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See detailOutcomes of UCB transplantation are comparable in FLT3+ AML: Results of CIBMTR, eurocord and EBMT collaborative analysis.
Ustun, C.; Giannotti, F.; Zhang, M.-J. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2017)

Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML ... [more ▼]

Allogeneic hematopoietic cell transplantation (HCT) from siblings or unrelated donors (URD) during complete remission (CR) may improve leukemia-free survival (LFS) in FLT3+ acute myeloid leukemia (AML) that has poor prognosis due to high relapse rates. Umbilical cord blood (UCB) HCT outcomes are largely unknown in this population. We found that compared with sibling HCT, relapse risks were similar after UCB (n=126), (HR 0.86, P=0.54) and URD (n=91) (HR 0.81, P=0.43). UCB HCT was associated with statistically higher non-relapse mortality compared with sibling HCT (HR 2.32, P=0.02), but not vs URD (HR 1.72, P=0.07). All three cohorts had statistically not significant 3-year LFS: 39% (95% CI 30-47) after UCB, 43% (95% CI 30-54) after sibling, and 50% (95% CI 40-60) after URD. Chronic GVHD rates were significantly lower after UCB compared with either sibling (HR 0.59, P=0.03) or URD (HR 0.49, P=0.001). Adverse factors for LFS included high leukocyte count at diagnosis and HCT during CR2. UCB is a suitable option for adults with FLT3+AML in the absence of an HLA-matched sibling and its immediate availability may be particularly important for FLT3+ AML where early relapse is common thus allowing HCT in CR1 when outcomes are best.Leukemia accepted article preview online, 25 January 2017. doi:10.1038/leu.2017.42. [less ▲]

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See detailRectal cancer treatment in a teaching hospital
Verdin, Vanessa; Weerts, Joseph; Francart, David et al

in Acta Chirurgica Belgica (2017), 117

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards ... [more ▼]

Background: Rectal adenocarcinomas surgery morbidity and mortality might be impaired by neoadjuvant therapy. We performed this retropsective study to be compared with the PROCARE study running afterwards. Methods: We performed a retrospective study of 95 patients operated on for rectal denocarcinoma in a single institution during the period 2007-2009. We used logistic regression to estimate the relationship between possible predictive parameters of AL. Results: The laparoscopic approach is favored in 63.1% of the cases with a conversion rate of 11.6%, mainly in man (6 out of 7). For low rectal cancer though, laparotomy was the first choice (92.3%). From a carcinological point of view, laparoscopy allowed a complete tumor resection according to the PME (n=27) and TME (n=26) standards. Multivariate analysis revealed that women, lower BMI, lower rectum tumor, laparoscopic surgery, neoadjuvant treatment and anal suture were associated with higher risk of AL. The mean hospital stay was 15.4 days (3 – 46 days). In-hospital mortality was 3.1%. Adjuvant chemotherapy was completed in 42.1% of the patients. Despite these treatments, we registered a recurrence rate of 26.6%. Of these, 72% were distally localized and 12% exclusively locally. Among the patients operated on by laparoscopy, there was one local recurrence and one local with distant metastases (3.7%). The one- and three-years survival rates were 91.5% and 80.4% respectively. Conclusions: Our study showed a higher rate of AL than expected (18%). In our series recorded in PROCARE-Home, our leak rate has dropped to 10%. It may be indicating a positive effect of PROCARE. [less ▲]

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See detailComparison between sedation and general anesthesia for high resolution computed tomographic characterization of canine idiopathic pulmonary fibrosis in west highland white terriers
Roels, Elodie ULg; Couvreur, Thierry; Farnir, Frédéric ULg et al

in Veterinary Radiology & Ultrasound (2017)

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive interstitial lung disease mainly affecting West Highland white terriers (WHWTs). Thoracic high-resolution computed tomographic (T-HRCT ... [more ▼]

Canine idiopathic pulmonary fibrosis (CIPF) is a progressive interstitial lung disease mainly affecting West Highland white terriers (WHWTs). Thoracic high-resolution computed tomographic (T-HRCT) findings for CIPF acquired under general anesthesia have been described previously. However, the use of general anesthesia may be contraindicated for some affected dogs. Sedation may allow improved speed and safety, but it is unknown whether sedation would yield similar results in identification and grading of CIPF lesions. The aim of this prospective, observational, method-comparison, case-control study was to compare findings from T-HRCT images acquired under sedation versus general anesthesia for WHWTs affected with CIPF (n=11) and age-matched controls (n=9), using the glossary of terms of the Fleischner Society and a scoring system. Ground-glass opacity (GGO) was identified in all affected WHWTs for both sedation and general anesthesia acquisitions, although the GGO extent varied significantly between the two acquisitions (P<0.001). Ground-glass opacity was the sole lesion observed in control dogs (n=6), but was less extensive compared with affected WHWTs. Identification and grading of a mosaic attenuation pattern differed significantly between acquisitions (P<0.001). Identification of lesions such as consolidations, nodules, parenchymal and subpleural bands, bronchial wall thickening, and bronchiectasis did not differ between acquisitions. The present study demonstrated that T-HRCT obtained under sedation may provide different information than T-HRCT obtained under general anesthesia for identification and grading of some CIPF lesions, but not all of them. These differences should be taken into consideration when general anesthesia is contraindicated and sedation is necessary for evaluating WHWTs with CIPF. [less ▲]

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See detailDepth-speci c Fluctuations of gene expression and protein abundance modulate the photophysiology in the seagrass Posidonia oceanica
Procaccini, Gabriele; Ruocco, Miriam; Marin-Guirao, Lazaro et al

in Scientific Reports (2017), 7(42890), 1-14

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light ... [more ▼]

We present the results of a multiple organizational level analysis conceived to identify acclimative/ adaptive strategies exhibited by the seagrass Posidonia oceanica to the daily uctuations in the light environment, at contrasting depths. We assessed changes in photophysiological parameters, leaf respiration, pigments, and protein and mRNA expression levels. The results show that the diel oscillations of P. oceanica photophysiological and respiratory responses were related to transcripts and proteins expression of the genes involved in those processes and that there was a response asynchrony between shallow and deep plants probably caused by the strong di erences in the light environment. The photochemical pathway of energy use was more e ective in shallow plants due to higher light availability, but these plants needed more investment in photoprotection and photorepair, requiring higher translation and protein synthesis than deep plants. The genetic di erentiation between deep and shallow stands suggests the existence of locally adapted genotypes to contrasting light environments. The depth-speci c diel rhythms of photosynthetic and respiratory processes, from molecular to physiological levels, must be considered in the management and conservation of these key coastal ecosystems. [less ▲]

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See detailDéficits de la conscience autonoétique et de la mémoire autobiographique: résultats d'une intervention cognitive dans la schizophrénie.
Boulanger, Marie ULg; Neumann, Aurore; Blairy, Sylvie ULg

in Pratiques Psychologiques (2017)

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants ... [more ▼]

The study evaluates the effects of a cognitive intervention called Self-Awareness Therapy (SAT) on abilities of mental time travel in deficit in schizophrenia. Among whole schizophrenia participants, seven participated in SAT, four took part in the Integrative Program Therapy (IPT) and six followed a treatment as usual. Before and after interventions, participants were asked to complete TEMPau for autonoetic awareness and autobiographical memory such as TeMA, for autobiographical memory and projection into future events. Intragroups and individual statistical analyses were conducted. The participants of SAT intervention reported more specific past TEMPau and future specific events on TeMA after therapy. Results support that, in schizophrenia, the retrieving of past specific memories and projection into future specific events could be improved under certain conditions only. [less ▲]

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See detailMultiple myeloma bone disease: from mechanisms to next generation therapy
Heusschen, Roy ULg; Muller, Joséphine ULg; WITHOFS, Nadia ULg et al

in Belgian Journal of Hematology (2017)

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See detailStructure impact of two galactomannan fractions on their viscosityproperties in dilute solution, unperturbed state and gel state
Gillet, Sébastien; Aguedo, Mario ULg; Petrut, Raul Flaviu ULg et al

in International Journal of Biological Macromolecules (2017), 96

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See detailSampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study
Thiry, Justine ULg; Evrard, Brigitte ULg; Nys, Gwenaël ULg et al

in Journal of Chromatography. A (2017), 1479

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to ... [more ▼]

Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to collect small quantities (10 or 20 µL) of whole blood, thereby limiting the amount of animals needed. In this study, a quantitative method was developed and subsequently validated for the poorly soluble drug itraconazole (ITZ) using VAMS and ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS). A proof of concept study showed that the optimized method is applicable to test the bioavailability of drug formulations containing ITZ. Using VAMS, smaller blood volumes can be taken per sampling point (10-20 µL instead of the conventional 0.2-0.5 mL) avoiding the sacrifice of animals. Moreover, the same rats can be used to compare different drug formulations which strengthens the validity of the results. In long-term bioavailability studies, it is necessary to guarantee the stability of the tested drugs supported on VAMS devices. In this study, we show that ITZ was only stable for 24 hours after collection with VAMS, but for at least two weeks by the storage of extracted samples at -80°C. [less ▲]

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See detailFifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016
Simón, F.; Kartashev, V.; González-Miguel, J. et al

in Parasites & Vectors (2017), 10(1), 5

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See detailMolecular dynamics study of micelle proeprties according to their size
Lebecque, Simon ULg; Crowet, Jean-Marc ULg; Nasir, Mehmet Nail ULg et al

in Journal of Molecular Graphics and Modelling (2017)

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have ... [more ▼]

Surfactants are molecules able to spontaneously self-assemble to form aggregates with well-defined properties, such as spherical micelles, planar bilayers, cylindrical micelles or vesicles. Micelles have notably several applications in many domains, such as drug delivery or membrane protein solubilization. In this context, the study of micelle formation in relation with the structural and physico-chemical properties of surfactants is of great interest to better control their use in the different application fields. In this work, we use the MD approach developed by Yoshii et al. and extend it to surfactants with different structures. We aim to systematically investigate different micellar properties as a function of the aggregates size by a molecular dynamics approach, to get an insight into the micellar organization and to collect some relevant descriptors about micelle formation. For this, we perform short MD simulations of preformed micelles of various sizes and analyze three parameters for each micelle size, namely the eccentricity of the micelles, the hydrophobic/hydrophilic surface ratio and the hydrophobic tails hydration. If these parameters are known descriptors of micelles, they were not yet studied in this way by MD. We show that eccentricity, used as “validator” parameter, exhibits minimal values when the aggregate size is close to the experimental aggregation number for surfactants that are known to form spherical micelles. This hence indicates that our methodology gives consistent results. The evolution of the two descriptors follows another scheme, with a sharp increase and decrease, respectively, followed by a leveling-off. The aggregate sizes at which this stabilization starts to occur are close to the respective aggregation number of each surfactant. In our approach, we validate the use of these descriptors to follow micelle formation by MD, from “simple” surfactants to more complex structures, like lipopeptides. Our calculations also suggest that some peculiar behavior, like that of TPC, can be highlighted by our approach. In the context of peptidic surfactants, our methodology could further help to improve computer simulations combined to molecular thermodynamic models to predict micellar properties of those more complex amphiphilic molecules. [less ▲]

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See detailConcise Reviews: Regeneration in Mammalian Cochlea Hair Cells: Help from Supporting Cells Transdifferentiation.
Franco, Benedicte; Malgrange, Brigitte ULg

in Stem cells (Dayton, Ohio) (2017)

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice ... [more ▼]

