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See detailDeciphering the impaired cytokine cascades in chronic leg ulcers (review).
Quatresooz, Pascale ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in International Journal of Molecular Medicine (2003), 11(4), 411-8

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis ... [more ▼]

Chronic leg ulcers are typically wounds that do not heal at a normal rate. Impaired healing appears to be due to primary microvascular changes and it is aggravated by ongoing bacteria-driven vasculitis. The various cytokines identified in experimental wounds are also present in leg ulcers. VEGF is strongly implicated as a promoter of blood vessel growth in patients with venous disease. In addition, there is good evidence of increased expression of bFGF, TGF-beta1, and PDGF in lipodermatosclerosis. All of these growth factors are involved in wound healing. Upregulated TGF-beta1 is probably one of the main causes of the fibrosis observed in lipodermatosclerosis. In leg ulcers, cytokines appear to be trapped in the perivascular fibrinoid deposits. It is not the nature and amount of cytokines that are inadequate in leg ulcers, but rather their spatial distribution. Dermal dendrocytes (DD) are resident factor XIIIa-enriched macrophages. They likely play a role in tissue repair when boosted adequately. New therapies aiming at helping the release of cytokines by DD apparently promote and improve the healing phase. [less ▲]

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See detailLe cas clinique du mois. Masse médiastinale antérieure chez une patiente acromégale.
Laret, Vinciane ULiege; Valdes Socin, Hernan Gonzalo ULiege; Betea, Daniela ULiege et al

in Revue Médicale de Liège (2003), 58(12), 724-728

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the ... [more ▼]

The discovery of an anterior asymptomatic mediastinal mass with acromegaly creates a dilemma for the clinician. As acromegaly can be due to a pituitary tumor but also to an ectopic production of GHRH, the first diagnostic step consists of finding the etiology of the disease in order to use adequate treatment. This can be complicated by the fact that acromegaly can be associated with other tumors (for instance in MEN-1 disease and Carney Complex) and because chronic GH hypersecretion can stimulate tumor overgrowth and perhaps tumor formation. We describe the case of a 44-year-old acromegalic woman with an anterior mediastinal mass. We present the different diagnoses and a review of the literature. [less ▲]

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See detailThe emotional content of material and reality monitoring function in subjects predisposed towards hallucinations
Laroi, Frank ULiege; Marczewski, P.; Van der Linden, Martial ULiege et al

in Brain and Cognition (2003), 51

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See detailThe family systems approach to treating families of persons with brain injury: a potential collaboration between family therapist and brain injury professional
Laroi, Frank ULiege

in Brain Injury (2003), 17

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a ... [more ▼]

Although brain injury may have a great impact on the family as a whole, family reactions are not adequately addressed in rehabilitative programmes. When they are, treatment tends to be approached from a family education and support perspective and not from a family therapy perspective. The aim of the following paper is to illustrate the important role that a family systems approach can play in treating families of individuals with brain injury. In particular, clinical examples taken from the literature will be presented that illustrate how family roles can be modified as a consequence of a brain injury, and the importance of re-establishing or re-distributing these roles. It will be argued that an intimate collaboration between family therapist and brain injury professional is essential, and that the ideal professional make-up of clinicians working with families of persons with brain injury are those well-versed in both brain injury rehabilitation and family therapy. [less ▲]

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See detailLe Gigantisme : Un mystère élucidé
Beckers, Albert ULiege

in Revue Roumaine d'Endocrinologie (2003), 2(4), 88-9394-97

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See detailModèle de croissance pour les plantations de mélèzes.
Pauwels, D.; Lejeune, Philippe ULiege; Rondeux, Jacques ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 87-97

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches ... [more ▼]

A distance independent tree growth model has been determined for pure and even-aged larch stands (Larix sp.) growing in Walloon Region (South Belgium). This model has been built from 2578 larches (Japanese, European and Hybrid larches) in 99 stands. It enables to predict tree circumference increment from circumference, dominant height, basal area, age and site index of stands. Estimating increments of 1283 larches in 48 stands has been used to validate the model that gives unbiased estimates of the increments (mean error = -0.002 cm with standard deviation of 0.60 cm). The mean absolute error of estimates is 0.46 cm.year-1. The model has also been tested to predict the increment of larches in French experimental plots having very different silvicultural treatments. The residues of these estimations depend on the stand basal area: the lesser the stand basal area, the higher the residues of the estimation. A correction factor, linked to basal area through a Bailey and Clutter curve, has been introduced to extend the validity of the model to stands with a basal area lower than 12 m2.ha-1. This factor does not affect the increment estimations if the stand characteristics are close to mean value of the sample used to build the model (correction factor close to 1). The introduction in the model of competition indexes distance dependant or site qualitative variables does not significantly improve the growth model. [less ▲]

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; Portetelle, Daniel ULiege et al

in Yeast (Chichester, England) (2003), 20(S1),

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See detailThe activation of birdsong by testosterone - Multiple sites of action and role of ascending catecholamine projections
Ball, G. F.; Castelino, C. B.; Maney, D. L. et al

in Annals of the New York Academy of Sciences (2003), 1007

Birdsong is a species-typical stereotypic vocalization produced in the context of reproduction and aggression. Among temperate-zone songbirds, it is produced primarily by males, and its frequency and ... [more ▼]

Birdsong is a species-typical stereotypic vocalization produced in the context of reproduction and aggression. Among temperate-zone songbirds, it is produced primarily by males, and its frequency and quality are enhanced by the presence of the gonadal steroid hormone testosterone in the plasma. In the brain, the effects of testosterone on song behavior involve both estrogenic and androgenic metabolites of testosterone that are locally produced and act via their cognate receptors. Androgen, and in some cases estrogen, receptors are present in many specialized forebrain song control nuclei. Testosterone can regulate catecholamine steady-state levels and turnover in these song control regions. Tracing studies combined with immunocytochemistry for tyrosine hydroxylase (a marker of catecholamine synthesis) reveal several catecholamine cell groups that project to forebrain song control nuclei. These brain areas also express the mRNA for either androgen receptors or estrogen receptor alpha, and androgens enhance the expression of tyrosine hydroxylase. Dopaminergic cell groups that project to song nuclei express the protein product of the immediate early gene fos in association with the production of territorial song. Thus, testosterone may be acting on song behavior via these ascending catecholamine cell groups. Chemical lesioning studies suggest that noradrenergic projections to the song system are involved in the latency to produce song and the ability to discriminate conspecific from heterospecific song. The song control circuit may thus be modulated in significant ways via the androgen regulation of forebrain catecholamine systems. [less ▲]

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Yeast (2003), 20(S291),

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See detailPopulation Genetic Structure Of Wild Phaseolus Lunatus (Fabaceae), With Special Reference To Population Sizes
Zoro Bi, I.; Maquet, A.; Baudoin, Jean-Pierre ULiege

in American Journal of Botany (2003), 90(6), 897-904

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See detailLa géographie humaine et ses revues « internationales » : globalisation ou fragmentation
Schmitz, Serge ULiege

in Annales de Géographie (2003), 112(632), 402-411

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See detailEmile Adan en de introductie van reisinstructies voor de Belgische wetenschappelijke exploratie in Midden-Afrika.
Vandersmissen, Jan ULiege

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 74(1-4), 205-217

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See detailPetit rappel concernant le cacul de la prescription de l'action publique en matière de moeurs
Monville, Pierre ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailLe délai de prescription de l'action civile résultant d'une infraction : fin d'une controverse
Monville, Pierre ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailPatterns Of Bryophyte Diversity And Rarity At A Regional Scale
Vanderpoorten, Alain ULiege; Engels, Patrick ULiege

in Biodiversity & Conservation (2003), 12(3),

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See detailPhylogeny
Baudoin, Jean-Pierre ULiege; Maquet, A.

in Plant and Soil (2003), 252(1), 55-128

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See detailLe mandat d'arrêt européen : remise en cause du mécanisme de simple remise.
Monville, Pierre ULiege

in Journal des Tribunaux Droit Européen (2003)

