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See detailVirtual Issue celebrating the 100th volume of the Journal of Animal Physiology and Animal Nutrition
Fascetti, A. J.; Everaert, Nadia ULg

in Journal of Animal Physiology and Animal Nutrition (2016), 100(1), 1-2

[No abstract available]

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See detailInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al

in Lancet (2016)

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See detailUnveiling Network and Service Performance Degradation in the Wild with mPlane
Casas, Pedro; Fiadino, Pierdomenico; Wassermann, Sarah ULg et al

in IEEE Communications Magazine - Network Testing Series (2016)

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity ... [more ▼]

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity. However, its distributed nature leads to operational brittleness and difficulty in identifying the root causes of performance degradation. In such a context, network measurements are a fundamental pillar to shed light and to unveil design and implementation defects. To tackle this fragmentation and visibility problem, we have recently conceived mPlane, a distributed measurement platform which runs, collects and analyses traffic measurements to study the operation and functioning of the Internet. In this paper, we show the potentiality of the mPlane approach to unveil network and service degradation issues in live, operational networks, involving both fixed-line and cellular networks. In particular, we combine active and passive measurements to troubleshoot problems in end-customer Internet access connections, or to automatically detect and diagnose anomalies in Internet-scale services (e.g., YouTube) which impact a large number of end-users. [less ▲]

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See detailThe Medium is the Message. Olivier Schrauwen's ‘Arsène Schrauwen’ Beyond Expectations of Autobiography, Colonial History and the Graphic Novel
Crucifix, Benoît ULg; Meesters, Gert

in European Comic Art (2016), 9(1),

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the ... [more ▼]

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the field of comics. First of all, Schrauwen playfully questions the entrenchment of autobiography in the contemporary graphic novel by presenting a wholly fantasized adventure as biographical family history. This play with generic expectations is continued through Schrauwen’s reliance on the tropes of the adventure story and its figuration of the voyage. Arsène Schrauwen also draws on stereotypical images of both Belgium and the Belgian Congo and integrates them into a grotesque narrative so as to question the supposed unicity of the individual and colonial bodies. Last but not least, the book displays a highly self-reflexive approach to comics storytelling, building on a legacy from Flemish comics in order to play with reading conventions, graphic enunciation and abstraction, thereby thematising the perception of the main character. [less ▲]

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See detailContinuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Di Marco, Lorenzo; Hans, Morgan; Delaude, Lionel ULg et al

in Chemistry : A European Journal (2016)

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a ... [more ▼]

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homoge¬neous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions, namely, the transesterification of vinyl acetate with benzyl alcohol and the amidation of N-Boc-glycine methyl ester with ethanolamine. Both organocatalytic transfor¬ma¬tions proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs. [less ▲]

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See detailCompte-rendu de l'ouvrage Cluny. Les moines et la société au premier age féodal
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailDe la perversion au pervers ; du sexuel à l’adaptatif
Englebert, Jérôme ULg

in Psychosomatique Relationnelle (2016), 5(1),

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See detailDes situations-limites au dépassement de la situation : phénoménologie d'un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

in Sartre Studies International (2016), 22(1),

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant ... [more ▼]

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant. Notre approche se fonde sur un double mouvement : d’une part, une archéologie du concept dans le contexte de la première percée de la phénoménologie en France dans les années 1930 ; d’autre part, une attention à son possible dépassement deux décennies plus tard. Dans une relation serrée avec les développements de la psychopathologie de son temps, il s’agit d’abord de situer la prétention de l’Esquisse d’une théorie des émotions à poser les bases d’une phénoménologie de « l’homme en situation », ensuite d’éclairer la reprise critique du concept dans Questions de méthode, dans l’exposition de la méthode progressive-régressive. En somme, il s’agit de montrer comment s’élabore progressivement chez Sartre une « herméneutique de l’existence » qui fait droit à la liberté, puis se donne les moyens d’en suivre l’action effective dans le monde. [less ▲]

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See detailPhysical, functional and structural characterization of the cell wall fractions from baker's yeast Saccharomyces cerevisiae
Borchani, C.; Fonteyn, F.; Jamin, G. et al

in Food Chemistry (2016), 194

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast ... [more ▼]

The yeast cell wall of Saccharomyces cerevisiae is an important source of β-D-glucan, a glucose homopolymer with many functional, nutritional and human health benefits. In the present study, the yeast cell wall fractionation process involving enzymatic treatments (savinase and lipolase enzymes) affected most of the physical and functional characteristics of extracted fractions. Thus, the fractionation process showed that β-D-glucan fraction F4 had significantly higher swelling power and fat binding capacity compared to other fractions (F1, F2 and F3). It also exhibited a viscosity of 652.12 mPa s and a high degree of brightness of extracted β-D-glucan fraction. Moreover, the fractionation process seemed to have an effect on structural and thermal properties of extracted fractions. Overall, results showed that yeast β-D-glucan had good potential for use as a prebiotic ingredient in food, as well as medicinal and pharmaceutical products. © 2015, Elsevier Ltd. All rights reserved. [less ▲]

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See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2),

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

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See detailPhenolic profile, antibacterial and cytotoxic properties of second grade date extract from Tunisian cultivars (Phoenix dactylifera L.)
Kchaou, Wissal; Abbès, Fatma; Ben Mansour, Riadh et al

in Food Chemistry (2016), (194), 1048-1055

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic ... [more ▼]

The present study aimed to investigate the phenolic profile of second grade date extracts and evaluate their antimicrobial and cytotoxic activities with regard to some pathogenic microorganisms. Phenolic content was analyzed by HPLC. Antimicrobial activity was evaluated by the agar disk diffusion method, and in vitro cytotoxic activity was examined by cell proliferation assay. The results revealed that second grade dates presented three benzoic acids, five cinnamic acids and two flavonoids, with the predominance of q-coumaric acid (1998.80 lg/100 g). The antimicrobial activities showed that the date extracts were active against Gram (+) and Gram (-) bacteria, showing marked activity against Escherichia coli with an inhibition zone of 25 mm. Cytotoxicity assays showed that the date extracts were able to inhibit the proliferation of HeLa cell lines. The results confirmed that the date extracts were rich in biologically active compounds that are highly valued in the functional food and nutraceutical industries. [less ▲]

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailCapitalizing in fine milk composition for breeding and management of dairy cows
Gengler, Nicolas ULg; Soyeurt, Hélène ULg; Dehareng, Fréderic et al

in Journal of Dairy Science (2016), 99

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of ... [more ▼]

The challenge of managing and breeding dairy cows is permanently adapting to changing production circumstances under socio-economic constraints. If managing and breeding address different timeframes of action, both need relevant phenotypes that allow for precise monitoring of the status of the cows, and their health, behavior, and well-being as well as their environmental impact and the quality of their products (i.e., milk and subsequently dairy products). Milk composition has been identified as an important source of information because it could reflect, at least partially, all these elements. Major conventional milk components such as fat, protein, urea, and lactose contents are routinely predicted by mid-infrared (MIR) spectrometry and have been widely used for these purposes. But, milk composition is much more complex and other nonconventional milk components, potentially predicted by MIR, might be informative. Such new milk-based phenotypes should be considered given that they are cheap, rapidly obtained, usable on a large scale, robust, and reliable. In a first approach, new phenotypes can be predicted from MIR spectra using techniques based on classical prediction equations. This method was used successfully for many novel traits (e.g., fatty acids, lactoferrin, minerals, milk technological properties, citrate) that can be then useful for management and breeding purposes. An innovation was to consider the longitudinal nature of the relationship between the trait of interest and the MIR spectra (e.g., to predict methane from MIR). By avoiding intermediate steps, prediction errors can be minimized when traits of interest (e.g., methane, energy balance, ketosis) are predicted directly from MIR spectra. In a second approach, research is ongoing to detect and exploit patterns in an innovative manner, by comparing observed with expected MIR spectra directly (e.g., pregnancy). All of these traits can then be used to define best practices, adjust feeding and health management, improve animal welfare, improve milk quality, and mitigate environmental impact. Under the condition that MIR data are available on a large scale, phenotypes for these traits will allow genetic and genomic evaluations. Introduction of novel traits into the breeding objectives will need additional research to clarify socio-economic weights and genetic correlations with other traits of interest. [less ▲]

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See detailTreacher Collins syndrome: a clinical and molecular study based on a large series of patients.
Vincent, Marie; Genevieve, David; Ostertag, Agnes et al

in Genetics in medicine : official journal of the American College of Medical Genetics (2016), 18(1), 49-56

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically ... [more ▼]

PURPOSE: Treacher Collins/Franceschetti syndrome (TCS; OMIM 154500) is a disorder of craniofacial development belonging to the heterogeneous group of mandibulofacial dysostoses. TCS is classically characterized by bilateral mandibular and malar hypoplasia, downward-slanting palpebral fissures, and microtia. To date, three genes have been identified in TCS:,TCOF1, POLR1D, and POLR1C. METHODS: We report a clinical and extensive molecular study, including TCOF1, POLR1D, POLR1C, and EFTUD2 genes, in a series of 146 patients with TCS. Phenotype-genotype correlations were investigated for 19 clinical features, between TCOF1 and POLR1D, and the type of mutation or its localization in the TCOF1 gene. RESULTS: We identified 92/146 patients (63%) with a molecular anomaly within TCOF1, 9/146 (6%) within POLR1D, and none within POLR1C. Among the atypical negative patients (with intellectual disability and/or microcephaly), we identified four patients carrying a mutation in EFTUD2 and two patients with 5q32 deletion encompassing TCOF1 and CAMK2A in particular. Congenital cardiac defects occurred more frequently among patients with TCOF1 mutation (7/92, 8%) than reported in the literature. CONCLUSION: Even though TCOF1 and POLR1D were associated with extreme clinical variability, we found no phenotype-genotype correlation. In cases with a typical phenotype of TCS, 6/146 (4%) remained with an unidentified molecular defect.Genet Med 18 1, 49-56. [less ▲]

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See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

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See detailTypus melancholicus et mélancolie : Synthèse théorique à partir d’un cas clinique
Englebert, Jérôme ULg; Stanghellini, Giovanni

in Encéphale (L') (2016), 42(1), 105-111

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to ... [more ▼]

Objective: The objective of this paper is to propose, starting from the description of a clinical emblematic case, a theoretical synthesis of the work of phenomenological psychopathology dedicated to melancholia and typus melancholicus (TM), a clinical concept that describes the premorbid personality vulnerable to major depression (“melancholia” for the psychopathological tradition). Method: This is phenomenological analysis of a case study of melancolia, of its premorbid personality and pathogenic triggering situation. We adopt two main phenomenological keys to understanding the develpment of melancholia : role-identity theory and desynchronization theory. The former understands melancholia as a disorder of identity triggered by the loss of the social role with which one has previously over-identifed. The latter sees melancholia as the effect of the desynchronisation from the social environment that further develops into an inhibition of the conative–affective dynamics of life. We present the case of Jonas (64 years old), whose mother (94 years old) recently died. Before his mother’s death, Jonas’ life was entirely orchestrated by the caring for his mother and synchronized in time with this (e.g., he used to go to her house every 4 hours, took all his meals with her, etc.). Jonas, in addition to being hyper-synchronized and hyper-syntonic, fulfills all diagnostic criteria for TM, including “orderliness”, “conscientiousness”, “hyper/heteronomia” and “intolerance of ambiguity”. TM’s attach a disproportioned importance to their social roles (or external representations of identity) at the expense of their own ego-identity. Results: The passage from pre-morbid personality to melancholia is triggered by the death of Jonas’ mother that entails a profound depersonalization. Desynchronization and role loss cause Jonas fall into this severe depersonalization, whose core feature is the feeling of the loss of feeling. Conclusions: This original contribution demonstrates a clinical case can contribute to the construction and refinement of theoretical and conceptual frameworks (like princeps Tellenbach's studies). Over-synchronized tempo and over-identification with social role are emblematically in this case the two sides of the same coin. A parallelism can be established between synchronization (with the mother) and respect for the role at the expense of own identity. The clinical case of Jonas highlights a conceptual bridge between the model of melancholia as loss of social role and the model of melancholia as desynchronization. [less ▲]

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See detailMagnetic flux penetration in Nb superconducting films with lithographically defined micro-indentations
Brisbois, Jérémy ULg; Adami, Obaïd-Allah ULg; Avila Osses, Jonathan ULg et al

in Physical Review B (2016)

We present a thorough investigation by magneto-optical imaging of the magnetic flux penetration in Nb thin films with lithographically defined border indentations. We demonstrate that discontinuity lines ... [more ▼]

We present a thorough investigation by magneto-optical imaging of the magnetic flux penetration in Nb thin films with lithographically defined border indentations. We demonstrate that discontinuity lines (d-lines), caused by the abrupt bending of current streamlines around the indentations, depart from the expected parabolic trend close to the defect and depend on the shape and size of the indentation as well as on the temperature. These findings are backed up and compared with theoretical results obtained by numerical simulations and analytical calculations highlighting the key role played by demagnetization effects and the creep exponent n. In addition, we show that the presence of nearby indentations and submicrometer random roughness of the sample border can severely modify the flux front topology and dynamics. Strikingly, in contrast to what has been repeatedly predicted in the literature, we do not observe that indentations act as nucleation spots for flux avalanches, but they instead help to release the flux pressure and avoid thermomagnetic instabilities. [less ▲]

