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See detailROLE OF IMAGING IN LEFT ATRIAL APPENDAGE OCCLUSION
LEMPEREUR, Mathieu ULg; AMINIAN, Adel; DULGHERU, Raluca Elena ULg et al

in international journal of cardiovascular practice (2017), 2(2), 33-43

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See detailUsefulness of multi-breed models in genetic evaluation of direct and maternal calving ease in Holstein and Belgian Blue Walloon purebreds and crossbreds
Vanderick, Sylvie ULg; Gillon, Alain; Glorieux, Géry et al

in Livestock Science (2017), 198

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and ... [more ▼]

The objective of this study was to verify the feasibility of a joint genetic evaluation system for calving ease trait of Belgian Blue (BBB) and Holstein (HOL) Walloon cattle based on data of purebred and crossbred animals. Variance components and derived genetic parameters for purebred BBB and HOL animals were estimated by using single-breed linear animal models. This analysis showed clear genetic differences between breeds. Estimates of direct and maternal heritabilities (± standard error) were 0.34 (±0.02) and 0.09 (±0.01) for BBB, respectively, but only 0.09 (±0.01) and 0.04 (±0.01) for HOL, respectively. Moreover, a significant negative genetic correlation between direct and maternal effects was obtained in both breeds: −0.46 (±0.04) for BBB and −0.29 (±0.11) for HOL. Variance components and derived genetic parameters for purebred BBB and HOL and crossbred BBB ×× HOL cattle were then estimated by using two multi-breed linear animal models: a multi-breed model based on a random regression test-day model (Model MBV), and a multi-breed model based on the random regression multi-breed model (Model MBSM). Both multi-breed models use different functions of breed proportions as random regressions, thereby enabling modelling different additive effects according to animal's breed composition. The main difference between these models is the way in which relationships between breeds are accounted for in the genetic (co)variance structure. Genetic parameters differed between single-breed and multi-breed analysis, but are similar to the literature. For BBB, estimates of direct and maternal heritabilities (±SE) were 0.45 (±0.07) and 0.08 (±0.01) by using Model MBV, and 0.45 (±0.08) and 0.09 (±0.02) for Model MBSM, respectively. For HOL, these estimates were 0.18 (±0.04) and 0.05 (±0.01) using Model MBV, and 0.16 (±0.04) and 0.05 (±0.01) for Model MBSM, respectively. Reliability gains (up to 25%) indicated that the use of crossbred data in the multi-breed models had a positive influence on the estimation of genetic merit of purebred animals. A slight re-ranking of purebred sires and maternal grandsires was observed between single-breed and multi-breed models. Moreover, both multi-breed models can be considered as quasi-equivalent models because they performed almost equally well with respect to MSE and correlations, for purebred and crossbred animals. [less ▲]

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See detailOvertopping induced failure of non-cohesive, homogenous fluvial dikes
Rifai, Ismail ULg; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Water Resources Research (2017), 53(4), 33733386

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of ... [more ▼]

Accurate predictions of breach characteristics are necessary to reliably estimate the outflow hydrograph and the resulting inundation close to fluvial dikes. Laboratory experiments on the breaching of sand-filled fluvial dikes were performed, considering a flow parallel to the dike axis. The breach was triggered by overtopping of the dike crest. A detailed monitoring of the transient evolution of the breach geometry was conducted, providing key insights into the gradual and complex processes involved in fluvial dike failure. The breach develops in two phases: (1) the breach becomes gradually wider and deeper eroding on the downstream side along the main channel, and (2) breach widening controlled by side slope failures, continuing in the downstream direction only. Increasing the inflow discharge in the main channel, the breach formation time decreases significantly and the erosion occurs preferentially on the downstream side. The downstream boundary condition has a strong influence on the breach geometry and the resulting outflow hydrograph. [less ▲]

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See detailPlantations et bornage : prérogatives d'un emphytéote
Popa, Ruxandra ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederecters (2017), 3-4(2017),

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See detailAn investigation into the fraction of particle accelerators among colliding-wind binaries. Towards an extension of the catalogue
De Becker, Michaël ULg; Benaglia, Paula; Romero, Gustavo E. et al

in Astronomy and Astrophysics (2017), 600

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact ... [more ▼]

Particle-accelerating colliding-wind binaries (PACWBs) are multiple systems made of early-type stars able to accelerate particles up to relativistic velocities. The relativistic particles can interact with different fields (magnetic or radiation) in the colliding-wind region and produce non-thermal emission. In many cases, non-thermal synchrotron radiation might be observable and thus constitute an indicator of the existence of a relativistic particle population in these multiple systems. To date, the catalogue of PACWBs includes about 40 objects spread over many stellar types and evolutionary stages, with no clear trend pointing to privileged subclasses of objects likely to accelerate particles. This paper aims at discussing critically some criteria for selecting new candidates among massive binaries. The subsequent search for non-thermal radiation in these objects is expected to lead to new detections of particle accelerators. On the basis of this discussion, some broad ideas for observation strategies are formulated. At this stage of the investigation of PACWBs, there is no clear reason to consider particle acceleration in massive binaries as an anomaly or even as a rare phenomenon. We therefore consider that several PACWBs will be detected in the forthcoming years, essentially using sensitive radio interferometers which are capable of measuring synchrotron emission from colliding-wind binaries. Prospects for high-energy detections are also briefly addressed. [less ▲]

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See detail18-Fluoro-deoxyglucose uptake in inflammatory hepatic adenoma: A case report.
Liu, Willy; Delwaide, Jean ULg; BLETARD, Noëlla ULg et al

in World Journal of Hepatology (2017), 9(11), 562-566

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and ... [more ▼]

Positron emission tomography computed tomography (PET-CT) using 18-Fluoro-deoxyglucose (18FDG) is an imaging modality that reflects cellular glucose metabolism. Most cancers show an uptake of 18FDG and benign tumors do not usually behave in such a way. The authors report herein the case of a 38-year-old female patient with a past medical history of cervical intraepithelial neoplasia and pheochromocytoma, in whom a liver lesion had been detected with PET-CT. The tumor was laparoscopically resected and the diagnosis of inflammatory hepatic adenoma was confirmed. This is the first description of an inflammatory hepatic adenoma with an 18FDG up-take. [less ▲]

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See detailPerspective and priorities for improvement of parathyroid hormone (PTH) measurement - A view from the IFCC Working Group for PTH.
Sturgeon, Catharine M.; Sprague, Stuart; Almond, Alison et al

in Clinica Chimica Acta (2017), 467

Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral ... [more ▼]

Parathyroid hormone (PTH) measurement in serum or plasma is a necessary tool for the exploration of calcium/phosphate disorders, and is widely used as a surrogate marker to assess skeletal and mineral disorders associated with chronic kidney disease (CKD), referred to as CKD-bone mineral disorders (CKD-MBD). CKD currently affects >10% of the adult population in the United States and represents a major health issue worldwide. Disturbances in mineral metabolism and fractures in CKD patients are associated with increased morbidity and mortality. Appropriate identification and management of CKD-MBD is therefore critical to improving clinical outcome. Recent increases in understanding of the complex pathophysiology of CKD, which involves calcium, phosphate and magnesium balance, and is also influenced by vitamin D status and fibroblast growth factor (FGF)-23 production, should facilitate such improvement. Development of evidence-based recommendations about how best to use PTH is limited by considerable method-related variation in results, of up to 5-fold, as well as by lack of clarity about which PTH metabolites these methods recognise. This makes it difficult to compare PTH results from different studies and to develop common reference intervals and/or decision levels for treatment. The implications of these method-related differences for current clinical practice are reviewed here. Work being undertaken by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) to improve the comparability of PTH measurements worldwide is also described. [less ▲]

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See detailSiblings and the coming out process: a comparative case study
Haxhe, Stéphanie ULg; Cerezo, Alison; Bergfeld, Jeanette et al

in Journal of Homosexuality (2017), 64

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See detailHigh concordance of Pfdhfr and Pfdhps genotypes between matched peripheral and placental isolates of delivered women in Bobo-Dioulasso, Burkina Faso
Cissé, Mamoudou; Awandare, Gordon; Some, Fabrice et al

in Annals of Parasitology (2017), 63(2), 111-116

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps ... [more ▼]

Whether maternal peripheral parasites constitute a representative sample of the overall population infecting the individual, remains unknown in Burkina Faso. We therefore compared Pfdhfr and Pfdhps génotypes between matched peripheral and placental isolates. PCR-restriction fragment length polymorphism (PCR-RFLP) analysis of polymorphic codons of the Pfdhfr gene (51, 59, 108 and 164) and the Pfdhps gene (437 and 540) was performed in 18 matched peripheral and placental dried blood spots of delivered women in Bobo-Dioulasso. Both Pfdhfr and Pfdhps genes were successfully genotyped in 94.4% (17/18) of the matched samples. Only 8.8% (3/34) of génotypes were of the wild type, while 20.6% (7/34), 20.6% (7/34), 23.5% (8/34) and 26.5% (9/34) comprised one, two, three and four mutations, respectively. None of the samples carried both Pfdhfr I164L and Pfdhps K540E mutations. A concordance of 82.4% was observed in matched samples for both the Pfdhfr and Pfdhps genes. Setting placental allèles as the reference, a concordance of 100% was obtained with Pfdhfr mutation S108N, Pfdhfr mutation C59R+S108N, and Pfdhfr mutation N51I+C59R +S108N, respectively. Likewise, a concordance of 85.7% was observed with the Pfdhps mutation A437G. For epidemiological purposes, peripheral blood Pfdhfr and Pfdhps genotyping is sufficient for monitoring SP resistant molecular markers in pregnant women. [less ▲]

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See detailEtude comparative des profils de dissolution in vitro de quinine sulfate générique et princeps en utilisant la Chromatographie Liquide Haute Performance
Mbinze Kindenge, Jérémie ULg; Diallo, Tediane; Yemoa, Loconon ULg et al

in Médecine d'Afrique Noire (2017), 64

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses ... [more ▼]

Introduction : La quinine est une molécule préconisée pour le traitement du paludisme dans les régions où les souches de P. falciparum sont polyrésistantes. Face à l’importante utilisation de ses médicaments génériques d’une part, et au fléau des médicaments de qualité inférieure d’autre part, il devient plus que nécessaire d’appuyer les données des tests physico-chimiques par celles de dissolution in vitro dont l’évaluation et la comparaison des cinétiques permettra de prédire le comportement in vivo du principe actif et par conséquent l’efficacité du médicament générique. L’objectif de la présente étude est de réaliser une étude comparative de la cinétique de dissolution d’un princeps et d’un générique à base de quinine comprimé 300 mg commercialisés à Kinshasa. Matériels et méthodes : L’étude a été réalisée en utilisant trois milieux de pH différents (1,2 - 4,5 - 6,8) tels que recommandés par l’Agence Européenne de Médicament et en se servant d’un appareil de dissolution, tandis que l’équipement de chromatographie liquide à haute performance couplée à un détecteur à barrette de diodes a été utilisé pour la quantification. La méthode statistique fit factor a été appliquée pour comparer les résultats de dosage de la quinine dans les trois milieux tout en ayant évalué le biais à différents temps de dissolution. Résultats : Les différents échantillons de médicaments générique et princeps ont été conformes quant à l’identification et au dosage de la quinine, par contre leurs cinétiques de dissolution étaient non similaires. Discussion : Ceci pourrait avoir une influence sur l’efficacité du produit générique et la sécurité des consommateurs, dénotant l’importance d’examiner les profils de dissolution des génériques avant toute autorisation de mise sur le marché plus particulièrement dans les pays en voie de développement. [less ▲]

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See detailCartographie de la disponibilité en eau et en éléments nutritifs des stations forestières de Wallonie
Wampach, Florent ULg; Lisein, Jonathan; Cordier, Sophie ULg et al

in FORÊT.NATURE (2017), avril-mai-juin(143), 47-60

Grâce aux données cartographiques de plus en plus nombreuses et disponibles, il est maintenant possible d'analyser l'adéquation essence-station à l'échelle d'un massif ou d'un cantonnement. A l'échelle ... [more ▼]

Grâce aux données cartographiques de plus en plus nombreuses et disponibles, il est maintenant possible d'analyser l'adéquation essence-station à l'échelle d'un massif ou d'un cantonnement. A l'échelle plus locale, cette nouvelle cartographie constitue un outil d'aide à l'interprétation des stations pour les gestionnaires, forestiers ou naturalistes. [less ▲]

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See detailHypercalcemie par mutation inactivatrice du CYP24A1. Etude d'un cas et revue de la litterature.
Seidowsky, Alexandre; Villain, Cedric; Vilaine, Eve et al

in Néphrologie & Thérapeutique (2017)

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene ... [more ▼]

We present the case of a family whose members have high levels of serum calcium (hypercalcaemia) by loss of function of the enzyme vitamin D 24-hydroxylase due to bi-allelic mutations in the CYP24A1 gene: c.443 T>C (p.Leu148Pro) and c.1187 G>A (p.Arg396Gln). 24-VITD hydroxylase is a key player in regulating the circulating calcitriol, its tissue concentration and its biological effects. Transmission is recessive. The estimated prevalence of stones in the affected subjects is estimated between 10 and 15%. The loss of peripheral catabolism of vitamin D metabolites in patients with an inactivating mutation of CYP24A1 is responsible for persistent high levels of 1,25-dihydroxyvitamin D especially after sun exposure and a charge of native vitamin D. Although there are currently no recommendations (French review) on this subject, this disease should be suspected in association with recurrent calcium stones with nephrocalcinosis, and a calcitriol-dependent hypercalcaemia with adapted low parathyroid hormone levels. Resistance to corticosteroid therapy distinguishes it from other calcitriol-dependent hypercalcemia. A ratio of 25-hydroxyvitamin D/24.25 hydroxyvitamin D>50, is in favor of hypercalcemia with vitamin D deficiency 24-hydroxylase. Genetic analysis of CYP24A1 should be performed at the second step. The current therapeutic management includes the restriction native vitamin D supplementation and the limitation of sun exposure. Biological monitoring will be based on serum calcium control and modulation of parathyroid hormone concentrations. [less ▲]

