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See detailQuantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatography
Dispas, Amandine ULg; Desfontaine, Vincent; Andri, Bertyl ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2017), 134

In the last years, supercritical fluid chromatography has largely been acknowledged as a singular and performing technique in the field of separation sciences. Recent studies highlighted the interest of ... [more ▼]

In the last years, supercritical fluid chromatography has largely been acknowledged as a singular and performing technique in the field of separation sciences. Recent studies highlighted the interest of SFC for the quality control of pharmaceuticals, especially in the case of the determination of the active pharmaceutical ingredient (API).Nevertheless, quality control requires also the determination of impurities. The objectives of the present work were to i) demonstrate the interest of SFC as a reference technique for the determination of impurities in salbutamol sulfate API and ii) to propose an alternative to a reference HPLC method from the European Pharmacopeia (EP) involving ionpairing reagent. Firstly, a screening was carried out to select the most adequate and selective stationary phase. Secondly, in the context of robust optimization strategy, the method was developed using design space methodology. The separation of salbutamol sulfate and related impurities was achieved in 7 minutes, which is seven times faster than the LC-UV method proposed by European Pharmacopeia (total run time of 50 minutes). Finally, full validation using accuracy profile approach was successfully achieved for the determination of impurities B, D, F and G in salbutamol sulfate raw material. The validated dosing range covered 50 to 150 % of the targeted concentration (corresponding to 0.3 % concentration level), LODs close to 0.5 μg/mL were estimated. The SFC method proposed in this study could be presented as a suitable fast alternative to EP LC method for the quantitative determination of salbutamol impurities. [less ▲]

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See detailGlomerular filtration rate in healthy living potential kidney donors: a meta-analysis supporting the construction of the the Full Age Spectrum equation.
Pottel, H; Hoste, L; Yayo, E et al

in Nephron (2017), 135(2), 105-119

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See detailLa littérature belge francophone en classe de FLE
Outers, Pierre ULg; Stilmant, Nicolas

in Bulletin SUF (2017), 89

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See detailResidential heat pump as flexible load for direct control service with parametrized duration and rebound effect
Georges, Emeline ULg; Cornélusse, Bertrand ULg; Ernst, Damien ULg et al

in Applied Energy (2017), 187

This paper addresses the problem of an aggregator controlling residential heat pumps to offer a direct control flexibility service. The service consists of a power modulation, upward or downward, that is ... [more ▼]

This paper addresses the problem of an aggregator controlling residential heat pumps to offer a direct control flexibility service. The service consists of a power modulation, upward or downward, that is activated at a given time period over a fixed number of periods. The service modulation is relative to an optimized baseline that minimizes the energy costs. The load modulation is directly followed by a constrained rebound effect, consisting of a delay time with no deviations from the baseline consumption and a payback time to return to the baseline state. The potential amount of modulation and the constrained rebound effect are computed by solving mixed integer linear problems. Within these problems, the thermal behavior of the building is modeled by an equivalent thermal network made of resistances and lumped capacitances. Simulations are performed for different sets of buildings typical of the Belgian residential building stock and are presented in terms of achievable modulation amplitude, deviations from the baseline and associated costs. A cluster of one hundred ideal buildings, corresponding to retrofitted freestanding houses, is then chosen to investigate the influence of each parameter defined within the service. Results show that with a set of one hundred heat pumps, a load aggregator could expect to harvest mean modulation amplitudes of up to 138 kW for an upward modulation and up to 51 kW for a downward modulation. The obtained values strongly depend on the proposed flexibility service. For example, they can decrease down to 2.6 kW and 0.4 kW, respectively, if no rebound effect is allowed. [less ▲]

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See detailAnalysis and indications on long-term forecasting of the Oceanic Niño Index with wavelet-induced components
Deliège, Adrien ULg; Nicolay, Samuel ULg

in Pure and Applied Geophysics (2017), 174(4), 1815-1826

The present paper provides an analysis and a long-term forecasting scheme of the Oceanic Niño Index (ONI) using the continuous wavelet transform. First, it appears that oscillatory components with main ... [more ▼]

The present paper provides an analysis and a long-term forecasting scheme of the Oceanic Niño Index (ONI) using the continuous wavelet transform. First, it appears that oscillatory components with main periods of about 17, 31, 43, 61 and 140 months govern most of the variability of the signal, which is consistent with previous works. Then, this information enables us to derive a simple algorithm to model and forecast ONI. The model is based on the observation that the modes extracted from the signal are generally phased with positive or negative anomalies of ONI (El Niño and La Niña events). Such a feature is exploited to generate locally stationary curves that mimic this behavior and which can be easily extrapolated to form a basic forecast. The wavelet transform is then used again to smooth out the process and finalize the predictions. The skills of the technique described in this paper are assessed through retroactive forecasts of past El Niño and La Niña events and via classic indicators computed as functions of the lead time. The main asset of the proposed model resides in its long-lead prediction skills. Consequently, this approach should prove helpful as a complement to other models for estimating the long-term trends of ONI. [less ▲]

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See detailIs langdurig ziekteverzuim voorspelbaar en meetbaar ?
Goorts, Kaat; Duchesnes, Christiane ULg; Vandenbroeck, Sofie et al

in Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde (2017), 25(2), 59-62

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See detailLe rôle des rongeurs dans la dispersion des diaspores en milieu forestier (synthèse bibliographique)
Evrard, Quentin ULg; Haurez, Barbara ULg; Doucet, Jean-Louis ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017)

Introduction. Seed dispersal is a key interaction that influences a number of ecological processes that are important to the maintenance of diversity in forest ecosystems. Rodents, mainly considered as ... [more ▼]

Introduction. Seed dispersal is a key interaction that influences a number of ecological processes that are important to the maintenance of diversity in forest ecosystems. Rodents, mainly considered as seed predators, can carry, hide and discard seeds, often transporting them over considerable distances from the parent tree and thus leading to an enhanced germination rate. The role of rodents on forest regeneration therefore depends upon several environmental variables influencing their behavior. Literature. Many publications demonstrate that rodents are mostly seed predators for many species. Nevertheless, because it is hard to define their movement pattern, the role of rodents on regeneration could be underestimated. Through scatter-hoarding, rodents may play a crucial role, particularly in those forests where anthropogenic pressures have led to a reduction in the density of large mammals. However, very few studies have been conducted in African moist forests where defaunation can be high, and the role of rodents has been very poorly studied. Conclusions. To understand the phenomenon, we suggest to further investigate the interactions between seeds and rodents by employing methods that have been commonly used on other continents. [less ▲]

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See detailApplication of design space optimization strategy to the developmentof LC methods for simultaneous analysis of 18 antiretroviral medicinesand 4 major excipients used in various pharmaceutical formulations
Habyalimana, Védaste ULg; Mbinze Kindenge, Jérémie ULg; Yemoa, Loconon ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2017), 139

tAs one of the world’s most significant public health challenges in low- and middle-income countries,HIV/AIDS deserves to be treated with appropriate medicines, however which are not spared from coun ... [more ▼]

tAs one of the world’s most significant public health challenges in low- and middle-income countries,HIV/AIDS deserves to be treated with appropriate medicines, however which are not spared from coun-terfeiting. For that, we developed screening and specific HPLC methods that can analyze 18 antiretroviralmedicines (ARV) and 4 major excipients. Design of experiments and design space methodology wereinitially applied for 15 ARV and the 4 excipients with prediction thanks to Monte Carlo simulations andfocusing on rapidity and affordability thus using short column and low cost organic solvent (methanol)in gradient mode with 10 mM buffer solutions of ammonium hydrogen carbonate. Two other specificmethods dedicated to ARV in liquid and in solid dosage formulations were also predicted and opti-mized. We checked the ability of one method for the analysis of a fixed-dose combination composedby emtricitabine/tenofovir/efavirenz in tablet formulations. Satisfying validation results were obtainedby applying the total error approach taking into account the accuracy profile as decision tool. Then, thevalidated method was applied to test two samples coded A and B, and claimed to contain the tested ARV.Assay results were satisfying only for sample B. [less ▲]

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See detailInduced Drag Calculations with the Unsteady Vortex Lattice Method for Cambered Wings
Lambert, Thomas ULg; Dimitriadis, Grigorios ULg

in AIAA Journal (2017), 55(2), 668-672

The Unsteady Vortex Lattice Method (UVLM) is an approach widely used to estimate the aerodynamic loads in unsteady subsonic flows. It is based on modeling the camber surface of a lifting body by means of ... [more ▼]

The Unsteady Vortex Lattice Method (UVLM) is an approach widely used to estimate the aerodynamic loads in unsteady subsonic flows. It is based on modeling the camber surface of a lifting body by means of bound vortex rings. Even though this method has been known and used for several decades, there is little discussion of the modeling of the leading-edge suction in the literature. To address this concern, Simpson et al. [1] presented a comparison of two different ways to model this effect for the case of uncambered airfoils and wings in harmonic pitch or plunge motions. They concluded that the Joukowski method converges significantly faster than the Katz technique as the number of chorwise panels is increased. The present paper is an extension of the study by Simpson et al. to cambered lifting surfaces. It shows that the presence of camber can change radically the convergence performance of the two methods. For cambered wings, the Katz approach converges significantly faster than the Joukowski technique. [less ▲]

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See detailThe recent increase of atmospheric methane from 10 years of ground-based NDACC FTIR observations since 2005
Bader, Whitney ULg; Bovy, Benoît ULg; Conway, Stephanie et al

in Atmospheric Chemistry and Physics (2017)

Changes of atmospheric methane total columns (CH4/ since 2005 have been evaluated using Fourier transform infrared (FTIR) solar observations carried out at 10 ground-based sites, affiliated to the Network ... [more ▼]

Changes of atmospheric methane total columns (CH4/ since 2005 have been evaluated using Fourier transform infrared (FTIR) solar observations carried out at 10 ground-based sites, affiliated to the Network for Detection of Atmospheric Composition Change (NDACC). From this, we find an increase of atmospheric methane total columns of 0.31±0.03 %/year (2-sigma level of uncertainty) for the 2005–2014 period. Comparisons with in situ methane measurements at both local and global scales show good 10 agreement. We used the GEOS-Chem chemical transport model tagged simulation, which accounts for the contribution of each emission source and one sink in the total methane, simulated over 2005–2012. After regridding according to NDACC vertical layering using a conservative 15 regridding scheme and smoothing by convolving with respective FTIR seasonal averaging kernels, the GEOS-Chem simulation shows an increase of atmospheric methane total columns of 0.35±0.03 %/year between 2005 and 2012, which is in agreement with NDACC measurements over the same time period (0.30±0.04 %/year, averaged over 10 stations). Analysis of the GEOS-Chem-tagged simulation allows us to quantify the contribution of each tracer to the global methane change since 2005. We find that natural sources such as wetlands and biomass burning contribute to the interannual variability of methane. However, anthropogenic emissions, such as coal mining, and gas and oil transport and exploration, which are mainly emitted in the Northern Hemisphere and act as secondary contributors to the global budget of methane, have played a major role in the increase of atmospheric methane observed since 2005. Based on the GEOS-Chem-tagged simulation, we discuss possible cause(s) for the increase of methane since 2005, which is still unexplained. [less ▲]

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See detailMeasurement of pleural pressure swings with a fluid-filled esophageal catheter vs pulmonary artery occlusion pressure
VERSCHEURE, Sara ULg; MASSION, Paul ULg; GOTTFRIED, S et al

in Journal of Critical Care (2017), 37

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See detailLes marqueurs biologiques de l’arthrose: De la découverte à l’analyse biologique de routine
Henrotin, Yves ULg

in Rhumatos (2017), 14(123), 180-183

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See detailPrix fixe du livre : les propositions belges contredisent-elles le droit européen de la concurrence ?
Van Cleynenbreugel, Pieter ULg

in Tijdschrift voor Belgische Mededinging [=TBM] = Revue de la Concurrence Belge [=RCB] (2017), 4

Cet article analyse la compatibilité des propositions par les gouvernements communautaires belges des décrets relatifs aux prix fixes du livre, d'un point de vue du droit du marché intérieur ainsi que du ... [more ▼]

Cet article analyse la compatibilité des propositions par les gouvernements communautaires belges des décrets relatifs aux prix fixes du livre, d'un point de vue du droit du marché intérieur ainsi que du droit européen de la concurrence. [less ▲]

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See detailTowards a community-based concession model in the DRC
Vermeulen, Cédric ULg; Karsenty, Alain

in International Forestry Review (2017)

In 2014 Decree 14/018 laying down the rules for granting forest concessions to local communities, followed by Ministerial Order 0/25 on the same issue, was published in the DRC. This paper aims to analyse ... [more ▼]

In 2014 Decree 14/018 laying down the rules for granting forest concessions to local communities, followed by Ministerial Order 0/25 on the same issue, was published in the DRC. This paper aims to analyse the abovementioned legislation with respect to participatory management of forests. The explicit recognition of the duality of a customary de facto local community forest and a modern legal entity (concession) is an innovation. However, viewed from the perspective of the long-established habits within the country, the question remains whether these legal measures can be sufficient for ensuring the sustainable development of these community-held forested areas. Allowing community concessions up to 50,000 ha demonstrated a shift in the government policy away from the industrial timber cultivation model. However, an area this size is much larger than the communities can monitor, particularly in the case of artisanal charcoal or wood exploitation. [less ▲]