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See detailMethods of ex vivo expansion of human cord blood cells: challenges, successes and clinical implications
Baron, Frédéric ULg; Ruggeri, A.; Nagler, A.

in Expert Review of Hematology (2016), 21

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low ... [more ▼]

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low absolute numbers of hematopoietic stem and progenitor cells (HSPCs) within a single cord blood unit has remained a limiting factor for this transplantation modality, particularly in adult recipients. Further, because UCB contains low numbers of mostly naïve T cells, immune recovery after UCBT is slow predisposing patients to severe infections. Other causes of UCBT failure has included graft-versus-host disease (GVHD), and relapse of the underlying disease. In this article, we first review the current landscape of cord blood engineering aimed at improving engraftment. This includes approaches of UCB-HSPCs expansion and methods aimed at improving UCB-HSCPs homing. We then discuss recent approaches of cord blood engineering developed to prevent infection (generation of multivirus-specific cytotoxic T cells (VSTs) from UCB), relapse (transduction of UCB-T cells with tumor-specific chimeric receptor antigens (CARs)) and GVHD (expansion of regulatory T cells from UCB). Although many of these techniques of UCB engineering remain currently technically challenging and expensive, they are likely to revolutionize the field of UCBT in the next decades. [less ▲]

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See detailDSIMA: A testbed for the quantitative analysis of interaction models within distribution networks
Mathieu, Sébastien ULg; Louveaux, Quentin ULg; Ernst, Damien ULg et al

in Sustainable Energy, Grids and Networks (2016), 5

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in ... [more ▼]

This article proposes an open-source testbed to simulate interaction models governing the exchange of flexibility services located within a distribution network. The testbed is an agent-based system in which the distribution system operator, the transmission system operator, producers and retailers make their decisions based on mixed-integer linear programs. This testbed helps to highlight the characteristics of an interaction model, the benefits for the agents and eases the detection of unwanted or abusive behaviors which decreases the welfare. The testbed is implemented in Python and the optimization problems are encoded in the modeling language ZIMPL. A web interface is coupled with an instance generator using macroscopic parameters of the system such as the total power production. This testbed is, therefore, well suited to test the implemented interaction models on various scenarios and to extend the implementation to other models. Five interaction models developed with industrial partners are simulated over a year on a 75-bus test system. Simulations show that interaction models relying on active network management, as they have been developed, lead to substantial welfare even though they suffer from a lack of coordination between the DSO and the TSO. A conservative interaction model restricting grid users to an access range that is computed ahead of time to prevent any congestion, avoids shedding distributed generation but considerably restrains the amount of distributed production. [less ▲]

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See detailShort term impact of selective logging on a western lowland gorilla population
Haurez, Barbara ULg; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Forest Ecology & Management (2016), 364

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services ... [more ▼]

Selective timber production is implemented over a large proportion of the world’s tropical forests. Within these forest ecosystems, the frugivore community contributes important ecological services through animal-mediated seed dispersal. However, there is no clear understanding of the impacts of logging on wildlife or of the extent to which seed dispersal is preserved in logged forests. Given its tendency for nesting in light gaps, the western lowland gorilla is likely to provide directed-dispersal services to a wide range of tree species. Production forests preserved from poaching have been reported to harbor high densities of gorillas, but the monitoring of gorilla populations subjected to logging is poorly documented. This study investigated gorilla density and nesting behavior after timber exploitation in a logging concession in southeast Gabon. Nest count censuses were performed on line transects, before and after the second felling cycle. Gorilla density dropped from 1.5 (116.7 nests km 2, 95% CI = 83.4–163.5) to 1.0 (64.9 nests km 2, % CI = 32.6–129.5) weaned gorilla km 2 4–6 months after logging, then rose to 2.6 (176.3 nests km 2, 95% CI = 113.5–274.1) gorillas km 2 9–11 months after logging. A consistent preference for nesting in open canopy terra firma forest was observed during all censuses. This study demonstrates the short-term resilience of the western lowland gorilla to selective timber harvesting, and argues that they offer a continued contribution to directed-dispersal services within months after logging. Although a long-term monitoring of gorillas in a logged forest should be undertaken, the role of this species in logged forest recovery is thought to be important. The preservation of gorilla should receive particular consideration by forest managers. [less ▲]

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See detailCompte rendu, La mise en scène des produits et des marques. Représentations,significations, publics
Duchesne, Caroline ULg

in Questions de Communication (2016), 28

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps ... [more ▼]

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps, l’évolution stratégique de la mise en scène des marques, la place symbolique occupée par celles-ci dans l’espace social et l’interpénétration grandissante des registres commerciaux et culturels présidant à leur positionnement stratégique. [less ▲]

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See detailLes croyances délétères des patients lombalgiques : revue narrative de la littérature
Demoulin, Christophe ULg; Roussel, Nathalie; Marty, Marc et al

in Revue Médicale de Liège (2016), 71(1), 40-46

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See detailThe development of the abilities to acquire novel detailed orthographic representations and maintain them in long-term memory
Binamé, Florence ULg; Poncelet, Martine ULg

in Journal of Experimental Child Psychology (2016), 143

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained ... [more ▼]

Previous studies have clearly demonstrated that the development of orthographic representations relies on phonological recoding. However, substantial questions persist about the remaining unexplained variance in the acquisition of word-specific orthographic knowledge that is still underspecified. The main aim of this study was to explore whether two cognitive factors—sensitivity to orthographic regularities and short-term memory (STM) for serial order—make independent contributions to the acquisition of novel orthographic representations beyond that of the phonological core component and the level of preexisting word-specific orthographic knowledge. To this end, we had children from second to sixth grades learn novel written word forms using a repeated spelling practice paradigm. The speed at which children learned the word forms and their long-term retention (1 week and 1 month later) were assessed. Hierarchical regression analyses revealed that phonological recoding, preexisting word-specific orthographic knowledge, and order STM explained a portion of the variance in orthographic learning speed, whereas phonological recoding, preexisting word-specific orthographic knowledge, and orthographic sensitivity each explained a portion of variance in the long-term retention of the newly created orthographic representations. A secondary aim of the study was to determine the developmental trajectory of the abilities to acquire novel orthographic word forms over the course of primary schooling. As expected, results showedan effect of age on both learning speed and long-term retention. The specific roles of orthographic sensitivity and order STM as independent factors involved in different steps of orthographic learning are discussed. [less ▲]

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See detailAirewater interfacial properties of enzymatic wheat gluten hydrolyzates determine their foaming behavior
Wouters, Arno G.B.; Rombouts, Ine; Legein, Marie et al

in Food Hydrocolloids (2016), 55

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different ... [more ▼]

Insight in the link between foaming and interfacial properties of proteins can increase their potential as functional agents in food systems. Here, foaming capacity and stability of structurally different peptic and tryptic wheat gluten hydrolyzates were related to the kinetics of their adsorption at an airewater interface as well as to the properties of a compressed protein film at this interface. Foams from degree of hydrolysis (DH, i.e. the percentage of cleaved peptide bonds) 2 hydrolyzates were more stable than those from their DH 6 counterparts, and this at all protein concentrations tested. However, at protein concentrations from 0.010% to 0.050% (wprot/v), peptic DH 2 and 6 hydrolyzates had better foaming stability than their tryptic counterparts of the same DH. The opposite was observed when protein concentrations ranged from 0.050% to 0.150% (wprot/v). These observations can in part be explained by the molecular mass composition of the samples and, more importantly, by high levels of hydrophobic peptides in the DH 2 samples. The calculation of an average elasticity (up to 20e25 mN/m) from the variation in surface pressure for a variation in surface area in Langmuir isotherms showed that DH 2 samples had higher elasticity than DH 6 samples, which was in agreement with their foaming stabilities at various protein concentrations. Additionally, although not usually considered in literature, it seemed there was a correspondence between surface pressure at different protein surface concentrations and foaming stability at different protein concentrations. [less ▲]

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See detailClassification of riparian forest species and health condition using multi-temporal and hyperspatial imagery from unmanned aerial system
Michez, Adrien ULg; Piégay, Hervé; Lisein, Jonathan ULg et al

in Environmental Monitoring and Assessment (2016), 188(3),

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring ... [more ▼]

Riparian forests are critically endangered many anthropogenic pressures and natural hazards. The importance of riparian zones has been acknowledged by European Directives, involving multi-scale monitoring. The use of this very high resolution and hyperspatial imagery in a multi-temporal approach is an emerging topic. The trend is reinforced by the recent and rapid growth of the use of the unmanned aerial system (UAS), which has prompted the development of innovative methodology. Our study proposes a methodological framework to explore how a set of multi-temporal images acquired during a vegetative period can differentiate some of the deciduous riparian forest species and their health conditions. More specifically, the developed approach intends to identify, through a process of variable selection, which variables derived from UAS imagery and which scale of image analysis are the most relevant to our objectives. The methodological framework is applied to two study sites to describe the riparian forest through two fundamental characteristics: the species composition and the health condition. These characteristics were selected not only because of their use as proxies for the riparian zone ecological integrity but also because of their use for river management. The comparison of various scales of image analysis identified the smallest OBIA objects (ca. 1 m²) as the most relevant scale. Variables derived from spectral information (bands ratio's) were identified as the most appropriate, followed by variables related to the vertical structure of the forest. Classification results show good overall accuracies for the species composition of the riparian forest (five classes, 79.5 and 84.1 % for Site 1 and Site 2). The classification scenario regarding the health condition of the black alders of the Site 1 performed the best (90.6 %). The quality of the classification models developed with a UAS-based, cost-effective, and semi-automatic approach competes successfully with those developed using more expensive imagery, such as multispectral and hyperspectral airborne imagery. The high overall accuracy results obtained by the classification of the diseased alders open the door to applications dedicated to monitoring of the health conditions of riparian forest. Our methodological framework will allow UAS users to manage large imagery metrics datasets derived from those dense time series. [less ▲]

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See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

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See detailUn moment machiavélien dans la théorie. Sur Althusser
Oulc'hen, Hervé ULg

in Cahiers du GRM (2015), 8

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See detailLe couplage « Micro-crédit, Micro-assurance santé et Offre des soins » peut améliorer l’accessibilité aux soins de santé de qualité en milieu urbain africain : Résultats d’une expérience menée dans la zone de santé de Bandalungwa à Kinshasa, Congo.
Manzambi Kuwekita, Joseph ULg; Gosset, Christiane ULg; Guillaume, Michèle ULg et al

in Médecine et Santé Tropicales (2015), 25

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in ... [more ▼]

Summary This study, based on a survey carried out in 2008, examines how coupling «microcredit, micro-insurance and health care» can improve access to quality care in the health zone of Bandalungwa, in Kinshasa. The bivariate analysis shows a significant association between the increase in purchasing power and realization of benefit (p = 0, 001), achievement of benefit and savings (p = 0, 000) savings and insurance health and improved access to health care: according to the main results, 68.8 %t of borrowers reported an increase in their purchasing power which 81.8% making benefit. Those with savings were 24.7 times more likely to contribute to a health insurance scheme than those without; 71.9% of those who have regularly contributed to health insurance have improved their access to care. Coupling microcredit, health microinsurance and health care can improve access to quality health care at lower cost. This suggests the integration of health insurance in the primary health care system. [less ▲]

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See detailRecommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia
Reginster, Jean-Yves ULg; Cooper, Cyrus; Rizzoli, René et al

in Aging Clinical and Experimental Research (2015)

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a ... [more ▼]

Purpose: Sarcopenia is an age-related muscle condition which is frequently a precursor of frailty, mobility disability and premature death. It has a high prevalence in older populations and presents a considerable social and economic burden. Potential treatments are under development but, as yet, no guidelines support regulatory studies for new drugs to manage sarcopenia. The objective of this position paper is therefore to suggest a set of potential endpoints and target population definitions to stimulate debate and progress within the medico-scientific and regulatory communities. Methods: A multidisciplinary expert working group was hosted by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, which reviewed and discussed the recent literature from a perspective of clinical experience and guideline development. Relevant parallels were drawn from the development of definition of osteoporosis as a disease and clinical assessment of pharmaceutical treatments for that indication. Results A case-finding decision tree is briefly reviewed with a discussion of recent prevalence estimations of different relevant threshold values. The selection criteria for patients in regulatory studies are discussed according to the aims of the investigation (sarcopenia prevention or treatment) and the stage of project development. The possible endpoints of such studies are reviewed and a pleais made for the establishment of a core outcome set to be used in all clinical trials of sarcopenia. Conclusions : The current lack of guidelines for the assessment of new therapeutic treatments for sarcopenia could potentially hinder the delivery of effective medicines to patients at risk. [less ▲]

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See detailLe droit constitutionnel de la Principauté de Liège au 18e siècle
Behrendt, Christian ULg; Vandenbosch, Sofia ULg

in Revue Belge de Droit Constitutionnel [= RBDC] (2015), 2015

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See detailCirculating microRNA-based screening tool for breast cancer
Freres, Pierre ULg; Wenric, Stéphane ULg; Boukerroucha, Meriem et al

in Oncotarget (2015)

