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See detailCompeting effects of volume change and water uptake on the water retention behaviour of a compacted MX-80 bentonite/sand mixture
Gatabin, Claude; Talandier, Jean; Collin, Frédéric ULg et al

in Applied Clay Science (2016), 121-122

Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first ... [more ▼]

Bentonite-based materials have been studied as potential barriers for the geological disposal of radioactive waste. In this context, the hydro-mechanical behaviour of the engineered barrier is first characterized by free swelling conditions (as a consequence of the progressive filling of technological gaps) followed by constant volume conditions. This paper presents an experimental study conducted in order to characterize the water retention behaviour of a compacted MX-80 bentonite/sand mixture. The water retention properties upon wetting were investigated under both free swelling and constant volume conditions. In the high suction range, the water content was not influenced by the imposed volume constraints. On the contrary, swelling significantly affected the water retention behaviour at low suctions, and the quantity of water stored was higher under free swelling conditions than it was under prevented swelling. In this case, competing effects between bentonite swelling and water uptake did not lead to an increase of the degree of saturation upon wetting, as it was observed for samples wetted under constant volume conditions. The influence of the very strong hydro-mechanical coupling is further discussed. [less ▲]

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See detailCombined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
Hochberg, M. C.; Martel-Pelletier, J.; Monfort, J. et al

in Ann Rheum Dis (2016), 75(1), 37-44

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind ... [more ▼]

OBJECTIVES: To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain. METHODS: Double-blind Multicentre Osteoarthritis interVEntion trial with SYSADOA (MOVES) conducted in France, Germany, Poland and Spain evaluating treatment with CS+GH versus celecoxib in 606 patients with Kellgren and Lawrence grades 2-3 knee osteoarthritis and moderate-to-severe pain (Western Ontario and McMaster osteoarthritis index (WOMAC) score >/=301; 0-500 scale). Patients were randomised to receive 400 mg CS plus 500 mg GH three times a day or 200 mg celecoxib every day for 6 months. The primary outcome was the mean decrease in WOMAC pain from baseline to 6 months. Secondary outcomes included WOMAC function and stiffness, visual analogue scale for pain, presence of joint swelling/effusion, rescue medication consumption, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria and EuroQoL-5D. RESULTS: The adjusted mean change (95% CI) in WOMAC pain was -185.7 (-200.3 to -171.1) (50.1% decrease) with CS+GH and -186.8 (-201.7 to -171.9) (50.2% decrease) with celecoxib, meeting the non-inferiority margin of -40: -1.11 (-22.0 to 19.8; p=0.92). All sensitivity analyses were consistent with that result. At 6 months, 79.7% of patients in the combination group and 79.2% in the celecoxib group fulfilled OMERACT-OARSI criteria. Both groups elicited a reduction >50% in the presence of joint swelling; a similar reduction was seen for effusion. No differences were observed for the other secondary outcomes. Adverse events were low and similarly distributed between groups. CONCLUSIONS: CS+GH has comparable efficacy to celecoxib in reducing pain, stiffness, functional limitation and joint swelling/effusion after 6 months in patients with painful knee osteoarthritis, with a good safety profile. TRIAL REGISTRATION NUMBER: NCT01425853. [less ▲]

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See detailTowards Generic Image Classification using Tree-based Learning: an Extensive Empirical Study
Marée, Raphaël ULg; Geurts, Pierre ULg; Wehenkel, Louis ULg

in Pattern Recognition Letters (2016)

This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are ... [more ▼]

This paper considers the general problem of image classification without using any prior knowledge about image classes. We study variants of a method based on supervised learning whose common steps are the extraction of random subwindows described by raw pixel intensity values and the use of ensemble of extremely randomized trees to directly classify images or to learn image features. The influence of method parameters and variants is thoroughly evaluated so as to provide baselines and guidelines for future studies. Detailed results are provided on 80 publicly available datasets that depict very diverse types of images (more than 3800 image classes and over 1.5 million images). [less ▲]

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See detailParsimonious time series clustering using P-splines
Iorio, Carmela; Frasso, Gianluca ULg; D’Ambrosio, Antonio et al

in Expert Systems with Applications (2016)

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available ... [more ▼]

Abstract We introduce a parsimonious model-based framework for clustering time course data. In these applications the computational burden becomes often an issue due to the large number of available observations. The measured time series can also be very noisy and sparse and an appropriate model describing them can be hard to define. We propose to model the observed measurements by using P-spline smoothers and then to cluster the functional objects as summarized by the optimal spline coefficients. According to the characteristics of the observed measurements, our proposal can be combined with any suitable clustering method. In this paper we provide applications based on non-hierarchical clustering algorithms. We evaluate the accuracy and the efficiency of our proposal by simulations and by analyzing two real data examples. [less ▲]

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See detailHearing “quack” and remembering a duck: Evidence for fluency attribution in young children
Geurten, Marie ULg; Lloyd, Marianne; Willems, Sylvie ULg

in Child Development (2016)

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and ... [more ▼]

Previous research has suggested that fluency does not influence memory decisions until age 7-8. In two experiments (n=96 and n=64, respectively), children, aged 4, 6, and 8 years (Experiment 1-2), and adults (Experiment 2) studied a list of pictures. Participants completed a recognition test during which each study item was preceded by a sound providing either a highly predictive or mildly predictive context in order to make some test items more conceptually fluent. Overall, highly predictive items were recognized at a higher rate than mildly predictive items demonstrating an earlier development of the fluency heuristic than previously observed. The study provides insight on how children develop metacognitive expectations and when they start to use them to guide their memory responses. [less ▲]

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See detailStructured carbons as supports for hydrogenation hybrid catalysts prepared by the immobilization of a Rh diamine complex
Gheorghiu, Cristina; Garcia-Bordeje, Enrique; Job, Nathalie ULg et al

in Chemical Engineering Journal (2016), 291

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See detailThe radial artery for coronary artery bypass grafting: a second revival?
Sousa Uva, Miguel; Kolh, Philippe ULg

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 49(1), 210-1

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See detailRisk factors and effect of selective removal on retroviral infections prevalence in Belgian stray cats.
Garigliany, Mutien-Marie ULg; Jolly, Sandra ULg; Dive, M. et al

in The Veterinary record (2016), 178(2), 45

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in ... [more ▼]

The aim of this study was to evaluate the effect of several risk/protective factors and predictors on the prevalence of feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV) infections in 302 stray cats captured during a trap-neuter-release programme in a mixed urban-rural area from Belgium, from 2010 to 2012. The impact of selective removal of FIV-positive cats on the apparent prevalence in the remaining population over this three-year period was also assessed. The seroprevalences over three years were 18.8 per cent for FIV and 0.7 per cent for FeLV. For FIV, the seroprevalence decreased significantly from the first year of the programme (2010; 30.5 per cent) to the last (2012; 13.1 per cent). Sex (male) and age (adult and old cats) were risk factors, while the year of sampling (years 2011 and 2012) was a protective factor. Age, sex and location were the most relevant predictors of FIV status. The data presented in this study revealed a very high FIV seroprevalence in Belgian stray cats, while FeLV was almost absent. The selective removal of positive cats had a drastic effect on the FIV seroprevalence in the remaining cat population. [less ▲]

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See detailEffect of wheel traffic on the physical properties of a Luvisol
Destain, Marie-France ULg; Roisin, Christian; Dalcq, Anne-Catherine ULg et al

in Geoderma (2016)

The effects of machine traffic were assessed on a Luvisol in a temperate climate area in Belgium. Soil samples were taken from topsoil (0.07-0.25 m) and subsoil (0.35-0.50 m), on plots under long-term ... [more ▼]

The effects of machine traffic were assessed on a Luvisol in a temperate climate area in Belgium. Soil samples were taken from topsoil (0.07-0.25 m) and subsoil (0.35-0.50 m), on plots under long-term reduced tillage (RT) and conventional tillage (CT). Cone index (CI), bulk density (BD) and precompression stress (Pc) were chosen as indicators of mechanical strength. Mercury intrusion porosimetry was used to characterize the soil microporosity structure. It was presented in two forms: (i) cumulative pore volume vs. equivalent pore radius r, from which four classes of porosity were defined: r < 0.2 μm, 0.2 ≤ r < 9 µm, 9 ≤ r < 73 µm and r ≥ 73 μm; (ii) pore-size distribution (PSDs). In the reference situation where there had been no recent passage of machines, the voids with 0.2 ≤ r < 9 µm were the most important class in RT topsoil. The voids with r ≥ 73 µm represented the main porosity class in the topsoil of CT. In the subsoil, for both tillage systems, the porosity was almost equally distributed between voids with 0.2 ≤ r < 9 µm and voids with r greater than 9 µm. Machine traffic was carried out when the soil water content was close to the optimum Proctor. Although unfavourable, these wet conditions often occur during the beet harvesting period in Belgium. The highest modifications in soil structure (increase in BD and Pc, reduction of macroporosity r ≥ 73 μm) were observed in the topsoil of CT. More limited modifications were noticed in the soil structure of RT topsoil and subsoil layers but these latter are problematic in that the soil would no longer be loosened by subsequent tillage. These modifications could lead to soil consolidation as a result of wheel traffic year after year. [less ▲]

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See detailGemtuzumab Ozogamicin Versus Best Supportive Care in Older Patients With Newly Diagnosed Acute Myeloid Leukemia Unsuitable for Intensive Chemotherapy: Results of the Randomized Phase III EORTC-GIMEMA AML-19 Trial
Amadori, Sergio; Suciu, Stefan; Selleslag, Dominik et al

in Journal of Clinical Oncology (2016)

Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for ... [more ▼]

Purpose To compare single-agent gemtuzumab ozogamicin (GO) with best supportive care (BSC) including hydroxyurea as first-line therapy in older patients with acute myeloid leukemia unsuitable for intensive chemotherapy. Patients and Methods In this trial, patients at least 61 years old were centrally randomized (1:1) to receive either a single induction course of GO (6 mg/m2 on day 1 and 3 mg/m2 on day 8) or BSC. Patients who did not progress after GO induction could receive up to eight monthly infusions of the immunoconjugate at 2 mg/m2. Randomization was stratified by age, WHO performance score, CD33 expression status, and center. The primary end point was overall survival (OS) by intention-to-treat analysis. Results A total of 237 patients were randomly assigned (118 to GO and 119 to BSC). The median OS was 4.9 months (95% CI, 4.2 to 6.8 months) in the GO group and 3.6 months (95% CI, 2.6 to 4.2 months) in the BSC group (hazard ratio, 0.69; 95% CI, 0.53 to 0.90; P = .005); the 1-year OS rate was 24.3% with GO and 9.7% with BSC. The OS benefit with GO was consistent across most subgroups, and was especially apparent in patients with high CD33 expression status, in those with favorable/intermediate cytogenetic risk profile, and in women. Overall, complete remission (CR [complete remission] + CRi [CR with incomplete recovery of peripheral blood counts]) occurred in 30 of 111 (27%) GO recipients. The rates of serious adverse events (AEs) were similar in the two groups, and no excess mortality from AEs was observed with GO. Conclusion First-line monotherapy with low-dose GO, as compared with BSC, significantly improved OS in older patients with acute myeloid leukemia who were ineligible for intensive chemotherapy. No unexpected AEs were identified and toxicity was manageable. [less ▲]