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See detailThe ‘male escape hypothesis’: sex-biased metamorphosis in response to climatic drivers in a facultatively paedomorphic amphibian
Mathiron, Anthony; Lena, Jean-Paul; Baouch, Sarah et al

in Proceedings of the Royal Society B : Biological Sciences (2017), 284(1853), 20170176

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and ... [more ▼]

Paedomorphosis is a major evolutionary process that bypasses metamorphosis and allows reproduction in larvae. In newts and salamanders, it can be facultative with paedomorphs retaining gills and metamorphs dispersing. The evolution of these developmental processes is thought to have been driven by the costs and benefits of inhabiting aquatic versus terrestrial habitats. In this context, we aimed at testing the hypothesis that climatic drivers affect phenotypic transition and the difference across sexes because sex-ratio is biased in natural populations. Through a replicated laboratory experiment, we showed that paedomorphic palmate newts (Lissotriton helveticus) metamorphosed at a higher frequency when water availability decreased and metamorphosed earlier when temperature increased in these conditions. All responses were sex-biased, and males were more prone to change phenotype than females. Our work shows how climatic variables can affect facultative paedomorphosis and support theoretical models predicting life on land instead of in water. Moreover, because males metamorphose and leave water more often and earlier than females, these results, for the first time, give an experimental explanation for the rarity of male paedomorphosis (the ‘male escape hypothesis’) and suggest the importance of sex in the evolution of paedomorphosis versus metamorphosis. [less ▲]

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See detailClinical usefulness of bone turnover marker concentrations in osteoporosis.
Morris, H. A.; Eastell, R.; Jorgesen, N. R. et al

in Clinica Chimica Acta (2017), 467

Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the ... [more ▼]

Current evidence continues to support the potential for bone turnover markers (BTM) to provide clinically useful information particularly for monitoring the efficacy of osteoporosis treatment. Many of the limitations identified earlier remain, principally in regard to the relationship between BTM and incident fractures. Important data are now available on reference interval values for CTX and PINP across a range of geographic regions and for individual clinical assays. An apparent lack of comparability between current clinical assays for CTX has become evident indicating the possible limitations of combining such data for meta-analyses. Harmonization of units for reporting serum/plasma CTX (ng/L) and PINP (mug/L) is recommended. The development of international collaborations continues with an important initiative to combine BTM results from clinical trials in osteoporosis in a meta-analysis and an assay harmonization program are likely to be beneficial. It is possible that knowledge derived from clinical studies can further enhance fracture risk estimation tools with inclusion of BTM together with other independent risk factors. Further data of the relationships between the clinical assays for CTX and PINP as well as physiological and pre-analytical factors contributing to variability in BTM concentrations are required. [less ▲]

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See detailRetour sur le délit collectif
Kéfer, Fabienne ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), (16), 738-739

La nature réglementaire des infractions de non-paiement de rémunération ne les empêche pas de former un délit collectif

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See detailChemokine neutralization as an innovative therapeutic strategy for atopic dermatitis
Abboud, Dayana ULg; Hanson, Julien ULg

in Drug Discovery Today (2017), 22(4), 702-7011

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See detailDFT investigation of the reaction mechanism for the guanidine catalyzed ring-opening of cyclic carbonates by aromatic and alkyl-amines
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in RSC Advances (2017), 7(31), 18993-19001

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the ... [more ▼]

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the aromatic or aliphatic nature of the amine. The structural ability of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to simultaneously give and receive protons was demonstrated by a detailed mechanistic investigation. The bifunctional activity (base/H-bond donor) of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailMacro-nutrient concentrations in Antarctic pack ice: Overall patterns and overlooked processes
Fripiat, François ULg; Meiners, K.M.; Vancoppenolle, M. et al

in Elementa: Science of the Anthropocene (2017), 5(13),

Antarctic pack ice is inhabited by a diverse and active microbial community reliant on nutrients for growth. Seeking patterns and overlooked processes, we performed a large-scale compilation of macro ... [more ▼]

Antarctic pack ice is inhabited by a diverse and active microbial community reliant on nutrients for growth. Seeking patterns and overlooked processes, we performed a large-scale compilation of macro-nutrient data (hereafter termed nutrients) in Antarctic pack ice (306 ice-cores collected from 19 research cruises). Dissolved inorganic nitrogen and silicic acid concentrations change with time, as expected from a seasonally productive ecosystem. In winter, salinity-normalized nitrate and silicic acid concentrations (C*) in sea ice are close to seawater concentrations (Cw), indicating little or no biological activity. In spring, nitrate and silicic acid concentrations become partially depleted with respect to seawater (C* < Cw), commensurate with the seasonal build-up of ice microalgae promoted by increased insolation. Stronger and earlier nitrate than silicic acid consumption suggests that a significant fraction of the primary productivity in sea ice is sustained by flagellates. By both consuming and producing ammonium and nitrite, the microbial community maintains these nutrients at relatively low concentrations in spring. With the decrease in insolation beginning in late summer, dissolved inorganic nitrogen and silicic acid concentrations increase, indicating imbalance between their production (increasing or unchanged) and consumption (decreasing) in sea ice. Unlike the depleted concentrations of both nitrate and silicic acid from spring to summer, phosphate accumulates in sea ice (C* > Cw). The phosphate excess could be explained by a greater allocation to phosphorus-rich biomolecules during ice algal blooms coupled with convective loss of excess dissolved nitrogen, preferential remineralization of phosphorus, and/or phosphate adsorption onto metal-organic complexes. Ammonium also appears to be efficiently adsorbed onto organic matter, with likely consequences to nitrogen mobility and availability. This dataset supports the view that the sea ice microbial community is highly efficient at processing nutrients but with a dynamic quite different from that in oceanic surface waters calling for focused future investigations. [less ▲]

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See detailBenchmarking carbon fluxes of the ISIMIP2a biome models
Chang, Jinfeng; Ciais, Philippe; Wang, Xuhui et al

in Environmental Research Letters (2017), 12

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See detailOn-sky performance of the QACITS pointing control technique with the Keck/NIRC2 vortex coronagraph
Huby, Elsa ULg; Bottom, Michael; Femenia, Bruno et al

in Astronomy and Astrophysics (2017), 600

A vortex coronagraph is now available for high contrast observations with the Keck/NIRC2 instrument at L band. Reaching the optimal performance of the coronagraph requires fine control of the wavefront ... [more ▼]

A vortex coronagraph is now available for high contrast observations with the Keck/NIRC2 instrument at L band. Reaching the optimal performance of the coronagraph requires fine control of the wavefront incident on the phase mask. In particular, centering errors can lead to significant stellar light leakage that degrades the contrast performance and prevents the observation of faint planetary companions around the observed stars. It is thus critical to correct for the possible slow drift of the star image from the phase mask center, generally due to mechanical flexures induced by temperature and/or gravity field variation, or to misalignment between the optics that rotate in pupil tracking mode. A control loop based on the QACITS algorithm for the vortex coronagraph has thus been developed and deployed for the Keck/NIRC2 instrument. This algorithm executes the entire observing sequence, including the calibration steps, initial centering of the star on the vortex center and stabilisation during the acquisition of science frames. On-sky data show that the QACITS control loop stabilizes the position of the star image down to 2.4 mas rms at a frequency of about 0.02 Hz. However, the accuracy of the estimator is probably limited by a systematic error due to a misalignment of the Lyot stop with respect to the entrance pupil, estimated to be on the order of 4.5 mas. A method to reduce the amplitude of this bias down to 1 mas is proposed. The QACITS control loop has been successfully implemented and provides a robust method to center and stabilize the star image on the vortex mask. In addition, QACITS ensures a repeatable pointing quality and significantly improves the observing efficiency compared to manual operations. It is now routinely used for vortex coronagraph observations at Keck/NIRC2, providing contrast and angular resolution capabilities suited for exoplanet and disk imaging. [less ▲]

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See detailBlood Biomarkers in Idiopathic Pulmonary Fibrosis.
GUIOT, Julien ULg; Moermans, Catherine; Henket, Monique et al

in Lung (2017)

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of unknown origin whose incidence has been increasing over the latest decade partly as a consequence of population ... [more ▼]

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of unknown origin whose incidence has been increasing over the latest decade partly as a consequence of population ageing. New anti-fibrotic therapy including pirfenidone and nintedanib have now proven efficacy in slowing down the disease. Nevertheless, diagnosis and follow-up of IPF remain challenging. METHODS: This review examines the recent literature on potentially useful blood molecular and cellular biomarkers in IPF. Most of the proposed biomarkers belong to chemokines (IL-8, CCL18), proteases (MMP-1 and MMP-7), and growth factors (IGBPs) families. Circulating T cells and fibrocytes have also gained recent interest in that respect. Up to now, though several interesting candidates are profiling there has not been a single biomarker, which proved to be specific of the disease and predictive of the evolution (decline of pulmonary function test values, risk of acute exacerbation or mortality). CONCLUSION: Large scale multicentric studies are eagerly needed to confirm the utility of these biomarkers. [less ▲]

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See detailFrom Loose to Boxed Fragments and Back Again. Seriality and Archive in Chris Ware's ‘Building Stories’
Crucifix, Benoît ULg

in Journal of Graphic Novels and Comics (2017)

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to ... [more ▼]

This article focuses on the dynamics of seriality, archive and collection in Chris Ware's graphic novel “Building Stories”. It argues that the dispersed serialization of “Building Stories” is key to understand its box-of- comics format as well as its fragmented narrative structure. In a self-reflexive homage to the material history of comics, Ware's graphic novel indeed appears as an archive of its own serialization, foregrounding a process of collecting/dispersing fragments. [less ▲]

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See detailOLFM4, KNG1 and Sec24C identified by proteomics and immunohistochemistry as potential markers of early colorectal cancer stages
QUESADA-CALVO, Florence ULg; MASSOT, Charlotte ULg; Bertrand, Virginie ULg et al

in Clinical Proteomics (2017), 24(9),

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages ... [more ▼]

Abstract Background: Despite recent advances in colorectal cancer (CRC) diagnosis and population screening programs, the identification of patients with preneoplastic lesions or with early CRC stages remains challenging and is important for reducing CRC incidence and increasing patient’s survival. Methods: We analysed 76 colorectal tissue samples originated from early CRC stages, normal or inflamed mucosa by label-free proteomics. The characterisation of three selected biomarker candidates was performed by immunohisto‑ chemistry on an independent set of precancerous and cancerous lesions harbouring increasing CRC stages. Results: Out of 5258 proteins identified, we obtained 561 proteins with a significant differential distribution among groups of patients and controls. KNG1, OLFM4 and Sec24C distributions were validated in tissues and showed differ‑ ent expression levels especially in the two early CRC stages compared to normal and preneoplastic tissues. Conclusion: We highlighted three proteins that require further investigations to better characterise their role in early CRC carcinogenesis and their potential as early CRC markers. [less ▲]

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See detailPotential uses of pumped urban groundwater. A case study in Sant Adrià del Besòs (Spain)
Jurado Elices, Anna ULg; Vázquez-Suñé; Pujades, Estanislao ULg

in Hydrogeology Journal (2017)

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent ... [more ▼]

Urban groundwater has been over-exploited during the past, mainly for industrial uses, and it now tends to be reduced or abandoned due to pollution and/or changes in land use. The use and the subsequent disuse of groundwater resulted in rising water tables that damage underground structures (e.g., building basements and underground car parks and tunnels), leading to additional pumping in urban areas. This is the case of the underground parking lot of Sant Adrià del Besòs (NE Spain), where large amounts of urban groundwater are pumped to avoid seepage problems. The question that arises here is if this pumped groundwater can be used for other purposes (e.g., drinking water and urban irrigation) instead of wasting this valuable resource. To answer this question, it is necessary to quantify the groundwater recharge and to assess the evolution of ground-water quality in order to properly identify its potential uses. The limiting factor to define the uses of this resource is the groundwater quality because ammonium and some metals (iron and manganese) are present at high concentrations. Hence, further treatment would be needed to meet drinking water requirements. The pumped groundwater could also be used for supplying the ecological river flow and/or for mitigating seawater intrusion problems. Currently, only a small amount of this urban groundwater is used for cleaning public areas and watering public gardens. This situation highlighted the urgent need to manage this resource in a responsible and more efficient manner, especially in moments of high water demand such as drought periods. [less ▲]

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See detailLight, dark and the powerd that be: a hydroelectric project in Butembo
Geenen, Kristien ULg

in Canadian Journal of African Studies (2017), 51(1), 43-54

Despite its major importance in international trade, the city of Butembo in the North Kivu province of the Democratic Republic of Congo is deprived of such basic urban infrastructure as electricity ... [more ▼]

Despite its major importance in international trade, the city of Butembo in the North Kivu province of the Democratic Republic of Congo is deprived of such basic urban infrastructure as electricity. Private and public actors have attempted to bring power to the city, but their efforts have remained fruitless. Analysis of these failed projects to electrify the city offers a glimpse of local power relations. Why, rather than cooperating, do various local power holders counteract each other? Will gaining credit for bringing electric power to the city in turn yield political power over its future? With a special focus on a hydroelectric dam that was built but never functioned, this article sheds light on the way in which the citizens of Butembo relate to different bodies of authority. I argue that the hydroelectric dam gradually became a tool in a larger political strategy [less ▲]