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative ... [more ▼]

Circulating microRNAs (miRNAs) are increasingly recognized as powerful biomarkers in several pathologies, including breast cancer. Here, their plasmatic levels were measured to be used as an alternative screening procedure to mammography for breast cancer diagnosis. A plasma miRNA profile was determined by RT-qPCR in a cohort of 378 women. A diagnostic model was designed based on the expression of 8 miRNAs measured first in a profiling cohort composed of 41 primary breast cancers and 45 controls, and further validated in diverse cohorts composed of 108 primary breast cancers, 88 controls, 35 breast cancers in remission, 31 metastatic breast cancers and 30 gynecologic tumors. A receiver operating characteristic curve derived from the 8-miRNA random forest based diagnostic tool exhibited an area under the curve of 0.81. The accuracy of the diagnostic tool remained unchanged considering age and tumor stage. The miRNA signature correctly identified patients with metastatic breast cancer. The use of the classification model on cohorts of patients with breast cancers in remission and with gynecologic cancers yielded prediction distributions similar to that of the control group. Using a multivariate supervised learning method and a set of 8 circulating miRNAs, we designed an accurate, minimally invasive screening tool for breast cancer. [less ▲]

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See detailReconstruction of the envelope of non-Gaussian structural responses with principal static wind loads
Blaise, Nicolas ULg; Canor, Thomas; Denoël, Vincent ULg

in Journal of Wind Engineering & Industrial Aerodynamics (2015), 149

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these ... [more ▼]

In current practice, structural engineers commonly focus on the wind-resistant design by means of static wind loads. In case of non-Gaussianities, there is room for improvement to properly derive these static loads. First, this paper extends in a non-Gaussian context the concept of the load-response correlation (LRC) method establishing equivalent static wind loads (ESWLs). This is done by a proper recourse to the new concept of conditional expected static wind load and a proposed bicubic model for the joint and conditional distribution functions. Second, this paper investigates the envelope reconstruction problem targeting the efficient reconstruction of the envelope values of a set of non-Gaussian structural responses by means of principal static wind loads (PSWLs). They have been introduced in a Gaussian context and are obtained by a singular value decomposition of ESWLs. This paper addresses the extension of PSWLs to non-Gaussian structural responses, as well. The developments apply to structures with a linear behavior and subjected to an aerodynamic pressure field exhibiting mildly to strongly non-Gaussian features. In this context, the well-known load-response correlation and conditional sampling methods are used for comparisons. This study is undertaken for quasi-static analysis of structures and is illustrated on a low-rise building. [less ▲]

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See detailAnticoherence of spin states with point-group symmetries
Baguette, Dorian ULg; Damanet, François ULg; Giraud, Olivier et al

in Physical Review A (2015), 92

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana ... [more ▼]

We investigate multiqubit permutation-symmetric states with maximal entropy of entanglement. Such states can be viewed as particular spin states, namely anticoherent spin states. Using the Majorana representation of spin states in terms of points on the unit sphere, we analyze the consequences of a point-group symmetry in their arrangement on the quantum properties of the corresponding state. We focus on the identification of anticoherent states (for which all reduced density matrices in the symmetric subspace are maximally mixed) associated with point-group-symmetric sets of points. We provide three different characterizations of anticoherence and establish a link between point symmetries, anticoherence, and classes of states equivalent through stochastic local operations with classical communication. We then investigate in detail the case of small numbers of qubits and construct infinite families of anticoherent states with point-group symmetry of their Majorana points, showing that anticoherent states do exist to arbitrary order. [less ▲]

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See detailSkin ultrastructural similarities between fibromyalgia and Ehlers-Danlos syndrome hypermobility type
Hermanns-Lê, Trinh ULg; PIERARD, Gérald ULg

in Journal of osteoarthritis (2015), 1(1),

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established ... [more ▼]

Fibromyalgia (FM) and hypermobility type Ehlers-Danlos syndrome (EDSH) share a series of common clinical signs. A clinical distinction between both diseases is occasionally difficult to be established. The physical changes observed in the mechanical properties of skin and joints do not distinctly distinguish these disorders. In addition, similar ultrastructural dermal changes are observed in both EDSH and some FM cases. The molecular alterations remain largely undisclosed in both diseases. As a result, EDSH remains undiagnosed in some FM patients. This condition deteriorates quality of life and possibly leads to prominent health problems. [less ▲]

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See detailValidation of a multicolor staining to monitor phosphoSTAT5 levels in regulatory T-cell subsets
Ehx, Grégory ULg; Hannon, Muriel ULg; BEGUIN, Yves ULg et al

in Oncotarget (2015)

BACKGROUND: Regulatory T cells (Tregs) are key players in immune tolerance. They express the transcription factor FOXP3 and are dependent of the STAT5 signaling for their homeostasis. So far, the study of ... [more ▼]

BACKGROUND: Regulatory T cells (Tregs) are key players in immune tolerance. They express the transcription factor FOXP3 and are dependent of the STAT5 signaling for their homeostasis. So far, the study of phosphorylated epitopes by flow cytometry required treating the cells with methanol, which is harmful for several epitopes. METHODS: Here we assessed whether the PerFix EXPOSE reagent kit (PFE) (Beckman Coulter) allowed monitoring the phosphorylation level of STAT5 in Treg subpopulations together with complex immunophenotyping. Results observed with the PFE kit were compared to those observed without cell permeabilization for surface markers, with paraformaldehyde permeabilization for non-phosphorylated intracellular epitopes, and with methanol-based permeabilization for phosphoSTAT5 staining. RESULTS: In human PBMCs, the PFE kit allowed the detection of surface antigens, FOXP3, KI67 and phosphoSTAT5 in similar proportions to what was observed without permeabilization (for surface antigens), or with PFA or methanol permeabilizations for FOXP3/KI67 and phosphoSTAT5, respectively. Comparable observations were made with murine splenocytes. Further, the PFE kit allowed determining the response of different human and murine Treg subsets to IL-2. It also allowed demonstrating that human Treg subsets with the highest levels of phosphoSTAT5 had also the highest suppressive activity in vitro, and that anti-thymocyte glogulin (ATG) induced Treg independently of the STAT5 pathway, both in vitro and in vivo. CONCLUSIONS: We have validated a multicolor staining method that allows monitoring phosphoSTAT5 levels in Treg subsets. This staining could be useful to monitor responses of various Treg subsets to IL-2 therapy. [less ▲]

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See detailDendroécologie du hêtre en forêt de Soignes : Les cernes des arbres nous renseignent sur les changements récents et futurs
Latte, Nicolas ULg; Kint, Vincent; Drouet, Thomas et al

in FORÊT.NATURE (2015), 137(Octobre-Novembre-Décembre), 24-37

La dendroécologie combine la dendrochronologie et l’écologie forestière. Elle a permis d’analyser les cernes des hêtres de la forêt de Soignes et de comparer les tendances dans le contexte plus large des ... [more ▼]

La dendroécologie combine la dendrochronologie et l’écologie forestière. Elle a permis d’analyser les cernes des hêtres de la forêt de Soignes et de comparer les tendances dans le contexte plus large des hêtraies de Belgique. Depuis la fin des années ‘70, le hêtre devient de plus en plus sensible au climat, surtout en Soignes. L’augmentation de la fréquence et de l’intensité des sécheresses printanières et des canicules ont affecté négativement la croissance annuelle des hêtres. Les prévisions climatiques pour le 21e siècle présage une rapide aggravation. Les risques encourus par l’essence aboutissent à de nouvelles réflexions sur la gestion de la hêtraie de Soignes. Pour les peuplements existants : une sylviculture dynamique avec des éclaircies fortes et fréquentes afin de limiter la concurrence pour les ressources et favoriser la croissance individuelle des arbres. Pour la régénération des vieilles hêtraies : les remplacer par d’autres essences plus tolérantes ou favoriser le mélange et confiner le hêtre aux surfaces limitées des stations les plus fraîches. Un risque mesuré pourrait être pris en regard du rôle patrimonial des hêtraies cathédrales en Soignes. Toutefois, ce faciès peut être obtenu avec d’autres essences. [less ▲]

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See detailAbility of Tuta absoluta (Lepidoptera: Gelechiidae) to develop on alternative host plant species
Bawin, Thomas ULg; Dujeu, David; De Backer, Lara ULg et al

in Canadian Entomologist (2015)

The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host ... [more ▼]

The tomato leafminer, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae), is a widespread devastating pest reported to develop on economically important solanaceous crops. The characterization of its host range could help to understand and prevent the dispersion behavior of the insect in the environment. In this study, the ability of T. absoluta to develop on 12 cultivated or non-cultivated plants including Solanaceae, Chenopodiaceae, Convolvulaceae, Fabaceae and Malvaceae species under laboratory conditions was assessed. For each plant species, we monitored the development times of immature stages, survival, sex ratios and adult fecundity rates. All the 6 tested non-solanaceous plants, including Chenopodium, Convolvulus and Malva species, were not able to sustain (i.e. allow growth and development) T. absoluta larvae. Among Solanaceae, Solanum species were the most suitable host plants for the pest, but others could be opportunistically colonized with fewer incidences. T. absoluta appears to be strongly related to solanaceous plants which would predominantly support self-sustaining field populations. Preventing crop infestation by removing potential host plants in the immediate field vicinity and culture rotations with non-solanaceous crops is of primary importance. [less ▲]

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See detailNumerical and experimental study of the glass flow and heat transfer in the continuous glass fiber drawing process
Chouffart, Quentin ULg; Simon, Philippe; Terrapon, Vincent ULg

in Journal of Materials Processing Technology (2015)

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is ... [more ▼]

The manufacturing process of glass fibers used for the reinforcement of composite materials consistsin drawing a free jet of a molten glass at high temperature into fibers using a winder. This process is sensitive to numerous disturbances that can cause the fiber to break during the drawing process, and thus reduce the process efficiency. The underlying physics of the forming of a single fiber is investigated here through numerical simulations, and results are validated with measurements obtained on a dedicated experimental unit. Both a two-dimensional axisymmetric and a simplified one-dimensional model are used to simulate the high-temperature region before glass transition. The influence of key parameters and physical mechanisms on the internal stress is investigated through a sensitivity analysis. The simplified model is then used to identify the optimal operating window and to assess the impact of temperature inhomogeneities at the bushing plate. Results show that the initial region close to the tip is critical, and that a low cooling rate reduces the stress. Operating at high tip temperature, large drawing velocity and small tip radius is then found to be the best strategy to minimize the stress. Finally, it is shown that the heat pattern of the bushing plate is one of the most important causes for disturbance in the process. [less ▲]

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See detailWater-Energy Nexus in Shared River Basins: How Hydropower Shapes Cooperation and Coordination
Kouangpalath, Phimthong ULg; Meijer, Karen

in Topical Issue on Sustainability in the Water-Energy-Food Nexus (2015), 2

The construction of hydropower plants on transboundary rivers is seldom done with equal benefits to all riparians, and therefore presents coordination and cooperation challenges. Without a supra-national ... [more ▼]

The construction of hydropower plants on transboundary rivers is seldom done with equal benefits to all riparians, and therefore presents coordination and cooperation challenges. Without a supra-national authority in charge of transboundary river basins, coordination between sectors (water, energy and environment) and cooperation between countries largely depends on willingness of the individual nation states and the power relations between these countries. This paper discusses how the interests and relative power positions of actors in transboundary water management shape the outcomes, and what roles are played by River Basin Organisations and foreign investors (especially in hydropower development). These issues are illustrated with examples from the Mekong river in Southeast Asia (Laos, Thailand, Cambodia and Vietnam), the Euphrates-Tigris (Turkey, Syria, Iraq, Iran and Kuwait) and the Çoruh in Turkey and Georgia. [less ▲]

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See detailMolecular detection of six (endo-) symbiotic bacteria in Belgian mosquitoes: first step towards the selection of appropriate paratransgenesis candidates
Raharimalala, Fara Nantenaina; Boukraa, Slimane ULg; Bawin, Thomas ULg et al

in Parasitology Research (2015)

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors ... [more ▼]

Actually, the use of symbiotic bacteria is one of alternative solution to avoid vector resistance to pesticides. In Belgium, among 31 identified mosquito species, 10 were considered as potential vectors. Given to introduction risks of arbovirosis, the purpose of this study was to investigate the presence of symbiosis bacteria in potential mosquito vectors. Eleven species caught from 12 sites in Belgium were used: Culex pipiens s.l., Culex torrentium, Culex hortensis, Anopheles claviger, Anopheles maculipennis s.l., Anopheles plumbeus, Culiseta annulata, Ochlerotatus geniculatus, Ochlerotatus dorsalis, Aedes albopictus, and Coquillettidia richiardii. Six genera of symbiotic bacteria were screened: Wolbachia sp., Comamonas sp, Delftia sp., Pseudomonas sp., Acinetobacter sp., and Asaia sp.Atotal of 173 mosquito individuals (144 larvae and 29 adults) were used for the polymerase chain reaction screening. Wolbachia was not found in any Anopheles species nor Cx. torrentium. A total absence of Comamonas and Delftia was observed in all species. Acinetobacter, Pseudomonas, and Asaia were found in most of species with a high prevalence for Pseudomonas. These results were discussed to develop potential strategy and exploit the variable occurrence of symbiotic bacteria to focus on them to propose biological ways of mosquito control. [less ▲]

