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See detailCrossing of two mobile averages: A method for measuring the roughness exponent
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1998), 58(5), 6832-6834

Self-affine signals characterized by a defined Hurst (roughness) exponent H can be investigated through mobile averages. The density rho of crossing points between any two moving averages is a measure of ... [more ▼]

Self-affine signals characterized by a defined Hurst (roughness) exponent H can be investigated through mobile averages. The density rho of crossing points between any two moving averages is a measure of long-range power-law correlations in the signal. The method is compared to the detrended fluctuation analysis. We rake advantage of our findings in order to propose a practically powerful and accurate technique for determining H and apply it right away to cases with persistent or antipersistent correlations. [less ▲]

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See detailVaricella-zoster virus IE63, a virion component expressed during latency and acute infection, elicits humoral and cellular immunity
Sadzot-Delvaux, Catherine ULg; Arvin, Ann M.; Rentier, Bernard ULg

in Journal of Infectious Diseases (1998), 178(Suppl. 1), 43-47

Varicella-zoster virus (VZV) latency in human dorsal root ganglia is characterized by the transcription of large regions of its genome and by the expression of large amounts of some polypeptides, which ... [more ▼]

Varicella-zoster virus (VZV) latency in human dorsal root ganglia is characterized by the transcription of large regions of its genome and by the expression of large amounts of some polypeptides, which are also expressed during lytic cycles. The immediate early 63 protein (IE63) is a virion component expressed very early in cutaneous lesions and the first viral protein detected during latency. Immune response against IE63 has been evaluated among naturally immune adults with a history of chickenpox: Specific antibodies were detected in serum, and most subjects who had a T cell proliferation with unfractionated VZV antigens had T cell recognition of purified IE63. The cytotoxic T cell (CTL) response to IE63 was equivalent to CTL recognition of IE62, the major tegument component of VZV, whose immunogenicity has been previously described. T cell recognition of IE63 and other VZV proteins is one of the likely mechanisms involved in controlling VZV reactivation from latency. [less ▲]

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See detailLes effets de l'induction du travail sur le déroulement de l'accouchement
Gucciardo, L.; Thoumsin, H.; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1998), 53(11), 665-8

Labour induction has become a common practice. Given the significant number of induced deliveries carried out each year, it is important to know the consequences of this induction policy. The effects of ... [more ▼]

Labour induction has become a common practice. Given the significant number of induced deliveries carried out each year, it is important to know the consequences of this induction policy. The effects of labour induction on the childbirth are still the subject of considerable controversy. The increase of the caesarean and instrumental extraction rates has already been emphasized in previous studies. This article is based on an analysis of 10,045 deliveries carried out in the CHR Obstetrical Clinic of La Citadelle, between 1991 and 1997. The conclusions are instructive. Thus a departmental policy of setting an induction level of 35% will allocate 2/3 of the workload between 8:00 AM and 8:00 PM during the week, with a preponderance on Friday. The Caesarean rate is not increased but peridurals and recourse to instrumental extraction are more frequent. [less ▲]

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See detailCultured Oligodendrocyte Progenitors Derived from Cerebral Cortex Express a Glycine Receptor Which Is Pharmacologically Distinct from the Neuronal Isoform
Belachew, Shibeshih ULg; Rogister, Bernard ULg; Rigo, Jean-Michel et al

in European Journal of Neuroscience (1998), 10(11), 3556-64

Using the whole-cell patch-clamp technique, we demonstrate glycine-induced currents in oligosphere-derived oligodendrocyte progenitors cultured from newborn rats. Similar inward currents are also ... [more ▼]

Using the whole-cell patch-clamp technique, we demonstrate glycine-induced currents in oligosphere-derived oligodendrocyte progenitors cultured from newborn rats. Similar inward currents are also triggered by beta-alanine and taurine, two established glycine receptor agonists. In our recording conditions, glycine-gated currents in oligodendrocyte progenitors reverse about 0 mV and are reversibly inhibited by the glycine competitive antagonist strychnine, the Cl- channel blocker picrotoxinin and the non-competitive antagonist cyanotriphenylborate. The oligodendrocyte progenitors glycine receptor (GlyR) differs from the corresponding neuronal receptor: [3H]strychnine binding data and the strychnine inhibition curve of glycine-induced currents in oligodendrocyte progenitor cultures suggest the existence of two strychnine binding sites on the oligodendroglial GlyR. Using total RNA isolated from oligodendrocyte progenitors cultures, reverse transcription-polymerase chain reaction analysis of glycine receptor subunit expression shows the presence of alpha2 and beta subunits and immunocytochemical stainings confirm that this GlyR contains an alpha subunit which is not alpha1. The molecular structure of the oligodendroglial GlyR could be either homopentameric alpha2 or heteromeric alpha2beta but in both cases, the sequence of the alpha2 or beta subunits have to be different from the known neuronal sequences in order to explain, respectively, the cyanotriphenylborate (alpha2) and picrotoxinin (beta) sensitivities. This work thus demonstrates that GlyR are expressed by oligodendrocytes obtained not only from spinal cord but also from supraspinal structures. The pharmacological properties and presumably the molecular structure of oligodendroglial GlyR are original. The physiological meaning of the presence of such receptors on developing and mature oligodendrocytes remains unknown. [less ▲]

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See detailEvaluation of a Diphenylphosphorylazide-Crosslinked Collagen Membrane for Guided Bone Regeneration in Mandibular Defects in Rats
Zahedi, Sharam ULg; Legrand, Roman ULg; Brunel, G. et al

in Journal of Periodontology (1998), 69(11), 1238-46

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of ... [more ▼]

In the present study, the potential of a diphenylphosphorylazide-crosslinked type I bovine collagen membrane was evaluated in the healing of mandibular bone defects applying the biological concept of guided bone regeneration. The experiment was carried out on 25 Wistar rats. After exposing the mandibular ramus bilaterally, 5 mm diameter full-thickness circular bone defects were surgically created. While the defect on one side was covered by the membrane (experimental), the defect on the other side was left uncovered (control) before closure of the overlying soft tissues. The rats were sacrificed in groups of 5 after 7, 15, 30, 90, and 180 days of healing. Although at early stages of healing similar amounts of bone formation were observed in the experimental and control defects, after 1 month of healing, most of the experimental defects were completely closed with new bone, while in the control defects, only limited amounts of new bone were observed at the rims and in the lingual aspect of the lesions. In the 90- and 180-day animals, all experimental defects were completely closed, while in the control defects, no statistically significant increase in bone regeneration was observed. The increase in percentage of bone regeneration in the experimental defects was statistically significant between the 15-day specimens as compared with the 7-day specimens (P < 0.01) and likewise between 30-day and 15-day specimens (P < 0.001). It can be concluded that a DPPA-crosslinked collagen membrane yields biocompatibility, ad hoc mechanical hindrance, and handling characteristics suitable for guided bone regeneration applications in this experimental model. [less ▲]

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See detailTransmission and confocal fluorescence microscopy and time-resolved fluorescence spectroscopy combined with a laser trap: investigation of optically trapped block copolymer micelles
Gensch, Thomas; Hofkens, Johan; van Stam, Jan et al

in Journal of Physical Chemistry B (1998), 102(43), 8440-8451

Optical trapping was combined with transmission microscopy (TM), confocal and nonconfocal fluorescence scanning microscopy (CFSM and FSM, respectively), and confocal and nonconfocal time-resolved ... [more ▼]

Optical trapping was combined with transmission microscopy (TM), confocal and nonconfocal fluorescence scanning microscopy (CFSM and FSM, respectively), and confocal and nonconfocal time-resolved fluorescence spectroscopy (CTRFS and TRFS, respectively) to study latex particles and block copolymer micelles. Dye-labeled latex particles of various size, in polymer composite films as well as optically trapped in solution, were studied with CFSM to characterize the limits of the setup. CFSM revealed that the resolution in the x- and y-directions was near the theoretical limit, i.e., 200−250 nm. CTRFS on the labeled latex particles revealed that the decay time of the label was not influenced by the polymer matrix nor the optical trap. Poly(tert-butylstyrene-block-sodium methacrylate) micelles (diameter approximately 30−40 nm) in deuterated aqueous solutions could be optically trapped, this region of high copolymer micelle concentration being referred to as a trapped cluster. In the transmission images, trapped clusters of 1.5−2 μm diameter were detected. Fluorescence images were obtained using perylene as a fluorophore that is specifically dissolved within the block copolymer micelles. The size of the trapped cluster, estimated from TM and FSM images, increases with increasing irradiation time and power, respectively. In the TM images, the trapped cluster appears as a dark spot (low transmission) with a bright (high transmission) corona-like ring around it. The appearance of the corona is explained as a light deflection phenomenon; i.e., the trapped cluster acts as lens due to a lateral refractive index gradient. When the corona is taken into account when the diameter of the trapped clusters is calculated, a very good agreement is found between TM and FSM. Long irradiation times lead to the formation of large trapped clusters, which are stable for about 10 s, with diameters of several hundred nanometers, while, for short irradiation times, the trapped cluster is smaller and disappears within a time less than 1 s. With CFSM it could be shown that the trapped particle has a spot size of approximately 1.7 μm in the region of the IR laser focus, while the diameter extends up to 5 μm without using the confocal imaging capability. The reason for this is that the conditions for optical trapping are fulfilled not only in but also above and below the focal region. Due to the high numerical aperture, a dumbbell-like shape of the trapped cluster results. [less ▲]

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See detailFgf-3 and Fgf-4 Elicit Distinct Oncogenic Properties in Mouse Mammary Myoepithelial Cells
Hajitou, Amin; Baramova, Eugénia; Bajou, Khalid ULg et al

in Oncogene (1998), 17(16), 2059-71

Fibroblast Growth Factors 3 (FGF-3) and 4 (FGF-4) were compared for the effects they each exert on EF43 mouse cells. This non-transformed mammary cell line appears to be myoepithelial mainly because it ... [more ▼]

Fibroblast Growth Factors 3 (FGF-3) and 4 (FGF-4) were compared for the effects they each exert on EF43 mouse cells. This non-transformed mammary cell line appears to be myoepithelial mainly because it expresses alpha-smooth muscle actin. The EF43 cells were infected with similar vectors that carry either the short fgf-3 sequence (the product of which goes into the secretory pathway), fgf-4 or the selection gene only as control. In syngeneic animals, EF43.fgf-3 cells were tumorigenic only when orthotopically implanted whereas EF43.fgf-4 cells invariably gave rise to aggressive tumors. However, both tumor types were metastatic as evidenced by the blue micrometastases observed when the implanted cells expressed lacZ. In vitro, the FGF-3 producing cells were strongly invasive in matrigel coated chambers whereas the EF43.fgf-4 cells only were invasive in type I-collagen gels. Interestingly, FGF-3 production greatly stimulated the synthesis of pro-MMP-9 (Matrix Metalloprotease-9) and, to a lesser extent, that of pro-MMP-2. FGF-3 also up-regulated the production of plasminogen activators. In contrast, FGF-4 had no effect on these secretions and the medium conditioned by the EF43.fgf-4 cells displayed the largest plasminogen activator-inhibitor activity. These results show that FGF-3 and FGF-4 have distinct mechanisms of action on myoepithelial cells. [less ▲]

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See detailInvestigation of methyl methacrylate and vinyl acetate polymerization promoted by Al(iBu)3/2,2'-bipyridine and Al(iBu)3/2,2'-bipyridine/TEMPO complexes
Granel, Claude; Jérôme, Robert ULg; Teyssié, Philippe et al

in Macromolecules (1998), 31(21), 7133-7141

Results of methyl methacrylate (MMA) and vinyl acetate (VOAc) polymerization using the Al(iBu)3/2,2‘-bipyridine/TEMPO initiating system at room temperature failed to confirm the “living” radical mechanism ... [more ▼]

Results of methyl methacrylate (MMA) and vinyl acetate (VOAc) polymerization using the Al(iBu)3/2,2‘-bipyridine/TEMPO initiating system at room temperature failed to confirm the “living” radical mechanism reported earlier. Several species apparently propagate without control in a normal free radical process and only above a critical initiator concentration. No evidence was found for the penta- and hexacoordinated aluminum species previously suggested, but high conversion to an alkoxyamine was observed. Additionally, mixing Al(iBu)3 and BIPY promotes a variety of reactions involving alkyl and hydride transfers to the aromatic rings forming reduced BIPY products, along with a persistent organoaluminum radical. All these results illustrate that the process is considerably more complicated than postulated before. Conversely, at −78 °C, a single active species excluding the participation of TEMPO has been put in evidence, displaying some “living” characteristics. Several experiments support its anionic nature, as previously suggested by Ikeda. [less ▲]

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See detailTnf-Alpha and Ifn-Gamma Down-Regulate the Expression of the Metastasis-Associated Bi-Functional 37lrp/P40 Gene and Protein in Transformed Keratinocytes
Clausse, Nathalie; van den Brûle, Frédéric; Delvenne, Philippe ULg et al

in Biochemical and Biophysical Research Communications (1998), 251(2), 564-9

The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning ... [more ▼]

