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See detailCharacterization of hyperporous polyurethane-based gels by non-intrusive mercury porosimetry
Pirard, René ULiege; Rigacci, Arnaud; Marechal, Jacqueline ULiege et al

in Polymer (2003), 44(17), 4881-4887

Evaporative drying of polyurethane-based gels produces xerogels. Supercritical drying after replacement of interstitial liquid by supercritical CO2 produces aerogels. SEM micrographs show that both ... [more ▼]

Evaporative drying of polyurethane-based gels produces xerogels. Supercritical drying after replacement of interstitial liquid by supercritical CO2 produces aerogels. SEM micrographs show that both materials are made up of small size particles gathered up in filament-shaped, strongly cross-linked aggregates. Density measurements show that they both have a large pore volume. When submitted to mercury porosimetry, the behavior of these materials is similar to that of inorganic aerogels, as previously observed. Mercury does not penetrate the pore network, but the whole material is densified. The usual Washburn equation cannot be used to analyze the mercury porosimetry. A well-suited equation based on a buckling model of filament-shaped aggregates has been developed in order to determine the pore volume distribution of mineral dried gels. This equation is also valid for analyzing the texture of organic hyperporous materials like polyurethane dried nanoporous gel. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailHemiurothorax following diaphragmatic hernia and kidney prolapse in a cat.
Stork, Christoph; Hamaide, Annick ULiege; Schwedes, Claudia et al

in Journal of Feline Medicine and Surgery (2003), 5(2), 91-96

A 3-year-old cat was presented with increasing dyspnoea over the past four days. Unilateral pleural effusion was diagnosed and a modified transudate was drained several times. Surgical exploration ... [more ▼]

A 3-year-old cat was presented with increasing dyspnoea over the past four days. Unilateral pleural effusion was diagnosed and a modified transudate was drained several times. Surgical exploration revealed intra-thoracic prolapse of the left kidney and partial herniation of the spleen through a dorsal, circumferential diaphragmatic tear. Biochemical analysis of the pleural fluid confirmed urothorax. Due to excessive fibrin deposit on the well-vascularised kidney it was impossible to re-establish left urinary pathways. Left-sided nephrectomy and diaphragmatic herniorrhaphy were performed. Postoperative recovery was uneventful and complete. This is the first report of an urothorax in veterinary medical literature. (C) 2002 ESFM and AAFP. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailValidation and comparison of the use of diuresis cystometry and retrograde filling cystometry at various infusion rates in female Beagle dogs
Hamaide, Annick ULiege; Verstegen, John; Snaps, Frédéric ULiege et al

in American Journal of Veterinary Research (2003), 64(5), 574-579

OBJECTIVES: To compare retrograde filling cystometry at infusion rates of 5, 10, and 20 mL/min with diuresis cystometry for determination of an appropriate infusion rate and to confirm the reproducibility ... [more ▼]

OBJECTIVES: To compare retrograde filling cystometry at infusion rates of 5, 10, and 20 mL/min with diuresis cystometry for determination of an appropriate infusion rate and to confirm the reproducibility of measurements obtained by urethral pressure profilometry (UPP) and cystometry in female Beagles. ANIMALS: Adult female Beagles. PROCEDURE: Successive UPP and cystometry were performed by use of a water perfusion catheter on dogs anesthetized with propofol. Dogs randomly underwent each of the following at 1-week intervals: retrograde filling cystometry at 5, 10, and 20 mL/min, and diuresis cystometry. The maximum urethral pressure and closure pressure, functional and anatomic profile lengths, threshold pressure, threshold volume, and compliance were measured. RESULTS: For each UPP variable, significant differences were found among dogs, but no significant differences were found in intra- or interstudy measurements for individual dogs. For retrograde filling cystometry, threshold pressure was not significantly different between a 5 and 10 mL/min infusion rate. Threshold pressure was significantly higher during retrograde filling cystometry at 20 mL/min, compared with 5 and 10 mL/min, and was associated with bladder wall damages. Threshold pressure was significantly lower during diuresis cystometry, compared with retrograde filling cystometries. Threshold volume and compliance were not significantly different among retrograde filling cystometries but were significantly higher during diuresis cystometry. CONCLUSIONS AND CLINICAL RELEVANCE: Retrograde filling cystometry at 20 mL/min leads to unacceptable sudden increase in threshold bladder pressure. Retrograde filling cystometry at 10 mL/min can be recommended in a clinical setting, shortening the anesthesia time. However, diuresis cystometry approximates physiologic bladder filling most accurately [less ▲]

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See detailPrevalence and identity of cdt-related sequences in necrotoxigenic Escherichia coli
Mainil, Jacques ULiege; Jacquemin, E.; Oswald, E.

in Veterinary Microbiology (2003), 94

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See detailShellfish, a dangerous food?
China, Bernard; de Schaetzen, Marie-Athénaïs ULiege; Daube, Georges ULiege

in Annales de Médecine Vétérinaire (2003), 147(6, DEC-JAN), 413-422

Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter ... [more ▼]

Sea products are consumed worldwide. Seafood, especially shellfish, is consumed crude or not well cooked therefore they are risky for the development of foodborne diseases. Moreover, these animals filter water and concentrate the microorganisms and the toxins. Risks are multiple : bacteria (Clostridium, Vibrio), viruses (norovirus, hepatitis A) and the biotoxins (paralytic, neurotoxic, diarrhoeic and amnesic) produced by phytoplankton. The European regulation 91/492/EC indicates the microbiological and toxicological criteria for the sale of the shellfish. Nevertheless, in the absence of good diagnosis methods, the viruses were omitted in this regulation. But it is a major cause of toxi-infection due to shellfish consumption. The large number of outbreaks worldwide due to the ingestion of seafood indicates that these ones must be carefully controlled. Therefore, we need powerful diagnosis tools. The aim of this review is to describe the major biological risks (bacteria, viruses, biotoxins) for the human health linked to the consumption of sea food. [less ▲]

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See detailHepatitis C: screening, treatment and prevention practical guidelines
Michielsen, P.; Brenard, R.; Bourgeois, N. et al

in Acta Gastro-Enterologica Belgica (2003), 66(1), 15-19

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ [less ▲]

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See detailEstado, mercado y diversidad cultural
Martiniello, Marco ULiege

in Revista de Occidente (Madrid, Spain : 1923) (2003), 268

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See detailDistribution of surface carbon dioxide and air-sea exchange in the English Channel and adjacent areas
Borges, Alberto ULiege; Frankignoulle, Michel

in Journal of Geophysical Research (2003), 108(C5),

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal ... [more ▼]

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal variability of pCO2 is controlled by a complex combination of primary production (from May to June), degradation of organic matter, temperature change, and freshwater inputs. Preliminary air-sea CO2 exchange computations suggest that the Channel is not a major sink of atmospheric CO2 and is probably neutral from the point of view of atmospheric coupling. This is mainly related to a relatively low export and/or burial of organic carbon and intense benthic calcification. [less ▲]

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See detailAn Integrated Software for Scantling Optimization and Least Production Cost
Rigo, Philippe ULiege

in Ship Technology Research = Schiffstechnik (2003)

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See detailSoluble transferrin receptor for the evaluation of erythropoiesis and iron status.
Beguin, Yves ULiege

in Clinica Chimica Acta (2003), 329(1-2), 9-22

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR ... [more ▼]

Iron transport in the plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor, the transferrin receptor (TfR). A soluble form of the TfR (sTfR) has been identified in animal and human serum. Soluble TfR is a truncated monomer of tissue receptor, lacking its first 100 amino acids, which circulates in the form of a complex of transferrin and its receptor. The erythroblasts rather than reticulocytes are the main source of serum sTfR. Serum sTfR levels average 5.0+/-1.0 mg/l in normal subjects but the various commercial assays give disparate values because of the lack of an international standard. The most important determinant of sTfR levels appears to be marrow erythropoietic activity which can cause variations up to 8 times below and up to 20 times above average normal values. Soluble TfR levels are decreased in situations characterized by diminished erythropoietic activity, and are increased when erythropoiesis is stimulated by hemolysis or ineffective erythropoiesis. Measurements of sTfR are very helpful to investigate the pathophysiology of anemia, quantitatively evaluating the absolute rate of erythropoiesis and the adequacy of marrow proliferative capacity for any given degree of anemia, and to monitor the erythropoietic response to various forms of therapy, in particular allowing to predict response early when changes in hemoglobin are not yet apparent. Iron status also influences sTfR levels, which are considerably elevated in iron deficiency anemia but remain normal in the anemia of inflammation, and thus may be of considerable help in the differential diagnosis of microcytic anemia. This is particularly useful to identify concomitant iron deficiency in a patient with inflammation because ferritin values are then generally normal. Elevated sTfR levels are also the characteristic feature of functional iron deficiency, a situation defined by tissue iron deficiency despite adequate iron stores. The sTfR/ferritin ratio can thus describe iron availability over a wide range of iron stores. With the exception of chronic lymphocytic leukemia (CLL) and high-grade non-Hodgkin's lymphoma and possibly hepatocellular carcinoma, sTfR levels are not increased in patients with malignancies. We conclude that soluble TfR represents a valuable quantitative assay of marrow erythropoietic activity as well as a marker of tissue iron deficiency. [less ▲]

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See detailMagneto-transport study of nb-doped Bi/Pb2223 superconductor
Pekala, Marek; Mucha, Jan ULiege; Cloots, Rudi ULiege et al

in Physica C: Superconductivity (2003), 387(1-2), 191-197

The magneto-transport properties of Bi1.5Pb0.4Nb0.1Sr2Ca2Cu3O10-x polycrystalline, superconducting ceramic are reported. The material was found to be chemically homogeneous and partially textured. The ... [more ▼]

The magneto-transport properties of Bi1.5Pb0.4Nb0.1Sr2Ca2Cu3O10-x polycrystalline, superconducting ceramic are reported. The material was found to be chemically homogeneous and partially textured. The mixed state properties were investigated by measuring the electrical resistivity, longitudinal and transverse (Nernst effect) thermoelectric power, and thermal conductivity. The magnetization and AC susceptibility measurements were also performed. The variation of these characteristics for magnetic fields up to 5 T are discussed and compared to those of the zero field case. The transport entropy and thermal Hall angle are extracted and quantitatively compared to previously reported data of closely related systems. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDaily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial
Van Vlierberghe, H.; Leroux-Roels, G.; Adler, M. et al

in Journal of Viral Hepatitis (2003), 10(6), 460-466

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the ... [more ▼]

The standard treatment for patients with chronic hepatitis C is a 6-12-month combination therapy with interferon alpha and ribavirin. Induction treatment could result in a faster early decline of the hepatitis C virus (HCV) load and a better response rate. Naive chronically infected HCV patients (n = 454) were randomized into two arms to receive either induction treatment with interferon alpha 2b 5 million units (MU) subcutaneously (s.c.) daily during a period of 8 weeks (arm A); or treatment with interferon alpha 2b 5 MU s.c. three times a week (TIW) for a period of 8 weeks (arm B). After week 8, interferon treatment in both arms was 3 MU s.c. TIW for a total period of 12 months. In both arms, ribavirin (1000-1200 mg orally per day) was added at week 4. Induction treatment resulted in a higher virological response at week 8 of treatment (66%vs 47%; P < 0.01). However, response at the end of treatment and at 6 months follow-up was not different (53%vs 50%, 41%vs 33%). The occurrence of adverse events and the drop-out rate were similar in both arms. Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ. [less ▲]