It is commonly assumed that mammalian cochlear cells do not regenerate. Therefore, if hair cells are lost following an injury, no recovery could occur. However, during the first postnatal week, mice harbor some progenitor cells that retain the ability to give rise to new hair cells. These progenitor cells are in fact supporting cells. Upon hair cells loss, those cells are able to generate new hair cells both by direct transdifferentiation or following cell cycle re-entry and differentiation. However, this property of supporting cells is progressively lost after birth. Here, we review the molecular mechanisms that are involved in mammalian hair cell development and regeneration. Manipulating pathways used during development constitute good candidates for inducing hair cell regeneration after injury. Despite these promising studies, there is still no evidence for a recovery following hair cells loss in adult mammals. Stem Cells 2017. [less ▲]

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See detailFactors associated with self-perceived burden to the primary caregiver in older patients with hematologic malignancies: an exploratory study
Libert, Y; Borghgraef, C; BEGUIN, Yves ULg et al

in Psycho-oncology (2017), 10

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of ... [more ▼]

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of selfperceived burden to the primary caregiver (SPB-PC) and associated factors in an older patient population with hematologic malignancies at the time of chemotherapy initiation. Methods: In total, 166 consecutive patients with hematologic malignancies aged ≥65 years were recruited at the time of chemotherapy initiation. Patients’ SPB-PC was assessed using a 100-mm visual analogue scale (VAS). Characteristics potentially associated with SPB-PC, including sociodemographic and medical characteristics, physical functioning status (Karnofsky performance score, activities of daily living (ADL)/instrumental ADL), symptoms (fatigue, pain, nausea, quality of life), psychological distress (Hospital Anxiety and Depression Scale (HADS)), perceived cognitive function (Functional Assessment of Cancer Therapy Cognitive (FACT-Cog) Scale), and patients’/primary caregivers’ personal relationship characteristics (family tie, support), were assessed. Results: Thirty-five percent of patients reported moderate to severe SPB-PC (VAS ≥ 50 mm). Patients’ SPB-PC was associated with lower Karnofsky performance (β = 0.135, p = 0.058) and ADL (β = 0.148, p = 0.037) scores, and higher HADS (β = 0.283, p<0.001) and FACT-Cog perceived cognitive impairments subscale (β = 0.211, p = 0.004) scores. The proportion of explained variance was 23.5%. Conclusions: Health care professionals should be aware that about one third of older cancer patients experience moderate to severe SPB-PC at the time of chemotherapy initiation. They should adapt their support of patients who report such a feeling. [less ▲]

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See detailMethylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.
Chiavarina, Barbara ULg; Nokin, Marie-Julie ULg; Bellier, Justine ULg et al

in International Journal of Molecular Sciences (2017), 18(1),

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and ... [more ▼]

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. [less ▲]

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See detailThe link between self-perceptions of aging, cancer view and physical and mental health of older people with cancer: A cross-sectional study
Schroyen, Sarah ULg; Marquet, Manon ULg; Jerusalem, Guy ULg et al

in Journal of Geriatric Oncology (2017)

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has ... [more ▼]

Objectives Older people may suffer from stigmas linked to cancer and aging. Although some studies suggested that a negative view of cancer may increase the level of depression, such an association has never been studied in the elderly population. Similarly, even though it is established that a negative self-perception of aging has deleterious consequences on mental and physical health in normal aging, the influence in pathological contexts, such as oncology, has not been studied. The main aim of this study is thus to analyze the effect of these two stigmas on the health of elderly oncology patients. Materials and Methods 101 patients suffering from a cancer (breast, gynecological, lung or hematological) were seen as soon as possible after their diagnosis. Their self-perception of age, cancer view and health (physical and mental) was assessed. Results Multiple regressions showed that patients with a more negative self-perception of aging and/or more negative cancer view reported poorer global health. We also observed that negative self-perception of aging was associated with worse physical and mental health, whereas negative cancer views were only linked to worse mental health. No interaction was observed between these two stigmas, suggesting that their action is independent. Conclusion Older patients with cancer face double stigmatization, due to negative self-perception of aging and cancer, and these stigmas have impacts on global and mental health. Self-perception of aging is also linked to physical health. Longitudinal studies will be necessary to analyze the direction of the association between this double stigmatization and health. [less ▲]

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See detailEmployee perspectives on safety citizenship behaviors and safety violations
Chmiel, Nik; Laurent, Julie ULg; Hansez, Isabelle ULg

in Safety Science (2017), 93

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two ... [more ▼]

Two studies investigate whether employees viewing discretionary safety activities as part of their job role (termed safety citizenship role definitions, SCRDs) plays an important part in predicting two types of safety violation: routine violations conceptualized as related to an individual’s available cognitive energy or ‘effort’; and situational violations, which are those provoked by the organization (Reason, 1990). Study 1 showed SCRDs predicted situational violations only, and partially mediated the relationships between Perceived Management Commitment to Safety (PMCS) and work engagement with situational violations. These findings add to those by Hansez and Chmiel (2010), showing that routine and situational violations have predictors that differ. Study 1 findings also extend research reported by Turner et al. (2005), by showing that the effect of Job Control on SCRDs was mediated by both PMCS and work engagement. In study 2, participation in discretionary safety activities (safety participation) mediated the relationship between SCRDs and situational violations. Similar to study 1 The link between SCRDs and routine violations was non-significant and, strikingly, so was the link between safety participation and routine violations. These results support the view that processes involving SCRDs and safety participation are not cognitive-energetical in nature. In addition, study 2 findings extend previous work by Neal and Griffin (2006) by showing that SCRDs and safety knowledge partially mediated relationships between safety motivation and safety participation, whereas the direct effect of safety motivation on safety participation was non-significant. The results from both studies support the view that SCRDs are important in predicting situational violations. In study 2 SCRDs were shown to partially mediate the relationship between safety motivation and selfreported participation in discretionary safety activities (Safety Participation) which, in turn, related to situational violations. Interestingly there was no significant direct link between SCRDs and situational violations. These findings support the view that the effect of SCRDs on situational violations is fully mediated by participation in discretionary safety activities. [less ▲]

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See detailComparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure
Bertrand, Henri ULg; Springer, Svenja; Burnside, Wesley et al

in Laboratory Animals (2017)

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery ... [more ▼]

Volatile agents for anaesthesia are widely used for anaesthetizing laboratory primates, and isoflurane is one of the most frequently used agents. Sevoflurane has been shown to offer a more rapid recovery than iso- flurane in a number of species, but no comparisons have been made in non-human primates. This study compared the recovery characteristics of isoflurane and sevoflurane in rhesus macaques undergoing experi- mental neurosurgery. Twelve primates (7 males and 5 females) were randomly allocated to the treatment groups. They were sedated with ketamine (10 mg/kg) and anaesthesia was induced with propofol (usually 8 mg/kg intravenously [IV]). Anaesthesia was maintained with either sevoflurane (SEVO) (2.2 0.4%) or iso- flurane (ISO) (1.2 0.2%) and alfentanil (0.2–0.5 mg/kg/min IV) for 332–592 min. Animals were mechanically ventilated. Meloxicam (0.3mg/kg) and methylprednisolone infusion (5.4mg/kg/h) were also administered. Time to extubation after cessation of anaesthesia was significantly shorter with sevoflurane (ISO: 7.0 1.8 min; SEVO: 3.6 1.5; *P 1⁄4 0.005) as was the time to the animal sitting unaided (ISO: 15.7 8.2 min; SEVO: 7.1 1.7min; *P1⁄40.004). No significant difference in the quality of recovery following isoflurane or sevoflurane anaesthesia was found. In conclusion, isoflurane and sevoflurane are both suitable volatile agents for the maintenance of general anaesthesia in rhesus macaques undergoing experimental neurosur- gical procedures. The two volatile agents presented a similar emergence quality profile, however sevoflurane anaesthesia was associated with a faster recovery, offering the possibility of conducting earlier post-operative neurological assessment. [less ▲]

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See detailIntegration of Gene Expression and Methylation to unravel Biological Networks in Glioblastoma Patients
Bessonov, Kyrylo ULg; Gadaleta, Francesco; Van Steen, Kristel ULg

in Genetic Epidemiology (2017)

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information ... [more ▼]

The vast amount of heterogeneous omics data, encompassing a broad range of biomolecular information, requires novel methods of analysis, including those that integrate the available levels of information. In this work we describe Regression2Net, a computational approach that is able to integrate gene expression and genomic or methylome data in two steps. First, penalized regressions are used to build Expression-Expression (EEnet) and Expression-Genome or –Methylome (EMnet) networks. Second, network theory is used to highlight important communities of genes. When applying our approach Regression2Net to gene expression and methylation profiles for individuals with glioblastoma multiforme, we identified respectively 284 and 447 potentially interesting genes in relation to glioblastoma pathology. These genes showed at least one connection in the integrated networks ANDnet and XORnet derived from aforementioned EEnet and EMnet networks. Whereas the edges in ANDnet occur in both EEnet and EMnet, the edges in XORnet occur in EMnet but not in EEnet. In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response and several cancer types. Importantly, we observed significant over-representation of cancer related pathways including glioma, especially in the XORnet network, suggesting a non-ignorable role of methylation in glioblastoma multiforma. In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. [less ▲]

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See detailObservations of asymmetric turbulent stirring in inner and marginal seas using satellite imagery
Karimova, Svetlana ULg

in International Journal of Remote Sensing (2017), 38(6), 1642-1664

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale ... [more ▼]

For the open ocean, it was already reported on the cyclonic (anticyclonic) asymmetry of appearance of eddies of a certain spatial scale. In this article, we scrutinize the ratios of mostly mesoscale cyclonic and anticyclonic eddies in a number of inner and marginal marine basins, namely in the Baltic, Black, North, and Western Mediterranean Seas. As research material, over 9700 eddy manifestations in the thermal infrared, visible-range, and radar satellite imagery were used. The analysis performed showed that in all the seas the typical and average values of the diameter of anticyclonic eddies were greater than those of cyclonic eddies. The main factor that defines the ratio between anticyclonic and cyclonic eddies in the basins under consideration was discovered to be the intensity of their surface currents. Thus, in the presence of a strong jet flow at the scales of about 2–4 baroclinic Rossby radii the cyclonic eddy dominance typical for smaller eddies was replaced by the anticyclonic one. If strong jet streams were missing, as that typical of the Baltic Sea, cyclonic eddies were prevailing over the entire spectrum of eddy diameters. [less ▲]

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See detailOn Sustainable Aquaculture
Tran Thi Nang, Thu; Lebailly, Philippe ULg

in Oceanography & Fisheries (2017), 1(3), 001-002

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See detailFormaliser le trope : De la subjectivité linguistique à la subjectivité épilinguistique
Mathy, Adrien ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2017)

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See detailIgG4-related disease causing rapid evolution of a severe aortic valvular stenosis
BRULS, Samuel ULg; Courtois, Audrey ULg; DELVENNE, Philippe ULg et al

in The Annals of Thoracic Surgery (2017)

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See detailRecent Advances in Small Clusters and Polymetallic Assemblies Based on Transition Metals and Dithiocarboxylate Zwitterions Derived from N-Heterocyclic Carbenes
Beltran Alvarez, Tomás Francisco ULg; Delaude, Lionel ULg

in Journal of Cluster Science (2017), 28(2), 667-678

N-Heterocyclic carbenes (NHCs) react readily with carbon disulfide to form stable, crystalline, zwitterionic adducts. In this review, we outline the various strategies that were applied to synthesize ... [more ▼]