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See detailCompte-rendu de Andrea Nicolotti, Le Saint Suaire de Besançon et le chevalier Othon de la Roche
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailHigh resolution characterization of the soil organic carbon depth profile in a soil landscape affected by erosion
Jague, Emilien; Sommer, Michael; Saby, Nicolas et al

in Soil & Tillage Research (2016), 156

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See detailReassessment of the acrylamide risk: Belgium as a case-study
Claes, Wendie; De Meulenaer, Bruno; Huyghebaert, André et al

in Food Control (2016), 59

Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various ... [more ▼]

Acrylamide is a food process contaminant with carcinogenic and genotoxic properties. As a result of intensive research, numerous mitigation initiatives to prevent its formation were suggested and various of them were implemented in the food chain. To evaluate if the mitigation strategies applied were significant, a comparison was made between two time periods (2002e2007 versus 2008e2013) in terms of acrylamide food levels and dietary exposure in Belgian. The most important changes observed are a significant decrease of the acrylamide content in potato crisps and gingerbread, and a significant increase in (instant) coffee. Additionally, the acrylamide content of breakfast cereals, bread and rolls, chocolate and baby biscuits showed a downward trend, whereas for coffee substitute and ready-to-eat French fries (mainly obtained from catering facilities), an upward, although not significant, trend was observed. These changes resulted in only a slight, but insignificant decline of the overall dietary exposure of adults, adolescents and children. The mean and P95 intake estimated in the 2008e2013 period for these consumer groups corresponded to margins of exposure (MOE) ranging between 515 and 236 and between 155 and 71, respectively, when based on the endpoint for neoplastic effects (BMDL10 ¼ 0.17 mg/kg bw per day). Such low MOE values indicate that acrylamide remains an issue for public concern, requiring renewed attention. [less ▲]

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See detailInvestigation on possible transmission of monkeys' Plasmodium to human in a populations living in the equatorial rainforest of the Democratic republic of Congo
MVUMBI, Dieudonné; BOBANGA, Thierry; UMESUMBU, Solange et al

in International Journal for Parasitology: parasites and wild life (2016), 5

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ... [more ▼]

Plasmodiums are protozoa that may infect various hosts. Only five species are now recognized as naturally parasitizing humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi. This fifth species, P. knowlesi, previously identified as naturally parasitizing the monkey Macaca fascicularis, has been microscopically confused for a long time with P. malariae or P. falciparum and it was not possible to correctly differentiate them until the advent of molecular biology. To date, natural human infections with P. knowlesi only occur in Southeast Asia and a similar phenomenon of natural transmission of simian plasmodium to humans has not been reported elsewhere. This study was conducted to investigate a possible transmission of African small monkey's plasmodium to humans in populations living near the rainforest of the Democratic Republic of Congo (DRC) where several species of non-human primates are living. Two successive real-time PCRs were identified in the literature and used in combination for purpose. Only P. falciparum was found in this study. However, studies with larger samples and with more advanced techniques should be conducted. [less ▲]

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See detailModeling heat stress under different environmental conditions
Carabano, Maria-Jesus; Logar, Betka; Bormann, Jeanne et al

in Journal of Dairy Science (2016)

Renewed interest in heat stress effects on livestock productivity derives from climate change, which is expected to increase temperatures and the frequency of extreme weather events. This study aimed at ... [more ▼]

Renewed interest in heat stress effects on livestock productivity derives from climate change, which is expected to increase temperatures and the frequency of extreme weather events. This study aimed at evaluating the effect of temperature and humidity on milk production in highly selected dairy cattle populations across three European regions differing in climate and production systems to detect differences and similarities that can be used to optimize heat stress (HS) effect modeling. Milk, fat and protein test day data from official milk recording for years 1999 to 2010 in four Holstein populations located in the Walloon Region of Belgium (BEL), Luxembourg (LUX), Slovenia (SLO) and Southern Spain (SPA) were merged with temperature and humidity data provided by the state meteorological agencies. After merging, the number of test day records/cows per trait ranged from 686,726/49,655 in SLO to 1,982,047/136,746 in BEL. Values for the daily average and maximum temperature and humidity index (THIavg and THImax) ranges for THIavg/THImax were largest in SLO (22-74/28-84) in SLO and shortest in SPA (39-76/46-83). Change point techniques were used to determine comfort thresholds, which differed across traits and climatic regions. Milk yield showed an inverted U shaped pattern of response across the THI scale with a HS threshold around 73 THImax units. For fat and protein, thresholds were lower than for milk yield and were shifted around 6 THI units towards larger values in SPA compared with the other countries. Fat showed lower HS thresholds than protein traits in all countries. The traditional broken line model was compared to quadratic and cubic fits of the pattern of response in production to increasing heat loads. A cubic polynomial model allowing for individual variation in patterns of response and THIavg as heat load measure showed the best statistical features. Higher/lower producing animals showed less/more persistent production (quantity and quality) across the THI scale. The estimated correlations between comfort and THIavg values of 70 (which represents the upper end of the THIavg scale in BEL-LUX) were lower for BEL-LUX (0.70 - 0.80) than for SPA (0.83 - 0.85). Overall, animals producing in the more temperate climates and semi-extensive grazing systems of BEL and LUX showed HS at lower heat loads and more re-ranking across the THI scale than animals producing in the warmer climate and intensive indoor system of SPA. [less ▲]

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See detailMigration, prostitution and the representation of the black female subject in Nigerian video films about Italy
Jedlowski, Alessandro ULg

in Journal of Italian Cinema and Media Studies (2016), 4(1), 9-23

Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the ... [more ▼]

Much contemporary images of black women in Italian media are marked by the legacy of colonialist propaganda and tend to perpetuate a representation of black women as passive eroticized objects of the white male gaze. In this sense, Ponzanesi’s call for ‘new and less biased representations, which could help to assess the multiple subject positions that black identities now occupy’ (2005: 179) is still relevant. This article responds to this call by analyzing two Nigerian video films that thematize migration and prostitution trafficking in Italy. By highlighting the complexity of the processes of ‘subjectivation’ taking place throughout the migratory process, these videos invite their viewers to look at the postcolonial subject’s responsibility in shaping the world in which s/he lives, and offer a representation of the black female subject able to go beyond the voyeuristic attitude that characterize much of the existing contemporary Italian visual culture about this topic. [less ▲]

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See detailCompte-rendu de L'atelier du médéiviste n°14 Les images dans l'Occident médiéval
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailRole of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb
Naser, Rayan; Vandenbosch, Renaud ULg; Omais, Saad et al

in Scientific Reports (2016)

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See detailA Belgian Survey on Geriatric Assessment in Oncology Focusing on Large-Scale Implementation and Related Barriers and Facilitators.
Kenis, C.; Heeren, P.; Decoster, L. et al

in The journal of nutrition, health & aging (2016), 20(1), 60-70

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for ... [more ▼]

OBJECTIVES: The aim of this study is to describe a large-scale, Belgian implementation project about geriatric assessment (=GA) in daily oncology practice and to identify barriers and facilitators for implementing GA in this setting. Design / setting / participants: The principal investigator of every participating hospital (n=22) was invited to complete a newly developed questionnaire with closed- and open-ended questions. The closed-ended questions surveyed how GA was implemented. The open-ended questions identified barriers and facilitators for the implementation of GA in daily oncology practice. Descriptive statistics and conventional content analysis were performed as appropriate. RESULTS: Qualifying criteria (e.g. disease status and cancer type) for GA varied substantially between hospitals. Thirteen hospitals (59.1%) succeeded to screen more than half of eligible patients. Most hospitals reported that GA data and follow-up data had been collected in almost all screened patients. Implementing geriatric recommendations and formulating new geriatric recommendations at the time of follow-up are important opportunities for improvement. The majority of identified barriers were organizational, with high workload, lack of time or financial/staffing problems as most cited. The most cited facilitators were all related to collaboration. CONCLUSION: Interventions to improve the implementation of GA in older patients with cancer need to address a wide range of factors, with organization and collaboration as key elements. All stakeholders, seeking to improve the implementation of GA in older patients with cancer, should consider and address the identified barriers and facilitators. [less ▲]

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See detailVolcanic eruptions boost tropical Pacific biological productivity
Chikamoto, Megumi O.; Timmermann, Axel; Yoshimori, Masakazu et al

in Geophysical Research Letters (2016)

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See detailDecitabine improves progression-free survival in older high-risk MDS patients with multiple autosomal monosomies: results of a subgroup analysis of the randomized phase III study 06011 of the EORTC Leukemia Cooperative Group and German MDS Study Group
Lübbert, Michael; Suciu, Stefan; Hagemeijer, Anne et al

in Annals of Hematology (2016), 95

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal ... [more ▼]

In a study of elderly AML patients treated with the hypomethylating agent decitabine (DAC), we noted a surprisingly favorable outcome in the (usually very unfavorable) subgroup with two or more autosomal monosomies (MK2+) within a complex karyotype (Lübbert et al., Haematologica 97:393-401, 2012). We now analyzed 206 myelodysplastic syndrome (MDS) patients (88 % of 233 patients randomized in the EORTC/GMDSSG phase III trial 06011, 61 of them with RAEBt, i.e. AML by WHO) with cytogenetics informative for MK status.. Endpoints are the following: complete/partial (CR/PR) and overall response rate (ORR) and progression-free (PFS) and overall survival (OS). Cytogenetic subgroups are the following: 63 cytogenetically normal (CN) patients, 143 with cytogenetic abnormalities, 73 of them MKnegative (MK−), and 70 MK-positive (MK+). These MK+ patients could be divided into 17 with a single autosomal monosomy (MK1) and 53 with at least two monosomies (MK2+). ORR with DAC in CN patients: 36.1 %, in MK−patients: 16.7 %, in MK+ patients: 43.6 % (MK1: 44.4 %, MK2+ 43.3 %). PFS was prolonged by DAC compared to best supportive care (BSC) in the CN (hazard ratio (HR) 0.55, 99 % confidence interval (CI), 0.26; 1.15, p=0.03) and MK2+ (HR 0.50; 99%CI, 0.23; 1.06, p=0.016) but not in the MK−, MK+, and MK1 subgroups. OS was not improved by DAC in any subgroup. In conclusion, we demonstrate for the first time in a randomized phase III trial that high-risk MDS patients with complex karyotypes harboring two or more autosomal monosomies attain encouraging responses and have improved PFS with DAC treatment compared to BSC. [less ▲]

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See detailSartre in Venedig: der Mann, der in die Kälte ging
Cormann, Grégory ULg; Viehöver, Vera ULg

in Bulletin d'Analyse Phénoménologique (2016), 11

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See detailSubstituted azafluorenones: access from dihalogeno diaryl ketones by palladium-catalyzed auto-tandem processes and evaluation of their antibacterial, antifungal, antimalarial and antiproliferative activities
Marquise, Nada; Chevallier, Floris; Nassar, Ekhlas et al

in Tetrahedron (2016)

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions ... [more ▼]

Substituted azafluorenones were synthesized from dihalogeno diaryl ketones under palladium catalysis by combining, in auto-tandem processes, Suzuki coupling and intramolecular arylation reactions. Different dihalogenated diaryl ketones, prepared by sequential deprotocupration-aroylation, were identified as suitable substrates to this purpose. Conditions were identified to allow successful syntheses of several 6-/7-arylated 4-azafluorenones, 1-substituted 4-azafluorenones, 2-phenyl-3-azafluorenone, and 4-phenyl-3-azafluorenone from 3-(bromobenzoyl)-2-chloropyridines, 3-benzoyl-4-bromo-2-chloropyridines, 4-benzoyl-2,5-dichloropyridine, and 4-benzoyl-2,3-dichloropyridine, respectively. Some of the synthesized compounds exhibit interesting biological properties [less ▲]

