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See detailVascular calcification: from pathophysiology to biomarkers
EVRARD, Séverine ULg; DELANAYE, Pierre ULg; Kamel, S et al

in Clinica Chimica Acta (2015), 438

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have ... [more ▼]

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlightedmore and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood,many questions still remain unanswered. This reviewbriefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed. [less ▲]

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See detailOptimal propellantless rendez-vous using differential drag
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Acta Astronautica (2015), 109

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us ... [more ▼]

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us to turn the often-undesired drag perturbation into a control force for relative motion, differential drag is among the most promising propellantless techniques for low-Earth orbiting satellites. An optimal control approach to the problem of orbital rendez-vous using differential drag is proposed in this paper. Thanks to the scheduling of a reference maneuver by means of a direct transcription, the method is flexible in terms of cost function and can easily account for constraints of various nature. Considerations on the practical realization of differential-drag-based maneuvers are also provided. The developments are illustrated by means of high-fidelity simulations including coupled 6-degree-of-freedom simulations and an advanced aerodynamic model. [less ▲]

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (2015), 55(1), 73-91

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailEvolution de la chalarose du frêne en Wallonie
Gerarts, Fanny ULg; Chandelier, Anne; Claessens, Hugues ULg et al

in Forêt Wallonne (2015), 134

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See detail“Rhizoponics”: a novel hydroponic rhizotron for root system analyses on mature Arabidopsis thaliana plants
Mathieu, Laura ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

in Plant Methods (2015), 11

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to ... [more ▼]

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to adult stages, i.e. from seed to seed. This system offers the advantages of hydroponics such as control of root environment and easy access to the roots for measurements or sampling. Being completely movable and low cost, it can be used in controlled cabinets. We chose the case of cadmium treatment to illustrate potential applications, from cell to organ levels. [less ▲]

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See detailEffect of stress path on the miniaturization size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Habraken, Anne ULg et al

in International Journal of Plasticity (2015), 64

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. The objective of this work is to provide new experimental results in order to analyze the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensile tests, large tensile tests and shear tests have been performed on Ni sheets with various grain sizes. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanical softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. From an industrial point of view, it is hence possible to improve the forming of microparts using suitable stress paths. [less ▲]

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See detailConstruire des savoirs sur l'activité de lecture afin de développer les compétences des élèves en difficulté : l'inaccessible rêve?
De Croix, Séverine ULg; Ledur, Dominique

in Education & Formation (2015), e-302

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La ... [more ▼]

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La réflexion qui suit s’inscrit dans le cadre des travaux relatifs aux enseignements adaptés à la prise en charge de ces déficits. Des dispositifs visant à développer la métacognition en lecture, à construire des savoirs sur cette activité et à mieux se percevoir en tant que lecteur ont été conçus, expérimentés et analysés dans le cadre d’une recherche-action longitudinale de type qualitatif. Cet article décrit quelques effets de ces dispositifs, qui encouragent à poursuivre sur la voie de ces interventions à dimension métacognitive dans des recherches à plus large échelle. [less ▲]

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See detailThe Reputation Effect: A Case Study of Credit Contracts in Transition Countries
Artige, Lionel ULg; Nicolini, Rosella

in International Journal of Finance and Banking Studies (2015), 4(1), 1-17

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See detailN1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase
Henrottin, Jean ULg; Zervosen, Astrid ULg; Lemaire, Christian ULg et al

in ACS Medicinal Chemistry Letters (2015)

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive ... [more ▼]

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive properties in inflammatory and tumoral tissues. The syntheses of 1-(2-fluoroethyl)-tryptophan (1-FETrp) and 1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-tryptophan, two N1-fluoroalkylated tryptophan derivatives, are described here. In vitro enzymatic assays with these two new potential substrates of hIDO show that 1-FETrp is a good and specific substrate of hIDO. Therefore, its radioactive isotopomer, 1-[18F]FETrp, should be a molecule of choice to visualize tumoral and inflammatory tissues and/or to validate new potential inhibitors. [less ▲]

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See detail"Lire le rythme". Henri Meschonnics Theorie und Praxis des Lesens
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), 41-60

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See detailInstitutional Investors, adverse selection and stock market liquidity in France
Sougné, Danielle ULg; Aymen, Ajina; Faten, Lakhal

in International Journal of Managerial Finance (2015), 11

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of ... [more ▼]

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of institutional investors has a positive and significant effect on stock-market liquidity, which confirms the signal theory and trading hypothesis. These investors perform high trading activity which favorably affects market liquidity. The results also show that pension funds improve liquidity. This result suggests that pension funds manage huge assets decreasing transactions costs and improving liquidity. They display a positive signal to the market about more transparency and a low level of information asymmetry. [less ▲]

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailCamorra in Montesacro. Urban and social transformation in a southern Italian community
De Biase, Marco ULg

in ECPR Standing Group on Organised Crime (2015), 12(1), 8-10

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See detailCompte-rendu de l'ouvrage d'Eva Illouz : "Hard Romance : "Cinquante nuances de Grey" et nous" (2014)
Ledent, David ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2015)

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See detailPrise en charge d'un cancer du sein chez une femme porteuse de prothèses mammaires
REMACLE, Sarah; LIFRANGE, Eric ULg; NIZET, Jean-Luc ULg

in Revue Médicale de Liège (2015), 70

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning ... [more ▼]

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning the risk of inducing breast cancer or delaying the diagnosis, however, no significant causal relationship has been established. The purpose of this article is to assess the diagnostic and therapeutic consequences when breast cancer is identified in a patient with breast implants. [less ▲]

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See detailSEM and EDS observations of carrollite bioleaching with a mixed culture of acidophilic bacteria
Nkulu, Guy; Gaydardzhiev, Stoyan ULg; Mwema, Edouard et al

in Minerals Engineering (2015), doi:10.1016/j.mineng.2014.12.005

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to ... [more ▼]

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to provide evidence of the interaction pattern between carrollite and microorganisms. A bacterial consortium involving three different acidophilic chemolithotrophs was adopted. The evolution of the surface topography, inside alteration effects and elemental composition of the mineral with leaching time was followed. It could be postulated that bacterial adhesion takes place on the mineral surface, resulting in the formation of dissolution pits of various shapes and continues by boring elongated channels deep inside the mineral grains. Enhanced concentration of ferric iron and sulphur could be assumed in vicinity of the zones where mineralized polymer substances are precipitated. It could be inferred that carrollite dissolution is governed by cooperative bioleaching involving oxidation induced by bacteria attached to the surface and ferric iron re-oxidized by planktonic bacteria in suspension. [less ▲]

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See detailIn situ bidentate to tetradentate ligand exchange reaction in cobalt-mediated radical polymerization
Kermagoret, Anthony ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

in European Polymer Journal (2015), 62

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this, none of the reported complexes offers optimal control for monomers with very different reactivity, which somewhat limits the synthesis of copolymers. In order to expand the scope of cobalt-mediated radical polymerization (CMRP), we investigated an in situ ligand exchange reaction for modulating the properties of the cobalt complex at the polymer chain-end and adjusting the C-Co bond strength involved in the control process. With the aim of improving the synthesis of poly(vinyl acetate)-b-poly(n-butyl acrylate) copolymers, bidentate acetylacetonate ligands, which impart high level of control to the polymerization of vinyl acetate (VAc), were replaced in situ at the PVAc-cobalt chain-end by tetradentate Salen type ligands that are more suited to acrylates. [less ▲]

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See detailGuaranteed Conditional Performance of the S2 Control Chart with Estimated Parameters
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Woodall, William

in International Journal of Production Research (2015)

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to ... [more ▼]

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to have confidence that the in-control average run length (ARL) obtained will be near the desired value. To overcome this problem, we adjust the S2 chart controls limits such that the in-control ARL is guaranteed to be above a specified value with a certain specified probability. The required adjustment does not have too much of an effect on the out-of-control performance of the chart. [less ▲]

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See detailStimuli-responsive behavior of micelles prepared from a poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer
Poggi, Elio; Guerlain, Claire; Debuigne, Antoine ULg et al

in European Polymer Journal (2015), 62

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4 ... [more ▼]

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4-vinylpyridine) precursor (PVAc-b-PAN-b-P4VP) synthesized by a combination of cobalt-mediated radical polymerization (CMRP) and nitroxide mediated polymerization (NMP). The PVOH-b-PAA-b-P4VP terpolymer is further micellized in water and the accordingly obtained micellar structures are characterized by a combination of dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM) as a function of pH. Well-defined micelles are observed in the whole pH range except for pH values below 4.5 where non-aggregated chains (unimers) are present. The formation of micelles can be rationalized by the formation of insoluble PAA/P4VP inter-polyelectrolyte complexes in the 4.5–6 pH range while hydrophobic P4VP cores are observed at pH values above 6. Finally, the effect of the addition of different salts on the micellar characteristic features is investigated. [less ▲]

