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See detailComparison of visual and auditory evoked cortical potentials in migraine patients between attacks.
Afra, J.; Proietti Cecchini, A.; Sandor, P. S. et al

in Clinical Neurophysiology (2000), 111(6), 1124-9

OBJECTIVE: As both habituation of pattern reversal visual evoked potentials (PR-VEP) (Schoenen J, Wang W, Albert A, Delwaide PJ. Potentiation instead of habituation characterizes visual evoked potentials ... [more ▼]

OBJECTIVE: As both habituation of pattern reversal visual evoked potentials (PR-VEP) (Schoenen J, Wang W, Albert A, Delwaide PJ. Potentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks. Eur J Neurol 1995;2:115-122) and intensity dependence of auditory evoked cortical potentials (IDAP) (Wang W, Timsit-Berthier M, Schoenen J. Intensity dependence of auditory evoked potentials in migraine: an indication of cortical potentiation and low serotonergic neurotransmission? Neurology 1996;46:1404-1409) were found abnormal in migraine between attacks, we have searched for intraindividual correlations between both tests in 59 migraine patients (22 with aura [MA], 37 without aura [MO]) and in 23 healthy volunteers (HV). METHODS: Amplitude change of the PR-VEP N1-P1 was measured between the 1st and 5th block of 50 sequential averagings during continuous stimulation at 3.1 Hz. IDAP was computed from N1-P2 amplitudes of 100 averagings during stimulations at 40, 50, 60 and 70 dB SL. Amplitude-stimulus intensity function (ASF) slopes and amplitude changes between 40 and 70 dB were calculated. MO and MA differed from HV in PR-VEP amplitude change (P=0.007) and IDAP slope (P = 0.0004). RESULTS: There was no significant correlation between VEP amplitude changes and IDAP slopes, nor between the latter two and attack frequency or disease duration. A negative correlation was found between the amplitude of the first block of averaged responses and potentiation of VEP in all subject groups (P = 0.03) as well as between the amplitude of the auditory evoked potential, at 40 dB, and the percentage of amplitude increase between 40 and 70 dB in MO (P = 0.004) and MA (P = 0.007). ASF slopes and 40 dB amplitudes were significantly correlated only in the MA group (P = 0.002). These results confirm the interictal deficit of habituation in cortical processing of repetitive visual and auditory information in migraine. Since there is no intraindividual correlation between the cortical responses to these sensory modalities they are complementary tools for the study of migraine and may help to identify subgroups of patients with distinct pathophysiological mechanisms. CONCLUSIONS: The strong negative correlation between the initial amplitude of evoked potentials and their amplitude increase during subsequent averaging confirms that the response potentiation in migraine is likely to be due to a reduced preactivation level of sensory cortices. [less ▲]

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See detailLes spatiocartes d'occupation du sol
Binard, Marc ULg; Donnay, Jean-Paul ULg

in Bulletin de la Société Géographique de Liège (2000), 38(2000/1), 63-78

Les spatiocartes d'occupation du sol sont dérivées de la classification d'une ou plusieurs images satellite selon une nomenclature conventionnelle des affectations du sol. En importance, elles constituent ... [more ▼]

Les spatiocartes d'occupation du sol sont dérivées de la classification d'une ou plusieurs images satellite selon une nomenclature conventionnelle des affectations du sol. En importance, elles constituent sans doute le second type de spatiocartes le plus couramment produit, après les spatiocartes en composition colorée. Vis-à-vis de ces dernières, les spatiocartes d'occupation du sol relèvent cependant d'une toute autre logique et procèdent d'une méthodologie très différente. La composition colorée est conçue pour laisser au lecteur le soin d'interpréter l'image en fonction de ses propres centres d'intérêt, et les techniques sélectionnées pour son élaboration doivent précisément favoriser la reconnaissance et l'identification visuelle d'un maximum de détails. La spatiocarte d'occupation du sol, par contre, répond à un objectif précis et déterminé a priori. Tout, depuis la sélection des images sources jusqu'à la sélection des couleurs, en passant par le choix de l'échelle et la fixation de la nomenclature, est dicté par une thématique unique. Les méthodes de classification, elles-mêmes, ne sont pas indépendantes de l'objectif poursuivi. Le but de ce chapitre n'est pourtant pas de discourir sur les multiples algorithmes de classification des images. Une très volumineuse littérature, en constante évolution, y est consacrée (Atkinson & Lewis, 2000, Chin-Teng et al., 2000, Simpson et al., 2000). Les méthodes les plus traditionnelles, relevant de l'interprétation d'images assistée par ordinateur, co-existent avec les méthodes les plus récentes, telles les classifications par réseaux de neurones ou les classifications bayesiennes. L'utilisation de l'une ou l'autre méthode, voire de plusieurs en chaîne, se justifie à l'occasion de tel ou tel cas de figure mais elles n'interfèrent guère sur la préoccupation présente qui consiste à transformer une image classée en une carte. On conçoit dès lors que les traitements dont il sera question se situent en aval du processus de classification proprement dit. Quelques considérations seront pourtant émises sur les préalables de la classification et sur la nature et la qualité de l'image classée, dans la mesure où elles peuvent orienter l'élaboration de la spatiocarte. Par contre, les divers traitements relevant de l'habillage ou de l'impression, communs à toute spatiocarte quelle qu'en soit la facture, sont réservés à des chapitres ultérieurs. De même, quelques opérations complexes, susceptibles d'intervenir dans la réalisation de certaines spatiocartes de l'occupation du sol, mais exigeant un bagage méthodologique important, sont développées dans des chapitres spécifiques auxquels nous renverrons le moment venu. [less ▲]

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See detailEarly-stage endometriosis: adhesion and growth of human menstrual endometrium in nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Donnez, Jacques

in Fertility and Sterility (2000), 74(2), 306-12

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research ... [more ▼]

Objective: To evaluate the implantation of menstrual endometrium and the early stages of evolution of endometriotic lesions. Design: Experimental prospective study. Setting: An academic research environment. Animals: Ten nude mice. Intervention(s): A minilaparotomy was performed to place fresh human menstrual endometrial samples in the peritoneal cavity. Removal of the transplants was performed successively on days 1, 3, and 5 by laparotomy. Main Outcome Measure(s): Adhesion of endometrial fragments and early stages of endometrial lesions was morphologically and immunohistochemically studied. Result(s): As early as day 1, stromal cells were found to be attached to the mesothelium. A progressive reorganization of epithelial and stromal cells into endometrial glands was observed. On day 5, cystic endometriotic lesions were characterized by more extensive proliferative activity in glandular cells and a higher VEGF score in stromal cells than that observed in previously removed transplants. Conclusion(s): Menstrual human endometrium is able to implant on intact mesothelium and to reorganize itself into structured glands and stroma under the influence of unknown factors. We suggest that stromal and glandular cells have two distinct roles: stromal cells are involved in the attachment process and glandular cells in the growth of the endometriotic lesion. [less ▲]

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See detailGeneralization of automatic sequences for numeration systems on a regular language
Rigo, Michel ULg

in Theoretical Computer Science (2000), 244

Let L be an infinite regular language on a totally ordered alphabet (Σ,<). Feeding a finite deterministic automaton (with output) with the words of L, enumerated lexicographically with respect to <, leads ... [more ▼]

Let L be an infinite regular language on a totally ordered alphabet (Σ,<). Feeding a finite deterministic automaton (with output) with the words of L, enumerated lexicographically with respect to <, leads to an infinite sequence over the output alphabet of the automaton. This process generalizes the concept of k-automatic sequence for abstract numeration systems on a regular language (instead of systems in base k). Here, we study the first properties of these sequences and their relations with numeration systems. [less ▲]

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See detailLithics in Belgium. Some Current Research Trends
Rots, Veerle ULg; Vermeersch, Pierre

in Lithic Technology (2000), 25(2), 76-79

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See detailThe relationship between airways inflammation and asthma severity.
Louis, Renaud ULg; Lau, L. C.; Bron, A. O. et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(1), 9-16

In order to investigate the relationship between airways inflammation and disease severity, and improve the understanding of persistent asthma, 74 asthmatics, with disease severity ranging from ... [more ▼]

In order to investigate the relationship between airways inflammation and disease severity, and improve the understanding of persistent asthma, 74 asthmatics, with disease severity ranging from intermittent, to mild to moderate and severe persistent (classified according to the Global Initiative for Asthma [GINA] guidelines), and 22 nonatopic control subjects were studied using the method of induced sputum. Sputum was analyzed for total and differential cell counts concentrations of albumin, and levels of eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase, inflammatory mediators reflecting eosinophil, neutrophil, and mast cell activation. Asthma severity (assessed by FEV(1), peak expiratory flow [PEF] variability, and daily symptom scores) and methacholine airways responsiveness were related to sputum eosinophilia and ECP. In addition, sputum neutrophilia and MPO levels correlated, albeit weakly, with PEF variability and symptom scores, respectively. Tryptase concentrations were raised in mild to moderate asthmatics. Albumin concentrations were significantly raised across the spectrum of asthma severity and correlated with those of tryptase and ECP. Despite treatment with either high doses of inhaled corticosteroids or oral corticosteroids, prominent eosinophilic inflammation with raised ECP was noted. This study points to persistent, disease severity-related airways inflammation in asthma, involving eosinophils, mast cells, and neutrophils, which is evident despite treatment with corticosteroids. [less ▲]

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See detailIn vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR).
Mouithys-Mickalad, Ange ULg; Zheng, S. X.; Deby-Dupont, G. P. et al

in Free Radical Research (2000), 33(5), 607-21

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties ... [more ▼]