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See detailIron minerals within specific microfossil morphospecies of the 1.88Ga Gunflint Formation
Lepot, kevin; Addad, Ahmed; Knoll, Andrew H et al

in Nature Communications (2017), DOI: 10.1038/ncomms14890

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See detailOrganocatalytic coupling of CO2 with a propargylic alcohol: a comprehensive study of the reaction mechanism combining in- situ ATR-IR spectroscopy and DFT calculations
Boyaval, Amélie ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

in ChemSusChem (2017), 10(6), 1241-1248

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR ... [more ▼]

The metal-free coupling of propargylic alcohols with carbon dioxide catalysed by guanidine derivatives was investigated in detail through the combination of online kinetic studies by in-situ ATR-IR spectroscopy and DFT calculations. Bicyclic guanidines, namely TBD and MTBD, are effective catalysts for the conversion of 2-methyl-3-butyn-2-ol to α-methylene cyclic carbonate and oxoalkyl acyclic carbonate under mild reaction conditions. The lower selectivity of TBD in comparison with MTBD towards the formation of α-methylene cyclic carbonate was elucidated from DFT calculations and is related to the bifunctional activity (base/H-bond donor) of TBD decreasing the Gibbs free energy of the reaction path for the formation of the acyclic carbonate. Introduction [less ▲]

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See detailOrganocatalytic coupling of CO2 with oxetane
Alves, Margot ULg; Grignard, Bruno ULg; Boyaval, Amélie ULg et al

in ChemSusChem (2017), 10(6), 1128-1138

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on ... [more ▼]

The organocatalytic coupling of CO2 with oxetanes is investigated under solvent-free conditions. The influence of the main reaction parameters (type of organocatalytic system, pressure and temperature) on the yield, the product formed and the selectivity of the reaction are discussed. An onium salt combined with a fluorinated alcohol promotes the efficient and selective organocatalytic synthesis of α,ω-hydroxyl oligocarbonates by coupling CO2 with oxetanes at 130 °C and at a CO2 pressure as low as 2 MPa. NMR characterizations were correlated with MALDI-ToF analyses for elucidating the structure of the oligomers. Online FTIR studies under pressure, NMR titrations and DFT calculations allowed an in-depth understanding of the reaction mechanism. Finally, CO2- based poly(carbonate-co-urethane)s were synthesized by step- growth polymerization of hydroxyl telechelic oligocarbonates with MDI. The organocatalytic system described in this paper constitutes an innovative sustainable route to the selective preparation of hydroxyl telechelic carbonates, of high interest for many applications, notably for the polyurethane business, especially for coatings or foams. [less ▲]

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See detailTranscriptome analysis of pancreatic cells across distant species highlights novel important regulator genes.
tarifeno-Saldiva, estefania; Lavergne, Arnaud ULg; Bernard, Alice et al

in BMC Biology (2017), 15

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the ... [more ▼]

Background Defining the transcriptome and the genetic pathways of pancreatic cells is of great interest for elucidating the molecular attributes of pancreas disorders such as diabetes and cancer. As the function of the different pancreatic cell types has been maintained during vertebrate evolution, the comparison of their transcriptomes across distant vertebrate species is a mean to pinpoint genes under strong evolutionary constrains due to their crucial function and which have preserved their selective expression in these pancreatic cell types. Results In this study, RNA-sequencing was performed on pancreatic alpha-, beta- and delta endocrine cells as well as the acinar and ductal exocrine cells isolated from adult zebrafish transgenic lines. Comparison of these transcriptomes identified many novel markers including transcription factors and signaling pathways components specific for each cell type. By performing interspecies comparisons, we identified hundreds of genes with conserved enriched expression in endocrine and exocrine cells among human, mouse and zebrafish. This list includes many genes known as crucial for pancreatic cell formation or function, but also pinpoints many factors whose pancreatic function is still unknown. A large set of endocrine-enriched genes can already be detected at early developmental stages as revealed by the transcriptomic profiling of embryonic endocrine cells, indicating a potential role in cell differentiation. The actual involvement of conserved endocrine genes in pancreatic cell differentiation was demonstrated in zebrafish for myt1b, whose invalidation leads to a reduction of alpha-cells, and for cdx4, selectively expressed in endocrine delta-cells and crucial for their specification. Intriguingly, comparison of the endocrine alpha- and beta-cell subtypes from human, mouse and zebrafish reveals a much lower conservation of the transcriptomic signatures for these two endocrine cell subtypes compared to the signatures of pan-endocrine and exocrine cells. These data suggest that the identity of the alpha- and beta-cells relies on a few key factors, corroborating numerous examples of inter-conversion between these two endocrine cell subtypes. Conclusion. This study highlights both evolutionary conserved and species-specific features that will help to unveil universal and fundamental regulatory pathways as well as pathways specific to human and laboratory animal models such as mouse and zebrafish. [less ▲]

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See detailSimultaneous synthesis and chemical functionalization of emulsion-templated porous polymers using nitroxide-terminated macromolecular surfactants
Mathieu, Kevin ULg; De Winter, Julien; Jérôme, Christine ULg et al

in Polymer Chemistry (2017), 8(11), 1850-1861

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in ... [more ▼]

The design of functional 3D macroporous monoliths has become a necessity for a wide range of applications. Traditional post-modification strategies of porous materials are efficient but often consist in tedious multi-steps processes. This work describes a straightforward macromolecular surfactant-assisted method for producing chemically functionalized macroporous polyHIPEs with interconnected structures. Accordingly, high internal phase emulsion-templated polymerizations were implemented in the presence of SG1-terminated amphiphilic copolymers prepared by nitroxide- mediated radical polymerization (NMP). The latter served as both stabilizers and functionalizing agents upon thermal activation of its terminal alkoxyamine and covalent anchoring of the released radical copolymer onto the walls of the scaffold. The effect of the polymerization temperature on the functionalization and openness of the final porous materials was explored. As a result, a range of open-cell styrene and acrylate-based polyHIPEs chemically grafted with PEO were obtained. Moreover, polyHIPEs were also decorated with alkyne-bearing PEO and subsequently modified via CuAAc click chemistry in order to demonstrate the potential of this macromolecular surfactants-assisted functionalization method. [less ▲]

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See detailUltimate strength of cylindrical shells with cutouts
Eui Lee, Sang; Sahin; Rigo, Philippe ULg et al

in Ships and Offshore Structures (2017)

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See detailKNN-MDR: a learning approach for improving interactions mapping performances in genome wide association studies
Abo Al Chamlat, Sinan ULg; Farnir, Frédéric ULg

in BMC Bioinformatics (2017), 18

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely ... [more ▼]

Background Finding epistatic interactions in large association studies like genome-wide association studies (GWAS) with the nowadays-available large volume of genomic data is a challenging and largely unsolved issue. Few previous studies could handle genome-wide data due to the intractable difficulties met in searching a combinatorial explosive search space and statistically evaluating epistatic interactions given a limited number of samples. Our work is a contribution to this field. We propose a novel approach combining K-Nearest Neighbors (KNN) and Multi Dimensional Reduction (MDR) methods for detecting gene-gene interactions as a possible alternative to existing algorithms, e especially in situations where the number of involved determinants is high. After describing the approach, a comparison of our method (KNN-MDR) to a set of the other most performing methods (i.e., MDR, BOOST, BHIT, MegaSNPHunter and AntEpiSeeker) is carried on to detect interactions using simulated data as well as real genome-wide data. Results Experimental results on both simulated data and real genome-wide data show that KNN-MDR has interesting properties in terms of accuracy and power, and that, in many cases, it significantly outperforms its recent competitors. Conclusions The presented methodology (KNN-MDR) is valuable in the context of loci and interactions mapping and can be seen as an interesting addition to the arsenal used in complex traits analyses. [less ▲]

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See detailInfluence of granular fraction and origin of recycled concrete aggregates on their properties
Zhao, Zengfeng ULg; Courard, Luc ULg; Michel, Frédéric ULg et al

in European Journal of Environmental and Civil Engineering (2017)

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of ... [more ▼]

Large quantities of construction and demolition wastes are produced each year. In order to make good use of recycled concrete aggregates (RCA) in concrete, it is very important to study the influence of the granular fraction and the origin of RCA on their properties. In this study, RCA from industrial produced blocks (RCA_Blocks) and slabs (RCA_Slabs) were crushed and then separated into four granular fractions (0/2, 2/6.3, 6.3/14, 14/20 mm). Each granular fraction of RCA was physically characterised. Real RCA from recycling plant were also used for comparison. The results showed that recycled sands offered significantly higher cement paste content (higher bound water content) than coarse recycled aggregates. The fine RCA had therefore a higher water absorption coefficient compared to coarser fractions of RCA. The water absorption of finer fraction of RCA could be extrapolated precisely from the relationship between water absorption and cement paste content (or bound water content) of three coarse fractions of RCA. The values of hardened cement paste content obtained for the RCA_Blocks were lower than those measured on the RCA_Slabs, which was due to a smaller amount of initial cement paste content in blocks. The results showed that RCA_Slabs were more angular than RCA_Blocks. [less ▲]

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See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULg; Foidart-Dessalle, Marguerite ULg; Tomasella, Marco ULg et al

in European Journal of Physical and Rehabilitation Medicine (2017)

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

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See detailRNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots.
Liu, Shi; Zainuddin, Ima M.; Vanderschuren, Hervé ULg et al

in Plant Molecular Biology (2017)

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava ... [more ▼]

Cassava (Manihot esculenta Crantz) is a major world crop, whose storage roots provide food for over 800 million throughout the humid tropics. Despite many advantages as a crop, the development of cassava is seriously constrained by the rapid post-harvest physiological deterioration (PPD) of its roots that occurs within 24-72 h of harvest, rendering the roots unpalatable and unmarketable. PPD limits cassava's marketing possibilities in countries that are undergoing increased development and urbanisation due to growing distances between farms and consumers. The inevitable wounding of the roots caused by harvesting triggers an oxidative burst that spreads throughout the cassava root, together with the accumulation of secondary metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abundant. Scopoletin oxidation yields a blue-black colour, which suggests its involvement in the discoloration observed during PPD. Feruloyl CoA 6'-hydroxylase is a controlling enzyme in the biosynthesis of scopoletin. The cassava genome contains a seven membered family of feruloyl CoA 6'-hydroxylase genes, four of which are expressed in the storage root and, of these, three were capable of functionally complementing Arabidopsis T-DNA insertion mutants in this gene. A RNA interference construct, designed to a highly conserved region of these genes, was used to transform cassava, where it significantly reduced feruloyl CoA 6'-hydroxylase gene expression, scopoletin accumulation and PPD symptom development. Collectively, our results provide evidence that scopoletin plays a major functional role in the development of PPD symptoms, rather than merely paralleling symptom development in the cassava storage root. [less ▲]

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See detailDevelopment of nuclear SNP markers for genetic tracking of Iroko, Milicia excelsa and Milicia regia
Blanc-Jolivet, Céline; Kersten, Birgit; Daïnou, Kasso ULg et al

in Conservation Genetics Resources (2017)

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs ... [more ▼]

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs at low densities in contrasting habitats such as rainforest and woodlands. Former studies using chloroplast and nuclear sequences, as well as nSSRs, revealed a strong differentiation within the species among West and Central African populations and the presence of three genetic groups in Central Africa (Daïnou et al. 2010, 2014). The genus Milicia also includes another species, M. regia, co-occurring with M. excelsa in West Africa. Both species can be identified genetically and morphologically (Daïnou et al. 2014), but identification is difficult in the field. Although the spatial genetic structure of the species is well described, it is mostly based on nSSRs. Despite their lower diversity, SNP markers provide several advantages including the uncomplicated standardization of data among laboratories and the easy, rapid and low-cost development of markers for large sets of loci. These features make SNPs the ideal markers for setting up genetic reference data for timber tracking (Blanc-Jolivet and Liesebach 2015; Degen et al. 2017; Jardine et al. 2016; Pakull et al. 2016). In this paper, we describe the development of a new set of nuclear SNPs on M. excelsa meant to be used for genetic timber tracking. [less ▲]

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See detailStatistics of localized phase slips in tunable width planar point contacts
Baumans, Xavier ULg; Zharinov, Vyacheslav; Raymenants, Eline et al

in Scientific Reports (2017), 7

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In ... [more ▼]

The main dissipation mechanism in superconducting nanowires arises from phase slips. Thus far, most of the studies focus on long nanowires where coexisting events appear randomly along the nanowire. In the present work we investigate highly confined phase slips at the contact point of two superconducting leads. Profiting from the high current crowding at this spot, we are able to shrink in-situ the nanoconstriction. This procedure allows us to investigate, in the very same sample, thermally activated phase slips and the probability density function of the switching current I sw needed to trigger an avalanche of events. Furthermore, for an applied current larger than I sw , we unveil the existence of two distinct thermal regimes. One corresponding to efficient heat removal where the constriction and bath temperatures remain close to each other, and another one in which the constriction temperature can be substantially larger than the bath temperature leading to the formation of a hot spot. Considering that the switching current distribution depends on the exact thermal properties of the sample, the identification of different thermal regimes is of utmost importance for properly interpreting the dissipation mechanisms in narrow point contacts. [less ▲]

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See detailUnderground pumped storage hydropower plants using open pit mines: How do groundwater exchanges influence the efficiency?
Pujades, Estanislao ULg; Orban, Philippe ULg; Bodeux, Sarah ULg et al

in Applied Energy (2017), 190

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of ... [more ▼]