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See detailTwo-domain and three-domain limit cycles in a typical aeroelastic system with freeplay in pitch
Verstraelen, Edouard ULg; Dimitriadis, Grigorios ULg; Dal Ben Rossetto, Gustavo et al

in Journal of Fluids & Structures (2017), 69

Freeplay is a significant source of nonlinearity in aeroelastic systems and is strictly regulated by airworthiness authorities. It splits the phase plane of such systems into three piecewise linear ... [more ▼]

Freeplay is a significant source of nonlinearity in aeroelastic systems and is strictly regulated by airworthiness authorities. It splits the phase plane of such systems into three piecewise linear subdomains. Depending on the location of the freeplay, limit cycle oscillations can result that span either two or three of these subdomains. The purpose of this work is to demonstrate the existence of two-domain cycles both theoretically and experimentally. A simple aeroelastic system with pitch, plunge and control deflection degrees of freedom is investigated in the presence of freeplay in pitch. It is shown that two-domain and three-domain cycles can result from a grazing bifurcation and propagate in the decreasing airspeed direction. Close to the bifurcation, the two limit cycle branches interact with each other and aperiodic oscillations ensue. Equivalent linearization is used to derive the conditions of existence of each type of limit cycle and to predict their amplitudes and frequencies. Comparisons with measurements from wind tunnel experiments demonstrate that the theory describes these phenomena with accuracy. [less ▲]

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See detailThe constant of recognizability is computable for primitive morphisms
Durand, Fabien; Leroy, Julien ULg

in Journal of Integer Sequences (2017), 20(4),

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See detailThe Martian diffuse aurora: a model of ultraviolet and visible emissions
Gérard, Jean-Claude ULg; Soret, Lauriane ULg; Shematovich, V.I. et al

in Icarus (2017), 288

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar ... [more ▼]

A new type of Martian aurora, characterized by an extended spatial distribution, an altitude lower than the discrete aurora and electron precipitation up to 200 keV has been observed following solar activity on several occasions from the MAVEN spacecraft. We describe the results of Monte Carlo simulations of the production of several ultraviolet and violet auroral emissions for initial electron energies extending from 0.25 to 200 keV. These include the CO2+ ultraviolet doublet (UVD) at 288.3 and 289.6 nm and the Fox–Duffendack–Barker (FDB) bands, CO Cameron and Fourth Positive bands, OI 130.4 and 297.2 nm and CI 156.1 nm and 165.7 nm multiplets. We calculate the nadir and limb production rates of several of these emissions for a unit precipitated energy flux. Our results indicate that electrons in the range 50-200 keV produce maximum CO2+ UVD emission below 75 km, in agreement with the MAVEN observations. We calculate the efficiency of photon production per unit precipitated electron power. The strongest emissions are the CO2+ FDB, UVD and CO Cameron bands and the oxygen mission at 297.2 nm. The metastable a 3Π state which radiates the Cameron bands is deactivated by collisions below about 110 km. As a consequence, we show that the Cameron band emission is expected to peak at a higher altitude than the CO2+ UVD and FDB bands. Collisional quenching also causes the intensity ratio of the CO2+ UVD to CO Cameron bands to increase below ∼100 km in the energetic diffuse aurora. [less ▲]

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See detailMultiscale model of the human cardiovascular system: Description of heart failure and comparison of contractility indices
Kosta, Sarah ULg; Negroni, Jorge; Lascano, Elena et al

in Mathematical Biosciences (2017), 284

A multiscale model of the cardiovascular system is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological ... [more ▼]

A multiscale model of the cardiovascular system is presented. Hemodynamics is described by a lumped parameter model, while heart contraction is described at the cellular scale. An electrophysiological model and a mechanical model were coupled and adjusted so that the pressure and volume of both ventricles are linked to the force and length of a half-sarcomere. Particular attention was paid to the extreme values of the sarcomere length, which must keep physiological values. This model is able to reproduce healthy behavior, preload variations experiments, and ventricular failure. It also allows to compare the relevance of standard cardiac contractility indices. This study shows that the theoretical gold standard for assessing cardiac contractility, namely the end-systolic elastance, is actually load-dependent and therefore not a reliable index of cardiac contractility. [less ▲]

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See detailA specific immune and lymphatic profile characterizes the pre-metastatic state of the sentinel lymph node in patients with early cervical cancer
Balsat, Cédric ULg; Blacher, Silvia ULg; Herfs, Michael ULg et al

in Oncoimmunology (2017), 6(2), 1265718

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its ... [more ▼]

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its specific dissemination through a complex bilateral pelvic lymphatic system, early cervical cancer is a relevant candidate for investigating the early nodal metastatic process. In the present study, we analyzed in-depth both the lymphatic vasculature and the immune climate of pre-metastatic sentinel LN (SLN), in 48 cases of FIGO stage IB1 cervical neoplasms. An original digital image analysis methodology was used to objectively determine whole slide densities and spatial distributions of immunostained structures. We observed a marked increase in lymphatic vessel density (LVD) and a specific capsular and subcapsular distribution in pre-metastatic SLN when compared with non-sentinel counterparts. Such features persisted in the presence of nodal metastatic colonization. The inflammatory profile attested by CD8+, Foxp3, CD20 and PD-1expression was also significantly increased in pre-metastatic SLN. Remarkably, the densities of CD20+ B cells and PD-1 expressing germinal centers were positively correlated with LVD. All together, these data strongly support the existence of a pre-metastatic dialog between the primary tumor and the first nodal relay. Both lymphatic and immune responses contribute to the elaboration of a specific pre-metastatic microenvironment in human SLN. Moreover, this work provides evidence that, in the context of early cervical cancer, a pre-metastatic lymphangiogenesis occurs within the SLN (pre-metastatic niche) and is associated with a specific humoral immune response. [less ▲]

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See detailLearning from blind tests: Determining the function of experimental grinding stones through use-wear and residue analysis
Hayes, Elspeth H.; Cnuts, Dries ULg; Lepers, Christian et al

in Journal of Archaeological Science: Reports (2017), 11

Abstract Blind tests provide an objective means to evaluate the accuracy of functional interpretations based on the presence of use-wear and residue traces on stone tools. Previous blind tests have ... [more ▼]

Abstract Blind tests provide an objective means to evaluate the accuracy of functional interpretations based on the presence of use-wear and residue traces on stone tools. Previous blind tests have highlighted interpretive errors commonly associated with use-wear and residue analyses leading to significant methodological developments in each of the respective fields. While a number of blind tests have been performed on flaked stone tools, only a single blind test has been published for use-wear on grinding tools. We present the results of a two-part blind test performed on 15 experimental grinding implements that were used in a controlled setting, designed to evaluate the relative importance of residue analysis for determining the worked material (1) when contextual information is available and (2) when contextual information is absent. We argue that use-wear and residue analyses are successful procedures to identify the use of grinding stones, and that residue analysis may be a particularly valuable means for determining the worked material on tools that have insufficient use-wear development. We suggest that residues should be sufficiently abundant to infer use, if we are to avoid the potential confusion caused by contamination. [less ▲]

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See detailChez Froidmont au Nord : lectures polyphoniques d’une quête identitaire
Baiwir, Esther ULg; Adams, Juliette; Demonchaux, Chloé et al

in Tortue verte. Revue en ligne des littératures francophones (2017)

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See detailVoyage[s] à travers le thymus
Geenen, Vincent ULg

in Science et Culture (2017), (465), 14-15

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See detailThe importance of open data and software: Is energy research lagging behind?
Pfenninger, Stefan; DeCariolis, Joseph; Hirth, Lion et al

in Energy Policy (2017)

Energy policy often builds on insights gained from quantitative energy models and their underlying data. As climate change mitigation and economic concerns drive a sustained transformation of the energy ... [more ▼]

Energy policy often builds on insights gained from quantitative energy models and their underlying data. As climate change mitigation and economic concerns drive a sustained transformation of the energy sector, transparent and well-founded analyses are more important than ever. We assert that models and their associated data must be openly available to facilitate higher quality science, greater productivity through less duplicated effort, and a more effective science-policy boundary. There are also valid reasons why data and code are not open: ethical and security concerns, unwanted exposure, additional workload, and institutional or personal inertia. Overall, energy policy research ostensibly lags behind other fields in promoting more open and reproducible science. We take stock of the status quo and propose actionable steps forward for the energy research community to ensure that it can better engage with decision-makers and continues to deliver robust policy advice in a transparent and reproducible way. [less ▲]

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See detailEvaluation of the ruminal function of Belgian dairy cows suspected of subacute ruminal acidosis.
Lessire, Françoise ULg; Knapp, Emilie; Theron, Léonard et al

in Vlaams Diergeneeskundig tijdschrift (2017), 86(1), 16-23

Subacute ruminal acidosis (SARA) has been considered a major pathology in high producing dairy herds for years. These findings were corroborated by several studies in Europe. However, different feeding ... [more ▼]

Subacute ruminal acidosis (SARA) has been considered a major pathology in high producing dairy herds for years. These findings were corroborated by several studies in Europe. However, different feeding practices and herds’ production levels are found in Southern Belgium. This study aimed to ascertain whether dairy cows of several herds from the south of Belgium (Wallonia) with a suspicion of SARA really did present too low ruminal pH values. Twenty-four herds were visited and 172 cows were sampled using an oropharyngeal device to collect ruminal fluid, i.e. Geishauser probe. On the samples, three tests were performed: pH measurement, methylene blue reduction test and microscopic evaluation of protozoa vitality. Based on these analyses, no cows demonstrated pH values lower than 5.5 and, only ten cows could be considered at risk for SARA. By contrast, in eightteen cows, pH values higher than 7.0 were measured and ruminal inactivity was suspected. In this study, ruminal alkalosis appeared to be more frequently observed than SARA. [less ▲]

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See detailAdverse Health Events Related to Self-Medication Practices Among Elderly: A Systematic Review.
Locquet, Médéa ULg; Honvo, Germain ULg; Rabenda, Véronique ULg et al

in Drugs & Aging (2017)

BACKGROUND: Older adults often resort to self-medication to relieve symptoms of their current illnesses; however, the risks of this practice are multiplied in old age. In particular, this age group is ... [more ▼]

BACKGROUND: Older adults often resort to self-medication to relieve symptoms of their current illnesses; however, the risks of this practice are multiplied in old age. In particular, this age group is more vulnerable to adverse drug events because of the physiological changes that occur due to senescence. OBJECTIVE: The aim of the study was to obtain an overview of the adverse health events related to self-medication among subjects aged 60 years and over through a systematic review of the literature. METHODS: A study of relevant articles was conducted among databases (MEDLINE, PsycINFO, and EBM Reviews-Cochrane Database of Systematic Reviews). Eligibility criteria were established and applied by two investigators to include suitable studies. The results and outcomes of interest were detailed in a descriptive report. RESULTS: The electronic search identified 4096 references, and the full texts of 74 were reviewed, of which four were retained in the analysis: three had a cross-sectional design and one prospectively followed elderly subjects. The first study showed a 26.7% prevalence of adverse drug reactions (ADRs) among elders, the second study found a 75% prevalence of side effects, and, finally, a prospective study showed an ADR incidence of 4.5% among self-medicated elders. These studies showed that adverse health events related to self-medication are relatively frequently reported. They also highlighted that analgesics and anti-inflammatory drugs are the most self-medicated products, while vitamins and dietary supplements also appear to be frequently self-administered, but by older individuals. CONCLUSIONS: Studies on self-medication in the elderly and its adverse health effects are clearly lacking. There is a need to perform prospective studies on this topic to gain a clear understanding of the extent of this problem and to enhance the awareness of health professionals to better inform seniors. [less ▲]

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See detailLes ASBL et le Tax Shelter : un cadeau empoisonné ?
Garroy, Sabine ULg

in ASBL Actualités (2017)

Une loi du 25 décembre 2016 a étendu le régime du Tax Shelter, réservé jusqu’ici aux « œuvres audiovisuelles », aux œuvres dites « scéniques » (visant ainsi notamment l’opéra, le cirque, le théâtre ou ... [more ▼]

Une loi du 25 décembre 2016 a étendu le régime du Tax Shelter, réservé jusqu’ici aux « œuvres audiovisuelles », aux œuvres dites « scéniques » (visant ainsi notamment l’opéra, le cirque, le théâtre ou encore le ballet). Outre un rappel du système Tax Shelter (I), les spécificités du régime applicable aux « œuvres scéniques » (II) sont présentées. Si les ASBL peuvent s’inscrire dans la dynamique du Tax Shelter en tant que société de production éligible ou intermédiaire, elles seront par conséquent assujetties à l’impôt des sociétés (ci-après : ISOC), et ce, pour une certaine durée ; nous nous demandons enfin si le législateur a réservé, par le biais cette loi de Noël dernier, un si joli présent aux ASBL (III). [less ▲]

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See detailTraitement du pectus excavatum chez le chat
Hamon, Martin ULg; Claeys, Stéphanie ULg

in Monde Vétérinaire (Le) (2017), 166

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See detailDe l'évaluation des Enseignements à la régulation des pratiques des enseignants: quels possibles et quelles conditions ?
Detroz, Pascal ULg; Verpoorten, Dominique ULg

in Education & Formation (2017), e307

Cet article propose une modélisation des divers usages des résultats de l’évaluation des enseignements par les étudiants (EEE). Nous considérons l’usage et les effets sur les enseignements, mais également ... [more ▼]