OBJECTIVES: To determine the antioxidant activities of nonsteroidal anti-inflammatory drugs (NSAIDS), we examined by chemiluminescence (CL) and electron spin resonance (ESR) their scavenging properties towards lipid peroxides, hypochlorous acid and peroxynitrite. METHODS: The antioxidant properties of nimesulide (NIM), 4-hydroxynimesulide (4-HONIM), aceclofenac (ACLO), 4-hydroxyaceclofenac (4-HOA-CLO), diclofenac (DICLO) and indomethacin (INDO) were tested on four different reactive oxygen species (ROS) generating systems: (I) phorbol-myristate acetate (PMA)-activated neutrophils, (II) Fe2+/ascorbate-induced lipid peroxidation, (III) HOCl-induced light emission, (IV) the kinetics of ONOO- decomposition followed by spectrophotometry. ROS production was monitored by luminol-enhanced CL or by ESR using two different spin traps. RESULTS: At 10 microM, ACLO, NIM, 4-HONIM, 4-HOA-CLO, and DICLO decreased luminol-enhanced CL generated by PMA-activated neutrophils. Inversely, INDO increased the luminol enhanced CL. Interestingly, hydroxylated metabolites were more potent antioxidants than the parent drugs. Furthermore, all drugs tested, excepted ACLO, lowered lipid peroxidation induced by Fe2+/ascorbate system. ACLO and DICLO, even at the highest concentration tested (100 microM), did not significantly lower HOCl induced CL, whereas the other drugs were potent scavengers. Finally, all the NSAIDS accelerated decomposition of ONOO-, suggesting a potential capacity of the molecules to scavenge peroxynitrite. CONCLUSION: The NSAIDs possess variable degrees of antioxidant activities, linked to their ability to react with HOCl, lipid peroxides or ONOO-. These antioxidant activities could offer interesting targeted side-effects in the treatment of joint inflammatory diseases. [less ▲]

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See detailHyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale ULg; Canivet, Jean-Luc ULg; Gennigens, Christine ULg et al

in Bone Marrow Transplantation (2000), 26(3), 343-5

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the ... [more ▼]

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma. [less ▲]

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See detailcompte rendu de : B. Liou-Gille, Une lecture "religieuse" de Tite-Live I. Cultes, rites, croyances de la Rome archaïque
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2000), 78(1), 241-244

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See detailSystemic Induction Of Phytoalexins In Cucumber In Response To Treatments With Fluorescent Pseudomonads
Ongena, MARC ULg; Daayf, F.; Jacques, Philippe ULg et al

in Plant Pathology (2000), 49(4),

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of ... [more ▼]

The Pseudomonas putida isolate BTP1 and its sid2 mutant M3 were recently reported to protect cucumber against Pythium aphanidermatum root rot. This protection was mainly associated with an accumulation of antifungal phenolics in the treated roots. In this study, analyses of root extracts from split-root experiments showed that these phytoalexins were produced systemically. Indeed, several antifungal molecules accumulated similarly in both treated and nontreated root parts of plants protected against P. aphanidermatum with BTP1 or M3. In addition, analyses of leaf samples also revealed increased amounts of fungitoxic molecules in PGPR-treated plants, although the nature of these molecules appeared to be different from those detected in roots. The antifungal compounds isolated both from roots and leaves were mainly detected in acid-hydrolyzed extracts containing aglycones. These results suggest that PGPR can elicit phytoalexins systemically in cucumber and that the overall defence response is not based on a single phytoalexin but is chemically complex and organ-specific. [less ▲]

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See detailcompte rendu de : Jacqueline Fabre-Serris, Mythologie et littérature à Rome. La réécriture des mythes aux Iers siècles avant et après J.-C.
Rochette, Bruno ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (2000), 13

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See detailLiège et Voltaire
Droixhe, Daniel ULg

in Bulletin de l'Académie Royale de Langue et de Littérature Françaises (2000), LXXVIII(1-2-3-4), 39-48

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See detailCalendes et calendriers: du temps cyclique au temps historique
Biémont, Emile ULg

in Ciel (Le) (2000), 62

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See detailLa probatio internetica
Vanbrabant, Bernard ULg

in Actualités du Droit (2000)

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See detailExport production in the Bay of Biscay as estimated from barium - barite in settling material: a comparison with new production
Dehairs, F.; Fagel, Nathalie ULg; Antia, A. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (2000), 47(4), 583-601

We present barium data for sediment traps deployed in a northeast Atlantic margin environment (Bay of Biscay). Fluxes of excess barium were measured with the objective of calculating carbon export ... [more ▼]

We present barium data for sediment traps deployed in a northeast Atlantic margin environment (Bay of Biscay). Fluxes of excess barium were measured with the objective of calculating carbon export production rates from the surface mixed layer and thus contribute to the understanding of organic carbon transport in a margin environment. Therefore, it was necessary to properly understand the different processes that affected the barium fluxes in this margin environment. Seasonal variability of POC/Ba flux ratios and decrease of barium solubilisation in the trap cups with increasing depth in the water column probably indicate that the efficiency of barite formation in the organic micro-environment varies with season and that the process is relatively slow and not yet completed in the upper 600 m of water column. Thus barite presence in biogenic aggregates will significantly depend on water column transit time of these aggregates. Furthermore, it was observed that significant lateral input of excess-Ba can occur, probably associated with residual currents leaving the margin. This advected excess-Ba affected especially the recorded fluxes in the deeper traps (>1000 m) of the outer slope region. We have attempted to correct for this advected excess-Ba component, using Th (reported by others for the same samples) as an indicator of enhanced lateral flux and assigning a characteristic Ba/Th ratio to advected material, Using transfer functions relating excess-Ba flux with export production characteristic of margin areas, observed Ba fluxes indicate an export production between 7 and 18 g C m(-2) yr(-1). Such values are 3-7 times lower than estimates based on N-nutrient uptake and nutrient mass balances, but larger and more realistic than is obtained when a transfer function characteristic of open ocean systems is applied. The discrepancy between export production estimates based on excess-Ba fluxes and nutrient uptake could be resolved if part of the carbon is exported as dissolved organic matter. Results suggest that margin systems function differently from open ocean systems, and therefore Ba-proxy rationales developed for open ocean sites might not be applicable in margin areas. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailInverse vegetation modelling : a tool to reconstruct palaeoclimates under changed CO2 conditions
Guiot, J.; Torre, F.; Jolly, D. et al

in Ecological Modelling (2000), 127

Atmospheric CO2 concentration has greatly fluctuated during the Quaternary. These variations have influenced the vegetation changes. The assumption that the relationship vegetation–climate sensu stricto ... [more ▼]

Atmospheric CO2 concentration has greatly fluctuated during the Quaternary. These variations have influenced the vegetation changes. The assumption that the relationship vegetation–climate sensu stricto was constant through time should be reconsidered taking into account the impact of the atmospheric CO2 content on the plants. Here we propose to use a process-based vegetation model (BIOME3) in an inverse mode to reconstruct from pollen data the most probable climate under precipitation seasonality change and under lowered CO2 concentration in the biosphere. Appropriate tools to match the model outputs with the pollen data are developed to generate a probability distribution associated with the reconstruction (Monte Carlo sampling and neural network techniques). The method is validated with modern pollen samples from Greece and Italy: it proves to be able to reconstruct modern climate with a more or less large error bar from pollen data. The error bar depends in fact on the tolerance of the vegetation to the corresponding climatic variable. The application to six pollen assemblages from Greece and Italy, representing the last glacial maximum (LGM: 18 000 14C-year B.P.), is done into three experiments: (1) modern CO2 concentration; (2) LGM CO2 concentration; (3) LGM CO2 concentration and high winter precipitation. The latter experiment is motivated by evidence of high lake-levels in Greece during the LGM which has been attributed to winter rainfall. These experiments show that winter was ca. 15–20°C colder than the present, in agreement with previous climate reconstruction. The apparent discrepancy between the high lake-levels and the steppe vegetation during the LGM, can be explained by an increase of the winter precipitation (which leads to high lake level) while the summer season is mild and dry (which affects the vegetation). The summer temperature has three stable states (−16°C, −10°C, −2°C), but the warmest one is the most probable if we take into account the lowered CO2 and the high lake-levels. [less ▲]

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See detailTissue distribution, autoradiography, and metabolism of 4-(2'-methoxyphenyl)-1-[2' -[N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethyl]piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: An In vivo study in rats.
Plenevaux, Alain ULg; Weissmann, D.; Aerts, Joël ULg et al

in Journal of Neurochemistry (2000), 75(2), 803-11

The in vivo behavior of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-[(18)F]fluorobenzamido ]ethyl]-piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist, was studied in awake, freely moving ... [more ▼]

The in vivo behavior of 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-[(18)F]fluorobenzamido ]ethyl]-piperazine (p-[(18)F]MPPF), a new serotonin 5-HT(1A) antagonist, was studied in awake, freely moving rats. Biodistribution studies showed that the carbon-fluorine bond was stable in vivo, that this compound was able to cross the blood-brain barrier, and that a general diffusion equilibrium could account for the availability of the tracer. The great quantity of highly polar metabolites found in plasma did not contribute to the small amounts of metabolites found in hippocampus, frontal cortex, and cerebellum. Exvivo p-[(18)F]MPPF and in vitro 8-hydroxy-2-(di-n-[(3)H]propylamino)tetralin autoradiography were compared both qualitatively and quantitatively. Qualitative evaluation proved that the same brain regions were labeled and that the p-[(18)F]MPPF labeling is (a) in total agreement with the known distribution of 5-HT(1A) receptors in rats and (b) characterized by very low nonspecific binding. Quantitative comparison demonstrated that the in vivo labeling pattern obtained with p-[(18)F]MPPF cannot be explained by differences in regional blood flow, capillary density, or permeability. The 5-HT(1A) specificity of p-[(18)F]MPPF and binding reversibility were confirmed in vivo with displacement experiments. Thus, this compound can be used to evaluate parameters characterizing 5-HT(1A) binding sites in the brain. [less ▲]

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See detailL'opération sources en Belgique : premières analyses statistiques des résultats et légitimité des cartes "nitrates".
Wattecamps, J. M.; Bernier, Jacques; De Backer, Louis et al

in Hydrological Sciences Journal = Journal des Sciences Hydrologiques (2000), 45(1), 43-60

