Advanced search

Browse ORBi by ORBi project The Open Access movement
ORBi is a project of

 References of "Scientific journals"      in Complete repository Arts & humanities   Archaeology   Art & art history   Classical & oriental studies   History   Languages & linguistics   Literature   Performing arts   Philosophy & ethics   Religion & theology   Multidisciplinary, general & others Business & economic sciences   Accounting & auditing   Production, distribution & supply chain management   Finance   General management & organizational theory   Human resources management   Management information systems   Marketing   Strategy & innovation   Quantitative methods in economics & management   General economics & history of economic thought   International economics   Macroeconomics & monetary economics   Microeconomics   Economic systems & public economics   Social economics   Special economic topics (health, labor, transportation…)   Multidisciplinary, general & others Engineering, computing & technology   Aerospace & aeronautics engineering   Architecture   Chemical engineering   Civil engineering   Computer science   Electrical & electronics engineering   Energy   Geological, petroleum & mining engineering   Materials science & engineering   Mechanical engineering   Multidisciplinary, general & others Human health sciences   Alternative medicine   Anesthesia & intensive care   Cardiovascular & respiratory systems   Dentistry & oral medicine   Dermatology   Endocrinology, metabolism & nutrition   Forensic medicine   Gastroenterology & hepatology   General & internal medicine   Geriatrics   Hematology   Immunology & infectious disease   Laboratory medicine & medical technology   Neurology   Oncology   Ophthalmology   Orthopedics, rehabilitation & sports medicine   Otolaryngology   Pediatrics   Pharmacy, pharmacology & toxicology   Psychiatry   Public health, health care sciences & services   Radiology, nuclear medicine & imaging   Reproductive medicine (gynecology, andrology, obstetrics)   Rheumatology   Surgery   Urology & nephrology   Multidisciplinary, general & others Law, criminology & political science   Civil law   Criminal law & procedure   Criminology   Economic & commercial law   European & international law   Judicial law   Metalaw, Roman law, history of law & comparative law   Political science, public administration & international relations   Public law   Social law   Tax law   Multidisciplinary, general & others Life sciences   Agriculture & agronomy   Anatomy (cytology, histology, embryology...) & physiology   Animal production & animal husbandry   Aquatic sciences & oceanology   Biochemistry, biophysics & molecular biology   Biotechnology   Entomology & pest control   Environmental sciences & ecology   Food science   Genetics & genetic processes   Microbiology   Phytobiology (plant sciences, forestry, mycology...)   Veterinary medicine & animal health   Zoology   Multidisciplinary, general & others Physical, chemical, mathematical & earth Sciences   Chemistry   Earth sciences & physical geography   Mathematics   Physics   Space science, astronomy & astrophysics   Multidisciplinary, general & others Social & behavioral sciences, psychology   Animal psychology, ethology & psychobiology   Anthropology   Communication & mass media   Education & instruction   Human geography & demography   Library & information sciences   Neurosciences & behavior   Regional & inter-regional studies   Social work & social policy   Sociology & social sciences   Social, industrial & organizational psychology   Theoretical & cognitive psychology   Treatment & clinical psychology   Multidisciplinary, general & others     Showing results 401 to 500 of 59920     1 2 3 4 5 6 7 8 9 10     D. W. Vasaco and A. Datta-Gupta: Subsurface Fluid Flow and Imaging—With Applications for Hydrology, Reservoir Engineering and GeophysicsDassargues, Alain in Mathematical Geosciences (2017)Book reviewDetailed reference viewed: 28 (2 ULg) Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesisRosewick, Nicolas; Durkin, Keith ; Artesi, Maria et alin Nature Communications (2017), 8Detailed reference viewed: 30 (4 ULg) Controlled synthesis of fluorinated copolymers via cobalt-mediated radical copolymerization of perfluorohexylethylene and vinyl acetateDemarteau, Jérémy ; Améduri, Bruno; Ladmiral, Vincent et alin Macromolecules (2017), 50(10), 3750-3760Designing novel polyfluoropolymer architectures is attractive for the development of new applications, such as advanced coatings, purification membranes, or materials for energy. Nevertheless, controlling ... [more ▼]Designing novel polyfluoropolymer architectures is attractive for the development of new applications, such as advanced coatings, purification membranes, or materials for energy. Nevertheless, controlling the radical polymerization of fluoroalkenes is very challenging due to the high reactivity of the propagating fluorinated macroradicals. This study aims at exploring the controlled copolymerization of perfluoro- hexylethylene (PFHE) and vinyl acetate (VAc) in order to prepare a range of well-defined statistical poly(PFHE-stat-VAc) copolymers with different compositions. Cobalt-mediated radical polymerization demonstrated to be active at 40 °C starting from an alkylcobalt(III) initiator, and copolymers with a fluorinated monomer content as high as ca. 80 wt % were successfully prepared. Reactivity ratios were determined to be rVAc = 0.18 and rPFHE = 0 at 40 °C and emphasized a clear tendency for alternation. Unprecedented PFHE/VAc containing block copolymers were also prepared via a single-step approach or through sequential copolymerizations. Finally, hydrolysis of the pendant ester groups of these copolymers led to the corresponding fluorinated copolymers bearing vinyl alcohol (VOH). A preliminary solution behavior study, carried out by dynamic light scattering and transmission electron microscopy on block copolymers composed of PFHE and VAc or VOH units, evidenced a marked amphiphilicity of the copolymer composed of an extremely hydrophobic PFHE block associated with a highly hydrophilic PVOH segment. [less ▲]Detailed reference viewed: 28 (6 ULg) Effects of preference and sensory modality on behavioral reaction in patients with disorders of consciousnessHeine, Lizette ; Tillmann, Barbara; Hauet, Marjolaine et alin Brain Injury (2017)Background: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of ... [more ▼]Background: Reliable evaluation of patients with unresponsive wakefulness syndrome (UWS) or in a minimally conscious state (MCS) remains a major challenge. It has been suggested that the expression of residual cerebral function could be improved by allowing patients to listen to their favourite music. However, the potential effect of music on behavioural responsiveness, as well as the effect of preferred stimuli in other sensory modalities (e.g. olfaction), remain poorly understood. Objective: The aim of our study was to investigate the effect of sensory modality (auditory versus olfactory) and preference (preferred versus neutral) of the test stimuli on patients’ subsequent performance on the Coma Recovery Scale-Revised (CRS-R). Research design: Within-subject design because of inter-individual differences between patients. Methods and procedures: We studied four items from the CRS-R (visual pursuit using a mirror, auditory localization of the own name and two movements to command) in 13 patients (7 MCS; 6 UWS). Main outcomes and results: Auditory stimuli triggered higher responsiveness compared to olfactory stimuli, and preferred stimuli were followed by higher scores than did neutral stimuli. Conclusions: Findings suggest that preferred auditory stimuli at the bedside contribute to the expression of residual function and could improve the diagnostic assessment. [less ▲]Detailed reference viewed: 21 (5 ULg) Puzzling Out Synaptic Vesicle 2 Family Members FunctionsBartholomé, Odile ; Van Den Ackerveken, Priscilla ; Sanchez Gil, Judit et alin Frontiers in Molecular Neuroscience (2017)Detailed reference viewed: 3 (1 ULg) Healing Effect of Controlled Anti-Electromigration on Conventional and High-Tc Superconducting NanowiresBaumans, Xavier ; Lombardo, Joseph ; Brisbois, Jérémy et alin Small : Nano Micro (2017), 1700384The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ... [more ▼]The electromigration process has the potential capability to move atoms one by one when properly controlled. It is therefore an appealing tool to tune the cross section of monoatomic compounds with ultimate resolution or, in the case of polyatomic compounds, to change the stoichiometry with the same atomic precision. As demonstrated here, a combination of electromigration and anti-electromigration can be used to reversibly displace atoms with a high degree of control. This enables a fine adjustment of the superconducting properties of Al weak links, whereas in Nb the diffusion of atoms leads to a more irreversible process. In a superconductor with a complex unit cell (La 2−x Ce x CuO 4 ), the electromigration process acts selectively on the oxygen atoms with no apparent modification of the structure. This allows to adjust the doping of this compound and switch from a superconducting to an insulating state in a nearly reversible fashion. In addition, the conditions needed to replace feedback controlled electromigration by a simpler technique of electropulsing are discussed. These findings have a direct practical application as a method to explore the dependence of the characteristic parameters on the exact oxygen content and pave the way for a reversible control of local properties of nanowires. [less ▲]Detailed reference viewed: 13 (8 ULg) The prevention of fragility fractures in patients with non-metastatic prostate cancer: a position statement by the international osteoporosis foundation.CIANFEROTTI, L; BERTOLDO, F; CARINI, M et alin Oncotarget (2017)Androgen deprivation therapy is commonly employed for the treatment of nonmetastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer ... [more ▼]Androgen deprivation therapy is commonly employed for the treatment of nonmetastatic prostate cancer as primary or adjuvant treatment. The skeleton is greatly compromised in men with prostate cancer during androgen deprivation therapy because of the lack of androgens and estrogens, which are trophic factors for bone. Men receiving androgen deprivation therapy sustain variable degrees of bone loss with an increased risk of fragility fractures. Several bone antiresorptive agents have been tested in randomized controlled trials in these patients. Oral bisphosphonates, such as alendronate and risedronate, and intravenous bisphosphonates, such as pamidronate and zoledronic acid, have been shown to increase bone density and decrease the risk of fractures in men receiving androgen deprivation therapy. Denosumab, a fully monoclonal antibody that inhibits osteoclastic-mediated bone resorption, is also effective in increasing bone mineral density and reducing fracture rates in these patients. The assessment of fracture risk, T-score and/or the evaluation of prévalent fragility fractures are mandatory for the selection of patients who will benefit from antiresorptive therapy. In the future, new agents modulating bone turnover and skeletal muscle metabolism will be available for testing in these subjects. [less ▲]Detailed reference viewed: 23 (3 ULg) Defining thermal comfort boundaries for heating and cooling demand estimation in Iran's urban settlementsRoshan, GhR.; Farrokhzad, M.; Attia, Shady in Building & Environment (2017), 121Iran has diverse climate variability, comfort boundaries for each geographic region must be defined in order to present current architectural design recommendations and proper mechanical systems design to ... [more ▼]Iran has diverse climate variability, comfort boundaries for each geographic region must be defined in order to present current architectural design recommendations and proper mechanical systems design to meet building's heating and cooling energy demand. Therefore, two components of the temperature and relative humidity of 148 stations with the longest common statistical period of twenty years (1994–2014), which have been in daily scale were selected to calibrate and redefine the thermal boundary conditions in Iran. Givoni chart was used to define and visualize the bioclimatic conditions in buildings. The results of this study indicate that only 18% of the 148 stations days, falls in the thermal comfort bioclimatic conditions. After calibration of the base comfort temperature, we found that the upper threshold of this component varies from at least 22.62 °C for Ardebil to 25.94 °C for Dorudzan station and the low threshold of this component belongs to Ardebil with at least 20.13 °C up to its maximum value with 22 °C which belongs to Dorudzan. Spatial distribution of cooling and heating days show that their maximum threshold has been for cores in Northeastern half of Iran, Iran's Western half and some Central parts of Iran and the minimum threshold of these two components belongs to the beaches of north and south of the country. The findings present updated thermal comfort boundaries that can be used by architects, engineers and policy makers to achieve, in turn, more energy efficient homes and high quality indoor and outdoor living environments. [less ▲]Detailed reference viewed: 45 (4 ULg) First Characterisation of Volatile Organic Compounds Emitted by Banana PlantsBerhal, Chadi ; De Clerck, Caroline ; Fauconnier, Marie-Laure et alin Scientific Reports (2017)Banana (Musa sp.) ranks fourth in term of worldwide fruit production, and has economical and nutritional key values. The Cavendish cultivars correspond to more than 90% of the production of dessert banana ... [more ▼]Banana (Musa sp.) ranks fourth in term of worldwide fruit production, and has economical and nutritional key values. The Cavendish cultivars correspond to more than 90% of the production of dessert banana while cooking cultivars are widely consumed locally around the banana belt production area. Many plants, if not all, produce Volatile Organic Compounds (VOCs) as a means of communication with their environment. Although flower and fruit VOCs have been studied for banana, the VOCs produced by the plant have never been identified despite their importance in plant health and development. A volatile collection methodology was optimized to improve the sensitivity and reproducibility of VOCs analysis from banana plants. We have identified 11 VOCs for the Cavendish, mainly (E,E)-α-farnesene (87.90 ± 11.28 ng/μl), methyl salicylate (33.82 ± 14.29) and 6-methyl-5-hepten-2-one (29.60 ± 11.66), and 14 VOCs for the Pacific Plantain cultivar, mainly (Z,E)-α-farnesene (799.64 ± 503.15), (E,E)-α-farnesene (571.24 ± 381.70) and (E) β ocimene (241.76 ± 158.49). This exploratory study paves the way for an in-depth characterisation of VOCs emitted by Musa plants. [less ▲]Detailed reference viewed: 48 (4 ULg) Effects of isolated versus combined learning enactments in an online courseVerpoorten, Dominique ; Westera, Wim; Specht, Marcusin International Journal of Technology Enhanced Learning (2017), 9(2), 169-185In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations ... [more ▼]In a controlled experiment on the effects of frequent and local digital annotations, 137 volunteers covered an online course under three possible conditions: no/free/question-based digital annotations. Results show no difference in performance between groups when annotation behaviour is considered in isolation. However, analyses conducted within treatments provide indications of a positive impact on performance when annotation rates are