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See detailCoumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
Pochet, Lionel; Doucet, Caroline; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry (2000), 8(6), 1489-1501

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See detailEvidence-based medicine. Apport des etudes epidemiologiques.
REGINSTER, Jean-Yves ULg; BETZ, Romain ULg

in Revue Médicale de Liège (2000), 55(4), 211-5

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies ... [more ▼]

Epidemiological studies, more specifically those related to analytical epidemiology are a major determinant of evidence-based medicine. When classifying the value of the different epidemiological studies, based on their level of causality, cohort studies are ranked higher than case-control studies, mainly due to the fact that they allow direct collection of information on exposition to risk factors and health consequences. However, case-control studies can also provide an important information, if a specific effort is dedicated to the analyses of the circumstances of the exposition. Meta-analysis increases, by pooling them, the statistical power of individual studies of limited size. Meta-analysis can also be considered as an important source of evidence in the perspective of evidence-based medicine. [less ▲]

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See detailEffect of Temperature on Growth of Psychrophilic and Psychrotrophic Members of Rhodotorula Aurantiaca
Sabri, Ahmed ULg; Jacques, Philippe ULg; Weekers, Frederic et al

in Applied Biochemistry and Biotechnology (2000), 84-86(Spring), 391-9

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium ... [more ▼]

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium (Ardennes area). Cell production, maximum growth rate (mu max), and half-saturation constant for glucose uptake (Ks) of both yeasts were temperature dependent. For the two yeasts, a maximum cell production was observed at about 0 degree C, and cell production decreased when temperature increased. The mu max values for both strains increased with temperature up to a maximum of 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. For both yeasts, Ks for glucose was relatively constant at low temperatures. It increased at temperatures above 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. Although its glucose affinity was lower, the psychrotrophic strain grew more rapidly than the psychrophilic one. The difference in growth rate and substrate affinity was related to the origin of the strain and the adaptation strategy of R. aurantiaca to environmental conditions. [less ▲]

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See detailInternational acquisitions and shareholder wealth: evidence from the Netherlands
Corhay, Albert ULg; Tourani-Rad, Alireza

in International Review of Financial Analysis (2000), 9(2), 163-174

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See detailTectonic vs. shallow origin of geodetically inferred ground movements: an NE Ardenne (Belgium) case
Demoulin, Alain ULg; Vliegen, Bernard; Charlier, Robert ULg

in Earth and Planetary Science Letters (2000), 181(1-2), 217-228

In order to get a better insight into the temporal pattern of height change variations in a moderately seismic intraplate area, a 1 km long section has been weekly leveled from April, 21, 1997 to January ... [more ▼]

In order to get a better insight into the temporal pattern of height change variations in a moderately seismic intraplate area, a 1 km long section has been weekly leveled from April, 21, 1997 to January, 12, 1998 in NE Ardenne (Belgium). As this section is located very close to a small reservoir of 25 X 10(6) m(3), it also allowed the influence of lake level variations on the nearby ground motion to be studied. The measured height difference variations show a maximum amplitude of 3.45 mm, with weekly values not exceeding 1 mm. A two-dimensional (2D) finite element modeling confirms that waterload variations in the lake are the primary cause of movement of the section, inducing maximum ground subsidence of about 2 cm and seasonal tilting of 3-4 mu rads within a range of 2-3 km. We also show that a fault passively alters the spatial distribution of the waterload-dependent movements. The removal of this component from the observed ground motion leaves oscillating residual displacements characterized by an amplitude of 1-1.5 mm and a 'period' of about 2 months. We demonstrate that these displacements are independent of rainfall and probably of groundwater fluctuation too. Although most of the residual motions take place on the fault straddled by the leveling section, no credible mechanism can be found to ascribe these motions to a tectonic process. (C) 2000 Elsevier Science B,V. All rights reserved. [less ▲]

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See detailAssessment of postprandial hepatic glycogen synthesis from uridine diphosphoglucose kinetics in obese and lean non-diabetic subjects.
Paquot, Nicolas ULg; Schneiter, P.; Scheen, André ULg et al

in International Journal of Obesity & Related Metabolic Disorders (2000), 24(10), 1297-302

BACKGROUND: Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. Whether they also have impaired postprandial hepatic ... [more ▼]

BACKGROUND: Obese patients are frequently characterized by insulin resistance and decreased insulin-mediated glycogen synthesis in skeletal muscle. Whether they also have impaired postprandial hepatic glycogen synthesis remains unknown. AIM: To determine whether postprandial hepatic glycogen synthesis is decreased in obese patients compared to lean subjects. METHODS: Lean and obese subjects with impaired glucose tolerance were studied over 4h after ingestion of a glucose load. Hepatic uridine diphosphoglucose kinetics were assessed using 13C-galactose infusion, with monitoring of urinary acetaminophen-glucuronide isotopic enrichment to estimate hepatic glycogen kinetics. RESULTS: Estimated net hepatic glycogen synthesis amounted to 18.6 and 22.6% of the ingested load in lean and obese subjects, respectively. CONCLUSION: Postprandial hepatic glycogen metabolism is not impaired in non-diabetic obese subjects. [less ▲]

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See detailInfluence of ventilatory pattern on respiratory impedance measured by impulse oscillometry in horses
Van Erck, Emmanuelle ULg; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440(R219-R220),

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See detailComparison of a nurse-directed weight-based heparin nomogram with a standard doctor-based regimen
FRAIPONT, V; LAMBERMONT, Bernard ULg; MOONEN, M et al

in Intensive Care Medicine (2000), 26(4), 218

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See detailPhytothérapie traditionnelle des bovins dans les élevages de la plaine de la Ruzizi
Byavu, N.; Henrard, C.; Dubois, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(3), 135-156

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See detailMultimedia education in headache: the European Neurological Network.
Russell, M. B.; Dremstrup Nielsen, K.; Rasmussen, C. et al

in European Journal of Neurology (2000), 7(3), 355-62

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve ... [more ▼]

The European Neurological Network is a European Economic Community supported project. The purpose of the project was to develop a multimedia educational tool for general practitioners in order to improve their management of sleep disorders, epilepsy and headache. The project involves approximately one hundred engineers and physicians from Belgium, Denmark, England, Finland, France, Germany, Italy, Portugal and Spain. This paper concerns the multimedia educational tool on headache. The system consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. The headache classification of the International Headache Society is provided in full text as a work of reference. This classification is used world wide and has been adopted by International Classification of Diseases 10 Neurological Adaptation (ICD-10 NA) and the World Health Organisation. The clinical data concentrate on migraine and tension-type headache, the two most common headache disorders, but data on familial hemiplegic migraine, cluster headache, drug-induced headache and secondary headaches are also available. The headache tutorial consists of case records that the user can test their diagnostic abilities on. The diagnostic headache diary is an expert system on headache diagnostics. It can be filled in during a consultation in order to provide the headache diagnosis or it can be printed and used by the headache patient to record headache attacks and medicine consumption. The nomenclature module provides an explanation of words and expressions used in the system. [less ▲]