The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-alpha and IFN-gamma. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-gamma and TNF-alpha anticancerous action. [less ▲]

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See detailCarbon Dioxide Emission from European Estuaries
Frankignoulle, Michel; Abril, Gwenaël; Borges, Alberto ULg et al

in Science (1998), 282(5388), 434-6

The partial pressure of carbon dioxide (pCO2) in surface waters and related atmospheric exchanges were measured in nine European estuaries. Averaged fluxes over the entire estuaries are usually in the ... [more ▼]

The partial pressure of carbon dioxide (pCO2) in surface waters and related atmospheric exchanges were measured in nine European estuaries. Averaged fluxes over the entire estuaries are usually in the range of 0.1 to 0.5 mole of CO2 per square meter per day. For wide estuaries, net daily fluxes to the atmosphere amount to several hundred tons of carbon (up to 790 tons of carbon per day in the Scheldt estuary). European estuaries emit between 30 and 60 million tons of carbon per year to the atmosphere, representing 5 to 10% of present anthropogenic CO2 emissions for Western Europe. [less ▲]

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See detailPositive parity pentaquarks in a Goldstone boson exchange model
Stancu, Floarea ULg

in Physical Review. D : Particles and Fields (1998), D58

We study the stability of the pentaquarks $uudd\overline{Q}$, $uuds\overline{Q}$ and $udss\overline{Q}$ ($Q = c$ or $b$) of positive parity in a constituent quark model based on Goldstone boson exchange ... [more ▼]

We study the stability of the pentaquarks $uudd\overline{Q}$, $uuds\overline{Q}$ and $udss\overline{Q}$ ($Q = c$ or $b$) of positive parity in a constituent quark model based on Goldstone boson exchange interaction between quarks. The pentaquark parity is the antiquark parity times that of a quark excited to a p-shell. We show that the Goldstone boson exchange interaction favors these pentaquarks much more than the negative parity ones of the same flavour content but all quarks in the ground state. We find that the nonstrange pentaquarks are stable against strong decays. [less ▲]

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See detailAcromégalie : Examens complémentaires
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 51

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See detailX-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity
Swaren, Peter; Maveyraud, Laurent; Raquet, Xavier et al

in Journal of Biological Chemistry (1998), 273(41), 26714-26721

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See detailAcromegalie : Onderzoeken
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 51

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See detail4-Methoxypyridine N-Oxide: a new regulator for the controlled free radical polymerization of methyl methacrylate
Detrembleur, Christophe ULg; Lecomte, Philippe ULg; Caille, Jean-Raphaël et al

in Macromolecules (1998), 31(20), 7115-7117

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See detailAcromégalie : Diagnostic différentiel
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 50

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See detailElectrochemical synthesis of polypyrrole nanowires
Jérôme, Christine ULg; Jérôme, Robert ULg

in Angewandte Chemie (International ed. in English) (1998), 37(18), 2488-2490

Through a hole in a poly(ethyl acrylate) (PEA) layer that is electrochemically grafted to the surface of a vitreous carbon electrode-that is the route that must be taken by a growing polypyrrole nanowire ... [more ▼]

Through a hole in a poly(ethyl acrylate) (PEA) layer that is electrochemically grafted to the surface of a vitreous carbon electrode-that is the route that must be taken by a growing polypyrrole nanowire in the electropolymerization of pyrrole. Chain growth is controlled by diffusion of the monomer through the DMF-swollen PEA layer, which acts as a template for the formation of nanowires (shown in the picture) with diameters of 400-1000 nm and lengths of up to 300 m. [less ▲]

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See detailAcromegalie : Differentiaal-diagnose
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 50

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See detailCyclical Spectral and Photometric Variations of the Apparently Single Wolf-Rayet Star WR 134
Morel, Thierry ULg; Marchenko, S. V.; Eenens, P. R. J. et al

in Astrophysics & Space Science (1998), 260

Evidence is presented for the existence of a 2.3 day periodicity in the line-profile changes of the apparently singleWolf-Rayet star WR 134. This cyclical variability may be induced either by the presence ... [more ▼]

Evidence is presented for the existence of a 2.3 day periodicity in the line-profile changes of the apparently singleWolf-Rayet star WR 134. This cyclical variability may be induced either by the presence of an orbiting collapsed companion, or by the rotational modulation of a largely inhomogeneous outflow. [less ▲]

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See detailMolecular Cloning of a Mutated Hoxb7 Cdna Encoding a Truncated Transactivating Homeodomain-Containing Protein
Chariot, Alain ULg; Senterre-Lesenfants, Sylviane; Sobel, Mark E et al

in Journal of Cellular Biochemistry (1998), 71(1), 46-54

Homeodomain-containing proteins regulate, as transcription factors, the coordinated expression of genes involved in development, differentiation, and malignant transformation. We report here the molecular ... [more ▼]

Homeodomain-containing proteins regulate, as transcription factors, the coordinated expression of genes involved in development, differentiation, and malignant transformation. We report here the molecular cloning of a mutated HOXB7 transcript encoding a truncated homeodomain-containing protein in MCF7 cells. This is a new example of mutation affecting the coding region of a HOX gene. In addition, we detected two HOXB7 transcripts in several breast cell lines and demonstrated that both normal and mutated alleles were expressed at the RNA level in MCF7 cells as well as in a variety of breast tissues and lymphocytes, suggesting that a truncated HOXB7 protein might be expressed in vivo. Using transient co-transfection experiments, we demonstrated that both HOXB7 proteins can activate transcription from a consensus HOX binding sequence in breast cancer cells. Our results provide evidence that HOXB7 protein has transcription factor activity in vivo and that the two last amino acids do not contribute to this property. [less ▲]

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See detailEfficacy and Tolerability of Calcitonin in the Prevention and Treatment of Osteoporosis
Halkin, V; Reginster, Jean-Yves ULg

in BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals & Gene Therapy (1998), 10(4), 295-300

Calcitonin in general, and, more specifically, salmon calcitonin (salcatonin), has been known for 30 years to be a specific inhibitor of bone resorption. Studies have confirmed its efficacy in metabolic ... [more ▼]

Calcitonin in general, and, more specifically, salmon calcitonin (salcatonin), has been known for 30 years to be a specific inhibitor of bone resorption. Studies have confirmed its efficacy in metabolic bone diseases characterised by excessive bone resorption, such as osteoporosis. Most randomised studies in which salcatonin and oral calcium were administered for 1 to 5 years to recently postmenopausal women for the prevention of osteoporosis have shown that bone mineral density or bone content of the lumbar spine increased significantly, compared with a reduction among women receiving calcium only. Prospective studies have shown that salcatonin is effective in the treatment of established osteoporosis, reducing significantly the relative risk of new vertebral fractures. The benefits of salcatonin nasal spray therapy were observed in the majority of women studied, and it has been shown to be an effective alternative for osteoporotic women more than 5 years postmenopausal who refuse estrogens, or for whom estrogens are contraindicated. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect. The well-demonstrated effects of nasal calcitonin permit it to be considered a well tolerated and efficient approach for prevention and treatment of postmenopausal osteoporosis. [less ▲]

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See detailExpression and Modulation of Homeobox Genes from Cluster B in Endothelial Cells
Belotti, D.; Clausse, Nathalie; Flagiello, D. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1998), 78(10), 1291-9

Angiogenesis is a complex phenomenon likely to be under the strict control of a group of transcription factor(s). Homeobox (HOX)-containing proteins have been identified as regulators controlling the ... [more ▼]

Angiogenesis is a complex phenomenon likely to be under the strict control of a group of transcription factor(s). Homeobox (HOX)-containing proteins have been identified as regulators controlling the coordinated expression of genes involved in organ development and tissue differentiation. In this study, we have demonstrated that human umbilical vein endothelial cells (HUVEC) express 8 of the 10 HOX genes contained in cluster B. Treatment of HUVEC with tissue plasminogen activator (TPA), an agent known to induce morphologic changes in endothelial cells, or vascular endothelium growth factor (VEGF), a proliferative and angiogenesis inducer, results in a specific time-dependent modulation of the eight HOX genes identified. Interestingly, neither basic fibroblast growth factor, an endothelial proliferative agent, nor TNP-470, a fumagillin derivative with potent antiendothelial cell proliferation properties, affected expression of these HOX genes. Specific modulation of HOX genes by differentiating agents but not by proliferative or antiproliferative molecules suggests that they could be involved in the control of the genetic program that coordinates the construction of new blood vessels. [less ▲]

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See detailClinical Pattern of Corticosteroid Dependent Crohn's Disease
Franchimont, D. P.; Louis, Edouard ULg; Croes, F. et al

in European Journal of Gastroenterology & Hepatology (1998), 10(10), 821-5

OBJECTIVES: Corticosteroid dependency in Crohn's disease (CD) is characterized by the need for chronic use of corticosteroids to maintain clinical remission. Several definitions have been used. Depending ... [more ▼]

OBJECTIVES: Corticosteroid dependency in Crohn's disease (CD) is characterized by the need for chronic use of corticosteroids to maintain clinical remission. Several definitions have been used. Depending on the definition, 10-30% of the patients are considered as corticosteroid dependent. The aim of the study was to define a clinical pattern of corticosteroid dependent CD patients. PATIENTS AND METHODS: Epidemiological and clinical characteristics were retrospectively compared between 20 corticosteroid dependent CD patients and 248 non-corticosteroid dependent CD patients by using univariate and multivariate analyses. Corticosteroid dependency was defined either by two successive relapses during the 2 months after discontinuing glucocorticoids (n=5) or by two successive relapses at dose tapering, after successful treatment of a flare-up by using glucocorticoids (n=15). RESULTS: Corticosteroid dependent CD patients were younger at diagnosis (P < 0.001), and were characterized by a higher frequency of colonic location (P< 0.05), but lower frequency of ileal location (P < 0.01), and higher ano-perineal location (P < 0.05). They were also more frequently smokers (P< 0.05) and users of contraceptive pills (P< 0.01). The inflammatory type of the disease was increased (P < 0.01), while the fibrostenotic type was decreased (P < 0.001) in corticosteroid dependent CD patients. By multivariate analysis, a smoking habit (P < 0.01), a colonic location (P < 0.05), a non-fibrostenotic type (P< 0.05) and a younger age at diagnosis (P< 0.05) were shown to be independently associated with corticosteroid dependency. CONCLUSIONS: This study suggests a clinical pattern associated with corticosteroid dependency. Whether this clinical pattern is simply associated with the dependency, or whether a primary decrease of corticosensitivity produces this clinical pattern, is not known. Further prospective studies will have to determine whether the presence of these clinical characteristics is predictive of corticosteroid dependency and whether this prediction will be useful for the management of this condition. [less ▲]

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See detailL'image du mois. Embolisation utérine d'une tumeur trophoblastique persistante
Foidart, Jean-Michel ULg; Henroteaux, D.; Schaaps, Jean-Pierre ULg

in Revue Médicale de Liège (1998), 53(10), 585

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See detailA new theory for torsional stiffness of multi-span bundle overhead transmission lines.
Wang, Jianwei; Lilien, Jean-Louis ULg

in IEEE Transactions on Power Delivery (1998), 13(N°4), 1405-1411

A new theory for torsional stiffness of multi-span bundle overhead lines is presented.

