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See detailLittérature et sémiotique: histoire et épistémologie
Provenzano, François ULg; Bertrand, Jean-Pierre ULg; Stienon, Valérie ULg

in Signata. Annales des Sémiotiques = Annals of Semiotics (2015), 5(2014), 384

La question des liens entre sémiotique et littérature amène à poser un regard rétrospectif sur une période qui paraît aujourd’hui révolue. L’émergence de la sémiotique comme discipline institutionnalisée ... [more ▼]

La question des liens entre sémiotique et littérature amène à poser un regard rétrospectif sur une période qui paraît aujourd’hui révolue. L’émergence de la sémiotique comme discipline institutionnalisée est en effet contemporaine d’un profond changement de paradigme dans les approches du texte littéraire. Au cours de la décennie 1960, la rencontre entre sémiotique et littérature produit, en un temps très bref, un nombre considérable de concepts et d’instruments d’analyse, qui vont de la théorie du dialogisme et de la polyphonie à la sémanalyse en passant par la narratologie et la sémantique structurale. L'objectif de ce dossier est de saisir cette rencontre dans la perspective d’une histoire des idées, en éclairant ce qui, dans la conjoncture des années 1960, a pu favoriser la convergence, avant de la rendre caduque ou obsolète. Une place est également réservée aux témoignages pour laisser entendre, dans un souci d'historicisation, la voix d'acteurs importants de ces années sémio-littéraires: Philippe Hamon, le groupe Mu, Marc Angenot [less ▲]

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See detailA one-step short-time synthesis of Ag@SiO2 core-shell nanoparticles
Lismont, Marjorie ULg; Pàez Martinez, Carlos ULg; Dreesen, Laurent ULg

in Journal of Colloid & Interface Science (2015)

A performance of shell-thickness precise control in silver-silica coating core-shell nanoparticles is presented. 60 nm sized citrate-stabilized silver nanoparticles are directly silica coated using a ... [more ▼]

A performance of shell-thickness precise control in silver-silica coating core-shell nanoparticles is presented. 60 nm sized citrate-stabilized silver nanoparticles are directly silica coated using a modified Stöber process. Tetraethyl orthosilicate is used as a silica precursor and ammonium hydroxide as catalyst in an alcoholic solvent to promote the seeded silica growth. By simply varying the synthesis reaction time from 4 to 60 minutes, the silica shell thickness is increased from 5.1 nm to 76.4 nm. This well-controlled synthesis is then transposed to 40, 80 and 100 nm sized silver cores in order to show the independence of the silica shell growth on the nanoparticle core size. Optical properties, i.e. localized surface plasmon resonance, of the produced silver-silica core-shell are also investigated. [less ▲]

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See detailIncreased tree-growth synchronization of beech (Fagus sylvatica L.) in response to climate change in northwestern Europe
Latte, Nicolas ULg; Lebourgeois, François; Claessens, Hugues ULg

in Dendrochronologia (2015), 33

To better understand how the radial growth of beech (Fagus sylvatica L.) high forests has responded to climate change, we selected 12 sites (137 trees) with optimal growing conditions along a W − E ... [more ▼]

To better understand how the radial growth of beech (Fagus sylvatica L.) high forests has responded to climate change, we selected 12 sites (137 trees) with optimal growing conditions along a W − E altitudinal gradient (67–590 m) in Belgium. We evaluated temporal changes in growth response to climate by using pointer year analysis, moving mean sensitivities (1860–2011), and moving bootstrapped correlation coefficients (1952–2011). The strongest driving climatic variables were identified by using the partial least squares method. The common patterns of growth trends, pointer years, and mean sensitivities among sites provided evidences for the impact of environmental changes operating at a regional scale. The results of growth–climate analysis indicated that these changes were strongly influenced by the climatic conditions of the previous year. The climate sensitivity of beech increased progressively in response to more frequent and intense heat waves and warming-related droughts, especially during recent decades, leading to remarkable inter-site synchronization. The changes were much more pronounced for sites located in lowlands (<300 m). The differences in growth responses along the altitudinal gradient and the consequences of warming for beech growth and physiology are discussed. [less ▲]

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See detailTotal Error-Based Validation Including the Experimental Design-Based Robustness Evaluation of a Stability-Indicating Method for the Simultaneous Quantification of Hydrochlorothiazide and Valsartan in Tablet Formulations
ELKARBANE, M; AMOOD AL-KAMARANY, M; BOUCHAFRA, H et al

in Acta Chromatographica (2015), 27(2), 1-20

A gradient reversed phase high-performance liquid chromatography (RPHPLC) method with ultraviolet (UV) detection to analyze hydrochlorothiazide (HCT) and valsartan (VS) simultaneously in a tablet ... [more ▼]

A gradient reversed phase high-performance liquid chromatography (RPHPLC) method with ultraviolet (UV) detection to analyze hydrochlorothiazide (HCT) and valsartan (VS) simultaneously in a tablet formulation during forced degradation studies was developed. This method was validated using a novel approach, namely, the accuracy profile or total errors approach. The robustness of the method was evaluated using a Plackett–Burman design for eight factors. The algorithm of Dong was applied to determine the significant factor effects. The validation results showed that the method is precise (RSD: 1.14% for HCT and 0.43% for VS) and accurate (mean recovery: 99.90% for HCT and 99.98% for VS). On the other hand, the results of the robustness study showed that the type of column was the important factor which affects a number of responses, namely, the asymmetry factor (AF), retention time (RT), and resolution (RS). However, the assay results were not affected; therefore, the method can be considered robust. Finally, the method was applied to study the stability of HCT and VS under forced conditions. Significant results were obtained with basic hydrolysis, oxidation, and thermal stress, while the accelerated and acidic conditions did not affect the stability of HCT or VS. [less ▲]

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See detailSignes et jouabilité : l’interface comme outil de ludicisation
Barnabé, Fanny ULg

in Interfaces Numériques (2015), 4(1),

As shown by the recent works on the subject (Rao, 2008 ; Simonnot, 2008 ; all papers presented at the symposium Game and playability in the digital age), researchers now seem to agree on the fact that the ... [more ▼]

As shown by the recent works on the subject (Rao, 2008 ; Simonnot, 2008 ; all papers presented at the symposium Game and playability in the digital age), researchers now seem to agree on the fact that the digital has an intrinsic playability (it is “ludogenic” according to Vial, 2012) and that this property is not uninvolved with the current spread of the “gamification” or “ludification” (Genvo, 2011) phenomenons. Following these considerations, this paper aims to examine a specific angle of this privileged relationship between digital and game, namely the fundamental role played by the interfaces (both graphical and physical). We will try to demonstrate through various examples the deeply playable nature (I.e suitable to set off a playful attitude) of the different kinds of interface, but also to examine its causes: is there a structural basis that could explain this affinity with the play? With this aim in mind, theories of game (playful attitude) will be intersected with interface theories in order to demonstrate the existence of many similarities. The hypothesis that guides this work is that this transitional device’s playability owes more to its semiotic nature than to its belonging to digital. Indeed, as a system of signs, the interface has two characteristics that make it fit to generate a playful attitude in the user: the metaphoric distance and the increase of possible actions. [less ▲]

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See detailWasabi, de Alan Pauls. Una lectura alegórica en clave autoficcional.
Vanden Berghe, Kristine ULg

in Pasavento. Revista de Estudios Hispánicos. (2015)

Se lee Wasabi (Alan Pauls, 1994, 2005) como una novela neofantástica emparentada con La metamorfosis de Kafka y ciertos cuentos de Cortázar. Asimismo, se procede a una lectura de la novela en clave ... [more ▼]

Se lee Wasabi (Alan Pauls, 1994, 2005) como una novela neofantástica emparentada con La metamorfosis de Kafka y ciertos cuentos de Cortázar. Asimismo, se procede a una lectura de la novela en clave alegórica, atendiendo a una serie de metáforas (quiste, narcolepsias, wasabi) que aluden a las relaciones entre literatura y vida. En este sentido, se aborda el texto como una alegoría primero de la autoficción y luego de la creación literaria en general. A esta lectura alegórica la apoyan la recurrencia de la cifra siete en la novela así como la relación intertitular que esta tiene con Fils, novela autoficcional que Serge Doubrovsky escribiera en 1977. [less ▲]

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See detailStochastic modelling of reservoir sedimentation in a semi-arid watershed
Adam, Nicolas; Erpicum, Sébastien ULg; Archambeau, Pierre ULg et al

in Water Resources Management (2015), 29(3), 785-800

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real ... [more ▼]

Sedimentation in large reservoirs is a major concern in semi-arid regions characterized by severe seasonal water scarcity. As a contribution to improved sediment management, this study analyses the real case of the reservoir of Sidi Yacoub in the north of Algeria. First, a dynamic model of the reservoir was set up and used to estimate past water and sediment inflows (period 1990-2010) based on data recorded by the dam operator and measurements at a gauging station located downstream of the reservoir. Second, in a stochastic framework using the statistical characteristics of inflow and outflow discharges, a projection of future sedimentation was performed until 2030, assuming stationarity of the statistical distributions. Third, the model was used to investigate the influence of possible climate change and to quantify the positive effects of soil conservation measures upstream. [less ▲]

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See detailB fields in OB stars (BOB): on the detection of weak magnetic fields in the two early B-type stars beta CMa and epsilon CMa
Fossati, L.; Castro, N.; Morel, Thierry ULg et al

in Astronomy and Astrophysics (2015), 574

Within the context of the "B fields in OB stars (BOB)" collaboration, we used the HARPSpol spectropolarimeter to observe the early B-type stars beta CMa (HD44743; B1 II/III) and epsilon CMa (HD52089; B1.5 ... [more ▼]

Within the context of the "B fields in OB stars (BOB)" collaboration, we used the HARPSpol spectropolarimeter to observe the early B-type stars beta CMa (HD44743; B1 II/III) and epsilon CMa (HD52089; B1.5 II). For both stars, we consistently detected the signature of a weak (<30 G in absolute value) longitudinal magnetic field. We determined the physical parameters of both stars and characterise their X-ray spectrum. For beta CMa, our mode identification analysis led to determining a rotation period of 13.6+/-1.2 days and of an inclination angle of the rotation axis of 57.6+/-1.7 degrees, with respect to the line of sight. On the basis of these measurements and assuming a dipolar field geometry, we derived a best fitting obliquity of ~22 degrees and a dipolar magnetic field strength (Bd) of ~100 G (60<Bd<230 G within 1 sigma), below what is typically found for other magnetic massive stars. For epsilon CMa we could only determine a lower limit on the dipolar magnetic field strength of 13 G. For this star, we determine that the rotation period ranges between 1.3 and 24 days. Both stars are expected to have a dynamical magnetosphere. We also conclude that both stars are most likely core hydrogen burning and that they have spent more than 2/3 of their main sequence lifetime. A histogram of the distribution of the dipolar magnetic field strength for the magnetic massive stars known to date does not show the magnetic field "desert" observed instead for intermediate-mass stars. The biases involved in the detection of (weak) magnetic fields in massive stars with the currently available instrumentation and techniques imply that weak fields might be more common than currently observed. Our results show that, if present, even relatively weak magnetic fields are detectable in massive stars and that more observational effort is probably still needed to properly access the magnetic field incidence. [less ▲]

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See detailA revised DR Congo mining code could lead to a decrease in Chinese investment in the country
Wintgens, Sophie ULg

in Africa at LSE (2015)

As China shows indications of being willing to fall in line with international standards on procuring conflict minerals, this article examines the strategic issues facing China as DR Congo seeks to revise ... [more ▼]

As China shows indications of being willing to fall in line with international standards on procuring conflict minerals, this article examines the strategic issues facing China as DR Congo seeks to revise its mining code. [less ▲]

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See detailImpact of roughness and circularity-defect on bridge cables stability
Benidir, Adel; Flamand, Olivier; Gaillet, Laurent et al

in Journal of Wind Engineering & Industrial Aerodynamics (2015), 137

The stay cables on cable-stayed bridges have been the subject of considerable research in order to understand the origins of the dry galloping phenomenon. Surface irregularity is one of the last ... [more ▼]

The stay cables on cable-stayed bridges have been the subject of considerable research in order to understand the origins of the dry galloping phenomenon. Surface irregularity is one of the last parameters that have not been thoroughly examined. This paper focuses on static wind tunnel tests on original High Density Polyethylene cable covers in a range of Reynolds numbers from the sub-critical regime to the critical, corresponding to values ranging from Re = 9.6x104 to Re = 3.3x105. The experiment consists in testing cable covers of various diameters in order to investigate the effect of surface irregularity (roughness and circularity defect) on the mechanism of dry galloping excitation. Previous studies reported that dry galloping is caused by the appearance of a negative pressure bubble on one side of the circular cylinder at the critical Reynolds number range, leading to a rapid drop in the drag coefficient and the appearance of a non-negligible lift force. The results of the present investigation demonstrate that there is a clear correlation between the single bubble pressure pattern and the circularity defect along the tube. They further show that surface roughness has little effect on the location of the bubble. The paper also treats the spatial and temporal correlation of the instantaneous pressure pattern along the tube with respect to the circularity defect. [less ▲]

