83(3), 606-6151. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the ... [more ▼]1. Heterochrony, the change in the rate or timing of development between ancestors and their descendants, plays a major role in evolution. When heterochrony produces polymorphisms, it offers the possibility to test hypotheses that could explain its success across environments. Amphibians are particularly suitable to exploring these questions because they express complex life cycles (i.e. metamorphosis) that have been disrupted by heterochronic processes (paedomorphosis: retention of larval traits in adults). The large phenotypic variation across populations suggests that more complex processes than expected are operating, but they remain to be investigated through multivariate analyses over a large range of natural populations across time. 2. In this study we compared the likelihood of multiple potential environmental determinants of heterochrony. We gathered data on the proportion of paedomorphic and metamorphic palmate newts (Lissotriton helveticus) across more than 150 populations during 10 years, and used an information-theoretic approach to compare the support of multiple potential processes. 3. Six environmental processes jointly explained the proportion of paedomorphs in populations: predation, water availability, dispersal limitation, aquatic breathing, terrestrial habitat suitability, and anti-predator refuges. Analyses of variation across space and time supported models based on the advantage of paedomorphosis in favourable aquatic habitats. 4. Paedomorphs were favoured in deep ponds, in conditions favourable to aquatic breathing (high oxygen content), with lack of fish, and surrounded by suitable terrestrial habitat. Metamorphs were favoured by banks allowing easy dispersal. 5. These results indicate that heterochrony relies on complex processes involving multiple ecological variables and exemplifies why heterochronic patterns occur in contrasted environments. On the other hand, the fast selection of alternative morphs shows that metamorphosis and paedomorphosis developmental modes could be easily disrupted in natural populations. [less ▲]Detailed reference viewed: 179 (79 ULg) The XMM-Newton view of the yellow hypergiant IRC+10420 and its surroundingsDe Becker, Michaël ; Hutsemekers, Damien ; Gosset, Eric in New Astronomy (2014), 29Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by ... [more ▼]Among evolved massive stars likely in transition to the Wolf-Rayet phase, IRC +10420 is probably one of the most enigmatic. It belongs to the category of yellow hypergiants and it is characterized by quite high mass loss episodes. Even though IRC+10420 benefited of many observations in several wavelength domains, it has never been a target for an X-ray observatory. We report here on the very first dedicated observation of IRC+10420 in X-rays, using the XMM-Newton satellite. Even though the target is not detected, we derive X-ray flux upper limits of the order of 1–3 ×10−14 erg cm−2 s−1 (between 0.3 and 10.0 keV), and we discuss the case of IRC+10420 in the framework of emission models likely to be adequate for such an object. Using the Optical/UV Monitor on board XMM-Newton, we present the very first upper limits of the flux density of IRC +10420 in the UV domain (between 1800 and 2250 Å and between 2050 and 2450 Å). Finally, we also report on the detection in this field of 10 X-ray and 7 UV point sources, and we briefly discuss their properties and potential counterparts at longer wavelengths. [less ▲]Detailed reference viewed: 41 (10 ULg) Shewhart Control Charts for Monitoring Reliability with Weibull LifetimesFaraz, Alireza ; Saniga, Erwin; Heuchenne, Cédric in Quality and Reliability Engineering International (2014)In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method ... [more ▼]In this paper, we present Shewhart type Z ̅ and S2 control charts for monitoring individual or joint shifts in the scale and shape parameters of a Weibull distributed process. The advantage of this method is its ease of use and flexibility for the case where the process distribution is Weibull, although the method can be applied to any distribution. We illustrate the performance of our method through simulation and the application through the use of an actual data set. Our results indicate that Z ̅ and S2 control charts perform well in detecting shifts in the scale and shape parameters. We also provide a guide that would enable a user to interpret out-of-control signals. [less ▲]Detailed reference viewed: 17 (0 ULg) Sur quelques thèmes chez Heiner MullerCavazzini, Andrea in Cahiers du GRM (2014), 5Detailed reference viewed: 5 (0 ULg) EditorialCavazzini, Andrea in Cahiers du GRM (2014), 5Detailed reference viewed: 8 (1 ULg) Coupling X-ray microtomography and macroscopic soil measurements: a method to enhance near saturation functions?Beckers, Eléonore ; Plougonven, Erwan; Gigot, Nicolas et alin Hydrology & Earth System Sciences (2014), 18Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water ... [more ▼]Agricultural management practices influence soil structure, but the characterization of these modifications and consequences are still not completely understood. In this study, we aim at improving water retention and hydraulic conductivity curves using both classical soil techniques and X-ray microtomography in the context of tillage simplification. We show a good match for retention and conductivity functions between macroscopic measurements and microtomographic information. Microtomography highlights the presence of a secondary pore system. Analysis of structural parameters for these pores appears to be significant and offers additional clues for objects differentiation. We show that relatively fast scans supply not only good results, but also enhance near saturation characterization, making microtomography a highly competitive instrument for routine soil characterization. [less ▲]Detailed reference viewed: 57 (29 ULg) Analysis of transient scattering problems using a discontinuous Galerkin method: application to the shielding effectiveness of enclosures with heterogeneous wallsBoubekeur, Mohamed; Kameni, Abelin; Pichon, Lionel et alin International Journal of Numerical Modelling: Electronic Networks, Devices and Fields (2014), 27(3), 626-635In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized ... [more ▼]In this paper, different formulations of Maxwell equations are combined for computing the shielding effectiveness of enclosures made from heterogeneous periodic materials. The validity of the homogenized parameters given by Maxwell-Garnett rules in the frequency domain are tested in the time domain using a nodal discontinuous Galerkin method, which uses an interface condition based on analytical solution in the frequency domain to replace a conductive sheet. This interface condition allows to avoid meshing the thin sheet, thus reducing the computational cost. Results of scattering by composite enclosures are presented in the frequency domain thanks to a Fast Fourier Transform. [less ▲]Detailed reference viewed: 32 (9 ULg) Rénover ou réformer la fiscalité du logement en WallonieXhignesse, Guillaume in Revue Générale de Fiscalité [= RFG] (2014)Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une ... [more ▼]Cette contribution a pour objectif de stimuler la discussion relative à la réforme de la fiscalité du logement en Belgique, et plus particulièrement en Wallonie. Nous y évoquons quelques enjeux d'une telle réforme et nous proposons diverses pistes de réflexions. [less ▲]Detailed reference viewed: 262 (150 ULg) Self-medication in persistent rhinitis: overuse of decongestants in half of the patients.Mehuys, Els; Gevaert, Philippe; Brusselle, Guy et alin Journal of Allergy and Clinical Immunology - In Practice (2014), 2(3), 