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See detailBiochemical Study of Collagen in Adult Groin Hernias
Pans, Alain ULg; Albert, Adelin ULg; Lapiere, C. M. et al

in Journal of Surgical Research (2001), 95(2), 107-13

BACKGROUND: Previous works have suggested that a defect in collagen fiber structure may play a role in inguinal hernia formation. These studies focused mainly on the rectus sheath or the skin, while only ... [more ▼]

BACKGROUND: Previous works have suggested that a defect in collagen fiber structure may play a role in inguinal hernia formation. These studies focused mainly on the rectus sheath or the skin, while only few reports dealt with the transversalis fascia. According to these findings and to our previous biomechanical and histological studies suggesting that a connective tissue pathology could play a role in the genesis of groin hernias, we performed a biochemical investigation of the collagen in the transversalis fascia and rectus sheath. MATERIALS AND METHODS: The samples were collected from 40 adult patients with uni- or bilateral hernias and from 20 control subjects without hernia (autopsies and organ donors). A constant area of tissue was taken by using a calibrator. The wet and dry weights per 100 mm(2) were determined and the total collagen concentration as well as its sequential extractibility in NaCl, acetic acid, and pepsin was measured. The ratios of alpha(1)/alpha(2) chains (I) and of type I/III collagen were assessed by polyacrylamide gel electrophoresis. RESULTS: Samples collected in the control and patient sheaths showed an increased wet weight per 100 mm(2) in the patients. The wet and dry weights per unit area were increased in the patient fascias. The collagen concentration was increased in the indirect hernias. The fascias from the direct hernias (DH) presented a significantly increased collagen extractibility after pepsin digestion (5.6%), when compared to the control fascias (2.6%). The extractibility was 3.4% in the nonherniated (NH) sides. The qualitative study (ratios alpha(1)/alpha(2) (I) and I/III collagen) showed no difference between the fascia groups. CONCLUSIONS: The significant increase of collagen extractibility with pepsin in the DH fascias and at a lesser degree in the NH fascias suggests that molecular alterations of collagen could be involved in the genesis of groin hernias. This connective tissue pathology would express preferentially its effects in the inguinal region, since we have observed no major difference between the rectus sheaths of controls and those of patients. [less ▲]

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See detailEffect of the 585 Nm Flashlamp-Pumped Pulsed Dye Laser for the Treatment of Keloids
Paquet, Philippe ULg; Hermanns, Jean-François ULg; Pierard, Gérald ULg

in Dermatologic Surgery (2001), 27(2), 171-4

BACKGROUND: Due to its potential effects on skin microcirculation and collagen metabolism, the 585 nm flashlamp-pumped pulsed dye laser has been proposed for treating abnormal scars. Indeed, one of the ... [more ▼]

BACKGROUND: Due to its potential effects on skin microcirculation and collagen metabolism, the 585 nm flashlamp-pumped pulsed dye laser has been proposed for treating abnormal scars. Indeed, one of the main problems with keloidal scars is their disfiguring erythematous color. OBJECTIVE: To assess the efficacy of the 585 nm pulsed dye laser on the appearance of keloids. METHODS: Eleven patients with skin phototypes II-IV and keloids were treated with the 585 nm pulsed dye laser. After one to three treatment sessions, clinical assessments of the scars were performed in combination with remittance spectroscopy measurements of the redness and melanin pigmentation. A group of nine keloids covered by silicone gel sheeting served as controls. Data were compared statistically. RESULTS: During laser treatments, a discrete decrease in redness of the scars was clinically reported. However, this improvement was not confirmed by the objective spectrophotometric data. No side effects, especially hyperpigmentation, were disclosed. The keloids redness was not improved in the control group. CONCLUSION: The 585 nm pulsed dye laser yields only minimal effects, if any, on the erythema of keloids. Similarly silicone gel sheeting does not modify the keloids redness. [less ▲]

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See detailSeuil liminaire de la perception d'un etirement cutane
Martalo, O.; Henry, Frédérique ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2001), 128(2), 119-22

BACKGROUND: Cutaneous sensorial perception is complex and proves to be difficult to quantify. Skin sensitivity to mechanical distension is largely unexplored. We have developed an original method aimed at ... [more ▼]