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See detailLa chondroprotection aujourd’hui
Reginster, Jean-Yves ULg; Ethgen, Olivier ULg; Dang Vu, T

in Rhumatologie (2000), 52(8), 13-16

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See detailOne session assessment of pulmonary arteries and peripheral veins by spiral CT angiography in acute pulmonary embolism
GHAYE, B; SZAPIRO, D; WILLEMS, V et al

in Resuscitation (2000), 45

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See detailCharacterization of recombinant wild type and site-directed mutations of apolipoprotein C-III: lipid binding, displacement of ApoE, and inhibition of lipoprotein lipase.
Liu, H.; Talmud, P. J.; Lins, Laurence ULg et al

in Biochemistry (2000), 39(31), 9201-12

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated ... [more ▼]

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated in lipid binding (L9T/T20L, F64A/W65A) or LPL inhibition (K21A), were compared. Relative lipid binding efficiencies to dimyristoylphosphatidylcholine (DMPC) were L9T/T20L > WT >K21A > F64A/W65A with an inverse correlation with size of the discoidal complexes formed. Physicochemical analysis (Trp fluorescence, circular dichroism, and GdnHCl denaturation) suggests that L9T/T20L forms tighter and more stable lipid complexes with phospholipids, while F64A/W65A associates less tightly. Lipid displacement properties were tested by gel-filtrating apoE:dipalmitoylphosphatidylcholine (DPPC) discoidal complexes mixed with the various apoC-III variants. All apoC-III proteins bound to the apoE:DPPC complexes; the amount of apoE displaced from the complex was dependent on the apoC-III lipid binding affinity. All apoC-III proteins inhibited LPL in the presence or absence of apoC-II, with F64A/W65A displaying the most inhibition, suggesting that apoC-III inhibition of LPL is independent of lipid binding and therefore of apoC-II displacement. Taken together. these data suggest that the hydrophobic residues F64 and W65 are crucial for the lipid binding properties of apoC-III and that redistribution of the N-terminal helix of apoC-III (L9T/T20L) enhances the stability of the lipid-bound protein, while LPL inhibition by apoC-III is likely to be due to protein:protein interactions. [less ▲]

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See detailUnimolecular reaction dynamics from kinetic energy release distributions. VI. Energy-selected ions
Lorquet, Jean-Claude ULg

in International Journal of Mass Spectrometry (2000), 201(1-3), 59-67

The kinetic energy distribution (KERD) determined by Brand et al. [Chem. Phys. 76 (1983) 111] for the iodine loss from energy-selected iodopropane ions has been analyzed by the maximum entropy method. The ... [more ▼]

The kinetic energy distribution (KERD) determined by Brand et al. [Chem. Phys. 76 (1983) 111] for the iodine loss from energy-selected iodopropane ions has been analyzed by the maximum entropy method. The entropy deficiency DS has been determined and the value of e(-DS), which measures the efficiency of phase-space sampling, has been found equal to about 96%, thus corresponding to a nearly fully statistical situation. The phase space theory of Klots describes a slightly more constrained situation with e(-DS) ≃ 77%. A rapid determination of the sampled fraction of phase space is possible from energy-selected KERDs, based on the fact that there exists a direct relationship between the efficiency e(-DS) and the reduced maximum of the KERD ε(red)/(M) = ε(M) (E)/<ε>(E). The product ε(M)(E) P(ε(M)/E) or ε(red)/(M) P(ε(red)/(M)) holds the same property. (C) 2000 Elsevier Science B.V. [less ▲]

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See detailEspaces scolaires et violence
Born, Michel ULg

in PEB Echanges (2000)

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See detailChina’s Economic Security
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2000), Vol. XVII

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See detailTraitement médical des colites aiguës inflammatoires sévères
Belaiche, Jacques ULg; Louis, Edouard ULg

in Hépato-Gastro (2000), 7

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2000), 37(2), 198203

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the ... [more ▼]

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35–76 years). According to the International Union Against Cancer (UICC) 1997 classification, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classification was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20–331 months). In a median period of 12 months (range 5–139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy ±postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% confidence interval (CI), 41–73%) and 38% (95% CI, 21–55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41–73%) and 48% (95% CI, 32–64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22–50%) and 18% (95% CI, 2–34%), respectively. In multivariate analyses, survival was significantly influenced by the N-classification, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squamous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no difference in terms of survival between patients treated by surgery and those treated by primary radiotherapy ±salvage surgery, with 39% having organ preservation. [less ▲]

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See detailChanging dynamics of the Loire river in Burgundy (France) during the last 200 years
Leteinturier, B.; Engels, Patrick ULg; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2000)

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See detailHet botkapitaal : een spaarboekje dat in de wieg begint
Halkin, V; Reginster, Jean-Yves ULg

in De Agenda Pediatrie (2000), 22

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See detailBiocompatibility of polyethylene glycols (PEG): An approach using bovine serum albumin (BSA) as a protein model.
Loret, S; Gilson, P; Barakat, I et al

in Pflügers Archiv : European Journal of Physiology (2000), 440

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2000)

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See detailMetallothioneins in Marine Mammals
Das, Krishna ULg; Debacker, Virginie ULg; Bouquegneau, Jean-Marie ULg

in Cellular and Molecular Biology (2000), 46(2),

Metallothioneins (MTs) have been detected in livers and kidneys of 10 marine mammals species (Pinnipeds and Odontocetes). Characterization of renal MTs of striped dolphin has shown that the protein has ... [more ▼]

Metallothioneins (MTs) have been detected in livers and kidneys of 10 marine mammals species (Pinnipeds and Odontocetes). Characterization of renal MTs of striped dolphin has shown that the protein has two isoforms (MT-1 and MT-2) with a molecular weight estimated around 6,800. MT concentrations also vary widely in marine mammals tissues (from 58 to 1,200 microg x g(-1) ww) underlying the numerous parameters involved: physiological status, pregnancy, age, diet. The participation of this protein in metal detoxification has been investigated since high levels of cadmium (Cd) and mercury (Hg) have been measured in livers and kidneys of marine mammals. It has been suggested that those animals can mitigate at least in part, the toxic effects of Cd and Hg through binding to MTs. The percentage of the cytosolic Cd bound to MTs can reach almost 100%. On the contrary, the percentage of hepatic and renal Hg bound to MT is very low (generally less than 10%) and this metal is mainly associated with selenium (HgSe) under a detoxified form in the insoluble fraction of the tissues. MTs appear to play a minor role in the binding and detoxification of Hg by marine mammals. On the contrary, close and dynamic interactions occur between Cd and MTs. Cytosolic MTs appear as a potential short term way of detoxification of Cd accumulated from diet. Long-term detoxification would imply a sequestration of the metal under a precipitated form (e.g. in lysosomes). [less ▲]

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See detailLandmarks in the theory of mass spectra
Lorquet, Jean-Claude ULg

in International Journal of Mass Spectrometry (2000), 200(1-3), 43-56

Statistical theories of mass spectra are based on two assumptions. The first one, which postulates efficient phase space sampling, is substantiated by various experimentation and is now theoretically much ... [more ▼]

Statistical theories of mass spectra are based on two assumptions. The first one, which postulates efficient phase space sampling, is substantiated by various experimentation and is now theoretically much better understood. The efficiency of phase space sampling can be estimated and is found to be quite good. Much effort remains to be done concerning the second assumption. A new impetus should be given to the concept of transition state. A better understanding of the role played by the conservation of angular momentum, the exact significance of transition state switching, and the incorporation of quantum effects are set as goals for the future. © 2000 Elsevier Science B.V. [less ▲]