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See detailAnalysis of the adoption of the passion fruit (Passflora Edulis) in farming systems, Matongo Burundi
Bashangwa Mpozi, Bosco ULg; Musabanganji, Edouard ULg; Ndimanya, Patrice et al

in Poljoprivreda i Sumarstvo = Agriculture and Forestry (2015), 61(4), 117-124

The commercial potential of passion fruit is expanding as demand for both fresh fruit and processed juice is increasing in Burundi. Due to the current situation with an unstable market of traditional ... [more ▼]

The commercial potential of passion fruit is expanding as demand for both fresh fruit and processed juice is increasing in Burundi. Due to the current situation with an unstable market of traditional crops for export, farmers in Matongo have embraced passion fruit as a new source of household income. As the crop generates substantial revenues for farmers, wholesalers and processors, it is important to sustain this sector. The purpose of this research was to compare four variants of diffusionist arguments (age, sex, household size and level of education) and their expression into adoption. Comparative descriptive statistical analysis between adopters and non-adopters to test the essential factors, and participatory survey methods for gathering information were used. Our results showed a highly significant difference between the category of adopters and non-adopters at p < 0.01. However, no significant difference was found between adopters and non-adopters within level of education. Data on the level of education demonstrated that those with little or no education adopted more passion fruit [illiterates (48.9%) and primary level (45.9%)] than these with secondary level (5.2%). The heads of household adopters and non-adopters are mainly men at a rate of 83.7 and 88.3 %, and household size was not a discriminating factor. The factors that promote the adoption of passion fruit are high yield and continuous production, high market demand and permanent source of revenue. Defining only a few variables to analyse the adoption trend could mislead our findings. A participatory approach seems most appropriate for understanding adoption and non-adoption of innovation [less ▲]

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See detailL'Italia e i processi di decolonizzazione : il caso del Congo belga (1957-1960)
Genin, Vincent ULg

in Ventunesimo Secolo (2015), 36(Anno XIV (Giugno 2015)), 105-138

This article, based on unpusblished archives, is devoted to the question : what was the impact of the decolonization of the Belgian Congo on Italian foreign Policy ((1957-1960) ? Facing a shared reality ... [more ▼]

This article, based on unpusblished archives, is devoted to the question : what was the impact of the decolonization of the Belgian Congo on Italian foreign Policy ((1957-1960) ? Facing a shared reality with Belgium, the aim of this research is to study the attitude of Italian foreign policy, forced to maintain a balance between its position in the UN ; its relation with Belgium ; and the need to maintain influence, mainly through Financial penetration, in the newly independent Congo [less ▲]

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See detailPublic health impact and cost-effectiveness of dairy products supplemented with vitamin D in prevention of osteoporotic fractures
Ethgen, Olivier ULg; Hiligsmann, Mickaël; Burlet, Nansa et al

in Archives of Public Health (2015)

Background: Dietary sources of calcium and vitamin D are recommended as a first-line strategy in prevention of osteoporosis-related fractures but their public health and economic impact has never been ... [more ▼]

Background: Dietary sources of calcium and vitamin D are recommended as a first-line strategy in prevention of osteoporosis-related fractures but their public health and economic impact has never been studied. Methods: We designed a population-based model to forecast the potential health outcomes and medical effectiveness of the daily administration of dairy supplements containing 800 IU of vitamin D and 1 g of calcium in cohorts of subjects, from both genders, aged 50, 60, 70 and 80 years. Annual costs of dairy products were tested at €150, €250 and €350. Results: In total, the daily intake of vitamin-D rich dairy products reduces by 30,376 and 16,105 events the number of osteoporotic fractures in women and men respectively and permits to gain 6605 and 6144 life-years, in women and men respectively. This intervention is cost-effective from 70 years on in the general population and from 60 years on in patients at increased risk of osteoporotic fractures. Conclusion: The recommendation to use dairy products as the preferred source of calcium and vitamin D in aging males and females is supported by public health and health economic analyses. [less ▲]

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See detailDynamics of Internalization and Recycling of the Pro-Metastatic Membrane Type 4-Matrix Metalloproteinase (MT4-MMP) in Breast Cancer Cells
Truong, Alice ULg; Yip, Cassandre ULg; PAYE, Alexandra ULg et al

in FEBS Journal (2015)

MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes ... [more ▼]

MT4-MMP (MMP17) is a glycosylphosphatidyl inositol (GPI)-anchored membrane-type MMP expressed on the cell surface of human breast cancer cells. In triple negative breast cancer cells, MT4-MMP promotes primary tumor growth and lung metastases. Although trafficking and internalization of the transmembrane MT1-MMP have been extensively investigated, little is known about the regulatory mechanisms of the GPI-anchored MT4-MMP. Here, we investigated the fate and cellular trafficking of MT4-MMP by analyzing its homophilic complex interactions, internalization and recycling dynamics compared to an inert form, MT4-MMP-E249A. Oligomeric and dimeric complexes were analyzed by co-transfection of cells with FLAG- or Myc-tagged MT4-MMP by reducing and non-reducing immunoblots and co-immunoprecipitation experiments. The trafficking of MT4-MMP was studied using an antibody feeding assay and confocal microscopy analysis or cell surface protein biotinylation and Western blot analysis. We demonstrate that MT4-MMP forms homophilic complexes at the cell surface, internalizes in early endosomes, and some of the enzyme is either auto-degraded or recycled to the cell surface. Our data indicate that MT4-MMP is internalized by the CLIC/GEEC pathway, a mechanism that differs from other MT-MMP members. Although MT4-MMP localizes with caveolin-1, MT4-MMP internalization was not affected by inhibitors of caveolin-1 or clathrin endocytosis pathways but was reduced by cdc42 or RhoA silencing with siRNA. We provide a new mechanistic insight into the regulatory mechanisms of MT4-MMP, which may have implications in the design of novel therapeutic strategies for metastatic breast cancer. This article is protected by copyright. All rights reserved. [less ▲]

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See detailIntegration Analysis of Three Omics Data Using Penalized Regression Methods: An Application to Bladder Cancer
Pineda San Juan, Silvia ULg; Real, Francisco X; Kogevinas, Manolis et al

in PLoS Genetics (2015)

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See detailImpact of cyclonic and anticyclonic activity on Greenland ice sheet surface mass balance variation during 1980–2013
Chen, L.; Fettweis, Xavier ULg; Knudsen, E. et al

in International Journal of Climatology (2015)

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective ... [more ▼]

The Greenland ice sheet (GrIS) has experienced dramatic ice loss during recent decades, but the drivers of the surface mass balance (SMB) variation remain unclear. From a dynamical perspective, extratropical cyclones and anticyclones are the major systems influencing Greenland weather conditions. Seasonal cyclonic and anticyclonic activities have been quantified for the area of 50°–90°N, 80°W–10°E during 1980–2013. Based on a singular value decomposition (SVD) analysis, we investigated the role of synoptic scale cyclonic and anticyclonic activities in determining snow accumulation (SA) and surface air temperature (SAT). Thus, the SA-driven and melt-driven SMB variability has been determined. SA-related synoptic patterns identified from the leading and the second SVD modes explain up to 80% of the inter-annual SMB variance, especially in southern and northwestern Greenland, where we found the largest and second largest amount of annual SA. SAT-related patterns account for up to 80% of the inter-annual SMB variation along the west and northwest coast of Greenland, where significant surface mass loss has been observed over the last decades. It should be noted that the negative phase of the SA-related pattern derived from the first SVD mode in June-July-August and the positive phase of the SAT-related (anti)cyclonic patterns have occurred more frequently since 2005, meaning that the phase change of these patterns has made a major contribution to the accelerated GrIS surface ice loss during recent years. [less ▲]

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See detailSerum calcitriol concentrations measured with a new direct automated assay in a large population of adult healthy subjects and in various clinical situations
Souberbielle, JC; CAVALIER, Etienne ULg; DELANAYE, Pierre ULg et al

in Clinica Chimica Acta (2015), 451 (Pt B)

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol ... [more ▼]

The measurement of calcitriol [1,25(OH2)D], is important for the differential diagnosis of several disorders of calcium/phosphorus metabolism but is time-consuming and tricky. We measured serum calcitriol with a new automated direct assay on the Liaison XL platform in 888 healthy French Caucasian subjects aged 18–89 years, 32 patients with a surgically-proven PHPT, 32 pregnant women at the end of the first and at the end of the third trimester, and 24 dialysis patients before and after one year of supplementationwith vitamin D3 or placebo. The mean calcitriol concentration (±SD) in the healthy population was 52.9 ± 14.5 ng/L with a 95% CI interval of 29–83.6 ng/L. In PHPT patients, calcitriol concentration was 81.6±29.0 ng/L, 15 of them (46.9%) having a concentration N83.6 ng/L. In pregnant women, calcitriol was 80.4 ± 26.4 ng/L at the end of the first trimester, and 113.1±33.0 ng/L at the end of the third trimester, 12 (37.5%) and 26 (81.3%) of them having a calcitriol concentration N83.6 ng/L at the first and third trimesters respectively. In 14 dialysis patients, calcitriol was 9.5±7.7 ng/L and rose to 19.3 ng/L after one year of supplementation with 50,000 IU vitamin D3/month. In 10 other dialysis patients, calcitriol was 9.9±2.9 ng/L and remained stable (12.4±3.7 ng/L) after one year of placebo. In conclusion, this new automated calcitriol assay, in addition to presenting excellent analytical performances, gives the expected variations in patients compared to “normal” values obtained in an extensive reference population [less ▲]

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See detailFraming the Concept of Citizenship in a Contested Nation-State: Reflections on Kosovo
Mazur Kumric, Nives ULg

in Pécs Journal of International and European Law (2015), (II), 70-88

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty ... [more ▼]

Since the inception of the Republic of Kosovo in February 2008, the contouring of its statehood has been predominantly affected by four interwoven factors: the partial recognition of its sovereignty, perplexed inter-ethnic relations, profound international interference and parallel jurisdictions with the Republic of Serbia. The efforts put forth to conceptualise the meaning and scope of Kosovo citizenship in such a sensitive socio-political environment have proved particularly challenging. This paper aims to provide an analytical framework for determining essential elements of Kosovo citizenship, with particular emphasis on its practical and ideological implications for the multicultural, yet ethnically divided society. This is done through an assessment of the key nation-constituting legal norms as well as the deep-rooted ethnic tensions sparked by conflicting perceptions of Kosovo's statehood by the majority (Kosovo Albanian) and minority (Kosovo Serbian) population. By formal definition, Kosovo is an indivisible state of all citizens, however, polarised majority-minority interests have impinged the constitutionally guaranteed civic spirit of the entity, thereby threatening not only national, but also wider international security and integrity. With the purpose of determining and delineating labyrinthine intersections of a contested nation-state, citizenship, 'communities' and security, the paper offers a comprehensive theoretical analysis of the respective quadrilateral nexus. [less ▲]

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See detailInfluence of process operating conditions on solvent thermal and oxidative degradation in post-combustion CO2 capture
Léonard, Grégoire ULg; Crosset, Cyril; Toye, Dominique ULg et al

in Computers & Chemical Engineering (2015), 83

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data ... [more ▼]

The CO2 post-combustion capture with amine solvents is modeled as a complex system interconnecting process energy consumption and solvent degradation and emission. Based on own experimental data, monoethanolamine degradation is included into a CO2 capture process model. The influence of operating conditions on solvent loss is validated with pilot plant data from literature. Predicted solvent consumption rates are in better agreement with plant data than any previous work, and pathways are discussed to further refine the model. Oxidative degradation in the absorber is the largest cause of solvent loss while thermal degradation does not appear as a major concern. Using a single model, the process exergy requirement decreases by 10.8% and the solvent loss by 11.1% compared to our base case. As a result, this model provides a practical tool to simultaneously minimize the process energy requirement and the solvent consumption in post-combustion CO2 capture plants with amine solvents. [less ▲]

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See detailAssessing the O2 budget under sea ice: An experimental and modelling approach
Moreau, S.; Kaartokallio, H.; Vancoppenolle, M. et al

in Elementa: Science of the Anthropocene (2015), 3(000080),

The objective of this study was to assess the O2 budget in the water under sea ice combining observations and modelling. Modelling was used to discriminate between physical processes, gas-specific ... [more ▼]