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See detailFire Fragility Curves for Steel Buildings in a Community Context: A Methodology
Gernay, Thomas ULg; Elhami Khorasani, Negar; Garlock, Maria

in Engineering Structures (2016)

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to ... [more ▼]

This paper proposes a novel methodology for developing fire fragility functions for an entire steel building - meaning that the function is not specific to a location within the building. The aim is to characterize the probabilistic vulnerability of steel buildings to fire in the context of community resilience assessment. In developing the fragility functions, uncertainties in the fire model, the heat transfer model and the thermo-mechanical response are considered. In addition several fire scenarios at different locations in the building are studied. Monte Carlo Simulations and Latin Hypercube Sampling are used to generate the probability distributions of demand placed on the members and structural capacity relative to selected damage thresholds. By assessing demand and capacity in the temperature domain, the thermal and the structural problems can be treated separately to improve the efficiency of the probabilistic analysis. After the probability distributions are obtained for demand and capacity, the fragility functions can be obtained by convolution of the distributions. Finally, event tree analysis is used to combine the functions associated with fire scenarios in different building locations. The developed fire fragility functions yield the probability of exceedance of predefined damage states as a function of the fire load in the building. The methodology is illustrated on an example consisting in a prototype nine-story steel building based on the SAC project. [less ▲]

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See detailL’enfant, l’institutrice et le tableau interactif : Corps relationnel et évolution numérique
Jadin, Aurore ULg; Englebert, Jérôme ULg

in Cahiers de Psychologie Clinique (2016), 46

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical ... [more ▼]

In clinical psychology, the ecological observation of child in different life domains offers many inaccessible observations through the individual therapy sessions. The article proposes, from a clinical case, a reflection on the technological change of classes, particularly through the use of the interactive whiteboard, and the psychological and relational consequences of this revolution, for each of the protagonists. A consequence of this use of the digital device is that the body can appear less necessary and therefore be abandoned in favor of a poorly invested technicality. Our analysis values the development of a necessary compromise between digital and body. It proposes to find ways of arranging so that teacher's body is still a fundamental dimension of the educational process. [less ▲]

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See detailPalindromic sequences generated from marked morphisms
Labbé, Sébastien ULg; Pelantova, Edita

in European Journal of Combinatorics (2016), 51

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See detailPhysico-chemical properties and amino acid profiles of sap from Tunisian date palm
Makhouf-Gafsi, Ines; Mokni-Ghribi, Abir; Brahim, Bchir et al

in Scientia Agricola (2016), 73(1), 85-90

Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of ... [more ▼]

Date palm sap (Phoenix dactylifera L.), also known as "legmi", is a fresh juice ex¬tracted from date palm trees. The present study aimed to elucidate the effects of collection time (at the beginning of the tapping period and after seven days of collection) on the amino acid profile and physico-chemical properties of date palm sap from both male and female trees. Dry matter, protein, amino acid, and sugar profiles were determined using the Kjeldahl method, High-Performance Liquid Chromatography (HPLC), and High-Performance Anion-Exchange Chro¬matography with Pulsed Amperometric Detection (HPAEC-PAD), respectively. Date palm sap from both male and female trees contained high levels of carbohydrates. HPLC analysis showed that this fraction was dominated by sucrose in the sap sample from female trees compared to that from male trees. Male date palm sap was noted to exhibit lower dry matter content than female date palm sap but higher protein, total polyphenol, ash, and amino acid contents. While the major essential amino acids in the sap from male trees consisted of valine and threonine, they were represented by lysine and phenylalanine in sap samples from female trees. Further, Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) analysis showed the presence of a proteinic band of 30 kDa only for the sap from male trees. Taken together, the sap from both male and female date palm trees had a number of properties that are highly valued by the functional food industry. [less ▲]

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See detailCorrelation between resting state fMRI total neuronal activity and PET metabolism in healthy controls and patients with disorders of consciousness
Soddu, Andrea ULg; Gomez, Francisco; Heine, Lizette ULg et al

in Brain and Behavior (2016)

Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made ... [more ▼]

Introduction: The mildly invasive 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established imaging technique to measure ‘resting state’ cerebral metabolism. This technique made it possible to assess changes in metabolic activity in clinical applications, such as the study of severe brain injury and disorders of consciousness. Objective: We assessed the possi- bility of creating functional MRI activity maps, which could estimate the rela- tive levels of activity in FDG-PET cerebral metabolic maps. If no metabolic absolute measures can be extracted, our approach may still be of clinical use in centers without access to FDG-PET. It also overcomes the problem of recogniz- ing individual networks of independent component selection in functional mag- netic resonance imaging (fMRI) resting state analysis. Methods: We extracted resting state fMRI functional connectivity maps using independent component analysis and combined only components of neuronal origin. To assess neu- ronality of components a classification based on support vector machine (SVM) was used. We compared the generated maps with the FDG-PET maps in 16 healthy controls, 11 vegetative state/unresponsive wakefulness syndrome patients and four locked-in patients. Results: The results show a significant similarity with q = 0.75  0.05 for healthy controls and q = 0.58  0.09 for vegetative state/unresponsive wakefulness syndrome patients between the FDG- PET and the fMRI based maps. FDG-PET, fMRI neuronal maps, and the conjunction analysis show decreases in frontoparietal and medial regions in vegetative patients with respect to controls. Subsequent analysis in locked-in syndrome patients produced also consistent maps with healthy controls. Conclusions: The constructed resting state fMRI functional connectivity map points toward the possibility for fMRI resting state to estimate relative levels of activity in a metabolic map. [less ▲]

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See detailL’impact des activités non agricoles sur la pauvreté et l’inégalité rurales dans les groupements Bugorhe et Irhambi-Katana (Territoire de Kabare, Province du Sud-Kivu)
Furaha Mirindi, Germaine ULg; Namegabe Mastaki, Jean Luc; Lebailly, Philippe ULg

in JOURNAL OF ORIENTAL AND AFRICAN STUDIES (2016), 25

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of ... [more ▼]

Using a survey on the socio-economic situation of households in 2012, the study analyses the effect of non farm income on inequality and poverty alleviation in a rural area of the Democratic Republic of Congo, by comparing a group of households practicing agriculture only and another group which combines agriculture and nonfarm activities. The approach used considers non farm income as an exogenous transfer which completes the whole household income, and analyses the contribution of different sources of income on the inequality in using the Gini index. The results show that inequality increases when a segment of the population does not have access to non-agricultural income. In this case, non farm income is not a substitute of farm income, rather the complement. The poverty analysis is based on the Congolese rural threshold poverty in terms of basic needs to calculate the rate, depth and severity of poverty indexes in using of Foster- Greer-Thorbecke. The results show that households practicing agriculture only are poorer. [less ▲]

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See detail2015 ESC Guidelines for the management of infective endocarditis.
Habib, Gilbert; LANCELLOTTI, Patrizio ULg; Antunes, Manuel J. et al

in Revista espanola de cardiologia (English ed.) (2016), 69(1), 69

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See detailDetermination of total phenolic compounds content and antioxidant activity in cherry species and cultivars
Pissard, Audrey; Lateur, Marc; Baeten, V et al

in Journal of Berry Research (2016)

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound ... [more ▼]

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound (TPC) content and the antioxidant capacity (AC) of a large range of cultivars using the same methodology in one laboratory, and (ii) determine the possible relationship between agronomic characteristics and AC. METHODS: A total of 245 samples including sweet, sour and hybrid cultivars from our collections were harvested at their optimum maturity and characterized according to their TPC, DPPH and ORAC values. RESULTS: The TPC content and DPPH and ORAC values varied greatly among the cherries, with the sour cultivars presenting higher levels than the sweet ones. The PCA plot showed a slight grouping by species and confirmed the high TPC content level in sour cultivars. The bi-colored cultivars had lower TPC and antioxidant capacity (AC) values than dark-colored ones, indicating that coloration could give an indication of the AC of fruits. No significant relationship between the agronomic and chemical properties was highlighted. CONCLUSIONS: Cherry fruits, especially from sour cultivars, represent an important source of bioactive compounds and could attract new interest as a ‘functional food’. [less ▲]

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See detailLarge predatory marine reptiles from the Albian–Cenomanian of Annopol, Poland
Bardet, Nathalie; Fischer, Valentin ULg; Machalski, Marcin

in Geological Magazine (2016)

During the Early–Late Cretaceous transition, marine ecosystems in Eurasia hosted a diverse set of large predatory reptiles that occupied various niches. However, most of our current knowledge of these ... [more ▼]

During the Early–Late Cretaceous transition, marine ecosystems in Eurasia hosted a diverse set of large predatory reptiles that occupied various niches. However, most of our current knowledge of these animals is restricted to a small number of bonebed-like deposits. Little is known of the geographical and temporal extent of such associations. The middle Albian – middle Cenomanian phosphorite-bearing succession exposed at Annopol, Poland produces numerous ichthyosaurian and plesiosaurian fossils. These are mostly isolated skeletal elements (e.g. teeth, vertebrae), but disarticulated partial skeletons and an articulated, sub vertically embedded ichthyosaur skull are also available. The following taxa are identified: ‘Platypterygius’ sp., cf. Ophthalmosaurinae, Ichthyosauria indet., Polyptychodon interruptus, Pliosauridae indet., Elasmosauridae<indet. and Plesiosauria indet. The large-sized ichthyosaur ‘Platypterygius’ and the pliosaurid Polyptychodon interruptus predominate within the upper Albian – middle Cenomanian deposits. The Annopol record, combined with data from England, France and western Russia, suggests that ‘Platypterygius’ and Polyptychodon interruptus formed a long-term, stable ecological sympatry in marine ecosystems of the European archipelago, at least during the Albian – middle Cenomanian. In addition, the marine reptile assemblage from Annopol is distinct from other Eurasian ecosystems in containing also elasmosaurids in its Albian portion. [less ▲]

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See detailCore Outcome Measure Index for low back patients: do we miss anxiety and depression?
Cedraschi, C; Marty, M; Courvoisier, DS et al

in European Spine Journal (2016), 25

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See detailAccelerating chemoselective peptide bond formation using bis(2-selenylethyl)amido peptide selenoester surrogates
Raibaut, Laurent; Cargoët, Marine; Ollivier, Nathalie et al

in Chemical Science (2016)

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis ... [more ▼]

Given the potential of peptide selenoesters for protein total synthesis and the paucity of methods for the synthesis of these sensitive peptide derivatives, we sought to explore the usefulness of the bis(2-selenylethyl)amido (SeEA) group, i.e. the selenium analog of the bis(2-sulfanylethyl)amido (SEA) group, for accelerating peptide bond formation. A chemoselective exchange process operating in water was devised for converting SEA peptides into the SeEA ones. Kinetic studies show that SeEA ligation, which relies on an initial N,Se-acyl shift process, proceeds significantly faster than SEA ligation. This property enabled the design of a kinetically controlled three peptide segment assembly process based on the sequential use of SeEA and SEA ligation reactions. The method was validated by the total synthesis of hepatocyte growth factor K1 (85 AA) and biotinylated NK1 (180 AA) domains [less ▲]

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See detailDetermination of total phenolic compounds content and antioxidant activity in cherry species and cultivars
Pissard, Audrey; Lateur, Marc; Baeten, V et al

in Journal of Berry Research (2016)

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound ... [more ▼]