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See detailQuantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology
Geenen, Vincent ULiege; Poulin, J. F.; Dion, M. L. et al

in Journal of Endocrinology (2003), 176(3), 305-311

Although the thymus constitutes a target organ for most protein and steroid hormones, it has been quite difficult to determine the precise control exerted in vivo by the endocrine system upon thymic ... [more ▼]

Although the thymus constitutes a target organ for most protein and steroid hormones, it has been quite difficult to determine the precise control exerted in vivo by the endocrine system upon thymic function. The biological role of the thymus is to ensure the generation of a diversified population of peripheral T cells able to respond to non-self-antigens but nevertheless tolerant to self-antigens. For a long time, thymic function could not be monitored, as a consequence of the absence of adequate technology to differentiate recent thymic emigrants from naive T cells. The generation of T cell receptor (TCR) diversity occurs in the thymus through recombination of gene segments encoding the variable parts of the TCR alpha and beta chains. During these processes, by-products of the rearrangements are generated in the form of TCR excision circles (TRECs). As these molecules are lost upon further cell division, their quantification is actually considered as a very valuable tool to estimate thymic function. The most appropriate TREC is deltaRec-Psi(J)alpha TREC or signal joint TREC resulting from deltaRec-Psi(J)alpha rearrangement (TCRD deletion) that occurs late during thymopoiesis, before V(alpha)-J(alpha) rearrangement. Here we describe how TREC quantification is a powerful and reliable method to evaluate the impact of hormones and endocrine disorders upon thymic function [less ▲]

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See detailRetreatment of hepatitis C non-responsive to interferon. A placebo controlled randomized trial of ribavirin monotherapy versus combination therapy with Ribavirin and Interferon in 121 patients in the Benelux [ISRCTN53821378]
Veldt, Bart J; Brouwer, Johannes T; Adler, Michael et al

in BMC Gastroenterology (2003), 3(1), 24

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large ... [more ▼]

BACKGROUND: Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised controlled trial where combination therapy was compared to placebo therapy and to ribavirin monotherapy, which has not been published until now. METHODS: One hundred and twenty one patients with chronic hepatitis C and elevated transaminases who did not respond to previous treatment with standard interferon monotherapy, were included from 16 centers in Belgium, the Netherlands and Luxembourg between 1992 and 1996. Patient poor-response characteristics were: genotype 1 (69%), HCV RNA above 2 x 10(6) copies/ml (55%) and cirrhosis (38%). Patients were randomized to 6 months combination therapy with interferon alpha-2b (3 MU tiw) and ribavirin (1000-1200 mg/day), 6 months ribavirin monotherapy (1000-1200 mg/day) or 6 months ribavirin placebo. The study was double blinded for the ribavirin/placebo component. One patient did not fit the entry criteria, and 3 did not start. All 117 patients who received at least one dose of treatment were included in the intention to treat analysis. RESULTS: At the end of treatment, HCV RNA was undetectable in 35% of patients on combination therapy and in none of the patients treated with ribavirin monotherapy or placebo. The sustained virological response rate at 6 months after therapy was 15% for patients treated with interferon and ribavirin.During the 6 months treatment period 13% of patients on interferon ribavirin combination therapy, 13% of patients on ribavirin monotherapy and 11% of patients on placebo withdrew due to side effects or noncompliance. At 24 weeks of treatment the mean Hb level was 85% of the baseline value, which means a mean decrease from 9.1 mmol/l to 7.8 mmol/l. The Hb levels at the end of treatment were not significantly different from patients treated with ribavirin monotherapy (p = 0.76). End of treatment WBC was significantly lower in patients treated with combination therapy, compared to ribavirin (p < 0.01) as well as for patients treated with ribavirin monotherapy compared to placebo (p < 0.01). DISCUSSION: This belated report on the only placebo controlled study of interferon ribavirin combination therapy in non responders to standard doses of interferon monotherapy documents the effectiveness, be it limited, of this approach as well as the dynamics of the effects on blood counts. [less ▲]

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See detailFormation Of Plant Cuticle: Evidence For The Occurrence Of The Peroxygenase Pathway
Lequeu, J.; Fauconnier, Marie-Laure ULiege; Chammai, A. et al

in Plant Journal (The) (2003), 36(2),

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See detailPreventing, delaying, or masking type 2 diabetes with metformin in the diabetes prevention program?
Scheen, André ULiege

in Diabetes Care (2003), 26(9), 27012701-3

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See detailTwo distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications
Terrak, Mohammed ULiege; Wu, G.; Stafford, W. F. et al

in EMBO Journal (2003), 22(3), 362-71

IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized ... [more ▼]

IQ motifs are widespread in nature. Mlc1p is a calmodulin-like myosin light chain that binds to IQ motifs of a class V myosin, Myo2p, and an IQGAP-related protein, Iqg1p, playing a role in polarized growth and cytokinesis in Saccharomyces cerevisiae. The crystal structures of Mlc1p bound to IQ2 and IQ4 of Myo2p differ dramatically. When bound to IQ2, Mlc1p adopts a compact conformation in which both the N- and C-lobes interact with the IQ motif. However, in the complex with IQ4, the N-lobe no longer interacts with the IQ motif, resulting in an extended conformation of Mlc1p. The two light chain structures relate to two distinct subfamilies of IQ motifs, one of which does not interact with the N-lobes of calmodulin-like light chains. The correlation between light chain structure and IQ sequence is demonstrated further by sedimentation velocity analysis of complexes of Mlc1p with IQ motifs from Myo2p and Iqg1p. The resulting 'free' N-lobes of myosin light chains in the extended conformation could mediate the formation of ternary complexes during protein localization and/or partner recruitment. [less ▲]

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See detailPrevention of cardiovascular disease: plea for a rationale use of diet and lipid-lowering drugs.
Scheen, André ULiege

in Acta Clinica Belgica (2003), 58(3), 149-51

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See detailSystemic osmotic manipulations modulate ethanol-induced taurine release : a brain microdialysis study
Quertemont, Etienne ULiege; Devitgh, Audrey; De Witte, Philippe

in Alcohol (2003), 29(1), 11-19

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol ... [more ▼]

In recent microdialysis studies, increased extracellular concentrations of taurine after high ethanol dose administration were identified in various rat brain regions. The mechanisms by which ethanol caused these increases in extracellular taurine concentration remained unclear but could be related to ethanol-induced cell swelling. The aim of the current study was to investigate whether changes in the body osmotic state modulate the effects of ethanol on brain extracellular taurine concentrations. In several groups of rats, brain hypoosmotic or hyperosmotic states were superimposed on acute ethanol (2.0-g/kg) injections, and extracellular taurine concentrations within the nucleus accumbens were assessed by using an intracerebral microdialysis procedure. A hypoosmotic state was obtained by systemic administration of water while hyperosmotic states were induced by intraperitoneal injections of hypertonic saline solutions (1.8% or 3.6% saline). In isoosmotic conditions, ethanol induced an immediate and significant increase in taurine microdialysate content, confirming results of previous studies. However, the effects of ethanol on taurine concentrations were modulated by osmotic manipulations. Hypoosmotic conditions significantly potentiated ethanol-induced taurine release. In contrast, ethanol-induced increases in extracellular taurine levels were attenuated by 1.8% saline injection and totally prevented by 3.6% saline administration. These results strongly argue in favor of a primary role, of osmoregulation in ethanol-induced taurine release. Ethanol-induced cell swelling probably activates volume-sensitive channels, and taurine passively diffuses outside the cells along its concentration gradient. (C) 2003 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailCurrent management strategies for coexisting diabetes mellitus and obesity.
Scheen, André ULiege

in Drugs (2003), 63(12), 1165-84

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular ... [more ▼]

Besides genetic predisposition, obesity is the most important risk factor for the development of diabetes mellitus. Weight reduction has been shown to markedly improve blood glucose control and vascular risk factors associated with insulin resistance in obese individuals with type 2 diabetes. Therapeutic strategies for the obese diabetic patient include: (i) promoting weight loss, through lifestyle modifications (low-calorie diet and exercise) and antiobesity drugs (orlistat, sibutramine, etc.); (ii) improving blood glucose control, through agents decreasing insulin resistance (metformin or thiazolidinediones, e.g. pioglitazone and rosiglitazone) or insulin needs (alpha-glucosidase inhibitors, e.g. acarbose) in preference to agents stimulating defective insulin secretion (sulphonylureas, meglitinide analogues); and (iii) treating common associated risk factors, such as arterial hypertension and dyslipidaemias, to improve cardiovascular prognosis. Whenever insulin is required by the obese diabetic patient after failure to respond to oral drugs, it should be preferably prescribed in combination with an oral agent, more particularly metformin or acarbose, or possibly a thiazolidinedione. When morbid obesity is present, both restoring a good glycaemic control and correcting associated risk factors can only be obtained through a marked and sustained weight loss. This objective justifies more aggressive weight reduction programmes, including very-low-calorie diets and bariatric surgery, but only within a multidisciplinary approach and long-term strategy. [less ▲]

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See detailDas rheinische "tschö"
Möller, Robert ULiege

in Rheinische Vierteljahrsblätter (2003), 65

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See detailNonalcoholic steatohepatitis and insulin resistance: interface between gastroenterologists and endocrinologists.
Scheen, André ULiege; Luyckx, Françoise ULiege

in Acta Clinica Belgica (2003), 58(2), 81-91

Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity ... [more ▼]

Nonalcoholic steatohepatitis (NASH), along with other forms of nonalcoholic fatty liver disease, is an increasingly common clinico-pathological syndrome. It is frequently associated with obesity, especially visceral fat, and type 2 diabetes, and is intimately related to markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridemia and impaired glucose tolerance. The pathophysiology of NASH involves two steps: 1) insulin resistance, which causes steatosis; 2) and oxidative stress, which produces lipid peroxidation and activates inflammatory cytokines. The identification of subjects who may progress from fatty liver to NASH, and from NASH to fibrosis/cirrhosis is an important clinical challenge as well as the finding of appropriate therapy that could prevent such deleterious process. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by an important regression of liver steatosis in most patients, although mild inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome and perhaps being part of it. [less ▲]

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See detailThe State, the Market and Cultural Diversity
Martiniello, Marco ULiege

in Immigrants & Minorities (2003), 22(2-3), 127-140

This essay compares the logic of states & the logic of markets in the management of cultural diversity. On the one hand, the economic logic of markets leads to an encouragement of a 'soft' cultural ... [more ▼]