taken into consideration, and coupled with other enactments tracked in the course. Combined in engagement profiles (Learning DNAs), these enactments suggest that what makes active learning efficient might be an ongoing crisscrossing between a firstorder learning activity (the study of the course) and a series of second order activities, such as making notes. Students who manage to coordinate these activities at a higher rate perform better. This observation opens a line of reasoning about what determines the quality of a mental engagement in a learning task, in terms of balance and rotation of cognitive and metacognitive operations. [less ▲]Detailed reference viewed: 54 (15 ULg) Straightforward prediction of the Ni1−xO layers stoichiometry by using optical and electrochemical measurementsManceriu, Laura ; Colson, Pierre ; Maho, Anthony et alin Journal of Physics : D Applied Physics (2017), 50In this study, we propose a straightforward method for x determination in sub-stoichiometric nickel oxide (Ni1−xO) films prepared by ultrasonic spray pyrolysis on fluor-tin oxide (FTO) substrates by ... [more ▼]In this study, we propose a straightforward method for x determination in sub-stoichiometric nickel oxide (Ni1−xO) films prepared by ultrasonic spray pyrolysis on fluor-tin oxide (FTO) substrates by varying the post-deposition thermal treatment. The Ni3+ concentration, the flat band potential (Φfb) and the open circuit potential (Voc) were determined by electrochemical impedance analysis in aqueous media and correlated to the transmission of Ni1−xO films. An x-ray photoelectron spectroscopy study was also performed to quantify the amount of Ni3+ in the films and compare it with the one determined by electrochemical analysis. The electrochromic behavior of the Ni1−xO films in non-aqueous electrolyte was investigated as well. With increasing Ni3+ concentration the films became more brownish and more conductive, both Voc and Φfb values increased. Calibration curves of transmission at 550 nm or open circuit potential versus carrier concentration were plotted and allowed the prediction of x in an unknown Ni1−xO sample. The Ni1−xO films characterized by the highest Ni3+ concentration have a darker colored state but lower transmission modulation, due to their reduced specific surface and increased crystallinity. [less ▲]Detailed reference viewed: 12 (3 ULg) Risk Assessment of Florists Exposed to Pesticide Residues through Handling of Flowers and Preparing BouquetsToumi, Khaoula ; Laure, Joly; Vleminckx, Christiane et alin International Journal of Environmental Research and Public Health (2017), 14(5)Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty ... [more ▼]Abstract: Flowers are frequently treated with pesticides and, as a result, florists handling daily a large number of flowers can be exposed to pesticide residues. A study was conducted among twenty volunteer florists located in Namur Province and in the Brussels Capital Region of Belgium in order to assess their potential dermal exposure to dislodgeable pesticide residues transferred from flowers to hands. Two pairs of cotton gloves were worn during two consecutive half days while handling flowers and preparing bouquets (from min 2 h to max 3 h/day). The residual pesticide deposits on the glove samples were extracted with a multi-residue Quick Easy Cheap Effective Rugged Safe (QuEChERS) method and analyzed by a combination of gas and liquid chromatography tandem mass spectrometry (GC-MS/MS and LC-MS/MS) by an accredited laboratory. A total of 111 active substances (mainly insecticides and fungicides) were detected, with an average of 37 active substances per sample and a total concentration per glove sample of 22.22 mg/kg. Several predictive levels of contamination were considered to assess the risk. The potential dermal exposures (PDE) of florists were estimated at the average, for different percentiles, and at the maximum concentration of residues in samples. At the PDE P90 and at the PDEMAX (or worst case) values, three and five active substances respectively exceed the Acceptable Operator Exposure Level (AOEL), indicating risk situations. For the systemic exposure (SE), one active substance (clofentezine) exceeds the AOEL at the P90 predictive level. In the worst case, SEMAX (at the maximum concentrations), four active substances (clofentezine, famoxadone, methiocarb, and pyridaben) exceed their respective AOEL values. Among the 14 most frequently detected active substances, two have SEMAX values exceeding the AOEL. Exposure could be particularly critical for clofentezine with an SEMAX value four times higher than the AOEL (393%). The exposure of florists appeared to be an example of a unique professional situation in which workers are exposed regularly to both a very high number of toxic chemicals and rather high concentration levels. Therefore the priority should be to raise the level of awareness among the florists who must change their habits and practices if they want to minimize their exposure. [less ▲]Detailed reference viewed: 32 (2 ULg) Recovering unlawful advantages in the context of EU State aid tax ruling investigationsVan Cleynenbreugel, Pieter in Market and Competition Law Review (2017), 1(1), 15-48The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of ... [more ▼]The European Commission has recently begun to focus increasingly on the compatibility of Member States’ tax ruling procedures with EU State aid law. In that respect, it has ordered the recovery of unlawfully granted advantages through those procedures. This article examines to what extent the application of EU law principles of legitimate expectations and legal certainty are to take stock in State aid recovery proceedings of this particular legal certainty-enhancing and legitimate expectationscreating tax ruling context. It additionally questions whether recovery in this particular context should be tailored to the specific national ruling framework having resulted in the advantage granted in violation of Article 107 TFEU [less ▲]Detailed reference viewed: 9 (0 ULg) Comparative Feeding Ecology of Cardinalfishes (Apogonidae) at Toliara Reef, MadagascarFrederich, Bruno ; Michel, Loïc ; Zaeytydt, Esther et alin Zoological Studies (2017), 56(10), 1-14Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones ... [more ▼]Despite their importance in coral reef ecosystem function and trophodynamics, the trophic ecology of nocturnal fishes (e.g. Apogonidae, Holocentridae, Pempheridae) is by far less studied than diurnal ones. The Apogonidae (cardinalfishes) include mostly carnivorous species and evidence of trophic niche partitioning among sympatric cardinalfishes is still limited. The present study combines stomach contents and stable isotope analyses to investigate the feeding ecology of an assemblage of eight cardinalfishes from the Great Reef of Toliara (SW Madagascar). δ13C and δ15N of fishes ranged between -17.49‰ and -10.03‰ and between 6.28‰ and 10.74‰, respectively. Both stomach contents and stable isotopes showed that they feed on planktonic and benthic animal prey in various proportions. Previous studies were able to group apogonids in different trophic categories but such a discrimination is not obvious here. Large intra-specific variation in the stomach contents and temporal variation in the relative contribution of prey to diet support that all apogonids should be considered as generalist, carnivorous fishes. However the exploration of the isotopic space revealed a clear segregation of isotopic niches among species, suggesting a high level of resource partitioning within the assemblage. According to low inter-specific variation in stomach content compositions, we argue that the differences in isotopic niches could be driven by variation in foraging locations (i.e. microhabitat segregation) and physiology among species. Our temporal datasets demonstrate that the trophic niche partitioning among cardinalfishes and the breadth of their isotopic niches are dynamic and change across time. Factors driving this temporal variation need to be investigated in further studies. [less ▲]Detailed reference viewed: 48 (4 ULg) How does policy learning occur? The case of Belgian mental health care reformsThunus, Sophie ; Schoenaers, Frédéric in Policy and Society (2017)This article asks how policy learning is achieved and whether and how it impacts on policy change. By drawing on the empirical case of Belgian mental health reforms, it shows that policy learning occurs ... [more ▼]This article asks how policy learning is achieved and whether and how it impacts on policy change. By drawing on the empirical case of Belgian mental health reforms, it shows that policy learning occurs through the very practice of policy-making. In-depth analyses of the process of preparing and devising, a current reform of mental health care delivery, called Reform 107, evidence that the transformation of policy learning – through verbal expression, inscription in documents or enactment in social situations such as meetings – is crucial to its impact on policy change. A phenomenological approach to knowledge in policy helps to perceive and describe the transformation of policy learning through practical actions and interactions involved in devising policy change. Analytically, looking at this transformation entails shifting the focus from big and visible changes in policy objectives and instruments to micro policy practices such as meeting and writing documents. Placing the focus on micro policy practices should not lead, however, to a disregard for the social context in which they develop. The interactionist concept of linked ecologies provides the means to consider social regulations influencing policy learning without underestimating their very ephemeral and contingent nature [less ▲]Detailed reference viewed: 47 (7 ULg) Dynamic of soil drying close to saturation: What can we learn from a comparison between X-ray computed microtomography and the evaporation method?Parvin, Nargish ; Beckers, Eléonore ; Plougonven, Erwan et alin Geoderma (2017), 302The soil water retention curve (SWRC) is a unique relationship between water content and soil water potential. SWRC in near saturation gives the dimension of soil macroporosity which plays an important ... [more ▼]The soil water retention curve (SWRC) is a unique relationship between water content and soil water potential. SWRC in near saturation gives the dimension of soil macroporosity which plays an important role in water translocation into soil. Thus, the accurate measurement of SWRC is crucial. The aim of this study is to compare SWRC obtained through two different methods: X-ray computed microtomography (X-ray CT) and evaporation method by HYPROP device. Three different depths (0–10, 25–30 and 45–60 cm) are considered for soil sampling. The results showed significant differences in SWRC between the techniques. The SWRC from X-ray CT showed more volumetric water content at 25–30 cm (0.044) and 45–60 cm (0.024) than evaporation at saturation (0 kPa) in cases where the macroporosity was higher. Macropores may have connections with neighbouring pores of smaller sizes. Hence we assume that these pores can be observed through X-ray CT but cannot be evaluated by evaporation. As macropores with narrow opening do not evaporate at very low tension. These pores therefore got empty at relatively higher tension. Consequently, SWRC near saturation appeared rather flatter with the evaporation method where the X-ray CT presented deviation. Accordingly, interpretation of macro pores from SWRC through evaporation method would give comparatively smaller volume of macropores than they really are. Pore morphology and other hydraulic functions of soil, for example, mean connection surface of pores, hydraulic conductivity, and the efficiency of water conducting macropores also support the X-ray CT findings. [less ▲]Detailed reference viewed: 26 (7 ULg) Study of Meta-analysis strategies for network inference using information-theoretic approachesPham, Cam Ngoc ; Haibe-Kains; Bellot, Pau et alin BioData Mining (2017)Detailed reference viewed: 20 (2 ULg) Cow milk coagulation: process description, variation factors and evaluation methodologies. A review.Troch, Thibault; Lefebure, Emilie ; Baeten, Vincent et alin Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment (2017), 21Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is ... [more ▼]Introduction. For dairy producers who want to transform their milk, the ability of milk to coagulate is an important parameter. It makes it possible to transform milk into cheese. Therefore, it is necessary to understand the coagulation process and the techniques to measure it in order to achieve the best transformation performance. The objective of this review is to describe the milk coagulation process, the factors influencing it and the methods for measuring the coagulation of milk at lab level. Literature. The processing of milk into cheese involves three steps: coagulation, dewatering and refining. Coagulation is a key step which involves the use of rennet and depends on several parameters (pH, calcium content, temperature, etc.). Some milks never coagulate. To measure the coagulation ability of milk and identify different parameters in milk coagulation properties, the Formagraph, the computerized renneting meter and the Optigraph have been developed (reference methods). Equations have been developed using infrared spectrometry to predict the parameters obtained by the reference methods. Conclusions. The milk coagulation mechanism is known. However, the issue of non-coagulating milk persists and represents a real challenge in terms of yield. The use of infrared is a faster alternative to reference methods that measure the coagulation properties of milk, but still requires an improvement in prediction equations. [less ▲]Detailed reference viewed: 13 (0 ULg) From the shortest to the tallestBeckers, Albert in Annales d'Endocrinologie (2017), 78Detailed reference viewed: 7 (0 ULg) Adipsic diabetes insipidus revealing a bifocal intracranial germinomaKREUTZ, Julie ; Potorac, Iulia ; LUTTERI, Laurence et alin Annales d'Endocrinologie (2017)Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the ... [more ▼]Abstract Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient. Management of intracranial germ-cell tumors is made complex by the wide range of histological features. Although germinomas have a generally better prognosis than most nongerminomatous tumors, they can have severe or even life-threatening presentations. Adipsic diabetes insipidus is one such severe presentation and its rarity can make it difficult to recognize and manage. Awareness of this potential entity is therefore important for clinical practice. Le diabète insipide adipsique est une des rares complications des tumeurs intracrâniennes. Il associe une baisse de la sécrétion d’hormone antidiurétique à une perte de la sensation de soif et ilsignale souvent la présence d’une lésion qui atteint ou envahit l’hypothalamus. Nous présentons le cas d’une patiente avec un germinome intracrânien bifocal diagnostiqué devant un tableau de diabète insipide adipsique. À notre connaissance, il s’agit du premier cas de la littérature d’un diabète insipide révélant un germinome intracrânien. La prise en charge des tumeurs germinales intracrâniennes est complexe du fait des phénotypes histologiques divers. Bien que les germinomes ont généralement un meilleur pronostic que les tumeurs non-germinomateuses, ils peuvent avoir des présentations sévères. Le diabète insipide adipsique est une de ces présentations sévères et sa rareté peut rendre son diagnostic et sa prise en charge difficiles. La