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See detailComposition of the essential oil of Piper acutifolium Ruiz. and Pav. from Peru.
Lognay, Georges ULg; Bouxin, P.; Marlier, M. et al

in Journal of Essential Oil Research (1996), 8(6),

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See detailCase management voor psychogeriatrishe patiënten: gezondheidstoestand van deze ouderen en de zorgbelasting van hun centrale verzorgers
Milisen, K.; Borgermans, L.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

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See detailCes histoires que l'on construit et que l'on se raconte...
Guillaume, Jean-François ULg

in Cahiers Internationaux de Sociologie (1996), 100

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L ... [more ▼]

A partir des réflexions de Paul Ricoeur sur la temporalité et la narrativité, l'A. envisage les processus discursifs de construction identitaire chez les jeunes gens en fin de scolarité obligatoire. L'identité en construction est appréhendée à travers le récit qu'ils donnent de leurs projets d'avenir et de leur histoire familiale. La présentation de soi, perçue dans cette double dimension, est soumise à un ensemble de schèmes ou de modèles narratifs culturellement ancrés et socialement véhiculés. Elle prend forme et se constitue en une totalité cohérente et intelligible par une « mise en intrigue » de la diversité des péripéties vécues ou imaginées. [less ▲]

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See detailFalls among the elderly: a community problem
Reginster, Jean-Yves ULg; Gosset, Christiane ULg; Reginster-Haneuse, G.

in Archives of Public Health (1996), 54

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See detailReconnaissance des malformations et pathologies prénatales du système nerveux central
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia

in Acta Paediatrica Belgica (1996), 28(3), 204-215

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See detailLe diabete non insulinodependant: de la physiopathologie au traitement.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(7-9), 395-402402-5

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important ... [more ▼]

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important public health problem. This polygenic disease is often expressed late in life and its evolution is accelerated by environmental factors leading to obesity. It combines defects in both insulin secretion and insulin action, and such defects are present in various proportions according to the type of patient and the stage of the disease. Diet and physical activity recommendations are the basis of the treatment. Current pharmacological approaches aim at improving insulin secretion and/or insulin cellular action. After secondary failure to oral drugs, insulin therapy should be initiated, the patient becoming "insulin-requiring". A synergy should be searched in the combination of various therapeutic modalities in order to improve the glycaemic control. [less ▲]

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See detailMarsilio Ficino and Political Syncretism in Ian McEwan's Black Dogs
Delville, Michel ULg

in Notes on Contemporary Literature (1996), XXIV(3), 11-12

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See detailEffects of PEEP on abdominal aortic input impedance
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Intensive Care Medicine (1996), 22

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See detailField evaluation of pregnancy diagnosis using bovine pregnancy-associated glycoprotein (bPAG)
Skinner, J. G.; Gray, D.; Gebbie, F. E. et al

in Cattle Practice (1996), 4(3), 281-284

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See detailRelationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
Creuven, Isabelle; Evrard, Christine ULg; Olivier, Anne et al

in Antiviral Research (1996), 30

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the ... [more ▼]

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the different affinity of the compounds for the herpes simplex virus type 1 (HSV-1) thymidine kinase. These compounds present a variable affinity according to the position of the heteroatom substituting the five-membered ring. An unfavourable substitution in the five-membered ring for interaction with the HSV-1 thymidine kinase has been identified. [less ▲]

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See detailInterregional correlation of cerebral glucose metabolism in unmedicated schizophrenia
Biver, Françoise; Goldman, Serge; De Maertelaer, Viviane et al

in European Neuropsychopharmacology (1996), 6(2), 141-147

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in ... [more ▼]

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in 15 unmedicated schizophrenic patients and 15 healthy subjects. We analyzed correlations between glucose metabolism data of multiple brain regions using factorial analysis and correlation coefficient comparisons. Absolute regional intercorrelations in schizophrenic brains were found to be significantly stronger than in controls, in relationship to the greater variability of metabolic rates in schizophrenic patients. Variability of normalized metabolic rates and regional intercorrelations were not significantly different between schizophrenic patients and control subjects. We conclude that a global metabolic factor accounts for the variability of metabolic data in untreated schizophrenia. [less ▲]

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See detailA. Kastler (1902-1984)
Biémont, Emile ULg; Glansdorff, P.

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 131-149

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See detailLa pratique de la mise en observation psychiatrique
Boxho, Philippe ULg

in Revue Médicale de Liège (1996), 52

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See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

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See detailHistorical seismicity of the Strait of Dover–Pas de Calais
Melville, Charles; Levret, Agnès; Alexandre, Pierre ULg et al

in Terra Nova (1996), 8

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See detailPlace de la nalbuphine (Nubain) dans l'arsenal analgésique moderne
SENARD, Marc ULg; Tazarourte, K.; Darmon, P. L.

in Urgences médicales (1996), 15

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See detailPost-encephalitic extra-pyramidal syndrome associating akinesia and stereotyped movements responsive to L-dopa
Picard, F.; Hirsch, E.; Salmon, Eric ULg et al

in Revue Neurologique (1996), 152(4), 267-271

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See detailControl of chorionic obstructive pulmonary disease in the horse
Lekeux, Pierre ULg; Art, Tatiana ULg; Roberts, C.

in British Veterinary Journal (The) (1996), 152

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See detailFaded Dreams - M. Carnoy
Martiniello, Marco ULg

in New Community (1996), 22(3), 547-548

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See detailLes échouages de cétacés: une méprise magnétique?
Das, Krishna ULg

in Cahiers d'Ethologie (1996), 16(1), 126-130

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See detailThe relation of ventilatory failure to pulmonary, respiratory muscle and central nervous system disturbances in calves with an experimentally produced pneumonia
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1996), 115(3), 203-219

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a ... [more ▼]

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a period of 10 h. Measurements were made of inspired minute ventilation VE), ventilatory pattern [inspiratory time (TI), expiratory time (TE), respiratory rate (RR) and tidal volume (VT)], transdiaphragmatic pressure (Pdi), occlusion pressure at the airway opening 100 milliseconds after onset of inspiration (Pawo100ms), arterial blood gas tensions and pH and recorded diaphragmatic electromyogram (EMGdi) and rectal temperature (Tr). On and after the third hour after inoculation, the animals varied in respect of clinical signs, Tr, RR, VE, Pawo100ms/EMGdi, and arterial gases and pH. In benign cases, diminished alertness, laboured respiration and fall of arterial oxygen pressure (PaO2) worsened up to 7 h after inoculation, but then progressively improved, VE being maintained at approximately 150% baseline throughout the study (10 h). Neither arterial carbon dioxide pressure (PaCO2) nor pH was altered. Moderate cases resembled benign cases in respect of laboured respiration, VE, PaO2 and PaCO2; however, pH was at first maintained at preinoculation levels, but declined thereafter. In severe cases, the animals were drowsy between hours 3 and 7, and became comatose between hours 8 and 10; in contrast to both benign and moderate cases: (1) RR was reduced by hour 5, (2) there was no trend towards recovery of PaO2 and pH, (3) VE, Pdi, Pawo100ms and Pawo100ms/EMGdi were severely decreased, and (4) PaCO2 increased. These results suggest that pneumonia does not alter ventilatory neuromuscular pump function in calves, unless concomitant cardiovascular collapse occurs. It is not clear whether fatal ventilatory failure is caused mainly by deterioration in ventilatory muscle fibre processes or structures, altered central nervous system adjustment of ventilatory timing, or cardiovascular dysfunction. However, inspiratory pressures fall when excitation to the diaphragm is still growing, which suggests peripheral respiratory muscle fatigue. [less ▲]