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See detailZur diatopischen Gliederung des alltagssprachlichen Wortgebrauchs
Möller, Robert ULiege

in Zeitschrift für Dialektologie und Linguistik (2003), 70

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See detailExpression in an msb3msb4 yeast mutant of 2 human homologues of the yeast MSB3 MSB4 genes: RN-tre and Tre2 oncogene
Bizimungu, Christelle; Burny, Arsène; De Nève, Nancy et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients.
Valdes Socin, Hernan Gonzalo ULiege; Chanson, Philippe; Delemer, B. et al

in European Journal of Endocrinology (2003), 148(4), 433-442

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 ... [more ▼]

OBJECTIVE: Our aim was to report the recent changes in diagnosis and management of TSH-secreting pituitary adenomas. METHODS: We retrieved 43 consecutive patients with TSH-secreting pituitary tumors (23 male and 20 female) among 4400 pituitary adenomas followed between 1976 and 2001 in six Belgian and French centers. RESULTS: TSH was elevated in 18/43 and alpha subunit in 13/32 patients. In patients with intact thyroid (n=30), mean free tri-iodothyronine was 13.1 pmol/l (range 3.5-23) and mean free thyroxine was 38.4 pmol/l (range 10.2-62.7). Hyperprolactinemia and acromegaly were associated in 9/43 and 8/43 cases. The number of associated hypersecretions was higher in macroadenomas than in microadenomas (Chi square = 11.2, P<0.01). Two women had sporadic multiple endocrine neoplasia type 1-associated syndrome. The proportion of microadenomas versus macroadenomas was 1/11 (period 1974-1986) and 8/32 (period 1987-2001). Bilateral petrosal sinus sampling, (111)In-pentreotide scintigraphy and ((11)C)-l-methionine positron emission tomography scan confirmed diagnosis in four questionable microadenomas. Macroadenomas with extrasellar extension (31 cases) had a tendency to be medially located. Medical treatment with somatostatin analogs was initiated as first-line treatment in 26 patients. TSH levels were reduced by more than 50% in 23/26 cases. A tumoral shrinkage of more than 20% was observed in 5/13 cases. Surgery was performed in 36 patients. After 1 year, 21 of them (58.3%) met the criteria of surgical favorable outcome. Pituitary radiotherapy (n=8) and somatostatin analogs allowed normalization in cases not cured by surgery. CONCLUSION: Ultrasensitive methods for TSH measurement led to an earlier recognition of TSH-secreting pituitary tumors. In this series, we observed that TSH-secreting pituitary tumors are today more frequently found at the stage of microadenomas, medially located, without associated hypersecretions and needing new exploration methods as compared with older series. This changing spectrum in the presentation of TSH-secreting pituitary tumors and the excellent response to somatostatin analogs has been accompanied by an improvement in the prognosis of the disease. [less ▲]

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See detailRegarder la peau pour convaincre des risques du tabagisme et aider à les prévenir.
Requier, Colette ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2003), 58(6), 439-42

The negative impact of nicotinism on health is evident. Several effects are also recognized on the skin and oral mucosa. The physiopathological alterations depend on the composition of the tobacco leaves ... [more ▼]

The negative impact of nicotinism on health is evident. Several effects are also recognized on the skin and oral mucosa. The physiopathological alterations depend on the composition of the tobacco leaves, tobacco manufacture and modalities of use. The evolution of some dermatoses can be influenced by nicotinism. [less ▲]

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See detailProbing the stereoselectivity of the ruthenium-catalyzed ring-opening metathesis polymerization of norbornene and norbornadiene diesters
Delaude, Lionel ULiege; Demonceau, Albert ULiege; Noels, Alfred ULiege

in Macromolecules (2003), 36(5), 1446-1456

The ring-opening metathesis polymerization (ROMP) of two optically active 2,3-dicarboalkoxynorbornadienes derived from (S)-(-)-2-methyl-1-butanol and (R)-(-)-2-butanol were carried out in the presence of ... [more ▼]

The ring-opening metathesis polymerization (ROMP) of two optically active 2,3-dicarboalkoxynorbornadienes derived from (S)-(-)-2-methyl-1-butanol and (R)-(-)-2-butanol were carried out in the presence of the [RuCl2(P-cymene)](2) catalyst precursor activated by trimethylsilyldiazomethane (TMSD). H-1 and C-13 NMR analyses showed that a high degree of stereoregularity was achieved, and homonuclear proton-proton COSY spectroscopy indicated that the major trans fractions of the polymers were most likely isotactic, while the minor cis fractions were syndiotactic. Ring-opened metathesis polymers were also made from 2,3-dicarbomethoxynorbornadiene and exo,exo-2,3-dicarbomethoxy-5-norbornene. They were hydrogenated into the corresponding polynorbornanes using diimide. The NMR spectra of the reduced materials confirmed that the unsaturated parent polymers had an all-trans highly isotactic microstructure. A tentative mechanism involving arene loss, carbene formation, and monomer chelation is proposed to account for the observed stereoselectivities. [less ▲]

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See detailCantari novellistici dal Tre al Cinquecento
Moreno, Paola ULiege

in Moyen Age (Le) (2003)

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See detailPreschoolers' use of form class cues to learn descriptive proper names
Hall, D. G.; Waxman, S. R.; Brédart, Serge ULiege et al

in Child Development (2003), 74(5), 1547-1560

This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an ... [more ▼]

This study examined 3- and 4-year-old preschoolers' ability to learn proper names containing familiar descriptions. Children saw a novel creature with a familiar property (it was red) and heard either an adjective ("This is a red one") or a descriptive proper name ("This is Mr. Red"). The creature was then transformed, losing the property (e.g., it became green). Children had to extend the word to either the transformed original creature or a new creature bearing the original property (another red creature). Children, especially 4-year-olds, extended the adjective to the new creature but were significantly more likely to extend the proper name to the original creature. Lexical form class cues provided potent information about word meaning, directing preschoolers to reinterpret familiar descriptive terms (adjectives) as homophonic terms designating unique individuals (proper names). [less ▲]

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See detailMarine mammals from the southern North Sea: feeding ecology data from delta C-13 and delta N-15 measurements
Das, Krishna ULiege; Lepoint, Gilles ULiege; Leroy, Yann et al

in Marine Ecology. Progress Series (2003), 263

The harbour porpoise Phocoena phocoena, grey seal Halichoerus grypus, harbour seal Phoca vitulina and white-beaked dolphin Lagenorhynchus albirostris are regularly found stranded along southern North Sea ... [more ▼]

The harbour porpoise Phocoena phocoena, grey seal Halichoerus grypus, harbour seal Phoca vitulina and white-beaked dolphin Lagenorhynchus albirostris are regularly found stranded along southern North Sea coasts. Occasionally, offshore species such as the fin whale Balaenoptera physalus, the white-sided dolphin L. acutus and the sperm whale Physeter macrocephalus are also found stranded. In order to trace their diet, we measured delta(13)C and delta(15)N in their muscles as well as in 49 invertebrate and fish species collected from the southern North Sea. The delta(15)N data indicate that the harbour seal, grey seal and white-beaked dolphin occupy the highest trophic position, along with ichtyophageous fishes such as the cod Gadus morhua (mean muscle values of 18.7, 17.9, 18.8 and 19.2parts per thousand respectively). The harbour porpoise occupies a slightly lower trophic position (mean delta(15)N value of 16.2parts per thousand), reflecting a higher amount of zooplanktivorous fishes in its diet (mean delta(15)N of 14.7parts per thousand); 2 suckling harbour porpoises displayed a significant delta(15)N enrichment of 2.2parts per thousand compared to adult females. Adult females are delta(15)N-enriched compared to adult male harbour porpoises. Fin whales, sperm whales and white-sided dolphins are C-13-depleted compared to southern North Sea particulate organic matter and species, suggesting that despite regular sightings, they do not feed within the southern North Sea area. [less ▲]

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See detailLombalgies et remise au travail : Quel modèle d'intervention privilégier ?
Mairiaux, Philippe ULiege

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2003), XL(4), 185-188

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See detailModulating skeletal muscle mass by postnatal, muscle-specific inactivation of the myostatin gene.
Grobet, Luc ULiege; Pirottin, Dimitri ULiege; Farnir, Frédéric ULiege et al

in Genesis (2003), 35(4), 227-38

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular ... [more ▼]