reconnaissance de cette entité potentielle est, dès lors, importante pour la pratique clinique [less ▲]Detailed reference viewed: 35 (6 ULg) AIP mutations and gigantismRostomyan, Liliya ; Potorac, Iulia ; BECKERS, Pablo et alin Annales d'Endocrinologie (2017)AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated ... [more ▼]AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤ 30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Bien que les mutations du gène AIP soient rares dans les cas d’acromégalie sporadique, l’importance de ces mutations est établie dans des populations spécifiques de patients telles que les patients qui souffrent de familial isolated pituitary adenomas (FIPA), de gigantisme ou qui présentent un macroadénome hypophysaire avant l’âge de 30 ans. C’est dans le gigantisme qu’elles sont le plus fréquemment retrouvées (29 % des géants présentent une mutation de ce gène). Dans ces populations, nos données suggèrent qu’il est utile de réaliser un screening ciblé pour les mutations ou délétions du gène AIP. La reconnaissance précoce des cas d’acromégalie et de gigantisme permet une évaluation clinique et un traitement appropriés de ces patients. Elle contribue à améliorer les résultats des traitements tant en terme de croissance excessive qu’en ce qui concerne les comorbidités liées à l’acromégalie. [less ▲]Detailed reference viewed: 41 (20 ULg) Du militantisme à la commémoration. Un monument en hommage à l’immigration espagnole à LiègeMolina Marmol, Maïté in Communications (2017), 100Detailed reference viewed: 12 (1 ULg) Spray droplet impaction outcomes for different plant species and spray formulationsMassinon, Mathieu ; De Cock, Nicolas ; Forster, W. Alison et alin Crop Protection (2017), 99A track-sprayer combined with a high-speed camera were used to visualize and identify droplet impaction outcomes for three formulations (water, 0.1% LI 700® (lecithin, a mixture of soya oils, propionic ... [more ▼]A track-sprayer combined with a high-speed camera were used to visualize and identify droplet impaction outcomes for three formulations (water, 0.1% LI 700® (lecithin, a mixture of soya oils, propionic acid and surfactants) in water and 0.1% Pulse® (non-ionic surfactant, trisiloxane ethoxylate) in water) on four plant species (bean (Vicia faba L.), avocado (Persea americana L.), barnyard grass (Echinochloa crus-galli L. P. Beauv.) and cabbage (Brassica oleracea L.)) selected to represent a wide range of leaf surface characters. Droplet sizes and velocities were measured by image analysis and a multiple hypothesis tracking algorithm. Impaction outcomes were categorized into adhesion, bounce, or shatter. The probability of each outcome was estimated from logistic regression models related to the dimensionless Weber number. This approach is in contrast to various deterministic threshold criteria for droplet bounce or shatter that have been used to model droplet impaction events on leaves. It also provides a simple visual and numerical presentation of the complexity of impaction processes, and the relative influence of leaf surface character versus formulation for droplets with different impaction energies. [less ▲]Detailed reference viewed: 33 (6 ULg) Model-based classification of CPT data and automated lithostratigraphic mapping for high-resolution characterization of a heterogeneous sedimentary aquiferRogiers, Bart; Mallants, Dirk; Batelaan, Okke et alin PLoS ONE (2017), 12(5), 0176656Cone penetration testing (CPT) is one of the most efficient and versatile methods currently available for geotechnical, lithostratigraphic and hydrogeological site characterization. Currently available ... [more ▼]Cone penetration testing (CPT) is one of the most efficient and versatile methods currently available for geotechnical, lithostratigraphic and hydrogeological site characterization. Currently available methods for soil behaviour type classification (SBT) of CPT data however have severe limitations, often restricting their application to a local scale. For parameterization of regional groundwater flow or geotechnical models, and delineation of regional hydro- or lithostratigraphy, regional SBT classification would be very useful. This paper investigates the use of model-based clustering for SBT classification, and the influence of different clustering approaches on the properties and spatial distribution of the obtained soil classes. We additionally propose a methodology for automated lithostratigraphic mapping of regionally occurring sedimentary units using SBT classification. The methodology is applied to a large CPT dataset, covering a groundwater basin of ~60 km2 with predominantly unconsolidated sandy sediments in northern Belgium. Results show that the model-based approach is superior in detecting the true lithological classes when compared to more frequently applied unsupervised classification approaches or literature classification diagrams. We demonstrate that automated mapping of lithostratigraphic units using advanced SBT classification techniques can provide a large gain in efficiency, compared to more time-consuming manual approaches and yields at least equally accurate results. [less ▲]Detailed reference viewed: 15 (1 ULg) Polyphenolic profile and biological activities of the leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray (Cucurbitaceae)Ielciu, Irina-Ioana ; Vlase, Laurian; Frederich, Michel et alin Farmacia (2017), 65(2), 179-183The aim of the present study consisted in the quantification of the polyphenols in leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray and testing its biological potential. Analysis of ... [more ▼]The aim of the present study consisted in the quantification of the polyphenols in leaves and aerial parts of Echinocystis lobata (Michx.) Torr. et A.Gray and testing its biological potential. Analysis of polyphenols was performed by a HPLC-MS method. Antioxidant activity of the extracts was tested by DPPH, CUPRAC, FRAP, TEAC, EPR and SNPAC assays. Cytotoxic activity was assessed on cancerous and healthy cell lines. Anti-plasmodial tests were performed on two strains of Plasmodium falciparum. Ethanolic extracts of E. lobata contain mainly p-coumaric acid, isoquercitrin, rutin, quercitrin and kaempferol. Biological assays showed a significant antioxidant effect and no cytotoxic and anti-plasmodial activity. These results offer a new perspective on E. lobata, proving it as an important source of antioxidant compounds. [less ▲]Detailed reference viewed: 32 (5 ULg) Surrogate Generation and Evaluation for Biodiesel and Its Mixtures with Fossil DieselReiter, Anton M.; Schubert, Nikolai; Pfennig, Andreas et alin Energy & Fuels (2017), 31In this paper a precedently developed surrogate optimization algorithm for fossil fuels, which originally allowed simultaneous fitting of the true boiling point (TBP) curve, the liquid density at 15 °C ... [more ▼]In this paper a precedently developed surrogate optimization algorithm for fossil fuels, which originally allowed simultaneous fitting of the true boiling point (TBP) curve, the liquid density at 15 °C, and the cetane number, is refined toward its application to biodiesel and its mixtures with fossil diesel. For this purpose, the algorithm is extended (1) to also include fitting of the kinematic viscosity at 40 °C and (2) to account for peculiarities of biodiesel concerning its narrow boiling range and compensation of systematic errors of measured boiling curves. To illustrate these improvements, first, the algorithm is applied to property estimation and surrogate optimization of three different biodiesel fuels, for which surrogates consisting of one to three components are proposed. Second, a surrogate for a commercial European fossil diesel is calculated and produced in lab-scale. Finally, the algorithm is used for surrogate optimization and property estimation of mixtures of biodiesel and fossil diesel, considering fractions of biodiesel of 7% and 20% per volume. It is shown that the improved algorithm is capable of reliably optimizing surrogates for fuels containing both biogenic and fossil components. [less ▲]Detailed reference viewed: 12 (2 ULg) An Improved On-line Contingency Screening for Power System Transient Stability AssessmentWeckesser, Johannes ; Jóhannsson, Hjörtur; Glavic, Mevludin et alin Electric Power Components & Systems (2017)This paper presents a contingency screening method and a framework for its on-line implementation. The proposed method carries out contingency screening and on-line stability assessment with respect to ... [more ▼]This paper presents a contingency screening method and a framework for its on-line implementation. The proposed method carries out contingency screening and on-line stability assessment with respect to first-swing transient stability. For that purpose, it utilizes the single machine equivalent method and aims at improving the prior developed contingency screening approaches. In order to determine vulnerability of the system with respect to a particular contingency, only one time-domain simulation needs to be performed. An early stop criteria is proposed so that in a majority of the cases the simulation can be terminated after a few hundred milliseconds of simulated system response. The method’s outcome is an assessment of the system’s stability and a classification of each considered contingency. The contingencies are categorized by exploiting parameters of an equivalent one machine infinite bus system. A novel island detection approach, appropriate for an on-line application since it utilizes efficient algorithms from graph theory and enables stability assessment of individual islands, is also introduced. The New England and New York system as well as the large-scale model of the Continental-European interconnected system are used to test the proposed method with respect to assessment accuracy and computation time. [less ▲]Detailed reference viewed: 21 (6 ULg) The 67P/Churyumov-Gerasimenko observation campaign in support of the Rosetta missionSnodgrass, C.; A'Hearn, M. F.; Aceituno, F. et alin Philosophical Transactions of the Royal Society of London Series A (2017), 375We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko ... [more ▼]We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of the mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively `well-behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit to orbit. Comparison between this large collection of telescopic observations and the in situ results from Rosetta will allow us to better understand comet coma chemistry and structure. This work is just beginning as the mission ends-in this paper, we present a summary of the ground-based observations and early results, and point to many questions that will be addressed in future studies. This article is part of the themed issue 'Cometary science after Rosetta'. [less ▲]Detailed reference viewed: 19 (0 ULg) The Spitzer search for the transits of HARPS low-mass planets. II. Null results for 19 planetsGillon, Michaël ; Demory, B.-O.; Lovis, C. et alin Astronomy and Astrophysics (2017), 601Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of ... [more ▼]Short-period super-Earths and Neptunes are now known to be very frequent around solar-type stars. Improving our understanding of these mysterious planets requires the detection of a significant sample of objects suitable for detailed characterization. Searching for the transits of the low-mass planets detected by Doppler surveys is a straightforward way to achieve this goal. Indeed, Doppler surveys target the most nearby main-sequence stars, they regularly detect close-in low-mass planets with significant transit probability, and their radial velocity data constrain strongly the ephemeris of possible transits. In this context, we initiated in 2010 an ambitious Spitzer multi-Cycle transit search project that targeted 25 low-mass planets detected by radial velocity, focusing mainly on the shortest-period planets detected by the HARPS spectrograph. We report here null results for 19 targets of the project. For 16 planets out of 19, a transiting configuration is strongly disfavored or firmly rejected by our data for most planetary compositions. We derive a posterior probability of 83% that none of the probed 19 planets transits (for a prior probability of 22%), which still leaves a significant probability of 17% that at least one of them does transit. Globally, our Spitzer project revealed or confirmed transits for three of its 25 targeted planets, and discarded or disfavored the transiting nature of 20 of them. Our light curves demonstrate for Warm Spitzer excellent photometric precisions: for 14 targets out of 19, we were able to reach standard deviations that were better than 50 ppm per 30 min intervals. Combined with its Earth-trailing orbit, which makes it capable of pointing any star in the sky and to monitor it continuously for days, this work confirms Spitzer as an optimal instrument to detect sub-mmag-deep transits on the bright nearby stars targeted by Doppler surveys. The photometric and radial velocity time series used in this work are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A117 [less ▲]Detailed reference viewed: 12 (1 ULg) A threshold-based weather model for predicting stripe rust infection in winter wheatEl Jarroudi, Moussa ; Kouadio, Louis; Bock, Clive et alin Plant Disease (2017), 101(693-703), Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions ... [more ▼]Wheat stripe rust (caused by Puccinia striiformis f. sp. tritici) is a major threat in most wheat growing regions worldwide, which potentially causes substantial yield losses when environmental conditions are favorable. Data from 1999-2015 for three representative wheat-growing sites in Luxembourg were used to develop a threshold-based weather model for predicting wheat stripe rust. First, the range of favorable weather conditions using a Monte Carlo simulation method based on the Dennis model were characterized. Then, the optimum combined favorable weather variables (air temperature, relative humidity, and rainfall) during the most critical infection period (May-June) was identified and was used to develop the model. Uninterrupted hours with such favorable weather conditions over each dekad (i.e., 10-day period) during May-June were also considered when building the model. Results showed that a combination of relative humidity > 92% and 4°C < temperature < 16°C for a minimum of 4 continuous hours, associated with rainfall ≤ 0.1 mm (with the dekad having these conditions for 5-20% of the time), were optimum to the development of a wheat stripe rust epidemic. The model accurately predicted infection events: probabilities of detection were ≥ 0.90 and false alarm ratios were ≤ 0.38 on average, and critical success indexes ranged from 0.63 to 1. The method is potentially applicable to studies of other economically important fungal diseases of other crops or in different geographical locations. If weather forecasts are available, the threshold-based weather model can be integrated into an operational warning system to guide fungicide applications. [less ▲]Detailed reference viewed: 38 (8 ULg) Gaia Data Release 1. Open cluster astrometry: performance, limitations, and future prospectsGaia Collaboration, ; van Leeuwen, F.; Vallenari, A. et alin Astronomy and Astrophysics (2017), 601Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and ... [more ▼]Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information.
Aims: We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters.
Methods: Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed.
Results: Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters.