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See detailLe rythme vidéoludique comme mouvement : "Second Sight" et la ritournelle
Dupont, Bruno ULg

in Interval(le)s (2015), 7

Dans cet article, Bruno Dupont part de la constatation que la notion de rythme est omnipré- sente dans les descriptions et analyses de jeux vidéo, sans pour autant qu'il ait été tenté jusqu'ici de ... [more ▼]

Dans cet article, Bruno Dupont part de la constatation que la notion de rythme est omnipré- sente dans les descriptions et analyses de jeux vidéo, sans pour autant qu'il ait été tenté jusqu'ici de développer un concept de rythme qui soit adapté à la recherche. Partant de l'article bien connu de Benveniste sur l'étymologie du rythmos, de même que de la conception nonbinaire du rythme chez Deleuze et Guattari, exposée dans le chapitre de Mille plateaux consacré à la ritournelle, l'auteur souhaite fournir les prolégomènes d'un tel concept. En guise de support à sa démonstration, il utilise le jeu Second Sight sur Playstation 2 (2004). Cette contribution souligne qu'une théorie du rythme suppose l'analyse des séquences de mouvements produites par l'interaction entre jeu et joueur, ainsi que de la gestion du temps qui en découle. Dans le cas de Second Sight, en raison de la double appartenance générique du jeu (action et aventure), deux séquences motrices hétérogènes se trouvent coordonnées au sein d'un seul et même jeu, de sorte que naît une zone de friction, – que Dupont décrit à la suite de Deleuze/Guattari comme „entre-deux“ – dans laquelle le rythme spécifique au jeu, mais également au genre, se réalise par l'échange permanent entre deux modes spatio-temporels. En conclusion, l'auteur propose une définition du rythme vidéoludique qui place la machine et le joueur dans un contexte d'interaction et de négociation dynamique. [less ▲]

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See detailValidating the use of an ultra-performance liquid chromatography with tandem mass spectrometry method to quantify equol in cow's milk
Daems, Frédéric ULg; Jasselette, Christophe; Romnee, Jean-Michel et al

in Dairy Science & Technology (2015)

Cow’s milk can be used as a potential source of equol in the human diet. In order to study human intake, however, it is necessary to develop a reliable and sensitive analytical method. This paper reports ... [more ▼]

Cow’s milk can be used as a potential source of equol in the human diet. In order to study human intake, however, it is necessary to develop a reliable and sensitive analytical method. This paper reports on the validation of an analytical method using ultra-performance liquid chromatography coupled with a tandem mass spectrometry detector to quantify the equol in commercial milks (raw, whole, semi-skimmed, and skimmed milk). The equol was initially released using enzymatic hydrolysis, and it was then extracted using a double liquid/liquid extraction. The analytical method produced a linear calibration curve with a high correlation coefficient (R 2 ≥ 0.996) between 5 and 1,000 ng.mL−1. Good intra- and inter-day precision (≤5.3% and ≤ 5.2%, respectively) and accuracy (≤8.6%) were achieved. The recovery rate differed slightly among the different types of milk, ranging between 60.6 ± 1.09% and 82.3 ± 5.21%. Good method repeatability was observed (<15%). There was neither matrix effect nor carry-over effect, and the sample extracts were stable for at least 7 days of storage at −21 °C and 5 °C. The method proved to be specific, sensitive, precise, and accurate and was used for the first time to quantify the equol content in Belgian commercial cow’s milk. In all the samples analyzed, equol was present at a concentration ≥10 ng.mL−1 and had a significantly higher content in organic than in conventional milk. The study also found that the mean concentrations of equol were similar for each type of commercial conventional cow’s milk. [less ▲]

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See detailTransfer of communication skills to the workplace: Impact of a 38-hour communication skills training program designed for radiotherapy teams
Merckaert, Isabelle; Delevallez, France; Gibon, Anne-Sophie et al

in Journal of Clinical Oncology (2015)

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See detailThe reliability of isoinertial force-velocity-power profiling and maximal strength assessment in youth.
Meylan, César; Cronin, John; Oliver, Jon et al

in Sports Biomechanics (2015)

The purpose of this study was to quantify the inter-session reliability of force-velocity-power profiling and estimated maximal strength in youth. Thirty-six males (11-15 years old) performed a ballistic ... [more ▼]

The purpose of this study was to quantify the inter-session reliability of force-velocity-power profiling and estimated maximal strength in youth. Thirty-six males (11-15 years old) performed a ballistic supine leg press test at five randomized loads (80%, 100%, 120%, 140%, and 160% body mass) on three separate occasions. Peak and mean force, power, velocity, and peak displacement were collected with a linear position transducer attached to the weight stack. Mean values at each load were used to calculate different regression lines and estimate maximal strength, force, velocity, and power. All variables were found reliable (change in the mean [CIM] = - 1 to 14%; coefficient of variation [CV] = 3-18%; intraclass correlation coefficient [ICC] = 0.74-0.99), but were likely to benefit from a familiarization, apart from the unreliable maximal force/velocity ratio (CIM = 0-3%; CV = 23-25%; ICC = 0.35-0.54) and load at maximal power (CIM = - 1 to 2%; CV = 10-13%; ICC = 0.26-0.61). Isoinertial force-velocity-power profiling and maximal strength in youth can be assessed after a familiarization session. Such profiling may provide valuable insight into neuromuscular capabilities during growth and maturation and may be used to monitor specific training adaptations. [less ▲]

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See detailFighting Poor Quality Medicines: Develop-ment, Transfer and Validation of Generic HPLC Methods for Analyzing two WHO Recommended Antimalarial Tablets
Mbinze Kindenge, Jérémie; Yemoa, Achille; Lebrun, Pierre ULg et al

in American Journal of Analytical Chemistry (2015), 6

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative ... [more ▼]

As serious but neglected public health problems, poor quality medicines, i.e. for antimalarial medicines, urged to be fought. One of the approaches is to consider the analytical chemistry and separative techniques. In this study, a generic liquid chromatographic method was firstly devel-oped for the purpose of screening 8 antimalarial active ingredients, namely amodiaquine (AQ), piperaquine (PPQ), sulfalene (SL), pyrimethamine (PM), lumefantrine (LF), artesunate (AS), artemether (AM) and dihydroartemisinine (DHA) by applying DoE/DS optimization strategy. Since the method was not totally satisfying in terms of peak separation, further experiments were undergone applying the same development strategy while splitting the 8 ingredients into five groups. Excellent prediction was observed prior to correlation between retention times of predicted and observed separation conditions. Then, a successful geometric transfer was realized to reduce the analysis time focusing on the simultaneous quantification of two WHO's recommended ACTs in anti-malarial fixed-dose combination (AM-LF and AS-AQ) in tablets. The optimal separation was achieved using an isocratic elution of methanol-ammonium formate buffer (pH 2.8; 10mM) (82.5: 17.5, v/v) at 0.6ml/min through a C18 column (100mm×3.5mm, 3.5 μm) thermostated at 25°C. After a successful validation stage based on the total error approach, the method was applied to determine the content of AM/LF or AS/AQ in seven brands of antimalarial tablets currently marketed in West, Central and East Africa. Satisfying results were obtained compared to the claimed contents. [less ▲]

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See detailApplication of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines
Mbinze, Kingenge; Nsangu Mpasi, Jean; Maghe, Elza et al

in American Journal of Analytical Chemistry (2015), 6

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric ... [more ▼]

In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2-10µg/mL (for quinine sulfate in tablet), 4-12µg/mL (for quinine bichlorhydrate in oral drop - metronidazole benzaote in oral suspension) and 15-35µg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms. [less ▲]

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See detailPurinergic control of inflammation and thrombosis: Role of P2X1 receptors
Oury, Cécile ULg; LECUT, Christelle ULg; Hego, Alexandre ULg et al

in Computational and Structural Biotechnology Journal (2015), 13

Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between ... [more ▼]

Inflammation shifts the hemostatic mechanisms in favor of thrombosis. Upon tissue damage or infection, a sudden increase of extracellular ATP occurs, that might contribute to the crosstalk between inflammation and thrombosis. On platelets, P2X1 receptors act to amplify platelet activation and aggregation induced by other platelet agonists. These receptors critically contribute to thrombus stability in small arteries. Besides platelets, studies by our group indicate that these receptors are expressed by neutrophils. They promote neutrophil chemotaxis, both in vitro and in vivo. In a laser-induced injury mouse model of thrombosis, it appears that neutrophils are required to initiate thrombus formation and coagulation activation on inflamed arteriolar endothelia. In thismodel, by using P2X1−/−mice,we recently showed that P2X1 receptors, expressed on platelets and neutrophils, play a key role in thrombus growth and fibrin generation. Intriguingly, in a model of endotoxemia, P2X1−/−mice exhibited aggravated oxidative tissue damage, along with exacerbated thrombocytopenia and increased activation of coagulation, which translated into higher susceptibility to septic shock. Thus, besides its ability to recruit neutrophils and platelets on inflamed endothelia, the P2X1 receptor also contributes to limit the activation of circulating neutrophils under systemic inflammatory conditions. Taken together, these data suggest that P2X1 receptors are involved in the interplay between platelets, neutrophils and thrombosis. We propose that activation of these receptors by ATP on neutrophils and platelets represents a new mechanism that regulates thrombo-inflammation. [less ▲]

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See detailLow molecular weight poly (2-dimethylamino ethylmethacrylate) polymers with controlled positioned fluorescent labeling: Synthesis, characterization and in vitro interaction with human endothelial cells.
Flebus, Luca ULg; Lombart, François ULg; Sevrin, Chantal et al

in International journal of pharmaceutics (2015), 478(1), 278-287

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical ... [more ▼]

Poly (2-dimethylamino ethylmethacrylate) (PDMAEMA) is an attractive non-degradable polymer studied as nonviral vector for gene delivery but it can be also adopted for delivery of other biopharmaceutical drugs. As a parenteral carrier, the PDMAEMA free form (FF) might interact with tissues and cells. Few data are available on its selective internalization and efflux from cells, while the majority of studies published have followed the distribution of DNA complexed with PDMAEMA. In order to address polycation safety, the first aim was to synthesize by atom transfer radical polymerisation (ATRP) fluorescent labeled PDMAEMA of low molecular weight (Mw) (below 15kDa), controlling the position and density of fluorescein. The second goal was to analyze the possible difference in uptake and subcellular distribution of this labeled FF polycation between human umbilical vein endothelial cells (HUVEC) and hCMEC/D3 cells. These two cell lines have been chosen in order to detect selectivity towards the blood-brain barrier (BBB). In both cases, polycation was detected along the plasma membrane followed by progressive migration to the peri-nuclear region, where it overlapped with lysosomal structures. The analysis by fluorescence-activated cell sorting (FACS) of the PDMAEMA uptake by hCMEC/D3 cells showed a significant (p<0.05) inhibition (40%) in presence of 2-dexoxy-d-glucose inhibitor, a result supporting an energy-dependence mechanism(s). Cytotoxicity study showed that low Mw PDMAEMA (10kDa) lead to a minor cytotoxicity compared to the higher ones. As main conclusion this study highlights the similitude in cell trafficking of FF PDMAEMA and data previously reported for PDMAEMA/DNA complexes. [less ▲]

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See detail(Tissue PET) Vascular metabolic imaging and peripheral plasma biomakers in the evolution of chronic arotic dissections
SAKALIHASAN, Natzi ULg; NIENABER, Christoph; HUSTINX, Roland ULg et al

in European Heart Journal - Cardiovascular Imaging (2015)

Enhanced FDG uptake may be considered as a complementary imaging marker associated with secondary complications in type B dissections. During follow-up, aneurysmal progression is related to PET/CT and ... [more ▼]

Enhanced FDG uptake may be considered as a complementary imaging marker associated with secondary complications in type B dissections. During follow-up, aneurysmal progression is related to PET/CT and biomarkers of thrombus renewal and lysis. [less ▲]

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See detailSymmetry breaking patterns in 3HDM
Ivanov, Igor ULg; Nishi, Celso

in Journal of High Energy Physics [=JHEP] (2015), 15

An attractive feature of New Physics models with multiple Higgs fields is that they are equipped with discrete symmetry groups in the Higgs and flavour sectors. These symmetry groups are often broken at ... [more ▼]

