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See detailprésentation de : Abbé Lhomond, De viris (les grands hommes de Rome), Latin/français, traduit et présenté par J. Gaillard, Paris, 1995
Rochette, Bruno ULg

in Bulletin de la Fédération des Professeurs de Grec et de Latin (1995), 99

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See detailIsolated Atherosclerotic Aneurysms of the Iliac Arteries
Desiron, Quentin ULg; Detry, Olivier ULg; Sakalihasan, Natzi ULg et al

in Annals of Vascular Surgery (1995), 9(Suppl), 62-6

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two ... [more ▼]

Atherosclerotic aneurysms limited to the iliac arteries are rare and entail a high risk of rupture. To evaluate the efficacy of prophylactic surgery, we retrospectively studied 15 patients (13 men and two women; mean age 69 years) treated for isolated iliac aneurysms in the Department of Cardiovascular Surgery at the University Hospital of Liege over a period of 18 years. They had a total of 25 aneurysms (20 common iliac and five internal iliac). Six patients were treated electively and nine on an emergency basis for rupture. Five of the emergency patients (33%) died in the early postoperative period (< 30 days); in each case the aneurysm had ruptured and an emergency operation was performed (55.5% mortality in the ruptured iliac aneurysm group). On the other hand, all patients treated electively survived. Our study is comparable to other recent series in the literature, which also reported a high incidence of rupture and death in emergency operations. Prophylactic elective surgery is recommended for iliac aneurysms. [less ▲]

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See detailResults of an Exclusion Technique for Treatment of Abdominal Aortic Aneurysm
Marnette, J.M.; CREEMERS, Etienne ULg; TROTTEUR, Geneviève ULg et al

in Cardiovascular Surgery (1995), 3(1), 26-9

An exclusion technique for the treatment of abdominal aortic aneurysm was used in six patients considered to be at high operative risk mainly because of chronic pulmonary disease. There were no deaths or ... [more ▼]

An exclusion technique for the treatment of abdominal aortic aneurysm was used in six patients considered to be at high operative risk mainly because of chronic pulmonary disease. There were no deaths or immediate major complications. Thrombosis of the aneurysm was achieved in four of the six patients. However, in three cases, repeated percutaneous embolization was required to produce thrombosis. One patient developed a secondary rupture of a persisting infrarenal sac resulting from a patent inferior mesenteric artery. This patient was successfully managed by ligature of the infrarenal portion of the abdominal aorta through a median laparotomy. This study emphasizes the limits and the risks of the exclusion technique. [less ▲]

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See detailMacroarthropod-habitat relationships in oak forests in South Belgium. 1. Environments and communities
Branquart, E.; Kime, R. D.; Dufrêne, Marc ULg et al

in Pedobiologia (1995), 39(3), 243-263

[No abstract available]

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See detailEn Belgique, diverses modalités de pâturage pour des taurillons avant finition à l'auge
Dufrasne, Isabelle ULg; Gielen, Marc ULg; Limbourg, Pierre et al

in Fourrages (1995), 141

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See detailLes allogreffes veineuses pour sauvetage des membres inférieurs: espoirs et réalité
VAN DAMME, Hendrik ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(10), 433-42

La veine saphène interne est le matériel de pontage de premier choix pour les revascularisations de membres au-dessous du pli de l'aine. Elle n'est néanmoins pas disponible chez près de 20 % des candidats ... [more ▼]

La veine saphène interne est le matériel de pontage de premier choix pour les revascularisations de membres au-dessous du pli de l'aine. Elle n'est néanmoins pas disponible chez près de 20 % des candidats à une chirurgie infra-inguinale, soit parce qu'elle a déjà été utilisée antérieurement, soit à cause de varicose ou d'un calibre trop petit. Ces dernières années ont vu apparaître dans la littérature un regain d'intérêt pour la veine saphène allologue, prélevée chez un donneur d'organes ou préparée à partir de segments de veine saphène strippée. Les auteurs en discutent les avantages théoriques et les modalités de conservation. Des travaux expérimentaux ont été suivis par des séries cliniques encore limitées en nombre et en temps de suivi. Les auteurs en discutent les résultats publiés. Une courte série (12 cas) dans notre département est décrite. Cette expérience limitée et une revue exhaustive de la littérature permettent de conclure que les allogreffes veineuses sont à réserver pour les sauvetages de jambes (lésions infrapoplitées) lorsque la veine autologue n'est pas disponible, en tant que solution de dernier recours. [less ▲]

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See detailApplication Of The Quasi-Static Mode Of The Drop Volume Technique To The Determination Of Fundamental Surfactant Properties
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Delhaye, Sylvie et al

in Journal of Colloid and Interface Science (1995), 174(2), 373-377

The quasi-static mode of the drop volume technique has been applied for determining the equilibrium surface tension-concentration (σe-c) curves of ionic (SDS, CTAB) zwitterionic (CHAPS), and nonionic ... [more ▼]

The quasi-static mode of the drop volume technique has been applied for determining the equilibrium surface tension-concentration (σe-c) curves of ionic (SDS, CTAB) zwitterionic (CHAPS), and nonionic (Triton X-100) surfactants. The experimental values have been fitted in two parts by the best polynomial and straight-line equations. Determination coefficients (R2) higher than 0.98 were achieved for all σe-c curves. The critical micelle concentration (CMC) and surface tension at the CMC have been calculated at the intersection point of the two fitted curves. The results conform with those found in the literature. The polynomial equation derivative at the CMC was used in the Gibbs equation to calculate the maximum surface excess concentration and the corresponding molecular area. The space required per molecule under saturation conditions is in agreement with the surfactant structures. A comparison with the Wilhelmy-plate method was also made. It is concluded that the quasi-static drop volume method provides accurate results and presents many practical advantages. [less ▲]

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See detailLa physiologie de la valvule mitrale
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 289-91

Faisant suite à une revue de l'anatomie de l'appareil mitral, les auteurs envisagent la physiologie de la valvule mitrale en étudiant les quatre phénomènes distincts que sont la contraction auriculaire ... [more ▼]

Faisant suite à une revue de l'anatomie de l'appareil mitral, les auteurs envisagent la physiologie de la valvule mitrale en étudiant les quatre phénomènes distincts que sont la contraction auriculaire, la dynamique de l'anneau, les mouvements de la valvule et la dynamique du flux mitral, ainsi que le jeu des muscles papillaires. Cette subdivision didactique ne doit pas estomper le fait que c'est l'intégration de ces phénomènes qui contribue à l'efficacité de la valvule. [less ▲]

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See detailGnawing induced by dopaminergic mobilzation : differential effects of direct and indirect dopamine agonists in mice
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1995), 273

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See detailRenouvellement de la couche cornée
Pierard, Gérald ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg

in Desquamation Adhesion (1995)

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See detailVariational Calculationof the Dynamic Third-Order Susceptibility of Water
Gabryl, Jean-René; Barbier, Christian ULg; Lemaire, Philippe et al

in Journal of Molecular Structure : Theochem (1995), 357

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See detailEffects of glucocorticoids and sympathomimetic agents on basal and insulin-stimulated glucose metabolism.
Paquot, Nicolas ULg; Schneiter, P.; Jequier, E. et al

in Clinical Physiology (1995), 15(3), 231-40

The mechanisms responsible for glucocorticoid-induced insulin resistance remain unclear. Glucocorticoids show several interactions with the sympatho-adrenal system which may contribute to this decrease in ... [more ▼]

The mechanisms responsible for glucocorticoid-induced insulin resistance remain unclear. Glucocorticoids show several interactions with the sympatho-adrenal system which may contribute to this decrease in insulin sensitivity: they enhance the synthesis and actions of catecholamines, but abolish insulin-induced activation of muscle sympathetic nerve activity. The present study was performed in order to investigate the effects of the interactions between glucocorticoids and the sympatho-adrenal system on insulin sensitivity. Basal and insulin-stimulated glucose metabolism was measured in healthy human subjects during four 2-h clamp studies as follows: control (C); after taking oral dexamethasone (2 mg daily) for 2 days (D); after taking oral ephedrine sulphate (40 mg daily) for 2 days (E); and after taking dexamethasone+ephedrine (D+E). Glucose uptake, production and oxidation were calculated from plasma 13C glucose and exhaled 13CO2 during constant tracer infusion of U-13C glucose. Basal glucose production, utilization and oxidation were similar in all four studies. During hyperinsulinaemia, glucose uptake was reduced by 51.5% with treatment D, by 25.9% with treatment E, and by 49.6% with D+E. Glucose oxidation was reduced by 54.0% with treatment D, by 24.0% with treatment E, and by 57.2% with D+E. Hepatic glucose production was completely suppressed in all four studies. It is concluded that both dexamethasone and ephedrine decrease insulin-mediated glucose uptake and oxidation. Co-administration of ephedrine does not suppress the glucocorticoid-induced alterations of glucose metabolism. This indicates that glucocorticoid-induced insulin resistance is not related to the inhibition of muscle sympathetic nerve activity. These results suggest instead that glucocorticoids and sympathomimetic agents may impair glucose metabolism by common actions. [less ▲]