This essay compares the logic of states & the logic of markets in the management of cultural diversity. On the one hand, the economic logic of markets leads to an encouragement of a 'soft' cultural diversity associated with the marketing of exoticism in music, the arts, & cuisine, for example. On the other hand, the liberal states are trapped between their willingness to recognize some form of diversity & their fear of seeing social cohesion harmed by this recognition. In other words, the essay applies Hollified's hypothesis about the liberal paradox in immigration policy to the sphere of cultural diversity in post-immigration situations. Adapted from the source document. [less ▲]

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See detailNew ruthenium catalysts bearing N-heterocyclic carbene ligands for ATRP
Tudose, Adriana; Delfosse, Sébastien; Richel, Aurore ULiege et al

in e-polymers (2003)

New ruthenium catalysts bearing N-heterocyclic carbene ligands in Kharasch chemistry

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See detailFirst order elastic modeling of the Aden ridge propagation and the Anatolian extrusion process
Hubert, Aurelia ULiege; King, G. C. P.; Manighetti, I. et al

in Geophysical Journal International (2003), 153

The evolution of the Gulf of Aden and the Anatolian Fault systems are modelled using the principles of elastic fracture mechanics usually applied to smaller scale cracks or faults. The lithosphere is ... [more ▼]

The evolution of the Gulf of Aden and the Anatolian Fault systems are modelled using the principles of elastic fracture mechanics usually applied to smaller scale cracks or faults. The lithosphere is treated as a plate, and simple boundary conditions are applied that correspond to the known plate boundary geometry and slip vectors. The models provide a simple explanation for many observed geological features. For the Gulf of Aden the model predicts why the ridge propagated from east to west from the Owen Fracture Zone towards the Afar and the overall form of its path. The smaller en echelon offsets can be explained by upward propagation from the initially created mantle dyke while the larger ones may be attributed to the propagating rupture interacting with pre-existing structures. For Anatolia the modelling suggests that the East Anatolian Fault was created before the North Anatolian Fault could form. Once both faults were formed however, activity could switch between them. The time scales over which this should take place are not known, but evidence for switching can be found in the historical seismicity. For Aden and Anatolia pre-existing structures or inhomogeneous stress fields left from earlier orogenic events have modified the processes of propagation and without an understanding of the existence of such features the propagation processes cannot be fully understood. Furthermore a propagating fault can extend into an active region where it would not have initiated. The North Anatolian Fault encountered slow but active extension when it entered the Aegean about 5 Ma and the stress field associated with the extending fault has progressively modified Aegean extension. In the central Aegean activity has been reduced while to the north-west on features such as the Gulfs of Evvia and Corinth activity has been increased. The field observation that major structures propagate and the success of simple elastic mod- els suggest that the continental crust behaves in an elastic-brittle or elastic-plastic fashion even though laboratory tests may be interpreted to suggest viscous behaviour. There are major prob- lems in scaling from the behaviour of small homogeneous samples to the large heterogeneous mantle and large-scale observations should be treated more seriously than extrapolations of the behaviour of laboratory experiments over many orders of magnitude in space and time. The retention of long-term elasticity and localised failure suggests a similar gross rheology for the oceanic and continental lithospheres. Even though it is incorrect to attribute differences in behaviour to the former being rigid (i.e. elastic) and the latter viscous, oceanic and continental lithosphere behave in different ways. Unlike oceanic crust, continental crust is buoyant and cannot be simply created or destroyed. The process of thickening or thinning works against gravity preventing large displacements on extensional or contractional features in the upper mantle. The equivalents of ridge or subduction systems are suppressed before they can accom- modate large displacements and activity must shift elsewhere. On the other hand, strike-slip boundaries and extrusion processes are favoured. [less ▲]

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See detailIs there a role for alpha-glucosidase inhibitors in the prevention of type 2 diabetes mellitus?
Scheen, André ULiege

in Drugs (2003), 63(10), 933-51

Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to ... [more ▼]

Type 2 diabetes mellitus is a major health problem associated with excess morbidity and mortality. As the prevalence of this metabolic disorder is rapidly increasing and current treatment fails to stabilise the disease in most patients, prevention should be considered as a key objective in the near future. People who develop type 2 diabetes pass through a phase of impaired glucose tolerance (IGT). Defects in the action and/or secretion of insulin are the two major abnormalities leading to development of glucose intolerance. Any intervention in the impaired glucose tolerance phase that reduces resistance to insulin or protects the beta-cells, or both, should prevent or delay progression to diabetes.Acarbose, miglitol and voglibose act by competitively inhibiting the alpha-glucosidases, a group of key intestinal enzymes involved in the digestion of carbohydrates. They decrease both postprandial hyperglycaemia and hyperinsulinaemia, and thereby may improve sensitivity to insulin and release the stress on beta-cells. These compounds do not induce hypoglycaemia and have a good safety profile, although gastrointestinal adverse effects may limit long-term compliance to therapy.The recent placebo-controlled prospective STOP-noninsulin-dependent diabetes mellitus (STOP-NIDDM) trial demonstrated that acarbose 100mg three times daily reduces the risk of developing type 2 diabetes in patients with IGT (relative risk reduction of 25% after a mean follow-up of 3.3 years). The 6-year Early Diabetes Intervention Trial (EDIT), comparing the effect of acarbose 50mg three times daily to that of metformin, showed a trend to a positive effect of acarbose compared with placebo, in a mid-term 3-year analysis, which should be confirmed in the final analysis.To our knowledge, no such prevention intervention trials have been or are currently being performed with miglitol or voglibose. In conclusion, because of its absence of toxicity and its particular mechanism of action on gastrointestinal tract and indirect consequences on both insulin action and beta-cell function, acarbose may be used to prevent type 2 diabetes. If the ongoing EDIT trial confirms the positive results of the recent STOP-NIDDM trial, acarbose could be used, either as an alternative or in addition to changes in lifestyle, to delay development of diabetes in patients with IGT. However, the best dosage of acarbose for this specific indication remains to be specified, especially when all three important parameters, efficacy, tolerance and cost, are taken into consideration. [less ▲]

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See detailHow Daphnia copes with excess carbon in its food
Darchambeau, François ULiege; Faerovig, P. J.; Hessen, D. O.

in Oecologia (2003), 136(3), 336-346

Animals that maintain near homeostatic elemental ratios may get rid of excess ingested elements from their food in different ways. C regulation was studied in juveniles of Daphnia magna feeding on two ... [more ▼]

Animals that maintain near homeostatic elemental ratios may get rid of excess ingested elements from their food in different ways. C regulation was studied in juveniles of Daphnia magna feeding on two Selenastrum capricornutum cultures contrasting in P content (400 and 80 C:P atomic ratios). Both cultures were labelled with C-14 in order to measure Daphnia ingestion and assimilation rates. No significant difference in ingestion rates was observed between P-low and P-rich food, whereas the net assimilation of C-14 was higher in the treatment with P-rich algae. Some Daphnia were also homogeneously labelled over 5 days on radioactive algae to estimate respiration rates and excretion rates of dissolved organic C (DOC). The respiration rate for Daphnia fed with high C:P algae (38.7% of body C day(-1)) was significantly higher than for those feeding on low C:P algae (25.3% of body C day(-1)). The DOC excretion rate was also higher when animals were fed on P-low algae (13.4% of body C day(-1)) than on P-rich algae (5.7% of body C day(-1)) . When corrected for respiratory losses, total assimilation of C did not differ significantly between treatments (around 60% of body C day(-1)). Judging from these experiments, D. magna can maintain its stoichiometric balance when feeding on unbalanced diets (high C:P) primarily by disposing of excess dietary C via respiration and excretion of DOC. [less ▲]

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See detailInsectes et communication
Arnaud, Ludovic; Detrain, Claire; Gaspar, Charles et al

in Journal des Ingénieurs (Le) (2003), 87

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See detailLa participation du plaignant à la procédure en infraction au droit communautaire diligentée par la Commission
Munoz, Rodolphe ULiege

in Revue du Marché Commun et de l'Union Européenne (2003), 472

La procédure en manquement est l’instrument principal de la Commission pour assurer que le droit communautaire est correctement mis en oeuvre au niveau national. La majorité des affaires, traitées dans le ... [more ▼]

La procédure en manquement est l’instrument principal de la Commission pour assurer que le droit communautaire est correctement mis en oeuvre au niveau national. La majorité des affaires, traitées dans le cadre de ce recours, a son origine dans les plaintes provenant de personnes physiques ou morale. Cependant, la Commission conserve un droit de regard important dans la mise en oeuvre de la procédure en manquement. En effet, elle est la seule à décider de l’opportunité d’ouvrir une procédure en manquement et peut à tout moment de la procédure décider d’arrêter les poursuites contre un Etat. Cette liberté s’explique par le fait que la Commission est une institution indépendante et représentant l’intérêt général communautaire. Cependant, il est logique que l’intérêt communautaire puisse ne pas coïncider avec l’intérêt des particuliers. Par conséquent, à plusieurs reprises les particuliers ont tenté de limiter ce pouvoir discrétionnaire de la Commission. Néanmoins, la Cour de justice a toujours refusé de remettre en cause ce pouvoir. Cette communication a pour but de clarifier les pouvoirs de la Commission. De fait, suite à une affaire portée devant le médiateur, la Commission s’est engagée à "codifier" les pratiques existantes afin que les plaignants connaissent l’ensemble des différents stades de la procédure. Ainsi, cette communication donne une vision globale de la gestion des plaintes par la Commission. [less ▲]

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See detailInfluence of a nonlinear reference temperature profile on oscillatory Benard-Marangoni convection.
Dondlinger, M.; Colinet, P.; Dauby, Pierre ULiege

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2003), 68(6 Pt 2), 066310

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile ... [more ▼]

We analyze oscillatory instabilities in a fluid layer of infinite horizontal extent, heated from above or cooled from below, taking into account the nonlinearity of the reference temperature profile during the transient state of heat conduction. The linear stability analysis shows that a nonlinear reference temperature profile can have a strong effect on the system, either stabilizing or destabilizing, depending on the relative importance of buoyancy and surface tension forces. For the nonlinear analysis we use a Galerkin-Eckhaus method leading to a finite set of amplitude equations. In the two-dimensional (2D) case, we show the solution of these amplitude equations are standing waves. [less ▲]

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See detailSynthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process
Hale, K. J.; Frigerio, M.; Manaviazar, S. et al

in Organic Letters (2003), 5(4), 499-502

[GRAPHICS] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in (CH3CN)-H-2 containing 25% (H2O)-H-2 have shown that it binds ... [more ▼]

[GRAPHICS] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in (CH3CN)-H-2 containing 25% (H2O)-H-2 have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1). NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1. [less ▲]

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See detailIrritation cutanee et vitesse de propagation d'ondes ultrasonores.
Uhoda, Emmanuelle ULiege; Pierard, Gérald ULiege

in International Journal of Cosmetic Science (2003), 25(1-2), 31-5

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief ... [more ▼]