313-319BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self ... [more ▼]BACKGROUND: Patients with rhinitis often self-medicate with over-the-counter drugs, however this self-treating population has remained largely unstudied. OBJECTIVE: To characterize individuals self-medicating persistent rhinitis and to determine the prevalence of and risk factors for intranasal decongestant overuse within this population. METHODS: A cross-sectional observational study of individuals self-medicating persistent rhinitis (defined according to the Allergic Rhinitis and its Impact on Asthma guidelines). Participants (n = 895) completed a self-administered questionnaire to assess current symptoms, rhinitis medication, and previous physician diagnosis. Intranasal decongestant overuse was defined as daily use for at least 1 year. RESULTS: The vast majority of subjects (95%) had moderate-to-severe rhinitis. Nasal congestion was the predominant symptom (median visual analog scale, 6.6 cm; interquartile range, 3.4 cm). Sixty-five percent had had their current nasal problems for more than 5 years. Approximately 80% had a physician diagnosis (mainly allergic rhinitis or rhinosinusitis). The prevalence of intranasal decongestant overuse was high (49%), despite the fact that most of the patients (80%) were educated about the limit on duration of use. Use of intranasal glucocorticosteroids was inversely related to being an overuser (odds ratio 0.24 [95% CI, 0.17-0.35]). The risk of intranasal decongestant overuse also was reduced by use of other medications (oral H1 antihistamines and decongestants), use of nasal saline solution, and more symptoms of itchy and/or runny eyes or colored mucus. Risk was increased by a more severely blocked nose, longer duration of symptoms, the presence of sleep disturbance, higher body mass index, and previous advice to limit the duration of intranasal decongestant use. CONCLUSION: Half of the individuals self-medicating persistent rhinitis overused intranasal decongestants, despite the fact that they were educated about the limit on duration of use. [less ▲]Detailed reference viewed: 11 (6 ULg) La Fête du 14 juillet à Liège vue par le consul de France Léon Labbé (1919-1930). Une célébration sous surveillanceGenin, Vincent in Bulletin de la Société Royale Le Vieux-Liège (2014), 344Detailed reference viewed: 27 (4 ULg) Projected inhibition of platelet aggregation with ticagrelor twice daily vs. clopidogrel once daily based on patient adherence data (the TWICE project)Vrijens, Bernard ; Claeys, M.J.; LEGRAND, Victor et alin British Journal of Clinical Pharmacology (2014), 77(5), 746-755Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained ... [more ▼]Abstract Aim Twice daily dosing is often perceived as inferior to once daily dosing due to a higher likelihood of missing a dose. However, more important is the extent to which drug action is maintained when doses are delayed or missed. We compared the estimated inhibition of platelet aggregation (eIPA) for ticagrelor twice daily and clopidogrel once daily, based on their pharmacokinetic/ pharmacodynamic relationships and patient dosing history data. Methods Drug dosing histories of 5014 patients prescribed cardiovascular medications (primarily antihypertensive medicines) were extracted from an electronically compiled dosing history database. eIPA levels were simulated for 677 twice daily and 677 once daily dosing histories over a 30 day period, based on published onset/offset models for ticagrelor and clopidogrel IPA characteristics. Results While many patients treated twice daily missed at least one dose in 30 days, only 25.7% missed two consecutive doses. By comparison, 46.8% of patients treated once daily missed at least one dose. Simulations based on patient adherence over time showed that the average mean eIPA for ticagrelor twice daily remained significantly higher than for clopidogrel once daily (81.1% vs. 55.0%, P < 0.001). Ticagrelor twice daily patients had an eIPA below 10% for 0.20% of the 30 day period compared with 2.05% for clopidogrel once daily (P = 0.0001). Conclusions The projected level of platelet inhibition remained higher for ticagrelor twice daily than clopidogrel once daily, mainly due to the higher eIPA level achieved with ticagrelor and the relatively low likelihood of missing two consecutive twice daily doses. This modelling and simulation study suggests a therapeutic benefit of ticagrelor over clopidogrel when taking into account the most common dosing omissions. © 2013 The British Pharmacological Society. [less ▲]Detailed reference viewed: 15 (1 ULg) Resilience to Flooding - Draft Building CodeClarkson, John; Sullican, David; Braun, Kenton et alin PIANC Yearbook 2013 (2014)Detailed reference viewed: 9 (1 ULg) La radicalité ouvrière en Europe. Acteurs, pratiques, discoursGeuens, Geoffrey ; Hamers, Jérémy in Quaderni : la Revue de la Communication (2014), 84(printemps 2014), En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait ... [more ▼]En raison de leur caractère violent et/ou de leur illégalité, certaines luttes ouvrières font l’objet d’un traitement médiatique et politique stéréotypé les maintenant à un niveau que l’on pourrait qualifier d’infrapolitique (« colère », « coup de sang », etc.). Un terme qualifie, très précisément, jusqu'à l'inflation rhétorique ces actions : « radicalité ». Ce dossier analyse les usages de la notion par divers acteurs (journalistes, juristes, politiques…), les liens entre radicalisation des registres d’action et luttes sociales, ainsi que les déterminants politiques, idéologiques et socio-culturels des discours fixant la frontière entre ce qui, dans une société donnée, relève de l'acceptable et de l'inacceptable. Contributeurs au dossier : G. Geuens et J. Hamers (Université de Liège, LEMME), A. Cavazzini (Groupe de Recherches Matérialistes), M. Jander (Freie Universität Berlin, Hamburger Institut für Sozialforschung) B. Carpenter (Duke University) et F.-W. Korsten (Erasmus University, University of Leiden), G. Cormann (Université de Liège), A. Mattoni et M. Vogiatzoglou (European University Institute). [less ▲]Detailed reference viewed: 70 (39 ULg) A Brief Review of Ultraviolet Auroral Emissions on Giant PlanetsGrodent, Denis in Space Science Reviews (2014)The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although ... [more ▼]The morphologies of the ultraviolet auroral emissions on the giant gas planets, Jupiter and Saturn, have conveniently been described with combinations of a restricted number of basic components. Although this simplified view is very handy for a gross depiction of the giant planets’ aurorae, it fails to scrutinize the diversity and the dynamics of the actual features that are regularly observed with the available ultraviolet imagers and spectrographs. In the present review, the typical morphologies of Jupiter and Saturn’s aurorae are represented with an updated and more accurate set of components. The use of sketches, rather than images, makes it possible to compile all these components in a single view and to put aside ultraviolet imaging technical issues that are blurring the emission sources, thus preventing one from disentangling the different auroral signatures. The ionospheric and magnetospheric processes to which these auroral features allude can then be more easily accounted. In addition, the use of components of the same kind for both planets may help to put forward similarities and differences between Jupiter and Saturn. The case of the ice giants Uranus and Neptune is much less compelling since their weak auroral emissions are very poorly documented and one can only speculate about their origin. This review presents a current perspective that will inevitably evolve in the future, especially with upcoming observing campaigns and forthcoming missions like Juno. [less ▲]Detailed reference viewed: 11 (5 