Cet article propose une modélisation des divers usages des résultats de l’évaluation des enseignements par les étudiants (EEE). Nous considérons l’usage et les effets sur les enseignements, mais également ceux produits sur le développement pédagogique des enseignants. Nous déterminons ensuite certains éléments du dispositif EEE favorisant une utilisation accrue et pertinente. [less ▲]

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See detailClinical settings in knee osteoarthritis: Pathophysiology guides treatment
Herrero-Beaumont, Gabriel; Roman-Blas, Jorge A; Bruyère, Olivier ULg et al

in Maturitas (2017), 96

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with ... [more ▼]

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage. Thus, the expression of a clinical phenotype in the early stages of OA relies on the main underlying pathway and predominant joint tissue involved at a given time. Moreover, OA often coexists with other morbidities in the same patient, which in turn condition the OA process. In this scenario, an appropriate identification of clinical phenotypes, especially in the early stages of the disease, may optimize the design of individualized treatments in OA. An ESCEO-EUGMS (European Union Geriatric Medicine Society) working group has recently suggested possible patient profiles in OA. Hereby, we propose the existence of 4 clinical phenotypes – biomechanical, osteoporotic, metabolic and inflammatory – whose characterization would help to properly stratify patients with OA in clinical trials or studies. Further research in this field is warranted. [less ▲]

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See detailPédagogie universitaire et Evaluation de l’enseignement par les étudiants 
Younes, Nathalie; Paivendi, Saeed; Detroz, Pascal ULg

in Education & Formation (2017), e307

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See detailDescription of patients consulting the voice clinic regarding gender, age, occupational status, and diagnosis
Remacle, Angélique ULg; Petitfils, Cloé; FINCK, Camille ULg et al

in European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) (2017), 274(3), 1567-1576

Purpose. To describe the gender, age, occupational status and diagnosis of dysphonic patients. Method. We retrospectively analyzed the medical records of 1079 patients examined at the Voice clinic of the ... [more ▼]

Purpose. To describe the gender, age, occupational status and diagnosis of dysphonic patients. Method. We retrospectively analyzed the medical records of 1079 patients examined at the Voice clinic of the University hospital of Liège in French-speaking Belgium. Results. Overall, seven out of 10 patients who attended the voice clinic for dysphonia were females. The patients’ ages ranged from 4 to 93 (mean=43.5). Females predominantly consulted at the age of 54 and males at the age of 9. Regarding the occupational status, workers represented more than half of our patients (53%), while 11.2% were unemployed, 15.4% were students, and 19.9% were retired. Regarding the diagnoses of the 1079 patients, nodules were the most common pathologies (n=182, 16.9% of the patients), prevailing in females (n=142, 18.8% of the females), encountered in 16.8% of the workers and 42.8% of the students consulting the voice clinic. Following nodules, laryngeal mobility disorders were diagnosed in 16.4% of the patients (n=177), mainly females (n=115), and was the most frequent diagnosis in retirees (n=75, 34.9%). Conclusions. The majority of the patients consulting the voice clinic for dysphonia were adult females, in their workforce, diagnosed with vocal nodules. The identification of the patients’ characteristics and diagnoses is important to develop treatments and prevention of dysphonia, estimate their costs, and allow comparisons across referral centers. [less ▲]

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See detailPhenotypes to genetically reduce greenhouse gas emissions in dairying
de Haas, Yvette; Pszczola, Marcin; Soyeurt, Hélène ULg et al

in Journal of Dairy Science (2017), 100(2), 855-870

Phenotypes have been reviewed to select for lower-emitting animals in order to decrease the environmental footprint of dairy cattle products. This includes direct selection for breath measurements, as ... [more ▼]

Phenotypes have been reviewed to select for lower-emitting animals in order to decrease the environmental footprint of dairy cattle products. This includes direct selection for breath measurements, as well as indirect selection via indicator traits such as feed intake, milk spectral data, and rumen microbial communities. Many of these traits are expensive or difficult to record, or both, but with genomic selection, inclusion of methane emission as a breeding goal trait is feasible, even with a limited number of registrations. At present, methane emission is not included among breeding goals for dairy cattle worldwide. There is no incentive to include enteric methane in breeding goals, although global warming and the release of greenhouse gases is a much-debated political topic. However, if selection for reduced methane emission became a reality, there would be limited consensus as to which phenotype to select for: methane in liters per day or grams per day, methane in liters per kilogram of energy-corrected milk or dry matter intake, or a residual methane phenotype, where methane production is corrected for milk production and the weight of the cow. We have reviewed the advantages and disadvantages of these traits, and discuss the methods for selection and consequences for these phenotypes. [less ▲]

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See detailEnonciation et modes d'existence
Dondero, Maria Giulia ULg

in Nouveaux Actes Sémiotiques (2017), 120

Cet article aborde les relations entre sémiotique et philosophie latourienne à partir de la théorie de l’énonciation, cette dernière se situant tant aux fondements du projet disciplinaire de la sémiotique ... [more ▼]

Cet article aborde les relations entre sémiotique et philosophie latourienne à partir de la théorie de l’énonciation, cette dernière se situant tant aux fondements du projet disciplinaire de la sémiotique francophone contemporaine qu’à la base de la réflexion de Bruno Latour, des années 1970 jusqu’à présent . Notre propos se déploie en deux moments : dans un premier temps, nous revenons sur l’article "Petite Philosophie de l’énonciation" (1998), et nous en suivons le développement dans l’Enquête sur les modes d’existence (2012). Dans un second temps, nous réalisons une rapide archéologie de la théorie de l’énonciation dans la sémiotique contemporaine, afin de mettre en lumière les liens entre différentes traditions sémiotiques et la théorie latourienne. Plus précisément, nous nous attachons aux propositions récentes de Jacques Fontanille et de Claudio Paolucci, en prenant également en considération les contributions d’Umberto Eco et Patrizia Violi. Il s’agit de voir comment les sémioticiens peuvent tirer profit de la théorie latourienne des modes d’existence et vice versa. [less ▲]

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See detailReconstructing the Holocene depositional environments along the northern coast of Sfax (Tunisia): Mineralogical and sedimentological approaches
Lamourou, Ali ULg; Touir, Jamel; Fagel, Nathalie ULg

in Journal of African Earth Sciences (2017), 129C

A sedimentological and mineralogical study of sedimentary cores allows reconstructing the evolution of depositional environments along the Northern coast of Sfax (Tunisia). The aim is identifying the ... [more ▼]

A sedimentological and mineralogical study of sedimentary cores allows reconstructing the evolution of depositional environments along the Northern coast of Sfax (Tunisia). The aim is identifying the factors controlling the sedimentation from the Holocene to the Present. Three 30-m sediment cores collected by drilling at 30 meter water depth were analyzed for their color, magnetic susceptibility signal, grain size by laser diffraction, organic matter content by loss of ignition, carbonate content by calcimetry and mineralogy by X-ray diffraction on bulk powder and clay < 2 m. The three cores broadly present the same sedimentological and mineralogical features. Microscopical observations of petrographic slides allow to identifying six main sedimentary facies. Bulk mineralogical assemblages comprise clay minerals, quartz, calcite, gypsum and K-feldspars. The main change concerns the carbonate content that mimics the bioclaste abundance and dilute the detrital minerals (clay minerals, quartz and feldspars). The gypsum mainly occurs in the lower sedimentary columns (SC12 and SC9) and in the upper/middle of core SC6. The clay fraction is made of a mixture of kaolinite, illite, smectite and palygorskite with no clear variation through core depth. Both grain-size parameters and magnetic susceptibility profile indicates a sharp transition in the upper 2 to 5 m of the sedimentological columns. Coarse, sandy to gravely, sediments characterized by a low magnetic susceptibility signal are replaced by fine bioclastic-rich clayey sediments. The analysis of vertical succession of depositional facies showed a fluvial depositional environment (coastal plain) basically marked by fluvial channels and inundation plains at the bottom of all cores. Core-top sediments, however, record a littoral marine environment characterized by sand depositions rich in gastropods, lamellibranches and algæ. Depositional facies, sedimentological and mineralogical parameters are consistent with a transition from a continental, fluviatile, depositional environment, with some emersion phases marked by the gypsum precipitation to a marine littoral environment. Such evolution is consistent with a relative sea-level rise which flooded the fluvial system at the coastal plain during the Holocene, in agreement with sea-level fluctuations in southeast Tunisia during the Holocene. [less ▲]

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See detailL'énonciation d'une synthèse
Badir, Sémir ULg

in Nouveaux Actes Sémiotiques (2017)

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See detailSeasonal variations in drag coefficient over a sastrugi-covered snowfield in coastal East Antarctica
Amory, Charles ULg; Gallee, Hubert; Naaim-Bouvet, Florence et al

in Boundary-Layer Meteorology (2017)

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See detailCyanobacterial Contribution to Travertine Deposition in the Hoyoux River System, Belgium
Kleinteich, Julia; Golubic, Stjepko; Pessi, Igor S. et al

in Microbial Ecology (2017)

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate ... [more ▼]

Travertine deposition is a landscape-forming process, usually building a series of calcareous barriers differentiating the river flow into a series of cascades and ponds. The process of carbonate precipitation is a complex relationship between biogenic and abiotic causative agents, involving adapted microbial assemblages but also requiring high levels of carbonate saturation, spontaneous degassing of carbon dioxide and slightly alkaline pH. We have analysed calcareous crusts and water chemistry from four sampling sites along the Hoyoux River and its Triffoy tributary (Belgium) in winter, spring, summer and autumn 2014. Different surface textures of travertine deposits correlated with particular microenvironments and were influenced by the local water flow. In all microenvironments, we have identified the cyanobacterium Phormidium incrustatum (Nägeli) Gomont as the organism primarily responsible for carbonate precipitation and travertine fabric by combining morphological analysis with molecular sequencing (16S rRNA gene and ITS, the Internal Transcribed Spacer fragments), targeting both field populations and cultures to exclude opportunistic microorganisms responding favourably to culture conditions. Several closely related cyanobacterial strains were cultured; however, only one proved identical with the sequences obtained from the field population by direct PCR. This strain was the dominant primary producer in the calcareous deposits under study and in similar streams in Europe. The dominance of one organism that had a demonstrated association with carbonate precipitation presented a valuable opportunity to study its function in construction, preservation and fossilisation potential of ambient temperature travertine deposits. These relationships were examined using scanning electron microscopy and Raman microspectroscopy. [less ▲]

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See detailThe Evolution of PhD Education in Spain: A Chronological Review of Supra-national and National Actions
Aliaga Isla, Rocio ULg

in Higher Education Teaaching and Learning (2017), 7

PhD education in Spain has changed; the current conception of the PhD is different from its initial concept. PhD education policy in Spain has experienced changes in its objectives and structure. Since ... [more ▼]

PhD education in Spain has changed; the current conception of the PhD is different from its initial concept. PhD education policy in Spain has experienced changes in its objectives and structure. Since its membership into the European Community, institutional policies at supra-national and national level have shaped and conditioned such changes. Therefore, how have PhD education policies changed over a long time in Spain? To answer this question, a chronological review has been conducted under the light of institutional theory. Several legal documents enacted at supra-national level are reviewed to frame the changes of PhD education policy at a national level. Moreover, national legal documents are reviewed to follow the evolution of PhD education in Spain. This study shows that PhD education in Spain has experienced rapid changes, which are congruent to some extent with the supra-national policies that have emerged from the social and economic change in the European Union. [less ▲]

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See detailInteractions between groundwater and the cavity of an old slate mine used as lower reservoir of an UPSH (Underground Pumped Storage Hydroelectricity): A modelling approach
Bodeux, Sarah ULg; Pujades, Estanislao ULg; Orban, Philippe ULg et al

in Engineering Geology (2017), 217

In the actual evolving energy context, characterized by an increasing part of intermittent renewable sources, the development of energy storage technologies are required, such as pumped storage ... [more ▼]

In the actual evolving energy context, characterized by an increasing part of intermittent renewable sources, the development of energy storage technologies are required, such as pumped storage hydroelectricity (PSH). While new sites for conventional PSH plants are getting scarce, it is proposed to use abandoned underground mines as lower reservoirs for Underground Pumped Storage Hydroelectricity (UPSH). However, the hydrogeological consequences produced by the cyclic solicitations (continuous pumpings and injections) have been poorly investigated. Therefore, in this work, groundwater interactions with the cyclically fill and empty cavity were numerically studied considering a simplified description of a slate mine. Two pumping/injection scenarios were considered, both for a reference slate rock case and for a sensitivity analysis of variations of aquifer hydraulic conductivity value. Groundwater impacts were assessed in terms of oscillations of piezometric heads and mean drawdown around the cavity. The value of the hydraulic conductivity clearly influences the magnitude of the aquifer response. Studying interactions with the cavity highlighted that seepage into the cavity occurs over time. The volume of seeped water varies depending on the hydraulic conductivity and it could become non-negligible in the UPSH operations. These preliminary results allow finally considering first geological feasibility aspects, which could vary conversely according to the hydraulic conductivity value and to the considered groundwater impacts. [less ▲]