BACKGROUND: Several studies have shown that cherries, especially sour cultivars, contain substantial amounts of phenolic compounds. OBJECTIVE: This study aims to (i) analyze the total phenolic compound (TPC) content and the antioxidant capacity (AC) of a large range of cultivars using the same methodology in one laboratory, and (ii) determine the possible relationship between agronomic characteristics and AC. METHODS: A total of 245 samples including sweet, sour and hybrid cultivars from our collections were harvested at their optimum maturity and characterized according to their TPC, DPPH and ORAC values. RESULTS: The TPC content and DPPH and ORAC values varied greatly among the cherries, with the sour cultivars presenting higher levels than the sweet ones. The PCA plot showed a slight grouping by species and confirmed the high TPC content level in sour cultivars. The bi-colored cultivars had lower TPC and antioxidant capacity (AC) values than dark-colored ones, indicating that coloration could give an indication of the AC of fruits. No significant relationship between the agronomic and chemical properties was highlighted. CONCLUSIONS: Cherry fruits, especially from sour cultivars, represent an important source of bioactive compounds and could attract new interest as a ‘functional food’. [less ▲]

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See detailAbelian bordered factors and periodicity
Charlier, Emilie ULg; Harju, Tero; Puzynina, Svetlana et al

in European Journal of Combinatorics (2016), 51

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only ... [more ▼]

A finite word u is said to be bordered if u has a proper prefix which is also a suffix of u, and unbordered otherwise. Ehrenfeucht and Silberger proved that an infinite word is purely periodic if and only if it contains only finitely many unbordered factors. We are interested in abelian and weak abelian analogues of this result; namely, we investigate the following question(s): Let w be an infinite word such that all sufficiently long factors are (weakly) abelian bordered; is w (weakly) abelian periodic? In the process we answer a question of Avgustinovich et al. concerning the abelian critical factorization theorem. [less ▲]

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See detailSolidarity economy and its anarchist grammar
Frère, Bruno ULg

in Sociology and anthropology (2016), 5(24),

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local ... [more ▼]

‘Solidarity economy’, a widely used term for which the most common French equivalent is economie solidaire, is generally thought of as comprising five distinct classes of activity : Micro-finance, Local Exange Trading Systems, proximity services, organic community supported agriculture and fairtrade distributions. Because they try to answer to the Aristotelian theoretical question “what can we do to live harmoniously together?”, these solidarity initiatives are deeply political in the philosophical sense of the term. They galvanize civic commitment at the “micro” level. But today, an important question arises regarding the kind of formal political institution that would speak in the name of all these initiatives. In France, some intellectuals who have an interest in these solidarity initiatives see them as new economic models with the potential to solve the current financial crisis, and they are eager for academic specialists and leaders of the movement to achieve some kind of consensus about the kind of concrete political identity such initiatives may be expected to generate. However this paper studies their way of establishing a basis for moving from micro level initiatives to substantial “macro” polity unity. Using the insights of french pragmatic sociology, and particularly the notion of grammar of justification, it aims to understand what the obstacles to this aim being realised are. [less ▲]

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See detailWhat drives the development of community energy in Europe? The case of wind power cooperatives
Bauwens, Thomas ULg; Gotchev, Boris; Holstenkamp, Lars

in Energy Research & Social Science (2016), 13

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being ... [more ▼]

The dominant model of energy infrastructure has historically been conceived in a very centralized fashion, i.e. with hardly any citizen involvement in energy generation. Yet, increasing attention is being paid to the transition process towards a more decentralized configuration. This article examines the factors likely to foster citizen and community participation as regards wind power cooperatives in Denmark, Germany, Belgium and the UK. Using Elinor Ostrom’s Social-Ecological System Framework, the analysis highlights a double-edged phenomenon: prevailing and growing hostility towards cooperatives, on the one hand, and, on the other, strategic reactions to this evolution. What comes out indeed is that, throughout most of these countries, the emergence of some coordinated inter-organizational actions among cooperatives enables them to survive in their critical environment. [less ▲]

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See detailRecurrent pulsations in Saturn’s high latitude magnetosphere
Mitchell, D.G.; Carbary, J.F.; Bunce, E.J. et al

in Icarus (2016)

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See detailA Mixed Integer Programming formulation for the three dimensional bin packing problem deriving from an air cargo application
Paquay, Célia ULg; Schyns, Michael ULg; Limbourg, Sabine ULg

in International Transactions in Operational Research (2016), 23(1-2), 187-213

The present paper looks into the problem of optimising the loading of boxes into containers. The goal is to minimise the unused volume. This type of problem belongs to the family of Multiple Bin Size Bin ... [more ▼]

The present paper looks into the problem of optimising the loading of boxes into containers. The goal is to minimise the unused volume. This type of problem belongs to the family of Multiple Bin Size Bin Packing Problems. The approach includes an extensive set of constraints encountered in real-world applications in the three-dimensional case: the stability, the fragility of the items, the weight distribution and the possibility to rotate the boxes. It also includes the specific situation in which containers are truncated parallelepipeds. This is typical in the field of air transportation. While most papers on cutting and packing problems describe ad-hoc procedures, this paper proposes a mixed integer linear program. The validity of this model is tested on small instances. [less ▲]

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See detailImprovement of malignant pleural mesothelioma immunotherapy by epigenetic modulators
Hamaïdia, Malik ULg; Staumont, Bernard ULg; DUYSINX, Bernard ULg et al

in Current Topics in Medicinal Chemistry (2016), 16

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor ... [more ▼]

In the absence of a satisfactory treatment of malignant pleural mesothelioma (MPM), novel therapeutic strategies are urgently needed. Among these, immunotherapy offers a series of advantages such as tumor specificity and good tolerability. Unfortunately, MPM immunotherapy is frequently limited by incomplete cell differentiation or feedback loop regulatory mechanisms. In this review, we describe different components of the innate immune system and discuss strategies to improve MPM immunotherapy by using epigenetic modulators. [less ▲]

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See detailSaturn’s auroral morphology and field-aligned currents during a solar wind compression
Badman, S.V.; Provan, G.; Bunce, E.J. et al

in Icarus (2016)

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See detailcompte rendu de : Lenglet-Dufresnoy, Écrits inédits sur le roman. Édité par J. Herman et J. Cormier. Oxford, Voltaire Foundation, 2014.
Decoster, Sara ULg

in Revue d'Histoire Littéraire de la France (2016), 116(1), 222-224

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See detailQuasi-periodic injections of relativistic electrons in Saturn's outer magnetosphere
Roussos, E.; Krupp, N.; Mitchell, D. G. et al

in Icarus (2016), 263

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See detailGPR101 mutations are not a frequent cause of congenital isolated growth hormone deficiency
Castinetti, F; Daly, Adrian ULg; Stratakis, CA et al

in Hormone & Metabolic Research (2016)

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See detailFlexible estimation in cure survival models using Bayesian P-splines
Bremhorst, Vincent; Lambert, Philippe ULg

in Computational Statistics & Data Analysis (2016), 93

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an ... [more ▼]

In the analysis of survival data, it is usually assumed that any unit will experience the event of interest if it is observed for a sufficiently long time. However, it can be explicitly assumed that an unknown proportion of the population under study will never experience the monitored event. The promotion time model, which has a biological motivation, is one of the survival models taking this feature into account. The promotion time model assumes that the failure time of each subject is generated by the minimum of N independent latent event times with a common distribution independent of N. An extension which allows the covariates to influence simultane- ously the probability of being cured and the latent distribution is presented. The latent distribution is estimated using a flexible Cox proportional hazard model where the logarithm of the baseline hazard function is specified using Bayesian P-splines. Introducing covariates in the latent distribution implies that the population hazard function might not have a proportional hazard structure. However, the use of P- splines provides a smooth estimation of the population hazard ratio over time. The identification issues of the model are discussed and a restricted use of the model when the follow up of the study is not sufficiently long is proposed. The accuracy of our methodology is evaluated through a simulation study and the model is illustrated on data from a Melanoma clinical trial. [less ▲]

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See detailFarmers’ Perception and Willingness to Pay for Climate Information in Burkina Faso
Zongo, Bétéo ULg; Diarra, Abdoulaye; Barbier, Bruno et al

in Journal of Agricultural Science (2016), 8

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access ... [more ▼]

This study highlights the perception and the option value of climate information in the sahelian and sudano-sahelian agro-climatic zones of Burkina Faso. From the sampled farmers only 21.78% have access to climate information, while 93% of them need climate information to guide through their decision in planning agricultural activities. Option value shows the interest granted by farmers using climate information. About 64% of the farmers are willing to pay an average of Francs CFA 546.34 to obtain climate information. The willingness to pay is determined by the the farmers’ ability to predict the climate, to use radio as a means of information, farmers’ awareness of previous forecasts and early onset of rainy season. While farmers considered benefits from the use of climate information, it is clear that its contribution to farm income remains a field of research to explore. Thus it is necessary to experiment with individual farms and to evaluate the contribution of climate information to the value added in different crops and farmers’ income. [less ▲]

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See detailLes catégories au seuil de la phénoménologie
Gauvry, Charlotte ULg; Fagniez, Guillaume

in Etudes Philosophiques (Les) (2016)

Le tournant du XXe siècle est marqué par un retour de la problématique catégoriale sur le devant de la scène philosophique, que ce soit chez Franz Brentano et ses élèves, chez Wilhelm Dilthey, chez les ... [more ▼]

Le tournant du XXe siècle est marqué par un retour de la problématique catégoriale sur le devant de la scène philosophique, que ce soit chez Franz Brentano et ses élèves, chez Wilhelm Dilthey, chez les Néokantiens de l’école de Bade, ou chez les premiers pionniers de la phénoménologie. Tant et si bien qu’une certaine philosophie (celle d’Emil Lask par excellence) a pu se présenter comme une doctrine des catégories à part entière. L’enjeu de ce numéro est d’interroger la place historique et le rôle conceptuel qu’ont joué ces questions formelles dans l’émergence de la phénoménologie. Kant avait certes renoué avec la question aristotélicienne des catégories pour postuler l’existence de « purs concepts de l’entendement » ou « catégories », seuls susceptibles de « fournir de l’unité aux diverses représentations dans un jugement et [de] donner aussi à la simple synthèse de diverses représentations dans une intuition une unité » (KRV, §10). L’intérêt proto-phénoménologique pour les catégories se présente-t-il cependant comme un retour, par-delà l’idéalisme allemand, à cette problématique transcendantale kantienne ou bien plutôt comme un retour, par-delà Kant lui-même, à la question aristotélicienne ? Si les philosophes du début XXe se sont ressaisis de la question des catégories, il semble qu’ils aient à tout le moins reformulé, voire abandonné la méthode de la « déduction ». C’est ce travail de reformulation de la déduction transcendantale que le numéro entend également clarifier. Peut-on encore dire que ces catégories sont « déduites » des formes logiques du jugement, des objets logiques ou du mouvement même de la vie ? S’il y a lieu de mettre au jour un processus « génétique » de la catégorie, quelles sont les implications d’un tel déplacement relativement à la validité du catégorial ? Plus généralement, c’est le statut même de ces « catégories » qui sera analysé. Leur domaine d’application redéfini, peut-on les déterminer comme des concepts purs transcendantaux susceptibles d’unifier l’expérience sensible ? Les catégories ne doivent-elles pas plutôt être repensées comme des formes logiques, sémantiques ou même ontologiques ? Ainsi, c’est l’enjeu stratégique de la résurgence de cette problématique catégoriale, et ses répercussions directes sur l’émergence de la phénoménologie naissante (husserlienne et heideggérienne) que ce numéro interrogera. [less ▲]