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See detailChanges in the moss layer after liming in a Norway spruce (Picea abies (L.) Karst.) stand of Eastern Belgium
Dulière, J.-F.; De Bruyn, R.; Malaisse, François ULg

in Forest Ecology & Management (2000), 136(1-3), 97-105

The impact of dolomite lime (5 t ha -1) on the moss layer was investigated in a Belgian Norway spruce (Picea abies (L.) Karst.) forest. Bryophytes reacted rapidly, showing a decrease in frequency, cover ... [more ▼]

The impact of dolomite lime (5 t ha -1) on the moss layer was investigated in a Belgian Norway spruce (Picea abies (L.) Karst.) forest. Bryophytes reacted rapidly, showing a decrease in frequency, cover and biomass of acidophilous dominant Dicranaceae species. Some neutrophilous competitive or stress tolerant species were spreading out and some ruderals appeared. The reaction of the dominant species coverage to different liming rates was also considered. Results showed that the negative effect was more pronounced than higher dolomite doses were. (C) 2000 Elsevier Science B.V. [less ▲]

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See detailGenetic organisation of the lipopolysaccharide O-antigen biosynthesis region of brucella melitensis 16M (wbk).
Godfroid, F.; Cloeckaert, A.; Taminiau, Bernard ULg et al

in Research in Microbiology (2000), 151(8), 655-68

Brucella spp. are Gram-negative, facultative intracellular bacteria that cause a zoonotic world-wide disease. As in other Gram-negative bacteria, its S-LPS (smooth lipopolysaccharide) is a major ... [more ▼]

Brucella spp. are Gram-negative, facultative intracellular bacteria that cause a zoonotic world-wide disease. As in other Gram-negative bacteria, its S-LPS (smooth lipopolysaccharide) is a major determinant of virulence. The Brucella melitensis 16M LPS O-antigen is a homopolymer of 4-formamido-4,6, dideoxymannose. In this study, the previously cloned 14-kb wbk gene cluster was sequenced, and seven open reading frames (ORFs) as well as four insertion sequences were identified. Six of the seven ORFs are homologous to LPS biosynthesis genes from other organisms. The gmd, per and wbkC gene products are predicted to be involved in 4-formamido-4,6,dideoxymannose synthesis. By deletion experiments, we demonstrated that the putative formyltransferase WbkC is absolutely required for the O-side-chain production. The wbkA gene product is similar to several mannosyltransferases and is probably involved in the polymerisation of the B. melitensis O-side-chain. We also identified two genes (wzm and wzt) encoding proteins with high similarity to several two-component ABC (ATP-binding cassette) transporters. Their implication in O-antigen translocation across the inner membrane was confirmed by gene replacement. Finally, no function has been assigned to the wbkB gene either by homology search or functionally, because deletion of wbkB did not interfere with the O-antigen structure. The seven ORFs have a low G + C content, indicating that they might have been acquired by lateral transfer from a progenitor with more A + T rich DNA. [less ▲]

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See detailRelationship between CNV topography and irritability in depression
Papart, Patrick ULg; WEERTS, Pascale ULg; Pinto, Emmanuel ULg et al

in Journal of Psychophysiology (2000), 14(Suppl 1),

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See detailFerroelectricity in PbTiO3 thin films: A first principles approach
Rabe, K. M.; Ghosez, Philippe ULg

in Journal of Electroceramics (2000), 4(2-3), 379-383

The ground-state ferroelectric distortion of PbTiO3 thin films is studied using a first-principles effective Hamiltonian to describe the structural energetics at a microscopic level. Under short-circuit ... [more ▼]

The ground-state ferroelectric distortion of PbTiO3 thin films is studied using a first-principles effective Hamiltonian to describe the structural energetics at a microscopic level. Under short-circuit electrical and zero-stress mechanical boundary conditions, (0 0 1) films as thin as one unit cell are found to support a stable perpendicular polarization. Size effects in the layer-by-layer ferroelectric distortion are discussed. The continuum limit of the first-principles effective Hamiltonian has the same form as the widely-used Landau-Ginzburg expression for the free energy near T-c, so that the present results can be directly related to those of previous phenomenological studies. In particular, a microscopic interpretation of the extrapolation length delta is proposed. [less ▲]

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See detailMorphodynamisme d'un tronçon de la Loire bourbonnaise depuis le XVIIIe siècle
Leteinturier, B.; Engels, Patrick ULg; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2000)

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See detailIpsilateral motor responses to focal transcranial magnetic stimulation in normal and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; GERARD, Pascale ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2000), Neurosurgery and Psychiatry

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See detailProjectively Equivariant Symbol Calculus for Bidifferential Operators
Boniver, Fabien ULg

in Letters in Mathematical Physics (2000), 54(2), 83-100

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See detailSyntaxe et sens de la tournure védique prathamam jayamânah
Swennen, Philippe ULg

in A.I.O.N. Annali dell'Istituto Universitario Orientale di Napoli. Sezione filologico-letteraria (2000), 60-61

The Vedic locution prathamam jâjyamânah is a syntagm, where the first word, used as an adverb, means that the action expressed by the participle happens just before the action of the main verb of the ... [more ▼]

The Vedic locution prathamam jâjyamânah is a syntagm, where the first word, used as an adverb, means that the action expressed by the participle happens just before the action of the main verb of the sentence. Once this rule is established, other examples of this use of prathamam can be identified. This turn, very rare in the texts, was archaic and finally disappeared. [less ▲]

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See detailLe financement public des cultes, de la laïcité et des cours philosophiques
Husson, Jean-François ULg

in Courrier Hebdomadaire du CRISP (2000), (1703-1704), 3-90

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described ... [more ▼]

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described. Detailed budgetary data are provided and are set in perspective with sociological data on religious practices or belonging. [less ▲]

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See detailA survey on staging and treatment in uterine cervical carcinoma in the Radiotherapy Cooperative Group of the European Organization for Research and Treatment of Cancer
Coucke, Philippe ULg; Maingon, P; Ciernik, I et al

in Radiotherapy & Oncology (2000), 54

Abstract Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the ... [more ▼]

Abstract Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the European Organization for Research and Treatment of Cancer (EORTC), we conducted a survey in 1997±1998 to determine the variability of pre-treatment assessment and treatment options. The variability of choosing surgery, de®ned radiation therapy techniques and chemotherapy are investigated, as well as the center's choices of future treatment strategies. Methods: Fifty two of 81 RCG centers from the RCG have participated in the survey. As one would expect, there is a large variation in the techniques used for pretreatment evaluation and treatment options. There is no `standard' for reporting acute and late side effects. Chemotherapy is used neither systematically nor uniformly, and some centers continue to use neadjuvant chemotherapy modalities. Results: Furthermore, the survey reveals that there is a strong demand for the reduction of overall treatment-time, for clinical investigation of novel combined modality treatment strategies, especially chemo±radiation therapy, and also for the use of new radiation sensitizers. Conclusion:We conclude that a more homogeneous approach to the pretreatment evaluation as well as treatment techniques is required in order to allow adequate quality control in any future trial of the RCG in the EORTC.q2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailNeural mechanisms of antinociceptive effects of hypnosis.
Faymonville, Marie ULg; Laureys, Steven ULg; Degueldre, Christian ULg et al

in Anesthesiology (2000), 92(5), 1257-67

BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the ... [more ▼]