ULg) Transiting hot Jupiters from WASP-South, Euler and TRAPPIST: WASP-95b to WASP-101bHellier, Coel; Anderson, D. R.; Collier Cameron, A. et alin Monthly Notices of the Royal Astronomical Society (2014)We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of ... [more ▼]We report the discovery of the transiting exoplanets WASP-95b, WASP-96b, WASP-97b, WASP-98b, WASP-99b, WASP-100b and WASP-101b. All are hot Jupiters with orbital periods in the range 2.1-5.7 d, masses of 0.5-2.8 MJup and radii of 1.1-1.4 RJup. The orbits of all the planets are compatible with zero eccentricity. WASP-99b produces the shallowest transit yet found by WASP-South, at 0.4 per cent. The host stars are of spectral type F2-G8. Five have metallicities of [Fe/H] from -0.03 to +0.23, while WASP-98 has a metallicity of -0.60, exceptionally low for a star with a transiting exoplanet. Five of the host stars are brighter than V = 10.8, which significantly extends the number of bright transiting systems available for follow-up studies. WASP-95 shows a possible rotational modulation at a period of 20.7 d. We discuss the completeness of WASP survey techniques by comparing to the HATnet project. [less ▲]Detailed reference viewed: 8 (0 ULg) Expression of substance P, calcitonin gene-related peptide, β-endorphin and methionine-enkephalin in human dental pulp tissue after orthodontic intrusion: A pilot study.Chavarria Bolanos, Daniel ; Pozos-Guillen, Amaury; Flores-Reyes, Hectorin The angle orthodontist (2014), 84(3), 521-6Detailed reference viewed: 13 (0 ULg) La radicalité ouvrière en mots et en actes. Polysémie des termes et disqualification politiqueGeuens, Geoffrey ; Hamers, Jérémy in Quaderni : la Revue de la Communication (2014), 84 ("La radicalité ouvrière en Europe. Acteurs, pratiques, discours")(printemps 2014), Detailed reference viewed: 52 (24 ULg) Livre et jeu vidéo. IntroductionDozo, Björn-Olav ; Barnabé, Fanny in Mémoires du livre / Studies in Book Culture (2014), 5(2), Introduction au numéro thématique "Livre et jeu vidéo" de la revue Mémoires du livre / Studies in book culture .Detailed reference viewed: 18 (0 ULg) Une histoire de l’hétérogénéité de la classe ouvrière. Refoulement, effets critiques et fragmentation. Présentation de Xavier Vigna, Histoire des ouvriers en France au XXe siècle, Perrin, 2012Mancuso, Eva in Cahiers du GRM (2014), 5Detailed reference viewed: 27 (13 ULg) Méthodes chromatographiques génériques de criblage pour lutter contre les médicaments de qualité inférieureHabyalimana, Védaste; Kalenda Tshilombo, Nicodème; Dispas, Amandine et alin Spectra Analyse (2014), 43Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class ... [more ▼]Poor quality medicines are a danger and a threat to public health. In this context, several generic analytical methods have been developed to screen molecules of interest grouped by pharmacological class using an innovative strategy based on design of experiments followed in some cases by independent component analysis and calculation of design space. Once validated via the classical total error measurement approach, these methods were applied to quantify antimalarial, non-steroidal anti-inflammatory and antibiotic medicines. Alarming results regarding the dosage of these drugs widely used by people confirm the need to fight against this scourge. [less ▲]Detailed reference viewed: 9 (0 ULg) Can we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and factsDELANAYE, Pierre ; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et alin Nephrology Dialysis Transplantation (2014), 29(5), 997-1004Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]Detailed reference viewed: 64 (12 ULg) High resolution saturated hydraulic conductivity logging of friable to poorly indurated borehole cores using air permeability measurementsRogiers, Bart; Winters, P.; Huysmans, Marijke et alin Hydrogeology Journal (2014)Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater ﬂow and contaminant transport in both unsaturated and saturated porous media. This paper investigates ... [more ▼]Saturated hydraulic conductivity (Ks) is one of the most important parameters determining groundwater ﬂow and contaminant transport in both unsaturated and saturated porous media. This paper investigates the hand-held air permeameter technique for high resolution hydraulic conductivity determination on borehole cores using a spatial resolution of ~0.05 m. We test the suitability of such air permeameter measurements on friable to poorly indurated sediments to improve the spatial prediction of classical laboratory based Ks measurements obtained at a much lower spatial resolution (~2 m). About 368 Ks measurements were made on ~350 m of borehole cores originating from the Campine basin, Northern Belgium, while ~5230 air permeability measurements were performed on the same cores. The heterogeneity in sediments, ranging from sand to clayey sand with distinct clay lenses, resulted in a Ks range of seven orders of magnitude. Cross-validation demonstrated that using air permeameter data as secondary variable and laboratory based Ks measurements as primary variable increased performance from R2 = 0.35 for ordinary kriging (laboratory Ks only) to R2 = 0.61 for co-kriging. Due to the large degree of small-scale variability detected by the air permeameter, the spatial granularity in the predicted laboratory Ks also increases drastically. The separate treatment of Kh and Kv revealed considerable anisotropy in certain lithostratigraphical units, while others where clearly isotropic at the sample scale. Air permeameter measurements on borehole cores provide a cost-effective way to improve spatial predictions of traditional laboratory based Ks. [less ▲]Detailed reference viewed: 22 (3 ULg) Towards a real time release approach for manufacturing tablets using NIR spectroscopyPestieau, Aude ; Krier, Fabrice ; Thoorens, Grégory et alin Journal of Pharmaceutical & Biomedical Analysis (2014), 98Detailed reference viewed: 35 (11 ULg) MicroRNA Targeting of CoREST controls polarization of migrating cortical neuronsVolvert; Prévot, Pierre-Paul; Close, Pierre et alin Cell Reports (2014), 7(4), 1168-83Detailed reference viewed: 18 (4 ULg) MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation.Shostak, Kateryna ; Patrascu, F.; Göktuna, Serkan et alin Cell death and differentiation (2014), 5(21), 811-24Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because ... [more ▼]Restoration of p53 tumor suppressor function through inhibition of its interaction and/or enzymatic activity of its E3 ligase, MDM2, is a promising therapeutic approach to treat cancer. However, because the MDM2 targetome extends beyond p53, MDM2 inhibition may also cause unwanted activation of oncogenic pathways. Accordingly, we identified the microtubule-associated HPIP, a positive regulator of oncogenic AKT signaling, as a novel MDM2 substrate. MDM2-dependent HPIP degradation occurs in breast cancer cells on its phosphorylation by the estrogen-activated kinase TBK1. Importantly, decreasing Mdm2 gene dosage in mouse mammary epithelial cells potentiates estrogen-dependent AKT activation owing to HPIP stabilization. In addition, we identified HPIP as a novel p53 transcriptional target, and pharmacological inhibition of MDM2 causes p53-dependent increase in HPIP transcription and also prevents HPIP degradation by turning off TBK1 activity. Our data indicate that p53 reactivation through MDM2 inhibition may result in ectopic AKT oncogenic activity by maintaining HPIP protein levels.Cell Death and Differentiation advance online publication, 31 January 2014; doi:10.1038/cdd.2014.2. [less ▲]Detailed reference viewed: 21 (16 ULg) Determinant of fat mass percentage and absolute fat-free mass in preterm infants at the time of hospital dischargeSimon, Laure; Frondas-Chauty, Anne; SENTERRE, Thibault et alin American