The objective of this study was to assess the O2 budget in the water under sea ice combining observations and modelling. Modelling was used to discriminate between physical processes, gas-specific transport (i.e., ice-atmosphere gas fluxes and gas bubble buoyancy) and bacterial respiration (BR) and to constrain bacterial growth efficiency (BGE). A module describing the changes of the under-ice water properties, due to brine rejection and temperature-dependent BR, was implemented in the one-dimensional halo-thermodynamic sea ice model LIM1D. Our results show that BR was the dominant biogeochemical driver of O2 concentration in the water under ice (in a system without primary producers), followed by gas specific transport. The model suggests that the actual contribution of BR and gas specific transport to the change in seawater O2 concentration was 37% during ice growth and 48% during melt. BGE in the water under sea ice, as retrieved from the simulated O2 budget, was found to be between 0.4 and 0.5, which is in line with published BGE values for cold marine waters. Given the importance of BR to seawater O2 in the present study, it can be assumed that bacteria contribute substantially to organic matter consumption and gas fluxes in ice-covered polar oceans. In addition, we propose a parameterization of polar marine bacterial respiration, based on the strong temperature dependence of bacterial respiration and the high growth efficiency observed here, for further biogeochemical ocean modelling applications, such as regional or large-scale Earth System models [less ▲]

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See detailThe return of Turkey to the Western Balkans: a challenge or an opportunity for the European Union?
Lika, Liridon ULg

in Politikon: IAPSS Journal of Political Science (2015)

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See detailEvolution of the Northern Rockweed, Fucus distichus, in a Regime of Glacial Cycling: Implications for Benthic Algal Phylogenetics
Laughinghouse, Haywood, Dail; Müller, Kirsten; Adey, Walter et al

in PLoS ONE (2015), 10(12), 0143795

Northern hemisphere rockweeds (Fucus) are thought to have evolved in the North Pacific and then spread to the North Atlantic following the opening of the Bering Strait. They have dispersed and widely ... [more ▼]

Northern hemisphere rockweeds (Fucus) are thought to have evolved in the North Pacific and then spread to the North Atlantic following the opening of the Bering Strait. They have dispersed and widely speciated in the North Atlantic and its tributary seas. Fucus distichus is likely near the ancestral member of this genus, and studies have shown that there are several species/subspecies in this complex (i.e. F. evanescens and F. gardneri). We used phylogenetic and haplotype analyses to test the phylogenetic relationships and biogeogra- phy of F. distichus. Our data and subsequent analyses demonstrate that, unlike previous studies that lacked samples from an extensive geographical area of the Arctic and Subarc- tic, there is a distinct Arctic haplotype that is the source of subspecies in both the North Pacific and North Atlantic. Fucus distichus occupies a low tide zone habitat, and in Arctic/ Subarctic regions it is adapted to the severe stress of sea ice coverage and disturbance dur- ing many months per year. We hypothesize that the very large geographic area of Arctic and Subarctic rocky shores available to this species during interglacials, supported by large Arctic/Subarctic fringe areas as well as unglaciated refugia during glacial cycles, provided a robust population and gene pool (described by the Thermogeographic Model). This gene pool dilutes that of the more fragmented and area-limited Temperate/Boreal area popula- tions when they are brought together during glacial cycles. We suggest that similar subspe- cies complexes for a variety of Arctic/Subarctic shore biota should be examined further in this context, rather than arbitrarily being split up into numerous species. [less ▲]

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See detailAnalytical Tools and Strategic Approach to Detect Poor Quality Medicines, Identify Unknown Components, and Timely Alerts for Appropriate Measures: Case Study of Antimalarial Medicines
Habyalimana, Védaste ULg; Mbinze Kindenge, Jérémie; Kalenda Tshilombo, Nicodème ULg et al

in American Journal of Analytical Chemistry (2015), 6

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in ... [more ▼]

Nowadays, the circulation of poor quality medicines is becoming an alarming worldwide phenomenon with serious public health and socio-economic concerns. The situation is particularly critical in developing countries where drug quality assurance and regulatory systems for drug manufacturing, importation, distribution and sales are weak. A sustained vigilance on poor quality medicines that regroup counterfeit/falsified, substandard and degraded medicines is therefore required to ensure patient safety and genuine medicines integrity. A case situation is illustrated including a strategic approach and analytical tools that were found useful to detect poor quality medicines, identify unknown components, and timely alerts for appropriate measures against the spread of those harmful products. Several suspected medicines randomly sampled in several strategic Rwandan areas were firstly check-controlled by means of visual inspection and then applying several analytical techniques from simple to more complex ones. The following medicines were studied: quinine sulfate tablets, artemisinin-based combination tablets, and artesunate powders for injection. Taking into account the pharmaceutical forms and the chemical characteristics, the following tests were applied: uniformity of mass, friability, disintegration, fluorescence, identification and assay. They were followed by more complex analytical techniques that allowed more comprehension of abnormal findings among which the presence of a wrong active pharmaceutical ingredient in quinine sulfate tablets which is mainly discussed in this paper to illustrate a strategic approach and various analytical tools that can be used in detecting and identifying unknown component in poor quality medicines. [less ▲]

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See detailLes lieux d’habitation des écrivains belges francophones à Bruxelles (1930-1960). Premiers jalons pour une histoire sociogéographique
Debroux, Tatiana; Vanderpelen-Diagre, Cécile; Dozo, Björn-Olav ULg

in Textyles : Revue des Lettres Belges de Langue Française (2015), 47

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See detailTRAPPIST photometry and imaging monitoring of comet C/2013 R1 (Lovejoy): Implications for the origin of daughter species
Opitom, Cyrielle ULg; Jehin, Emmanuel ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (2015), 584

We report the results of the narrow-band photometry and imaging monitoring of comet C/2013 R1 (Lovejoy) with the robotic telescope TRAPPIST (La Silla observatory). We gathered around 400 images over 8 ... [more ▼]

We report the results of the narrow-band photometry and imaging monitoring of comet C/2013 R1 (Lovejoy) with the robotic telescope TRAPPIST (La Silla observatory). We gathered around 400 images over 8 months pre- and post-perihelion between September 12, 2013 and July 6, 2014. We followed the evolution of the OH, NH, CN, C[SUB]3[/SUB], and C[SUB]2[/SUB] production rates computed with the Haser model, as well as the evolution of the dust production. All five gas species display an asymmetry about perihelion, since the rate of brightening is steeper than the rate of fading. The study of the coma morphology reveals gas and dust jets that indicate one or several active zone(s) on the nucleus. The dust, C[SUB]2[/SUB], and C[SUB]3[/SUB] morphologies present some similarities, while the CN morphology is different. OH and NH are enhanced in the tail direction. The study of the evolution of the comet activity shows that the OH, NH, and C[SUB]2[/SUB] production rate evolution with the heliocentric distance is correlated to the dust evolution. The CN and, to a lesser extent, the C[SUB]3[/SUB] do not display such a correlation with the dust. This evidence and the comparison with parent species production rates indicate that C[SUB]2[/SUB] and C[SUB]3[/SUB], on one hand, and OH and NH, on the other, could be - at least partially - released from organic - rich grains and icy grains. On the contrary, all evidences point to HCN being the main parent of CN in this comet. [less ▲]

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See detailKroniek van het Nederlandse nationaliteitsrecht 2014-2015
Vonk, Olivier ULg

in Asiel- en Migrantenrecht (2015)

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See detailLarger and faster: revised properties and a shorter orbital period for the WASP-57 planetary system from a pro-am collaboration
Southworth, John; Mancini, L.; Tregloan-Reed, J. et al

in Monthly Notices of the Royal Astronomical Society (2015), 454

Transits in the WASP-57 planetary system have been found to occur half an hour earlier than expected. We present 10 transit light curves from amateur telescopes, on which this discovery was based, 13 ... [more ▼]

Transits in the WASP-57 planetary system have been found to occur half an hour earlier than expected. We present 10 transit light curves from amateur telescopes, on which this discovery was based, 13 transit light curves from professional facilities which confirm and refine this finding, and high-resolution imaging which show no evidence for nearby companions. We use these data to determine a new and precise orbital ephemeris, and measure the physical properties of the system. Our revised orbital period is 4.5 s shorter than found from the discovery data alone, which explains the early occurrence of the transits. We also find both the star and planet to be larger and less massive than previously thought. The measured mass and radius of the planet are now consistent with theoretical models of gas giants containing no heavy-element core, as expected for the subsolar metallicity of the host star. Two transits were observed simultaneously in four passbands. We use the resulting light curves to measure the planet's radius as a function of wavelength, finding that our data are sufficient in principle but not in practise to constrain its atmospheric properties. We conclude with a discussion of the current and future status of transmission photometry studies for probing the atmospheres of gas-giant transiting planets. [less ▲]

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See detailThe HARPS-N Rocky Planet Search. I. HD 219134 b: A transiting rocky planet in a multi-planet system at 6.5 pc from the Sun
Motalebi, F.; Udry, S.; Gillon, Michaël ULg et al

in Astronomy and Astrophysics (2015), 584

We know now from radial velocity surveys and transit space missions that planets only a few times more massive than our Earth are frequent around solar-type stars. Fundamental questions about their ... [more ▼]

We know now from radial velocity surveys and transit space missions that planets only a few times more massive than our Earth are frequent around solar-type stars. Fundamental questions about their formation history, physical properties, internal structure, and atmosphere composition are, however, still to be solved. We present here the detection of a system of four low-mass planets around the bright (V = 5.5) and close-by (6.5 pc) star HD 219134. This is the first result of the Rocky Planet Search programme with HARPS-N on the Telescopio Nazionale Galileo in La Palma. The inner planet orbits the star in 3.0935 ± 0.0003 days, on a quasi-circular orbit with a semi-major axis of 0.0382 ± 0.0003 AU. Spitzer observations allowed us to detect the transit of the planet in front of the star making HD 219134 b the nearest known transiting planet to date. From the amplitude of the radial velocity variation (2.25 ± 0.22 ms[SUP]-1[/SUP]) and observed depth of the transit (359 ± 38 ppm), the planet mass and radius are estimated to be 4.36 ± 0.44 M[SUB]⊕[/SUB] and 1.606 ± 0.086 R[SUB]⊕[/SUB], leading to a mean density of 5.76 ± 1.09 g cm[SUP]-3[/SUP], suggesting a rocky composition. One additional planet with minimum-mass of 2.78 ± 0.65 M[SUB]⊕[/SUB] moves on a close-in, quasi-circular orbit with a period of 6.767 ± 0.004 days. The third planet in the system has a period of 46.66 ± 0.08 days and a minimum-mass of 8.94 ± 1.13 M[SUB]⊕[/SUB], at 0.233 ± 0.002 AU from the star. Its eccentricity is 0.46 ± 0.11. The period of this planet is close to the rotational period of the star estimated from variations of activity indicators (42.3 ± 0.1 days). The planetary origin of the signal is, however, thepreferred solution as no indication of variation at the corresponding frequency is observed for activity-sensitive parameters. Finally, a fourth additional longer-period planet of mass of 71 M[SUB]⊕[/SUB] orbits the star in 1842 days, on an eccentric orbit (e = 0.34 ± 0.17) at a distance of 2.56 AU. The photometric time series and radial velocities used in this work are available in electronic form at the CDS via anonymous ftp to <A href="http://cdsarc.u-strasbg.fr">http://cdsarc.u-strasbg.fr</A> (ftp://130.79.128.5) or via <A href="http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A72">http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/584/A72</A> [less ▲]

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See detailA cross-sectional study to evaluate factors related to condom use with commercial sexual partners in workers from Ecuadorian companies
Cabezas, Maria C.; Fornasini, Marco; Dardenne, Nadia ULg et al

in BMC Public Health (2015), 15(1),

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See detailDrug-polymer electrostatic complexes as new structuring agents for the formation of drug-loaded ordered mesoporous silica
Molina, Emilie; Warnant, Jérôme; Mathonnat, Mélody et al

in Langmuir (2015), 31(47), 12839-12844

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases ... [more ▼]

Using aminoglycoside antibiotics as drug models, it was shown that electrostatic complexes between hydrophilic drugs and oppositely charged double-hydrophilic block copolymers can form ordered mesophases. This phase behaviour was evidenced by using poly(acrylic acid)-block-poly(ethylene oxide) block copolymers in the presence of silica precursors and, this allowed preparing drug-loaded mesoporous silica directly from the drug-polymer complexes. The novel synthetic strategy of the hybrid materials is highly efficient, avoiding waste and multi-step processes; it also ensures optimal drug loading and provides pH-dependence of the drug release from the materials. [less ▲]

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See detailPolarization microlensing in the quadruply imaged broad absorption line quasar H1413+117
Hutsemekers, Damien ULg; Sluse, Dominique ULg; Braibant, Lorraine ULg et al

in Astronomy and Astrophysics (2015), 584

We have obtained spectropolarimetric observations of the four images of the gravitationally lensed broad absorption line quasar H1413+117. The polarization of the microlensed image D is significantly ... [more ▼]

We have obtained spectropolarimetric observations of the four images of the gravitationally lensed broad absorption line quasar H1413+117. The polarization of the microlensed image D is significantly different, both in the continuum and in the broad lines, from the polarization of image A, which is essentially unaffected by microlensing. The observations suggest that the continuum is scattered off two regions, spatially separated, and producing roughly perpendicular polarizations. These results are compatible with a model in which the microlensed polarized continuum comes from a compact region located in the equatorial plane close to the accretion disk and the non-microlensed continuum from an extended region located along the polar axis. Based on observations made with ESO Telescopes at the Paranal Observatory (Chile). ESO program ID: 386.B-0337. [less ▲]