BACKGROUND: The neural mechanisms underlying the modulation of pain perception by hypnosis remain obscure. In this study, we used positron emission tomography in 11 healthy volunteers to identify the brain areas in which hypnosis modulates cerebral responses to a noxious stimulus. METHODS: The protocol used a factorial design with two factors: state (hypnotic state, resting state, mental imagery) and stimulation (warm non-noxious vs. hot noxious stimuli applied to right thenar eminence). Two cerebral blood flow scans were obtained with the 15O-water technique during each condition. After each scan, the subject was asked to rate pain sensation and unpleasantness. Statistical parametric mapping was used to determine the main effects of noxious stimulation and hypnotic state as well as state-by-stimulation interactions (i.e., brain areas that would be more or less activated in hypnosis than in control conditions, under noxious stimulation). RESULTS: Hypnosis decreased both pain sensation and the unpleasantness of noxious stimuli. Noxious stimulation caused an increase in regional cerebral blood flow in the thalamic nuclei and anterior cingulate and insular cortices. The hypnotic state induced a significant activation of a right-sided extrastriate area and the anterior cingulate cortex. The interaction analysis showed that the activity in the anterior (mid-)cingulate cortex was related to pain perception and unpleasantness differently in the hypnotic state than in control situations. CONCLUSIONS: Both intensity and unpleasantness of the noxious stimuli are reduced during the hypnotic state. In addition, hypnotic modulation of pain is mediated by the anterior cingulate cortex. [less ▲]

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See detailWegwijs in de vele benamingen van de veelvormige pathogeen Escherichia coli
Mainil, Jacques ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

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See detailAerosol therapy in veterinary medicine : is it the future ?
Lekeux, Pierre ULg

in Veterinary Journal (2000), 160

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See detailRythmes du temps: de l'Astronomie à l'Histoire
Biémont, Emile ULg

in Ciel et Terre (2000), 116(3), 72-81

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See detailPreliminary survey of the palynological content of the Lower Devonian in the Oesling, Luxembourg
Steemans, Philippe ULg; Debbaut, Vincent ULg; Faber, A.

in Bulletin de la Société des Naturalistes Luxembourgeois (2000), 100

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See detailMieux connaître la forêt privée. Appel aux propriétaires.
Rondeux, Jacques ULg; Bourland, Nils ULg

in Silva Belgica (2000), 107(1), 28-29

Dans le cadre de l'appui scientifique à l'Inventaire permanent des Ressources ligneuses de Wallonie, l'Unité de Gestion et Economie forestières (Prof. J. RONDEUX) de la Faculté universitaire des Sciences ... [more ▼]

Dans le cadre de l'appui scientifique à l'Inventaire permanent des Ressources ligneuses de Wallonie, l'Unité de Gestion et Economie forestières (Prof. J. RONDEUX) de la Faculté universitaire des Sciences agronomiques de Gembloux (FUSAGx) a été chargée de compléter l'information générale relative à la forêt privée, en particulier pour mieux identifier son degré de morcellement et l'évolution attendue de celui-ci dans un avenir proche. Ce travail est réalisé en étroite collaboration avec la Cellule Inventaire des Ressources ligneuses Wallonnes (Ir. H. LECOMTE) et bénéficie du soutien de la Société Royale Forestière de Belgique. [less ▲]

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See detailLexique des termes de physiologie et de pathologie et performances de reproduction chez les bovins
Badinand, F.; Bedouet, J.; Cosson, J. L. et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailLa garantie des droits fondamentaux et la convention européenne des droits de l'homme
Carlier, Jean-Yves ULg

in Revue Québecoise de Droit International (2000), 13(1), 37-62

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See detailA natural dominant negative P2X1 receptor due to deletion of a single amino acid residue.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Van Geet, Chris et al

in Journal of Biological Chemistry (2000)

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354 ... [more ▼]

We describe a naturally occurring dominant negative P2X1 mutant. This mutant lacks one leucine within a stretch of four leucine residues in its second transmembrane domain (TM2) (amino acids 351-354). Confocal microscopy revealed proper plasma membrane localization of the mutant in stably transfected HEK293 cells. Nevertheless, voltage-clamped HEK293 cells expressing mutated P2X1 channels failed to develop an ATP or ADP-induced current. Furthermore, when co-expressed with the wild type receptor in Xenopus oocytes, the mutated protein exhibited a dose-dependent dominant negative effect on the normal ATP or ADP-induced P2X1 channel activity. These data indicate that deletion of a single apolar amino acid residue at the inner border of the P2X1 TM2 generates a nonfunctional channel. [less ▲]

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See detailHigh-energy forward scattering and the pomeron: Simple pole versus unitarized models
Cudell, Jean-René ULg; Ezhela, V.; Kang, K. et al

in Physical Review. D : Particles and Fields (2000), 61

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See detailPerformance of Belgian general practitioners: a "best practice approach based on patient level data"
Fecher-Bourgeois, Fabienne ULg; Gillet, Pierre ULg

in Cahiers Economiques de Bruxelles (2000), 167(3ème trimestre 2000), 381-396

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See detailInvolvement of acyl coenzyme A oxidase isozymes in biotransformation of methyl ricinoleate into γ-decalactone by Yarrowia lipolytica
Waché, Y.; Laroche, C.; Bergmark, K. et al

in Applied and Environmental Microbiology (2000), 66(3), 1233-1236

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes ... [more ▼]

We reported previously on the function of acyl coenzyme A (acyl-CoA) oxidase isozymes in the yeast Yarrowia lipolytica by investigating strains disrupted in one or several acyl-CoA oxidase-encoding genes (POX1 through POX5) (H. Wang et al., J. Bacteriol. 181:5140-5148, 1999). Here, these mutants were studied for lactone production. Monodisrupted strains produced similar levels of lactone as the wild-type strain (50 mg/liter) except for Δpox3, which produced 220 mg of γ-decalactone per liter after 24 h. The Δpox2 Δpox3 double-disrupted strain, although slightly affected in growth, produced about 150 mg of lactone per liter, indicating that Aox2p was not essential for the biotransformation. The Δpox2 Δpox3 Δpox5 triple- disrupted strain produced and consumed lactone very slowly. On the contrary, the Δpox2 Δpox3 Δpox4 Δpox5 multidisrupted strain did not grow or biotransform methyl ricinoleate into γ-decalactone, demonstrating that Aox4p is essential for the biotransformation. [less ▲]

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See detailL'humanisme face au terrorisme
Seron, Vincent ULg

in Cahiers de défense sociale (2000)

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See detailÀ la recherche de l'«art public» dans les villes de la Mésopotamie
Tunca, Önhan ULg

in Art&Fact (2000), 19

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See detailLifetimes of metastable state in Sr II
Biémont, Emile ULg; Lidberg, J.; Mannervik, S. et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2000), 11

