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See detailRate coefficient determination in charge transfer reactions
Vaeck, Nathalie; Baloïtcha, Ezinvy; Desouter, Michèle ULg et al

in International Journal of Molecular Sciences (2002), 3

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See detailAssesment of the situation, three years later, on 'the Belgian Dioxin Crisis'. Probable impact on the health of the Belgian population
Focant, Jean-François ULg; Pirard, Catherine ULg; Douny, Caroline ULg et al

in Annales de Médecine Vétérinaire (2002), 146(6, DEC-JAN), 321-327

In January 1999, Belgium encounters an accidental contamination of the food chain, which was named "the Belgian Dioxin Crisis". The aim of the present review is to estimate the impact of this crisis on ... [more ▼]

In January 1999, Belgium encounters an accidental contamination of the food chain, which was named "the Belgian Dioxin Crisis". The aim of the present review is to estimate the impact of this crisis on public health. Currently, it does not really exist any exhaustive epidemiological study. Various scientific studies actually report somewhat conflicting results. As an example, concerning the population living in Wallonia, recorded dioxin levels are not higher than background levels reported for other industrialized countries, despite the 1999 "dioxin crisis". Conversely, based on levels measured in foodstuffs collected by the end of the crisis period, the dioxin body burden of potential consumers would have increased in the range of 40 to 75 %. The real impact of this crisis on consumers' health could thus only be estimated through well structured epidemiological campaigns. [less ▲]

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See detailDesign of structural joints in building frames
Jaspart, Jean-Pierre ULg

in Progress in Structural Engineering and Materials (2002), 4(1), 18-34

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the ... [more ▼]

A single and unified concept for the design of structural joints in building frames made of any material has been developed in recent years, and is now widely implemented in European design codes. In the present paper, this concept is presented, its merits as far as the economy of a project are demonstrated, and practical design tools for its application in daily practice are briefly described. The paper also contains references to user's manuals and design handbooks. [less ▲]

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See detailA pulsating auroral X-ray hot spot on Jupiter
Gladstone, G. R.; Waite, J. H.; Grodent, Denis ULg et al

in Nature (2002), 415(6875), 1000-1003

Jupiter's X-ray aurora has been thought to be excited by energetic sulphur and oxygen ions precipitating from the inner magnetosphere into the planet's polar regions(1-3). Here we report high-spatial ... [more ▼]

Jupiter's X-ray aurora has been thought to be excited by energetic sulphur and oxygen ions precipitating from the inner magnetosphere into the planet's polar regions(1-3). Here we report high-spatial-resolution observations that demonstrate that most of Jupiter's northern auroral X-rays come from a 'hot spot' located significantly poleward of the latitudes connected to the inner magnetosphere. The hot spot seems to be fixed in magnetic latitude and longitude and occurs in a region where anomalous infrared(4-7) and ultraviolet(8) emissions have also been observed. We infer from the data that the particles that excite the aurora originate in the outer magnetosphere. The hot spot X-rays pulsate with an approximately 45-min period, a period similar to that reported for high-latitude radio and energetic electron bursts observed by near-Jupiter spacecraft(9,10). These results invalidate the idea that jovian auroral X-ray emissions are mainly excited by steady precipitation of energetic heavy ions from the inner magnetosphere. Instead, the X-rays seem to result from currently unexplained processes in the outer magnetosphere that produce highly localized and highly variable emissions over an extremely wide range of wavelengths. [less ▲]

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See detailApproches pharmacologiques de prévention du diabète de type 2.
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (2002), 60

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ... [more ▼]

L’augmentation rapide de la prévalence du diabète de type 2 impose la mise en place de stratégies de prévention. Outre les mesures hygiéno-diététiques, essentielles, diverses approches pharmacologiques ont apporté récemment la preuve d’une certaine efficacité chez les sujets à risque de par la présence d’un excès pondéral et/ou d’une diminution de la tolérance au glucose. C’est le cas de plusieurs antidiabétiques oraux comme la metformine, l’acarbose ou encore la troglitazone. C’est également le cas de médicaments anti-obésité comme l’orlistat et, peut-être aussi, la sibutramine. L’inhibition du système rénine-angiotensine par un inhibiteur de l’enzyme de conversion ou par un antagoniste sélectif des récepteurs AT1 peut aussi, outre protéger contre les complications cardiovasculaires, prévenir l’apparition d’un diabète de type 2. Enfin, le rôle des médicaments hypolipidémiants reste controversé. De nouvelles études prospectives sont en cours pour confirmer ces résultats. [less ▲]

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See detailLe mélange épicéa-douglas, une association intéressante pour le sylviculteur ? 2e partie
Colson, Vincent ULg; Claessens, Hugues ULg; Pauwels, D. et al

in Silva Belgica (2002), 109(4), 25-31

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See detailDifferential pathomechanisms of epidermal necrolytic blistering diseases.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(6), 695-9

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report ... [more ▼]

Staphylococcal scalded skin syndrome (SSSS) results from the effect of exfoliative-toxins produced by staphylococcal strains. The disease affects predominantly children, and is rare in adults. We report two cases of the adult type of SSSS. Corticotherapy, chronic alcohol abuse and epilepsy-related immune changes might have been predisposing factors in these patients. The immunopathological characteristics of the inflammatory cell infiltrate in adults SSSS have not been thoroughly explored so far in the literature. Biopsies from 2 patients with bullous SSSS skin were studied by means of immunochemistry using a panel of 10 antibodies directed to FXIIIa, CD15, CD31, CD45R0, CD50, CD54, CD62E, CD95, CD106, and L1-protein, respectively. Cutaneous biopsies from related blistering diseases were compared. They included drug-induced toxic epidermal necrolysis (TEN), bullous impetigo and superficial pemphigus. A dense cell infiltrate composed of granulocytes (CD15+), macrophages (L1 protein+) and memory T cells (CD45R0+) and a strong expression of ICAM-3 (CD50) were present in the epidermis. CD95+ keratinocytes were lining the intraepidermal blisters. Type I dermal dendrocytes (Factor XIIIa+) were numerous and plump in the dermis. Bullous impetigo exhibited the same pattern of inflammatory cells, but with a lower density in type I dermal dendrocytes. TEN differed from SSSS by both the absence of CD15+ granulocytes and a stronger expression of the pro-apoptotic CD95 antigen in the epidermis. In superficial pemphigus, CD95 antigen was not expressed, and CD15+ granulocytes, CD45R0+ lymphocytes and L1 protein+ monocytes were much less numerous. It is concluded that the specific binding of SSSS-induced exotoxins to the desmosomes alters the keratinocyte metabolism leading to an inflammatory reaction followed by focal apoptosis. Our findings are in line with the concept that SSSS exotoxins might be superantigens. A common pathomechanism leading to epidermal destruction is likely operative in SSSS and bullous impetigo. The inflammatory cell composition in TEN and superficial pemphigus markedly differs from that in SSSS. [less ▲]

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See detailStimulation of matrix metalloproteinase-9 expression in human fibrosarcoma cells by synthetic matrix metalloproteinase inhibitors.
Maquoi, Erik ULg; Munaut, Carine ULg; Colige, Alain ULg et al

in Experimental Cell Research (2002), 275(1), 110-21

Enhanced expression and activation of matrix metalloproteinase-2 (MMP-2) and MMP-9 have been associated with tumor progression, invasion, and metastasis. The use of synthetic MMP inhibitors to block the ... [more ▼]

Enhanced expression and activation of matrix metalloproteinase-2 (MMP-2) and MMP-9 have been associated with tumor progression, invasion, and metastasis. The use of synthetic MMP inhibitors to block the proteolytic activity of these enzymes recently emerged as a potential therapeutic tool to treat cancer. In this study, we report that GI129471, a synthetic broad-spectrum MMP inhibitor, efficiently reduced the in vitro invasiveness of HT1080 cells through type IV collagen, a major component of basement membranes. This reduced invasion was paralleled by a complete inhibition of pro-MMP-2 activation; however, GI129471 strongly increased the amount of secreted pro-MMP-9, which could be subsequently activated through a plasminogen-dependent mechanism. Quantitative RT-PCR and northern blot analysis revealed that GI129471 specifically increased the MMP-9 mRNA steady-state level. Moreover, transient transfection of HT1080 cells with beta-galactosidase reporter vectors containing different lengths of the 5'-flanking region of the MMP-9 gene revealed an upregulation of the transcriptional activity of the corresponding promoter. Well-known modulators of MMP-9 expression such as Il-1beta and TNF-alpha were not involved in this upregulation. These findings emphasize the complexity of the regulation of MMP expression and the requirement for a detailed characterization of the potential adverse side effects associated with the use of broad-spectrum MMPIs. [less ▲]

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See detailFlexihealth : une méthodologie d'évaluation du stress en situation de changement
De Zanet, Fabrice ULg; Vandenberghe, C.; Bossut, Muriel ULg et al