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See detailBrain hypometabolism of glucose in anorexia nervosa: Normalization after weight gain
Delvenne, Véronique; Goldman, Serge; De Maertelaer, Viviane et al

in Biological Psychiatry (1996), 40(8), 761-768

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex ... [more ▼]

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex-matched healthy volunteers were used as controls. Both groups were scanned during rest, eyes closed and with low ambient noise. In absolute values, the underweight anorectic patients, when compared to control subjects, showed a global (p = 0.002) and regional (p ≤ 0.001) hypometabolism of glucose which normalized with weight gain. In relative values, no global difference could be assessed between underweight anorectic patients and controls but a trend can, nevertheless, be observed toward parietal and superior frontal cortex hypometabolism associated with a relative hypermetabolism in the caudate nuclei and in the inferior frontal cortex. After weight gain, all regions normalized for absolute and relative values, although a trend appears toward relative parietal hypometabolism and inferior frontal cortex hypermetabolism in weight gain anorectic patients. Absolute brain glucose hypometabolism might result from neuroendocrinological or morphological aspects of anorexia nervosa or might be the expression of altered neurotransmission following deficient nutritional state. As some differences exists in relative values in underweight patients and tend to persist in weight gain states, this could support a potential abnormal cerebral functioning, a different reaction to starvation within several regions of the brain or different restoration rates according to the region. [less ▲]

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See detailAlpha-MSH stimulates neurite outgrowth of neonatal rat corticospinal neurons in vitro.
Joosten, E. A.; Verhaagh, S.; Martin, Didier ULg et al

in Brain Research (1996), 736(1-2), 91-8

Peptides related to melanocortin (alpha MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in ... [more ▼]

Peptides related to melanocortin (alpha MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in vitro. Here we study the neurite outgrowth promoting effect of alpha-MSH on corticospinal (CS) neurons in vitro. Corticospinal neurons were identified in cell culture of neonatal rat cortex by immunostaining of cholera toxin subunit B (CTB), retrogradely transported from the cervical parts of the spinal cord. The CTB-immunoreactive neurons represent a small percentage (3-5%) of the total cell population after 72 h in vitro. The axons or dendrites of cortical and CTB-labelled layer V neurons were visualized using antibodies against axon- or dendrite-specific markers and measured using a semi-automatic quantification device. Here we report that alpha-MSH stimulates axonal as well as dendrite outgrowth from both total and CTB-labelled neurons with a bell-shape response curve. Axonal outgrowth of CTB-labelled neurons was dose-dependently stimulated with a maximal effect of 50% at 10(-10) M alpha-MSH. The maximal effect for stimulation of axon outgrowth for the total cortex population was observed at 10(-8) M alpha-MSH. In addition dendrite outgrowth of both total and CTB-labelled neurons is stimulated in a dose-dependent manner with maximal effects (varying between 46 and 48%) at 10(-8) M alpha-MSH. Explanations in the shift for the optimal alpha-MSH concentration for stimulation of axonal outgrowth of CTB-labelled layer V neurons as compared to total cortex neurons are discussed. [less ▲]

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See detailContrefaçons liégeoises et maestrichtoises de Beaumarchais. Un exercice bibliographique
Droixhe, Daniel ULg

in Bulletin de l'Institut Archéologique Liégeois (1996), 107

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See detailEnzymes from psychrophilic organisms
Feller, Georges ULg; Narinx, E.; Arpigny, J. L. et al

in FEMS Microbiology Reviews (1996), 18(2-3), 189-202

Psychrophilic organisms such as micro-organisms and other ectothermic species living in polar, deep- sea or any constantly low temperature environments, produce enzymes adapted to function at low ... [more ▼]

Psychrophilic organisms such as micro-organisms and other ectothermic species living in polar, deep- sea or any constantly low temperature environments, produce enzymes adapted to function at low temperature. These enzymes are characterized by a high catalytic efficiency at low and moderate temperatures but are rather thermolabile. Due to their high specific activity and their rapid inactivation at temperatures as low as 30 degrees C, they offer, along with the producing micro-organisms, a great potential in biotechnology. The molecular basis of the adaptation of cold cu-amylase, subtilisin, triose phosphate isomerase from Antarctic bacteria and of trypsin from fish living in North Atlantic and in Antarctic sea waters have been studied. The comparison of the 3D structures obtained either by protein modelling or by X-ray crystallography (North Atlantic trypsin) with those of their mesophilic counterparts indicates that the molecular changes tend to increase the flexibility of the structure by a weakening of the intramolecular interactions and by an increase of the interactions with the solvent. For each enzyme, the most appropriate strategy enabling it to accommodate the substrate at a low energy cost is selected. There is a price to pay in terms of thermosensibility because the selective pressure is essentially oriented towards the harmonization of the specific activity with ambient thermal conditions. However, as demonstrated by site-directed mutagenesis experiments carried out on the Antarctic subtilisin, the possibility remains to stabilize the structure of these enzymes without affecting their high catalytic efficiency. [less ▲]

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See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

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See detailInfluence of blanching on the quality of Brussels sprouts (Brassica oleracea L cv gemmifera).
Wathelet, Jean-Paul ULg; Mabon, N.; Foucart, M. et al

in Sciences des Aliments (1996), 16(4), 393-402

Blanching of Brussels sprouts before freezing induces chemical, enzymatical and physico-chemical modifications. This blanching study was made at three temperatures (in water at 90 degrees C and 95 degrees ... [more ▼]