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See detailTransition rates of the resonance line doublet in the Cl I sequence, Ar II to Ge XVI
Biémont, Emile ULg; Träbert, E.

in Journal of Physics : B Atomic Molecular & Optical Physics (2000), 33

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See detailElectrophysiological behavior of Purkinje cells and motor coordination in calretinin knock-out mice
Cheron, Guy; Schurmans, Stéphane ULg; Lohof, Ann et al

in Progress in Brain Research (2000), 124

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See detailClinical impact and perspectives of 18F-FDG PET in lymphoma
Jerusalem, Guy ULg; Beguin, Yves ULg

in Clinical Lymphoma (2000), 1

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See detailViolence et adolescent, un lien naturel?
Malchair, Alain ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2000), (2), 23-26

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See detailRespiration As The Main Determinant Of Carbon Balance In European Forests
Valentini, R.; Matteucci, G.; Dolman, Aj. et al

in Nature (2000), 404(6780),

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See detailLinear growth and final height after treatment for Cushing's disease in childhood.
LEBRETHON, Marie-Christine ULg; Grossman, A. B.; Afshar, F. et al

in The Journal of clinical endocrinology and metabolism (2000), 85(9), 3262-5

Cushing's disease is associated with growth failure in childhood and adolescence. Growth and final height were analyzed in 10 patients who were cured or in remission after treatment of Cushing's disease ... [more ▼]

Cushing's disease is associated with growth failure in childhood and adolescence. Growth and final height were analyzed in 10 patients who were cured or in remission after treatment of Cushing's disease. Seven males and 3 females, aged 6.8-17.6 yr (bone age, 3.3-15.4 yr), had transsphenoidal surgery, which was combined with pituitary irradiation (4,500 cGy in 25 fractions) in 5 patients. At presentation, 5 patients were prepubertal (males), and 5 were pubertal (2 males and 3 females). The mean height SD score was -2.15 +/-1.26 (range, -0.21 to -4.32) compared with mean target height SD score of -0.43 +/- 0.58. Height velocity in 6 patients was subnormal (0.9-3.8 cm/yr). After treatment, short-term height velocity, over a mean interval of 0.57 yr, in 8 patients not receiving human GH (hGH) therapy, was variable (range, 0.8-7.6 cm/yr). GH stimulation tests (insulin tolerance test/glucagon) in 9 subjects showed peak GH levels of 0.5-20.9 mU/L. Eight were treated with hGH (14 IU/m2 wk), combined in 2 girls and 1 boy with a GnRH analog. After 1 yr of hGH, the mean height SD score had increased from -2.45 +/- 1.0 at initiation of hGH to -2.07 +/- 1.2 (P = 0.01). GH therapy was continued until final height or latest assessment. The mean final height SD score (n = 6) was - 1.24 +/- 1.38, and at the latest assessment the mean height SD score (n = 4) was - 1.52 +/- 1.33. Combining these 2 groups, the mean height so score was -1.36 +/- 1.29. The difference between final or latest height SD score and target height SD score was 0.93 +/- 1.13, i.e. less (P = 0.005) than the difference between height and target height SD score of 1.72 +/- 1.26 at presentation. In conclusion, catch-up and favorable long-term growth was seen after treatment for Cushing's disease. Posttreatment GH deficiency was frequent, and early hGH replacement may have contributed to the encouraging outcome. [less ▲]

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See detailA simple method for neutrophils isolaton in horse
Votion, Dominique ULg; Harmegnies, N. F.; Lekeux, Pierre ULg

in European Journal of Nuclear Medicine (2000), 27

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See detailProduire de l'écrit en cycle ... : de la maternelle au degré inférieur de l'enseignement primaire
Hindryckx, Geneviève ULg; Nyssen, Marie-Claire ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (1-2), 18-31

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See detailObs. sous Cass., 8 avril 1999
Delnoy, Michel ULg

in Aménagement - Environnement (2000), 2

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See detailParticularités de la prise en charge de l’excès pondéral chez l’adolescent : résultats d’une enquête exploratoire
Glowacz, Fabienne ULg; Bourguignon, J. P.; Born, Michel ULg

in Bulletin d’Education du Patient (2000), 19(3), 132-140

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See detailLe maître de Waha : un exemple de développement durable
Van Ruymbeke, Muriel ULg

in De la Meuse à l'Ardenne (2000), (31), 104-106

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See detailCompte rendu de Mélanges L. FALKENSTEIN
George, Philippe ULg

in Moyen Age (Le) (2000)

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See detailLoss of plant organogenic totipotency in the course of in vitro neoplastic progression
Gaspar, Thomas ULg; Kevers, Claire ULg; Bisbis, Badia et al

in In Vitro Cellular & Developmental Biology-Plant (2000), 36(3), 171-181

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under ... [more ▼]

The aptitude for organogenesis from normal hormone-dependent cultures very commonly decreases as the tissues are serially subcultured. The reasons for the loss of regenerative ability may vary under different circumstances: genetic variation in the cell population, epigenetic changes, disappearance of an organogenesis-promoting substance, etc. The same reasons may be evoked for the progressive and eventually irreversible loss of organogenic totipotency in the course of neoplastic progressions from hormone-independent tumors and hyperhydric teratomas to cancers. As in animal cells, plant cells at the end of a neoplastic progression have probably undergone several independent genetic accidents with cumulative effects. They indeed are characterized by atypical biochemical cycles from which they are apparently unable to escape. The metabolic changes are probably not the primary defects that cause cancer, rather they may allow the cells to survive. How these changes, namely an oxidative stress, affect organogenesis is not known. The literature focuses on somatic mutations and epigenetic changes that cause aberrant regulation of cell cycle genes and their machinery. [less ▲]

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See detailOn the scalar meson exchange in the baryon spectra
Stassart, Pierre ULg; Stancu, Floarea ULg; Richard, J. M. et al

in Journal of Physics : G Nuclear & Particle Physics (2000), G26

We explore the role of a scalar meson exchange interaction between quarks in a semirelativistic constituent quark model where the quarks are also subject to a linear confinement. We study how the spectrum ... [more ▼]

We explore the role of a scalar meson exchange interaction between quarks in a semirelativistic constituent quark model where the quarks are also subject to a linear confinement. We study how the spectrum evolves when the strength of the scalar meson exchange increases. Our results are relevant to the long-standing problem of the relative position of the first positive-parity (Roper resonance) and the first orbitally excited states in the baryon spectrum. [less ▲]

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See detailImpact of attenuation correction on the accuracy of FDG-PET in patients with abdominal tumors: a free-response ROC analysis.
Hustinx, Roland ULg; Dolin, R. J.; Benard, F. et al

in European Journal of Nuclear Medicine (2000), 27(9), 1365-71

The aim of this study was to evaluate image quality and lesion detectability with and without attenuation correction in patients with abdominal tumors, using a free-response receiver operating ... [more ▼]