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See detailDevelopment and validation of a short Italian UPPS-P Impulsive Behavior Scale
D'Orta, Isabella; Burnay, Jonathan ULg; Aiello, Daniela et al

in Addictive Behaviors Reports (2015), 2

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between ... [more ▼]

Impulsivity is a multidimensional construct that plays a prominent role in the development, maintenance, and relapse of addictive disorders. The UPPS-P model of impulsivity, which distinguishes between five impulsivity components (positive urgency, negative urgency, lack of perseverance, lack of premeditation, sensation seeking), has been increasingly investigated during the last decade in relation to addictive and risky behaviors. Unfortunately, it currently lacks a validated scale that allows Italian researchers and clinicians to measure impulsivity based on the UPPS-P model. The current study fills this gap by testing the psychometric properties of a short 20-item Italian scale used to assess the five dimensions of the UPPS-P model in 188 volunteer participants from the community. Confirmatory factor analysis supported a model of five distinct, but interrelated, impulsivity components. The results indicated good internal consistency (Cronbach's α ranges from .73 to .84). Construct validity was evidenced by specific relations with measures of addictive behaviors and depressive symptoms. On the whole, this study demonstrated that the Italian short UPPS-P has good psychometric properties. [less ▲]

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See detailValorisation des produits laitiers dans les ménages peuls du Nord-Est du Bénin
Chabi Toko, Roukayath ULg; Adégbidi, Anselme; Lebailly, Philippe ULg

in International Journal of Biological and Chemical Sciences (2015)

La population pastorale et agro-pastorale du Bénin détient presque la totalité du cheptel bovin national. Le lait constitue le produit le plus fréquent issu de l'élevage bovin. Une enquête a été menée ... [more ▼]

La population pastorale et agro-pastorale du Bénin détient presque la totalité du cheptel bovin national. Le lait constitue le produit le plus fréquent issu de l'élevage bovin. Une enquête a été menée dans la commune de Kalalé au sein de 16 ménages peuls afin de comprendre l'organisation de ces ménages dans la gestion du lait. Il ressort que l'organisation autour du capital lait est genre sensible: l'homme aussi bien que la femme, dans leurs rôles respectifs, contribuent à assurer la pérennité du capital bétail. Le lait est géré de façon à privilégier la consommation du ménage et à assurer la reproduction du troupeau. La rémunération du travail fournit ainsi que l'équité dans la distribution des richesses au sein du ménage peul octroi aux femmes qui sont dans le troupeau plus de bénéfices issues du lait provenant du troupeau familial. La disponibilité des produits laitiers dépend de la saison et du milieu. Le lait prévu pour la consommation humaine est gérée de sorte à avoir, une utilisation optimale du lait et de la viande, afin de combler les besoins actuels des membres du ménage, d'assurer la reproduction des biens du ménage ; avant d'alimenter le marché de produits laitiers. [less ▲]

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See detailDosage de la lumière pour maintenir la coexistence d’espèces d’ombre et de demi-ombre dans la régénération de la futaie irrégulière
Ligot, Gauthier ULg; Balandier, Philippe; Courbaud, Benoît et al

in Revue Forestière Française (2015), 3

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See detailMultivariate coefficients of variation: Comparison and influence functions
Aerts, Stéphanie ULg; Haesbroeck, Gentiane ULg; Ruwet, Christel ULg

in Journal of Multivariate Analysis (2015), 142

In the univariate setting, coefficients of variation are well-known and used to compare the variability of populations characterized by variables expressed in different units or having really different means ... [more ▼]

In the univariate setting, coefficients of variation are well-known and used to compare the variability of populations characterized by variables expressed in different units or having really different means. When dealing with more than one variable, the use of such a relative dispersion measure is much less common even though several generalizations of the coefficient of variation to the multivariate setting have been introduced in the literature. In this paper, the lack of robustness of the sample versions of the multivariate coefficients of variation (MCV) is illustrated by means of influence functions and some robust counterparts based either on the Minimum Covariance Determinant (MCD) estimator or on the S estimator are advocated. Then, focusing on two of the considered MCV’s, a diagnostic tool is derived and its efficiency in detecting observations having an unduly large effect on variability is illustrated on a real-life data set. The influence functions are also used to compute asymptotic variances under elliptical distributions, yielding approximate confidence intervals. Finally, simulations are conducted in order to compare, in a finite sample setting, the performance of the classical and robust MCV’s in terms of variability and in terms of coverage probability of the corresponding asymptotic confidence intervals. [less ▲]

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See detailPrésent et imparfait en moyen-perse et parthe: histoire, évolution et convergence
Ferrer-Losilla, Joan Josep ULg

in Estudios Iranios y Turanios (2015), 2

This paper deals with the problem of the origin of the verbal endings in Middle Persian and Parthian and seeks to show a feasible history of their evolution from proto-Iranian onwards. Starting from the ... [more ▼]

This paper deals with the problem of the origin of the verbal endings in Middle Persian and Parthian and seeks to show a feasible history of their evolution from proto-Iranian onwards. Starting from the assumption that the present indicative of Western Middle Iranian emerged from two old tenses, viz. present and imperfect, my aim is showing how both tenses converged in a single paradigm and how traces of both appear here and there. [less ▲]

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See detailLe raisonnement analogique en pathologie du langage
Krzemien, Magali ULg

in Cahiers de l'ASELF (2015), 12(4), 4-11

Le raisonnement analogique est une habileté humaine qui permet de dresser une correspondance entre deux situations à partir d’une structure relationnelle commune. Il est étroitement lié au langage puisque ... [more ▼]

Le raisonnement analogique est une habileté humaine qui permet de dresser une correspondance entre deux situations à partir d’une structure relationnelle commune. Il est étroitement lié au langage puisque ces deux habiletés s’influencent mutuellement. Ce lien a poussé plusieurs auteurs à s’intéresser aux capacités de raisonnement analogique d’enfants présentant des troubles du langage. Bien que ces enfants aient un niveau intellectuel dans la norme, différentes études montrent qu’ils auraient des difficultés par rapport à leurs pairs de même âge à réaliser des tâches analogiques variées, qu’elles soient verbales ou non. Ces difficultés semblent néanmoins s’estomper lorsque certaines compétences, comme le langage, sont contrôlées. De plus, les enfants dysphasiques semblent davantage dépendants à la similarité perceptuelle présente entre les stimuli, ce qui représente d’importantes implications pour l’acquisition du langage. [less ▲]

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See detailForeign Language Teachers’ Assessment Practices in French-Speaking Belgium’s Upper Secondary Schools: A Case Study
Noiroux, Kevin ULg

in The International Journal of Pedagogy and Curriculum (2015), 23(2),

Foreign language classroom assessment practices are a mystery, at least in Belgium. The present case study aims at shedding light on Belgian foreign languages teachers’ assessment practices in secondary ... [more ▼]

Foreign language classroom assessment practices are a mystery, at least in Belgium. The present case study aims at shedding light on Belgian foreign languages teachers’ assessment practices in secondary education. I interviewed seven teachers to know what they assessed and how often they assessed it. I also analyzed the legal provisions that teachers have to respect when they assess. The results show that teachers assess four communicative skills—listening, reading, writing, and speaking—as legally required, but also reveal that they frequently assess vocabulary and grammar, sometimes in ways that are not permitted. Furthermore, they spend a considerable amount of time assessing those skills without even being aware of it. Since these assessments only aim at verifying that the students master the skills, it may be worth investigating whether some assessments are not redundant so as to devote that time to a more productive task. [less ▲]

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See detailQu’attendent les orthophonistes des applications numériques à destination des personnes avec trouble du spectre autistique ?
Maillart, Christelle ULg; dor, Orianne ULg; Grevesse, Pascale ULg et al

in Rééducation Orthophonique (2015), 264

Numerous technogical applications dedicated to patients affected by the Autistic Spectrum Disorder (ASD) have recently emerged. Research has begun to prove the efficiency of technologies as support tools ... [more ▼]

Numerous technogical applications dedicated to patients affected by the Autistic Spectrum Disorder (ASD) have recently emerged. Research has begun to prove the efficiency of technologies as support tools for therapy for ASD sufferers. However, as far as we know, none study was focused on Speech-Language Therapist’s (SLT) needs. In order to fill this gap, three nominal groups were realized with 19 SLT working with patients with TSA. Identified needs have been ranked in importance. Results stress the importance of open-systems with fully customizable applications allowing the elaboration of individual progress based on specific therapeutic outcomes. [less ▲]

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See detailAssessment of muscle mass, muscle strength and physical performance in clinical practice: An international survey
Bruyère, Olivier ULg; Beaudart, Charlotte ULg; Reginster, Jean-Yves ULg et al

in European Geriatric Medicine (2015)

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in ... [more ▼]

Introduction: Several tools are available for the assessment of muscle mass, muscle strength and physical performance in clinical research. However, few data are available on the usage of these tools in clinical practice. Methods: This study aimed to assess their usage by means of a large online international survey. Since sarcopenia is a specific condition where the assessment of muscle mass, muscle strength and physical performance is important, the survey also assessed the tools used for the diagnosis of this geriatric syndrome. Results: The survey was completed by 255 clinicians from 55 countries across 5 continents. Among these clinicians with geriatrics, rheumatology and endocrinology as major fields of interest, 53.3% assess muscle mass in daily practice, 54.5% muscle strength and 71.4% physical performance. However, the tools used are very different and no single tool is used by all clinicians. The tools and the cut-off values used by clinicians to diagnose sarcopenia are also heterogeneous. Conclusion: Because some tools used for the assessment of muscle mass, muscle strength or physical performance in daily practice are less validated than others, a greater awareness from the clinicians of the importance of using appropriate tools is needed [less ▲]

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See detailServing the general interest with public enterprises. New forms of governance and trends in ownership
Fecher-Bourgeois, Fabienne ULg; Bance, Philippe; Obermann, Gabriel

in Annals of Public and Cooperative Economics (2015), 86(4), 529-718

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See detailIs the O2(a1Δg) Venus nightglow emission controlled by solar activity ?
Soret, Lauriane ULg; Gérard, Jean-Claude ULg

in Icarus (2015), 262

Several past studies showed that the O2(a1Δg) Venus nightglow emission at 1.27 μm is highly variable on a timescale of hours. We examine whether the intensity of this emission shows a more global trend ... [more ▼]

Several past studies showed that the O2(a1Δg) Venus nightglow emission at 1.27 μm is highly variable on a timescale of hours. We examine whether the intensity of this emission shows a more global trend linked to solar activity. [less ▲]

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See detailDominant amphipods of Posidonia oceanica seagrass meadows display considerable trophic diversity
Michel, Loïc ULg; Dauby, Patrick ULg; Gobert, Sylvie ULg et al

in Marine Ecology (2015), 36(4), 969-981

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica ... [more ▼]

Gut content examination and trophic markers (fatty acids, stables isotopes of C and N) were combined to delineate the diet of the dominant species of amphipods from Mediterranean Posidonia oceanica seagrass meadows and to highlight trophic diversity among this community. Our results indicate that, although all dominant species heavily relied on macroalgal epiphytes, considerable interspecific dietary differences existed. Carbon stable isotope ratios notably showed that some of the amphipod species favored grazing on epiphytes from leaves or litter fragments (Apherusa chiereghinii, Aora spinicornis, Gammarus aequicauda), while others like Dexamine spiniventris preferred epiphytes from rhizomes. The remaining amphipods (Caprella acanthifera, Ampithoe helleri and Gammarella fucicola) readily consumed both groups. In addition, SIAR modeling suggested that most species had a mixed diet, and relied on several food items. Fatty acid analysis and gut contents revealed that contribution of microepiphytic diatoms and of benthic and suspended particulate organic matter to the diet of amphipods were anecdotal. None of the examined species seemed to graze on their seagrass host (low 18:2(n-6) and 18:3(n-3) fatty acids contents), but G. aequicauda partly relied on seagrass leaf detritus, as demonstrated by the lesser 13C-depletion of their tissues. Overall, our findings suggest that amphipods, because of their importance in transfers of organic matter from primary producers and detritus to higher rank consumers, are key-items in P. oceanica associated food webs. [less ▲]

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See detailHunting with trapezes at Bazel-Sluis: the results of a functional analysis
Tomasso, Sonja; Rots, Veerle ULg; Perdaen, Yves et al

in Notae Praehistoricae (2015), 35

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See detailComment établir le pronostic des neuropathies périphériques tronculaires focales ?
WANG, François-Charles ULg

in Lettre du Neurologue (La) : le Courrier du Spécialiste (2015), XIX(10), 334

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See detail“Public-based-Learning”: The Place of Publics in Exploring Environmental Controversies for Pedagogical Purposes
Melard, François ULg; Denayer, Dorothée ULg; Semal, Nathalie ULg

in International Journal of Environmental and Science Education (2015), 10(6), 905-920

This article examines a 15 year-old master level seminar dedicated to the exploration of local and complex environmental issues marked by scientific or technological uncertainties. Following a pragmatic ... [more ▼]