By using a conditional gene targeting approach exploiting the cre-lox system, we show that postnatal inactivation of the myostatin gene in striated muscle is sufficient to cause a generalized muscular hypertrophy of the same magnitude as that observed for constitutive myostatin knockout mice. This formally demonstrates that striated muscle is the production site of functional myostatin and that this member of the TGFbeta family of growth and differentiation factors regulates muscle mass not only during early embryogenesis but throughout development. It indicates that myostatin antagonist could be used to treat muscle wasting and to promote muscle growth in man and animals. [less ▲]

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See detailIdentification of heterologous multicopy suppressors of the yeast msb3msb4 double mutation
Delroisse, Jean-Marc; Breban, Martine; Burny, Arsène et al

in Archives Internationales de Physiologie et de Biochimie (2003), 184

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See detailLa peine de travail - Quelques observations pratiques
Jacobs, Ann ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailCloches et plaies des pieds.
Crosset, A.; Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in Pharma-Sphère (2003), 78

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See detailPhotorefractive ZnTe grown by traveling heater method
Verstraeten, David; Launay, Jean-Claude; Delaye, Philippe et al

in Trends in Optics and Photonics (2003), 87

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See detailLeçons de l’éphémère. La Cour d’arbitrage et le "Renouveau’ électoral" – La Cour d’arbitrage et la suspension
Rosoux, Géraldine ULiege

in Revue Belge de Droit Constitutionnel (2003)

The articles analyzes the electoral reform of 2003 and points out the competence of the Belgian constitutional Court to suspend legislative norms.

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See detailCacophonie jurisprudentielle autour de la notion d’impôt
Rosoux, Géraldine ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

The article analyzes a decision of the Belgian judicial Supreme Court concerning the concept of "tax", and emphasizes the conflict between this decision and the case-law of the Belgian constitutional Court

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See detailStratégies thérapeutiques dans les adénomes somatotropes avec extension extrasellaire. Place du traitement médical. Etude consensus du Répertoire français de l'Acromégalie.
Jaquet, Ph; Cortet-Rudelli, Ch; Sassolas, G. et al

in Annales d'Endocrinologie (2003), 64(6), 434-441

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by ... [more ▼]

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by stereotactic or conventional radiotherapy. In these patients (including 37 women), aged 21-77 yr. (45.7 +/- 13.3), GH concentrations ranged from 2-260 microg/L (38.6 +/- 44.3), and IGF I from 86-967% of age-matched upper limit of normal (303 +/- 164). Maximal diameter of the adenoma at MRI was 11-36.5 mm (20.4 +/- 6.5), with cavernous sinus involvement in 68% of cases. Three subgroups were defined: 20 patients treated by long-acting somatostatin analogs only (group M), for a mean duration of 3 yr. (extremes 1-7 yr.), 48 patients initially treated by transsphenoidal surgery (group C), of whom 21 were secondarily treated by long-acting somatostatin analogs (group CM) for a mean duration of 1.2 yr. (extremes 0.2-2 yr.). All 3 groups were not statistically different in terms of tumor mass and initial levels of GH and IGF-1. Patients from group M were significantly older than those of the other groups (p<0.05). RESULTS: 46% of patients from group C after surgery vs. 45% of patients from group M had a mean GH below 2.5 microg/L. Biochemical remission (GH<2.5 microg/L and normal IGF1 normal) was obtained in 31% of cases in group C, vs. 25% in group M. In this group, a decrease of the largest tumor diameter was observed in 10 patients (71.5%), ranging from 10-25% in 7 (50%) and exceeded 50% in 3 (21.5%). In group CM, the biochemical remission rate (42%) and final GH or IGF1 values were not significantly different from group M. In conclusion, these data suggest that surgery or long-acting somatostatin analogs have a comparable efficacy in terms of remission rates in somatotroph macroadenomas with extrasellar extensions. [less ▲]

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See detailAtypical recurrent varicella in 4 patients with hemopathies.
Nikkels, Arjen ULiege; Simonart, Thierry; Kentos, Alain et al

in Journal of the American Academy of Dermatology (2003), 48(3), 442-7

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with ... [more ▼]

Relapsing varicella may occur in children with HIV infection and more rarely in younger adults. Our aim was to report unusual clinical, histologic, and virologic aspects of 4 elderly patients with malignant hemopathies who had an unusual form of recurrent varicella develop. Conventional microscopy, immunohistochemistry, and in situ hybridization were applied to smears and skin biopsy specimens. The patients presented a few dozen, scattered, large, papulovesicular lesions with central crusting. No zoster-associated pain or dermatomal distribution of the lesions was noted. Conventional microscopy revealed vascular changes and epidermal alterations typical for alpha-herpes virus infection. The varicella zoster virus major viral envelope glycoproteins gE and gB, and the immediate-early varicella zoster virus IE63 protein and the corresponding genome sequence for gE were detected on Tzanck smears; they were localized in endothelial cells and keratinocytes on skin biopsy specimens. The varicella zoster virus infection in endothelial cells, the vascular involvement, and the widespread distribution of the lesions suggest that the reported eruptions are vascular rather than neural in origin. These findings invalidate the diagnosis of herpes zoster but strongly support the diagnosis of recurrent varicella in an indolent and yet unreported presentation. Furthermore, these eruptions differ from relapsing varicella in children and young adults by the age of the patients, the paucity of clinical lesions, the larger diameter of the lesions and their peculiar clinical aspect, the significantly longer time interval between primary varicella and the recurrence, the prolonged healing time of the lesions, their mild disease course, and the fact that all the lesions are in the same stage of development. [less ▲]

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See detailEvent-related potentials to emotional and neutral stimuli in alcoholism.
Hansenne, Michel ULiege; Olin, Cecile; Pinto, Emmanuel ULiege et al

in Neuropsychobiology (2003), 48(2), 77-81

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated ... [more ▼]

Several studies have demonstrated that the emotional value of stimuli affects P300 amplitude. In the present study, the influence of alcohol-related stimuli in alcoholic patients was investigated. Subjects were 10 alcoholic inpatients (3 female) and 10 age- and sex-matched controls. Eight alcohol-related and 8 neutral words served as stimuli in a visual oddball paradigm. Acohol-related words were targets (48 stimuli, 33%) and neutral words were standard stimuli (96 stimuli, 66%). Results showed that P300 amplitude for targets did not differ significantly between the two groups. However, P300 latency for targets as well as reaction time were significantly shorter in male alcoholic patients. In contrast, P300 latency was increased in female alcoholic patients but reaction time did not differ. These results suggest that male alcoholics process information linked to alcohol cues more rapidly than neutral cues, probably because a specific semantic network is activated in these patients. The decreased reaction time confirms the impulsive behavior frequently found in male alcoholism, as it has been described in type II alcoholism. Besides, the results imply that information processing was delayed in female alcoholic patients. Therefore this study demonstrates a gender-dependent impact of alcohol-related stimuli on information processing. [less ▲]

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See detailOptimisation du protocole GPG
Hanzen, Christian ULiege; Boudry, B.

in Point Vétérinaire (2003), 34(240), 44-46

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance ... [more ▼]

Les facteurs susceptibles d’influencer les performances de reproduction permises par le protocole GPG sont multiples. L’apparition de l’oestrus et sa durée, la fréquence de l’ovulation, la croissance folliculaire, tout comme la progestéronémie, sont susceptibles d’être influencés par le stade du cycle auquel le protocole est mis en place. Le taux de gestation est d’autant plus élevé que la proportion d’animaux en anoestrus dans le troupeau est faible. Ceci explique sans doute en partie pourquoi la fertilité se trouve améliorée lorsque l’insémination suivant le traitement est effectuée après le 75e jour de lactation. De même, des résultats préliminaires confirment l’application potentielle du protocole au traitement des kystes ovariens. [less ▲]

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See detailAlcoolisme ou aldehydisme : Role de l'acetaldehyde dans les effets psychotropes de l'alcool
Quertemont, Etienne ULiege

in Alcoologie et Addictologie (2003), 25(1), 33-39

De récentes études ont suggéré que l’acétaldéhyde, premier produit du métabolisme de l’éthanol, participe aux effets psychotropes résultant de la consommation d’alcool. L’acétaldéhyde semble ... [more ▼]