Cutaneous irritation is a stereotyped response of the skin to any physical or chemical insult. Its main manifestations encompass inflammatory erythema and an alteration of the cutaneous microrelief showing increased roughness, dehydration and erratic desquamation. Several instrumental methods can indirectly assess the issues of cutaneous irritation on human stratum corneum. The aim of the present study was to measure the speed of propagation of ultrasound shear waves in the skin irritated by anionic surfactants. The study was performed in 25 healthy subjects of both sexes. Occlusive patches of a 10% solution of anionic surfactants were applied to a forearm of each volunteer. The other forearm served as an untreated control site. Patches remained in place for 24 h. Three hours later, another patch was placed again for 21 h. Resonance running time measurements (RRTM) of the ultrasound shear wave were performed using a Reviscometer((R)) RVM 600. Measurements were performed at entry in the study and 2 days after removing the second patch. Desquamative xerosis was obvious at the sites patched with the surfactant solution. RRTM values were significantly (P < 0.0001) lower than those at the control site. Hence, the speed of propagation of ultrasound shear waves was shown to be increased at an irritated site compared to an intact site. In conclusion, this study shows that the propagation speed of ultrasounds is influenced by the skin surface nature, being considerably increased in skin altered by surfactants. [less ▲]

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See detailTreatment of type 2 diabetes.
Scheen, André ULiege

in Acta Clinica Belgica (2003), 58(5), 318-24

Type 2 diabetes is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. As most subjects are overweighted or obese, the initial treatment ... [more ▼]

Type 2 diabetes is a heterogeneous disease resulting from a dynamic interaction between defects in insulin secretion and insulin action. As most subjects are overweighted or obese, the initial treatment is optimization of the meal plan and enhancement of physical activity in order to obtain sustained weight reduction. In case of failure of life-style changes, various oral antihyperglycaemic agents may be used. Some are targeting defective insulin secretion (sulphonylureas, glinides) while others are targeting insulin resistance (metformin, thiazolidinediones). Criteria of drug selection should include both patient's characteristics (body weight, age, degree of hyperglycaemia, comorbidities) and pharmacological properties of the compound (mode of action, safety profile, cost). Monotherapy is usually recommended first, but combined therapy using drugs with additive or synergistic effects may be required to obtain appropriate blood glucose control. As the natural history of the disease is characterized by a progressive exhaustion of beta cells, exogenous insulin may be required in the long term, usually in combination with oral agents. Finally, as patients with type 2 diabetes are insulin-resistant and often have a metabolic syndrome, a multifactorial intervention including aggressive treatment of arterial hypertension and dyslipidaemia is recommended in order to reduce the incidence of cardiovascular complications. [less ▲]

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See detailBiomarquers d’exposition en milieu terrestre : impact d’hydrocarbures halogénés sur l’activité de trois systèmes enzymatiques chez Drosophila pseudoobscura
Dannau, Marie; Amichot, Marcel; Leenaers, Lionel et al

in Environnement Risques & Santé (2003), 2

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See detailCarbohydrates and resistance to Phytophthora infestans in potato plants
Evers, Danièle; Dommes, Jacques ULiege; Hausman, Jean-François

in Acta Physiologiae Plantarum (2003), 25(2), 171-178

Plants generally deal with biotic or abiotic stresses by altering components as for example cell wall constituents and metabolites. Infection by Phytophthora infestans, the causal agent of late blight ... [more ▼]

Plants generally deal with biotic or abiotic stresses by altering components as for example cell wall constituents and metabolites. Infection by Phytophthora infestans, the causal agent of late blight, constitutes a stress condition for the plants and they react to it with changes arising in their metabolism depending on the resistance level of the plants. The present work compares two potato hybrids differing in their level of horizontal resistance to late blight. Carbohydrate content in stems and leaves of infected and uninfected plants was determined by HPLC. Some carbohydrates accumulated in the stems of the resistant hybrid infected by P. infestans, whereas they remained unchanged in the susceptible hybrid. On the other hand, in the leaves, these carbohydrates accumulated only in the infected susceptible hybrid. [less ▲]

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See detailVirus infections in pathogenesis of type 1 diabetes
Brilot, Fabienne; Geenen, Vincent ULiege

in International Diabetes Monitor (2003), 14

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See detailQuantification of angiogenesis on the rat aortic ring assay.
Blacher, Silvia ULiege; Devy, L.; Noël, Agnès ULiege et al

in Image Analysis and Stereology (2003), 22

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total ... [more ▼]

Image analysis is used to quantify angiogenesis on the rat aortic ring model. This technique allows to determine: (1) the aortic ring area and factor shape; (2) the number of microvessels, the total number of branching, the maximal microvessel length and the number of microvessels in function of the distance to the aortic ring; (3) the total number of isolated fibroblast-like cells and the number of fibroblast-like cells in function of the distance to the aortic ring. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by vascular endothelial growth factor (VEGF). [less ▲]

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See detailPreparation of nanosized barium zirconate powder by thermal decomposition of urea in an aqueous solution containing barium and zirconium, and by calcination of the precipitate
Boschini, Frédéric ULiege; Robertz, B.; Rulmont, André ULiege et al

in Journal of the European Ceramic Society (2003), 23(16), 3035-3042

The synthesis of barium zirconate was initiated by urea induced homogeneous precipitation followed by a "low temperature" thermal treatment. The kinetic of the reaction and the optimum urea/cation ratio ... [more ▼]

The synthesis of barium zirconate was initiated by urea induced homogeneous precipitation followed by a "low temperature" thermal treatment. The kinetic of the reaction and the optimum urea/cation ratio have been determined by means of X-ray diffraction and Inductive Coupled Plasma analyses. It has been demonstrated that an amorphous zirconium hydrated oxide starts to precipitate followed by the precipitation of barium carbonate. A calcination at 1200 degreesC during 2 h gives rise to the formation of a pure barium zirconate phase. Microstructural characterisations have been performed in order to evaluate the sintering behaviour. Dilatometric measurements, coupled with scanning electron microscopy analyses clearly indicate that barium carbonate decomposition process leads to the formation of internal porosity which severely limits the density of the material, even if a sintering was performed at 1500 degreesC. A careful control of the heating profile seems to be necessary in order to produce dense materials. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailProsthetic vascular infection complicated or not by aortoenteric fistula: comparison of treatment with and without cryopreserved allograft (homograft).
Lavigne, Jean-Paul ULiege; Postal, Alain ULiege; Kolh, Philippe ULiege et al

in European Journal of Vascular and Endovascular Surgery (2003), 25(5), 416-23

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study ... [more ▼]

OBJECTIVES: in patients with vascular prosthesis infection, to compare surgical outcome and long-term results of cryopreserved allograft implantations to conventional surgery. DESIGN: retrospective study. MATERIAL AND METHODS: two asynchronous series of 44 [series I: 1980-1994; 8 patients with aortoenteric fistula (AEF)] and 22 (series II: 1994-1997; 4 patients with AEF) patients were treated for prosthesis infection. All patients had prosthesis excision. In series I, there were 4 in situ reparations, 26 extra-anatomic bypass, 13 excision only, and one death at laparotomy. In series II, in situ cryopreserved allografts were implanted in all patients. RESULTS: operative mortality was 16% in series I and 13.6% in series II. For AEF patients, mortality was 37% in series I and 50% in series II. Among hospital survivors, infection-related late mortality was 13.5% in series I and 5% in series II. For AEF patients, late mortality was 20% in series I and 50% in series II. Incidence of reoperations was 54% in series I and 10.5% in series II (p<0.01). Hospital stay was 47.2+/-26.4 days in series I and 16.6+/-11.5 days in series II (p<0.001). CONCLUSIONS: compared to conventional treatment, incidence of reoperations and length of hospital stay are significantly decreased after cryopreserved allograft implantation. However, closure of aortic stump and extra-anatomic bypass gives better results for patients with AEF. [less ▲]

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See detailFinite element modeling of an electrostatic painting device
Deliège, Geoffrey ULiege; Henrotte, François; Hameyer, Kay

in IEEE Transactions on Magnetics (2003), 39(3), 1432-1435

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See detailSpatial distribution and morphological characteristics of the trunk lateral line neuromasts of the sea bass (Dicentrarchus labrax, L.; Teleostei, Serranidae).
Faucher, Karine ULiege; Aubert, Anne; Lagardère, Jean-Paul

in Brain, Behavior & Evolution (2003), 62(4), 223-32

The morphology and spatial distribution of the different types of neuromasts encountered on the trunk lateral line of the sea bass (Dicentrarchus labrax) were examined using scanning electron microscopy ... [more ▼]

The morphology and spatial distribution of the different types of neuromasts encountered on the trunk lateral line of the sea bass (Dicentrarchus labrax) were examined using scanning electron microscopy. The sea bass trunk lateral line exhibits a complete straight pattern. In their basic features, the two types of neuromasts present, canal and superficial, resemble what has been described in other fishes. They are similar in their general cellular organization but differ in sizes, and shapes, as well as in the densities and lengths of their hair bundles. However, the sea bass trunk lateral line distinguishes itself in several ways. For instance, the pores of the canal segments are partially obstructed due to the overlap of scales throughout the trunk. Moreover, based on the density and length of the hair bundles, two distinct areas, central and peripheral, could be distinguished within the maculae of canal neuromasts. Their cupulae are also peculiar as they possess two wing-like extensions and that their central core appears to be organized in layers instead of columns. In addition, the superficial neuromasts, up to 6 per scale, are either round or elliptical and seem to be distributed serendipitously. Finally, within the maculae of both types of neuromasts, a significant number of hair bundles do not follow the two-directional polarity pattern usually described. Although some hypotheses are proposed, the influence of these characteristics in terms of signal encoding and fish behavior is yet to be understood. [less ▲]

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See detailSkin immune dowregulators: from bench to bedside.
Pierard, Gérald ULiege; Franchimont, Claudine ULiege

in Current Topics in Pharmacology (2003), 7

New generations of topical skin immune downregulators (SIDRs) were recently introduced as an alternative to glucocorticoids for the topical treatment of some inflammatory dermatoses. Tacrolimus ... [more ▼]

New generations of topical skin immune downregulators (SIDRs) were recently introduced as an alternative to glucocorticoids for the topical treatment of some inflammatory dermatoses. Tacrolimus, pimecrolimus, sirolimus and dunaimycins inhibit the transcription of proinflammatory cytokine genes through binding to specific immunophilins. Taken together, SIDRs are able to inhibit a number of pro-inflammatory mediator systems and inflammatory cells with major importance for several cutaneous dermatitides. Therefore this group of compounds targeted dermatological diseases from the beginning of drug development. Several clinical trials have demonstrated the efficacy of tacrolimus and pimecrolimus in treating moderate to severe atopic dermatitis. Psoriasis, contact dermatitis and other dermatoses could also be indications for SIDRs. This review presents the cell biology changes and the mode of action of SIDRs. Their pharmacokinetics, clinical results and site effects are compared. [less ▲]

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See detailAu delà de l’irrationalité : vers une psychologique du phénomène de harcèlement moral.
Geuzaine, Caroline; Faulx, Daniel ULiege

in Cahiers Internationaux de Psychologie Sociale (2003), 48

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble ... [more ▼]