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See detailThe transactional process between the relationships with caregivers and children's externalizing behavior
Roskam, Isabelle; Stievenart, Marie ULg; de Mol, Jan

in Journal of Applied Developmental Psychology (2016), 42

Externalizing behavior (EB) has been found to be pervasive in children across different interactional systems. The transactional model is one of the most interesting and plausible mechanisms explaining ... [more ▼]

Externalizing behavior (EB) has been found to be pervasive in children across different interactional systems. The transactional model is one of the most interesting and plausible mechanisms explaining the development of behavioral problems (Sameroff, 2009). The main goal of the study is to test bidirectional and recursive transactional relations between the quality of the caregiver–child relationship and children's externalizing behavior. The transactional model was tested in three-wave longitudinal cross-lagged models involving 117 children (78.5% boys) aged 4 at the beginning of the study and three caregivers, i.e. their mother, father and teacher. All of the children had been clinically referred for externalizing behavior. Themulti-informant three-wave design was an original feature of this research. The results provided no evidence for a transactional process. The results suggest the singularity of each ofthese three interactional systems. They are discussed from the theoretical viewpoint and in terms of their clinical implications. [less ▲]

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See detailSPICAM observations and modeling of Mars aurorae
Soret, Lauriane ULg; Gérard, Jean-Claude ULg; Libert, Ludivine ULg et al

in Icarus (2016), 264

Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the ... [more ▼]

Martian aurorae have been detected with the SPICAM instrument on board Mars Express both in the nadir and the limb viewing modes. In this study, we focus on three limb observations to determine both the altitudes and the intensities of the auroral emissions. The CO (a3P–X1R) Cameron bands between 190 and 270 nm, the CO Fourth Positive system (CO 4P) between 135 and 170 nm, the CO2+ doublet at 289 nm, the OI at 297.2 nm and the 130.4 nm OI triplet emissions have been identified in the spectra and in the time variations of the signals. The intensities of these auroral emissions have been quantified and the altitude of the strongest emission of the CO Cameron bands has been estimated to be 137 ± 27 km. The locations of these auroral events have also been determined and correspond to the statistical boundary of open-closed magnetic field lines, in cusp-like structures. The observed altitudes of the auroral emissions are reproduced by a Monte-Carlo model of electron transport in the Martian thermosphere for mono-energetic electrons between 40 and 200 eV. No correlation between electron fluxes measured in the upper thermosphere and nadir auroral intensity has been found. Here, we simulate auroral emissions observed both at the limb and at the nadir using electron energy spectra simultaneously measured with the ASPERA-3/ELS instrument. The simulated altitudes are in very good agreement with the observations. We find that predicted vertically integrated intensities for the various auroral emissions are overestimated, probably as a consequence of the inclination and curvature of the magnetic field line threading the aurora. However, the relative brightness of the CO and CO2+ emissions is in good agreement with the observations. [less ▲]

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See detailNew Insight on the Performance of Equity Long/short Investment Styles
Fays, Boris ULg; Hübner, Georges ULg; Lambert, Marie ULg

in Bankers, Markets, Investors (2016), 140(January-February), 34-45

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of ... [more ▼]

Long-short equity strategies have recently generated exceptional performance raising a set of concerns about the strategies’ propensity to deliver alpha or beta. This paper revisits the performance of equity long-short hedge funds across investments styles. We first categorize individual hedge funds with regard to their size and/or value factor investing along the generalization of Sharpe (1992) style analysis. Style weights on size and value factors are used to split the equity long-short universe in 5x5 hedge fund style portfolios. To analyze the performance of each style, we consider two sets of innovative factors. First, we apply sequential Fama-French model of Lambert, Fays and Hübner (2015). Besides, to captures downside and extreme risk embedded in hedge fund strategies we augment the model with the co-skewness and co-kurtosis factors developed by Lambert and Hübner (2013). Under this framework, we perform cross-sectional performance analyses of individual hedge funds as well as time-series analysis on the hedge fund style broad category. Our contributions are threefold; first, our alternative framework significantly improves the explanatory power of the multi-factor model in the context of long-short equity funds, second, considering higher-moment factors aim to capture part of the abnormal return of the downside and extreme risk exposures taken by a fund manager, and finally, long-short equity hedge funds are, to some extent, less exposed to small capitalisation stocks than expected and instead rather prefer higher momentum levels in their strategies. [less ▲]

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See detailThe Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao, Martine ULg; Royce, Darlene B.; Risingsong, Renee et al

in Cancer prevention research (Philadelphia, Pa.) (2016), 9(1), 105-14

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both ... [more ▼]

LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer in A/J mice. These molecules markedly reduced tumor number, tumor size, and total tumor burden, when chronically administered to A/J mice that had been initiated with the mutagenic carcinogen, vinyl carbamate. Moreover, LG100268 synergized with the histone deacetylase inhibitor, vorinostat, for prevention of experimental lung cancer and enhanced the effect of carboplatin/paclitaxel for treatment of experimental lung cancer. Both rexinoids diminished the percentage of high-grade, highly malignant adenocarcinomas found at autopsy. In cell culture studies, the rexinoids exhibited potent anti-inflammatory properties at nanoMolar concentrations. These drugs suppressed the ability of lipopolysaccharide to stimulate the synthesis and secretion of nitric oxide and inflammatory cytokines and chemokines, such as IL6, IL1beta, CXCL2, and CSF3, in macrophage-like RAW264.7 cells. The present results suggest that LG100268, LG101506, or a related rexinoid may have useful clinical applications in the field of oncology. Cancer Prev Res; 9(1); 105-14. (c)2015 AACR. [less ▲]

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See detailPersistent low levels of serum hCG due to heterophilic mouse antibodies: an unrecognized pitfall in the diagnosis of trophoblastic disease.
Gonzalez Aguilera, B.; Syrios, P.; Gadisseur, R et al

in Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2016)

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old ... [more ▼]

Phantom hCG refers to persistent mild elevations of hCG, leading physicians to unnecessary treatments whereas neither a true hCG nor a trophoblastic disease is present. We report the case of a 23-year-old woman with persistent low levels of serum hCG detected one month after miscarriage. As choriocarcinoma was suspected, a chemotherapy trial of methotrexate was prescribed, without any hCG reduction. Subsequently, laparoscopy ruled out a trophoblastic residue and the patient was referred to the Endocrine Unit for further investigations. While low levels of hCG were still detected in serum, no hCG was detected in the urine. In addition, when serum was processed in a HBT tube for revealing heterophilic antibodies, hCG was no longer detected. Such finding indicated the presence of phantom hCG due to heterophilic mouse antibodies interaction. This case raises the need of clinico-biological discussion to avoid inappropriate therapeutic decisions. Based on this case experience and after review of the literature, we suggest that current gynecological protocols for the diagnosis and treatment of trophoblastic disease should consider the inclusion of urinary hCG and/or a test for serum heterophilic antibodies when appropriate. [less ▲]

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See detailCombining feature extraction methods to assist the diagnosis of Alzheimer’s disease
Segovia, Fermin; Gorriz, J. M.; Ramirez, J. et al

in Current Alzheimer Research (2016)

Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the ... [more ▼]

Neuroimaging data as 18F-FDG PET is widely used to assist the diagnosis of Alzheimer’s disease (AD). Looking for regions with hypoperfusion/ hypometabolism, clinicians may predict or corroborate the diagnosis of the patients. Modern computer aided diagnosis (CAD) systems based on the statistical analysis of whole neuroimages are more accurate than classical systems based on quantifying the uptake of some predefined regions of interests (ROIs). In addition, these new systems allow determining new ROIs and take advantage of the huge amount of information comprised in neuroimaging data. A major branch of modern CAD systems for AD is based on multivariate techniques, which analyse a neuroimage as a whole, considering not only the voxel intensities but also the relations among them. In order to deal with the vast dimensionality of the data, a number of feature extraction methods have been successfully applied. In this work, we propose a CAD system based on the combination of several feature extraction techniques. First, some commonly used feature extraction methods based on the analysis of the variance (as principal component analysis), on the factorization of the data (as non-negative matrix factorization) and on classical magnitudes (as Haralick features) were simultaneously applied to the original data. These feature sets were then combined by means of two different combination approaches: i) using a single classifier and a multiple kernel learning approach and ii) using an ensemble of classifier and selecting the final decision by majority voting. The proposed approach was evaluated using a labelled neuroimaging database along with a cross validation scheme. As conclusion, the proposed CAD system performed better than approaches using only one feature extraction technique. We also provide a fair comparison (using the same database). - See more at: http://www.eurekaselect.com/136992/article#sthash.PPiyE35K.dpuf [less ▲]

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See detailManaging Chronic Kidney Disease in Older People--Reply
Glassock, rj; DELANAYE, Pierre ULg; El-Nahas, M

in JAMA : Journal of the American Medical Association (2016), 315(3),

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See detailCarbon xerogels as model materials: toward a relationship between pore texture and electrochemical behavior as anodes for lithium-ion batteries
Piedboeuf, Marie-Laure ULg; Léonard, Alexandre ULg; Deschamps, Fabien ULg et al

in Journal of Materials Science (2016)

The mechanisms of Li+ insertion in porous hard carbons used as anodes for Li-ion batteries are still a matter of debate, especially considering the divergence of electrochemical performances observed in ... [more ▼]

The mechanisms of Li+ insertion in porous hard carbons used as anodes for Li-ion batteries are still a matter of debate, especially considering the divergence of electrochemical performances observed in literature. Since these materials usually exhibit several levels of porosity, the pore texture vs. electrochemical behavior relationship is difficult to establish. In this paper, we propose to use carbon xerogels, prepared from aqueous resorcinol-formaldehyde mixtures, as model materials for Li-ion battery anodes to study the influence of the pore texture on the overall electrochemical behavior. Indeed, carbon xerogels are described as microporous nodules linked together to form meso- or macroporous voids inside a 3D gel structure; the size of these voids can be tuned by changing the synthesis conditions without affecting other parameters such as the micropore volume. The materials are chosen so as to obtain identical average particle sizes, homogeneous coatings with similar thicknesses and a comparable surface chemistry. The electrochemical behavior of carbon xerogels as Li-ion anodes are correlated with the surface accessible to the electrolyte and are not dependent on the total specific surface area calculated by the BET method from nitrogen adsorption isotherms. The key parameter proposed to understand their behavior is the external surface area of the nodules, which corresponds to the surface of the meso/macropores. [less ▲]

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See detailPhénoménologie et grammaire
Leclercq, Bruno ULg; Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2016)

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels ... [more ▼]