N-Heterocyclic carbenes (NHCs) react readily with carbon disulfide to form stable, crystalline, zwitterionic adducts. In this review, we outline the various strategies that were applied to synthesize transition metal clusters based on such NHC•CS2 ligands. We also briefly survey their most salient structural features and catalytic properties. Because this research field is still in its infancy, only a limited number of structures containing metals from Group 7 (Mn and Re) and 8 (Fe and Ru) have been described so far. Homo- and heterobimetallic manganese and rhenium carbonyl clusters with the generic formula [MM'(CO)6(mu-kappa2-S,S'-kappa3-S,C,S'-S2C•NHC)] (MM' = Mn2, MnRe, or Re2) were most thoroughly investigated. Isolated examples of dinuclear iron and tetranuclear ruthenium compounds, in which the dithiocarboxylate unit underwent fragmentation, were also reported. Other related polymetallic entities recently elaborated through the use of azolium-2-dithiocarboxylate zwitterions and Group 11 metals (Cu and Au) include copper-based coordination polymers, gold nanoparticles, and self-assembled monolayers. [less ▲]

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See detailAssessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride
Gerardy, Romaric ULg; Winter, Marc; Vizza, Alessandra et al

in Reaction Chemistry and Engineering (2017)

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both ... [more ▼]

The batch-to-flow translation of inter- and intramolecular strategies for the diastereoselective preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride is presented. Both inter- and intramolecular strategies imply the telescoping of multiple processing steps and the generation of unstable diazo species under continuous-flow conditions. The intermolecular strategy relies on an unprecedented continuous-flow Rh-catalyzed intermolecular C–H carbene insertion, providing enriched threo-N-Boc methylphenidate in 38% or 19% isolated yield according to sequential or fully telescoped processes, respectively. Quantitative Boc-deprotection is carried out off-line. The intramolecular strategy relies on a continuous-flow thermal intramolecular C–H carbene insertion, providing enriched threo-methylphenidate hydrochloride in 70% isolated yield. A continuous-flow photochemical alternative is also presented. The critical step of the most promising intramolecular strategy is implemented on the mesoscale in a pilot-scale continuous-flow reactor. [less ▲]

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See detailMetabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach
Govinden-Soulange, J.; Lobine, D.; Frederich, Michel ULg et al

in South African Journal of Botany (2017), 108

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect ... [more ▼]

In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. Nuclear magnetic resonance spectroscopy, DNA sequencing and antioxidant profiles of these Aloes were studied. Principal component analysis following 1H NMR revealed the specificity of the Mascarene Aloes relative to Aloe vera. The superior free radical scavenging ability of A. purpurea, A. macra and A. tormentorii as compared to other Aloes was also unveiled. Phylogenetic analyses of chloroplast genes and ITS region sequences of these Mascarene Aloes were done using maximum parsimony and Bayesian analysis. Mascarene Aloes clustered within one clade separate from Aloe vera confirming their relative recent emergence in this genus. Results from this study showed that there is sufficient evidence at the metabolomic and molecular level to distinguish between Aloe ​purpurea from Mauritius and that of Reunion. © 2016 SAAB [less ▲]

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See detailLa géographie linguistique au nord du domaine d'oïl
Baiwir, Esther ULg

in Bien Dire et Bien Aprandre : Bulletin du Centre d'Etudes Médiévales et Dialectales de l'Université de Lille III (2017), 32

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See detailDeciding game invariance
Duchêne, Eric; Parreau, Aline; Rigo, Michel ULg

in Information & Computation (2017), 253

In a preivous paper, Duchêne and Rigo introduced the notion of invariance for take-away games on heaps. Roughly speaking, these are games whose rulesets do not depend on the position. Given a sequence S ... [more ▼]

In a preivous paper, Duchêne and Rigo introduced the notion of invariance for take-away games on heaps. Roughly speaking, these are games whose rulesets do not depend on the position. Given a sequence S of positive tuples of integers, the question of whether there exists an invariant game having S as set of P -positions is relevant. In particular, it was recently proved by Larsson et al. that if S is a pair of complementary Beatty sequences, then the answer to this question is always positive. In this paper, we show that for a fairly large set of sequences (expressed by infinite words), the answer to this question is decidable. [less ▲]

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See detailMethanol emissions from maize: Ontogenetic dependence to varying light conditions and guttation as an additional factor constraining the flux
Mozaffar, Ahsan ULg; Schoon, N.; Digrado, Anthony ULg et al

in Atmospheric Environment (2017), 152

Because of its high abundance and long lifetime compared to other volatile organic compounds in the atmosphere, methanol (CH3OH) plays an important role in atmospheric chemistry. Even though agricultural ... [more ▼]

Because of its high abundance and long lifetime compared to other volatile organic compounds in the atmosphere, methanol (CH3OH) plays an important role in atmospheric chemistry. Even though agricultural crops are believed to be a large source of methanol, emission inventories from those crop ecosystems are still scarce and little information is available concerning the driving mechanisms for methanol production and emission at different developmental stages of the plants/leaves. This study focuses on methanol emissions from Zea mays L. (maize), which is vastly cultivated throughout the world. Flux measurements have been performed on young plants, almost fully grown leaves and fully grown leaves, enclosed in dynamic flow-through enclosures in a temperature and light-controlled environmental chamber. Strong differences in the response of methanol emissions to variations in PPFD (Photosynthetic Photon Flux Density) were noticed between the young plants, almost fully grown and fully grown leaves. Moreover, young maize plants showed strong emission peaks following light/dark transitions, for which guttation can be put forward as a hypothetical pathway. Young plants’ average daily methanol fluxes exceeded by a factor of 17 those of almost fully grown and fully grown leaves when expressed per leaf area. Absolute flux values were found to be smaller than those reported in the literature, but in fair agreement with recent ecosystem scale flux measurements above a maize field of the same variety as used in this study. [less ▲]

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See detailIn Memoriam Léon Lacroix (1909-2016)
Rochette, Bruno ULg

in Antiquité Classique (2017), 86

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See detailThe lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating ERM proteins activation
Sayyed, Sufyan Ali ULg; JOURET, François ULg; Vermeersch, Marjorie et al

in Kidney International (2017)

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body ... [more ▼]

The microvillus brush border on the renal proximal tubule epithelium allows the controlled reabsorption of solutes that are filtered through the glomerulus and thus participates in general body homeostasis. Here, using the lipid 5-phosphatase Ship2 global knock-out mice, proximal tubule-specific Ship2 knock-out mice and a proximal tubule cell model where SHIP2 is inactivated, we show that SHIP2 is a negative regulator of microvilli formation, thereby controlling solute reabsorption by the proximal tubule. We found increased PtdIns(4,5)P2 substrate and decreased PtdIns4P product when SHIP2 was inactivated, associated with hyperactivated Ezrin/Radixin/Moesin proteins and increased Rho-GTP. Thus, inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule. This may represent an innovative therapeutic target for renal Fanconi syndromes characterized by decreased reabsorption of solutes by this nephron segment. [less ▲]

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See detailFactors associated with reaching or not reaching target HbA1c after initiation of basal or premixed insulin in patients with type 2 diabetes.
Scheen, André ULg; Schmitt, H.; Jiang, H. H. et al

in Diabètes & Métabolism (2017), 43(69-78),

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as ... [more ▼]

AIMS: To evaluate factors associated with reaching or not reaching target glycated haemoglobin (HbA1c) levels by analysing the respective contributions of fasting hyperglycaemia (FHG), also referred to as basal hyperglycaemia, vs postprandial hyperglycaemia (PHG) before and after initiation of a basal or premixed insulin regimen in patients with type 2 diabetes. METHODS: This post-hoc analysis of insulin-naive patients in the DURABLE study randomised to receive either insulin glargine or insulin lispro mix 25 evaluated the percentages of patients achieving a target HbA1c of <7.0% (<53mmol/mol) per baseline HbA1c quartiles, and the effect of each insulin regimen on the relative contributions of PHG and FHG to overall hyperglycaemia. RESULTS: Patients had comparable demographic characteristics and similar HbA1c and FHG values at baseline in each HbA1c quartile regardless of whether they reached the target HbA1c. The higher the HbA1c quartile, the greater was the decrease in HbA1c, but also the smaller the percentage of patients achieving the target HbA1c. HbA1c and FHG decreased more in patients reaching the target, resulting in significantly lower values at endpoint in all baseline HbA1c quartiles with either insulin treatment. Patients not achieving the target HbA1c had slightly higher insulin doses, but lower total hypoglycaemia rates. CONCLUSION: Smaller decreases in FHG were associated with not reaching the target HbA1c, suggesting a need to increase basal or premixed insulin doses to achieve targeted fasting plasma glucose and improve patient response before introducing more intensive prandial insulin regimens. [less ▲]

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See detailComparison of metabolic profiles and bioactivities of the leaves of three edible Congolese Hibiscus species
Kapepula, Paulin Mutwale; Kabamba Ngombe, Nadege; Tshisekedi Tshibangu, Pascal et al

in Natural Product Research (2017), 6419(March), 1--8

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See detailEffects of non-invasive vagus nerve stimulation on attack frequency over time and expanded response rates in patients with chronic cluster headache: a post hoc analysis of the randomised, controlled PREVA study
Gaul, Charly; MAGIS, Delphine ULg; Liebler, Eric et al

in Journal of Headache and Pain (2017), 18

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve ... [more ▼]

Background: In the PREVention and Acute treatment of chronic cluster headache (PREVA) study, attack frequency reductions from baseline were significantly more pronounced with non-invasive vagus nerve stimulation plus standard of care (nVNS + SoC) than with SoC alone. Given the intensely painful and frequent nature of chronic cluster headache attacks, additional patient-centric outcomes, including the time to and level of therapeutic response, were evaluated in a post hoc analysis of the PREVA study. Findings: After a 2-week baseline phase, 97 patients with chronic cluster headache entered a 4-week randomised phase to receive nVNS + SoC (n = 48) or SoC alone (n = 49). All 92 patients who continued into a 4-week extension phase received nVNS + SoC. Compared with SoC alone, nVNS + SoC led to a significantly lower mean weekly attack frequency by week 2 of the randomised phase; the attack frequency remained significantly lower in the nVNS + SoC group through week 3 of the extension phase (P < 0.02). Attack frequencies in the nVNS + SoC group were significantly lower at all study time points than they were at baseline (P < 0.05). Response rates were significantly greater with nVNS + SoC than with SoC alone when response was defined as attack frequency reductions of ≥25%, ≥50%, and ≥75% from baseline (≥25% and ≥50%, P < 0.001; ≥75%, P = 0.009). The 100% response rate was 8% with nVNS + SoC and 0% with SoC alone. Conclusions: Prophylactic nVNS led to rapid, significant, and sustained reductions in chronic cluster headache attack frequency within 2 weeks after its addition to SoC and was associated with significantly higher ≥25%, ≥50%, and ≥75% response rates than SoC alone. The rapid decrease in weekly attack frequency justifies a 4-week trial period to identify responders to nVNS, with a high degree of confidence, among patients with chronic cluster headache. [less ▲]

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See detailEvaluation d'un itinéraire clinique pour collectomie gauche en chirurgie abdominale
Mattart, Laurine; Stevens, Marie; Magis, David ULg et al

in Revue Médicale de Liège (2017), 72(1), 45-50

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne ... [more ▼]