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2002), 39(2), 82-83

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See detailInfiltrative lipoma in the foreleg of a horse
Olle, Edwin; Saunders, Jimmy; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2002), 71

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding ... [more ▼]

This case report describes an infiltrative lipoma in a horse. A slow-growing mass, detected early afterbirth, was present at the caudal aspect of the foreleg (antebrachium) of a 2-year-old gelding. Cytological fea-tures were that of a benign lipoma. Surgical resection was attempted but failed due to the infiltrative natureof the mass. Consequently, the horse was euthanized. Histopathology revealed an infiltrative lipoma. Thistumor is histologically benign but surgical resection is usually impossible due to its infiltrative nature. [less ▲]

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See detailThe role of aminosalicylates in the treatment of ulcerative colitis.
Van Assche, Gert; Baert, Filip; De Reuck, Marc et al

in Acta Gastro-Enterologica Belgica (2002), 65(4), 196-9

Aminosalicylates (5-ASA, sulfasalazine and mesalazine) play a central role in the treatment of ulcerative colitis (UC). For acute treatment of mild to moderate flares and in maintenance treatment, their ... [more ▼]

Aminosalicylates (5-ASA, sulfasalazine and mesalazine) play a central role in the treatment of ulcerative colitis (UC). For acute treatment of mild to moderate flares and in maintenance treatment, their efficacy has been established. Since ulcerative colitis is limited to the distal colon in two thirds of the patients, topical therapy also plays an important role. In mild/moderate active disease 5-ASA 4 g/d is as effective as oral corticosteroids. Ulcerative proctitis is treated with 2 x 500 mg or 1 x 1 g suppositories and proctosigmoiditis with 1 to 4 g enemas. Oral 5-ASA is also safe in maintenance treatment and is generally well tolerated. The risk of colorectal tumours is increased in patients with longstanding ulcerative colitis and epidemiological evidence indicates that chronic 5-ASA treatment reduces this risk. However, at present there is insufficient evidence to maintain patients on life-long 5-ASA maintenance treatment for this indication. [less ▲]

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See detailL'organisation au regard de l'esthétique
Servais, Christine ULg; Heller, Thomas

in Recherches en Communication (2002), 17

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See detailSociété civile et transition. Un regard sur l'évolution du projet de constitution d'une société civile en Roumanie postcommuniste
Pirotte, Gautier ULg

in Transitions : Ex-Revue des Pays de L'est (2002), XLIII(1),

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See detailSociologie de la littérature. La question de l'illégitime
Bertrand, Jean-Pierre ULg; Denis, Benoît ULg

in Lieux Littéraires / La Revue (2002), (5),

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See detailDissociations between categorization and similarity judgements as a result of learning feature distributions
Thibaut, Jean-Pierre; Dupont, Myriam; Anselme, Patrick ULg

in Memory & Cognition (2002), 30(4), 647-656

A dissociation between categorization and similarity was found by Rips (1989). In one experiment, Rips found that a stimulus halfway between a pizza and a quarter was categorized as a pizza but was rated ... [more ▼]

A dissociation between categorization and similarity was found by Rips (1989). In one experiment, Rips found that a stimulus halfway between a pizza and a quarter was categorized as a pizza but was rated as more similar to a quarter. Smith and Sloman (1994) discussed these results in terms of the role of necessary and characteristic features. In two experiments, participants had to learn to categorize novel artificial shapes composed of a nonsalient necessary feature combined with a salient characteristic feature. Participants categorized stimuli on the basis of a necessary feature, whereas their similarity judgments relied on characteristic features. The role of deep (essential) features in dissociations is considered. Results are discussed in terms of the differences between requirements of categorization and similarity judgments. [less ▲]

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See detailCultural characteristics, pathogenicity and vegetative compatibility of Fusarium udum isolates from pigeonpea (Cajanus Cajan (L.) Millsp.) in Kenya
Kiprop, E. K.; Mwang'Ombe, A. W.; Baudoin, Jean-Pierre ULg et al

in European Journal of Plant Pathology (2002), 108(2), 147-154

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See detailA role for the Clostridium perfringens beta 2 toxin in bovine enterotoxaemia?
Manteca, Christophe; Daube, Georges ULg; Jauniaux, Thierry ULg et al

in Veterinary Microbiology (2002), 86(3), 191-202

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and ... [more ▼]

Non-enterotoxigenic type A Clostridium perfringens are associated with bovine enterotoxaemia, but the alpha toxin is not regarded as responsible for the production of typical lesions of necrotic and haemorrhagic enteritis. The purpose of this study was to investigate the putative role of the more recently described beta2 toxin. Seven hundred and fourteen non-enterotoxigenic type A C. perfringens isolated from 133 calves with lesions of enterotoxaemia and high clostridial cell counts (study population) and 386 isolated from a control population of 87 calves were tested by a colony hybridisation assay for the beta2 toxin. Two hundred and eighteen (31%) C perfringens isolated from 83 calves (62%) of the study population and 113 (29%) C. perfringens isolated from 51 calves (59%) of the control population tested positive with the beta2 probe. Pure and mixed cultures of four C perfringens (one alpha+beta2+, one alpha+enterotoxin-1 and two alpha+) were tested in the ligated loop assay in one calf. Macroscopic haemorrhages of the intestinal wall, necrosis and haemorrhages of the intestinal content, and microscopic lesions of necrosis and polymorphonuclear and mononuclear cell infiltration of the intestinal villi were more pronounced in loops inoculated with the a and beta2-toxigenic C. perfringens isolate. These results suggest in vivo synergistic role of the alpha and beta2 toxins in the production of necrotic and haemorrhagic lesions of the small intestine in cases of bovine enterotoxaemia. However, isolation of beta2-toxigenic C. perfringens does not confirm the clinical diagnosis of bovine enterotoxaemia and a clostridial cell counts must still be performed. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detailOn the joint analysis of longitudinal responses and early discontinuation in randomized trials
Vandenhende, François; Lambert, Philippe ULg

in Journal of Biopharmaceutical Statistics (2002), 12

Our focus is on the joint analysis of longitudinal nonnormal responses and early discontinuation in (pre)-clinical trials. Separate models are fitted to the two series (response and discontinuation) to ... [more ▼]

Our focus is on the joint analysis of longitudinal nonnormal responses and early discontinuation in (pre)-clinical trials. Separate models are fitted to the two series (response and discontinuation) to account for covariate and time effects. The serial dependence and the dependence between response and drop-out are also modeled. This is done using particular dependence functions, called copulas. Copulas are used to create a joint distribution with given marginal distributions. Applications are given for the analysis of heart rate/morbidity in toxicology and pain severity/intake of rescue medications in a trial on migraine. Using copulas, the level of dependence between two variables remains invariant to changes in the marginal distribution of either variable. This proves interesting in modeling the association in a longitudinal setting when responses change over time. [less ▲]

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See detailLipid-Interacting Properties Of The N-Terminal Domain Of Human Apolipoprotein C-III
Lins, Laurence ULg; Flore, Christelle ULg; Chapelle, L. et al

in Protein Engineering (2002), 15(6), 513-20

The lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III (apo C-III) were investigated. By molecular modeling, we predicted that the 6-20 fragment of apo C-III is obliquely ... [more ▼]

The lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III (apo C-III) were investigated. By molecular modeling, we predicted that the 6-20 fragment of apo C-III is obliquely orientated at the lipid/water interface owing to an asymmetric distribution of the hydrophobic residues when helical. This is characteristic of 'tilted peptides' originally discovered in viral fusion proteins and later in various proteins including some involved in lipoprotein metabolism. Since most tilted peptides were shown to induce liposome fusion in vitro, the fusogenic capacity of the 6-20 fragment of apo C-III was tested on unilamellar liposomes and compared with the well characterized SIV fusion peptide. Mutants were designed by molecular modeling to assess the role of the hydrophobicity gradient in the fusion. FTIR spectroscopy confirmed the predominantly helical conformation of the peptides in TFE solution and also in lipid-peptide complexes. Lipid-mixing experiments showed that the apo C-III (6-20) peptide is able to increase the fluorescence of a lipophilic fluorescent probe. The vesicle fusion was confirmed by core-mixing and leakage assays. The hydrophobicity gradient plays a key role in the fusion process because the mutant with no hydrophobic asymmetry but the same mean hydrophobicity as the wild type does not induce significant lipid fusion. The apo C-III (6-20) fragment is, however, less fusogenic than the SIV peptide, in agreement with their respective mean hydrophobicity. Since lipid fusion should not be the physiological function of the N-terminal domain of apo CIII, we suggest that its peculiar distribution of hydrophobic residues is important for the lipid-binding properties of apo C-III and should be involved in apolipoprotein and lipid exchanges crucial for triglyceride metabolism. [less ▲]