Underground Pumped Storage Hydropower (UPSH) is a potential alternative to manage electricity production in flat regions. UPSH plants will interact with the surrounding porous medium through exchanges of groundwater. These exchanges may impact the surrounding aquifers, but they may also influence the efficiency of the pumps and turbines because affecting the head difference between the reservoirs. Despite the relevance for an accurate efficiency assessment, the influence of the groundwater exchanges has not been previously addressed. A numerical study of a synthetic case is presented to highlight the importance of considering the groundwater exchanges with the surrounding porous medium. The general methodology is designed in order to be further applied in the decision making of future UPSH plants introducing each case specific complexity. The underground reservoir of a hypothetical UPSH plant, which consists in an open pit mine, is considered and modelled together with the surrounding porous medium. Several scenarios with different characteristics are simulated and their results are compared in terms of (1) head difference between the upper and lower reservoirs and (2) efficiency by considering the theoretical performance curves of a pump and a turbine. The results show that the efficiency is improved when the groundwater exchanges increase. Thus, the highest efficiencies will be reached when (1) the underground reservoir is located in a transmissive porous medium and (2) the walls of the open pit mine do not constrain the groundwater exchanges (they are not waterproofed). However, a compromise must be found because the characteristics that increase the efficiency also increase the environmental impacts. Meaningful and reliable results are computed in relation to the characteristics of the intermittent and expected stops of UPSH plants. The frequency of pumping and injection must be considered to properly configure the pumps and turbines of future UPSH plants. If not, pumps and turbines could operate far from their best efficiency conditions. [less ▲]

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See detailModelling of organic Rankine cycle power systems in off-design conditions: an experimentally-validated comparative study
Dickes, Rémi ULg; Dumont, Olivier ULg; Daccord, Rémi et al

in Energy (2017), 123

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development ... [more ▼]

Because of environmental issues and the depletion of fossil fuels, the world energy sector is undergoing many changes toward increased sustainability. Among the many fields of research and development, power generation from low-grade heat sources is gaining interest and the organic Rankine cycle (ORC) is seen as one of the most promising technologies for such applications. In this paper, it is proposed to perform an experimentally-validated comparison of different modelling methods for the off-design simulation of ORC-based power systems. To this end, three types of modelling paradigms (namely a constant-efficiency method, a polynomial-based method and a semi-empirical method) are compared both in terms of their fitting and extrapolation capabilities. Post-processed measurements gathered on two experimental ORC facilities are used as reference for the models calibration and evaluation. The study is first applied at a component level (i.e. each component is analysed individually) and then extended to the characterization of the entire organic Rankine cycle power systems. Benefits and limi- tations of each modelling method are discussed. The results show that semi-empirical models are the most reliable for simulating the off-design working conditions of ORC systems, while constant-efficiency and polynomial-based models are both demonstrating lack of accuracy and/or robustness. [less ▲]

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See detailMacroH2A histone variants maintain nuclear organization and heterochromatin architecture.
Douet, Julien; Corujo, David; Malinverni, Roberto et al

in Journal of Cell Science (2017)

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated ... [more ▼]

Genetic loss-of-function studies in development, cancer and somatic cell reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin architecture. Specifically, we find that a substantial amount of macroH2A is associated with heterochromatic repeat sequences. We further identify macroH2A on sites of interstitial heterochromatin decorated by H3K9me3. Loss of macroH2A leads to major defects in nuclear organization including reduced nuclear circularity, disruption of nucleoli and a global loss of dense heterochromatin. Domains formed by repeat sequences when depleted of macroH2A are disorganized, expanded and fragmented and mildly re-expressed. On the molecular level we find that macroH2A is required for the interaction of repeat sequences with the nucleostructural protein Lamin B1. Taken together our results argue that a major function of macroH2A histone variants is to link nucleosome composition to higher order chromatin architecture. [less ▲]

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See detailBehavior of digital sequences through exotic numeration systems
Leroy, Julien ULg; Rigo, Michel ULg; Stipulanti, Manon ULg

in Electronic Journal of Combinatorics (2017), 24(1), 14436

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied ... [more ▼]

Many digital functions studied in the literature, e.g., the summatory function of the base-k sum-of-digits function, have a behavior showing some periodic fluctuation. Such functions are usually studied using techniques from analytic number theory or linear algebra. In this paper we develop a method based on exotic numeration systems and we apply it on two examples motivated by the study of generalized Pascal triangles and binomial coefficients of words. [less ▲]

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See detailStructure of Herbig AeBe disks at the milliarcsecond scale. A statistical survey in the H band using PIONIER-VLTI
Lazareff, B.; Berger, J.-P.; Kluska, J. et al

in Astronomy and Astrophysics (2017), 599

Context. It is now generally accepted that the near-infrared excess of Herbig AeBe stars originates in the dust of a circumstellar disk. Aims. The aims of this article are to infer the radial and vertical ... [more ▼]

Context. It is now generally accepted that the near-infrared excess of Herbig AeBe stars originates in the dust of a circumstellar disk. Aims. The aims of this article are to infer the radial and vertical structure of these disks at scales of order one au, and the properties of the dust grains. Methods. The program objects (51 in total) were observed with the H-band (1.6micron) PIONIER/VLTI interferometer. The largest baselines allowed us to resolve (at least partially) structures of a few tenths of an au at typical distances of a few hundred parsecs. Dedicated UBVRIJHK photometric measurements were also obtained. Spectral and 2D geometrical parameters are extracted via fits of a few simple models: ellipsoids and broadened rings with azimuthal modulation. Model bias is mitigated by parallel fits of physical disk models. Sample statistics were evaluated against similar statistics for the physical disk models to infer properties of the sample objects as a group. Results. We find that dust at the inner rim of the disk has a sublimation temperature Tsub~1800K. A ring morphology is confirmed for approximately half the resolved objects; these rings are wide delta_r>=0.5. A wide ring favors a rim that, on the star-facing side, looks more like a knife edge than a doughnut. The data are also compatible with a the combination of a narrow ring and an inner disk of unspecified nature inside the dust sublimation radius. The disk inner part has a thickness z/r~0.2, flaring to z/r~0.5 in the outer part. We confirm the known luminosity-radius relation; a simple physical model is consistent with both the mean luminosity-radius relation and the ring relative width; however, a significant spread around the mean relation is present. In some of the objects we find a halo component, fully resolved at the shortest interferometer spacing, that is related to the HAeBe class. [less ▲]

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See detailStrategic Points in Aquaponics
Junge, Ranka; König, Bettina; Villarroel, Morris et al

in Water (2017), 9(182),

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See detailLinking Forest Cover to Water Quality: A Multivariate Analysis of Large Monitoring Datasets
Brogna, Delphine; Michez, Adrien ULg; Jacobs, Sander et al

in Water (2017), 9(3), 176

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC ... [more ▼]

Forested catchments are generally assumed to provide higher quality water. However, this hypothesis must be validated in various contexts as interactions between multiple land use and land cover (LULC) types, ecological variables and water quality variables render this relationship highly complex. This paper applies a straightforward multivariate approach on a typical large monitoring dataset of a highly managed and densely populated area (Wallonia, Belgium; 10-year dataset), quantifying forest cover effects on nine physico-chemical water quality variables. Results show that forest cover explains about one third of the variability of water quality and is positively correlated with higher quality water. When controlling for spatial autocorrelation, forest cover still explains 9% of water quality. Unlike needle-leaved forest cover, broad-leaved forest cover presents an independent effect from ecological variables and explains independently 4.8% of water quality variability while it shares 5.8% with cropland cover. This study demonstrates clear independent effects of forest cover on water quality, and presents a method to tease out independent LULC effects from typical large multivariate monitoring datasets. Further research on explanatory variables, spatial distribution effects and water quality datasets could lead to effective strategies to mitigate pollution and reach legal targets. [less ▲]

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See detailBioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule
Thiry, Justine ULg; Kok, Miranda ULg; Collard, Laurence ULg et al

in European Journal of Pharmaceutical Sciences (2017), 99

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt ... [more ▼]

Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft copolymer abbreviated SOL) were produced using hot melt extrusion. Since ITZ possesses a water solubility of less than 1 ng/mL, the aim of this work was to enhance the aqueous solubility of ITZ, and thereby improve its bioavailability. The three formulations consisted of a simple SOL/ITZ amorphous solid dispersion (ASD), an optimized SOL/ITZ/AcDiSol® (super-disintegrant) ASD and an equimolar inclusion complex of ITZ in hydroxypropyl-β-cyclodextrin (substitution degree = 0.63, CD) with SOL. The three formulations were compared in vitro and in vivo to the marketed product Sporanox®. The in vitro enhancement of dissolution rate was evaluated using a biphasic dissolution test. In vitro dissolution results showed that all three formulations had a higher percentage of ITZ released than Sporanox® with the following ranking: SOL/ITZ/CD > SOL/ITZ/AcDiSol® > SOL/ITZ > Sporanox®. The bioavailability of these four formulations was evaluated in rats. The bioanalytical method was optimized so that only 10 μL of blood was withdrawn from the rats using specific volumetric absorptive microsampling devices. This enabled to keep the same rats during the whole study, which was in accordance with the Three Rs rules (reduction, refinement and replacement). Furthermore, this technique allowed the suppression of inter-individual variability. Higher Cmax and AUC were obtained after the administration of all three formulations compared to the levels after the use of Sporanox® as follows: SOL/ITZ/AcDiSol® > SOL/ITZ/CD > SOL/ITZ > Sporanox®. The inversion in the ranking between SOL/ITZ/CD and SOL/ITZ/AcDiSol® made impossible the establishment of an in vitro–vivo correlation. Indeed, very different release rates were obtained in vitro and in vivo for the two optimized formulations. These results suggest that ITZ would be protected inside the core of the SOL micelles even during the absorption step at the intestine, while some agents present in the intestinal fluids could displace ITZ from the hydrophobic cavity of CD by competition. [less ▲]

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See detailWASP-South transiting exoplanets: WASP-130b, WASP-131b, WASP-132b, WASP-139b, WASP-140b, WASP-141b & WASP-142b
Hellier, Coel; Anderson, D. R.; Collier Cameron, A. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with ... [more ▼]

We describe seven new exoplanets transiting stars of V = 10.1 to 12.4. WASP-130b is a "warm Jupiter" having an orbital period of 11.6 d, the longest yet found by WASP. It transits a V = 11.1, G6 star with [Fe/H] = +0.26. Warm Jupiters tend to have smaller radii than hot Jupiters, and WASP-130b is in line with this trend (1.23 Mjup; 0.89 Rjup). WASP-131b is a bloated Saturn-mass planet (0.27 Mjup; 1.22 Rjup). Its large scale height coupled with the V = 10.1 brightness of its host star make the planet a good target for atmospheric characterisation. WASP-132b is among the least irradiated and coolest of WASP planets, being in a 7.1-d orbit around a K4 star. It has a low mass and a modest radius (0.41 Mjup; 0.87 Rjup). The V = 12.4, [Fe/H] = +0.22 star shows a possible rotational modulation at 33 d. WASP-139b is the lowest-mass planet yet found by WASP, at 0.12 Mjup and 0.80 Rjup. It is a "super-Neptune" akin to HATS-7b and HATS-8b. It orbits a V = 12.4, [Fe/H] = +0.20, K0 star. The star appears to be anomalously dense, akin to HAT-P-11. WASP-140b is a 2.4-Mjup planet in a 2.2-d orbit that is both eccentric (e = 0.047) and with a grazing transit (b = 0.93) The timescale for tidal circularisation is likely to be the lowest of all known eccentric hot Jupiters. The planet's radius is large (1.4 Rjup), but uncertain owing to the grazing transit. The host star is a V = 11.1, [Fe/H] = +0.12, K0 dwarf showing a prominent 10.4-d rotational modulation. The dynamics of this system are worthy of further investigation. WASP-141b is a typical hot Jupiter, being a 2.7 Mjup, 1.2 Rjup planet in a 3.3-d orbit around a V = 12.4, [Fe/H] = +0.29, F9 star. WASP-142b is a typical bloated hot Jupiter (0.84 Mjup, 1.53 Rjup) in a 2.1-d orbit around a V = 12.3, [Fe/H] = +0.26, F8 star. [less ▲]

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See detailTwo massive rocky planets transiting a K-dwarf 6.5 parsecs away
Gillon, Michaël ULg; Demory, Brice-Olivier; Van Grootel, Valérie ULg et al

in Nature Astronomy (2017), 1

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of ... [more ▼]

HD 219134 is a K-dwarf star at a distance of 6.5 parsecs around which several low-mass planets were recently discovered[SUP]1,2[/SUP]. The Spitzer Space Telescope detected a transit of the innermost of these planets, HD 219134 b, whose mass and radius (4.5 M[SUB]⊕[/SUB] and 1.6 R[SUB]⊕[/SUB] respectively) are consistent with a rocky composition[SUP]1[/SUP]. Here, we report new high-precision time-series photometry of the star acquired with Spitzer revealing that the second innermost planet of the system, HD 219134c, is also transiting. A global analysis of the Spitzer transit light curves and the most up-to-date HARPS-N velocity data set yields mass and radius estimations of 4.74 ± 0.19 M[SUB]⊕[/SUB] and 1.602 ± 0.055 R[SUB]⊕[/SUB] for HD 219134 b, and of 4.36 ± 0.22 M[SUB]⊕[/SUB] and 1.511 ± 0.047 R[SUB]⊕[/SUB] for HD 219134 c. These values suggest rocky compositions for both planets. Thanks to the proximity and the small size of their host star (0.778 ± 0.005 R[SUB]⊙[/SUB])[SUP]3[/SUP], these two transiting exoplanets — the nearest to the Earth yet found — are well suited for a detailed characterization (for example, precision of a few per cent on mass and radius, and constraints on the atmospheric properties) that could give important constraints on the nature and formation mechanism of the ubiquitous short-period planets of a few Earth masses. [less ▲]