BACKGROUND: Cutaneous sensorial perception is complex and proves to be difficult to quantify. Skin sensitivity to mechanical distension is largely unexplored. We have developed an original method aimed at quantifiying these physiological parameters.VOLUNTEERS AND METHODS: The study was performed on 24 adult volunteers aged 20 to 50 years. A Cutometer SEM 474 equipped with 2 and 4 mm diameter probes was used to exert a progressive or a steep suction on the cheeks. The intensities of both the suction and the skin deformation observed at the earliest moment the traction was perceived by the volunteers were recorded.RESULTS: The liminar sensorial detection under progressive suction force was 1.5 times lower when using the 4 mm probe than the 2 mm probe. Suction necessary for liminar sensation was 7 times lower under steep suction than in response to the progressive mode. The skin deformation corresponding to the liminar sensorial perception was almost constant (C=0.5 p. 100) for each subject. By contrast, a large inter individual heterogeneity unrelated to age was present.COMMENTS: Sensitivity of facial skin to stretching can be explored using a precise suction method. Perception is more related to the rate of traction than to the surface area submitted to suction. Cutaneous deformation, nearly constant for each individual, appears to be the main parameter. Steep and progressive suctions appear to stimulate distinct types of mechanoreceptors. The presently described method can be applied in cosmetology and in functional investigation of various diseases such as diabetes, acromegaly and atopic dermatitis among others. [less ▲]

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See detailAcute encephalopathy despite early therapy in a patient with homozygosity for E365K in the glutaryl-coenzyme A dehydrogenase gene
Kölker, S.; Ramaekers, Vincent ULg; Zschocke, J. et al

in Journal of Pediatrics (2001), 138(2), 277-279

A patient with glutaric aciduria type I had an acute encephalopathic crisis despite early treatment. This report indicates that current therapeutic strategies may be insufficient for some high-risk ... [more ▼]

A patient with glutaric aciduria type I had an acute encephalopathic crisis despite early treatment. This report indicates that current therapeutic strategies may be insufficient for some high-risk patients and stresses the demand for new approaches in glutaric aciduria type I. [less ▲]

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See detailPharma clinics. Comment je traite.... L'arthrose. 1ère partie: Rappel physiopathologique et traitement symptomatique
Reginster, Jean-Yves ULg; Henrotin, Yves ULg

in Revue Médicale de Liège (2001), 56(2), 63-7

Osteoarthritis is now considered in all developed countries as a major burden for public health. During several years, the pharmacological management of osteoarthritis mainly focused on symptoms relief ... [more ▼]

Osteoarthritis is now considered in all developed countries as a major burden for public health. During several years, the pharmacological management of osteoarthritis mainly focused on symptoms relief without interaction with the long-term structural progression of this disease. Based on recently published consensus, the present article summarizes the currently available options in the symptom-modifying management of osteoarthritis. [less ▲]

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See detailDisruption of CIC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
Stobrawa, SM; Breiderhoff, T; Takamori, S et al

in Neuron (2001), 29(1), 185-96

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See detailInstallations fixes soumises à permis d'urbanisme en Région wallonne
Delnoy, Michel ULg

in Immobilier (2001), 1

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See detailCross-Sectional Study of the Association between Pathological Conditions and Myxoma-Virus Seroprevalence in Intensive Rabbit Farms in Europe
Marlier, Didier ULg; Herbots, J.; Detilleux, Johann ULg et al

in Preventive Veterinary Medicine (2001), 48(1), 55-64

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily ... [more ▼]

Myxomatosis is a major viral disease of the European rabbit (Oryctolagus cuniculus). Two forms of the disease (nodular and amyxomatous) exist. The clinical diagnosis of the nodular form is easily performed on the basis of typical skin lesions whereas that of amyxomatous forms must be based on virus isolation or detection of specific antibodies to myxoma virus (MV). The seroprevalence of MV was studied between March 1998 and February 1999 in 16 farms from three European countries considered free of myxomatosis on the basis of the absence of typical clinical signs. MV antibodies were detected by enzyme-linked immunosorbent assay (ELISA) (sensitivity 100%, specificity 90%) in all 16 farms; the seroprevalences corrected for test inaccuracy (95% confidence interval) were 55+/-7.7% and 37+/-6.1% for does and broilers, respectively. The association between herd sizes, types of rabbitries, and presence of recurrent respiratory or digestive troubles and seroprevalence of MV antibodies was tested in logistic multiple regressions. In all models, the seroprevalence of MV antibodies was significantly higher in herds (does and broilers) with recurrent respiratory or digestive troubles than in herds without these problems. The seroprevalence was also higher in herds (does and broilers) where animals were housed totally or partially in outdoors rabbitries than in totally enclosed rabbitries. The effect of herd sizes on the presence of MV antibodies was the same in does and broilers; intermediate sizes were at lower risk than the smaller and larger ones. [less ▲]