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See detailRefroidissement de +32°C à +5°C du sperme dilué de taureau de race Borgou au Bénin
Adamou-N'Diaye, M.; Gbangboche, A. B.; Adjovi, A. et al

in Annales des Sciences Agronomiques du Bénin (2002), 3(1), 81-93

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See detailHormonal measurements in late pregnancy and parturition in dairy cows - possible tools to monitor foetal well being
Kornmatitsuk, B.; Veronesi, M. C.; Madej, A. et al

in Animal Reproduction Science (2002), 72(3-4), 153-164

Three dairy heifers (A, B and C) were induced to parturition with two prostaglandin (PG) F-2alpha injections on day 268 and 269 of pregnancy. Signs of approaching parturition were carefully observed. The ... [more ▼]

Three dairy heifers (A, B and C) were induced to parturition with two prostaglandin (PG) F-2alpha injections on day 268 and 269 of pregnancy. Signs of approaching parturition were carefully observed. The following parameters were registered: degrees of calving difficulty, date and time of parturition, calf's birth weight and calf's sex. Body temperature was measured and blood samples were taken every 3 h 3 days before the first PGF(2alpha) injection until 3 days after parturition. The plasma concentrations of the PGF2a metabolite, progesterone, cortisol, oestrone sulphate and pregnancy associated glycoproteins (PAGs) were analysed. Heifers A, B and C delivered 48, 51 and 57 h after the first PGF(2alpha) injection, respectively. Heifer A delivered without any signs of calving difficulty, whereas, the parturition was considered to be slight and moderate difficulty occurred in the delivery of heifers B and C, respectively. The calf of heifer C, without any abnormal gross-evidences, was stillborn. All animals had retained foetal membranes. A slight increase of the PGF(2alpha) metabolite at the time of parturition was found only in heifer C, whereas the levels dramatically increased in all animals 15-24 h after parturition. At the same time, progesterone levels decreased within 3 h after the first PGF(2alpha) injection (P < 0.05) and reached 0.8, 2.7 and 12.4 nmol/l at the time of parturition in heifers A, B and C, respectively. High release of cortisol at the time of parturition was seen in heifer C. Rising levels of oestrone sulphate around the time of parturition were recorded in all heifers, whereas, increasing levels of PAGs were recorded only in heifer A. In conclusion, the patterns of the PGF(2alpha) metabolite, cortisol, progesterone and PAGs were changed in the cases of calving difficulty and stillbirth after PGF(2alpha)-induction of parturition. However, the relationship between oestrone sulphate and PAGs and the status of foetal well being prior to parturition require further elucidation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEvaluation of the Hycel Diagnostics Diana-5 Hematology Analyzer
Boemer, François ULg; Cielniaszek, Nadine; Paulus, Jean-Michel ULg et al

in Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology (2002), 8

The Hycel Diagnostics Diana-5, a compact 5-part differential hematology analyzer, was evaluated in the hematology laboratory of Liège University Hospital, Belgium. Within-and between-batch precision ... [more ▼]

The Hycel Diagnostics Diana-5, a compact 5-part differential hematology analyzer, was evaluated in the hematology laboratory of Liège University Hospital, Belgium. Within-and between-batch precision, linearity, and absence of carryover were all excellent. All parameters were stable for 48 hours at 4 ° C and for 8 hours at room temperature. Comparability of complete blood counts to Bayer Technicon Advia 120 measurements was highly satisfactory, with the exception of the mean cell volume, which was slightly underestimated by the Diana-5 compared to the Advia 120. Comparisons of differential leukocyte counts to 400-cell microscopic differentials were excellent for neutrophils, lymphocytes, and eosinophils and were acceptable for monocytes. The efficiency of the flagging system was high for the detection of blasts and less satisfactory for the detection of immature granulocytes and atypical lymphocytes. The instrument was reliable and easy to use. [less ▲]

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See detailPrévention et traitement des nausées et vomissements après chimiothérapie anticancéreuse
Brasseur, Edmond ULg; Silvestre, Rose-Marie; Jerusalem, Guy ULg et al

in Médecine et Hygiène (2002), 60

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See detailPrediction of carcass lean content by real-time ultrasound in Piétrain and negative stress Piétrain
Youssao, A. K. L.; Verleyen, Vincent ULg; Leroy, Pascal ULg

in Animal Science (2002), 75

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See detailSedimentology, magnetic susceptibility and isotopes of a middle frasnian carbonate platform: Tailfer section, Belgium
Da Silva, Anne-Christine ULg; Boulvain, Frédéric ULg

in Facies (2002), 46

The Tailfer section (Belgium, northern border of the Dinant Synclinorium) exposes Middle Frasnian shallow-water limestones. This paper proposes a sedimentological analysis based on classical petrology ... [more ▼]

The Tailfer section (Belgium, northern border of the Dinant Synclinorium) exposes Middle Frasnian shallow-water limestones. This paper proposes a sedimentological analysis based on classical petrology, which leads to the identification of 19 fourth order sequences, forming three third order system tracts. This sedimentological analyses is complemented by carbon isotopic and magnetic susceptibility (MS) data (based on the relation between MS and lithogenic input). Each system tracts is characterised by a particular evolution of the isotope and MS curve: Biostromal Unit: the biostromes are built by lamellar and branching stromatoporoids and massive metazoans. MS values are weak, in relation with the important distance from landmasses and lesser amounts of lithogenic contribution. The carbon isotope values are close to Frasnian seawater values. Lagoonal Unit: it corresponds to a lagoonal facies succession, from inter- to supratidal zones, rich in Amphipora, paleosiphonocladales, Umbella, and pellets, alternating with paleosoils. MS values are high, related to landmass proximity and high lithogenic input. The carbon isotopic curve shows strongly negative values, close to -7 parts per thousand, resulting probably from a continental influence. Lagoonal and biostromal Unit: it consists of a lagoonal succession with some biostromal interruptions. MS values are lower than in the lagoonal unit and the isotopic values are higher (close to 0 parts per thousand), related to an increase in distality. [less ▲]

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See detailFédéralisme et extrême droite au Royaume-Uni
Jamin, Jérôme ULg

in Fédéralisme - Régionalisme (2002), 2

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See detailLa régulation des services publics: les enseignements du droit comparé
Thirion, Nicolas ULg

in Chroniques de Droit Public = Publiekrechtelijke Kronieken (2002), 4

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See detailComment je traite ... la paralysie faciale par anastomose hypoglosso-faciale.
Courtmans, I; Born, J D; CARLIER, Alain ULg et al

in Revue Médicale de Liège (2002), 57(1), 3-6

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval ... [more ▼]

Thirteen patients underwent a hypoglosso- or a spino-facial nerve anastomosis between 1990 and 1996. Facial palsy was the result of surgery in 12 cases and of radiosurgery in 1 case. The mean interval between facial palsy and anastomosis was 12 months. Facial nerve function is determined on the basis of clinical examination according to the classification of House-Brackmann and our own evaluation. According to House, 10 patients are classified grade III and 3 grade IV. Our evaluation defines in 10 grade III, 7 good results and 3 fair results. As far as the good results are concerned, the mean interval between palsy and anastomosis is short (< 3 months). The permanent eating and swallowing dysfunctions are consecutive to multiple cranial nerve deficits. The post-paralysis hemifacial spasm is facilitated by prolongated electric stimulations. [less ▲]

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See detailSingle step synthesis of metal catalysts supported on porous carbon with controlled texture
Job, Nathalie ULg; Ferauche, fabrice; Pirard, René ULg et al

in Studies in Surface Science and Catalysis (2002), 143

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See detailGestion de l’information dans les pratiques de soins intégrés
Prevost, Marianne; Della Giustina, Vanni; Gosselain, Yves et al

in Santé Conjuguée (2002), 19

Gestion de l’information dans les pratiques de soins intégrés, autrement dit, GIPSI : tel était le thème d’un forum organisé le 15 décembre 2001 à Natoye par la Fédération des maisons médicales, lequel a ... [more ▼]

Gestion de l’information dans les pratiques de soins intégrés, autrement dit, GIPSI : tel était le thème d’un forum organisé le 15 décembre 2001 à Natoye par la Fédération des maisons médicales, lequel a rassemblé une bonne soixantaine de participants issus de trente et une maisons médicales. L’information, c’est un élément clé pour tous les soignants, toutes les équipes : les pratiques de soins reposent sur, et génèrent, une foule d’informations de tous ordres, qu’il n’est pas toujours aisé de rassembler, de trier, d’exploiter à bon escient… comment organiser le recueil et l’analyse de toutes les informations utiles pour améliorer le bien-être des patients – et des soignants ? Quels systèmes d’information peuvent-ils faire gagner du temps, s’intégrer de manière souple dans le travail quotidien, sans poser trop de difficultés nouvelles ? Comment mieux communiquer entre soignants, entre soignants et patients ? Clarifier les questions relatives au partage de l’information, la transmission, la confidentialité ? [less ▲]