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See detailReconnaissance of the TRAPPIST-1 exoplanet system in the Lyman-α line
Bourrier, V.; Ehrenreich, D.; Wheatley, P. J. et al

in Astronomy and Astrophysics (2017), 599

The TRAPPIST-1 system offers the opportunity to characterize terrestrial, potentially habitable planets orbiting a nearby ultracool dwarf star. We performed a four-orbit reconnaissance with the Space ... [more ▼]

The TRAPPIST-1 system offers the opportunity to characterize terrestrial, potentially habitable planets orbiting a nearby ultracool dwarf star. We performed a four-orbit reconnaissance with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope to study the stellar emission at Lyman-α, to assess the presence of hydrogen exospheres around the two inner planets, and to determine their UV irradiation. We detect the Lyman-α line of TRAPPIST-1, making it the coldest exoplanet host star for which this line has been measured. We reconstruct the intrinsic line profile, showing that it lacks broad wings and is much fainter than expected from the stellar X-ray emission. TRAPPIST-1 has a similar X-ray emission as Proxima Cen but a much lower Ly-α emission. This suggests that TRAPPIST-1 chromosphere is only moderately active compared to its transition region and corona. We estimated the atmospheric mass loss rates for all planets, and found that despite a moderate extreme UV emission the total XUV irradiation could be strong enough to strip the atmospheres of the inner planets in a few billions years. We detect marginal flux decreases at the times of TRAPPIST-1b and c transits, which might originate from stellar activity, but could also hint at the presence of extended hydrogen exospheres. Understanding the origin of these Lyman-α variations will be crucial in assessing the atmospheric stability and potential habitability of the TRAPPIST-1 planets. [less ▲]

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See detailPerspectives for observing hot massive stars with XMM-Newton in the years 2017-2027
Rauw, Grégor ULg

in Astronomische Nachrichten (2017), 338

XMM-Newton has deeply changed our picture of X-ray emission of hot, massive stars. High-resolution X-ray spectroscopy as well as monitoring of these objects helped us gain a deeper insight into the ... [more ▼]

XMM-Newton has deeply changed our picture of X-ray emission of hot, massive stars. High-resolution X-ray spectroscopy as well as monitoring of these objects helped us gain a deeper insight into the physics of single massive stars with or without magnetic fields, as well as of massive binary systems, where the stellar winds of both stars interact. These observations also revealed a number of previously unexpected features that challenge our understanding of the dynamics of the stellar winds of massive stars. I briefly summarize the results obtained over the past 15 years and highlight the perspectives for the next decade. It is anticipated that coordinated (X-ray and optical or UV) monitoring and time-critical observations of either single or binary massive stars will become the most important topics in this field over the coming years. Synergies with existing or forthcoming X-ray observatories (NuSTAR, Swift, eROSITA) will also play a major role and will further enhance the importance of XMM-Newton in our quest for understanding the physics of hot, massive stars. [less ▲]

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See detailPouvoir politique et audace des juges
Grandjean, Geoffrey ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), (1), 231-237

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See detailH0LiCOW. VI. Testing the fidelity of lensed quasar host galaxy reconstruction
Ding, Xuheng; Liao, Kai; Treu, Tommaso et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co ... [more ▼]

The empirical correlation between the mass of a supermassive black hole (M_BH) and its host galaxy properties is widely considered to be an evidence of their co-evolution. A powerful way to test the co-evolution scenario and learn about the feedback processes linking galaxies and nuclear activity is to measure these correlations as a function of redshift. Unfortunately, currently M_BH can only be estimated in active galaxies at cosmological distances. At these distances, bright active galactic nuclei (AGNs) can outshine the host galaxy, making it extremely difficult to measure the host's luminosity. Strongly lensed AGNs provide in principle a great opportunity to improve the sensitivity and accuracy of the host galaxy luminosity measurements as the host galaxy is magnified and more easily separated from the point source, provided the lens model is sufficiently accurate. In order to measure the M_BH-L correlation with strong lensing, it is necessary to ensure that the lens modelling is accurate, and that the host galaxy luminosity can be recovered to at least a precision and accuracy better than that of the typical M_BH measurement. We carry out extensive and realistic simulations of deep Hubble Space Telescope observations of lensed AGNs obtained by our collaboration. We show that the host galaxy luminosity can be recovered with better accuracy and precision than the typical uncertainty in M_BH(˜0.5 dex) for hosts as faint as 2-4 mag dimmer than the AGN itself. Our simulations will be used to estimate bias and uncertainties in the actual measurements to be presented in a future paper. [less ▲]

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See detailLacustrine clay mineral assemblages as a proxy for land-use and climate changes over the last 4 kyr: The Amik Lake case study, Southern Turkey
El Ouahabi, Meriam ULg; Hubert, Aurelia ULg; Fagel, Nathalie ULg

in Quaternary International (2017), 1/15

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital ... [more ▼]

Lake sediments are sensitive to landscape changes and most of these changes seem to be modulated by land-use (anthropogenic factors) coupled to palaeoenvironmental/palaeoclimatic changes. In its detrital fraction, the lacustrine sediments record the history of soil erosion within its catchment via the inputs of clays and others detrital products. Within a Mediterranean context, the study investigates the upper sediments infilling the central part of the Amik basin in southern Turkey. This tectonic basin was occupied and exploited by modern human at least since 6000-7000 BC. We focus on the clay mineralogy (x-ray diffraction on oriented aggregates) and magnetic susceptibility measurements (Bartington) of the sedimentary record in the area over the last 4000 years, to assess environmental changes in relation with the different land uses and/or weathering during the successive Bronze, Iron, Roman, Islamic/Ottoman and Modern civilizations. The clay fraction of Amik Lake sediments comprises smectite, kaolinite, illite, chlorite and chlorite/smectite mixed layers that are the inherited clay phases. A relative change in abundance and crystallinity and chemistry of illite attests that environmental conditions evolved in the Amik Plain from the Bronze to Modern Age in relation with climates and/or land-use changes. The history of the Amik Lake reveals different soil erosion episode. The most intense erosion phase occurred during the Bronze/Iron Ages as indicated by the clay and magnetic susceptibility proxies. The Roman period was an exceptional period with soil erosion products arriving from the watershed, probably due the water channelization. A reduction of soil erosion occurred during the post Roman period until nowadays. Significant pedogenesis transformations are evidenced, especially during the Islamic/Ottoman periods suggesting intense chemical weathering conditions related to climate change. [less ▲]

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See detailH0LiCOW - IV. Lens mass model of HE 0435-1223 and blind measurement of its time-delay distance for cosmology
Wong, Kenneth C.; Suyu, Sherry H.; Auger, Matthew W. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

Strong gravitational lenses with measured time delays between the multiple images allow a direct measurement of the time-delay distance to the lens, and thus a measure of cosmological parameters ... [more ▼]

Strong gravitational lenses with measured time delays between the multiple images allow a direct measurement of the time-delay distance to the lens, and thus a measure of cosmological parameters, particularly the Hubble constant, H[SUB]0[/SUB]. We present a blind lens model analysis of the quadruply imaged quasar lens HE 0435-1223 using deep Hubble Space Telescope imaging, updated time-delay measurements from the COSmological MOnitoring of GRAvItational Lenses (COSMOGRAIL), a measurement of the velocity dispersion of the lens galaxy based on Keck data, and a characterization of the mass distribution along the line of sight. HE 0435-1223 is the third lens analysed as a part of the H[SUB]0[/SUB] Lenses in COSMOGRAIL's Wellspring (H0LiCOW) project. We account for various sources of systematic uncertainty, including the detailed treatment of nearby perturbers, the parametrization of the galaxy light and mass profile, and the regions used for lens modelling. We constrain the effective time-delay distance to be D_{Δ t}= 2612_{-191}^{+208} Mpc, a precision of 7.6 per cent. From HE 0435-1223 alone, we infer a Hubble constant of H[SUB]0[/SUB] = 73.1_{-6.0}^{+5.7} km s^{-1 Mpc^{-1}} assuming a flat ΛCDM cosmology. The cosmographic inference based on the three lenses analysed by H0LiCOW to date is presented in a companion paper (H0LiCOW Paper V). [less ▲]

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See detailH0LiCOW - V. New COSMOGRAIL time delays of HE 0435-1223: H0 to 3.8 per cent precision from strong lensing in a flat ΛCDM model
Bonvin, V.; Courbin, F.; Suyu, S. H. et al

in Monthly Notices of the Royal Astronomical Society (2017), 465

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time ... [more ▼]

We present a new measurement of the Hubble Constant H[SUB]0[/SUB] and other cosmological parameters based on the joint analysis of three multiply imaged quasar systems with measured gravitational time delays. First, we measure the time delay of HE 0435-1223 from 13-yr light curves obtained as part of the COSMOGRAIL project. Companion papers detail the modelling of the main deflectors and line-of-sight effects, and how these data are combined to determine the time-delay distance of HE 0435-1223. Crucially, the measurements are carried out blindly with respect to cosmological parameters in order to avoid confirmation bias. We then combine the time-delay distance of HE 0435-1223 with previous measurements from systems B1608+656 and RXJ1131-1231 to create a Time Delay Strong Lensing probe (TDSL). In flat Λ cold dark matter (ΛCDM) with free matter and energy density, we find H[SUB]0[/SUB] =71.9^{+2.4}_{-3.0} {km s^{-1} Mpc^{-1}} and Ω _{Λ }=0.62^{+0.24}_{-0.35}. This measurement is completely independent of, and in agreement with, the local distance ladder measurements of H[SUB]0[/SUB]. We explore more general cosmological models combining TDSL with other probes, illustrating its power to break degeneracies inherent to other methods. The joint constraints from TDSL and Planck are H[SUB]0[/SUB] = 69.2_{-2.2}^{+1.4} {km s^{-1} Mpc^{-1}}, Ω _{Λ }=0.70_{-0.01}^{+0.01} and Ω _k=0.003_{-0.006}^{+0.004} in open ΛCDM and H[SUB]0[/SUB] =79.0_{-4.2}^{+4.4} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.02} and w=-1.38_{-0.16}^{+0.14} in flat wCDM. In combination with Planck and baryon acoustic oscillation data, when relaxing the constraints on the numbers of relativistic species we find N[SUB]eff[/SUB] = 3.34_{-0.21}^{+0.21} in N[SUB]eff[/SUB]ΛCDM and when relaxing the total mass of neutrinos we find Σm[SUB]ν[/SUB] ≤ 0.182 eV in m[SUB]ν[/SUB]ΛCDM. Finally, in an open wCDM in combination with Planck and cosmic microwave background lensing, we find H[SUB]0[/SUB] =77.9_{-4.2}^{+5.0} {km s^{-1} Mpc^{-1}}, Ω _de=0.77_{-0.03}^{+0.03}, Ω _k=-0.003_{-0.004}^{+0.004} and w=-1.37_{-0.23}^{+0.18}. [less ▲]

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See detailEvolutionary status of the Of?p star HD 148937 and of its surrounding nebula NGC 6164/5
Mahy, Laurent ULg; Hutsemekers, Damien ULg; Nazé, Yaël ULg et al

in Astronomy and Astrophysics (2017), 599(A61), 17

<BR /> Aims: The magnetic star HD 148937 is the only Galactic Of?p star surrounded by a nebula. The structure of this nebula is particularly complex and is composed, from the center out outwards, of a ... [more ▼]

<BR /> Aims: The magnetic star HD 148937 is the only Galactic Of?p star surrounded by a nebula. The structure of this nebula is particularly complex and is composed, from the center out outwards, of a close bipolar ejecta nebula (NGC 6164/5), an ellipsoidal wind-blown shell, and a spherically symmetric Strömgren sphere. The exact formation process of this nebula and its precise relation to the star's evolution remain unknown. <BR /> Methods: We analyzed infrared Spitzer IRS and far-infrared Herschel/PACS observations of the NGC 6164/5 nebula. The Herschel imaging allowed us to constrain the global morphology of the nebula. We also combined the infrared spectra with optical spectra of the central star to constrain its evolutionary status. We used these data to derive the abundances in the ejected material. To relate this information to the evolutionary status of the star, we also determined the fundamental parameters of HD 148937 using the CMFGEN atmosphere code. <BR /> Results: The Hα image displays a bipolar or "8"-shaped ionized nebula, whilst the infrared images show dust to be more concentrated around the central object. We determine nebular abundance ratios of N/O = 1.06 close to the star, and N/O = 1.54 in the bright lobe constituting NGC 6164. Interestingly, the parts of the nebula located further from HD 148937 appear more enriched in stellar material than the part located closer to the star. Evolutionary tracks suggest that these ejecta have occured 1.2-1.3 and 0.6 Myr ago, respectively. In addition, we derive abundances of argon for the nebula compatible with the solar values and we find a depletion of neon and sulfur. The combined analyses of the known kinematics and of the new abundances of the nebula suggest either a helical morphology for the nebula, possibly linked to the magnetic geometry, or the occurrence of a binary merger. Herschel is an ESA space observatory with science instruments provided by European-led Principal Investigator consortia and with important participation from NASA.Based in part on observations collected at the European Southern Observatory, in Chile. [less ▲]

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See detailPhotosynthetic trichomes contain a specific Rubisco with a modified pH9 dependent activity
Laterre, Raphaëlle; Pottier, Mathieu; Remacle, Claire ULg et al

in Plant Physiology (2017)