L'opération sources du WWF (Worldwide Fund for Wildlife) est une action éducative de sensibilisation à la qualité des eaux souterraines. Elle implique principalement les élèves de cinquième et sixième ... [more ▼]

L'opération sources du WWF (Worldwide Fund for Wildlife) est une action éducative de sensibilisation à la qualité des eaux souterraines. Elle implique principalement les élèves de cinquième et sixième primaires de Belgique. Depuis 1994, des centaines de dosages des ions nitrates ont été effectués dans un grand nombre de sources et de puits à l'aide de bandelettes colorimétriques. A l'issue de chaque campagne, les points d'eau surveillés ont été reportés sur une carte de Belgique où leur couleur indique leur qualité eu égard à la concentration en nitrates. L'objectif pédagogique étant atteint, la validation de ces cartes en tant qu'image de la réalité pose le problème de la vérification du lien entre la concentration réelle (mg l-1) du point d'eau visité et sa couleur sur la carte. A cette fin, des vérifications ont été réalisées sur 308 points d'eau choisis au hasard dans l'ensemble des sources et puits visités. L'analyse statistique révèle que la relation entre le test colorimétrique et le contrôle réalisé en laboratoire est hautement significative. Ce résultat justifie des investigations ultérieures, notamment la mobilisation de l'information régionale pour la qualification d'un point d'eau peu surveillé et la comparaison des cartes dans le temps. [less ▲]

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See detailTEP et tumeurs endocrines
Rigo, Pierre ULg; Belhocine, Tarik; Hustinx, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2000), 24(5), 275-282

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les ... [more ▼]

Les auteurs passent en revue les indications de la TEP et en particulier du 18FDG dans l'évaluation des diverses tumeurs endocrines de la thyroïde, des parathyroïdes, des surrénales et de l'hyophyse. Les tumeurs neuroendocrines, gastroentéropancréatiques et carcinoïdes, sont également analysées. Habituellement, les tumeurs différenciées ayant une faible activité métabolique et proliférative, elles ne fixent que peu le FDG. Dans l'évaluation des tumeurs endocrines, la TEP au FDG n'intervient en général pas en première intention mais elle joue un rôle complémentaire d'autres scintigraphies spécifiques. [less ▲]

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See detailBactériologie comparée des liquides de lavage pulmonaire obtenus par voie transtrachéale ou par voie nasotrachéale chez le veau
Schreiber, P.; Thomas, A.; Linden, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailRandom matrix model for chiral symmetry breaking and color superconductivity in QCD at finite density
Vanderheyden, Benoît ULg; Jackson, A. D.

in Physical Review. D : Particles and Fields (2000), 62(9), 094010

We consider a random matrix model which describes the competition between chiral symmetry breaking and the formation of quark Cooper pairs in QCD at finite density. We study the evolution of the phase ... [more ▼]

We consider a random matrix model which describes the competition between chiral symmetry breaking and the formation of quark Cooper pairs in QCD at finite density. We study the evolution of the phase structure in temperature and chemical potential with variations of the strength of the interaction in the quark-quark channel and demonstrate that the phase diagram can realize a total of six different topologies. A vector interaction representing single-gluon exchange reproduces a topology commonly encountered in previous QCD models, in which a low-density chiral broken phase is separated from a high-density diquark phase by a first-order line. The other five topologies either do not possess a diquark phase or display a new phase and new critical points. Since these five cases require large variations of the coupling constants away from the values expected for a vector interaction, we conclude that the phase diagram of finite density QCD has the topology suggested by single-gluon exchange and that this topology is robust. [less ▲]

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See detailLes orfèvres mosans devant l'histoire (XIe-XIIIe siècle)
George, Philippe ULg; Stiennon, Jacques ULg; Kupper, Jean-Louis ULg

in Bulletin de la Société Royale Le Vieux-Liège (2000)

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See detailThe occurrence of 2-hydroxy-6-methoxybenzoic acid methyl ester in Securidaca longepedunculata Fresen root bark.
Lognay, Georges ULg; Marlier, M.; Seck, D. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(2),

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See detailFollicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells.
Tsunoda, R.; Heinen, Ernst ULg; Sugai, N.

in Cell & Tissue Research (2000), 299(3), 395-402

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular ... [more ▼]

Germinal center (GC) B cells are highly susceptible to apoptosis. The cellular mechanism regulating this sensitivity, however, has not yet been fully delineated. To investigate whether follicular dendritic cells (FDC) are capable of regulating the susceptibility to apoptosis of GC B cells, we constructed a GC model in vitro: emperipolesis of tonsillar B cells by FDC. We then analyzed the expressions of apoptosis-related proteins (Bcl-2 and Fas) on the cells by three-color flow cytometry. B cells nonentrapped by FDC decreased rapidly in number owing to early apoptosis in vitro, whereas entrapped B cells were rescued for at least 18 h and showed peculiar regulation of Fas and Bcl-2. GC founder cells (CD38+, IgD+; GCFC) and GC B cells (CD38+, IgD-) showed approximately a twofold increased expression of Fas; in contrast, mantle zone B cells (CD38-, IgD+) and memory B cells (CD38-, IgD-) showed no changes. Bcl-2 expression in mantle zone and memory B cells was reduced by approximately one-half; however, GCFC and GC B cells continued to express little Bcl-2 and this did not change. Our findings strongly suggest that FDC play a part in the modulation of the susceptibility to apoptosis on B cells within GC. [less ▲]

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See detailCroissance et rentabilité des plantations de douglas en Région wallonne.
Lejeune, Philippe ULg; Hebert, Jacques ULg; Rondeux, Jacques ULg

in Silva Belgica (2000), 107(1), 6-15

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité ... [more ▼]

Considéré par beaucoup de sylviculteurs européens comme une essence d'avenir, le douglas (Pseudotsuga menziesii (Mirb.) FRANCO) se caractérise avant tout par un très grand potentiel de productivité assorti de propriétés mécaniques remarquables ( de CHAMPS et DEMACQ, 1996). Encore faut-il que le sylviculteur identifie clairement l'itinéraire sylvicole à assigner à ces peuplements sur des bases aussi objectives que possibles. Les critères devant orienter ce choix relèvent autant de l'adéquation essence-station qui est un préalable à leur installation, que des exigences du marché ou encore, dans le contexte d'une sylviculture de production, de la rentabilité financière du projet sylvicole retenu. L'objectif de la présente étude est d'évaluer de manière générale la rentabilité financière potentielle d'une plantation de douglas en Wallonie. Au travers d'une comparaison de quelques scénarios sylvicoles représentatifs des grandes tendances en matière de culture de cette essence, nous essaierons également d'apprécier l'impact du choix sylvicole, non seulement sur la rentabilité du projet, mais également sur les caractéristiques dendrométriques, voire technologiques, des peuplements ainsi façonnés. Une telle démarche de comparaison de scénarios sylvicoles implique avant tout de disposer d'un outil capable de prédire, d'une manière aussi fiable que possible, l'évolution sur plusieurs décennies de peuplements forestiers soumis à un traitement sylvicole donné. Il convient également de bien préciser la démarche retenue pour effectuer les comparaisons de rentabilité financière en insistant sur l'interprétation à donner à celles-ci. Nous présenterons tout d'abord le modèle de croissance que nous avons utilisé dans le cadre de cette étude (paragraphe 2) et préciserons les modalités d'évaluation financière mises en oeuvre (paragraphe 3). Nous détaillerons ensuite, sur base des principaux paramètres sylvicoles (révolution, densité de plantation, calendrier et nature des éclaircies), les différents scénarios considérés dans cette comparaison (paragraphe 4), ainsi que leurs performances respectives (paragraphe 5). Nous conclurons enfin sur la portée des résultats enregistrés et les limitations d'une telle étude (paragraphe 6). [less ▲]

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See detailLa quittance BGU VII 1589
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (2000), LXXV(149), 111-117

BGU VII, 1589 (Philadelphia, 166/7 A.D.) in an intermediate receipt (antisymbolon). The nomographos is no tax collector.

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See detailLe point des connaissances sur les entérites à Escherichia coli chez le veau
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailEfficiency measurement, multiple-output technologies and distance functions: with application to European Railways
Coelli, Tim; Perelman, Sergio ULg

in Applied Economics (2000), (32), 1967-1976

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in ... [more ▼]

The single-output production function has long been regarded as one of the principle limitations of the econometric approach to technical efficiency measurement. If one wished to investigate efficiency in a multiple-output industry using econometric methods one would usually either: (a) aggregate outputs into a single index of output (e.g., total revenue or a multilateral Tornqvist output index); or (b) attempt to model the technology using a dual cost function. The first of these methods require that output prices be observable (and reflect revenue maximising behaviour), while the latter approach requires an assumption of cost-minimising behaviour. There are a number of instances, however, when neither of these requirements are met (the public sector contains many examples). In this study we outline the recently developed distance function solution to the multi-output problem. The method is illustrated using data on European railways. Output-orientated, input-orientated and constant returns to scale distance functions are estimated using corrected ordinary least squares. The distance function estimates are also compared with production function estimates involving aggregate output measures. These comparisons indicate that, for the case of European railways, a production function involving a multilateral Tornqvist output index exhibits substantially less aggregation bias relative to a production function that uses total revenue as a measure of aggregate output. [less ▲]

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See detailMechanical properties of Al/Al2O3 nanolaminated films: correlation to microstructure
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Surface & Coatings Technology (2000), 125(1-3), 196-200

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate ... [more ▼]

Wear resistance and the hardness of Al/Al2O3 nanolaminated films were investigated in this study. Monolithic films and multilayers were deposited on a silicon substrate with two different substrate temperatures: T-s= 25 degrees C and T-s= -90 degrees C. The period thickness of multilayers was lowering from 40 to 2 nm. From nanoindentation measurements, it appears that the hardness of multilayers has an intermediate value between those of metal (Al) and ceramic (Al2O3). The tribological test was conducted by the pin-on-disc method. The T-s=25 degrees C deposited multilayers, as well as single films, demonstrated poor wear resistance. The best wear resistance was obtained for multilayers deposited at the lowest substrate temperature (T-s= -90 degrees C). The results are ill good agreement with structural characterization. X-ray reflectometry demonstrated that the multilayer character of Al/Al2O3 is more pronounced for T-s= -90 degrees C. (C) 2000 Elsevier Science S.A. All rights reserved. [less ▲]