An attractive feature of New Physics models with multiple Higgs fields is that they are equipped with discrete symmetry groups in the Higgs and flavour sectors. These symmetry groups are often broken at the global minimum of the Higgs potential, either completely or to a proper subgroup, with certain phenomenological consequences. Here, we systematically explore these symmetry breaking patterns in the scalar sector of the three-Higgs-doublet model (3HDM). We use the full list of discrete symmetry groups allowed in 3HDM, and for each group we find all possible ways it can break by the Higgs vacuum expectation value alignment. We also discuss the interplay between these symmetry groups and various forms of CP-violation in the scalar sector of 3HDM. Not only do our results solve the problem for 3HDM, but they also hint at several general features in multi-scalar sectors. [less ▲]

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See detailRecent summer Arctic atmospheric circulation anomalies in a historical perspective
Belleflamme, Alexandre ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

in Cryosphere (The) (2015), 9

A significant increase in the summertime occurrence of a high pressure area over the Beaufort Sea, the Canadian Arctic Archipelago, and Greenland has been observed since the beginning of the 2000s, and ... [more ▼]

A significant increase in the summertime occurrence of a high pressure area over the Beaufort Sea, the Canadian Arctic Archipelago, and Greenland has been observed since the beginning of the 2000s, and particularly between 2007 and 2012. These circulation anomalies are likely partly responsible for the enhanced Greenland ice sheet melt as well as the Arctic sea ice loss observed since 2007. Therefore, it is interesting to analyse whether similar conditions might have happened since the late 19th century over the Arctic region. We have used an atmospheric circulation type classification based on daily mean sea level pressure and 500 hPa geopotential height data from five reanalysis data sets (ERA-Interim, ERA-40, NCEP/NCAR, ERA-20C, and 20CRv2) to put the recent circulation anomalies in perspective with the atmospheric circulation variability since 1871. We found that circulation conditions similar to 2007–2012 have occurred in the past, despite a higher uncertainty of the reconstructed circulation before 1940. For example, only ERA-20C shows circulation anomalies that could explain the 1920–1930 summertime Greenland warming, in contrast to 20CRv2. While the recent anomalies exceed by a factor of 2 the interannual variability of the atmospheric circulation of the Arctic region, their origin (natural variability or global warming) remains debatable. [less ▲]

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See detailClostridium difficile from food and surface samples in a Belgian nursing home: An unlikely source of contamination
Rodriguez Diaz, Cristina ULg; Korsak Koulagenko, Nicolas ULg; Taminiau, Bernard ULg et al

in Anaerobe (2015), 32

This study investigates the contamination of foods and surfaces with Clostridium difficile in a single nursing home. C. difficile PCR-ribotype 078 was found in one food sample and in none of the tested ... [more ▼]

This study investigates the contamination of foods and surfaces with Clostridium difficile in a single nursing home. C. difficile PCR-ribotype 078 was found in one food sample and in none of the tested surfaces. These results indicate that food and surfaces are an unlikely source of C. difficile infection in this setting. [less ▲]

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See detailAssociation of Cerebrospinal Fluid Prion Protein Levels and the Distinction Between Alzheimer Disease and Creutzfeldt-Jakob Disease
Dorey, Aline; Tholance, Yannick; Vighetto, Alain et al

in JAMA Neurology (2015)

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological ... [more ▼]

IMPORTANCE Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypesmay pose a diagnostic challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia presentation. OBJECTIVE To assess the relevance of total CSF prion protein (t-PrP) levels in the differential biological diagnosis between atypical AD phenotypes and CJD. DESIGN, SETTING, AND PARTICIPANTS A retrospective study in an autopsy-confirmed cohort of 82 patients was performed to evaluate the relevance of CSF t-PrP to distinguish 30 definite cases of AD from 52 definite cases of CJD. Next, CSF t-PrP concentration was measured in a cohort of 104 patients including 55 patients with probable AD, 26 with probable sporadic CJD, and 23 control patients for whom 14-3-3 protein, total tau, phosphorylated tau 181 (P-tau181), and Aβ1-42 were available.We investigated 46 patients diagnosed as having probable AD who presented atypical phenotypes. A diagnosis strategy was proposed to classify atypical AD phenotypes with suspicion of CJD based on a decision tree combining CSF biomarkers. MAIN OUTCOMES AND MEASURES We determined CSF t-PrP levels for all patients.We calculated the ratio of total tau and P-tau181 and determined the diagnostic accuracy of each biomarker alone or in combination.We calculated the misclassification rate for each biomarker that corresponded to the percentage of patients within the group of atypical AD phenotypes wrongly classified as CJD. RESULTS In patients with CJD, CSF t-PrP concentrations were decreased compared with control participants and patients with AD. When considering the differential diagnosis of CJD compared with atypical AD phenotypes, CSF t-PrP determination reached 82.1%sensitivity and 91.3%specificity. The misclassification rate of atypical AD phenotypes decreased from 43.5%, obtained when using the CSF 14-3-3 protein determination alone, to only 4.3%when calculating the ratio total tau/(P-tau181 × t-PrP). The proposed classification tree permitted correct classification of 98.4%of the patients. CONCLUSIONS AND RELEVANCE For unusual phenotypes of AD, especially cases presenting with a biological ambiguity suggesting CJD, determination of CSF t-PrP levels increased diagnostic accuracy. The use of CSF t-PrP levels may be beneficial in clinical practice in [less ▲]

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See detailHigh-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
Goyette, Philippe; Boucher, Gabrielle; Mallon, D et al

in Nature Genetics (2015)

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major ... [more ▼]

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD. [less ▲]

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See detailUpscaling of an electronic nose for continuously stirred tank reactor stability monitoring from pilot-scale to real-scale agricultural co-digestion biogas plant
Adam, Gilles ULg; Lemaigre, Sébastien; Goux, Xavier et al

in Bioresource Technology (2015), 178

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to ... [more ▼]

This study investigated the use of an electronic nose for on-line anaerobic reactor state monitoring at the pilot-scale level and then upscaling to the full-scale level. E-nose indicator was compared to classical state indicators such as pH, alkalinity, volatile fatty acids concentration and to other gas phase compounds. Multivariate statistical process control method, based on principal component analysis and the Hotelling's T² statistics was used to derive an indicator representative of the reactor state. At the pilot-scale level, the e-nose indicator was relevant and could distinguish 3 process states: steady-state, transient and collapsing process. At the full-scale level, the e-nose indicator could provide the warning of the major disturbance whereas two slight disturbances were not detected and it gave one major false alarm. This work showed that gas phase relation with anaerobic process should be deeper investigated, as an e-nose could indicate the reactor state, focusing on the gas phase. [less ▲]

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See detailThe binary near-Earth Asteroid (175706) 1996 FG3 - An observational constraint on its orbital evolution
Scheirich, P.; Pravec, P.; Jacobson, S. A. et al

in Icarus (2015), 245

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new ... [more ▼]

Using our photometric observations taken between April 1996 and January 2013 and other published data, we derived properties of the binary near-Earth Asteroid (175706) 1996 FG<SUB>3</SUB> including new measurements constraining evolution of the mutual orbit with potential consequences for the entire binary asteroid population. We also refined previously determined values of parameters of both components, making 1996 FG<SUB>3</SUB> one of the most well understood binary asteroid systems. With our 17-year long dataset, we determined the orbital vector with a substantially greater accuracy than before and we also placed constraints on a stability of the orbit. Specifically, the ecliptic longitude and latitude of the orbital pole are 266 ° and - 83 ° , respectively, with the mean radius of the uncertainty area of 4 ° , and the orbital period is 16.1508 ± 0.0002 h (all quoted uncertainties correspond to 3σ). We looked for a quadratic drift of the mean anomaly of the satellite and obtained a value of 0.04 ± 0.20 deg /yr<SUP>2</SUP> , i.e., consistent with zero. The drift is substantially lower than predicted by the pure binary YORP (BYORP) theory of McMahon and Scheeres (McMahon, J., Scheeres, D. [2010]. Icarus 209, 494-509) and it is consistent with the tigidity and quality factor of μQ = 1.3 ×10<SUP>7</SUP> Pa using the theory that assumes an elastic response of the asteroid material to the tidal forces. This very low value indicates that the primary of 1996 FG<SUB>3</SUB> is a 'rubble pile', and it also calls for a re-thinking of the tidal energy dissipation in close asteroid binary systems. [less ▲]

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See detailCan the collapse of a fly ash heap develop into an air-fluidized flow? - Reanalysis of the Jupille accident (1961)
Stilmant, Frédéric ULg; Pirotton, Michel ULg; Archambeau, Pierre ULg et al

in Geomorphology (2015), 228

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of ... [more ▼]

A fly ash heap collapse occurred in Jupille (Liege, Belgium) in 1961. The subsequent flow of fly ash reached a surprisingly long runout and had catastrophic consequences. Its unprecedented degree of fluidization attracted scientific attention. As drillings and direct observations revealed no water-saturated zone at the base of the deposits, scientists assumed an air-fluidization mechanism, which appeared consistent with the properties of the material. In this paper, the air-fluidization assumption is tested based on two-dimensional numerical simulations. The numerical model has been developed so as to focus on the most prominent processes governing the flow, with parameters constrained by their physical interpretation. Results are compared to accurate field observations and are presented for different stages in the model enhancement, so as to provide a base for a discussion of the relative influence of pore pressure dissipation and pore pressure generation. These results show that the apparently high diffusion coefficient that characterizes the dissipation of air pore pressures is in fact sufficiently low for an important degree of fluidization to be maintained during a flow of hundreds of meters. [less ▲]

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See detailForbidden oxygen lines at various nucleocentric distances in comets
Decock, Alice ULg; Jehin, Emmanuel ULg; Rousselot, P. et al

in Astronomy and Astrophysics (2015), 573

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen ... [more ▼]

Aims: We study the formation of the [OI] lines - that is, 5577.339 Å (the green line), 6300.304 Å and 6363.776 Å (the two red lines) - in the coma of comets and determine the parent species of the oxygen atoms using the ratio of the green-to-red-doublet emission intensity, I[SUB]5577[/SUB]/(I[SUB]6300[/SUB] + I[SUB]6364[/SUB]), (hereafter the G/R ratio) and the line velocity widths. <BR /> Methods: We acquired high-resolution spectroscopic observations at the ESO Very Large Telescope of comets C/2002 T7 (LINEAR), 73P-C/Schwassmann-Wachmann 3, 8P/Tuttle, and 103P/Hartley 2 when they were close to Earth (<0.6 au). Using the observed spectra, which have a high spatial resolution (<60 km/pixel), we determined the intensities and widths of the three [OI] lines. We spatially extracted the spectra to achieve the best possible resolution of about 1-2'', that is, nucleocentric projected distances of 100 to 400 km depending on the geocentric distance of the comet. We decontaminated the [OI] green line from C[SUB]2[/SUB] lines blends that we identified. <BR /> Results: The observed G/R ratio in all four comets varies as a function of nucleocentric projected distance (between ~0.25 to ~0.05 within 1000 km). This is mainly due to the collisional quenching of O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) by water molecules in the inner coma. The observed green emission line width is about 2.5 km s[SUP]-1[/SUP] and decreases as the distance from the nucleus increases, which can be explained by the varying contribution of CO[SUB]2[/SUB] to the O([SUP]1[/SUP]S) production in the innermost coma. The photodissociation of CO[SUB]2[/SUB] molecules seem to produce O([SUP]1[/SUP]S) closer to the nucleus, while the water molecule forms all the O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) atoms beyond 10[SUP]3[/SUP] km. Thus we conclude that the main parent species producing O([SUP]1[/SUP]S) and O([SUP]1[/SUP]D) in the inner coma is not always the same. The observations have been interpreted in the framework of the previously described coupled-chemistry-emission model, and the upper limits of the relative abundances of CO[SUB]2[/SUB] were derived from the observed G/R ratios. Measuring the [OI] lines might provide a new way to determine the CO[SUB]2[/SUB] relative abundance in comets. Based on observations made with ESO Telescope at the La Silla Paranal Observatory under programs ID 073.C-0525, 277.C-5016, 080.C-0615 and 086.C-0958.Tables 3 and 4 are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424403/olm">http://www.aanda.org</A> [less ▲]

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See detailDust from Comet 209P/LINEAR during its 2014 Return: Parent Body of a New Meteor Shower, the May Camelopardalids
Ishiguro, Masateru; Kuroda, Daisuke; Hanayama, Hidekazu et al

in The Astrophysical Journal Letters (2015), 798

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was ... [more ▼]

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was apparently inactive at a heliocentric distance r<SUB>h</SUB> = 1.6 AU and showed weak activity at r<SUB>h</SUB> <= 1.4 AU. We found an active region of <0.001% of the entire nuclear surface during the comet's dormant phase. An edge-on image suggests that particles up to 1 cm in size (with an uncertainty of factor 3-5) were ejected following a differential power-law size distribution with index q = –3.25 ± 0.10. We derived a mass-loss rate of 2-10 kg s<SUP>–1</SUP> during the active phase and a total mass of ≈5 × 10<SUP>7</SUP> kg during the 2014 return. The ejection terminal velocity of millimeter- to centimeter-sized particles was 1-4 m s<SUP>–1</SUP>, which is comparable to the escape velocity from the nucleus (1.4 m s<SUP>–1</SUP>). These results imply that such large meteoric particles marginally escaped from the highly dormant comet nucleus via the gas drag force only within a few months of the perihelion passage. [less ▲]

