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See detailRecommandations a propos du traitement de l'hypertension arterielle chez le patient diabetique.
Scheen, André ULg; Rorive, Marcelle ULg; Estrella, F. et al

in Revue Médicale de Liège (2000), 55(5), 376-82

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy ... [more ▼]

Diabetes mellitus is frequently associated with arterial hypertension and the combination of the two entities markedly increases the cardiovascular risk and accelerates the progression of microangiopathy (more particularly nephropathy) in both type 1 and type 2 diabetic patients. Numerous international guidelines have been published during the last few years to help the practitioner in targeting ideal arterial blood pressure levels (lower in diabetic than in non-diabetic patients) and in selecting first-choice antihypertensive agents. We will concisely summarize the main messages of these recommendations and insist upon the persistence of uncertainties, or even the existence of inconsistencies, more particularly regarding preferential indications of antihypertensive agents in diabetic patients. [less ▲]

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See detailLes affections du système urinaire du chat : I. Insuffisance rénale chronique : aspects diététiques.
Jeusette, I.; Cremer, V.; Istasse, Louis ULg et al

in Annales de Médecine Vétérinaire (2000), 144

This paper aims to present the nutritional requirements of cats suffering from chronic renal failure, the most common condition in renal pathology. Indeed, the concept consisting in a reduced protein ... [more ▼]

This paper aims to present the nutritional requirements of cats suffering from chronic renal failure, the most common condition in renal pathology. Indeed, the concept consisting in a reduced protein content diet is a little out of date. Renal anatomy and function are reviewed as well as the main renal pathologies. Incidence, symptoms, diagnosis and overall dietary management are developed. The different nutrients to be taken into consideration are discussed, according to the evolution's state of the disease. Finally, a comparison between different pet foods for chronic renal failure shows a largely variable composition and should help the practitioner to make the best choice for its patient. Home made food are also proposed. [less ▲]

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See detailL'image du mois. Thrombose de la veine porte
Ancion, G.; Delwaide, Jean ULg; Boverie, Jacques ULg

in Revue Médicale de Liège (2000), 55(8), 761-762

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See detailProton re-uptake partitioning between uncoupling protein and ATP synthase during benzohydroxamic acid-resistant state 3 respiration in tomato fruit mitochondria.
Jarmuszkiewicz, W.; Almeida, A.; Vercesi, A. et al

in Journal of Biological Chemistry (2000), 275(18), 13315-13320

The yield of oxidative phosphorylation in isolated tomato fruit mitochondria depleted of free fatty acids remains constant when respiratory rates are decreased by a factor of 3 by the addition of n-butyl ... [more ▼]

The yield of oxidative phosphorylation in isolated tomato fruit mitochondria depleted of free fatty acids remains constant when respiratory rates are decreased by a factor of 3 by the addition of n-butyl malonate. This constancy makes the determination of the contribution of the linoleic acid-induced energy-dissipating pathway by the ADP/O method possible. No decrease in membrane potential is observed in state 3 respiration with increasing concentration of n-butyl malonate, indicating that the rate of ATP synthesis is steeply dependent on membrane potential. Linoleic acid decreases the yield of oxidative phosphorylation in a concentration-dependent manner by a pure protonophoric process like that in the presence of FCCP. ADP/O measurements allow calculation of the part of respiration leading to ATP synthesis and the part of respiration sustained by the dissipative H(+) re-uptake induced by linoleic acid. Respiration sustained by this energy-dissipating process remains constant at a given LA concentration until more than 50% inhibition of state 3 respiration by n-butyl malonate is achieved. The energy dissipative contribution to oxygen consumption is proposed to be equal to the protonophoric activity of plant uncoupling protein divided by the intrinsic H(+)/O of the cytochrome pathway. It increases with linoleic acid concentration, taking place at the expense of ADP phosphorylation without an increase in the respiration. [less ▲]

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See detailGas Phase Thermal Denaturation of an Oligonucleotide Duplex and Its Complexes with Minor Groove Binders
Gabelica, Valérie ULg; Rosu, Frédéric ULg; Houssier, Claude ULg et al

in Rapid Communications in Mass Spectrometry : RCM (2000), 14(6), 464-467

Electrospray ionization with in-source collisionally induced dissociation has been used to probe the gas phase stability of an oligonucleotide duplex and its complexes with some minor groove binding drugs ... [more ▼]

Electrospray ionization with in-source collisionally induced dissociation has been used to probe the gas phase stability of an oligonucleotide duplex and its complexes with some minor groove binding drugs. On the basis of the arguments developed in detail by Drahos et al. (J. Mass Spectrom. 1999; 34:1373), this type of experiment can also be described as 'thermal denaturation in the gas phase'. We found that the gas phase denaturation curves were very similar to the solution phase denaturation curves determined by the traditional UV spectrophotometric method and, by analogy with the melting temperature T(m) which characterizes the stability in solution, we define a melting voltage V(m) to characterize the stability in the gas phase. A comparison of the T(m) and V(m) relative values suggests that the structure of the complexes is conserved during the electrospray process which transfers the ions from the solution to the gas phase. [less ▲]

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See detailPathological Findings in Two Fin Whales (Balaenoptera Physalus) with Evidence of Morbillivirus Infection
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Journal of Comparative Pathology (2000), 123(2-3, Aug-Oct), 198-201

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one ... [more ▼]

Two immature female fin whales stranded on the Belgian and French coastlines, were examined post mortem. The main gross findings were massive parasitic infestation, associated with a large thrombus in one whale, and severe emaciation. Microscopical investigations revealed multinucleated syncytia with large intranuclear inclusion bodies in various tissues, and positive immunolabelling for morbillivirus antigens. Other evidence of morbillivirus infection was provided by the demonstration of specific viral structures in syncytia and in cell cultures, and the detection of neutralizing antibodies to canine distemper virus. To the authors>> knowledge, this is the first firm report of morbillivirus infection in baleen whales. [less ▲]

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See detailA comparison of the haemodynamic effects of isoflurane and halothane anaesthesia in horses
Raisis, Anthea L; Young, L. E.; Blissitt, K. J. et al

in Equine Veterinary Journal (2000), 32(4), 318-326

The purpose of this study was to compare the haemodynamic effects of equipotent isoflurane and halothane anaesthesia. Six adult horses were investigated on two separate occasions at least 4 weeks apart ... [more ▼]

The purpose of this study was to compare the haemodynamic effects of equipotent isoflurane and halothane anaesthesia. Six adult horses were investigated on two separate occasions at least 4 weeks apart. On both occasions anaesthesia was induced by ketamine 2.2 mg/kg bwt given 5 min after i.v. administration 100 microg/kg bwt romifidine. Anaesthesia was maintained either by halothane or isoflurane (end-tidal concentrations 0.9-1.0% and 1.3-1.4%, respectively). Horses were ventilated by intermittent positive pressure to maintain PaCO2 between 40-50 mmHg. Haemodynamic variables were measured using catheter-mounted strain gauge transducers in the left and right ventricle, aorta, and right atrium. Cardiac output (CO), velocity time integral (VTI), maximal aortic blood flow velocity (Vmax) and acceleration (dv/dt(max)), left ventricular pre-ejection period (PEP) and ejection time (ET) were measured from aortic blood flow velocity waveforms obtained by transoesophageal Doppler echocardiography. Flow velocity waveforms were recorded from the femoral arteries and veins using low pulse repetition frequency Doppler ultrasound. Time-averaged mean velocity (TAV), velocity of component a (TaVa), velocity of component b (TaVb) and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular blood flow was measured in the left and right semimembranosus muscles by laser Doppler flowmetry. Maximal rate of rise of LV pressure (LVdp/dt(max)), CO, Vmax, dv/dt(max), ET, VTI were significantly higher at all time points during isoflurane anaesthesia compared to halothane anaesthesia. Pre-ejection period and diastolic aortic blood pressure were significantly less throughout isoflurane anaesthesia compared to halothane. Isoflurane anaesthesia was associated with significantly lower systemic vascular resistance than halothane anaesthesia. Femoral arterial and venous blood flow were significantly higher and EDDS and PI were significantly lower during isoflurane anaesthesia compared to halothane anaesthesia. In addition during both halothane and isoflurane anaesthesia, femoral arterial flow was higher and EDDS and PI lower in the left (dependent) artery compared to the right (nondependent) artery. This study supports previous work demonstrating improved left ventricular systolic function during isoflurane compared to halothane anaesthesia. This improvement was still evident after premedication with a potent-long acting alpha2-adrenoreceptor agonist, romifidine, and induction of anaesthesia with ketamine. There was also evidence of increased hindlimb blood flow during isoflurane anaesthesia. However, there were differences observed in flow between the left and right hindlimb during maintenance of anaesthesia with each agent, suggesting that there were differences in regional perfusion in anaesthetised horses caused by factors unrelated to agents administered [less ▲]