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See detailLa France et le Congo ex-belge (1961-1965). Intérêts et influences en mutation
Genin, Vincent ULg

in Revue Belge de Philologie et d'Histoire (2015), 91(2013/4), 1057-1110

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective ... [more ▼]

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective. Ostracized by the United Nations in the summer of 1960 in the context of the Congolese crisis, Belgium has, however, been able to count on the support of France, itself immobilized by the Algerian case. Based on unpublished archives, it seems instructive to study the evolution of the Franco-Belgian relations, in terms of Central African Affairs from 1961 to 1965. France, the overseas influence policy is a fundamental factor, she will devote as much energy to develop and defend its interests in Congo former Belgian (on which she claimed in Brussels its preemptive right, dating back to 1884, spring 1960) as former territories of the French Community? What are the forms, the protagonists and channels (formal and informal) of this influence; how is she fits the postcolonial context and she has an impact on Franco-Belgian relations ? [less ▲]

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See detailRhoGTPases as Key players in mammalian cell adaptation to microgravity.
Louis, Fiona; Deroanne, Christophe ULg; Nusgens-Richelle, Betty ULg et al

in BioMed Research International (2015)

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See detailImpact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability
Frère, Antoine ULg; Kawalec, Michal; Tempelaar, Sarah et al

in Biomacromolecules (2015)

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or ... [more ▼]

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or morpholino functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups), of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5 was evaluated. The use of one of these polymers combining morpholine and guanidine functions at the ratio >1 and hydrophobic trimethylene carbonate groups showed a significant decrease of mRNA and protein level in HeLa cells, similar to PEI. These results highlight the potential of polycarbonate vectors for future in vivo application as an anti-cancer therapy. [less ▲]

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See detailBiochemical characterisation of the seed oils of four safflower (Carthamus tinctorius) varieties grown in north-eastern of Morocco
Ben Moumen, Abdessamad; Mansouri, Farid; Richard, Gaetan ULg et al

in International Journal of Food Science & Technology (2015)

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi ... [more ▼]

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi-arid region of eastern Morocco) was evaluated through analysis of their phenolic and carotenoid contents. The composition of the phenolic compounds of safflower oil has not yet been documented. Therefore, in this preliminary study, Thirty different phenolic compounds were identified, and significant differences between the oil varieties were observed (P < 0.05). In the seed oil from the Rancho and Sharda safflower varieties, the main phenolic compound was trans-chalcone, representing 13.45% and 11.8%, respectively, of the total phenolics, whereas in Cartamar and Cartafri oils, naringin accounted for 26.82% and 16.5%, respectively, of the total phenolics. The total carotenoid contents ranged from 1.13 mg/kg (Rancho) to 1.34 mg/kg (Cartamar and Cartafri).We observed that b-cryptoxanthin (0.31–0.37 mg/kg) and b-carotene (0.3–0.35 mg/kg) were the predominant carotenoids in all of the safflower oils that were studied. [less ▲]

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See detailA simulation study comparing multiple imputation methods for incomplete longitudinal ordinal data
Donneau, Anne-Françoise ULg; Mauer, Murielle; Molenberghs, Geert et al

in Communications in Statistics : Simulation & Computation (2015), 44(5), 1311-1338

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See detailRéinventer le rythme / Den Rhythmus neu denken
Viehöver, Vera ULg; Dupont, Bruno

in Intervalles (2015), 7(2015), 170

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See detail18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneite and Functional Tumor Volume in a Multi-Cancer Site Patient Cohort
HATT, MAT; MAJDOUB, MOHAMED; VALLIERES, MARTIN et al

in Journal of Nuclear Medicine (The) (2015), 56(1), 38-44

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See detailNghiên cứu và thiết kế hai kiểu chuồng nuôi nhông cát Leiolepis guttata (Cuvier, 1829) phù hợp với điều kiện nuôi và vốn đầu tư tại huyện Bắc Bình, tỉnh Bình Thuận
Tran, Tinh ULg; Tran, Ngoc Nguyen Kim Dieu; Vo, Kim Thong et al

in Journal of Agriculture Sciences and Technology (2015), 1/2014

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan ... [more ▼]

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan province) is considered as a fortuitous discovery which was the initiator of the current expanding trend of its rearing. Because L. guttata is a wild animal, with strong disease resistance and adaptation capacity, livestock farmers are presently not very interested in important aspects: rearing techniques, enclosure’s types, sex ratio, diseases’ prevention, etc. Notably the building of enclosures not perfectly suitable breeds a noticeable loss of the number of lizards and a reduction in the profits for the farmers. To this end, the building of two types of enclosures adapted to local rearing conditions and the investing capital available in Bac Binh district, Binh Thuan province is presently essential. We descrite two types of enclosure: the first one surrounded by a bricks (or breeze blocks) wall, the second one fended by a fiber cement corrugated sheets wall. Moreover, we suggest to introduce plants in order to build a vegetal cover nearer to the natural environment of L. guttata: shrubs and a plant carpet becoming the preferential refuge area of the spotted butterfly lizard. [less ▲]

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See detailEinleitung
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), -

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See detailA review of gliptins for 2014.
Scheen, André ULg

in Expert opinion on pharmacotherapy (2015), 16(1), 43-62

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a personalized medicine in patients with Type 2 diabetes. Areas covered: An updated review providing an analysis of available recent data with commercialized DPP-4 inhibitors, with a special focus on: differences between the various molecules, novelties regarding their mechanism of action, clinical efficacy in mono- and various combined therapies, comparison with other new therapies, efficacy-safety profile in at risk patients, concern about pancreatic safety, perspectives in cardiovascular prevention and, finally, a selection of remaining unanswered important questions for the clinician. Expert opinion: DPP-4 inhibitors offer various advantages when compared to other glucose-lowering agents. Despite they have been commercialized since a few years only, available data obtained in randomised controlled trials are of better quality compared to those available with ancient classical glucose-lowering agents, especially in more fragile populations such as elderly people, individuals with renal impairment or at high cardiovascular risk and patients at higher risk of hypoglycaemia. However, there remain uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experience combined with a careful post-marketing surveillance. [less ▲]

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See detailSoft power, global governance of cultural industries and rising powers: the case of China
Vlassis, Antonios ULg

in International Journal of Cultural Policy (2015)

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to ... [more ▼]

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to shape the structures of their international environment. More specifically, studying the cases of People’s Republic of China and of the movie industry, my article focuses on the current evolution of the relationship between the Chinese authorities and the film industry, as well as on the development of the domestic film market. I further aim to draw up an inventory of China’s role within the global governance of cultural industries. Finally, I aim to highlight the global cultural competition that China faces, emphasizing the practices of the US administration and Hollywood. I argue that even if China is the current centre of gravity within the world economy, it still has a long way to go in order to shape the distribution of resources within the global governance of cultural industries and to play a crucial role in the international battle of cultural symbols. [less ▲]

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See detailPossibilities for Co(III) dissolution from an oxidized ore through simultaneous bioleaching of pyrite
Zeka, Leon; Lambert, Fanny ULg; Frenay, Jean ULg et al

in Minerals Engineering (2015)

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and ... [more ▼]

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and abiotic experiments at various pulp densities and redox potentials have been performed and results compared. Cobalt leaching at elevated redox potential is possible, offering cost reduction benefits due to reduced consumption of ferrous iron. At elevated potential of 625 mV, however, the initial rate of cobalt leaching has been found as 115 mg/(g ore)⋅(24 h), lower than the rate of 865 mg/(g ore)⋅(24 h) registered at 505 mV. Less stochiometric amount of ferrous iron was required when cobalt leaching was coupled to pyrite bioleaching, with 75% of cobalt recovered for 12 h at the optimally found conditions. It could be inferred that the Fe3+–Fe2+ cycle exists and is efficiently maintained through bacterial presence in the studied system. [less ▲]

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See detailL'évaluation émancipatrice, l'évaluateur et les formes de la communauté
Absil, Gaëtan ULg; Vandoorne, Chantal ULg

in L'Observatoire (2015), 82(Janvier-Février-Mars 2015), 30-35

Cet article explore des enjeux de l’évaluation émancipatrice d’un projet de santé communautaire, d’un programme transfrontalier de promotion de la santé mentale et de projets de promotion de la santé par ... [more ▼]

Cet article explore des enjeux de l’évaluation émancipatrice d’un projet de santé communautaire, d’un programme transfrontalier de promotion de la santé mentale et de projets de promotion de la santé par les services de santé scolaire. Ces enjeux sont questionnés selon les axes politique, opérationnel ou constructiviste de l’évaluation. Le propos porte sur les liens entre l’évaluation émancipatrice et la communauté formée par les stakeholders. Il ouvre une réflexion sur les enjeux micro, méso et macro sociaux de l’évaluation et la posture de l’évaluateur. [less ▲]