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See detailMonte Carlo Simulation of Metastable Oxygen Photochemistry in Cometary Atmospheres
Bisikalo, D. V.; Shematovich, V. I.; Gérard, Jean-Claude ULg et al

in The Astrophysical Journal (2015), 798

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical ... [more ▼]

Cometary atmospheres are produced by the outgassing of material, mainly H[SUB]2[/SUB]O, CO, and CO[SUB]2[/SUB] from the nucleus of the comet under the energy input from the Sun. Subsequent photochemical processes lead to the production of other species generally absent from the nucleus, such as OH. Although all comets are different, they all have a highly rarefied atmosphere, which is an ideal environment for nonthermal photochemical processes to take place and influence the detailed state of the atmosphere. We develop a Monte Carlo model of the coma photochemistry. We compute the energy distribution functions (EDF) of the metastable O([SUP]1[/SUP]D) and O([SUP]1[/SUP]S) species and obtain the red (630 nm) and green (557.7 nm) spectral line shapes of the full coma, consistent with the computed EDFs and the expansion velocity. We show that both species have a severely non-Maxwellian EDF, that results in broad spectral lines and the suprathermal broadening dominates due to the expansion motion. We apply our model to the atmosphere of comet C/1996 B2 (Hyakutake) and 103P/Hartley 2. The computed width of the green line, expressed in terms of speed, is lower than that of the red line. This result is comparable to previous theoretical analyses, but in disagreement with observations. We explain that the spectral line shape does not only depend on the exothermicity of the photochemical production mechanisms, but also on thermalization, due to elastic collisions, reducing the width of the emission line coming from the O([SUP]1[/SUP]D) level, which has a longer lifetime. [less ▲]

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See detailV444 Cygni X-ray and polarimetric variability: Radiative and Coriolis forces shape the wind collision region
Lomax, J. R.; Nazé, Yaël ULg; Hoffman, J. L. et al

in Astronomy and Astrophysics (2015), 573

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind ... [more ▼]

We present results from a study of the eclipsing, colliding-wind binary V444 Cyg that uses a combination of X-ray and optical spectropolarimetric methods to describe the 3D nature of the shock and wind structure within the system. We have created the most complete X-ray light curve of V444 Cyg to date using 40 ks of new data from Swift, and 200 ks of new and archived XMM-Newton observations. In addition, we have characterized the intrinsic, polarimetric phase-dependent behavior of the strongest optical emission lines using data obtained with the University of Wisconsin's Half-Wave Spectropolarimeter. We have detected evidence of the Coriolis distortion of the wind-wind collision in the X-ray regime, which manifests itself through asymmetric behavior around the eclipses in the system's X-ray light curves. The large opening angle of the X-ray emitting region, as well as its location (i.e. the WN wind does not collide with the O star, but rather its wind) are evidence of radiative braking/inhibition occurring within the system. Additionally, the polarimetric results show evidence of the cavity the wind-wind collision region carves out of the Wolf-Rayet star's wind. [less ▲]

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See detailThe Gaia-ESO Survey: CNO abundances in the open clusters Trumpler 20, NGC 4815, and NGC 6705
Tautvaišienė, G.; Drazdauskas, A.; Mikolaitis, Š. et al

in Astronomy and Astrophysics (2015), 573

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim ... [more ▼]

Context. The Gaia-ESO Public Spectroscopic Survey will observe a large sample of clusters and cluster stars, covering a wide age-distance-metallicity-position-density parameter space. <BR /> Aims: We aim to determine C, N, and O abundances in stars of Galactic open clusters of the Gaia-ESO survey and to compare the observed abundances with those predicted by current stellar and Galactic evolution models. In this pilot paper, we investigate the first three intermediate-age open clusters. <BR /> Methods: High-resolution spectra, observed with the FLAMES-UVES spectrograph on the ESO VLT, were analysed using a differential model atmosphere method. Abundances of carbon were derived using the C[SUB]2[/SUB] band heads at 5135 and 5635.5 Å. The wavelength interval 6470-6490 Å, with CN features, was analysed to determine nitrogen abundances. Oxygen abundances were determined from the [O i] line at 6300 Å. <BR /> Results: The mean values of the elemental abundances in Trumpler 20 as determined from 42 stars are: [ Fe/H ] = 0.10 ± 0.08 (s.d.), [ C/H ] = -0.10 ± 0.07, [ N/H ] = 0.50 ± 0.07, and consequently C/N = 0.98 ± 0.12. We measure from five giants in NGC 4815: [ Fe/H ] = -0.01 ± 0.04, [ C/H ] = -0.17 ± 0.08, [ N/H ] = 0.53 ± 0.07, [ O/H ] = 0.12 ± 0.09, and C/N = 0.79 ± 0.08. We obtain from 27 giants in NGC 6705: [ Fe/H ] = 0.0 ± 0.05, [ C/H ] = -0.08 ± 0.06, [ N/H ] = 0.61 ± 0.07, [ O/H ] = 0.13 ± 0.05, and C/N = 0.83 ± 0.19. The C/N ratios of stars in the investigated open clusters were compared with the ratios predicted by stellar evolutionary models. For the corresponding stellar turn-off masses from 1.9 to 3.3 M[SUB]⊙[/SUB], the observed C/N ratio values are very close to the predictions of standard first dredge-up models as well as to models of thermohaline extra-mixing. They are not decreased as much as predicted by the recent model in which the thermohaline- and rotation-induced extra-mixing act together. The average [O/H] abundance ratios of NGC 4815 and NGC 6705 are compared with the predictions of two Galactic chemical evolution models. The data are consistent with the evolution at the solar radius within the errors. <BR /> Conclusions: The first results of CNO determinations in open clusters show the potential of the Gaia-ESO Survey to judge stellar and Galactic chemical evolution models and the validity of their physical assumptions through a homogeneous and detailed spectral analysis. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programme ID 188.B-3002 (The Gaia-ESO Public Spectroscopic Survey, PIs G. Gilmore and S. Randich). [less ▲]

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See detailSeasonal variability of meiofauna, especially harpacticoid copepods, in Posidonia oceanica macrophytodetritus accumulations
Mascart, Thibaud ULg; Lepoint, Gilles ULg; Deschoemaeker, Silke et al

in Journal of Sea Research (2015), 95

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated ... [more ▼]

The overall aim of this study was (1) to assess the diversity and density of meiofauna taxa, especially harpacticoid copepod species, present within accumulated seagrass macrophytodetritus on unvegetated sand patches and (2) to elucidate the community structure of detritus-associated harpacticoid copepods in relation to natural temporal variability of physico-chemical characteristics of accumulations. This was investigated in a Posidonia oceanica (L.) Delile seagrass ecosystem in the northwest Mediterranean Sea (Bay of Calvi, Corsica, 42°35’N, 8°43’E) using a triplicate macrophytodetritus core field sampling in two contrasting sites over the four seasons of 2011. Meiofauna higher taxa consisted of 50% Copepoda, which 87% belonged to the Harpacticoida order. Nematoda was the second most abundant taxa. The copepod community displayed a wide variety of morphologically similar and ecologically different species (i.e. mesopsammic, phytal, phytal-swimmers, planktonic and parasitic). The harpacticoid copepod community followed a strong seasonal pattern with highest abundances and species diversity in May-August, revealing a link with the leaf litter epiphyte primary production cycle. Aside from the important role in sheltering, housing and feeding potential of macrophytodetritus, a harpacticoid community BEST analysis demonstrated a positive correlation with habitat complexity and a negative correlation with water movements and P. oceanica leaf litter accumulation. [less ▲]

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See detailFeature issue of digital holography and 3D imaging (DH): introduction
Hayasaki, Yoshio; Liu, Jung-Ping; Georges, Marc ULg

in Applied Optics (2015), 54(1), 1-2

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO ... [more ▼]

The OSA Topical Meeting “Digital Holography and 3D Imaging (DH)” was held in Seattle, Washington, 13–17 July 2014. Feature issues based on the DH meeting series have been released by Applied Optics (AO) since 2007. In this year (2014), Optics Express (OE) and AO jointly decided to have one such feature issue in each journal. The feature issue includes 27 papers and covers a large range of topics, reflecting the rapidly expanding techniques and applications of digital holography and 3D imaging. The DH meeting will continue in the future, as expected, and the next meeting is scheduled to be held on24–28 May 2015, at Shanghai Institute of Optics and Fine Mechanics, Shanghai, China. [less ▲]

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See detailEvidence that Pluto's atmosphere does not collapse from occultations including the 2013 May 04 event
Olkin, C. B.; Young, L. A.; Borncamp, D. et al

in Icarus (2015), 246

Combining stellar occultation observations probing Pluto's atmosphere from 1988 to 2013, and models of energy balance between Pluto's surface and atmosphere, we find the preferred models are consistent ... [more ▼]

Combining stellar occultation observations probing Pluto's atmosphere from 1988 to 2013, and models of energy balance between Pluto's surface and atmosphere, we find the preferred models are consistent with Pluto retaining a collisional atmosphere throughout its 248-year orbit. The occultation results show an increasing atmospheric pressure with time in the current epoch, a trend present only in models with a high thermal inertia and a permanent N<SUB>2</SUB> ice cap at Pluto's north rotational pole. [less ▲]

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See detailBasin-scale partitioning of Greenland ice sheet mass balance components (2007–2011)
Andersen, M.L.; Stenseng, L.; Skourup, H. et al

in Earth and Planetary Science Letters (2015), 409

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be ... [more ▼]

The current deficit in Greenland ice sheet mass balance is due to both a decrease in surface mass balance (SMB ) input and an increase in ice discharge (D ) output. While SMB processes are beginning to be well captured by observationally-constrained climate modeling, insight into D is relatively limited. We use InSAR-derived velocities, in combination with ice thickness observations, to quantify the mass flux (F ) across a flux perimeter around the ice sheet at ∼1700 m elevation. To quantify D , we correct F for SMB , as well as changes in volume due to ice dynamics, in the area downstream of the gate. Using a 1961–1990 reference climatology SMB field from the MAR regional climate model, we quantify ice sheet mass balance within eighteen basins. We find a 2007–2011 mean D of View the MathML source. We find a 2007–2011 mean total mass balance of View the MathML source, which is equal to a 0.73 mm yr−1 global sea level rise contribution. This mass loss is dominated by SMB, which accounts for 61% of mass loss in the basins where partitioning is possible. [less ▲]

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See detailSEM and EDS observations of carrollite bioleaching with a mixed culture of acidophilic bacteria
Nkulu, Guy; Gaydardzhiev, Stoyan ULg; Mwema, Edouard et al

in Minerals Engineering (2015), doi:10.1016/j.mineng.2014.12.005

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to ... [more ▼]

Bioleaching of high purity carrollite minerals with mesophilic bacteria was carried out and monitored by observations in scanning electron microscopy (SEM) and elemental X-ray microanalysis (EDS) to provide evidence of the interaction pattern between carrollite and microorganisms. A bacterial consortium involving three different acidophilic chemolithotrophs was adopted. The evolution of the surface topography, inside alteration effects and elemental composition of the mineral with leaching time was followed. It could be postulated that bacterial adhesion takes place on the mineral surface, resulting in the formation of dissolution pits of various shapes and continues by boring elongated channels deep inside the mineral grains. Enhanced concentration of ferric iron and sulphur could be assumed in vicinity of the zones where mineralized polymer substances are precipitated. It could be inferred that carrollite dissolution is governed by cooperative bioleaching involving oxidation induced by bacteria attached to the surface and ferric iron re-oxidized by planktonic bacteria in suspension. [less ▲]

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See detailGuaranteed Conditional Performance of the S2 Control Chart with Estimated Parameters
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Woodall, William

in International Journal of Production Research (2015)

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to ... [more ▼]

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to have confidence that the in-control average run length (ARL) obtained will be near the desired value. To overcome this problem, we adjust the S2 chart controls limits such that the in-control ARL is guaranteed to be above a specified value with a certain specified probability. The required adjustment does not have too much of an effect on the out-of-control performance of the chart. [less ▲]

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See detailStimuli-responsive behavior of micelles prepared from a poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer
Poggi, Elio; Guerlain, Claire; Debuigne, Antoine ULg et al

in European Polymer Journal (2015), 62

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4 ... [more ▼]