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See detailLes relations ethniques aux USA au début du XXIème siècle
Martiniello, Marco ULg

in Actualité du Droit (2000), 3

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See detailLe courant excito-moteur: aspects scientifiques et rééducatifs
Vanderthommen, Marc ULg

in Kine Acta (2000), 356

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See detailLes rhyncholites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Association des Géologues Amateurs de Belgique Minibul (2000), 33

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See detailExperimental and theoretical radiative lifetimes, branching fractions, and oscillator strengths for Lu I and experimental lifetimes for Lu II and Lu III
Fedchak, J. A.; Den Hartog, E. A.; Lawler, J. E. et al

in Astrophysical Journal (2000), 542

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See detailJudiciarisation et politique
Fournier, Bernard ULg; Woehrling, José

in Politique et sociétés (2000), 19(2-3), 320

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See detailLa Forêt fossile d'Overlaar, Belgique (transition Paléocène-Eocène).
Gerrienne, Philippe ULg; Damblon, Freddy ULg; Fairon-Demaret, Muriel ULg et al

in Monografias Academia Ciencias, Exactas Fisicas, Quimicas y Naturales de Zaragoza (2000), 16

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See detailLes Scarabées.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (2000), 57

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See detailEndometrial laser intrauterine thermotherapy: the first series of 100 patients observed for 1 year
Donnez, Jacques; Polet, Roland; Rabinovitz, Rafi et al

in Fertility and Sterility (2000), 74(4), 791-6

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in ... [more ▼]

Objective: To describe a new instrument (GyneLase®) that offers a new approach (endometrial laser intrauterine thermal therapy [ELITT]) to treatment of menorrhagia and to evaluate the efficacy of ELITT in the management of dysfunctional uterine bleeding. Design: Prospective study. Setting: University hospital. Patient(s): 100 premenopausal women with dysfunctional uterine bleeding were observed for 1 year. Intervention(s): Intrauterine laser thermotherapy with a diode laser. Main Outcome Measurement(s): Amenorrhea rate after 1 year. Result(s): The amenorrhea rate after 1 year of follow-up was 71%, and the rate of amenorrhea/severe hypomenorrhea rate was >90%; these rates are much higher than those in the literature after such procedures as electrosurgery or intrauterine thermal balloon therapy. The ELITT procedure is an inherently safe and simple alternative, providing controlled and effective treatment of the entire endometrium. In contrast to traditional endometrial ablation using a neodymium yttrium-aluminum-garnet laser, the ELITT procedure does not require intensive training or hysteroscopic control; it is also far less risky, because the power used per unit area is 1,000 times lower. Conclusion(s): The ELITT procedure is a new nonhysteroscopic technique for endometrial ablation. The technique is very safe and offers the highest amenorrhea rate to date in the literature. [less ▲]

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See detailDes astres à l'atome, de l'atome aux astres
Biémont, Emile ULg

in Lettre du FNRS (2000), 41

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See detailChants populaires flamands (1879) als wetenschappelijke getuigenis van een vroeg individueel repertoire: een voorstudie
Peere, Isabelle ULg

in Volkskunde (2000), (4),

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known ... [more ▼]

This article is the summary of a lecture given on the 29th conference of the Kommission für Volksdichtung in Aberdeen in August 1999. The author tests the existing context literature on the well-known folk song collection 'Chants Populaires Flamands avec les airs notés et poésies populaires diverses recueillis à Bruges' by Ad.-R. Lootens and J.M.E. Feys with novel data and on the basis of these, she sets up some new hypotheses. The writer proves that Lootens and Feys might have been relatives and that Catherine Beyaert, Lootens 's mother was, most likely, the most important source of Lootens's fielswork. Moreover, she casts a new light on the collaboration between Lootens and Feys during the realization of the manuscript. [less ▲]

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See detailIonic adsorption of ammonium and nitrate on some animal litters and their role in ammonia volatilization
Nimenya, H.; Delaunois, A.; Bloden, Serge ULg et al

in Annals of Zootechnology (2000), 49

Two experiments were carried out to determine the adsorption of ammonium and nitrate on litters (Exp. 1) and the volatilization of ammonia in their presence (Exp. 2). In Exp. 1, glass tubes containing 15 ... [more ▼]

Two experiments were carried out to determine the adsorption of ammonium and nitrate on litters (Exp. 1) and the volatilization of ammonia in their presence (Exp. 2). In Exp. 1, glass tubes containing 15 mi of a buffered solution enriched with NH4Clcalculated as 10.59 mg.l(-1) of NH4+ or KNO3 calculated as 50 mg.l(-1) of NO3- were used. Graded amounts (0 [control], 25, 50, 100 mg) of litters (wheat straw, nax straw (Equi-lin(R)), zeolite (Zeolite Stall Fresh(R)), spruce sawdust and beech sawdust) were added to the tubes which were incubated for 24 h. Ammonium and nitrate concentrations, and pH, were checked on the supernatant. A preliminary experiment was carried out with zeolite to come to an ammonium balance. After adsorption of ammoniumby graded amounts of zeolite, [0 (control), 0.25, 1, 2, 4 g], ammonium balance was assessed after two elutions with 1 N HCl. In Exp. 2, Woulff flasks were used and ammonia was trapped in a solution of 0.1 N HCl. The preliminary experiment showed that the ammonium added and adsorbed by different amounts of zeolite was completely recovered after 2 elutions. All litters, except beech sawdust, were effective in ammonium adsorption. Especially, the straws were required in very small amounts to immobilize the added ammonium or nitrate. Furthermore, with straws the pH value decreased from pH 7.5-7.60 to pH 6.90, and this effect was related to the amounts of material added. For each pH group, ammonia volatilization was significantly decreased (P <0.05) with straw (wheat straw, Equi-lino) as compared with their blank pH group. However, no significant decrease was observed with sawdust (spruce, beech) and zeolite [less ▲]

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See detailHeadache tutorial.
Russell, M. B.; Nielsen, K. D.; Rasmussen, C. et al

in Studies in Health Technology & Informatics (2000), 78

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and ... [more ▼]

The headache multimedia educational tool for the general practitioners, consists of five different modules, i.e. classification, clinical data, headache tutorial, diagnostic headache diary and nomenclature. It is possible to move between the modules both vertically and horizontally. This paper concerns the headache tutorial. It consist of case records that the user can test his diagnostic abilities on. Each case record is subdivided into an interview by the physician, physical and neurological examination, laboratory test, sum of positive diagnostic elements, suggestions of diagnoses and management. A total of 12 case records are provided. The system will be available on a CD-ROM. [less ▲]

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See detailNew f values in neutral lead obtained by time-resolved laser spectroscopy, and astrophysical applications
Biémont, Emile ULg; Garnir, Henri-Pierre ULg; Palmeri, P. et al

in Monthly Notices of the Royal Astronomical Society (2000), 312

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See detailAb initio study of organic mixed valency
Dehareng, Dominique ULg; Dive, Georges ULg; Moradpour, Alec

in International Journal of Quantum Chemistry (2000), 76(4), 552-573

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by ... [more ▼]

A series of six radical cations of the type (D-L-B)(+) was investigated at the ab initio unrestricted Hartree-Fock level. One localized and one delocalized conformation were systematically searched by full geometry optimization At both nuclear arrangements, mostly found as being minima in the symmetry-restrained Hartree-Fock framework, excitation energies were calculated through the expansion of the wave function on single electronic excitations of the Hart ee-Fock fundamental determinant and at the unrestricted Hartree-Fock or at the multiconfigurational self consistent field levels. Few calculations were also performed by taking into account some part of the electronic correlation. Except for N,N,N',N'-tetramethyl p-phenylenediamine, all the studied compounds are localized stable cations, at the symmetry-restrained Hartree-Fock level. However, the reoptimization of their wave function changes this observation since only three of them seem to conserve a localized stable conformation. Most of the studied systems are characterized by one or two excited electronic states very dose to the fundamental one and should thus present an unresolved broadened first absorption band in the near-infrared region These features are in agreement with the available experimental data. Strong Hartree-Fock instabilities are found for the delocalized structure and put in relation with the existence of the large nonadiabatic coupling in this conformational region. The solvent influence is discussed in the Onsager dipolar reaction field framework. (C) 2000 John Wiley & Sons, Inc. [less ▲]

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See detailLa variation de l’équilibre glycémique (mais pas du poids) est corrélée positivement à la modification du risque cardiovasculaire absolu chez le patient diabétique
Hadjadj, Samy; Guilloteau, Gérard; Weekers, Laurent ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (2000), 93(8), 1033-1036

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See detailStructural and electronic properties of high-temperature fluid selenium
Raty, Jean-Yves ULg; Saul, A.; Gaspard, Jean-Pierre ULg et al

in Computational Materials Science (2000), 17(2-4), 239-242242

A semi-empirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces. The band structure parameters are ... [more ▼]

A semi-empirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces. The band structure parameters are obtained by fitting ab initio calculations. The simulated liquid structures are in very good agreement with the most recent X-ray scattering and EXAFS measurements. The Monte Carlo simulations performed show that the complex liquid structures observed result from the breaking and branching of the selenium chains. The total coordination number is shown to result from the balance between one-, two- and three-fold coordinated atoms. The role of these defects is discussed in relationship with the electrical conductivity of the liquid, i.e. the semiconductor-metal and metal-non-metal transitions observed at high pressure and temperature [less ▲]

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See detailResults of the tracer tests during the El Tremedal underground coal gasification at great depth
Pirard, Jean-Paul ULg; Brasseur, Alain; Coeme, Antoinette et al

in Fuel (2000), 79(5), 471-478

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases ... [more ▼]