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See detailDevelopment and validation of an accelerometer-based method for quantifying gait events
Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg; Stamatakis, Julien et al

in Medical Engineering & Physics (2015)

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO ... [more ▼]

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO), and toe-off (TO), from wireless accelerometers applied to the right and left foot. First, the signals recorded from heel and toe three-axis accelerometers are segmented providing heel and toe flat phases. Then, the four gait events are defined from these flat phases. The accelerometer-based event identification was validated in seven healthy volunteers and a total of 247 trials against reference data provided by a force plate, a kinematic 3D analysis system, and video camera. HS, TS, HO, and TO were detected with a temporal accuracy ± precision of 1.3 ms ± 7.2 ms, ‒4.2 ms ± 10.9 ms, ‒3.7 ms ± 14.5 ms, and ‒1.8 ms ± 11.8 ms, respectively, with the associated 95% confidence intervals ranging from ‒6.3 ms to 2.2 ms. It is concluded that the developed accelerometer-based method can accurately and precisely detect HS, TS, HO, and TO, and could thus be used for the ambulatory monitoring of gait features computed from these events when measured concurrently in both feet. [less ▲]

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See detailEpidemiological Review of Injuries in Rugby Union
Kaux, Jean-François ULg; Julia, Marc; Delvaux, François ULg et al

in Sports (2015), 3(1), 21-29

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This ... [more ▼]

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This epidemiological review of injuries incurred by rugby players mentions the position and type of injuries, the causes, time during the match and season in which they occur and the players’ positions as well as the length of players’ absences following the injury. [less ▲]

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See detailReview of Transnational Migration
Munos, Delphine ULg

in South Asian Diaspora (2015), 7(1), 63-65

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See detailProbiotics: an update
Vandenplas, Yvan; Huys, Geert; Daube, Georges ULg

in Jornal de Pediatria (2015), 1

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent ... [more ▼]

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children. Sources: Relevant literature from searches of PubMed, CINAHL, and recent consensus statements were reviewed. Summary of the findings: While a balanced microbiome is related to health, an imbalanced microbiome or dysbiosis is related to many health problems both within the gastro-intestinal tract, such as diarrhea and inflammatory bowel disease, and outside the gastro-intestinal tract such as obesity and allergy. In this context, a strict regulation of probiotics with health claims is urgent, because the vast majority of these products are commercialized as food (supplements), claiming health benefits that are often not substantiated with clinically relevant evidence. The major indications of probiotics are in the area of the prevention and treatment of gastrointestinal related disorders, but more data has become available on extra-intestinal indications. At least two published randomized controlled trials with the commercialized probiotic product in the claimed indication are a minimal condition before a claim can be sustained. Today, Lactobacillus rhamnosus GG and Saccharomyces boulardii are the best-studied strains. Although adverse effects have sporadically been reported, these probiotics can be considered as safe. Conclusions: Although regulation is improving, more stringent definitions are still required. Evidence of clinical benefit is accumulating, although still missing in many areas. Misuse and use of products that have not been validated constitute potential drawbacks. [less ▲]

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See detailChine, une mise à jour
Florence, Eric ULg

in Politique : Revue de Débats (2015), 88

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois ... [more ▼]

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois. L’argument le plus souvent évoqué était celui d’un décalage insoutenable entre réformes économiques – qui connaîtront un approfondissement à l’occasion du fameux « voyage dans le Sud » de Deng Xiaoping en 1992 – et l’absence de réformes politiques, un décalage qui devait presque immanquablement signifier la fin du régime communiste. Quelque vingt-cinq ans plus tard, où en est-on ? [less ▲]

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See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
FRIPPIAT, Frédéric ULg; Musuamba, FT; Seidel, Laurence ULg et al

in Journal of Antimicrobial Chemotherapy (2015)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean ± SEM: 0.29 ± 0.030 versus 0.20 ± 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

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See detailInfluence of sugar beet pulp on feeding behavior, growth performance, carcass quality and gut health of flattening pigs.
Laitat, Martine ULg; Antoine, Nadine ULg; Cabaraux, Jean-François ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 20-31

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See detailCircadian and circannual variations in cord blood hematopoietic cell composition
Servais, Sophie ULg; BAUDOUX, Etienne ULg; Brichard, B. et al

in Haematologica (2015), 100(1), 32-34

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See detailPurification and identification of novel antioxidant peptides from enzymatic hydrolysate of chickpea (Cicer arietinum L.) protein concentrate
Ghribi, Abir Mokni; Sila, Assaâd; Przybylski, Rémi et al

in Journal of functional foods (2015), 12

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher ... [more ▼]

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher antioxidant activity than CP. This hydrolysate was fractionated by size exclusion chromatography on a Sephadex G-25 into four major fractions (Fra.I, Fra.II, Fra.III, and Fra.IV). Fraction III, which exhibited the highest DPPH scavenging activity (54% at 1 mg/ml), was then fractionated by reversed-phase high performance liquid chromatography (RP-HPLC). Eleven antioxidant fractions were isolated and two peptide subfractions show antioxidant activity (P3 and P8). The P8 displayed the highest DPPH radicalscavenging activity (67%; at 200 g/ml) among these peptides subfractions. The molecular masses and amino acids sequences of the purified peptides were determined using ESIMS and ESIMS/MS, respectively. Their structures were identified as Asp-His-Gly and Val- Gly-Asp-Ile. These peptides did not show haemolytic activity towards bovine erythrocytes. The results suggest that CPH are good source of natural antioxidants. [less ▲]

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See detailThe impact of transport policies on railroad intermodal freight competitiveness – The case of Belgium
Santos, Bruno F.; Limbourg, Sabine ULg; Carreira, Joana Silva

in Transportation Research. Part D : Transport and Environment (2015), 34

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist ... [more ▼]

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist in subsidizing intermodal transport operations (such as in Belgium, to stimulate rail transport), internalizing external costs (as recommended by the European Union in order to foster cleaner modes), and adopting a system perspective when optimizing the location of inland intermodal terminals. The study proposes an innovative mixed integer intermodal freight location-allocation model based on hub-location theory and deals with non-linear transport costs in order to replicate economies of distance. Our analysis suggests that subsidizing has a significant impact on the volumes transported by intermodal transport, and, to a lesser extent, that optimizing terminal location increases the competitiveness of intermodal transport. On the other hand, according to our assumptions, internalizing external costs can negatively impact the promotion of intermodality. This finding indicates that innovative last-mile transports are needed in order to reduce the external impacts of drayage operations. [less ▲]

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See detailInvestigation of the links between mass transfer conditions, dissolved hydrogen concentration and biohydrogen production by the pure strain Clostridium butyricum CWBI1009
Beckers, L.; Masset, J.; Hamilton, C. et al

in Biochemical Engineering Journal (2015), 98

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen ... [more ▼]

Fermentative hydrogen production has often been described as inhibited by its own gas production. In this work, hydrogen production by Clostridium butyricum was investigated in batch Biochemical Hydrogen Potential (BHP) tests and in a 2.5L anaerobic sequenced batch reactor (AnSBR) under different operating conditions regarding liquid-to-gas mass transfer. Through the addition of both stirring up to 400rpm and nitrogen sparging, the yields were enhanced from 1.6 to 3.1molH2molglucose -1 and the maximum hydrogen production rates from 140 to 278mLh-1. These original results were achieved with a pure Clostridium strain. They showed that hydrogen production was improved by a higher liquid-to-gas hydrogen transfer resulting in a lower dissolved hydrogen concentration in the culture medium and therefore in a lower bacterial inhibition. In addition, biohydrogen partitioning between the gas and the liquid phase did not conform to Henry's Law due to critical supersaturation phenomena up to seven-fold higher than the equilibrium conditions. Therefore, dissolved hydrogen concentration should be systematically measured instead of the headspace hydrogen partial pressure. A model was proposed to correlate H2 production yield and rate by the pure C. butyricum strain CWBI1009 with mass transfer coefficient KLa. [less ▲]

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See detailBilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway
Alhosin, Mahmoud; León-González1, Antonio J.; Dandache et al

in Scientific Reports (2015), 5

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an ... [more ▼]