A poly(vinyl alcohol)-block-poly(acrylic acid)-block-poly(4-vinylpyridine) triblock terpolymer (PVOH-b-PAA-b-P4VP) is prepared by hydrolyzing a poly(vinyl acetate)-block-poly(acrylonitrile)-block-poly(4-vinylpyridine) precursor (PVAc-b-PAN-b-P4VP) synthesized by a combination of cobalt-mediated radical polymerization (CMRP) and nitroxide mediated polymerization (NMP). The PVOH-b-PAA-b-P4VP terpolymer is further micellized in water and the accordingly obtained micellar structures are characterized by a combination of dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM) as a function of pH. Well-defined micelles are observed in the whole pH range except for pH values below 4.5 where non-aggregated chains (unimers) are present. The formation of micelles can be rationalized by the formation of insoluble PAA/P4VP inter-polyelectrolyte complexes in the 4.5–6 pH range while hydrophobic P4VP cores are observed at pH values above 6. Finally, the effect of the addition of different salts on the micellar characteristic features is investigated. [less ▲]

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See detail“Rhizoponics”: a novel hydroponic rhizotron for root system analyses on mature Arabidopsis thaliana plants
Mathieu, Laura ULg; Lobet, Guillaume ULg; Tocquin, Pierre ULg et al

in Plant Methods (2015), 11

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to ... [more ▼]

We present here an innovative design of hydroponic rhizotrons (rhizoponics) adapted to Arabidopsis thaliana. The setup allows to simultaneously characterize the RSA and shoot development from seedling to adult stages, i.e. from seed to seed. This system offers the advantages of hydroponics such as control of root environment and easy access to the roots for measurements or sampling. Being completely movable and low cost, it can be used in controlled cabinets. We chose the case of cadmium treatment to illustrate potential applications, from cell to organ levels. [less ▲]

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See detailIn situ bidentate to tetradentate ligand exchange reaction in cobalt-mediated radical polymerization
Kermagoret, Anthony ULg; Jérôme, Christine ULg; Detrembleur, Christophe ULg et al

in European Polymer Journal (2015), 62

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this ... [more ▼]

Organometallic-mediated radical polymerization (OMRP) has seen a significant growth in the last years notably due to the development of new metal complexes, especially cobalt derivatives. Despite of this, none of the reported complexes offers optimal control for monomers with very different reactivity, which somewhat limits the synthesis of copolymers. In order to expand the scope of cobalt-mediated radical polymerization (CMRP), we investigated an in situ ligand exchange reaction for modulating the properties of the cobalt complex at the polymer chain-end and adjusting the C-Co bond strength involved in the control process. With the aim of improving the synthesis of poly(vinyl acetate)-b-poly(n-butyl acrylate) copolymers, bidentate acetylacetonate ligands, which impart high level of control to the polymerization of vinyl acetate (VAc), were replaced in situ at the PVAc-cobalt chain-end by tetradentate Salen type ligands that are more suited to acrylates. [less ▲]

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See detailLes conditions de possibilité du dialogue philosophique. Synthèse d'une discussion menée au séminaire de Peyriac-Sur-Mer (juin 2014).
Herla, Anne ULg

in Diotime. Revue internationale de didactique de la philosophie. (2015), 63

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See detailRhoGTPases as Key players in mammalian cell adaptation to microgravity.
Louis, Fiona; Deroanne, Christophe ULg; Nusgens-Richelle, Betty ULg et al

in BioMed Research International (2015)

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See detailMultiscale modelling framework for the fracture of thin brittle polycrystalline films - Application to polysilicon
Mulay, Shantanu; Becker, Gauthier ULg; Vayrette, Renaud et al

in Computational Mechanics (2015), 55(1), 73-91

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability ... [more ▼]

Micro-electro-mechanical systems (MEMS) made of polycrystalline silicon are widely used in several engineering fields. The fracture properties of polycrystalline silicon directly affect their reliability. The effect of the orientation of grains on the fracture behaviour of polycrystalline silicon is investigated out of the several factors. This is achieved, firstly, by identifying the statistical variation of the fracture strength and critical strain energy release rate, at the nanoscopic scale, over a thin freestanding polycrystalline silicon film, having mesoscopic scale dimensions. The fracture stress and strain at the mesoscopic level are found to be closely matching with uniaxial tension experimental results. Secondly, the polycrystalline silicon film is considered at the continuum MEMS scale, and its fracture behaviour is studied by incorporating the nanoscopic scale effect of grain orientation. The entire modelling and simulation of the thin film is achieved by combining the discontinuous Galerkin method and extrinsic cohesive law describing the fracture process. [less ▲]

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See detailCompte-rendu de l'ouvrage d'Eva Illouz : "Hard Romance : "Cinquante nuances de Grey" et nous" (2014)
Ledent, David ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2015)

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See detailVascular calcification: from pathophysiology to biomarkers
EVRARD, Séverine ULg; DELANAYE, Pierre ULg; Kamel, S et al

in Clinica Chimica Acta (2015), 438

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have ... [more ▼]

The link between vascular calcification (VC) and increased mortality is now well established. Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlightedmore and more physiopathological mechanisms and signaling pathways that underlie VC. Several conditions such as diabetes, dyslipidemia and renal diseases are undoubtedly identified as predisposing factors. But even if the process is better understood,many questions still remain unanswered. This reviewbriefly develops the various theories that attempt to explain mineralization genesis. Nonetheless, the main purpose of the article is to provide a profile of the various existing biomarkers of VC. Indeed, in the past years, a lot of inhibitors and promoters, which form a dense and interconnected network, were identified. Given importance to assess and control mineralization process, a focusing on accumulated knowledge of each marker seemed to be necessary. Therefore, we tried to define their respective role in the physiopathology and how they can contribute to calcification risk assessment. Among these, Klotho/fibroblast growth factor-23, fetuin-A, Matrix Gla protein, Bone morphogenetic protein-2, osteoprotegerin, osteopontin, osteonectin, osteocalcin, pyrophosphate and sclerostin are specifically discussed. [less ▲]

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See detailMetabolic reprogramming in transformed mouse cortical astrocytes: a proteomic study.
Bentaib, Azeddine; De Tullio, Pascal ULg; Chneiweiss, Herve et al

in Journal of proteomics (2015), 113

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for ... [more ▼]

Metabolic reprogramming is thought to play a key role in sustaining the survival and proliferation of cancer cells. These changes facilitate for example the uptake and release of nutrients required for nucleotide, protein and lipid synthesis necessary for macromolecule assembly and tumor growth. We applied a 2D-DIGE (Two-Dimensional Differential in-Gel Electrophoresis) quantitative proteomic analysis to characterize the proteomes of mouse astrocytes that underwent in vitro cancerous transformation, and of their normal counterparts. Metabolic reprogramming effects on enzymatic and structural protein expression as well as associated metabolites abundance were quantified. Using enzymatic activity measurements and zymography, we documented and confirmed several changes in abundance and activity of various isoenzymes likely to participate in metabolic reprogramming. We found that after transformation, the cells increase their expression of glycolytic enzymes, thus augmenting their ability to use aerobic glycolysis (Warburg effect). An increased capacity to dispose of reducing equivalents through lactate production was also documented. Major effects on carbohydrates, amino acids and nucleotides metabolic enzymes were also observed. Conversely, the transformed cells reduced their enzymatic capacity for reactions of tricarboxylic acid oxidation, for neurotransmitter (glutamate) metabolism, for oxidative stress defense and their expression of astroglial markers. BIOLOGICAL SIGNIFICANCE: The use of a global approach based on a 2D DIGE analysis allows obtaining a comprehensive view of the metabolic reprogramming undergone by astrocytes upon cancerous transformation. Indeed, except for a few enzymes such as pyruvate carboxylase and glutaminase that were not detected in our initial analysis, pertinent information on the abundance of most enzymes belonging to pathways relevant to metabolic reprogramming was directly obtained. In this in vitro model, transformation causes major losses of astrocyte-specific proteins and functions and the acquisition of metabolic adaptations that favor intermediate metabolites production for increased macromolecule biosynthesis. Thus our approach appears to be readily applicable for the investigation of changes in protein abundance that determine various transformed cell phenotypes. It could similarly be applied to the evaluation of the effects of treatments aimed at correcting the consequences of cell transformation. [less ▲]

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See detailLa France et le Congo ex-belge (1961-1965). Intérêts et influences en mutation
Genin, Vincent ULg

in Revue Belge de Philologie et d'Histoire (2015), 91(2013/4), 1057-1110

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective ... [more ▼]

The history of decolonization is inseparable from that of Western interests in the newly independent states. The special case of Franco-Belgian Relations offers a rich and unexplored perspective. Ostracized by the United Nations in the summer of 1960 in the context of the Congolese crisis, Belgium has, however, been able to count on the support of France, itself immobilized by the Algerian case. Based on unpublished archives, it seems instructive to study the evolution of the Franco-Belgian relations, in terms of Central African Affairs from 1961 to 1965. France, the overseas influence policy is a fundamental factor, she will devote as much energy to develop and defend its interests in Congo former Belgian (on which she claimed in Brussels its preemptive right, dating back to 1884, spring 1960) as former territories of the French Community? What are the forms, the protagonists and channels (formal and informal) of this influence; how is she fits the postcolonial context and she has an impact on Franco-Belgian relations ? [less ▲]

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See detail18F-FDG PET Uptake Characterization Through Texture Analysis: Investigating the Complementary Nature of Heterogeneite and Functional Tumor Volume in a Multi-Cancer Site Patient Cohort
HATT, MAT; MAJDOUB, MOHAMED; VALLIERES, MARTIN et al

in Journal of Nuclear Medicine (The) (2015), 56(1), 38-44

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See detailThe Reputation Effect: A Case Study of Credit Contracts in Transition Countries
Artige, Lionel ULg; Nicolini, Rosella

in International Journal of Finance and Banking Studies (2015), 4(1), 1-17

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See detailEinleitung
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), -

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See detailInstitutional Investors, adverse selection and stock market liquidity in France
Sougné, Danielle ULg; Aymen, Ajina; Faten, Lakhal

in International Journal of Managerial Finance (2015), 11

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of ... [more ▼]

The purpose of this paper is to examine the effect of institutional investor's ownership and type on information asymmetry and stock market liquidity in France.The findings show that the proportion of institutional investors has a positive and significant effect on stock-market liquidity, which confirms the signal theory and trading hypothesis. These investors perform high trading activity which favorably affects market liquidity. The results also show that pension funds improve liquidity. This result suggests that pension funds manage huge assets decreasing transactions costs and improving liquidity. They display a positive signal to the market about more transparency and a low level of information asymmetry. [less ▲]

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See detailA simulation study comparing multiple imputation methods for incomplete longitudinal ordinal data
Donneau, Anne-Françoise ULg; Mauer, Murielle; Molenberghs, Geert et al

in Communications in Statistics : Simulation & Computation (2015), 44(5), 1311-1338

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See detailThree-Parameter Kinematic Theory for Shear Behavior of Continuous Deep Beams
Mihaylov, Boyan ULg; Hunt, Bradley; Bentz, Evan et al

in ACI Structural Journal (2015), 112(1), 47-57

This paper presents a theory for predicting shear strengths, deformations, and crack widths near failure of continuous deep beams. To describe the deformations in continuous deep beams, the theory uses a ... [more ▼]

This paper presents a theory for predicting shear strengths, deformations, and crack widths near failure of continuous deep beams. To describe the deformations in continuous deep beams, the theory uses a three-degree-of-freedom kinematic model (3PKT), which is an extension of an earlier two-degree-of-freedom model (2PKT) for members in single curvature. The extended model is validated with the help of measured local and global deformations taken during loading to failure of a large continuous deep beam. The accuracy of the shear-strength predictions given by the theory is evaluated using a database of 129 published tests of continuous deep beams. The theory enables the load distribution and failure loads of continuous deep beams subject to differential settlement to be evaluated. [less ▲]

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See detailSoft power, global governance of cultural industries and rising powers: the case of China
Vlassis, Antonios ULg

in International Journal of Cultural Policy (2015)

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to ... [more ▼]

This article addresses the importance of cultural industries for the strengthening of the soft power of the rising powers and it seeks to understand how the cultural industries allow rising powers to shape the structures of their international environment. More specifically, studying the cases of People’s Republic of China and of the movie industry, my article focuses on the current evolution of the relationship between the Chinese authorities and the film industry, as well as on the development of the domestic film market. I further aim to draw up an inventory of China’s role within the global governance of cultural industries. Finally, I aim to highlight the global cultural competition that China faces, emphasizing the practices of the US administration and Hollywood. I argue that even if China is the current centre of gravity within the world economy, it still has a long way to go in order to shape the distribution of resources within the global governance of cultural industries and to play a crucial role in the international battle of cultural symbols. [less ▲]

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See detailEpidemiological Review of Injuries in Rugby Union
Kaux, Jean-François ULg; Julia, Marc; Delvaux, François ULg et al

in Sports (2015), 3(1), 21-29

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This ... [more ▼]