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See detailEvaluation of ocean model ventilation with CFC-11: comparison of 13 global ocean models
Dutay, J.-C.; Bullister, J. L.; Doney, S. C. et al

in Ocean Modelling (2002), 4(2), 89-120

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the ... [more ▼]

We compared the 13 models participating in the Ocean Carbon Model Intercomparison Project (OCMIP) with regards to their skill in matching observed distributions of CFC-11. This analysis characterizes the abilities of these models to ventilate the ocean on timescales relevant for anthropogenic CO2 uptake. We found a large range in the modeled global inventory (+/- 30\%), mainly due to differences in ventilation from the high latitudes. In the Southern Ocean, models differ particularly in the longitudinal distribution of the CFC uptake in the intermediate water, whereas the latitudinal distribution is mainly controlled by the subgrid-scale parameterization. Models with isopycnal diffusion and eddy-induced velocity parameterization produce more realistic intermediate water ventilation. Deep and bottom water ventilation also varies substantially between the models. Models coupled to a sea-ice model systematically provide more realistic AABW formation source region; however these same models also largely overestimate AABW ventilation if no specific parameterization of brine rejection during sea-ice formation is included. In the North Pacific Ocean, all models exhibit a systematic large underestimation of the CFC uptake in the thermocline of the subtropical gyre, while no systematic difference toward the observations is found in the subpolar gyre. In the North Atlantic Ocean, the CFC uptake is globally underestimated in subsurface. In the deep ocean, all but the adjoint model, failed to produce the two recently ventilated branches observed in the North Atlantic Deep Water (NADW). Furthermore, simulated transport in the Deep Western Boundary Current (DWBC) is too sluggish in all but the isopycnal model, where it is too rapid. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailDes doutes nes apres le 11 septembre aux espoirs places dans l'euro....
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(1), 1-2

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See detailLes figures féminines dans le théâtre de Jean-Marie Piemme
Delhalle, Nancy ULg

in Alternatives Théâtrales (2002), (75),

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See detailEuclidean and fractal computer-assisted corneofungimetry: a comparison of 2% ketoconazole and 1% terbinafine topical formulations.
Arrese Estrada, Jorge ULg; Fogouang, L.; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(3), 222-7

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups ... [more ▼]

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups of 15 volunteers, corneofungimetry was used to compare the effect of 5-day b.i.d. treatments with 2% ketoconazole and 1% terbinafine creams. METHODS: The bioassay was performed using 10 isolates of each of the 3 fungi Trichophyton rubrum, T. mentagrophytes var. interdigitale and Candida albicans put to grow on human stratum corneum. Controls were stratum corneum either untreated or enriched in propylene glycol contained in an unmedicated vehicle. Quantitative assessments were made using both Euclidean and fractal geometry parameters. RESULTS: In comparison with untreated stratum corneum, the fungitoxic activity of the 2% ketoconazole and 1% terbinafine formulations was obvious and similar against dermatophytes. By contrast, 2% ketoconazole was significantly more active against C. albicans than 1% terbinafine. The propylene-glycol-containing vehicle did not exhibit a significant effect upon the dermatophyte growth. Positive linear correlations were yielded between the extent area and the fractal dimension D of dermatophyte mycelia. By contrast, D appeared unrelated to the relative area of dermatophyte growth compared to controls. CONCLUSION: The combination of Euclidean and fractal analyses improves the information provided by the corneofungimetry bioassay. Creams containing 2% ketoconazole and 1% terbinafine appear equally effective against dermatophytes while the former is more potent against Candida albicans. [less ▲]

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See detailNormative and psychometric data from the Body Image Assessment - Revised in a population of french-speaking women
Bragard, Isabelle ULg; Mayers, I.; Demoulin, Catherine et al

in Psychologica Belgica (2002), 42(4), 227-249

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female ... [more ▼]

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female subjects. They completed questionnaires assessing body experience, eating pathology, psychological functioning, general perception and the BIA-R (Beebe et al., 1999). This test consists of nine silhouettes from which the subject has to choose the somatotype corresponding to her actual shape (cognitive response), the way she feels (affective response) and the way she would like to look (optative response). The results show a good concurrent validity for the cognitive and affective indices and the affective/ cognitive vs. optative divergences. On the other hand, we were not able to demonstrate such validity for the optative index and the affective vs. cognitive divergence index [less ▲]

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See detailWhite-sided dolphin metallothioneins: purification, characterisation and potential role
Das, Krishna ULg; Jacob, Valérie; Bouquegneau, Jean-Marie ULg

in Comparative Biochemistry & Physiology Part C : Toxicology & Pharmacology (2002), 131(3),

Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver ... [more ▼]

Metallothioneins (MTs) were characterised in the kidneys of a white-sided dolphin Lagenorhynchus acutus stranded along the Belgian coast, displaying high levels of cadmium (Cd) and mercury (Hg) in liver and kidney. The protein has two isoforms: MT-1 and MT-2. MT-1 binds Cu, Zn, Hg and Cd, while MT-2 only binds Zn, Hg and Cd. This suggests different metabolic functions for the two isoforms: MT-1 is mainly involved in Cu homeostasis; MT-2, which was fourfold more abundant than MT-1, detoxifies most of the accumulated cadmium. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailQuelques Névroptères d’un site de la région liégeoise (ru de Targnon, Theux, Belgique)
Mignon, Jacques ULg

in Notes Fauniques de Gembloux (2002), 47

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See detailJuvenile acanthosis nigricans and insulin resistance.
Hermanns-Lê, Trinh ULg; Hermanns, Jean-François ULg; Pierard, Gérald ULg

in Pediatric Dermatology (2002), 19(1), 12-4

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be ... [more ▼]

Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be erythematous and pruritic, mimicking an inflammatory dermatitis. Dietary control and oral metformin hydrochloride markedly improved the lesions. Topical calcipotriol may also help to control the skin condition. [less ▲]

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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See detailRepeated intracoronary beta radiation for recurrent in-stent restenosis.
De Benedetti, E; Latchem, D; Roguelov, C et al

in Catheterization and Cardiovascular Interventions (2002), 55(2), 233-236

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only ... [more ▼]

More than 70% of percutaneous coronary interventions are followed by a stent implantation. In-stent restenosis still occurs in 20-30% of patients and remains a therapeutic challenge. At present only vascular brachytherapy has been shown to be an effective treatment option. We report here one case of recurrent in-stent restenosis after vascular brachytherapy that was successfully treated by a second beta radiation treatment. Cathet Cardiovasc Intervent 2002;55:233–236. © 2002 Wiley-Liss, Inc. [less ▲]

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See detailPositron emission tomography (PET) evaluation of abdominal aortic aneurysm (AAA)
SakalihasanN, Natzi ULg; Van Damme, Hendrik ULg; Gomez, P. et al

in European Journal of Vascular and Endovascular Surgery (2002), 23(5), 431-436

Background: aneurysmal disease is associated with all inflammatory Cell infiltrate and enzymatic degradation of the vessel wall. Aim of the study: to detect increased metabolic activity in abdominal ... [more ▼]

Background: aneurysmal disease is associated with all inflammatory Cell infiltrate and enzymatic degradation of the vessel wall. Aim of the study: to detect increased metabolic activity in abdominal aortic aneurysms (AAA) by means of positron emission tomography (PET-imaging). Study design: twenty-six patients with AAA underwent PET-imaging Results: in tell patients, PET-imaging revealed increased, fluoro-deoxy-glucose (18-FDG) uptake at the level of the aneurysm. Patients with positive PET-imaging had one or more of the following elements in their clinical history: history Of recent non-aortic surgery (n = 4) a painful inflammatory aortic aneurysm (n = 2). moderate low back pain (n = 2), rapid (>5 mm in 6 months) expansion (n = 4), discovery by PET-scan of a previously undiagnosed lung cancer (n = 3) or parotid tumour (n = 1). Five patients with a positive PET scan required urgent surgery within two to 30 days. Among the 16 patients with negative PET-imaging of their aneurysm, only one had recent non-aortic surgery, none of them required urgent surgery, only two had a rapidly expanding AAA, and in only one patient, PET-imaging revealed an unknown lung cancer. Conclusion: these data suggest a possible association between increased 18-FDG uptake and AAA expansion and rupture. [less ▲]

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See detailTransient aurora on Jupiter from injections of magnetospheric electrons
Mauk, B. H.; Clarke, J. T.; Grodent, Denis ULg et al

in Nature (2002), 415(6875), 1003-1005

Energetic electrons and ions that are trapped in Earth's magnetosphere can suddenly be accelerated towards the planet(1-5). Some dynamic features of Earth's aurora (the northern and southern lights) are ... [more ▼]