The aim of this study was to evaluate image quality and lesion detectability with and without attenuation correction in patients with abdominal tumors, using a free-response receiver operating characteristic (FROC) methodology. Thirty-four patients with various abdominal tumors were evaluated (11 men, 23 women, median age 48 years). Whole-body emission scans were performed 68 min (35-102 min) after intravenous injection of 4.3 MBq/kg fluorine-18 fluorodeoxyglucose (FDG). Images were reconstructed using the OS-EM algorithm and corrected for attenuation either using postinjection singles transmission (n=27) or by calculation and body outline (n=7). Total scan duration did not exceed 70 min. Studies were read independently by four observers unaware of any clinical data. The uncorrected (UC) images were systematically read before the attenuation-corrected (AC) images. All studies were given an image quality score ranging from 1 (unreadable) to 5 (excellent). Each focus of increased activity was then localized and given a probability of malignancy using a five-point scale. The average image quality score was similar for both UC and AC images. At the time of the positron emission tomography (PET) scans, 127 lesions (63 liver metastases, 9 retroperitoneal lesions, 50 peritoneal or bowel lesions, and 5 pancreatic carcinomas) were revealed by pathological or correlative studies. The areas under the FROC curves were consistently greater for AC images (range 0.8663-0.8867) than for UC images (range 0.7774 -0.8613). Overall, the difference between the AC images and the UC images was significant (P=0.019). In particular, correction for attenuation increased the sensitivity regardless of the location of the lesions. In conclusion, correction for attenuation significantly improves the diagnostic accuracy of FDG-PET for abdominal staging of neoplasms, without impairing the image quality. [less ▲]

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See detailPercolation as a model for informetric distributions: fragment size distribution characterised by Bradford curves
Bogaert, Jan ULg; Rousseau, R; Van Hecke, P

in Scientometrics (2000), 47(2), 195-206

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See detailConstructions and applications of wavelets in Sobolev spaces
Bastin, Françoise ULg

in Revista Ciencias Matematicas (2000), 18(2), 145-177

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See detailCompétition et choix du partenaire sexuel chez les primates
Huynen, Marie-Claude ULg

in Cahiers d'Ethologie (2000), 20(1), 85-112

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See detailRevue bibliographique : l’hydroperoxyde lyase
Delcarte, Jérome; Fauconnier, Marie-Laure ULg; Hoyaux, Phryné et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(3), 157-167

The hydroperoxide lyase belongs to the lipoxygenase pathway, pathway in which polyunsaturated fatty acids are transformed into a large spectrum of compounds with various chemical and biological functions ... [more ▼]

The hydroperoxide lyase belongs to the lipoxygenase pathway, pathway in which polyunsaturated fatty acids are transformed into a large spectrum of compounds with various chemical and biological functions. The hydroperoxide lyase acts on fatty acids hydroperoxides (mainly linoleic and linolenic). It cleaves the bond between carbon carrying the hydroperoxide function and a vicinal carbon giving an w-oxo-acid and also depending on the species, an aldehyde, a hydrocarbon or an alcohol. [less ▲]

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See detailBiotransformation of ricinoleic acid into g-decalactone by yeast cells: recent progress and current questions
Aguedo, Mario ULg; Waché, Yves; Belin, J.M.

in Recent Research Developments in Biotechnology & Bioengineering (2000), 3

Lactone aroma compounds production can be achieved biotechnologically by microbial fermentation and notably using yeasts. Many studies have been carried out to understand the mechanisms implicated in such ... [more ▼]

Lactone aroma compounds production can be achieved biotechnologically by microbial fermentation and notably using yeasts. Many studies have been carried out to understand the mechanisms implicated in such bioreactions, and a pathway involving peroxisomal β-oxidation was established but some unelucidated points remain. In the recent years, new developments appeared proposing biotechnological ways to overcome and understand lactone toxicity or its commonly observed reconsumption and trying to explain some confused points like fatty acid emulsification, entry and storage into the cell. The importance of acyl-CoA oxidases in the metabolic pathway implicated and thus in the lactone production as well as on its reconsumption was also focused. Simultaneously with a presentation of the biotransformation pathways, these points are discussed in the light of new data including not yet published data obtained mainly with the yeast Yarrowia lipolytica. [less ▲]

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See detailEffect of grade on disease-free survival and overall survival in FIGO Stage I adenocarcinoma of the endometrium.
Delaloye, J-F; Pampallona, S; COUCKE, Philippe ULg et al

in European Journal of Obstetrics & Gynecology & Reproductive Biology (2000), 88

Abstract Objective : To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods ... [more ▼]

Abstract Objective : To analyse the effect of differentiation on disease-free survival (DFS) and overall survival (OS) in patients with stage I adenocarcinoma of the endometrium. Patients and methods : From 1979 to 1995, 350 patients with FIGO stage IA–IC with well (G1), moderately (G2) or poorly (G3) differentiated tumors were treated with surgery and high dose-rate brachytherapy with or without external radiation. Median age was 65 years (39–86 years). Results : The 5-year DFS was 8863% for the G1 tumors, 7764% for the G2 tumors, and 6767% for the G3 tumors (P50.0049). With regard to the events contributing to DFS, the 5-year cumulative percentage of local relapse was 4.6% for the G1 tumors, 9.0% for the G2 tumors, and 4.6% (P50.027) for the G3 tumors. Cumulative percentage of metastasis was 1.4, 6.3 and 7.2% (P,0.001), respectively, whereas percentages of death were 6.0, 7.9 and 20.7% (P,0.001). The 5-year OS was 9163, 8364 and 7667%, respectively (P50.0018). In terms of multivariate hazard ratios (HR), the relative differences between the three differentiation groups correspond to an increase of 77% of the risk of occurrence of either of the three events considered for the DFS (HR51.77, 95% Cl [0.94–3.33]), (P50.078) for the G2 tumors and of 163% (HR52.63, 95% Cl [1.27–5.43]), (P50.009) for the G3 tumors with respect to the G1 tumors. The estimated relative hazards for OS are, respectively, in line with those for DFS: HR51.51 (P50.282) for the G2 tumors; and HR53.37 (P50.003) for the G3 tumors. Conclusion : Patients with grade 1 tumors are those least exposed to either local relapse, metastasis, or death. In contrast patients with grade 2 tumors seem to be at higher risk of metastasis, whereas patients with grade 3 tumors appear at higher risk of death. Since we have looked at the first of three competing events (local relapse, metastasis and death), this suggests that patients with grade 3 tumors probably progress to death so fast that local relapse, if any, cannot be observed. Ó 2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailTreatment outcome in infant acute lymphoblastic leukemia
Ferster, A; Benoit, Y; Francotte, N et al

in Blood (2000), 95(8), 2729-31

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See detail"J'ai deux ‘amours’…"
Dejasse, Erwin ULg

in Art&Fact (2000), 19

The representations of Paris into the comic "Adèle Blanc-Sec" by Jacques Tardi.