Blanching of Brussels sprouts before freezing induces chemical, enzymatical and physico-chemical modifications. This blanching study was made at three temperatures (in water at 90 degrees C and 95 degrees C, in steam at 105 degrees C), The glucosinolate and glucose contents decrease when the technological treatment is extended. These losses are higher in water blanching, especially for external leaves, The myrosinase activity is reduced when treatment time and temperature increase. The peroxydase which is more thermoresistant than myrosinase is a good test for measuring inactivation of enzymes during the industrial blanching. Variations of the colour (green) are larger for external leaves than in the middle of the material. After two minutes of blanching, a hardening of Brussels sprouts is observed hut, after that time, the hardness decreases. [less ▲]

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See detailComplete Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome X
Galibert, F.; Alexandraki, D.; Baur, A. et al

in Embo Journal (1996), 15(9),

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See detailLa thermographie infrarouge dans l'étude de la thermorégulation chez le cheval : effets de l'entraînement
Ghafir, Y.; Art, Tatiana ULg; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1996), 140

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of ... [more ▼]

Thermography records radiant thermal emissions and represents thermal patterns of a body. The aim of this article was to study the training effects on thermoregulation in exercising horses, by means of measurements of rectal and skin temperature. The results have shown a smaller increase of rectal temperature and a greater increase of cutaneous temperature following a training period of 6 weeks. They suggest an improvement of thermoregulation via the skin. [less ▲]

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See detailEvaluation of insuline-like growth horme-I (IGF-I) and their binding proteins (IGFBPs) in pigs
Renaville, Robert ULg; Prandi, Alberto; Claes, Victor et al

in Archivio Veterinario Italiano (1996), 46

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See detail"Parce que je ne connais pas bien le grec..." (P. Col. Zen. II 66)
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1996), 71(142), 311-316

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See detailDetermination Of The Taxonomic Position And Characterization Of Yam Mosaic Virus Isolates Based On Sequence Data Of The 5'-Terminal Part Of The Coat Protein Cistron
Duterme, Olivier; Colinet, Dominique; Kummert, Jean et al

in Archives of Virology (1996), 141(6), 1067-1075

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See detailSelection and identification of lumped models of the arterial vasculature using multiple regression and backward elimination in the time domain
POCHET, T; GERARD, P; LAMBERMONT, Bernard ULg et al

in Medical & Biological Engineering & Computing (1996), 34

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See detailTheory of the thermal conductivity of metallic localized spin compounds in a magnetic field
Rassili, Ahmed ULg; Ausloos, Marcel ULg

in Journal of Magnetism & Magnetic Materials (1996), 163(1-2), 153-163

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint ... [more ▼]

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint impurity and phonon scattering processes together with the localized spin influence is shown. Remarkable features are found at low temperature and near the critical transition. An increase of conductivity with field near T-C is discussed. It is also argued that a coherent effect due to the field is the cause of the thermal conductivity enhancement at low temperature. The magneto-thermal conductivity is shown at different temperatures. [less ▲]

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See detailDu Dictionnaire général de la langue wallonne à l'Atlas linguistique de la Wallonie
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1996), 23-24

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See detailMarginalia Vergiliana
Rochette, Bruno ULg

in Zeitschrift für Papyrologie und Epigraphik (1996), 114

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See detailPharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Pharmacological Research (1996), 34(1-2), 9-10

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond ... [more ▼]

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond placed at the bottom of the U. This configuration is similar to that recently observed with the hypoglycaemic sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic agents of the meglitinide family, such as S3075, repaglinide, A-4166 and KAD-1229. The identification of a conformation common to these various hypoglycaemic drugs may provide an imprint of their binding site at the level of the B-cell sulphonylurea receptor. [less ▲]

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See detailEvaluation de l'effet apaisant d'un dermocosmétique: Soin intense apaisant
Nikkels, Arjen ULg; Jacquet, A.; Pierard, Gérald ULg

in Nouvelles Dermatologiques (1996), 15

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation ... [more ▼]

The aim of this study is to highlight the soothing effect of SOIN INTENSE APAISANT of Castalia on cutaneous lesion induced by UV radiation. For this prupose, both direct investigations (clinical valuation and sites chromametry) and indirect investigations (corneocyte harvesting and chromametric analysis) have been conducted. The excellent correlation between the results has lead us to prove a very obvious soothing effect of SOIN INTENSE APAISANT (care range Hydrocapteur of Castalia, Laboratoires Lavipharm). [less ▲]

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See detailEvaluation of the cranial rectus abdominus muscle pedicle flap as a blood supply for the caudal superficial epigastric skin flaps in dogs.
Degner, Daniel; Walshaw, Richard; Arnoczky, Steven et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1996), 25

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See detailFilmer la dissidence. L'écriture documentaire dans l'oeuvre des frères Dardenne
Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1996), 41(hiver), 29-33

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See detailVoici un livre qu'on dit imprimé à Liège: Le Code de la nature de Morelly
Droixhe, Daniel ULg

in Revue d'Histoire Littéraire de la France (1996), 96(5), 943-965

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See detailHydrodynamic simulations of galaxy formation .2. Photoionization and the formation of low-mass galaxies
Thoul, Anne ULg; Weinberg, D. H.

in Astrophysical Journal (1996), 465(2), 608-616

Photoionization by the high-redshift ultraviolet radiation background heats low- density gas before it falls into dark matter potential wells, and it eliminates the neutral hydrogen and singly ionized ... [more ▼]

Photoionization by the high-redshift ultraviolet radiation background heats low- density gas before it falls into dark matter potential wells, and it eliminates the neutral hydrogen and singly ionized helium that dominate cooling of primordial gas at temperatures of 10(4)-10(5) K. We investigate the influence of photoionization on galaxy formation using high-resolution simulations with a one-dimensional, spherically symmetric, Lagrangian hydrodynamics/gravity code. We find that the presence of a photoionizing background suppresses the formation of galaxies with circular velocities v(circ) less than or similar to 30 km s(-1) and substantially reduces the mass of cooled baryons in systems with circular velocities up to v(circ) similar to 50 km s(-1). Above v(circ) similar to 75 km s(-1), photoionization has no significant effect. Photoionization exerts its influence primarily by heating gas before collapse; the elimination of line cooling processes is less important. We discuss the implications of these results for hierarchical theories of galaxy formation. [less ▲]

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See detailNeurophysins in central diabetes insipidus
Legros, Jean-Jacques ULg; Geenen, Vincent ULg

in Hormone Research (1996), 45

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See detailSerum erythropoietin in chronic lymphocytic leukaemia.
Beguin, Yves ULg; Lampertz, S.; Bron, D. et al

in British Journal of Haematology (1996), 93(1), 154-6

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured ... [more ▼]