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See detailModulation of the Clozapine Structure Increases Its Selectivity for the Dopamine D4 Receptor
Liégeois, Jean-François ULg; Bruhwyler, J.; Damas, Jacques ULg et al

in European Journal of Pharmacology (1995), 273(3), 1-3

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a ... [more ▼]

Clozapine has a more marked affinity for the recently cloned dopamine D4 receptor than for the dopamine D2 receptor. In the search for a selective ligand for the dopamine D4 receptor, useful as a pharmacological tool or as a potent atypical antipsychotic, a pyridobenzodiazepine derivative bioisoster of clozapine, JL 18, 8-methyl-6-(4-methyl-1-piperazinyl)-11H-pyrido [2,3-b][1,4]benzodiazepine, was found to be the most dopamine D4-selective ligand belonging to the diarylazepine class. Indeed, JL 18 binds to the dopamine D4 receptor with affinity up to 25 times superior to that for the dopamine D2 receptor and presents reduced affinities for other receptors. [less ▲]

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See detailInsulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
Malaisse, W. J.; Nadi, A. B.; Malaisse-Lagae, F. et al

in General Pharmacology (1995), 26(6), 1319-25

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial ... [more ▼]

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells. [less ▲]

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See detailDebate. Personal Experience and Research Experience : A Reflexive Account
Martiniello, Marco ULg; Ouali, Nouria; Choenni, C.

in Merger (1995), 3(2), 4-7

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See detailThe importance of liposomes as models and tools in the understanding of photosensitization mechanisms
Hoebeke, Maryse ULg

in Journal of Photochemistry and Photobiology B : Biology (1995), 28(3), 189-196

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in ... [more ▼]

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring <br />m vivo and they allow study of the influence of physieochemieal, photobioiogieal and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization of the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency. [less ▲]

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See detailLa fin du Mésolithique et le Néolithique au Proche-Orient
Tunca, Önhan ULg

in Le génie de l'Homme. Des origines à l'écriture (1995)

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See detailEffects of a new oral contraceptive containing an antimineralocorticoid progestogen, drospirenone, on the renin-aldosterone system, body weight, blood pressure, glucose tolerance, and lipid metabolism.
Oelkers, W.; Foidart, Jean-Michel ULg; Dombrovicz, N. et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(6), 1816-21

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a ... [more ▼]

Combined hormonal oral contraceptives (OCs) may lead to a mild rise in blood pressure and body weight. In rare instances, large increments in blood pressure are measured. We investigated the effect of a combination of ethinyl estradiol (EE) plus a progestogen with antimineralocorticoid, i.e. natriuretic, properties [Drospirenone (DRSP)] on body weight, blood pressure, the renin-aldosterone system, atrial natriuretic factor, plasma lipids, and glucose tolerance. It is anticipated that this will lead to the development of an OC that does not raise body weight or blood pressure. Four groups of 20 women each received 30 micrograms EE plus 3 mg DRSP (group A), 20 micrograms EE plus 3 mg DRSP (group B), 15 micrograms EE plus 3 mg DRSP (group C), and, as a control OC, 30 micrograms EE plus 150 micrograms levonorgestrel (Microgynon, Schering; group D) for 6 months. During the OC-free control cycles before and after treatment and throughout treatment, the target parameters were measured. Between the pretreatment cycle and the sixth treatment cycle, mean body weight fell by 0.8 to 1.7 kg in groups A, B, and C (P < 0.05 vs. D), whereas it rose by 0.7 kg in group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in groups A, B, and C (significant for A and C vs. D) and increased by 1-2 mm Hg in group D. Renin substrate rose equally in all groups (P < 0.05), whereas PRA and plasma aldosterone rose significantly only in the DRSP groups, presumably due to sodium loss. In the DRSP groups, high density lipoprotein cholesterol rose (P < 0.05), in contrast to group D. Low density lipoprotein cholesterol fell slightly (P > 0.05), whereas triglyceride levels showed a stronger increase in the DRSP groups (P < 0.05) than in group D. All groups attained good cycle control; group A had the best. Side-effects were minimal. To our knowledge, this is the first report on a combined OC that leads to a small decrease in body weight and blood pressure. It may be especially beneficial for women susceptible for a gain in weight and a rise in blood pressure. The potential of a new oral contraceptive (OC) containing drospirenone (DRSP) to avert the moderate increases in body weight and blood pressure often associated with use of existing combined OCs was investigated in a study of four groups of 20 German women each. Group A received 30 mcg of ethinyl estradiol (EE) and 3 mg of DRSP, Group B was administered 20 mcg of EE and 3 mg of DRSP, Group C received 15 mcg of EE and 3 mg of DRSP, and Group D was given a standard OC containing 30 mcg of EE and 150 mcg of levonorgestrel. Between the pretreatment cycle and the last (sixth) treatment cycle, mean body weight fell by 0.8-1.7 kg in Groups A, B, and C, but rose by 0.7 kg in Group D. Systolic and diastolic blood pressures fell by 1-4 mm Hg in Groups A, B, and C and rose by 1-2 mm Hg in Group D. Renin substrate rose equally in all four groups, while plasma renin activity, plasma aldosterone, and high density lipoprotein cholesterol rose significantly only in the three DRSP groups and serum triglyceride levels were significantly higher in Group D than in the three DRSP groups. Glucose tolerance increases were similar in all four groups. Finally, all groups--but especially Group A--experienced good cycle control and there were no serious side effects. These findings suggest that a combined OC containing DRSP may be especially beneficial for women who have a tendency to gain weight or experience a rise in blood pressure while taking OCs. [less ▲]

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See detailFundamentals of transformed skeletal muscle used for cardiac assistance. An overview
Radermacker, M. A.; Chachques, J. C.; Sluse, Francis ULg et al

in Research in Surgery (1995), 7

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See detailLocalization and transmembrane topology of a new member of the mitochondrial carrier family, the yeast RIM 2 gene product
Elmoualij, Benaïssa ULg; Duyckaerts, Claire ULg; Lamotte-Brasseur, J. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995)

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See detailInfluence of creep on the microstructure of Zn-Al-Cu alloys aged at 250°C
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Wegria, J.

in Physica Status Solidi A : Applied Research (1995), 152[2]

This paper is a continuation of a microstructural study of ZA alloys subjected to ageing at different temperatures with subsequent creep at 20 and 120 °C. it was already established that the samples aged ... [more ▼]

This paper is a continuation of a microstructural study of ZA alloys subjected to ageing at different temperatures with subsequent creep at 20 and 120 °C. it was already established that the samples aged for one week at 100 and 250 °C show the slowest creep rate. Furthermore, the resuits obtained afler ageing at 250 °C are better than those obtained after ageing at 100 °C. In order to explain more correctly these resuits, the microstructure is studied after ageing at 250 oc and subsequent creep at room temperature under pressure at 100 MPa and at 120 °c under pressure at 40 MPa, on test samples broken after the respective creep. [less ▲]

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See detailTHEORY OF THE THERMAL-CONDUCTIVITY OF RE AL-2 COMPOUNDS
Rassili, Ahmed ULg; Ausloos, Marcel ULg

in Journal of Magnetism & Magnetic Materials (1995), 147(3), 341-345

On the basis of the variational method for transport coefficients we have calculated the thermal conductivity of RE Al-2-like systems as a function of temperature. The low-temperature limit obeys ... [more ▼]

On the basis of the variational method for transport coefficients we have calculated the thermal conductivity of RE Al-2-like systems as a function of temperature. The low-temperature limit obeys Matthiessen's rule 1/kappa = 1/kappa(ph) + 1/kappa(s) + 1/kappa(imp) where the three components are the contributions arising from e(-)-phonon, e(-)-localized spin and e(-)-impurity interactions, respectively. The temperature dependence of each term has been calculated, as well as the superposition of all three. The influence of the physical parameters (spin value, Debye temperature, cut-off wave vector, Fermi energy, etc.) is shown. The theory is in good agreement with reported data for GdAl2. [less ▲]