This article examines a 15 year-old master level seminar dedicated to the exploration of local and complex environmental issues marked by scientific or technological uncertainties. Following a pragmatic learning approach, we focus our discussion on a triadic relationship between supervisors, students and various concerned publics. A local flood management controversy in Belgium will help to illustrate our approach and point to some learning outcomes. On the basis of this pedagogical experience, we propose to shift from Problem-based-learning towards Public-based-learning that rests on the comparison of the various ways a problem is defined by publics. This comparative approach allows us to deduce a plurality of modes of involvement mobilized in the management of the environmental problems. [less ▲]

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See detailAn overview of the plastic‑hinge analysis of 3D steel frames
Hoang, Van Long ULg; Nguyen, Dang-Hung; Jaspart, Jean-Pierre ULg et al

in Asia Pacific Journal on Computational Engineering (2015), 2:4

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See detailTransformed mineral phases during clay ceramic firing
El Ouahabi, Meriam ULg; Daoudi, Lachen; Hatert, Frédéric ULg et al

in Clays and Clay Minerals (2015), 62(6), 470478

Ceramic clays are one of the most complicated ceramic systems because of the very complex relationship between the behavior of minerals during the ceramic processing and the transformations during heating ... [more ▼]

Ceramic clays are one of the most complicated ceramic systems because of the very complex relationship between the behavior of minerals during the ceramic processing and the transformations during heating. A major challenge is to predict the phase transformations in clay ceramics. The aims are to establish reference data of ceramics products that can be formed based on the mineralogical composition of the local raw materials. These data, in turn, can be compared with the archaeological ceramics in order to study their origins. The mineralogical compositions and transformations during the firing (550 to 1100ºC under oxidizing conditions) of seven clayey materials sampled from the main clay deposits of Northern Morocco were evaluated by X-ray powder diffraction. Two groups of clays were evidenced according to the type of neoformed high-temperature minerals: non-calcareous clays and calcareous clays. For the non-calcareous raw materials, spinel is produced at 950°C. Cristobalite and mullite were formed above 1000ºC from clays that contain illite, kaolinite and chlorite. In clays containing vermiculite and high amount of chlorite, hematite was formed from 950°C. Firing of calcareous clays at temperatures > 950ºC yielded Ca-silicates (diopside, gehlenite and wollastonite), spinel, cristobalite, hematite and feldspars. Mullite may also form in the calcareous clay products, when the carbonates content exceeds 10%. [less ▲]

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See detailDiriger un service d'EAJE : une question centrale pour le développement de sa qualité
Pirard, Florence ULg

in Le Furet - La revue des professionnels de la PETITE ENFANCE (2015), 79

Le rôle central des responsables des services d’éducation et d’accueil des jeunes enfants (EAJE) pour le développement d’une qualité de services est souligné dans de nombreux rapports internationaux ... [more ▼]

Le rôle central des responsables des services d’éducation et d’accueil des jeunes enfants (EAJE) pour le développement d’une qualité de services est souligné dans de nombreux rapports internationaux. Citons notamment les travaux de l’OCDE . Pourtant, selon les contextes, les contours de ce rôle ne sont pas toujours clairement établis ; ils peuvent être source de confusion et d’ambiguïté. La difficulté de gérer les services en conciliant des fonctions sociales, éducatives et économiques est clairement posée. La difficulté également de gérer une équipe dont les membres ont des statuts parfois précaires, des niveaux de formation disparates dans un cadre budgétaire restreint. Dans ce contexte comment relever le défi d’élaborer et de développer une dynamique de projet éducatif concerté dans tous les services qu’ils soient en collectivité ou à domicile, en milieu urbain ou rural ? Ce problème est clairement posé en Belgique francophone où aucune formation spécifique à l’enfance de niveau supérieur n’est organisée, où aucune expérience utile aux fonctions de direction n’est exigée à ce jour. Une recherche en voie de finalisation (juin 2015) visant à mieux définir les compétences nécessaires aux fonctions d’accueil et d’encadrement des services à l’enfance a permis d’associer une série d’acteurs de l’enfance, de l’enseignement, de la formation et de responsables politico-administratifs. Dans une démarche de recherche-action, il s’est agi de se décentrer des réalités de la Belgique francophone pour comprendre comment les questions se posent aussi dans d’autres contextes européens (France, Flandre, Angleterre, Suède) et ensuite, de prendre des décisions relatives à la redéfinition des référentiels métiers et de formation, à la révision des textes réglementaires pour les services. Tout en évitant de donner des directives universelles qui nieraient les spécificités de contexte, l'étude propose de relever une série de questions clés relatives aux fonctions de direction, de points de vigilances à relever ainsi que des idées retenues comme essentielles pour l’avenir. [less ▲]

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See detailLes pratiques d’écriture comme stratégies ? Débat(s), usage(s) & méthodologie(s) autour d’un concept
Daubercies, Laurence ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2015), 16(8),

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See detailNIK promotes tissue destruction independently of the alternative NF-kappaB pathway through TNFR1/RIP1-induced apoptosis.
Boutaffala, L.; Bertrand, M. J. M.; Remouchamps, Caroline ULg et al

in Cell death and differentiation (2015)

NF-kappaB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-kappaB2 processing into p52, a process defined as the alternative, or non-canonical, NF-kappaB pathway. Here we reveal an ... [more ▼]

NF-kappaB-inducing kinase (NIK) is well-known for its role in promoting p100/NF-kappaB2 processing into p52, a process defined as the alternative, or non-canonical, NF-kappaB pathway. Here we reveal an unexpected new role of NIK in TNFR1-mediated RIP1-dependent apoptosis, a consequence of TNFR1 activation observed in c-IAP1/2-depleted conditions. We show that NIK stabilization, obtained by activation of the non-death TNFRs Fn14 or LTbetaR, is required for TNFalpha-mediated apoptosis. These apoptotic stimuli trigger the depletion of c-IAP1/2, the phosphorylation of RIP1 and the RIP1 kinase-dependent assembly of the RIP1/FADD/caspase-8 complex. In the absence of NIK, the phosphorylation of RIP1 and the formation of RIP1/FADD/caspase-8 complex are compromised while c-IAP1/2 depletion is unaffected. In vitro kinase assays revealed that recombinant RIP1 is a bona fide substrate of NIK. In vivo, we demonstrated the requirement of NIK pro-death function, but not the processing of its substrate p100 into p52, in a mouse model of TNFR1/LTbetaR-induced thymus involution. In addition, we also highlight a role for NIK in hepatocyte apoptosis in a mouse model of virus-induced TNFR1/RIP1-dependent liver damage. We conclude that NIK not only contributes to lymphoid organogenesis, inflammation and cell survival but also to TNFR1/RIP1-dependent cell death independently of the alternative NF-kappaB pathway.Cell Death and Differentiation advance online publication, 5 June 2015; doi:10.1038/cdd.2015.69. [less ▲]

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See detailInsulinosensibilisateurs (metformine/glitazones) : niveau de preuve et controverse
SCHEEN, André ULg

in Médecine des Maladies Métaboliques (2015), 9

Summary Because of the deleterious role attributed to insulin resistance, insulin sensitizing agents should theoretically reduce the incidence of cardiovascular complications in type 2 diabetes. In the ... [more ▼]

Summary Because of the deleterious role attributed to insulin resistance, insulin sensitizing agents should theoretically reduce the incidence of cardiovascular complications in type 2 diabetes. In the UKPDS, metformin reduced the risk of myocardial infarction and cardiovascular mortality in a rather small group of recently diagnosed patients at a low cardiovascular risk. These results deserve confirmation in a larger study with patients a high cardiovascular risk. Glitazones, as more specific insulin sensitizers, raised much hope. However, rosiglitazone fell from its pedestal after the suspicion of an increased risk of myocardial infarction. In PROactive among patients at high cardiovascular risk, pioglitazone gave positive but questionable results: statistical significance was not reached regarding the large composite primary endpoint, but well regarding the prespecified more focused principal secondary endpoint or in various post-hoc analyses. Thus, even if data with insulin sensitizers appear globally rather promising, evidence is rather weak, therefore leading to recurrent controversy. [less ▲]

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See detailMesures de la voix en contexte écologique et techniques de biofeedback
Remacle, Angélique ULg; Morsomme, Dominique ULg

in Rééducation Orthophonique (2015), 264

Observer, analyser et améliorer la voix des patients dysphoniques dans leur quotidien relève-t-il encore de l’utopie? La dosimétrie ou accumulation vocale est une technique visant à quantifier la voix en ... [more ▼]

Observer, analyser et améliorer la voix des patients dysphoniques dans leur quotidien relève-t-il encore de l’utopie? La dosimétrie ou accumulation vocale est une technique visant à quantifier la voix en contexte écologique. Elle a d’abord fait l’apanage des laboratoires de recherche. Ensuite, publication après publication, les chercheurs ont mis en avant ses atouts et ses limites. Les dispositifs se sont modernisés, leur commercialisation a vu le jour il y a une dizaine d’années et leur utilisation est de plus en plus conviviale. Le biofeedback a été intégré à certains dosimètres. Cette option permet d’aller au-delà de la simple récolte d’informations sur l’usage vocal des patients. Elle peut, par exemple, avertir le sujet d’un comportement vocal inadéquat en temps réel, le but étant qu’il acquiert le bon geste vocal et l’intègre de manière automatique dans son quotidien. Ces outils participent donc aux quatre étapes de la thérapie, à savoir la conscientisation du dysfonctionnement, l’automatisation du geste vocal adéquat, son transfert, et son maintien dans le temps. [less ▲]

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See detailMethodology manual for European Association for Cardio-Thoracic Surgery (EACTS) clinical guidelines.
Sousa-Uva, Miguel; Head, Stuart J.; Thielmann, Matthias et al

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2015), 48(6), 809-16

The goal of all clinical guidelines is to assist patients and practitioners in making healthcare decisions. However, clinical guidelines have been questioned about their quality, transparency and ... [more ▼]

The goal of all clinical guidelines is to assist patients and practitioners in making healthcare decisions. However, clinical guidelines have been questioned about their quality, transparency and independence. Based on the revision of manuals by other scientific cardiothoracic organizations, this document provides instructions for the development of European Association for Cardio-Thoracic Surgery (EACTS) clinical guidelines and other types of evidence-based documents. Four key areas have been addressed: (i) selection of taskforce members and transparency of relations with the industry, (ii) methods for critical appraisal of medical evidence, (iii) rules for writing recommendations and (iv) review process. It is hoped that, by adopting this methodology, clinical guidelines produced by the EACTS will be well balanced, objective and, importantly, trusted by physicians and patients who benefit from their implementation. [less ▲]

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See detailVan botscan tot bodysuit. Naar een maatschappelijk debat over sportinnovatie
Van Oudheusden, Michiel ULg; Van Hoyweghen, Ine

in Karakter. Tijdschrift van wetenschap (2015), 52

Many scientists, athletes, sports bodies, and governments applaud the increasing integration of science and technology into sports. However, the scientization of sports raises ethical, legal, and social ... [more ▼]

Many scientists, athletes, sports bodies, and governments applaud the increasing integration of science and technology into sports. However, the scientization of sports raises ethical, legal, and social issues (ELSI), e.g. about the changing relationship between medical support and human enhancement, and the implications of scientific talent screening in sports for sports participation. A public debate is needed that identifies the ELSI in sports innovation and urges technology innovators, regulators, and decision makers to take into account such issues before sports innovations are irrevocably locked into sports and society. [less ▲]

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See detailThe effect of 8 or 5 years of denosumab treatment in postmenopausal women with osteoporosis: results from the FREEDOM Extension study.
PAPAPOULOS, S.; LIPPUNER, K.; ROUX, C. et al

in Osteoporosis International (2015), 26(12), 2773-2783

Summary: The FREEDOM study and its Extension provide long-term information about the effects of denosumab for the treatment of postmenopausal osteoporosis. Treatment for up to 8 years was associated with ... [more ▼]

Summary: The FREEDOM study and its Extension provide long-term information about the effects of denosumab for the treatment of postmenopausal osteoporosis. Treatment for up to 8 years was associated with persistent reduction of bone turnover, continued increases in bone mineral density, low fracture incidence, and a favorable benefit/risk profile. Introduction: This study aims to report the results through year 5 of the FREEDOM Extension study, representing up to 8 years of continued denosumab treatment in postmenopausal women with osteoporosis. Methods : Women who completed the 3-year FREEDOM study were eligible to enter the 7-year open-label FREEDOM Extension in which all participants are scheduled to receive denosumab, since placebo assignment was discontinued for ethical reasons. A total of 4550 women enrolled in the Extension (2343 long-term; 2207 cross-over). In this analysis, women in the long-term and cross-over groups received denosumab for up to 8 and 5 years, respectively. Results Throughout the Extension, sustained reduction of bone turnover markers (BTMs) was observed in both groups. In the long-term group, mean bone mineral density (BMD) continued to increase significantly at each time point measured, for cumulative 8-year gains of 18.4 and 8.3 % at the lumbar spine and total hip, respectively. In the cross-over group, mean BMD increased significantly from the Extension baseline for 5-year cumulative gains of 13.1 and 6.2 % at the lumbar spine and total hip, respectively. The yearly incidence of new vertebral and nonvertebral fractures remained low in both groups. The incidence of adverse and serious adverse events did not increase over time. Through Extension year 5, eight events of osteonecrosis of the jaw and two events of atypical femoral fracture were confirmed. [less ▲]