Anaemia is a frequent complication of advanced chronic lymphocytic leukaemia (CLL) and several cytokines known to inhibit erythropoietin (Epo) formation are produced by CLL B cells. Therefore we measured serum Epo levels in 47 CLL patients to determine whether Epo was a significant factor in the development of their anaemia. Epo levels were increased compared to normal individuals and this elevation appeared adequate for the degree of anaemia. The slope of the regression of Epo versus haemoglobin (Hb) was similar to that of a reference group. Serum transferrin receptor (sTfR) levels were also appropriately elevated for the degree of anaemia and correlated with serum Epo. Advanced stage was not associated with reduction of Epo production but diminished erythropoietic activity was observed in several patients. The results indicate that anaemia in CLL is not characterized by inadequate Epo production. [less ▲]

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See detailAcute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Louis, Renaud ULg; Radermecker, Maurice ULg

in European Respiratory Journal (1996), 9(7), 1414-20

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in ... [more ▼]

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in the specific conductance (sGaw) and forced expiratory volume in one second (FEV1) in 12 asthmatics and 12 normal subjects after inhalation of doubling doses of PAF (15-120 micrograms) and methacholine (18 to at least 144 micrograms). In order to take into account a possible tachyphylaxis, we compared PAF dose-response curves performed on one day with the curves obtained by giving the same doses separately on different days. Repeated inhalations of doubling doses of PAF caused sGaw and FEV1 to plateau after the second dose in each group, whereas methacholine provoked a dose-related decrease in sGaw and FEV1. A dose-dependent decrease in the functional indices was restored when the different doses of PAF were administered on separate days. In both groups, the fall in sGaw after inhalation of 60 micrograms as a single dose was higher than that achieved when this dose was given during a full bronchial challenge. The falls in sGaw and FEV1 after PAF inhalation were significantly higher in the asthmatics than in the normal subjects. The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). When the PD35,sGaw values were compared, PAF was found on a molar basis to be 33 fold more potent than methacholine in the normal subjects, but only fivefold more potent in the asthmatics (p < 0.05). The percentage falls in FEV1 (calculated by interpolation) for a 35% fall in sGaw, were greater in asthmatics than in normals both for methacholine (p < 0.05) and PAF (p = 0.09). Our results demonstrate a tachyphylaxis after inhalation of platelet-activating factor in normal subjects and asthmatics, and show that asthmatics develop a greater bronchial obstruction than normal subjects even if methacholine is more sensitive than platelet-activating factor at discriminating between the two groups. [less ▲]

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See detailErythropoietin and the anemia of cancer.
Beguin, Yves ULg

in Acta Clinica Belgica (1996), 51(1), 36-52

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation ... [more ▼]

The pathogenesis of the anemia of cancer involves the combination of a shortened erythrocyte survival in circulation with the failure of bone marrow to increase red cell production in compensation. Inappropriate red cell production is itself related to a conjunction of factors, including impaired availability of reticuloendothelial storage iron, inadequate erythropoietin (Epo) response to anemia, and overproduction of cytokines which are capable of inhibiting erythropoiesis. Many of these cytokines may interfere with erythropoietin production by the kidney. Consequently inadequate serum erythropoietin levels are often encountered in cancer patients, though more frequently in those with solid tumors or multiple myeloma than in those with other hematologic malignancies. There is little evidence supporting a negative impact of chemotherapy, including cisplatin, on erythropoietin production. Rather, chemotherapy usually causes a transient elevation of serum Epo. Red cell transfusions are often administered to cancer patients, possibly resulting, among other deleterious effects, in enhancement of tumor growth. Recombinant human erythropoietin (rHuEpo) has thus been proposed as an alternative. RHuEpo has been shown to be safe and effective in correcting the anemia of cancer and reducing the need for transfusions. The response rate is as good in hematologic malignancies as in solid tumors, but it is extremely poor in those with myelodysplastic syndromes. The effect of rHuEpo does not differ among patients receiving or not receiving chemotherapy, including cisplatin. The probability of response is also similar in patients with adequate or inappropriate erythropoietin production before therapy, although the doses used are usually 2 to 3 times higher than in renal failure patients. [less ▲]

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See detailMortality in Oryzaephilus surinamensis following short-term exposure to conditioned kernels by high-density culture
Mignon, Jacques ULg; Haubruge, Eric ULg; Lienard, Valérie et al

in Entomologia Experimentalis et Applicata (1996), 80(3), 555-557

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See detailEnergetic and conformational study of four benzylimidazole compounds with alpha 2 agonist profile: The mivazerol and three methylated derivatives
Vancampenhout, Nathalie; Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1996), 60(4), 911-930

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either ... [more ▼]

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either neutral or protonated, that could interact with the alpha 2 adrenoceptors. The solvent effect was also studied within the Onsager's solvent model at the two dielectric constant (epsilon) values of 4 and 80. The interaction with the environment (either solvent or receptor) is schematically studied by positioning either two water molecules or one formamide or/and one formic add near the amide and the imidazole for few isomers. The medium polarization, through epsilon, and the solvation effect, through the interaction with the solvent molecules or the receptor side chains, stabilize the same isomers. Post-SCF calculations are performed at the CISD level, the first excited singlet and triplet states energies are determined, and the question of the wave-function stability is addressed. The results indicate the probability of a spin-orbit coupling with the first excited triplet state, thus opening the question of such a possibility within an enzyme active site. (C) 1996 John Wiley & Sons, Inc. [less ▲]

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See detailPrognostic indices for mortality of hospitalized children in central Africa.
Dramaix, M.; Brasseur, D.; Donnen, P. et al

in American journal of epidemiology (1996), 143(12), 1235-43

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This ... [more ▼]

A hospital-based follow-up study was conducted between 1986 and 1988 at Lwiro (South Kivu Province, Zaire). Of 1,129 children in the study, three of four were severely malnourished, and 17.4% died. This study analyzes the mortality in hospital; its objectives are to evaluate the prognostic power of edema and anthropometric and biologic indicators and to seek indices that perform better. Receiver operating characteristic curves were established for each parameter under study and for each index constructed. Areas under receiver operating characteristic curves were highest for biologic indicators, and simple indices, obtained by counting the number of risk factors present, performed best. In the absence of biologic parameters, the authors suggest classifying children as at risk of dying when they present with edema and/or with arm circumference of less than 115 mm. When biologic measurements are possible, in addition to edema and arm circumference, the authors suggest taking serum albumin and transthyretin into account. For serum albumin and transthyretin, mortality risk is defined in terms of values of less than 16 g/liter and 6.5 mg/dl, respectively. Children will be classified as at risk of dying when they present with at least two of the four risk factors. The resulting diagnostic test has a high sensitivity (91.2%) and positive and negative predictive values of 40.8% and 97.9%, respectively. [less ▲]

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See detailSera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains.
Dehan, Pierre ULg; Weber, M.; Zhang, X. et al

in Nephrology Dialysis Transplantation (1996), 11(11), 2215-22

BACKGROUND: Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies ... [more ▼]