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See detailBeech wood Fagus sylvatica dilute-acid hydrolysate as a feedstock to support Chlorella sorokiniana biomass, fatty acid and pigment production
Miazek, Krystian ULg; Remacle, Claire ULg; Richel, Aurore ULg et al

in Bioresource Technology (2017), 230(April 2017), 122131

This work evaluates the possibility of using beech wood (Fagus sylvatica) dilute-acid (H2SO4) hydrolysate as a feedstock for Chlorella sorokiniana growth, fatty acid and pigment production. Neutralized ... [more ▼]

This work evaluates the possibility of using beech wood (Fagus sylvatica) dilute-acid (H2SO4) hydrolysate as a feedstock for Chlorella sorokiniana growth, fatty acid and pigment production. Neutralized wood acid hydrolysate, containing organic and mineral compounds, was tested on Chlorella growth at different concentrations and compared to growth under phototrophic conditions. Chlorella growth was improved at lower loadings and inhibited at higher loadings. Based on these results, a 12% neutralized wood acid hydrolysate (Hyd12%) loading was selected to investigate its impact on Chlorella growth, fatty acid and pigment production. Hyd12% improved microalgal biomass, fatty acid and pigment productivities both in light and in dark, when compared to photoautotrophic control. Light intensity had substantial influence on fatty acid and pigment composition in Chlorella culture during Hyd12%-based growth. Moreover, heterotrophic Chlorella cultivation with Hyd12% also showed that wood hydrolysate can constitute an attractive feedstock for microalgae cultivation in case of lack of light. [less ▲]

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See detailRecent uptake of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo-Dioulasso, Burkina Faso
Cisse, Mamoudou; Awandare, Gordon; Soulama, Alamissa et al

in Malaria Journal (2017), 16

Background: The impact of sulfadoxine–pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This ... [more ▼]

Background: The impact of sulfadoxine–pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought first to explore the relationship between IPTp-SP and the presence of mutant parasites. Second, to assess the Relationship between the mutant parasites and adverse pregnancy outcomes. Methods: From September to December 2010, dried blood spots (DBS) were collected during antenatal care visits and at delivery from 109 pregnant women with microscopically confirmed falciparum malaria infection. DBS were analysed by PCR–restriction fragment length polymorphism (PCR–RFLP) for the polymorphisms at codons 51, 59, 108 and 164 of the Pfdhfr gene and codons 437 and 540 in the Pfdhps gene. Results: Both the Pfdhfr and Pfdhps genes were successfully genotyped in 92.7% (101/109) of the samples. The prevalence of Pfdhfr mutations N51I, C59R and S108N was 71.3, 42.6 and 64.4%, respectively. Overall, 80.2% (81/101) of samples carried the Pfdhps A437G mutation. None of the samples had the Pfdhfr I164L and the Pfdhps K540E mutations. The prevalence of the triple mutation N51I + C59R + S108N was 25.7% (26/101). The use of IPTp-SP was associated with a threefold increased odds of Pfdhfr C59R mutation [crude OR 3.29; 95% CI (1.44–7.50)]. Pregnant women with recent uptake of IPTp-SP were at higher odds of both the Pfdhfr C59R mutation [adjusted OR 4.26; 95% CI (1.64–11.07)] and the Pfdhfr intermediate-to-high resistance, i.e., ≥ 2 Pfdhfr mutations [adjusted OR 3.45; 95% CI (1.18–10.07)]. There was no statistically significant association between the presence of the Pfdhfr intermediate-tohigh resistance and parasite densities or both maternal haemoglobin level and anaemia. Conclusion: The data indicate that despite the possibility that IPTp-SP contributes to the selection of resistant parasites, it did not potentiate pregnancy-associated malaria morbidity, suggesting the continuation of SP use as IPTp in Burkina Faso. [less ▲]

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See detailPhotocleavable stabilizer for the preparation of PHEMA nanogels by dispersion polymerization in supercritical carbon dioxide
Alaimo, David; Grignard, Bruno ULg; Kuppan, Chandrasekar et al

in Polymer Chemistry (2017), 8(3), 581-591

A new photo-sensitive diblock copolymer composed of a hydrophilic sequence of poly(ethylene oxide) (PEO) linked to a CO2-philic sequence of poly(1H,1H,2H,2H-heptadecafluorodecyl acrylate) (PFDA) by a ... [more ▼]

A new photo-sensitive diblock copolymer composed of a hydrophilic sequence of poly(ethylene oxide) (PEO) linked to a CO2-philic sequence of poly(1H,1H,2H,2H-heptadecafluorodecyl acrylate) (PFDA) by a light sensitive o- nitrobenzyl group was successfully synthesized by RAFT polymerization and used as stabilizer for the free radical polymerization of 2-hydroxyethyl methacrylate (HEMA) in dispersion in ?,?,?-trifluorotoluene and supercritical carbon dioxide (scCO2). Thanks to this fluorinated stabilizer, well-defined particles of PHEMA down to 350 nm of diameter were produced in scCO2. Advantageously, the photocleavable group at the block junction of the stabilizer could be cleaved by exposing the particles to UV light so that the fluorinated block could be extracted in TFT or scCO2. As supported by X-ray photoelectron spectroscopy (XPS) analysis, up to 80 % of the fluorinated block of the stabilizer can be removed, leading to efficient swelling and dispersion of the resulting PHEMA nanogels in water. [less ▲]

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See detailTropospheric water vapour isotopologue data (H216O, H218O and HD16O) as obtained from NDACC/FTIR solar absorption spectra
Barthlott, Sabine; Schneider, Matthias; Hase, Frank et al

in Earth System Science Data (2017), 9

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the ... [more ▼]

We report on the ground-based FTIR (Fourier Transform InfraRed) tropospheric water vapour isotopologue remote sensing data that have been recently made available via the database of NDACC (Network for the Detection of Atmospheric Composition Change; ftp://ftp.cpc.ncep.noaa.gov/ndacc/MUSICA/) and via doi:10.5281/zenodo.48902. Currently, data are available for 12 globally distributed stations. They have been centrally retrieved and quality filtered in the framework of the MUSICA project (MUlti-platform remote Sensing of Isotopologues for investigating the Cycle of Atmospheric water). We explain particularities of retrieving the water vapour isotopologue state (vertical distribution of H162O, H182O and HD16O) and reveal the need for a new meta-data template for archiving FTIR isotopologue data. We describe the format of different data components and give recommendations for correct data usage. Data are provided as two data types. The first type is best-suited for tropospheric water vapour distribution studies disregarding different isotopologues (comparison with radiosonde data, analyses of water vapour variability and trends, etc.). The second type is needed for analysing moisture pathways by means of {H2O,delta-D}-pair distributions. [less ▲]

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See detailComparison of Various Indices of Energy Metabolism in Recumbent and Healthy Dairy Cows
Guyot, Hugues ULg; Detilleux, Johann ULg; Lebreton, Pascal et al

in PLoS ONE (2017), 12(1), 1-11

BACKGROUND: Downer cow syndrome (DCS) is often diagnosed in dairy cattle during the early post-partum period. The etiology of this condition is not completely understood, as it can be related to the ... [more ▼]

BACKGROUND: Downer cow syndrome (DCS) is often diagnosed in dairy cattle during the early post-partum period. The etiology of this condition is not completely understood, as it can be related to the energetic or electrolyte metabolism, as well as to infectious diseases or to trauma. HYPOTHESIS/OBJECTIVES: The aim of this study is to compare energy metabolism and insulin sensitivity indices and various biochemical parameters between recumbent and healthy dairy cows. ANIMALS: A prospective study has been undertaken on 361 recumbent and 80 healthy Holstein cows. METHODS: Plasmatic glucose, insulin, non-esterified fatty acid (NEFA) and β-hydroxybutyrate (BHB) were assayed in all cows in order to calculate the insulin sensitivity indices but also minerals (Calcium, Phosphorous and Magnesium), thyroxin and creatine kinase. Body Condition Scores (BCS) was assessed. RESULTS: Significant differences in NEFA, and the glucose and insulin sensitivity indices ("Homeostasis Model Assessment" HOMA, "Revised Quantitative Insulin Sensitivity Check Index" RQUICKI, RQUICKI-BHB) were observed between healthy and recumbent cows in the early post-parturient period indicating disturbances of glucose and insulin homeostasis in the recumbent cows. In the same manner, mineral concentrations were significantly different between healthy and recumbent cows. Glucose, insulin NEFA, and HOMA, were different between early post-partum downer cows and the DCS-affected cows later in lactation. CONCLUSION AND CLINICAL IMPORTANCE: Results indicate disturbances in energy homeostasis in DCS-affected dairy cows. Further research should determine a prognostic value of the indices in cows suffering from recumbency of metabolic origin [less ▲]

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See detailDiversity and carbon storage across the tropical forest biome
Sullivan, Martin J.P.; Talbot, Joey; Lewis, Simon L. et al

in Scientific Reports (2017), 7(39102),

Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation ... [more ▼]

Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified. Here, we compile a unique pan-Tropical dataset of 360 plots located in structurally intact old-growth closed-canopy forest, surveyed using standardised methods, allowing a multi-scale evaluation of diversity-carbon relationships in tropical forests. Diversity-carbon relationships among all plots at 1 ha scale across the tropics are absent, and within continents are either weak (Asia) or absent (Amazonia, Africa). A weak positive relationship is detectable within 1 ha plots, indicating that diversity effects in tropical forests may be scale dependent. The absence of clear diversity-carbon relationships at scales relevant to conservation planning means that carbon-centred conservation strategies will inevitably miss many high diversity ecosystems. As tropical forests can have any combination of tree diversity and carbon stocks both require explicit consideration when optimising policies to manage tropical carbon and biodiversity. [less ▲]

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See detailPresent-day central African forest is a legacy of the 19th century human history
Morin, Julie ULg; Fayolle, Adeline ULg; Favier, Charly et al

in eLife (2017)

The populations of light-demanding trees that dominate the canopy of central African forests are now aging. Here, we show that the lack of regeneration of these populations began ca. 165 ya (around 1850 ... [more ▼]

The populations of light-demanding trees that dominate the canopy of central African forests are now aging. Here, we show that the lack of regeneration of these populations began ca. 165 ya (around 1850) after major anthropogenic disturbances ceased. Since 1885, less itinerancy and disturbance in the forest has occurred because the colonial administrations concentrated people and villages along the primary communication axes. Local populations formerly gardened the forest by creating scattered openings, which were sufficiently large for the establishment of light-demanding trees. Currently, common logging operations do not create suitable openings for the regeneration of these species, whereas deforestation degrades landscapes. Using an interdisciplinary approach, which included paleoecological, archaeological, historical, and dendrological data, we highlight the long-term history of human activities across central African forests and assess the contribution of these activities to present-day forest structure and composition. The conclusions of this sobering analysis present challenges to current silvicultural practices and to those of the future. [less ▲]

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See detailHigh-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery
Turchetto; Sequeira, Ana Filipa; Ramond, Laurie et al

in Microbial Cell Factories (2017), 16(6), 1-15

Animal venoms are complex molecular cocktails containing a wide range of biologically active disulphide-reticulated peptides that target, with high selectivity and efficacy, a variety of membrane ... [more ▼]

Animal venoms are complex molecular cocktails containing a wide range of biologically active disulphide-reticulated peptides that target, with high selectivity and efficacy, a variety of membrane receptors. Disulphide-reticulated peptides have evolved to display improved specificity, low immunogenicity and to show much higher resistance to degradation than linear peptides. These properties make venom peptides attractive candidates for drug development. However, recombinant expression of reticulated peptides containing disulphide bonds is challenging, especially when associated with the production of large libraries of bioactive molecules for drug screening. To date, as an alternative to artificial synthetic chemical libraries, no comprehensive recombinant libraries of natural venom peptides are accessible for high-throughput screening to identify novel therapeutics. RESULTS: In the accompanying paper an efficient system for the expression and purification of oxidized disulphide-reticulated venom peptides in Escherichia coli is described. Here we report the development of a high-throughput automated platform, that could be adapted to the production of other families, to generate the largest ever library of recombinant venom peptides. The peptides were produced in the periplasm of E. coli using redox-active DsbC as a fusion tag, thus allowing the efficient formation of correctly folded disulphide bridges. TEV protease was used to remove fusion tags and recover the animal venom peptides in the native state. Globally, within nine months, out of a total of 4992 synthetic genes encoding a representative diversity of venom peptides, a library containing 2736 recombinant disulphide-reticulated peptides was generated. The data revealed that the animal venom peptides produced in the bacterial host were natively folded and, thus, are putatively biologically active. CONCLUSIONS: Overall this study reveals that high-throughput expression of animal venom peptides in E. coli can generate large libraries of recombinant disulphide-reticulated peptides of remarkable interest for drug discovery programs. [less ▲]

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See detailCryopreservation of chicken primordial germ cells by vitrification and slow-freezing: a comparative study
Tonus, Céline ULg; Connan, Delphine ULg; Waroux, Olivier ULg et al

in Theriogenology (2017), 88

In the present study, we compare a classical slow freezing method and an aseptic vitrification technique to cryopreserve a stable Primordial Gem Cells (PGCs) line issued from the Ardennaise chicken breed ... [more ▼]