De récentes études ont suggéré que l’acétaldéhyde, premier produit du métabolisme de l’éthanol, participe aux effets psychotropes résultant de la consommation d’alcool. L’acétaldéhyde semble particulièrement impliqué dans les effets renforçants de l’éthanol, ce qui suggère un rôle important pour ce métabolite dans l’abus d’alcool et l’alcoolisme. Cette mise au point passe en revue les preuves expérimentales qui tendent à démontrer le rôle de l’acétaldéhyde dans les effets psychotropes de l’alcool. Les études animales et humaines indiquent que l’acétaldéhyde exerce une action renforçante plus puissante que l’éthanol dans le cerveau. Au contraire, il semble que l’accumulation d’acétaldéhyde dans le sang périphérique provoque des effets désagréables et une aversion pour l’alcool. Les effets hédoniques de l’acétaldéhyde seraient donc déterminés par le lieu, central ou périphérique, de son accumulation principale. Toutefois, l’acétaldéhyde ne doit pas être considéré comme le seul principe actif responsable de tous les effets psychotropes de l’éthanol. Plusieurs études ont par exemple démontré que l’acétaldéhyde ne participe pas significativement aux effets subjectifs de l’éthanol. Si l’acétaldéhyde exerce effectivement un rôle dans les effets renforçants de l’éthanol, il ne doit donc pas être tenu pour responsable de tous les effets pharmacologiques de la consommation d’alcool. [less ▲]

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See detailMycotoxins in stored Barley (Hordeum vulgare) in Tibet Autonomous Region (People’s Republic of China.
Haubruge, Eric ULiege; Chasseur, Camille

in Mountain Research & Development (2003), 23

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See detailChromomycose autochtone chez une patiente immunodéprimée.
Quatresooz, Pascale ULiege; Dethier, F.; Pierard, Gérald ULiege

in Dermatologie Actualité (2003), 74

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See detailRhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.
Clercx, Cécile ULiege; Reichler, I.; Peeters, Dominique ULiege et al

in Journal of Veterinary Internal Medicine (2003), 17(6), 843-9

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK ... [more ▼]

This study describes the clinical, immunologic, genetic, and pathologic features of Irish Wolfhounds with rhinitis/bronchopneumonia syndrome. The dogs examined were from Belgium, The Netherlands, UK, Canada, Germany, and Switzerland. Signs included transient to persistent mucoid or mucopurulent rhinorrhea, cough, and respiratory dyspnea. Radiographic, rhinoscopic, and bronchoscopic findings were variable. Analysis of ciliary ultrastructure was performed in 5 affected dogs, but no characteristic primary ciliary defects (primary ciliary dyskinesia) were detected. Serum and bronchoalveolar lavage fluid (BALF) concentrations of IgA, IgG, and IgM were determined in some affected dogs and clinically normal Irish Wolfhounds. Serum IgA concentration was below the reference range in 5 of 8 affected dogs tested, whereas BALF IgA concentration was above the normal range in 2 affected adult dogs. The CD4 to CD8 lymphocyte subset ratio (CD4:CD8) in peripheral blood was tested in 3 affected dogs and was within the normal range. BALF CD4:CD8 was tested in 1 affected dog and was higher than the normal range. Decreased neutrophil phagocytosis was observed in 1 of the 4 dogs tested. Analysis of pedigrees of the Belgian, Canadian, German, and Swiss dogs revealed common ancestry, suggesting a heritable syndrome. [less ▲]

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See detailEnergy conservation and dissipation in mitochondria isolated from developing tomato fruit of ethylene-defective mutants failing normal ripening: the effect of ethephon, a chemical precursor of ethylene.
Navet, R.; Jarmuszkiewicz, W.; Almeida, A. et al

in Journal of Bioenergetics & Biomembranes (2003), 35(2), 157-168

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two ... [more ▼]

Alternative oxidase (AOX) and uncoupling protein (UCP) are present simultaneously in tomato fruit mitochondria. In a previous work, it has been shown that protein expression and activity of these two energy-dissipating systems exhibit large variations during tomato fruit development and ripening on the vine. It has been suggested that AOX and UCP could be responsible for the respiration increase at the end of ripening and that the cytochrome pathway could be implicated in the climacteric respiratory burst before the onset of ripening. In this study, the use of tomato mutants that fail normal ripening because of deficiencies in ethylene perception or production as well as the treatment of one selected mutant with a chemical precursor of ethylene have revealed that the bioenergetics of tomato fruit development and ripening is under the control of this plant hormone. Indeed, the evolution pattern of bioenergetic features changes with the type of mutation and with the introduction of ethylene into an ethylene-synthesis-deficient tomato fruit mutant during its induced ripening. [less ▲]

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See detailHistomycologie unguéale
Arrese Estrada, Jorge ULiege; Quatresooz, Pascale ULiege; Franchimont, Claudine ULiege et al

in Annales de Dermatologie et de Vénéréologie (2003), 130

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The ... [more ▼]

The diversity of onychomycoses is large when the disease is scrutinized using traditional, fluorescence or confocal microscopy. Histomycology is a non-invasive assessment performed on nail clippings. The location of and the density in fungal cells is variable. In some instances, these aspects remain clinically unsuspected. In vivo confocal microscopy can bring the same information. Computerized image analysis of histological sections is the most performant means for quantifying the fungal load. Immunohistochemistry brings information about the identity of the fungus or the association of different fungi present in the nail plate. Mixed infections may be unifocal or located at different levels in the nail apparatus. The viability of fungi as assessed by vital stains can be assessed under the microscope and quantified by flow cytometry. The different facets of nail histomycology are complementary and shed some light on aspects sometimes unsuspected of onychomycoses. [less ▲]

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See detailSapling diversity in canopy gaps in an Ecuadorian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULiege; Zak-Mnacek, V et al

in Forest Science (2003), 49(6), 909-917

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See detailFormation continue en jonglerie
Fischbach, Willi; Cloes, Marc ULiege

in Revue de l'Education Physique (2003), 43(4), 114-125

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de ... [more ▼]

Le premier auteur est étudiant passionné de jonglerie, il a réalisé un mémoire de fin d’études portant sur l’utilisation de la jonglerie en milieu scolaire. Cet article est préparé à partir du contenu de formations continuées proposées aux maîtres de stage qui collaborent à la formation des étudiants de l’AESS de l’Institut Supérieur d’Education Physique et de Kinésithérapie de l’ULg. [less ▲]

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See detailThe Zápara Indians : the Consecration of an Endangered People
Bilhaut, Anne-Gaël ULiege

in Museum International (2003), 55(2), 25-30

Focuses on the United Nations Educational, Scientific and Cultural Organization's (UNESCO) declaration of the oral heritage and cultural manifestations of the Zápara people of Amazonia as a 'Masterpiece ... [more ▼]

Focuses on the United Nations Educational, Scientific and Cultural Organization's (UNESCO) declaration of the oral heritage and cultural manifestations of the Zápara people of Amazonia as a 'Masterpiece of the Oral and Intangible Heritage of Humanity.' Impact that the UNESCO recognition has had on the Zápara; Details of how the Zápara were able to secure sacred status from the UNESCO. [less ▲]

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See detailEstimating internal pelvic sizes using external body measurements in the double-muscled Belgian Blue beef breed
Coopman, F.; de Smet, S.; Gengler, Nicolas ULiege et al

in Animal Science (2003), 76(Part 2), 229-235

In the double-muscled (DM) Belgian Blue beef (BBB) breed, caesarean section (CS) is being applied systematically as a management tool to prevent dystocia. As a matter of fact, CS is the only possible way ... [more ▼]

In the double-muscled (DM) Belgian Blue beef (BBB) breed, caesarean section (CS) is being applied systematically as a management tool to prevent dystocia. As a matter of fact, CS is the only possible way of calving in the breed. High birth weight and a relatively small pelvic area are the main causes of dystocia and, in the DM-BBB breed, the reasons for the systematically applied CS. Selection for lower birth weight and larger pelvic sizes might reduce dystocia and routine CS. Few data on inner pelvic sizes of pedigree animals are available. Using external measurements to estimate the inner pelvic sizes might be an option to resolve this problem. In this study, animals of the DM-BBB breed were measured and weighed on farms and in abattoirs. External and internal pelvic sizes increased with live weight and age of the animals. Gender had a significant influence on inner pelvic traits. Increased muscular conformation was associated with decreased inner pelvic dimensions. Models with weight, gender, age, withers height and outer pelvic width (TcTc) can be used to estimate inner pelvic sizes (R-2 between 0.35 and 0.77). The estimated inner pelvic sizes can then be used to genetically evaluate pelvic traits in the DM-BBB breed. Improving weight, withers height and TcTc width in combination with lowering muscular conformation may help to decrease the high rate of caesarean section in the DM-BBB. [less ▲]