Conclusions: The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs. Tables D.1 to D.19 are also available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/601/A19 [less ▲]Detailed reference viewed: 30 (4 ULg) First constraints on the magnetic field strength in extra-Galactic stars: FORS2 observations of Of?p stars in the Magellanic CloudsBagnulo, S.; Nazé, Yaël ; Howarth, I. D. et alin Astronomy and Astrophysics (2017), 601(A136), 10Massive O-type stars play a dominant role in our Universe, but many of their properties remain poorly constrained. In the last decade magnetic fields have been detected in all Galactic members of the ... [more ▼]Massive O-type stars play a dominant role in our Universe, but many of their properties remain poorly constrained. In the last decade magnetic fields have been detected in all Galactic members of the distinctive Of?p class, opening the door to a better knowledge of all O-type stars. With the aim of extending the study of magnetic massive stars to nearby galaxies, to better understand the role of metallicity in the formation of their magnetic fields and magnetospheres, and to broaden our knowledge of the role of magnetic fields in massive star evolution, we carried out spectropolarimetry of five extra-Galactic Of?p stars, and of a couple of dozen neighbouring stars. We were able to measure magnetic fields with typical error bars from 0.2 to 1.0 kG, depending on the apparent magnitude and on weather conditions. No magnetic field was firmly detected in any of our measurements, but we were able to estimate upper limits on the field values of our target stars. One of our targets, 2dFS 936, exhibited an unexpected strengthening of emission lines. We confirm the unusual behaviour of BI 57, which exhibits a 787 d period with two photometric peaks and one spectroscopic maximum. The observed strengthening of the emission lines of 2dFS 936, and the lack of detection of a strong magnetic field in a star with such strong emission lines is at odd with expectations. Together with the unusual periodic behaviour of BI 57, it represents a challenge for the current models of Of?p stars. The limited precision that we obtained in our field measurements (in most cases as a consequence of poor weather) has led to field-strength upper limits that are substantially larger than those typically measured in Galactic magnetic O stars. Further higher precision observations and monitoring are clearly required. [less ▲]Detailed reference viewed: 26 (3 ULg) How unique is Plaskett's star? A search for organized magnetic fields in short period, interacting or post-interaction massive binary systems★Nazé, Yaël ; Neiner, Coralie; Grunhut, Jason et alin Monthly Notices of the Royal Astronomical Society (2017), 467Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have ... [more ▼]Amongst O-type stars with detected magnetic fields, the fast rotator in the close binary called Plaskett's star shows a variety of unusual properties. Since strong binary interactions are believed to have occurred in this system, one may wonder about their potential role in generating magnetic fields. Stokes V spectra collected with the low-resolution FORS2 and high-resolution ESPaDOnS and Narval spectropolarimeters were therefore used to search for magnetic fields in 15 interacting or post-interaction massive binaries. No magnetic field was detected in any of them, with 0 G always being within 2σ of the derived values. For 17 out of 25 stars in the systems observed at high resolution, the 90 per cent upper limit on the individual dipolar fields is below the dipolar field strength of Plaskett's secondary; a similar result is found for five out of six systems observed at low resolution. If our sample is considered to form a group of stars sharing similar magnetic properties, a global statistical analysis results in a stringent upper limit of ∼200 G on the dipolar field strength. Moreover, the magnetic incidence rate in the full sample of interacting or post-interaction systems (our targets + Plaskett's star) is compatible with that measured from large surveys, showing that they are not significantly different from the general O-star population. These results suggest that binary interactions play no systematic role in the magnetism of such massive systems. [less ▲]Detailed reference viewed: 21 (2 ULg) Peculiar architectures for the WASP-53 and WASP-81 planet-hosting systems★Triaud, Amaury H. M. J.; Neveu-VanMalle, Marion; Lendl, Monika et alin Monthly Notices of the Royal Astronomical Society (2017), 467We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the ... [more ▼]We report the detection of two new systems containing transiting planets. Both were identified by WASP as worthy transiting planet candidates. Radial velocity observations quickly verified that the photometric signals were indeed produced by two transiting hot Jupiters. Our observations also show the presence of additional Doppler signals. In addition to short-period hot Jupiters, we find that the WASP-53 and WASP-81 systems also host brown dwarfs, on fairly eccentric orbits with semimajor axes of a few astronomical units. WASP-53c is over 16 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB] and WASP-81c is 57 M[SUB]Jup[/SUB]sin i[SUB]c[/SUB]. The presence of these tight, massive companions restricts theories of how the inner planets were assembled. We propose two alternative interpretations: the formation of the hot Jupiters within the snow line or the late dynamical arrival of the brown dwarfs after disc dispersal. We also attempted to measure the Rossiter-McLaughlin effect for both hot Jupiters. In the case of WASP-81b, we fail to detect a signal. For WASP-53b, we find that the planet is aligned with respect to the stellar spin axis. In addition we explore the prospect of transit-timing variations, and of using Gaia's astrometry to measure the true masses of both brown dwarfs and also their relative inclination with respect to the inner transiting hot Jupiters. [less ▲]Detailed reference viewed: 10 (1 ULg) An Optical and Infrared Photometric Study of the Young Open Cluster IC 1805 in the Giant H ii Region W4 †Sung, Hwankyung; Bessell, Michael S.; Chun, Moo-Young et alin Astrophysical Journal Supplement Series (2017), 230We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from ... [more ▼]We present deep wide-field optical CCD photometry and mid-infrared Spitzer/IRAC and MIPS 24 μm data for about 100,000 stars in the young open cluster IC 1805. The members of IC 1805 were selected from their location in the various color–color and color–magnitude diagrams, and the presence of Hα emission, mid-infrared excess emission, and X-ray emission. The reddening law toward IC 1805 is nearly normal (R [SUB] V [/SUB] = 3.05 ± 0.06). However, the distance modulus of the cluster is estimated to be 11.9 ± 0.2 mag (d=2.4+/- 0.2 kpc) from the reddening-free color–magnitude diagrams, which is larger than the distance to the nearby massive star-forming region W3(OH) measured from the radio VLBA astrometry. We also determined the age of IC 1805 ({τ }[SUB]{MSTO[/SUB]}=3.5 Myr). In addition, we critically compared the age and mass scale from two pre-main-sequence evolution models. The initial mass function with a Salpeter-type slope of Γ = ‑1.3 ± 0.2 was obtained and the total mass of IC 1805 was estimated to be about 2700 ± 200 {M}[SUB]ȯ [/SUB]. Finally, we found our distance determination to be statistically consistent with the Tycho-Gaia Astrometric Solution Data Release 1, within the errors. The proper motion of the B-type stars shows an elongated distribution along the Galactic plane, which could be explained by some of the B-type stars being formed in small clouds dispersed by previous episodes of star formation or supernova explosions. The optical imaging data in this article were gathered with two facilities: the AZT-22 1.5 m telescope at Maidanak Astronomical Observatory in Uzbekistan and the Canada–France–Hawaii Telescope (CFHT), which is operated by the National Research Council of Canada, the Institut National des Sciences de l’Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. [less ▲]Detailed reference viewed: 19 (2 ULg) Ambiguities in gravitational lens models: the density field from the source position transformationUnruh, Sandra; Schneider, Peter; Sluse, Dominique in Astronomy and Astrophysics (2017), 601Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be ... [more ▼]Strong gravitational lensing is regarded as the most precise technique to measure the mass in the inner region of galaxies or galaxy clusters. In particular, the mass within one Einstein radius can be determined with an accuracy of the order of a few percent or better, depending on the image configuration. For other radii, however, degeneracies exist between galaxy density profiles, precluding an accurate determination of the enclosed mass. The source position transformation (SPT), which includes the well-known mass-sheet transformation (MST) as a special case, describes this degeneracy of the lensing observables in a more general way. In this paper we explore properties of an SPT, removing the MST to leading order, that is we consider degeneracies which have not been described before. The deflection field \ahat(čθ) resulting from an SPT is not curl-free in general, and thus not a deflection that can be obtained from a lensing mass distribution. Starting from a variational principle, we construct lensing potentials that give rise to a deflection field \atilde, which differs from \ahat by less than an observationally motivated upper limit. The corresponding mass distributions from these "valid" SPTs are studied: their radial profiles are modified relative to the original mass distribution in a significant and non-trivial way, and originally axi-symmetric mass distributions can obtain a finite ellipticity. These results indicate a significant effect of the SPT on quantitative analyses of lens systems. We show that the mass inside the Einstein radius of the original mass distribution is conserved by the SPT; hence, as is the case for the MST, the SPT does not affect the mass determination at the Einstein radius. Furthermore, we analyse a degeneracy between two lens models, empirically found previously, and show that this degeneracy can be interpreted as being due to an SPT. Thus, degeneracies between lensing mass distributions are not just a theoretical possibility, but do arise in actual lens modeling. [less ▲]Detailed reference viewed: 18 (3 ULg) π Aquarii is another γ Cassiopeiae objectNazé, Yaël ; Rauw, Grégor ; Cazorla, Constantin in Astronomy and Astrophysics (2017), 602The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly ... [more ▼]The γ Cas category is a subgroup of Be stars displaying a strong, hard, and variable thermal X-ray emission. An XMM-Newton observation of π Aqr reveals spectral and temporal characteristics that clearly make this Be star another member of the γ Cas category. Furthermore, π Aqr is a binary but, contrary to γ Cas, the nature of the companion to the Be star is known; it is a non-degenerate (stellar) object and its small separation from the Be star does not leave much room for a putative compact object close to the Be disk. This renders the accretion scenario difficult to apply in this system, and, hence, this discovery favors a disk-related origin for the γ Cas phenomenon. Based on observations collected with the ESA science mission XMM-Newton, an ESA Science Mission with instruments and contributions directly funded by ESA Member States and the USA (NASA). [less ▲]Detailed reference viewed: 18 (3 ULg) Study of the plutino object (208996) 2003 AZ84 from stellar occultations: size, shape and topographic featuresDias-Oliveira, A.; Sicardy, B.; Ortiz, J. L. et alin The Astronomical Journal (2017), 154(1), 13We present results derived from four stellar occultations by the plutino object (208996) 2003~AZ$_{84}$, detected at January 8, 2011 (single-chord event), February 3, 2012 (multi-chord), December 2, 2013 ... [more ▼]We present results derived from four stellar occultations by the plutino object (208996) 2003~AZ$_{84}$, detected at January 8, 2011 (single-chord event), February 3, 2012 (multi-chord), December 2, 2013 (single-chord) and November 15, 2014 (multi-chord). Our observations rule out an oblate spheroid solution for 2003~AZ$_{84}$'s shape. Instead, assuming hydrostatic equilibrium, we find that a Jacobi triaxial solution with semi axes $(470 \pm 20) \times (383 \pm 10) \times (245 \pm 8)$~km % axis ratios $b/a= 0.82 \pm 0.05$ and $c/a= 0.52 \pm 0.02$, can better account for all our occultation observations. Combining these dimensions with the rotation period of the body (6.75~h) and the amplitude of its rotation light curve, we derive a density $\rho=0.87 \pm 0.01$~g~cm$^{-3}$ a geometric albedo $p_V= 0.097 \pm 0.009$. A grazing chord observed during the 2014 occultation reveals a topographic feature along 2003~AZ$_{84}$'s limb, that can be interpreted as an abrupt chasm of width $\sim 23$~km and depth $> 8$~km or a smooth depression of width $\sim 80$~km and depth $\sim 13$~km (or an intermediate feature between those two extremes). [less ▲]Detailed reference viewed: 4 (1 ULg) Identification of non-stationary dynamical systems using multivariate ARMA modelsBertha, Mathieu ; Golinval, Jean-Claude in Mechanical Systems and Signal Processing (2017), 88This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal ... [more ▼]This paper is concerned by the modal identification of time-varying mechanical systems. Based on previous works about autoregressive moving average models in vector form (ARMAV) for the modal identification of linear time invariant systems, and time-varying autoregressive moving average models (TV-ARMA) for the identification of nonstationary systems, a time-varying ARMAV (TV-ARMAV) model is presented for the multivariate identification of time-varying systems. It results in the identification of not only the time-varying poles of the system but also of its respective time-varying mode shapes. The method is applied on a time-varying structure composed of a beam on which a mass is moving. [less ▲]Detailed reference viewed: 35 (8 ULg) Anesthesia Case of the MonthTutunaru, Alexandru-Cosmin ; Sandersen, Charlotte in Journal of the American Veterinary Medical Association [=JAVMA] (2017), 250(9), 984-987Detailed reference viewed: 44 (2 ULg) In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: A historical reviewPestieau, Aude ; Evrard, Brigitte in European Journal of Pharmaceutical Sciences (2017), 102For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at ... [more ▼]For many decades, one of the most critical issues in the pharmaceutical industry has been the poor solubility of some drugs. Indeed, a prerequisite for drug absorption is the presence of dissolved drug at the absorption site and this can be challenging for compounds with low aqueous solubility such as BCS class II (low solubility, high permeability) and IV (low solubility, low permeability) compounds. If the development of oral delivery formulations of these compounds is frequently challenging to formulation scientists in the pharmaceutical industry, the in vitro evaluation of these new formulations is also a great challenge. One alternative approach to overcome the problems encountered with conventional dissolution methods is the use of biphasic dissolution systems. This review provides an overview of the origin and the evolution over time of the biphasic systems and the growing interest among scientists regarding their suitability for establishing in vitro-in vivo correlations. The evolution of these systems and their applications from the 1960s to the present day, such as in system variants and improvements, analysis of complex formulations, discriminatory power, bio-relevance, precipitation and supersaturation visualization, etc. will be discussed. [less ▲]Detailed reference viewed: 24 (5 ULg) From distant neighbours to bedmates: Exploring the synergies between the social economy and sustainable developmentHudon, Marek; Huybrechts, Benjamin in Annals of Public and Cooperative Economics (2017), 88(2), 141-154To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two ... [more ▼]To introduce this special issue we explore the conceptual and practical synergies between the social economy and sustainable development. New empirical evidence is presented on the emergence of these two research fields and the increasing combination of these fields in the literature. Several avenues through which social enterprises can contribute to the transition towards sustainable development are then identified. This is followed by a discussion of how and why the combination can be particularly fruitful both for the social economy and for sustainability transition movements. We also highlight some important challenges facing the social economy with regard to its contribution to sustainable development. Finally we introduce the papers that constitute this special issue and show how they contribute, individually and collectively, to a better understanding of the increasing linkage between the social economy and sustainable development. [less ▲]Detailed reference viewed: 70 (4 ULg) Les pouvoirs publics et les édifices cultuels en BelgiqueHusson, Jean-François in Revue du Droit des Religions (2017), (3), 61-78The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions ... [more ▼]The Belgian regime of relations between the State and religious or philosophical communities results notably in financial supports for buildings used for worship and moral counselling. These interventions are essentially a legacy of the French Concordat, largely unchallenged by the regionalization process. Today, it has to respond to contrasting