In the present study, we compare a classical slow freezing method and an aseptic vitrification technique to cryopreserve a stable Primordial Gem Cells (PGCs) line issued from the Ardennaise chicken breed. Viability immediately after warming was close to 80% and did not differ between the two cryopreservation methods. Proliferation tended to be slower for both cryopreservation methods compared to controls, but the difference was significant only for vitrification. No difference was found between the two methods after flow cytometry analysis of SSEA-1 expression and RT-PCR on several factors related to PGCs phenotype. After one week in culture, all cryopreserved cells reached controls main morphological and expanding (viability/proliferation) features. However, slow freezing generated more unwanted cells clusters than vitrification. After injection of the PGCs into recipient embryos, vitrified PGCs showed a clear, yet not significant, tendency to colonize the gonad at a higher rate than slow frozen PGCs. Slow freezing in cryovials remains simple, inexpensive and less technically demanding than vitrification. Nevertheless, the intrinsic advantages of our aseptic vitrification method and the present study suggest that this should be considered as safer than classical slow freezing for cryopreserving chicken PGCs. [less ▲]

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See detailStudy on reproductive performance of Holstein x Lai Sind crossbred heifers and cows at smallholdings in Ho Chi Minh City, Vietnam.
Nguyen-Kien, Cuong; Nguyen, Van Khanh; Hanzen, Christian ULg

in Tropical Animal Health and Production (2017), 49

The reproductive performance of Holstein x Lai Sind crossbred dairy heifers and cows was evaluated at small-holdings in Ho Chi Minh City (HCMC). The data of 232 heifers and 244 cows (261 lactations) from ... [more ▼]

The reproductive performance of Holstein x Lai Sind crossbred dairy heifers and cows was evaluated at small-holdings in Ho Chi Minh City (HCMC). The data of 232 heifers and 244 cows (261 lactations) from 35 small dairy farms was collected over a 2-year period, from 2013 to 2014. The overall mean for age at first service (AFS), days between first and last service (DFLS), and age at conception (AC) of heifers was 479 (±80), 38 (±80), and 517 (±114) days, respectively. Average number of services per conception (NSC), conception rate (CR), and conception rate at first ser-vice (CRFS) was 1.8 (±1.4), 55, and 58%, respectively. The overall mean for the waiting period (WP), DFLS, and days open (DO) of cows was 109 (±52), 133 (±114), and 242 (±129) days, respectively. The mean for NSC, CR, and CRFS was 4.3 (±2.7), 23, and 14%, respectively. A very sig- nificant decrease in AFS and AC according to the year of birth, and a significant increase in AFS according to body weight at first insemination (>320 kg) were observed. The CRFS of heifers inseminated in 2013 was significantly higher than in 2014. Monthly mean CR in heifers and cows was negatively correlated with THI. The WP, DFLS, DO, and NSC of cows significantly decreased according to the year of calving. Cows that calved in rainy season had a significant-ly longer WP than in dry season. The occurrence of postpar-tum (PP) diseases was accompanied by an increase in WP, DO, and NSC. A decrease in body condition score (BCS) between calving and 60th day (C60) and also between 60th and 120th day of lactation resulted in a significant increase in WP and DO. A decrease in BCS between C60 was also ac-companied by a considerable reduction in CRFS of cows. Season and BCS at insemination had a significant effect on NSC and CR of cows. Reproductive performance was satis-factory for heifers, but poor for cows. Losses of BCS during the first months of lactation and at insemination were the major risk factors for this poor performance. Moreover, the season had a more negative effect on fertility in cows than in heifers. [less ▲]

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See detailStability-based validation of dietary patterns obtained by cluster analysis
Sauvageot, Nicolas ULg; Schritz, Anna; Alkerwi, Ala'a et al

in Nutrition Journal (2017), 16(3),

Abstract Background Cluster analysis is a data-driven method used to create clusters of individuals sharing similar dietary habits. However, this method requires specific choices from the user which have ... [more ▼]

Abstract Background Cluster analysis is a data-driven method used to create clusters of individuals sharing similar dietary habits. However, this method requires specific choices from the user which have an influence on the results. Therefore, there is a need of an objective methodology helping researchers in their decisions during cluster analysis. The objective of this study was to use such a methodology based on stability of clustering solutions to select the most appropriate clustering method and number of clusters for describing dietary patterns in the NESCAV study (Nutrition, Environment and Cardiovascular Health), a large population-based cross-sectional study in the Greater Region (N = 2298). Methods Clustering solutions were obtained with K-means, K-medians and Ward’s method and a number of clusters varying from 2 to 6. Their stability was assessed with three indices: adjusted Rand index, Cramer’s V and misclassification rate. Results The most stable solution was obtained with K-means method and a number of clusters equal to 3. The “Convenient” cluster characterized by the consumption of convenient foods was the most prevalent with 46% of the population having this dietary behaviour. In addition, a “Prudent” and a “Non-Prudent” patterns associated respectively with healthy and non-healthy dietary habits were adopted by 25% and 29% of the population. The “Convenient” and “Non-Prudent” clusters were associated with higher cardiovascular risk whereas the “Prudent” pattern was associated with a decreased cardiovascular risk. Associations with others factors showed that the choice of a specific dietary pattern is part of a wider lifestyle profile. Conclusion This study is of interest for both researchers and public health professionals. From a methodological standpoint, we showed that using stability of clustering solutions could help researchers in their choices. From a public health perspective, this study showed the need of targeted health promotion campaigns describing the benefits of healthy dietary patterns. [less ▲]

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See detailMicrobiological load of edible insects found in Belgium
Caparros Megido, Rudy ULg; Desmedt, Sandrine; Blecker, Christophe ULg et al

in Insects (2017)

Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are ... [more ▼]

Edible insects are gaining more and more attention as a sustainable source of animal protein for food and feed in the future. In Belgium, some insect products can be found on the market, and consumers are sourcing fresh insects from fishing stores or towards traditional markets to find exotic insects that are illegal and not sanitarily controlled. From this perspective, this study aims to characterize the microbial load of edible insects found in Belgium (i.e., fresh mealworms and house crickets from European farms and smoked termites and caterpillars from a traditional Congolese market) and to evaluate the efficiency of different processing methods (blanching for all species and freeze-drying and sterilization for European species) in reducing microorganism counts. All untreated insect samples had a total aerobic count higher than the limit for fresh minced meat (6.7 log cfu/g). Nevertheless, a species-dependent blanching step has led to a reduction of the total aerobic count under this limit, except for one caterpillar species. Freeze-drying and sterilization treatments on European species were also effective in reducing the total aerobic count. Yeast and mold counts for untreated insects were above the Good Manufacturing Practice limits for raw meat, but all treatments attained a reduction of these microorganisms under this limit. These results confirmed that fresh insects, but also smoked insects from non-European trades, need a cooking step (at least composed of a first blanching step) before consumption. Therefore, blanching timing for each studied insect species is proposed and discussed. [less ▲]

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See detailAtypical composition and structure of the mitochondrial dimeric ATP synthase from Euglena gracilis
Yadav, K.N. Sathish; Miranda Astudillo, Héctor Vicente ULg; Colina-Tenorio, Lili et al

in Biochimica et Biophysica Acta-Bioenergetics (2017), 1858(4), 267-275

Mitochondrial respiratory-chain complexes from Euglenozoa comprise classical subunits described in other eukaryotes (i.e. mammals and fungi) and subunits that are restricted to Euglenozoa (e.g. Euglena ... [more ▼]

Mitochondrial respiratory-chain complexes from Euglenozoa comprise classical subunits described in other eukaryotes (i.e. mammals and fungi) and subunits that are restricted to Euglenozoa (e.g. Euglena gracilis and Trypanosoma brucei). Here we studied the mitochondrial F1FO-ATP synthase (or Complex V) from the photosynthetic eukaryote E. gracilis in detail. The enzyme was purified by a two-step chromatographic procedure and its subunit composition was resolved by a three-dimensional gel electrophoresis (BN/SDS/SDS). Twenty-two different subunits were identified by mass-spectrometry analyses among which the canonical alpha, beta, gamma, delta, epsilon and OSCP subunits, and at least seven subunits previously found in Trypanosoma. The ADP/ATP carrier was also associated to the ATP synthase into a dimeric ATP synthasome. Single-particle analysis by transmission electron microscopy of the dimeric ATP synthase indicated that the structures of both the catalytic and central rotor parts are conserved while other structural features are original. These new features include a large membrane-spanning region joining the monomers, an external peripheral stalk and a structure that goes through the membrane and reaches the inter membrane space below the c-ring, the latter having not been reported for any mitochondrial F-ATPase. [less ▲]

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See detailWhat is the use of shaping a tang? Tool use and hafting of tanged tools in the Aterian of Northern Africa
Tomasso, Sonja ULg; Rots, Veerle ULg

in Archaeological and Anthropological sciences (2017)

We present the results of detailed microscopic examination of tanged tools from the site of Ifri n'Ammar. The rock shelter has a particularly rich and well-preserved stratigraphy that has yielded a large ... [more ▼]

We present the results of detailed microscopic examination of tanged tools from the site of Ifri n'Ammar. The rock shelter has a particularly rich and well-preserved stratigraphy that has yielded a large variety of tanged tools, thus offering a possibility to test hypotheses on the possible links between tangs and hafting. Earlier methodological work has demonstrated that patterned wear forms on the non-active part of the tool as the result of hafted tool use, and that the characteristics of the wear traces depend on the exact hafting arrangement used. In the present study, wear analyses were combined with further experiments that involved the hafting of tanged tools with various materials and arrangements and aimed at understanding the development of this important morphological innovation. We suggest that functional data are needed to understand the relevance of the "Aterian tang" for hafting (or use), and whether this innovation was triggered by functional, cultural or environmental factors. [less ▲]

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See detailPrevalence, location and concurrent diseases of ultrasonographic cyst-like lesions of abdominal lymph nodes in dogs.
Liotta, Annalisa Pia; Billen, Frédéric ULg; Heimann, Marianne et al

in The Veterinary record (2017)

Lymph nodal cyst-like lesions are occasionally identified during abdominal ultrasound in dogs. However, a study evaluating their prevalence and clinical significance is lacking. The aim of this ... [more ▼]

Lymph nodal cyst-like lesions are occasionally identified during abdominal ultrasound in dogs. However, a study evaluating their prevalence and clinical significance is lacking. The aim of this observational cross-sectional study was to evaluate prevalence, most common location and concurrent diseases of cyst-like lymph nodes detected during abdominal ultrasound. Affected lymph nodes, patient signalment and concurrent diseases of dogs with cyst-like lymph nodal lesions having undergone abdominal ultrasound over a one-year period were recorded. Twenty-three affected lymph nodes were observed in 17/553 dogs (prevalence=3 per cent). The most commonly affected was the lumbar lymphocenter (7/23), followed by the coeliac (6/23), the cranial mesenteric (5/23) and the iliosacral (5/23). Twenty-three concurrent diseases were diagnosed in 17 dogs, among which 16/23 were non-neoplastic (70 per cent). The most common concurrent disease was renal insufficiency (8/23), followed by neoplasia (7/23), gastroenteropathy (3/23), benign prostatic disease (2/23), pancreatitis (1/23), peritonitis (1/23) and neurological disease (1/23). No statistical correlation existed between cyst-like lymph nodal lesion and a specific neoplastic or non-neoplastic disease. In conclusion, in the present study, cyst-like lymph nodal lesions have a low prevalence, involve different lymphocenters and were found in dogs affected by different diseases, including both non-neoplastic and neoplastic aetiologies. [less ▲]

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See detailElevated carbon dioxide concentration reduces alarm signaling in aphids
Boullis, Antoine ULg; Fassotte, Bérénice ULg; Sarles, Landry ULg et al

in Journal of Chemical Ecology (2017), 43

Insects often rely on olfaction to communicate with surrounding conspecifics. While the chemical language of insects has been deciphered in recent decades, few studies have assessed how changes in ... [more ▼]

Insects often rely on olfaction to communicate with surrounding conspecifics. While the chemical language of insects has been deciphered in recent decades, few studies have assessed how changes in atmospheric greenhouse gas concentrations will impact pheromonal communication by insects. Here, we hypothesize that changes in the concentration of atmospheric carbon dioxide (CO2) affect the whole dynamics of alarm signaling in aphids, including: (1) the production of the active compound (E)-β-farnesene (Eβf), (2) emission behavior when under attack, (3) perception by the olfactory apparatus, and (4) the escape response. We reared two strains of the pea aphid Acyrthosiphon pisum under ambient and elevated CO2 concentrations for several generations. We found that an increase in CO2 concentration reduced the production (i.e., individual content) and emission of Eβf (released under predation events). While no difference in Eβf neuronal perception was observed, we found that an increase in CO2 strongly reduces the escape behavior expressed by an aphid colony following exposure to natural doses of the alarm pheromone. In conclusion, our results confirm that changes to greenhouse gases do impact chemical communication in insects, and could potentially have a cascade effect on interactions with higher trophic levels. [less ▲]

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See detailFermi-LAT kills dark matter interpretations of AMS-02 data. Or not?
Belotsky, Konstantin; Budaev, Ruslan; Kirillov, Alexander et al

in Journal of Cosmology and Astroparticle Physics (2017)