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See detailDetection of Ground Movements on the Mt. Etna Volcano using the Global Positioning System
Bruyninx, Carine; Warnant, René ULg

in Acta Vulcanologica (1995), 7(1), 27-33

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See detailBehavior of interchromatin granules during the cell cycle.
Thiry, Marc ULg

in European Journal of Cell Biology (1995), 68(1), 14-24

We investigated at the ultrastructural level, by different cytochemical and immunocytological approaches, the behavior of interchromatin granules (IGs) during interphase and mitosis in two cell lines (HEp ... [more ▼]

We investigated at the ultrastructural level, by different cytochemical and immunocytological approaches, the behavior of interchromatin granules (IGs) during interphase and mitosis in two cell lines (HEp-2 and Ehrlich tumor cells). Identical results were found in all two cell types. In interphase cells, IGs group into irregular clusters of varying size. They are frequently associated with coiled bodies and homogeneous fibrillar bodies. Analysis of serial sections reveals that IG clusters occupy distinct regions within the nucleoplasm. During prophase, the aggregation of granules in these clusters gives rise to compact, spherical, granular structures. These disperse in the mitotic cytoplasm at the breakdown of the nuclear envelope. At early telophase, some of them come into close contact with the periphery of reforming nuclei. IG clusters reappear in the daughter nuclei only after the chromosomes have decondensed during late telophase. Concomitantly, the cytoplasmic granular structures disappear. During the cell cycle, IG are silver-stainable and EDTA-positive. They are also constantly labeled by the polyadenylate nucleotidyl transferase-immunogold technique for detecting RNA. These results support the view that IGs persist throughout the whole cell cycle. [less ▲]

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See detailAnalysis of learning tasks proposed within a volleyball teaching unit in secondary education. Comparison between two teachers differentiated by their expertise
Cloes, Marc ULg; Lapierre, Annick; Piéron, Maurice

in International VolleyTech (1995), 4

School physical education focussed on the harmonious development of the individual's various components - namely his motor, cognitive, affective and social dimensions. Within the French-speaking Community ... [more ▼]

School physical education focussed on the harmonious development of the individual's various components - namely his motor, cognitive, affective and social dimensions. Within the French-speaking Community of Belgium, as in many other regions in the world, the practive of voleyball comes within the activities proposed in the physical education programme of secondary education. The analysis of activites put forward by physical education teachers shows that volayball is the most practised collective sport in secondary education... [less ▲]

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See detail- Establishment of normal and transformed root cultures of Artemisia annua L. for artemisinin production.
Jaziri, M.; Shimomura, K.; Yoshimatsu, K. et al

in Journal of Plant Physiology (1995), 145(1-2), 175-177

Transformed cultures of Artemisia annua L. (Asteraceae) were established by the co-culture method using leaf segments of A. annua and Agrobacterium rhizogenes NCIB 8196 or MAFF 03-01724. The hairy root ... [more ▼]

Transformed cultures of Artemisia annua L. (Asteraceae) were established by the co-culture method using leaf segments of A. annua and Agrobacterium rhizogenes NCIB 8196 or MAFF 03-01724. The hairy root clones thus obtained grew vigorously on hormone-free medium, showing the typical transformed morphology. The genetic transformation of the root was proved by the opine assay. Normal root and shoot cultures were also established. A highly specific and sensitive enzyme-linked immuno-sorbent assay (ELISA) method was used for the detection and semi-quantitative determination of artemisinin and structurally related compounds in these cultures. The presence of artemisinin was confirmed by gas chromatography coupled to mass spectrometry (GC-MS) analysis. The hairy roots cultured in the dark produced no detectable level of artemisinin as shown by the adventitious shoots cultured under light conditions. The ELISA analysis of the green hairy roots cultured in liquid medium under a 16 h light/day photoperiod showed the existence of compound(s) structurally related to artemisinin, though normal and hairy roots cultured in the dark give no detectable levels of immuno-signal. [less ▲]

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See detailExpression of the monomeric 67-kd laminin-binding protein in human lymphomas as defined by MLuC5 monoclonal antibody and paraffin section immunohistochemistry.
Carbone, A.; Gloghini, A.; Colombatti, A. et al

in Human Pathology (1995), 26(5), 541-6

Interactions between cancer cells and laminin, a major component of basement membranes, are mediated through a large variety of cell surface proteins designated as laminin receptors. Among the above ... [more ▼]

Interactions between cancer cells and laminin, a major component of basement membranes, are mediated through a large variety of cell surface proteins designated as laminin receptors. Among the above proteins, a 67-kd monomeric high affinity laminin receptor (67 LR) has long been suspected to be involved in tumor progression. In this study we wished to establish whether the 67 LR molecule is detectable on tumor cells of Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NHLs), to define its pattern of expression, and to assess the potential utility of 67 LR in differentiating these pathological entities. Morphological and immunohistological studies were performed on 85 specimens of HD and a series of 334 NHL specimens, including anaplastic large cell (ALC) (CD30-positive) lymphomas (73 specimens). For immunohistochemical assessment of the 67 LR we used the monoclonal antibody (MoAb) MLuC5 directed against the 67-kd laminin receptor on paraffin-embedded sections. Reed-Sternberg cells reacted with MLuC5 MoAb in four of 85 (4.7%) HD specimens. Among the NHL specimens, a MLuC5-positive reaction was expressed in 3.3% of B-cell lymphomas. They all belonged to the high grade subtypes. On the other hand, a MLuC5-positive reaction was detected in none of the T-cell lymphomas tested. In contrast to the results obtained with the other NHLs, in 30.2% of ALC (CD30-positive) lymphoma specimens, tumor cells reacted with MLuC5 MoAb. MLuC5-expressing ALC (CD30-positive) lymphoma cells were of either T-cell (six of 17 specimens), B-cell (three of 25 specimens), or undetermined phenotype (10 of 31 specimens). Our investigation has shown that 67 LR as shown by MLuC5 MoAb is detectable only in neoplastic cells of a fraction of ALC (CD30-positive) lymphomas and small subsets of B-cell high grade NHLs and HD. The restricted expression of the 67 LR molecule to ALC (CD30-positive) lymphomas provides a potential tool for the phenotypic separation of this pathological entity from HD and other lymphomas. Whether the detection of the 67 LR expression in these lymphoma subsets may be related to the aggressiveness of the disease remains to be ascertained. [less ▲]

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See detailAnalyse critique de l'utilisation d'un appareil isocinétique
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Journal de Traumatologie du Sport (1995), 12

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See detailHuman germinal center CD4+CD57+ T cells act differently on B cells than do classical T-helper cells.
Bouzahzah, F.; Bosseloir, A.; Heinen, Ernst ULg et al

in Developmental Immunology (1995), 4(3), 189-97

We have isolated two subtypes of helper T cells from human tonsils: CD4+CD57+ cells, mostly located in the germinal center (GC), and CD4+CD57- cells, distributed through the interfollicular areas but also ... [more ▼]

We have isolated two subtypes of helper T cells from human tonsils: CD4+CD57+ cells, mostly located in the germinal center (GC), and CD4+CD57- cells, distributed through the interfollicular areas but also present in the GC. In a functional study, we have compared the capacities of these T-cell subtypes to stimulate B cells in cocultures. In order to block T-cell proliferation while maintaining their activation level, we pretreated isolated T cells with mitomycin C prior to culture in the presence of B cells and added polyclonal activators such as PHA and Con A, combined or not with IL-2. Contrary to CD4+ CD57- cells, CD4+CD57+ cells did not markedly enhance B-cell proliferation. Even when sIgD.B cells typical of germinal center cells were tested, the CD4+CD57+ cells had no significant effect. This is in accordance with the location of these cells: They mainly occupy the light zones of the GC where few B cells divide. Even when added to preactivated, actively proliferating cells, CD4+CD57 cells failed to modulate B-cell multiplication. On the supernatants of B-cell-T-cell cocultures, we examined by the ELISA technique the effect of T cells on Ig synthesis. Contrary to CD57+ T cells, whose effect was strong, CD57- T cells weakly stimulated Ig synthesis. More IgM than IgG was generally found. Because CD57 antigen is a typical marker of natural killer cells, we tested the cytolytic activity of tonsillar CD4+CD57+ cells on K562 target cells. Unlike NK cells, neither CD4+CD57+ nor CD4+CD57- cells exhibit any cytotoxicity. Thus, germinal center CD4+CD57+ cells are not cytolytic and do not strongly stimulate either B-cell proliferation or Ig secretion. CD4+CD57- cells, however, enhance B-cell proliferation and differentiation, thus acting like the classical helper cells of the T-dependent areas. [less ▲]