situations between religions recognized in the 19th century – generally declining – and more recently recognized ones – generally expanding –. An additional complication originates in differences in ownership of the buildings or their classification as listed buildings. After presenting the situation by religious and philosophical community and level of power, this paper questions the equity of the system and addresses the possible developments. [less ▲]Detailed reference viewed: 25 (4 ULg) Modeling the strain localization around an underground gallery with a hydro-mechanical double scale model; effect of anisotropyvan den Eijnden, AP; Bésuelle, Pierre; Collin, Frédéric et alin Computers and Geotechnics (2017), 85Detailed reference viewed: 49 (2 ULg) Martian mesospheric cloud observations by IUVSon MAVEN: Thermal tides coupled to the upper atmosphereStevens; Siskind; Evans et alin Geophysical Research Letters (2017), 44The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are ... [more ▼]The manuscript describes the observation of Martian mesosphericclouds between 60 and 80 km altitude by the Imaging Ultraviolet Spectrograph (IUVS) on NASA’sMAVEN spacecraft. The cloud observations are uniquely obtained at early morning local times, whichcomplement previous observations obtained primarily later in the diurnal cycle. Differences in thegeographic distribution of the clouds from IUVS observations indicate that the local time is crucial for theinterpretation of mesospheric cloud formation. We also report concurrent observations of upperatmospheric scale heights near 170 km altitude, which are diagnostic of temperature. These observationssuggest that the dynamics enabling the formation of mesospheric clouds propagate all the way to theupper atmosphere. [less ▲]Detailed reference viewed: 16 (3 ULg) Transparent Electrodes Based on Silver Nanowire Networks: From Physical Considerations towards Device IntegrationBellet, Daniel; Lagrange, Mélanie; Sannicolo, Thomas et alin Materials (2017), 10The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells ... [more ▼]The past few years have seen a considerable amount of research devoted to nanostructured transparent conducting materials (TCM), which play a pivotal role in many modern devices such as solar cells, flexible light-emitting devices, touch screens, electromagnetic devices, and flexible transparent thin film heaters. Currently, the most commonly used TCM for such applications (ITO: Indium Tin oxide) suffers from two major drawbacks: brittleness and indium scarcity. Among emerging transparent electrodes, silver nanowire (AgNW) networks appear to be a promising substitute to ITO since such electrically percolating networks exhibit excellent properties with sheet resistance lower than 10 Ω/sq and optical transparency of 90%, fulfilling the requirements of most applications. In addition, AgNW networks also exhibit very good mechanical flexibility. The fabrication of these electrodes involves low-temperature processing steps and scalable methods, thus making them appropriate for future use as low-cost transparent electrodes in flexible electronic devices. This contribution aims to briefly present the main properties of AgNW based transparent electrodes as well as some considerations relating to their efficient integration in devices. The influence of network density, nanowire sizes, and post treatments on the properties of AgNW networks will also be evaluated. In addition to a general overview of AgNW networks, we focus on two important aspects: (i) network instabilities as well as an efficient Atomic Layer Deposition (ALD) coating which clearly enhances AgNW network stability and (ii) modelling to better understand the physical properties of these networks. [less ▲]Detailed reference viewed: 13 (2 ULg) Calibration and testing of wide-field UV instrumentsFrey, Harald; Mende, Stephen; Loicq, Jerôme et alin Journal of Geophysical Research. Space Physics (2017), 122As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations ... [more ▼]As with all optical systems the calibration of wide-field ultraviolet (UV) systems includes three main areas: sensitivity, imaging quality, and imaging capability. The one thing that makes UV calibrations difficult is the need for working in vacuum substantially extending the required time and effort compared to visible systems. In theory a ray tracing and characterization of each individual component of the optical system (mirrors, windows, and grating) should provide the transmission efficiency of the combined system. However, potentially unknown effects (contamination, misalignment, and measurement errors) can make the final error too large and unacceptable for most applications. Therefore, it is desirable to test and measure the optical properties of the whole system in vacuum and compare the overall response to the response of a calibrated photon detector. A proper comparison then allows the quantification of individual sources of uncertainty and ensures that the whole instrument performance is within acceptable tolerances or pinpoints which parts fail to meet requirements. Based on the experience with the IMAGE Spectrographic Imager, the Wide-band Imaging Camera, and the ICON Far Ultraviolet instruments, we discuss the steps and procedures for the proper radiometric sensitivity and passband calibration, spot size, imaging distortions, flatfield, and field of view determination. [less ▲]Detailed reference viewed: 19 (1 ULg) Diversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformaticsDegueldre, Michel; Verdenaud, Marion; Garikoitz, Legarda et alin Toxicon (2017), 130Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top ... [more ▼]Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity. This strategy bypasses the classical approach by combining high-throughput transcriptomics, proteomics and bioinformatics cutting-edge technologies to generate reliable peptide sequences. The strategy employed to generate hundreds of reliable sequences from Conus venoms is deeply described. The study led to the discovery of (i) conotoxins that belong to known pharmacological families targeting various GPCRs or ion-gated channels, and (ii) new families of conotoxins, never described to date. It also focusses on the diversity of genes, sequences, folds, and PTM's provided by such species. [less ▲]Detailed reference viewed: 21 (2 ULg) A Highly Durable RNAi Therapeutic Inhibitor of PCSK9LANCELLOTTI, Patrizio ; Oury, Cécile in New England Journal of Medicine (2017), 376Detailed reference viewed: 19 (2 ULg) Modelling the influence of strain localisation and viscosity on the behaviour of underground drifts drilled in claystonePardoen, Benoît ; Collin, Frédéric in Computers and Geotechnics (2017), 85Detailed reference viewed: 30 (3 ULg) Steel construction - design and research - Special issue associated to the TC11 workshopDemonceau, Jean-François ; Graziano, Leoni; Couchman, Graham et alin Steel Construction (2017), 10Detailed reference viewed: 10 (0 ULg) Première consultation ambulatoire du nouveau-néRIGO, Vincent ; PIELTAIN, Catherine ; Schoffeniels, Colombe et alin Revue Médicale de Liège (2017), 72(5), 253-259The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate ... [more ▼]The focus on outpatient follow-up of newborn infants increases as the duration of hospital stay after birth decreases. The first outpatient visit addresses the adequacy of the home transition. Appropriate feedings are checked. Sudden infant death syndrome prevention and security advices are reminded. Realisation of both neonatal dried blood screen and hearing test is confirmed, as well as planning of specific follow-up appointments. The physical exam will focus on red flags for diseases or malformations with a delayed presentation. [less ▲]Detailed reference viewed: 27 (7 ULg) Régimes matrimoniaux et effets patrimoniaux des partenariats enregistrés en Europe. Propos introductifsWautelet, Patrick in Droit de la famille (2017), 22(5), 10-13Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des ... [more ▼]Ce bref texte présente quelques propos introductifs destinés à situer les règlements 2016/1103 et 2016/1104. Le texte s'attarde sur l'histoire de ces règlements, leur plus-value et esquisse certaines des questions ouvertes qu'ils posent [less ▲]Detailed reference viewed: 58 (2 ULg) The exclusion of competing one-way essential complements: implications for net neutralityBroos, Sébastien ; Gautier, Axel in International Journal of Industrial Organization (2017), 52We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A ... [more ▼]We analyze the incentives of internet service providers (ISPs) to break net neutrality by excluding competing one-way essential complements, i.e. internet applications competing with their own products. A typical example is the exclusion of VoIP applications by telecom companies offering internet and voice services. A monopoly ISP may want to exclude a competing internet app if it is of inferior quality and the ISP cannot ask for a surcharge for its use. Competition between ISPs never leads to full app exclusion but it may lead to a fragmented internet where only one ISP offers the application. We show that, both in monopoly and duopoly, prohibiting the exclusion of the app and surcharges for its use does not always improve welfare. [less ▲]Detailed reference viewed: 82 (19 ULg) Powers, abilities and skills in early modern philosophyBoccaccini, Federico ; Marmodoro, Annain British Journal for the History of Philosophy (2017), 25(3), 1-8Detailed reference viewed: 25 (5 ULg) Unravelling fluvial deposition and pedogenesis in ephemeral stream deposits in the vicinity of the prehistoric rock shelter of Ifri n'Ammar (NE Morocco) during the last 100 kaBartz, Melanie; Rixhon; Kehl, Martin et alin Catena (2017), 152Detailed reference viewed: 37 (7 ULg) Co-creating service recovery after service failure: The role of brand equityHazee, Simon ; Van Vaerenbergh, Yves; Armirotto, Vincentin Journal of Business Research (2017), 74Co-creating service recovery with customers has recently appeared as a new perspective in service research. Prior research demonstrates the effectiveness of co-created recovery strategies in driving ... [more ▼]Co-creating service recovery with customers has recently appeared as a new perspective in service research. Prior research demonstrates the effectiveness of co-created recovery strategies in driving customer outcomes, and out- lines when co-creating a service recovery is recommended. This paper complements prior research not only by demonstrating the mediating role of outcome favorability in the relationship between co-created service recov- ery and customer outcomes, but also by showing whether organizations with different levels of brand equity benefit equally from co-creating service recovery with their customers. The results of two experiments show that co-creating a service recovery makes customers believe they received the most favorable solution for the ser- vice failure, which in turn influences satisfaction with service recovery and repurchase intentions. In addition, co- creating a service recovery is recommended for organizations with low levels of brand equity, but not for orga- nizations with high levels of brand equity. [less ▲]Detailed reference viewed: 64 (5 ULg) Merci à vous!RADERMECKER, Régis in Revue de l'Association Belge du Diabète (2017), 60(3), Detailed reference viewed: 35 (2 ULg) Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometryEchterbille, Julien; Gilles, Nicolas; Araoz, Romulo et alin Toxicon (2017), 130Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]Detailed reference viewed: 30 (6 ULg) Discovery and pharmacological characterization of succinate receptor (SUCNR1/GPR91) agonistsGeubelle, Pierre ; Gilissen, Julie; Dilly, Sebastien et alin British Journal of Pharmacology (2017), 174(9), 796-808Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho ... [more ▼]Background and Purpose The succinate receptor (SUCNR1 or GPR91) has been described as a metabolic sensor that may be involved in homeostasis. Notwithstanding its implication in important (patho)physiological processes, the function of SUCNR1 has remained elusive because no pharmacological tools were available. We report on the discovery of the first family of synthetic potent agonists. Experimental Approach We screened a library of succinate analogues and analysed their activity on SUCNR1. In addition, we modelled a pharmacophore and a binding site for the receptor. New agonists were identified based on the information provided by these two approaches. Their activity was studied in various bioassays, including measurement of cAMP levels, [Ca2+]i mobilisation, TGF-α shedding and recruitment of arrestin 3. The in vivo impact of SUCNR1 activation by these new agonists was evaluated on rat blood pressure. Key Results We identified cis-epoxysuccinic acid and cis-1,2-cyclopropanedicarboxylic acid as agonists with an efficacy similar to the one of succinic acid. Interestingly, cis-epoxysuccinic acid was characterized by a 10 to 20 fold higher potency than succinate on the receptor. For example, cis-epoxysuccinic acid reduced cAMP levels with a pEC50 = 5.57 ± 0.02 (EC50 = 2.7 μM) as compared to succinate pEC50 = 4.54 ± 0.08 (EC50 = 29 μM). The rank order of potency of the three agonists was the same in all bioassays tested. In vivo, cis-epoxysuccinic and cis-1,2-cyclopropanedicarboxylic acid increased rat blood pressure to the same extent as succinate did. Conclusions and Implications We provide new agonist tools for SUCNR1 that should facilitate further research on this understudied receptor. [less ▲]Detailed reference viewed: 41 (6 ULg) Experimental and Numerical Study of Mini-UAV Propeller Performance in Oblique FlowTheys, Bart; Dimitriadis, Grigorios ; Hendrick, Patrick et alin Journal of Aircraft (2017), 54(3), 1076-1084This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow ... [more ▼]This paper presents the modelling of the performance of small propellers used for Vertical Take Off and Landing Micro Aerial Vehicles (VTOL MAVs) operating at low Reynolds numbers and in oblique flow. Blade Element Momentum Theory (BEMT), Vortex Lattice Method (VLM) and momentum theory for oblique flow are used to predict propeller performance. For validation, the predictions for a commonly used propeller for VTOL MAVs are compared to a set of wind tunnel experiments. Both BEMT and VLM succeed in predicting correct trends of the forces and moments acting upon the propeller shaft, although accuracy decreases significantly in oblique flow. For the dataset analysed here, combining the available data of the propeller in purely axial flow with momentum theory for oblique flow and applying a correction factor for the wake skew angle results in more accurate performance estimates at all elevation angles. [less ▲]Detailed reference viewed: 80 (13 ULg) Comparative assessment of 6-[18F]fluoro-L-m-tyrosine and 6-[18F]fluoro-L-dopa to evaluate dopaminergic presynaptic integrity in a Parkinson’s disease rat model.Becker, Guillaume ; Bahri, Mohamed Ali ; Michel, Anne et alin Journal of Neurochemistry (2017), 141Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical ... [more ▼]Because of the progressive loss of nigro-striatal dopaminergic terminals in Parkinson’s disease (PD), in vivo quantitative imaging of dopamine (DA) containing neurons in animal models of PD is of critical importance in the pre-clinical evaluation of highly awaited disease-modifying therapies. Among existing methods, the high sensitivity of positron emission tomography (PET) is attractive to achieve that goal. The aim of this study was to perform a quantitative comparison of brain images obtained in 6-hydroxydopamine (6-OHDA) lesioned rats using two dopaminergic PET radiotracers, namely [18F]fluoro-3,4-dihydroxyphenyl-L-alanine ([18F]FDOPA) and 6-[18F]fluoro-L-m-tyrosine ([18F]FMT). Because the imaging signal is theoretically less contaminated by metabolites, we hypothesized that the latter would show stronger relationship with behavioural and post-mortem measures of striatal dopaminergic deficiency. We used a within-subject design to measure striatal [18F]FMT and [18F]FDOPA uptake in eight partially lesioned, eight fully lesioned and ten sham-treated rats. Animals were pretreated with an L-aromatic amino acid decarboxylase (AADC) inhibitor. A catechol-O-methyl transferase inhibitor was also given before [18F]FDOPA PET. Quantitative estimates of striatal uptake were computed using conventional graphical Patlak method. Striatal dopaminergic deficiencies were measured with apomorphine-induced rotations and post-mortem striatal DA content. We observed a strong relationship between [18F]FMT and [18F]FDOPA estimates of decreased uptake in the denervated striatum using the tissue-derived uptake rate constant Kc. However, only [18F]FMT Kc succeeded to discriminate between the partial and the full 6-OHDA lesion and correlated well with the post-mortem striatal DA content. This study indicates that the [18F]FMT could be more sensitive, with respect of [18F]FDOPA, to investigate DA terminals loss in 6-OHDA rats, and open the way to in vivo AADC activity targeting in future investigations on progressive PD models. [less ▲]Detailed reference viewed: 37 (7 ULg) The internet as a source of information used by women after childbirth to meet their need for information: A web-based survey.Slomian, Justine ; Bruyère, Olivier ; Reginster, Jean-Yves et alin Midwifery (2017), 48OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to ... [more ▼]OBJECTIVE: the aims of this survey were: (a) to evaluate the need of information after childbirth and what questions do 'new' mothers ask themselves; (b) to assess why and how women use the Internet to