Rugby is a sport that is growing in popularity. A contact sport par excellence, it causes a significant number of injuries. In Rugby Union, there are 30 to 91 injuries per 1000 match hours. This epidemiological review of injuries incurred by rugby players mentions the position and type of injuries, the causes, time during the match and season in which they occur and the players’ positions as well as the length of players’ absences following the injury. [less ▲]

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See detailN1-Fluoroalkyltryptophan analogues: synthesis and in vitro study as potential substrates for indoleamine 2,3-dioxygenase
Henrottin, Jean ULg; Zervosen, Astrid ULg; Lemaire, Christian ULg et al

in ACS Medicinal Chemistry Letters (2015)

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive ... [more ▼]

ABSTRACT: Indoleamine 2,3-dioxygenase (hIDO) is an enzyme that catalyzes the oxidative cleavage of the indole ring of L-tryptophan through the kynurenine pathway, thereby exerting immunosuppressive properties in inflammatory and tumoral tissues. The syntheses of 1-(2-fluoroethyl)-tryptophan (1-FETrp) and 1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-tryptophan, two N1-fluoroalkylated tryptophan derivatives, are described here. In vitro enzymatic assays with these two new potential substrates of hIDO show that 1-FETrp is a good and specific substrate of hIDO. Therefore, its radioactive isotopomer, 1-[18F]FETrp, should be a molecule of choice to visualize tumoral and inflammatory tissues and/or to validate new potential inhibitors. [less ▲]

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See detailPossibilities for Co(III) dissolution from an oxidized ore through simultaneous bioleaching of pyrite
Zeka, Leon; Lambert, Fanny ULg; Frenay, Jean ULg et al

in Minerals Engineering (2015)

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and ... [more ▼]

Solubilisation of Co(III) from a heterogenite met in copper cobaltiferous oxide ore has been realized through reductive leaching using ferrous iron generated via bio-oxidation of pyrite. Biotic and abiotic experiments at various pulp densities and redox potentials have been performed and results compared. Cobalt leaching at elevated redox potential is possible, offering cost reduction benefits due to reduced consumption of ferrous iron. At elevated potential of 625 mV, however, the initial rate of cobalt leaching has been found as 115 mg/(g ore)⋅(24 h), lower than the rate of 865 mg/(g ore)⋅(24 h) registered at 505 mV. Less stochiometric amount of ferrous iron was required when cobalt leaching was coupled to pyrite bioleaching, with 75% of cobalt recovered for 12 h at the optimally found conditions. It could be inferred that the Fe3+–Fe2+ cycle exists and is efficiently maintained through bacterial presence in the studied system. [less ▲]

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See detailConstruire des savoirs sur l'activité de lecture afin de développer les compétences des élèves en difficulté : l'inaccessible rêve?
De Croix, Séverine ULg; Ledur, Dominique

in Education & Formation (2015), e-302

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La ... [more ▼]

De nombreux jeunes adolescents faibles lecteurs se méprennent sur la nature de l’activité de lecture et souffrent d’un déficit métacognitif qui les empêche d’autoréguler leur activité de compréhension. La réflexion qui suit s’inscrit dans le cadre des travaux relatifs aux enseignements adaptés à la prise en charge de ces déficits. Des dispositifs visant à développer la métacognition en lecture, à construire des savoirs sur cette activité et à mieux se percevoir en tant que lecteur ont été conçus, expérimentés et analysés dans le cadre d’une recherche-action longitudinale de type qualitatif. Cet article décrit quelques effets de ces dispositifs, qui encouragent à poursuivre sur la voie de ces interventions à dimension métacognitive dans des recherches à plus large échelle. [less ▲]

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See detailDevelopment and validation of an accelerometer-based method for quantifying gait events
Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg; Stamatakis, Julien et al

in Medical Engineering & Physics (2015)

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO ... [more ▼]

An original signal processing algorithm is presented to automatically extract, on a stride-by-stride basis, four consecutive fundamental events of walking, heel strike (HS), toe strike (TS), heel-off (HO), and toe-off (TO), from wireless accelerometers applied to the right and left foot. First, the signals recorded from heel and toe three-axis accelerometers are segmented providing heel and toe flat phases. Then, the four gait events are defined from these flat phases. The accelerometer-based event identification was validated in seven healthy volunteers and a total of 247 trials against reference data provided by a force plate, a kinematic 3D analysis system, and video camera. HS, TS, HO, and TO were detected with a temporal accuracy ± precision of 1.3 ms ± 7.2 ms, ‒4.2 ms ± 10.9 ms, ‒3.7 ms ± 14.5 ms, and ‒1.8 ms ± 11.8 ms, respectively, with the associated 95% confidence intervals ranging from ‒6.3 ms to 2.2 ms. It is concluded that the developed accelerometer-based method can accurately and precisely detect HS, TS, HO, and TO, and could thus be used for the ambulatory monitoring of gait features computed from these events when measured concurrently in both feet. [less ▲]

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See detailStephen Jay Gould ou la science enchantée
Jacquemain, Marc ULg

in Politique : Revue de Débats (2015), 88

Stephen Jay Gould, inventeur de la "théorie des équilibres ponctués" avec Nils Elredge fut non seulement un paléontologue de premier plan mais aussi un défenseur acharné du darwinisme. Défenseur acharné ... [more ▼]

Stephen Jay Gould, inventeur de la "théorie des équilibres ponctués" avec Nils Elredge fut non seulement un paléontologue de premier plan mais aussi un défenseur acharné du darwinisme. Défenseur acharné, mais dénué de tout dogmatisme il s'est aussi battu pour une conception "humaniste" de la science, qui l'éloigne de tout scientisme et qui l'amène souvent à "réhabiliter les vaincus" de l'histoire des sciences. Enfin, s'il fut un défenseur de Darwin, il a combattu ceux de successeurs qui ont essayé de l'utiliser pour défendre l'inégalité sociale ou l'eugénisme. En cela Gould fut sans doute le meilleur des darwiniens. [less ▲]

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See detailImpact of the Structure of Biocompatible Aliphatic Polycarbonates on siRNA Transfection Ability
Frère, Antoine ULg; Kawalec, Michal; Tempelaar, Sarah et al

in Biomacromolecules (2015)

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or ... [more ▼]

RNAi therapeutics are promising therapeutic tools that have sparked the interest of many researchers. In an effort to provide a safe alternative to PEI, we have designed a series of new guanidinium and/or morpholino functionalized biocompatible and biodegradable polycarbonate vectors. The impact of different functions (morpholino-, guanidinium-, hydrophobic groups), of the architecture (linear homopolymer to dumbbell-shape) and of the molecular weight of these copolymers on their capacity to form polyplexes and to decrease the expression of two epigenetic regulators of gene expression, HDAC7 and HDAC5 was evaluated. The use of one of these polymers combining morpholine and guanidine functions at the ratio >1 and hydrophobic trimethylene carbonate groups showed a significant decrease of mRNA and protein level in HeLa cells, similar to PEI. These results highlight the potential of polycarbonate vectors for future in vivo application as an anti-cancer therapy. [less ▲]

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See detailMirabel: An integrated project for risk and cost/benefit analysis of peanut allergy
Crépet, A.; Papadopoulos, A.; Elegbede, C.F. et al

in Regulatory Toxicology & Pharmacology [=RTP] (2015), 71

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on ... [more ▼]

Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on exposure components such as the allergens present in foods and the consumption behaviour of allergic consumers and models to estimate the related risk need to be enriched. Mirabel proposes for the first time studying each risk component using an integrated approach in order to improve the quality of life of the allergic population. Field surveys were conducted in order to fill in the current gaps in unintentional allergen traces in food, allergic consumers’ food behaviour, threshold doses of allergic reaction, allergy symptoms and severity. The aim is also to propose methodological and operational tools to quantify allergic risk, to test management scenarios and to produce a cost/benefit analysis. Medical data on the peanut allergies of 785 patients were collected in the MIRABEL survey and 443 patients answered the food consumption questionnaire. The population surveyed was mostly paediatric – 86% were children under 16 years of age, with a high percentage of males (60%). This project will generate tangible results on peanut allergen exposure and risk which could be used in future risk assessment work and particularly to provide science-based guidance to set up concentration limits for peanut traces on packages. [less ▲]

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See detailNghiên cứu và thiết kế hai kiểu chuồng nuôi nhông cát Leiolepis guttata (Cuvier, 1829) phù hợp với điều kiện nuôi và vốn đầu tư tại huyện Bắc Bình, tỉnh Bình Thuận
Tran, Tinh ULg; Tran, Ngoc Nguyen Kim Dieu; Vo, Kim Thong et al

in Journal of Agriculture Sciences and Technology (2015), 1/2014

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan ... [more ▼]

Building of an enclosure for rearing of the spotted butterfly lizard, Leiolepis guttata (Cuvier, 1829), by the first farmer in 2004 (in Hong Chinh commune, Hoa Thang ward, Bac Binh district, Binh Thuan province) is considered as a fortuitous discovery which was the initiator of the current expanding trend of its rearing. Because L. guttata is a wild animal, with strong disease resistance and adaptation capacity, livestock farmers are presently not very interested in important aspects: rearing techniques, enclosure’s types, sex ratio, diseases’ prevention, etc. Notably the building of enclosures not perfectly suitable breeds a noticeable loss of the number of lizards and a reduction in the profits for the farmers. To this end, the building of two types of enclosures adapted to local rearing conditions and the investing capital available in Bac Binh district, Binh Thuan province is presently essential. We descrite two types of enclosure: the first one surrounded by a bricks (or breeze blocks) wall, the second one fended by a fiber cement corrugated sheets wall. Moreover, we suggest to introduce plants in order to build a vegetal cover nearer to the natural environment of L. guttata: shrubs and a plant carpet becoming the preferential refuge area of the spotted butterfly lizard. [less ▲]

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See detailEffect of stress path on the miniaturization size effect for nickel polycrystals
Keller, Clement; Hug, Eric; Habraken, Anne ULg et al

in International Journal of Plasticity (2015), 64

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a ... [more ▼]

The mechanical behavior of metallic materials deeply depends on the size of samples. For specimen dimensions decreasing from a few millimeters to a few micrometers, the general observed trend is a softening of the mechanical behavior in tension which affects the stress level and the strain hardening. The objective of this work is to provide new experimental results in order to analyze the miniaturization size effects for various stress paths without strain gradients across the thickness of the samples. To this aim, experimental tensile tests, large tensile tests and shear tests have been performed on Ni sheets with various grain sizes. Results show that the miniaturization softening is affected by triaxiality, the larger is this parameter, the lower is the mechanical softening. These features seem to be linked to surface effects which are larger for low triaxiality stress paths. From an industrial point of view, it is hence possible to improve the forming of microparts using suitable stress paths. [less ▲]

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See detailRéinventer le rythme / Den Rhythmus neu denken
Viehöver, Vera ULg; Dupont, Bruno

in Intervalles (2015), 7(2015), 170

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See detailEvolution de la chalarose du frêne en Wallonie
Gerarts, Fanny ULg; Chandelier, Anne; Claessens, Hugues ULg et al

in Forêt Wallonne (2015), 134

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See detailBiochemical characterisation of the seed oils of four safflower (Carthamus tinctorius) varieties grown in north-eastern of Morocco
Ben Moumen, Abdessamad; Mansouri, Farid; Richard, Gaetan ULg et al

in International Journal of Food Science & Technology (2015)

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi ... [more ▼]

The quality of the oil of four safflower varieties, originating from Spain (Rancho), India (Sharda) and Morocco (Cartamar and Cartafri), which were cultivated at the experimental station in Oujda (a semi-arid region of eastern Morocco) was evaluated through analysis of their phenolic and carotenoid contents. The composition of the phenolic compounds of safflower oil has not yet been documented. Therefore, in this preliminary study, Thirty different phenolic compounds were identified, and significant differences between the oil varieties were observed (P < 0.05). In the seed oil from the Rancho and Sharda safflower varieties, the main phenolic compound was trans-chalcone, representing 13.45% and 11.8%, respectively, of the total phenolics, whereas in Cartamar and Cartafri oils, naringin accounted for 26.82% and 16.5%, respectively, of the total phenolics. The total carotenoid contents ranged from 1.13 mg/kg (Rancho) to 1.34 mg/kg (Cartamar and Cartafri).We observed that b-cryptoxanthin (0.31–0.37 mg/kg) and b-carotene (0.3–0.35 mg/kg) were the predominant carotenoids in all of the safflower oils that were studied. [less ▲]

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See detailOptimal propellantless rendez-vous using differential drag
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Acta Astronautica (2015), 109

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us ... [more ▼]

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us to turn the often-undesired drag perturbation into a control force for relative motion, differential drag is among the most promising propellantless techniques for low-Earth orbiting satellites. An optimal control approach to the problem of orbital rendez-vous using differential drag is proposed in this paper. Thanks to the scheduling of a reference maneuver by means of a direct transcription, the method is flexible in terms of cost function and can easily account for constraints of various nature. Considerations on the practical realization of differential-drag-based maneuvers are also provided. The developments are illustrated by means of high-fidelity simulations including coupled 6-degree-of-freedom simulations and an advanced aerodynamic model. [less ▲]