Journal of Clinical Nutrition (2014), 100(1), 98-104Detailed reference viewed: 7 (0 ULg) Coupling building energy simulation and computational fluid dynamics: Application to a two-storey house in a temperate climateBarbason, Mathieu ; Reiter, Sigrid in Building & Environment (2014), 75This article reports the coupling of a building energy simulation (BES) made with TRNSYS with a computational fluid dynamics (CFD) simulation made with ANSYS FLUENT and its application to a typical ... [more ▼]This article reports the coupling of a building energy simulation (BES) made with TRNSYS with a computational fluid dynamics (CFD) simulation made with ANSYS FLUENT and its application to a typical Belgian two-storey house. The coupling scheme developed in this study aims to improve the overheating prediction for buildings. This phenomenon is becoming increasingly frequent in Northern Europe due to increased insulation and a lack of sun protection and natural cooling strategies. Complementary contributions of the two numerical approaches are underlined and used to obtain accurate results in an acceptable computing time, even in a thermally stratified room. The space and time coupling is discussed to obtain an optimised tool in which BES is in charge of the primary portion of the effort, while CFD intervenes punctually on one room of interest. The numerical results are compared both qualitatively and quantitatively to the experimental results, and the improved accuracy of the coupled tool compared with a standalone BES is underlined. [less ▲]Detailed reference viewed: 18 (7 ULg) Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human geneticsGusareva, Elena ; Kurey, Irina; Grekov, Igor et alin Biological Reviews of the Cambridge Philosophical Society (2014), 89(2), 375-405Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour ... [more ▼]Immunoglobulin E (IgE) first evolved in mammals. It plays an important role in defence against helminths and parasitic infection and in pathological states including allergic reactions, anti-tumour defence and autoimmune diseases. Elucidation of genetic control of IgE level could help us to understand regulation of the humoral immune response in health and disease, the etiology and pathogenesis of many human diseases, and to facilitate discovery of more effective methods for their prevention and cure. Herein we summarise progress in the genetics of regulation of IgE level in human diseases and show that integration of different approaches and use of animal models have synergistic effects in gaining new knowledge about both protective and pathological roles of this important antibody. [less ▲]Detailed reference viewed: 13 (3 ULg) Hybrid MicroPET Imaging for Dosimetric Applications in Mice: Improvement of Activity Quantification in Dynamic MicroPET Imaging for Accelerated Dosimetry Applied to 6-[ 18 F] Fluoro- L -DOPA and 2-[ 18 F]Fluoro- L -TyrosineBretin, Florian ; Mauxion, T; Warnock, G et alin Molecular Imaging and Biology (2014), 16(3), 383-394Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post ... [more ▼]Purpose: Dynamic microPET imaging has advantages over traditional organ harvesting, but is pronetoquantificationerrorsinsmallvolumes.Hybridimaging,wheremicroPETactivitiesarecross- calibrated using post scan harvested organs, can improve quantification. Organ harvesting, dynamic imaging and hybrid imaging were applied to determine the human and mouse radiation dosimetry of 6-[18 F]fluoro-L-DOPA and 2-[18 F]fluoro-L-tyrosine and compared. Procedures: Two-hour dynamic microPET imaging was performed with both tracers in four separate mice for 18 F-FDOPA and three mice for 18 F-FTYR. Organ harvesting was performed at 2, 5, 10, 30, 60 and 120 min post tracer injection with n=5 at each time point for 18 F-FDOPA and n=3 at each time point for 18 F-FTYR. Human radiation dosimetry projected from animal data was calculated for the three different approaches for each tracer using OLINDA/EXM. S- factors for the MOBY phantom were used to calculate the animal dosimetry. Results: Correlations between dose estimates based on organ harvesting and imaging was improved from r=0.997 to r=0.999 for 18 F-FDOPA and from r=0.985 to r=0.996 (p<0.0001 for all) for 18 F-FTYR by using hybrid imaging. Conclusion: Hybrid imaging yields comparable results to traditional organ harvesting while partially overcoming the limitations of pure imaging. It is an advantageous technique in terms of number of animals needed and labour involved. [less ▲]Detailed reference viewed: 21 (9 ULg) Implementing Human Rights in Benin: The Case of Inheritance DisputesAndreetta, Sophie in Journal of Human Rights Practice (2014)On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to ... [more ▼]On 14 June 2004, Benin ratified a new Code on Persons and Family, adapting its previous dual legal system to the requirements of international human rights law. For the purpose of this article, I chose to focus on inheritance conflicts as a back door to questioning the implementation of a law directly inspired by international human rights standards and principles. When it comes to inheritance disputes, are human rights respected in Benin? What are the discourses of the judges, the lawyers, and the notaries regarding this new Code? How is it implemented and what are the obstacles to it? Combining both qualitative interviews with family members and participant observation in the courtrooms, I compiled a series of case studies, supplemented by interviews with judicial officials. These sets of data allowed me to grasp how laws are enforced and interpreted, and how citizens deal with their families and with the justice system. [less ▲]Detailed reference viewed: 16 (4 ULg) Le Pacifisme d'Auguste Beernaert. De l'homme d'Etat à l'homme des EtatsGenin, Vincent in Espace de Libertés : Magazine du Centre d'Action Laïque (2014), 429Detailed reference viewed: 11 (1 ULg) Transit confirmation and improved stellar and planet parameters for the super-Earth HD 97658 b and its host starVan Grootel, Valérie ; Gillon, Michaël ; Valencia, D. et alin Astrophysical Journal (2014), 786Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition ... [more ▼]Super-Earths transiting nearby bright stars are key objects that simultaneously allow for accurate measurements of both their mass and radius, providing essential constraints on their internal composition. We present here the confirmation, based on Spitzer transit observations, that the super-Earth HD 97658 b transits its host star. HD 97658 is a low-mass ($M_*=0.77\pm0.05\,M_{\odot}$) K1 dwarf, as determined from the Hipparcos parallax and stellar evolution modeling. To constrain the planet parameters, we carry out Bayesian global analyses of Keck-HIRES radial velocities, and MOST and Spitzer photometry. HD 97658 b is a massive ($M_P=7.55^{+0.83}_{-0.79} M_{\oplus}$) and large ($R_{P} = 2.247^{+0.098}_{-0.095} R_{\oplus}$ at 4.5 $\mu$m) super-Earth. We investigate the possible internal compositions for HD 97658 b. Our results indicate a large rocky component, by at least 60% by mass, and very little H-He components, at most 2% by mass. We also discuss how future asteroseismic observations can improve the knowledge of the HD 97658 system, in particular by constraining its age. Orbiting a bright host star, HD 97658 b will be a key target for coming space missions TESS, CHEOPS, PLATO, and also JWST, to characterize thoroughly its structure and atmosphere. [less ▲]Detailed reference viewed: 32 (11 ULg) Factors associated with clinical inertia: an integrative reviewAujoulat, I; Jacquemin, p; Rietzschel, E et alin Advances in Medical Education and Practice (2014), 5Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is ... [more ▼]Failure to initiate or intensify therapy according to evidence-based guidelines is increasingly being acknowledged