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See detailStadsverkeer: problemen en olpossingen
Marchal, Jean ULg

in Publication du CAWET (Comité van de Academie voor Wetenschappen en Techniek) (1998)

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See detailPharma clinics. Comment je traite ... ou préviens une douleur par "patches"
Pierard, Gérald ULg

in Revue Médicale de Liège (1998), 53(10), 586-7

There exists two distinct types of patches aiming at increasing the pain threshold either systematically or locally. The first type of analgesic patch is a real transdermal delivery system releasing ... [more ▼]

There exists two distinct types of patches aiming at increasing the pain threshold either systematically or locally. The first type of analgesic patch is a real transdermal delivery system releasing fentanyl. Such potent opioid drug exerts a systemic effect. The other type of patch associates lidocain and prilocain to induce a local anesthesia of the skin without inducing a systemic effect. [less ▲]

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See detailRestriction of mobility in model liquid crystalline ionomers
Gohy, Jean-François; Jérôme, Robert ULg; Van den Bossche, Guy ULg et al

in Macromolecular Chemistry and Physics (1998), 199(10), 2205-2210

Model liquid crystalline ionomers have been analyzed by SAXS both in bulk and in toluene solution. These compounds are referred to as liquid crystalline halatosemitelechelic polystyrenes (LC HSTP's) and ... [more ▼]

Model liquid crystalline ionomers have been analyzed by SAXS both in bulk and in toluene solution. These compounds are referred to as liquid crystalline halatosemitelechelic polystyrenes (LC HSTP's) and consist of low molecular weight polystyrene chains end-capped at one end by a sulfonate group associated to a mesogenic counterion. The results are in agreement with a microphase separation between the polymer chain and the mesogenic counterion. The main characteristic feature of the SAXS profile for the bulk material is the so-called ionic peak, whose position obeys a general law which is in favor of a rod-like organization of the multiplets and which shows that the polymer chains are stretched in the very close vicinity of the mesogenic core, in agreement with the Eisenberg, Hird and Moore model for ionomers. The thickness of this region of restricted mobility has been estimated to 1 nm, which is the order of magnitude of the persistence length of polystyrene. This very local restriction in mobility persists in toluene solution, in contrast to what is observed for the ω-Li-sulfonato-polystyrene precursors. The results also agree with an isotropic distribution of the multiplets in toluene. [less ▲]

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See detailPrevalence and Molecular Typing of Attaching and Effacing Escherichia Coli among Calf Populations in Belgium
China, B.; Pirson, V.; Mainil, Jacques ULg

in Veterinary Microbiology (1998), 63(2-4), 249-259

Attaching and effacing Escherichia coli are involved in diarrhea in 2 to 8-week old calves. The virulence factors of these bacteria include: (i) the secretion of proteins (i.e. EspB) involved in ... [more ▼]

Attaching and effacing Escherichia coli are involved in diarrhea in 2 to 8-week old calves. The virulence factors of these bacteria include: (i) the secretion of proteins (i.e. EspB) involved in microvilli effacement, (ii) the production of the intimin, a 94 kDa outer membrane protein encoded by the eaeA gene and involved in the intimate attachment of bacteria to epithelial cell and (iii) the production of verotoxins: VT1 and/or VT2. We investigated the presence and the pathotype of these strains in several calf populations by colony hybridization or by genetic amplification. Using the colony hybridization method we showed first that only 5% of calves who died from diarrhea presented EaeA+ E. coli strains and secondly that 19% of healthy calves showed an asymptomatic carriage. However, using colony hybridization and genetic amplification, we identified EaeA+ strains in 91% of calves living in farms with recurrent diarrhea problems. In 66% of the calves, there was a correlation between the presence of AEEC and diarrhea. At the pathotype level, most of the EaeA+ isolates were negative for VT probes. In VT+ bacteria, the majority were VT1+. The number of VT positive bacteria was significantly higher in calves who died from diarrhea than in healthy or sick calves. This underlined the aggravating role of verotoxins in the disease. Moreover, only 25% of the bovine AEEC were positive with the EaeB probe. Surprisingly, the proportion of EaeB+ strains was significantly higher in healthy calves than in other populations. [less ▲]

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See detailConception des ouvrages hydrauliques
Rigo, Philippe ULg

in Ingénieur et Industrie, APPS éditions, n°5 (1998)

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See detailAge-related differences in random generation
Van der Linden, Martial ULg; Beerten, A.; Pesenti, M.

in Brain & Cognition (1998), 38(1), 1-16

This study investigated the effects of age on a random generation task. In Experiment 1, young and elderly subjects were asked to generate random strings of letters at 1-, 2-, and 4-s rates. The elderly ... [more ▼]

This study investigated the effects of age on a random generation task. In Experiment 1, young and elderly subjects were asked to generate random strings of letters at 1-, 2-, and 4-s rates. The elderly subjects produced more alphabetical stereotype responses than young subjects, even in the slowest rate condition. Furthermore, as faster rates were imposed, elderly subjects could no longer maintain the pace and missed responses. In Experiment 2, subjects were required to generate letters at the same time that they sorted cards into one, two, four, or eight categories. Age-related differences were observed on most of the measures of randomness (stereotypes, zero-order, and first-order measures). In addition, the number of errors increased with the number of sorting alternatives, especially for elderly subjects. These results suggest the existence of a reduction of the central executive resources, along with a reduced inhibition ability, in the elderly subjects. However, the contribution of a perceptual speed factor is also discussed. [less ▲]

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See detailThe burden of illness of hypopituitary adults with growth hormone deficiency.
Hakkaart-van Roijen, L.; Beckers, Albert ULg; Stevenaert, Achille ULg et al

in PharmacoEconomics (1998), 14(4), 395-403

Objective: The negative metabolic and psychosocial consequences of growth hormone deficiency (GHD) in adults are now well established. In the present study, an attempt was made to quantify the burden of ... [more ▼]

Objective: The negative metabolic and psychosocial consequences of growth hormone deficiency (GHD) in adults are now well established. In the present study, an attempt was made to quantify the burden of illness, in terms of lost productivity and increased medical consumption, associated with hypopituitarism and untreated GHD. Design and Setting: The study population consisted of 129 Belgian adults with untreated GHD associated with hypopituitarism after pituitary surgery. The Short-Form 36 Health Survey (SF-36) was used to assess health status, and the Health and Labour Questionnaire was used to measure production losses and labour performance. Data on medical consumption were also collected. Main Outcome Measures and Results: Hypopituitary patients reported a lower health status than that of the general population in all but two dimensions of the SF-36 (pain and physical functioning). Nearly 11% of the patients reported being incapacitated for paid employment due to health problems, compared with 4.8% of the general Belgian population. Patients in paid employment reported a mean of 19.8 days of sickness leave per year, which is twice that in the general population. The annual number of visits to general practitioners and specialists was also higher in the patients (9.6 and 6.5 visits, respectively, for the patients compared with corresponding figures of 2.1 and 1.5 for the general Belgian population). The average annual number of days spent in hospital was 3.5 for the patients compared with 2.3 in the general population. The annual healthcare costs and costs due to production losses calculated for hypopituitary patients who had received pituitary surgery amounted to 135 024 Belgian francs (BeF) or $US4340 (1995 values). This compares with the mean annual cost per person for the Belgian population as a whole of BeF68 569 or $US2204. Conclusions: Hypopituitary patients with untreated GHD therefore have a higher cost to society in terms of lost production and medical consumption than the average Belgian population. [less ▲]

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See detailIn Vitro Propagated Dendritic Cells from Patients with Human-Papilloma Virus-Associated Preneoplastic Lesions of the Uterine Cervix: Use of Flt3 Ligand
Hubert, Pascale ULg; Greimers, Roland ULg; Franzen-Detrooz, E. et al

in Cancer Immunology, Immunotherapy (1998), 47(2), 81-9

Dendritic cells (DC) are the most efficient antigen presenting cells. The clinical use of DC as vectors for antitumor and anti-infectious disease immunotherapy has been limited by their low level and ... [more ▼]

Dendritic cells (DC) are the most efficient antigen presenting cells. The clinical use of DC as vectors for antitumor and anti-infectious disease immunotherapy has been limited by their low level and accessibility in normal tissue. Substantial numbers of DC can be generated from peripheral blood cultured in the presence of interleukin-4 (IL-4) and granulocyte/macrophage-colony-stimulating factor (GM-CSF). We showed in this study that substantial numbers of DC can be obtained from the peripheral blood of patients with (pre)neoplastic lesions of the uterine cervix. The procedure required relatively small blood samples (10 ml) and the presence of 100 U/ml IL-4 and 800 U/ml GM-CSF in the culture medium. There was no significant difference in the morphology, yield, phenotype and function of generated DC between patients with cervical (pre)neoplastic lesions and healthy individuals. When the hematopoietic factor Flt3 ligand (Flt3L, 40 ng;ml) was added, there was an average increase in the DC population of 26% compared to cultures with GM-CSF and IL-4 alone. Approximately 1.2 x 10(6) cells with the characteristics of dendritic cells could be obtained when Flt3L was included in the medium. The addition of Flt3L did not modify the phenotypic profile of DC (HLA-DR+, CD1a+, CD4+, CD54+, CD80+, CD86+. CD40+, CD3- and CD14-). In addition, Flt3L generated functional DC capable of stimulating the proliferation of alloreactive T cells. These results suggest that Flt3L, in association with GM-CSF and IL-4, provides an advantageous tool for the large-scale generation of DC and that an immunotherapy based on the use of DC generated in vitro is possible in patients with (pre)neoplastic lesions of the uterine cervix. [less ▲]

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See detailLe cas clinique du mois. L'endocardite métastatique: observation clinique et revue de la littérature
Graas, M.P.; Evrard, P.; CREEMERS, Etienne ULg et al

in Revue Médicale de Liège (1998), 53(10), 588-91

The authors describe a case of metastatic endocarditis associated with a gastric carcinoma. The diagnosis was made early and the treatment by surgery and chemotherapy allowed a survival of 18 months ... [more ▼]

The authors describe a case of metastatic endocarditis associated with a gastric carcinoma. The diagnosis was made early and the treatment by surgery and chemotherapy allowed a survival of 18 months, which is unusually long. The differential diagnosis is discussed and includes nonbacterial thrombotic endocarditis, infectious endocarditis and primary tumors of the heart. [less ▲]

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See detailLe matérialisme transcendantal
Seba, Jean-Renaud ULg

in Cahiers marxistes (1998)

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See detailLa troponine, nouveau marqueur de l'infarctus du myocarde
Chapelle, Jean-Paul ULg

in Revue Médicale de Liège (1998), 53(10), 619-24

The troponin (Tn) complex consists of three protein subunits referred to as TnT, TnI and TnC. Myocardium contains TnI and TnT isoforms which are not present in skeletal muscles and which can be separated ... [more ▼]

The troponin (Tn) complex consists of three protein subunits referred to as TnT, TnI and TnC. Myocardium contains TnI and TnT isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) as quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in non cardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intensive physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage, and therefore may find new applications in the management of patients with unstable angina. [less ▲]

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See detail18fdg-Pet for the Assessment of Primary Head and Neck Tumors: Clinical, Computed Tomography, and Histopathological Correlation in 38 Patients
Paulus, Patrick; Sambon, A.; Vivegnis, Danielle et al

in Laryngoscope (1998), 108(10), 1578-83

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck ... [more ▼]

OBJECTIVES: To evaluate the clinical usefulness of FDG-PET (fluoro-2-deoxy-glucose-positron emission tomography) in the detection of lymph node involvement and recurrences in patients with head and neck cancer. STUDY DESIGN: Retrospective review of 38 patients with biopsy-proven head and neck cancers who underwent clinical, computed tomography (CT), and FDG-PET examinations. Twenty-five patients were studied prior to therapy and 13 patients were evaluated for disease recurrence. METHODS: All patients were operated and clinical data, CT, and FDG-PET results were correlated with histopathological findings. RESULTS: All primary tumors in 25 patients were detected, with the exception of one small superficial localization of the epiglottis. Histopathological examination showed lymph node involvement in 10 patients; PET detected lymph node involvement in five. FDG-PET found one case of nodal disease not identified by clinical and CT examination. With so few cases, this could be anecdotal. Five false-negative results (microscopic lymph node involvement) and two false positives were noted. Twelve of 13 patients with recurrent disease were correctly identified with FDG-PET. FDG-PET was the only imaging technique to identify local recurrence in two patients and lymph node involvement in two others. One false-positive result occurred in a patient with a foreign body granuloma. CONCLUSIONS: FDG-PET is a useful diagnostic modality for the detection of recurrent tumors and, in selected cases, precise lymph node involvement. The best way to further investigate the utility of clinical FDG-PET is in the follow-up of treated patients. [less ▲]

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See detailFoam-like evolution in polycrystalline systems following successive 'melt and growth' cycles
Vandewalle, Nicolas ULg; Delisse, B.; Ausloos, Marcel ULg et al

in Philosophical Magazine B-Physics of condensed matter statistical mechanics electronic optical and magnetic properties (1998), 78(4), 397-408

A stochastic model of multigrain growth which allows for successive melting-growth cycles is investigated on a square lattice. Two fundamental constraints are introduced: (i) the melted mass amplitude and ... [more ▼]

A stochastic model of multigrain growth which allows for successive melting-growth cycles is investigated on a square lattice. Two fundamental constraints are introduced: (i) the melted mass amplitude and (ii) the number of cycles guide the process. The evolution of the microstructure is found to be quite similar to foam systems, i.e. topological rearrangements are observed together with the increase of the-mean grain area. A drastic crossover between two types of growth regimes is found as a function of the amplitude of the melting-growth cycles. This allows one to envisage the existence of optimal conditions for polycrystal processing. [less ▲]

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See detailAn unusual pituitary pathology
Petrossians, Patrick ULg; Delvenne, Philippe ULg; Flandroy, P. et al

in Journal of Clinical Endocrinology and Metabolism (1998), 83(10), 3454-3458

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See detailAcromégalie : Consultation
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 49

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See detailAcromegalie : Consult
Beckers, Albert ULg; Stevenaert, Achille ULg

in Medical News (1998), 49

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See detailInfluence of end group and molecular weight on polybutadiene fingerprint secondary ion mass spectra
Vanden Eynde, X.; Bertrand, P.; Dubois, Philippe ULg et al

in Macromolecules (1998), 31(19), 6409-6416

Polybutadiene samples of different molecular weight have been synthesized by anionic polymerization as initiated by sec-butyllithium with low polydispersity and a major content of 1,2-vinyl units. They ... [more ▼]