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See detailRecommandations pour le traitement de l'obesite.
Luyckx, Françoise ULg; Scheen, André ULg

in Revue Médicale de Liège (2000), 55(5), 367-71

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual ... [more ▼]

Obesity represents a major medical problem which is now considered more seriously from a scientific, clinical and economical point of view. Such an evolution was mandatory when considering the usual contempt for what is now considered as a chronic disease and especially the charlatanism which was observed among medical and non-medical spheres. Hence, as for numerous other pathologies, international guidelines have recently been published to optimize the management of obesity, from the view point of efficacy and, more particularly, safety. We will summarize the main recommendations as far as diet and physical treatment, pharmacotherapy and bariatric surgery are concerned. Finally, we will briefly describe general guidelines on the management of obese subjects taking into account the degree of weight excess and the presence of complications. [less ▲]

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See detailEffect of pH on CN-resistant respiratory activity and regulation on Vigna uniguiculata mitochondria
Lima-junior, A.; Fernandes de melo, D.; Costa, J. H. et al

in Plant Physiology & Biochemistry (2000), 38

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See detailLong-Term Protection Against Bovine Leukaemia Virus Replication In Cattle And Sheep
Kerkhofs, P.; GATOT, Jean-Stéphane ULg; Knapen, K. et al

in Journal of General Virology (2000), 81

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See detailNon-aqueous capillary electrophoretic enantioseparation of N-derivatized amino acids using cinchona alkaloids and derivatives as chiral counter-ions.
Piette, Véronique; Fillet, Marianne ULg; Lindner, W. et al

in Journal of Chromatography. A (2000), 875(1-2), 353-60

A non-aqueous capillary electrophoretic method developed with quinine and tert.-butyl carbamoylated quinine as chiral selectors for the enantioseparation of N-protected amino acids was applied to the ... [more ▼]

A non-aqueous capillary electrophoretic method developed with quinine and tert.-butyl carbamoylated quinine as chiral selectors for the enantioseparation of N-protected amino acids was applied to the investigation of other quinine derivatives as chiral additives. The optimum composition of the background electrolyte was found to be 12.5 mM ammonia, 100 mM octanoic acid and 10 mM chiral selector in an ethanol-methanol (60:40, v/v) mixture. Under these conditions, a series of chiral acids, as various benzoyl, 3,5-dinitrobenzoyl and 3,5-dinitrobenzyloxycarbonyl amino acid derivatives were investigated with regards to selectand-selector relationships and enantioselectivity employing quinine, quinidine, cinchonine, cinchonidine, tert.-butyl carbamoylated quinine, tert.-butyl carbamoylated quinidine, dinitrophenyl carbamoylated quinine and cyclohexyl carbamoylated quinine as chiral selector. [less ▲]

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See detailComment je traite.... De la pharmacologie speciale a la therapeutique medicale: plaidoyer pour un enseignement privilegiant l'apprentissage au raisonnement therapeutique, de la decision a la prescription.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 811-6

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important ... [more ▼]

Clinical pharmacology and therapeutics are two complementary disciplines which should lead the medical student, through an optimized training, to a rational prescription of drugs, ultimate and important step of the medical approach. Such a learning should occur progressively throughout the medical education, focusing, first, on the therapeutic reasoning ("why?") and, second, on the practical application leading to the prescription ("how?"). The medical student should learn the difficult task of integrating disease, drug and patient, in order to optimize the benefit/risk ratio, while being informed about new concepts such as "Evidence-Based Medicine" and pharmacoeconomics. [less ▲]

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See detailAn Appraisal of 18-Fluorodeoxyglucose Positron Emission Tomography for Melanoma Staging
Paquet, Philippe ULg; Henry, Frédérique ULg; Belhocine, Tarik et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2000), 200(2), 167-9

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To ... [more ▼]

BACKGROUND: Positron emission tomography (PET scan) using fluorodeoxyglucose (FDG) is increasingly recognized as a reliable diagnostic method to detect metastases of malignant melanoma (MM). OBJECTIVE: To compare the diagnostic performance of 18-FDG PET scan to that of conventional imaging. METHODS: A total of 28 assessments were conducted in 24 patients at risk of metastatic MM. Results: The diagnostic accuracy was over 80% and similar for PET scan and conventional imaging. CONCLUSION: Both the specificity and sensitivity of PET scan are high although not perfect. Confrontation of data with anatomical location and clinicopathological findings remains mandatory. [less ▲]

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See detailSpondylolyse bilatérale: intérêt de la tomoscintigraphie osseuse.
Blocklet, Didier; Seret, Alain ULg; Schoutens, André

in Revue Médicale de Bruxelles (2000), 21

Clinical case.

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See detailEffect of a 30-minute infusion of dobutamine hydrochloride on hind limb blood flow and hemodynamics in halothane-anesthetized horses
Raisis, Anthea L; Young, Lesley E; Blissitt, Karen J et al

in American Journal of Veterinary Research (2000), 61(10), 1282-1288

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia ... [more ▼]

OBJECTIVE: To evaluate the hemodynamic effects of dobutamine hydrochloride (0.5 microg/kg of body weight/min) in halothane-anesthetized horses. ANIMALS: 6 adult Thoroughbred horses. PROCEDURE: Anesthesia was induced by use of romifidine (100 microg/kg) and ketamine (2.2 mg/kg), IV. Anesthesia was maintained by halothane (end-tidal concentration 0.9 to 1.0%). Aortic, left ventricular, and right atrial pressures were measured, using catheter-mounted strain gauge transducers. Cardiac output (CO), velocity time integral, maximal aortic blood flow velocity and acceleration, and left ventricular preejection period and ejection time were measured from aortic velocity waveforms obtained by transesophageal Doppler echocardiography. Velocity waveforms were recorded from the femoral vessels, using Doppler ultrasonography. The time-averaged mean velocity and early diastolic deceleration slope (EDDS) were measured. Pulsatility index (PI) and volumetric flow were calculated. Microvascular perfusion was measured in the semimembranosus muscles by laser Doppler flowmetry. Data were recorded 60 minutes after induction of anesthesia (control) and at 15 and 30 minutes after start of an infusion of dobutamine (0.5 microg/kg/min). RESULTS: Aortic pressures were significantly increased during the infusion of dobutamine. No change was observed in the indices of left ventricular systolic function including CO. Femoral arterial flow significantly increased, and the PI and EDDS decreased. No change was observed in the femoral venous flow or in microvascular perfusion. CONCLUSIONS AND CLINICAL RELEVANCE: At this dosage, dobutamine did not alter left ventricular systolic function. Femoral blood flow was preferentially increased as the result of local vasodilatation. The lack of effect of dobutamine on microvascular perfusion suggests that increased femoral flow is not necessarily associated with improved perfusion of skeletal muscles [less ▲]

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See detailPolitique et usage des manuels scolaires en mathématiques et en sciences
Monseur, Christian ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 177-183

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See detailEnantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.
Piette, Véronique; Fillet, Marianne ULg; Lindner, W. et al

in Biomedical Chromatography : BMC (2000), 14(1), 19-21

Enantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.