as a phenomenon that contributes to inadequate management of chronic conditions, and is referred to as clinical inertia. However, the number and complexity of factors associated with the clinical reasoning that underlies the decision-making processes in medicine calls for a critical examination of the consistency of the concept. Indeed, in the absence of information on and justification of treatment decisions that were made, clinical inertia may be only apparent, and actually reflect good clinical practice. This integrative review seeks to address the factors generally associated with clinical inaction, in order to better delineate the concept of true clinical inertia. [less ▲]Detailed reference viewed: 13 (2 ULg) Analyses croisées du monde du travailSmette, Bernard in Cahiers du GRM (2014), 5Detailed reference viewed: 19 (2 ULg) Structured reflection breaks embedded in an online course – Effects on learning experience, time on task and performanceVerpoorten, Dominique ; Westera, Wimin Interactive Learning Environments (2014)The purpose of this paper is to gain insight into the effects of practicing short, frequent and structured reflection breaks interspersed with the learning material in a computer-based course. To that end ... [more ▼]The purpose of this paper is to gain insight into the effects of practicing short, frequent and structured reflection breaks interspersed with the learning material in a computer-based course. To that end, the study sets up a standardised control trial with 2 groups of secondary-school pupils. The study shows that, while performance is not affected by these embedded “reflection rituals”, they significantly impact time on task and perceived learning. The study also suggests that the exposure to such built-in opportunities for reflection modifies the engagement with the content and fosters the claimed readiness for application of a similar reflective approach to learning in other occasions. [less ▲]Detailed reference viewed: 12 (0 ULg) Can we use circulating biomarkers to monitor bone turnover in CKD haemodialysis patients? Hypotheses and factsDELANAYE, Pierre ; Souberbielle, Jean-Claude; Lafage-Proust, Marie-Hélène et alin Nephrology Dialysis Transplantation (2014), 29(5), 997-1004Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical ... [more ▼]Assessing bone turnover is a key diagnostic tool in the global management of chronic kidney disease-mineral and bone disorder (CKD-MBD). Since bone biopsy is invasive and cannot be repeated in clinical practice and because bone histomorphometry is less available due to the lack of specialized laboratories, we will focus on potential biomarkers used to assess and monitor bone turnover. After briefly reviewing the pathophysiology of bone turnover in CKD and haemodialysis patients, we will focus on the strengths and limitations of the now recommended biomarkers, i.e. parathormone and bone-specific alkaline phosphatase. We will consider the clinical and also the biological aspects of the topic and also insist on the use of these biomarkers for the monitoring, and the follow-up of the turnover in haemodialysis subjects. Finally, we will discuss some of the most promising, but still not recommended, emerging biomarkers. [less ▲]Detailed reference viewed: 64 (12 ULg) Influence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituentsVerstringe, Stefanie; Danthine, Sabine ; Blecker, Christophe et alin Food Research International (2014), 62The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]Detailed reference viewed: 21 (2 ULg) Influence of a commercial monoacylglycerol on the crystallization mechanism of palm oil as compared to its pure constituentsVerstringe, Stefanie; Danthine, Sabine ; Blecker, Christophe et alin Food Research International (2014), 62The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main ... [more ▼]The effect of a commercialmonoacylglycerol (MAG),Myverol™18 04-PK(Myverol), on the non-isothermal crystallization mechanismof palm oil (PO) was investigated and compared to the effect of the two main constituents of Myverol, monopalmitin and monostearin. The MAGs were added to PO in concentrations up to 8% and the blends were studied using different techniques (differential scanning calorimetry (DSC), X-ray diffraction (XRD) and polarized light microscopy (PLM)). The DSC crystallization profiles revealed an earlier onset of crystallization along with extra crystallization peaks when MAGs were added to PO. Combined with X-ray results, it could be concluded that the crystallization process of the blends is initiated by the MAGs crystallizing in the α form and then transforming to sub-α. The effect on the non-isothermal crystallization of the PO TAGs is confined to an earlier onset of crystallization, probably through a template effect, and an effect on the crystal structure coarseness. [less ▲]Detailed reference viewed: 21 (2 ULg) Long-wave infrared digital holographic interferometry with diffuser or point source illuminations for measuring deformations of aspheric mirrorsVandenrijt, Jean-François ; Thizy, Cédric ; Queeckers, Patrick et alin Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2014), 53(11), 112309Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a ... [more ▼]Long-wave infrared digital holographic interferometry with CO2 laser and microbolometer arrays has been developed for testing the large deformations of space reflectors. The setup considered is a Mach–Zehnder, associated to the digital holography reconstruction of the wavefront in the inline configuration with phase shifting. Two possibilities exist for illuminating the tested reflector: either with a point source (similarly to classical interferometry) or an extended source (with a diffuser). This paper presents the development of a modular setup which allows comparing both in the case of a parabolic mirror [less ▲]Detailed reference viewed: 20 (2 ULg) Altered Desferrioxamine-mediated Iron Utilization is a Common Trait of bald Mutants of Streptomyces coelicolorLambert, Stéphany ; Traxler, Matthew F; Craig, Matthias et alin Metallomics (2014)Detailed reference viewed: 5 (2 ULg) Poly(methyl methacrylate)/graphene oxide nanocomposites by a precipitation polymerization process and their dielectric and rheological characterizationThomassin, Jean-Michel ; Trifkovic, Milana; Alkarmo, Walid et alin Macromolecules (2014), 47(6), 2149-2155We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a ... [more ▼]We report a method for achieving controlled dispersion of graphene oxide (GO) in poly(methyl methacrylate) (PMMA) via the precipitation polymerization process in a water/ methanol mixture. GO acts as a surfactant and adsorbs on the interface between polymerized PMMA particles and solvent mixture. Scanning electron and transmission electron microscopy confirmed that the precipitate consists of polymer particles (<1 μm) surrounded by the GO sheets. Compression molding of the precipitate yields a polymer nanocomposite with the GO organized into a regularly spaced 3D network which percolates at 0.2 wt % GO. Simple thermal reduction of the GO sheets dispersed in PMMA at relatively low temperature (210 °C) achieved electrical conductivity higher than 10−2 S/m at 0.4 wt % of GO. Parallel dielectric and rheological characterization demonstrated that the thermal reduction is a quite fast process without significant degradation of the polymer. The study should open up new opportunities in the design of GO-based polymer nanocomposites. [less ▲]Detailed reference viewed: 53 (11 ULg) Brown rust disease control in winter wheat: II. Exploring the optimization of fungicide sprays through a decision support systemEl Jarroudi, Moussa ; kOUADIO, Louis; Giraud, Frédéric et alin Environmental Science & Pollution Research (2014), 21(4), 4809-4818A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall ... [more ▼]A decision support system (DSS) involving an approach for predicting wheat leaf rust (WLR) infection and progress based on night weather variables (i.e., air temperature, relative humidity, and rainfall) and a mechanistic model for leaf emergence and development simulation (i.e., PROCULTURE) was tested in order to schedule fungicide time spray for controlling leaf rust progress in wheat fields. Experiments including a single fungicide treatment based upon the DSS along with double and triple treatment were carried out over the 2007–2009 cropping seasons in four representative Luxembourgish wheat field locations. The study showed that the WLR occurrences and severities differed according to the site, cultivar, and year. We also found out that the single fungicide treatment based on the DSS allowed a good protection of the three upper leaves of susceptible cultivars in fields with predominant WLR occurrences. The harvested grain yield was not significantly different from that of the double and triple fungicide-treated plots (P < 0.05). Such results could serve as basis or be coupled to cost-effective and environmentally friendly crop management systems in operational context. [less ▲]Detailed reference viewed: 22 (3 ULg) Stochastic exposure to sub-lethal high temperature enhances exopolysaccharides (EPS) excretion and improves Bifidobacterium bifidum cell survival to freeze-dryingNguyen, Huu Thanh ; Razafindralambo, Hary; Blecker, Christophe et alin Biochemical Engineering Journal (2014), 88Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal ... [more ▼]Exposure of microbial cells to sub-lethal stresses is known to increase cell robustness. In this work, a two-compartment bioreactor in which microbial cells are stochastically exposed to sub-lethal temperature stresses has been used in order to investigate the response of the stress sensitive Bifidobacterium bifidum THT 0101 to downstream processing operations. A stochastic model validated by residence time distribution experiments has shown that in the heat-shock configuration, a two-compartment bioreactor (TCB) allows the exposure of microbial cells to sub-lethal temperature of 42°C for a duration comprised between 100 and 300 seconds. This exposure resulted in a significant increase of cell resistance to freeze-drying by comparison with cells cultivated in conventional bioreactors or in the TCB in the cold shock mode (CS-TCB). The mechanism behind this robustness seems to be related with the coating of microbial cells with exopolysaccharide (EPS), as assessed by the change of the zeta potential and the presence of higher EPS concentration after heat shock. Conditioning of Bifidobacteria on the basis of the heat shock technique is interesting from the practical and economical point of view since this strategy can be directly implemented in the bioreactor during stationary phase preceding cell recovery and freeze-drying [less ▲]Detailed reference viewed: 38 (13 ULg) David Knoke, Economic networksDufays, Frédéric in Lectures (2014)Detailed reference viewed: 15 (1 ULg) Elaboration of drug nanocarriers based on a glucosamine labeled amphiphilic polymerBoyère, Cédric; Duhem, N; Debuigne, Antoine et alin Polymer Chemistry (2014), 5(8), 3030-3037A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG ... [more ▼]A new functional polymer micelle with high loading efficiency of a poorly soluble drug was made of biocompatible and/or biosourced compounds, i.e. cholesterol-poly(ethylene glycol)-glucosamine (Chol-PEG-GlcNH2). A synthesis strategy combining enzymatic and metal-free click chemistry was developed in order to meet the increasingly stringent requirements of biomedical applications. After the self-assembly of the Chol-PEG-GlcNH2 amphiphilic polymer in water, the presence of glucosamine at the micelle surface confers an active targeting moiety to the nanocarriers whereas protonation of the peripheral primary amine delay their aggregation. The complete characterization of this novel functional amphiphilic bioconjugate is presented as well as its aqueous solution behaviour and encapsulation efficiency using ketoconazole as a model hydrophobic drug. [less ▲]Detailed reference viewed: 46 (9 ULg) Dual Mode of Action of Amylolysin, a Type-B Lantibiotic Produced by Bacillus amyloliquefaciens GA1Arguelles Arias, Anthony ; Joris, Bernard ; Fickers, Patrickin Protein & Peptide Letters (2014), 4Detailed reference viewed: 5 (1 ULg) (Co)Polymerization of vinyl levulinate by cobalt-mediated radical polymerization and functionalization by ketoxime click chemistryAllaoua, Imène; Eleuterio, Beatriz; Obadia, Mona M. et alin Polymer Chemistry (2014), 5(8), 2973-2979Vinyl levulinate is synthesized from levulinic acid by palladium-catalyzed vinyl exchange and is characterized by NMR and ESI-HRMS techniques. Homopolymerization of vinyl levulinate and random ... [more ▼]Vinyl levulinate is synthesized from levulinic acid by palladium-catalyzed vinyl exchange and is characterized by NMR and ESI-HRMS techniques. Homopolymerization of vinyl levulinate and random copolymerization with vinyl acetate by cobalt-mediated radical polymerization affords well-defined ketone functionalized poly(vinyl ester)s. The impact of temperature, solvent and theoretical degree of polymerization on monomer conversion and control of the polymerization is studied by 1H NMR and size exclusion chromatography techniques. The ketoxime conjugation of O-benzylhydroxylamine with the pendant ketone functionality of poly(vinyl levulinate-co-vinyl acetate) is demonstrated. [less ▲]Detailed reference viewed: 10 (1 ULg) Evaluation of automated immunoassays for 25 (OH)-vitamin D determination in different critical populations before and after standardization of the assaysCAVALIER, Etienne ; LUKAS, Pierre ; CRINE, Yannick et alin Clinica Chimica Acta (2014), 431Detailed reference viewed: 71 (22 ULg) Preparation of polyaniline-modified local clay and study of its sorption capacityBenhebal, Hadj; Chaid, Messaoud; Léonard, Angélique et alin Journal of Nanostructure in Chemistry (2014), 4(98), 6Clay minerals are frequently used in adsorption processes with aqueous solution; it was found that the adsorption properties of clays change when the samples are modified. In this context, polyaniline ... [more ▼]Clay minerals are frequently used in adsorption processes with aqueous solution; it was found that the adsorption properties of clays change when the samples are modified. In this context, polyaniline-modified clay nanocomposite (at 10 %) was prepared by in situ polymerization processes. The structural and morphological characteristics of the synthesized material are systematically examined by X-ray diffraction, scanning electron microscopy, thermo-gravimetry, differential scanning calorimetry and infrared spectroscopy techniques. The adsorption property of the modified clay was evaluated for the removal of a reactive dye (methylene blue) from aqueous solution at room temperature (25 C) via batch adsorption. [less ▲]Detailed reference viewed: 20 (3 ULg) Après le CommunismeFlorence, Eric in Vie des Idées (La) (2014)Souvent traités séparément, les cas chinois et européens de l’Est sont abordés conjointement dans un ouvrage interdisciplinaire consacré aux institutions politiques et sociales, aux transformations socio ... [more ▼]Souvent traités séparément, les cas chinois et européens de l’Est sont abordés conjointement dans un ouvrage interdisciplinaire consacré aux institutions politiques et sociales, aux transformations socio-économiques et aux relations entre État et société. L’angle d’approche tend à présenter l’action de l’État-Parti en Chine sous un jour favorable. [less ▲]Detailed reference viewed: 10 (0 ULg) Application of isotopic tracers as a tool for understanding hydrodynamic behavior of the highly exploited Diass aquifer system (Senegal)Madioune, Diakher Hélène; Faye, Serigne; Orban, Philippe et alin Journal of Hydrology (2014), 511The Diass horst aquifer system located 50 km east of Dakar (Senegal) is exploited in two main aquifers covered by a sandy superficial aquifer: the confined/unconfined Palaeocene karstic limestone and the ... [more ▼]The Diass horst aquifer system located 50 km east of Dakar (Senegal) is exploited in two main aquifers covered by a sandy superficial aquifer: the confined/unconfined Palaeocene karstic limestone and the confined Maastrichtian sandstone aquifer underneath. This system has experienced intensive groundwater abstraction during the last 50 years to supply increasing water demand, agricultural and industrial needs. The high abstraction rate from 1989 to 2009 (about 109,000 m3/d) has caused a continuous groundwater level decline (up to 30 m), a modification of the groundwater flow and salinization in parts of the aquifers. The objective of the study is to improve our understanding of the system functioning with regards to high pumping, identify the geochemical reactions that take place in the system, infer origin and timing of recharge by using mainly stable (δ18O, δ2H, 13C) and radioactive (3H and 14C) isotopes. Water types defined in the Piper diagram vary in order of abundance from Ca–HCO3 (65%), Ca/Na–Cl (20%), Na–HCO3 (3%) and Na–Cl (12%). Values of δ18O and δ2H for the superficial aquifer range between −5.8 and −4.2‰ and between −42 and −31‰, respectively. For the Palaeocene aquifer they range from −5.8 to −5.0‰ and from −38 to −31‰, respectively; values in the Maastrichtian aquifer are between −5.9 and −4.3‰ for δ18O and −38 to −26‰ for δ2H. Plotted against the conventional δ18O vs δ2H diagram, data from the upper aquifer exhibit a dispersed distribution with respect to isotopic fractionation while those of the Palaeocene and Maastrichtian aquifers are aligned parallel and slightly below/or on the Global Meteoric Water Line (GMWL) evidencing ancient waters which had evaporated during infiltration. The low tritium (generally <0.7 TU) and 14C (0.7–57.2 pmc) contents indicate predominance of older water being recharged during the Pleistocene and Holocene periods. However, few boreholes which exhibit high tritium (1.2–4.3 TU) and 14C (65.7–70.8 pmc) values indicate some mixture with recent water likely through faulting and vertical drainage from the upper to deeper aquifers as well as lateral flow along flow paths to the piezometric depressions created by pumping. [less ▲]Detailed reference viewed: 34 (4 ULg) Le TAT de Adolf EichmannPeralta, Alberto; Kramer, Richard; Stassart, Martine in Szondiana (2014), 33(Décembre 2013), 8-45Under consideration of three major personality tests (TAT, Rorschach, Szondi), it appears that Adolf Eichmann chiefdirector for the deportation of jewish people from 1942 to 1945 was no common individual ... [more ▼]Under consideration of three major personality tests (TAT, Rorschach, Szondi), it appears that Adolf Eichmann chiefdirector for the deportation of jewish people from 1942 to 1945 was no common individual but a perverse sadomasochistic one with schizoparanoïd features under an osessionnal mask. These data contradict the famous opinion of Hannah Arendt about the "banality of evil". [less ▲]Detailed reference viewed: 43 (3 ULg) A multiple-level study of metal tolerance in Salix fragilis and Salix aurita clonesEvlard, Aricia ; Sergeant, Kjell; Printz, Bruno et alin Journal of Proteomics (2014), 101CThe response of two willow clones (Salix fragilis (Sf) and S. aurita (Sa)) to the presence of metals (Zn, Cu, Cd, Ni) was studied. Rooted cuttings were planted in control and contaminated soil. After 100 ... [more ▼]The response of two willow clones (Salix fragilis (Sf) and S. aurita (Sa)) to the presence of metals (Zn, Cu, Cd, Ni) was studied. Rooted cuttings were planted in control and contaminated soil. After 100 days, different parameters (biomass, chlorophyll fluorescence (Fv/Fm), pigment and sugar concentrations, electrolyte leakage and proteome-level changes) were analyzed. The growth of Sa was not influenced by metals whereas Sf produced significantly less biomass when exposed to the pollutants. Furthermore, although Sa did not show a growth reduction in the presence of metals, the overall view of the physiological results among others the changes in the accumulation of sugars and pigments indicated that metals had a more severe impact on this clone. The response at the proteome level confirmed these observations. The growth reduction and the proteomic changes in Sf indicate that this clone adjusts its metabolism to maintain cellular homeostasis. Sa on the contrary maintains growth but the physiological and proteomics data suggests that this can only be done at the cost of cellular deregulation. Therefore high biomass is not linked with a good tolerance strategy. In a long-term study the survival of Sa might be compromised making it a poorer candidate for phytoremediation efforts. [less ▲]Detailed reference viewed: 21 (2 ULg) The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits.Parameswaran, Nevi; Dewals, Benjamin G ; Giles, Tom C. et alin Virus research (2014)Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene ... [more ▼]Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene or not and whether it is involved in pathogenesis by interference with host transcription pathways. An A2 gene knockout (A2DeltaAlHV-1) virus, revertant (A2revAlHV-1) virus, and wild-type virus (wtAlHV-1) were used to infect three groups of rabbits. A2DeltaAlHV-1-infected rabbits succumbed to MCF, albeit with a delayed onset compared to the control groups, so A2 is not a critical virulence factor. Differential gene transcription analysis by RNAseq and qRT-PCR validation of a selection of these was performed in infected large granular lymphocyte (LGL) T cells obtained in culture from the MCF-affected animals. A2 was involved in the transcriptional regulation of immunological, cell cycle and apoptosis pathways. In particular, there was a bias towards gammadelta T cell receptor (TCR) expression and downregulation of alphabeta TCR. TCR signalling, apoptosis, cell cycle, IFN-gamma and NFAT pathways were affected. Of particular interest was partial inhibition of the cytotoxicity-associated pathways involving perforin and the granzymes A and B in the A2DeltaAlHV-1-infected LGLs compared to controls. In functional assays, A2DeltaAlHV-1-infected LGLs were significantly less cytotoxic than wtAlHV-1- and A2revAlHV-1-infected LGLs using rabbit corneal epithelial cells (SIRC) as targets. This implies that A2 is involved in a pathway enhancing the expression of LGL cytotoxicity. This is important as virus-infected T cell cytotoxicity in vivo has been suggested as a potential mechanism of disease induction in MCF. [less ▲]Detailed reference viewed: 11 (4 ULg) Ultrasonographic Percutaneous Anatomy of the Atlanto-Occipital Region and Indirect Ultrasound-Guided Cisternal Puncture in the Dog and the CatEtienne, Anne-Laure ; Audigié, F.; Peeters, Dominique et alin Anatomia, Histologia, Embryologia (2014)Detailed reference viewed: 25 (1 ULg) The PLATO Simulator: modelling of high-precision high-cadence space-based imagingMarcos-Arenal, P.; Zima, W.; De Ridder, J. et alin Astronomy and Astrophysics (2014)Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in ... [more ▼]Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in the course of the observations make such simulations an indispensable part of the assessment and design study of any space-based mission. We present a formalism to model and simulate photometric time series of CCD images by including models of the CCD and its electronics, the telescope optics, the stellar field, the jitter movements of the spacecraft, and all important natural noise sources. This formalism