Polybutadiene samples of different molecular weight have been synthesized by anionic polymerization as initiated by sec-butyllithium with low polydispersity and a major content of 1,2-vinyl units. They have been analyzed by time-of-flight secondary ion mass spectrometry (ToF-SIMS) in order to investigate the sensitivity of this method toward the sec-butyl end group and toward the molecular weight. The SIMS spectra show the characteristic fragment of the end group, C4H9+ at m/z = 57, whose the peak intensity is strongly dependent on the polymer molecular weight, as is the case for almost all the fragment intensities. A model consistent with the peak intensity variations is used to give some new insights into the fragmentation mechanism at the end groups and within the main chain. Moreover, the analysis of the end group fragment allows Mn to be readily determined up to Mn = 4 × 104 from, for example, the Y(53)/Y(57) intensity ratio where Y(53) is the intensity of the deprotonated repeat unit ([M − H]+). Other Mn calibration methods have also been used and are discussed in terms of their accuracy and physical meaning. [less ▲]

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See detailDecreased Protein Levels of the C-Cbl Protooncogene in Murine Aids
Trebak, Mohamed; Lambert, Charles A; Rahmouni, Souad ULg et al

in Cellular Immunology (1998), 188(2), 151-7

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do ... [more ▼]

Murine acquired immunodeficiency syndrome (MAIDS) can be viewed as a lymphoproliferative disease which involves B cells as well as T cells from spleen and lymph nodes while thymus and Peyer's patches do not participate in the process. The 120-kDa protooncogene product c-Cbl was initially cloned from the murine Cas NS-1 B cell lymphoma. It is a main target of immunoreceptor (TCR and BCR)-mediated protein tyrosine kinase activity. Moreover, recent data suggest that c-Cbl might play a crucial role in the regulation of cell proliferation through regulation of GTP-binding proteins. Therefore, the involvement of c-Cbl was evaluated in the lymphoproliferative disease induced by the MAIDS virus. The expression of the c-Cbl protein was dramatically reduced in the lymph node of infected mice while it remained normal in the thymus. In contrast, the expression of actin, TCR-zeta chain, ZAP-70, and p59(fyn) remained similar in controls and infected mice. Identical results were obtained with sorted B cells and T cells. Surprisingly, a B cell lymphoma line derived from late stage MAIDS mice displayed a normal level of c-Cbl. [less ▲]

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See detailSimultaneous Determination of Methylphenobarbital Enantiomers and Phenobarbital in Human Plasma by on-Line Coupling of an Achiral Precolumn to a Chiral Liquid Chromatographic Column
Ceccato, Attilio ULg; Boulanger, Bruno ULg; Chiap, Patrice ULg et al

in Journal of Chromatography. A (1998), 819(1-2), 143-53

A fully automated liquid chromatographic (LC) method for the simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma has been developed. The method is based on the ... [more ▼]

A fully automated liquid chromatographic (LC) method for the simultaneous determination of methylphenobarbital enantiomers and phenobarbital in human plasma has been developed. The method is based on the use of a precolumn packed with an internal-surface reversed-phase packing material (LiChrospher ADS) for sample clean-up coupled to LC analysis on a cellulose tris(4-methylbenzoate) based chiral stationary phase (Chiralcel OJ-R). A 100-microliter plasma sample was injected directly on the precolumn packed with LiChrospher RP-18 ADS using a mixture of pH 5.0 phosphate buffer-methanol (97:3, v/v) as washing liquid. The analytes were then eluted in the back-flush mode with the LC mobile phase. The enantiomeric separation of methylphenobarbital was achieved on Chiralcel OJ-R). The retention times were modelled using a D-optimal design with ten experimental points in order to optimise the LC mobile phase for the separation of phenobarbital from the enantiomers of mephobarbital. The factors selected were the acetonitrile content, the pH and the sodium perchlorate concentration in the mobile phase. A Derringer's desirability function was used to find an optimal and robust solution within the experimental domain. The mobile phase selected consisted of a mixture of pH 7.0 phosphate buffer-acetonitrile (60:40, v/v). The elution profiles of phenobarbital, methylphenobarbital and blank plasma samples on the precolumn and the time needed for analyte transfer from the precolumn to the analytical column were then determined. Finally, the method developed was validated. [less ▲]

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See detailEffects of Brain Testosterone Implants on Appetitive and Consummatory Components of Male Sexual Behavior in Japanese Quail
Riters, L. V.; Absil, Philippe ULg; Balthazart, Jacques ULg

in Brain Research Bulletin (1998), 47(1), 69-79

Aromatization of testosterone (T) into an estrogen is necessary for the activation of consummatory and appetitive sexual behavior in male Japanese quail. T action within the medial preoptic nucleus (POM ... [more ▼]

Aromatization of testosterone (T) into an estrogen is necessary for the activation of consummatory and appetitive sexual behavior in male Japanese quail. T action within the medial preoptic nucleus (POM) is necessary and sufficient to activate consummatory behavior, and some evidence suggests that POM might be involved in the control of appetitive behavior, but other brain regions, such as the bed nucleus of the stria terminalis (BST), an area that contains a dense population of aromatase-immunoreactive neurons, are also likely to be involved. This study was performed to assess the effects of stereotaxic T implants targeting either the POM or the BST on the activation of both components of sexual behavior in castrated male quail. Appetitive sexual behavior was measured by an acquired social proximity response in which a male will approach a window providing visual access to a female after the window has been repeatedly paired with physical access to a female and the possibility to freely interact with her. Rhythmic cloacal sphincter movements that are produced by the male when given visual access to a female were used as another measure of appetitive sexual behavior that does not appear to depend on sexual learning. The experiments confirmed that copulation is necessary for males to develop the social proximity response that is used to measure the appetitive sexual behavior. T implants in the POM activated both components of sexual behavior, suggesting that these components cannot be completely dissociated. In contrast, T implants located within the BST did not affect either component, but because implants in the BST did not activate copulatory behavior, these results do not preclude a role for BST in the expression of a previously acquired appetitive sexual behavior. [less ▲]

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See detailSimultaneous Determination of Pirlindole Enantiomers and Dehydropirlindole by Chiral Liquid Chromatography
Ceccato, Attilio ULg; Hubert, Philippe ULg; De Tullio, Pascal ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1998), 17(6-7), 1071-9

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved ... [more ▼]

Liquid chromatography was employed for the determination of pirlindole enantiomers and its oxidation product dehydropirlindole (DHP). The direct separation of pirlindole enantiomers and DHP was achieved on a cellulose tris-(3,5-dimethylphenylcarbamate) chiral stationary phase (Chiralcel OD-R). Acetonitrile was used as the organic modifier and sodium perchlorate was used as an ionic additive in the mobile phase. The influence of acetonitrile and sodium perchlorate concentrations on enantioselectivity and achiral selectivity towards DHP was investigated in order to find suitable conditions for the determination of low amounts of each analyte. The mobile phase selected consisted of a mixture of acetonitrile and phosphate buffer (pH 5.0) containing sodium perchlorate (0.05 M) (35:65, v/v) and the UV detector was set at 220 nm. The method developed was validated and was found to be linear in the 0.1-5 microg ml(-1) range (r2 = 0.999 for the three compounds). Repeatability and the intermediate precision for the three analytes at a concentration of 0.1 microg ml(-1) were about 3 and 4%, respectively. This concentration corresponds to the quantification of 0.1% for the minor enantiomer. Actual determinations of enantiomeric purity for single enantiomers of pirlindole were performed. [less ▲]

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See detailHubble Space Telescope imaging of Jupiter's UV aurora during the Galileo orbiter mission
Clarke, John T; Ben Jaffel, Lotfi; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (1998), 103

Hubble Space Telescope (HST) Wide-Field Planetary Camera 2 (WFPC 2) images of Jupiter's aurora have been obtained close in time with Galileo ultraviolet spectrometer (UVS) spectra and in situ particles ... [more ▼]

Hubble Space Telescope (HST) Wide-Field Planetary Camera 2 (WFPC 2) images of Jupiter's aurora have been obtained close in time with Galileo ultraviolet spectrometer (UVS) spectra and in situ particles, fields, and plasma wave measurements between June 1996 and July 1997, overlapping Galileo orbits G1, G2, G7, G8, and C9. This paper presents HST images of Jupiter's aurora as a first step toward a comparative analysis of the auroral images with the in situ Galileo data. The WFPC 2 images appear similar to earlier auroral images, with the main ovals at similar locations to those observed over the preceding 2 years, and rapidly variable emissions poleward of the main ovals. Further examples have been observed of the equatorward surge of the auroral oval over 140-180° longitude as this region moves from local morning to afternoon. Comparison of the WFPC 2 reference auroral ovals north and south with the VIP4 planetary magnetic field model suggests that the main ovals map along magnetic field lines exceeding 15R[SUB]J[/SUB], and that the Io footprint locations have lead angles of 0-10° from the instantaneous magnetic projection. There was an apparent dawn auroral storm on June 23, 1996, and projections of the three dawn storms imaged with HST to date demonstrate that these appear consistently along the WFPC 2 reference oval. Auroral emissions have been consistently observed from Io's magnetic footprints on Jupiter. Possible systematic variations in brightness are explored, within factor of 6 variations in brightness with time. Images are also presented marked with expected locations of any auroral footprints associated with the satellites Europa and Ganymede, with localized emissions observed at some times but not at other times. [less ▲]

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See detailPhysiologic Response to Dobutamine Infusion During Cardiac Stress Testing of Dogs
Mc Entee, Kathleen ULg; Amory, Hélène ULg; Clercx, Cécile ULg et al

in American Journal of Veterinary Research (1998), 59(9), 1160-5

OBJECTIVE: To evaluate response of various cardiovascular variables after administration of incremental doses of dobutamine in healthy conscious dogs, using standardized dobutamine stress echocardiography ... [more ▼]

OBJECTIVE: To evaluate response of various cardiovascular variables after administration of incremental doses of dobutamine in healthy conscious dogs, using standardized dobutamine stress echocardiography (DSE). ANIMALS: 8 healthy dogs. PROCEDURE: A DSE was performed twice on each dog within 24 hours. Dobutamine was infused at a rate of 12.5 to 42.5 microg/kg/min, using incremental increases of 10 microg/kg/min. Doppler sphygmomanometry, electrocardiography, and echocardiography were performed. Left ventricular size, global ventricular performance, and left ventricular systolic myocardial function were measured by means of echocardiography. RESULTS: At the highest dosage, dobutamine induced an increase of 20+/-3% and 109+/-12% in systolic blood pressure and cardiac index, respectively. The latter was associated with a significant increase in heart rate and stroke index. Fractional shortening of the left ventricle, fractional thickening of the left ventricular free wall and interventricular septum, ejection fraction, and mean velocity of fiber shortening had a progressive and significant increase during dobutamine infusion. Preejection period and left ventricular ejection time had a progressive and significative decrease during the stress test. CONCLUSIONS: The technique used was feasable, safe, and repeatable in healthy conscious dogs. Control values were determined. CLINICAL RELEVANCE: Data for these healthy dogs might be useful for comparison with results obtained from dogs with known or suspected cardiovascular disease. [less ▲]

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See detailTransglutaminase-Mediated Oligomerization of Galectin-3 Modulates Human Melanoma Cell Interactions with Laminin
van den Brule, F. A.; Liu, F. T.; Castronovo, Vincenzo ULg

in Cell Adhesion and Communication (1998), 5(6), 425-35

Tumor cell adhesion and migration to laminin are important events during invasion and metastatic spread. Galectin-3, a multifunctional member of the galectin family, binds specifically the poly-N ... [more ▼]

Tumor cell adhesion and migration to laminin are important events during invasion and metastatic spread. Galectin-3, a multifunctional member of the galectin family, binds specifically the poly-N-acetyllactosamine residues of laminin and has been implicated in tumor invasion and metastasis. Galectin-3 is multimerized by transglutaminase, an enzyme that catalyzes cross-linking between glutamine and other aminoacid residues. In this study, we examined the consequences of transglutaminase-mediated galectin-3 oligomerization on the interactions between cancer cells and laminin. We first demonstrated that human galectin-3 is cross-linked by guinea pig liver transglutaminase, forms oligomers, and incorporates the marker 5-(biotinamido) pentylamine. Expression of transglutaminase activity in the A375 and A2058 human melanoma cell extracts was revealed by its ability to induce galectin-3 oligomerization and 5-(biotinamido) pentylamine incorporation. Transglutaminase-treated galectin-3 did not affect adhesion or migration of the melanoma cells to laminin but consistently induced a significant increase of the percentage of cell spreading compared to the control (23.5 +/- 2.3%, vs. 10.6 +/- 1.9% at 180 min, p < 0.05), or to untreated galectin-3 or transglutaminase alone. Our study is the first demonstration that human galectin-3 is oligomerized by transglutaminase with, as a consequence, a specific effect of melanoma cell spreading on laminin. This phenomenon could be of significance in the modulation of cancer cell interactions with laminin during tumor invasion and metastasis. [less ▲]

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See detailZoonoses cutanées transmises par les chiens et les chats
Pierard, Gérald ULg; Pierard-Franchimont, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (1998), 53(9), 532-536

Pets like dogs and cats are responsible for a series of zoonotic disorders. Some of these diseases are inflicted by bites, scratches or licking. Others result from a close contact with fur, or are ... [more ▼]

Pets like dogs and cats are responsible for a series of zoonotic disorders. Some of these diseases are inflicted by bites, scratches or licking. Others result from a close contact with fur, or are transmitted by ectoparasites or by the contaminated environment. Some systemic infectious and parasitic diseases are transmitted from animals to humans and vice versa. Such situation may lead to endemic problems in some communities. [less ▲]

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See detailSensus communis
Spinoy, Erik ULg

in De Vlaamse Gids (1998), 82(4), 13-15

This article is a critical reflection on the literary views held by the Dutch postwar poet Rutger Kopland.