De prime abord, les situations de harcèlement moral dégagent une impression d’irrationalité intense (Geuzaine & Faulx, 2000). Depuis notre position d’observateur extérieur, nous sommes face à un ensemble d’éléments qui heurtent la logique. Du point de vue de celui qui s’en sent victime, d’abord : une personne vit une situation d’abus sur son lieu de travail, elle nous décrit, dans un flot de détails, les agissements qu’elle subit et nous percevons l’intensité de son angoisse. Les affects sont à l’avant-plan, intenses et souvent désespérés. La personne se sent persécutée, bafouée, démolie, et pourtant tente obstinément de continuer à fonctionner dans une situation insupportable. Pourquoi ? Du point de vue de l’organisation, ensuite : le harcèlement moral, entre autres conséquences dommageables, entrave la productivité, augmente l’absentéisme, génère des surcoûts importants et détériore la qualité des produits et des services. Si un fonctionnement optimal et une bonne gestion des ressources humaines semblent un objectif profitable à l’organisation, comment le harcèlement moral peut-il s’y développer ? Lorsque l’on tente d’intégrer le « harceleur» au système compréhensif, l’irrationnel est de nouveau à l’avant-plan. En effet, les raisons qui amènent cette personne à développer un mode relationnel persécutoire ont beau être logiquement justifiées (« je veille à la qualité du travail et promeus l’excellence ». «cette personne ne répond pas aux critères », « c’est de mon devoir de la sanctionner ,«c’est pour qu’elle apprenne »), il n’en sert pas moins, même involontairement, des fins totalement irrationnelles : mettre en échec puis détruire psychologiquement une personne et l’évacuer du système professionnel en invoquant sa propre responsabilité, son déséquilibre, son inadaptation au travail. Pourquoi ? Le but de cet article est de présenter un modèle d’analyse qui permette de dépasser l’impression d’irrationalité qui se dégage des situations de harcèlement moral. Nous verrons qu’il existe une logique sous-jacente au processus de harcèlement moral; logique certes subjective et biaisée, mais à la base d’un système de comportements et d’attentes très influent. Après avoir exposé quelques repères théoriques, nous présenterons notre recherche et nos postulats méthodologiques. La partie consacrée à nos résultats s’articulera autour de deux axes : la présentation de certaines régularités parmi les situations de harcèlement moral et une réflexion sur l’aide que l’on peut proposer aux personnes qui en sont victimes. [less ▲]

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See detailCompte rendu de l'ouvrage de S. Dawans : Le spectre de la honte
Cormann, Grégory ULiege

in Archives de Philosophie (2003), 66(2), 340-342

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See detailBelgium's immigration Policy
Martiniello, Marco ULiege

in International Migration Review (2003), 37(1), 225-232

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See detailPrédiction de la composition de la carcasse et de la qualité de viande du Piétrain stress négatif par ultrasonographie en temps réel
Youssao, A. K. I.; Verleyen, Vincent ULiege; Michaux, Charles ULiege et al

in Annales de Médecine Vétérinaire (2003), 147(6), 403-410

The lean meat proportion and longissimus thoracis intramuscular fat percentage were predicted in negative-stress Pietrain pigs by real-time ultrasound using Pie Medical 200. The optimal probing site for ... [more ▼]

The lean meat proportion and longissimus thoracis intramuscular fat percentage were predicted in negative-stress Pietrain pigs by real-time ultrasound using Pie Medical 200. The optimal probing site for the estimation of carcass lean content percentage was first identified. The models for the prediction of carcass lean content proportion by ultrasound measurement were developed. Comparisons between Fat Lean Meter, ultrasonic device Piglog 105 and Pie Medical 200 were made for lean meat proportion estimation in Pietrain carcasses. The intramuscular fat percentage was predicted from the white pixel percentage in the longissimus thoracis ultrasound image [less ▲]

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See detail3D h-phi finite element formulation for the computation of a linear transverse flux actuator
Deliège, Geoffrey ULiege; Henrotte, François; Vande Sande, Hans et al

in COMPEL (2003), 22(4), 1077-1088

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See detailLe japonisme en Belgique. L’affiche Art nouveau et l’estampe ukiyo-e
Bawin, Julie ULiege

in Bulletin de la Classe des Beaux-Arts (2003), XIV

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See detailBarotrauma-induced tension pneumoperitoneum.
Canivet, Jean-Luc ULiege; Yans, Th; Piret, Sonia ULiege et al

in Acta Anaesthesiologica Belgica (2003), 54(3), 233-6

We report the case of a massive tension-pneumoperitoneum developing immediately after starting mechanical ventilation (barotrauma). Careful analysis of CT-data provided meaningful informations in ... [more ▼]

We report the case of a massive tension-pneumoperitoneum developing immediately after starting mechanical ventilation (barotrauma). Careful analysis of CT-data provided meaningful informations in assessing the non surgical pulmonary source of pneumo peritoneum. [less ▲]

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See detailLack of trans-activation function for Maedi Visna virus and Caprine arthritis encephalitis virus Tat proteins
Villet, S.; Faure, C.; Bouzar, Amel ULiege et al

in Virology (2003)

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See detailFinding the lost Iris sofarana Foster
Saad, Layla ULiege

in Aril Society International Yearbook (2003)

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See detailCarbon dioxide daily variations and atmospheric fluxes over the Great Bahama Bank using a novel autonomous measuring system
Frankignoulle, Michel; Biondo, Renzo ULiege; Théate, Jean-Marie et al

in Caribbean Journal of Sience (2003), 39(3), 257-264

A novel autonomous measuring device that acquires the partial pressure of CO2 (pCO2) by equilibration and several other parameters is described. This device, the Floating Equilibrator System (FES) was ... [more ▼]

A novel autonomous measuring device that acquires the partial pressure of CO2 (pCO2) by equilibration and several other parameters is described. This device, the Floating Equilibrator System (FES) was tested in field conditions for the first time in the Great Bahama Bank, in December 2000. We successfully carried out two 24 h cycles in Norman’s Pond, one in front of the Caribbean Marine Research Centre (CMRC) and another one near Bock Cay. Over-saturation of CO2 with respect to atmospheric equilibrium was observed systematically at the three sites, although significantly more marked at Norman’s Pond. The higher values of pCO2 and atmospheric CO2 fluxes obtained at Norman’s Pond, than in the adjacent open waters of the Great Bahama Bank, suggest a comparatively stronger heterotrophy at Norman’s Pond. This is most likely related to the organic carbon inputs to the water column and sediments from the dense mangrove forest surrounding Norman’s Pond. The larger amplitude of pCO2 daily variations observed, during the Norman’s Pond 24 h cycles, is probably due to higher biological activity than in the adjacent open waters of the Great Bahama Bank. This is corroborated by a tentative estimation of Gross Primary Production based on simple computations. We speculate that calcification could also contribute to some extent to different amplitude of the pCO2 daily variations between the mangrove pond and the open waters of the Great Bahama Bank. [less ▲]

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See detailSymetrie et reproductibilite temporelle des donnees neurographiques.
Bouquiaux, Olivier ULiege; Horward, A.; Wang, François-Charles ULiege

in Neurophysiologie Clinique = Clinical Neurophysiology (2003), 33(4), 185-95

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected ... [more ▼]

The aims of the present study are to document side-to-side differences and temporal variability, between two trials (T1 and T2 at a time interval of 3 months) of nerve conduction measurements collected from 30 healthy subjects (mean age 22 +/- 2 years). METHODS: The protocol at T1 consisted of motor nerve conduction studies of median, ulnar, peroneal and tibial nerves bilaterally, with measurement of (a) motor response size (amplitude and area); (b) terminal latency; (c) minimal, mean and maximal F-wave latency; (d) motor conduction velocity; and (e) F-wave occurrence. T1 also involved sensory nerve conduction studies of median, ulnar, radial, lateral and medial cutaneous, sural and superficial peroneal nerves bilaterally, with measurement of sensory potential size (amplitude and area) and computation of sensory conduction velocity. The protocol at T2 consisted of identical measurements from the dominant side. RESULTS AND CONCLUSION: There was a negative relationship between the variability of parameters evaluating nervous conduction and the length of the nerve segment under study. Thus, the smallest side-to-side and temporal variabilities are measured for minimal F-wave latencies (on average 2-3%). The limits of symmetry and temporal variability are particularly useful for diagnosis of unilateral peripheral neuropathy or neurophysiological follow-up of patients with neuropathy, when the variability of the parameter under study is weak and when there is a high correlation between values recorded on the left and on the right or at T1 and T2. This was the case for motor response size of tibial and ulnar nerves, sensory potential size of radial nerve and minimal F-wave latencies from each studied motor nerve. [less ▲]

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See detailPara-Adrenal Adrenal Pseudocyst
Milicevic, Mladen ULiege; Dondelinger, Robert ULiege; Detry, Olivier ULiege

in JBR-BTR : Journal Belge de Radiologie - Belgisch Tijdschrift voor Radiologie (2003), 86(3, May-Jun), 166-7

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See detailThe Sahelian drought may have ended during the 1990s
Ozer, Pierre ULiege; Erpicum, Michel ULiege; Demarée, Gaston et al

in Hydrological Sciences Journal = Journal des Sciences Hydrologiques (2003), 48(3), 489-492

The severe drought that affects the Sahel since the late 1960s has been very closely studied and monitored during the last three decades. Recently, after several wet years, it was questioned from a ... [more ▼]

The severe drought that affects the Sahel since the late 1960s has been very closely studied and monitored during the last three decades. Recently, after several wet years, it was questioned from a statistical point of view whether the drought was over. The conclusions of a recent study were that the rainfall deficit was not over at the end of 2000 and that the drought continues. The analysis of the change points in the station rainfall time series suggests differentiating these findings. There is now growing evidence that there is a potential shift towards a more humid state. However, the present analysis shows that the assumption that a significant increase in rainfall may have occurred around the early 1990s could only be verified at the customary confidence level in about 10 years from now. [less ▲]

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See detailCAPRINE ARTHRITIS ENCEPHALITIS VIRUS (CAEV) EXPRESSING THE SIV VPR/VPX GENES INDUCES PROPERTIES SIMILAR TO ANTI-CANCER DRUGS
Bouzar, Amel ULiege; Villet, Stéphanie; Morin, Thierry et al

in Bulletin of the Veterinary Institute in Pulawy =Biuletyn Instytutu Weterynarii w Puławach (2003)

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See detailEvaluation des risques biomécaniques pour la colonne lombaire au moyen d'un questionnaire
Somville, Pierre-René ULiege; Mairiaux, Philippe ULiege