Energetic electrons and ions that are trapped in Earth's magnetosphere can suddenly be accelerated towards the planet(1-5). Some dynamic features of Earth's aurora (the northern and southern lights) are created by the fraction of these injected particles that travels along magnetic field lines and hits the upper atmosphere(4). Jupiter's aurora appears similar to Earth's in some respects; both appear as large ovals circling the poles and both show transient events(6-11). But the magnetospheres of Jupiter and Earth are so different-particularly in the way they are powered-that it is not known whether the magnetospheric drivers(12) of Earth's aurora also cause them on Jupiter. Here we show a direct relationship between Earth-like injections of electrons in Jupiter's magnetosphere and a transient auroral feature in Jupiter's polar region. This relationship is remarkably similar to what happens at Earth, and therefore suggests that despite the large differences between planetary magnetospheres, some processes that generate aurorae are the same throughout the Solar System. [less ▲]

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See detailMicro-organismes pathogènes et viande : la traçabilité alliée de la sécurité.
Daube, Georges ULg

in Extrait du Bulletin de la Société Royale des Sciences de Liège (2002), 1

Meat microbial contamination is frequent in relation to the multiple sources of contamination farm the farm to the fork. These potential hazards must be considered in term of real risk for the consumer ... [more ▼]

Meat microbial contamination is frequent in relation to the multiple sources of contamination farm the farm to the fork. These potential hazards must be considered in term of real risk for the consumer. Thus, each microbiological hazard must be c1assified by scientists by on going probability and by disease gravity. Belgium has developed a high quality surveillance system for the zoonotic agents along the meat production chain. Today, the authorities must make the adequate choices for prevention and communication about these risks. [less ▲]

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See detailCharacterisation of aphid myrosinase and degradation studies of glucosinolates
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Archives of Insect Biochemistry and Physiology (2002), 50(4), 173-182

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification ... [more ▼]

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification. Further FPLC gel filtration gave a single peak at 120 kDa. Denaturing SDS/PAGE of the protein revealed a single band at 60 kDa, indicating that the native B. brassicae myrosinase is a dimer. Kinetic parameters towards 8 glucosinolates were calculated. Strong differences of V-max and Km were observed depending on the substrate. Degradation products of each glucosinolate were identified and quantified by GC-MS and GLC-FID, respectively. Using both crude aphid homogenates and purified myrosinase, two unique hydroxyglucosinolates, 3-butenyl- and benzyl-isothiocyanates were identified from progoitrin ((2S)-2-hydroxybut-3-enyl-glucosinolate) and sinalbin (4-hydroxybenzyl-glucosinolate) degradation respectively. Addition of ascorbic acid to the reaction mixtures containing sinalbin and progoitrin caused the production of hydroxyloted degradation products usually associated with plant myrosinase metabolisation. The occurrence of the myrosinase system in B. brassicae is discussed in terms of similar allelochemical adaptation between the herbivore and its host plant. (C) 2002 Wiley-Liss, Inc. [less ▲]

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See detailEvolution des donnees maternelles et perinatales recueillies en routine entre 1980 et 1998 a la maternite de reference de Rutshuru en Republique democratique du Congo. II. Deces du nouveau-ne et naissances de faible poids.
Mugisho, Etienne; Dramaix, Michele; Porignon, Denis ULg et al

in Sante (Montrouge, France) (2002), 12(2), 252-5

This second paper aims at deriving useful information allowing to improve the strategy applied for maternal health care. MATERIAL AND METHODOLOGY: Between 1980 and 1998, data on 13,042 deliveries were ... [more ▼]

This second paper aims at deriving useful information allowing to improve the strategy applied for maternal health care. MATERIAL AND METHODOLOGY: Between 1980 and 1998, data on 13,042 deliveries were collected. Characteristics, mortality, morbidity of mothers and new-born and obstetrical interventions were recorded. The present work describes the evolution of low birth weight (LBW), new-born deaths, and associated risk factors. The statistical analyses applied included khi2, t-test, and multiple logistic regression. RESULTS: Eighteen percent of new-born weights below 2.5 kg and 7.9% died. The proportion of low birth weights remains globally constant. Low proportions of new-born deaths were observed in 1981, 1982, 1988 and 1998. At admission, 35% of the women presented at least one of the four risks defined by the factors used for reference; this proportion went up from 26.1 to 39.2%. The four reference factors were associated with low birth weight. Baudelocque diameter and age were not associated with new-born death. Education and BMI were associated with an increased risk of new-born death. Marital status was not associated with any of the two outcomes. CONCLUSION: This analysis shows small variation of LBWs and perinatal deaths. It confirms the association between these two outcomes and most of the risk factors studied. The efficacy of the strategies implemented for improving perinatal health is questioned. The authors recommend that they be reassessed. [less ▲]

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See detailDifferential sensitivity of two insect GABA-gated chloride channels to dieldrin, fipronil and picrotoxinin
Le Corronch, Hervé; Alix, Philippe ULg; Hue, B

in Journal of Insect Physiology (2002), 48

In the central nervous system of both vertebrates and invertebrates inhibitory neurotransmission is mainly achieved through activation of gamma-aminobutyric acid (GABA) receptors. Extensive studies have ... [more ▼]

In the central nervous system of both vertebrates and invertebrates inhibitory neurotransmission is mainly achieved through activation of gamma-aminobutyric acid (GABA) receptors. Extensive studies have established the structural and pharmacological properties of vertebrate GABA receptors. Although the vast majority of insect GABA-sensitive responses share some properties with vertebrate GABAA receptors, peculiar pharmacological properties of these receptors led us to think that several GABA-gated chloride channels are present in insects. We describe here the pharmacological properties of two GABA receptor subtypes coupled to a chloride channel on dorsal unpaired median (DUM) neurones of the adult male cockroach. Long applications of GABA induce a large biphasic hyperpolarization, consisting of an initial transient hyperpolarization followed by a slow phase of hyperpolarization that is not quickly desensitized. With GABA, the transient hyperpolarization is sensitive to picrotoxinin, fipronil and dieldrin whereas the slow response is insensitive to these insecticides.When GABA is replaced by muscimol and cis-4-aminocrotonic acid (CACA) a biphasic hyperpolarization consisting of an initial transient hyperpolarization followed by a sustained phase is evoked which is blocked by picrotoxinin and fipronil. Exposure to dieldrin decreases only the early phase of the muscimol and CACA-induced biphasic response, suggesting that two GABA-gated chloride channel receptor subtypes are present in DUM neurones. This study describes, for the first time, a dieldrin resistant component different to the dieldrin- and picrotoxinin-resistant receptor found in several insect species. [less ▲]

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See detailEtalonnage de la figure complexe de Rey sur une population d’enfants de six à douze ans
Garcet, Serge ULg; Deltour, Jean-Jacques; Remacle, Michel

in Revue Scientifique de l'AIGS (2002), 1

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See detailLésion du nerf interosseux postérieur liée à une randonnée prolongée en vélo-tout-terrain (VTT)
Zeevaert, Bernard; CRIELAARD, Jean-Michel ULg; WANG, François-Charles ULg

in Neurophysiologie Clinique = Clinical Neurophysiology (2002)

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See detailGenetic diversity of the african geocarpic legume kersting's groundnut, Macrotyloma geocarpum (Tribe Phaseoleae : Fabaceae)
Pasquet, R. S.; Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg

in Biochemical Systematics & Ecology (2002), 30(10), 943-952

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See detailForests and landscapes – Linking ecology, sustainability and aesthetics (S.R.J. Sheppard, H.W. Harshaw).
Bogaert, Jan ULg

in Landscape & Urban Planning (2002), 59(2), 125-127

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See detailAphid prey suitability as environmental effect on Adalia bipunctata reproduction.
Vanhaelen, Nicolas; Gaspar, Charles ULg; Francis, Frédéric ULg

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 563-8

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding ... [more ▼]

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding stimulants for Brassicaceae specialist insects but are generally repellent and toxic for generalist herbivores. The impact of these compounds on crucifer specialist insects are well known but their effect on generalist predators is still not well documented. Prey host plant influence on reproduction of an aphidophagous beneficial, the two spot ladybird, was determined using the cabbage aphid, Brevicoryne brassicae reared on a crucifer plant, namely Brassica napus containing low GLS levels. As ladybird developmental and reproductive parameters were already shown to be strongly affected by the allelochemical presence in its preys, the unsuitable aphid and host plant combination was only momentary used to feed the A. bipunctata adults. A strong impact of the diet was observed on the beetle fecundity and the emerging offspring. Changing B. brassicae aphid to a suitable prey slowly improved the temporary negative effect of the former diet. These results enhance the food environmental effect and the importance of tritrophic relations in pest management strategies by predators. Indeed, more than the choice of the beneficial species, the prey host plant has a major influence on the potential efficacy of biological agent to control herbivore species such as aphids. [less ▲]