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See detailNotice sur Marcel Migeotte
Biémont, Emile ULg

in Annuaire de l'Académie Royale de Belgique (1995)

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See detailSuccessful abdominal aortic aneurysm resection in long-term survivors of cardiac transplantation.
Defraigne, Jean-Olivier ULg; SakalihasanN, Natzi ULg; DEMOULIN, Julie ULg et al

in Cardiovascular Surgery (1995), 3(3), 321-4

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm ... [more ▼]

With the improvement of survival rates following cardiac transplantation, the probability of recipients developing extracardiac disease is increased. Three cases are reported of abdominal aortic aneurysm successfully operated on in cardiac allograft recipients 1 to 4 years after transplantation. Indications for transplantation were valvular, idiopathic and ischaemic cardiomyopathy. Post-transplant hypertension and hyperlipidaemia may have played a role in the rapid growth of the aneurysms. Cardiac function and the incidence of graft atherosclerosis were assessed before surgery by coronary angiography. All three patients were discharged from hospital. Abdominal aortic aneurysm resection may be a safe procedure in cardiac transplant patients. In view of the rapid increase in the size of the aneurysms in transplanted patients, careful screening should be performed during follow-up. [less ▲]

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See detailAssessment of lipoxygenase activity in seed extracts from 35 plant species
Fauconnier, Marie-Laure ULg; Vanzeveren, E.; Marlier, Michel et al

in Grasas y Aceites (1995), 46(1), 6-10

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several ... [more ▼]

Lipoxyganase activity in 35 seed extracts was determined an the basis of hydroperoxide synthesis using linoleic acid as substrate. The results referring to the extracted protein content show that several species of Vigna (V. unguiculata, V. radiata and V. mungo) and one of Trifolium exhibit stronger lipoxygenase activity than soybean enzyme extracts. The pH-activity relationship was also established for 4 very active samples. GCMS analysis revealed equal amounts of 9- and 13 hydroperoxides of linoleic acid In these seed extracts, indicating no enzyme positional specificity. [less ▲]

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See detailAvoided resonance overlapping beyond the energy independent formalism. I. Vibrational predissociation
Desouter, Michèle ULg; Liévin, Jacques; Brems, Vincent

in Journal of Chemical Physics (1995), 103

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See detailThe quark propagator from the Dyson-Schwinger equations: (I). The chiral solution
Cudell, Jean-René ULg; Gentles, A. J.; Ross, D. A.

in Nuclear Physics B (1995), 440

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See detailCeci est mon corps
Spinoy, Erik ULg

in Yang : Tijdschrift voor Literatuur en Kommunikatie (1995), 31(5),

This is a special issue on the body in literature and art.

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See detailDynamic generalized linear models and repeated measurements
Lindsey, James ULg; Lambert, Philippe ULg

in Journal of Statistical Planning & Inference (1995), 47

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count ... [more ▼]

The dynamic generalized linear model for non-normal data is extended for use in repeated measurements, when series of observations are available for more than one individual. Examples are given for count and duration data. [less ▲]

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See detailStreptomyces K15 active-site serine DD-transpeptidase: specificity profile for peptide, thiol ester and ester carbonyl donors and pathways of the transfer reactions.
Grandchamps, Jacqueline; Nguyen-Distèche, Martine ULg; Damblon, Christian ULg et al

in Biochemical Journal (1995), 307(Pt 2), 335-339

The Streptomyces K15 transferase is a penicillin-binding protein presumed to be involved in bacterial wall peptidoglycan crosslinking. It catalyses cleavage of the peptide, thiol ester or ester bond of ... [more ▼]

The Streptomyces K15 transferase is a penicillin-binding protein presumed to be involved in bacterial wall peptidoglycan crosslinking. It catalyses cleavage of the peptide, thiol ester or ester bond of carbonyl donors Z-R1-CONH-CHR2-COX-CHR3-COO- (where X is NH, S or O) and transfers the electrophilic group Z-R1-CONH-CHR2-CO to amino acceptors via an acyl-enzyme intermediate. Kinetic data suggest that the amino acceptor behaves as a simple alternative nucleophile at the level of the acyl-enzyme in the case of thiol ester and ester donors, and that it binds to the enzyme.carbonyl donor Michaelis complex and influences the rate of enzyme acylation by the carbonyl donor in the case of amide donors. Depending on the nature of the scissile bond, the enzyme has different requirements for substituents at positions R1, R2 and R3. [less ▲]

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See detailContribution de la chimie macromoléculaire à l'élaboration de matériaux colloïdaux et microparticulaires destinés à la vectorisation de médicaments
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Innovation et Technologies en Biologie et en Médecine (1995), 16

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological ... [more ▼]

Various colloidal and microparticular vector have been tailored during the last few years in order to promote the transport , the protection and the orientation of the drug towards its pharmacological target. The aim of the paper is to give some insight about the contribution of the macromolecular engineering for the development of two vectors : microparticles of a control biodegradation rate designed for the chemoembolization of hepatocarcinoma , amphiphile copolymeric micelles able to transport drug within the targeted cells. Starting from a synthetic polymer : polylactide, degradation rate caracteristics , and functionalities can be tailored for the intended applications. One of the major problems , and largely underestimated in the past , for the successfull design of polymeric carrier is to take into account the interaction of proteins with polymer surfaces. [less ▲]

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See detailAbility of Bronchodilators to Prevent Bovine Experimental Respiratory Distress
Genicot, Bruno; Lambert, Philippe ULg; Votion, Dominique ULg et al

in Veterinary Research (1995), 26(4), 276-283

This cross-over trial involving 6 Blue Belgian double-muscled calves aimed to investigate whether ipratropium bromide inhaled alone or in combination with clenbuterol hydrochloride could prevent the ... [more ▼]

This cross-over trial involving 6 Blue Belgian double-muscled calves aimed to investigate whether ipratropium bromide inhaled alone or in combination with clenbuterol hydrochloride could prevent the dramatic clinical and pulmonary disturbances that are observed during an experimentally induced bronchoconstriction. Inhaled bronchodilators significantly influenced the clinical and functional responses of bovines subjected to a 5-hydroxytryptamine perfusion. However, despite a mean (standard error) wash-out period of 11.2 (3.1) and 7.5 (0.9) d after the 1st and the 2nd one-day challenges, respectively, first-order carry-over effects (ie those remaining from the previous treatment), effects of the period during which the treatment was allocated and interaction effects did not allow a definitive interpretation of overall treatment differences. [less ▲]

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See detailFollicular Dendritic Cells: Origin and Function
Heinen, Ernst ULg; Bosseloir, A.; Bouzahzah, F.

in Current Topics in Microbiology and Immunology (1995), 201

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See detailL'hypothyroidie subclinique.
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1995), 50(4), 171-4

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie ... [more ▼]

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie affectant surtout les personnes âgées est justifié par l'existence de troubles du bilan lipidique, de goitres et de perturbations neuropsychologiques. Celui-ci repose sur l'administration de lévothyroxine à dose minimale pour normaliser la TSH [less ▲]

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See detailThiamine Deficiency--Induced Partial Necrosis and Mitochondrial Uncoupling in Neuroblastoma Cells Are Rapidly Reversed by Addition of Thiamine
Bettendorff, Lucien ULg; Sluse, Francis ULg; Goessens, Guy ULg et al

in Journal of Neurochemistry (1995), 65(5), 2178-2184

Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i.e., the ... [more ▼]

Culture of neuroblastoma cells in a medium of low-thiamine concentration (6 nM) and in the presence of the transport inhibitor amprolium leads to the appearance of overt signs of necrosis; i.e., the chromatin condenses in dark patches, the oxygen consumption decreases, mitochondria are uncoupled, and their cristae are disorganized. Glutamate formed from glutamine is no longer oxidized and accumulates, suggesting that the thiamine diphosphate-dependent alpha-ketoglutarate dehydrogenase activity is impaired. When thiamine (10 microM) is added to the cells, the O2 consumption increases, respiratory control is restored, and normal cell and mitochondrial morphology is recovered within 1 h. Succinate, which is oxidized via the thiamine diphosphate-independent succinate dehydrogenase, is also able to restore a normal O2 consumption (with respiratory control) in digitonin-permeabilized thiamine-deficient cells. Our results therefore suggest that the slowing of the citric acid cycle is the main cause of the biochemical lesion induced by thiamine deficiency as observed in Wernicke's encephalopathy. [less ▲]