Dans le prolongement des travaux sur l’analyticité formelle de Bernard Bolzano, la phénoménologie naissante se caractérise par une attention à la structuration du sens selon des principes purement formels qui conditionnent la possibilité même de la signification. Husserl par excellence, dans la quatrième Recherche Logique, dégage l’idée d’une grammaire pure régissant les conditions du sens possible (par opposition au non-sens) avant même qu'intervienne la question logique de la consistance (par opposition au contresens). Ce niveau grammatical s’articule autour de catégories de la signification (matière nominale, matière adjectivale, ...) et des lois de leur combinaison, catégories et lois qui peuvent être dégagées par des tests de substituabilité « salva significatione ». Cette idée d’une structure purement grammaticale des significations est aussi explorée par d’autres disciples de Brentano comme Anton Marty, lequel prend part au débat sur la possibilité des « propositions sans sujets » dès ses articles de 1884-1896. Or cette approche formelle de la grammaire qui a réglé l’émergence de la phénoménologie ne va pas sans poser de questions. L’enjeu du numéro est d’interroger le type de formalisme qui est en jeu à l’origine de la phénoménologie pour en préciser les sens et en tester la longévité. La question se pose tout d’abord de savoir si l’hypothèse d’une légalité purement grammaticale est pertinente et quels rapports elle entretiendrait avec 1) la légalité spécifiquement linguistique liée à l'expression de ces significations dans telle ou telle langue ou même dans le langage en général. Les catégories de signification et les lois de leur combinaison précèdent-elles tout langage ? 2) la légalité ontologique qui est celle des objets pensés à travers ces significations. Les objets imposent-ils leur structure aux significations à travers lesquelles on les pense ou, au contraire, les significations imposent-elles leur structure aux objets pensés à travers elles ? 3) la légalité phénoménale qui régit plus particulièrement l'expérience sensible (synthèses passives, etc.). 4) Par ailleurs, on peut se demander si cette légalité grammaticale dégagée par Husserl est purement syntaxique (c’est-à-dire qu’elle se définirait essentiellement par opposition aux combinaisons de signification insensées parce que syntaxiquement mal formées comme « vert est ou ») ou si elle est également sémantique (c’est-à-dire qu’elle se définirait également par opposition aux combinaisons de signification insensées parce qu’absurdes comme « le nombre 2 est vert »). [less ▲]

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See detailANIMA: A data-sharing initiative for neuroimaging meta-analyses
Reid, Andrew T.; Bzdok, Danilo; Genon, Sarah ULg et al

in NeuroImage (2016)

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See detailCompte rendu, La mise en scène des produits et des marques. Représentations,significations, publics
Duchesne, Caroline ULg

in Questions de Communication (2016), 28

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps ... [more ▼]

Actes d’un colloque interdisciplinaire organisé en juillet 2013 à l’Institut universitaire de technologie Nancy-Charlemagne, le volume rassemble douze contributions envisageant, en trois temps, l’évolution stratégique de la mise en scène des marques, la place symbolique occupée par celles-ci dans l’espace social et l’interpénétration grandissante des registres commerciaux et culturels présidant à leur positionnement stratégique. [less ▲]

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See detailMyoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer
Fahmy, Karim ULg; Gonzalez, Arnaud; Arafa, Mohammad et al

in International Journal of Cancer = Journal International du Cancer (2016), 138

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas ... [more ▼]

Pancreatic ductal adenocarcinoma is one of the most deadly forms of cancers with no satisfactory treatment to date. Recent studies have identified myoferlin, a ferlin family member, in human pancreas adenocarcinoma where its expression was associated to a bad prognosis. However, the function of myoferlin in pancreas adenocarcinoma has not been reported. In other cell types, myoferlin is involved in several key plasma membrane processes such as fusion, repair, endocytosis and tyrosine kinase receptor activity. In this study, we showed that myoferlin silencing in BxPC-3 human pancreatic cancer cells resulted in the inhibition of cell proliferation in vitro and in a significant reduction of the tumor volume in chick chorioallantoic membrane assay. In addition to be smaller, the tumors formed by the myoferlin-silenced cells showed a marked absence of functional blood vessels. We further demonstrated that this effect was due, at least in part, to an inhibition of VEGFA secretion by BxPC-3 myoferlin-silenced cells. Using immunofluorescence and electron microscopy, we linked the decreased VEGFA secretion to an impairment of VEGFA exocytosis. The clinical relevance of our results was further strengthened by a significant correlation between myoferlin expression in a series of human pancreatic malignant lesions and their angiogenic status evaluated by the determination of the blood vessel density. [less ▲]

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See detailInherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study
Cleynen, Isabelle; Boucher, Gabrielle; Jostins, Luke et al

in Lancet (2016)

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See detailLes conséquences de la philosophie
Longo, Giuseppe; Cavazzini, Andrea ULg

in Glass Bead (2016)

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See detailReconstruction of the Schmallenberg virus epidemic in Belgium: Complementary use of disease surveillance approaches
Poskin, A; Theron, Léonard ULg; Hanon, JB et al

in Veterinary Microbiology (2016), 183

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See detailChemical constituents from Erythrina droogmansiana (Fabaceae), radical scavenging and antibacterial potential of some extracts and compounds
Talla, Emmanuel; Yaya Gbaweng, Joël; Mokale, Laurel et al

in Natural Products : An Indian Journal (2016), 12(1), 12-20

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2 ... [more ▼]

A new ceramide, droogmansiamide (1), was isolated from methanolic extract of roots wood of Erythrina droogmansiana, with eight known compounds namely 3-(3’,4’-methylenedioxyphenyl)-2,3-epoxypropanol (2), erythrinasinate A (3), erythrinasinate B (4), abyssinone-IV-4'-methylether (5), erythrabyssin (6), phaseollidin (7), 4’-methoxylicoflavanone (8) and abyssinone-V-4'-methylether (9) respectively from methanolic extract of roots wood and EtOAc extract of roots bark of the same plant. Their structures were elucidated using spectroscopic methods (MS, NMR and IR) and by comparison with some data found in literature. Free radical scavenging (DPPH) and antibacterial potentials of extracts and compounds were also evaluated in this work. For radical scavenging, results showed that it is phaseollidin (7) which is responsible of radical scavenging potential in the ethyl acetate extract of roots barks with value of 1.31 mg/ml; for antibacterial, one of the tested compounds abyssinone-IV-4'-methylether (5) exhibited antibacterial activities against two strains: Providencia stuartiiATCC 29916 and Enterobacter aerogenes ATCC 13048 with MIC values of 25μg/ml. [less ▲]

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See detailThe internal consistency of the North Sea carbonate system
Salt, Lesley A.; Thomas, Helmuth; Bozec, Yann et al

in Journal of Marine Systems (2016), 157

Abstract In 2002 (February) and 2005 (August), the full suite of carbonate system parameters (total alkalinity (AT), dissolved inorganic carbon (DIC), pH, and partial pressure of \{CO2\} (pCO2) were ... [more ▼]

Abstract In 2002 (February) and 2005 (August), the full suite of carbonate system parameters (total alkalinity (AT), dissolved inorganic carbon (DIC), pH, and partial pressure of \{CO2\} (pCO2) were measured on two re-occupations of the entire North Sea basin, with three parameters (AT, DIC, pCO2) measured on four additional re-occupations, covering all four seasons, allowing an assessment of the internal consistency of the carbonate system. For most of the year, there is a similar level of internal consistency, with \{AT\} being calculated to within ± 6 μmol kg− 1 using \{DIC\} and pH, \{DIC\} to ± 6 μmol kg− 1 using \{AT\} and pH, pH to ± 0.008 using \{AT\} and pCO2, and pCO2 to ± 8 μatm using \{DIC\} and pH, with the dissociation constants of Millero et al. (2006). In spring, however, we observe a significant decline in the ability to accurately calculate the carbonate system. Lower consistency is observed with an increasing fraction of Baltic Sea water, caused by the high contribution of organic alkalinity in this water mass, not accounted for in the carbonate system calculations. Attempts to improve the internal consistency by accounting for the unconventional salinity–borate relationships in freshwater and the Baltic Sea, and through application of the new North Atlantic salinity–boron relationship (Lee et al., 2010), resulted in no significant difference in the internal consistency. [less ▲]

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See detailStaphylococcus aureus genotype B and other genotypes isolated from cow milk in European countries.
Cosandey, A.; Boss, R.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 529-40

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies, however, have demonstrated in Swiss cows that Staph. aureus isolated from ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies, however, have demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infection is genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. In addition, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. The aim of this study was to subtype strains of Staph. aureus isolated from bovine mastitic milk and bulk tank milk to obtain a unified view of the presence of bovine staphylococcal subtypes in 12 European countries. A total of 456 strains of Staph. aureus were subjected to different typing methods: ribosomal spacer PCR, detection of enterotoxin genes, and detection of gene polymorphisms (lukE, coa). Major genotypes with their variants were combined into genotypic clusters (CL). This study revealed 5 major CL representing 76% of all strains and comprised CLB, CLC, CLF, CLI, and CLR. The clusters were characterized by the same genetic properties as the Swiss isolates, demonstrating high clonality of bovine Staph. aureus. Interestingly, CLB was situated in central Europe whereas the other CL were widely disseminated. The remaining 24% of the strains comprised 41 genotypes and variants, some of which (GTAM, GTBG) were restricted to certain countries; many others, however, were observed only once. [less ▲]

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See detailDe la grammaire pure logique à la grammaire philosophique. La grammaire des concepts chez Wittgenstein
Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2016)

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See detailSurfactant-assisted ultrasonic spray pyrolysis of hematite mesoporous thin films
Henrist, Catherine ULg; Toussaint, Caroline ULg; De Vroede, Jordan et al

in Microporous and Mesoporous Materials (2016), 221

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal ... [more ▼]

Mesoporous crystalline hematite is a material difficult to prepare by soft-templating with conventional techniques, because of its high crystallization temperature associated to the crystal-to-crystal goethiteto-hematite phase transition. In a previous work, it has been reported that with very careful calcination steps, it is possible to prepare mesoporous hematite films with the spin-coating technique. However, with less conventional techniques such as surfactant-assisted ultrasonic spray pyrolysis, the deposition usually leads to non-porous oxide films or to films with interstitial porosity. In this work, we demonstrate for the first time the proof-of-concept of block-copolymer templating of hematite thin films by the ultrasonic spray pyrolysis technique. Despite the fast thermal decomposition during spray deposition, a regular, monodisperse packing of spherical pores is observed after deposition on pre-heated substrates (250 C) and after a careful post-annealing step at 470 C. Moreover, with the use of a silica scaffold, we successfully preserved porosity up to a temperature as high as 800 C. These films are highly crystalline and they are composed by randomly oriented nanocrystallites with sizes as small as 25 nm. Furthermore, we show that the crystallization evolution with temperature is influenced by the presence of the templating agent and also by the preparation technique. [less ▲]

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See detailEfficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Fafin, Coraline et al

in Journal of Nephrology (2016), 29(1), 99-103

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]

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See detailStratigraphy and depositional environments of the Late Famennian (Late Devonian) of Southern Belgium and characterization of the Strud locality
Denayer, Julien ULg; Prestianni, Cyrille; Gueriau, Pierre et al

in Geological Magazine (2016), 153(1), 112-127

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods ... [more ▼]

The Famennian (Upper Devonian, c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods. The Strud locality has yielded a diverse flora and fauna including seed-plants, tetrapods, various placoderm, actinopterygian, acanthodian and sarcopterygian fishes, crustaceans (anostracans, notostracans, conchostracans and decapods) and a putative complete insect. This fossil assemblage is one of the oldest continental – probably fresh-water – ecosystems with a considerable vertebrate and invertebrate diversity. The study of the palaeoenvironment of the Strud locality is crucial because it records one of the earliest and most important phases of tetrapod evolution that took place after their emergence but before their terrestrialization. It raises the question of environmental and ecological conditions for the Devonian aquatic ecosystem and the selection pressures occurring at the onset of tetrapod terrestrialization. The present study characterized the fluvial facies of the Upper Famennian sedimentary rocks of Strud and the surrounding areas. The exceptional preservation of arthropods and plants in the main fossiliferous layers is explained by rapid burial in the fine-grained sediment of the quiet and confined flood plain environment. Newly investigated fossiliferous sections in the Meuse–Samson area led to the description and correlation of key sections (Strud, Wierde and Jausse sections, complemented by the less continuous Haltinne, Huy and Coutisse sections). Moreover, the investigated sections allowed a review of the age of the fossiliferous horizon, which is now definitely considered to be Late Famennian in age. [less ▲]