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See detailQuand l’employeur ne respecte pas les barèmes de rémunération
Kefer, Fabienne ULiege

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2003), (8/9), 22-26

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See detailAnatomical and histological aspects of the tonsils in sheep
Gabriel, Annick ULiege; Cocquyt, G.; Van den Broeck, W.

in Annales de Médecine Vétérinaire (2003), 147(4, AUG-SEP), 251-258

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence ... [more ▼]

Since the 1st April 2002, the European Union has extended the Transmissible Spongiform Encephalopathy testing in ruminants by including sheep and goats in the survey studies. In small ruminants, presence of the agent of Bovine Spongiform Encephalopathy was demonstrated in tonsils, so these are considered as specified risk materials. This article gives an overview of the anatomical localisation and histological structure of the tonsils in small ruminants. Anatomically, 6 different tonsils can be distinguished: 3 are located in the oropharyngeal tract (tonsilla palatina, tonsilla lingualis, tonsilla veli palatini), 2 in the nasopharyngeal tract (tonsilla pharyngea and tonsilla tubaria), and one in the laryngopharyngeal tract (tonsilla paraepiglottica). Several tonsils show a cryptic overlying epithelium (cryptic tonsil) whereas other don't (non-cryptic tonsil). Several immunological features of the tonsils are described. [less ▲]

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULiege; De Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Pratique Vétérinaire Equine (2003), 35(139), 23-29

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ... [more ▼]

An acute respiratory attack with bronchospasm is associated with excessive stimulation of the parasympathic nervous system. It may be reduced by administration of anticholinergic agents. Atropine and ipratropium bromide have been tested. This study is to evaluate the efficacy of the synthetic antimuscarinic compound glycopyrrolate as a bronchodilator in horses. Respiratory crisis was induced in seven allergic horses by exposure to natural allergens. Prior to the study, it was established that the attack could be stopped using intravenous atropine sulphate. Pulmonary function tests (ventilation and arterial blood gas analysis) were performed on the horses before and then after aerosol administration of 1500 µg of glycopyrrolate (Robinul®). The attack was characterised by an increase in total pulmonary resis¬tance and maximum pleural pressure variation and by decreased compliance. This study demonstrates that glycopyrrolate exhibits affects that are just as rapid and effective as intravenous atropine or aerosol administration of 1200 µg dry powder Ipratropium. In addi¬tion the treatment was well tolerated and no side-effects were observed in contrast to those seen with intravenous administration of atro¬pine. Therefore this drug has an important role to play among the therapeutics available to practitioners for acute respiratory attacks in horses [less ▲]

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See detailTransmission of CARD15 (NOD2) variants in families with Crohns disease
Vermeire, S.; Esters, N.; Pierik, M. et al

in Gastroenterology (2003), 124(4 (Suppl I)), 368

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See detailL'interférence virale chez les Alphaherpesvirinae
Meurens, François; Muylkens, Benoît ULiege; Schynts, Frédéric et al

in Virologie (2003), 7

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See detailGuidelines for the use of epoetin: have quality-of-life benefits been proven?
Bottomley, Andrew; Thomas, Ronald; Van Steen, Kristel ULiege et al

in Journal of Clinical Oncology (2003), 21(11), 22232224-5

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See detailLes facteurs de virulence des alphaherpèsvirus
Muylkens, Benoît ULiege; Meurens, François; Schynts, Frédéric et al

in Virologie (2003), 7

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See detailA local influence approach applied to binary data from a psychiatric study.
Jansen, Ivy; Molenberghs, Geert; Aerts, Marc et al

in Biometrics (2003), 59(2), 410-9

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to ... [more ▼]

Recently, a lot of concern has been raised about assumptions needed in order to fit statistical models to incomplete multivariate and longitudinal data. In response, research efforts are being devoted to the development of tools that assess the sensitivity of such models to often strong but always, at least in part, unverifiable assumptions. Many efforts have been devoted to longitudinal data, primarily in the selection model context, although some researchers have expressed interest in the pattern-mixture setting as well. A promising tool, proposed by Verbeke et al. (2001, Biometrics 57, 43-50), is based on local influence (Cook, 1986, Journal of the Royal Statistical Society, Series B 48, 133-169). These authors considered the Diggle and Kenward (1994, Applied Statistics 43, 49-93) model, which is based on a selection model, integrating a linear mixed model for continuous outcomes with logistic regression for dropout. In this article, we show that a similar idea can be developed for multivariate and longitudinal binary data, subject to nonmonotone missingness. We focus on the model proposed by Baker, Rosenberger, and DerSimonian (1992, Statistics in Medicine 11, 643-657). The original model is first extended to allow for (possibly continuous) covariates, whereafter a local influence strategy is developed to support the model-building process. The model is able to deal with nonmonotone missingness but has some limitations as well, stemming from the conditional nature of the model parameters. Some analytical insight is provided into the behavior of the local influence graphs. [less ▲]

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See detailMesure de l'effet de l'hyperimmunisation pour le contrôle de la rhinotrachéite infectieuse bovine dans les troupeaux laitiers en Belgique : analyse de survie
Dispas, Marc; Kerkhofs, Pierre; Thiry, Etienne ULiege

in Epidémiologie et Santé Animale (2003), 44

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See detailQu'est-ce qu'une maladie émergente?
Toma, B.; Thiry, Etienne ULiege

in Epidémiologie et Santé Animale (2003), 44

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See detailComment j'explore ... une tache noire au cours de la grossesse. Une tache parfois difficile pour le clinicien.
Uhoda, I.; Pierard, Claudine ULiege; Arrese Estrada, Jorge ULiege et al

in Revue Médicale de Liège (2003), 58(12), 766-9

Cancers rarely coexist with pregnancy. Cutaneous melanoma, however, is one of the most frequently encountered neoplasms during pregnancy. Gestation may also be a period during which the aspect of some ... [more ▼]

Cancers rarely coexist with pregnancy. Cutaneous melanoma, however, is one of the most frequently encountered neoplasms during pregnancy. Gestation may also be a period during which the aspect of some melanocytic naevi can change eventhough the tumor remains benign. Distinction between a benign and a malignant lesion may then be a dilemma. Clinical morphometry, dermoscopy, skin surface biopsy, conventional histology and immunohistochemistry are valuable means that can be used to secure maximum diagnostic confidence. [less ▲]

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See detailCell cycle duration at the time of maternal zygotic transition for in vitro produced bovine embryos: effect of oxygen tension and transcription inhibition.
Lequarré, Anne-Sophie ULiege; Marchandise, J.; Massip, A. et al

in Biology of Reproduction (2003), 69(5), 1707-13

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to ... [more ▼]

Early embryonic cleavages are mostly regulated by maternal components then control of development progressively depends on newly synthesized zygotic products. The timing of the first cleavages is a way to assess embryo quality. The goal of this study was to evaluate the duration of the fourth cell cycle, at the time of maternal-to-zygotic transition (MZT) in in vitro-produced bovine embryos by means of cinematographic analysis. We found that 75% of the embryos displayed a long fourth cycle (43.5 +/- 5.4 h) whereas the remaining embryos had a very short fourth cell cycle (8.9 +/- 2.9 h). Both groups did not differ in cleavage rhythm up to the eight-cell stage and timing of cavitation and blastocyst expansion was identical. However, embryos with a short fourth cell cycle had a better blastocyst rate than embryos with a long cycle (59% versus 38%, P < 0.01). Total cell number, inner cell mass (ICM):total cell ratio, and hatching rate were identical for blastocysts produced from embryos with either a long or a short fourth cell cycle. In a second experiment, we showed that increasing the oxygen tension, from 5% to 20%, decreased the percentage of embryos with a short fourth cell cycle, from 25% to 11% (P < 0.01), indicating that suboptimal culture conditions can influence the length of this cycle. Finally, we investigated whether fourth cell cycle duration could be influenced by transcription inhibition. With alpha-amanitin added at 18 h postinsemination (HPI), cleavage was reduced (66% versus 79%) and, at 70 HPI, the 9- to 16-cell rate increased (50% versus 25%) concomitantly with a 5- to 8-cell rate decrease (16% versus 47%). A similar pattern was observed when the drug was added at 6 HPI or 42 HPI but not at 0 HPI. Cinematographic analysis revealed that alpha-amanitin increased the first cell cycle duration whereas the second and third cell cycles were not affected. With the drug, one third of the embryos could develop up to the 9- to 16-cell stage and they all had a short fourth cell cycle (11.2 +/- 3.7 h) with a good synchrony of cleavage between blastomeres. These results suggest that duration of the fourth cell cycle of bovine embryo, during the MZT, is under a zygotic transcriptional control that can be affected by oxidative conditions. [less ▲]