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See detailEsquisse de bilan
Duchesne, Jean-Patrick ULg

in Nouvelles du Patrimoine (Les) (1998), 78

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See detailInfections à Cytomegalovirus (CMV) chez les transplantés d’organes
Detry, Olivier ULg

in Virologics : la Virologie du Sida au Zona (1998)

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See detailLa chirurgie du cancer oesophagien à Liège: III. Evaluation clinique et radiographique de la qualité de vie à long terme après oesophagectomie
Kolh, Philippe ULg; Boverie, Jacques ULg; Honore, Pierre ULg et al

in Revue Médicale de Liège (1998), 53(9), 564-70

OBJECTIVE: Functional evaluation of digestive transplants after oesophagectomy for cancer. MATERIAL AND METHODS: We evaluated alimentary comfort and quality of life and performed a videofluoroscopy ... [more ▼]

OBJECTIVE: Functional evaluation of digestive transplants after oesophagectomy for cancer. MATERIAL AND METHODS: We evaluated alimentary comfort and quality of life and performed a videofluoroscopy (radiocinema) in 34 patients who were alive and disease-free one year or more after oesophagectomy for malignancy. There were 22 males and 12 females; mean age was 64 years. Twenty-three patients had a gastric pull-up and 11 a colonic graft. Mean follow-up was 36 months (range: 12-100 months). Possible correlations between clinical symptoms and radiographic observations were studied with Fisher's exact test. RESULTS: Most-cited symptoms were gurgling in 16 patients, early fullness during eating in 15, diarrhea in 14, postprandial sweating in 9, pyrosis in 8, nocturnal cough in 7, and dysphagia in 5. Most patients considered the side effects of the operation as mild to moderate and mean rating of alimentary comfort was 7.6/10. Twenty-five patients qualified their quality of life as good, 8 as satisfactory, and 1 as poor. Twenty-nine patients led active lives. Videofluoroscopic evaluation showed that colonic grafts emptied mainly by gravity, while active contractions were observed in the antrum of gastric transplants. There was a significant correlation between alimentary symptoms and radiographic distension of the transplant. Oro-pharyngeal abnormalities, site of proximal anastomosis, nature, motility, or active versus passive emptying of the transplant did not correlate with clinical complaints. CONCLUSIONS: In most patients quality of life and alimentary comfort are good after oesophagectomy and gastric or colonic interposition. Radiocinema is an adequate method to evaluate the dynamic of the transplant and shows a better emptying of gastric grafts, compared to colonic grafts, particularly when the proximal portion of the oesophagus triggers the progression. [less ▲]

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See detailAttachment but Not Penetration of Bovine Herpesvirus 1 Is Necessary to Induce Apoptosis in Target Cells
Hanon, Emmanuel; Meyer, Gilles; Vanderplasschen, Alain ULg et al

in Journal of Virology (1998), 72(9), 7638-41

Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although ... [more ▼]

Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in bovine peripheral blood mononuclear cells and B-lymphoma cells. Using a BHV-1 glycoprotein H null mutant, we have demonstrated that although penetration of BHV-1 is not required, attachment of BHV-1 viral particles is essential for the induction of apoptosis. [less ▲]

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See detailLa transplantation rénale: aspect chirurgical
Detry, Olivier ULg; Bonnet, Pierre ULg; Meurisse, Michel ULg

in Horizon (1998), 18(70), 48-49

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See detailThe Relationship between Spermine Content of Human Milk During the First Postnatal Month and Allergy in Children
Peulen, Olivier ULg; Dewé, Walthère ULg; Dandrifosse, Guy ULg et al

in Public Health Nutrition (1998), 1(3), 181-4

DESIGN: Qualitative case study and mathematical model. SETTING: Belgium. OBJECTIVES: To evaluate the correlation between the polyamine mean concentration of the milk drunk during the first postnatal month ... [more ▼]

DESIGN: Qualitative case study and mathematical model. SETTING: Belgium. OBJECTIVES: To evaluate the correlation between the polyamine mean concentration of the milk drunk during the first postnatal month and the appearance of allergy in children who drank this milk. RESULTS: A model that describes the dependence of the allergy appearance with the spermine mean concentration of milk drunk during the first postnatal month was established. CONCLUSIONS: This model shows that 5.02 nmol ml(-1) of spermine is a critical value to prevent the appearance of allergy. [less ▲]

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See detailL'Obésité chez l'enfant.
Guillaume, Michèle ULg; Burniat, W.

in ONE (1998)

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See detailBIG LUCKY CARTER - Richard HITE - LEROY MARTIN
Sacré, Robert ULg

in Soul Bag (1998), (152), 25

Photo : Richard HITE, Leroy MARTIN et Big Lucky CARTER ( Memphis, TN, avril 1985)

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See detailL'art public
Duchesne, Jean-Patrick ULg

in Nouvelles du Patrimoine (Les) (1998), 78

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See detailÉVALUATION MULTICRITÈRE D’ENTREPRISES PUBLIQUES DU RAIL
Mbangala, Mapapa ULg; Colson, Gérard ULg

in Finéco (1998), 8

Les performances de dix entreprises publiques africaines du rail sont comparées entre elles au moyen des méthodes multicritères ELECTRE I, PROMETHEE II et JUDGES. Les 25 critères de premier niveau retenus ... [more ▼]

Les performances de dix entreprises publiques africaines du rail sont comparées entre elles au moyen des méthodes multicritères ELECTRE I, PROMETHEE II et JUDGES. Les 25 critères de premier niveau retenus sont regroupés d’abord en 8 familles capturant chacune un objectif de deuxième niveau. L’efficacité du service est mesurée par une fonction d’évaluation technicoéconomique regroupant les 4 premières familles. Son efficience est mesurée par une fonction d’évaluation où interviennent les 4 autres familles constituées de ratios financiers classiques susceptibles de capter l’équilibre de gestion et l’origine des ressources financières. Les auteurs effectuent des analyses longitudinales et transversales des données en comparant les résultats obtenus par ELECTRE et PROMETHEE. Le logiciel JUDGES fait apparaître successivement l’arbre des corrélations observées entre les 8 familles de critères, et les distributions de rangs des entreprises selon 8 familles. D’un point de vue méthodologique, ce travail propose une variante d’ELECTRE I et vérifie la pertinence des méthodes multicritères en matière de classement de performance des entreprises publiques. [less ▲]

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See detailOptimization of the width of a thin plate in a transverse flux induction furnace
Hedia, Hakim; Henrotte, François; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1998), 34(5), 3118-3121

This paper presents the analysis of a transverse flux induction furnace. The originality of the analysis presented in this paper is to use successively three different formulations in order to solve the ... [more ▼]

This paper presents the analysis of a transverse flux induction furnace. The originality of the analysis presented in this paper is to use successively three different formulations in order to solve the magneto-thermal coupled problem. The Whitney elements (node based, edge based, facet based and volume based elements) are shown to be a convenient mean to perform naturally that coupling and to fulfill convergence conditions for the iterative solver. [less ▲]

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See detailSupramolecular organization of model liquid crystalline ionomers
Gohy, Jean-François; Jérôme, Robert ULg; Van den Bossche, Guy ULg et al

in Macromolecular Chemistry and Physics (1998), 199(9), 1791-1799

A mesogenic cation was associated with low molecular weight carboxylato- and sulfonato(se-mi)telechelic polymers. These compounds were prepared by ion-exchange of the quaternary ammonium group attached to ... [more ▼]

A mesogenic cation was associated with low molecular weight carboxylato- and sulfonato(se-mi)telechelic polymers. These compounds were prepared by ion-exchange of the quaternary ammonium group attached to the mesogen for the metal counterion of the halato(semi)telechelic polymer. The accordingly formed liquid crystalline halato(semi)telechelic polymers (LC H(S)TP's) were analyzed by differential scanning calorimetry (DSC), polarized-light optical microscopy (POM), and small angle X-ray scattering (SAXS). On the basis of these experimental results, a model for the supramolecular organization of the LC H(S)TP's is proposed. The final morphology results from the interplay of two competitive effects: the dipolar interaction of the ion-pairs known for multiplet formation and the propensity of the mesogenic moiety to form mesophases. The outcome of this competition depends on the mobility of the mesogenic counterion, i.e., on the strength of the dipolar interactions, the mobility of the polymer backbone and the mesogen/poly-mer ratio which is controlled by the molecular weight of the polymer. [less ▲]

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See detailCoupling of Local and Global Quantities in Various Finite Element Formulations and its Application to Electrostatics, Magnetostatics and Magnetodynamics
Dular, Patrick ULg; Legros, Willy ULg; Nicolet, André

in IEEE Transactions on Magnetics (1998), 34(5), 3078-3081

A method for defining global quantities related to fluxes and circulations is proposed in the frame of the finite element method. The definition is in perfect accordance with the discretized weak ... [more ▼]

A method for defining global quantities related to fluxes and circulations is proposed in the frame of the finite element method. The definition is in perfect accordance with the discretized weak formulations of the problems. It therefore enables a natural coupling between local and global quantities in various formulations, while keeping a symmetrical matrix for the system, and then is open to the coupling of physical problems. Applications are given for electrostatics, magnetostatics and magnetodynamics [less ▲]

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See detailBig Lucky CARTER photo
Sacré, Robert ULg

in Soul Bag (1998), (152),

Big Lucky Carter , Memphis -Photo

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See detailStratégies vaccinales pour le médecin généraliste. I. A propos d'une recherche-action
Limme, C.; Bouüaert, Corine ULg; Miermans, Marie-Christine ULg et al

in Revue Médicale de Liège (1998), 53(9), 541-52

The methodology of "Research-Action" requires that the general practitioner acts as the observant as well the actor. This methodology is a good way to identify the several problems and to find their ... [more ▼]

The methodology of "Research-Action" requires that the general practitioner acts as the observant as well the actor. This methodology is a good way to identify the several problems and to find their solution. In this option, the G.P. is the main person to plan, to manage and to follow the vaccination program for the "six and more years old children". [less ▲]

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See detailFluorine-18 deoxyglucose positron emission tomography for the detection of bone metastases in patients with non-small cell lung cancer
Bury, Thierry ULg; BARRETO, A.; Daenen, Frédéric ULg et al

in European Journal of Nuclear Medicine (1998), 9

Despite advances in morphological imaging, some patients with lung cancer are found to have non resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone ... [more ▼]

Despite advances in morphological imaging, some patients with lung cancer are found to have non resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone involvement is usually assessed using bone scintigraphy, which has a high sensitivity but a poor specificity. We have attempted to evaluate the utility of the fluorine-18 deoxyglucose positron emission tomography (FDG PET) for the detection of bone metastasis. One hundred and ten consecutive patients with histological diagnosis of non-small cell lung cancer (NSCLC) who underwent both FDG PET and bone scintigraphy were selected for this review. In this group, there were 43 patients with metastatic disease (stage IV). Among these. 21 (19% of total group) had one or several bone metastases confirmed by biopsy (n = 8) or radiographic techniques (n = 13). Radionuclide bone scanning correctly identified 54 out of 89 cases without osseous involvement and 19 out of 21 osseous involvements. On the other hand, FDG PET correctly identified the absence of osseous involvement in 87 out of 89 patients and the presence of bone metastasis in 19 out of 21 patients. Thus using PET there were two false-negative and two false-positive cases. PET and bone scanning had, respectively, an accuracy of 96% and 66% in the evaluation of osseous involvement in patients with NSCLC. In conclusion, our data suggest that whole-body FDG PET may be useful in detecting bone metastases in patients with known NSCLC. [less ▲]

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See detailNouveau code wallon de l'urbanisme : évolutions récentes
Delnoy, Michel ULg

in Immobilier (1998), 15

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See detailNew ligands for the living high-molecular-weight anionic (co)polymerization of acrylates in toluene at 0°C.1,2 3. Ligation of sec-butyllithium by lithium silanolates
Zundel, Thomas; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1998), 31(17), 5577-5581

sec-Butyllithium combined with a new family of ligands, (i.e., lithium silanolates), has been used to initiate the ligated anionic polymerization of n-butyl acrylate (BuA) in toluene at low temperature ... [more ▼]

sec-Butyllithium combined with a new family of ligands, (i.e., lithium silanolates), has been used to initiate the ligated anionic polymerization of n-butyl acrylate (BuA) in toluene at low temperature. Compared to other μ-ligands, sBuMe2SiOLi is a more efficient stabilizer of the active centers. Thus, under selectively chosen reaction conditions, the polymerization proceeds quantitatively at −40 °C, producing a high-molecular-weight polymer with narrow-molecular-weight distribution (Mw/Mn < 1.2). When the copolymerization of BuA is initiated by a living {PMMALi, 5·sBuDLi} in toluene at −78 °C, the experimental data agree with a well-controlled block copolymerization reaction, since the final molecular-weight distribution is very narrow (Mw/Mn ≤ 1.1) and the polymerization efficiency very high. [less ▲]