BACKGROUND: Goodpasture (GP) syndrome is defined by the clinical association of pulmonary haemorrhage with rapidly progressive glomerulonephritis. The disease is caused by pathogenic autoantibodies directed against type IV collagen, which is a major structural component of glomerular basement membranes (GBM). METHODS: The non-collagenous domains (NC1) of all six human type IV collagen alpha chains was produced in E. coli as recombinant fusion proteins with glutathione-S transferase. Sera from 10 patients with different types of anti-GBM nephritis, including GP syndrome, were tested for reactivity with the six proteins using immunoblotting of denatured and reduced proteins and ELISA without reduction. RESULTS: All 10 sera reacted with the alpha 3 (IV) collagen chain by immunoblotting and ELISA. One serum also recognized the alpha 2(IV), alpha 4(IV), alpha 5(IV) and alpha 6(IV) chains by immunoblotting. ELISA measurements revealed reactivity of several other sera with alpha 2(IV), alpha 4(IV) or alpha 6(IV) but not with alpha 5(IV) collagen chains. No reactivity was observed with the alpha 1(IV) chain. CONCLUSION: Autoantibodies in anti-GBM nephritis may not be directed only against the alpha 3(IV) collagen chain and they frequently recognize conformational epitopes. [less ▲]

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See detailPistoi Hermeneis. La traduction orale en Grèce
Rochette, Bruno ULg

in Revues des Etudes grecques (1996), 109(2), 325-347

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See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

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See detailAlteration of the endocrinological status of growing calves by a glucocorticoids treatment
Massart, Serge; Bertozzi, Carlo; Prandi, Alberto et al

in Journal of Animal Science (1996), 74(suppl 1), 230

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See detailStromelysin-3 expression promotes tumor take in nude mice
Noël, Agnès ULg; Lefebvre, O.; Maquoi, Erik ULg et al

in Journal of Clinical Investigation (1996), 97

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer experiments using both anti-sense and sense ST3 expression vectors, and malignant cells either expressing (NIH 3T3 fibroblasts) or not (MCF7 epithelial cells) endogenous ST3. We have compared the ability of parental and transfected cells to cause subcutaneous tumor development in nude mice. 3T3 cells expressing anti-sense ST3 RNA showed reduced tumorigenicity, and MCF7 cells expressing mouse or human ST3 were associated with reduced tumor-free period leading to a significant increased tumor incidence(P<10(-4)). However, once established, the ST3 expressing tumors did not grow faster than those obtained with the parental MCF7 cell line. In addition, tumors obtained after sub-cutaneous injection of ST3-expressing or nonexpressing cells did not exhibit obvious histological differences, and careful examination did not reveal any local invasive tissue areas nor systemic metastases. These in vivo observations were in agreement with those obtained in vitro showing that ST3 expression did not modify proliferative nor invasive properties of transfected cells. Altogether, these results indicate that ST3 expression promotes tumor take in nude mice, presumably by favoring cancer cell survival in a tissue environment initially not permissive for tumor growth. These findings represent the first experimental evidence showing that ST3 can modulate cancer progression. [less ▲]

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See detailA Generalized Method of Moving Asymptotes (GMMA) Including Equality Constraints
Zhang, Weihong; Fleury, Claude ULg; Duysinx, Pierre ULg et al

in Structural Optimization (1996), 12(2/3), 143-146

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See detailSemantic memory and amnesia: A case study
Van der Linden, Martial ULg; Brédart, Serge ULg; Depoorter, N. et al

in Cognitive Neuropsychology (1996), 13(3), 391-413

The performance of a severe amnesic patient (AC) was explored across two tasks designed to assess his public and personal semantic knowledge before and after the onset of his amnesia.

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See detailPostencephalitic stereotyped involuntary movements responsive to L-Dopa
Picard, F.; deSaintMartin, A.; Salmon, Eric ULg et al

in Movement Disorders (1996), 11(5), 567-570

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few ... [more ▼]

In 1954, at the age of 5 years, our patient had an encephalitic syndrome associated with a prolonged lethargic state. After this episode, he developed a severe parkinsonian syndrome that, after a few years, was associated with axial dystonia and stereotyped abnormal movements of the upper limbs. This complex and progressive extrapyramidal syndrome had many similarities to the encephalitis lethargica as described by von Economo. Results of cerebral computed tomography and magnetic resonance imaging were normal. Fluorodopa positron emission tomography showed a significant bilateral reduction of tracer accumulation in both putamen, similar to that observed in patients with idiopathic Parkinson's disease. However, in this patient, treatment with L-Dopa suppressed all akinetic, dystonic and dyskinetic symptoms. The effectiveness of L-Dopa was abolished by administration of a D2 antagonist and was fully reproduced by a D2 agonist. In conclusion, this patient presented a complex postencephalitic, extrapyramidal syndrome, with akinetic symptoms and involuntary movements. These symptoms appeared to be related to a limited lesion of the dopaminergic neurons of the zona compacta of the substantia nigra. [less ▲]

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See detailRelationships of polymorphisms for growth hormone and growth hormone receptor genes with milk production traits for Italian Holstein-Friesian bulls
Falaki, M.; Gengler, Nicolas ULg; Sneyers, M. et al

in Journal of Dairy Science (1996), 79(8), 1446-1453

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the ... [more ▼]

Allelic variation in the structural or regulatory sequences of growth hormone and its receptor genes might directly or indirectly affect milk traits. This possibility prompted us to investigate the eventual relationships of restriction fragment length polymorphisms at the locus of bovine growth hormone (using TagI and MspI restriction enzymes) and its receptor (using TaqI restriction enzyme) production traits of bulls. Holstein-Friesian bulls were used in this experiment, and data were analyzed with a fixed linear model. The restriction fragment length polymorphisms at the growth hormone locus did not affect the milk traits studied. Six restriction enzyme TaqI bands of 7.1, 6.2, 5.7, 5.4, 4.2, and 3.3 kb with nine patterns were observed after hybridization by a cDNA probe containing the coding sequences for the intracellular C-terminal part of the receptor. The effect of this polymorphism on PTA for milk protein percentage was highly significant and was favorable for the rare (6.6%) 5.7- and 5.4-kb pattern. Our results indicate that further study is needed to explain the DNA polymorphism and to obtain more definite conclusions about effects on milk traits. [less ▲]

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See detailSequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals
Goffin, VINCENT; Shiverick, KATHLEEN T; Kelly, PAUL A et al

in Endocrine Reviews (1996), 17(4), 385-410

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See detailInsulin action in man.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabètes & Métabolism (1996), 22(2), 105-10

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is ... [more ▼]