Fin 2008, l’itinéraire clinique (IC) «colectomie gauche» a été mis en place au sein de la Clinique Saint-Joseph (CHC) de Liège. Une série de 213 patients présentant une pathologie bénigne ou maligne nécessitant une résection du côlon gauche par laparoscopie a été incluse dans cet IC entre 2009 et 2015. Nous nous sommes intéressés à l’observance du protocole de l’IC ainsi qu’aux taux de complications et de ré-hospitalisations dans les 30 jours post-opératoires. Nous avons constaté, après comparaison avec un groupe témoin historique, que l’adhésion au protocole IC a été d’emblée excellente (> 80 %) tout au long de la durée de l’étude. Il n’y a pas eu de modification du taux de ré-hospitalisations et le taux de lâchage de suture a été réduit. Bien que la diminution de la durée de séjour n’était pas l’objectif premier lors de la mise en place de cet IC, elle s’est significativement réduite passant, en moyenne, de 8 à 4 jours. En conclusion, l’introduction d’un IC, pour autant qu’il soit bien préparé et rassemble dans le même objectif l’ensemble des acteurs de soins, est directement bénéfique pour le patient et la qualité de sa prise en charge. [less ▲]

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See detailAre Th17 Cells Playing a Role in Immunity to Dermatophytosis?
Heinen, Marie-Pierre ULg; Cambier, Ludivine ULg; Fievez, Laurence ULg et al

in Mycopathologia (2017), 182(1), 251-261

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See detailSedimentologic and paleoclimatic reconstructions of carbonate factory evolution in the Alborz Basin (northern Iran) indicate a global response to Early Carboniferous (Tournaisian) glaciations
Sardar Abadi, Mehrdad; Kulagina, E.; Voeten, D.F.A.E. et al

in Sedimentary Geology (2017), 348

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See detailTransdifferentiation of Neuroendocrine Cells: Gangliocytoma Associated With Two Pituitary Adenomas of Different Lineage in MEN1.
Sergeant, Camille; Jublanc, Christel; Leclercq, Delphine et al

in American Journal of Surgical Pathology (2017)

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a ... [more ▼]

Gangliocytomas are rare and benign neuronal cell tumors, mostly found in the hypothalamic and sellar regions. Their histogenesis is still the subject of discussions. Herein we present a unique case of a pituitary gangliocytoma associated with a prolactinoma and a corticotroph adenoma in a patient affected by MEN1. The histologic study revealed shared features between adenomatous and neuronal cells, supporting the etiological hypothesis of a common origin or a phenomenon of transdifferentiation. Furthermore, gangliocytoma could be a new tumor related to MEN1. The clinical and histologic observations are discussed and the literature on the topic is reviewed. [less ▲]

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See detailMacroevolution of Specificity in Cyanolichens of the Genus Peltigera Section Polydactylon (Lecanoromycetes, Ascomycota)
Magain, Nicolas ULg; Miadlikoswka, Jolanta; Goffinet, Bernard et al

in Systematic Biology (2017), 66(1), 74-99

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See detailPreparing physically educated citizens in physical education. Expectations and practices
Cloes, Marc ULg

in Retos (2017), 31

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being ... [more ▼]

Since physical education (PE) became a compulsory school subject, its objectives have often been related to the expectations of society. Since the turn of the new millennium, this has resulted in PE being increasingly linked to the promotion of physically active lifestyles. In this paper, we try to determine whether practitioners have the capacity to reach recent objectives for the subject or should reconsider their work on this issue. Moreover, we propose to extend the current focus on physical literacy to encompass the concept of societal transfer, underlining the need for an authentic pedagogy of PE. [less ▲]

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See detailAllogeneic stem cell transplantation for patients with myelodysplastic syndrome 70 years of age or older: A retrospective study of the MDS subcommittee of the Chronic Malignancies Working Party (CMWP) of the EBMT
Heidenreich, S; Ziagkos, D; De Wreede, L et al

in Biology of Blood & Marrow Transplantation (2017), 23

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n ... [more ▼]

In this retrospective analysis we evaluated the outcome of 313 patients aged ≥ 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. Median age at HSCT was 72 years (range, 70 to 78). Conditioning regimen was nonmyeloablative (n = 54), reduced intensity (n = 207), or standard intensity (n = 52). Allogeneic HSCT for MDS patients ≥ 70 years was increasingly performed over time. Although during 2000 to 2004 only 16 patients received HSCT, during 2011 to 2013 the number of transplantations increased to 181. The cumulative incidence of nonrelapse mortality at 1 year and relapse at 3 years was 32% and 28%, respectively, with a 3-year overall survival rate of 34%. Good performance, determined by Karnofsky performance status, and recipients’ seronegativity for cytomegalovirus was associated with 3-year estimated overall survival rates of 43% (P = .01) and 46% (P = .002), respectively. Conditioning intensity did not impact survival. After careful patient selection, allogeneic HSCT can be offered to patients older than 70 years with MDS. [less ▲]

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See detailFactors controlling spatial and temporal patterns of multiple pesticide compounds in groundwater (Hesbaye chalk aquifer, Belgium)
Hakoun, Vivien; Orban, Philippe ULg; Dassargues, Alain ULg et al

in Environmental Pollution (2017)

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To ... [more ▼]

Factors governing spatial and temporal patterns of pesticide compounds (pesticides and metabolites) concentrations in chalk aquifers remain unclear due to complex flow processes and multiple sources. To uncover which factors govern pesticide compound concentrations in a chalk aquifer, we develop a methodology based on time series analyses, uni- and multivariate statistics accounting for concentrations below detection limits. The methodology is applied to long records (1996–2013) of a restricted compound (bentazone), three banned compounds (atrazine, diuron and simazine) and two metabolites (deethylatrazine (DEA) and 2,6–dichlorobenzamide (BAM)) sampled in the Hesbaye chalk aquifer in Belgium. In the confined area, all compounds had non-detects fractions >80%. By contrast, maximum concentrations exceeded EU’s drinking-water standard (100 ngL-1) in the unconfined area. This contrast confirms that recent recharge and polluted water did not reach the confined area, yet. Multivariate analyses based on variables representative of the hydrogeological setting revealed higher diuron and simazine concentrations in the southeast of the unconfined area, where urban activities dominate land use and where the aquifer lacks protection from a less permeable layer of hardened chalk. At individual sites, positive correlations (up to τ =0,48 for bentazone) between pesticide compound concentrations and multi-annual groundwater level fluctuations confirm occurrences of remobilization. A downward temporal trend of atrazine concentrations likely reflects decreasing use of this compound over the last 28 years. However, the lack of a break in concentrations time series and maximum concentrations of atrazine, simazine, DEA and BAM exceeding EU’s standard post-ban years provide evidence of persistence. Contrasting upward trends in bentazone concentrations show that a time lag is required for restriction measures to be efficient. These results shed light on factors governing pesticide compound concentrations in chalk aquifers. The developed methodology is not restricted to chalk aquifers, it could be transposed to study other pollutants with concentrations below detection limits. Several factors govern pesticide compounds concentrations in the chalk: hydrogeological setting, land use, groundwater level fluctuations and persistence. [less ▲]

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See detailExperimental observation of the Poincaré-Birkhoff scenario in a driven many-body quantum system
Tomkovic, Jiri; Muessel, Wolfgang; Strobel, Helmut et al

in Physical Review A (2017), 95

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See detailA vertebrate specific and essential role for sp7/osterix in osteogenesis revealed by gene knock-out in the teleost medaka.
Yu, T; Graf, M; Renn, Jörg ULg et al

in Development (2017), 144(2), 265-271

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation ... [more ▼]

Sp7/osterix (osx) encodes a zinc-finger transcription factor that controls osteoblast differentiation in mammals. Although identified in all vertebrate lineages, its role in non-mammalian bone formation remains elusive. Here we show that an osx mutation in medaka results in severe bone defects and larval lethality. Pre-osteoblasts fail to differentiate leading to severe intramembranous and perichondral ossification defects. The notochord sheath mineralizes normally supporting the idea of an osteoblast-independent mechanism for teleost vertebral centra formation. This study establishes a key role for Sp7/Osx for bone formation also in a non-mammalian species, and reveals conserved and non-conserved features in vertebrate bone formation. [less ▲]

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See detailRoad and intermodal transport performance: the impact of operational costs and air pollution external costs
Mostert, Martine ULg; Caris, An; Limbourg, Sabine ULg

in Research in Transportation Business & Management (2017)

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that ... [more ▼]

The transportation of goods is essential for the economy, but it also contributes to air pollution which, in turn, affects human health. These negative impacts generate additional costs for society that are not necessarily taken into account in public transportation policies and in private transportation decisions of companies and individuals. This leads to inefficient transportation systems where the social equilibrium is not reached. Intermodal transport is promoted by the European Commission to reduce these negative externalities. The objective of this paper is to analyze at a strategic level the effect on modal split between road, intermodal rail and intermodal inland waterway transport of several economic or environmental policies. An intermodal allocation model is applied to the Belgian case in order to identify the modal split changes between the single minimization of costs (operational or health-related external) and the introduction of additional road taxes. [less ▲]

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See detailFluvial archives, a valuable record of vertical crustal deformation
Demoulin, Alain ULg; Mather, Anne; Whittaker, Alexander

in Quaternary Science Reviews (2017)

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature ... [more ▼]

The study of drainage network response to uplift is important not only for understanding river system dynamics and associated channel properties and fluvial landforms, but also for identifying the nature of crustal deformation and its history. In recent decades, geomorphic analysis of rivers has proved powerful in elucidating the tectonic evolution of actively uplifting and eroding orogens. Here, we review the main recent developments that have improved and expanded qualitative and quantitative information about vertical tectonic motions (the effects of horizontal deformation are not addressed). Channel long profiles have received considerable attention in the literature, and we briefly introduce basic aspects of the behaviour of bedrock rivers from field and numerical modelling perspectives, before describing the various metrics that have been proposed to identify the information on crustal deformation contained within their steady-state characteristics. Then, we review the literature dealing with the transient response of rivers to tectonic perturbation, through the production of knickpoints propagating through the drainage network. Inverse modelling of river profiles for uplift in time and space is also shown to be very effective in reconstructing regional tectonic histories. Finally, we present a synthetic morphometric approach for deducing the tectonic record of fluvial landscapes. As well as the erosional imprint of tectonic forcing, sedimentary deposits, such as fluvial terrace staircases, are also considered as a classical component of tectonic geomorphology. We show that these studies have recently benefited from rapid advances in dating techniques, allowing more reliable reconstruction of incision histories and estimation of incision rates. The combination of progress in the understanding of transient river profiles and larger, more rigorous data sets of terrace ages has led to improved understanding of river erosion and the implications for terrace profile correlation, i.e., extrapolation of local data to entire profiles. Finally, planform changes in fluvial systems are considered at the channel scale in alluvial rivers and regional level in terms of drainage reorganisation. Examples are given of how numerical modelling can efficiently combine with topographic data to shed new light on the (dis)equilibrium state of drainage systems across regional drainage divides. [less ▲]

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See detailFuture-oriented mental time travel in individuals with disordered gambling.
Noel, Xavier; Saeremans, Melanie; Kornreich, Charles et al

in Consciousness & Cognition (2017), 49

This study investigated the ability of individuals with disordered gambling to imagine future events. Problem gamblers (n=35) and control participants (n=35) were asked to imagine positive and negative ... [more ▼]