Defect in apoptosis has been implicated as a major cause of resistance to chemotherapy observed in B cell chronic lymphocytic leukaemia (B CLL). This study evaluated the pro-apoptotic effect of an anthocyanin-rich dietary bilberry extract (Antho 50) on B CLL cells from 30 patients and on peripheral blood mononuclear cells (PBMCs) from healthy subjects, and determined the underlying mechanism. Antho 50 induced concentration- and time-dependent pro-apoptotic effects in B CLL cells isolated from patients but little or no effect in PBMCs. Among the main phenolic compounds present in this bilberry extract, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside showed the highest apoptotic effect on B CLL cells, suggesting that anthocyanins play a main role in the cytotoxic activity. Antho 50-induced apoptosis is associated with activation of caspase 3 and down-regulation of the anti-apoptotic protein UHRF1. Antho 50 induced also rapid dephosphorylation of Akt and Bad, and down-regulation of Bcl-2 resulting in reduced cell viability. Antho 50 significantly induced PEG-catalase-sensitive formation of reactive oxygen species in B CLL cells. PEG-catalase prevented the Antho 50-induced reduced cell viability, induction of apoptosis, up-regulation of caspase 3, down-regulation of UHRF1 and Bcl-2, and dephosphorylation of Bad. The present findings indicate that Antho 50 exhibits strong pro-apoptotic activity through redox-sensitive caspase 3 activation-related mechanism in B CLL cells involving dysregulation of Bad/Bcl-2 pathway. This activity is due, at least in part, to a composition rich on glucoside and rutinoside derivatives of delphinidin. They further suggest that Antho 50 has chemotherapeutic potential by targeting selectively B CLL cells. [less ▲]

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See detailFarmers' practices and willingness to adopt supplemental irrigation in Burkina Faso
Zongo, Bétéo ULg; Diarra, Abdoulaye; Barbier, Bruno et al

in International Journal of Food and Agricultural Economics (2015), 3(1), 101-117

This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a ... [more ▼]

This study analyzes farmers' practices and willingness to adopt supplemental irrigation on rainfed crops in the Sahelian and Sudano-Sahelian areas of Burkina Faso. A survey of 629 farmers revealed a diversity of farming practices within and between two agro-climatic zones. Over 65% of farmers believe that supplemental irrigation is a good way to mitigate the adverse effects of dry spells on crop yields. Determining factors of farmers’ willingness to adopt supplemental irrigation were identified using a logistic model. Lack of information is the major obstacle to promoting this innovation. Farmers’ training and information dissemination are the best ways to increase the acceptance of this promising technology. [less ▲]

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See detailInvestigating word recognition in intercomprehension: methods and findings
Möller, Robert ULg; Zeevaert, Ludger ULg

in Linguistics (2015), 53(2), 313352

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See detailShort communication: Novel method to predict body weight of primiparous dairy cows throughout the lactation
Vanrobays, Marie-Laure ULg; Vandenplas, Jérémie ULg; Hammami, Hedi ULg et al

in Journal of Dairy Science (2015), 98

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the ... [more ▼]

Body weight (BW) of dairy cows can be estimated using linear conformation traits (calculated BW; CBW), which are generally recorded only once during a lactation. However, predicted BW (PBW) throughout the lactation would be useful, e.g., at milk-recording dates allowing feed-intake prediction for advisory purposes. Therefore, a 2-step approach was developed to obtain PBW for each milk-recording date. In the first step, a random-regression test-day model was used with CBW as observations to predict PBW. The second step consisted in changing means and (co)variances of prior distributions for the additive genetic random effects of the test-day model by using priors derived from results of the first step to predict again PBW. A total of 25,061 CBW from 24,919 primiparous Holstein cows were computed using equations from literature. Using CBW as observations, PBW was then predicted over the whole lactation for 232,436 dates corresponding to 207,375 milk-recording dates and 25,061 classification dates. Results showed that using both steps (the 2-step approach) provided more accurate predictions than using only the first step (the one-step approach). Based on the results of this preliminary study, BW of dairy cows could be predicted throughout the lactation using this procedure. These predictions could be useful in milk-recording systems to compute traits of interest (e.g., feed-intake prediction). The developed novel method is also flexible because actual direct measurements of BW can also be used together with CBW, the prediction model being able to accommodate different levels of accuracies of used BW phenotypes. [less ▲]

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See detailTyranny of Trees in Global Climate Change Mitigation
Veldman, Joseph W.; Overbeck, Gerhard; Negreiros, Daniel et al

in Science (2015), 347(6221)

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See detailJean-Marie KAJDANSKI, Pain gris, 2014.
Baiwir, Esther ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2015), (1/2015), 13-14

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See detailDramatic osteonecrosis of the jaw associated with oral bisphosphonates, periodontitis and dental implant removal
Ayora, A F; HERION, Francine ULg; ROMPEN, Eric ULg et al

in Journal of Clinical Periodontology (2015), 42

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these ... [more ▼]

Osteoporosis affects millions of elderly patients, and anti-resorptive drugs (ARD) such as bisphosphonates (BP) represent the first-line therapy. Despite the benefits related to the use of these medications, osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. CASE PRESENTATION: This report documents a case of dramatic bisphosphonate-related osteonecrosis associated with periodontitis and dental implant removal in an osteoporotic patient treated with per os bisphosphonates for an uninterrupted period of 15 years. CONCLUSION: The aim of this report was to discuss the administration period of BP in the treatment of osteoporosis, the decision-making and clinical management of severe MRONJ and the indications for dental implant placement in these specific patients. [less ▲]

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See detailThe ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating patterning of prethalamus and ventral telencephalon.
Magnani, D; Morlé, L; Hasenpusch-Theil, K et al

in Human Molecular Genetics (2015)

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of ... [more ▼]

Primary cilia are complex subcellular structures that play key roles during embryogenesis by controlling the cellular response to several signaling pathways. Defects in the function and/or structure of primary cilia underlie a large number of human syndromes collectively referred to as ciliopathies. Often, ciliopathies are associated with mental retardation (MR) and malformation of the corpus callosum. However, the possibility of defects in other forebrain axon tracts, which could contribute to the cognitive disorders of these patients, has not been explored. Here, we investigate the formation of the corticothalamic/thalamocortical tracts in mice mutant for Rfx3, which regulates the expression of many genes involved in ciliogenesis and cilia function. Using DiI axon tracing and immunohistochemistry experiments, we show that some Rfx3-/- corticothalamic axons abnormally migrate toward the pial surface of the ventral telencephalon (VT). Some thalamocortical axons (TCAs) also fail to leave the diencephalon or abnormally project toward the amygdala. Moreover, the Rfx3-/- VT displays heterotopias containing attractive guidance cues and expressing the guidance molecules Slit1 and Netrin1. Finally, the abnormal projection of TCAs toward the amygdala is also present in mice carrying a mutation in the Inpp5e gene, which is mutated in Joubert Syndrome and which controls cilia signaling and stability. The presence of identical thalamocortical malformations in two independent ciliary mutants indicates a novel role for primary cilia in the formation of the corticothalamic/thalamocortical tracts by establishing the correct cellular environment necessary for its development. [less ▲]

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See detailDe Bruxelles I à Bruxelles Ibis - Retouches aux règles de compétence
Boularbah, Hakim ULg

in Journal des Tribunaux (2015)

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See detailBioaccumulation of organohalogenated compounds in sharks and rays from the southeastern USA
Weijs, Liesbeth; Briels, Nathalie; Adams, Douglas et al

in Environmental Research (2015), 137

Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the ... [more ▼]

Organohalogenated compounds are widespread in the marine environment and can be a serious threat to organisms in all levels of aquatic food webs, including elasmobranch species. Information about the concentrations of POPs (persistent organic pollutants) and of MeO-PBDEs (methoxylated polybrominated diphenyl ethers) in elasmobranchs is scarce and potential toxic effects are poorly understood. The aims of the present study were therefore to investigate the occurrence of multiple POP classes (PCBs, PBDEs, DDXs, HCB, CHLs) and of MeO-PBDEs in various elasmobranch species from different trophic levels in estuarine and marine waters of the southeastern United States. Overall, levels and patterns of PCBs, PBDEs, DDXs, HCB, CHLs and of MeO-PBDEs varied according to the species, maturity stage, gender and habitat type. The lowest levels of POPs were found in Atlantic stingrays and the highest levels were found in bull sharks. As both species are respectively near the bottom and at top of the trophic web, with juvenile bull sharks frequently feeding on Atlantic stingrays, these findings further suggest a bioaccumulation and biomagnification process with trophic position. MeO-PBDEs were not detected in Atlantic stingrays, but were found in all shark species. HCB was not found in Atlantic stingrays, bonnetheads or lemon sharks, but was detected in the majority of bull sharks examined. Comparison with previous studies suggests that Atlantic stingrays may be experiencing toxic effects of PCBs and DDXs on their immune system. However, the effect of these compounds on the health of shark species remains unclear. [less ▲]

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See detailPredicting biomass and grain protein content using Bayesian methods
Mansouri, Majdi ULg; Destain, Marie-France ULg

in Stochastic Environmental Research & Risk Assessment (2015)

This paper deals with the problem of predicting biomass and grain protein content using improved particle filtering (IPF) based on minimizing the Kullback–Leibler divergence. The performances of IPF are ... [more ▼]