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2003), 40(1), 5-17

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See detailIsolation and partial characterization of three pregnancy-associated glycoproteins from the ewe placenta
El Amiri, B.; Remy, Benoit; Melo de Sousa, Noelita ULiege et al

in Molecular Reproduction and Development (2003), 64(2), 199-206

Pregnancy-associated glycoproteins (PAGs) are synthesized in the outer epithelial layer of the placenta in artiodactyls. In this work, three novel ovine PAGs were isolated from late-pregnancy fetal ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) are synthesized in the outer epithelial layer of the placenta in artiodactyls. In this work, three novel ovine PAGs were isolated from late-pregnancy fetal cotyledons and characterized biochemically. The isolation procedure included acid and ammonium sulfate precipitations and anion and cation exchange chromatographies. The isolated PAGs have different NH2-terminal amino acid sequences (RGSXLTILPLRNMRDIVY, ISRVSXLTIHPLRNIMDML, and RGSNLTIHPLRNIRD) and apparent molecular masses (55, 57, and 59 kDa). Each shows several isoforms with different pl values. The three proteins share high sequence identity with each other and with other ovine, bovine, and caprine PAGs. They have not been described previously. The ovPAG-59 sequence differs from the previously identified ovPAG-4 sequence (determined by DNA cloning and sequencing) at only one position among the 15 N-terminal residues. The newly characterized ovPAGs and the procedure used to isolate them will be helpful in producing new antisera for investigating PAG secretion in pregnant ewes. [less ▲]

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See detailP2X1-mediated ERK2 activation amplifies the collagen-induced platelet secretion by enhancing myosin light chain kinase activation.
Oury, Cécile ULiege; Toth-Zsamboki, Emese; Cornelissen, Heidi et al

in Journal of Biological Chemistry (2003)

This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated ... [more ▼]

This study shows that, at low doses of collagen, glycoprotein VI activation leads to early protein kinase C- and MLC kinase-dependent platelet degranulation. Rapidly released ATP triggers P2X1 -mediated Ca2+ influx, activating ERK2, in turn amplifying platelet secretion by reinforcing the early MLC kinase phosphorylation. Hence, the P2X1-ERK2-MLC axis contributes to collagen-induced platelet activation by enhancing platelet degranulation. [less ▲]

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See detailDevelopment Of Real-Time Pcr For The Rapid Detection Of Episomal Banana Streak Virus (Bsv)
Delanoy, Martine; Salmon, Marc ULiege; Kummert, Jean et al

in Plant Disease (2003), 87(1), 33-38

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See detailLiège-Paris 1848 : Littérature, féminisme et Révolution
Droixhe, Daniel ULiege

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2003), LXXXI(1-2), 41-49

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See detailOntogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents
Tirelli, Ezio ULiege; Laviola, Giovanni; Adriani, Walter

in Neuroscience & Biobehavioral Reviews (2003), 27(1-2), 163-178

The present review deals mainly with the ontogenesis of two important phenomena involved in vulnerability to several neuropsychiatric disorders, namely with drug-induced sensitization (both contextual and ... [more ▼]

The present review deals mainly with the ontogenesis of two important phenomena involved in vulnerability to several neuropsychiatric disorders, namely with drug-induced sensitization (both contextual and non-contextual) and with conditioned place preference. The term 'infancy' covers the first three postnatal weeks during development in rats and mice. Conversely, the term 'adolescence' may cover the whole postnatal period ranging from weaning (PND 21) to adulthood (at least PND 60) or specifically the period around the onset of puberty (animals aged 33-44 days). Recent studies in rats demonstrated that the establishment of a context-dependent sensitization appears during the first (for repeated drug administration) or during the second (for a single drug administration) postnatal week. However, the memory of drug-context association is transient in developing pups (lasting one or two days following the drug pretreatment). The long-term retention of drug-context associations matures progressively, and is complete by the third week of postnatal life. Finally, those mechanisms responsible for an adult-like profile of context-independent pharmacological sensitization appear later during ontogenesis, being mature by the fourth week of postnatal life. Another set of experiments extended this ontogenetic characterization by comparing adolescent and adult mice. When compared to the latter, the former subjects exhibit a greater amphetamine-induced locomotor sensitization, almost no sensitization of aversive stereotyped behaviors, and a less marked place conditioning. The strength of the drug-induced place conditioning was also directly compared with the unconditioned novelty-seeking drive. In conclusion, neonatal rats are able to show a relatively short-lasting retention of sensitized drug effects (short-term sensitization), whereas the ability to exhibit relatively long-lasting sensitized effects matures progressively during infancy (long-term sensitization). On the other hand, adolescent mice show a reduced sensitization of drug-induced psychotic symptoms, together with a more marked sensitization of arousing and euphorigenic properties of the drug and a reduced incentive memory of its hedonic effects. These age-related changes do imply very different degrees of vulnerability to drug addiction and several other neuropsychiatric disorders. (C) 2003 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailChanging Patterns of Political Participation of Citizens of Immigrant Origin in the Brussels Capital Region. The October 2000 Elections
Martiniello, Marco ULiege; Rea, Andrea; Jacobs, Dirk

in Journal of International Migration & Integration (2003), 3(2), 201-221

The October 2000 elections did constitute a landmark for the political participation of immigrant origin citizens in the Brussels Capital Region. There was a remarkable increase of elected Belgian ... [more ▼]

The October 2000 elections did constitute a landmark for the political participation of immigrant origin citizens in the Brussels Capital Region. There was a remarkable increase of elected Belgian politicians of non-EU–mainly Moroccan–origin. In this contribution we want to discuss the changing patterns of political participation of immigrant origin citizens in the Brussels Capital Region as seen in the most recent local elections. We contextualize the electoral success of Turkish and (mainly) Moroccan politicians and the poor involvement of EU citizens in the recent elections. To this purpose, we also discuss the political situation in the bilingual region of Brussels, Belgian citizenship law and regulations for political participation of foreign residents. [less ▲]

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See detailL'etude clinique du mois. L'etude Steno-2: plaidoyer pour une prise en charge globale et intensive du patient diabetique de type 2.
Scheen, André ULiege; Estrella, F.

in Revue Médicale de Liège (2003), 58(2), 109-11

Cardiovascular morbidity is a major burden in patients with type 2 diabetes. The Steno-2 Study compared the effect of a targeted, intensified, multifactorial intervention (n = 80) with that of a ... [more ▼]

Cardiovascular morbidity is a major burden in patients with type 2 diabetes. The Steno-2 Study compared the effect of a targeted, intensified, multifactorial intervention (n = 80) with that of a conventional treatment (n = 80) on modifiable risk factors for cardiovascular disease in patients with type 2 diabetes and microalbuminuria. After a mean follow-up of 7.8 years, the risk of cardiovascular events was reduced by 53% in the intensive group, and the risk of microvascular events (nephropathy, retinopathy, autonomic neuropathy) by 58-63%. Thus, a target-driven, long-term, intensified intervention aimed at multiple risk factors should be recommended in patients with type 2 diabetes and microalbuminuria. [less ▲]

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See detailPathophysiology of type 2 diabetes.
Scheen, André ULiege

in Acta Clinica Belgica (2003), 58(6), 335-41

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and ... [more ▼]

Type 2 diabetes mellitus is a heterogeneous syndrome characterized by abnormalities in carbohydrate and fat metabolism. The causes of type 2 diabetes are multi-factorial and include both genetic and environmental elements that affect beta-cell function and tissue (muscle, liver, adipose tissue, pancreas) insulin sensitivity. Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both these factors play important roles. However, the mechanisms controlling the interplay of these two impairments are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes. A majority of individuals suffering from type 2 diabetes are obese, with central visceral adiposity. Therefore, the adipose tissue should play a crucial role in the pathogenesis of type 2 diabetes. Although the predominant paradigm used to explain this link is the portal/visceral hypothesis giving a key role in elevated non-esterified fatty acid concentrations, two new emerging paradigms are the ectopic fat storage syndrome (deposition of triglycerides in muscle, liver and pancreatic cells) and the adipose tissue as endocrine organ hypothesis (secretion of various adipocytokins, i.e. leptin, TNF-alpha, resistin, adiponectin, implicated in insulin resistance and possibly beta-cell dysfunction). These two paradigms constitute the framework for the study of the interplay between insulin resistance and beta-cell dysfunction in type 2 diabetes as well as between our obesogenic environment and diabetes risk in the next decade. [less ▲]

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See detailThe Portugal coastal counter current off NW Spain: new insights on its biogeochemical variability
Alvarez-Salgado, Xosé Antón; Figueiras, F. G.; Perez, F. F. et al

in Progress in Oceanography (2003), 56(2), 281-321

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the ... [more ▼]

Time series of wind-stress data, AVHRR and SeaWiFS satellite images, and in situ data from seven cruises are used to assemble a coherent picture of the hydrographic variability of the seas off the Northwest Iberian Peninsula from the onset (September-October) to the cessation (February-May) of the Portugal coastal counter current (PCCC). During this period the chemistry and the biology of the shelf, slope and ocean waters between 40degrees and 43degreesN have previously been undersampled. Novel information extracted from these observations relate to: 1. The most frequent modes of variability of the alongshore coastal winds, covering event, seasonal and long-term scales; 2. The conspicuous cycling between stratification and homogenisation observed in PCCC waters, which has key implications for the chemistry and biology of these waters; 3. The seasonal evolution of nitrite profiles in PCCC waters in relation to the stratification cycle; 4. The Redfield stoichiometry of the remineralisation of organic matter in Eastern North Atlantic Central Water (ENACW)-the water mass being transported by the PCCC; 5. The separation of coastal (mesotrophic) from PCCC (oligotrophic) planktonic populations by a downwelling front along the shelf, which oscillates to and fro across the shelf as a function of coastal wind intensity and continental runoff; and 6. The photosynthetic responses of the PCCC and coastal plankton populations to the changing stratification and light conditions from the onset to the cessation of the PCCC. [less ▲]

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See detailWithin-herd effects of age at test day and lactation stage on test-day yields
Bormann, J.; Wiggans, G. R.; Druet, Tom ULiege et al

in Journal of Dairy Science (2003), 86(11), 3765-3774

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve ... [more ▼]

Variance ratios were estimated for random within-herd effects of age at test day and lactation stage, on test-day yield and somatic cell score to determine whether including these effects would improve the accuracy of estimation. Test-day data starting with 1990 calvings for the entire US Jersey population and Holsteins from California, Pennsylvania, Wisconsin, and Texas were analyzed. Test-day yields were adjusted for across-herd effects using solutions from a regional analysis. Estimates of the relative variance ( fraction of total variance) due to within-herd age effects were small, indicating that regional adjustments for age were adequate. The relative variances for within-herd lactation stage were large enough to indicate that accuracy of genetic evaluations could be improved by including herd stage effects in the model for milk, fat, and protein, but not for somatic cell score. Because the within-herd lactation stage effect is assumed to be random, the effect is regressed toward the regional effects for small herds, but in large herds, lactation curves become herd specific. Model comparisons demonstrated the greater explanatory power of the model with a within-herd-stage effect as prediction error standard deviations were greater for the model without this effect. The benefit of the within-herd-stage effects was confirmed in a random regression model by comparing variance components from models with and without random within-herd regressions and through log-likelihood ratio tests. [less ▲]