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See detailDiffusive radical entry as the rate-determining step in amphiphilic block polyelectrolyte mediated emulsion polymerization
Leemans, Luc; Jérôme, Robert ULg; Teyssié, Philippe

in Macromolecules (1998), 31(17), 5565-5571

The amphiphilic water soluble block polyelectrolytes PMMA-b-SPGMA and PMMA-b-QPDMAEMA are efficient surfactants for the radical emulsion polymerization. Negatively charged, neutral, and positively charged ... [more ▼]

The amphiphilic water soluble block polyelectrolytes PMMA-b-SPGMA and PMMA-b-QPDMAEMA are efficient surfactants for the radical emulsion polymerization. Negatively charged, neutral, and positively charged entering radicals were used in combination with polyanionically and polycationically tailored PMMA latex particles. It was shown that the rate of polymerization was very high for systems wherein the entering radical species had an electrical charge sign identical with that of the polyelectrolyte corona around the latex particle. PMMA-b-SPGMA turned out to be 4 times as efficient as compared to SDS emulsified MMA polymerization at 0.6 wt %. Systems wherein polyelectrolyte block and entering radical were of opposite sign displayed strongly reduced polymerization rates. When the polyelectrolyte barrier became thick enough, as in the case of a Mn = 26 000 PMMA-b-QPDMAEMA, no more polymerization was observed. The observed polymerization rate effects are discussed in terms of repulsion of equal charge radicals, leading to enhanced mobility and counterion mobility restriction of the radicals of opposite sign to the polyelectrolyte block. In the latter case, this slowed counterion diffusion of radicals of opposite sign leads to premature aqueous phase termination of free radicals and consequently low flux of entering radicals with low rates of polymerization. The experimental results obtained are consistent with the theoretically predicted case, where the “control by aqueous phase growth” theory for the entry of free radicals in latex particles is invalid. [less ▲]

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See detailPartial Cloning and Distribution of Estrogen Receptor Beta in the Avian Brain
Lakaye, Bernard ULg; Foidart, Agnès ULg; Grisar, Thierry ULg et al

in Neuroreport (1998), 9(12), 2743-8

A partial estrogen receptor beta (ER-beta) cDNA was isolated from testicular quail RNA by RT-PCR with degenerate primers specific to the rat ER-beta sequence. A high expression of ER-beta was demonstrated ... [more ▼]

A partial estrogen receptor beta (ER-beta) cDNA was isolated from testicular quail RNA by RT-PCR with degenerate primers specific to the rat ER-beta sequence. A high expression of ER-beta was demonstrated by RT-PCR in the telencephalon, diencephalon, pituitary, testis and kidneys of male quail but little or no expression was detected in the cerebellum, pectoral muscle and adrenal gland. In situ hybridization with a 35S-labelled oligoprobe in sections through the preoptic area-rostral hypothalamus identified high expression in the medial preoptic nucleus, bed nucleus striae terminalis and nucleus taeniae. These data demonstrate the presence of an ER-beta in brain areas implicated in the control of reproduction in a non-mammalian species. [less ▲]

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See detailAppetitive and consummatory male sexual behavior in Japanese quail are differentially regulated by subregions of the preoptic medial nucleus
Balthazart, Jacques ULg; Absil, Philippe ULg; Gérard, Marie-Paule ULg et al

in Journal of Neuroscience (1998), 18(16), 6512-6527

Central testosterone aromatization is required for the activation of both appetitive (ASB) and consummatory (CSB) male sexual behavior in Japanese quail. There are two major clusters of aromatase ... [more ▼]

Central testosterone aromatization is required for the activation of both appetitive (ASB) and consummatory (CSB) male sexual behavior in Japanese quail. There are two major clusters of aromatase immunoreactive (ARO-ir) cells in the rostral forebrain; these outline the nucleus preopticus medialis (POM) and the nucleus striae terminalis (BST). We investigated the role of these nuclei in the regulation of ASB and CSB. Appetitive male sexual behavior was measured with the use of a learned social proximity procedure that quantified the time spent by a male in front of a window with a view of a female who was subsequently released into the cage, providing an opportunity for CSB. Males first acquired the response and then received bilateral electrolytic lesions aimed at the POM or BST, followed by retesting for ASB and CSB. Brain sections were stained for ARO-ir, and lesions to the two ARO-ir cell groups were quantitatively characterized. Lesions damaging the POM completely abolished CSB and also significantly decreased ASB. Lesions of the rostral BST had no effect on ASB, but moderately decreased CSB. Detailed anatomical analysis revealed that lesions of a subdivision of the POM just rostral to the anterior commissure specifically impair CSB, whereas lesions that are more rostral to this subdivision induce a severe deficit in ASB. These data indicate that different subregions of the POM regulate ASB and CSB in a somewhat independent manner, whereas the BST is only important in the regulation of CSB. [less ▲]

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See detailLe cas clinique du mois. Nodules pulmonaires multiples. L'hémangio-endotheliome epithelioide
Vandenheede, Michel; Salem, T.; Sayago, I. et al

in Revue Médicale de Liège (1998), 53(8), 454-8

The epithelioid hemangioendothelioma of the lung is generally detected incidentally by a routine chest radiograph, usually in young asymptomatic woman. This tumor pursues a clinical course intermediate ... [more ▼]

The epithelioid hemangioendothelioma of the lung is generally detected incidentally by a routine chest radiograph, usually in young asymptomatic woman. This tumor pursues a clinical course intermediate between that of hemangioma and angiosarcoma. Survival over 20 years have already been described in the literature. We report the case of a pulmonary epithelioid hemangioendothelioma diagnosed 16 years ago, with hepatic metastases and a radiologic follow-up that highlights the slow evolution of the pulmonary and hepatic lesions. [less ▲]

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See detailPharma clinics. Comment je préviens et je traite ... les ulcères de stress
Fraipont, V.; Lambermont, Bernard ULg; Gast, Pierrette ULg et al

in Revue Médicale de Liège (1998), 53(8), 444-9

Stress related ulcers are superficial and extensive gastric mucosal lesions. They occur in almost all critically ill patients but lead to gastrointestinal bleedings in only 5 to 10%. Endoscopy permits ... [more ▼]

Stress related ulcers are superficial and extensive gastric mucosal lesions. They occur in almost all critically ill patients but lead to gastrointestinal bleedings in only 5 to 10%. Endoscopy permits definitive diagnostic. Stress related mucosal diseases encount for substantial morbidity and mortality. The preventive therapeutic choice depends on efficacy, side effects as cost and nosocomial pneumonia. Sulcralfate appears to be the best choice because of its lower cost, comparable efficacy (sucralfate versus anti-H2) and its lower risk of inducing nosocomial pneumonia. Patients who greatly benefit from prevention, present respiratory failure with at least 48 hours mechanical ventilation, coagulopathy, sepsis or burns. Global management avoiding hypoxia, hypotension and acidosis, takes an important part in the prevention. [less ▲]

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See detailNitric Oxide Downregulates Interleukin 1β (IL-1β) Stimulated IL-6, IL-8, and Prostaglandin E2 Production by Human Chondrocytes
Henrotin, Yves ULg; Zheng, S. X.; Deby, G. P. et al

in Journal of Rheumatology (1998), 25(8), 1595-601

OBJECTIVE: To investigate the effects of endogenously produced nitric oxide (NO) on interleukin 6 (IL-6), IL-8, prostaglandin E2 (PGE2), and proteoglycan production by human chondrocytes. METHODS: Human ... [more ▼]

OBJECTIVE: To investigate the effects of endogenously produced nitric oxide (NO) on interleukin 6 (IL-6), IL-8, prostaglandin E2 (PGE2), and proteoglycan production by human chondrocytes. METHODS: Human articular chondrocytes were isolated from their extracellular matrix by triple successive enzymatic digestion of the cartilage and cultured 48 h in a well defined culture medium. IL-6 and IL-8 were directly assayed into culture media by specific enzyme amplified sensitivity immunoassays. Proteoglycans and PGE2 were quantified by specific radioimmunoassays. Cell culture media were assayed for NO2 using a spectrophotometric assay based upon the Griess reaction. RESULTS: Unstimulated chondrocytes produced low levels of NO, IL-6, IL-8, and PGE2. Production was significantly stimulated by IL-1beta and lipopolysaccharide (LPS). As well, proteoglycan synthesis was profoundly inhibited by IL-1beta and LPS. Inhibition of NO synthesis with the competitive inhibitor NG-monomethyl-L-arginine (L-NMMA) led to enhancement of IL-6, IL-8, and PGE2 production stimulated by either IL-1beta alone or in combination with LPS, whereas the inhibition of proteoglycan production by IL-1beta was not modified by L-NMMA. CONCLUSION: LPS and IL-1beta stimulated IL-6, IL-8, and PGE2 production are downregulated by endogenously produced NO, which could limit the inflammatory reaction occurring in arthritis. [less ▲]

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See detailResponse to 'Comments on Microsporum Canis'
Mignon, Bernard ULg

in Medical Mycology (1998), 36(4), 248

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See detailEffects of Peep on Systemic Venous Capacitance
Lambermont, Bernard ULg; Detry, Olivier ULg; D'Orio, Vincenzo ULg et al

in Archives of Physiology & Biochemistry (1998), 105(4), 373-8

The aim of the present study was to determine effects of positive end expiratory pressure (PEEP) application on peripheral venous capacitance and relate them to concomitant central hemodynamic ... [more ▼]

The aim of the present study was to determine effects of positive end expiratory pressure (PEEP) application on peripheral venous capacitance and relate them to concomitant central hemodynamic disturbances. The venous volume-pressure (V/P) relationships were studied in 6 intact anesthetized pigs to describe the effects of PEEP on systemic venous compliance (computed as the slope of the V/P relationship) and unstressed volume (referred to as the extrapolated volume intercept). Cardiac volumes as well as partitioning of circulating blood volume between central (ITBV) and peripheral (PBV) compartments were assessed by thermo-dye dilution techniques. During a 15 cm H2O PEEP application, venous compliance was reduced by 48%, while unstressed volume was increased by 25% and peripheral blood pooling increased from 63 to 74%. As a result, left heart and right ventricular end diastolic volumes were decreased by 8% and by 44%, respectively. It is concluded that increased venous unstressed volume and reduced compliance depicted the distension of the venous tree secondary to PEEP which acted as an impediment to venous return. As a consequence, cardiac output was reduced because of decreased preload. [less ▲]

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See detailExpression of Growth Factors and Their Receptors in the Postnatal Rat Cochlea
Malgrange, Brigitte ULg; Rogister, Bernard ULg; Lefebvre, P. P. et al

in Neurochemical Research (1998), 23(8), 1133-8

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in ... [more ▼]

RT-PCR was used to assay for growth factors and receptors from seven different protein families in cochlea tissues of the juvenile rat. There was a broad representation of the growth factor families in all the cochlea tissues examined, though the organ of Corti and stria vascularis expressed a greater variety than the spiral ganglion. This broad expression suggests that a variety of known growth factors play significant roles in the development, maintenance, and repair of the inner ear. The results of this survey serve as a basis for the design of future in vitro experiments that will address the ability of growth factors to protect hair cells from damage and to evoke a repair-regeneration response by injured hair cells. [less ▲]

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See detailAn Unconscious Patient with an Electrocardiogram Mimicking an Acute Myocardial Infarct
Lambermont, Bernard ULg; Fraipont, V.; Ghuysen, Alexandre ULg et al

in Postgraduate Medical Journal (1998), 74(874), 499-501

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See detailAbsence of Host Plasminogen Activator Inhibitor 1 Prevents Cancer Invasion and Vascularization
Bajou, Khalid ULg; Noël, Agnès ULg; Gerard, R. D. et al

in Nature Medicine (1998), 4(8), 923-8

Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase ... [more ▼]

Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the plasminogen activation system, including urokinase, but paradoxically also its inhibitor, plasminogen activator inhibitor 1 (PAI1), have been correlated with a poor prognosis for some cancers. We report here that deficient PAI1 expression in host mice prevented local invasion and tumor vascularization of transplanted malignant keratinocytes. When this PAI1 deficiency was circumvented by intravenous injection of a replication-defective adenoviral vector expressing human PAI1, invasion and associated angiogenesis were restored. This experimental evidence demonstrates that host-produced PAI is essential for cancer cell invasion and angiogenesis. [less ▲]

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See detailRepeated Cycles of Retrovirus-Mediated Hsvtk Gene Transfer Plus Ganciclovir Increase Survival of Rats with Peritoneal Carcinomatosis
Princen, Frédéric; Lechanteur, Chantal ULg; Lopez Y Cadenas, Miguel ULg et al

in Gene Therapy (1998), 5(8), 1054-60

Peritoneal carcinomatosis is a common clinical situation that requires novel therapeutic approaches. We investigated the efficiency of an HSVtk gene therapy for the treatment of peritoneal carcinomatosis ... [more ▼]