This paper deals with the problem of predicting biomass and grain protein content using improved particle filtering (IPF) based on minimizing the Kullback–Leibler divergence. The performances of IPF are compared with those of the conventional particle filtering (PF) in two comparative studies. In the first one, we apply IPF and PF at a simple dynamic crop model with the aim to predict a single state variable, namely the winter wheat biomass, and to estimate several model parameters. In the second study, the proposed IPF and the PF are applied to a complex crop model (AZODYN) to predict a winter-wheat quality criterion, namely the grain protein content. The results of both comparative studies reveal that the IPF method provides a better estimation accuracy than the PF method. The benefit of the IPF method lies in its ability to provide accuracy related advantages over the PF method since, unlike the PF which depends on the choice of the sampling distribution used to estimate the posterior distribution, the IPF yields an optimum choice of this sampling distribution, which also utilizes the observed data. The performance of the proposed method is evaluated in terms of estimation accuracy, root mean square error, mean absolute error and execution times. [less ▲]

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See detailLinear and nonlinear optical properties of functionalized CdSe quantum dots prepared by plasma sputtering and wet chemistry
Humbert, Christophe; Dahi, Abdellatif; Dalstein, Laetitia et al

in Journal of Colloid & Interface Science (2015), 445

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See detailResponse of plant functional traits during the restoration of calcareous grasslands from forest stands
Piqueray, Julien; Ferroni, Lucia; Delescaille, Louis-Marie et al

in Ecological Indicators (2015)

In this survey, we studied the response of plant functional traits to calcareous grassland restoration in the Calestienne region, Southern Belgium (restoration protocol: forest clear-cutting followed by ... [more ▼]

In this survey, we studied the response of plant functional traits to calcareous grassland restoration in the Calestienne region, Southern Belgium (restoration protocol: forest clear-cutting followed by grazing at all sites). We considered traits related to dispersal, establishment, and persistence that integrate the main challenges of plants to re-establish and survive in restored areas. Functional traits were compiled from databases and compared among (i) pre-restoration and young restoration forests; (ii) restoration areas of different ages; and (iii) old restorations and reference grasslands. The following questions were addressed: (i) What is the early response (2-4 years) in terms of plant functional trait following one restorative clear-cut event? (ii) What plants functional trait responses occur from restorative management (i.e. sheep and goat grazing)? (iii) Which differences still persist between the oldest restored parcels (10-15 years), and the historical reference grasslands? Forest clear-cuts induced several changes among functional traits, including decreased mean seed mass and certain vegetative traits (i.e. decreased phanerophytes, branching species; and increased short lifespan species i.e. annuals and biennials). During restorative management, clonal, epizoochorous and autumn germinating species were favored. Despite numerous other changes during this phase, many differences remained compared to reference grasslands. In particular, geophytes, mycorrhizal and evergreen species abundance were not approaching reference grassland values. The observed pattern helped to draw inferences on the possible mechanisms operating under vegetation recovery following restorative forest clear-cut and subsequent management were identified and described in this study. Results indicated grazing was an important factor, which increased epizoochorous species, and autumn germinating taxa that filled niches in vegetation opened by summer grazing animals. Finally, differences between old restoration and reference grasslands emphasized that management should focus on reduction in soil fertility, and geophyte rhizomatous grasses. Long-term monitoring is vital to assess if management plans are effective in the complete restoration of species functional trait assemblages. [less ▲]

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See detailQu'est-ce qu'un thème?
Badir, Sémir ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2015), 5 (2014)

We approach the notion of theme as a problematic one. Particularly, one can observe that the functions of a theme, as they are assigned by the specialists, especially in linguistics and literary studies ... [more ▼]

We approach the notion of theme as a problematic one. Particularly, one can observe that the functions of a theme, as they are assigned by the specialists, especially in linguistics and literary studies, are multiple and mutually incompatible. It is from this variety reluctant to the disciplinarized modes of knowledge that we have in mind to establish the semiological nature of the theme. Its development is a knowledge that does not bend nor to analysis neither to synthesis. In this research, the lectures made by Roland Barthes at the Collège de France serve as a guide and as an example. [less ▲]

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See detailTime’s Up! Involvement of Metamemory Knowledge, Executive Functions, and Time Monitoring in Children’s Prospective Memory Performance
Geurten, Marie ULg; Lejeune, Caroline ULg; Meulemans, Thierry ULg

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2015)

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring ... [more ▼]

This study examined time-based prospective memory (PM) in children and explored the possible involvement of metamemory knowledge and executive functions in the use of an appropriate time monitoring strategy depending on the ongoing task’s difficulty. Specifically, a sample of 72 typically developing children aged 4, 6, and 9 years old were given an original PM paradigm composed of both an ongoing procedural activity and a PM task. Half of the participants (expert group) were trained in the ongoing activity before the prospective test. As expected, results show that time monitoring had a positive effect on children’s PM performance. Furthermore, mediation analyses reveal that strategic time monitoring was predicted by metamemory knowledge in the expert group but only by executive functions in the novice group. Overall, these findings provide interesting avenues to explain how metamemory knowledge, strategy use, and executive functions interact to improve PM performance during childhood. [less ▲]

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See detailDoes reward unpredictability reflect risk?
Anselme, Patrick ULg

in Behavioural Brain Research (2015), 280(1), 119-127

Most decisions made in real-life situations are risky because they are associated with possible negative consequences. Current models of decision-making postulate that the occasional, unpredictable ... [more ▼]

Most decisions made in real-life situations are risky because they are associated with possible negative consequences. Current models of decision-making postulate that the occasional, unpredictable absence of reward that may result from free choice is a negative consequence interpreted as risk by organisms in laboratory situations. I argue that such a view is difficult to justify because, in most experimental paradigms, reward omission does not represent a cost for the decision maker. Risk only exists when unpredictability may cause a potential loss of own limited resources, whether energetic, social, financial, and so on. Thus the experimental methodologies used to test humans and non-humans relative to risk-taking seem to be limited to studying the effects of reward uncertainty in the absence of true decision cost. This may have important implications for the conclusions that can be drawn with respect to the neurobehavioural determinants of risk-taking in real-life situations. [less ▲]

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See detailAtmospheric Pressure Plasma as an Activation Step for Improving Protein Adsorption on Hydroxyapatite Powder
Ozhukil Kollath, Vinayaraj ULg; Put, Sofie; Mullens, Steven et al

in Plasma Processes and Polymers (2015)

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See detailActive faulting at the western tip of the Gulf of Corinth, Greece, from high-resolution seismic data
Beckers, Arnaud ULg; Hubert, Aurelia ULg; Beck, Christian et al

in Marine Geology (2015)

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to ... [more ▼]

The Gulf of Corinth is one of the fastest-spreading intra-continental rifts on Earth. GPS data indicate that the rift is currently opening in a NNE-SSW direction, with a rate of extension reaching up to 16 mm yr-1 in its westernmost part. Although the rest of the offshore rift has been well studied, the western tip of the rift is still poorly explored. We present an accurate map of submarine faults in this area based on two high-resolution seismic reflection surveys (single channel sparker). In the eastern part of the studied area, the sedimentary infill is affected by the known North Eratini, South Eratini and West Channel faults. Further to the west, the seafloor is mostly flat, and is bounded to the north by the normal, south-dipping, Trizonia fault. To the north, the shallower part of the Gulf shows to the east a diffuse pattern of normal and strike-slip deformation which is replaced to the west by a 7.5 km long SE striking strike-slip fault zone, called the Managouli fault zone. To the westernmost tip of the Gulf, in the Nafpaktos Basin, two fault sets with different strikes are encountered; the one with aNE-SW strike exhibits a clear strike-slip component. The western tip of the Gulf of Corinth is the only part of the Corinth Rift where convincing evidence for strike-slip movement has been found. This fault pattern is likely related to the complex deformation occurring at the diffuse junction at the western tip of the Rift between three crustal blocks: Continental Greece, Peloponnese, and the Ionian Island-Akarnia block. [less ▲]

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See detailMaternal transfer of organohalogenated compounds in sharks and stingrays
Weijs, Liesbeth; Briels, Nathalie; Adams, Douglas et al

in Marine Pollution Bulletin (2015)

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study ... [more ▼]

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study provides preliminary data on the POP transfer from pregnant females to offspring of three species (Atlantic stingrays, bonnethead, blacktip sharks) with different reproduction modes (aplacental, placental viviparity). Polychlorinated biphenyl (PCB) levels were generally higher than any other POPs. Stingrays and blacktip shark embryos contained the lowest POP concentrations while bonnetheads and the blacktip adult female had the highest concentrations. Results suggest that are more readily transferred from the mother to the embryo compared to what is transferred to ova in stingrays. Statistically significant differences in levels of selected POPs were found between embryos from the left and right uterus within the same litter as well as between female and male embryos within the same litter for bonnetheads, but not for the blacktip sharks. [less ▲]