A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma ... [more ▼]

A number of papers attempt to explain the positron anomaly in cosmic rays, observed by PAMELA and AMS-02, in terms of dark matter (DM) decays or annihilations. However, the recent progress in cosmic gamma-ray studies challenges these attempts. Indeed, as we show, any rational DM model explaining the positron anomaly abundantly produces final state radiation and Inverse Compton gamma rays, which inevitably leads to a contradiction with Fermi-LAT isotropic diffuse gamma-ray background measurements. Furthermore, the Fermi-LAT observation of Milky Way dwarf satellites, supposed to be rich in DM, revealed no significant signal in gamma rays. We propose a generic approach in which the major contribution to cosmic rays comes from the dark matter disc and prove that the tension between the DM origin of the positron anomaly and the cosmic gamma-ray observations can be relieved. We consider both a simple model, in which DM decay/annihilate into charged leptons, and a model-independent minimal case of particle production, and we estimate the optimal thickness of DM disk. Possible mechanisms of formation and its properties are briefly discussed. [less ▲]

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See detailSimultaneous anionic ring-opening and condensation reactions for the synthesis of aliphatic–N-alkyl aromatic copolyamides
Bakkali-Hassani, Camille; Tunc, Deniz; Roos, Kevin et al

in Macromolecules (2017), 50(1), 175-181

The copolymerization of ε-caprolactam with ethyl 4-(butylamino)benzoate was shown to occur in the presence of sodium salts and an acyllactam as activator in a one-step bulk reaction. The mechanism is ... [more ▼]

The copolymerization of ε-caprolactam with ethyl 4-(butylamino)benzoate was shown to occur in the presence of sodium salts and an acyllactam as activator in a one-step bulk reaction. The mechanism is based on the deprotonation of the two monomers yielding activated species able to attack an acyllactam or an ester group at the polymer chain ends. Novel copolyamides with different percentages of aromatic/aliphatic units were synthesized in a one-step bulk copolymerization within a few minutes at 140 °C and characterized by NMR spectroscopy, size exclusion chromatography, and thermal analysis (DSC). This methodology, combining simultaneous anionic ring-opening and condensation reactions, affords a new synthetic pathway to introduce an aromatic unit in an aliphatic polyamide backbone, and more specifically a polyamide 6 containing about 20 mol % of N-alkyl aromatic amides was prepared. [less ▲]

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See detailEffect of extraction pH on techno-functional properties of crude extracts from wild cardoon (Cynara cardunculus L.) flowers
Ben Amira, Amal ULg; Makhlouf, Ines; Petrut, Raul Flaviu et al

in Food Chemistry (2017), 225

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See detailBiocompatibility of polymer-infiltrated-ceramicnetwork (PICN) materials with Human Gingival Keratinocytes (HGKs)
GRENADE, Charlotte ULg; Gillet, Marie-Claire ULg; PIRARD, Catherine ULg et al

in Dental Materials (2017), 33

Objective. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD–CAM composites, is poorly explored in the literature, in particular, no data are available regarding ... [more ▼]

Objective. Biocompatibility of polymer-infiltrated-ceramic-network (PICN) materials, a new class of CAD–CAM composites, is poorly explored in the literature, in particular, no data are available regarding Human Gingival Keratinocytes (HGK). The first objective of this study was to evaluate the in vitro biocompatibility of PICNs with HGKs in comparison with other materials typically used for implant prostheses. The second objective was to correlate results with PICN monomer release and indirect cytotoxicity. Methods. HGK attachment, proliferation and spreading on PICN, grade V titanium (Ti), yttrium zirconia (Zi), lithium disilicate glass-ceramic (eM) and polytetrafluoroethylene (negative control) discs were evaluated using a specific insert-based culture system. For PICN and eM samples, monomer release in the culture medium was quantified by high performance liquid chromatography and indirect cytotoxicity tests were performed. Results. Ti and Zi exhibited the best results regarding HGK viability, number and coverage. eM showed inferior results while PICN showed statistically similar results to eM but also to Ti regarding cell number and to Ti and Zi regarding cell viability. No monomer release from PICN discs was found, nor indirect cytotoxicity, as for eM. Significance. The results confirmed the excellent behavior of Ti and Zi with gingival cells. Even if polymer based, PICN materials exhibited intermediate results between Ti–Zi and eM. These promising results could notably be explained by PICN high temperature–high pressure (HT–HP) innovative polymerization mode, as confirmed by the absence of monomer release and indirect cytotoxicity [less ▲]

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See detailFirst scattered-light images of the gas-rich debris disk around 49 Ceti
Choquet, É.; Milli, J.; Wahhaj, Z. et al

in Astrophysical Journal Letters (2017), 834(2), 12

We present the first scattered-light images of the debris disk around 49 ceti, a ~40 Myr A1 main sequence star at 59 pc, famous for hosting two massive dust belts as well as large quantities of atomic and ... [more ▼]

We present the first scattered-light images of the debris disk around 49 ceti, a ~40 Myr A1 main sequence star at 59 pc, famous for hosting two massive dust belts as well as large quantities of atomic and molecular gas. The outer disk is revealed in reprocessed archival Hubble Space Telescope NICMOS F110W images, as well as new coronagraphic H band images from the Very Large Telescope SPHERE instrument. The disk extends from 1.1" (65 AU) to 4.6" (250 AU), and is seen at an inclination of 73degr, which refines previous measurements at lower angular resolution. We also report no companion detection larger than 3 M_Jup at projected separations beyond 20 AU from the star (0.34"). Comparison between the F110W and H-band images is consistent with a grey color of 49 ceti's dust, indicating grains larger than >2microns. Our photometric measurements indicate a scattering efficiency / infrared excess ratio of 0.2-0.4, relatively low compared to other characterized debris disks. We find that 49 ceti presents morphological and scattering properties very similar to the gas-rich HD 131835 system. From our constraint on the disk inclination we find that the atomic gas previously detected in absorption must extend to the inner disk, and that the latter must be depleted of CO gas. Building on previous studies, we propose a schematic view of the system describing the dust and gas structure around 49 ceti and hypothetic scenarios for the gas nature and origin. [less ▲]

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See detailRe-emergence of the Schmallenberg virus associated triad hydranencephaly-micromyelia-arthrogryposis in a newborn calf in Belgium, 2016
Bayrou, Calixte ULg; Garigliany, Mutien-Marie ULg; Cassart, Dominique ULg et al

in Veterinary Record Case Reports (2017), 4(1), 000342

Schmallenberg virus (SBV) emerged in Germany in 2011, then spread rapidly across Europe, causing an epizootic outbreak of abortion, stillbirth and birth at term of lambs, kids and calves with neurological ... [more ▼]

Schmallenberg virus (SBV) emerged in Germany in 2011, then spread rapidly across Europe, causing an epizootic outbreak of abortion, stillbirth and birth at term of lambs, kids and calves with neurological signs and/or musculo-skeletal malformations. SBV-associated disease in newborns disappeared in Belgium in 2013. Here, we describe a SBV genomic RNA-positive malformed calf born in May 2016. It reveals the return of SBV circulation during the fall 2015 in the said area. [less ▲]

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See detailThe soundscape of Arctic Charr spawning grounds in lotic and lentic environments: can passive acoustic monitoring be used to detect spawning activities?
Bolgan, Marta ULg; O'Brien, Joanne; Chorazyczewska, Emilia et al

in Bioacoustics (2017)

The aims of this study were to (i) assess the efficacy of passive acoustic monitoring (PAM) for detecting Arctic Charr at their spawning grounds and (ii) characterize the overall acoustic soundscape of ... [more ▼]

The aims of this study were to (i) assess the efficacy of passive acoustic monitoring (PAM) for detecting Arctic Charr at their spawning grounds and (ii) characterize the overall acoustic soundscape of these sites. PAM was carried out over three Arctic Charr spawning grounds in the UK, one lotic and two lentic. 24-h cycles of recordings were collected prior to and during the Arctic Charr spawning season, which was determined from data returns by simultaneous net monitoring. Acoustic analysis consisted of manual quantification of sound sources, Acoustic Complexity Index (ACI) calculation and spectral analysis in 1/3 octave band (SPL; dB re 1 μPa). In the lotic spawning ground, prior to the beginning of Arctic Charr spawning, SPL and ACI showed a restricted range of variation throughout the 24-h, while during spawning the night values of SPL and ACI were found to significantly increase, concurrently with the rate of gravel noise induced by fish spawning activities and fish air passage sounds. Both prior to and during the Arctic Charr run, the lentic soundscape was characterized by diel variation due to the daytime presence of anthropogenic noise and the night-time presence of insect calls, while only a few occurrences of fish air passage sounds and gravel noise were recorded. These findings suggest that PAM over Arctic Charr spawning grounds could provide meaningful information to be used in developing management plans for this threatened species, such as determining the location and time of arrival, diel pattern and length of spawning activities. [less ▲]

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See detailFlow boiling heat transfer and pressure drop characteristics of R134a, R1234yf and R1234ze in a plate heat exchanger for organic Rankine cycle units
Zhang, Ji; Desideri, Adriano ULg; Ryhl Kaern, Martin et al

in International Journal of Heat & Mass Transfer (2017), 108

The optimal design of the evaporator is one of the key issues to improve the efficiency and economics of organic Rankine cycle units. The first step in studying the evaporator design is to understand the ... [more ▼]

The optimal design of the evaporator is one of the key issues to improve the efficiency and economics of organic Rankine cycle units. The first step in studying the evaporator design is to understand the thermal- hydraulic performance of the working fluid in the evaporator of organic Rankine cycles. This paper is aimed at obtaining flow boiling heat transfer and pressure drop characteristics in a plate heat exchanger under the working conditions prevailing in the evaporator of organic Rankine cycle units. Two hydroflu- oroolefins R1234yf and R1234ze, and one hydrofluorocarbon R134a, were selected as the working fluids. The heat transfer coefficients and pressure drops of the three working fluids were measured with varying saturation temperatures, mass fluxes, heat fluxes and outlet vapour qualities, which range from 60 C to 80 C, 86 kg/m2 s to 137 kg/m2 s, 9.8 kW/m2 to 36.8 kW/m2 and 0.5 to 1, respectively. The working con- ditions covered relatively high saturation temperatures (corresponding reduced pressures of 0.35–0.74), which are prevailing in organic Rankine cycles yet absent in the open literature. The experimental data were compared with existing correlations, and new correlations were developed that are more suitable for evaporation in organic Rankine cycles. The experimental results indicate that heat transfer coefficients are strongly dependent upon the heat flux and saturation temperature. Moreover, the results suggest bet- ter thermal-hydraulic performance for R1234yf than the other two working fluids at the same saturation temperatures. With the new heat transfer and pressure drop correlations, agreements within ±25% were obtained for experimental data in similar experiments with high saturation temperatures. [less ▲]

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See detailPollen nutrients better explain bumblebee colony development than pollen diversity
Moerman, Romain; Vanderplanck, Maryse ULg; Fournier, Denis et al

in Insect Conservation and Diversity (2017)

1. Bumblebees are valuable pollinators of numerous wild and cultivated plants. They can forage on variable pollen resources. As some pollen species lack particular nutrients or have global low nutritional ... [more ▼]

1. Bumblebees are valuable pollinators of numerous wild and cultivated plants. They can forage on variable pollen resources. As some pollen species lack particular nutrients or have global low nutritional quality, it has been suggested that bumblebees mix their pollen incomes to ensure a global balanced diet. The hypothesis that a mixed pollen diet better supports bumblebee colony development than a single pollen diet has been poorly explored. 2. We compared the impact of mono-, di- and trifloral diets on microcolony development of Bombus terrestris using three pollen resources with different nutrient contents (Cytisus scoparius, Erica sp. and Sorbus aucuparia) as well as their mixes. Nine parameters (e.g. pollen efficacy: total weight of larvae/total weight of pollen collection) were used to compare the microcolony performances. Moreover, we measured the influence of the pollen diversity and nutritional composition on relevant parameters. 3. We showed that microcolonies can potentially better develop on mixed pollen diets, but single pollen diet can also be as good as mixed pollen diet. Moreover, the sterol concentration appeared as a key factor to establish the impact of a pollen diet on the bumblebee colony development. 4. This study reveals that diverse pollen diet does not necessary equate with good colony development and supports the importance of selecting floral resources by considering their nutrient contents for bee conservation management. [less ▲]

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See detailStromal Modulators of TGF-β in Cancer
Costanza, Brunella ULg; Umelo, Ijeoma ULg; Bellier, Justine ULg et al

in Journal of clinical Medicine (2017)

Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand ... [more ▼]

Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers [less ▲]

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See detailSodium vanadium (III) fluorophosphate/carbon nanotubes composite (NVPF/CNT) prepared by spray-drying: good electrochemical performance thanks to well-dispersed CNT network within NVPF particles
Eshraghi, Nicolas ULg; Caes, Sebastien; Mahmoud, Abdelfattah ULg et al

in Electrochimica Acta (2017), 228

We successfully prepared NASICON-type Na3V2(PO4)2F3 (NVPF) and a Na3V2(PO4)2F3/carbon nanotubes (CNT) composite by spray-drying followed by heat treatment in argon for 2 hours at 600 °C. The addition of ... [more ▼]