Peritoneal carcinomatosis is a common clinical situation that requires novel therapeutic approaches. We investigated the efficiency of an HSVtk gene therapy for the treatment of peritoneal carcinomatosis induced in syngeneic rats by DHD/K12 colon carcinoma cells. In this setting, the efficiency of two different retrovirus producing cell lines (GP+AmEnv12 and FLYA13) was compared. Rats treated with a single injection of retrovirus producing cells followed by a 5-day course of ganciclovir treatment showed an increased survival as compared with control animals. Animals treated with three injections of producing cells, each followed by a 4-5-day course of ganciclovir treatment, showed an increased survival as compared with control rats and with those treated with a single cycle of retrovirus producing cells plus ganciclovir. However, only a few animals remained tumor-free after day 180. There was no difference between the two producing cell lines in any of the experiments. RT-PCR demonstrated a faint expression of the tk transgene in the liver, spleen, epiploon, bowels and the lung of the animals injected with the HSVtk producing cells, reflecting most likely the transduction of only a limited number of cells. [less ▲]

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See detailBovine Herpesvirus Type 1 Glycoprotein H Is Essential for Penetration and Propagation in Cell Culture
Meyer, G.; Hanon, E.; Georlette, D. et al

in Journal of General Virology (The) (1998), 79((Pt 8)), 1983-7

Bovine herpesvirus type 1 (BHV-1) glycoprotein H (gH) is a structural component of the virion which forms a complex with glycoprotein gL. To study the role of BHV-1 gH in the virus infectious cycle, a gH ... [more ▼]

Bovine herpesvirus type 1 (BHV-1) glycoprotein H (gH) is a structural component of the virion which forms a complex with glycoprotein gL. To study the role of BHV-1 gH in the virus infectious cycle, a gH null mutant was constructed in which the gH coding sequences were deleted and replaced by the Escherichia coli lacZ cassette. The BHV-1 gH null mutant was propagated in trans-complementing MDBK cells, stably transfected with plasmid pMEP4 containing the BHV-1 gH gene under the control of the inducible mouse metallothionein promoter. Experiments with the BHV-1 gH null mutant showed that gH is essential in the infectious cycle of the virus and is specifically involved in virus entry and cell-to-cell spread. The lack of infectivity of virions devoid of gH is not due to a defect in attachment. Moreover, PEG-induced fusion of virions to target cells provides evidence that BHV-1 gH is required for virion penetration. [less ▲]

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See detailLa reconstruction mammaire
Brewaeys, P.; Heymans, O.; Nizet, Jean-Luc ULg

in Revue Médicale de Liège (1998), 53(8), 483-9

Breast reconstruction has been the subject of many controversies. It now seems generally agreed however that the operation has no deleterious influence on the follow up of breast cancer patients and that ... [more ▼]

Breast reconstruction has been the subject of many controversies. It now seems generally agreed however that the operation has no deleterious influence on the follow up of breast cancer patients and that it has favorable psychologic effects. Breast reconstruction can be performed either by using prostheses or analogous tissues. These two different modalities have each their own advantages and limitations. Deep knowledge of the techniques and their indications allows to select the most appropriate approach in the individual patient and, thus, to improve long term results. [less ▲]

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See detailSuppression of a +1 T Mutation by a Nearby Substitution in the Mitochondrial Cox1 Gene of Chlamydomonas Reinhardtii: A New Type of Frameshift Suppression in an Organelle Genome
Remacle, Claire ULg; Colin, Martine ULg; Matagne, René-Fernand ULg

in Molecular & General Genetics [=MGG] (1998), 259(3), 294-8

In Chlamydomonas reinhardtii, mutants defective in the cytochrome pathway of respiration lack the capacity to grow under heterotrophic conditions (in darkness on acetate). In the dark- strain duM18, a + 1 ... [more ▼]

In Chlamydomonas reinhardtii, mutants defective in the cytochrome pathway of respiration lack the capacity to grow under heterotrophic conditions (in darkness on acetate). In the dark- strain duM18, a + 1 T addition in a run of four Ts, located at codon 145 of the mitochondrial cox1 gene encoding subunit I of cytochrome c oxidase, is responsible for the mutant phenotype. A leaky revertant (su11) that grows heterotrophically at a lower rate than wild-type cells was isolated from dum18. Its respiration sensitivity to cyanide was low and its cytochrome c oxidase activity was only 4% of that of the wild-type enzyme. Meiotic progeny obtained from crosses between revertant and wild-type cells inherited the phenotype of the mt- parent, showing that the suppressor mutation, like dum18 itself, is located in the mitochondrial genome. In order to map the su11 mutation relative to dum18, a recombinational analysis was performed on the diploid progeny. It demonstrated that su11 was very closely linked to the dum18 mutation less than 20-30 bp away. The cox1 gene of the su11 revertant was then sequenced. In addition to the + 1 T frameshift mutation still present at codon 145, an A-->C substitution was found at codon 146, leading to the replacement of a glutamic acid by an alanine in the polypeptide chain. No other mutations were detected in the cox1 coding sequence. As the new GCG codon (Ala) created at position 146 is very seldom used in the mitochondrial genome of C. reinhardtii, we suggest that the partial frameshift suppression by the nearby substitution is due to an occasional abnormal translocation of the ribosome (+ 1 base shift) facilitated both by the run of Ts and the low level of weak interaction of alanyl-tRNA. [less ▲]

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See detailThe Role of Early Measurement of Nitrogen-13 Ammonia Uptake for Predicting Contractile Recovery after Acute Myocardial Infarction
LANCELLOTTI, Patrizio ULg; Melon, P. G.; de Landsheere, C. M. et al

in International Journal of Cardiac Imaging (1998), 14(4), 261-7269-70

Previous studies have shown that the maintenance of cell membrane integrity and metabolism requires the persistence of residual myocardial blood flow. The purpose of this study was to assess the role of N ... [more ▼]

Previous studies have shown that the maintenance of cell membrane integrity and metabolism requires the persistence of residual myocardial blood flow. The purpose of this study was to assess the role of N-13 ammonia positron emission tomographic (PET) imaging performed early after an acute myocardial infarction for predicting functional recovery. Seventeen patients with an acute myocardial infarction were included in the study. Thirteen received thrombolytic therapy, 2 underwent immediate angioplasty of the infarct-related artery and 2 were treated with heparin. N-13 ammonia imaging was performed 6 +/- 2 days after the acute event and was followed by elective angioplasty in 13 patients. Using a 16-segment polar map display, regional N-13 ammonia uptake was expressed as a percentage of maximal segmental uptake and classified as normal (> 63%), moderately reduced (63-50%) and severely reduced (< 50%) based on values of tracer uptake obtained from healthy subjects. By echocardiographic assessment of regional wall thickening within 96 hours and at 1 month after the infarct, we examined the relationship between blood flow and functional outcome of myocardial segments in the infarct-related area. Regional wall thickening was graded on a 4-point scale: normal (1), hypokinesia (2), akinesia (3) and dyskinesia (4). Of 77 dyssynergic segments at baseline echocardiographic study, 43 had normal flow, 15 moderately reduced flow and 19 severely reduced flow. Segments with N-13 ammonia uptake > or = 50% demonstrated a significant improvement in wall thickening score at follow-up (p < 0.001), whereas segments with N-13 ammonia uptake < 50% showed no improvement in wall thickening scores (p < 0.001). The proportion of segments improving contractility by at least 1 score was significantly higher in the group of segments with N-13 ammonia uptake > 63%. The predictive value for defining functional recovery with segmental N-13 ammonia uptake > 63% was 86%. The predictive value for absence of recovery (uptake < 50%) was 54%. In conclusion, our data showed that early after an acute myocardial infarction N-13 ammonia imaging provides information regarding functional outcome. [less ▲]

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See detailCytokine Expression in Squamous Intraepithelial Lesions of the Uterine Cervix: Implications for the Generation of Local Immunosuppression
Giannini, Sandra; Al-Saleh, Walid; Piron, Hélène ULg et al

in Clinical & Experimental Immunology (1998), 113(2), 183-9

We have addressed the notion that the progression of cancer of the uterine cervix is associated with a preferential constraint on the development of a type 1 cellular mediated response, which is necessary ... [more ▼]

We have addressed the notion that the progression of cancer of the uterine cervix is associated with a preferential constraint on the development of a type 1 cellular mediated response, which is necessary to efficiently eliminate (pre)neoplastic cells. Based on the importance of cytokines in the regulation of an appropriate immune response, we have evaluated the expression of IL-12p40, IL-10 and transforming growth factor-beta 1 (TGF-beta1). Using reverse transcriptase-polymerase chain reaction (RT-PCR), the expression of these three cytokines was evaluated in both low-grade (LG) and high-grade (HG) cervical squamous intraepithelial lesions (SIL) and in normal exocervix and transformation zone biopsies. Our results show that the average level of IL-12 increases within both the LG and HG SIL, compared with both control groups. Interestingly, the percentage of HG SIL expressing IL-12p40 was lower compared with LG SIL. In contrast, the expression of IL-10 increased in parallel with the severity of the lesion to a maximal level in HG SIL. Using immunohistochemistry, we ascertained the presence of IL-12 protein in SIL and IL-10 protein in the transformation zone and SIL biopsies. Both IL-12- and IL-10-producing cells were localized in the stroma, not within the SIL. Furthermore, in this study we also observed that the region of the cervix the most sensitive to lesion development, the transformation zone, was associated with higher average levels of the immunosuppressive cytokines IL-10 and TGF-beta1. [less ▲]

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See detailEarly and late onset manifestations of cerebral vasculitis related to varicella zoster.
Hausler, M. G.; RAMAEKERS, Vincent ULg; Reul, J. et al

in Neuropediatrics (1998), 29(4), 202-7

Varicella-zoster associated cerebral vasculitis (VZCV) as a cause of cerebral infarction has hitherto been considered a rare condition. Ischemic stroke in previously healthy children has occurred during ... [more ▼]

Varicella-zoster associated cerebral vasculitis (VZCV) as a cause of cerebral infarction has hitherto been considered a rare condition. Ischemic stroke in previously healthy children has occurred during recovery from chickenpox or has been attributed to virus reactivation among immunosuppressed patients. The clinical, radiologic and immunologic findings in four children with VZCV will be reported. Clinical manifestations included sudden onset of hemiparesis, motor aphasia and disturbed consciousness in previously healthy children. Only one child had a history of chickenpox six weeks prior to the onset of stroke, whereas a latency period of up to four years between chickenpox and the onset of stroke was found in the other three children. Diagnosis of VZCV was confirmed repeatedly by demonstrating intrathecal production of varicella-zoster IgG antibodies in three children or a four-fold increase of varicella-zoster serum IgA-antibodies in one child. Intrathecal production of antibodies against other latent viruses and borreliosis could be excluded. PCR for varicella on CSF, performed in two patients, remained negative. No intrathecal production of varicella-zoster antibodies has been found in a control group of twenty clinically healthy children (age range from 2-18 years) with a previous varicella infection. During follow-up two children recovered completely whereas two children still suffer from serious neurological deficits. Immunological investigations, performed in three children, showed circulating immune-complexes with slightly lowered complement concentrations in two patients. In addition a lowered T-helper/T-suppressor cell ratio of unknown origin was found in three children. These immunological findings will be discussed in the light of the pathophysiology of VZCV. [less ▲]

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See detailEctopic Expression of Bone Sialoprotein in Human Thyroid Cancer
Bellahcene, Akeila ULg; Albert, V.; Pollina, L. et al

in Thyroid (1998), 8(8), 637-41

Bone sialoprotein (BSP) is a small, highly posttranslationally modified integrin binding protein found in the mineral compartment of developing bone. The recent discovery that BSP can be detected in a ... [more ▼]

Bone sialoprotein (BSP) is a small, highly posttranslationally modified integrin binding protein found in the mineral compartment of developing bone. The recent discovery that BSP can be detected in a variety of human cancers, particularly those that metastasize preferentially to the skeleton, shed light on potential new biological functions for this protein. The demonstration of a positive association between BSP expression in primary breast tumors and the development of bone metastases suggests that this glycoprotein could play a role in the selective implantation of breast cancer cells in bone. BSP is also expressed in most lung and prostate cancers as well as in multiple myeloma, three other osteotropic malignancies. Because thyroid carcinoma also metastasizes preferentially to the skeleton, we decided to look at the expression of BSP in a collection of 145 thyroid malignant lesions including 24 follicular thyroid carcinomas (FTCs), 55 papillary thyroid carcinomas (PTCs), 19 medullary thyroid carcinomas (MTCs), 23 anaplastic carcinomas (ACs), and 24 poorly differentiated carcinomas (PDCs). BSP expression was evaluated by immunoperoxidase technique using two specific polyclonal antibodies. Most of the thyroid carcinomas (72%) examined expressed high levels of BSP. Expression of BSP was significantly lower in FTCs and MTCs compared with PDCs, which are more aggressive (p = 0.0009 and 0.0003, respectively). Our study demonstrates for the first time that ectopic BSP expression is a common feature of thyroid cancer. The prognostic value of BSP detection in thyroid adenocarcinoma and the potential role of BSP in the propension of this type of cancer to metastasize to bone are currently under investigation. [less ▲]