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See detailPaedomorphosis in the Alpine newt (Triturus alpestris): decoupling behavioural and morphological change
Denoël, Mathieu ULg

in Behavioral Ecology and Sociobiology (2002), 52(5), 394-399

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and ... [more ▼]

Paedomorphosis is a heterochronic pattern leading to morphological change, i.e. retention of larval characters in the adult phenotype. The aim of this study was to find out whether behaviour and morphology are decoupled in heterochronic phenotypes. To this end, I compared qualitative and quantitative aspects of courtship behaviour in syntopic metamorphic and paedomorphic Alpine newts, Triturus alpestris. Morphologically, the two morphs differ considerably (e.g. by the presence of gills only in paedomorphs), but their patterns of sexual behaviours are exhibited at similar frequencies and males use the same alternative reproductive tactics to attract unresponsive females. These results show that morphology and behaviour follow different ontogenetic pathways and are thus decoupled. Decoupling of the two traits offers the possibility of morphological evolution without alteration of sexual patterns. [less ▲]

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See detailExpression of TGF-betas and their receptors is differentially modulated by reactive oxygen species and nitric oxide in human articular chondrocytes.
Ayache, N.; Boumediene, K.; Mathy, Marianne ULg et al

in Osteoarthritis and Cartilage (2002), 10(5), 344-52

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS ... [more ▼]

OBJECTIVES: To study the effects exerted by two antioxidants, N-monomethyl-L-arginine (L-NMMA), as an inhibitor of nitric oxide (NO) synthesis, and N-acetylcysteine (NAC), a reactive oxygen species (ROS) scavenger, on the expression of the major growth factor involved in cartilage repair, TGF-beta, under the three isoforms beta1, beta2 and beta3, and the receptors I and II of this factor, using lipopolysaccharide (LPS)-treated human chondrocytes in culture. METHODS: Suspension cultures of human chondrocytes derived from the knee of osteoarthritic patients were treated for 48 h with lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5 mM) or NAC (1 mM). Nitrite levels were assayed on the culture media using the Griess spectrophotometric method. After total RNA extraction, the expression of inducible NO synthase (iNOS), TGF-beta1, TGF-beta2, TGF-beta3, TGF-beta receptors I and II, was determined by semi-quantitative polymerase chain-reaction (RT-PCR). RESULTS: LPS induced a dramatic increase of both NO production and iNOS mRNA level. The addition of L-NMMA (0.5 mM) abolished NO production without affecting iNOS mRNA levels. In contrast NAC (1 mM) strongly synergized with LPS to stimulate NO synthesis. LPS treatment did not significantly alter TGF-beta1 expression whereas L-NMMA inhibited its production. TGF-beta2 mRNA level was decreased by LPS and was not changed in the presence of L-NMMA. On the other hand, NAC was capable of counteracting the LPS-induced inhibition of TGF-beta2 expression. TGFbeta3 mRNA level was markedly reduced by LPS alone, or with both L-NMMA and NAC. Finally, the expression of TGF-betaRI was slightly increased in the presence of combined LPS and L-NMMA or NAC whereas that of TGFbeta-RII was reduced in the same conditions. CONCLUSIONS: The modulation of TGF-beta system was found to be differentially controlled by NO and ROS productions. Indeed, the control exerted on TGF-beta expression varied according to the isoform: TGF-beta1 mRNA level depends on NO whereas that of TGF-beta2 is regulated by ROS and TGF-beta3 seems to be unaffected by both of them. The expression of TGF-beta receptors appeared to be modulated by NO and ROS levels. The relevance of the present findings to osteoarthritis (OA) physiopathology and the potential use of antioxidant therapy to treat this disease are discussed. [less ▲]

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See detailErratum to: “Perturbative evolution and Regge behaviour”: [Phys. Lett. B 448 (1999) 281]
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P.

in Physics Letters B (2002), 528

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See detailCompte rendu de l'ouvrage de D. Giovannangeli : Le retard de la conscience
Cormann, Grégory ULg

in Revue Internationale de Philosophie (2002), 219(1), 144-149

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See detailRegulation by reactive oxygen species of interleukin-1beta, nitric oxide and prostaglandin E(2) production by human chondrocytes.
Mathy, Marianne ULg; Deby, Ginette ULg; Reginster, Jean-Yves ULg et al

in Osteoarthritis and Cartilage (2002), 10(7), 547-55

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2 ... [more ▼]

OBJECTIVES: To determine the effects of two drugs, N-monomethyl-L-arginine (L-NMMA) and N-acetylcysteine (NAC), on interleukin-1beta (IL-1beta), nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by human chondrocytes. The effect of aceclofenac (ACECLO), a non-steroidal antiinflammatory drug (NSAID), was also examined. METHODS: Human chondrocytes were enzymatically isolated from osteoarthritic knee cartilage and then maintained in culture in suspension for 48h in the absence or in the presence of lipopolysaccharide (LPS) (10 microg/ml), L-NMMA (0.5mM), NAC (1mM) or ACECLO (6.10(-6)M). IL-1beta and PGE(2) productions were quantified by specific immunoassays. Nitrite was measured in the culture supernatants by a spectrophotometric method based upon the Griess reaction. Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction. COX-2 protein expression was analysed by Western blot. RESULTS: LPS markedly increased the expression of IL-1beta, iNOS and COX-2 genes. In parallel, NO(2) and PGE(2) amounts found in the culture supernatants were significantly enhanced whereas IL-1beta was immunologically undetectable. The addition of L-NMMA (0.5mM) fully blocked LPS-induced NO production but greatly increased PGE(2) production, suggesting a negative effect of NO on PGE(2) synthesis. Inversely, NO production was stimulated by NAC while PGE(2) production was not affected. Interestingly, NAC increased the IL-1beta and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression. L-NMMA did not significantly affect the expression of IL-1beta, iNOS and COX-2. The amount of COX-2 protein did not change in the presence of the antioxidants. Finally, ACECLO fully blocked the production of PGE(2) by chondrocytes without affecting the levels of COX-2 mRNA. CONCLUSIONS: The stimulation of IL-1beta, NO and PGE(2) production by LPS is differentially controlled by reactive oxygen species (ROS). In fact, L-NMMA and NAC have different mechanisms of action on the regulation of NO and PGE(2) productions. L-NMMA fully inhibits NO but increases PGE(2) production whereas NAC up-regulates NO but does not modify PGE(2) synthesis. The stimulating effect of L-NMMA on PGE(2) production is not controlled at the transcriptional level. These findings suggest that antioxidant therapy could have different effects according to the oxygen radical species targeted. [less ▲]

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See detailMeasurements Of The Horizontal Sprayer Boom Movements By Sensor Data Fusion
Ooms, David ULg; Lebeau, Frédéric ULg; Ruter, R. et al

in Computers and Electronics In Agriculture (2002), 33(2),

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See detailEcological network and local authorities - sociological instrument
Mougenot, Catherine ULg; Roussel, Laurence

in Nature and environment (2002), (126), 37

Ever closer links have been forged between caring for nature on the one hand and human activities on the other. In recent years there has been a shift from an interest in reserve-based nature, which ... [more ▼]

Ever closer links have been forged between caring for nature on the one hand and human activities on the other. In recent years there has been a shift from an interest in reserve-based nature, which excluded man and human activities, to an increasingly powerful nature-culture relationship. Nature protection became nature conservation and then nature development with the integration of socio-economic and cultural aspects. Within the framework of the setting-up of the pan-european ecological network, these sociological aspects have a great importance for establishing an ecological network where the scientific aspects of biodiversity protection must co-exist with nature management and development. [less ▲]

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See detailEvaluation de la composition de la carcasse et de la qualité de la viande par ultrasonographie chez le porc
Youssao, A. K. L.; Verleyen, Vincent ULg; Leroy, Pascal ULg

in Annales de Médecine Vétérinaire (2002), 146(1), 19-29

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See detailChemical changes and influences of rapeseed antinutritional factors on gestating and lactating ewes 1. Animal performances and plasma hormones and glucose
Mandiki, S. N. M.; Derycke, G.; Bister, J. L. et al

in Animal Feed Science & Technology (2002), 98(1-2), 25-35

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating ... [more ▼]