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See detailMonitoring des animaux vivants : exemple d’un échantillonnage pour la détection des PCBs et des dioxines chez les bovins de boucherie en Belgique
Saegerman, Claude ULg; Boelaert, F.; Van Vlanderen, I. et al

in Epidémiologie et Santé Animale (2000), 38

In February 1999, a poisoning episode broke out in several industrial poultry farms in Belgium. The source of this contamination was found to be a stock of recycled fat that had been delivered by a firm ... [more ▼]

In February 1999, a poisoning episode broke out in several industrial poultry farms in Belgium. The source of this contamination was found to be a stock of recycled fat that had been delivered by a firm to several compound feed producers, between 19 and 31 January 1999. A very good correlation was observed between dioxins (PCDFs and PCDDs) and PCBs. Consequently a contamination mainly by PCBs was hypothesized. This finding made it possible to detect contaminated animals and animal products by dosage of the PCBs, more specifically by the 7 congeners with numbers 28, 52, 101, 118, 138, 153 and 180. The advantages of the dosage of PCBs compared to dioxins were its rapid test protocol and the fact that a larger number of laboratories could participate. In the cattle sector, 409 herds (0,81 p. cent) were submitted to the risk of feed contamination. The methodology used to detect a PCBs/dioxins contamination in the Belgian cattle population that was not submitted to the risk, is presented. This population is directly or indirectly destined for human consumption. It consisted in the systematic sampling of all calve fattening stations and all lots of exported bovines, and in the random sampling of slaughter cattle. This methodology is compared to the approach described in directive 96/23/CE. [less ▲]

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See detailLes spatiocartes en composition colorée
Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailLa pseudogestation chez la chèvre, facteur d'infertilité
Zarrouk, Anissa; Drion, Pierre ULg; Beckers, Jean-François ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailPeut-on aider Rosetta sans assassiner Mozart ?
Crahay, Marcel ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 196-199

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See detailLes affections du système urinaire du chat : II. Maladies du tractus urinaire inférieur : aspects diététiques
Jeusette, I.; Tonglet, C.; Istasse, Louis ULg et al

in Annales de Médecine Vétérinaire (2000), 144

This synthesis aims to summarize the specific dietary requirements for prevention or nutritional treatment of feline lower urinary tract diseases and overall urolith's formation. Since aetiologies are ... [more ▼]

This synthesis aims to summarize the specific dietary requirements for prevention or nutritional treatment of feline lower urinary tract diseases and overall urolith's formation. Since aetiologies are diverse and the epidemiological knowledge are changing within the recent year, empirical treatment of the pathology isn't anymore advisable. Symptomatology and aetiology are briefly presented and the different dietary factors to be taken into consideration in urolith's formation are discussed. Chemical composition of petfoods to treat or prevent struvite or calcium oxalate uroliths are compared [less ▲]

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See detailReduced Sperm Counts In Guppies (Poecilia Reticulata) Following Exposure To Low Levels Of Tributyltin And Bisphenol A
Haubruge, Eric ULg; Petit, François ULg; Gage, Mjg.

in Proceedings of the Royal Society B-Biological Sciences (2000), 267(1459),

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See detailSystèmes d’information géographique répartis ou distribués
Donnay, Jean-Paul ULg

in AM/FM-GIS BELUX News (2000), 17

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See detailQuoi de neuf dans le domaine de l'obesite?
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(7), 756-9

We will briefly comment on some interesting topics presented at the 10th European Congress on Obesity (ECO, Antwerp, Belgium, 24-27 May 2000). Special attention has been focused upon: 1) the multi ... [more ▼]

We will briefly comment on some interesting topics presented at the 10th European Congress on Obesity (ECO, Antwerp, Belgium, 24-27 May 2000). Special attention has been focused upon: 1) the multi-endocrine function of the adipocyte cell; 2) the role of gene-environment interactions; 3) the regulatory mechanisms of energy balance; 4) the neuroendocrine hypothesis for the development of visceral adiposity; 5) the numerous complications associated with obesity, more particularly type 2 diabetes; and, finally, 6) obesity prevention, especially in childhood, and new pharmacological perspectives for the treatment of obesity. [less ▲]

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See detailSeparation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.
Fillet, Marianne ULg; Bechet, Isabelle; Fotsing, Lucas ULg et al

in Biomedical Chromatography : BMC (2000), 14(1), 12-3

Separation of non-steroidal anti-inflammatory drugs by capillary electrophoresis using non-aqueous electrolyte.

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See detailQui gagnera la bataille des triptans ?
Schoenen, Jean ULg

in Médi Sphère (2000), (Fév/Mars), 17-18

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See detailSpectroscopic properties of protochlorophyllide analyzed in situ in the course of etiolation and in illuminated leaves
Schoefs, B.; Bertrand, M.; Franck, Fabrice ULg

in Photochemistry & Photobiology (2000), 72(1), 85-93

The spectroscopic properties of photoactive (ie. flash-transformable) and nonphotoactive protochlorophyll(ide)s (Pchl(ide)) were reinvestigated during the development of bean leaves in darkness. Two ... [more ▼]

The spectroscopic properties of photoactive (ie. flash-transformable) and nonphotoactive protochlorophyll(ide)s (Pchl(ide)) were reinvestigated during the development of bean leaves in darkness. Two phases in the process of Pchl(ide) accumulation were apparent from quantitative measurements of pigment content: a lag phase (first week) during which photoactive Pchl(ide) accumulated faster than nonphotoactive Pchl(ide); and a fast phase (second week), showing parallel accumulation of both types of Pchl(ide). 'Flashed-minus-dark' absorbance difference spectra recorded in situ at 77 K showed that P650-655 was the predominant form of photoactive protochlorophyllide regardless of developmental stage. Quantitative analysis of energy migration processes between the Pchl(ide) forms showed the existence of energy transfer units containing a 1:8 ratio of nonphotoactive and photoactive Pchl(ide)s during development. Gaussian deconvolution of in situ 77 K fluorescence spectra indicated that the 633 nm band of nonphotoactive Pchl(ide) was made of four bands, at 625, 631, 637 and 643 nm, whose relative amplitudes only slightly changed during development. The emission band of photoactive Pchlide was also analyzed using the same method. Three components were found at 644, 652 and 657 nm, The emission band of P650-655 included the last two components, which become predominant only in fully etiolated plants. Photoactive Pchlide with an emission maximum at 653 nm was detected in the light during development of leaves of photoperiodically grown plants. [less ▲]

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See detailNeospora caninum, un nouvel agent abortif chez les bovins
Losson, Bertrand ULg; Bourdoiseau, G.

in Bulletin des Groupements Techniques Vétérinaires (2000), 7

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See detailThe Three Gorges Dam on the Yangtze river
Lejeune, André ULg; Pirotton, Michel ULg

in Revue Géoglobe, "Mega-Projects" (2000), (10), 20-23

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See detailMujinga ou la soumission inconsciente à l’idéologie régnante
Vanhaegendoren, Koen ULg

in Congo-Meuse. Revue des lettres belges et congolaises de langue française (2000), 4-5

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See detailLe rôle des voies ferrées dans la mise en place des reptiles en Belgique et dans quelques terroitoires adjacents (Nord et Nord-Est de la France, Grand-Duché de Luxembourg)
Graitson, Eric ULg; Hussin, José; Parent, Georges Henri

in Naturalistes Belges (Les) (2000), 81(4), 376-395

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See detailTechnique for a rapid and efficient purification of the SHV-1 and PSE-2 beta-lactamases.
Bouillenne, Fabrice ULg; Matagne, André ULg; Joris, Bernard ULg et al

in Journal of Chromatography. B : Biomedical Sciences and Applications (2000), 737(1-2), 261-5