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See detailAnalysis Of Accessible Surface Of Residues In Proteins
Lins, Laurence ULiege; Thomas, Annick ULiege; Brasseur, Robert ULiege

in Protein Science : A Publication of the Protein Society (2003), 12(7),

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See detailBiogeographical Observations On Four Scolytids (Coleoptera, Scolytidae) And One Lymexylonid (Coleoptera, Lymexylonidae) In Wallonia (Southern Belgium)
Henin, Jm.; Huart, O.; Rondeux, Jacques ULiege

in Belgian Journal of Zoology (2003), 133(2), 175-180

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999 ... [more ▼]

Following a very sudden, early and deep frost at the end of autumn 1998, the availability of weakened trees (mainly beech trees) reached very high levels in Southern Belgium in the spring of 1999. Consequently, the ambrosia beetles Trypodendron domesticum L. and T. signatum (Fabricius) (Coleoptera, Scolytidae) initiated outbreaks and, in 2000 and 2001, they heavily contributed to the depreciation of nearly 1,600,000 m3 of stem volume (to upper limit girth of 22 cm) in the natural regions of “Ardenne” and “Belgian Lorraine”. Because of the lack of biogeographical data on both insects, of their conspicuous aggressiveness towards apparently healthy trees and of the economic importance of the beech wood chain in Belgium, a large-scale survey was undertaken in 2001, in order to outline the range of both ambrosia beetles in Wallonia. To this effect, a network of 172 traps baited with ethanol was set up, attempting to cover the Walloon beech forest as representatively as possible. Two other scolytids and one lymexylonid were also frequently caught, which made it possible to outline their regional distribution too. Although the damage was limited to the Ardenne and Belgian Lorraine, T. domesticum and T. signatum are widespread throughout Wallonia. We discuss these results, their long-term validity, the secondary pest status of these insects and the need for a permanent monitoring of the major forest pest species and diseases. [less ▲]

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See detailLa possible modification de la procédure de révision de la Constitution belge
Behrendt, Christian ULiege

in Revue Française de Droit Constitutionnel (2003)

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new ... [more ▼]

The article examines the question whether it is appropriate to alter the current amendment procedure of the Belgian constitution. Furthermore, the articles enquires into the possible design of a new amendment procedure. [less ▲]

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See detailGraulichite-(Ce), a new arsenate mineral from the Stavelot Massif, Belgium
Hatert, Frédéric ULiege; Pasero, Marco; Fransolet, André-Mathieu ULiege et al

in European Journal of Mineralogy (2003), 15(4, JUL-AUG), 733-739

Graulichite-(Ce), ideally CeFe33+(AsO4)(2)(OH)(6), is a new mineral species from Hourt, Stavelot Massif, Belgium. It occurs in the most altered parts of a Devillian quartzite (Lower to Middle Cambrian ... [more ▼]

Graulichite-(Ce), ideally CeFe33+(AsO4)(2)(OH)(6), is a new mineral species from Hourt, Stavelot Massif, Belgium. It occurs in the most altered parts of a Devillian quartzite (Lower to Middle Cambrian), in close association with arsenopyrite, scorodite, mimetite, pharmacosiderite, and goethite. Graulichite-(Ce) forms 80 to 150 mum spherical aggregates of rhombohedral crystals, 50 to 80 mum length, which show the forms {10 (1) over bar2} and {10 (11) over bar}. The mineral is transparent and exhibits a light-green to brownish colour, with a resinous lustre. It is non-fluorescent and shows an irregular fracture, without any perceptible cleavage. The calculated density is 4.42 g/cm(3). Graulichite-(Ce) is uniaxial negative, with a mean refractive index close to 1.97(1) (lambda=590 nm), pleochroic from light green to yellowish. Electron microprobe analyses gave As2O5 31.20, P2O5 0.03, SO3 0.06, SiO2 0.03, Al2O3 3.09, Fe2O3 30.65, SrO 0.24, PbO 0.07, BaO 3.95, CaO 0.03, La2O3 2.26, Ce2O3 15.73, Nd2O3 2.08, H2O (calc.) 8.37, total 97.79 wt. %. The resulting empirical formula, calculated on the basis of 6 cations, is (Ce0.67Ba0.18La0.10Nd0.09Sr0.02)(Sigma1.06) (Fe2.683+Al0.42)(Sigma3.10)[(As(1.89)S(.001)square(0.10))(Sigma2.00)O-8][(OH)(5.57)(H2O)(0.43)](Sigma6.00). The single-crystal unit-cell parameters are a=7.288(2) and c=16.812(9) Angstrom, space group R (3) over barm. The seven strongest lines in the X-ray powder-diffraction pattern [d(in Angstrom)(I)(hkil)] are: 3.052(100)(11 (2) over bar3), 3.636(40)(11 (2) over bar0), 2.239(35)(10 (1) over bar7), 1.817(35)(22 (4) over bar0), 2.792(30)(0006), 5.906(25)(10 (1) over bar1), 1.968(25)(30 (3) over bar3). Graulichite-(Ce) is the iron analogue of arsenoflorencite-(Ce), and belongs to the crandallite mineral group, with the alunite-type structure. The crystal structure of graulichite-(Ce) has been refined, based on single-crystal X-ray diffraction data, to R=0.048. [less ▲]

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See detailToxicomanes: sevrage ultrarapide aux opiacés sous anesthésie générale au CHU de Liège
Pinto, Emmanuel ULiege; Reggers, Jean ULiege; Fuchs, S. et al

in Agenda Psychiatrie (L') (2003), 28

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See detailCell Handling, Membrane-Binding Properties, And Membrane-Penetration Modeling Approaches Of Pivampicillin And Phthalimidomethylampicillin, Two Basic Esters Of Ampicillin, In Comparison With Chloroquine And Azithromycin
Chanteux, H.; Paternotte, I.; Mingeot-Leclercq, Mp. et al

in Pharmaceutical Research (2003), 20(4), 624-31

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with ... [more ▼]

PURPOSE: The purpose of this work was to examine and understand the cellular pharmacokinetics of two basic esters of ampicillin, pivaloyloxymethyl (PIVA) and phthalimidomethyl (PIMA), in comparison with lysosomotropic drugs (chloroquine, azithromycin). METHODS: Cell culture studies (J774 macrophages) were undertaken to study uptake and release kinetics and to assess the influence of concentration, pH, proton ionophore (monensin), and MRP and P-gp inhibitors (probenecid, gemfibrozil, cyclosporin A, GF 120918). Equilibrium dialysis with liposomes were performed to directly asses the extent of drug binding to bilayers. Conformational analysis modeling of the drug penetration in bilayers was conducted to rationalize the experimental observations. RESULTS: PIVA and PIMA showed properties in almost complete contrast with those of chloroquine and azithromycin, i.e., fast apparent accumulation and fast release at 4 degrees C as well as at 37 degrees C, saturation of uptake (apparent Kd 40 microM), no influence of monensin, MRP, or P-gp inhibitors; tight binding to liposomes (Kd approx. 40 microM); and sharp increase in calculated free energy when forced in the hydrophobic domain. CONCLUSIONS: Although they are weak organic bases, PIVA and PIMA show none of the properties of lysosomotropic agents. We hypothesize that they remain locked onto the pericellular membrane and may never penetrate cells as such in significant amounts. [less ▲]

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See detailMultiscale texture characterization of wastewater sludges dried in a convective rig
Léonard, Angélique ULiege; Blacher, Silvia ULiege; Pirard, René ULiege et al

in Drying Technology (2003), 21(8), 1507-1526

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several ... [more ▼]

Secondary sludges from two different wastewater treatment plants are conditioned and dewatered in the same way before drying in a lab-scale convective rig at the same operating conditions. Several techniques are used to characterize the texture of the dried materials over a wide range of scales from nm up to mm. Texture and porosity of the dried products are studied by SEM imaging, nitrogen absorption isotherms (0.5 < d(p) < 50 nm), mercury porosimetry (7.5 nm < d(p) < 150 mum) and X-ray microtomography (spatial resolution= 41 mum). The image analysis of cross-sections reconstructed by microtomography also allows following shrinkage and textural evolution during drying. [less ▲]

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See detailCellular Uptake Of Antennapedia Penetratin Peptides Is A Two-Step Process In Which Phase Transfer Precedes A Tryptophan-Dependent Translocation
Dom, G.; Shaw-Jackson, C.; Matis, C. et al

in Nucleic Acids Research (2003), 31(2), 556-61

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha ... [more ▼]

Several homeodomains and homeodomain-containing proteins enter live cells through a receptor- and energy-independent mechanism. Translocation through biological membranes is conferred by the third alpha-helix of the homeodomain, also known as Penetratin. Biophysical studies demonstrate that entry of Penetratin into cells requires its binding to surface lipids but that binding and translocation are differentially affected by modifications of some physico-chemical properties of the peptide, like helical amphipathicity or net charge. This suggests that the plasma membrane lipid composition affects the internalization of Penetratin and that internalization requires both lipid binding and other specific properties. Using a phase transfer assay, it is shown that negatively charged lipids promote the transfer of Penetratin from a hydrophilic into a hydrophobic environment, probably through charge neutralization. Accordingly, transfer into a hydrophobic milieu can also be obtained in the absence of negatively charged lipids, by the addition of DNA oligonucleotides. Strikingly, phase transfer by charge neutralization was also observed with a variant peptide of same charge and hydrophobicity in which the tryptophan at position 6 was replaced by a phenylalanine. However, Penetratin, but not its mutant version, is internalized by live cells. This underscores that charge neutralization and phase transfer represent only a first step in the internalization process and that further crossing of a biological membrane necessitates the critical tryptophan residue at position 6. [less ▲]

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See detailCombined enzymatic hydrolysis and HPAEC method for simultaneous analysis of galacturonic acid and neutral sugars of pectin.
Garna, H.; Mabon, N.; Wathelet, Bernard ULiege et al

in Communications in Agricultural and Applied Biological Sciences (2003), 68(2 Pt A), 297-300

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See detailL'immersion linguistique dans l'enseignement fondamental en Communauté française de Belgique
Blondin, Christiane ULiege

in Journal de l'Immersion (2003), 25(2), 19-31

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See detailBiodiversity, molecular phylogeny, and trophodynamics of amphipod crustaceans in the Antarctic deep-sea
De Broyer, Claude; Dauby, Patrick ULiege; Nyssen, Fabienne et al

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailThe Tellnes ilmenite deposit (Rogaland, South Norway): magnetic and petrofabric evidence for emplacement of a Ti-enriched noritic crystal mush in a fracture zone
Diot, Hervé; Bolle, Olivier ULiege; Lambert, Jean-Marc et al

in Journal of Structural Geology (2003), 25(4), 481-501

The Tellnes ilmenite deposit, a world class titanium deposit, occurs in the Ana-Sira anorthosite (Rogaland anorthosite province, South Norway). It is mainly made up of an ilmenite-rich norite that has ... [more ▼]