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See detailPréfixes & suffixes de l’humain : entre fiction & philosophie
Guesse, Carole ULg

in Acta Fabula : Revue des Parutions en Théorie Littéraire (2015), 16(8),

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See detailRevue épidémiologique des tendinopathies les plus fréquentes
Sancerne, Audrey; Kaux, Jean-François ULg

in Journal de Traumatologie du Sport (2015), 32(4), 223-228

Tendinopathies are overused pathologies essentially present among sportsmen as well as workers. They represent 19 % of musculo-skeletaldisorders, more than 30 % the consultations of general and sports ... [more ▼]

Tendinopathies are overused pathologies essentially present among sportsmen as well as workers. They represent 19 % of musculo-skeletaldisorders, more than 30 % the consultations of general and sports medicine on musculoskeletal system. At present, general epidemiology studiesare few. Data will therefore be included for each tendinopathy: rotator cuff tendinopathies, epicondylitis, trochanteric pain syndrome, patellar andcalcaneal tendinopathies and plantar fasciitis. The articles have been searched on the databases PubMed and Pedro. [less ▲]

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See detailUpdated checklist of the mosquitoes (Diptera: Culicidae) of Belgium
Boukraa, Slimane ULg; Dekoninck, Wouter; Versteirt, Veerle et al

in Journal of Vector Ecology : Journal of the Society for Vector Ecology (2015), 40(2), 398-407

Most information about the systematics and bioecology of Belgian mosquitoes dates back from before 1950, and only scattered information was produced during the last decades. In this paper we review and ... [more ▼]

Most information about the systematics and bioecology of Belgian mosquitoes dates back from before 1950, and only scattered information was produced during the last decades. In this paper we review and update the list of mosquito species recorded in Belgium, from first report (1908) to 2015. Six genera and 31 species were recorded so far, including 28 autochthonous species and three invasive alien species recently recorded in Belgium: Aedes albopictus (Skuse 1894), Ae. japonicus japonicus (Theobald 1901), and Ae. koreicus (Edwards 1917). The six genera are Anopheles (five species), Aedes (sixteen species), Coquillettidia (one species), Culex (four species), Culiseta (four species), and Orthopodomyia (one species). [less ▲]

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See detailExploring the bacterial diversity of Belgian steak tartare using metagenetics and qPCR analysis
Delhalle, Laurent ULg; Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg et al

in Journal of Food Protection (2015), 79(2), 200-229

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to ... [more ▼]

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to bacterial spoilage. The objective of this study was to explore the bacterial flora diversity in steak tartare in Belgium according to the source and to determine which bacteria are able to grow during the shelf life. A total of 58 samples from butchers’ shops, restaurants, sandwich shops and supermarkets were collected. These samples were analyzed using 16S rDNA metagenetics, a classical microbiological technique, and quantitative real-time PCR (qPCR) targeting the Lactobacillus genus. Samples were analyzed at the beginning and at the end of their shelf life, except for those from restaurants and sandwich shops analyzed only at the purchase date. Metagenetic analysis identified up to 180 bacterial species and 90 genera in some samples. But only seven bacterial species were predominant in the samples, depending on the source: Brochothrix thermosphacta, Lactobacillus algidus, Lactococcus piscium, Leuconostoc gelidum, Photobacterium kishitani, Pseudomonas spp. and Xanthomonas oryzae. With this work, an alternative method is proposed to evaluate the total flora in food samples based on the number of reads from metagenetic analysis and the results of qPCR. The degree of underestimation of aerobic plate counts (APCs) at 30°C estimated with the classical microbiology method was demonstrated in comparison with the proposed culture independent method. Compared to culture-based methods, metagenetic analysis combined with qPCR targeting Lactobacillus provides valuable information for characterizing the bacterial flora of raw meat. [less ▲]

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See detailLa vie littéraire au kaléidoscope des Physiologies
Stienon, Valérie ULg

in Site de la Société des Études romantiques et dix-neuviémistes (SERD) (2015)

En mots et en vignettes, la Physiologie littéraire de la monarchie de Juillet élabore ses propres modalités de mise en fiction de la société. Selon un point de vue à la fois avisé et distancié, induit par ... [more ▼]

En mots et en vignettes, la Physiologie littéraire de la monarchie de Juillet élabore ses propres modalités de mise en fiction de la société. Selon un point de vue à la fois avisé et distancié, induit par l’association d’une centralité culturelle parisienne et d’une faible légitimité à l’ombre de la grande littérature, ces petites monographies réorganisent le système des valeurs à travers lesquelles est perçu le fait littéraire à leur époque. C’est l’occasion d’investiguer sur les à-côtés de la littérature, en interrogeant les manières de circonscrire le territoire des lettres et de le faire interagir avec d’autres domaines d’activités. Deux questions font plus particulièrement l’objet de cet article. D'une part, ces textes livrent-ils un traitement englobant et univoque du profil de l’homme de lettres ou s’attachent-ils au contraire à en souligner les nuances et les singularités en multipliant ses variétés, autour de la dichotomie bien connue des figures archétypales du poète et du journaliste ? D'autre part, dans quelle mesure ces textes reconduisent-ils le mythe du génie créateur et les valeurs romantiques du talent et de l’inspiration, compte tenu du fait que celles-ci sont difficilement compatibles avec les stratégies du parvenu et les expédients du jeune auteur pressé d’arriver, ruses que les Physiologies s’appliquent à débusquer, dans la foulée d’une abondante thématisation du macairisme et des fourberies du floueur ? [less ▲]

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See detailSemantic Web and the Future of Health Care Data in Family Practice
Jamoulle, Marc ULg; Vander Stichele, Robert H; Cardillo, Elena et al

in Merit Research Journal of Medicine and Medical Sciences (2015), 3(12), 586-594

Abstract New tools in data management have emerged in the last decade, which are going to revolutionize electronic health records and health information systems. Family practitioners are the first, main ... [more ▼]

Abstract New tools in data management have emerged in the last decade, which are going to revolutionize electronic health records and health information systems. Family practitioners are the first, main and continuous contact with the patient. They are the source and endpoint of the circle of information, generated by judicious medical documentation and smart secondary use of medical data. This article is an introduction to health terminologies, ontologies, semantic data, and linked open data, all expressions used by computer scientists, preparing themselves for the next step: semantic web for health care data [less ▲]

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See detailQuantum manifestations of classical nonlinear resonances
Wisniacki, Diego A.; Schlagheck, Peter ULg

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2015), 92

When an integrable classical system is perturbed, nonlinear resonances are born, grow, and eventually disappear due to chaos. In this paper the quantum manifestations of such a transition are studied in ... [more ▼]

When an integrable classical system is perturbed, nonlinear resonances are born, grow, and eventually disappear due to chaos. In this paper the quantum manifestations of such a transition are studied in the standard map. We show that nonlinear resonances act as a perturbation that break eigenphase degeneracies for unperturbed states with quantum numbers that differ in a multiple of the order of the resonance. We show that the eigenphase splittings are well described by a semiclassical expression based on an integrable approximation of the Hamiltonian in the vicinity of the resonance. The morphology in phase space of these states is also studied. We show that the nonlinear resonance imprints a systematic influence in their localization properties [less ▲]

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See detailBroadening, Deepening, and Governing Innovation: Flemish Technology Assessment in Historical and Socio-Political Perspective
Van Oudheusden, Michiel ULg; Charlier, Nathan ULg; Rosskamp, Benedikt ULg et al

in Research Policy (2015), 44(10), 1877-1886

This article examines how science, technology, and innovation (STI) policies in Flanders (Belgium) are affected by, and potentially transformed through, technology assessments (TAs). Broadly defined, TAs ... [more ▼]

This article examines how science, technology, and innovation (STI) policies in Flanders (Belgium) are affected by, and potentially transformed through, technology assessments (TAs). Broadly defined, TAs encompass activities and programs that expand and deepen the knowledge base of contemporary knowledge-based economies (KBEs), typically by including new actors (e.g. trade unions), ideas (e.g. science in society), and rationales (e.g. participatory techniques) in STI processes. Starting from the regionalization of STI policy in Belgium and the convergence of Flemish STI around global KBE principles, the article exemplifies how since the 1980s successive Flemish TA waves (early- warning, bottom-up, and interactive TA) have co-evolved with successive generations of Flemish innovation policy. Building on these findings, it argues that Flemish TA has assumed the role of mediator between science and society, both by counteracting and accommodating dominant STI paradigms. By providing a historical and socio-political perspective on TA and innovation policy, the article draws critical attention to the institutional settings and societal contexts in which TA is embedded, and questions TA's strategic utility within contemporary KBEs. This perspective sheds light on the Flemish government's recent decision to close its parliamentary TA institute and the institutional expansion of TA elsewhere in Europe. [less ▲]

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See detailA metagenomic approach from aphid’s hemolymph sheds light on the potential roles of co-existing endosymbionts
De Clerck, Caroline ULg; Fujiwara, Akiko; Joncour, Pauline et al

in Microbiome (2015), 3(63),

Background: Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory ... [more ▼]

Background: Aphids are known to live in symbiosis with specific bacteria, called endosymbionts which can be classified as obligate or accessory. Buchnera aphidicola is generally the only obligatory symbiont present in aphids, supplying essential nutrients that are missing in the plants phloem to its host. Pentalonia nigronervosa is the main vector of the banana bunchy top virus, one of the most damageable viruses in banana. This aphid is carrying two symbionts: B. aphidicola (BPn) and Wolbachia sp. (wPn). The high occurrence of Wolbachia in the banana aphid raises questions about the role it plays in this insect. The goal of this study was to go further in the understanding of the role played by the two symbionts in P. nigronervosa. To do so, microinjection tests were made to see the effect of wPn elimination on the host, and then, high-throughput sequencing of the haemolymph was used to analyze the gene content of the symbionts. Results: We observed that the elimination of wPn systematically led to the death of aphids, suggesting that the bacterium could play a mutualistic role. In addition, we identify and annotate 587 and 250 genes for wPn and BPn, respectively, through high-throughput sequencing. Analysis of these genes suggests that the two bacteria are working together for the production of several essential nutrients. The most striking cases are for lysin and riboflavin which are usually provided by B. aphidicola alone to the host. In the banana aphid, the genes involved in the production pathways of these metabolites are shared between the two bacteria making them both essential for the survival of the aphid host. Conclusions: Our results suggest that a co-obligatory symbiosis between B. aphidicola and Wolbachia occurs in the banana aphid, the two bacteria acting together to supply essential nutrients to the host. This is, to our knowledge, the first time Wolbachia is reported to play an essential role in aphids. [less ▲]

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See detailSarcopenia as a public health problem
Bruyère, Olivier ULg; Beaudart, Charlotte ULg; Locquet, Médéa ULg et al

in European Geriatric Medicine (2015)

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an ... [more ▼]

The importance of a health problem is based on its current and expected prevalence, its clinical and economic consequences, the social status of people affected by the problem and the availability of an effective treatment. In this paper, we review the main current literature on sarcopenia in order to assess whether this geriatric syndrome could be considered as a major public health problem. Our review highlights that based on its prevalence, its clinical consequences, the limitations of the current available treatments as well as on the fact that many frail patients are affected by this geriatric syndrome, sarcopenia should be considered as a health priority by all interested parties in order to reduce its burden. [less ▲]

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See detailAn overview of potamodromous fish upstream movements in medium-sized rivers, by means of fish passes monitoring
Benitez, Jean-Philippe ULg; Nzau Matondo, Billy ULg; Dierckx, Arnaud ULg et al

in Aquatic Ecology (2015), 49(4), 481-497

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the ... [more ▼]

This study aims to investigate the upstream movement patterns of potamodromous fish species using multi-annual monitoring of modern multi-species fish passes in two medium-sized Belgian rivers: the Berwinne and the Amble`ve. During a 6-year monitoring period including a frequency of 1–5 times per week, the captured individuals were identified, measured and weighed to determine species abundance, and the periodicity of their seasonal movement patterns was investigated in relation to environmental factors. In the Amble`ve, 22 different fish species were monitored (n = 1513 individuals; biomass of 154 kg) and 14 species in the Berwinne (n = 3720; 408 kg). In both fish passes, inter-annual differences were observed, but the first year of monitoring was the best in terms of biomass, indicating the existence of an opening effect just after the fish passes opening, which allowed new migration routes. Salmonids and rheophilic cyprinids were predominant in terms of biomass, while minnow and spirlin were predominant in terms of number of fishes. The diversity in sizeranged from 46 to 760 mm demonstrating the importance of movements in various life stages. The capture periodicity showed different mobility patterns between the adult and juvenile stages in most species. Movements occurred frequently during the circus reproduction period for some species, but many species moved also apart from spawning period. This study highlights the omnipresence of patrimonial holobiotic potamodromous fish at different life stages that reflect their biological needs to move throughout the annual cycle. They must be considered as target species in river continuity restoration programmes and fish-pass design. [less ▲]

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