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See detailBioreducible cross-linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells
Gulfam, Muhammad ULg; Matini, Teresa; Monteiro, Patrícia F et al

in Biomaterials Science (2017), 5(3), 532-550

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we ... [more ▼]

Polymer micelles have emerged as promising carriers for controlled release applications, however, several limitations of micelle-based drug delivery have also been reported. To address these issues, we have synthesized a functional biodegradable and cytocompatible block copolymer based on methoxypoly (ethyleneglycol)-b-poly(ε-caprolactone-co-α-azido-ε-caprolactone) (mPEG-b-poly(εCL-co-αN3εCL)) as a precursor of reduction sensitive core-crosslinked micelles. The synthesized polymer was formulated as micelles using a dialysis method and loaded with the anti-inflammatory and anti-cancer drug metho- trexate (MTX). The micellar cores were subsequently crosslinked at their pendent azides by a redox- responsive bis(alkyne). The size distributions and morphology of the polymer micelles were assessed using dynamic light scattering (DLS) and transmission electron microscopy, and drug release assays were performed under simplified (serum free) physiological and reductive conditions. Cellular uptake studies in human breast cancer cells were performed using Oregon-green loaded core-crosslinked micelles. The MTX-loaded core-crosslinked micelles were assessed for their effects on metabolic activity in human breast cancer (MCF-7) cells by evaluating the reduction of the dye MTT 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide. The apoptosis inducing potential of MTX-loaded core-crosslinked micelles was analysed using Hoechst/propidium iodide (PI) and annexin-V/PI assays. The data from these experi- ments indicated that drug release from these cross-linked micelles can be controlled and that the redox- responsive micelles are more effective carriers for MTX than non-crosslinked analogues and the free drug in the cell-lines tested. [less ▲]

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See detailLes peuplements à bouleau en forêt wallonne: reflet de la sylviculture du 20ème siècle
Dubois, Héloïse ULg; Latte, Nicolas ULg; Claessens, Hugues ULg

in FORÊT.NATURE (2017), 142

Le bouleau est présent sous des formes diverses dans nos forêts. La place qu’il occupe en forêt wallonne est souvent le reflet d’une méconnaissance et du peu d’estime que lui portaient les sylviculteurs ... [more ▼]

Le bouleau est présent sous des formes diverses dans nos forêts. La place qu’il occupe en forêt wallonne est souvent le reflet d’une méconnaissance et du peu d’estime que lui portaient les sylviculteurs. Par une typologie des peuplements, l’article fait le tri parmi les contextes où se trouve le bouleau et discute de leurs potentialités sylvicoles dans un contexte changeant qui pourrait faire la part belle à cette essence vigoureuse et aux atouts variés. [less ▲]

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See detailMagnetic reconnection during steady magnetospheric convection and other magnetospheric modes
Hubert, Benoît ULg; Gérard, Jean-Claude ULg; Milan, Steve E. et al

in Annales Geophysicae (2017), 35

We use remote sensing of the proton aurora with the IMAGE-FUV SI12 (Imager for Magnetopause to Aurora Global Exploration-Far Ultraviolet-Spectrographic Imaging at 121.8 nm) instrument and radar ... [more ▼]

We use remote sensing of the proton aurora with the IMAGE-FUV SI12 (Imager for Magnetopause to Aurora Global Exploration-Far Ultraviolet-Spectrographic Imaging at 121.8 nm) instrument and radar measurements of the ionospheric convection from the SuperDARN (Super Dual Aurora Radar Network) facility to estimate the open magnetic flux in the Earth's magnetosphere and the reconnection rates at the dayside magnetopause and in the magnetotail during intervals of steady magnetospheric convection (SMC). We find that SMC intervals occur with relatively high open magnetic flux (average ˜ 0.745 GWb, standard deviation ˜ 0.16 GWb), which is often found to be nearly steady, when the magnetic flux opening and closure rates approximately balance around 55 kV on average, with a standard deviation of 21 kV. We find that the residence timescale of open magnetic flux, defined as the ratio between the open magnetospheric flux and the flux closure rate, is roughly 4 h during SMCs. Interestingly, this number is approximately what can be deduced from the discussion of the length of the tail published by Dungey (1965), assuming a solar wind speed of ˜ 450 km s[SUP]-1[/SUP]. We also infer an enhanced convection velocity in the tail, driving open magnetic flux to the nightside reconnection site. We compare our results with previously published studies in order to identify different magnetospheric modes. These are ordered by increasing open magnetic flux and reconnection rate as quiet conditions, SMCs, substorms (with an important overlap between these last two) and sawtooth intervals. [less ▲]

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See detailFactors to be considered to perform a kinematic evaluation of the tennis serve
Tubez, François ULg; Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg et al

in Journal of Medecine and Science in Tennis (2017), 22

With the 2D video cameras and later the appearance of 3D measurement methods, the tennis serve has been increasingly studied. In order to improve the biomechanical evaluation of the tennis serve. Our goal ... [more ▼]

With the 2D video cameras and later the appearance of 3D measurement methods, the tennis serve has been increasingly studied. In order to improve the biomechanical evaluation of the tennis serve. Our goal is to provide a comprehensive view of the major factors of an evaluation protocol. [less ▲]

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See detailCouper et coller ? Une anecdote dans les manuscrits avestiques : l’exemple de K5 et K6
Ferrer-Losilla, Joan Josep ULg

in Estudios Iranios y Turanios. fәrā amәṣ̌ā spәṇtā gāθā̊ gə̄uruuāin Homenaje a Helmut Humbach en su 95º aniversario (2017), 3(1), 59-66

The present paper analyses an anecdotic case of “copy and paste” between two manuscripts belonging to two different lines of the Zoroastrian manuscript transmission: the Pahlavi exegetical (ms. K5) and ... [more ▼]

The present paper analyses an anecdotic case of “copy and paste” between two manuscripts belonging to two different lines of the Zoroastrian manuscript transmission: the Pahlavi exegetical (ms. K5) and the Sanskrit exegetical (ms. K6). I have found that a lost fragment of K5 is pasted, in fact, in K6 in a context hardly comprehensible. [less ▲]

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See detailComment les vidéastes gagnent-ils leur vie sur Youtube ?
Krywicki, Boris ULg

in Culture, le Magazine Culturel de l'Université de Liège (2017)

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See detailUltrasonic spray pyrolysis as a processing route for templated electrochromic tungsten oxide films
Chatzikyriakou, Dafni ULg; Maho, Anthony ULg; Cloots, Rudi ULg et al

in Microporous and Mesoporous Materials (2017), 240

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See detailArtemisia campestris L.:Ethnomedical, phytochemical and pharmacological review
Dib, Ikram; Angenot, Luc ULg; Ziyyat, Abderrahim et al

in Journal of Herbal Medicine (2017), 7(1), 1-10

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic ... [more ▼]

Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic, antidiabetic, antihypertensive, emmenagogue, antivenom, and to treat digestive and cutaneous problems. an exhaustive bibliographic research of this plant has been carried out by means of scientific engines and databases like Google scholar, PubMed, Sciencedirect and sciFinder; as a result, it has been found that this herb possesses a rich phytochemical content and a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic , antivenom and antitumor effects. In an aim to highlight the importance of A. campestris L., this review has been established by discussing its ethnomedicinal, morphological, ecological, phytochemical, pharmacological and toxicological studies. [less ▲]

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See detailFlux penetration in a superconducting film partially capped with a conducting layer
Brisbois, Jérémy ULg; Gladilin, V. N.; Tempere, J. et al

in Physical Review B (2017), 95

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides ... [more ▼]

The influence of a conducting layer on the magnetic flux penetration in a superconducting Nb film is studied by magneto-optical imaging. The metallic layer partially covering the superconductor provides an additional velocity-dependent damping mechanism for the flux motion that helps protecting the superconducting state when thermomagnetic instabilities develop. If the flux advances with a velocity slower than w = 2/µ0σt, where σ is the cap layer conductivity and t is its thickness, the flux penetration remains unaffected, whereas for incoming flux moving faster than w, the metallic layer becomes an active screening shield. When the metallic layer is replaced by a perfect conductor, it is expected that the flux braking effect will occur for all flux velocities. We demonstrate this effect by investigating Nb samples with a thickness step. Some of the observed features, namely the deflection and the branching of the flux trajectories at the border of the thick centre, as well as the favoured flux penetration at the indentation, are reproduced by time-dependent Ginzburg-Landau simulations. [less ▲]

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See detailErnst Mach, psychologue de la forme ?
Zincq, Aurélien ULg

in Philosophie (2017), 133

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See detailLe projet sémiologique de Barthes dans la revue Communications
Lorent, Fanny ULg; Franck, Thomas ULg

in Revue Roland Barthes (2017), 3

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See detailLésions mixtes des mâchoires, radio-opaques et radio-transparentes
MILICEVIC, Mladen ULg

in Revue Médicale de Liège (2017), 72(3), 151-155

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre ... [more ▼]

Les Lésions néoplasiques et non néoplasiques des mâchoires sont généralement classifiées comme radio-opaques ou radio-transparentes, odontogènes ou non odontogènes. Toutefois, il existe un nombre significatif de pathologies qui peuvent être classifiées comme étant mixtes ou qui, au départ, sont radio-transparentes et deviennent ultérieurement radio-opaques ou mixtes. certaines pathologies s'expriment en différents stades de développement qui sont radio-transparents, radio-opaques ou mixtes. Le but de cet article est d'apporter une meilleure compréhension de l'imagerie de ces lésions, fondée sur une revue de la littérature, illustrée par des images de cas cliniques personnels. [less ▲]

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See detailNutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
Beaudart, Charlotte ULg; Dawson, A.; Shaw, S. C. et al

in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2017), 28(6), 1817-33

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise ... [more ▼]

This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be limited. INTRODUCTION: In 2013, Denison et al. conducted a systematic review including 17 randomized controlled trials (RCTs) to explore the effect of combined exercise and nutrition intervention to improve muscle mass, muscle strength, or physical performance in older people. They concluded that further studies were needed to provide evidence upon which public health and clinical recommendations could be based. The purpose of the present work was to update the prior systematic review and include studies published up to October 2015. METHODS: Using the electronic databases MEDLINE and EMBASE, we identified RCTs which assessed the combined effect of exercise training and nutritional supplementation on muscle strength, muscle mass, or physical performance in subjects aged 60 years and over. Study selection and data extraction were performed by two independent reviewers. RESULTS: The search strategy identified 21 additional RCTs giving a total of 37 RCTs. Studies were heterogeneous in terms of protocols for physical exercise and dietary supplementation (proteins, essential amino acids, creatine, beta-hydroxy-beta-methylbuthyrate, vitamin D, multi-nutrients, or other). In 79% of the studies (27/34 RCTs), muscle mass increased with exercise but an additional effect of nutrition was only found in 8 RCTs (23.5%). Muscle strength increased in 82.8% of the studies (29/35 RCTs) following exercise intervention, and dietary supplementation showed additional benefits in only a small number of studies (8/35 RCTS, 22.8%). Finally, the majority of studies showed an increase of physical performance following exercise intervention (26/28 RCTs, 92.8%) but interaction with nutrition supplementation was only found in 14.3% of these studies (4/28 RCTs). CONCLUSION: Physical exercise has a positive impact on muscle mass and muscle function in healthy subjects aged 60 years and older. The biggest effect of exercise intervention, of any type, has been seen on physical performance (gait speed, chair rising test, balance, SPPB test, etc.). We observed huge variations in regard to the dietary supplementation protocols. Based on the included studies, mainly performed on well-nourished subjects, the interactive effect of dietary supplementation on muscle function appears limited. [less ▲]

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See detailPublic Health impact and economic evaluation of vitamin D-fortified dairy products for fracture prevention in France.
HILIGSMANN, M.; BURLET, N.; FARDELLONE, P. et al

in Osteoporosis International (2017), 28(3), 833-840

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French ... [more ▼]

Summary: The recommended intake of vitamin D-fortified dairy products can substantially decrease the burden of osteoporotic fractures and seems an economically beneficial strategy in the general French population aged over 60 years. Introduction: This study aims to assess the public health and economic impact of vitamin D-fortified dairy products in the general French population aged over 60 years. Methods: We estimated the lifetime health impacts expressed in number of fractures prevented, life years gained, and quality-adjusted life years (QALY) gained of the recommended intake of dairy products in the general French population over 60 years for 1 year (2015). A validated microsimulation model was used to simulate three age cohorts for both women and men (60–69, 70–79, and >80 years). The incremental cost per QALY gained of vitamin D-fortified dairy products compared to the absence of appropriate intake was estimated in different populations, assuming the cost of two dairy products per day in base case. Results: The total lifetime number of fractures decreased by 64,932 for the recommended intake of dairy products in the general population over 60 years, of which 46,472 and 18,460 occurred in women and men, respectively. In particular, 15,087 and 4413 hip fractures could be prevented in women and men. Vitamin D-fortified dairy products also resulted in 32,569 QALYs and 29,169 life years gained. The cost per QALY gained of appropriate dairy intake was estimated at €58,244 and fall below a threshold of €30,000 per QALY gained in women over 70 years and in men over 80 years. Conclusion: Vitamin D-fortified dairy products have the potential to substantially reduce the burden of osteoporotic fractures in France and seem an economically beneficial strategy, especially in the general population aged above 70 years. [less ▲]

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See detailComparison of local outliers detection techniques in spatial multivariate data
Ernst, Marie ULg; Haesbroeck, Gentiane ULg

in Data Mining & Knowledge Discovery (2017), 31(2), 371399

Outlier detection techniques in spatial data should allow to identify two types of outliers: global and local ones. Local outliers typically have non-spatial attributes that strongly differ from those ... [more ▼]