We successfully prepared NASICON-type Na3V2(PO4)2F3 (NVPF) and a Na3V2(PO4)2F3/carbon nanotubes (CNT) composite by spray-drying followed by heat treatment in argon for 2 hours at 600 °C. The addition of CNT in the spray-drying solution creates a CNT network within the NVPF particles. After grinding, the smaller NVPF particles remain linked by CNT. Thanks to this conducting network, the composite powder displays competitive electrochemical performance when cycled against lithium in hybrid-ion batteries (2–4.6 V vs. Li+/Li) with specific capacities of 125 mAh.g−1 at C/10, 103 mAh.g−1 at 1C and 91 mAh.g−1 at 4C, together with 97.5% capacity retention at 1C over 100 cycles with coulombic efficiency of 99.4%. These results demonstrate that sodium vanadium (III) fluorophosphate electrode material can be obtained in a time-efficient way using the easily up-scalable spray-drying method. [less ▲]

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See detailA Framework for the Evaluation of Biosecurity, Commercial, Regulatory, and Scientific Impacts of Plant Viruses and Viroids Identified by NGS Technologies
Massart, Sebastien; Candresse, Thierry; Gil, Jose et al

in Frontiers in Microbiology (2017), 8(45),

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See detailCompte rendu de Lavocat (Françoise), Fait et fiction, Paris, Seuil, "Poétique", 2016, 618p.
Huppe, Justine ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2017)

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See detailImage quality in Coronary CT Angiography: Challenges and technical solutions.
Ghekiere, Olivier; Salgado, Rodrigo; Buls, Nico et al

in British Journal of Radiology (2017)

Multidetector CT angiography has become a widely accepted examination for non-invasive evaluation of the heart and coronary arteries. Despite its ongoing success and worldwide clinical implementation, it ... [more ▼]

Multidetector CT angiography has become a widely accepted examination for non-invasive evaluation of the heart and coronary arteries. Despite its ongoing success and worldwide clinical implementation, it remains an often-challenging procedure in which image quality, and hence diagnostic value, is determined by both technical and patient-related factors. Thorough knowledge of these factors is important to obtain high quality examinations. In this review, we discuss several key elements that may adversely affect coronary CT angiography image quality as well as potential measures that can be taken to mitigate their impact. In addition, several recent vendor-specific advances and future directions to improve image quality are discussed. [less ▲]

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See detailSegregation and pattern formation in dilute granular media under microgravity conditions
Opsomer, Eric ULg; Noirhomme, Martial ULg; Vandewalle, Nicolas ULg et al

in NPJ Microgravity (2017), 3

Space exploration and exploitation face a major challenge: the handling of granular materials in low-gravity environments. Indeed, grains behave quite differently in space than on Earth, and the ... [more ▼]

Space exploration and exploitation face a major challenge: the handling of granular materials in low-gravity environments. Indeed, grains behave quite differently in space than on Earth, and the dissipative nature of the collisions between solid particles leads to clustering. Within poly-disperse materials, the question of segregation is highly relevant but has not been addressed so far in microgravity. From parabolic flight experiments on dilute binary granular media, we show that clustering can trigger a segregation mechanism, and we observe, for the first time, the formation of layered structures in the bulk. [less ▲]

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See detailOptimal measurement counting time and statistics in gamma spectrometry analysis: The time balance
Guembou Shouop, Cébastien Joel ULg; Penabei, Samafou; Ndontchueng Moyo, Maurice et al

in American Institute of Physics (2017), 1797

The optimal measurement counting time for gamma-ray spectrometry analysis using HPGe detectors was determined in our laboratory by comparing twelve hours measurement counting time at day and twelve hours ... [more ▼]

The optimal measurement counting time for gamma-ray spectrometry analysis using HPGe detectors was determined in our laboratory by comparing twelve hours measurement counting time at day and twelve hours measurement counting time at night. The day spectrum does not fully cover the night spectrum for the same sample. It is observed that the perturbation come to the sun-light. After several investigations became clearer: to remove all effects of radiation from outside (earth, the sun, and universe) our system, it is necessary to measure the background for 24, 48 or 72 hours. In the same way, the samples have to be measured for 24, 48 or 72 hours to be safe to be purified the measurement (equality of day and night measurement). It is also possible to not use the background of the winter in summer. Depend on to the energy of radionuclide we seek, it is clear that the most important steps of a gamma spectrometry measurement are the preparation of the sample and the calibration of the detector. [less ▲]

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See detailCharacterization of the inner disk around HD 141569 A from Keck/NIRC2 L-band vortex coronagraphy
Mawet, Dimitri; Choquet, Élodie; Absil, Olivier ULg et al

in Astronomical Journal (The) (2017), 153(1), 44

HD 141569 A is a pre-main sequence B9.5 Ve star surrounded by a prominent and complex circumstellar disk, likely still in a transition stage from protoplanetary to debris disk phase. Here, we present a ... [more ▼]

HD 141569 A is a pre-main sequence B9.5 Ve star surrounded by a prominent and complex circumstellar disk, likely still in a transition stage from protoplanetary to debris disk phase. Here, we present a new image of the third inner disk component of HD 141569 A made in the L' band (3.8 micron) during the commissioning of the vector vortex coronagraph recently installed in the near-infrared imager and spectrograph NIRC2 behind the W.M. Keck Observatory Keck II adaptive optics system. We used reference point spread function subtraction, which reveals the innermost disk component from the inner working distance of $\simeq 23$ AU and up to $\simeq 70$ AU. The spatial scale of our detection roughly corresponds to the optical and near-infrared scattered light, thermal Q, N and 8.6 micron PAH emission reported earlier. We also see an outward progression in dust location from the L'-band to the H-band (VLT/SPHERE image) to the visible (HST/STIS image), likely indicative of dust blowout. The warm disk component is nested deep inside the two outer belts imaged by HST NICMOS in 1999 (respectively at 406 and 245 AU). We fit our new L'-band image and spectral energy distribution of HD 141569 A with the radiative transfer code MCFOST. Our best-fit models favor pure olivine grains, and are consistent with the composition of the outer belts. While our image shows a putative very-faint point-like clump or source embedded in the inner disk, we did not detect any true companion within the gap between the inner disk and the first outer ring, at a sensitivity of a few Jupiter masses. [less ▲]

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See detailThe W. M. Keck Observatory infrared vortex coronagraph and a first image of HIP79124 B
Serabyn, Eugene; Huby, Elsa ULg; Matthews, Keith et al

in Astronomical Journal (The) (2017), 153(1), 43

An optical vortex coronagraph has been implemented within the NIRC2 camera on the Keck II telescope and used to carry out on-sky tests and observations. The development of this new L'-band observational ... [more ▼]

An optical vortex coronagraph has been implemented within the NIRC2 camera on the Keck II telescope and used to carry out on-sky tests and observations. The development of this new L'-band observational mode is described, and an initial demonstration of the new capability is presented: a resolved image of the low-mass companion to HIP79124, which had previously been detected by means of interferometry. With HIP79124 B at a projected separation of 186.5 mas, both the small inner working angle of the vortex coronagraph and the related imaging improvements were crucial in imaging this close companion directly. Due to higher Strehl ratios and more relaxed contrasts in L' band versus H band, this new coronagraphic capability will enable high-contrast small-angle observations of nearby young exoplanets and disks on a par with those of shorter-wavelength extreme adaptive optics coronagraphs. [less ▲]

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See detailHow should proxies of Cognitive Reserve be evaluated in a population of healthy older adults?
Grotz, Catherine ULg; Seron, Xavier; Van Wissen, Marie et al

in International Psychogeriatrics (2017), 29(1), 123-136

Background: While some tools have been developed to estimate an individual’s cognitive reserve (CR), no study has assessed the adequacy of the method used for assessing these CR proxy indicators ... [more ▼]

Background: While some tools have been developed to estimate an individual’s cognitive reserve (CR), no study has assessed the adequacy of the method used for assessing these CR proxy indicators. Therefore, we aimed to determine the most appropriate method to estimate CR by comparing two approaches: 1) the common assessment of CR proxies in the literature (e.g., years of education) and 2) the calculation of a comprehensive index based on most significant parameters used in the estimation of CR. Methods: Data on CR proxies: (i.e., education, occupation and leisure activities) were obtained in a sample of 204 older adults. Regression analyses were used to develop the two indices of CR (i.e., ICR-standard and ICR-detailed) and to determine which index best represented the level of one’s CR. Results: The ICR-standard was calculated using a combination of the three most common measures of reserve in the literature: number of schooling years, complexity of the primary occupation and amount of current participation in stimulating activities. The ICR-detailed was calculated using the most significant parameters (established in initial analyses) of CR: highest level of education combined with the number of training courses, last occupation and amount of current participation in social and intellectual activities. The comparison of both indices showed that higher levels of ICR-standard and ICR-detailed were associated with a greater minimization of the effects of age on cognition. However, the ICR-detailed was more strongly associated to this minimization than the ICR-standard, suggesting that the ICR-detailed best reflect one’s CR. Conclusion: This study is the first to show that it is of great importance to question methods measuring CR proxies in order to develop a clinical tool allowing a comprehensive and accurate estimation of CR. [less ▲]

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See detailPaleogenetic study of ancient DNA suggestive of X-Linked acrogigantism
Beckers, Albert ULg; Fernandes, Daniel; Fina, Frederic et al

in Endocrine-Related Cancer (2017)

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See detailDiscovery of a low-mass companion inside the debris ring surrounding the F5V star HD 206893
Milli, J.; Hibon, P.; Christiaens, Valentin ULg et al

in Astronomy and Astrophysics (2017), 597

<BR /> Aims: Uncovering the ingredients and the architecture of planetary systems is a very active field of research that has fuelled many new theories on giant planet formation, migration, composition ... [more ▼]

<BR /> Aims: Uncovering the ingredients and the architecture of planetary systems is a very active field of research that has fuelled many new theories on giant planet formation, migration, composition, and interaction with the circumstellar environment. We aim at discovering and studying new such systems, to further expand our knowledge of how low-mass companions form and evolve. <BR /> Methods: We obtained high-contrast H-band images of the circumstellar environment of the F5V star HD 206893, known to host a debris disc never detected in scattered light. These observations are part of the SPHERE High Angular Resolution Debris Disc Survey (SHARDDS) using the InfraRed Dual-band Imager and Spectrograph (IRDIS) installed on VLT/SPHERE. <BR /> Results: We report the detection of a source with a contrast of 3.6 × 10[SUP]-5[/SUP] in the H-band, orbiting at a projected separation of 270 milliarcsec or 10 au, corresponding to a mass in the range 24 to 73 M[SUB]Jup[/SUB] for an age of the system in the range 0.2 to 2 Gyr. The detection was confirmed ten months later with VLT/NaCo, ruling out a background object with no proper motion. A faint extended emission compatible with the disc scattered light signal is also observed. <BR /> Conclusions: The detection of a low-mass companion inside a massive debris disc makes this system an analog of other young planetary systems such as β Pictoris, HR 8799 or HD 95086 and requires now further characterisation of both components to understand their interactions. [less ▲]

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See detailWater loss from terrestrial planets orbiting ultracool dwarfs: implications for the planets of TRAPPIST-1
Bolmont, E.; Selsis, F.; Owen, J. E. et al

in Monthly Notices of the Royal Astronomical Society (2017), 464

Ultracool dwarfs (UCD; $T_{\rm eff}<\sim3000~$K) cool to settle on the main sequence after $\sim$1 Gyr. For brown dwarfs, this cooling never stops. Their habitable zone (HZ) thus sweeps inward at least ... [more ▼]

Ultracool dwarfs (UCD; $T_{\rm eff}<\sim3000~$K) cool to settle on the main sequence after $\sim$1 Gyr. For brown dwarfs, this cooling never stops. Their habitable zone (HZ) thus sweeps inward at least during the first Gyr of their lives. Assuming they possess water, planets found in the HZ of UCDs have experienced a runaway greenhouse phase too hot for liquid water prior to entering the HZ. It has been proposed that such planets are desiccated by this hot early phase and enter the HZ as dry worlds. Here we model the water loss during this pre-HZ hot phase taking into account recent upper limits on the XUV emission of UCDs and using 1D radiation-hydrodynamic simulations. We address the whole range of UCDs but also focus on the planets recently found around the $0.08~M_\odot$ dwarf TRAPPIST-1. Despite assumptions maximizing the FUV-photolysis of water and the XUV-driven escape of hydrogen, we find that planets can retain significant amounts of water in the HZ of UCDs, with a sweet spot in the $0.04$-$0.06~M_\odot$ range. We also studied the TRAPPIST-1 system using observed constraints on the XUV-flux. We find that TRAPPIST-1b and c may have lost as much as 15 Earth Oceans and planet d -- which might be inside the HZ -- may have lost less than 1 Earth Ocean. Depending on their initial water contents, they could have enough water to remain habitable. TRAPPIST-1 planets are key targets for atmospheric characterization and could provide strong constraints on the water erosion around UCDs. [less ▲]

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See detailRossiter-McLaughlin models and their effect on estimates of stellar rotation, illustrated using six WASP systems
Brown, D. J. A.; Triaud, A. H. M. J.; Doyle, A. P. et al

in Monthly Notices of the Royal Astronomical Society (2017), 464

We present new measurements of the projected spin--orbit angle $\lambda$ for six WASP hot Jupiters, four of which are new to the literature (WASP-61, -62, -76, and -78), and two of which are new analyses ... [more ▼]