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See detailProbing Organization and Structural Characteristics of Alkanethiols Adsorbed on Gold and of Model Alkane Compounds through their Valence Electronic Structure: an Ultraviolet Photoelectron Spectroscopy Study
Duwez, Anne-Sophie ULg; Pfister-Guillouzo, G.; Delhalle, Joseph et al

in Journal of Physical Chemistry B (2000), 104

In this paper we report an ultraviolet photoelectron spectroscopy (UPS) study of saturated alkane chains in various configurations and conformations. The dependence of the valence spectra on molecular ... [more ▼]

In this paper we report an ultraviolet photoelectron spectroscopy (UPS) study of saturated alkane chains in various configurations and conformations. The dependence of the valence spectra on molecular structure characteristics has been assessed by comparing the results obtained from n-alkanethiol, R,ö-alkanedithiol, and R-cycloalkyl-ö-alkanethiol monolayers adsorbed on gold, and from gas-phase model alkane compounds. The differences between the spectra reflect directly the structural changes induced in the electronic structure of the alkane chains. We have determined the type of folding sequences adopted in a 1,12-dodecanedithiol monolayer. Angular dependent measurements and investigations on the photoelectron attenuation length have evidenced very fine structural differences between films obtained on deposited gold films, annealed gold films, and gold single crystals [less ▲]

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See detailÉric Benoît, Les Poésies de Mallarmé et Mallarmé et le Mystère du « Livre »
Durand, Pascal ULg

in Littératures Classiques (2000), 43(automne), 173-180

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See detailEclipse totale du 11 août 1999 et évolution de la basse ionosphère
Delcourt, J. J.; Jodogne, J.-C.; Biémont, Emile ULg

in Ciel et Terre (2000), 116(1), 6-7

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See detailSynthesis of an array antenna for hyperthermia applications
V Sabariego, Ruth ULg; Landesa, Luis; Obelleiro, Fernando

in IEEE Transactions on Magnetics (2000), 36(4), 1696-1699

In the present work the synthesis of an array antenna for hyperthermia treatment is developed. The selected antenna is an array antenna surrounded by a semicircular reflector which has shown to ease the ... [more ▼]

In the present work the synthesis of an array antenna for hyperthermia treatment is developed. The selected antenna is an array antenna surrounded by a semicircular reflector which has shown to ease the penetration and focalization in malignant biological tissues. A bolus is introduced as a protection in order to avoid an increasing heat hazard of superficial healthy tissues. The electric field within the biological medium will be modeled by means of the well known method of moments. The electromagnetic coupling problem is expressed in a closed form, enabling both a synthesis and an optimization procedure to be performed. Numerical results are included, illustrating the capabilities of the array antenna. [less ▲]

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See detailImmunocytochemical localization of ionotropic glutamate receptors subunits in the adult quail forebrain
Cornil, Charlotte ULg; Foidart, Agnès ULg; Minet, Arlette ULg et al

in Journal of Comparative Neurology (The) (2000), 428

The excitatory amino acid glutamate is implicated in the central control of many neuroendocrine and behavioral processes. The ionotropic glutamate receptors are usually divided into the N-methyl-D ... [more ▼]

The excitatory amino acid glutamate is implicated in the central control of many neuroendocrine and behavioral processes. The ionotropic glutamate receptors are usually divided into the N-methyl-D-aspartate (NMDA) and non-NMDA (kainate and AMPA) subtypes. Subunits of these receptors have been cloned in a few mammalian species. Information available in birds is more limited. In quail, we recently demonstrated that glutamate agonists (kainate, AMPA, and NMDA) rapidly (within minutes) and reversibly decrease in vitro aromatase activity like several other manipulations affecting intracellular HCa21 pools. Aromatase catalyzes the conversion of androgens into estrogens which is a limiting step in the control by testosterone of many behavioral and physiologic processes. Therefore, glutamate could control estrogen production in the brain, but the anatomic substrate supporting this effect is poorly understood. In quail, aromatase is mainly localized in the preoptic-hypothalamic-limbic system. We visualized here the distribution of the major ionotropic glutamate receptors in quail by immunocytochemical methods by using commercial primary antibodies raised against rat glutamate receptor 1 and receptors 2-3 (GluR1, GluR2/3: AMPA subtype, Chemicon, CA), rat glutamate receptors 5-7 (GluR5-7: kainate subtype, Pharmingen, CA), and rat NMDA receptors (NMDAR1, Pharmingen, CA). Dense and specific signals were obtained with all antibodies. The four types of receptors are broadly distributed in the brain, and, in particular, immunoreactive cells are identified within the major aromatase cell groups located in the medial preoptic nucleus, ventromedial hypothalamus, nucleus striae terminalis, and nucleus taeniae. Dense specific populations of glutamate receptor immunoreactive cells are also present with a receptor subtype-specific distribution in broad areas of the telencephalon. The distribution of glutamate receptors, therefore, is consistent with the idea that these receptors could be located at the surface of aromatase-containing cells and mediate the rapid regulation of aromatase activity in a direct manner. [less ▲]

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See detailComparaison des treillis classiques de type Warren, Pratt et Howe : optimisation et prédimensionnement sur base d'indicateurs morphologiques
Latteur, Pierre ULg; Samyn, Philippe; De Wilde, Patrick

in Revue Française de Génie Civil (2000), 4

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See detailNote sous Bruxelles, 23 septembre 1999
Thirion, Nicolas ULg

in Droit des Affaires : Revue Internationale du Droit des Affaires = Ondernemingsrecht : Internationaal Tijdschrift voor Ondernemingsrecht [= DA OR] (2000), 55

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See detail"note sous J.P. Jumet, 9 mai 2000"
Moreau, Pierre ULg

in Actualités du Droit (2000)

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See detailInterplay of anisotropy and competing correlated pinning mechanisms in the angular dependence of the irreversible magnetization of YBa2Cu3O7 crystals
Silhanek, Alejandro ULg; Civale, L.

in Physica C: Superconductivity (2000), 341(Part 2), 1227-1228

We measured the angular dependence of the irreversible magnetization of a YBa2Cu3O7 single crystal with columnar defects (CD) inclined with respect to the c-axis. At temperatures T greater than or equal ... [more ▼]

We measured the angular dependence of the irreversible magnetization of a YBa2Cu3O7 single crystal with columnar defects (CD) inclined with respect to the c-axis. At temperatures T greater than or equal to 40K and high fields we observe a sharp maximum centered at the tracks' direction. At T less than or equal to 20K the behavior is quite different. At high fields a broad bump at the tracks' direction is still visible, but its height is small and it appears only as a perturbation to the angular dependence due to material anisotropy. However, by performing the usual anisotropic rescaling (Blatter et al., Phys. Rev. Lett. 68, 875, 1992) we recover the strong unidirectional effects due to CD's. [less ▲]

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See detailCas clinique pour la rubrique “ Imagerie médicale ”
Noels, C.; Busoni, Valeria ULg

in Pratique Vétérinaire Equine (2000)

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See detailThe influence of facial emotion displays gender, and ethnicity on judgments of dominance and affiliation
Hess, U; Blairy, Sylvie ULg; Kleck, R

in Journal of Nonverbal Behavior (2000), 24(4), 265-283

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See detailDetermination of Alpha-Solanine and Alpha-Chaconine in Potatoes by High-Performance Thin-Layer Chromatography/Densitometry
Bodart, P.; Kabengera, C.; Noirfalise, Alfred ULg et al

in Journal of AOAC International (2000), 83(6, Nov-Dec), 1468-73

A high-performance thin-layer chromatographic (HPTLC) method was used to determine the glycoalkaloids alpha-solanine and alpha-chaconine in potatoes. Alpha-solanine and alpha-chaconine are extracted from ... [more ▼]