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ... [more ▼]

A simple procedure is described which results in an optimised resolution in molecular sieve chromatography. A sample exhibiting a large initial volume (about 20 ml) and conditioned in a buffer of low ionic strength (<20 mM) by filtration through a 53-ml G25 molecular sieve column, is adsorbed on a 1.7-ml ion-exchange (SOURCE) column. The proteins are released by a 10-ml pulse of 1 M NaCl and the eluate directly injected onto a 120-ml Sephacryl S100-HR column. The very low volume of the eluate ensures optimal conditions and resolution for the molecular sieving process. The method is applied as the polishing step in the purification of the SHV-1 and PSE-2 beta-lactamases. It could easily be scaled up for the treatment of larger samples. [less ▲]

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See detailL'évaluation externe en lecture menée à l'entrée en 3e secondaire : morceaux choisis
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (1-2), 7-11

En octobre 1998, une évaluation externe en lecture s'est déroulée dans un échantillon représentatif de classes de 3e année de l'enseignement secondaire en Communauté française de Belgique. A cette ... [more ▼]

En octobre 1998, une évaluation externe en lecture s'est déroulée dans un échantillon représentatif de classes de 3e année de l'enseignement secondaire en Communauté française de Belgique. A cette occasion, on a non seulement évalué dans quelle mesure les élèves maîtrisent certaines des compétences essentielles reprises dans les socles, mais aussi tenté de comprendre les rapports complexes que les adolescents entretiennent avec le monde de l'écrit. [less ▲]

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See detailDiscordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo.
Twizere, Jean-Claude ULg; Kerkhofs, Pierre; Burny, Arsène et al

in Journal of Virology (2000), 74(21), 9895-902

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second ... [more ▼]

Bovine leukemia virus (BLV) Tax protein, a transcriptional activator of viral expression, is essential for viral replication in vivo. Tax is believed to be involved in leukemogenesis because of its second function, immortalization of primary cells in vitro. These activities of Tax can be dissociated on the basis of point mutations within specific regions of the protein. For example, mutation of the phosphorylation sites at serines 106 and 293 abrogates immortalization potential in vitro but maintains transcriptional activity. This type of mutant is thus particularly useful for unraveling the role of Tax immortalization activity during leukemogenesis independently of viral replication. In this report, we describe the biological properties of BLV recombinant proviruses mutated in the Tax phosphorylation sites (BLVTax106+293). Titration of the proviral loads by semiquantitative PCR revealed that the BLV mutants propagated at wild-type levels in vivo. Furthermore, two animals (sheep 480 and 296) infected with BLVTax106+293 developed leukemia or lymphosarcoma after 16 and 36 months, respectively. These periods of time are within the normal range of latencies preceding the onset of pathogenesis induced by wild-type viruses. The phenotype of the mutant-infected cells was characteristic of a B lymphocyte (immunoglobulin M positive) expressing CD11b and CD5 (except at the final stage for the latter marker), a pattern that is typical of wild-type virus-infected target cells. Interestingly, the transformed B lymphocytes from sheep 480 also coexpressed the CD8 marker, a phenotype rarely observed in tumor biopsies from chronic lymphocytic leukemia patients. Finally, direct sequencing of the tax gene demonstrated that the leukemic cells did not harbor revertant proviruses. We conclude that viruses expressing a Tax mutant unable to transform primary cells in culture are still pathogenic in the sheep animal model. Our data thus provide a clear example of the discordant conclusions that can be drawn from in vitro immortalization assays and in vivo experiments. These observations could be of interest for other systems, such as the related human T-cell leukemia virus type 1, which currently lack animal models allowing the study of the leukemogenic process. [less ▲]

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See detailFirst experimental evidence of alluaudite-like phosphates with high Li-content: the (Na1-xLix)MnFe2(PO4)3 series (x = 0 to 1).
Hatert, Frédéric ULg; Keller, Paul; Lissner, Falk et al

in European Journal of Mineralogy (2000), 12

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See detailStructure et fonctionnement de la mémoire : une approche neuropsychologique
Marczewski, Philippe; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Confrontations Psychiatriques (2000), 41

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The ... [more ▼]

Memory in not a unified system. It's composed of independant but interacting systems. Cognitive neuropsychology showed dissociations between these systems in patients with various brain lesions. The episodic memory system is devoted to the processing of personally lieved events. The predominant role played by frontal regions in underlying episodic memory has been fully documented. Moreover, the episodic memory disfunctions may lead to illusions of memory such as false memories, confabulations or hallucinations. [less ▲]

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See detailAntiobesity pharmacotherapy in the management of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes/Metabolism Research & Reviews (2000), 16(2), 114-24

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction ... [more ▼]

Obesity is a well-known risk factor for the development of Type 2 diabetes mellitus. The management of the obese diabetic patient remains a challenge for the clinician but, in any case, weight reduction should be considered as a key objective. In this respect, several antiobesity drugs have demonstrated potential. However, while fenfluramine and dexfenfluramine have been shown to promote weight loss and to directly improve insulin sensitivity, being two mechanisms contributing to better blood glucose control in obese Type 2 diabetic patients, they were recently withdrawn due to safety problems. Sibutramine, a new selective norepinephrine and serotonin reuptake inhibitor, promotes weight loss by decreasing food intake, an effect which leads to a mild improvement (significant in patients losing > or =5% of initial body weight) of blood glucose control in obese diabetic patients. Similarly, orlistat, a selective gastrointestinal lipase inhibitor which increases faecal fat losses, enhances diet-induced weight reduction and improves both blood glucose control and vascular risk profile, especially dyslipidaemia, in obese Type 2 diabetic patients. Further studies are required to better identify good responders to pharmacotherapy and specify the role of antiobesity agents in the overall long-term management of obese subjects with Type 2 diabetes. Other novel pharmacological approaches deserve further consideration, for instance beta-3 agonists aiming to increase energy expenditure, drugs interfering with tumor necrosis factor-alpha (TNF-alpha) or free fatty acid release by the adipose tissue or agents that slow gastric emptying. However, until now, results regarding efficacy and/or safety have been disappointing or preliminary in humans. [less ▲]

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See detailOral contraception and cardiovascular risk factors during adolescence
Paulus, Dominique; Saint-Remy, Annie ULg; JeanJean, Michel

in Contraception (2000)

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study ... [more ▼]

The objective of the present study was to analyze the pattern of oral contraceptive (OC) use in teenagers and to examine the relationship between OC use and other cardiovascular risk factors. The study was conducted in 24 Belgian secondary schools. Most students (1526 adolecents aged 12-17 years) agreed to participate (participation rate: 83.6%). Smoking, physical activity habits, menarche, and OC use were assessed by a self-administered questionnaire. Total cholesterol level, blood pressure and anthropometric measurements were also measured. Fourteen per cent of mature girls (14%, n=92) were OC users. Two-thirds of them (66.3%, n=61) were taking OC which contained either gestodene or desogestrel. Blood pressure and BMI were similar for OC users and non-users. Total cholesterol level was significantly higher in OC users than in non-users (191 mg/dL versus 172 mg/dL). Logistic regression model confirmed the significant influence of OC use on total cholesterol level (OR=3.08). OC users were also often smokers (39% versus 20% for non-users). In conclusion, the present study has found significant relationship between OC use and cardiovascular risk factors i.e., high total cholesterol and smoking. The first implication is a need for further research on lipoprotein profile in young OC users. Secondly, the combined use of OC and smoking in teenagers calls for preventive actions. [less ▲]