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See detailCabergoline in prolactinomen.
Abs, R.; Verhaert, G.; Demez, Pierre ULg et al

in Tijdschrift voor Geneeskunde (1995), 51

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See detailA new analysis of the OH radical spectrum from solar infrared observations.
Mélen, F.; Sauval, A. J.; Grevesse, Nicolas ULg et al

in Journal of Molecular Spectroscopy (1995), 174

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See detailLes confraternités de l'abbaye de Stavelot-Malmedy
George, Philippe ULg

in Bulletin de la Commission Royale d'Histoire (1995), CLXI

réseau de fraternités de Stavelot-Malmdy mis en parallèle avec tous les échanges humains observés dans toutes les sources

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See detailVictor Hugo, "Comme dans les étangs..." : Correction d'un exercice d'analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1995), 27

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See detailEffects of infused sodium lactate on glucose and energy metabolism in healthy humans.
Paquot, Nicolas ULg; Schneiter, P.; Cayeux, M. C. et al

in Diabètes & Métabolism (1995), 21(5), 345-52

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg ... [more ▼]

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity. [less ▲]

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See detailPrediction Of The Antigenic Sites Of The Cystic-Fibrosis Transmembrane Conductance Regulator Protein By Molecular Modeling
Gallet, X.; Benhabiles, N.; Lewin, M. et al

in Protein Engineering (1995), 8(8), 829-34

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and ... [more ▼]

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and valuable antibodies have been raised [Muller et al. (1990) J. Gen. Virol., 71, 2709-2717]. We have improved the modelling approach to allow us to predict epitopes from the primary sequences of the cystic fibrosis transmembrane conductance regulator. The procedure involves searching for fragments of primary sequences likely to make amphipathic secondary structures, which are hydrophilic enough to be at the surface of the folded protein and thus accessible to antibodies. Amphipathic helices were predicted using the methods of Berzofsky, Eisenberg and Jahnig. Their hydrophobic-hydrophilic interface was calculated and drawn, and used to predict the orientation of the helices at the surface of the native protein. Amino acids involved in turns were selected using the algorithm of Eisenberg. Tertiary structures were calculated using 'FOLDING', a software developed by R. Brasseur for the prediction of small protein structures [Brasseur (1995) J. Mol. Graphics, in press]. We selected sequences that folded as turns with at least five protruding polar residues. One important property of antibodies is selectivity. To optimize the selectivity of the raised antibodies, each sequence was screened for similarity (FASTA) to the protein sequence from several databanks. Ubiquitous sequences were discarded. This approach led to the identification of 13 potential epitopes in the cystic fibrosis transmembrane conductance regulator: seven helices and six loops. [less ▲]

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See detailClinical neurophysiology and neurotransmitters
MAERTENS DE NOORDHOUT, Alain ULg; Wang, Wei; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1995), 15(4), 301-9

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional ... [more ▼]

Clinical neurophysiology allows non-invasive assessment of neurotransmitter function in various regions of the central and peripheral nervous system. In this review, we describe examples of functional evaluation of neurotransmission at the neuromuscular junction, in some spinal interneurons and intracortical circuits as well as evaluation of pharmacological modulation of some electrophysiological tests. These investigations are carried out to help our understanding of the pathophysiology of brain diseases. Finally, we discuss possible relationships between electrophysiological tests (evoked/event-related potentials and exteroceptive suppression of temporalis muscle activity) and neurotransmitter function in headache. [less ▲]

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See detailEvaluacion del comportamiento agressivo en ninos preescolares
Born, Michel ULg; Egido, A.; Pire, B.

in Revista Galega de Psicopedagogia (1995), 12(8), 149-165

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See detailLa classification fonctionnelle des dysfonctions de la valvule mitrale selon Carpentier
RADERMECKER, Marc ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1995), 50(7), 292-4

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une ... [more ▼]

Pour aborder le traitement chirurgical de la valvule mitrale autrement, c'est-à-dire par une réparation valvulaire comme alternative raisonnable au remplacement sytématique, il faut recourir à une classfication fonctionnelle des dysfonctions mitrales. Cette classification, établie par Carpentier (1, 2) regroupe les dysfonctions valvulaire mitrales en trois rubriques : a) le type caractérisé par des mouvements valvulaires normaux, b) le type 2, équivalent au prolapsus valvulaire, c) le type 3, correspondant à la restriction des mouvements valvulaires. Cette approche nouvelle postule, en outre, qu'une affection valvulaire n'est parfaitement définie que lorsqu'on en connaît l'étiologie, les lésions et les dysfonctions. L'utilisation de cette méthode analytique (qui a l'avantage de la simplicité et de la clarté) permet au chirurgien de réparer la valvule mitrale en adaptant à chaque dysfonction une correction appropriée et, par l'application de règles, d'obtenir des résultats reproductibles (3-6). [less ▲]

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See detailBiological activity and immunological reactivity of human prolactin mutants
Rhee, Harrison K; Sun, Zhenyu; Kim, Steve S et al

in Endocrinology (1995), 136(11), 4990-5

We examined the biological activity and immunological reactivity of four mutants of human PRL. Two were mutants that changed the ability of human PRL to inhibit rat PRL storage when transfected into a rat ... [more ▼]

We examined the biological activity and immunological reactivity of four mutants of human PRL. Two were mutants that changed the ability of human PRL to inhibit rat PRL storage when transfected into a rat pituitary cell line:mutations S34A and N31T. Two mutations were in regions of PRL that are highly conserved. One, des(3-11)-PRL, removed the N-terminal cystine loop that most PRLs, except those from certain fish, have, and no GHs have. The other, S90A, mutated a serine that is present in all PRLs but those from some fish and in all GHs. The immunological properties of des(3-11)-PRL were reduced 10-fold compared to those of wildtype human PRL in a RIA using NIH antihuman PRL-3, AFP C11580; the others were similar to those of wild-type PRL. The biological activity of des(3-11)-PRL was the most affected; activity was reduced about 8-fold compared to that of wild-type PRL in the Nb2 cell assay. The activities of the others were similar to that of the wild type. Serine 90 may be partially buried by loops connecting the alpha-helixes. The mutation of serine 90 did not affect the stability of the molecule in vitro, determined by comparing the red shift in tryptophan fluorescence that occurs with increasing concentrations of urea in S90A and wild-type PRL. The activity of S34A and N31T mutations indicates there is no correlation between biological activity and ability to affect storage. The N-terminal cystine loop may be conserved because it is needed for biological activity, but the conservation of serine 90 in GH and PRL must be determined by other properties, such as spacial requirements. [less ▲]

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See detailThe Dissociative Ionization of C2H2. The C+, C2+ and CH2+ Dissociation Channels. The Vinylidene Ion as a Transient?
Locht, Robert ULg; Davister, M.

in Chemical Physics (1995), 195

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic ... [more ▼]

The dissociative electroionization of C2H2 has been investigated in the C+, C2+ and CH2+ dissociation channels. Both the translational energy and the appearance energies have been measured. The kinetic energy versus appearance energy diagrams related to these species are discussed in detail and dissociation mechanisms are proposed for all observed onset energies. For the three ionic species, the dissociation pathways leading to the fragmentation of C2H2+ into C+, C2+ and CH2+ successively have to run very likely over an isomerization mechanism of the molecular ion. The isomeric vinylidene structure could be the most probable intermediate. [less ▲]

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See detailExploration biologique actuelle du métabolisme du fer
Charlier, Corinne ULg; Plomteux, Guy ULg

in Revue de la Médecine Générale (1995), 123

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See detailGlucose handling, diabetes and ageing.
Paolisso, G.; Scheen, André ULg; Lefebvre, Pierre ULg

in Hormone Research (1995), 43(1-3), 52-7

The relationship between ageing and glucose homeostasis is still an open debate. In fact, the mechanisms by which glucose metabolism is progressively impaired with increasing age are not completely ... [more ▼]

The relationship between ageing and glucose homeostasis is still an open debate. In fact, the mechanisms by which glucose metabolism is progressively impaired with increasing age are not completely understood. In the present report we have reviewed the possible mechanisms (impaired insulin secretion and action, role of the environmental factors) which may lead to the impairment in glucose handling associated with ageing. We also point out that not all aged subjects are glucose intolerant; in fact, it has been suggested that only those aged subjects who present more than one pathological finding do in fact develop impaired glucose handling. [less ▲]

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See detailEmergence of the ZNF91 Kruppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea
Bellefroid, Eric J.; Marine, Jean-Christophe; Matera, A Gregory et al

in Proceedings of the National Academy of Sciences of the United States of America (1995), 92(23), 10757-61

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the ... [more ▼]