meet their need of information; (c) to describe how the respondents evaluate the reliability of the information found; (d) to understand how the information found on the Internet affects women's decision-making; and (e) to appreciate how health professionals react to the information found by the women. DESIGN: this study used a large web-based survey that was widely broadcasted on various websites and social networks. SETTING AND PARTICIPANTS: belgian women who had a child under 2 years old and who agreed to participate were included in the study. FINDINGS: 349 questionnaires were valid for analyses. After childbirth, 90.5% of women admitted to using the Internet to seek information about themselves or about their baby, regardless of socioeconomic status or age. There were various reasons for seeking information on the Internet, but the most frequent reason the women expressed was to find information 'on their own' (88.1%). The most searched for topic was breastfeeding. The women believed that the information was quite useful (82.7%) but they assigned an average score of 5.3 out of 10 for the quality of the information they found on the Internet. Approximately 80% of the women felt that the Internet helped them control a decision that they made 'a little', 'often' or 'very often'. Professionals are not always willing to talk about information found on the Internet with mothers. Therefore, many women believed that health professionals should suggest reliable Internet websites for new mothers. CONCLUSIONS: the integration of the Internet and new technologies could be a useful tool during postpartum management. [less ▲]Detailed reference viewed: 20 (7 ULg) Gestion d’un cas de brûlure étendue suite à une chirurgie de convenancePicavet, Pierre ; Jacobs, Morgane ; Noël, Stéphanie et alin Monde Vétérinaire (Le) (2017), 169Detailed reference viewed: 8 (2 ULg) La Cour de cassation face à sa propre faute (obs. sous C.C. 2017/22)Bouhon, Frédéric in Revue de Jurisprudence de Liège, Mons et Bruxelles (2017), 2017/22Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les ... [more ▼]Cet article consiste en un commentaire de l'arrêt n° 29/2017 de la Cour constitutionnelle, lequel apporte des enseignements nouveaux en matière de responsabilité extracontractuelle de l'État pour les dommages engendrés par la faute du juge. Il est question du cas particulier où un justiciable demande au juge du fond de condamner l’État belge à réparer un dommage causé par une faute qu’aurait commise la Cour de cassation. Plus précisément, il apporte une réponse – positive – à la question de savoir si cette haute juridiction peut, dans l’hypothèse où un pourvoi est formé contre la décision du juge du fond, intervenir dans une affaire qui concerne une faute qu’elle a prétendument commise, en influençant, le cas échéant, l’interprétation de la notion de faute appliquée à son propre acte. [less ▲]Detailed reference viewed: 14 (1 ULg) La déficience en hormone lutéinisante: ses conséquences sur la reproductionVALDES SOCIN, Hernan Gonzalo ; potorac, iulia; LIBIOULLE, Cécile et alin Urologic (2017), 13(1), 18-23En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables ... [more ▼]En physiologie de la reproduction, il est bien établi que les hormones glycoprotéiques hypophysaires LH (hormone lutéinisante) et FSH régulent de concert la production de stéroïdes sexuels (indispensables à la virilisation et à la féminisation) ainsi que la gamétogenèse (spermatogenèse chez l’homme et folliculogenèse chez la femme). La sécrétion des gonadotrophines hypophysaires est à son tour stimulée par quelque 1.500 neurones hypothalamiques à GnRH (gonadotrophin releasing hormone) et inhibée par la GnIH (gonadotrophin nhibitory hormone), récemment identifiée (1). En amont de la GnRH, un ensemble de neuropeptides hypothalamiques tels que les kisspeptines, la neuroquinine B, la dinorphine, la leptine, etc., modulent sa sécrétion (Figure 1). Ces neuropeptides intègrent les différents signaux internes et de l’environnement, nécessaires à la puberté et, par la suite, à la reproduction. En corollaire de ces données physiologiques, les patients porteurs de mutations invalidant les gènes de la GnRH, des neuropeptides décrits et de leurs récepteurs souffrent d’un hypogonadisme hypogonadotrope. Ces patients présentent un déficit plus ou moins sévère de la sécrétion combinée de LH et de FSH (2, 3). Il a fallu attendre des observations rares, telles que des mutations de la sous-unité beta (β) de l’hormone lutéinisante, pour comprendre la contribution spécifique et isolée de cette hormone à la reproduction. Dans cet article, nous synthétisons les données historiques et récentes sur la déficience en hormone lutéinisante et ses conséquences sur la reproduction. [less ▲]Detailed reference viewed: 28 (7 ULg) Mild mitochondrial uncoupling induces HSL/ATGL-independent lipolysis relying on a form of autophagy in 3T3-L1 adipocytesDemine, Stéphane; Tejerina, Silvia; Bihin, Benoît et alin Journal of Cellular Physiology (2017)Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet ... [more ▼]Obesity is characterized by an excessive triacylglycerol accumulation in white adipocytes. Various mechanisms allowing the tight regulation of triacylglycerol storage and mobilization by lipid droplet-associated proteins as well as lipolytic enzymes have been identified. Increasing energy expenditure by inducing a mild uncoupling of mitochondria in adipocytes might represent a putative interesting anti-obesity strategy as it reduces the adipose tissue triacylglycerol content (limiting alterations caused by cell hypertrophy) by stimulating lipolysis through yet unknown mechanisms, limiting the adverse effects of adipocyte hypertrophy. Herein, the molecular mechanisms involved in lipolysis induced by a mild uncoupling of mitochondria in white 3T3-L1 adipocytes were characterized. Mitochondrial uncoupling-induced lipolysis was found to be independent from canonical pathways that involve lipolytic enzymes such as HSL and ATGL. Finally, enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles. This new mechanism of triacylglycerol breakdown in adipocytes exposed to mild uncoupling provides new insights on the biology of adipocytes dealing with mitochondria forced to dissipate energy. [less ▲]Detailed reference viewed: 15 (2 ULg) Ultrasonic roll bite measurements in cold rolling: Contact length and strip thicknessCarretta, Yves; Hunter, Andrew; Boman, Romain et alin Proceedings of the Institution of Mechanical Engineers - Part J - Journal of Engineering Tribology (2017)In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip ... [more ▼]In cold rolling of thin metal strip, contact conditions between the work rolls and the strip are of great importance: roll deformations and their effect on strip thickness variation may lead to strip flatness defects and thickness inhomogeneity. To control the process, online process measurements are usually carried out; such as the rolling load, forward slip and strip tensions at each stand. Shape defects of the strip are usually evaluated after the last stand of a rolling mill thanks to a flatness measuring roll. However, none of these measurements is made within the roll bite itself due to the harsh conditions taking place in that area. This paper presents a sensor capable of monitoring strip thickness variations as well as roll bite length in situ and in real time. The sensor emits ultrasonic pulses that reflect from the interface between the roll and the strip. Both the time-of-flight of the pulses and the reflection coefficient (the ratio of the amplitude of the reflected signal to that of the incident signal) are recorded. The sensor system was incorporated into a work roll and tested on a pilot rolling mill. Measurements were taken as steel strips were rolled under several lubrication conditions. Strip thickness variation and roll-bite length obtained from the experimental data agree well with numerical results computed with a cold rolling model in the mixed lubrication regime. [less ▲]Detailed reference viewed: 38 (4 ULg) Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotidesDelierneux, Céline ; Donis, Nathalie ; servais, laurence et alin Journal of Thrombosis and Haemostasis (2017), 15(5), 983-997Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment ... [more ▼]Background: Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (CpG ODNs) display potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicates that CpG ODNs activate human platelets via the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptor glycoprotein VI. Objective: To further analyze the mechanisms of CpG ODN-induced platelet activation and identify potential inhibitory strategies. Methods: In vitro analyses were performed on human and mouse platelets, and on cell lines expressing platelet ITAM receptors. CpG ODN platelet activating effects were evaluated in a mouse model of thrombosis. Results: We demonstrated platelet uptake of CpG ODNs, resulting in platelet activation and aggregation. The C-type lectin-like receptor 2 (CLEC-2) expressed in DT40 cells bound CpG ODNs. CpG ODN uptake did not occur in CLEC-2-deficient mouse platelets. Inhibition of human CLEC-2 with a blocking antibody inhibited CpG ODN-induced platelet aggregation. CpG ODNs caused CLEC-2 dimerization, and provoked its internalization. They induced dense granule release before the onset of aggregation. Accordingly, pretreating platelets with apyrase, or inhibiting P2Y12 with cangrelor or clopidogrel prevented CpG ODN platelet activating effect. In vivo, intravenously injected CpG ODN interacted with platelets adhered to mouse injured endothelium, and promoted thrombus growth, which was inhibited by CLEC-2 deficiency or by clopidogrel. Conclusions: CLEC-2 and P2Y12 are required for CpG ODN-induced platelet activation and thrombosis and might be targeted to prevent adverse events in patients at risk. [less ▲]Detailed reference viewed: 36 (16 ULg) Finite element model reduction for space thermal analysisJacques, Lionel ; Béchet, Eric ; Kerschen, Gaëtan in Finite Elements in Analysis and Design (2017), 127To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on ... [more ▼]To alleviate the computational burden of the nite element method for thermal analyses involving conduction and radiation, this paper proposes an automatic conductive-radiative reduction process based on the clustering of a detailed mesh coming from a structural model for instance. The proposed method leads to a signi cant reduction of the number of radiative exchange factors (REFs) to compute and size of the corresponding matrix. It further keeps accurate conduction information by introducing the concept of physically meaningful super nodes. The REFs between the super nodes are computed through Monte Carlo ray-tracing on the partitioned mesh, preserving the versatility of the method. The resulting conductive-radiative reduced model is solved using standard iterative techniques and the detailed mesh temperatures can be recovered from the super nodes temperatures for further thermo-mechanical analysis. The proposed method is applied to a structural component of the Meteosat Third Generation mission and is benchmarked against ESATAN-TMS, the standard thermal analysis software used in the European aerospace industry. [less ▲]Detailed reference viewed: 42 (5 ULg) Origin of the counterintuitive dynamic charge in the transition metal dichalcogenidesPike, Nicholas ; Van Troeye, Benoit; Dewandre, Antoine et alin Physical Review B (2017), 95Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we ... [more ▼]Despite numerous studies of transition metal dichalcogenides, the diversity of their chemical bonding characteristics and charge transfer is not well understood. Based on density functional theory we investigate their static and dynamic charges. The dynamic charge of the transition metal dichalcogenides with trigonal symmetry are anomalously large, while in their hexagonally symmetric counterparts, we even observe a counterintuitive sign, i.e., the transition metal takes a negative charge, opposite to its static charge. This phenomenon, so far never remarked on or analyzed, is understood by investigating the perturbative response of the system and by investigating the hybridization of the molecular orbitals near the Fermi level. Furthermore, a link is established between the sign of the Born effective charge and the process of π backbonding from organic chemistry. Experiments are proposed to verify the calculated sign of the dynamical charge in these materials. Employing a high-throughput search we also identify other materials that present counterintuitive dynamic charges. [less ▲]Detailed reference viewed: 25 (3 ULg) Eccentric training for tendon healing after lesion: a rat modelKaux, Jean-François ; Libertiaux, Vincent ; Leprince, Pierre et alin American Journal of Sports Medicine (2017), 45(6), 1440-1446BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore ... [more ▼]BACKGROUND:The tendon is a dynamic entity that remodels permanently. Platelet-rich plasma (PRP) injection has been shown to have a beneficial effect on tendon healing after lesion in rats. Furthermore, eccentric exercise seems to improve the mechanical quality of the tendon. HYPOTHESIS:A combination of PRP injection and eccentric training might be more effective than either treatment alone. STUDY DESIGN:Controlled laboratory study. METHODS:Adult male rats were anesthetized, an incision was performed in the middle of their left patellar tendon and an injection of physiological fluid (PF) or homologous PRP was randomly made at the lesion level. The rats were then divided into 2 groups: the eccentric group, undergoing eccentric training 3 times a week, and the untrained group, without any training. Thus, 4 groups were compared. After 5 weeks, the tendons were removed and their ultimate tensile strength and energy were measured. Tendons were frozen for proteomic analyses when all biomechanical tests were completed. Statistical analysis was performed with linear mixed effect models. RESULTS:No significant difference was found between the treatments using PF injection or PRP injection alone. However, the value of the ultimate tensile force at rupture was increased by 4.5 N (108% of control, P = .006) when eccentric training was performed. An intragroup analysis revealed that eccentric training significantly improved the ultimate force values for the PRP group. Proteomic analysis revealed that eccentric training led to an increase in abundance of several cytoskeletal proteins in the PF group, while a decrease in abundance of enzymes of the glycolytic pathway occurred in the PRP treated groups, indicating that this treatment might redirect the exercise-driven metabolic plasticity of the tendon. CONCLUSION: Eccentric training altered the metabolic plasticity of tendon and led to an improvement of injured tendon resistance regardless of the treatment injected (PF or PRP). CLINICAL RELEVANCE:This study demonstrates the necessity of eccentric rehabilitation and training in cases of tendon lesion regardless of the treatment carried out. [less ▲]Detailed reference viewed: 61 (10 ULg) Continental Climate Gradients in North America and Western Eurasia before and after the Closure of the Central American SeawayUtescher, Torsten; Dreist, Andreas; Henrot, Alexandra-Jane et alin Earth and Planetary Science Letters (2017), 472Detailed reference viewed: 7 (1 ULg) Experimental passive flutter suppression using a linear tuned vibration absorberVerstraelen, Edouard ; Habib, Giuseppe ; Kerschen, Gaëtan et alin AIAA Journal (2017), 55(5), 1707-1722The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be ... [more ▼]The current drive for increased efficiency in aeronautic structures such as aircraft, wind turbine blades and helicopter blades often leads to weight reduction. A con- sequence of this tendency can be increased flexibility, which in turn can lead to un- favourable aeroelastic phenomena involving large amplitude oscillations and non- linear effects such as geometric hardening and stall flutter. Vibration mitigation is one of the approaches currently under study for avoiding these phenomena. In the present work, passive vibration mitigation is applied to a nonlinear experimental aeroelastic system by means of a linear tuned vibration absorber. The aeroelastic apparatus is a pitch and flap wing that features a continuously hardening restoring torque in pitch and a linear restoring torque in flap. Extensive analysis of the sys- tem with and without absorber at pre-critical and post-critical airspeeds showed an improvement in flutter speed of around 36%, a suppression of a jump due to stall flutter, and a reduction in LCO amplitude. Mathematical modelling of the exper- imental system is used to demonstrate that optimal flutter delay is achieved when two of the system modes flutter at the same flight condition. Nevertheless, even this optimal absorber quickly loses effectiveness as it is detuned. The wind tunnel mea- surements showed that the tested absorbers were much slower to lose effectiveness than those of the mathematical predictions. [less ▲]Detailed reference viewed: 116 (34 ULg) Testing a general approach to assess the degree of disturbance in tropical forestsSellan, Giacomo; Simini, Filippo; Maritan, Amos et alin Journal of Vegetation Science (2017), 28(3), 459668Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of ... [more ▼]Questions: Is there any theoretical model enabling predictions of the optimal tree size distribution in tropical communities? Can we use such a theoretical framework for quantifying the degree of disturbance? Location: Reserve of Yangambi, northeast region of the Democratic Republic of Congo. Methods: We applied an