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See detailLectures de La Reine Albemarle ou le dernier touriste. Ontologie, autobiographie, politique
Cormann, Grégory ULg

in Bulletin d'Analyse Phénoménologique (2015), 11(1),

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See detailFunctional adaptations of the bacterial chaperone trigger factor to extreme environmental temperatures
Godin-Roulling, Amandine ULg; Schmidpeter, P.A.M.; Schmid, F.X. et al

in Environmental Microbiology (2015)

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See detailEstimation of degree-days for different climatic zones of North-East India
Borah, Pallavi; Singh, Manoj Kumar; Mahapatra, Sadhan

in Sustainable Cities and Society (2015), 14

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See detailComparative biogeochemistry-ecosystem-human interactions on dynamic continental margins
Levin, Lisa A.; Liu, Kon-Kee; Kay-Christian, Emeis et al

in Journal of Marine Systems (2015), 141

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions ... [more ▼]

The ocean’s continental margins face strong and rapid change, forced by a combination of direct human activity, anthropogenic CO2-induced climate change, and natural variability. Stimulated by discussions in Goa, India at the IMBER IMBIZO III, we (1) provide an overview of the drivers of biogeochemical variation and change on margins, (2) compare temporal trends in hydrographic and biogeochemical data across different margins (3) review ecosystem responses to these changes, (4) highlight the importance of margin time series for detecting and attributing change and (5) examine societal responses to changing margin biogeochemistry and ecosystems. We synthesize information over a wide range of margin settings in order to identify the commonalities and distinctions among continental margin ecosystems. Key drivers of biogeochemical variation include long-term climate cycles, CO2-induced warming, acidification, and deoxygenation, as well as sea level rise, eutrophication, hydrologic and water cycle alteration, changing land use, fishing, and species invasion. Ecosystem responses are complex and impact major margin services including primary production, fisheries production, nutrient cycling, shoreline protection, chemical buffering, and biodiversity. Despite regional differences, the societal consequences of these changes are unarguably large and mandate coherent actions to reduce, mitigate and adapt to multiple stressors on continental margins. [less ▲]

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See detailNon-myeloablative allogeneic hematopoietic cell transplantation following fludarabine plus 2 Gy TBI or ATG plus 8 Gy TLI: a phase II randomized study from the Belgian Hematological Society
Baron, Frédéric ULg; Zachée, Pierre; Maertens, Johan et al

in Journal of Hematology & Oncology (2015), 8(4), 10118613045-014-0098-9

Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the ... [more ▼]

Background: Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Methods: Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or from 10/10 HLA-matched unrelated donors (n = 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n = 49) or 8 Gy TLI + anti-thymocyte globulin (TLI-ATG arm; n = 45) conditioning. Results: The 180-day cumulative incidences of grade II-IV acute GVHD (primary endpoint) were 12.2% versus 8.9% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Two-year cumulative incidences of moderate/severe chronic GVHD were 40.8% versus 17.8% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Five Flu-TBI patients and 10 TLI-ATG patients received pre-emptive DLI for low donor chimerism levels, while 1 Flu-TBI patient and 5 TLI-ATG patients (including 2 patients given prior pre-emptive DLIs) received a second HCT for poor graft function, graft rejection, or disease progression. Four-year cumulative incidences of relapse/progression were 22% and 50% in Flu-TBI and TLI-ATG patients, respectively (P = 0.017). Four-year cumulative incidences of nonrelapse mortality were 24% and 13% in Flu-TBI and TLI-ATG patients, respectively (P = 0.5). Finally, 4-year overall (OS) and progression-free survivals (PFS) were 53% and 54%, respectively, in the Flu-TBI arm, versus 54% (P = 0.9) and 37% (P = 0.12), respectively, in the TLI-ATG arm. Conclusions: In comparison to patients included in the Flu-TBI arm, patients included in the TLI-ATG arm had lower incidence of chronic GVHD, higher incidence of relapse and similar OS. [less ▲]

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See detailOptimal control of a Cope rearrangement by coupling the reaction path to a dissipative bath or a second active mode
Chenel, Aurélie; Meier, Christoph; Dive, Georges et al

in The Journal of Chimical Physics (2015), 142

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See detail¿Quién mató a Rosario Tijeras? Narco y culpa.
Vanden Berghe, Kristine ULg

in Bulletin of Spanish Studies (2015), 92(2), 2-19

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for ... [more ▼]

The novel Rosario Tijeras (Jorge Franco Ramos, 1999) is interpreted here from the perspective of the literary genre of the whodunnit. More particularly, the analysis investigates who is responsible for the murder of the female assassin. Taking into account the serious psychological instability of the narrator and the violations of the maxims of communicative cooperation, it is argued that he is an unreliable narrator. Such a reading of the novel as a detective story told by an unreliable narrator reveals a number of clues as to who murdered Rosario Tijeras. It also paves the way towards a new interpretation of the novel: this article argues that there is a parallelism between Franco Ramos’ novel and La virgen de los Sicarios (1994) by Fernando Vallejo: in both novels the issues of violence and guilt in societies dominated by drug trafficking are treated in a similar way. [less ▲]

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See detailNew data on the recent history of the littoral forests of southern Cameroon: an insight into the role of historical human disturbances on the current forest composition
Biwolé, Achille ULg; Morin-Rivat, Julie ULg; Fayolle, Adeline ULg et al

in Plant Ecology and Evolution (2015), 148(1), 19-28

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they ... [more ▼]

Background and aims – Prior to European colonisation of Central Africa, human populations were dispersed through the forests, where they practiced slash-and-burn cultivation. From the 19th century they were progressively concentrated in villages along roads, leaving large areas of forest derelict. In south-western Cameroon, and elsewhere in Central Africa, forest canopy is dominated by long-lived lightdemanding tree species, suggesting a possible role of human disturbance. The aim of this study was to bring new insights into the possible effect of historical human disturbances in terms of timing and spatial extent on the current forest composition. Location – Wet evergreen littoral forest in south-western Cameroon. Methods and key results – A combined vegetation sampling and archaeobotanical survey were conducted. Potsherds, oil-palm endocarps, and charcoal were found throughout the study area, suggesting generalised human occupation and anthropogenic fire. Human occupancy occurred in two periods: between 2200 and 1500 BP, and, more recently, beginning three centuries ago. High frequency of fire and the presence of Elaeis guineensis both dated recently (between 260 and 145 BP) suggest slash-and-burn shifting cultivation practices. These human-induced disturbances may coincide with the age of the current emergent lightdemanding species, the age of which can be estimated around 200 years, or with the phases of drying climate recorded in the Central African forest in the early 18th century. Conclusions – These results support the idea that historical human disturbances are one of the major factors that shaped the current forest composition in Central Africa. [less ▲]

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See detailInternational assessment of future low flow regimes and their impact on three water related sectors in the Meuse basin – a collaborative approach
Bauwens, Alexandra; Degré, Aurore ULg; Deraedt, Deborah ULg et al

in International Journal of River Basin Management (2015), 13(1), 123-135

There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to ... [more ▼]

There is a wide recognition of the watershed scale as the right scale for global water management, notably in the context of the WFD. Hence, it often refers to international management and therefore to various pre-existing regional management tools, models or even objectives. In this study we aim at describing the collaborative assessment of climate change’s effect on low flow regime and the consequences on three water related sectors: drinking water production, agriculture and electricity production. The paper highlights the choices that were made during the study that involved scientific teams, managers and stakeholders from the four main countries of the Meuse Basin. It shows that the methodological choices were operational and aimed at preserving existing methods and knowledge within each country. They led to hydrological scenarios comparable to the main available ensemble approaches and to methodologies well accepted within the concerned countries. The results of the project highlight and quantify the water scarcity that the three sectors will have to face by the end of the century mainly regarding the electricity production. They also show that common allocation rules are necessary to manage water demand during future low flow periods. [less ▲]

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See detailÉvaluation technico-économique de la production de plants de teck (Tectona grandis L.f.) dans les pépinières villageoises au Sud-Bénin
Séhouéto, Caroline K. P.; Aoudji, Augustin K. N.; Avocèvou-Ayisso, Carolle et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2015), 19(1), 32-41

The present study deals with the production of the seedlings of teak (Tectona grandis L.f.), a species used in forest plantations in southern Benin. The aim of the study was to evaluate the techniques and ... [more ▼]

The present study deals with the production of the seedlings of teak (Tectona grandis L.f.), a species used in forest plantations in southern Benin. The aim of the study was to evaluate the techniques and the profitability of teak seedling production in the community nurseries of southern Benin. [less ▲]

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See detailEffect of enzymatic treatment on rheological properties, glass temperature transition and microstructure of date syrup
Abbès, Fatma; Masmoudi, Manel; Kchaou, Wissal et al

in LWT - Food Science and Technology (2015), 60

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes ... [more ▼]