Insulin action is crucial for the regulation of glucose metabolism. Insulin plays a key role in suppressing endogenous glucose production by the liver, both in fasting and postprandial states. Insulin is also necessary for the maintenance of normal rates of glucose oxidation and storage in insulin-sensitive tissues and for the prevention of excessive gluconeogenic substrate production. Various methods have been developed to assess insulin action in vivo, essentially at liver and muscle sites. Such methods evaluate the effect of exogenous or endogenous insulin, using respectively the open-loop approach (interruption of the feedback loop by inhibiting endogenous insulin secretion) or the closed-loop approach (mathematical modelling of the insulin-glucose feedback loop). Knowledge of the successive steps of cellular insulin action has markedly improved during the last ten years. Preceptor, receptor and postreceptor levels need to be considered since they may be affected in insulin-resistant states. This general progress in the understanding of insulin action in man improves our approach to the complex pathophysiology of non-insulin-dependent diabetes mellitus and opens up new prospects for treatment of the insulin-resistant syndrome which is associated with several atherosclerotic risk factors. [less ▲]

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See detailIpriflavone in prevention and treatment of postmenopausal and senile osteoporosis
Reginster, Jean-Yves ULg

in Osteoporosis News (1996), 4

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See detailPhase transition and thermodynamics of a hot and dense system in a scaled NJL model
Cugnon, Joseph ULg; Jaminon, Martine ULg; Van den Bossche, Bruno

in Nuclear Physics A (1996), 598

he chiral phase transition of a hot and dense system of quarks is studied within a modified SU(3) NJL Lagrangian that implements the QCD scale anomaly. The u- and s-quark condensates can or can not feel ... [more ▼]

he chiral phase transition of a hot and dense system of quarks is studied within a modified SU(3) NJL Lagrangian that implements the QCD scale anomaly. The u- and s-quark condensates can or can not feel the same chiral restoration depending on the considered region of the three-dimensional space (Tc, muuc, musc). The temperature behaviour of the pressure and the energy and entropy densities of the u- and s-quark system is investigated. At high temperature, the non-vanishing bare s-quark mass only modifies slightly the usual behaviour associated with an ideal quark gas. [less ▲]

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See detailLa négation bn ... iwnA en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1996), 5

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See detailTreatment of gypsum waste in a two stage anaerobic reactor
Deswaef, Sophie; Salmon, Thierry ULg; Hiligsmann, Serge ULg et al

in Water Science & Technology (1996), 34(5-6), 367-374

The reduction of high concentrations of gypsum (up to 110 kg/m(3)) is investigated in a two stage immobilised cell bioreactor. The first stage is mainly colonised by a consortium of acidogenic bacteria ... [more ▼]

The reduction of high concentrations of gypsum (up to 110 kg/m(3)) is investigated in a two stage immobilised cell bioreactor. The first stage is mainly colonised by a consortium of acidogenic bacteria and sulphate reducing bacteria oxidising volatile fatty acids with more than 2 carbons (mainly, butyrate and propionate). The gypsum consumption rate is rather high (ii kg/m(3).day). Most of acetate remains unconverted in this first stage. It is partially converted in the second stage (residence time : 12 days) which is predominantly colonised by acetate oxidising bacteria The gypsum consumption rate is much lower than in the first stage : 3 kg/m(3).day. With both stages, it is possible to reach an almost complete conversion of gypsum with an overall capacity of 6.1 kg gypsum/m(3).day. We propose also a very simple model to describe the different transformation rates. It allows us to clearly identify the activity levels of the different types of sulphate reducing bacteria in both stages. Copyright (C) 1996 IAWQ. [less ▲]

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See detailEffect of some organophosphate insecticides on acetylcholinesterase of adult Coccinella septempunctata (Coccinellidae)
Bozsik, Andras; Haubruge, Eric ULg; Gaspar, Charles

in Journal of Environmental Science & Health. Part. B, Pesticides, Food Contaminants, & Agricultural Wastes (1996)

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See detailThymic insulin-like growth factors (IGFs) in man and in an animal model of autoimmune IDDM
Geenen, Vincent ULg; Achour, Imane; Kecha, Ouafae et al

in Diabetologia (1996), 39

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See detailcompte rendu de A. Fraschetti, Rome et le prince. Traduction française par V. Jolivet, Paris, 1994
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1996), 9

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See detailSecretion of leukemia inhibitory factor (LIF) by human endometrium alone
Plachot, Michèle; Godard, Anne; Geenen, Vincent ULg

in Human Reproduction (1996), 11

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See detailThe Neoproterozoic Pan-African basement from the Alpine Lower Danubian nappe system (South Carpathians, Romania)
Liégeois, Jean-Paul ULg; Berza, Tudor; Tatu, Mihai et al

in Precambrian Research (1996), 80

The South Carpathians, which were thrust to the Moesian platform in the Alpine orogeny (Late Cretaceous to Tertiary), include the Danubian nappe system. The Danubian pre-Alpine basement comprises two ... [more ▼]

The South Carpathians, which were thrust to the Moesian platform in the Alpine orogeny (Late Cretaceous to Tertiary), include the Danubian nappe system. The Danubian pre-Alpine basement comprises two Variscan nappes, each one made up of partially retrogressed amphibolite facies rocks intruded by granitoids and capped by an Ordovician-Devonian volcano-sedimentary cover. No lithological correlation can be established between the pre-Ordovician basements of these two units. The metamorphic basement from the first Variscan nappe, the Drãgºan Group, is composed of banded amphibolites with some augen and aluminous gneisses intruded by granodioritic to tonalitic plutons. The banded structure of the amphibolites, together with their geochemistry, suggests a volcano-sedimentary sequence. Zircon U-Pb data on an intercalated augen gneiss have given an age of 777 ± 3 Ma for the emplacement of the protolith of this gneiss. Nd model ages (TDM) for the amphibolites range from 717 Ma to 817 Ma. At 777 Ma, Nd values cluster is at +8.3 to +9.8 and Sr initial ratios range between 0.7007 and 0.7023, indicating an oceanic origin without continental crust contamination. Major and trace elements from the Drãgºan amphibolites consistently display an island arc signature, with three differentiation trends evolving from an early tholeiitic trend to a more differentiated low-K calc-alkaline one. The Drãgºan terrane is similar to the Early Pan-African juvenile terranes of the Sahara. The basement of the second Variscan nappe, the Lainici-Pãiuº Group, is made up of metasedimentary rocks (mainly quartzites, marbles and graphitic mica gneisses) cut by early leucogranitic dykes, medium-K calc-alkaline and alkali-calcic (mainly granitic) plutons, and late medium-K porphyry diorite dykes. This magmatism can be bracketed between 588 Ma and 567 Ma (U-Pb zircon ages). The best preserved pluton (Tismana, 567 Ma old), displays a composite alkali-calcic (very high-K calc-alkaline) magmatic sequence, ranging from gabbro-diorite to monzogranite, including an ultramafic pod. Ages and geochemical signatures resemble the Saharan Late Pan-African granitoids. The existence of Late Precambrian partly juvenile terrains is thus confirmed within the basement of South Carpathians, which renders then a segment of the European Alpine belt that can be successfully compared to the Pan-African Trans-Saharan belt. [less ▲]