An experiment was carried out in order to study the effects of high levels of low-glucosinolates (LG)-rapeseed meal of two varieties (Apex or Synergy) on ewes and lambs performances and circulating hormones (progesterone-P4, estradiol-E2,-prolactin-PRL, cortisol, insulin, tri-iodothyronin-T3, thyroxin-T4) and glucose. On the 100th day of gestation, 90 ewes bearing at least two foetuses were divided into 3 groups. Control, Apex and Synergy groups received concentrates with 0, 40 and 40% of LG-rapeseed meal obtained with either Apex (13.77 mumol of glucosinolates/g DM seed) or Synergy (18.19 mumol) variety. Apart from the distribution of pasture hay ad libitum, the ewes received 500 and 1200 g of concentrates/animal per day during gestation and lactation, respectively. Concentrates were offered till the 47th day of lactation, and thereafter, the ewes were fed only with hay during 3 weeks. The lambs received ad libitum concentrates without rapeseed meal from 10 days of age till slaughtering. They were weaned at 65 days of age and were slaughtered when their fattening state was optimal. The performances of ewes (food intake and liveweight profiles) and of lambs (birth liveweight, mortality at birth, weight gains, slaughtering parameters) were not reduced by 40% of LG-rapeseed meal except a decrease in the liveweight for ewes in the Apex group after lambing. The profiles and levels of plasma metabolic (T3, T4, cortisol, insulin) and reproductive (PRL, P4) hormones were not modified by the rapeseed meal. In contrast, the estradiol concentration was lower (P < 0.05) in the two groups of ewes which received rapeseed meal than in the controls as an index of an eventual disturbance in the reproductive functions. In conclusion, large amounts of LG-rapeseed meal may be used as protein supplement in the diet of ewes at the end of gestation and during lactation without negative effects on animal performances and physiology. (c( 2002 Published by Elsevier Science B.V. [less ▲]

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See detailDiversité génétique: du diagnostic à la conservation. Le cas du vison d'Europe
Libois, Roland ULg; Michaux, J.; Rosoux, René et al

in Annales de la Société des Sciences Naturelles de la Charente-Maritime (2002), 9(2), 219-223

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See detailEnzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
Fischle, Wolfgang; Dequiedt, Franck ULg; Hendzel, Michael J et al

in Molecular Cell (2002), 9(1), 45-57

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for ... [more ▼]

Histone deacetylases (HDACs) play a key role in regulating eukaryotic gene expression. The HDAC domain, homologous to the yeast repressors RPD3 and HDA1, is considered necessary and sufficient for enzymatic activity. Here, we show that the catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor N-CoR/SMRT. All experimental conditions leading to the suppression of HDAC4 binding to SMRT/N-CoR and to HDAC3 result in the loss of enzymatic activity associated with HDAC4. In vitro reconstitution experiments indicate that HDAC4 and other class II HDACs are inactive in the context of the SMRT/N-CoR-HDAC3 complex and do not contribute to its enzymatic activity. These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity. [less ▲]

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See detailEvidence for a persistent and extensive greening trend in Eurasia inferred from satellite vegetation index data.
Bogaert, Jan ULg; Zhou, L; Tucker, C J et al

in Journal of Geophysical Research (2002), 107(D11),

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See detailBeroepsgeheim, confidentialiteit en de bedrijfsjurist: de nieuwe situatie
Thirion, Nicolas ULg; Benoit-Moury, Anne

in Tijdschrift voor Rechtspersoon en Vennootschap (2002), 1

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See detailLe métabolisme du fer
Beguin, Yves ULg

in Hématologie (2002), 8

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See detailLa nuit et le jour. L'être, l'art, l'autre selon Lévinas
Steinmetz, Rudy ULg

in Voir (2002)

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See detailLe medicament du mois. La rosiglitazone (Avandia).
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(4), 236-9

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma ... [more ▼]

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma) and improve insulin sensitivity. In Belgium as in all European countries, rosiglitazone is indicated for the treatment of type 2 diabetes, only in combination with another antidiabetic oral agent, in patients insufficiently controlled with metformin or a sulphonylurea at a maximal tolerated dose. In these patients, rosiglitazone, at a daily dose of 4 mg (sometimes 8 mg/day with metformin), reduces fasting glycaemia by 2-3 mmol/l and glycated haemoglobin level by about 1%. It exerts also favourable effects on some risk factors related to insulin resistance syndrome, which may contribute to improve cardiovascular prognosis of patients with type 2 diabetes. Hepatic safety of rosiglitazone seems to be good, although it is still recommended to check liver enzymes regularly. As all glitazones, rosiglitazone moderately promotes weight gain. It can also induce some fluid retention which may reveal or aggravate heart failure in at risk patients. [less ▲]

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See detailPhénomènes karstiques fossiles et actuels au sein des formations métamorphiques silico-alumineuses de la nappe pan-africaine de Yaoundé (Sud-Cameroun)
Vicat, Jean-Paul; Mvondoc, Henri; Willems, Luc ULg et al

in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (2002), 334

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non ... [more ▼]

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non-carbonaceous micaschists and gneisses of the Yaoundé Pan-African nappe, south of Cameroon. It is shown that their formation was controlled by the structural features of the rocks. The wells and the pipes in the bedrock outcrops point out a current karstification process, resulting from the plagioclase dissolution by the acid rain waters. Hill wall alveoli and caves, of pre-Miocene age, are exhumed features that were done by dissolution in the aquiferous underground. [less ▲]

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See detailVolumineuse masse pelvienne chez un homme jeune
Andrianne, Robert ULg; Detroz, Bernard ULg; Delbecque, Katty ULg et al

in Revue Médicale de Liège (2002), 57(3), 148-154

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See detailPhylogeny and Morphological Evolution of the Amblystegiaceae (Bryopsida)
Vanderpoorten, Alain ULg; Hedenäs, L.; Cox, C. J. et al

in Molecular Phylogenetics & Evolution (2002), 23

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See detailLa réalité morale du sociologue : le cognitivisme de Raymond Boudon
Jacquemain, Marc ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (2002), 94-95-96

Raymond Boudon defends that the social actor holds overall rational beliefs : we have "good reasons" for most of our beliefs. But he also defends the idea that those "good reasons" can lead to "moral ... [more ▼]

Raymond Boudon defends that the social actor holds overall rational beliefs : we have "good reasons" for most of our beliefs. But he also defends the idea that those "good reasons" can lead to "moral truths". How then can he avoid pure platonism (the idea that "values" exist objectively in a world of their own) ? When confronting to to the task of defending through concrete examples how we can differentiate "good reasons" from bad ones, he says that good reasons are widely shared. But then the idea of objectivity of values dissolves in a loose theory of opinion, that's to say "doxa", which is the very contrary of platonic ideas. So the intent to point to "objective" values seems to lead either to pure dogmatism or to pure relativism. [less ▲]

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See detailComposition de la carcasse, qualité de viande et exploitation du Piétrain stress négatif
Youssao, A. K. L.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Annales de Médecine Vétérinaire (2002), 146(6), 329-338

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See detailReview of present European environmental policies and legislation involving cultural heritage
Teller, Jacques ULg; Bond, Alan

in Environmental Impact Assessment Review (2002), 22

Cultural heritage is being addressed by a number of Charters and Conventions and it is clear that its consideration within decision-making processes is progressively becoming a real challenge, both for ... [more ▼]

Cultural heritage is being addressed by a number of Charters and Conventions and it is clear that its consideration within decision-making processes is progressively becoming a real challenge, both for developers and public authorities. Against this background, this paper reviews the environmental assessment framework developed by the European Community, as this should increasingly influence decision making about cultural heritage in an urban setting. The legislative framework for access to environmental information is also reviewed because of its relevance to the decision-making process. The Directives on Environmental Impact Assessment and Strategic Environmental Assessment both require a consideration of cultural heritage in decision making. This requirement can go some way to addressing the paradox in the European Community’s position whereby the Community wishes to conserve and enhance its own cultural identity whilst, at the same time, cultural heritage is usually defined at a local level. The present paper suggests that, given their flexibility, the two European Community Directives on environmental assessment constitute a promising opportunity to address this seeming paradox, but that there is a significant gap between legal obligations and the methodological tools to meet them. [less ▲]

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See detailTaxonomic assessment, distribution, and ecology of Tortula vahliana var. minor (Pottiaceae, Bryopsida)
Andriessen, L.; Nagels, C.; Arts, T. et al

in Journal of Bryology (2002), 24

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See detailChoice of probing site for estimation of carcass lean percentage in Piétrain pig using the real-time ultrasound
Youssao, A. K. L.; Verleyen, Vincent ULg; Michaux, Charles ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 195-200

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See detailInteraction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane.
Aguedo, Mario ULg; Beney, Laurent; Wache, Yves et al

in International journal of food microbiology (2002), 80(3), 211-5

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological ... [more ▼]

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of gamma-decalactone in microorganisms. [less ▲]

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See detailThree years experiment with the same tin oxide sensor arrays for the identification of malodorous sources in the environment
Romain, Anne-Claude ULg; Nicolas, Jacques ULg; Andre, Philippe ULg

in Sensors and actuators. B, Chemical (2002), (84), 271-277

The paper discusses the ability of recognition models to classify malodours in the environment 3 years after their calibration, with the same sources releasing odours. Two methodologies applicable either ... [more ▼]