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See detailEpidemiologie, physiopathologie et traitement d'une affection frequente: tinea pedis.
Lambert, Jean-Luc ULg; Richert, Bertrand ULg; Dezfoulian, Bita ULg et al

in Revue Médicale de Liège (2000), 55(3), 161-8

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly ... [more ▼]

Tinea pedis is an infection of the stratum corneum caused by dermatophytes. Nowadays, fitness centers, saunas, subtropical swimming pools and sport-shoes are more and more fashionable and are certainly responsible for the increase of cases of tinea pedis as dermatophytes grow preferentially in warm and humid environments. The clinical aspect is affected by several factors such as the host reaction to the infection, the virulence of the infective strain, species, and some local and environmental factors. If a dermatophytosis is suspected, it is mandatory to validate the provisional diagnosis by demonstration of the fungus (by culture or/and microscopic examination) to avoid useless and expensive treatments. The new antifungal molecules are very effective, well tolerated and allow short course of therapy improving the compliance of the patient in clinical practice. Relapse of tinea pedis is very common but could be avoided by several simple preventive measures of hygiene. [less ▲]

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See detailSimplification of boolean verification conditions
Gribomont, Pascal ULg

in Theoretical Computer Science (2000), 239(1), 165-185

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See detailChronique semestrielle de droit communautaire
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux (2000)

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See detailDynamics of total lipids and fatty acids during embryogenesis and larval developpement of Eurasian perch (Perca fluviatlis)
Abi-Ayad, Amine; Kestemont, P.; Mélard, Charles ULg

in Fish Physiology and Biochemistry (2000), 23

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See detailThe Bureaucracy of Crime : J. G. Ballard’s Cocaine Nights and the Speculative Thriller
Delville, Michel ULg

in Analele Universităţii Oradea - Seria Filologie, Fascicola Limba şi literatura (2000), 8

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See detailSuccessful mobilization of peripheral blood HPCs with G-CSF alone in patients failing to achieve sufficient numbers of CD34+ cells and/or CFU-GM with chemotherapy and G-CSF.
Fraipont, V.; Sautois, Brieuc ULg; Baudoux, Etienne ULg et al

in Transfusion (2000), 40(3), 339-47

BACKGROUND: Mobilization with chemotherapy and G-CSF may result in poor peripheral blood HPC collection, yielding <2 x 10(6) CD34+ cells per kg or <10 x 10(4) CFU-GM per kg in leukapheresis procedures ... [more ▼]

BACKGROUND: Mobilization with chemotherapy and G-CSF may result in poor peripheral blood HPC collection, yielding <2 x 10(6) CD34+ cells per kg or <10 x 10(4) CFU-GM per kg in leukapheresis procedures. The best mobilization strategy for oncology patients remains unclear. STUDY DESIGN AND METHODS: In 27 patients who met either the CD34 (n = 3) or CFU-GM (n = 2) criteria or both (n = 22), the results obtained with two successive strategies-that is, chemotherapy and G-CSF at 10 microg per kg (Group 1, n = 7) and G-CSF at 10 microg per kg alone (Group 2, n = 20) used for a second mobilization course-were retrospectively analyzed. The patients had non-Hodgkin's lymphoma (5), Hodgkin's disease (3), multiple myeloma (5), chronic myeloid leukemia (1), acute myeloid leukemia (1), breast cancer (6), or other solid tumors (6). Previous therapy consisted of 10 (1-31) cycles of chemotherapy with additional chlorambucil (n = 3), interferon (n = 3), and radiotherapy (n = 7). RESULTS: The second collection was undertaken a median of 35 days after the first one. In Group 1, the results of the two mobilizations were identical. In Group 2, the number of CD34+ cells per kg per apheresis (0.17 [0.02-0.45] vs. 0.44 [0.11-0.45], p = 0. 00002), as well as the number of CFU-GM (0.88 [0.00-13.37] vs. 4.19 [0.96-21.61], p = 0.00003), BFU-E (0.83 [0.00-12.72] vs. 8.81 [1. 38-32.51], p = 0.00001), and CFU-MIX (0.10 [0.00-1.70] vs. 0.56 [0. 00-2.64], p = 0.001134) were significantly higher in the second peripheral blood HPC collection. However, yields per apheresis during the second collection did not significantly differ in the two groups. Six patients in Group 1 and 18 in Group 2 underwent transplantation, and all but one achieved engraftment, with a median of 15 versus 12 days to 1,000 neutrophils (NS), 22 versus 16 days to 1 percent reticulocytes (NS), and 26 versus 26 days to 20,000 platelets (NS), respectively. However, platelet engraftment was particularly delayed in many patients. CONCLUSION: G-CSF at 10 microg per kg alone may constitute a valid alternative to chemotherapy and G-CSF to obtain adequate numbers of peripheral blood HPCs in patients who previously failed to achieve mobilization with chemotherapy and G-CSF. This strategy should be tested in prospective randomized trials. [less ▲]

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See detailInfo-congres. Recherche en diabetologie: rayonnement europeen de l'Ecole de Liege.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(10), 960-7

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See detailInhibiting Effect of Ammonia on Citric Acid-Induced Cough in Pigs: A Possible Involvement of Substance P
Moreaux, B.; Nemmar, A.; Beerens, Dominique ULg et al

in Pharmacology & Toxicology (2000), 87(6), 279-285

The effect of ammonia on the cough response to citric acid and on substance P release from C-fibers involved in this reflex was assessed. For a period from one to four days, piglets were exposed, in an ... [more ▼]

The effect of ammonia on the cough response to citric acid and on substance P release from C-fibers involved in this reflex was assessed. For a period from one to four days, piglets were exposed, in an inhalation chamber, to ammonia at a concentration of 15 or 30 ppm. During exposure, cough induction tests were done every two days. Recovery of the cough reflex after ammonia exposure was also determined. In a separate group of piglets exposed for 2 days to 30 ppm ammonia, substance P content was determined in bronchial and tracheal lavage fluids and in the tracheal and bronchial mucosa. Ammonia (30 ppm) was found to inhibit coughing significantly (the cough frequency was reduced by 64%) after a two-day exposure. In animals exposed for 4 days to this ammonia concentration, the recovery ranged from 3 to 7 days (mean: 5 days). The same ammonia concentration also caused the substance P content to increase significantly in bronchoalveolar lavage fluid (to 432% of its initial value) and tracheal lavage fluid (to 149%) and to decrease significantly in the tracheal mucosa (-58%), however the content in bronchial mucosa was not significantly affected (-43%). Exposure to 15 ppm ammonia had no effect on the frequency of citric acid-induced coughing. In conclusion, ammonia inhibits citric acid-induced coughing in pigs at concentrations that can be detected in piggeries. This inhibitory effect may be related to substance-P depletion in C-fiber endings [less ▲]

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See detailNature et qualités de spatiocartes
Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38

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See detailL'etude clinique du mois. L'apres DCCT, l'etude EDIC.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(3), 187-9

The "Diabetes Control and Complications Trial" (DCCT) demonstrated that intensive insulin therapy, by reducing HbA1c levels by about 2%, delays the onset and slows the progression of microangiopathic ... [more ▼]

The "Diabetes Control and Complications Trial" (DCCT) demonstrated that intensive insulin therapy, by reducing HbA1c levels by about 2%, delays the onset and slows the progression of microangiopathic complications (by at least 50%) in patients with type 1 diabetes. The "Epidemiology of Diabetes Interventions and Complications" (EDIC) study recently showed that the reduction in the risk of progressive retinopathy and nephropathy resulting from intensive therapy during the DCCT not only persists, but is amplified for at least 4 years (reduction by about 80% when compared to diabetic patients previously treated with conventional therapy during the DCCT). [less ▲]

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See detailEcoliers et apprentis-lecteurs : quelle est la motivation des enfants en première primaire ?
Hindryckx, Geneviève ULg; Lafontaine, Annette ULg; Schockert, C.

in Point sur la Recherche en Education (Le) (2000)