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See detailA review of gliptins for 2014.
Scheen, André ULg

in Expert opinion on pharmacotherapy (2015), 16(1), 43-62

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a ... [more ▼]

Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place in the armamentarium of drugs used for the management of hyperglycaemia and offer new opportunities for a personalized medicine in patients with Type 2 diabetes. Areas covered: An updated review providing an analysis of available recent data with commercialized DPP-4 inhibitors, with a special focus on: differences between the various molecules, novelties regarding their mechanism of action, clinical efficacy in mono- and various combined therapies, comparison with other new therapies, efficacy-safety profile in at risk patients, concern about pancreatic safety, perspectives in cardiovascular prevention and, finally, a selection of remaining unanswered important questions for the clinician. Expert opinion: DPP-4 inhibitors offer various advantages when compared to other glucose-lowering agents. Despite they have been commercialized since a few years only, available data obtained in randomised controlled trials are of better quality compared to those available with ancient classical glucose-lowering agents, especially in more fragile populations such as elderly people, individuals with renal impairment or at high cardiovascular risk and patients at higher risk of hypoglycaemia. However, there remain uncertainties and controversies that should be resolved by further ongoing large prospective controlled trials and increasing clinical experience combined with a careful post-marketing surveillance. [less ▲]

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See detailOptimal propellantless rendez-vous using differential drag
Dell'Elce, Lamberto ULg; Kerschen, Gaëtan ULg

in Acta Astronautica (2015), 109

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us ... [more ▼]

Optimization of fuel consumption is a key driver in the design of spacecraft maneuvers. For this reason, growing interest in propellant-free maneuvers is observed in the literature. Because it allows us to turn the often-undesired drag perturbation into a control force for relative motion, differential drag is among the most promising propellantless techniques for low-Earth orbiting satellites. An optimal control approach to the problem of orbital rendez-vous using differential drag is proposed in this paper. Thanks to the scheduling of a reference maneuver by means of a direct transcription, the method is flexible in terms of cost function and can easily account for constraints of various nature. Considerations on the practical realization of differential-drag-based maneuvers are also provided. The developments are illustrated by means of high-fidelity simulations including coupled 6-degree-of-freedom simulations and an advanced aerodynamic model. [less ▲]

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See detailChine, une mise à jour
Florence, Eric ULg

in Politique : Revue de Débats (2015), 88

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois ... [more ▼]

Au lendemain de la répression du mouvement démocratique de 1989, journalistes, analystes et autres « China watchers » abondaient en commentaires crépusculaires sur la pérennité du régime chinois. L’argument le plus souvent évoqué était celui d’un décalage insoutenable entre réformes économiques – qui connaîtront un approfondissement à l’occasion du fameux « voyage dans le Sud » de Deng Xiaoping en 1992 – et l’absence de réformes politiques, un décalage qui devait presque immanquablement signifier la fin du régime communiste. Quelque vingt-cinq ans plus tard, où en est-on ? [less ▲]

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See detailReview of Transnational Migration
Munos, Delphine ULg

in South Asian Diaspora (2015), 7(1), 63-65

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See detailProbiotics: an update
Vandenplas, Yvan; Huys, Geert; Daube, Georges ULg

in Jornal de Pediatria (2015), 1

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent ... [more ▼]

Objective: Triggered by the growing knowledge on the link between the intestinal microbiome and human health, the interest in probiotics is ever increasing. The authors aimed to review the recent literature on probiotics, from definitions to clinical benefits, with emphasis on children. Sources: Relevant literature from searches of PubMed, CINAHL, and recent consensus statements were reviewed. Summary of the findings: While a balanced microbiome is related to health, an imbalanced microbiome or dysbiosis is related to many health problems both within the gastro-intestinal tract, such as diarrhea and inflammatory bowel disease, and outside the gastro-intestinal tract such as obesity and allergy. In this context, a strict regulation of probiotics with health claims is urgent, because the vast majority of these products are commercialized as food (supplements), claiming health benefits that are often not substantiated with clinically relevant evidence. The major indications of probiotics are in the area of the prevention and treatment of gastrointestinal related disorders, but more data has become available on extra-intestinal indications. At least two published randomized controlled trials with the commercialized probiotic product in the claimed indication are a minimal condition before a claim can be sustained. Today, Lactobacillus rhamnosus GG and Saccharomyces boulardii are the best-studied strains. Although adverse effects have sporadically been reported, these probiotics can be considered as safe. Conclusions: Although regulation is improving, more stringent definitions are still required. Evidence of clinical benefit is accumulating, although still missing in many areas. Misuse and use of products that have not been validated constitute potential drawbacks. [less ▲]

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See detail"Lire le rythme". Heri Meschonnics Theorie und Praxis des Lesens
Viehöver, Vera ULg

in Intervalles (2015), 7(2015), 41-60

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See detailModelled target attainment after meropenem infusion in patients with severe nosocomial pneumonia: the PROMESSE study.
FRIPPIAT, Frédéric ULg; Musuamba, FT; Seidel, Laurence ULg et al

in Journal of Antimicrobial Chemotherapy (2015)

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in ... [more ▼]

OBJECTIVES: The objective of this study was to propose an optimal treatment regimen of meropenem in critically ill patients with severe nosocomial pneumonia. PATIENTS AND METHODS: Among 55 patients in intensive care treated with 1 g of meropenem every 8 h for severe nosocomial pneumonia, 30 were assigned to intermittent infusion (II; over 0.5 h) and 25 to extended infusion (EI; over 3 h) groups. Based on plasma and epithelial lining fluid (ELF) concentrations determined at steady-state, pharmacokinetic modelling and Monte Carlo simulations were undertaken to assess the probability of attaining drug concentrations above the MIC for 40%-100% of the time between doses (%T > 1-fold and 4-fold MIC), for 1 or 2 g administered by either method. RESULTS: Penetration ratio, measured by the ELF/plasma ratio of AUCs, was statistically higher in the EI group than in the II group (mean ± SEM: 0.29 ± 0.030 versus 0.20 ± 0.033, P = 0.047). Considering a maximum susceptibility breakpoint of 2 mg/L, all dosages and modes of infusions achieved 40%-100% T > 1-fold MIC in plasma, but none did so in ELF, and only the 2 g dose over EI achieved 40%-100% T > 4-fold MIC in plasma. CONCLUSIONS: The optimum regimen to treat severe nosocomial pneumonia was 2 g of meropenem infused over 3 h every 8 h. This regimen achieved the highest pharmacodynamic targets both in plasma and in ELF. [less ▲]

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See detailPurification and identification of novel antioxidant peptides from enzymatic hydrolysate of chickpea (Cicer arietinum L.) protein concentrate
Ghribi, Abir Mokni; Sila, Assaâd; Przybylski, Rémi et al

in Journal of functional foods (2015), 12

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher ... [more ▼]

Enzymatic hydrolysis of chickpea protein concentrate (CP) by Alcalase® and some physiochemical and antioxidant properties of the resulting hydrolysate (CPH) were characterised. CPH displayed higher antioxidant activity than CP. This hydrolysate was fractionated by size exclusion chromatography on a Sephadex G-25 into four major fractions (Fra.I, Fra.II, Fra.III, and Fra.IV). Fraction III, which exhibited the highest DPPH scavenging activity (54% at 1 mg/ml), was then fractionated by reversed-phase high performance liquid chromatography (RP-HPLC). Eleven antioxidant fractions were isolated and two peptide subfractions show antioxidant activity (P3 and P8). The P8 displayed the highest DPPH radicalscavenging activity (67%; at 200 g/ml) among these peptides subfractions. The molecular masses and amino acids sequences of the purified peptides were determined using ESIMS and ESIMS/MS, respectively. Their structures were identified as Asp-His-Gly and Val- Gly-Asp-Ile. These peptides did not show haemolytic activity towards bovine erythrocytes. The results suggest that CPH are good source of natural antioxidants. [less ▲]

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See detailThe impact of transport policies on railroad intermodal freight competitiveness – The case of Belgium
Santos, Bruno F.; Limbourg, Sabine ULg; Carreira, Joana Silva

in Transportation Research. Part D : Transport and Environment (2015), 34

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist ... [more ▼]

This paper discusses the impact of three freight transport policies aiming to promote railroad intermodal transport in Europe, and examines the case of Belgium as a testing ground. These policies consist in subsidizing intermodal transport operations (such as in Belgium, to stimulate rail transport), internalizing external costs (as recommended by the European Union in order to foster cleaner modes), and adopting a system perspective when optimizing the location of inland intermodal terminals. The study proposes an innovative mixed integer intermodal freight location-allocation model based on hub-location theory and deals with non-linear transport costs in order to replicate economies of distance. Our analysis suggests that subsidizing has a significant impact on the volumes transported by intermodal transport, and, to a lesser extent, that optimizing terminal location increases the competitiveness of intermodal transport. On the other hand, according to our assumptions, internalizing external costs can negatively impact the promotion of intermodality. This finding indicates that innovative last-mile transports are needed in order to reduce the external impacts of drayage operations. [less ▲]

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See detailUse of wheat bran arabinoxylans in chitosan-based films: Effect on physicochemical properties
Costa, Maria J.; Cerqueira, Miguel A.; Ruiz, Héctor A. et al

in Industrial Crops and Products (2015), 66

tThe aim of this work was to evaluate physicochemical properties of chitosan-based films with differentfractions of arabinoxylans (AXs). Five fractions composed by AXs or mixtures of AXs and arabino-xylo ... [more ▼]

tThe aim of this work was to evaluate physicochemical properties of chitosan-based films with differentfractions of arabinoxylans (AXs). Five fractions composed by AXs or mixtures of AXs and arabino-xylo-oligosaccharides (AXOS) obtained through three different processes were added to chitosan-based films.These films were obtained by solvent casting and characterized in terms of water vapor permeability(WVP), opacity, thickness, moisture content and mechanical properties (i.e., tensile strength – TS andelongation at break – EB), being the chemical interactions evaluated by FTIR.Moisture content values ranged between 20 and 30% for all five studied films being the lowest valueobserved for chitosan films with the fraction F1 of AX/AXOS (21.1%). The films with incorporation of F3a,F3b and F4 AXs fraction were more opaque (>10%) than the other studied films. Regarding mechanicalproperties CH films presented EB and TS values of 31.26% and 8.25 MPa, respectively, both these valuesremain statistically equal with the incorporation of AX/AXOS except for films containing the fractionF1 and F2. For films with the F2 fraction were obtained higher values of EB (41.31%) while for CH filmscontaining the F1 fraction the TS values (13.07 MPa) increased.In conclusion, wheat bran AXs can be successfully incorporated into chitosan-based edible films pro-viding, together with chitosan, an extra functional value to films, due their health benefits. [less ▲]

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See detailAgeism and its clinical impact in oncogeriatry: state of knowledge and therapeutic leads
Schroyen, Sarah ULg; Adam, Stéphane ULg; JERUSALEM, Guy ULg et al

in Clinical Interventions in Aging (2015), 10

Cancer is a major health problem that is widespread in elderly people. Paradoxically, older people suffering from cancer are often excluded from clinical trials and are undertreated when compared to ... [more ▼]

Cancer is a major health problem that is widespread in elderly people. Paradoxically, older people suffering from cancer are often excluded from clinical trials and are undertreated when compared to younger patients. One explanation for these observations is age stigma (ie, stereotypes linked to age, and thus ageism). These stigmas can result in deleterious consequences for elderly people’s mental and physical health in “normal” aging. What, then, is the impact in a pathological context, such as oncology? Moreover, health care professionals’ attitudes can be tainted with ageism, thus leading to undesirable consequences for patients. To counter these stigmas, we can apply some possible interventions emerging from research on normal aging and from social psychology, such as intergenerational contact, activation of positive stereotypes, self-affirmation, and so on; these tools can improve opinions of aging among the elderly people themselves, as well as health care professionals, thus affecting patients’ mental and physical health. [less ▲]

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See detailIncentive salience attribution under reward uncertainty: A Pavlovian model
Anselme, Patrick ULg

in Behavioural Processes (2015), 111(1), 6-18

There is a vast literature on the behavioural effects of partial reinforcement in Pavlovian conditioning. Compared with animals receiving continuous reinforcement, partially rewarded animals typically ... [more ▼]