A knowledge of rheological properties is of importance in processing, handling, process design, product development and quality control. This study investigates the effect of commercial hydrolytic enzymes (pectinase and cellulase) on rheological properties and glass temperature transition of date syrup. Date syrups obtained by enzymatic extraction exhibited a quasi Newtonian behaviour. The enzyme-treated date syrups showed the highest values of activation energy (Ea). Therefore, these syrups showed the most temperature dependency. Dynamic shear results revealed viscous behaviour for date syrups indicating that both syrups displayed liquid-like behaviour. Temperature significantly affected both (G') and (G''). The glass transition temperature (Tg) of date syrups varied between -39.56 and -45.74 °C depending on their composition. Glass transition temperature of date syrups decreased linearly with an increase in water content. [less ▲]

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See detailDeformations of an elastic pipe submitted to gravity and internal fluid flow
Darbois-Texier, Baptiste ULg; Dorbolo, Stéphane ULg

in Journal Fluids and Structures (2015)

This article describes the deformation of an elastic pipe submitted to gravity and to an internal fluid flow. The pipe is clamped horizontally at one end and free at the other end. As the fluid velocity ... [more ▼]

This article describes the deformation of an elastic pipe submitted to gravity and to an internal fluid flow. The pipe is clamped horizontally at one end and free at the other end. As the fluid velocity increases, the shape changes from an elastic beam deflected by its own weight towards an horizontal posi- tion. The shape of the pipe is characterized experimentally and is compared with a theoretical model based on the Euler-Bernoulli approximation and the conservation of the fluid momentum. We study how the determination of the pipe deformation provides an estimation of the conveyed fluid flow. Finally, the vertical force produced by the conveyed fluid to lift off a mass is deduced. [less ▲]

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See detailUsing zero-inlated models to predict the relative distribution and abundance of roe deer over very large spatial scales
Bouyer, Yaëlle ULg; Rigot, Thibaud; Panzacchi, Manuela et al

in Annales Zoologici Fennici (2015), 52

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution ... [more ▼]

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution and abundance. However, the massive spatial scales at which large carnivores use the landscape presents many practical and statistical challenges for developing functional prey distribution models. Pellet-count data from >1000 km of transects gathered across southeastern Norway from 2005 to 2011 were used to derive a map of relative prey abundance for roe deer. These data were modeled using zero-inflated hurdle models using both environmental and anthropogenic variables. Snow depth and agricultural fields were the most significant variables in explaining both presence and abundance. Internal k-cross validation of the model showed medium accuracy (Spearman r = 0.35), whereas external evaluation carried out on the basis of independently collected snow-tracking data (Spearman r = 0.37) and hunting statistics (Spearman r = 0.88) showed high accuracy. The map generated can facilitate both the study of broad scale processes linking predators and prey as well as roe deer management in southeastern Norway. [less ▲]

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See detailFilter-free exhaustive odds ratio-based genome-wide interaction approach pinpoints evidence for interaction in the HLA region in psoriasis.
Grange, Laura; Bureau, Jean-Francois; Nikolayeva, Iryna et al

in BMC genetics (2015), 16(1), 11

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the ... [more ▼]

BackgroundDeciphering the genetic architecture of complex traits is still a major challenge for human genetics. In most cases, genome-wide association studies have only partially explained the heritability of traits and diseases. Epistasis, one potentially important cause of this missing heritability, is difficult to explore at the genome-wide level. Here, we develop and assess a tool based on interactive odds ratios (IOR), Fast Odds Ratio-based sCan for Epistasis (FORCE), as a novel approach for exhaustive genome-wide epistasis search. IOR is the ratio between the multiplicative term of the odds ratio (OR) of having each variant over the OR of having both of them. By definition, an IOR that significantly deviates from 1 suggests the occurrence of an interaction (epistasis). As the IOR is fast to calculate, we used the IOR to rank and select pairs of interacting polymorphisms for P value estimation, which is more time consuming.ResultsFORCE displayed power and accuracy similar to existing parametric and non-parametric methods, and is fast enough to complete a filter-free genome-wide epistasis search in a few days on a standard computer. Analysis of psoriasis data uncovered novel epistatic interactions in the HLA region, corroborating the known major and complex role of the HLA region in psoriasis susceptibility.ConclusionsOur systematic study revealed the ability of FORCE to uncover novel interactions, highlighted the importance of exhaustiveness, as well as its specificity for certain types of interactions that were not detected by existing approaches. We therefore believe that FORCE is a valuable new tool for decoding the genetic basis of complex diseases. [less ▲]

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See detailExpulsion of a uterine myoma in a patient treated with ulipristal acetate
CHANTRAINE, Frédéric ULg; POISMANS, Gaëlle ULg; Nwachuku, Julia et al

in Clinical Case Reports (2015)

Description of a spontaneous expulsion of a submucosal myoma in a patient treated with ulipristal acetate.

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See detailOak barks as raw materials for the extraction of polyphenols for the chemical and pharmaceutical sectors: a regional case study
Dedrie, Maxime; Jacquet, Nicolas ULg; Bombeck, Pierre-Louis ULg et al

in Industrial Crops and Products (2015), 70

Despite their potential for chemical recycling, residues from forest harvesting and wood processing are mostly used for industrial applications with low added value (energy, paper pulp, panels). Bark of ... [more ▼]

Despite their potential for chemical recycling, residues from forest harvesting and wood processing are mostly used for industrial applications with low added value (energy, paper pulp, panels). Bark of both oak species, Quercus robur L. 1753, Quercus petraea (Matt.) Liebl. 1784 is a by-product from sawmill and pulp mill activities. Bark is mainly used as a fuel for the same wood plants. The aim of this study is to look at the feasibility of enhancing the value of this material through the extraction of bioactive molecules such as polyphenols (i.e. catechin, gallic and ellagic acids). First, the effect of industrial storage of logs and bark on their polyphenol content was explored. Then, referring to the selection of tan oaks in the past, the question of an optimum harvesting age is addressed in order to maximize the polyphenol content of the barks. In the end, molecular diversity of bark is examined through the identification of molecules of interest, using different chromatographic analyses. The results show an effect of the industrial context and an effect of the raw material age on the chemical properties of the bark. First investigations also highlight molecules of interest and the molecular diversity, which needs to be further explored. [less ▲]

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See detailA note on the equivalence between observed and expected information functions with polytomous IRT models
Magis, David ULg

in Journal of Educational & Behavioral Statistics (2015), 40

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected ... [more ▼]

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected information functions are equivalent for the class of divide-by-total models (including partial credit, generalized partial credit, rating scale and nominal response models), but not for the class of difference models (including the graded response and modified graded response models). Yet, observed information function remains positive in both classes. Straightforward connections with dichotomous IRT models and further implications are outlined. [less ▲]

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See detailCost-effectiveness of vitamin D and calcium supplementation in the treatment of elderly women and men with osteoporosis.
Hiligsmann, Mickaël ULg; Ben Sedrine, Wafa; Bruyère, Olivier ULg et al

in European journal of public health (2015), 25(1), 20-25

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost ... [more ▼]

BACKGROUND: The supplementation with vitamin D and calcium has been recommended for elderly, specifically those with increased risk of fractures older than 65 years. This study aims to assess the cost-effectiveness of vitamin D and calcium supplementation in elderly women and men with osteoporosis and therefore to assess if this recommendation is justified in terms of cost-effectiveness. METHODS: A validated model for economic evaluations in osteoporosis was used to estimate the cost per quality-adjusted life-year (QALY) gained of vitamin D/calcium supplementation compared with no treatment. The model was populated with cost and epidemiological data from a Belgian health-care perspective. Analyses were conducted in women and men with a diagnosis of osteoporosis (i.e. bone mineral density T-score </=-2.5). A literature search was conducted to describe the efficacy of vitamin D and calcium in terms of fracture risk reduction. RESULTS: The cost per QALY gained of vitamin D/calcium supplementation was estimated at euro40 578 and euro23 477 in women and men aged 60 years, respectively. These values decreased to euro7912 and euro10 250 at the age of 70 years and vitamin D and calcium supplementation was cost-saving at the age of 80 years, meaning that treatment cost was less than the costs of treating osteoporotic fractures of the no-treatment group. CONCLUSION: This study suggests that vitamin D and calcium supplementation is cost-effective for women and men with osteoporosis aged over 60 years. From an economic perspective, vitamin D and calcium should therefore be administrated in these populations including those also taking other osteoporotic treatments. [less ▲]

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See detailCompte-rendu de l'ouvrage de M. Le Blanc et P. Trudeau: La réadaptation de l'adolescent antisocial
Mathys, Cécile ULg

in Canadian Journal of Criminology & Criminal Justice = Revue Canadienne de Criminologie et de Justice Pénale (2015), 57(1),