This study investigated the ability of individuals with disordered gambling to imagine future events. Problem gamblers (n=35) and control participants (n=35) were asked to imagine positive and negative future events for three temporal distances (one week, one year, 5-10years). Then, a variety of phenomenological aspects of their future thoughts (e.g., sensory and contextual details, autonoetic consciousness) were rated. Compared to control subjects, problem gamblers generated fewer positive and negative events across all temporal distances, an impairment that was correlated to verbal fluency scores. Furthermore, problem gamblers rated imagined events as containing fewer sensory and contextual details, and lacking autonoetic consciousness. These findings demonstrate that problem gambling is associated with a reduced future-oriented mental time travel ability and, in particular, with diminished autonoetic consciousness when imagining future events. [less ▲]

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See detailSartre, le XXe siècle
Cormann, Grégory ULg

in Médium (2017), 50

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See detailFamilial history of migraine influences habituation of visual evoked potentials
Lisicki Martinez, Marco ULg; Ruiz-Romagnoli, Emiliano; D'Ostilio, Kevin ULg et al

in Cephalalgia : An International Journal of Headache (2017)

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation ... [more ▼]

Background: Lack of habituation of visual evoked potentials (VEP) is a common finding in migraine patients between attacks. Previous studies have suggested an electrophysiological familial aggregation pattern associated with migraine. The aim of this study was to evaluate the influence of a positive familial history of migraine on VEP amplitude and habituation. Methods: We recorded six blocks of 100 VEP during continuous pattern-reversal stimulation in 30 patients with migraine between attacks (MO) and in 30 healthy volunteers, of whom 15 had a first-degree relative suffering from migraine (HVm) and 15 had not (HV). Results: Both MO and HVm had a significant deficit of VEP habituation and similarly reduced N1-P1 first block amplitudes, compared to HV (habituation slope: MO ¼ 0.033, HVm ¼ 0.021, HV ¼ 0.025, HV vs. MO p ¼ 0.002, HV vs. HVm p ¼ 0.036; mean N1-P1 amplitude in the first block: MO ¼ 9.08 mV, HVm ¼ 9.29 mV, HV ¼ 12.19 mV. HV vs. MO p ¼ 0.041, HV vs. HVm p ¼ 0.076). The first block N1-P1 amplitude was negatively correlated with the habituation slope for both MO (r ¼ .44, p ¼ 0.015) and HVm (r ¼ .56, p ¼ 0.031) while no significant correlation was found in HV (r ¼ .17, p ¼ 0.53). There were no differences in VEP latencies between the groups. Conclusions: Our study suggests that lack of habituation of visual evoked potentials is probably a genetically determined endophenotypic trait that is associated with both migraine and migraine susceptibility. We hypothesize that genetic diversity of populations could account for some of the discrepancies between electrophysiological studies performed in migraine and for interindividual variations among the subgroups. [less ▲]

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See detailOrganic Farming and Small-Scale Farmers: Main Opportunities and Challenges
Jouzi, Zeynab; Azadi, Hossein ULg; Taheri, Fatemeh et al

in Ecological Economics (2017), 132(February 2017), 144-154

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we ... [more ▼]

Producing enough food to meet the needs of a growing population has always been the greatest concern of food policy-makers around the world. Given the increasing attention to organic farming (OF), we conducted this study to investigate the main opportunities and challenges of the food production system of small-scale farmers in developing countries with an emphasis on their livelihoods. The study showed that the most significant advantages of OF are environmental protection and a higher resilience to environmental changes, increasing farmers' income and reducing external input cost, enhancing social capacity and increasing employment opportunities. A s well as enhancing food security primarily by increasing the food purchasing power of local people. However, the main challenges of this food production system include lower yields in comparison to conventional systems, difficulties with soil nutrient management, certification and market barriers, and the educational and research needs of small-holders. The paper concludes that even though OF might present some significant challenges to small-scale farmers, it could/should still be considered as a part of the solution and means of improving their livelihoods. [less ▲]

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See detailPest regulation and support of natural enemies in agriculture: Experimental evidence of within field wildflower strips
Hatt, Séverin ULg; Chevalier Mendes Lopes, Thomas ULg; Boeraeve, Fanny ULg et al

in Ecological Engineering (2017), 98

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for ... [more ▼]

tRestoring ecosystem services in agriculture is vital to reach a sustainable food production. More specif-ically, developing farming practices which enhance biological pest control is a main issue for today’sagriculture. The aim of this study was to assess whether the two strategies of complicating the search ofhost plants by pests by increasing plant diversity, and of supporting their natural enemies by managinghabitats, could be combined simultaneously at the field scale to restore biological pest control and reducechemical insecticide use. In Gembloux (Belgium), wildflower strips (WFS) were sown within wheat cropsin which pests (i.e., aphids), their predators (i.e. aphidophagous hoverflies, lacewings and ladybeetles)and parasitoid wasps were monitored for 10 weeks in the period of May through July 2015 as indicatorsof the ES of pest control. Aphids were significantly reduced and adult hoverflies favoured in wheat inbetween WFS, compared to monoculture wheat plots. No significant differences were observed for adultlacewings, ladybeetles and parasitoids. In all treatments, very few lacewing and ladybeetle larvae wereobserved on wheat tillers. The abundance of hoverfly larvae was positively correlated with the aphid den-sity on tillers in between WFS, showing that increasing food provisions by multiplying habitats withinfields, and not only along margins, can help supporting aphidophagous hoverflies in crops. By enhancingthe ecosystem services of biological pest control, this study shows that increasing both plant diversityand managing habitats for natural enemies may reduce aphid populations, hence insecticide use. Futureresearch should continue this vein of work by quantifying the link between agricultural practices and thedelivery of ecosystem services in order to guide future measures of agricultural policies. [less ▲]

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See detailA nonlinear state-space approach to hysteresis identification
Noël, Jean-Philippe ULg; Esfahani, Alireza; Kerschen, Gaëtan ULg et al

in Mechanical Systems & Signal Processing (2017), 84

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an ... [more ▼]

Most studies tackling hysteresis identification in the technical literature follow white-box approaches, i.e. they rely on the assumption that measured data obey a specific hysteretic model. Such an assumption may be a hard requirement to handle in real applications, since hysteresis is a highly individualistic nonlinear behaviour. The present paper adopts a black-box approach based on nonlinear state-space models to identify hysteresis dynamics. This approach is shown to provide a general framework to hysteresis identification, featuring flexibility and parsimony of representation. Nonlinear model terms are constructed as a multivariate polynomial in the state variables, and parameter estimation is performed by minimising weighted least-squares cost functions. Technical issues, including the selection of the model order and the polynomial degree, are discussed, and model validation is achieved in both broadband and sine conditions. The study is carried out numerically by exploiting synthetic data generated via the Bouc-Wen equations. [less ▲]

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See detailOn the numerical simulation of sheet metal blanking process
Canales Cardenas, Cristian ULg; Bussetta, Philippe; Ponthot, Jean-Philippe ULg

in International Journal of Material Forming (2017), 10

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and ... [more ▼]

The use of the blanking process has been widely spread in mass production industries. In this technique, the quality of the final product is directly related to the setting parameters of the process and the material response of the sheet. In the present work, a general framework based on the finite element method for the simulation of the sheet metal blanking process is presented. The proposed approach properly addresses all the numerical challenges related to blanking. First, an extension of elasto-viscoplastic constitutive equations for the large strain regime is used to take into account the material strain-rate sensitivity. Then, the inertial effects coming from high velocity operations are considered by means of an implicit time integration scheme. Moreover, the frictional contact interactions are simulated with the classical Coulomb law and an energetically consistent formulation of area regularization. Finally, ductile fracture is modeled thanks to the element deletion method coupled with a fracture criterion. The blanking process is then simulated for different setting parameters. The accuracy of this approach is evaluated by comparing the numerical predictions to experimental results for both quasi-static and dynamic conditions. Good agreement is found between experimental and numerical results for all cases. [less ▲]

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See detailEffects of isolated versus combined learning enactments in an online course
Verpoorten, Dominique ULg; Westera, Wim; Specht, Marcus

in International Journal of Technology Enhanced Learning (2017)

In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations ... [more ▼]

In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations. Results show no difference in performance between groups when annotation behaviour is considered in isolation. However, analyses conducted within treatments provide indications of a positive impact on performance when annotation rates are taken into consideration, and coupled with other enactments tracked in the course. Combined in engagement profiles (Learning DNAs), these enactments suggest that what makes active learning efficient might be an ongoing crisscrossing between a firstorder learning activity (the study of the course) and a series of second order activities, such as making notes. Students who manage to coordinate these activities at a higher rate perform better. This observation opens a line of reasoning about what determines the quality of a mental engagement in a learning task, in terms of balance and rotation of cognitive and metacognitive operations. [less ▲]

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See detailIntentionalisme et phénoménologie de l'intentionnalité
Seron, Denis ULg

in Etudes Phénoménologiques - Phenomenological Studies (2017), 1

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of ... [more ▼]

This paper presents an argument in favor of a “phenomenological” approach to intentionality. This approach, as I see it, involves the view that intentional facts are better expressed with the help of appearance words (“seems”, “appears”, “is similar to”, etc.). By contrast, what I call the “intentionalist approach” assumes that intentional facts are better expressed by intentional verbs. The argument is as follows. First, it is well-known that the use of intentional verbs to express typically intentional facts generates anomalies with respect to existential generalization, substitution of identicals, and the principle of excluded middle. Secondly, I argue that the use of appearance words does not generate the same anomalies, which suggests that appearance words are more appropriate to describe intentional facts. This, I conclude, is an argument for preferring the phenomenological to the intentionalist approach to intentionality. [less ▲]

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See detailAeroservoelastic Simulations for Horizontal Axis Wind Turbines
Prasad, Chandra Shekhar ULg; Chen, Qiong Zhong; Bruls, Olivier ULg et al

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (2017), 231(2), 103-117

This paper describes the development of a complete methodology for the aeroservoelastic modeling of horizontal axis wind turbines at the conceptual design stage. The methodology is based on the ... [more ▼]

This paper describes the development of a complete methodology for the aeroservoelastic modeling of horizontal axis wind turbines at the conceptual design stage. The methodology is based on the implementation of unsteady aerodynamic modeling, advanced description of the control system and nonlinear finite element calculations in the SWT wind turbine design package. The aerodynamic modeling is carried out by means of fast techniques, such as the Blade Element Method and the unsteady Vortex Lattice Method, including a free wake model. The complete model also includes a description of a doubly fed induction generator and its control system for variable speed operation. The SWT software features a non-linear finite element solver with multi-body dynamics capability. The full methodology is used to perform complete aeroservoelastic simulations of a realistic 2MW wind turbine model. The interaction between the three components of the approach is carefully analyzed and presented here. [less ▲]

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See detailPoor Performance of a Retrofitted Downstream Bypass Revealed by the Analysis of Approaching Behaviour in Combination with a Trapping System
Ovidio, Michaël ULg; Dierckx, Arnaud ULg; Bunel, Sarah et al

in River Research & Applications (2017), 33

The implementation of fish downstream migration bypass systems is still a major challenge, and there is interest in validating the adequacy of different configurations of bypass devices. In the Amblève ... [more ▼]