A high-performance thin-layer chromatographic (HPTLC) method was used to determine the glycoalkaloids alpha-solanine and alpha-chaconine in potatoes. Alpha-solanine and alpha-chaconine are extracted from dehydrated potatoes with boiling methanol-acetic acid (95 + 5, v/v). The analytes are separated on a Silica Gel 60 F254 HPTLC plate by a saturated mixture of dichloromethane-methanol-water-concentrated ammonium hydroxide (70 + 30 + 4 + 0.4, v/v), which is used for vertical development of the plate up to a distance of 85 mm. For visualization, the plate is dipped 3 times into a modified Carr-Price reagent, 20% (w/v) antimony(III) chloride in acetic acid-dichloromethane (1 + 3, v/v), and subsequently heated on a hot plate at 105 degrees C for 5 min. The glycoalkaloids all appear as red chromatographic zones on a colorless background. Densitometric quantification is performed at 507 nm by reflectance scanning. After determination of the appropriate response function, the proposed method was validated. Good results with respect to linearity, accuracy, and precision were obtained in the concentration range studied. [less ▲]

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See detailRespiratory responses of mature horses to intravenous lobeline bolus
Marlin, D. J.; Roberts, C. A.; Schroter, R. C. et al

in Equine Veterinary Journal (2000), 32(3), 200-207

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway ... [more ▼]

The respiratory stimulant lobeline has been used in equine clinical practice to increase inspiratory and expiratory airflow rates at rest in orderto facilitate investigation of both lower and upper airway function. Some of the responses to lobeline in the pony have been reported, but the detailed time course, effect of dose, possible side effects and reproducibility associated with lobeline administration have not been described in the horse. Respiratory airflow rates and oesophageal pre s s u re were measured with a Fleisch No. 5 pneumotachometer and lightweight facemask and amicrotip pressure transducer catheter, respectively. The output of the Fleisch pneumotachometer was calibrated for flow rates up to ± 70 l/s. Seven mature horses with no clinical signs of respiratory disease were studied. Investigations were conducted to determine: (1) the responses to different doses of lobeline (0.15, 0.20, 0.25 and 0.30 mg/kg bwt) as a rapid i.v. bolus (6 horses); (2) arterial blood gases during and after lobeline administration (0.20 mg/kg bwt; 3 horses); and (3) the reproducibility of lobeline-stimulated hyperpnoea (5 horses; 2 doses of 0.20 mg/kg bwt lobeline, 15 min apart). All horses tolerated the lobeline-stimulated hyperpnoea well, although one always coughed or snorted at the onset. Mild tremor was noted following the highest dose in several horses. Apnoea of approximately 40 s was common after the hyperpnoea. Both tidal volume (VT) and frequency (fR) increased with lobeline dose. During peak hyperpnoea at a dose of 0.30 mg/kg bwt, peak inspired flow rate (PIF), peak expired flow rate (PEF) and minute ventilation (.VE) were mean ± s.e. 41 ± 5 l/s, 61 ± 10 l/s and 920 ± 99 l/min, respectively. The hyperpnoea also caused marked changes in arterial PaO2, PaCO2 and pHa at 90 s after lobeline (0.20 mg/kg bwt) administration (mean ± s.e. 146.0 ± 6.9 mmHg, 20.6 ± 0.8 mmHg and 7.707 ± 0.020, respectively) compared to at rest (mean ± s.e. 104.0 ± 4.0 mmHg, 50.6 ± 2.8 mmHg and 7.432 ± 0.012). Dynamic lung compliance (Cdyn) was unaltered by lobeline administration. The lobeline-induced hyperpnoea was highly reproducible, with no significant difference in any of the parameters during 2 stimulations 15 min apart. Lobeline induced highly reproducible responses without any apparent adverse effects and may be useful in the investigation of pulmonary function in healthy horses and those with airway disease. [less ▲]

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See detailQuantitative bacterial cultures and cytological examination of bronchoalveolar lavage specimens in the diagnosis of lower respiratory tract disease in dogs: a retrospective study of 48 cases.
Peeters, Dominique ULg; McKierman, B.; Weisiger, R. et al

in Journal of Veterinary Internal Medicine (2000), 14(5), 534-541

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective ... [more ▼]

Cytology and quantitative bacterial cultures of lower respiratory tract secretions are widely used in human medicine to differentiate airway infection from simple bacterial colonization. A retrospective study was conducted to determine the usefulness of quantitative aerobic cultures and Gram stain intracellular bacteria counts from bronchoalveolar lavage (BAL) specimens in dogs in diagnosing lower respiratory tract infection (LRTI) and to determine whether chronic bronchitis is associated with marked bacterial growth in dogs. The threshold determined to define clinically relevant bacterial growth was 1.7 x 10(3) colony-forming units per milliliter of BAL fluid. We used this threshold and found that diagnostic sensitivity and specificity were 86% and 100%, respectively. With a threshold for infection of >2 intracellular bacteria observed in any of 50 fields, microscopic examination of Gram stain BAL preparations had a sensitivity of 71% and a specificity of 97% in establishing LRTI. There was a high correlation between bacterial morphology on BAL Gram stain and bacterial cultures. Combining the results of intracellular bacteria counts from the BAL Gram stain with those from the quantitative cultures, the sensitivity in diagnosing LRTI was 87% and the specificity was 97%. BAL quantitative cultures as well as quantitating intracellular bacteria on Gram stain BAL cytology were revealed to be useful in identifying LRTI in dogs. Chronic bronchitis does not appear to be associated with marked bacterial growth in dogs. [less ▲]

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See detailPrivatisation d'entreprises publiques, économie de marché et transformation des systèmes juridiques étatiques
Thirion, Nicolas ULg

in Pyramides : Revue du Laboratoire d’Etudes et de Recherches en Administration Publique (2000), (2), 85-110

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See detailUse of stable isotope to delineate amphipod trophic status in Antarctic food webs
Nyssen, Fabienne ULg

in Polish Archives of Hydrobiology (2000), 47

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See detailNeurotoxicity Of The Putative Transmembrane Domain Of The Prion Protein
Haik, S.; Peyrin, Jm.; Lins, Laurence ULg et al

in Neurobiology of Disease (2000), 7(6), 644-56

It has been shown recently that the generation of an abnormal transmembrane form of the prion protein ((Ctm)PrP) is involved in the neurodegeneration process during inherited and infectious prion diseases ... [more ▼]

It has been shown recently that the generation of an abnormal transmembrane form of the prion protein ((Ctm)PrP) is involved in the neurodegeneration process during inherited and infectious prion diseases but a causative relationship has never been established. We wanted to know if and how the proposed transmembrane domain of PrP could induce neuronal dysfunction. Thus, we investigated the neurotoxic properties of two peptides whose sequences are encompassed within this domain. We show that PrP peptides 118-135 and 105-132 as well as an amidated more soluble peptide 105-132 induce the death of pure cortical neurons originating from normal and PrP knockout mice. This can be correlated with the high propensity of these peptides to insert stably into and to destabilize cell membranes. Through this study, we have identified a novel mechanism of neurotoxicity for PrP, which directly involves membrane perturbation; this mechanism is independent of fibril formation and probably corresponds to the effect of the transmembrane insertion of (Ctm)PrP. [less ▲]

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