The paper discusses the ability of recognition models to classify malodours in the environment 3 years after their calibration, with the same sources releasing odours. Two methodologies applicable either in the lab or in the field are used. The effect of the long term drift of the sensors is highlighted on the results of principal component analysis (PCA) and of discriminant function analysis (DFA). The paper examines also the applicability of some drift counteraction methods proposed in the literature. Handled with some care, a correction based on the drift direction in the principal components subspace should be applicable to the classification of real odorous sources in the field. [less ▲]

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See detailA mixture model to assess the effect of a hormonal stimulation on the development of follicles in prepubertal heifers
Lambert, Philippe ULg

in Journal of the Royal Statistical Society : Series C (Applied Statistics) (2002), 4

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as ... [more ▼]

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as in post-pubertal heifers: after a few days, a dominant follicle arises on one of the two ovaries whereas the other subordinate follicles regress.The dominant follicle remains detectable when the next wave occurs. The number and the diameters of these follicles have been measured for 14 days.The same experiment was repeated after a 3-day FSH stimulation. Several large follicles now arise simultaneously on both ovaries together with small follicles which cannot be detected any more when the next wave occurs. Unfortunately, follicles were not individually tracked. Therefore a three-component mixture model was used to describe the potential simultaneous observation of dominant, decaying dominant and subordinate follicles before the FSH stimulation; the same type of model was considered for large, decaying large and small follicles after the hormonal stimulation. Moreover, for technical reasons, only follicles larger than 2 mm are observable. Measurements were thus left truncated.The models fitted are used to quantify the effects of the stimulation and to determine the ideal time point at which follicles should be punctured under ultrasonography to harvest ovocytes that will be fertilized and cultured in vitro. [less ▲]

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See detailLa prescription des pensions alimentaires: fin d'une controverse. Note sous Cass., 8 décembre 2000
Kohl, Benoît ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2002)

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See detailWalloon Region: An agro-forestry landscape without farmers?
Schmitz, Serge ULg

in Dela (2002), 17

Great landscape diversity of Walloon region, actions for a rural renewal, migratory flows back to rural areas and new challenges of Wallon rural area are presented

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See detailPieges et conseils a propos de l'utilisation des antidiabetiques oraux conventionnels.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 352-6

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of ... [more ▼]

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of severe hypoglycaemic episodes with sulphonylureas and to minimise the risk of lactic acidosis with metformin. These drugs, when used appropriately with respect of contra-indications, have an excellent safety profile and remain the basis of the treatment of type 2 diabetes. [less ▲]

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See detailImage du mois. Une tumeur préauriculaire.
Tassoudji, Nazli ULg; Nikkels, Arjen ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(2), 65-66

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See detailL'etude clinique du mois. La MRC/BHF Heart Protection Study.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 613-6

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily ... [more ▼]

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily or matching placebo. In addition to being randomized to compare simvastatin vs placebo, all patients were also randomized to compare antioxidant vitamin supplementation (vitamin E 600 mg/day, vitamin C 250 mg/day and betacarotene 20 mg/day) vs placebo in a "2 x 2 factorial" design. Duration of the study was 5 years. All-cause mortality was significantly reduced among patients allocated to simvastatin (-12.3%) due to a highly significant (-18%) reduction in the coronary death rate, a marginally significant reduction in other vascular deaths and a non-significant reduction in non-vascular deaths. There were highly significant reductions (of about one-quarter) in the first event rate for non-fatal myocardial infarction and coronary death (combined), for non-fatal and fatal stroke and for coronary or non-coronary revascularization. The beneficial effect of simvastatin was seen in all sub-categories which were studied and, particularly: women vs men; patients aged > 70 years vs those aged < 70 years; patients with LDL cholesterol < vs > 116 mg/dl, or total cholesterol < vs > 193 mg/dl. The treatment was well tolerated and the annual risk of myopathy was 0.01%. All comparisons between antioxidant vitamin supplementation and placebo failed to reveal any difference in favour or against the supplementation which was otherwise well tolerated. These important results and their implications will be briefly discussed. [less ▲]

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See detailLes troubles morpho-syntaxiques développementaux en langage oral : quel cadre théorique adopter?
Maillart, Christelle ULg; Schelstraete, Marie-Anne; Hupet, Michel

in Langage et l'Homme (Le) : Recherches Pluridisciplinaires sur le Langage (2002), 37(2), 85-102

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic ... [more ▼]

This article contrasts two theoretical frames actually used to account for morphosyntactic disorders in children with specific language impairment. The first one stems from a traditional formal linguistic account developped in the context of Chomsky’s works while the second approach, the emergent account, is more functional. Following the linguistic account, it has been assumed that children are born with an innate set of representational constraints, the Universal Grammar, on which grammars are possible for a given language. In contrast, for the emergentist view, it is not necessary to postulate an autonomous device that evolved for grammar rather language in general, and grammar in particular, would emerge from cognitive and communicative abilities and linguistic environment. Both theoretical frames are briefly presented and discussed as well as their implications for the pathology study in children. [less ▲]

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See detailEcueils et chausse-trapes.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 249

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See detailFirst-principles study of the dielectric and dynamical properties of lithium niobate
Veithen, M.; Ghosez, Philippe ULg

in Physical Review. B, Condensed Matter and Materials Physics (2002), 65

Using a first-principles approach based on density-functional theory, the electronic, dielectric, and dynamical properties of the two phases of lithium niobate are studied. In particular, the spontaneous ... [more ▼]

Using a first-principles approach based on density-functional theory, the electronic, dielectric, and dynamical properties of the two phases of lithium niobate are studied. In particular, the spontaneous polarization, the optical dielectric tensors, the Born effective charges, and the zone-center phonons are computed. The Born effective charges are found to be significantly larger than the nominal ionic charges of the ions, a feature similar to what is observed in related ABO(3) compounds and attributed to the hybridization between the O 2p and Nb 4d states. The analysis of the zone-center phonons in the paraelectric phase reveals an unstable A(2u) mode to be responsible for the phase transition. The origin of the structural instability is attributed to destabilizing long-range dipolar interactions, which are not fully compensated by stabilizing short-range forces. Finally, the identification of the E modes in the ferroelectric phase, which is still the cause for debates in spite of the numerous experimental and theoretical studies, is discussed and an assignation based on the analysis of the mode-oscillator strengths and the angular dispersion relation of extraordinary phonons is proposed. [less ▲]

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See detailOn Sally Ledger and Roger Luckhurst’s The Fin de Siècle: A Reader in Cultural History c.1880-1900
Steyaert, Kris ULg

in Journal of Gender Studies (2002), 11(2), 192-193

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See detailDNA immunisation. New histochemical and morphometric data.
Ehirchiou, D.; Zorzi, Willy ULg; Biemans, R. et al

in European Journal of Histochemistry (2002), 46(3), 215-22

Splenic germinal center reactions were measured during primary response to a plasmidic DNA intramuscular injection. Cardiotoxin-pretreated Balb/c mice were immunized with DNA plasmids encodmg or not the ... [more ▼]

Splenic germinal center reactions were measured during primary response to a plasmidic DNA intramuscular injection. Cardiotoxin-pretreated Balb/c mice were immunized with DNA plasmids encodmg or not the SAG1 protein, a membrane antigen of Toxoplasma gondii. Specific anti-SAG1 antibodies were detected on days 16 and 36 after injection of coding plasmids. The results of ELISAs showed that the SAG1-specific antibodies are of the IgG2a class. Morphometric analyses were done on serial immunostained cryosections of spleen and draining or non-draining lymph nodes. This new approach made it possible to evaluate the chronological changes induced by DNA immunisation in the germinal centres (in number and in size). Significant increases in the number of germinal centres were measured in the spleen and only in draining lymph nodes after plasmid injection, the measured changes of the germinal centers appeared to result from the adjuvant stimulatory effect of the plasmidic DNA since both the coding and the noncoding plasmid DNA induced them. No measurable changes were recorded in the T-dependent zone of lymph organs. [less ▲]

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See detailL'Etat social face aux nouvelles attentes compassionnelles. Le cas de la Belgique
Vrancken, Didier ULg

in Nouvelles Pratiques Sociales (2002), 15(2), 53-65

S’intéressant aux grandes mobilisations émotionnelles de ces dernières années en Europe et plus particulièrement en Belgique, cet article propose d’envisager leurs effets sur la structuration de l’Etat ... [more ▼]

S’intéressant aux grandes mobilisations émotionnelles de ces dernières années en Europe et plus particulièrement en Belgique, cet article propose d’envisager leurs effets sur la structuration de l’Etat social. A partir de l’expérience belge, il montre que celles-ci n’ont pas contribué à un renouvellement des formes de participation politique mais se sont plutôt inscrites dans un profond mouvement de moralisation de l’action publique annonçant de nouveaux modes de prise en charge des citoyens davantage ancrés sur des notions telles que la procéduralisation, le territoire, l’accompagnement, la subjectivation et l’aide aux personnes [less ▲]

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