The implementation of fish downstream migration bypass systems is still a major challenge, and there is interest in validating the adequacy of different configurations of bypass devices. In the Amblève River (Belgium), a mobile 3.3-m height dam feeds two principal Francis and one Francis micro-turbine and is equipped with a modern vertical slot fish pass and a downstream bypass. The aim of this study was to test the bypass attraction and efficiency (i.e. percentage of fish that approach the entrance and use the bypass) for Atlantic salmon smolts. During three consecutive years, a total of 1346 smolts were equipped with a radio frequency identification tag and released from March to May upstream of the dam of Lorcé. The entrance of the downstream migration bypass was equipped with a radio frequency identification antenna in order to detect the smolts approaching. In 2014, a capture cage was also placed downstream the bypass to evaluate its efficiency. The mean percentage of detected smolts at the entrance varied from 26.2 to 39.7%. In 2014, 16.5% of the released smolts entered the bypass and were finally caught in the cage, representing 39% of the smolts detected at the entrance. More than 98% of the detections occurred during night (mainly between 9 PM and 3 AM). The searching delay near the bypass entrance varied from less than 5 min to more than 5 days (median 4.3 min). Visual observation indicated a behavioural reluctance before entering the bypass, with a shift from positive to negative rheotaxy. Our results underline the difficulty to install retrofitted bypass system on old existing hydropower plants. Copyright © 2016 John Wiley & Sons, Ltd. [less ▲]

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See detailPhotoreversibility and biocompatibility of polydimethylsiloxane-coumarin as adjustable intraocular lens material
Jellali, Rachid; Bertrand, Virginie ULg; Alexandre, Michaël et al

in Macromolecular Bioscience (2017)

Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a ... [more ▼]

Polydimethylsiloxane (PDMS) constitutes an interesting material for a variety of biomed- ical applications, especially as intraocular lenses (IOLs), for its excellent transparency. In this work, a photoreversible PDMS-coumarin network, whose shape and properties can be adjusted postoperatively in a noninvasive manner, is developed. The synthesis of PDMS-cou- marin is achieved by amidation of a coumarin acid chloride derivative with amine-function- alized PDMSs. Under exposure of λ > 300 nm, these polymers can be cured by dimerization of coumarin. The cured polymers can be uncrosslinked via photocleavage of cyclobutane dimers upon illumination at λ < 290 nm. The diffusion of linear PDMSs in a crosslinked network and the controlled shape modification are studied, which demonstrate that these polymers are good candidates for adjustable IOL application. IOL disks prepared from these materials show high hydrophobicity and good transparency. In vitro cytotoxicity, lens epithelial cell adhesion assays, and rabbit host reaction against implanted disks demonstrate the biocompatibility of the polymer. [less ▲]

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See detailPercevoir et reconnaître des symboles : La théorie de la représentation iconique de Dominic Lopes
Hagelstein, Maud ULg

in Bulletin d'Analyse Phénoménologique (2017)

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily ... [more ▼]

In his works on the epistemological value of images (Understanding Pictures — 1996), Dominic Lopes (Department of Philosophy — University of British Columbia) develops an analytical aesthetics primarily concerned with iconic representation. His analysis distinguishes two models of iconic representation comprehension. In the first model, inspired by perceptual approaches like that of Richard Wollheim, the process of image recognition is rooted in perception (to sum it up: perceptualism embraces the idea of « likeness » between the image and what it represents). One of this model’s shortcomings, however, is that it too readily assumes that perception can be a natural, straightforward process. Indeed, iconic representation can not be understood through perception alone, as vision is of course influenced by cultural and, most of all, cognitive processes. A representative model thus needs to account for the ways in which iconic recognition differs from ordinary visual recognition. In the second model, which build off of symbolic approaches like that of Nelson Goodman, iconic representation works the same way as other types of symbols, particularly linguistic ones. Thus, this approach considers the similarities between images and language (representations which are both affected by processes of denotation and predication). However, we all know how strongly image theoreticians have been resisting the linguistic paradigm (iconic turn topic): some worry about overlooking the image’s semantic density in favor of its « simple » descriptive quality. Lopes finds a path between these two models by developing a « theory of aspect recognition », which incorporates perceptive elements into a symbolic structure. According to Lopes, if we agree that images belong to symbolic systems of denotation, then « they might be symbols for which the reference is dependent on the carrying out of perceptive aptitudes », a claim which my talk will explore. I will also discuss how Lopes’ theory accounts for skills acquisition (the capacity to recognize) through images, and shows how images help these skills progressively develop. [less ▲]

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See detailLe colloque Francarbi à Bruxelles : le principe du contradictoire en arbitrage
Caprasse, Olivier ULg

in Journal des Tribunaux (2017)

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See detailScale-dependent diffusion anisotropy in nanoporous silicon
Kondrashova, D; Lauerer, A; Mehlhorn, D et al

in Scientific Reports (2017), 7

Nanoporous silicon produced by electrochemical etching of highly B-doped p-type silicon wafers can be prepared with tubular pores imbedded in a silicon matrix. Such materials have found many technological ... [more ▼]

Nanoporous silicon produced by electrochemical etching of highly B-doped p-type silicon wafers can be prepared with tubular pores imbedded in a silicon matrix. Such materials have found many technological applications and provide a useful model system for studying phase transitions under con nement. This paper reports a joint experimental and simulation study of di usion in such materials, covering displacements from molecular dimensions up to tens of micrometers with carefully selected probe molecules. In addition to mass transfer through the channels, di usion (at much smaller rates) is also found to occur in directions perpendicular to the channels, thus providing clear evidence of connectivity. With increasing displacements, propagation in both axial and transversal directions is progressively retarded, suggesting a scale-dependent, hierarchical distribution of transport resistances (“constrictions” in the channels) and of shortcuts (connecting “bridges”) between adjacent channels. The experimental evidence from these studies is con rmed by molecular dynamics (MD) simulation in the range of atomistic displacements and rationalized with a simple model of statistically distributed “constrictions” and “bridges” for displacements in the micrometer range via dynamic Monte Carlo (DMC) simulation. Both ranges are demonstrated to be mutually transferrable by DMC simulations based on the pore space topology determined by electron tomography. [less ▲]

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See detailMiddle Miocene climate and vegetation models and their validation with proxy data
Henrot, Alexandra-Jane ULg; Utescher, Torsten; Erdei, Boglarka et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2017), 467

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See detailTroubles du comportement alimentaire et régulation émotionnelle
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2017), 7

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See detailL’ÉVALUATION DES POLITIQUES PUBLIQUES DANS LE CHAMP DE LA COOPÉRATION AU DÉVELOPPEMENT BELGE : LE CAS DU SERVICE DE L’ÉVALUATION SPÉCIALE
Contor, Justine ULg

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2017)

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation ... [more ▼]

Cette contribution s’intéresse à l'évolution institutionnelle de l'évaluation au sein de la coopération belge au développement et plus spécifiquement à notre cas d’étude : le Service de l’Evaluation Spéciale de la coopération belge au développement (SES). Nous présenterons dans ce document les raisons de la création de ce service au début des années 2000. En effet, le SES, avec d’autres acteurs, est le résultat d’une grande réforme de la coopération issue d’une lourde crise. Nous reviendrons sur son mandat, sur ses spécificités organisationnelles (ressources financières et humaines) ainsi que son cadre de référence normatif. La question de la culture évaluative sera questionnée, ainsi que son lien avec l’émergence du New Public Management dans la politique de coopération au développement. Enfin, nous questionnerons la légitimité d’une structure telle que le SES au regard d’un cadrage théorique mixte (Scott, 1995 ; Suchmann, 1995) et de la théorie des parties prenantes. [less ▲]

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See detailSedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity.
KIRSCH, Murielle ULg; Guldenmund, P; Ali Bahri, Mohamed et al

in Anesthesia and Analgesia (2017), 124(2),

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See detailProteomic signatures reveal a dualistic and clinically relevant classification of anal canal carcinoma
Herfs, Michael ULg; Longuespée, Rémi ULg; Quick, Charles et al

in Journal of Pathology (The) (2017), 241

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See detailPitfalls in supermatrix phylogenomics
Philippe, Hervé; Vienne, Damien M. De; Ranwez, Vincent et al

in European Journal of Taxonomy (2017), 283

In the mid-2000s, molecular phylogenetics turned into phylogenomics, a development that improved the resolution of phylogenetic trees through a dramatic reduction in stochastic error. While some then ... [more ▼]

In the mid-2000s, molecular phylogenetics turned into phylogenomics, a development that improved the resolution of phylogenetic trees through a dramatic reduction in stochastic error. While some then predicted “the end of incongruence”, it soon appeared that analysing large amounts of sequence data without an adequate model of sequence evolution amplifies systematic error and leads to phylogenetic artefacts. With the increasing flood of (sometimes low-quality) genomic data resulting from the rise of high-throughput sequencing, a new type of error has emerged. Termed here “data errors”, it lumps together several kinds of issues affecting the construction of phylogenomic supermatrices (e.g., sequencing and annotation errors, contaminant sequences). While easy to deal with at a single-gene scale, such errors become very difficult to avoid at the genomic scale, both because hand curating thousands of sequences is prohibitively time-consuming and because the suitable automated bioinformatics tools are still in their infancy. In this paper, we first review the pitfalls affecting the construction of supermatrices and the strategies to limit their adverse effects on phylogenomic inference. Then, after discussing the relative non-issue of missing data in supermatrices, we briefly present the approaches commonly used to reduce systematic error. [less ▲]

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See detailComparison of clinical effects of epidural levobupivacaine morphine versus bupivacaine morphine in dogs undergoing elective pelvic limb surgery
Cerasoli, Ilaria; Tutunaru, Alexandru-Cosmin ULg; Cenani, Alessia et al

in Veterinary Anaesthesia & Analgesia (2017)

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See detailEfficient ANOVA for directional data
Ley, Christophe; Swan, Yvik ULg; Verdebout, Thomas

in Annals of the Institute of Statistical Mathematics (2017)

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See detailEffects of reducing blood pressure on renal outcomes in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.
Scheen, André ULg; Delanaye, P.

in Diabètes & Métabolism (2017), (epub ahead of print),

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 ... [more ▼]

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function. While systemic BP reduction associated to empagliflozin therapy may have contributed to the renal benefits reported in EMPA-REG OUTCOME, other local mechanisms related to kidney homoeostasis most probably also played a role in the overall protection observed in the trial. [less ▲]

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See detailA water retention model for compacted bentonites
Dieudonné, Anne-Catherine ULg; Della Vecchia, Gabriele; Charlier, Robert ULg

in Canadian Geotechnical Journal (2017)

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See detailNew computational method of the ball/race contacts transverse loads of high speed ball bearings without race control hypothesis
Servais, Christophe ULg

in Tribology International (2017)

Some hypotheses are still necessary in order to access the ball bearing Newtonian equilibrium with quasi-static methods. Among these hypotheses are the values of the transverse loads within ball/race ... [more ▼]

Some hypotheses are still necessary in order to access the ball bearing Newtonian equilibrium with quasi-static methods. Among these hypotheses are the values of the transverse loads within ball/race contacts. Those loads are due to the gyroscopic torques. Nowadays, the transverse loads are estimated without any equilibrium criterion by the specialized literature. Moreover, the race control assumption is often employed in addition to the hypotheses made about the transverse loads. The paper describes a new method to compute the transverse loads without using the race control assumption. Then, a correlation between the ball bearing kinematics and the transverse loads is established. It leads to an accurate and efficient computational method to access the Newtonian equilibrium of high speed ball bearings. [less ▲]

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See detailPest and mould infestation of smoked shrimp and preventive measures for storage in cottage industry
Kpoclou; Anihouvi; Azokpota et al

in Indian Journal of Traditional Knowledge (2017), 16

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See detailDo flower mixtures with high functional diversity enhance aphid predators in wildflower strips?
Hatt, Séverin ULg; Uyttenbroeck, Roel ULg; Chevalier Mendes Lopes, Thomas ULg et al

in European Journal of Entomology (2017), 114

Among semi-natural elements in agricultural landscapes, wildflower strips sown at field margins or within fields represent potential habitats for the natural enemies of insect pests. As insects are ... [more ▼]