Outlier detection techniques in spatial data should allow to identify two types of outliers: global and local ones. Local outliers typically have non-spatial attributes that strongly differ from those observed on their neighbors. Detecting local outliers requires to be able to work locally, on neighborhoods, in order to take into account the spatial dependence between the statistical units under consideration, even though the outlyingness is usually measured on the non-spatial variables. Many procedures have been outlined in the literature, but their number reduces when one wants to deal with multivariate non-spatial attributes. In this paper, focus is on the multivariate context. A review of existing procedures is done. A new approach, based on a two-step improvement of an existing one, is also designed and compared with the benchmarked methods by means of examples and simulations. [less ▲]

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See detailGeneration of High-Amylose Rice through CRISPR/Cas9-Mediated Targeted Mutagenesis of Starch Branching Enzymes
Sun, Yongwei ULg; Xia, Lanqin; Francis, Frédéric ULg et al

in Frontiers in Plant Science (2017), 8

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching ... [more ▼]

Cereals high in amylose content (AC) and resistant starch (RS) offer potential health benefits. Previous studies using chemical mutagenesis or RNA interference have demonstrated that starch branching enzyme (SBE) plays a major role in determining the fine structure and physical properties of starch. However, it remains a challenge to control starch branching in commercial lines. Here, we use CRISPR/Cas9 technology to generate targeted mutagenesis in SBEI and SBEIIb in rice. The frequencies of obtained homozygous or bi-allelic mutant lines with indels in SBEI and SBEIIb in T0 generation were from 26.7 to 40%. Mutations in the homozygous T0 lines stably transmitted to the T1 generation and those in the bi-allelic lines segregated in a Mendelian fashion. Transgene-free plants carrying only the frame-shifted mutagenesis were recovered in T1 generation following segregation. Whereas no obvious differences were observed between the sbeI mutants and wild type, sbeII mutants showed higher proportion of long chains presented in debranched amylopectin, significantly increased AC and RS content to as higher as 25.0% and 9.8%, respectively, and thus altered fine structure and nutritional properties of starch. Taken together, our results demonstrated for the first time the feasibility to create high-amylose rice through CRISPR/Cas9-mediated editing of SBEIIb. [less ▲]

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See detailSwitching Costs in Two-sided Markets
Lam, Wing Man Wynne ULg

in Journal of Industrial Economics (2017), 65(1), 136-182

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See detailTrypanosomiasis challenge estimation using the diminazene aceturate (Berenil) index in Zebu in Gabon.
COSSIC, Brieuc; ADJAHOUTONON, B; GLOAGUEN, P et al

in Tropical Animal Health and Production (2017), 49(3), 619-624

A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an ... [more ▼]

A longitudinal study was conducted within a cattle ranch in Gabon to determine the diminazene aceturate (Berenil) index (DAI) in a group of Zebu, raised under low tsetse density; this measure providing an assessment of trypanosomiasis risk. The objective was to evaluate the trypanosomiasis pressure thus informing trypanosomiasis control methods and cattle management. Twenty female adult Zebu were monitored for 24 weeks during the dry season. Blood samples were collected on aweekly basis and subjected to parasitological and haematological analysis (n = 480), using the buffy-coat method and the packed cell volume value (PCV), respectively, infected animals were treated with a single intramuscular injection of diminazene aceturate (8 mg/kg). Twenty-nine single infectious events were recorded and a DAI of 1.45 was calculated. Two trypanosome species were identified: Trypanosoma congolense (96.2%) and Trypanosoma vivax (3.8%). The mean PCV value of the infected animals was lower (26.6) compared to non-infected animals (32.0). This study shows that DAI may be a useful tool to assess trypanosomiasis. However, this is a time-consumingmethod that may be improved by using randomly selected sentinel animals to adapt the chemoprophylactic schemes, hence decreasing the costs and the drug resistance risk. [less ▲]

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See detailEntandrophragma cylindricum (Sprague) Sprague (Meliaceae), une espèce ligneuse concurrentielle en Afrique centrale (synthèse bibliographique)
Tabi Eckebil, Paule ULg; Verheggen, François ULg; Doucet, Jean-Louis ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21(1), 80-97

Introduction. De nos jours, la gestion des ressources forestières ne se focalise plus sur l’exploitation exclusive du bois d’oeuvre, mais prend également en considération les produits forestiers non ... [more ▼]

Introduction. De nos jours, la gestion des ressources forestières ne se focalise plus sur l’exploitation exclusive du bois d’oeuvre, mais prend également en considération les produits forestiers non ligneux. Entandrophragma cylindricum (Sprague) Sprague, de son nom commercial « sapelli/sapele », de la famille des Meliaceae, illustre parfaitement cette situation. Le présent article fait un état de l’art des connaissances concernant E. cylindricum et présente quelques informations sur la chenille qui lui est inféodée. Littérature. Le sapelli est une des espèces ligneuses les plus exploitées d’Afrique centrale pour son bois d’oeuvre. Il est répandu dans la forêt dense humide semi-caducifoliée du domaine guinéo-congolais. C’est une espèce semi-héliophile, son mode de dispersion est anémochore et sa phénologie est régulière. Selon la sylviculture appliquée, sa croissance en diamètre peut atteindre jusque 0,82 cm par an. Cette essence est également l’hôte d’une espèce de chenille comestible riche en protéines, I. oyemensis Rougeot. Fortement appréciée par les populations locales, cette chenille fait également l’objet d’un commerce régional et international. Enfin, l’écorce du sapelli est reconnue pour son intérêt ethnobotanique, particulièrement en médecine traditionnelle. Conclusions. Les informations tirées de la littérature ont permis de mettre en évidence certaines lacunes relatives à l’écologie et au mode de reproduction de cette espèce et, ceci, en dépit de son importance pour le commerce du bois. De plus, les inconnues quant à la productivité et la saisonnalité des chenilles d’Imbrasia oyemensis sur cet arbre nécessitent de développer des recherches complémentaires pour garantir la durabilité de l’exploitation simultanée de la ressource ligneuse et non ligneuse et pour proposer des modes de gestion concertés entre exploitants industriels et populations locales. [less ▲]

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See detailRendre compte de la société d’aujourd’hui
Quoilin, Cécile; Postula, Jean-Louis ULg

in Cahiers de muséologie - Dans la marge (2017)

Founded a century ago as a classical museum of regional ethnography, the Museum of Walloon Life is now facing the challenge of an essential update and the redefinition of its museum project. For about ten ... [more ▼]

Founded a century ago as a classical museum of regional ethnography, the Museum of Walloon Life is now facing the challenge of an essential update and the redefinition of its museum project. For about ten years, the choice of the approach known as "society museum" on the occasion of the total renovation of the building, led to an in-depth review of the acquisition and exhibition policies but also of the nature of field research and relationships with its different audiences. This article shows the practical consequences of the implementation of this new model, which now places the man rather than the collections at the center of discourse, on all museum functions. One of its fundamental objectives is to allow the development within the Museum of the sometimes complex issues of contemporary society. [less ▲]

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See detailThe origin of CIMP or how to increase international contacts between Paleozoic palynologists during the second part of last century.
Streel, Maurice ULg

in Commission internationale de la microflore du Paléozoïque CIMP Newsletter (2017), 86

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See detailExperimental Correction of Radiation Patterns Between Electromagnetic Environments
Spirlet, Maxime ULg; Geuzaine, Christophe ULg; Beauvois, Véronique ULg

in IEEE Transactions on Antennas & Propagation (2017), 65(03),

This manuscript presents an experimental method to estimate a radiation pattern obtained in a particular echoic environment (for example from in-situ measurements) as if measurements were performed in a ... [more ▼]

This manuscript presents an experimental method to estimate a radiation pattern obtained in a particular echoic environment (for example from in-situ measurements) as if measurements were performed in a given anechoic chamber. The correction is achieved using some reference measurements collected both in echoic and anechoic environments. An angular transfer function is estimated from these two sets of measurements and deconvolved from the measured radiation pattern to be corrected. [less ▲]

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See detailL'acte d'imagination: Approches phénoménologiques
Hagelstein, Maud ULg; Hervy, Alievtina ULg; Leclercq, Bruno ULg

in Bulletin d'Analyse Phénoménologique (2017), 13 (2017)(2),

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte ... [more ▼]

Du 25 au 29 avril 2016, le centre « Phénoménologies » de l’Université de Liège a tenu la dixième édition de son séminaire international de recherche en phénoménologie. Autour du thème général L’Acte d’imagination : approches phénoménologiques, vingt-huit chercheurs issus de vingt-deux universités différentes se sont rencontrés pendant une semaine entière pour discuter dans le détail plusieurs aspects de la problématique. Le volume actuel reprend la plupart des communications qui avaient été présentées durant cette semaine, communications ici retravaillées pour intégrer les propositions qu’avaient suscitées leur présentation originale et plus généralement l’ensemble des débats très riches qu’avait permis la constitution ponctuelle d’une vraie communauté philosophique. Kant avait notoirement fait de la faculté d’imagination un intermédiaire (un peu indécis) entre la réceptivité de l’expérience sensible et la spontanéité de l’entendement. En s’installant plus nettement sur le terrain de la psychologie descriptive et en abandonnant le vocabulaire des « facultés » pour lui préférer celui des actes mentaux ou des fonctions psychiques, les brentaniens s’étaient donné les moyens d’analyser plus finement les composantes de l’acte d’imagination (mode de visée, contenu réel, contenu intentionnel...), les rapports de fondation qu’il entretient avec d’autres types d’actes, et par là le rôle qu’il peut jouer dans les fonctions cognitives ou évaluatives de l’esprit. C’est de cet acte d’imagination, envisagé par la phénoménologie en tant que psychologie descriptive, qu’il sera ici question. [less ▲]

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See detailStructure impact of two galactomannan fractions on their viscosity properties in dilute solution, unperturbed state and gel state
Gillet, Sébastien; Aguedo, Mario ULg; Petrut, Raoul et al

in International Journal of Biological Macromolecules (2017), 96

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See detailConstraining the efficiency of angular momentum transport with asteroseismology of red giants: the effect of stellar mass
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomy and Astrophysics (2017), 599

Context: Constraints on the internal rotation of red giants are now available thanks to asteroseismic observations. Preliminary comparisons with rotating stellar models indicate that an undetermined ... [more ▼]

Context: Constraints on the internal rotation of red giants are now available thanks to asteroseismic observations. Preliminary comparisons with rotating stellar models indicate that an undetermined additional process for the internal transport of angular momentum is required in addition to purely hydrodynamic processes. Aims: We investigate how asteroseismic measurements of red giants can help us characterize the additional transport mechanism. Methods: We first determine the efficiency of the missing transport mechanism for the low-mass red giant KIC 7341231 by computing rotating models that include an additional viscosity corresponding to this process. We then discuss the change in the efficiency of this transport of angular momentum with the mass, metallicity and evolutionary stage. Results: In the case of the low-mass red giant KIC 7341231, we find that the viscosity corresponding to the additional mechanism is constrained to the range 1 x 10^3 - 1.3 x 10^4 cm^2/s. This constraint on the efficiency of the unknown additional transport mechanism during the post-main sequence is obtained independently of any specific assumption about the modelling of rotational effects during the pre-main sequence and the main sequence (in particular, the braking of the surface by magnetized winds and the efficiency of the internal transport of angular momentum before the post-main-sequence phase). When we assume that the additional transport mechanism is at work during the whole evolution of the star together with a solar-calibrated braking of the surface by magnetized winds, the range of nu_add is reduced to 1 - 4 x 10^3 cm^2/s. In addition to being sensitive to the evolutionary stage of the star, we show that the efficiency of the unknown process for internal transport of angular momentum increases with the stellar mass. [less ▲]

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See detailMens sana in corpore sano
RADERMECKER, Régis ULg

in Revue de l'Association Belge du Diabète (2017), 60(2),

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See detailSeasonal plasticity of auditory saccular sensitivity in “sneaker” type II male plainfin midshipman fish, Porichthys notatus
Bhandiwad, Ashwin A.; Whitchurch, Elizabeth A.; Colleye, Orphal ULg et al

in Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural and Behavioral Physiology (2017), 203(3), 211-222

Adult female and nesting (type I) male midshipman fish (Porichthys notatus) exhibit an adaptive form of auditory plasticity for the enhanced detection of social acoustic signals. Whether this adaptive ... [more ▼]

Adult female and nesting (type I) male midshipman fish (Porichthys notatus) exhibit an adaptive form of auditory plasticity for the enhanced detection of social acoustic signals. Whether this adaptive plasticity also occurs in “sneaker” type II males is unknown. Here, we characterize auditory-evoked potentials recorded from hair cells in the saccule of reproductive and non-reproductive “sneaker” type II male midshipman to determine whether this sexual phenotype exhibits seasonal, reproductive state-dependent changes in auditory sensitivity and frequency response to behaviorally relevant auditory stimuli. Saccular potentials were recorded from the middle and caudal region of the saccule while sound was presented via an underwater speaker. Our results indicate saccular hair cells from reproductive type II males had thresholds based on measures of sound pressure and acceleration (re. 1 μPa and 1 ms−2, respectively) that were ~8–21 dB lower than non-reproductive type II males across a broad range of frequencies, which include the dominant higher frequencies in type I male vocalizations. This increase in type II auditory sensitivity may potentially facilitate eavesdropping by sneaker males and their assessment of vocal type I males for the selection of cuckoldry sites during the breeding season. [less ▲]