allometricmodel based on the assumption that a vir- tually undisturbed forest uses all available resources. In this condition, the forest structure (e.g. the tree size distribution) is theoretically predictable fromthe scal- ing of the tree crown with tree height at an individual level. The degree of dis- turbance can be assessed through comparing the slopes of the tree size distribution curves in the observed and predicted conditions. We tested this tool in forest stands subjected to different degrees of disturbance. We inventoried trees >1.3 m in height by measuring the DBH in three plots of 1 ha each, and measured tree height, crownradius and crownlength in a sub-sample of trees. Results: All tree species, independently of the site, shared the same exponents of allometric relationships: tree height vs tree diameter, crown radius vs tree height, crown length vs tree height and consequently crown volume vs tree height, suggesting that similar trajectories of biomass allocation have evolved irrespective of species. The observed tree size distributions appeared to be power laws (excluding the finite size effect) and, as predicted, the slope was steeper in the less disturbed forest (?2.34) compared to the most disturbed (?1.99). The difference in the slope compared to the theoretical fully functional forest (?2.65) represents the metric for assessing the degree of disturbance. Conclusions: We developed a simple tool for operationalizing the concept of ‘disturbance’ in tropical forests. This approach is species-independent, needs minimal theoretical assumptions, the measurement of only a few structural traits and requires a low investment in equipment, time and computer skills. Its simple implementation opens new perspectives for effectively addressing initiatives of forest protection and/or restoration. [less ▲]Detailed reference viewed: 31 (11 ULg) Sustainability Accounting and Control for Smart City - Special Issue - Call for PapersCrutzen, Nathalie ; Van Bockhaven, Jonas; Schaltegger, Stefan et alin sustainability accounting, management and policy journal (2017)Detailed reference viewed: 314 (1 ULg) PRTEE et épicondyliteJanssen, Arnaud; Kaux, Jean-François in Kinésithérapie du Sport Information (2017), (2ème trimestre 2017), 4-7Detailed reference viewed: 21 (2 ULg) Advanced method optimization for volatile aroma profiling of beer using two-dimensional gas chromatography time-of-flight mass spectrometryStefanuto, Pierre-Hugues ; Perrault, Katelynn ; Dubois, Lena et alin Journal of Chromatography. A (2017)The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two ... [more ▼]The complex mixture of volatile organic compounds (VOCs) present in the headspace of Trappist and craft beers was studied to illustrate the efficiency of thermal desorption (TD) comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC × GC-TOFMS) for highlighting subtle differences between highly complex mixtures of VOCs. Headspace solid-phase microextraction (HS-SPME), multiple (and classical) stir bar sorptive extraction (mSBSE), static headspace (SHS), and dynamic headspace (DHS) were compared for the extraction of a set of 21 representative flavor compounds of beer aroma. A Box-Behnken surface response methodology experimental design optimization (DOE) was used for convex hull calculation (Delaunay’s triangulation algorithms) of peak dispersion in the chromatographic space. The predicted value of 0.5 for the ratio between the convex hull and the available space was 10% higher than the experimental value, demonstrating the usefulness of the approach to improve optimization of the GC × GC separation. Chemical variations amongst aligned chromatograms were studied by means of Fisher Ratio (FR) determination and F‐distribution threshold filtration at different significance levels (α = 0.05 and 0.01) and based on z‐score normalized area for data reduction. Statistically significant compounds were highlighted following principal component analysis (PCA) and hierarchical cluster analysis (HCA). The dendrogram structure not only provided clear visual information about similarities between products but also permitted direct identification of the chemicals and their relative weight in clustering. The effective coupling of DHS-TD-GC × GC-TOFMS with PCA and HCA was able to highlight the differences and common typical VOC patterns among 24 samples of different Trappist and selected Canadian craft beers. [less ▲]Detailed reference viewed: 25 (5 ULg) Two-qubit entangling gates between distant atomic qubits in a latticeCesa, Alexandre ; Martin, John in Physical Review A (2017), 95Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two ... [more ▼]Arrays of qubits encoded in the ground-state manifold of neutral atoms trapped in optical (or magnetic) lattices appear to be a promising platform for the realization of a scalable quantum computer. Two-qubit conditional gates between nearest-neighbor qubits in the array can be implemented by exploiting the Rydberg blockade mechanism, as was shown by D. Jaksch et al. [Phys. Rev. Lett. 85, 2208 (2000)]. However, the energy shift due to dipole-dipole interactions causing the blockade falls off rapidly with the interatomic distance, and protocols based on direct Rydberg blockade typically fail to operate between atoms separated by more than one lattice site. In this work, we propose an extension of the protocol of Jaksch et al. for controlled-Z and controlled-NOT gates which works in the general case where the qubits are not nearest neighbors in the array. Our proposal relies on the Rydberg excitation hopping along a chain of ancilla noncoding atoms connecting the qubits on which the gate is to be applied. The dependence of the gate fidelity on the number of ancilla atoms, the blockade strength, and the decay rates of the Rydberg states is investigated. A comparison between our implementation of a distant controlled-NOT gate and one based on a sequence of nearest-neighbor two-qubit gates is also provided. [less ▲]Detailed reference viewed: 40 (7 ULg) Intergroup variation in robbing and bartering by long-tailed macaques at Uluwatu Temple (Bali, Indonesia)Brotcorne, Fany ; Giraud, Gwennan; Gunst, Noelle et alin Primates : Journal of Primatology (2017)Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the ... [more ▼]Robbing and bartering (RB) is a behavioral practice anecdotally reported in free-ranging commensal macaques. It usually occurs in two steps: after taking inedible objects (e.g., glasses) from humans, the macaques appear to use them as tokens, returning them to humans in exchange for food. While extensively studied in captivity, our research is the first to investigate the object/food exchange between humans and primates in a natural setting. During a 4-month study in 2010, we used both focal and event sampling to record 201 RB events in a population of long-tailed macaques (Macaca fascicularis), including four neighboring groups ranging freely around Uluwatu Temple, Bali (Indonesia). In each group, we documented the RB frequency, prevalence and outcome, and tested the underpinning anthropogenic and demographic determinants. In line with the environmental opportunity hypothesis, we found a positive qualitative relation at the group level between time spent in tourist zones and RB frequency or prevalence. For two of the four groups, RB events were significantly more frequent when humans were more present in the environment. We also found qualitative partial support for the male-biased sex ratio hypothesis [i.e., RB was more frequent and prevalent in groups with higher ratios of (sub)adult males], whereas the group density hypothesis was not supported. This preliminary study showed that RB is a spontaneous, customary (in some groups), and enduring population-specific practice characterized by intergroup variation in Balinese macaques. As such, RB is a candidate for a new behavioral tradition in this species. [less ▲]Detailed reference viewed: 24 (7 ULg) Isotopic half-life and enrichment factor in two species of European freshwater fish larvae: an experimental approachLatli, Adrien; Sturaro, Nicolas ; Dujardin, Nelson et alin Rapid Communications in Mass Spectrometry (2017), 31(8), 685-692RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue ... [more ▼]RATIONALE: Stable isotope ratios of carbon and nitrogen are valuable tools for field ecologists to use to analyse animal diets. However, the application of these tools requires knowledge of the tissue enrichment factor (TEF) and half-life (HL). We experimentally compared TEF and HL in two freshwater fish larvae. We hypothesised that chub had a better growth/tissue replacement ratio than roach, due to the use of a food closer to their natural diet. METHODS: We determined the isotopic HL, the TEF and the contribution of growth or metabolic tissue replacement to dynamic isotopic incorporation. After yolk sac resorption, larvae were fed for 5 weeks with prey similar to their natural diet (Artemia nauplii) up to the isotopic equilibrium followed by Chironomid larvae. Stable isotope measurements were carried out using a continuous flow isotope ratio mass spectrometer coupled to an elemental analyser. RESULTS: Changes in isotopic composition strongly followed the predictions of exponential growth and time-dependent models. The isotopic HL varied between 8.2 and 12.6 days and the TEF of nitrogen and carbon ranged from 1.7 to 2.1‰ and from –0.9 to 1.2 ‰, respectively. The incorporation of dietary 13C was due more to the production of new tissue (between 56 and 79%) than to the metabolic process. Chub allocated more energy to growth than roach and the Chironomidae diet contributed more to the consumers’ growth than the Artemia diet. CONCLUSIONS: Metabolic rates seemed lower for chub than for roach, especially when they were fed with Chironomidae. A Chironomidae-based diet would be more profitable to chub, and the high associated growth rate could increase the development of the fish larvae. The HL and TEF were in the range of those reported in the literature. These results will be helpful for field-based studies, because they can help to increase the accuracy of models. [less ▲]Detailed reference viewed: 41 (8 ULg) Effect of growth rate on the physical and mechanical properties of Douglas-fir in Western EuropePolet, Caroline; Henin, Jean-Marc; Hebert, Jacques et alin Canadian Journal of Forest Research = Journal Canadien de la Recherche Forestière (2017), 47To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens ... [more ▼]To quantify the impact of forest management and tree growth rate on the potential uses of Douglas-fir wood, nine physico-mechanical properties were studied on more than 1250 standardized clear specimens. These were collected from trees cut in 11 even-aged stands (6 trees/stand) located in Wallonia (Southern Belgium). Stands were 40 to 69 years old and the mean tree girth was ca. 150 cm. The mean ring width of the 66 trees ranged from 3 to more than 7 mm. Statistical analysis evidenced significant but weak effects of ring width. So, mean ring width and cambial age of the specimens considered jointly only explain 28 to 40% of the variability of the properties studied. From a purely technological standpoint, maintaining mean ring width under 4 mm/year in juvenile wood and 6 mm/year in mature wood should allow all potential uses of Douglas-fir wood. Our results and the literature demonstrate, however, the importance of genetic selection as a complement of silvicultural measures to improve or guarantee the technological properties of Douglas-fir wood. [less ▲]Detailed reference viewed: 13 (1 ULg) Photosensitive polydimethylsiloxane networks for adjustable-patterned filmsJellali, Rachid; Alexandre, Michaël; Jérôme, Christine in Polymer Chemistry (2017), 8(16), 2499-2508Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV ... [more ▼]Polydimethylsiloxanes (PDMSs) bearing photoreactive coumarin groups have been synthesized by amida- tion of a coumarin acid chloride derivative with various amine-functionalized PDMSs. Upon exposure to UV light having a wavelength of above 300 nm, multifunctional coumarin-PDMSs are transformed into covalent networks via [2 + 2] photocycloaddition of two coumarin moieties forming a cyclobutane ring. Taking advantage of the possible localized irradiation through a photomask, a novel concept to generate patterned PDMS films with various surface topologies was demonstrated. This concept is based on the combination of a low molar mass difunctional PDMS with a multifunctional PDMS of a high molar mass forming a photoreversible network allowing osmotic diffusion of a linear PDMS-coumarin of low mole- cular weight in a loosely crosslinked network. Advantageously, illumination by a light source at 254 nm induces the photocleavage of the cyclobutane cross-links offering some photo-induced reversibility to the PDMS network. These novel photo-responsive networks are interesting for several applications, in photo-adaptable biomedical implants (particularly photo-adjustable intra-ocular lenses), photo-tuneable patterned microsystems (e.g. for microfluidics) and photo-switchable controlled release systems. [less ▲]Detailed reference viewed: 33 (5 ULg) X-LAG: How did they grow so tall?BECKERS, Albert ; Rostomyan, Liliya ; Potorac, Iulia et alin Annales d'Endocrinologie (2017)X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset ... [more ▼]X-linked acrogigantism (XLAG) is a new, pediatric-onset genetic syndrome, due to Xq26.3 microduplications encompassing the GPR101 gene. XLAG has a remarkably distinct phenotype with disease onset occurring before the age of 5 in all cases described to date, which is significantly younger than in other forms of pituitary gigantism. These patients have mixed GH and prolactin positive adenomas and/or mixed-cell hyperplasia and highly elevated levels of GH/IGF-1 and prolactin. Given their particularly young age of onset, the significant GH hypersecretion can lead to a phenotype of severe gigantism with very advanced age-specific height Z-scores. If not adequately treated in childhood, this condition results in extreme final adult height. XLAG has a clinical course that is highly similar to some of the tallest people with gigantism in history. « X-linked acrogigantism » (XLAG) est un syndrome pédiatrique récemment décrit, lié à des microduplications du chromosome Xq26.3, englobant le gène GPR101, responsable de l’affection. Les patients XLAG présentent un phénotype remarquablement distinct des autres cas de gigantisme hypophysaire. Dans tous les cas décrits, la maladie s’exprime avant 5 ans soit beaucoup plus tôt que dans les autres formes. Les patients ont habituellement un gros adénome ou une hyperplasie mixte pour la GH et la prolactine et des taux très élevés de GH/IGF1 et prolactine. En raison de son début très précoce, l’hypersécrétion importante de GH peut conduire à un gigantisme extrêmement sévère avec un Z-score très important pour l’âge. Si cette condition n’est pas traitée pendant l’enfance, elle peut conduire à une taille finale extrême. XLAG montre une évolution clinique similaire à celle observée chez les géants les plus grands de l’histoire. [less ▲]Detailed reference viewed: 19 (11 ULg) Pressure flaking to serrate bifacial points for the hunt during the MIS5 at Sibudu Cave (South Africa)Rots, Veerle ; Lentfer, Carol ; Schmid, Viola C. et alin PLoS ONE (2017), 12(4), 0175151Detailed reference viewed: 24 (4 ULg) Reconstructions of the 1900–2015 Greenland ice sheet surface mass balance using the regional climate MAR modelFettweis, Xavier ; Box, Jason; Agosta, Cécile et alin Cryosphere (The) (2017), 11With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional ... [more ▼]With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modèle Atmosphérique Régional; version 3.5.2) model with the ERA-Interim (ECMWF Interim Re-Analysis; 1979–2015), ERA-40 (1958–2001), NCEP–NCARv1 (National Centers for Environmental Prediction–National Center for Atmospheric Research Reanalysis version 1; 1948–2015), NCEP–NCARv2 (1979–2015), JRA-55 (Japanese 55-year Reanalysis; 1958–2014), 20CRv2(c) (Twentieth Century Reanalysis version 2; 1900–2014) and ERA-20C (1900–2010) reanalyses. While all these forcing products are reanalyses that are assumed to represent the same climate, they produce significant differences in the MAR-simulated SMB over their common period. A temperature adjustment of +1 °C (respectively −1 °C) was, for example, needed at the MAR boundaries with ERA-20C (20CRv2) reanalysis, given that ERA-20C (20CRv2) is ∼ 1 °C colder (warmer) than ERA-Interim over Greenland during the period 1980–2010. Comparisons with daily PROMICE (Programme for Monitoring of the Greenland Ice Sheet) near-surface observations support these adjustments. Comparisons with SMB measurements, ice cores and satellite-derived melt extent reveal the most accurate forcing datasets for the simulation of the GrIS SMB to be ERA-Interim and NCEP–NCARv1. However, some biases remain in MAR, suggesting that some improvements are still needed in its cloudiness and radiative schemes as well as in the representation of the bare ice albedo. Results from all MAR simulations indicate that (i) the period 1961–1990, commonly chosen as a stable reference period for Greenland SMB and ice dynamics, is actually a period of anomalously positive SMB (∼ +40 Gt yr−1) compared to 1900–2010; (ii) SMB has decreased significantly after this reference period due to increasing and unprecedented melt reaching the highest rates in the 120-year common period; (iii) before 1960, both ERA-20C and 20CRv2-forced MAR simulations suggest a significant precipitation increase over 1900–1950, but this increase could be the result of an artefact in the reanalyses that are not well-enough constrained by observations during this period and (iv) since the 1980s, snowfall is quite stable after having reached a maximum in the 1970s. These MAR-based SMB and accumulation reconstructions are, however, quite similar to those from Box (2013) after 1930 and confirm that SMB was quite stable from the 1940s to the 1990s. Finally, only the ERA-20C-forced simulation suggests that SMB during the 1920–1930 warm period over Greenland was comparable to the SMB of the 2000s, due to both higher melt and lower precipitation than normal. [less ▲]Detailed reference viewed: 103 (21 ULg) Resolved astrometric orbits of ten O-type binariesLe Bouquin, J.