Among semi-natural elements in agricultural landscapes, wildflower strips sown at field margins or within fields represent potential habitats for the natural enemies of insect pests. As insects are sensitive to a variety of flower traits, we hypothesised that mixtures with high functional diversity attract and support a higher abundance and species richness of aphid flower visiting predators compared to mixtures with low functional diversity. During a field experiment, repeated over two years (2014 and 2015) in Gembloux (Belgium), aphid predators (i.e., lacewings, ladybeetles and hoverflies) were pan-trapped in five sown flower mixtures (including a control mixture, with three replicates of each mixture) of low to high functional diversity based on seven traits (i.e., flower colour, ultra-violet reflectance and pattern, blooming start and duration, height and flower class, primarily based on corolla morphology). In both years, flower species in the sown mixtures (i.e., sown and spontaneous flowers) were listed, and the realised functional diversity of each plot was calculated. Over the two years, an increase in functional diversity did not result in an increase in the abundance and richness of aphid predators. Moreover, ladybeetles, representing the majority of trapped predators, were more abundant in mixtures with very low or intermediary functional diversity at sowing, especially in 2014. We hypothesise that certain flower species, which were abundant in certain mixtures (and not in those exhibiting the highest functional diversity), attracted predators and were sufficiently represented to support them. Our results present novel information that could be used to the development of flower mixtures that provide effective ecosystem services, such as pest control. [less ▲]

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See detailSustainability and management control. Exploring and theorizing control patterns in large European firms
Crutzen, Nathalie ULg; Zvezdov, Dimitar; Schaltegger, Stefan

in Journal of Cleaner Production (2017), 143

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See detailA comparative study on optimum insulation thickness of walls and energy savings in equatorial and tropical climate
Kameni Nematchoua, Modeste; Ricciardi, Paola; Reiter, Sigrid ULg et al

in International Journal of Sustainable Built Environment (2017)

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well ... [more ▼]

The increase outdoor temperature acts directly on the indoor climate of buildings. In Cameroon, the energy consumption demand in the buildings sector has been rapidly increasing in recent years; so well that energy supply does not always satisfy demand. Thermal insulation technology can be one of the leading methods for reducing energy consumption in these new buildings. However, choosing the thickness of the insulation material often causes high insulation costs. In the present study, the optimum insulation thickness, energy saving and payback period were calculated for buildings in Yaounde´ and Garoua cities, located in two climatic regions in Cameroon. The economic model including the cost of insulation material and the present value of energy consumption and the cost over a life time of 22 years of the building, were used to find the optimum insulation thickness, energy saving, and payback period. Materials that extruded polystyrene were chosen and used for two typical wall structures (concrete block (HCB) and compressed stabilized earth block wall (CSEB)). The early cooling transmission loads, according to wall orientations and percentage of radiation blocked were calculated using the explicit finite-difference method under steady periodic conditions. As a result, it was found that the west- and east-facing walls are the least favourite in the cooling season, whereas the south and north orientations are the most economical. Although wall orientation had a significant effect on the optimum insulation thickness, it had a more significant effect on energy savings. In equatorial region (Yaounde´), for south orientation, the optimum insulation thickness was 0.08 m for an energy savings of 51.69 $/m2. Meanwhile, in tropical region (Garoua), for north orientation, the optimum insulation thickness was 0.11 m for an energy savings of 97.82 $/m2. [less ▲]

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See detailCXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone.
Goffart, Nicolas ULg; Lombard, Arnaud; Lallemand, François ULg et al

in Neuro-Oncology (2017), 19(1), 66-77

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that ... [more ▼]

BACKGROUND: Patients with glioblastoma (GBM) have an overall median survival of 15 months despite multimodal therapy. These catastrophic survival rates are to be correlated to systematic relapses that might arise from remaining glioblastoma stem cells (GSCs) left behind after surgery. In this line, it has recently been demonstrated that GSCs are able to escape the tumor mass and preferentially colonize the adult subventricular zone (SVZ). At a distance from the initial tumor site, these GSCs might therefore represent a high-quality model of clinical resilience to therapy and cancer relapses as they specifically retain tumor-initiating abilities. METHOD: While relying on recent findings that have validated the existence of GSCs in the human SVZ, we questioned the role of the SVZ niche as a potential GSC reservoir involved in therapeutic failure. RESULTS: Our results demonstrate that (i) GSCs located in the SVZ are specifically resistant to radiation in vivo, (ii) these cells display enhanced mesenchymal roots that are known to be associated with cancer radioresistance, (iii) these mesenchymal traits are specifically upregulated by CXCL12 (stromal cell-derived factor-1) both in vitro and in the SVZ environment, (iv) the amount of SVZ-released CXCL12 mediates GBM resistance to radiation in vitro, and (v) interferes with the CXCL12/CXCR4 signalling system, allowing weakening of the tumor mesenchymal roots and radiosensitizing SVZ-nested GBM cells. CONCLUSION: Together, these data provide evidence on how the adult SVZ environment, through the release of CXCL12, supports GBM therapeutic failure and potential tumor relapse. [less ▲]

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See detailFluctuations of Attentional Networks and Default Mode Network during the Resting State Reflect Variations in Cognitive States: Evidence from a Novel Resting-state
Van Calster, Laurens ULg; D'Argembeau, Arnaud ULg; SALMON, Eric ULg et al

in Journal of Cognitive Neuroscience (2017)

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's ... [more ▼]

Neuroimaging studies have revealed the recruitment of a range of neural networks during the resting state, which might reflect a variety of cognitive experiences and processes occurring in an individual's mind. In this study, we focused on the default mode network (DMN) and attentional networks and investigated their association with distinct mental states when participants are not performing an explicit task. To investigate the range of possible cognitive experiences more directly, this study proposes a novel method of resting-state fMRI experience sampling, informed by a phenomenological investigation of the fluctuation of mental states during the resting state. We hypothesized that DMN activity would increase as a function of internal mentation and that the activity of dorsal and ventral networks would indicate states of top–down versus bottom–up attention at rest. Results showed that dorsal attention network activity fluctuated as a function of subjective reports of attentional control, providing evidence that activity of this network reflects the perceived recruitment of controlled attentional processes during spontaneous cognition. Activity of the DMN increased when participants reported to be in a subjective state of internal mentation, but not when they reported to be in a state of perception. This study provides direct evidence for a link between fluctuations of resting-state neural activity and fluctuations in specific cognitive processes. [less ▲]

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See detailImpact of pollen resources drift on common bumblebees in NW Europe
Roger, N.; Moerman, R.; Carvalheiro, L. G. et al

in Global Change Biology (2017), 23(1), 68-76

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant ... [more ▼]

Several bee species are experiencing significant population declines. As bees exclusively rely on pollen for development and survival, such declines could be partly related to changes in their host plant abundance and quality. Here, we investigate whether generalist bumblebee species, with stable population trends over the past years, adapted their diets in response to changes in the distribution and chemical quality of their pollen resources. We selected five common species of bumblebee in NW Europe for which we had a precise description of their pollen diet through two time periods (‘prior to 1950’ and ‘2004–2005’). For each species, we assessed whether the shift in their pollen diet was related with the changes in the suitable area of their pollen resources. Concurrently, we evaluated whether the chemical composition of pollen resources changed over time and experimentally tested the impact of new major pollen species on the development of B. terrestris microcolonies. Only one species (i.e. B. lapidarius) significantly included more pollen from resources whose suitable area expanded. This opportunist pattern could partly explain the expansion of B. lapidarius in Europe. Regarding the temporal variation in the chemical composition of the pollen diet, total and essential amino acid contents did not differ significantly between the two time periods while we found significant differences among plant species. This result is driven by the great diversity of resources used by bumblebee species in both periods. Our bioassay revealed that the shift to new major pollen resources allowed microcolonies to develop, bringing new evidence on the opportunist feature of bumblebee in their diets. Overall, this study shows that the response to pollen resource drift varies among closely related pollinators, and a species-rich plant community ensures generalist species to select a nutrient-rich pollen diet. © 2016 John Wiley & Sons Ltd [less ▲]

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See detailModeling pre-metastatic lymphvascular niche in the mouse ear sponge assay.
Garcia-Caballero, Melissa; Van De Velde, Maureen ULg; Blacher, Silvia ULg et al

in Scientific Reports (2017), 7

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental ... [more ▼]

Lymphangiogenesis, the formation of new lymphatic vessels, occurs in primary tumors and in draining lymph nodes leading to pre-metastatic niche formation. Reliable in vivo models are becoming instrumental for investigating alterations occurring in lymph nodes before tumor cell arrival. In this study, we demonstrate that B16F10 melanoma cell encapsulation in a biomaterial, and implantation in the mouse ear, prevents their rapid lymphatic spread observed when cells are directly injected in the ear. Vascular remodeling in lymph nodes was detected two weeks after sponge implantation, while their colonization by tumor cells occurred two weeks later. In this model, a huge lymphangiogenic response was induced in primary tumors and in pre-metastatic and metastatic lymph nodes. In control lymph nodes, lymphatic vessels were confined to the cortex. In contrast, an enlargement and expansion of lymphatic vessels towards paracortical and medullar areas occurred in pre-metastatic lymph nodes. We designed an original computerized-assisted quantification method to examine the lymphatic vessel structure and the spatial distribution. This new reliable and accurate model is suitable for in vivo studies of lymphangiogenesis, holds promise for unraveling the mechanisms underlying lymphatic metastases and pre-metastatic niche formation in lymph nodes, and will provide new tools for drug testing. [less ▲]

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See detailCabergoline for Cushing's disease: a large retrospective multicenter study.
Ferriere, A.; Cortet, C.; Chanson, P. et al

in European Journal of Endocrinology (2017), 176(3), 305-314

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of ... [more ▼]

OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded. RESULTS: Twenty-one (40%) of 53 patients who received cabergoline monotherapy had normal urinary free cortisol (UFC) values within 12 months (complete responders), and five of these patients developed corticotropic insufficiency. The fall in UFC was associated with significant reductions in midnight cortisol and plasma ACTH, and with clinical improvement. Compared to other patients, complete responders had similar median baseline UFC (2.0 vs 2.5xULN) and plasma prolactin concentrations but received lower doses of cabergoline (1.5 vs 3.5 mg/week, P < 0.05). During long-term treatment (>12 months), cabergoline was withdrawn in 28% of complete responders because of treatment escape or intolerance. Overall, sustained control of hypercortisolism was obtained in 23% of patients for 32.5 months (19-105). Nine patients on steroidogenesis inhibitors received cabergoline add-on therapy for 19 months (1-240). Hypercortisolism was controlled in 56% of these patients during the first year of treatment with cabergoline at 1.0 mg/week (0.5-3.5). CONCLUSIONS: About 20-25% of CD patients are good responders to cabergoline therapy allowing long-term control of hypercortisolism at relatively low dosages and with acceptable tolerability. No single parameter, including the baseline UFC and prolactin levels, predicted the response to cabergoline. [less ▲]

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See detailIncreased expression of bacterial amoA during an N2O emission peak in an agricultural field
Theodorakopoulos, Nicolas ULg; Lognoul, Margaux ULg; Degrune, Florine ULg et al

in Agriculture, Ecosystems & Environment (2017), 236

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak ... [more ▼]