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See detailScrutin proportionnel scrutin majoritaire
Verjans, Pierre ULg; Matagne, Geoffroy ULg; Counet, Maxime ULg

in Politique revue belge d'analyse et de débats (2017), 98-99

Le scrutin proportionnel utilisé en Belgique produit des gouvernements de coalition où la recherche du compromis et du consensus est obligatoire tandis que le scrutin majoritaire utilisé en France produit ... [more ▼]

Le scrutin proportionnel utilisé en Belgique produit des gouvernements de coalition où la recherche du compromis et du consensus est obligatoire tandis que le scrutin majoritaire utilisé en France produit des gouvernements monopartisans qui tentent de transformer leur société par des mesures non négociées. Chaque mode de sélection a ses avantages. [less ▲]

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See detailHow the reference values for serum parathyroid hormone concentration are (or should be) established?
Souberbielle, J.-C.; Brazier, F.; Piketty, M.-L. et al

in Journal of Endocrinological Investigation (2017), 40(3), 241-256

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria ... [more ▼]

Well-validated reference values are necessary for a correct interpretation of a serum PTH concentration. Establishing PTH reference values needs recruiting a large reference population. Exclusion criteria for this population can be defined as any situation possibly inducing an increase or a decrease in PTH concentration. As recommended in the recent guidelines on the diagnosis and management of asymptomatic primary hyperparathyroidism, PTH reference values should be established in vitamin D-replete subjects with a normal renal function with possible stratification according to various factors such as age, gender, menopausal status, body mass index, and race. A consensus about analytical/pre-analytical aspects of PTH measurement is also needed with special emphasis on the nature of the sample (plasma or serum), the time and the fasting/non-fasting status of the blood sample. Our opinion is that blood sample for PTH measurement should be obtained in the morning after an overnight fast. Furthermore, despite longer stability of the PTH molecule in EDTA plasma, we prefer serum as it allows to measure calcium, a prerequisite for a correct interpretation of a PTH concentration, on the same sample. Once a consensus is reached, we believe an important international multicentre work should be performed to recruit a very extensive reference population of apparently healthy vitamin D-replete subjects with a normal renal function in order to establish the PTH normative data. Due to the huge inter-method variability in PTH measurement, a sufficient quantity of blood sample should be obtained to allow measurement with as many PTH kits as possible. [less ▲]

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See detailLocal Identification of Voltage Instability from Load Tap Changer Response
Weckesser, Johannes ULg; Papangelis, Lampros ULg; Vournas, Costas et al

in Sustainable Energy, Grids and Networks (2017)

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations ... [more ▼]

This paper presents a local long-term voltage instability monitoring method, which is suitable for on-line applications. The proposed extended-time Local Identification of Voltage Emergency Situations (eLIVES) method is a significantly modified version of the previously presented LIVES method. The new method is not bound to assessing system response over a predefined LTC tapping period. This allows handling LTCs with variable delays, as well as events taking place during the tapping sequence impacting the distribution voltages. For that purpose, eLIVES applies recursive least square fitting to acquired distribution voltage measurements and a new set of rules to detect a voltage emergency situation. The effectiveness of the eLIVES method is presented on the IEEE Nordic test system for voltage stability and security assessment. [less ▲]

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See detailEtude de la composition chimique et de l’activité antioxydante des différents extraits de la Lavande dentée (Lavandula dentata)
Bettaieb Rebey, I.; Bourgou, S.; Saidani Tounsi, M. et al

in Journal of New Sciences Agri & Biotech (2017), 39(2), 2096-2105

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0 ... [more ▼]

In this study, Lavandula dentata organs (roots, stems and leaves) were investigated for their essential oils, total phenolics, flavonoids contents and antioxidant activities. Essential oil yields were 0.22% in roots, 0.68 % in stems and 0.89 % in flowers. Major components of the oils were β-ocimene, limonene and 1,8 cineol in roots, stems and leaves and flowers, respectively. In all organs, total phenolics content ranged from 42.57 to 16.17 mg gallic acid equivalents per gram of dry weight (mg GAE/g DW).The antioxidant activities of Lavandula dentata extracts obtained from the three organs were assessed using two tests (DPPH and reducing power). The root extract was strongly effective as DPPH radical scavenger and reducing agent. Thus, the identification of individual target polyphenolic compounds of roots was performed by RP-HPLC. The major phenolic compound detected in roots was rosmarinic acid. This activity was high enough for the plant to be a new and natural source of strongly antioxidant substances for use as natural additives in food and pharmaceutical industry. [less ▲]

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See detailThe Future Prevalence of Sarcopenia in Europe: A Claim for Public Health Action.
Ethgen, Olivier ULg; Beaudart, Charlotte ULg; Buckinx, Fanny ULg et al

in Calcified Tissue International (2017), 100(3), 229-234

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected ... [more ▼]

Sarcopenia is a major public health issue. To convince health policy makers of the emergency to invest in the sarcopenia field, it is of critical importance to produce reliable figures of the expected burden of sarcopenia in the coming years. Age- and gender-specific population projections were retrieved until 2045 from the Eurostat online database (28 European countries). Age- and gender-specific prevalences of sarcopenia were interpolated from a study that compared prevalence estimates according to the different diagnostic cutoffs of the EWGSOP proposed definition. The reported prevalence estimates were interpolated between 65 and 100 years. Interpolated age- and gender-specific estimates of sarcopenia prevalence were then applied to population projections until 2045. Using the definition providing the lowest prevalence estimates, the number of individuals with sarcopenia would rise in Europe from 10,869,527 in 2016 to 18,735,173 in 2045 (a 72.4% increase). This corresponds to an overall prevalence of sarcopenia in the elderly rising from 11.1% in 2016 to 12.9% in 2045. With the definition providing the highest prevalence estimates, the number of individuals with sarcopenia would rise from 19,740,527 in 2016 to 32,338,990 in 2045 (a 63.8% increase), corresponding to overall prevalence rates in the elderly of 20.2% and 22.3% for 2016 and 2045, respectively. We showed that the number of sarcopenic patients will dramatically increase in the next 30 years, making consequences of muscle wasting a major public health issue. [less ▲]

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See detailLA THÉRAPIE MANUELLE ORTHOPÉDIQUE : définition, caractéristiques et mise au point sur la situation en Belgique
Demoulin, Christophe ULg; Depas, Yannick ULg; Vanderthommen, Marc ULg et al

in Revue Médicale de Liège (2017), 72(3), 126-131

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian ... [more ▼]

Orthopaedic manual therapy : definition, characteristics and update on the situation in Belgium Summary : Although orthopaedic manual therapy (OMT) has existed for decades, and although a recent Belgian Royal Decree, published in 2014, recognized it as a particular professional qualification in physiotherapy for the treatment of neuromusculoskeletal dysfunctions, OMT remains little known by patients, but also by healthcare professionals. Yet, this professional qualification, based on clinical reasoning, using highly specific treatments, guided by the best available scientific and clinical evidence and the specific biopsychosocial characteristics of each patient, is the subject of a growing number of scientific studies pointing out its effectiveness. This article summarizes the knowledge related to OMT (definition, history, characteristics, techniques, indications, access and reimbursement) and describes its situation in Belgium. [less ▲]

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See detailSpin waves on chains of YIG particles: dispersion relations, Faraday rotation, and power transmission
Pike, Nicholas ULg; Stroud, David

in European Physical Journal B -- Condensed Matter (2017), 90

We calculate the dispersion relations for spin waves on a periodic chain of spherical or cylindrical Yttrium Iron Garnet (YIG) particles. We use the quasistatic approximation, appropriate when kd <<1 ... [more ▼]

We calculate the dispersion relations for spin waves on a periodic chain of spherical or cylindrical Yttrium Iron Garnet (YIG) particles. We use the quasistatic approximation, appropriate when kd <<1, where k is the wave number and d the interparticle spacing. In this regime, because of the magnetic dipole-dipole interaction between the localized magnetic excitations on neighboring particles, dispersive spin waves can propagate along the chain. The waves are analogous to plasmonic waves generated by electric dipole-dipole interactions between plasmons on neighboring metallic particles. The spin waves can be longitudinal (L), transverse (T ), or elliptically polarized. We find that a linearly polarized spin wave undergoes a Faraday rotation as it propagates along the chain. The amount of Faraday rotation can be tuned by varying the off-diagonal component of the permeability tensor. We also discuss the possibility of wireless power transmission along the chain using these coupled spin waves. [less ▲]

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See detailEnglish translation and validation of the SarQoL®, a quality of life questionnaire specific for sarcopenia
Beaudart, Charlotte ULg; Edwards, Mark; Moss, Charlotte et al

in Age & Ageing (2017), 46(2), 271-7

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this ... [more ▼]

Background: the first quality of life questionnaire specific to sarcopenia, the SarQoL®, has recently been developed and validated in French. To extend the availability and utilisation of this questionnaire, its translation and validation in other languages is necessary. Objective: the purpose of this study was therefore to translate the SarQoL® into English and validate the psychometric properties of this new version. Design: cross-sectional. Setting: Hertfordshire, UK. Subjects: in total, 404 participants of the Hertfordshire Cohort Study, UK. Methods: the translation part was articulated in five stages: (i) two initial translations from French to English; (ii) synthesis of the two translations; (iii) backward translations; (iv) expert committee to compare the backward translations with the original questionnaire and (v) pre-test. To validate the English SarQoL®, we assessed its validity (discriminative power, construct validity), reliability (internal consistency, test–retest reliability) and floor/ceiling effects. Results: the SarQoL® questionnaire was translated without any major difficulties. Results indicated a good discriminative power (lower score of quality of life for sarcopenic subjects, P = 0.01), high internal consistency (Cronbach’s alpha of 0.88), consistent construct validity (high correlations found with domains related to mobility, usual activities, vitality, physical function and low correlations with domains related to anxiety, self-care, mental health and social problems) and excellent test–retest reliability (intraclass coefficient correlation of 0.95, 95%CI 0.92–0.97). Moreover, no floor/ceiling has been found. Conclusions: a valid SarQoL® English questionnaire is now available and can be used with confidence to better assess the disease burden associated with sarcopenia. It could also be used as a treatment outcome indicator in research. [less ▲]

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See detailUne courbe rentrante dans le contentieux administratif ? Quand le législateur veut éviter ou neutraliser l’annulation par le Conseil d’Etat
Pâques, Michel ULg

in Revue de la Faculté de Droit de l'Université de Liège (2017), 2017-1

DOCTRINE La Faculté de droit de l’Université de Liège. Notes historiques succinctes, par Patrick Wautelet Gardez votre carte d’identité en poche, par Frédéric Bouhon Les illégalités que l’on ne voit pas ... [more ▼]

DOCTRINE La Faculté de droit de l’Université de Liège. Notes historiques succinctes, par Patrick Wautelet Gardez votre carte d’identité en poche, par Frédéric Bouhon Les illégalités que l’on ne voit pas : Enseignements tirés du droit de l’arbitrage, par Olivier Caprasse Les barèmes de rémunération : la périlleuse transition de l’âge à l’expérience pour éliminer la discrimination, par Jacques Clesse De l’information (légale) à l’action (illégale) : Tests génétiques et technologies de pouvoir, par Catherine Fallon « La madone et la putain » : Quand les stéréotypes de genres influencent la perception de la légalité des violences sexuelles et le traitement de la réaction sociale à l’égard des femmes, par Serge Garcet Les circulaires administratives fiscales illégales, par Luc Herve Le licenciement en cas de congé pour assistance à un proche gravement malade et de congé pour soins palliatifs : une inconstitutionnalité créée par la Cour constitutionnelle ? Par Fabienne Kéfer Des tribulations des actions possessoires : entre illégalité et inconstitutionnalité, par Pascale Lecocq Lorsque l’Union européenne réaffirme sa norme : la réponse par l’absurde aux craintes de ses citoyens ? Par Quentin Michel L’intervention de l’assureur dans le procès pénal : la défense de ton assuré tu assumeras ? Par Olivier Michiels Défaut de motivation formelle et droit administratif de la sécurité sociale : des illégalités à redécouvrir ? Par Hugo Mormont Une courbe rentrante dans le contentieux administratif ? Quand le législateur veut éviter ou neutraliser l’annulation par le Conseil d’État, par Michel Pâques Au nom de l’ordre pénitentiaire. L’impératif de sécurité, générateur d’illégalités ? Par Vincent Seron Quis custodiet ipsos custodies ? Libres propos sur les violations de la légalité couvertes, admises, entérinées ou commises par les cours suprêmes, par Nicolas Thirion The Dodd-Frank Bounty Program: Disclosing the Unknown (and Getting Handsomely Paid For It), par François vander Mensbrugghe La « discrimination à rebours » au sein du marché intérieur : une illégalité qu’il ne faut pas voir au niveau européen ? Par Pieter van Cleynenbreugel La transaction pénale : des illégalités visibilisées aux ill(n)égalités moins visibles, par Charlotte vanneste Illégalité et jugements étrangers, par Patrick Wautelet VIE DU DROIT Autour et alentours des Leçons inaugurales de la Faculté de droit, de science politique et de criminologie de l’Université de Liège, par Patrick Wautelet Du zéro-vivant au zéro-mort, par André Dumoulin Le notaire refuse, par Gabriel Rasson Décider ensemble ou vivre ensemble ? Quelques pas de danse sur un air de tango, par Frédéric Bouhon D’une victime à l’autre : Posture ou (im)posture victimaire ? Par Serge Garcet Pouvoir politique et audace des juges, par Geoffrey Grandjean Hommage à Didier Matray, par Olivier Caprasse, Didier Matray et Pascale Lecocq [less ▲]

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