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See detailComment j'explore ... un nez rouge.
Pierard, Claudine ULiege; Henry, Frédérique ULiege; Rakic, L. et al

in Revue Médicale de Liège (2003), 58(7-8), 515-8

A red nose is a semiological sign shared in common by a series of diseases. The differential diagnosis is important to establish. A careful clinical examination often allows to reach the precise diagnosis ... [more ▼]

A red nose is a semiological sign shared in common by a series of diseases. The differential diagnosis is important to establish. A careful clinical examination often allows to reach the precise diagnosis. A skin biopsy is required when erythema is accompanied by a cutaneous infiltration suggesting some granulomatous and tumoral processes. [less ▲]

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See detailLa cartographie et la géomatique
Donnay, Jean-Paul ULiege

in Bulletin de la Société Géographique de Liège (2003), 43

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See detailImiquimod-responsive basal cell carcinomas and factor XIIIa-enriched dendrocytes.
Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Clinical & Experimental Dermatology (2003), 28 Suppl 1

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 ... [more ▼]

Dermal dendrocytes (DDs) are dendritic cells that exhibit immunoreactivity for factor XIIIa, and are frequently found in conjunction with basal cell carcinomas (BCCs). Imiquimod was applied to 12 superficial BCCs every 3 days for 8 weeks. One week after completion of treatment, seven lesions appeared to have resolved, while five displayed evidence of residual BCC. Prior to initiation of treatment, the seven imiquimod-responsive BCCs were surrounded by numerous DDs, whereas the five imiquimod-resistant BCCs had fewer DDs next to them at the time of entry into the study. It appears that the pretreatment density in DDs may affect the efficacy of imiquimod in eradicating skin tumours. [less ▲]

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See detailSentence processing strategies in French-speaking children with SLI: a study of morphosyntactic cues
Maillart, Christelle ULiege; Schelstraete, Marie-Anne

in Journal of Multilingual Communication Disorders (2003), 1

The sentence comprehension strategies used by children with speci®c language impairments (SLI) were examined within the framework of the Competition Model (Bates and MacWhinney, 1989). The experiment was ... [more ▼]

The sentence comprehension strategies used by children with speci®c language impairments (SLI) were examined within the framework of the Competition Model (Bates and MacWhinney, 1989). The experiment was a replication of Kail and Charvillat'experiment (1988) designed to investigate the use of different morphosyntactic cues (i.e. word order, clitic pronoun, verbal agreement) in sentence comprehension by children (4;6 ± 6;6) with normal language development. They found that French speaking children used mainly information on word order with a lesser reliance on the other cues (word order4clitic pronoun4verbal agreement). In the present study, the same experiment was replicated with 25 French speaking children with SLI. The results suggested that children with SLI had speci®c di culties in processing clitic pronouns, while verbal agreement could be processed (word order4verbal agreement4clitic pronoun). This pattern seems to be a speci®c strategy and not simply a delayed pro®le. In addition, our results were compatible with a theoretical account in terms of limitation in processing capacities. [less ▲]

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See detailSkin-lightening products revisited.
Petit, Ludivine; Pierard, Gérald ULiege

in International Journal of Cosmetic Science (2003), 25(4), 169-81

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and ... [more ▼]

Skin colour typology depends on the amount and location of its chromophores. Among them, eumelanins derived from 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI), and phaeomelanins are of utmost importance. These biomolecules result from the multi-step enzymatic and non-enzymatic conversion of tyrosine into melanins. Pigmentation disorders are multiple and depend on alterations in the density in active melanocytes, and on specific abnormalities of any of the complex melanogenesis mechanisms. This review presents some of the main skin-lightening agents with respect to their mechanisms of action and side-effects. Some of the novel compounds may lead to new perspectives in the fields of dermatology and cosmetology. The methods commonly used to assess efficacy of skin-lightening products rely on in vitro models including cell-free enzymatic assays, melanocyte cultures and reconstructed epidermis bioassays. Animal models have little relevance. By contrast, human testing with the support of instrumental evaluations is the most informative. [less ▲]

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See detailCutaneous psammomatous melanotic schwannoma: non-recurrence with surgical excision.
Claessens, Nadine; Heymans, Olivier; Arrese Estrada, Jorge ULiege et al

in American Journal of Clinical Dermatology (2003), 4(11), 799-802

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which ... [more ▼]

BACKGROUND: Melanotic schwannoma is a pigmented nerve tumor that may be located in the skin and express local aggressivity. This tumor may occur singly. It may also be part of the Carney complex which consists of various, but specific, tumors. OBJECTIVE: We report two cases of subcutaneous melanotic schwannoma localized on the trunk in two men aged 37 and 45 years. METHODS: Conventional histology and immunohistochemistry were performed. RESULTS: One melanotic schwannoma was associated with a cutaneous atypical myxoma and multiple melanocytic lesions, all being part of the Carney complex. The other case had no associated signs. In both cases, the melanotic schwannoma was completely excised and did not recur. CONCLUSION: Melanotic schwannoma is rare and curable by surgery. It must not be confused with malignant melanoma and other pigmented neoplasms. The Carney complex should be carefully ruled out. [less ▲]

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See detailThe hair eclipse phenomenon: sharpening the focus on the hair cycle chronobiology.
Pierard, Claudine ULiege; Petit, L.; Loussouarn, G. et al

in International Journal of Cosmetic Science (2003), 25(6), 295-9

Chronobiology governing the hair cycle is a fascinating and complex process. Both the hair growth cycle and the hair shaft growth are coordinated and depend on the interplay of different biological ... [more ▼]

Chronobiology governing the hair cycle is a fascinating and complex process. Both the hair growth cycle and the hair shaft growth are coordinated and depend on the interplay of different biological signals and various exogenous stimuli. A latency period may occur between hair shedding (teloptosis, exogen phase) and the early emergence of the next anagen VI stage. This lag time referred to on the hair eclipse phenomenon likely depends on the influence of a series of distinct synchronizers, and does not represent per se a peculiar hair cycle phase. It is the result of some dysregulations of the hair cycling, involving early teloptosis, delayed anagen I initiation or stunted hair growth at any stage between the anagen I and anagen V phases. As such, the hair eclipse phenomenon may be an erratic process occurring in physiopathological conditions affecting hair follicles singly or in focal to generalized patterns. It may be more frequent when it follows synchronized teloptosis occurring in telogen effluvium (newborn alopecia, post-partum alopecia, seasonal alopecia and alopecia areata). It may also be prominent when microinflammation is abutted on the permanent portion of the hair follicle as in dandruff, seborrhoeic dermatitis, androgenic alopecia and photoageing baldness. Local synchronizers such as growth factors and other mediators may eventually be lacking or involved in the hair eclipse phenomenon. Their identification and characterization might drive new corrective or preventive applications. [less ▲]

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See detailLes lymphomes
Jerusalem, Guy ULiege; Hustinx, Roland ULiege; Beguin, Yves ULiege et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2003), 27(8), 401-410

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique ... [more ▼]

Actuellement, on arrive à guérir 70-80% des patients atteints de maladie de Hodgkin et 50% des patients atteints de lymphome non-Hodgkinien de malignité intermédiaire ou élevée. Une approche systématique concernant le diagnostic, la classification de la maladie et la détermination des facteurs pronostiques permet de choisir la thérapeutique la plus appropriée. Les auteurs passent en revue les examens à réaliser au diagnostic et discutent de la place de la tomographie à émission de positons (TEP) dans cette indication. Ils évoquent ensuite le problème des masses résiduelles. La TEP est maintenant l'examen de choix pour établir le bilan de fin de traitement. Les auteurs discutent également du rôle potentiel de la TEP pour l'évaluation thérapeutique précoce et le suivi régulier des patients après traitement pour lymphome. Enfin, l'aspect particulier des lymphomes de l'enfant est abordé. [less ▲]