Levels of N-cycle gene transcripts (nirK, nirS, nosZ, amoA) were measured during an N2O emission peak in an agricultural soil. Automated dynamic closed chambers were used to monitor an N2O emission peak on a maize crop after a natural rainfall. The peak occurred rapidly after the rainfall began. Spatial and temporal variability in N2O emission was observed between chambers. An analysis of N-cycle gene transcript levels revealed an increase in bacterial amoA gene transcripts (but not in archaeal amoA transcripts), correlating strongly with N2O emission. This suggests the involvement of nitrification enzymes, despite a high water-filled pore space (80%). Reverse transcription of bacterial 16S rRNA followed by partial sequencing of the resulting cDNAs revealed few rainfall-induced changes in the potentially active bacterial community, and notably no significant change in the relative abundance of 16S rRNAs from the nitrifier genus Nitrosospira. Expression of the amoA gene appears as a possible proxy for monitoring the N2O emission peak. To our knowledge, this is the first experiment to evaluate the expression of N-cycle genes during an N2O emission peak on an agricultural field. [less ▲]

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See detailChemical Composition and Acaricidal Activity of Thymus algeriensis Essential Oil against Varroa destructor
Kouache, Benmoussa; Brada, Moussa; Saadi, Abdelkader et al

in Natural Product Communications (2017), 12(0), 1-4

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is ... [more ▼]

The aim of the present study was to determine the chemical composition and evaluate the acaricidal activity of Thymus algeriensis essential oil (TAEO) against Varroa destructor. This ectoparasitic mite is a pest of the honey bee Apis mellifera. The essential oil from the aerial parts of T. algeriensis, obtained by hydrodistillation, was obtained in a yield of 2.8± 0.2%, w/w. The TAEO was analyzed by GC and GC/MS. Thirty-four compounds were identified, representing 99.3% of the oil. The main constituents were carvacrol (48.4%), γ-terpinene (14.9%), p-cymene (14.7%), and thymol (5.6%). Four lots were constituted at the level of an apiary in order to study the dynamics of the Varroa destructor and its host, Apis mellifera. After diagnosis by the biological method "install of diapers", the lots were treated at different doses of TAEO (0.1, 0.3 and 0.5%). TAEO was sprayed on top of the hives. The results show that TAEO at 0.5% resulted in a decrease in the rate of infestation of Varroa destructor, causing a mortality rate of 32.6% without negative effect on the nesting of the queen. The essential oil of T. algeriensis could be used as a bioacaricidal agent. [less ▲]

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See detailPreterm Infant Growth Velocity Calculations: A Systematic Review
Fenton, Tanis; Chan, Hilton; Madhu, Aiswarya et al

in Pediatrics (2017), 139(3), 1-10

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See detailInstitutional pedagogy for an autonomous society: Castoriadis & Lapassade
Wustefeld, Sophie ULg

in Educational Philosophy & Theory (2017)

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See detailAdresse, opinion et responsabilité : un modèle de la subjectivation en public
Servais, Christine ULg

in Questions de Communication (2017)

Cet article interroge la relation entre « publics » et « collectifs » et en propose un modèle de description à caractère phénoménologique. Après un examen des implications politiques des modèles auxquels ... [more ▼]

Cet article interroge la relation entre « publics » et « collectifs » et en propose un modèle de description à caractère phénoménologique. Après un examen des implications politiques des modèles auxquels sont susceptibles de se référer les théories de la réception médiatique, on tente d’élaborer, à partir du travail de Stiegler, de Rancière et de Derrida, une approche de la réception qui permet de décrire à la fois l’émancipation et la domination, cette alternative étant l’un des points de butée des théories de la réception. Le critère déterminant est ici l’adresse, considérée comme la traduction en termes phénoménologiques de l’énonciation. La réception est alors envisagée comme une réponse à une adresse. Cette conception de l’énonciation rend compte de la dimension politique d’une réception médiatique où l’identité sociale est désormais indexée sur notre identité de destinataires de dispositifs médiatique, c’est-à-dire de publics [less ▲]

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See detailRegeneration after fire in campo rupestre: Short- and long-term vegetation dynamics
Le Stradic, Soizig ULg; Hernandez, P.; Fernandes, G. W. et al

in Flora: Morphology, Distribution, Functional Ecology of Plants (2017)

The Cerrado (Brazilian savanna) is the second largest biome in Brazil, covering 22% of the country, and campo rupestre is one of the most biodiverse ecosystem. Campo rupestre are extremely old mountaintop ... [more ▼]

The Cerrado (Brazilian savanna) is the second largest biome in Brazil, covering 22% of the country, and campo rupestre is one of the most biodiverse ecosystem. Campo rupestre are extremely old mountaintop tropical ecosystems, composed of a mosaic of herbaceous, shrubland and savanna vegetation, generally located above 900. m above sea level characterized by shallow, acidic and nutrient-poor soils. In the context of increased land-use changes, effective conservation and management projects appear necessary to guarantee the conservation of these ecosystems. Although fire is a natural disturbance in campo rupestre, the effects of fire on vegetation dynamics remain poorly understood. Our objective was to assess the effects of fire on vegetation recovery and plant composition on both the short- and long-term in the main herbaceous vegetation types: the sandy and stony grasslands. We monitored plant community composition before and after a wildfire in order to assess the short-term vegetation recovery. Diachronic analyses of grasslands burnt at various dates were used to understand the effects of fire on the long-term vegetation dynamics. Our results highlighted a rapid recovery of campo rupestre vegetation after wildfires, suggesting a high adaptation to fire of plant communities. We did not find a significant variation in species richness of sandy grasslands according to time after fire, whereas higher species richness was observed in the recently burnt stony grasslands. No change in plant composition of campo rupestre in response to fire was highlighted, probably due to the high heterogeneity of this ecosystem. After fire, biomass gradually increased over time in both vegetation types. High biomass accumulation could lead to stronger fires. Further studies are necessary to understand the relationship between biomass accumulation and fire intensity in campo rupestre in order to set up adapted fire management strategies to conserve campo rupestre biodiversity. © 2017 Elsevier GmbH. [less ▲]

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See detailCOMPUTATIONAL METHODS IN MANUFACTURING
Ponthot, Jean-Philippe ULg; Feulvarch, Eric; Drapier, Sylvain et al

in International Journal of Material Forming (2017), 10

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See detailEvaluation of the long-term effect of biochar on properties of temperate agricultural soil at pre-industrial charcoal kiln sites in Wallonia, Belgium
Hardy, Brieuc; Cornelis, Jean-Thomas ULg; Houben, David et al

in European Journal of Soil Science (2017), 68

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See detailThree-Dimensional Morphology of the Left Ventricular Outflow Tract: Impact on Grading Aortic Stenosis Severity.
Caballero, Luis; Saura, Daniel; Oliva-Sandoval, Maria Jose et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2017), 30(1), 28-35

BACKGROUND: Left ventricular outflow tract (LVOT) measurement is a critical step in the quantification of aortic valve area. The assumption of a circular morphology of the LVOT may induce some errors. The ... [more ▼]

BACKGROUND: Left ventricular outflow tract (LVOT) measurement is a critical step in the quantification of aortic valve area. The assumption of a circular morphology of the LVOT may induce some errors. The aim of this study was to assess the three-dimensional (3D) morphology of the LVOT and its impact on grading aortic stenosis severity. METHODS: Fifty-eight patients with aortic stenosis were studied retrospectively. LVOT dimensions were measured using 3D transesophageal echocardiography at three levels: at the hinge points (HP) of the aortic valve and at 4 and 8 mm proximal to the annular plane. Results were compared with standard two-dimensional echocardiographic measurements. RESULTS: Three-dimensional transesophageal echocardiography showed a funnel shape that was more circular at the HP and more elliptical at 4 and 8 mm proximal to the annular plane (circularity index = 0.92 vs 0.83 vs 0.76, P < .001). Cross-sectional area was smaller at the HP and larger at 4 and 8 mm from the annular plane (3.6 vs 3.9 vs 4.1 cm2, P = .001). The best correlation between two-dimensional and 3D transesophageal echocardiographic dimensions was at the HP (intraclass correlation coefficient = 0.75; 95% CI, 0.59-0.86). When the HP approach was selected, there was a reduction in the percentage of patients with low flow (from 41% to 29%). CONCLUSIONS: A large portion of patients with aortic stenosis have funnel-shaped and elliptical LVOTs, a morphology that is more pronounced in the region farther from the annular plane. Two-dimensional LVOT measurement closer to the annular plane has the best correlation with 3D measurements. Measurement of the LVOT closer to the annular plane should be encouraged to reduce measurement errors. [less ▲]

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See detailAn Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters
Delcourt, Cécile ULg; Gremler, Dwayne; De Zanet, Fabrice ULg et al

in Journal of Service Management (2017), 28(1), 85-106

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them ... [more ▼]

Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative customer emotions and customer satisfaction with employee response in ECSEs. Design/methodology—This study relies on a video-based experiment that depicts a customer involved in an ECSE as a service provider delivers bad news to him. The hypothesis tests use a two-way independent analysis of covariance. Results—Both emotional and technical competencies must be displayed to improve the customer experience in an ECSE. When EEC is low, ETC does not decrease negative customer emotions or increase customer satisfaction with employee response. When EEC is high, ETC instead has a significant impact on both customer outcomes. Practical implications—Managers must train employees to develop both technical and emotional competencies. Employees who demonstrate only one type cannot temper customers’ emotions or enhance their perceptions of the employees’ response as well as can those strong in both competencies. Originality/value—Using a video-based experiment, this study examines the moderating role of EEC in the relationship between ETC and two key aspects of the customer experience in an ECSE (negative customer emotions and customer satisfaction with employee responses) following the delivery of bad news. [less ▲]

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See detailSpaces Snu, diametral dimension and property Omega bar
Demeulenaere, Loïc ULg

in Journal of Mathematical Analysis and Applications (2017), 449(2), 1340-1350

This paper investigates two topological invariants in the context of the sequence spaces Snu, which are metric topological vector spaces defined in order to study the regularity of signals. First, it ... [more ▼]

This paper investigates two topological invariants in the context of the sequence spaces Snu, which are metric topological vector spaces defined in order to study the regularity of signals. First, it extends the formula already known of the diametral dimension of spaces Snu to some non-locally pseudoconvex ones. Second, it proves that locally p-convex spaces Snu verifies the property "Omega id", which is equivalent to Omega bar for Fréchet spaces. [less ▲]

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See detailDeciphering the factors defining the pH-dependence of a commercial glycoside hydrolase family 8 enzyme
Barroca, M.; Santos, G.; Johansson, B. et al

in Enzyme and Microbial Technology (2017), 96

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See detailLa « personnalité antisociale », antithèse de la psychopathologie
Englebert, Jérôme ULg; Adam, Christophe

in Déviance et Société (2017), 41(1), 3-28

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au ... [more ▼]

L’article propose une réflexion critique et clinique sur la notion de « personnalité antisociale », largement usitée dans le domaine de la nosographie des troubles mentaux et des pratiques « psy- » au sein du système de justice pénale. Notre réflexion débutera par une généalogie du vocable dans différentes versions de la classification psychiatrique, depuis les années cinquante jusqu’aujourd’hui, et plus particulièrement celle faisant autorité du Manuel statistique et diagnostique des troubles mentaux (DSM). L’absence de raisonnement sociologique dans l’usage d’une notion impliquant pourtant la référence au « social » sera discutée ainsi que ses évolutions historiques. Ensuite, la démonstration de l’antithèse que cette notion constitue pour une perspective psychopathologique digne de ce nom – dynamique, compréhensive et phénoménologique – sera développée en six arguments majeurs et plurivoques, tantôt empiriques et cliniques, tantôt théoriques. [less ▲]

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