has been implemented in a versatile end-to-end simulation software tool, called PLATO Simulator, specifically designed for the PLATO space mission to be operated from L2, but easily adaptable to similar types of missions. We provide a detailed description of several noise sources and discuss their properties, in connection with the optical design, the allowable level of jitter, the quantum efficiency of the detectors, etc. The expected overall noise budget of generated light curves is computed as a function of the stellar magnitude, for different sets of input parameters describing the instrument properties. The simulator is offered to the scientific community for future use. [less ▲]Detailed reference viewed: 16 (7 ULg) Rates of CTL Killing in Persistent Viral Infection In VivoElemans, Marjet; Florins, Arnaud; Willems, Luc et alin PLoS Computational Biology (2014), 4The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected ... [more ▼]The CD8+ cytotoxic T lymphocyte (CTL) response is an important defence against viral invasion. Although CTL-mediated cytotoxicity has been widely studied for many years, the rate at which virus-infected cells are killed in vivo by the CTL response is poorly understood. To date the rate of CTL killing in vivo has been estimated for three virus infections but the estimates differ considerably, and killing of HIV-1-infected cells was unexpectedly low. This raises questions about the typical anti-viral capability of CTL and whether CTL killing is abnormally low in HIV-1. We estimated the rate of killing of infected cells by CD8+ T cells in two distinct persistent virus infections: sheep infected with Bovine Leukemia Virus (BLV) and humans infected with Human T Lymphotropic Virus type 1 (HTLV-1) which together with existing data allows us to study a total of five viruses in parallel. Although both BLV and HTLV-1 infection are characterised by large expansions of chronically activated CTL with immediate effector function ex vivo and no evidence of overt immune suppression, our estimates are at the lower end of the reported range. This enables us to put current estimates into perspective and shows that CTL killing of HIV-infected cells may not be atypically low. The estimates at the higher end of the range are obtained in more manipulated systems and may thus represent the potential rather than the realised CTL efficiency. [less ▲]Detailed reference viewed: 4 (0 ULg) Exploiting SNP Correlations within Random Forest for Genome-Wide Association StudiesBotta, Vincent ; Louppe, Gilles ; Geurts, Pierre et alin PLoS ONE (2014)The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however ... [more ▼]The primary goal of genome-wide association studies (GWAS) is to discover variants that could lead, in isolation or in combination, to a particular trait or disease. Standard approaches to GWAS, however, are usually based on univariate hypothesis tests and therefore can account neither for correlations due to linkage disequilibrium nor for combinations of several markers. To discover and leverage such potential multivariate interactions, we propose in this work an extension of the Random Forest algorithm tailored for structured GWAS data. In terms of risk prediction, we show empirically on several GWAS datasets that the proposed T-Trees method significantly outperforms both the original Random Forest algorithm and standard linear models, thereby suggesting the actual existence of multivariate non-linear effects due to the combinations of several SNPs. We also demonstrate that variable importances as derived from our method can help identify relevant loci. Finally, we highlight the strong impact that quality control procedures may have, both in terms of predictive power and loci identification. [less ▲]Detailed reference viewed: 40 (8 ULg) Nest grouping patterns of bonobos (Pan paniscus) in relation to fruit availability in a forest-savannah mosaicSerckx, Adeline ; Huynen, Marie-Claude ; Bastin, Jean-François et alin PLoS ONE (2014)A topic of major interest in socio-ecology is the comparison of chimpanzees and bonobos’ grouping patterns. Numerous studies have highlighted the impact of social and environmental factors on the ... [more ▼]A topic of major interest in socio-ecology is the comparison of chimpanzees and bonobos’ grouping patterns. Numerous studies have highlighted the impact of social and environmental factors on the different evolution in group cohesion seen in these sister species. We are still lacking, however, key information about bonobo social traits across their habitat range, in order to make accurate inter-species comparisons. In this study we investigated bonobo social cohesiveness at nesting sites depending on fruit availability in the forest-savannah mosaic of western Democratic Republic of Congo (DRC), a bonobo habitat which has received little attention from researchers and is characterized by high food resource variation within years. We collected data on two bonobo communities. Nest counts at nesting sites were used as a proxy for night grouping patterns and were analysed with regard to fruit availability. We also modelled bonobo population density at the site in order to investigate yearly variation. We found that one community density varied across the three years of surveys, suggesting that this bonobo community has significant variability in use of its home range. This finding highlights the importance of forest connectivity, a likely prerequisite for the ability of bonobos to adapt their ranging patterns to fruit availability changes. We found no influence of overall fruit availability on bonobo cohesiveness. Only fruit availability at the nesting sites showed a positive influence, indicating that bonobos favour food ‘hot spots’ as sleeping sites. Our findings have confirmed the results obtained from previous studies carried out in the dense tropical forests of DRC. Nevertheless, in order to clarify the impact of environmental variability on bonobo social cohesiveness, we will need to make direct observations of the apes in the forest-savannah mosaic as well as make comparisons across the entirety of the bonobos’ range using systematic methodology. [less ▲]Detailed reference viewed: 38 (8 ULg) Conceptual metaphors as a tool for the efficient teaching of Dutch and German posture verbsDe Knop, Sabine; Perrez, Julien in Review of Cognitive Linguistics (2014), 12(1), 1-29The article deals with the typological differences between the Romance lan- guage French and the Germanic languages German and Dutch for the linguistic expressions of posture and location. It describes ... [more ▼]The article deals with the typological differences between the Romance lan- guage French and the Germanic languages German and Dutch for the linguistic expressions of posture and location. It describes how these typological differ- ences can be problematic for French-speaking learners of German and Dutch. The main difference between both types of languages is that posture and loca- tion tend to be encoded by posture verbs in Germanic languages and by very general verbs in Romance languages (Talmy 2000). After a detailed description of the semantic networks of the German and Dutch posture verbs, the paper takes a critical look at how these expressions are dealt with in teaching manuals. It further presents strategies for the efficient teaching of posture verbs to foreign language learners. These strategies are among others awareness-raising exercis- es about the compulsory use of posture verbs in Germanic languages and the description of conceptual metaphors in different languages. These pedagogical avenues for the efficient teaching of the Dutch and German posture verbs con- stitute a first step towards the elaboration of an experimental set-up aiming at verifying them. [less ▲]Detailed reference viewed: 21 (8 ULg)