The Tellnes ilmenite deposit, a world class titanium deposit, occurs in the Ana-Sira anorthosite (Rogaland anorthosite province, South Norway). It is mainly made up of an ilmenite-rich norite that has been previously interpreted as injected in a crystal mush state, in a weakness zone of the enclosing anorthosite. This emplacement mechanism has produced a faint orientation in the ore due to the flow of the mush. The internal flow structure of the orebody is studied here using the low-field anisotropy of magnetic susceptibility (AMS) method. Partial anhysteretic remanent magnetization (pAARM) indicates that coarse magnetite is the main mineral responsible for the magnetic fabric. Parallelism of the magnetic fabric with the shape-preferred orientation of the ore-forming minerals is checked using image analysis (IA) from oriented sections (intercept method). Interpretation of the AMS data verified by pAARM and IA, provides information on the magmatic foliation and lineation. Emplacement flow of the ilmenite norite crystal mush occurred in the direction of the orebody, parallel to its walls, and with an average SE 18degrees plunge. The feeder zone was likely situated below a network of veins on the SE end of the orebody. The sickle-shaped outcrop of the deposit suggests a transcurrent, dextral opening of a WNW-ESE-striking weakness zone across the anorthosite pluton. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailResearching and teaching in the field of ethnic and racial studies : A view from continental Europe
Martiniello, Marco ULiege

in Ethnic and Racial Studies (2003), 26(3), 537-545

In the first part of the article, I make a few general comments inspired by the reading of Banton's article. I claim that the field of ethnic and racial studies is often dominated by an "Anglo ... [more ▼]

In the first part of the article, I make a few general comments inspired by the reading of Banton's article. I claim that the field of ethnic and racial studies is often dominated by an "Anglo-Americentric" vision that leads to a negation of the variety of approaches to ethnic and racial studies throughout the world. I claim that a process of "decentration" is necessary in order to foster the diversity in our field. In the second part of the article, I make specific comments inspired by my experience as researcher and teacher in a fragmented society such as Belgium. One conclusion is that our teaching has to be contextualized in order to avoid misunderstandings and the reproduction of inadequate conceptions and confusions about ethnic and racial issues among our students. [less ▲]

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See detailThe course of some bone remodelling plasma metabolites in healthy horses and in horses offered a calcium-deficient diet.
de Behr, V.; Daron, D.; Gabriel, Annick ULiege et al

in Journal of Animal Physiology & Animal Nutrition (2003), 87(3-4), 149-59

An inquiry was carried out to assess the concentrations of plasma metabolites related to bone remodelling in 21 saddle horses of Warmblood breed aged 4-26 years, five draught horses of Ardennes breed aged ... [more ▼]

An inquiry was carried out to assess the concentrations of plasma metabolites related to bone remodelling in 21 saddle horses of Warmblood breed aged 4-26 years, five draught horses of Ardennes breed aged 4-10 years, and 10 Ardennes foals aged 9-11 months. They were fed according to normal feeding practice in Belgium. The changes in some bone remodelling plasma metabolite concentrations were studied when an unbalanced diet was offered and later corrected for four Warmblood horses. Bone formation was evaluated by bone alkaline phosphatase (BALP), total alkaline phosphatase (TALP) and osteocalcin (bone gla-protein, OC). Bone resorption was assessed by hydroxyproline (HYP). Total calcium, ionized calcium, phosphorus (P) and 25-hydroxyvitamin D3 [25-(OH)D] concentrations were more or less constant. The comparison of four bone remodelling factors between the Ardennes and Warmblood horses showed higher concentrations in the Ardennes breed. Bone marker concentrations decreased according to age. The correction of the unbalanced Ca : P diet induced inconsistent effects at plasma level. The interpretation of the different bone parameters appeared to be difficult if not associated with other parameters such as a complete anamnesis and clinical examination of the animal in addition to dietary evaluation. [less ▲]

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See detailCTD measurements, with emphasis on Elephant Island surroundings
Dauby, Patrick ULiege

in Berichte zur Polar- und Meeresforschung (2003), 470

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See detailDiurnal Centroid Of Ecosystem Energy And Carbon Fluxes At Fluxnet Sites
Wilson, Kb.; Baldocchi, D.; Falge, E. et al

in Journal of Geophysical Research. Atmospheres (2003), 108(D21),

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See detailStratégies de fusion d’images P/XS basées sur les principes colorimétriques et l’Egalisation de Statistiques Locales
Cornet, Yves ULiege; Schenke, Christophe ULiege; De Bethune, S. et al

in Bulletin de la Société Française de Photogrammétrie et Télédétection (2003), 169

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See detailEnfin "Tubambe" devoile son identite! Hadraphe ethiopica (Bethune-Baker) (Limacodidae), une chenille comestible des forets claires zambeziennes.
Malaisse, François ULiege; Demesmaecker, Anne; Matera, Joseph et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2003), 7(2), 67-77

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été ... [more ▼]

La consommation humaine de chenilles de Limacodidae avait été signalée en Afrique centro-australe. L’une de ces espèces, Hadraphe ethiopica, a été déterminée. Des données relatives à sa biologie ont été rassemblées. Des analyses d’échantillons séchés ont permis de préciser leur composition chimique et leur valeur nutritionnelle, notamment sur le plan des acides aminés et des acides gras. [less ▲]

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See detailImproved rank-based dependence measures for categorical data
Vandenhende, François; Lambert, Philippe ULiege

in Statistics & Probability Letters (2003), 63

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for ... [more ▼]

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for dependence models using copulas. [less ▲]

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See detailHorizontal And Vertical Co2 Advection In A Sloping Forest
Aubinet, Marc ULiege; Heinesch, Bernard ULiege; Yernaux, Michel ULiege

in Boundary-Layer Meteorology (2003), 108(3),

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See detailHigh-Performance Liquid Chromatography Analyses Of Pyoverdin Siderophores Differentiate Among Phytopathogenic Fluorescent Pseudomonas Species
Bultreys, Alain; Gheysen, Isabelle; Wathelet, Bernard ULiege et al

in Applied and Environmental Microbiology (2003), 69(2),

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See detailEffets du protocole GPG sur l’activité ovarienne
Hanzen, Christian ULiege; Boudry, B.; Drion, Pierre ULiege

in Point Vétérinaire (2003), 34(237), 26-30

The GPG protocol or OvSynch includes an injection of GnRH and followed seven days later by an injection of PgF(2alpha), which is preceded forty-eight hours earlier by a second injection of GnRH. The ... [more ▼]

The GPG protocol or OvSynch includes an injection of GnRH and followed seven days later by an injection of PgF(2alpha), which is preceded forty-eight hours earlier by a second injection of GnRH. The effects of GnRH on follicular tissue are either ovulation or luteinization depending at which stage of the cycle the cow is injected i.e. metoestrus, dioestrus or end of dioestrus. Observation of one or the other effect suggests a close association between the stage of follicular development, the function of the follicular tissue present and also the concentration of progesterone. [less ▲]

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See detailMéthodologie des plans de gestion piscicole en Région wallonne, application au bassin de la Semois
Conjaerts, C.; Hauptmann, Y.; Waltzing, D. et al

in Pêcheur Belge (Le) (2003), (8), 22-25

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See detailPhysical and textural characteristics of hydrogenated low-erucic acid rapeseed oil and low-erucic acid rapeseed oil blends
Danthine, Sabine ULiege; Deroanne, Claude ULiege

in Journal of the American Oil Chemists' Society (2003), 80(2), 109-114

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat ... [more ▼]

Low-erucic acid rapeseed oil (LERO) and hydrogenated low-erucic acid rapeseed oil (HLERO) were blended in binary systems. The blends were then studied for their physical properties such as solid fat content, melting curves by DSC, textural properties, and polymorphism. Phase behavior diagrams were constructed from the DSC and X-ray results, and isosolid diagrams were constructed from the NMR results. The mixture of HLERO and LERO displayed a monotectic behavior for all the storage time at 15degreesC. The aim of this work was to evaluate physical characteristics of binary blends of HLERO and nonhydrogenated LERO in order to use only LERO and hardened LERO in bakery shortenings. The mixture of 60% HLERO and 40% LERO is suitable to use as a plastic shortening, This blend is beta tending upon storage at 15degreesC. It could be used in pie crust applications. [less ▲]

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See detailEvaluation of thyroid function in obese dogs and in dogs undergoing a weight loss protocol
Daminet, Sylvie; Jeusette, Isabelle; Duchateau, L. et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (2003), 50(4), 213-218

Obesity and weight loss have been shown to alter thyroid hormone homeostasis in humans. In dogs, obesity is the most common nutritional problem encountered and weight loss is the cornerstone of its ... [more ▼]

Obesity and weight loss have been shown to alter thyroid hormone homeostasis in humans. In dogs, obesity is the most common nutritional problem encountered and weight loss is the cornerstone of its treatment. Therefore, it is important to clarify how obesity and weight loss can affect thyroid function test results in that species. The objectives of this study were to compare thyroid function in obese dogs and in lean dogs and to explore the effects of caloric restriction and weight loss on thyroid hormone serum concentrations in obese dogs. In the first experiment, 12 healthy lean beagles and 12 obese beagles were compared. Thyroid function was evaluated by measuring serum concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), thyrotropin (TSH), and reverse triiodothyronine (rT3) as well as a TSH stimulation test using 75 mu g IV of recombinant human TSH. In the second experiment, eight obese beagles were fed an energy-restricted diet [average 63% maintenance energy requirement (MER)] until optimal weight was obtained. Blood samples for determination of TT4, FT4, TT3, TSH and rT3, were taken at the start and then weekly during weight loss. Only TT3 and TT4 serum concentrations were significantly higher in obese dogs as compared to lean dogs. In the second experiment, weight loss resulted in a significant decrease in TT3 and TSH serum concentrations. Thus obesity and energy restriction significantly alter thyroid homeostasis in dogs, but the observed changes are unlikely to affect interpretation of thyroid function test results in clinics. [less ▲]

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See detailDéveloppement de modèles prédictifs des proportions de duramen et d'écorce des espèces de mélèze cultivées en zones de basse altitude en Europe de l'Ouest (Larix kaempferi (Lambert) Carr., Larix decidua Miller et Larix eurolepis Henry).
Pauwels, D.; Lejeune, Philippe ULiege; Paques, L. E. et al

in Annals of Forest Science : a Multidisciplinary and International Journal (2003), 60(3), 227-235

Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way ... [more ▼]

Predictive models for heartwood and bark proportions have been developed for Japanese larch (Larix kaempferi (Lambert) Carr.) planted in South of Belgium. These models have been tested to evaluate the way of applying them to European larch (Larix decidua Miller) and hybrid larch (Larix eurolepis Henry) growing in west-European lowlands. For the heartwood proportion, independent variables selected are stand age and dbh. The model set up for Japanese larch has a R-square of 0.859. In average, European larch has lower heartwood proportion. With reference to bark proportion, selected independent variable is dbh. Residual variability is far more important for bark models (R-square of 0.456). European larch has, in average, higher bark proportion whereas hybrid larch has lower. An example of the application of these models in connection with a growth model is presented. It consists in an evaluation of the impact of dynamic silviculture on heartwood and bark proportion. [less ▲]

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