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See detailCharacterization of collagen fibrils after equine suspensory ligament injury: an ultrastructural and biochemical approach
Shikh Al Sook, Mohamad Khir ULg; Gabriel, Annick ULg; Salouci, Moustafa et al

in The Veterinary Journal (2015)

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril ... [more ▼]

Suspensory ligament (SL) injuries are an important cause of lameness in horses. The mechanical properties of connective tissue in normal and pathological ligaments are mainly related to the fibril morphology, as well as the collagen content and types. The purpose of this study was to evaluate, using biochemical and ultrastructural approaches, the alterations in collagen fibrils after injury. Eight Warmblood horses with visible signs of injury in only one forelimb SL were selected and specimens were examined by transmission electron microscope (TEM). Collagen types I, III and V were purified by differential salt precipitation after collagen extraction with acetic acid containing pepsin. TEM revealed abnormal organization as well as alterations in the diameter and shape of fibrils after SL injury. The bands corresponding to types I, III and V collagen were assessed by densitometry after sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE). Densitometric analysis indicated that the proportions of type III and type V collagen were significantly higher (P <0.001) in damaged tissues compared to normal tissues with a mean increase of 20.9 and 17.3% respectively. Concurrently, a significant decrease (P <0.001) in type I collagen within damaged tissues was recorded with a mean decrease of 15.2%. These alterations could be the hallmark of a decrease in the tissue quality and mechanical properties of the ligament. This provides new insight for subsequent research on tissue regeneration that may lead to the development of future treatment strategies for SL injury. [less ▲]

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See detailLes difficultés d'apprentissage procédural chez les enfants dysphasiques
Desmottes, Lise ULg; Meulemans, Thierry ULg; Maillart, Christelle ULg

in ANAE : Approche Neuropsychologique des Apprentissages chez l'Enfant (2015)

Through a review of the literature, this paper shows that linguistic and non-linguistic disorders in children with specific language impairment might be linked to difficulties in procedural learning ... [more ▼]

Through a review of the literature, this paper shows that linguistic and non-linguistic disorders in children with specific language impairment might be linked to difficulties in procedural learning, especially regarding sequential abilities. Indeed, children with specific language impairment encounter difficulties to learn visuo-motor and linguistic sequences. These difficulties are not limited to initial learning but extend to the consolidation stage in long-term memory. Finally, recent studies show that it is possible to improve procedural learning abilities, suggesting new avenues for rehabilitation. [less ▲]

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See detailEarly seed plants from Western Gondwana: Paleobiogeographical and ecological implications based on Tournaisian (Lower Carboniferous) records from Argentina
Prestianni, C.; Rustan, J.J.; Balseiro, D. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (2015), 417

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See detailDevelopment of the Lémann Index to assess digestive tract damage in patients with Crohn's disease
Pariente, B; Mary, JY; Danese, S et al

in Gastroenterology (2015), 148

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See detailTiO2 Macroscopic Fibers with Enhanced Photocatalytic Properties Obtained through a Scale-Up Semi-Industrial Process
Kinadjian, Natacha; Le Bechec, Mickael; Henrist, Catherine ULg et al

in Advanced Engineering Materials (2015), 17(1), 36-44

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See detailMultiple timescale spectral analysis
Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2015), 39(0), 69--86

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the ... [more ▼]

Abstract Spectral analysis is a classical tool for the structural analysis of structures subjected to random excitations. The most common application of spectral analysis is the determination of the steady-state second order cumulant of a linear oscillator, under the action of a stationary loading prescribed by means of its power spectral density. There exists however a broad variety of such similar problems, extending the concept to multi degree-of-freedom systems, non Gaussian excitation, slightly nonlinear oscillators or even transient excitations. In this wide class of problems, the cumulants of the response are obtained as the result of the integral of corresponding spectra over the frequency space, which is possibly multidimensional. Application of standard numerical integration techniques may be prohibitive, a reason why the spectral approach is often left aside. Besides, many engineering problems involve a clear timescale separation, usually of those pertaining to the loading and to the mechanical behavior of the system. In these problems, a proper consideration of the timescale separation results in dropping the order of integration by one, at least. This offers the possibility to derive analytical solutions, whenever the order of integration drops to zero, or to make numerical integration competitive. The paper presents this general method, together with some applications in wind and marine engineering. [less ▲]

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See detailDetermination of arsenic (III) at a nano gold modified solid carbon paste electrode
Sakira, Abdoul Karim; Somé, Issa Touridomon; Ziemons, Eric ULg et al

in Electroanalysis (2015), 27

A selective and sensitive electroanalytical method was developed for arsenic determination based on a nanogold (AuNP) modified solid carbon paste work- ing electrode (SCPE) modified in two steps (i ... [more ▼]

A selective and sensitive electroanalytical method was developed for arsenic determination based on a nanogold (AuNP) modified solid carbon paste work- ing electrode (SCPE) modified in two steps (i) physisorp- tion and (ii) additional electrodeposition of nanogold par- ticles in the presence of iodide. Copper(II) interference was solved by covering the gold layer by a self assembled mono layer (SAM) of glutathione. Using DPASV a linear response of the signal was obtained as a function of As(III) in the concentration range 0.05–20mM (4– 1498 ppb) with a limit of detection of 0.01 mM (0.9 ppb). Sample stirring and degassing were not needed. Applica- tion to the determination of arsenic(III) and (V) in un- derground water samples from Burkina Faso was success- fully achieved. [less ▲]

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See detailElevated heart rate at 24-36h after admission and in-hospital mortality in acute in non-arrhythmic heart failure.
Lancellotti, Patrizio ULg; ANCION, Arnaud ULg; Magne, Julien et al

in International journal of cardiology (2015), 182C

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study ... [more ▼]

BACKGROUND: Elevated resting heart rate is associated with worse outcomes in chronic heart failure (HF) but little is known about its prognostic impact in acute setting. The main aim of the present study was to examine the relationship between resting heart rate obtained 24-36h after admission for acute non-arrhythmic HF and in-hospital mortality. METHODS AND RESULTS: We examined the association of heart rate with in-hospital mortality in a cohort of 712 patients admitted for acute HF. None of the patients had significant arrhythmias, required invasive ventilation, or presented with acute coronary syndrome or primary valvular disease. Forty patients (5.6%) died during the hospital stay. Those patients were significantly older (78+/-9 vs. 72+/-12years; p=0.0021), had higher heart rate (92+/-22 vs. 78+/-18bpm; p<0.0001), NT pro-BNP (p=0.0005), creatinine (p=0.023), were often diabetics (p=0.026) and had lower systolic and diastolic blood pressures (p<0.05). There was a significant graded relationship between the increase in mortality rate and tertile of heart rate (p<0.01). With multivariable analysis, age (p=0.037), heart rate (p<0.0001), diastolic blood pressure (p<0.001), prior ischemic heart disease (p=0.02) and creatinine (p=0.019) emerged as independent predictors of in-hospital mortality. After adjusting for predictors of poor prognosis, patients in the highest heart rate tertile had worst outcomes when compared with those in the lowest heart rate group (p=0.007). CONCLUSIONS: Higher heart rate 24-36h after admission for acute non-arrhythmic HF is associated with increased risk of in-hospital mortality. Early targeting of elevated heart rate might represent a complementary therapeutic challenge. [less ▲]

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See detailThe impact of oregano (Origanum heracleoticum) essential oil and carvacrol on virulence gene transcription by Escherichia coli O157:H7
Mith, Hasika; Clinquart, Antoine ULg; Zhiri, Abdesselam et al

in FEMS Microbiology Letters (2015), 362

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and ... [more ▼]

The aim of the current study was to determine, via reverse transcription quantitative polymerase chain reaction (RT-qPCR) analysis, the effect of oregano essential oil (Origanum heracleoticum) and carvacrol, its major component, on the expression of virulence-associated genes in enterohaemorrhagic Escherichia coli (EHEC) O157:H7 ATCC strain 35150. Both oregano oil and carvacrol demonstrated their efficacy firstly, by inhibiting the transcription of the ler gene involved in up regulation of the LEE2, LEE3 and LEE4 promoters and of attaching and effacing lesions and secondly by decreasing both Shiga toxin and fliC genes expression. In addition, a decrease in luxS gene transcription involved in quorum sensing was observed. These results were dose dependent and showed a specific effect of O. heracleoticum and carvacrol in downregulating the expression of virulence genes in EHEC O157:H7. These findings suggest that oregano oil and carvacrol have the potential to mitigate the adverse health effects caused by virulence gene expression in EHEC O157: [less ▲]

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See detailThe neural basis of temporal order processing in past and future thought
D'Argembeau, Arnaud ULg; Jeunehomme, Olivier ULg; Majerus, Steve ULg et al

in Journal of Cognitive Neuroscience (2015), 27

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