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See detailPolytype Attainability in III-V Semiconductor Nanowires
Johansson, J.; Zanolli, Zeila ULg; Dick, K. A.

in Crystal Growth & Design (2016), 16(1), 371-379

We propose a model that explains the phenomenon of polytypism in metal particle-seeded III-V semiconductor nanowires. The model is based on classical nucleation theory, utilizing the axial next-nearest ... [more ▼]

We propose a model that explains the phenomenon of polytypism in metal particle-seeded III-V semiconductor nanowires. The model is based on classical nucleation theory, utilizing the axial next-nearest-neighbor Ising (ANNNI) model to account for interlayer interaction up to the third nearest-neighboring layer. We investigate the limits of polytypism by varying the ANNNI interaction parameters. These calculations lead to attainability diagrams, which show the regions in interaction energy space where certain polytypes can be attained given that the supersaturation is precisely tuned. We calculate the values of the ANNNI interaction parameters for six common III-V materials from first principles by means of the projector-augmented wave method. We discuss our calculated values in view of previous results. Using these calculated values in our nucleation model, our analysis suggests that besides the commonly observed 3C (zinc blende) and 2H (wurtzite) polytypes the higher order polytypes 4H and 6H can also be attained, in agreement with experimental observations. © 2015 American Chemical Society. [less ▲]

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See detailBovine Staphylococcus aureus: Subtyping, evolution, and zoonotic transfer.
Boss, R.; Cosandey, A.; Luini, M. et al

in Journal of dairy science (2016), 99(1), 515-28

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that ... [more ▼]

Staphylococcus aureus is globally one of the most important pathogens causing contagious mastitis in cattle. Previous studies using ribosomal spacer (RS)-PCR, however, demonstrated in Swiss cows that Staph. aureus isolated from bovine intramammary infections are genetically heterogeneous, with Staph. aureus genotype B (GTB) and GTC being the most prominent genotypes. Furthermore, Staph. aureus GTB was found to be contagious, whereas Staph. aureus GTC and all the remaining genotypes were involved in individual cow disease. In addition to RS-PCR, other methods for subtyping Staph. aureus are known, including spa typing and multilocus sequence typing (MLST). They are based on sequencing the spa and various housekeeping genes, respectively. The aim of the present study was to compare the 3 analytic methods using 456 strains of Staph. aureus isolated from milk of bovine intramammary infections and bulk tanks obtained from 12 European countries. Furthermore, the phylogeny of animal Staph. aureus was inferred and the zoonotic transfer of Staph. aureus between cattle and humans was studied. The analyzed strains could be grouped into 6 genotypic clusters, with CLB, CLC, and CLR being the most prominent ones. Comparing the 3 subtyping methods, RS-PCR showed the highest resolution, followed by spa typing and MLST. We found associations among the methods but in many cases they were unsatisfactory except for CLB and CLC. Cluster CLB was positive for clonal complex (CC)8 in 99% of the cases and typically positive for t2953; it is the cattle-adapted form of CC8. Cluster CLC was always positive for tbl 2645 and typically positive for CC705. For CLR and the remaining subtypes, links among the 3 methods were generally poor. Bovine Staph. aureus is highly clonal and a few clones predominate. Animal Staph. aureus always evolve from human strains, such that every human strain may be the ancestor of a novel animal-adapted strain. The zoonotic transfer of IMI- and milk-associated strains of Staph. aureus between cattle and humans seems to be very limited and different hosts are not considered as a source for mutual, spontaneous infections. Spillover events, however, may happen. [less ▲]

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See detailInvestigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions
Thiry, Justine ULg; Broze, Guy ULg; Pestieau, Aude ULg et al

in European Journal of Pharmaceutical Sciences (2016)

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See detailCritical analysis of the paramagnetic to ferromagnetic phase transition in Pr0.55K0.05Sr0.4MnO3
Thaljaoui, R.; Pękała, M.; Fagnard, Jean-François ULg et al

in Physica B: Condensed Matter (2016), 482

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See detailReview of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014
Comblain, Fanny ULg; Serisier, Samuel; Barthelemy, Nicolas ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2016), 39

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See detailPétrone et le "sardisme". Remarque à propos de la langue d'Herméros dans la Cena Trimalchionis
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2016)

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See detailGenetic diversity, Population structure, parentage analysis, and construction of core collections in the French apple germplasm based on SSR markers
Lassois, Ludivine ULg; Denancé, Caroline; Ravon, Elisa et al

in Plant Molecular Biology Reporter (2016)

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 ... [more ▼]

In-depth characterization of apple genetic resources is a prerequisite for genetic improvement and for germplasm management. In this study, we fingerprinted a very large French collection of 2163 accessions with 24 SSR markers in order to evaluate its genetic diversity, population structure and genetic relationships, to link these features with cultivar selection date or usage (old or modern, dessert or cider cultivars), and to construct core collections. Most markers were highly discriminating and powerful for varietal identification, with a probability of identity P(ID) over the 21 retained SSR loci close to 10-28. Pairwise comparisons revealed 34% redundancy and 18.5% putative triploids. The results showed that the germplasm is highly diverse with an expected heterozygosity He of 0.82 and observed heterozygosity Ho of 0.83. A Bayesian model-based clustering approach revealed a weak but significant structure in three subgroups (FST = 0.014-0.048) corresponding, albeit approximately, to the three subpopulations defined beforehand (Old Dessert, Old Cider and Moderncultivars). Parentage analyses established already known and yet unknown relationships, notably between old cultivars, with the frequent occurrence of cultivars such as ‘King of Pippin’ and ‘Calville Rouge d’Hiver’ as founders. Finally, core collections based on allelic diversity were constructed. A large dessert core collection of 278 cultivars contained 90% of the total dessert allelic diversity, whereas a dessert sub-core collection of 48 cultivars contained 71% of diversity. For cider apples, a 48-cultivars core collection contained 83% of the total cider allelic diversity. [less ▲]

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See detailContinuous-Flow N-Heterocyclic Carbene Generation and Organocatalysis
Di Marco, Lorenzo; Hans, Morgan; Delaude, Lionel ULg et al

in Chemistry : A European Journal (2016)

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a ... [more ▼]

Two methods were assessed for the generation of common N heterocyclic carbenes (NHCs) from stable imidazol(in)¬ium precursors using convenient and straightforward continuous-flow setups with either a heterogeneous inorganic base (Cs2CO3 or K3PO4) or a homoge¬neous organic base (KN(SiMe3)2). In-line quenching with carbon disulfide revealed that the homogeneous strategy was most efficient for the preparation of a small library of NHCs. The generation of free nucleophilic carbenes was next telescoped with two benchmark NHC-catalyzed reactions, namely, the transesterification of vinyl acetate with benzyl alcohol and the amidation of N-Boc-glycine methyl ester with ethanolamine. Both organocatalytic transfor¬ma¬tions proceeded with total conversion and excellent yields were achieved after extraction, showcasing the first examples of continuous-flow organocatalysis with NHCs. [less ▲]

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See detailLa correction de l’expression écrite en langue étrangère et son exploitation pédagogique. Expliciter l’implicite ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2016)

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See detailLa correction de l’expression écrite en langue étrangère et son exploitation pédagogique. Expliciter l’implicite ?
Noiroux, Kevin ULg; Simons, Germain ULg

in Les cahiers de l’Association des chercheurs et enseignants didacticiens des langues étrangères (acedle) (2016)

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See detailUnveiling Network and Service Performance Degradation in the Wild with mPlane
Casas, Pedro; Fiadino, Pierdomenico; Wassermann, Sarah ULg et al

in IEEE Communications Magazine - Network Testing Series (2016)

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity ... [more ▼]

Unveiling network and service performance issues in complex and highly decentralized systems such as the Internet is a major challenge. Indeed, the Internet is based on decentralization and diversity. However, its distributed nature leads to operational brittleness and difficulty in identifying the root causes of performance degradation. In such a context, network measurements are a fundamental pillar to shed light and to unveil design and implementation defects. To tackle this fragmentation and visibility problem, we have recently conceived mPlane, a distributed measurement platform which runs, collects and analyses traffic measurements to study the operation and functioning of the Internet. In this paper, we show the potentiality of the mPlane approach to unveil network and service degradation issues in live, operational networks, involving both fixed-line and cellular networks. In particular, we combine active and passive measurements to troubleshoot problems in end-customer Internet access connections, or to automatically detect and diagnose anomalies in Internet-scale services (e.g., YouTube) which impact a large number of end-users. [less ▲]

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See detailLoadbearing capacity criteria in fire resistance testing
Dumont, Fabien ULg; Wellens, Eric ULg; Gernay, Thomas ULg et al

in Materials and Structures (2016)

The European system for fire testing and classification of loadbearing building elements lacks consistency because the two standards that have to be applied prescribe different criteria for assessing the ... [more ▼]

The European system for fire testing and classification of loadbearing building elements lacks consistency because the two standards that have to be applied prescribe different criteria for assessing the loadbearing performance. This article analyzes the implications of the present conflict between the standard for testing and the standard for classification. The prescribed criteria for loadbearing performance are related to the exceedance of deflection and rate of deflection thresholds. A database of 46 fire resistance tests performed at the University of Liege is collected that contains the time at which these thresholds are reached in fire tests with different typologies of elements (walls, floors, columns and beams). Then, the loadbearing performance (and hence the fire resistance rating) can be derived according to the two standards. The evolutions of deflection and rate of deflection during the tests are also analyzed to gain a better understanding of the adequacy of the standards. The selection of one or the other standard affects the time at which “failure” is deemed to occur in fire tests. Statistically speaking, the difference in terms of failure time that results from using one or the other standard has a 25% probability to exceed 10%. In certain cases, this results in a difference in fire resistance rating; this was observed for 3 of the analyzed tests. The apparent contradiction in two codes in application has potential practical implications and therefore needs to be solved. The article suggests some guidelines for defining homogenized and consistent criteria. [less ▲]

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See detailProcedural learning, consolidation, and transfer of a new skill in Developmental Coordination Disorder
Lejeune, Caroline ULg; Wansard, Murielle ULg; Geurten, Marie ULg et al

in Child Neuropsychology : A Journal on Normal & Abnormal Development in Childhood & Adolescence (2016), 22(2),

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill ... [more ▼]

The aim of this study was to explore the differences in procedural learning abilities between children with DCD and typically developing children by investigating the steps that lead to skill automatization (i.e., the stages of fast learning, consolidation, and slow learning). Transfer of the skill to a new situation was also assessed. We tested 34 children aged 6–12 years with and without DCD on a perceptuomotor adaptation task, a form of procedural learning that is thought to involve the cerebellum and the basal ganglia (regions whose impairment has been associated with DCD) but also other brain areas including frontal regions. The results showed similar rates of learning, consolidation, and transfer in DCD and control children. However, the DCD children's performance remained slower than that of controls throughout the procedural task and they reached a lower asymptotic performance level; the difficulties observed at the outset did not diminish with practice. [less ▲]

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See detailEffet inflammatoire des extraits de Cupressus sempervirens planté dans l’Est de l’Algérie : du modèle murin à la stimulation des cellules BEAS-2B par l’allergène majeur Cup s 1
Bouguenoun, Imene; De Pauw-Gillet, Marie-Claire ULg; Bensakhri, Z et al

in Revue Française d'Allergologie (2016), 56

Cupressus sempervirens est l’une des espèces les plus répandues en Algérie ayant une capacité allergénique très élevée. Nous avons étudié,d’abord, comment l’instillation nasale des différentes fractions ... [more ▼]