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See detailDevelopment of thymus autografts under the kidney capsule in the pig: a new 'organ' for xenotransplantation
Lambrigts, Denis; Franssen, Colette ULg; Martens, Henri ULg et al

in Xenotransplantation (1996), 3

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See detailSuperconductivity fluctuation effects on the thermal conductivity of Bi2Sr2CaCu2O8
Houssa, M.; Bougrine, Hassan ULg; Stassen, S. et al

in Physical Review. B : Condensed Matter (1996), 54(10), 6885-6888

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional ... [more ▼]

The superconductivity fluctuation contribution kappa(B) to the thermal conductivity of a Bi2Sr1.8Ca1.2Cu2O8+y polycrystal is extracted from precise experimental data. The crossover from two-dimensional (2D) to 3D behavior theoretically predicted by Varlamov and Livanov is well marked. The crossover temperature T-VL and the amplitude of the fluctuation contribution lead to realistic values for the interlayer coupling energy J(C) and the transport relaxation time tau near T-c. [less ▲]

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See detailDifferential accumulation of mRNA for immediate early genes and heat shock genes in heart after ischaemic injury.
Plumier, Jean-Christophe ULg; Robertson, H. A.; Currie, R. W.

in Journal of Molecular and Cellular Cardiology (1996), 28(6), 1251-60

Ischaemic injury leads to the expression of heat shock and immediate early genes. Here the localization of this induction is examined by in situ hybridization analysis in serial sections of buffer ... [more ▼]

Ischaemic injury leads to the expression of heat shock and immediate early genes. Here the localization of this induction is examined by in situ hybridization analysis in serial sections of buffer-perfused isolated rat heart after 30 min of coronary artery occlusion. The accumulation of mRNA for hsc70, hsp70, c-fos, c-jun, and Erg-1 was localized coincidently and was restricted to the ischaemic area of the heart. mRNA for these genes was undetectable at the end of the ischaemic period (no reperfusion). After 30 min of reperfusion, accumulation of mRNA for hsc70, hsp70, c-fos, and c-jun was detectable and increased with further reperfusion. Within the area labelled for these gene products was a central area of less intense labelling which corresponded to the necrotic zone. The immediate early gene product, jun-B, was localized in both the ischaemic and the non-ischaemic area of the hearts. These results suggest that the area of the heart where heat shock and immediate early gene transcripts accumulate, while injured, recovers transcriptional activity, and that the central area where minimal heat shock and immediate early gene transcripts accumulate, does not recover transcriptional activity and is irreversibly injured. [less ▲]

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See detailSuicidal behavior in depressive disorder: an event-related potential study.
Hansenne, Michel ULg; Pitchot, William ULg; Gonzalez Moreno, A. et al

in Biological Psychiatry (1996), 40(2), 116-22

P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results showed a significant reduction of P200, P300, and CNV and a ... [more ▼]

P300 and contingent negative variation (CNV) were recorded in depressive inpatients with and without history of suicide attempt. The results showed a significant reduction of P200, P300, and CNV and a significant increase of postimperative negative variation (PINV) in patients who had attempted suicide compared to patients with a negative history. Moreover, P300 amplitude was negatively related with the Suicidal Risk and the Hopelessness but not with the Hamilton scales. These results stress the need to differentiate clinical subgroups of patients to assess the psychophysiology of depression, and indicate that patients who attempted suicide exhibit lower cortical resources and poorer cortical performance than patients without history of suicide attempt. [less ▲]

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See detailImmunoreactive levels of α-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1
Mastrogiacomo, Frank; LaMarche, Jacques; Dozic, Slobodan et al

in Neurodegeneration : A Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration (1996), 5

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See detailOpera Latina, le CD-ROM de textes latins classiques du LASLA
Purnelle, Gérald ULg

in Le Médiéviste et l’Ordinateur (1996), 33(printemps), 21-25

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See detailGrowth features and intergranular connectivity of melt processed YBCO
Lo, W.; Dewhurst, C. D.; Cardwell, D. A. et al

in Applied Superconductivity (1996), 4(10-11), 507-517

Large grain melt processed Y-Ba-Cu-O (YBCO) samples have been prepared by seeded and unseeded growth techniques. The current carrying ability within individual grains and across grain boundaries has been ... [more ▼]

Large grain melt processed Y-Ba-Cu-O (YBCO) samples have been prepared by seeded and unseeded growth techniques. The current carrying ability within individual grains and across grain boundaries has been investigated and correlated with features in the microstructure of samples fabricated by both techniques. The development of an inhomogeneous, cell-like growth microstructure in seeded samples at distances = 4 mm from the seed is related to a Saturation in inclusion density and volume proportion of Y2BaCuO5 (Y211) particles. A significant decrease in critical current density is associated with this change over a wide temperature range. The resistance of high angle c-axis grain boundaries is observed to depend critically on the magnitude of the injection current whereas the intragranular resistance is not influenced significantly by this variable. Jc of a grain boundary fabricated by unseeded melt growth is estimated to be less than 100 A cm(-2) at 77 K in zero applied field, which is more than two orders of magnitude lower than the intragranular Jc. Field screening measurements suggest that low angle grain boundaries do not form weak links between grains in modest magnetic fields and hence do not present a significant barrier to current flow. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPerson familiarity and name-retrieval failures: How they are related ?
Brédart, Serge ULg

in Current Psychology of Cognition [=CPC] = Cahiers de Psychologie Cognitive [=CPC] (1996), 15(1), 113-119

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See detailEtude de la fiabilité d'un nouvel analyseur de lactate portable chez le cheval
Meynie, J.; Art, Tatiana ULg; Olaerts, J. et al

in Pratique Vétérinaire Equine (1996), 28(1), 37-40

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples ... [more ▼]

A new portable lactate analyzer has been tested for its accuracy and reproducibility. Venous blood has been sampled on 12 horses while they were performing a treadmill exercise. A total of 134 samples were obtained and analyzed either with the portable analyzer or with a reference method. The packed cell volume has been also determined for each sample. The results obtained with both methods were compared : the correlation between the two sets of data was satisfactory ((R2 = 0,86) but higher when the PCV was lower or equal to 55 % (R2 = 0,88). It was concluded that the portable analyzer is reliable for lactate determination in horses [less ▲]