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See detailSucceeded plant regeneration from very immature embryos of Phaseolus vulgaris
Geerts, P.; Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (2000), (43), 206-207

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See detailDeletion Analogues Of Transportan
Soomets, U.; Lindgren, M.; Gallet, X. et al

in Biochimica et Biophysica Acta-Biomembranes (2000), 1467(1), 165-76

Several shorter analogues of the cell penetrating peptide, transportan, have been synthesized in order to define the regions of the sequence, which are responsible for the membrane translocation property ... [more ▼]

Several shorter analogues of the cell penetrating peptide, transportan, have been synthesized in order to define the regions of the sequence, which are responsible for the membrane translocation property of the peptide. Penetration of the peptides into Bowes melanoma cells and the influence on GTPase activity in Rin m5F cellular membranes have been tested. The experimental data on cell penetration have been compared with molecular modeling of insertion of peptides into biological membranes. Omission of six amino acids from the N-terminus did not significantly impair the cell penetration of the peptide while deletions at the C-terminus or in the middle of the transportan sequence decreased or abolished the cellular uptake. Most transportan analogues exert an inhibitory effect on GTPase activity. Molecular modeling shows that insertion of the transportan analogues into the membrane differs for different peptides. Probably the length of the peptide as well as the location of aromatic and positively charged residues have major impact on the orientation of peptides in the membranes and thereby influence the cellular penetration. In summary, we have designed and characterized several novel short transportan analogues with similar cellular translocation properties to the parent peptide, but with reduced undesired cellular activity. [less ▲]

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See detailDe la medecine factuelle aux recommandations therapeutiques. Epilogue.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (2000), 55(5), 476-7

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See detailHigh Resolution Electron Energy Loss Spectroscopy Investigation of the Vibrational Structure and Order of an Octadecanethiol Monolayer on Gold Substrates
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Journal of Physical Chemistry B (2000), 104

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the ... [more ▼]

The vibrational spectra induced by electron beam from octadecanethiol monolayers adsorbed on gold are reported as a contribution to study in detail the structure of the layers, through an analysis of the interaction mechanisms between the electrons and these organic ultrathin films. To show the different spatial distribution of scattered electrons from dipole and impact interactions with the monolayer, angular distributions of elastic and inelastic scattered electrons were measured for various primary energies. The absolute electron scattering loss probabilities from both dipole and impact interactions were estimated for different vibrational modes. The study of these different mechanisms was first hampered by the poor order of the layers adsorbed on evaporated gold. It became therefore highly desirable to perform the experiments on a single-crystal substrate. Using Au(111) and Au(100) single crystals as substrates, it was possible to separate the spectral response from impact and dipole interacting electrons. A negative ion resonant behavior has been observed in the energy dependence of the electron scattering differential cross sections [less ▲]

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See detailLe dosage des auto-anticorps anti-GAD et anti-IA 2: une aide au diagnostic precoce du diabete de type 1.
Luyckx, Françoise ULg; Delcourt, Sandrine ULg; Philips, Jean-Christophe ULg et al

in Revue Médicale de Liège (2000), 55(3), 169-75

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal ... [more ▼]

Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal management. In that slowly progressive disease leading to severe and irreversible complications, the use of early and specific genetic, immunological and/or metabolic markers may help in the classification of diabetic patients and in the orientation of therapeutic strategies; furthermore, it is also an essential aid in the early screening of subjects at risk of developing the disease. The assessment of classical immunological markers, such as islet cell antibodies (ICA) or anti-insulin antibodies (IAA) has been recently completed by the screening of new promising markers such as GAD- and IA2-antibodies. The presence of these markers confirms the autoimmune component of the disease and thus supports the diagnosis of type 1 diabetes, even if clinical symptoms are absent or inconsistent. In addition, it represents a strong argument in favour of the initiation of specific immunological therapies to preserve B-cell number and function. [less ▲]

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See detailGeochemistry of granitoids from the south Carpathians: A review
Berza, Tudor; Andar, Petre; Tatu, Mihai et al

in Anuarul Institutului Geologic al României (2000), 71

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See detailSynthesis of 2-aminoquinazoline-4(3H)-one derivatives as potential potassium channel openers
Erb, B.; Akue, R.; Rigo, B. et al

in Journal of Heterocyclic Chemistry (2000), 37

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See detailVolume tables for small trees of larch (Larix sp.) in the southern part of Belgium
Rondeux, Jacques ULg; Pauwels, D.

in Forestry (2000), 73(1), 91-93

Volume tables have been constructed for European larch (Larix decidua Mill.), Japanese larch (Larix kaempferi (Lamb.) Carr.) and hybrid larch (Larix X eurolepis Henry) trees in the Ardenne (southern part ... [more ▼]

Volume tables have been constructed for European larch (Larix decidua Mill.), Japanese larch (Larix kaempferi (Lamb.) Carr.) and hybrid larch (Larix X eurolepis Henry) trees in the Ardenne (southern part of Belgium), which is a natural region located at elevations ranging from 340 to 550 m on mainly siliceous rocks. The application of the proposed tables is only for trees whose diameters (d.b.h.) are less than 22 cm over bark at 1.3 m above ground level. They are particularly useful for estimating total tree volume of trees (excluding branches) of early thinnings and volume increment of small-sized trees in genetic improvement experiments. The volume equations are based on data collected over a wide range of site conditions. In these regional volume tables, the volumes (total volume of the stem and volume to an upper diameter limit of 7 cm) are correlated with both d.b.h. and total height. [less ▲]

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See detailLa maladie du hêtre : catastrophe écologique ou accident de la nature.
Rondeux, Jacques ULg

in Parcs & Réserves (2000), 55(3-4), 49

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See detailSystemic Induction Of Phytoalexins In Cucumber In Response To Treatments With Fluorescent Pseudomonads
Ongena, MARC ULg; Daayf, F.; Jacques, Philippe ULg et al

in Plant Pathology (2000), 49(4),

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of ... [more ▼]

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of antifungal phenolics in the treated roots. In this study, analyses of root extracts from split-root experiments showed that these phytoalexins were produced systemically. Indeed, several antifungal molecules accumulated similarly in both treated and nontreated root parts of plants protected against P. aphanidermatum with BTP1 or M3. In addition, analyses of leaf samples also revealed increased amounts of fungitoxic molecules in PGPR-treated plants, although the nature of these molecules appeared to be different from those detected in roots. The antifungal compounds isolated both from roots and leaves were mainly detected in acid-hydrolyzed extracts containing aglycones. These results suggest that PGPR can elicit phytoalexins systemically in cucumber and that the overall defence response is not based on a single phytoalexin but is chemically complex and organ-specific. [less ▲]

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See detailActualites therapeutiques 2000.
Scheen, André ULg

in Revue Médicale de Liège (2000), 55(9), 852-61

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The originality of each molecule as well as its modalities of appropriate use in clinical practice will be emphasized. [less ▲]

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See detailEvolution des connaissances sur la membrane du globule gras du lait: synthese bibliographique.
Danthine, Sabine ULg; Blecker, Christophe ULg; Paquot, Michel ULg et al

in Lait (2000), 80(2), 209-222

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat ... [more ▼]

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat in the milk plasma. This protective coat is generally called 'the milk fat globule membrane' (MFGM). This review examines the present state of knowledge on the MFGM. The topics dealt with are: origin and formation, isolation From milk, composition (lipids and proteins), structure (a new model is proposed), functional properties and the role that the MFGM plays in protection against lipolysis. [less ▲]

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See detailFeed restriction in young bulls alters the onset of puberty in relationship with plasma insulin-like growth factor-I (IGF-I) and IGF-binding proteins.
Renaville, Robert ULg; Van Eenaeme, Christian ULg; Breier, B. H. et al

in Domestic Animal Endocrinology (2000), 18(2), 165-76

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA ... [more ▼]