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See detailThe contribution of recollection and familiarity to recognition memory : A study of the effects of test format and aging
Bastin, Christine ULiege; Van der Linden, Martial ULiege

in Neuropsychology (2003), 17(1), 14-24

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the ... [more ▼]

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the performance of 64 young (mean age = 21.7 years; mean education = 14.5 years) and 62 older participants (mean age = 64.4 years; mean education = 14.2 years) on a yes–no and a forced-choice recognition task for unfamiliar faces using the remember– know–guess procedure. Familiarity contributed more to forced-choice than to yes–no performance. Moreover, older participants, who showed a decrease in recollection together with an increase in familiarity, performed better on the forced-choice task than on the yes–no task, whereas younger participants showed the opposite pattern. [less ▲]

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See detailLe catastérisme chez Homère. Le cas d'Orion
Renaud, Jean-Michel ULiege

in Gaia. Revue interdisciplinaire sur la Grèce archaïque (2003), 7

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See detailComment je traite ... une hypertrichose.
Pierard, Claudine ULiege; Henry, Frédérique ULiege; Paquet, Philippe ULiege et al

in Revue Médicale de Liège (2003), 58(10), 605-10

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most ... [more ▼]

Hypertrichosis can result from various origins and exhibit diverse clinical presentations. Any etiological treatment, when available, does not always lead to regression of the excess in pilosity. Most often, hypertrichosis represents a real esthetic burden and affects the patient's self-esteem. Currently the laser epilation technique offers new and promising therapeutic possibilities. [less ▲]

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See detailAnalyses technologiques d'un atelier de taille aurignacien à Maisières - Canal (Province du Hainaut, Belgique)
Miller, Rebecca ULiege; Flas, Damien; Guillaume, Alain et al

in Notae Praehistoricae (2003), 23

This articles presents the results of the spatial distribution of lithic refits and a dynamic technological analysis of the Aurignacian assemblage from the site of Maisières-Canal.

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See detailTrou Al'Wesse : Rapport préliminaire des fouilles 2003
Miller, Rebecca ULiege; Otte, Marcel ULiege

in Notae Praehistoricae (2003), 23

This article presents a summary of the first field season of the second phase of excavations at the site of Trou Al'Wesse as well as proposing a series of hypotheses concerning possible contacts between ... [more ▼]

This article presents a summary of the first field season of the second phase of excavations at the site of Trou Al'Wesse as well as proposing a series of hypotheses concerning possible contacts between Mesolithic and Neolithics populations. [less ▲]

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See detailNote sur les hétéroptères des cultures maraîchères de plein champ
Colignon, P.; Francis, Frédéric ULiege; Haubruge, Eric ULiege

in Notes Fauniques de Gembloux (2003), 51

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See detailJambes lourdes et microangiopathie de stase. Approches préventives et thérapeutiques.
Henry, Frédérique ULiege; Paquet, Philippe ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2003), 58(6), 435-8

Venous insufficiency of the legs is a frequent and insidious disorder which, through its consequences' cascade, lead to some cutaneous microangiopathy with relative ischemia. Chronic leg ulcer is the late ... [more ▼]

Venous insufficiency of the legs is a frequent and insidious disorder which, through its consequences' cascade, lead to some cutaneous microangiopathy with relative ischemia. Chronic leg ulcer is the late issue of the process accompanied by varied medical and socio-economic aspects. The pathogeny of the cutaneous lesions is directly related to alterations in hemorrheology and leukocyte adhesion inside capillaries. Elastic contention and some venotropic drugs exert preventive effects on the development of leg ulcers. They also bring some therapeutic improvement of the symptoms of leg heaviness. [less ▲]

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See detailA note on the age of radioactive tracers
Delhez, Eric ULiege; Deleersnijder, Eric; Mouchet, Anne ULiege et al

in Journal of Marine Systems (2003), 38(3-4), 277-286

wThe age of a water mass is often estimated experimentally using the radio-age computed from the distribution of a radioactive tracer (radiocarbon, helium-tritium). Deleersnijder et al. [J. Mar. Syst. 28 ... [more ▼]

wThe age of a water mass is often estimated experimentally using the radio-age computed from the distribution of a radioactive tracer (radiocarbon, helium-tritium). Deleersnijder et al. [J. Mar. Syst. 28 (2001) 229.] have shown that the radio-age underestimates the age of the water and is larger than the age of the radioactive tracer used for its evaluation. This result is generalized here to radio-ages computed from the ratio of two radioactive tracers. The differences between the different ages are also studied analytically and numerically as functions of the decay rate of the radioactive tracers. For small decay rates, the difference between the age of the water mass and the radio-age is shown to be proportional to the decay rate. It depends also on the level of mixing in the system; even radioactive tracers with small decay rates can provide poor estimates of the age of the water mass in a strongly diffusive flow. For small half lives, both the radio-age and the age of radioactive tracers decrease as the inverse of the square root of the decay rate. The same analysis applies to some extent to the estimates of the age of a water mass from stable tracers with known time dependent sources (e.g. chloroflurocarbons). (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailMarchés immobiliers résidentiels et étalement urbain contraint. L'accessibilité au logement au sein de la région métropolitaine bruxelloise
Dubois, O.; Halleux, Jean-Marie ULiege

in Belgeo (2003), (3), 303-327

The release of mobility constraints has facilitated urban sprawl, i.e. the increasing spatial dissociation between urban cores and implantation sites of households and economic activities. The aim of this ... [more ▼]

The release of mobility constraints has facilitated urban sprawl, i.e. the increasing spatial dissociation between urban cores and implantation sites of households and economic activities. The aim of this paper about the Walloon part of the Brussels metropolitan region is to analyse how housing market constraints reinforce the trend towards residential sprawl. Based on an analysis of the financial accessibility to both, the market for new housings and the market for pre-existing housings, it is here the influence of the price level decreasing with the distance from Brussels which is taken into account. Due to their limited financial resources and to this price gradient, many households are obliged to settle on remote sites in order to acquire their property goods. In relation to this phenomenon, it appears that, from a spatial as well as from a social point of view, the Brussels urban system is not able to settle the metropolitan growth on an adapted way. Indeed, new residential locations reinforce the increasing dissociation between work places and living places, which leads to a useless increase in mobility costs as well as a serious accentuation of socio-spatial segregations. [less ▲]

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See detailGolden shares, droit des sociétés et marché intérieur
Thirion, Nicolas ULiege

in Cahiers de Droit Européen (2003)

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See detailDavid A. Jackson: Theodor Storm. Dichter und demokratischer Humanist, Berlin 2001.
Gerrekens, Louis ULiege

in Schriften der Theodor-Storm-Gesellschaft (2003), 52

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See detailnote sous arrêt du 23 octobre 2003, Van den Bergh Foods contre Commission
Petit, Nicolas ULiege

in Revue du Droit de l'Union Européenne (2003)

résumé et analyse de l'affaire Volkswagen AG contre Commission, affaire C-338/00

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See detailFreezing of water bound in lichen thallus as observed by H-1 NMR. 1. Freezing of loosely bound water in Cladonia mitis at different hydration levels
Haranczyk, Hubert; Grandjean, Jean ULiege; Olech, M.

in Colloids and Surfaces B : Biointerfaces (2003), 28

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See detailRole of ERK and calcium in the hypoxia-induced activation of HIF-1.
Mottet, Denis ULiege; Michel, Gaetan; Renard, Patricia et al

in Journal of Cellular Physiology (2003), 194(1), 30-44

Oxygen-dependent regulation of HIF-1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF-1alpha protein expression have been most extensively analyzed but the ones modulating HIF-1 ... [more ▼]