The ZNF91 gene family, a subset of the Kruppel-associated box (KRAB)-containing group of zinc finger genes, comprises more than 40 loci; most reside on human chromosome 19p12-p13.1. We have examined the emergence and evolutionary conservation of the ZNF91 family. ZNF91 family members were detected in all species of great apes, gibbons, Old World monkeys, and New World monkeys examined but were not found in prosimians or rodents. In each species containing the ZNF91 family, the genes were clustered at one major site, on the chromosome(s) syntenic to human chromosome 19. To identify a putative "founder" gene, > 20 murine KRAB-containing zinc finger protein (ZFP) cDNAs were randomly cloned, but none showed sequence similarity to the ZNF91 genes. These observations suggest that the ZNF91 gene cluster is a derived character specific to Anthropoidea, resulting from a duplication and amplification event some 55 million years ago in the common ancestor of simians. Although the ZNF91 gene cluster is present in all simian species, the sequences of the human ZNF91 gene that confer DNA-binding specificity were conserved only in great apes, suggesting that there is not a high selective pressure to maintain the DNA targets of these proteins during evolution. [less ▲]

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See detailThe appearance energy of C2H+ from C2H2 revisited. A Photoion-Photoelectron Coincidence Spectroscopic Determination.
Servais, Christian ULg; Locht, Robert ULg

in Chemical Physics Letters (1995), 236

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been ... [more ▼]

The dissociative ionization of C2H2 in the C2H+-producing channel has been reconsidered. The photoion-photoelectron coincidence (PIPECO) technique has been used. The C2H+/e coincidence rate has been recorded between 16.2 and 21.2 eV. The lowest appearance energy determined for C2H+ is 17.35+/-0.04 eV. A second appearance energy is measured at 18.40+/-0.04 eV. At both energies ethynyl ions are produced through a predissociation mechanism at the expense of the C2H2+(A2Ag) state at 17.35 eV and C2H2+(B2Sigma+/g) at 18.40 eV. These results are in good agreement with the most recent TPIPECO experiments and dissociative electroionization results. This comparison leads to the exclusion of any contribution of autoionization phenomena to the C2H+ ion production between 16.2 and 21.2 eV. Investigations of C2H+ through the ion-pair formation channel (and dissociative electron attachment producing C2H- and H-) in C2H2 are reported and its contribution to C2H+ ion production below 17.3 eV must be discarded. [less ▲]

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See detailGrowth hormone response to apomorphine in panic disorder: comparison with major depression and normal controls.
Pichot, W.; Hansenne, Michel ULg; Gonzalez Moreno, A. et al

in European Archives of Psychiatry & Clinical Neuroscience (1995), 245(6), 306-8

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 ... [more ▼]

Several lines of evidence suggest that dopamine might be involved in anxiety states. In the present study we assessed the growth hormone (GH) response to 0.5 mg apomorphine (a dopaminergic agonist) in 10 male drug-free inpatients meeting Research Diagnostic Criteria for panic disorder who were compared with 10 male major depressive inpatients and 10 male normal controls. The three groups differed significantly in the GH peak response (mean +/- SD): 27.8 +/- 12.5 ng/ml in panics, 5.4 +/- 4.0 ng/ml in major depressives, and 25.8 +/- 11.3 ng/ml in normal controls (F(2,27) = 15.3; P = 0.00003). Although there were significant differences between panics and major depressives (P = 0.00004), and between major depressives and controls (P = 0.00004), panics did not significantly differ from controls. These results do not support the hypothesis of an overlap between panic and affective disorders, and suggest that the hypothalamo-GH-somatomedin axis could be intact in panic disorder. [less ▲]

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See detailA comparative study of quantitative shape analysis techniques in sedimentology
Pirard, Eric ULg; Hoyez, Bernard

in Zentralblatt für Geologie und Paläontologie. Teil I, Allgemeine, Angewandte, Regionale und Historische Geologie (1995), 1(H11/12), 1061-1066

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See detailInteresting Lines in the Infrared Solar Spectrum. II. Unblended Lines between 1.0 and 1.8µm
Ramsauer, J.; Solanki, S. K.; Biémont, Emile ULg

in Astronomy and Astrophysics. Supplement Series (1995), 113

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See detailOxygen transfert during Bacillus subtilis fermentation. Influence of lipopeptide production and an oxygen vector.
Hbid, Ch; Jacques, Ph.; Meurice, E. et al

in Archives Internationales de Physiologie et de Biochimie (1995), 103(B44),

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See detailScreening for in vitro Antifungal Activities of some Indole Alkaloids
Quetin-Leclercq, J.; Favel, A.; Balansard, G. et al

in Planta Medica (1995), 61

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta ... [more ▼]

Thirty indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts and dermatophytes. Our results indicate that the most active compounds possess a beta-carboline skeleton and that the presence of a 3,4 double bond enhances the activity. Our results also show that antifungal activities are not linked to the cytotoxic, antimicrobial or antiparsitic properties. [less ▲]

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See detailGrowth hormone-binding protein (GHBP) binds prolactine in cattle plasma
Massart, Serge; Ban, Anna-Maria; Renaville, Robert ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1995), 103

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See detailDepistage des neoplasies endocriniennes multiples de type 1 (NEM 1). Reflexion du Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1).
Cougard, P.; Calender, A.; Carnaille, B. et al

in Annales de Chirurgie (1995), 49(6), 500-506

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1 ... [more ▼]

The "Groupe d'Etude des Neoplasies Endocriniennes Multiples de type 1 (GENEM 1)" is a French group involved in a comprehensive multicentre study of Multiple Endocrine Neoplasia type 1 syndrome (NEM 1). The objectives of this group are to define diagnostic and therapeutic protocols and to carry out genetic research on NEM1. The first aim of physicians is to recognize the syndrome and to determine the appropriate screening especially into two circumstances: 1 degree In case of isolated and sporadic glandular disease -i-e-parathyroid glands, endocrine pancreas, antehypophysis, adrenal glands and neuroendocrine tumors? 2 degrees In case of very high probability of NEM 1 syndrome? This paper answers these two questions, based on the analysis of the first 150 cases collected by the GENEM 1. [less ▲]

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See detailUn autre regard sur les atlas de France et de Belgique.
Vansteenwegen, Christian; Dufrêne, Marc ULg; Lebrun, Philippe

in AVES (1995), 31

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See detailLa climatologie comme facteur modifiant du projet urbain
Dupagne, Albert ULg; Leclercq, Pierre ULg

in Publications de l'Association Internationale de Climatologie (1995), 8

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See detailProposition Of A 3-Dimensional Representation Of The Constitutive Protein Of The Hepatitis-B Surface-Antigen Particles
Sonveaux, N.; Ruysschaert, Jm.; Brasseur, Robert ULg

in Journal of Protein Chemistry (1995), 14(6), 477-86

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle ... [more ▼]

Hepatitis B surface antigen particles are composed of the major viral envelope protein, the S protein, embedded into a lipid shell. The description of the folding of this protein within the particle membrane could provide helpful information for replacing surface-exposed protein domains by foreign sequences without destabilizing the particle structure. Since the crystallization of the protein in its lipid environment remains inaccessible in the near future, alternative approaches had to be envisaged. We combine here the available experimental structural and topological data with a conformational procedure to identify membrane-associated domains of the HBsAg protein and to propose a three-dimensional description of their assembly within the particle membrane. The proposed protein structure is composed of four membrane-spanning helices and an amphipatic helix located on the inner surface membrane. The transmembrane helices are assembled into a highly hydrophobic complex in which no access to the water environment is allowed. The approach could be extended to other membrane-associated proteins. [less ▲]

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See detailPerformance of Belgian hospitals: a frontier approach
Fecher-Bourgeois, Fabienne ULg; Bosmans, Nathalie

in Health Economics (1995), 4,5(Sep-oct 1995), 389-397

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See detail24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J.; Scheen, André ULg; Leproult, R. et al

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

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See detailEtude du miveau de contamination par les PCBs et les pesticides organochlorés de loutres (Lutra lutra) et l'anguilles (Anguilla anguilla) issues de zones humides de l'oeust de la France
Tans, Michael; Hugla, Jean Louis; Libois, Roland ULg et al

in Cahiers d'Ethologie (1995), 15(2-3-4), 321-324

Organochlorinated pesticides and PCBs were identified in 32 otter carcasses (road casualties) found in the wetlands of western France. The contamination levels are relatively low compared to those found ... [more ▼]

Organochlorinated pesticides and PCBs were identified in 32 otter carcasses (road casualties) found in the wetlands of western France. The contamination levels are relatively low compared to those found in other otter European populations. As eel is the main prey of otters in that area, samples of that fish from the Marais poitevin were analysed too. They also show a low level of contamination by these compounds, their PCB congener pattern being different. [less ▲]

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See detailConnections and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Costruzioni Metalliche (1995), n°4

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailA experiência Pedagógica «Renovação do Ensino Elementar - Desenvolvimento Corporal das Crianças dos 2,5 Anos aos 12 Anos»
Piéron, Maurice; Cloes, Marc ULg; Delfosse, Catherine et al

in Boletim Sociedade Portuguesa de Educação Física (1995), 12(2), 31-58

This paper presents the methodology and main results of a research program aiming to identify the effect of a daily physical education project implemented in the French speaking part of Belgium.