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See detailLaryngeal Rhabdomyoma in a Golden Retriever
Clercx, Cécile ULg; Desmecht, Daniel ULg; Michiels, L. et al

in Veterinary Record : Journal of the British Veterinary Association (1998), 143(7), 196-8

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the ... [more ▼]

A three-year-old male golden retriever had had progressive dyspnoea, exercise intolerance, stridor, and a modified bark for five months. A mass 2 cm in diameter was present dorsal to the right side of the larynx. Histological examination revealed cross-striations in some elongated cells, consistent with a diagnosis of rhabdomyoma, a diagnosis which was confirmed by positive immunohistochemical staining for myoglobin and desmin. The mass could not be removed without total laryngectomy and a permanent tracheostomy and the dog was euthanased. [less ▲]

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See detailCluster Headaches--Central or Peripheral in Origin?
Schoenen, Jean ULg

in Lancet (1998), 352(9124), 253-5

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See detailHigh-Resolution Optical and Near-Infrared Imaging of the Quadruple Quasar RX J0911.4+0551
Burud, I.; Courbin, F.; Lidman, C. et al

in Astrophysical Journal (1998), 501

We report the detection of four images in the recently discovered lensed QSO RX J0911.4+0551. With a maximum angular separation of 3."1, it is the quadruply imaged QSO with the widest known angular ... [more ▼]

We report the detection of four images in the recently discovered lensed QSO RX J0911.4+0551. With a maximum angular separation of 3."1, it is the quadruply imaged QSO with the widest known angular separation. Raw and deconvolved data reveal an elongated lens galaxy. The observed reddening in at least two of the four QSO images suggests differential extinction by this lensing galaxy. We show that both an ellipticity of the galaxy ( epsilon _{{min}}=0.075 ) and an external shear ( gamma _{{min}}=0.15 ) from a nearby mass have to be included in the lensing potential in order to reproduce the complex geometry observed in RX J0911.4+0551. A possible galaxy cluster is detected about 38" from RX J0911.4+0551 and could contribute to the X-ray emission observed by ROSAT in this field. The color of these galaxies indicates a plausible redshift in the range of 0.6-0.8. [less ▲]

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See detailThe Effect of Sodium Monofluorophosphate Plus Calcium on Vertebral Fracture Rate in Postmenopausal Women with Moderate Osteoporosis. A Randomized, Controlled Trial
Reginster, Jean-Yves ULg; Meurmans, L.; Zegels, Brigitte ULg et al

in Annals of Internal Medicine (1998), 129(1), 1-8

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are ... [more ▼]

BACKGROUND: Fluoride is effective in increasing trabecular bone mineral density (BMD) in the spine, but its efficacy in reducing vertebral fracture rates and its effect on BMD at cortical sites are controversial. OBJECTIVE: To study the effect of low-dose fluoride (sodium monofluorophosphate [MFP]) plus a calcium supplement over 4 years on vertebral fractures and BMD at the lumbar spine and total hip in postmenopausal women with moderately low BMD of the spine. DESIGN: Randomized, double-blind, controlled clinical trial. SETTING: Outpatient clinic for osteoporosis at a university medical center. PATIENTS: 200 postmenopausal women with osteoporosis (according to the World Health Organization definition) and a T-score less than -2.5 for BMD of the spine. INTERVENTION: Women were randomly assigned (100 patients per group) to continuous daily treatment for 4 years with 1) oral MFP (20 mg of equivalent fluoride) plus 1000 mg of calcium (as calcium carbonate) or 2) calcium only. MEASUREMENTS: Lateral spine radiographs were taken at enrollment and at each year of follow-up for detection of new vertebral fractures (defined as a reduction > or =20% and > or =4 mm from baseline in any of the heights of a vertebral body). Nonvertebral fractures were also recorded. All analyses were done with the intention-to-treat approach. RESULTS: Radiologic follow-up was possible for 164 of 200 patients (82%). The rate of new vertebral fractures during the 4 years of the study was lower in the MFP-plus-calcium group (2 of 84 patients; 2.4% [95% CI, 0.3% to 8.3%]) than in the calcium-only group (8 of 80 patients; 10% [CI, 4.4% to 18.8%]). The difference between the groups was 7.6 percentage points (CI, 0.3 to 15 percentage points) (P = 0.05). A moderate but progressive increase in BMD of the spine (10.0% +/- 1.5% at 4 years) was found for MFP plus calcium compared with calcium only (P < 0.001), whereas the more modest increase in BMD of the total hip seen with MFP plus calcium (1.8% +/- 0.6%) did not differ from the increase seen with calcium only. CONCLUSIONS: Low-dose fluoride (20 mg/d) given continuously with calcium for prolonged periods can decrease vertebral fracture rates compared with calcium alone in patients with mild to moderate osteoporosis. [less ▲]

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See detailSpectral evolution of Rosetta target comet 46P/Wirtanen
Schulz, R.; Arpigny, Claude ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (1998), 335

The compositional evolution of the coma of Rosetta target comet 46P/Wirtanen was studied along its pre-perihelion orbit. At 2.34 AU the first gaseous species, CN and C_3, were detected. C_2 and NH_2 arose ... [more ▼]

The compositional evolution of the coma of Rosetta target comet 46P/Wirtanen was studied along its pre-perihelion orbit. At 2.34 AU the first gaseous species, CN and C_3, were detected. C_2 and NH_2 arose at 2.0 AU. The production rate curves of gas and dust show a steep increase between 1.8 AU and 1.6 AU indicating a distinct change of the outgassing conditions. The C_2 production increases more rapidly with decreasing solar distance than CN. As one consequence the C_2/CN ratio strongly varies with heliocentric distance. Due to this variation a classification of 46P/Wirtanen by the taxonomy introduced by A'Hearn et al. (\cite{AMSOB}) distinguishing comets with typical abundance ratios from carbon-chain depleted comets, is impossible. It would be classified as depleted beyond about 1.6 AU whereas it would be designated typical at smaller distances. The knowledge of the unexpected changes in the activity curves of 46P/Wirtanen will help to optimize the Rosetta mission scenario in particular with regard to science operations. based on observations obtained at ESO La Silla within ESO programmes No. 57.F-0290 and 58.F-0413 [less ▲]

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See detailPrognostic Value of Bone Sialoprotein Expression in Clinically Localized Human Prostate Cancer
Waltregny, David ULg; Bellahcene, Akeila ULg; Van Riet, Ivan et al

in Journal of the National Cancer Institute (1998), 90(13), 1000-8

BACKGROUND: Bone sialoprotein (BSP), a bone matrix protein, was recently found to be expressed ectopically in breast cancer and to have a statistically significant association with poor prognosis and the ... [more ▼]

BACKGROUND: Bone sialoprotein (BSP), a bone matrix protein, was recently found to be expressed ectopically in breast cancer and to have a statistically significant association with poor prognosis and the development of bone metastases in that disease. These data prompted us to investigate whether BSP might also be expressed in human prostate cancer, which often metastasizes to bone, and be predictive for progression risk. METHODS: Tissue sections from 180 patients who had undergone a radical prostatectomy for localized prostate cancer were analyzed immunohistochemically for BSP expression. Biochemical progression was defined as an increasing serum prostate-specific antigen level of 0.5 ng/mL or more. Statistical analysis was used to assess associations between pathologic findings and level of BSP expression, and a Cox proportional hazards model was used to determine which clinical and histologic parameters, including stage, Gleason score, and BSP expression (immunostaining intensity and extent), were independently associated with biochemical progression. All P values were two-sided. RESULTS: Most of the prostate cancer lesions examined (78.9%) expressed detectable levels of BSP, compared with no or low expression in the adjacent normal glandular tissue. A statistically significant association was found between BSP expression and biochemical progression in both univariate and multivariate analyses. After a follow-up interval of 3 years, the biochemical relapse rate was 36.7% (95% confidence interval [CI] = 23.4%-47.7%) in patients whose tumors expressed high levels of BSP compared with 12.1% (95% CI = 2.3%-20.8%) in patients whose tumors expressed no or a low detectable level of the protein (logrank test, P = .0014). BSP expression status could identify those patients at higher risk of biochemical progression (logrank test, P<.05) among patients with moderately differentiated tumors or with pathologically confined tumors. CONCLUSIONS: To our knowledge, this study is the first to demonstrate BSP expression in human prostate cancer and to highlight the protein's statistically significant prognostic value in patients with clinically confined prostate adenocarcinomas. [less ▲]

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See detailLine profile variability in the spectrum of the O(f) supergiant HD 192639
Rauw, Grégor ULg; Vreux, Jean-Marie ULg

in Astronomy and Astrophysics (1998), 335

We report the results of a medium-resolution spectroscopic investigation of the O(f) supergiant HD 192639. Particular attention is paid to the He {ii}\ lambda 4686 line. This line displays strong profile ... [more ▼]

We report the results of a medium-resolution spectroscopic investigation of the O(f) supergiant HD 192639. Particular attention is paid to the He {ii}\ lambda 4686 line. This line displays strong profile variability on time scales of a few days, changing from a P-Cygni profile with a double-peaked emission component to a pure blue-shifted emission line. It appears that the variability of most of the absorption lines present in our spectra is correlated to the deformation of the He {ii}\ lambda 4686 line and arises probably from a large scale structure in the low-velocity part of the stellar wind rather than from a photospheric phenomenon. We find that the time scale of the variability could be consistent with the estimated rotational period of HD 192639. Based on observations collected at the Observatoire de Haute Provence, France. [less ▲]

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See detailImmunological Status of Competitive Football Players During the Training Season
Bury, Thierry ULg; Marechal, R.; Mahieu, P. et al

in International Journal of Sports Medicine (1998), 19(5), 364-8

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T ... [more ▼]

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T-lymphocyte proliferation, NK activity, chemotaxis and phagocytosis of neutrophils. Training and competitions did not produce any change in the total number of leucocytes but increased neutrophil counts and decreased T4 lymphocyte counts. We also observed a slight decrease of T-lymphocyte proliferation and a significant decrease of neutrophil functions. On the other hand, training and competitions did not induce significant changes in the number of NK cells nor in the total NK cytotoxic activity. The different change observed tended to normalize after the sports season. Our results suggest a predominant neutrophil function depression in football players during a training season which could partly explain the susceptibility of elite athletes to infections. [less ▲]

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See detailEndocrinology of pregnancy: chorionic somatomammotropins and pregnancy-associated glycoproteins: review
Beckers, Jean-François ULg; Zarrouk, Anissa; Batalha, Evie S et al

in Acta Veterinaria Hungarica (1998), 46(2), 175-189

The two main groups of placental proteins of ruminants are discussed in this paper: chorionic somatomammotropins (placental lactogens) and pregnancy-specific (-associated) proteins. Placental lactogens ... [more ▼]

The two main groups of placental proteins of ruminants are discussed in this paper: chorionic somatomammotropins (placental lactogens) and pregnancy-specific (-associated) proteins. Placental lactogens belong to the prolactin and growth hormone family. They stimulate mammogenesis, fetal growth and maternal metabolism. Pregnancy-specific proteins and pregnancy-associated glycoproteins belong to the aspartic proteinase family like pepsin, cathepsin D and E. These two groups of proteins are secretd in the maternal circulation by the binucleate cells after their migration to and fusion with the uterine cells. Theirs profiles were determined by radioimmunoassay (RIA). Further investigations are in progress to related secretory profiles with alterations of the trophoblastic function such as those occuring in embryonic mortality, abortion, and fetal distress. The endocrine function of the primate and equine palcenta is also discussed. [less ▲]

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See detailSynthesis of novel polymeric materials based on aliphatic polyesters by combination of different controlled polymerization methods
Jérôme, Robert ULg; Mecerreyes, David; Tian, Dong et al

in Macromolecular Symposia (1998), 132

Combination of the living ring-opening polymerization (ROP) of ε-CL and lactides with the "controlled" free radical polymerization of styrene and methacrylic monomers is a versatile strategy for the ... [more ▼]

Combination of the living ring-opening polymerization (ROP) of ε-CL and lactides with the "controlled" free radical polymerization of styrene and methacrylic monomers is a versatile strategy for the synthesis of well-defined block and graft copolymers. In this respect, the dual "living" polymerization strategy in which two different functional groups on a single molecule used to initiate the two controlled mechanisms is particularly efficient. Combination of ROP and step-growth polymerization is another versatile methodology for the preparation of a large variety of new materials, e.g. polyimide nanofbams, polyester/silica hybrid materials and star and branched polyesters by dendritic initiation. [less ▲]

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See detailHyperactivity in the low sternal region with Tc-99m sestamibi: possible cardiac origin
Servais, Fabienne; Seret, Alain ULg; Blocklet, Didier et al

in Clinical Nuclear Medicine (1998), 23(7), 461-462

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal ... [more ▼]

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal hyperactivity on anterior views could arise from the myocardium. Caution therefore should be taken before the diagnosing of any hyperactivity in the lower sternal region as a neoplastic involvement. [less ▲]

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