There is a vast literature on the behavioural effects of partial reinforcement in Pavlovian conditioning. Compared with animals receiving continuous reinforcement, partially rewarded animals typically show (a) a slower development of the conditioned response (CR) early in training and (b) a higher asymptotic level of the CR later in training. This phenomenon is known as the partial reinforcement acquisition effect (PRAE). Learning models of Pavlovian conditioning fail to account for it. In accordance with the incentive salience hypothesis, it is here argued that incentive motivation (or ‘wanting’) plays a more direct role in controlling behaviour than does learning, and reward uncertainty is shown to have an excitatory effect on incentive motivation. The psychological origin of that effect is discussed and a computational model integrating this new interpretation is developed. Many features of CRs under partial reinforcement emerge from this model. [less ▲]

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See detailResponse of plant functional traits during the restoration of calcareous grasslands from forest stands
Piqueray, Julien; Ferroni, Lucia; Delescaille, Louis-Marie et al

in Ecological Indicators (2015)

In this survey, we studied the response of plant functional traits to calcareous grassland restoration in the Calestienne region, Southern Belgium (restoration protocol: forest clear-cutting followed by ... [more ▼]

In this survey, we studied the response of plant functional traits to calcareous grassland restoration in the Calestienne region, Southern Belgium (restoration protocol: forest clear-cutting followed by grazing at all sites). We considered traits related to dispersal, establishment, and persistence that integrate the main challenges of plants to re-establish and survive in restored areas. Functional traits were compiled from databases and compared among (i) pre-restoration and young restoration forests; (ii) restoration areas of different ages; and (iii) old restorations and reference grasslands. The following questions were addressed: (i) What is the early response (2-4 years) in terms of plant functional trait following one restorative clear-cut event? (ii) What plants functional trait responses occur from restorative management (i.e. sheep and goat grazing)? (iii) Which differences still persist between the oldest restored parcels (10-15 years), and the historical reference grasslands? Forest clear-cuts induced several changes among functional traits, including decreased mean seed mass and certain vegetative traits (i.e. decreased phanerophytes, branching species; and increased short lifespan species i.e. annuals and biennials). During restorative management, clonal, epizoochorous and autumn germinating species were favored. Despite numerous other changes during this phase, many differences remained compared to reference grasslands. In particular, geophytes, mycorrhizal and evergreen species abundance were not approaching reference grassland values. The observed pattern helped to draw inferences on the possible mechanisms operating under vegetation recovery following restorative forest clear-cut and subsequent management were identified and described in this study. Results indicated grazing was an important factor, which increased epizoochorous species, and autumn germinating taxa that filled niches in vegetation opened by summer grazing animals. Finally, differences between old restoration and reference grasslands emphasized that management should focus on reduction in soil fertility, and geophyte rhizomatous grasses. Long-term monitoring is vital to assess if management plans are effective in the complete restoration of species functional trait assemblages. [less ▲]

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See detailGiven to a Deity? Religious and Social Reappraisal of Human Consecrations in the Hellenistic and Roman East
Caneva, Stefano ULg; Delli Pizzi, Aurian ULg

in Classical Quarterly (2015), 65(1), 167-191

Various cases of human beings ‘dedicated’ to deities are attested in Greek epigraphic evidence. Are these kinds of offerings comparable to the dedication of inanimate objects? Besides, does the fact that ... [more ▼]

Various cases of human beings ‘dedicated’ to deities are attested in Greek epigraphic evidence. Are these kinds of offerings comparable to the dedication of inanimate objects? Besides, does the fact that someone is said to be ‘sacred’ to a specific deity necessarily involve that he went through a process of dedication? This article aims at providing a global picture of different situations in which processes of dedications took place. Among the several issues that are tackled, the cornerstone of this article consists of two questions: for what purposes did some people decide to consecrate a human being to a deity and what were the consequences for the consecrated individuals on religious and social levels? Different categories of persons will be contrasted, in terms of processes through which they acquire their new status but also in terms of the freedom/lack of freedom which is conveyed by this new status. It will also be shown that, as far as method is concerned, it is necessary to complete a lexical analysis with a contextual perspective for a deeper understanding of the problem. [less ▲]

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See detailSolar Energy Prediction: An International Contest to Initiate Interdisciplinary Research on Compelling Meteorological Problems
McGovern, Amy; Gagne II, David John; Eustaquio, Lucas et al

in Bulletin of the American Meteorological Society [= BAMS] (2015)

As meteorological observing systems and models grow in complexity and number, the size of the data becomes overwhelming for humans to analyze using traditional techniques. Computer scientists, and ... [more ▼]

As meteorological observing systems and models grow in complexity and number, the size of the data becomes overwhelming for humans to analyze using traditional techniques. Computer scientists, and specifically machine learning and data mining researchers, are developing frameworks for analyzing big data. The AMS Committee on Artificial Intelligence and its Applications to Environmental Science aims to bring AI researchers and environmental scientists together to increase the synergy between the two. The AI committee has sponsored 4 previous contests on a variety of meteorological problems including wind energy, storm classification, winter hydrometeor classification, and air pollution, with the goal of bringing together the two fields of research. Although these were successful, the audience was limited to existing environmental science researchers (usually 10-20 teams of people primarily within the AMS community). For the 2013/14 contest, we expanded to a global audience by focusing on the compelling problem of solar energy prediction and by having the established forum Kaggle host our contest. Using this forum, we had over 160 teams from all around the world participate. Improved solar energy forecasting is a necessary component of making solar energy a viable alternative power source. This paper summarizes our experiences in the 2013/14 contest, discusses the data in detail, and presents the winning prediction methods. The contest data come from the NOAA/ESRL Global Ensemble Forecasting System Reforecast Version 2 and the Oklahoma Mesonet with sponsorship from EarthRisk Technologies. All winning methods utilized gradient boosted regression trees but differed in parameter choices and interpolation methods. [less ▲]

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See detailFunctional adaptations of the bacterial chaperone trigger factor to extreme environmental temperatures
Godin-Roulling, Amandine ULg; Schmidpeter, P.A.M.; Schmid, F.X. et al

in Environmental Microbiology (2015)

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See detailDes chiffres de la politique à la politique du chiffre Le cas des réformes du financement de la recherche dans les universités belge francophones.
Fallon, Catherine ULg

in Reflets et Perspectives de la Vie Economique (2015)

“Governing by numbers” is a trend on the increase in public action. Numbers tend to pervade the politico-administrative space without questioning neither the quantification processes which produce them ... [more ▼]

“Governing by numbers” is a trend on the increase in public action. Numbers tend to pervade the politico-administrative space without questioning neither the quantification processes which produce them nor the conditions of their utilization in government. And yet the use of numbers and data in political arguments contribute to transform the terms of the debate: politics can transform data and indicators, but one should not neglect how numbers affect policymaking. This article proposes as case study the analysis of some recent transformations of public research funding mechanism in universities in French speaking Belgium. It questions the systemic effects of the use of performance indicators in public management in this sector and it proposes some starting points for a discussion of their impact on the quality of the political debate. [less ▲]

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See detailOptimal control of a Cope rearrangement by coupling the reaction path to a dissipative bath or a second active mode
Chenel, Aurélie; Meier, Christoph; Dive, Georges et al

in The Journal of Chimical Physics (2015), 142

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See detailMaternal transfer of organohalogenated compounds in sharks and stingrays
Weijs, Liesbeth; Briels, Nathalie; Adams, Douglas et al

in Marine Pollution Bulletin (2015)

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study ... [more ▼]

Elasmobranchs can bioaccumulate considerable amounts of persistent organic pollutants (POPs) and utilize several reproductive strategies thereby influencing maternal transfer of contaminants. This study provides preliminary data on the POP transfer from pregnant females to offspring of three species (Atlantic stingrays, bonnethead, blacktip sharks) with different reproduction modes (aplacental, placental viviparity). Polychlorinated biphenyl (PCB) levels were generally higher than any other POPs. Stingrays and blacktip shark embryos contained the lowest POP concentrations while bonnetheads and the blacktip adult female had the highest concentrations. Results suggest that are more readily transferred from the mother to the embryo compared to what is transferred to ova in stingrays. Statistically significant differences in levels of selected POPs were found between embryos from the left and right uterus within the same litter as well as between female and male embryos within the same litter for bonnetheads, but not for the blacktip sharks. [less ▲]

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See detailUsing zero-inlated models to predict the relative distribution and abundance of roe deer over very large spatial scales
Bouyer, Yaëlle ULg; Rigot, Thibaud; Panzacchi, Manuela et al

in Annales Zoologici Fennici (2015), 52

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution ... [more ▼]

In Norway, recovering populations of large carnivores commonly prey on roe deer (Capreolus capreolus). Understanding predator habitat use and ecology requires fine-scaled information on prey distribution and abundance. However, the massive spatial scales at which large carnivores use the landscape presents many practical and statistical challenges for developing functional prey distribution models. Pellet-count data from >1000 km of transects gathered across southeastern Norway from 2005 to 2011 were used to derive a map of relative prey abundance for roe deer. These data were modeled using zero-inflated hurdle models using both environmental and anthropogenic variables. Snow depth and agricultural fields were the most significant variables in explaining both presence and abundance. Internal k-cross validation of the model showed medium accuracy (Spearman r = 0.35), whereas external evaluation carried out on the basis of independently collected snow-tracking data (Spearman r = 0.37) and hunting statistics (Spearman r = 0.88) showed high accuracy. The map generated can facilitate both the study of broad scale processes linking predators and prey as well as roe deer management in southeastern Norway. [less ▲]

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See detailDesign of Pt/carbon xerogel catalysts for PEM fuel cells
Job, Nathalie ULg; Lambert, Stéphanie ULg; Zubiaur, Anthony ULg et al

in Catalysts (2015), 5

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See detailA note on the equivalence between observed and expected information functions with polytomous IRT models
Magis, David ULg

in Journal of Educational & Behavioral Statistics (2015), 40

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected ... [more ▼]

The purpose of this note is to study the equivalence of observed and expected (Fisher) information functions with polytomous item response theory (IRT) models. It is established that observed and expected information functions are equivalent for the class of divide-by-total models (including partial credit, generalized partial credit, rating scale and nominal response models), but not for the class of difference models (including the graded response and modified graded response models). Yet, observed information function remains positive in both classes. Straightforward connections with dichotomous IRT models and further implications are outlined. [less ▲]

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See detailClimate Change and Tritrophic Interactions: Will Modifications to Greenhouse Gas Emissions Increase the Vulnerability of Herbivorous Insects to Natural Enemies?
Boullis, Antoine ULg; Francis, Frédéric ULg; Verheggen, François ULg

in Environmental Entomology (2015)

Insects are highly dependent on odor cues released into the environment to locate conspecifics or food sources. This mechanism is particularly important for insect predators that rely on kairomones ... [more ▼]

Insects are highly dependent on odor cues released into the environment to locate conspecifics or food sources. This mechanism is particularly important for insect predators that rely on kairomones released by their prey to detect them. In the context of climate change and, more specifically, modifications in the gas composition of the atmosphere, chemical communication-mediating interactions between phytophagous insect pests, their host plants, and their natural enemies is likely to be impacted. Several reports have indicated that modifications to plants caused by elevated carbon dioxide and ozone concentrations might indirectly affect insect herbivores, with community-level modifications to this group potentially having an indirect influence on higher trophic levels. The vulnerability of agricultural insect pests toward their natural enemies under elevated greenhouse gases concentrations has been frequently reported, but conflicting results have been obtained. This literature review shows that the higher levels of carbon dioxide, as predicted for the coming century, do not enhance the abundance or efficiency of natural enemies to locate hosts or prey in most published studies. Increased ozone levels lead to modifications in herbivore-induced volatile organic compounds (VOCs) released by damaged plants, which may impact the attractiveness of these herbivores to the third trophic level. Furthermore, other oxidative gases (such as SO2 and NO2) tend to reduce the abundance of natural enemies. The impact of changes in atmospheric gas emissions on plant–insect and insect–insect chemical communication has been under-documented, despite the significance of these mechanisms in tritrophic interactions. We conclude by suggesting some further prospects on this topic of research yet to be investigated. [less ▲]

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See detailMetal bioavailability and bioaccumulation in the polychaete Nereis virens (Sars): the effects of site-specific sediment characteristics
Pini, Jennifer; Richir, Jonathan ULg; Watson, Gordon

in Marine Pollution Bulletin (2015), accepted for publication

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis virens, as well as the ... [more ▼]

The present study investigates the relationships between copper (Cu) and zinc (Zn) concentrations in sediment, pore water and their bioaccumulation in the polychaete Nereis virens, as well as the importance of site-specific sediment characteristics in that process. Sediment, pore water and N. virens were sampled from seven sites with different pollution histories along the English Channel coast. Results showed that site-specific metal levels and sediment characteristics were important in determining the bioavailability of metals to worms. Significant correlations were found between Cu in the sediment and in the pore water and between Zn in the pore water and in N. virens. Zn from the pore water was thus more readily available from a dissolved source to N. virens than Cu. Data also showed that metal concentrations in N. virens were lower than those found in other closely related polychaetes, indicating that it may regulate tissue concentrations of Cu and Zn. [less ▲]

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