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See detailMagnetic texturing of bulk samples of the superconductor Bi2Sr2Ca0.8Dy0.2Cu2O8-y
Stassen, Sophie; Rulmont, André ULg; Vanderbemden, Philippe ULg et al

in Journal of Applied Physics (1996), 79(1), 553-555

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are ... [more ▼]

The texturing process of Bi-Sr-Ca(Dy)-Cu-O (2212) is optimized by sintering under a magnetic field. The precursor crystalline powder is melted and grown under a 1.2 T magnetic field. Textured samples are characterized by x-ray diffraction, scanning electron microscopy, electrical resistivity, and magnetic susceptibility. (C) 1996 American Institute of Physics. [less ▲]

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See detailAu-delà du principe de répétition
Gauthier, Jean-Marie ULg

in Revue Belge de Psychanalyse (1996), 28

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See detailComparison of some modules of the Lie algebra of vector fields
Lecomte, Pierre ULg; Mathonet, Pierre ULg; Tousset, E.

in Indagationes Mathematicae (1996), 7(4), 461-471

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See detailLipid-binding properties of synthetic peptide fragments of human apolipoprotein A-II.
Benetollo, C.; Lambert, Géraldine ULg; Talussot, C. et al

in European Journal of Biochemistry (1996), 242(3), 657-64

Human apolipoprotein A-II (apo A-II) consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein. The conformation and ... [more ▼]

Human apolipoprotein A-II (apo A-II) consists of three potential amphipathic helices of 17 residues each, which contribute to the lipid-binding properties of this apolipoprotein. The conformation and lipid-binding properties of these peptides, either as single-helix or as two-helix peptides, were investigated by turbidity, fluorescence, electron-microscopy and circular-dichroism measurements, and are compared in this article. The lipid affinity of shorter C-terminal segments of apo A-II was compared with those of the single-helix or two-helix peptides, to define the minimal peptide length required for stable complex formation. The properties of the apo-A-II-(13-48)-peptide were further compared with those of the same segment after deletion of the Ser31 and Pro32 residues, because the deleted apo-A-II-(13-30)-(33-48)-peptide, is predicted to form a long uninterrupted helix. The single helices of apo A-II could not form stable complexes with phospholipids, and the helix-turn-helix segment spanning residues 13-48 was not active either. The apo-A-II-(37-77)-peptide and the apo-A-II-(40-73)-peptide could form complexes with lipids, which appear as discoidal particles by negative-staining electron microscopy. The shortest C-terminal domain of apo A-II able to associate with lipids to form stable complexes was the apo-A-II-(40-73)-peptide, which consisted of the C-terminal helix, a beta-turn and part of the preceding helix. The shorter apo-A-II-(49-77)-peptide, and the helical apo-A-II-(13-30)-(33-48)-peptide, could also associate with phospholipids. The complexes formed were, however, less stable, as they dissociated outside the transition temperature range of the phospholipid. These data suggest that the C-terminal pair of helices of apo A-II, which is the most hydrophobic pair, is responsible for the lipid-binding properties of the entire protein. The N-terminal pair of helices of apo A-II at residues 13-48 does not associate tightly with lipids. The degree of internal similarity and the cooperativity between the helical segments of apo A-II is thus less pronounced than in apo A-I or apo A-IV. The N-terminal and C-terminal domains of apo A-II appear to behave as two distinct entities with regard to lipid-protein association. [less ▲]

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See detailField percolation and high current density in 80/20 DyBa2Cu3O7-x/Dy2BaCuO5 bulk magnetically textured composite ceramics
Cloots, Rudi ULg; Dang, An; Vanderbemden, Philippe ULg et al

in Zeitschrift Fur Physik B-Condensed Matter (1996), 100(4), 551-555

We measured the AC susceptibility of magnetically textured (123) 80%/211(20%) DyBaCuO composite in a special set-up in order to enhance the intergrain contribution. The synthesis process led to very clean ... [more ▼]

We measured the AC susceptibility of magnetically textured (123) 80%/211(20%) DyBaCuO composite in a special set-up in order to enhance the intergrain contribution. The synthesis process led to very clean ''weak links'' at grain boundaries. At the percolation threshold bulk shielding paths were such that the intergrain critical current density J(c) was above 10(5) A/cm(2). The field dependence of J(c) was understood through an analytical form indicating a distribution of currents similar to the law of clusters at fracture/percolation thresholds. [less ▲]

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See detailL’ostéomalacie : étiologie, clinique, physiopathologie et thérapeutique
Reginster, Jean-Yves ULg

in Le Monde Médical de la Femme (1996), 330(23), 18-21

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See detailCompte-rendu de Pascal Engel, Philosophie et psychologie
Leclercq, Bruno ULg

in Revue Philosophique de Louvain (1996), 94

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See detailHigh prevalence of cardiovascular risk factors in children from the Belgian Luxembourg province. The Belgian Luxembourg Child Study.
Guillaume, Michèle ULg; Lapidus, L.; Beckers, F. et al

in American Journal of Epidemiology (1996)

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See detailGuidelines for authors of medical scientific manuscripts.
Detry, Olivier ULg; Van Damme, Hendrik ULg; Van de Stadt, J.

in Acta Chirurgica Belgica (1996), 96(4), 140-3

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See detailLes adénomes gonadotropes
Beckers, Albert ULg; Stevenaert, Achille ULg

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1996), 37(4-5), 299-305

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait ... [more ▼]

Les adénomes hypophysaires gonadotropes qui sont parmi les plus fréquents, ont été identifiés récemment; on estime aujourd'hui qu'environ 80 % des adénomes hypophysaires dits non-sécrétants sont en fait gonadotropes. Étant donné l'absente de symptomatologie spécifique, ils ne sont souvent reconnus que lorsqu'ils sont volumineux, ayant déjà entraîné un syndrome neurologique, une compression du chiasma optique. Dans la plupart des cas il est possible de les identifier grâce aux produits de sécrétion ou encore par méthodes d'immunohistochimie ou encore par la détection de l'ARN messager correspondant aux sous-unités hormonales. Le traitement reste essentiellement neuro-chirurgical (chirurgie trans-sphénoidale) car, dans la plupart des cas, les agonistes dopaminergiques et les analogues agonistes ou antagonistes de GnRH sont inefficaces. [less ▲]

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See detailDesign and modeling of new platelet-activating factor antagonists.2. Synthesis and biological activity of 1,4-bis-(3',4',5'-trimethoxybenzoyl)-2-alkyl and 2-alkoxymethylpiperazines
Tavet, Fabrice; Lamouri, Aazdine; Heymans, Françoise et al

in Journal of Lipid Mediators and Cell Signalling (1996), 15

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