During the underground coal gasification (UCG) experiments at Alcorisa, Spain, a series of helium tracer tests were carried out to follow the underground cavity growth. The volume of the cavity increases progressively with the cumulated quantity of oxygen injected. Models based on exchange of matter between the flowing fluid and a transverse dead zone were used. Results indicate that the gasifier behaves almost like a small number of stirred tanks in series with a high level of back mixing. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailConsidérations sur l'action en opposabilité d'un jugement étranger
Boularbah, Hakim ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2000)

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See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

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See detailHyperthermic induction of the 27-kDa heat shock protein (Hsp27) in neuroglia and neurons of the rat central nervous system.
Krueger-Naug, A. M.; Hopkins, D. A.; Armstrong, J. N. et al

in Journal of Comparative Neurology (The) (2000), 428(3), 495-510

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in many neurons of the brainstem and spinal cord, is strongly induced in glial cells in response to ischemia, seizures, or spreading ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in many neurons of the brainstem and spinal cord, is strongly induced in glial cells in response to ischemia, seizures, or spreading depression, and is selectively induced in neurons after axotomy. Here, the expression of Hsp27 was examined in brains of adult rats from 1.5 hours to 6 days after brief hyperthermic stress (core body temperature of 42 degrees C for 15 minutes). Twenty-four hours following hyperthermia, Western blot analysis showed that Hsp27 was elevated in the cerebral cortex, hippocampus, cerebellum, and brainstem. Immunohistochemistry for Hsp27 revealed a time-dependent, but transient, increase in the level of Hsp27 immunoreactivity (Hsp27 IR) in neuroglia and neurons. Hsp27 IR was detected in astrocytes throughout the brain and in Bergmann glia of the cerebellum from 3 hours to 6 days following heat shock. Peak levels were apparent at 24 hours, gradually declining thereafter. In addition, increases in Hsp27 IR were detected in the ependyma and choroid plexus. Hyperthermia induced Hsp27 IR in neurons of the subfornical organ and the area postrema within 3 hours and reached a maximum by 24 hours with a return to control levels 4-6 days after hyperthermia. Specific populations of hypothalamic neurons also showed Hsp27 IR after hyperthermia. These results demonstrate that hyperthermia induces transient expression of Hsp27 in several types of neuroglia and specific populations of neurons. The pattern of induced Hsp27 IR suggests that some of the activated cells are involved in physiological responses related to body fluid homeostasis and temperature regulation. [less ▲]

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See detailVibrational Structure and Organization of Various Self-Assembled Alkanethiol Monolayers: a HREELS Study
Duwez, Anne-Sophie ULg; Yu, Li-Ming; Riga, Joseph et al

in Langmuir (2000), 16

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R ... [more ▼]

High-resolution electron energy loss spectroscopy (HREELS) was used to investigate the molecular structure of self-assembled monolayers formed by adsorption of n-alkanethiols, R,ö-alkanedithiols, and R-cycloalkyl-ö-alkanethiols on different gold substrates. The HREELS data are reported as a contribution to a general effort to assess the potential of electron spectroscopies in the elucidation of structural characteristics of organic surfaces. Typical fingerprints of the thiol molecules, characteristic of their primary and secondary structure (connectivity, conformation, and order), have been found in their HREELS vibrational spectra. We have shown that when the layers are disordered, the spectra are dominated by impact-excited modes, hampering the identification of the compounds. These data have evidenced many defects in the organization of the monolayers on evaporated gold substrates. The coherent domains sizes formed by the molecules in the films have been estimated from the angular distribution of the elastic peak as a function of the nature of the alkanethiol chain and of the immersion time in thiol solutions [less ▲]

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See detailLe Peuplier
Jourez, Benoît ULg; Quin, Jean-Philippe; Mertens, Patrick

in Courrier du Bois (2000), 40(131), 11-16

Essence de production par excellence, le peuplier revêt une importance économique non négligeable. L'extension de sa culture basée sur les nouveaux cultivars, la qualité de son bois et son aptitude à la ... [more ▼]

Essence de production par excellence, le peuplier revêt une importance économique non négligeable. L'extension de sa culture basée sur les nouveaux cultivars, la qualité de son bois et son aptitude à la transformation, en ont fait une essence qui a pris de l'importance dans certaines branches de l'industrie du bois. [less ▲]

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See detailDNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase.
Verdemato, P. E.; Brannigan, J. A.; Damblon, Christian ULg et al

in Nucleic Acids Research (2000), 28(19), 3710-8

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and ... [more ▼]

The C-terminal domain of the Escherichia coli Ada protein (Ada-C) aids in the maintenance of genomic integrity by efficiently repairing pre-mutagenic O:(6)-alkylguanine lesions in DNA. Structural and thermodynamic studies were carried out to obtain a model of the DNA-binding process. Nuclear magnetic resonance (NMR) studies map the DNA-binding site to helix 5, and a loop region (residues 151-160) which form the recognition helix and the 'wing' of a helix-turn-wing motif, respectively. The NMR data also suggest the absence of a large conformational change in the protein upon binding to DNA. Hence, an O:(6)-methylguanine (O:(6)meG) lesion would be inaccessible to active site nucleophile Cys146 if the modified base remained stacked within the DNA duplex. The experimentally determined DNA-binding face of Ada-C was used in combination with homology modelling, based on the catabolite activator protein, and the accepted base-flipping mechanism, to construct a model of how Ada-C binds to DNA in a productive manner. To complement the structural studies, thermodynamic data were obtained which demonstrate that binding to unmethylated DNA was entropically driven, whilst the demethylation reaction provoked an exothermic heat change. Methylation of Cys146 leads to a loss of structural integrity of the DNA-binding subdomain. [less ▲]

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See detailAssessment of Complex Perineal Fistulas
Bruyninx, Luc ULg; Meunier, Paul ULg

in Acta Chirurgica Belgica (2000), 100(3, May-Jun), 115-7

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See detailStructure-activity relationships on adrenoceptors and imidazoline-preferring binding sites (I(1,2)-PBSs). Part 1: Weak intramolecular H-bond and conformational flexibility in a new I1-PBS-selective imidazoline analogue, trans1-(4',5'-dihydro-1'H-imidazol-2'-yl)methyl-2-hydroxyindane (PMS 952).
Ye, Hai Fen; Dive, Georges ULg; Dehareng, Dominique ULg et al

in Bioorganic & Medicinal Chemistry (2000), 8(8), 1861-9

The highly selective I1-PBS imidazoline analogue PMS 952 has been selected to study the incidence of intramolecular hydrogen bond and molecular flexibility on its biological activity. On one hand, the ... [more ▼]

The highly selective I1-PBS imidazoline analogue PMS 952 has been selected to study the incidence of intramolecular hydrogen bond and molecular flexibility on its biological activity. On one hand, the weak energy difference between three calculated conformers does not support the stabilization of one conformer by an internal hydrogen bond. The 3-D electrostatic map confirms this feature and the solvent effect does not significantly modify the relative energy of these conformers. On the other hand, the conformational spaces of the neutral and ionized forms present a great number of equilibrium structures, in a short energetic range (20 Kcal). The results are representative of an exceptional conformational flexibility due to a cooperative effect between several parts of the molecule. [less ▲]

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See detailMatrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis
Ribbens, Clio ULg; Andre, Béatrice ULg; Jaspar, J. M. et al

in Journal of Rheumatology (2000), 120(1), 888-893

OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). METHODS: Serum MMP-3 ... [more ▼]

OBJECTIVE: To demonstrate that serum matrix metalloproteinase-3 (MMP-3) is a variable associated with disease activity and with the response to treatment in rheumatoid arthritis (RA). METHODS: Serum MMP-3 levels were measured and compared to biological and clinical disease activity variables in 20 patients with active RA assessed serially during a one year prospective open label trial with methotrexate or tenidap. RESULTS: MMP-3 levels were significantly correlated with C-reactive protein (CRP) and interleukin 6 serum levels as well as with the disease activity score (DAS), not only at start in untreated patients but also during the 12 month followup period in both treated groups. Early changes (after 0.5, 1, 2, or 3 months) in MMP-3 levels were significantly associated with change in DAS observed 4 to 6 months later. CONCLUSION: In addition to CRP, a systemic marker of inflammation, serum MMP-3 may serve as a consistent synovial derived marker of RA disease activity, early changes of which predict disease outcome. [less ▲]

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See detailRetrospective study of 206 cases of surgical intestinal pathologies in the horse : incidence, diagnosis, prognosis and complications.
Grulke, Sigrid ULg; Gangl, Monika; Caudron, Isabelle et al

in Annales de Médecine Vétérinaire (2000), 144

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation ... [more ▼]

This retrospective study of 206 surgical colic cases shows the incidence of the different types of pathologies. The small intestine is concerned in 106 (51,5 %) cases with 102 (96 %) strangulation obstructions. The remaining 100 cases (48,5 %) are large intestine obstructions with 45 (45 %) strangulation obstructions. The global survival rate is of 51,5 %, of 42,2 % for small intestine and of 61 % for large intestine. A gravity and a shock score permit to define the prognosis before the decision for surgery. The incidence of the postoperative complications is higher (55,2 %) and the time for recovery is significantly longer for small intestinal pathologies than for large intestine affections. Shock and paralytic ileus are the most frequent complications accounting for 65 % of post operative mortalities. The survival rates are significantly different according to gravity and shock score. The time of recovery is also significantly different in function of the shock score. These findings show the importance of rapid diagnosis of the acute abdominal disease in order to improve the outcome. [less ▲]

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See detailStructural effects of the active site mutation cysteine to serine in Bacillus cereus zinc-beta-lactamase.
Chantalat, L.; Duee, E.; Galleni, Moreno ULg et al

in Protein science : a publication of the Protein Society (2000), 9(7), 1402-6

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the ... [more ▼]