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See detailIntérêt du calcul du rapport Trough/Peak (effet en fin de dose/effet maximum) lors d'un traitement antihypertenseur
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Médecine et Hygiène (1995), 53

Un rapport entre l'effet antihypertenseur résiduel (à la fin de l'intervalle entre deux prises) et l'effet au pic d'efficacité (TroughlPeak) constitue un index arithmétique utile pour apprécier l ... [more ▼]

Un rapport entre l'effet antihypertenseur résiduel (à la fin de l'intervalle entre deux prises) et l'effet au pic d'efficacité (TroughlPeak) constitue un index arithmétique utile pour apprécier l'efficacité antihypertensive pour la fréquence d'administration proposée après soustraction de l'effet placebo. Un rapport inférieur à 50% indique que la molécule doit être administrée soit à posologie plus élevée, soit plus fréquemment. A l'inverse, un rapport approchant les 100% indique que l'effet antihypertenseur est maintenu de façon homogène pendant tout l'intervalle considéré, intéressant chez les sujets peu compliants. Il existe cependant une variabilité individuelle importante de la réponse antihypertensive traduite par la dispersion des valeurs autour de la moyenne de ce rapport TroughlPeak (TIP). Quoi qu'il en soit, il reste à démontrer que le calcul de ce rapport TIP est utile en pratique, notamment par l'objectivation d'une relation entre sa valeur et la prévention des phénomènes de morbidité et de mortalité cardio-vasculaires. [less ▲]

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See detailAminoglycoside Antibiotics Induce Aggregation But Not Fusion Of Negatively-Charged Liposomes
Vanbambeke, F.; Tulkens, Pm.; Brasseur, Robert ULg et al

in European Journal of Pharmacology-Molecular Pharmacology Section (1995), 289(2), 321-33

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical ... [more ▼]

The binding of aminoglycoside antibiotics to acidic phospholipids of membranes is an essential step in the development of both their renal and auditory toxicities, which could be associated with critical modifications of the membrane properties. This work examines the capacity of aminoglycosides to induce membrane aggregation and fusion. Three techniques were used in parallel: (i) measurement of the dequenching rate of a lipid-soluble fluorescent probe (octadecylrhodamine B) incorporated at self-quenched concentration in membranes; (ii) measurement of the increase in the energy transfer between two fluorescent derivatives of phospholipids; and (iii) electron microscopy of negatively-stained replicas. The results were compared with those obtained with spermine (an aggregating polycation) and melittin (a fusogenic peptide). The three approaches indicate that aminoglycosides induce liposomes aggregation, but not fusion. Aggregation is related to the capacity of each drug studied to bind phosphatidylinositol, as evaluated by its energy of interaction with this acidic phospholipid, and to its toxic potential. Membrane aggregation occurring in vivo could therefore contribute to, or be a determinant of this toxicity, which could rationally be screened for new derivatives by the methods applied here. [less ▲]

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See detailEffects of PEEP on systemic vascular compliance in intact pigs
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailVaricella-zoster virus induces apoptosis in cell culture
Sadzot-Delvaux, Catherine ULg; Thonard, P.; Schoonbroodt, Sonia et al

in Journal of General Virology (The) (1995), 76(Pt 11), 2875-2879

Apoptosis is an active mechanism of cell death which can be initiated in response to various stimuli including virus infections. In this work, we demonstrate that lytic infection by varicella-zoster virus ... [more ▼]

Apoptosis is an active mechanism of cell death which can be initiated in response to various stimuli including virus infections. In this work, we demonstrate that lytic infection by varicella-zoster virus (VZV), a human herpesvirus, is characterized by nuclear fragmentation of DNA into oligonucleosomal fragments and by chromatin condensation. In vitro, VZV-induced cell death is actually mediated by apoptosis. The mechanisms developed by cells to protect themselves against apoptosis could be one of the parameters allowing the establishment of virus latency. In the case of VZV, which can remain latent in sensory ganglia, we have not yet identified a cellular or viral protein which could play this protective role, since the observed apoptosis mechanism seems to be independent from Bcl-2, the most frequently described inhibitor of apoptosis. [less ▲]

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See detailGuianensine, a zwitterionic alkaloid from Strychnos guianensis
Quetin-Leclercq, Joëlle; Llabres, Gabriel ULg; Warin, Roger et al

in Phytochemistry (1995), 40(5), 1557-1560

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new ... [more ▼]

The isolation and structure determination of an alkaloid isolated from the stem bark of Strychnos guianensis is described. Elucidation of its structure is based mainly on 1D and 2D NMR studies. The new alkaloid has a zwitterionic asymmetrical bis-indole structure and is named guianensine. [less ▲]

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See detailMolecular biology in support of an old paradigm about the induction of flowering
Périlleux, Claire ULg

in Flowering Newsletter (1995), 20

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See detailAn early origin of plastids within the cyanobacterial divergence is suggested by evolutionary trees based on complete 16S rRNA sequences
Nelissen, Bart; Van De Peer, Yves; Wilmotte, Annick ULg et al

in Molecular Biology and Evolution (1995), 12

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on ... [more ▼]

It is generally accepted that the plastids arose from a cyanobacterial ancestor, but the exact phylogenetic relationships between cyanobacteria and plastids are still controversial. Most studies based on partial 16S rRNA sequences suggested a relatively late origin of plastids within the cyanobacterial divergence. In order to clarify the exact relationship and divergence order of cyanobacteria and plastids, we studied their phylogeny on the basis of nearly complete 16S rRNA gene sequences. The data set comprised 15 strains of cyanobacteria from different morphological groups, 1 prochlorophyte, and plastids belonging to 8 species of plants and 12 species of diverse algae. This set included three cyanobacterial sequences determined in this study. This is the most comprehensive set of complete cyanobacterial and plastidial 16S rRNA sequences used so far. Phylogenetic trees were constructed using neighbor joining and maximum parsimony, and the reliability of the tree topologies was tested by different methods. Our results suggest an early origin of plastids within the cyanobacterial divergence, preceded only by the divergence of two cyanobacterial genera, Gloeobacter and Pseudanabaena. [less ▲]

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See detailSecond-generation octarellins: two new de novo (beta/alpha)8 polypeptides designed for investigating the influence of beta-residue packing on the alpha/beta-barrel structure stability
Houbrechts, Annick ULg; Moreau, Benoît; Abagyan, Ruben et al

in Protein Engineering (1995), 8(3), 249-59

The sequence of octarellin I, the first de novo (beta/alpha)8 polypeptide, was revised according to several criteria, among others the symmetry of the sequence, beta-residue volume and hydrophobicity, and ... [more ▼]

The sequence of octarellin I, the first de novo (beta/alpha)8 polypeptide, was revised according to several criteria, among others the symmetry of the sequence, beta-residue volume and hydrophobicity, and charge distribution. These considerations and the overall conclusions drawn from the first design led to two new sequences, corresponding to octarellins II and III. Octarellin II retains perfect 8-fold symmetry. Octarellin III has the same sequence as octarellin II, except for the beta-strands which exhibit a 4-fold symmetry. The two proteins were produced in Escherichia coli. Infrared and CD spectral analyses of octarellins II and III reveal a high secondary structure content. Non-denaturing gel electrophoresis, molecular sieve chromatography and analytical ultracentrifugation suggest that both of these second-generation artificial polypeptides exist as a mixture of a monomer and a dimer form. Octarellins II and III are at least 10 times more soluble than octarellin I. Urea-induced unfolding followed by fluorescence emission suggests that the tryptophan residues, designed to be buried in the (beta/alpha)8, are indeed packed in the hydrophobic core of both proteins. However, octarellin III displays a higher stability towards urea denaturation, indicating that introducing 4-fold symmetry into the beta-barrel might be important for stability of the overall folding. [less ▲]

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See detailModulation of the Expression of Interstitial and Type-Iv Collagenases in Coculture of Ht1080 Fibrosarcoma Cells and Fibroblasts
Munaut, Carine ULg; Noël, Agnès ULg; Weidle, U. H. et al

in Invasion & Metastasis (1995), 15(5-6), 169-78

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases ... [more ▼]