Cupressus sempervirens est l’une des espèces les plus répandues en Algérie ayant une capacité allergénique très élevée. Nous avons étudié,d’abord, comment l’instillation nasale des différentes fractions de l’extrait pollinique de cette espèce peut moduler la réponse immunitaire chez les souris, et, ensuite, la stimulation des cellules épithéliales bronchiques humaines (BEAS-2B) par l’allergène majeur, identifié par spectrométrie de masse et purifié par chromatographie échangeuse d’ions. La sensibilisation des souris a révélé, d’une part, une diminution du nombre de neutrophiles et une augmentation des éosinophiles, et, d’autre part, une augmentation significative du total cellulaire dans le liquide du lavage bronchoalvéolaire.L’étude histologique des poumons a montré une présence d’infiltrat inflammatoire et d’oedème péri-bronchique. La spectrométrie de masse nous a permis de mettre en évidence la présence de l’allergène majeur Cup s 1 dans toutes les fractions avec une présence spécifique du Cup s 3 et Cupa 1 dans la fraction 4. Cet allergène avait le potentiel pour stimuler la libération de l’IL-8 et l’IL-6 par la ligné cellulaire, BEAS-2B, in vitro d’une manière dose-dépendante [less ▲]

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See detailNetworks of prospective thoughts: the organisational role of emotion and its impact on well-being
Demblon, Julie ULg; D'Argembeau, Arnaud ULg

in Cognition & Emotion (2016), 30

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully ... [more ▼]

Recent research has shown that many prospective thoughts are organised in networks of related events, but the relational dimensions that contribute to the formation of such networks are not fully understood. Here, we investigated the organisational role of emotion by using cues of different valence for eliciting event networks. We found that manipulating the emotional valence of cues influenced the characteristics of events within networks, and that members of a network were more similar to each other on affective components than they were to members of other networks. Furthermore, a substantial proportion of events within networks were part of thematic clusters and cluster membership significantly modulated the impact of represented events on current well-being, in part through an intensification of the emotion felt when thinking about these events. These findings demonstrate that emotion contributes to the organisation of future thoughts in networks that can affect people’s well-being. [less ▲]

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See detailLA PARTICIPATION DES USAGERS COMME LEVIER DE L’INNOVATION DANS LES SERVICES PUBLICS : LE CAS DE LA GÉOMATIQUE WALLONNE
Fallon, Catherine ULg; Calay, Vincent

in Pyramides : Revue du Laboratoire d'Etudes et de Recherches en Administration Publique (2016)

La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant ... [more ▼]

La numérisation des données géographiques est une de ces techniques récentes qui transforment à la fois la structure politico-administrative et la construction des politiques elles-mêmes en transformant le réseau d’action publique. Ces données peuvent être utilisées dans la plupart des politiques, pourvu que les questions de distribution territoriales y soient pertinentes : on parle en ce sens d’une « géomatisation » de l’action publique. Le cadre européen avec la directive INSPIRE a donné l’impulsion et définit le cadre de référence pour une refonte des processus de production et de diffusion des données géographiques numériques. Les états doivent chacun établir une infrastructure de données géographiques numériques pour assurer l’interopérabilité entre bases de données et faciliter la diffusion, la disponibilité, l'utilisation et la réutilisation de l’information géographique au niveau de leur territoire et en Europe. En Belgique, ce sont les régions - et le niveau fédéral pour ses compétences - qui ont hérité de cette responsabilité : leurs données doivent être mises à disposition des utilisateurs, qu’ils soient décideurs ou citoyens dans des formats harmonisés afin d'en faciliter l'utilisation par tous et il faut aussi définir les principes d’échange, de tarification et les conditions d’utilisation propres à faciliter l’accès aux données et aux services en ligne. Les données géographiques numérisées ont ceci de particulier qu’elles sont produites de façon décentralisées par des acteurs publics mais aussi privés, lesquels cherchent à peser sur les choix stratégiques des autorités régionales. Au niveau de la Région wallonne a été mis en place récemment un ensemble de structure de coopération avec les usagers, les entreprises, et les autorités locales. L’administration a créé en son sein des groupes de travail transversaux pour améliorer l’intégration entre les approches thématiques contrôlées par les différentes directions. Le projet d’article trouve son origine dans l’accompagnement assuré par le SPIRAL au Département de la géomatique de la Région wallonne dans le cadre de la rédaction du plan stratégique et du plan opérationnel de la géomatique wallonne (2013-2015). L’article prendra appui sur les principes de la sociologie de la traduction (Callon, 1986) pour proposer une analyse des lieux et des processus qui contribuent à mettre en place une « gouvernance en réseau » mobilisant une logique d’innovation publique (Sørensen et al. 2011), sans suspendre pour autant les formes de coordination hiérarchiques et contractuelles. [less ▲]

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See detailReview of Véronique Maisier’s Violence in Caribbean Literature: Stories of Stones and Blood
Ledent, Bénédicte ULg

in Nieuwe West-Indische Gids = New West Indian Guide (2016), 90(3&4),

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See detailEffects of Dairy Products Consumption on Health: Benefits and Beliefs-A Commentary from the Belgian Bone Club and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases.
Rozenberg, Serge; Body, Jean-Jacques; Bruyère, Olivier ULg et al

in Calcified Tissue International (2016), 98(1), 1-17

Dairy products provide a package of essential nutrients that is difficult to obtain in low-dairy or dairy-free diets, and for many people it is not possible to achieve recommended daily calcium intakes ... [more ▼]

Dairy products provide a package of essential nutrients that is difficult to obtain in low-dairy or dairy-free diets, and for many people it is not possible to achieve recommended daily calcium intakes with a dairy-free diet. Despite the established benefits for bone health, some people avoid dairy in their diet due to beliefs that dairy may be detrimental to health, especially in those with weight management issues, lactose intolerance, osteoarthritis, rheumatoid arthritis, or trying to avoid cardiovascular disease. This review provides information for health professionals to enable them to help their patients make informed decisions about consuming dairy products as part of a balanced diet. There may be a weak association between dairy consumption and a possible small weight reduction, with decreases in fat mass and waist circumference and increases in lean body mass. Lactose intolerant individuals may not need to completely eliminate dairy products from their diet, as both yogurt and hard cheese are well tolerated. Among people with arthritis, there is no evidence for a benefit to avoid dairy consumption. Dairy products do not increase the risk of cardiovascular disease, particularly if low fat. Intake of up to three servings of dairy products per day appears to be safe and may confer a favourable benefit with regard to bone health. [less ▲]

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See detailInvolvement of Executive Functions in Children’s Metamemory
Geurten, Marie ULg; Catale, Corinne ULg; Meulemans, Thierry ULg

in Applied Cognitive Psychology (2016), 30(1), 70-80

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were ... [more ▼]

This experiment examined how knowledge of memory strategies and of memory functioning improves during childhood and what variables are involved in this development. Three main aspects of metamemory were assessed based on the performance of a group of 100 children (aged 4, 6, 9 and 11 years) on a battery of executive tasks. At the same time, the influence of variables such as intelligence, vocabulary and parental education level was also investigated. Results of mediation analyses reveal that the relation between children’s age and internal strategy knowledge was partially mediated by working memory skills but that executive functions did not mediate the impact of chronological age on children’s knowledge of external strategies or of memory functioning. Additionally, verbal fluency predicted internal and external strategy knowledge. Implications for general learning theories in childhood are discussed [less ▲]

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See detailCompte-rendu de l'ouvrage Cluny. Les moines et la société au premier age féodal
George, Philippe ULg

in Revue d'Histoire Ecclésiastique (2016)

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See detailDes situations-limites au dépassement de la situation : phénoménologie d'un concept sartrien
Cormann, Grégory ULg; Englebert, Jérôme ULg

in Sartre Studies International (2016), 22(1),

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant ... [more ▼]

Dans cet article, nous explorons le concept de situation, en-deçà et au-delà de sa thématisation par Sartre, à partir de L’imaginaire, dans les Carnets de la drôle de guerre puis dans L’être et le néant. Notre approche se fonde sur un double mouvement : d’une part, une archéologie du concept dans le contexte de la première percée de la phénoménologie en France dans les années 1930 ; d’autre part, une attention à son possible dépassement deux décennies plus tard. Dans une relation serrée avec les développements de la psychopathologie de son temps, il s’agit d’abord de situer la prétention de l’Esquisse d’une théorie des émotions à poser les bases d’une phénoménologie de « l’homme en situation », ensuite d’éclairer la reprise critique du concept dans Questions de méthode, dans l’exposition de la méthode progressive-régressive. En somme, il s’agit de montrer comment s’élabore progressivement chez Sartre une « herméneutique de l’existence » qui fait droit à la liberté, puis se donne les moyens d’en suivre l’action effective dans le monde. [less ▲]

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See detailThe Medium is the Message. Olivier Schrauwen's ‘Arsène Schrauwen’ Beyond Expectations of Autobiography, Colonial History and the Graphic Novel
Crucifix, Benoît ULg; Meesters, Gert

in European Comic Art (2016), 9(1),

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the ... [more ▼]

This article proposes a close reading of Olivier Schrauwen's Arsène Schrauwen, focusing on the various cultural discourses that it engages with, and particularly its ironical self-positioning within the field of comics. First of all, Schrauwen playfully questions the entrenchment of autobiography in the contemporary graphic novel by presenting a wholly fantasized adventure as biographical family history. This play with generic expectations is continued through Schrauwen’s reliance on the tropes of the adventure story and its figuration of the voyage. Arsène Schrauwen also draws on stereotypical images of both Belgium and the Belgian Congo and integrates them into a grotesque narrative so as to question the supposed unicity of the individual and colonial bodies. Last but not least, the book displays a highly self-reflexive approach to comics storytelling, building on a legacy from Flemish comics in order to play with reading conventions, graphic enunciation and abstraction, thereby thematising the perception of the main character. [less ▲]

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See detailMethods of ex vivo expansion of human cord blood cells: challenges, successes and clinical implications
Baron, Frédéric ULg; Ruggeri, A.; Nagler, A.

in Expert Review of Hematology (2016), 21

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low ... [more ▼]

More than 40,000 unrelated cord blood transplantations (UCBT) have been performed worldwide as treatment for patients with malignant or non-malignant life threatening hematologic disorders. However, low absolute numbers of hematopoietic stem and progenitor cells (HSPCs) within a single cord blood unit has remained a limiting factor for this transplantation modality, particularly in adult recipients. Further, because UCB contains low numbers of mostly naïve T cells, immune recovery after UCBT is slow predisposing patients to severe infections. Other causes of UCBT failure has included graft-versus-host disease (GVHD), and relapse of the underlying disease. In this article, we first review the current landscape of cord blood engineering aimed at improving engraftment. This includes approaches of UCB-HSPCs expansion and methods aimed at improving UCB-HSCPs homing. We then discuss recent approaches of cord blood engineering developed to prevent infection (generation of multivirus-specific cytotoxic T cells (VSTs) from UCB), relapse (transduction of UCB-T cells with tumor-specific chimeric receptor antigens (CARs)) and GVHD (expansion of regulatory T cells from UCB). Although many of these techniques of UCB engineering remain currently technically challenging and expensive, they are likely to revolutionize the field of UCBT in the next decades. [less ▲]

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