Beta-lactamases are involved in bacterial resistance. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are becoming thus of major clinical importance. Despite the availability of Zn-beta-lactamase X-ray structures their mechanism of action is still unclear. One puzzling observation is the presence of one or two zincs in the active site. To aid in assessing the role of zinc content in beta-lactam hydrolysis, the replacement by Ser of the zinc-liganding residue Cys168 in the Zn-beta-lactamase from Bacillus cereus strain 569/H/9 was carried out: the mutant enzyme (C168S) is inactive in the mono-Zn form, but active in the di-Zn form. The structure of the mono-Zn form of the C168S mutant has been determined at 1.85 A resolution. Ser168 occupies the same position as Cys168 in the wild-type enzyme. The protein residues mostly affected by the mutation are Asp90-Arg91 and His210. A critical factor for the activity of the mono-Zn species is the distance between Asp90 and the Zn ion, which is controlled by Arg91: a slight movement of Asp90 impairs catalysis. The evolution of a large superfamily including Zn-beta-lactamases suggests that they may not all share the same mechanism. [less ▲]

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See detailRisedronate reverses bone loss in postmenopausal women with low bone mass: results from a multinational, double-blind, placebo-controlled trial. BMD-MN Study Group.
Fogelman, I; Ribot, C; Smith, R et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(5), 1895-900

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months ... [more ▼]

Our objective was to investigate the efficacy and tolerability of risedronate in postmenopausal women with low bone mass. Women with a mean lumbar spine T-score of -2 or less (n = 543) received 24 months of placebo or risedronate (2.5 or 5 mg/day). All received calcium (1 g/day). The principal outcome measures were bone mineral density (BMD) at the lumbar spine, femoral neck, and femoral trochanter. At 24 months, lumbar spine BMD increased from baseline by 4% with 5 mg risedronate and 1.4% in the 2.5-mg group, compared with no change with placebo. Efficacy was similar in women who were less than 5 yr and more than 5 yr postmenopausal. At 24 months, risedronate (5 mg) had also increased BMD at the femoral neck and trochanter, whereas BMD decreased in the placebo group. BMD increases were seen at all three sites with risedronate (5 mg) after only 6 months of therapy. Risedronate was well tolerated; upper gastrointestinal adverse events were similar to placebo. We conclude that risedronate (5 mg) increases BMD rapidly and effectively and is well tolerated in postmenopausal women with low bone mass, regardless of time since menopause. [less ▲]

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See detailGestire la diversità culturale e identitaria
Martiniello, Marco ULg

in Il Mulino (2000), anno XLIX(391), 881-889

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See detailcompte rendu de : La 'parola' delle immagini e delle forme di scrittura. Modi e tecniche della comunicazione nel mondo antico
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2000), 78(1), 200-203

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See detailSilencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6
Busch, Kerstin; Martin, Bernd; Baniahmad, Aria et al

in Molecular Endocrinology (Baltimore, Md.) (2000), 14(2), 201-11

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression ... [more ▼]

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression by TR in the absence of ligand is mediated by an active silencing mechanism. The oncogene v-ErbA is a variant form of TR unable to bind hormone and thus acts as a constitutive repressor. Functional studies and mutation analysis revealed that the TR/v-ErbA silencing domain is composed of three silencing subdomains (SSD1-3) which, although nonfunctional individually, synergize such that silencing activity is restored when they are combined in a heteromeric complex. Here we demonstrate, using protein interaction assays in vitro and in vivo, that the inactive v-ErbA point mutant L489R within helix 5/6 in SSD2 fails to interact with the two corepressors N-CoR (nuclear receptor corepressor) or SMRT (silencing mediator of retinoic acid and thyroid hormone receptor). Furthermore, mutants in SSD1 and SSD3 exhibit a reduced corepressor recruitment corresponding to their weak residual silencing activity. In mammalian two-hybrid assays, only the combination of all three silencing subdomains, SSD1-3, leads to a cooperative binding to the corepressors N-CoR or SMRT comparable to that of the full-length v-ErbA repression domain. In conclusion, full silencing activity requires corepressor interaction with all three silencing subdomains, SSD1-3. Among these, SSD2 is a new target for N-CoR and SMRT and is essential for corepressor binding and function. [less ▲]

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See detailHacia una psicologia integradora : utopia o necesidad ?
Richelle, Marc ULg

in Revista de Psicologia General y Aplicada (2000), 53(4), 581--588

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See detailLa pleuropneumonie contagieuse bovine
Linden, Annick ULg; Desmecht, Daniel ULg

in Vlaams Diergeneeskundig Tijdschrift (2000), 69

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See detailCharacterization of two Acacia gums and their fractions using a Langmuir film balance
Fauconnier, Marie-Laure ULg; Blecker, Christophe ULg; Groyne, J. et al

in Journal of Agricultural and Food Chemistry (2000), 48(7), 2709-2712

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied ... [more ▼]

The mechanical properties of monolayers from two Acacia gums [Acacia senegal (L.) Willd. and Acacia seyal Del.] and their three fractions isolated by hydrophobic interaction chromatography were studied with a Langmuir film balance to obtain a more complete understanding of their action mode. The analysis of compression isotherms revealed that A. senegal gums globally exhibit better interfacial properties than A. seyal ones. The behavior of the whole gums appeared to be strongly influenced by their arabinogalactan-protein complex. [less ▲]

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See detailClinical and neuropathological parameters affecting the diagnostic yield of nerve biopsy.
Deprez, Manuel ULg; de Groote, C. C.; Gollogly, L. et al

in Neuromuscular Disorders (2000), 10(2), 92-8

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for ... [more ▼]

The value of nerve biopsy in the investigation of peripheral neuropathies is an important and controversial issue, partially obscured by the large variations in the diagnostic yield routinely reported for this procedure. The aim of this study was to evaluate the clinical and neuropathological parameters affecting the yield of nerve biopsy. We compared the experience of two independent neuropathology laboratories with different patient recruitment and neuropathological methods over 11 years (01/1987-12/1997). Clinicopathological correlations were studied retrospectively in 355 patients. Using the same criteria of evaluation, contributive biopsies accounted for 35.5% in one laboratory, and 47.3% in the other. Clinical parameters affecting the yield of nerve biopsy were: (a) the presumptive diagnosis at time of referral for biopsy; (b) the distribution of symptoms; and (c) the interval between disease onset and biopsy. Greater yield was associated with clinically suspected vasculitis, inflammatory demyelinating neuropathy or hereditary sensorimotor neuropathies. Contributive findings were more often reported with multifocal or asymmetrical presentations, and onset-to-biopsy interval of less than 6 months. The contribution of nerve biopsy varied according to neuropathological techniques: (a) serial sections on frozen. paraffin-embedded and resin-embedded material improved sensitivity for interstitial pathology: (b) combined muscle biopsy increased sensitivity in the detection of vasculitis; and (c) teasing of nerve fibers added critical information to other classical techniques in only 4/102 cases. [less ▲]

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See detailHamstring muscle tear with recurrent complaints: An isokinetic profile
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Isokinetics & Exercise Science (2000), 8(3), 175-180

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See detailThe Optimisation Of The Helix/Helix Interaction Of A Transmembrane Dimer Is Improved By The Impala Restraint Field
Ducarme, P.; Thomas, Annick ULg; Brasseur, Robert ULg

in Biochimica et Biophysica Acta-Biomembranes (2000), 1509(1-2), 148-54

A continuous membrane model (IMPALA) was previously developed to predict how hydrophobic spans of proteins insert in membranes (Mol. Mod. 2 (1996) 27). Using that membrane model, we looked for the ... [more ▼]

A continuous membrane model (IMPALA) was previously developed to predict how hydrophobic spans of proteins insert in membranes (Mol. Mod. 2 (1996) 27). Using that membrane model, we looked for the interactions between several hydrophobic spans. We used the glycophorin A dimer as an archetype of polytopic protein to validate the approach. We find that the native complex do not dislocate when it is submitted to a 10(5) steps optimisation whereas separated spans converge back to a native-like complex in the same conditions. We also observe that IMPALA restraints are not strictly mandatory but do increase the efficiency of the procedure. [less ▲]

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See detailThe unseen face of humanitarian crisis in eastern Democratic Republic of Congo: was nutritional relief properly targeted?
Porignon, Denis ULg; Katulanya, I.; Elongo, L. et al

in Journal of epidemiology and community health (2000), 54(1), 6-9

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic ... [more ▼]

STUDY OBJECTIVE: Comparison of children's nutritional status in refugee populations with that of local host populations, one year after outbreak refugee crisis in the North Kivu region of Democratic Republic of Congo. DESIGN: Cross sectional surveys. SETTING: Temporary and other settlements, in the town of Goma and surrounding rural areas. SUBJECTS: Anthropometric indicators of nutritional status and presence or absence of oedema were measured among 5121 children aged 6 to 59 months recruited by cluster sampling with probability proportional to size, between June and August 1995. RESULTS: Children in all locations demonstrated a typical pattern of growth deficit relative to international reference. Prevalence of acute malnutrition (wt/ht < -2 Z score) was higher among children in the rural non-refugee populations (3.8 and 5.8%) than among those in the urban non-refugee populations (1.4%) or in the refugee population living in temporary settlements (1.7%). Presence of oedema was scarcely noticed in camps (0.4%) while it was a common observation at least in the most remote rural areas (10.1%). As compared with baseline data collected in 1989, there is evidence that nutritional status was worsening in rural non-refugee populations. CONCLUSIONS: Children living in the main town or in the refugee camps benefited the most from nutritional relief while those in the rural non-refugee areas were ignored. This is a worrying case of inequity in nutritional relief. [less ▲]

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See detailFirst insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz, Marianne ULg; Van de Ven, W. J.; Kas, K.

in Advances in Dental Research (2000), 14

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10 ... [more ▼]

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is various translocations involving 12q15. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8q12. The most frequently encountered aberration in this group is a t(3;8)(p21;q12). [less ▲]