-B.; Sana, H.; Gosset, Eric et alin Astronomy and Astrophysics (2017), 601Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2 ... [more ▼]Our long term aim is to derive model-independent stellar masses and distances for long period massive binaries by combining apparent astrometric orbit with double-lined radial velocity amplitudes (SB2). We follow-up ten O+O binaries with AMBER, PIONIER and GRAVITY at the VLTI. Here, we report about 130 astrometric observations over the last 7 years. We combine this dataset with distance estimates to compute the total mass of the systems. We also compute preliminary individual component masses for the five systems with available SB2 radial velocities. Nine over the ten binaries have their three dimensional orbit well constrained. Four of them are known colliding wind, non-thermal radio emitters, and thus constitute valuable targets for future high angular resolution radio imaging. Two binaries break the correlation between period and eccentricity tentatively observed in previous studies. It suggests either that massive star formation produce a wide range of systems, or that several binary formation mechanisms are at play. Finally, we found that the use of existing SB2 radial velocity amplitudes can lead to unrealistic masses and distances. If not understood, the biases in radial velocity amplitudes will represent an intrinsic limitation for estimating dynamical masses from SB2+interferometry or SB2+Gaia. Nevertheless, our results can be combined with future Gaia astrometry to measure the dynamical masses and distances of the individual components with an accuracy of 5 to 15\%, completely independently of the radial velocities. [less ▲]Detailed reference viewed: 33 (5 ULg) Size and shape variations of the bony components of sperm whale cochleaeSchnitzler, Joseph ; Frederich, Bruno ; Früchtnicht, Sven et alin Scientific Reports (2017), 7Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of ... [more ▼]Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48h after their discovery on German coasts of Schleswig Holstein. The present study aims to explore the morphological variation of the primary sensory organ of sperm whales, the left and right auditory system, using high-resolution computerised tomography imaging. We performed a quantitative analysis of size and shape of cochleae using landmark-based geometric morphometrics to reveal inter-individual anatomical variations. A hierarchical cluster analysis based on thirty-one external morphometric characters classified these 12 individuals in two stranding clusters. A relative amount of shape variation could be attributable to geographical differences among stranding locations and clusters. Our geometric data allowed the discrimination of distinct bachelor schools among sperm whales that stranded on German coasts. We argue that the cochleae are individually shaped, varying greatly in dimensions and that the intra-specific variation observed in the morphology of the cochleae may partially reflect their affiliation to their bachelor school. There are increasing concerns about the impact of noise on cetaceans and describing the auditory periphery of odontocetes is a key conservation issue to further assess the effect of noise pollution. [less ▲]Detailed reference viewed: 14 (3 ULg) Comment on “Hypogonadotrophic hypogonadism due to a mutation in the luteinizing hormone β-subunit gene”VALDES SOCIN, Hernan Gonzalo ; Daly, Adrian ; BECKERS, Albert in Korean Journal of Internal Medicine (The) (2017), 32(3), 566-567Detailed reference viewed: 17 (4 ULg) Organometallic-mediated radical polymerization of 'less activated monomers': fundamentals, challenges and opportunitiesDebuigne, Antoine ; Jérôme, Christine ; Detrembleur, Christophe in Polymer (2017), 115Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the ... [more ▼]Access to well-defined polymers made of the so-called ‘Less Activated Monomers’ (LAMs) via controlled radical polymerization has long been a challenge due to the lack of radical stabilizing group on the double bond of these monomers. This Feature Article summarizes substantial progress in the organometallic-mediated radical polymerization (OMRP) of this important class of monomers including vinyl esters, olefins, vinyl chloride, vinyl amides, or ionic-liquid vinyl monomers. It aims to provide a clear and comprehensive account of the fundamentals and challenges in the OMRP of LAMs as well as an overview of the resulting macromolecular engineering opportunities. The input of photochemistry, environmentally friendly solvents or flow reactors in OMRP is also presented. Finally, it emphasizes how some well-defined LAMs-based materials contributed to the development of specific applications notably in the fields of biomedicine or energy. [less ▲]Detailed reference viewed: 72 (22 ULg) compte rendu de : Greco-Egyptian Interactions. Literature, Translation, and Culture, 500BCE-300 CE. - I. RUTHERFORD ed. - Oxford : Oxford University Press, 2016Rochette, Bruno in Revue des Etudes Anciennes (2017)Detailed reference viewed: 22 (0 ULg) Group B Streptococcus and perinatal mortalityCOOLS, Piet; MELIN, Pierrette in Research in Microbiology (2017), 17The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections ... [more ▼]The World Health Organization estimates that every year, one million neonatal deaths occur because of neonatal infection. Furthermore, an equal number of stillbirths are thought to be caused by infections. Here we discuss the role of Streptococcus agalactiae (group B Streptococcus, GBS) in neonatal disease and stillbirth. [less ▲]Detailed reference viewed: 16 (0 ULg) Vortex Lattice simulations of attached and separated flows around flapping wingsLambert, Thomas ; Abdul Razak, Norizham; Dimitriadis, Grigorios in Aerospace (2017), 4(2), 22Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads ... [more ▼]Flapping flight is an increasingly popular area of research, with applications to micro-unmanned air vehicles and animal flight biomechanics. Fast but accurate methods for predicting the aerodynamic loads acting on flapping wings are of interest for designing such aircraft and optimising thrust production. In this work, the unsteady Vortex Lattice method is used in conjunction with three load estimation techniques in order to predict the aerodynamic lift and drag time histories produced by flapping rectangular wings. The load estimation approaches are the Katz, Joukowski and simplified Leishman-Beddoes techniques. The simulations' predictions are compared to experimental measurements from a flapping and pitching wing presented by Razak and Dimitriadis [1]. Three types of kinematics are investigated, pitch-leading, pure flapping and pitch lagging. It is found that pitch-leading tests can be simulated quite accurately using either the Katz or Joukowski approaches as no measurable flow separation occurs. For the pure flapping tests, the Katz and Joukowski techniques are accurate as long as the static pitch angle is greater than zero. For zero or negative static pitch angles these methods underestimate the amplitude of the drag. The Leishman-Beddoes approach yields better drag amplitudes but can introduce a constant negative drag offset. Finally, for the pitch-lagging tests the Leishman-Beddoes technique is again more representative of the experimental results, as long as flow separation is not too extensive. Considering the complexity of the phenomena involved, in the vast majority of cases the lift time history is predicted with reasonable accuracy. The drag (or thrust) time history is more challenging. [less ▲]Detailed reference viewed: 46 (14 ULg) Bayesian estimation of genetic parameters for individual feed conversion and body weight gain in meat quailDA COSTA CAETANO, GIOVANI; REIS MOTA, Rodrigo ; ALVES DA SILVA, DELVAN et alin Livestock Science (2017), 200We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail ... [more ▼]We estimated genetic correlations between partial and total body weight gain (BWG) and individual feed conversion (FC) aiming to identify possible partial traits as selection criteria in meat quail breeding programs. Data included 379 records from two diﬀerent genetic lines (188 quails from UFV1 and 191 from UFV2). The following traits were evaluated:individual feed conversion from21to28(FC21–28)andfrom28to35daysofage (FC28–35); body weight gain from 1 to 21 (BWG1–21), 21–28 (BWG21–28), 28–35 (BWG28–35) and from 1 to 35 (BWG1–35, full period) days of age. Genetic parameters (heritabilities and genetic correlations) were estimated through multi-trait models via Bayesian inference. For UFV1 line, genetic correlations estimates (with respective credible intervals) between BWG1–21 and BWG1–35, BWG21–28 and BWG1–35, BWG28–35 and BWG1–35, FC21–28 and FC28–35, FC 21–28 and BWG1–35, and FC28–35 and BWG1–35 were 0.62 0.15–0.90), 0.81 0.60–0.94), 0.69 0.35–0.88), 0.06 (−050 to 0.60), −0.87 (−0.97 to −0.63) and −0.51 (−0.84 to −0.01), respectively; and for UFV2 line, these estimates were 0.33 (−0.05 to 0.63), 0.79 0.59–0.92), 0.88 0.73–0.96), 0.35 (−0.30 to 0.78), −0.56 (−0.85 to −0.09) and −0.76 (−0.93 to −0.41), respectively. Additionally, for the UFV1 line heritability estimates for BWG21–28 and FC21–28 were 0.69 0.40–0.86) and 0.55 0.31–0.74), respectively; while for UFV2 line the heritabilities for BWG28–35 and FC28–35 were 0.68 0.47–0.83) and 0.37 0.17–0.63). Based on these results, we recommend as target traits BWG21–28 and FC21–28 for UFV1 line; and BWG28–35 for UFV2 line. Selecting for these indicated traits, we expect to reduce breeding program costs related mainly to feeding of nonselected animals and labor with phenotyping. [less ▲]Detailed reference viewed: 13 (2 ULg) The recent warming trend in North GreenlandOrsi, A.; Kawamura, K.; Masson-Delmotte, V. et alin Geophysical Research Letters (2017)The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric ... [more ▼]The Arctic is among the fastest warming regions on Earth, but it is also one with limited spatial coverage of multi-decadal instrumental surface air temperature measurements. Consequently, atmospheric reanalyses are relatively unconstrained in this region, resulting in a large spread of estimated 30-year recent warming trends, which limits their use to investigate the mechanisms responsible for this trend. Here, we present a surface temperature reconstruction over 1982-2011 at NEEM (51∘ W, 77∘ N), in North Greenland, based on the inversion of borehole temperature and inert gas isotope data. We find that NEEM has warmed by 2.7±0.33∘C over the past 30 years, from the long-term 1900-1970 average of -28.55±0.29∘C. The warming trend is principally caused by an increase in downward longwave heat flux. Atmospheric reanalyses underestimate this trend by 17%, underlining the need for more in situ observations to validate reanalyses. [less ▲]Detailed reference viewed: 33 (4 ULg) L'arrêt de la Cour de cassation du 24 novembre 2016 en matière de funding lossDelforge, Cécile in Chroniques Notariales (2017)Detailed reference viewed: 6 (0 ULg) Scaling Theory of the Anderson Transition in Random Graphs: Ergodicity and UniversalityGarcia-Mata, Ignacio; Giraud, Olivier; Georgeot, Bertrand et alin Physical Review Letters (2017), 118We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that ... [more ▼]We study the Anderson transition on a generic model of random graphs with a tunable branching parameter 1 < K < 2, through large scale numerical simulations and finite-size scaling analysis. We find that a single transition separates a localized phase from an unusual delocalized phase that is ergodic at large scales but strongly nonergodic at smaller scales. In the critical regime, multifractal wave functions are located on a few branches of the graph. Different scaling laws apply on both sides of the transition: a scaling with the linear size of the system on the localized side, and an unusual volumic scaling on the delocalized side. The critical scalings and exponents are independent of the branching parameter, which strongly supports the universality of our results. [less ▲]Detailed reference viewed: 23 (8 ULg) Metabolic inhibitors accentuate the anti-tumoral effect of HDAC5 inhibitionHendrick, Elodie ; Peixoto, Paul; Blomme, Arnaud et alin Oncogene (2017)Detailed reference viewed: 38 (3 ULg) Assessment of bacterial superficial contamination in classical or ritually slaughtered cattle using metagenetics and microbiological analysisKorsak Koulagenko, Nicolas ; Taminiau, Bernard ; Hupperts, Caroline et alin International Journal of Food Microbiology (2017), 247The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological ... [more ▼]The aim of this study was to investigate the influence of the slaughter technique (Halal vs. Classical slaughter) on the superficial contamination of cattle carcasses, by using traditional microbiological procedures and 16S rDNA metagenetics. The purpose was also to investigate the neck area to identify bacteria originating from the digestive or the respiratory tract. Twenty bovine carcasses (10 from each group) were swabbed at the slaughterhouse, where both slaughtering methods are practiced. Two swabbing areas were chosen: one “legal” zone of 1,600 cm2 (composed of zones from rump, flank, brisket and forelimb) and locally on the neck area (200 cm2). Samples were submitted to classical microbiology for aerobic Total Viable Counts (TVC) at 30°C and Enterobacteriaceae counts, while metagenetic analysis was performed on the same samples. The classical microbiological results revealed no significant differences between both slaughtering practices; with values between 3.95 and 4.87 log CFU/100 cm2 and 0.49 and 1.94 log CFU/100 cm2, for TVC and Enterobacteriaceae respectively. Analysis of pyrosequencing data showed that differences in the bacterial population abundance between slaughtering methods were mainly observed in the “legal” swabbing zone compared to the neck area. Bacterial genera belonging to the Actinobacteria phylum were more abundant in the “legal” swabbing zone in “Halal” samples, while Brevibacterium and Corynebacterium were encountered more in “Halal” samples, in all swabbing areas. This was also the case for Firmicutes bacterial populations (families of Aerococcaceae, Planococcaceae). Except for Planococcoceae, the analysis of Operational Taxonomic Unit (OTU) abundances of bacteria from the digestive or respiratory tract revealed no differences between groups. In conclusion, the slaughtering method does not influence the superficial microbiological pattern in terms of specific microbiological markers of the digestive or respiratory tract. However, precise analysis of taxonomy at the genus level taxonomy highlights differences between swabbing areas. Although not clearly proven in this study, differences in hygiene practices used during both slaughtering protocols could explain the differences in contamination between carcasses from both slaughtering groups. [less ▲]Detailed reference viewed: 39 (20 ULg) Use of a metagenetic approach to monitor the bacterial microbiota of “Tomme d’Orchies” cheese during the ripening processCeugniez, Alexandre; Taminiau, Bernard ; Coucheney, Françoise et alin International Journal of Food Microbiology (2017), 247The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade ... [more ▼]The study of microbial ecosystems in artisanal foodstuffs is important to complete in order to unveil its diversity. The number of studies performed on dairy products has increased during the last decade, particularly those performed on milk and cheese derivative products. In this work, we investigated the bacterial content of "Tomme d'Orchies" cheese, an artisanal pressed and uncooked French cheese. To this end, a metagenetic analysis, using Illumina technology, was utilized on samples taken from the surface and core of the cheese at 0, 1, 3, 14 and 21 days of ripening process. In addition to the classical microbiota found in cheese, various strains likely from environmental origin were identified. A large difference between the surface and the core content was observed within samples withdrawn during the ripening process. The main species encountered in the core of the cheese were Lactococcus spp. and Streptococcus spp., with an inversion of this ratio during the ripening process. Less than 2.5% of the whole population was composed of strains issued from environmental origin, as Lactobacillales, Corynebacterium and Brevibacterium. In the core, about 85% of the microbiota was attributed to the starters used for the cheese making. In turn, the microbiota of the surface contained less than 30% of these starters and interestingly displayed more diversity. The predominant genus was Corynebacterium sp., likely originating from the environment. The less abundant microbiota of the surface was composed of Bifidobacteria, Brevibacterium and Micrococcales. To summarize, the “Tomme d’Orchies” cheese displayed a high diversity of bacterial species, especially on the surface, and this diversity is assumed to arise from the production environment and subsequent ripening process. [less ▲]Detailed reference viewed: 33 (8 ULg)