The objectives of this study were to evaluate the effect of feed restriction and re-alimentation on the onset of puberty and IGF status in peripubertal male calves and to compare the radioimmunoassay (RIA) and western ligand blotting (WLB) methods for bovine IGFBP-2. Twelve prepubertal 290 d-old Belgian Blue bulls (mean weight: +/- 290 kg) were randomly assigned in three groups: a control group (NG; n = 4) receiving a classic fattening diet to induce "normal" growth (1.48 kg/d), a feed restricted group (RG; n = 4) to obtain reduced growth (0.50 kg/d) and, a severely restricted group (SG; n = 4) to nearly stop growth (0.08 kg/d). The feed restriction period was maintained over a period of 114 d. After the period of differential feeding, all animals received the control feed regime over a period of 100 d. Blood samples were collected at fortnightly intervals. Circulating IGF-I was measured by RIA whereas plasma IGFBPs was evaluated by WLB; IGFBP-2 was additionally quantified by RIA procedure. At the beginning of the trial, IGF-I levels were low (<100 ng/ml) and similar in the three groups in accordance with prepubertal status. In the NG group, a progressive rise in IGF-I was observed from Day 42 to Day 142 whereas in the RG and SG groups, IGF-I levels did not change until the experimental restriction period ended. The delay of the rise in plasma IGF-I was longer for the SG group, IGF-I remained low until 2 wk after the end of the period of restricted feeding. Surprisingly, although differences were detected for IGF-I levels between the three groups, the IGFBP-2 and -3 data, evaluated by WLB could only discriminate between NG and SG group and not between NG and RG. However, by using a RIA method, an IGFBP-2 decrease was observed in the NG group coincident with increasing IGF-I levels. For both RG and SG groups, IGFBP-2 levels remained high throughout the feed restriction period whereas plasma IGFBP-2 levels declined upon feeding in both groups. During this feed restriction period, IGFBP-2 was significantly lower in NG than in RG or SG groups. Moreover, SG group animals had higher levels in plasma IGFBP-2 than RG animals. In conclusion, puberty is characterized by developmental changes in plasma IGF-I and IGFBPs that were altered by feed restriction. Moreover, RIA evaluation of plasma IGFBP-2 is able to better reflect group differences than WLB. [less ▲]

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See detailLe mélèze, une essence à haut potentiel de production
Pauwels, Dominique; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(3), 6-10

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze ... [more ▼]

Dans un précédent article "le mélèze, un atout dans les objectifs de diversification de notre sylviculture" (PAUWELS et RONDEUX, 2000), nous nous sommes efforcés de montrer que la culture du mélèze méritait, à plusieurs égards, d'être davantage prise en compte en Région wallonne et ce, pour autant qu'une sylviculture adaptée à l'essence et aux conditions du milieu soit appliquée. Les lignes qui suivent sont consacrées à des résultats originaux résultant d'une étude menée par l'Unité de Gestion et Economie forestières de la Faculté universitaire des Sciences agronomiques de Gembloux, sur la croissance des mélèzes en Région wallonne. Le potentiel de croissance du mélèze a été évalué à partir d'analyses de tiges ou de mesures réalisées au sein de placettes de production (figure 1) remesurées tous les 3 ans. A partir d'une exploitation appropriée de ces données, on a déduit une gamme de traitements sylvicoles capables de rencontrer les objectifs de production que l'essence permet d'atteindre. [less ▲]

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See detailEvidence For Specific And Non-Covalent Binding Of Lipids To Natural And Recombinant Mycobacterium Bovis Bcg Hsp60 Proteins, And To The Escherichia Coli Homologue Groel
De Bruyn, J.; Soetaert, K.; Buyssens, P. et al

in Microbiology-Sgm (2000), 146

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 ... [more ▼]

Heat-shock proteins (Hsps) from various origins are known to share a conserved structure and are assumed to be key partners in the biogenesis of proteins. Fractionation of the mycobacterial Hsp60, a 65 kDa protein also called Cpn60, from Mycobacterium bovis BCG zinc-deficient culture filtrate on phenyl-Sepharose followed by Western blotting revealed the existence of four Hsp60-1 and Hsp60-2 forms, based on their hydrophobicity behaviour. Hsp60-2 species were further purified by ion-exchange chromatography and partial amino acid sequences of cyanogen bromide (CNBr) peptides of purified Hsp60-2 species showed identity with the amino acid sequence deduced from the hsp60-2 gene, indicating that the various Hsp60-2 forms are encoded by the same gene. In addition, the mycobacterial Hsp60-2 was overexpressed in E. coli using the pRR3Hsp60-2 plasmid and analysed on phenyl-Sepharose. The elution pattern of the recombinant Hsp60-2, as well as that of Escherichia coli GroEL, was similar to that of the native Hsp60-2 from the culture filtrate of M. bovis BCG and entirely different from that of the mycobacterial antigen 85. Extraction of mycobacterial Hsp60-2 forms, recombinant BCG Hsp60-2 and E. coli GroEL with organic solvents releases various amounts of non-covalently bound lipids. The presence of lipids on Hsp60-2 was confirmed by labelling M. bovis BCG with radioactive palmitate. The radioactivity was specifically associated with Hsp60 in the aqueous phase and the 19 and 38 kDa lipoproteins in the Triton X-114 phase. Analysis of the lipids extracted from purified Hsp60-2, recombinant BCG Hsp60-2 and E. coli GroEL by TLC showed the same pattern for all the samples. Acid methanolysis of the lipids followed by GC analysis led to the identification of C(16:0), C(18:0) and C(18:1) as the major fatty acyl constituents, and of methylglycoside in these proteins. Altogether, these data demonstrate that lipids are non-covalently bound to Hsp60-2 and homologous proteins. [less ▲]

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See detailEpidemiologische bewaking van boviene spongiforme encefalopathie in Belgïe: Jaaroverzicht voor 1998
Saegerman, Claude ULg; Dechamps, P.; Vanopdenbosch, E. et al

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

In 1998 werden 6 runderen tussen de 54 en 71 maanden ouderdom, afkomstig van de provincies West-Vlaanderen (3 gevallen), Oost-Vlaanderen (2 gevallen) en Luik (1 geval), gediagnostiseerd als gevallen van ... [more ▼]

In 1998 werden 6 runderen tussen de 54 en 71 maanden ouderdom, afkomstig van de provincies West-Vlaanderen (3 gevallen), Oost-Vlaanderen (2 gevallen) en Luik (1 geval), gediagnostiseerd als gevallen van boviene spongiforme encephalopathie (BSE). De hypotheses betreffende de oorsprong van de infectie op zijn de volgende : het optreden van sporadische gevallen zonder duidelijk definieerbare oorzaak; de mogelijke kruiscontaminatie tussen voeder voor monogastrische dieren met daarin dierlijk meel en voeder voor herkauwers waarin geen dierlijk meel is verwerkt en dit tijdens het fabricatieproces, de stockage, het transport of de distributie; het gebruik van dierlijk beendermeel in het voeder voor runderen geproduceerd voor de ban (van kracht vanaf 27/7/1994). Algemeen kan men dus stellen dat in België de aanwezigheid van gecontamineerd diermeel als risicofactor voor BSE niet kan worden uitgesloten. De oorsprong van deze diermelen kon nog niet gedetermineerd worden. [less ▲]

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See detailMass-murder deletion of 19 Orfs from Saccharomyces cerevisiae chromosome XI
Vandenbol, Micheline ULg; Fairhead, C.

in Gene (2000), 247(1-2),

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See detailAnnotations to the Devonian Correlation Table, B50di00: Miospore Palynology, Western Europe
Steemans, Philippe ULg

in Senckenbergiana lethaea (2000), 80(2), 759-760

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See detailUn outil d’optimisation des structures orthotropes intégré à l’avant-projet
Rigo, Philippe ULg

in Construction Métallique (2000)