We present new measurements of the projected spin--orbit angle $\lambda$ for six WASP hot Jupiters, four of which are new to the literature (WASP-61, -62, -76, and -78), and two of which are new analyses of previously measured systems using new data (WASP-71, and -79). We use three different models based on two different techniques: radial velocity measurements of the Rossiter--McLaughlin effect, and Doppler tomography. Our comparison of the different models reveals that they produce projected stellar rotation velocities ($v \sin I_{\rm s}$) measurements often in disagreement with each other and with estimates obtained from spectral line broadening. The Bou\'e model for the Rossiter--McLaughlin effect consistently underestimates the value of $v\sin I_{\rm s}$ compared to the Hirano model. Although $v \sin I_s$ differed, the effect on $\lambda$ was small for our sample, with all three methods producing values in agreement with each other. Using Doppler tomography, we find that WASP-61\,b ($\lambda=4^\circ.0^{+17.1}_{-18.4}$), WASP-71\,b ($\lambda=-1^\circ.9^{+7.1}_{-7.5}$), and WASP-78\,b ($\lambda=-6^\circ.4\pm5.9$) are aligned. WASP-62\,b ($\lambda=19^\circ.4^{+5.1}_{-4.9}$) is found to be slightly misaligned, while WASP-79\,b ($\lambda=-95^\circ.2^{+0.9}_{-1.0}$) is confirmed to be strongly misaligned and has a retrograde orbit. We explore a range of possibilities for the orbit of WASP-76\,b, finding that the orbit is likely to be strongly misaligned in the positive $\lambda$ direction. [less ▲]

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See detailThe EACVI Echo Handbook.
Nchimi Longang, Alain ULg

in European Heart Journal (2017)

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See detailHot-Melt Extrusion as a Continuous Manufacturing Process to Form Ternary Cyclodextrin Inclusion Complexes
Thiry, Justine ULg; Krier, Fabrice; Ratwatte, Shenelka et al

in European Journal of Pharmaceutical Sciences (2017), 96

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See detailFirst limits on the occurrence rate of short-period planets orbiting brown dwarfs
He, Matthias Y.; Triaud, Amaury H. M. J.; Gillon, Michaël ULg

in Monthly Notices of the Royal Astronomical Society (2017), 464

Planet formation theories predict a large but still undetected population of short-period terrestrial planets orbiting brown dwarfs. Should specimens of this population be discovered transiting relatively ... [more ▼]

Planet formation theories predict a large but still undetected population of short-period terrestrial planets orbiting brown dwarfs. Should specimens of this population be discovered transiting relatively bright and nearby brown dwarfs, the Jupiter-size and the low luminosity of their hosts would make them exquisite targets for detailed atmospheric characterisation with JWST and future ground-based facilities. The eventual discovery and detailed study of a significant sample of transiting terrestrial planets orbiting nearby brown dwarfs could prove to be useful not only for comparative exoplanetology but also for astrobiology, by bringing us key information on the physical requirements and timescale for the emergence of life. In this context, we present a search for transit-signals in archival time-series photometry acquired by the Spitzer Space Telescope for a sample of 44 nearby brown dwarfs. While these 44 targets were not particularly selected for their brightness, the high precision of their Spitzer light curves allows us to reach sensitivities below Earth-sized planets for 75% of the sample and down to Europa-sized planets on the brighter targets. We could not identify any unambiguous planetary signal. Instead, we could compute the first limits on the presence of planets on close-in orbits. We find that within a 1.28 day orbit, the occurrence rate of planets with a radius between 0.75 and 3.25 R$_\oplus$ is {\eta} < 67 $\pm$ 1%. For planets with radii between 0.75 and 1.25 R$_\oplus$, we place a 95% confident upper limit of {\eta} < 87 $\pm$ 3%. If we assume an occurrence rate of {\eta} = 27% for these planets with radii between 0.75 and 1.25 R$_\oplus$, as the discoveries of the Kepler-42b and TRAPPIST-1b systems would suggest, we estimate that 175 brown dwarfs need to be monitored in order to guarantee (95%) at least one detection. [less ▲]

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See detailInvited Commentary
Lancellotti, Patrizio ULg; Nchimi Longang, Alain ULg

in Annals of Thoracic Surgery (2017), 103(1), 81-82

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See detailUsutu virus, Belgium, 2016
Garigliany, Mutien-Marie ULg; Linden, Annick ULg; Gilliaux, Gautier ULg et al

in Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics of Infectious Diseases (2017), 48(1), 116-119

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths ... [more ▼]

During late summer 2016, in a northwest European region extending over Belgium, the Netherlands and the eastern border of the German state of North Rhine Westphalia, an outbreak of wild bird deaths occurred similar to those reported on the continent since 1996. Dead birds were necropsied and examined by complementary methods. Pathologic and immunohistological investigations strongly suggested an infection by Usutu virus. Subsequently, genomic segments of the said virus were detected, the virus was isolated and its complete genome was sequenced. The strain, designated Usutu-LIEGE, is a close phylogenetic relative of those isolated in Germany which form a distinct group within the USUV phylogeny, the so-called Europe_3 lineage. Should this outbreak recapitulate the characteristics of those in southwest Germany in 2011 and in/around Vienna (Austria) in 2001, it is expected that specific avian populations in the affected area will face a significant reduction in size for a few years. [less ▲]

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See detailTHE LACTOPEROXIDASE SYSTEM, A NATURAL BIOCHEMICAL BIOCONTROL AGENT FOR PRE- AND POST-HARVEST APPLICATIONS
Bafort, Françoise ULg; Parisi, Olivier ULg; Perraudin, Jean-Paul et al

in Journal of Phytopathology (2017), 165(1), 22-34

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See detailMulti-approach analysis to assess diet of harbour porpoises Phocoena phocoena in the southern North Sea
Mahfouz, C.; Meziane, T.; Henry, F. et al

in Marine Ecology. Progress Series (2017), 563

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See detailCompte rendu: AXEMAN's JAZZ et DEAD MAN'S BLUES ( Ray Celestin)
Sacré, Robert ULg

in ABS Magazine (2017), (53),

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See detailCoordinated Supervisory Control of Multi-Terminal HVDC Grids: a Model Predictive Control Approach
Papangelis, Lampros ULg; Debry, Marie-Sophie; Panciatici, Patrick et al

in IEEE Transactions on Power Systems (2017)

A coordinated supervisory control scheme for future multi-terminal High-Voltage Direct-Current (HVDC) grids is proposed. The purpose is to supervise the grid and take appropriate actions to ensure power ... [more ▼]

A coordinated supervisory control scheme for future multi-terminal High-Voltage Direct-Current (HVDC) grids is proposed. The purpose is to supervise the grid and take appropriate actions to ensure power balance and prevent or remove voltage or current limit violations. First, using DC current and voltage measurements, the power references of the various Voltage Sources Converters (VSC) are updated according to participation factors. Next, the setpoints of the converters are smoothly adjusted to track those power references, while avoiding or correcting limit violations. The latter function resorts to Model Predictive Control and a sensitivity model of the system. The efficiency of the proposed scheme has been tested through dynamic simulations of a five-terminal HVDC grid interconnecting two asynchronous AC areas and a wind farm. [less ▲]

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See detailNullité et restitutions – À propos de la nullité d’une convention portant mise à disposition de travailleurs conclue en méconnaissance de la loi du 24 juillet 1987
Daumen, Laura ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2017), 2017(1), 41

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See detailMethane balance of an intensively grazed pasture and estimation of the enteric methane emissions from cattle
Dumortier, Pierre ULg; Aubinet, Marc ULg; Beckers, Yves ULg et al

in Agricultural and Forest Meteorology (2017), 232

The methane turbulent fluxes of an intensively grazed pasture were measured continuously from June 2012 to December 2013 at the Dorinne Terrestrial Observatory (DTO) in Belgium. During grazing periods ... [more ▼]

The methane turbulent fluxes of an intensively grazed pasture were measured continuously from June 2012 to December 2013 at the Dorinne Terrestrial Observatory (DTO) in Belgium. During grazing periods, the fluxes were dominated by enteric fermentation and were found to be strongly related to cow stocking density. In 2013, total emission from the pasture was found between 9 and 11 g CH4 m−2, 97% of which being emitted during grazing periods. Emission per LU (livestock unit) was estimated in a non-invasive way by integrating eddy covariance fluxes over large periods and by assuming a homogeneous average cattle disposition on the pasture. This estimate was compared to the one obtained during confinement periods, where cows were confined in a small part of the pasture. The emission per LU varied between 104 and 134 g CH4 LU−1 day−1 (13 and 17 g CH4 kg DMI−1), depending on the dataset and the computation method used. Diel course was characterized by two emission peaks, one in the morning and a larger one in the afternoon. For rest periods (no cattle on the pasture), small emissions were observed (median and mean values of 0.5 and 1.5 mg CH4 m−2 day−1, respectively). [less ▲]

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See detailSelf-Administration of Medicines and Dietary Supplements Among Female Amateur Runners: A Cross-Sectional Analysis.
Locquet, Médéa ULg; Beaudart, Charlotte ULg; Larbuisson, Robert ULg et al

in Advances in Therapy (2017), 33(12), 2257-2268

INTRODUCTION: Self-administration of medicines or dietary supplements without any physician's advice is a widespread behavior and appears to be more frequently practiced by women. Moreover, reasons to ... [more ▼]

INTRODUCTION: Self-administration of medicines or dietary supplements without any physician's advice is a widespread behavior and appears to be more frequently practiced by women. Moreover, reasons to self-administer products are often pains and injuries especially among athletes who might also use remedies to improve physical performance. The objective of this study was thus to assess the prevalence of self-administration of medicines and dietary supplements as well as its determinants among female amateur runners. METHODS: Our sample was comprised of women who took part in amateur running events. Data regarding self-administration of substances, exclusively aiming at being physically prepared for the running event (i.e., intake the week before), were collected through an anonymous self-administered questionnaire including four specific themes (i.e., general information, self-administered medicines and dietary supplements, context of self-administration of substances and knowledge of the anti-doping regulations). RESULTS: A total of 136 women, with a median age of 39 years (interquartile range: 27-47), volunteered. Among them, 34.6% reported self-administration of medicines during the period immediately preceding the running event, with the aim to be physically prepared. More than one third (33.8%) also declared self-administration of dietary supplements. Furthermore, we observed that about 8.1% of the sample had consumed a potentially doping substance. After adjustments for confounding variables, the probability of self-administration of products (medicines or supplements) increased significantly with the intensity of the activity and the membership in a sports club. CONCLUSIONS: Our study showed that self-administration of products among female runners seems to be a widespread behavior, where the intensity of the sports practice and the network of runners seem to influence the decision to resort to this behavior. [less ▲]

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See detailEtude rétrospective du bilan thyroïdien: définition de valeurs de référence pédiatriques
LADANG, Aurélie ULg; VRANKEN, Laura ULg; LUYCKX, Françoise ULg et al

in Revue Médicale de Liège (2017)

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range ... [more ▼]

Defining reference range is an essential tool for diagnostic. Age and sexe influences on thyroid hormone levels have been already discussed. In this study, we are defining a new pediatric reference range for TSH, FT3 and FT4 for Cobas C6000 analyzer. To do so, we have taken in account 0 to 18 year old outclinic patients. During the first year of life, thyroid hormone levels change dramatically before getting stabilized around 3 years old. We also compared our results to those obtained in a Canadian large-scale prospective study (the CALIPER initiative). [less ▲]

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See detailLa cigarette électronique : état des connaissances à propos des aspects toxicologiques
DEVILLE, Marine ULg; CHARLIER, Corinne ULg

in Revue Médicale de Liège (2017), 72(1), 20-24

La cigarette électronique, aussi appelée e-cigarette, est présentée comme une alternative au tabagisme qui serait moins nocive pour la santé. Son fonctionnement repose sur la conversion d’un liquide en ... [more ▼]

La cigarette électronique, aussi appelée e-cigarette, est présentée comme une alternative au tabagisme qui serait moins nocive pour la santé. Son fonctionnement repose sur la conversion d’un liquide en vapeur, sous l’action de la chaleur générée par un filament présent dans un atomiseur. Le liquide est majoritairement composé de propylène glycol et/ou de glycérine, utilisé(s) pour produire l’effet de fumée, auxquels s’ajoutent des arômes et, éventuellement, de la nicotine. A l’exception de cette dernière, potentiellement létale lorsqu’elle est ingérée à haute dose, ces constituants sont généralement reconnus comme sans danger. Cependant, les conséquences d’une inhalation chronique de propylène glycol sont méconnues. Avantageusement, les composés qui rendent la cigarette traditionnelle particulièrement nuisible – nitrosamines, formaldéhyde, métaux, monoxyde de carbone,… - sont soit absents, soit présents en faible quantité dans la vapeur d’une e-cigarette, sans comparaison avec les taux mesurés dans la fumée d’une cigarette conventionnelle. Il en résulte un profil de toxicité rassurant pour la e-cigarette, bien que son efficacité dans le sevrage tabagique reste à démontrer. [less ▲]

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