Members of the metalloproteinase family (MMPs) are known to play a crucial role in the metastatic cascade. Here, we report some investigations about the synthesis of interstitial and type-IV collagenases (gelatinases A and B) in a model of coculture of human fibroblasts and HT 1080 fibrosarcoma cells. The interstitial collagenase activity, mainly found in the conditioned medium of fibroblasts, and its mRNA level were increased in the in vitro coculture model. In contrast, gelatinase A was produced by both cell types. The HT 1080 cells additionally synthesised gelatinase B. In coculture, an enhancement of gelatinase A and the presence of its activated form were observed. Northern blot analysis demonstrated that this enzymatic enhancement occurred at a pretranslational level. The stimulation of the interstitial collagenase activity was partially mediated through soluble factor(s), whereas increased gelatinase A appeared to require direct cell-cell interactions. The extracellular matrix component, type-I collagen, stimulated the enzymatic activities released by the individual cells, but it did not modulate the synthesis of interstitial collagenase in coculture. Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts. [less ▲]

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See detailAvantages environnementaux de l'élevage de porcs sur litière biomaîtrisée
Nicks, Baudouin ULg; Desiron, Alain; Canart, Bernard

in Nouvelles de la Science et des Technologies (1995), 13

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See detailMémoire et imagerie mentale
Van der Linden, Martial ULg; Coyette, Françoise; Meulemans, Thierry ULg

in Questions de Logopédie (1995), 31

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See detailAntihyperglycaemic agents. Drug interactions of clinical importance.
Scheen, André ULg; Lefebvre, Pierre ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (1995), 12(1), 32-45

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias ... [more ▼]

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) affects middle-aged or elderly people who frequently have several other concomitant diseases, especially obesity, hypertension, dyslipidaemias, coronary insufficiency, heart failure and arthropathies. Thus, polymedication is the rule in this population, and the risk of drug interactions is important, particularly in elderly patients. The present review is restricted to the interactions of other drugs with antihyperglycaemic compounds, and will not consider the mirror image, i.e. the interactions of antihyperglycaemic agents with other drugs. Oral antihyperglycaemic agents include sulphonylureas, biguanides--essentially metformin since the withdrawn of phenformin and buformin--and alpha-glucosidase inhibitors, acarbose being the only representative on the market. These drugs can be used alone or in combination to obtain better metabolic control, sometimes with insulin. Drug interactions with antihyperglycaemic agents can be divided into pharmacokinetic and pharmacodynamic interactions. Most pharmacokinetic studies concern sulphonylureas, whose action may be enhanced by numerous other drugs, thus increasing the risk of hypoglycaemia. Such an effect may result essentially from protein binding displacement, inhibition of hepatic metabolism and reduction of renal clearance. Reduction of the hypoglycaemic activity of sulphonylureas due to pharmacokinetic interactions with other drugs appears to be much less frequent. Drug interactions leading to an increase in plasma metformin concentrations, mainly by reducing the renal excretion or the hepatic metabolism of the biguanide, should be avoided to limit the risk of hyperlactaemia. Owing to its mode of action, pharmacokinetic interferences with acarbose are limited to the gastrointestinal tract, but have not been extensively studied yet. Pharmacodynamic interactions are quite numerous and may result in a potentiation of the hypoglycaemic action or, conversely, in a deterioration of blood glucose control. Such interactions may be observed whatever the type of antidiabetic treatment. They result from the intrinsic properties of the coprescribed drug on insulin secretion and action, or on a key step of carbohydrate metabolism. Finally, a combination of 2 to 3 antihyperglycaemic agents is common for treating patients with NIDDM to benefit from the synergistic effect of compounds acting on different sites of carbohydrate metabolism. Possible pharmacokinetic interactions between alpha-glucosidase inhibitors and classical antidiabetic oral agents should be better studied in the diabetic population. [less ▲]

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See detailThe Dissociative Electroionization of Carbon Dioxide by low-energy Electron Impact. The C+, O+ and CO+ Dissociation channels.
Locht, Robert ULg; Davister, M.

in International Journal of Mass Spectrometry and Ion Processes (1995), 144

This work reports the dissociative ionization of CO2 between 19-40 eV. The three dissociation channels producing C+, O+ and CO+ are examined in detail. Translational energy distributions as a function of ... [more ▼]

This work reports the dissociative ionization of CO2 between 19-40 eV. The three dissociation channels producing C+, O+ and CO+ are examined in detail. Translational energy distributions as a function of the impinging electron energy and the ionization efficiency for fixed kinetic energy carried away by the fragments are measured. The kinetic energy versus appearance energy diagram is obtained for the three fragment ions. When available, the present results are compared with previous measurements. The lowest appearance energy of O+ and CO+ corresponds to the predissociation of the CO2+ (C2Sigma +/g) state. At higher energies all the fragment ions are exclusively produced by the dissociative ionization of CO2 in the multiple electron transition (MET) states. Predissociation is most probably the dominant mechanism. Each MET state branches off to produce not only the three fragments but also the same fragment in two different states. This is observed for each dissociation channel, i.e. O+, CO+ and/or C+. In the latter channel no evidence is found for the dissociative ionization reaction CO2+->C++2O. [less ▲]

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See detailVariations temporelles de la phénologie et de la composition biochimique de la phanérogame marine Posidonia oceanica en baie de Calvi
Gobert, Sylvie ULg; Belkhiria, Samy; Dauby, Patrick ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1995), 64

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See detailDNA polymorphism detection in Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae): potential use in stored product pest management
Braet, Yves; Haubruge, Eric ULg

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1995), 6

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See detailPostgastroplasty recovery of ideal body weight normalizes glucose and insulin metabolism in obese women.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1995), 80(2), 364-9

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months ... [more ▼]

To study the metabolic effects of normalizing body weight, a frequently sampled iv glucose tolerance test (0.3 g/kg) was performed before [body mass index (BMI), 37.7 +/- 0.5 kg/m2] and 14 +/- 2 months after successful gastroplasty (BMI, 23.7 +/- 0.6 kg/m2) in eight obese women and, for comparison, in eight age- and weight-matched nonobese control women (BMI, 23.6 +/- 0.7 kg/m2). All subjects had normal oral glucose tolerance. The insulin secretion rate (ISR) was derived by deconvolution of plasma C-peptide levels and the insulin MCR (MCRI) by dividing the 0-180 min area under the curve (AUC) of ISR by that of plasma insulin levels (IRI). The insulin sensitivity index (SI) and the glucose effectiveness index (SG) were calculated using Bergman's minimal model. Before gastroplasty, obese subjects showed higher AUC-IRI (P < 0.001) and AUC-ISR (P < 0.02), lower MCRI (P < 0.005) and SI (P < 0.002), but similar SG values, compared to nonobese controls. After gastroplasty, the AUC-IRI dramatically decreased, due to both a reduction of AUC-ISR (from 58,252 +/- 8,437 to 36,675 +/- 4,274 pmol; P < 0.05) and an increase in MCRI (from 658 +/- 117 to 1,299 +/- 127 mL/min.m-2; P < 0.02). SI significantly rose from 4.74 +/- 0.74 to 9.15 +/- 0.96 10(-5) min-1/pmol.L (P < 0.01), whereas SG remained unchanged. All of these parameters became similar to those in nonobese controls (respectively, 32,522 +/- 3,458, 1,180 +/- 101, and 8.48 +/- 1.25; all P = NS). In conclusion, after gastroplasty-induced normalization of body weight, postobese women recover normal insulin secretion, clearance, and action on glucose metabolism. [less ▲]

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See detailDe la necessite des services d'urgence de la main.
CARLIER, Alain ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1995), 150(7-9), 268-80280-2

Microsurgical techniques have been able to realize anastomoses of small vessels and nerves, with a high rate of success when performed by teams involved in that field. This has changed the concept of ... [more ▼]

Microsurgical techniques have been able to realize anastomoses of small vessels and nerves, with a high rate of success when performed by teams involved in that field. This has changed the concept of surgery of the hand. Reconstruction aims now at a functional result. Organisation of emergencies in hand surgery requires facilitations: hand surgeons, equipment and a team on a 24-hour basis, able to operate any kind of hand trauma. Since 1979, Liege is affiliated to the European Federation. Advantages of the immediate repair are significant repair are significant: reduction of the permanent disability rate, and in many instances, return to work at the same position. In conclusion, early treatment of the injuries of the hand is very effective, but need to be performed by specialists in the field of hand surgery. [less ▲]

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