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See detailInduction of phenolic compounds in two cultivars of cucumber by treatment of healthy and powdery mildew-infected plants with extracts of Reynoutria sachalinensis
Daayf, Fouad; Ongena, MARC ULg; Boulanger, Renald et al

in Journal of Chemical Ecology (2000), 26

Accumulation of phenolic compounds (p-coumaric, caffeic, and ferulic acids and p-coumaric acid methyl ester) was followed in susceptible (Mustang) and tolerant (Flamingo) cucumber (Cucumis sativus ... [more ▼]

Accumulation of phenolic compounds (p-coumaric, caffeic, and ferulic acids and p-coumaric acid methyl ester) was followed in susceptible (Mustang) and tolerant (Flamingo) cucumber (Cucumis sativus) cultivars. The objective was to determine whether these compounds played a role in resistance against powdery mildew following a prophylactic treatment with Milsana (leaf extracts from the giant knot weed Reynoutria sachalinensis, polygonaceae). This treatment significantly reduced the incidence of powdery mildew in both cultivars. Phenolic compounds were extracted from leaves. In the hydrolyzed fraction containing phenolic aglycones, levels of p-coumaric, caffeic, and ferulic acids and of p-coumaric acid methyl ester increased in all treatments (with leaf extracts of R. Sachalinensis, powdery mildew, or both) except the control, one or two days after treatment. In the fraction containing free phenolics, from the tested compounds, only ferulic acid showed an increase in cv. Flamingo (tolerant), and was particularly evident following treatments. On the other hand, the amounts of hydroxycinnamic acids increased rapidly in the two cultivars following Milsana treatment, suggesting their role in disease reduction. All compounds showed antifungal activity when tetsed against common pathogens of cucumber (Botrytis cinerea, Pythium ultimum, and P. aphanidermatum), but in general methyl esters were more fungitoxic than their corresponding free acids. This study suggests that cucumber is able to release antifungal compounds that are instrumental in repressing powdery mildew infection. This response is seemingly independent from the level of genetic resistance associated with each cultivar. [less ▲]

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See detailA further locality with foliicolous lichens in Italy, with taxonomical and ecological data on foliicolous lichens in Western Europe
Puntillo, Domenico; Bricaud, Olivier; Sérusiaux, Emmanuël ULg

in Cryptogamie. Mycologie (2000), 21

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See detailNutrient depletions in the Ross Sea and their relation with pigment stocks
Goeyens, Leo; Elskens, Marc; Catalano, Giulio et al

in Journal of Marine Systems (2000), 27

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises ... [more ▼]

The present article depicts a first attempt to relate the governing nutrient uptake regime and phytopigment signature of the Ross Sea. Based on nutrient and phytopigment data obtained during two cruises in the Ross Sea, two distinct groups were recognised. The first one was characterised by moderate nutrient nitrate and silicic acid depletions in combination with relatively high diatom and Phaeocystis abundance. The second group showed very low nutrient depletions and very poor diatom abundance. Average depth specific nitrate depletions were 8.1 and 1.1 μM and average silicic acid depletions were 21.5 and 1.3 μM, respectively. The nutrient consumption patterns did not match the conditions of silicic acid excess (SEA) or nitrate excess areas (NEA), a clear trend being probably obscured by very poor seasonal maturity of several sampling stations. The contrast between both groups is largely explained by small differences in nitrogen uptake regime of the major phytoplankters. During early season, the diatoms meet the majority of their nitrogen requirements by nitrate uptake, with few exceptions where ammonium is the most important nitrogenous substrate. On average, their nitrate uptake capacity is lower than that of Phaeocystis (average specific nitrate uptake rates were 0.021 and 0.036 day y-1 for diatoms and Phaeocystis, respectively). The latter phytoplankton always shows predominance of nitrate uptake. Both groups are subject to inhibition of nitrate uptake when ammonium availability increases, and it is likely that the diatoms are more sensitive to the inhibitory effect of ammonium. [less ▲]

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See detailIdentification Of Key Residues For Interaction Of Vasoactive Intestinal Peptide With Human Vpac(1) And Vpac(2) Receptors And Development Of A Highly Selective Vpac(1) Receptor Agonist - Alanine Scanning And Molecular Modeling Of The Peptide
Nicole, P.; Lins, Laurence ULg; Rouyer-Fessard, C. et al

in Journal of Biological Chemistry (2000), 275(31), 24003-12

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan ... [more ▼]

The widespread neuropeptide vasoactive intestinal peptide (VIP) has two receptors VPAC(1) and VPAC(2). Solid-phase syntheses of VIP analogs in which each amino acid has been changed to alanine (Ala scan) or glycine was achieved and each analog was tested for: (i) three-dimensional structure by ab initio molecular modeling; (ii) ability to inhibit (125)I-VIP binding (K(i)) and to stimulate adenylyl cyclase activity (EC(50)) in membranes from cell clones stably expressing human recombinant VPAC(1) or VPAC(2) receptor. The data show that substituting residues at 14 positions out of 28 in VIP resulted in a >10-fold increase of K(i) or EC(50) at the VPAC(1) receptor. Modeling of the three-dimensional structure of native VIP (central alpha-helice from Val(5) to Asn(24) with random coiled N and C terminus) and analogs shows that substitutions of His(1), Val(5), Arg(14), Lys(15), Lys(21), Leu(23), and Ile(26) decreased biological activity without altering the predicted structure, supporting that those residues directly interact with VPAC(1) receptor. The interaction of the analogs with human VPAC(2) receptor is similar to that observed with VPAC(1) receptor, with three remarkable exceptions: substitution of Thr(11) and Asn(28) by alanine increased K(i) for binding to VPAC(2) receptor; substitution of Tyr(22) by alanine increased EC(50) for stimulating adenylyl cyclase activity through interaction with the VPAC(2) receptor. By combining 3 mutations at positions 11, 22, and 28, we developed the [Ala(11,22,28)]VIP analog which constitutes the first highly selective (>1,000-fold) human VPAC(1) receptor agonist derived from VIP ever described. [less ▲]

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See detailSeismic hazard in the Sea of Marmara following the Izmit Earthquake
Hubert, Aurelia ULg; Barka, Aykut; Jacques, Eric et al

in Nature (2000), 404

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average ... [more ▼]

On 17 August 1999, a destructive magnitude 7.4 earthquake occurred 100 km east of Istanbul, near the city of Izmit, on the North Anatolian fault. This 1,600-km-long plate boundary1,2 slips at an average rate of 2–3 cm yr−1 (refs 3–5), and historically has been the site of many devastating earthquakes6,7. This century alone it has ruptured over 900 km of its length6. Models of earthquake-induced stress change8 combined with active fault maps9 had been used to forecast that the epicentral area of the 1999 Izmit event was indeed a likely location for the occurrence of a large earthquake9,10. Here we show that the 1999 event itself significantly modifies the stress distribution resulting from pre- vious fault interactions9,10. Our new stress models take into account all events in the region with magnitudes greater than 6 having occurred since 1700 (ref. 7) as well as secular interseismic stress change, constrained by GPS data11. These models provide a consistent picture of the long term spatio–temporal behaviour of the North Anatolian fault and indicate that two events of magnitude equal to, or greater than, the Izmit earthquake are likely to occur within the next decades beneath the Marmara Sea, south of Istanbul. [less ▲]

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See detailTheoretical Lifetimes and Oscillator Strengths in Ce II. Application to the Chemical Composition of the Sun
Palmeri, P.; Quinet, Pascal ULg; Wyart, J. F. et al

in Physica Scripta (2000), 61

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See detailPersistent tumor 18F-FDG uptake after a few cycles of polychemotherapy is predictive of treatment failure in non-Hodgkin's lymphoma.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2000), 85(6), 613-8

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve ... [more ▼]

BACKGROUND AND OBJECTIVE: Early recognition of the ineffectiveness of chemotherapy could result in lower cumulative drug toxicity and tumor burden at the start of salvage therapy, which might improve clinical outcome. Therefore, we studied the value of (18)F-FDG PET for early evaluation of response in patients with non-Hodgkin's lymphoma (NHL). DESIGN AND METHODS: We studied 28 patients by (18)F-FDG PET after a median of 3 cycles of polychemotherapy. The presence or absence of abnormal (18)F-FDG uptake was correlated to clinical outcome (median follow-up: 17.5 months, range 4-47 months). RESULTS: Five of 28 patients still had increased (18)F-FDG uptake in one or more sites previously shown to be involved by lymphoma at baseline evaluation. Only one of these five patients entered complete remission (CR), whereas among the 23 patients with negative (18)F-FDG PET studies, two died of toxicity during chemotherapy and all the others entered clinical CR (p<0.00001). All five patients with and 7/21 patients without residual abnormal (18)F-FDG uptake relapsed or reprogressed (positive predictive value for relapse: 100%, negative predictive value: 67%). By Kaplan-Meier analysis, progression-free survival (PFS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive patients and 81+/-9% and 62+/-12% for (18)F-FDG PET negative patients (p=0.0001). Overall survival (OS) at 1 and 2 years was respectively 20+/-18% and 0% for (18)F-FDG PET positive and 87+/-7% and 68+/-11% for (18)F-FDG PET negative patients (p<0.0001). INTERPRETATION AND CONCLUSIONS: Persistent tumoral (18)F-FDG uptake after a few cycles of polychemotherapy is predictive of CR, PFS and OS in NHL. Further studies are warranted to determine whether (18)F-FDG PET has a predictive value independent from conventional prognostic factors. However, the sensitivity of qualitative (18)F-FDG PET imaging in identifying patients with a poor outcome was insufficient. Earlier evaluation after only one cycle of chemotherapy and quantitative analysis might increase the sensitivity of 18F-FDG PET is predicting treatment failure. [less ▲]

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See detailModelaçao numérica do comportamento de uma estrutura metalica sujeita à acçao do fogo - Analise de varios cenarios de incëndio
Vila Real, P. M. M.; Piloto, P. A. G.; Franssen, Jean-Marc ULg

in Revista Portuguesa de Engenharia de Estruturas (RPEE) (2000), 47

In this work it has been analysed several possible fire scenarios in a steel structure of a commercial building, in order to find which one corresponds to the lowest fire resistance of the structure. It ... [more ▼]