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See detailProtective Effects Of A Live Attenuated Bovine Leukaemia Virus Vaccine With Deletion In The R3 And G4 Genes
Reichert, M.; Cantor, Gh.; Willems, Luc ULg et al

in Journal of General Virology (2000), 81

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See detailSimulated And Measured Coefficients Of Variation For The Spray Distribution Under A Static Spray Boom
Debouche, Charles ULg; Huyghebaert, B.; Mostade, O.

in Journal of Agricultural Engineering Research (2000), 76(4), 381-388

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with ... [more ▼]

The spray pattern characteristics of a number of different series of flat fan nozzles were investigated in two ways. The first method was to measure the distribution by means of a classic patternator with collecting cylinders. The second method consisted of numerical simulation of the distribution, by combining the real distributions of a number of nozzles. The real distribution was measured on a classic patternator for each nozzle separately. The numerical simulation is computerized and automated. This system allows both time and labour gains, and permits multiple trials with the same series of nozzles. Numerical simulation results are compared with spray distributions obtained on the patternator. The sprayed volumes of liquid were found to be significantly different from the simulated ones (level of significance 95%). However, the coefficient of variation characterizing the homogeneity of the spread volumes can be calculated using simulated volumes. This can be done once an empirical linear relation is established between the coefficients of variation obtained from simulated volumes and the ones obtained from measured volumes. [less ▲]

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See detailCompte-rendu de l'ouvrage de Claudine Poulouin : Le temps des origines
Donneau, Olivier ULg

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2000), 4

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See detailDescriptio Urbis Romae
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (2000)

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See detailGeneral report - Session on connections
Jaspart, Jean-Pierre ULg

in Journal of Constructional Steel Research (2000), 55

As a result of a world-wide intensive research activity, a new design concept for structural moment resistant joints has been suggested and implemented in design codes. In the present paper, its ... [more ▼]

As a result of a world-wide intensive research activity, a new design concept for structural moment resistant joints has been suggested and implemented in design codes. In the present paper, its background is first briefly described and the main contributions to its development are presented. As a matter of fact, because of the high number of past and ongoing researches, reports and papers devoted to this topic, an exhaustive list of all these works could not be established in a limited number of pages. The possibilities of extension of the new design concepts, which have been first developed for steel beam-to-column joints under static loading, are particularly pointed out. This aspect appears quite important as in the near future it should provide designers with a unified design approach for structural joints whatever their loading, their configurations and the nature of their constitutive material(s). [less ▲]

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See detailMorphological comparison of the buccal apparatus in two bivalve commensal Teleostei : Encheliophis dubius and Onuxodon fowleri (Carapidae, Ophidiiformes)
Parmentier, Eric ULg; Castro-Aguirre, J. L.; Vandewalle, Pierre ULg

in Zoomorphology (2000), 120

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic ... [more ▼]

Onuxodon fowleri and Encheliophis dubius are two Carapidae species that live in bivalve hosts and, their diet is made of the same type of prey. The aim of this study is to compare their cephalic morphology to see whether 1) the head anatomy of both species is related to the constraints of their way of life, and 2) there are difference between these species and commensal carapids that shelter in other invertebrates. The components of their skeletons and muscles are similar, but differ in size and are arranged differently. In O. fowleri, the buccal cavity is smaller than in E. dubius, the jaws (bearing very large anterior teeth) are larger, the quadrato-mandibular joint lies further to the rear, the fibres of muscle bundles A3a, A2a and A2b are more vertical and insert higher on the neurocranium. The buccal system of O. fowleri appears better suited for ingesting food by biting and grasping. That of E. dubius seems better adapted to a feeding mechanism where sucking would have a more important role. The E. dubius head morphology is more similar to the cephalic anatomy of non-bivalve commensal species than to O. fowleri features. Diet constraints may have greater influence than the different host constraints on the head construction. A simulated backward rotation of the posterior part of the E. dubius suspensorium around the posterior joint between the hyomandibular and the neurocranium brings the jaws and the cheeks to coincide with those of O. fowleri. This model could be indicative of how structure modifications and their influences on annex pieces could in part have a role in the biodiversity. [less ▲]

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See detailFrom neurophysiology to genetics: cortical information processing in migraine underlies familial influences--a novel approach
Sandor, P. S.; Afra, J.; Proietti Cecchini, A. P. et al

in Functional Neurology (2000), 15(Suppl 3), 68-72

Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory ... [more ▼]

Migraine patients show impaired cortical information processing between attacks with deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. VEP-habituation and IDAP were studied in 40 migraine patients, i.e. pairs of 20 parents and their children. We developed a novel approach based on Monte Carlo statistics to selectively assess vertical familial influences. Both groups, parents and children, were characterized by abnormal VEP-habituation and IDAP. However, similarity between related pairs was far more pronounced than similarity between unrelated pairs. Assessed with a novel statistical approach, familial influences proved to be highly significant in determining cortical information processing in migraineurs, thus supporting the important role of genetic factors. [less ▲]

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See detailIdentification of animals treated with bovine somatotropin : a new non-isotopic detection system for bST
Baronheid, Christophe; Bertozzi, Carlo; Renaville, Robert ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4

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See detailCompte-rendu de : Kirsten Geißler, Die öffentliche Wasserversorgung im römischen Recht
Gerkens, Jean-François ULg

in Tijdschrift voor rechtsgeschiedenis (2000)

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See detailCattle neosporosis in Belgium : a case-control study in dairy and beef cattle
De Meerscham, F.; Focant, C.; Boreux, R. et al

in International Journal for Parasitology (2000)

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See detailTraitement des cephalees de tension
Schoenen, Jean ULg

in Revue Neurologique (2000), 156(Suppl 4), 487-92

The scientific basis of tension- type headache suffers from the lack of precise pathophysiological knowledge and the heterogenecity of this disorder. Treatment of acute tension-type headache episodes is ... [more ▼]

The scientific basis of tension- type headache suffers from the lack of precise pathophysiological knowledge and the heterogenecity of this disorder. Treatment of acute tension-type headache episodes is more effective with an NSAIDs (ibuprofen 400-800mg, naproxen 550-825mg, ketoprofen 50-75mg) than with aspirin or paracetamol. Caffein containing preparations of NSAIDs are slightly superior, but should not be taken frequently to avoid headache chronification. For chronic tension-type headache, relaxation therapies with EMG biofeedback and tricyclics have about the same efficacy rate of 40-50p.100. Physical therapy and acupuncture are in general less effective. There is thus clearly a need for better strategies, e.g. combination of available therapies and novel approaches. [less ▲]

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See detailLes débuts de l'humanité dans le Prométhée enchaîné d'Eschyle
Renaud, Jean-Michel ULg; Wathelet, Paul ULg

in Uranie : Mythes et Littératures (2000), 9

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See detailMission du team belge au Kosovo: science et justice à la rencontre du drame humain. Premiers résultats
BEAUTHIER, Jean-Pol; Boxho, Philippe ULg; CREVECOEUR, Jean-Marie et al

in Revue de Biométrie humaine et d'Anthropologie (2000)

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See detailPart 9: Shrinkage for service and accident conditions
Schneider, Ulrich; Schwesinger, P.; Debicki, Gérard et al

in Materials and Structures (2000), 33

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See detailLa lecture, un ouvrage féminin: Enquête sur les pratiques de lecture auprès des jeunes de14-15 ans en Communauté française de Belgique
Lafontaine, Dominique ULg; Schillings, Patricia ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2000), 47-48

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See detailIdentification et caractérisation partielle d'un gène de Fasciola hepatica d'intérêt diagnostique
Bossaert, K.; Martin-Alonzo, J. M.; Ruiz de Eguino, A. D. et al

in Annales de Médecine Vétérinaire (2000), 144

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