Oxygen-dependent regulation of HIF-1 activity occurs at multiple levels in vivo. The mechanisms regulating HIF-1alpha protein expression have been most extensively analyzed but the ones modulating HIF-1 transcriptional activity remain unclear. Changes in the phosphorylation and/or redox status of HIF-1alpha certainly play a role. Here, we show that ionomycin could activate HIF-1 transcriptional activity in a way that was additive to the effect of hypoxia without affecting HIF-1alpha protein level. In addition, a calmodulin dominant negative mutant and W7, a calmodulin antagonist, as well as BAPTA, an intracellular calcium chelator, inhibited the hypoxia-induced HIF-1 activation. These results indicate that elevated calcium in hypoxia could participate in HIF-1 activation. Furthermore, ERK but not JNK phosphorylation was evidenced in both conditions, ionomycin and hypoxia. PD98059, an inhibitor of the ERK pathway as well as a ERK1 dominant negative mutant also blocked HIF-1 activation by hypoxia and by ionomycin. A MEKK1 (a kinase upstream of JNK) dominant negative mutant had no effect. In addition, BAPTA, calmidazolium, a calmodulin antagonist and PD98059 inhibited VEGF secretion by hypoxic HepG2. All together, these results suggest that calcium and calmodulin would act upstream of ERK in the hypoxia signal transduction pathway. [less ▲]

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See detailEffect of polystyrene particles on lung mirovascular permeability in isolated perfused rabbit lungs : role of size and surface proporties
Hamoir, J.; Nemmar, A.; Halloy, D. et al

in Toxicology and Applied Pharmacology (2003), 190

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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULiege; Lekeux, Pierre ULiege

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailEditorial. Vers le troisième départ du mélèze en Région wallonne
Hebert, Jacques ULiege

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(1), 3-4

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See detailFin de législature: le point sur l'autonomie fiscale des communautés et des régions
Bourgeois, Marc ULiege

in Comptabilité et Fiscalité Pratiques (2003)

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See detailSpontaneous zygogenesis in Escherichia coli, a form of true sexuality in prokaryotes.
Gratia, Jean*-Pierre; Thiry, Marc ULiege

in Microbiology (2003), 149(Pt 9), 2571-84

A new type of mating, differing from classic conjugation and previously observed in a certain strain of Escherichia coli K-12, has also been found in strains derived from ordinary F- cells of E. coli K-12 ... [more ▼]

A new type of mating, differing from classic conjugation and previously observed in a certain strain of Escherichia coli K-12, has also been found in strains derived from ordinary F- cells of E. coli K-12 exposed to an exogenous factor originating in an E. coli clinical isolate. Immunofluorescence and electron microscopy after single and double labelling of DNA were used to produce evidence in favour of a novel mating mechanism by cell contact at the poles of the bacterial rod. These findings are supported by genetic analyses indicating complete genetic mixing. Unstable complementing diploids were formed, which throw off phenotypically haploid cells, of which some showed a parental phenotype and some were true genetic recombinants. Recombination was observed even when one parent was a UV-inactivated F- RecA- strain. The name 'spontaneous zygogenesis' (Z-mating, for short) is proposed for this kind of mating. [less ▲]

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See detailImmunocytochemical detection of DNA and RNA in endosymbiont-bearing trypanosomatids.
Motta, Maria Cristina M; de Souza, Wanderley; Thiry, Marc ULiege

in FEMS Microbiology Letters (2003), 221(1), 17-23

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these ... [more ▼]

Research about the kinetoplast of trypanosomatids has yielded valuable information about the organization of extranuclear structure. However, the ultrastructural localization of nucleic acids within these protozoa remains uncertain. We have applied cytochemical and immunocytochemical approaches to precisely identify DNA and RNA in lower endosymbiont-bearing trypanosomatids. Using the Terminal deoxynucleotidyl Transferase (TdT) immunogold technique, we showed that nuclear DNA is seen associated with the nuclear envelope during the trypanosomatid cell cycle. By combining the TdT technique with the acetylation method, which improves the contrast between structures containing fibrils and granules, we have demonstrated that the nucleolus of endosymbiont-bearing trypanosomatids is composed of two constituents: a granular component and a DNA-positive fibrillar zone. Moreover, we revealed that DNA of endosymbiotic bacteria consisted of electron-dense filaments which are usually in close contact with the prokaryote envelope. Using a Lowicryl post-embedding immunogold labeling procedure with anti-RNA antibodies, we showed the presence of RNA not only over the cytoplasm, the interchromatin spaces and the nucleolus, but also over the kinetoplast and virus-like particles present in Crithidia desouzai. [less ▲]

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See detail50-60 Hz electric and magnetic field effects on cognitive function in humans: A review
Crasson, Marion ULiege

in Radiation Protection Dosimetry (2003), 106(4), 333-340

This paper reviews the effect of 50-60 Hz weak electric, magnetic and combined electric and magnetic field exposure on cognitive functions such as memory, attention, information processing and time ... [more ▼]

This paper reviews the effect of 50-60 Hz weak electric, magnetic and combined electric and magnetic field exposure on cognitive functions such as memory, attention, information processing and time perception, as determined by electroencephalographic methods and performance measures. Overall, laboratory studies that have investigated the acute effects of power frequency fields on cognitive functioning in humans are heterogeneous, in terms of both electric and magnetic field (EMF) exposure and the experimental design and measures used. Results are inconsistent and difficult to interpret with regard to functional relevance for possible health risks. Statistically significant differences between field and control exposure, when they are found, are small, subtle, transitory, without any clear dose-response relationship and difficult to reproduce. The human performance or event related potentials (ERPs) measures that might specifically be affected by EMF exposure, as well as a possible cerebral structure or function that could be more sensitive to EMF, cannot be better determined. [less ▲]

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See detailNudging epidermal field cancerogenesis by imiquimod.
Uhoda, Isabelle; Quatresooz, Pascale ULiege; Pierard, Claudine ULiege et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(4), 357-60

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of ... [more ▼]

BACKGROUND: The coexistence of malignancies close to each other on the skin has been occasionally reported. The concept of field cancerogenesis applies to such cases. Given the purported mechanism of action of imiquimod, it should not be surprising that this treatment could inhibit epidermal field cancerogenesis. AIM: To assess the effect of imiquimod applied twice weekly on incipient bowenoid changes disclosed in the vicinity of basal cell carcinomas. MATERIALS AND METHOD: Biopsies were taken before treatment and after 4-6 weeks and 12 weeks of imiquimod treatment. RESULTS: Large atypical bowenoid keratinocytes and dyskeratotic cells were cleared in time while factor-XIIIa-positive dermal dendrocytes appeared boosted and admixed with a brisk lymphocytic infiltration. CONCLUSION: Epidermal field cancerogenesis appears to be controlled by imiquimod. Dermal dendrocytes might play a pivotal role in this regression phenomenon. [less ▲]

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See detailMilitantisme pas mort ?
Biquet, Véronique ULiege; Jacquemain, Marc ULiege; Stangherlin, Gregor

in Politique : Revue de Débats (2003), (29), 12-15

L'article reprend les thèses classiques sur la transformation du militantisme vers un engagement distancié (Ion) en montrant comment ces thèses peuvent s'appuyer sur les théories du postmatérialisme ... [more ▼]

L'article reprend les thèses classiques sur la transformation du militantisme vers un engagement distancié (Ion) en montrant comment ces thèses peuvent s'appuyer sur les théories du postmatérialisme (Inglehart). Il s'interroge aussi sur la capacité de l'altermondialisme, dans ce contexte, à constituer à terme une alternative au militantisme classique. [less ▲]

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See detailPour que le peuple lise : un siècle de lutte inachevée
Francis, Frédéric ULiege

in Les Cahiers d’Education permanente (2003), 19

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See detailDie Medien der Germanistik und die Nöte des Nachwuchses
Pontzen, Alexandra ULiege

in Jahrbuch der Deutschen Schillergesellschaft (2003), XLVII

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See detailElectromagnetic modes in dusty plasmas with charge and mass distributions
Verheest, F.; Cattaert, Tom ULiege

in Physics of Plasmas (2003), 10(4), 956-962

Electromagnetic modes in dusty plasmas are studied for polydisperse dust grains with a distribution in charge and mass. Owing to the different charge and mass weightings of the velocities, there occurs an ... [more ▼]

Electromagnetic modes in dusty plasmas are studied for polydisperse dust grains with a distribution in charge and mass. Owing to the different charge and mass weightings of the velocities, there occurs an infinite chain of equations of motion, coupled through the magnetic part of the Lorentz force. Depending on the frequency and associated convergence regimes, one has to close the chain in ascending or in descending order. Both series together lead to the polydisperse dispersion law that is a generalization of monodisperse or size distributed dust. Power-law distributions typical for heliospheric plasmas are discussed as an application. (C) 2003 American Institute of Physics. [less ▲]

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