In this work it has been analysed several possible fire scenarios in a steel structure of a commercial building, in order to find which one corresponds to the lowest fire resistance of the structure. It has been used a geometrically and materially non-linear finite element program specially established for the analysis of structures submitted to the fire. As the analysed structure doesn't reach the fire resistance suggested by the Portuguese standards, some solutions are proposed to increase its fire resistance. [less ▲]

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See detailManagement perspectives on a deep aquifer system for rural water supply in Olt and Valcea counties - Romania
Dinu, Irina; Albu, Marius; Moldoveanu, Victor et al

in Lakes & Reservoirs : Research & Management (2000), 5

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See detail1re campagne de fouille à Chagar Bazar (Syrie)
Tunca, Önhan ULg; McMahon, A.; Baghdo, Abd el-Massih

in Orient-Express 2000/1 (2000)

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See detailTrophics relationships between planktonic micro-organisms in the river Meuse (Belgium): a carbon budget
Servais, Pierre; Gosselain, Véronique; Joaquim-Justo, Célia ULg et al

in Arch. Hydrobiol (2000)

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See detailp63 is a prostate basal cell marker and is required for prostate development.
Signoretti, Sabina; Waltregny, David ULg; Dilks, James et al

in American Journal of Pathology (2000), 157(6), 1769-75

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many ... [more ▼]

The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as skin appendages and the breast. Here, we show that prostate basal cells, but not secretory or neuroendocrine cells, express p63. In addition, prostate basal cells in culture predominantly express the DeltaNp63alpha isotype. In contrast, p63 protein is not detected in human prostate adenocarcinomas. Finally, and most importantly, p63(-/-) mice do not develop the prostate. These results indicate that p63 is required for prostate development and support the hypothesis that basal cells represent and/or include prostate stem cells. Furthermore, our results show that p63 immunohistochemistry may be a valuable tool in the differential diagnosis of benign versus malignant prostatic lesions. [less ▲]

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See detailNew or interesting records of foliicolous lichens. VII. Calenia flava (Ostropales: Gomphillaceae)
Lücking, Robert; Sérusiaux, Emmanuël ULg; Sipman, J.M. Harrie

in Tropical Bryology (2000), 19

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See detail"note sous J.P. Jumet, 19 février 1998"
Moreau, Pierre ULg

in Actualités du Droit (2000)

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See detailL'analyse de la variance multivariée et l'analyse canonique discriminante : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (2000), (1), 40

This note describes the principles of multivariate analysis of variance and of canonical discriminant analysis. The methods are illustrated by two examples.

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See detailEvaluation des concentrations plasmatiques en anti-oxydants, anticorps contre les LDL oxydees et homocysteine dans un echantillon de la population liegeoise
Pincemail, Joël ULg; Siquet, Jean ULg; Chapelle, Jean-Paul ULg et al

in Annales de Biologie Clinique (2000), 58(2, Mar-Apr), 177-85

A large number of epidemiological and clinical studies suggest that oxidative stress plays an important role in the development of cardiovascular diseases. In this way, following reference values in ... [more ▼]

A large number of epidemiological and clinical studies suggest that oxidative stress plays an important role in the development of cardiovascular diseases. In this way, following reference values in plasmatic antioxidants have been determined in a group of 123 blood donors (94 males, 29 females; age: 21-64 years) living in the surroundings of Liege, Belgium: vitamin A (1.5-3.62 mmol/l), vitamin C (3.68-75.21 mmol/l), vitamin E (16.98-46.46 mmol/l), ratio vitamin E/cholesterol (3.92-8.32 mmol/mmol), selenium (0.66-1.26 mmol/l), sulphydryl proteins (216-556 mmol/l), uric acid (174-477 mmol/l), superoxide dismutase (542-852 IU/g hemoglobine), glutathion peroxidase (39.55-91.83 IU/g hemoglobine). Only a few number of subjects were found with values corresponding to high risk of deficiency in antioxidants although low values in vitamin C (< 11.35 mmol/l) and in selenium (< 0.75 mmol/l) were respectively observed in 5.69 and 10.5% of our subjects. Autoantibodies against oxidized LDL, as marker of oxidative stress, and homocysteine, as a risk factor of atherosclerosis involved in the development of oxidative stress, have also been investigated. Approximatively 40% of the population presented values higher than the superior limit mean value (20.3% > 650 IU/l in autoantibodies and 19.5% > 15.2 mmol/l in homocysteine) that are, however, not correlated with age or low levels in antioxidants. The effect of smoking (25% of the population) contributed to significantly decrease vitamin C, selenium and glutathion peroxidase concentrations by 31.9 and 13% when compared to nonsmokers. Intake of 1 to 4 fruits per day resulted in a significant increase of 56.9% in vitamin C when compared to nonconsumers (26.8% of the population). In contrast, homocysteine concentrations were significantly decreased by 21.4% in fruits consumers. Thank to the development of methods allowing the routine dosage of all these parameters, general practitioners can now easily establish the oxidative stress status of their patients and, as fonction of getting patterns, detect populations at risk of developing cardiovascular diseases. [less ▲]

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See detailPsychiatrie en osteoporose
Halkin, V; Reginster, Jean-Yves ULg

in Agenda Psychiatrie (L') (2000), 14

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See detailEnantioseparation of aminoglutethimide with cyclodextrins in capillary electrophoresis and studies of selector-selectand interactions using NMR spectroscopy and electrospray ionization mass spectrometry.
Chankvetadze, Bezhan; Fillet, Marianne ULg; Burjanadze, N. et al

in Enantiomer (2000), 5(3-4), 313-22

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The ... [more ▼]

The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs. The migration order of the enantiomers was opposite using beta-CD compared to alpha- and gamma-CDs as chiral selectors. In order to examine some underlying mechanisms of the chiral recognition the interaction of AGT with the chiral selectors was studied with one- and two-dimensional NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). The Job's and Scott's plots constructed based on the complexation-induced chemical shifts (CICS) observed in NMR spectra provided some preliminary information on the stoichiometry of the intermolecular complexes but did not seem to be absolutely reliable perhaps because the self-association of the analyte molecules and the formation of multiple type selectand-selector complexes. Therefore, an attempt was made to characterize the complexes using ESI-MS. This technique provided information on the stoichiometry and relative affinity constants of selector-selectand complexes. The information on the structure of complexes in the solution was obtained using one-dimensional rotating frame nuclear Overhauser enhancement (1D-ROESY) NMR spectroscopic studies. Significant differences were observed between the structures of the AGT complexes with beta- and gamma-CD. [less ▲]

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See detailPulmonary perfusion redistribution in exercises horses
Votion, Dominique ULg; Harmegnies, N. F.; Duvivier, D. H. et al

in European Journal of Nuclear Medicine (2000), 41

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See detailSimilar Efficiency of DNA-Liposome Complexes and Retrovirus-Producing Cells for Hsv-Tk Suicide Gene Therapy of Peritoneal Carcinomatosis
Princen, Frederic; Lechanteur, Chantal ULg; Lopez, Marie-Josée ULg et al

in Journal of Drug Targeting (2000), 8(2), 79-89

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 ... [more ▼]

Several experimental approaches have been tested for suicide gene delivery into tumor cells, including viral and non-viral vectors. In this study, we compared the efficiency of Herpes Simplex Virus type 1 thymidine kinase gene (HSV-tk) delivery by retrovirus-producing cells and DNA/liposome complexes for the treatment of peritoneal carcinomatosis induced in syngeneic rats by DHD/K12 colorectal adenocarcinoma cells. After in vitro determination of the best transduction conditions, rats were treated with multiple intraperitoneal injections of plasmid DNA containing one or two copies of CMV-driven HSV-tk gene (pCMV-TK and p(CMV-TK)2, respectively) associated with LipofectAMINE, each injection being followed by a Ganciclovir (GCV) course. Animals treated by DNA/liposome complexes and GCV or with retrovirus-producing cells and GCV showed a similar increase of survival as compared to the control group. After DNA/ liposome injections, expression of the tk transgene was detected in tumor nodes (epiploon) and also in liver, lung, spleen, bowels and brain. The expression was not homogeneous throughout the different organs and most likely reflected the transfection of only a limited number of cells. [less ▲]

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See detailInitial Medical Management of Severe Acute Ulcerative Colitis
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Gastro-Enterologica Belgica (2000), 63(3, Jul-Sep), 275-8

Severe colitis is life-threatening complication of ulcerative colitis. Early recognition of the severity of the colitis, intensive medical therapy and prompt surgery when necessary have all contributed to ... [more ▼]

Severe colitis is life-threatening complication of ulcerative colitis. Early recognition of the severity of the colitis, intensive medical therapy and prompt surgery when necessary have all contributed to improved outcome. Initial medical treatment should be instituted as soon as the diagnosis is made with an intravenous corticosteroid associated with supportive treatment. If the patient fails to response to this intensive treatment after 5-7 days, cyclosporin should be initiated. If cyclosporin is not used then colectomy should be performed immediately. Moreover, significant deterioration at any point during medical therapy is an indication for colectomy. The gravity of the patient's condition require close interaction between physician an surgeon. [less ▲]

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See detailEducation pour le troisième millénaire : mes craintes, mes espoirs ... pour l’Université
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (2000), (259), 18-19

Courte réflexion sur les défis de l'Université en termes de formation au début du XXIe siécle

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See detailFormes et formalités. Remarques sur la poétique du nom chez Mallarmé
Durand, Pascal ULg

in Formules (2000), 4

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See detailMultivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis.
Fotsing, Lucas; Boulanger, Bruno ULg; Chiap, Patrice ULg et al

in Biomedical Chromatography : BMC (2000), 14(1), 10-1

Multivariate optimization approach for the separation of water-soluble vitamins and related compounds by capillary electrophoresis.

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