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See detailPoly (ε-caprolactone-b-glycolide) and Poly(D,L-lactide-b-glycolide) diblock copolyesters: controlled synthesis, characterization, and colloidal dispersions
Barakat, Ibrahim; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (2001), 39(2), 294-306

Living -aluminum alkoxide poly--caprolactone and poly-D,L-lactide chains were synthesized by the ring-opening polymerization of -caprolactone (-CL) and D,L-lactide (D,L-LA), respectively, and were used as ... [more ▼]

Living -aluminum alkoxide poly--caprolactone and poly-D,L-lactide chains were synthesized by the ring-opening polymerization of -caprolactone (-CL) and D,L-lactide (D,L-LA), respectively, and were used as macroinitiators for glycolide (GA) polymerization in tetrahydrofuran at 40 °C. The P(CL-b-GA) and P(LA-b-GA) diblock copolymers that formed were fractionated by the use of a selective solvent for each block and were characterized by 1H NMR spectroscopy and differential scanning calorimetry analysis. The livingness of the operative coordination-insertion mechanism is responsible for the control of the copolyester composition, the length of the blocks, and, ultimately, the thermal behavior. Because of the inherent insolubility of the polyglycolide blocks, microphase separation occurs during the course of the sequential polymerization, resulting in a stable, colloidal, nonaqueous copolymer dispersion, as confirmed by photon correlation spectroscopy. [less ▲]

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See detailNonradial nonadiabatic stellar pulsations: A numerical method and its application to a beta Cephei model
Dupret, Marc-Antoine ULg

in Astronomy and Astrophysics (2001), 366

A new general method for the computation of nonradial nonadiabatic oscillations of a given stellar model is presented for a linear approximation. A simple and useful modelling of the atmosphere is ... [more ▼]

A new general method for the computation of nonradial nonadiabatic oscillations of a given stellar model is presented for a linear approximation. A simple and useful modelling of the atmosphere is included, allowing to obtain credible values for the eigenfunctions in the atmosphere. Some of the results obtained for a 10 M[SUB]sun[/SUB] model are shown as an illustration. Our study opens the way to different applications. Better theoretical line-profile variations could be obtained from our method, allowing a more detailed comparison with observations. More generally, our study is relevant for asteroseismology, giving a way for a better knowledge of stellar interiors. [less ▲]

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See detailHigh resolution X-ray spectroscopy of zeta Puppis with the XMM-Newton reflection grating spectrometer
Kahn, S. M.; Leutenegger, M. A.; Cottam, J. et al

in Astronomy and Astrophysics (2001), 365

We present the first high resolution X-ray spectrum of the bright O4Ief supergiant star zeta Puppis, obtained with the Reflection Grating Spectrometer on-board XMM-Newton. The spectrum exhibits bright ... [more ▼]

We present the first high resolution X-ray spectrum of the bright O4Ief supergiant star zeta Puppis, obtained with the Reflection Grating Spectrometer on-board XMM-Newton. The spectrum exhibits bright emission lines of hydrogen-like and helium-like ions of nitrogen, oxygen, neon, magnesium, and silicon, as well as neon-like ions of iron. The lines are all significantly resolved, with characteristic velocity widths of order 1000-1500 km s[SUP]-1[/SUP]. The nitrogen lines are especially strong, and indicate that the shocked gas in the wind is mixed with CNO-burned material, as has been previously inferred for the atmosphere of this star from ultraviolet spectra. We find that the forbidden to intercombination line ratios within the helium-like triplets are anomalously low for N VI, O VII, and Ne IX. While this is sometimes indicative of high electron density, we show that in this case, it is instead caused by the intense ultraviolet radiation field of the star. We use this interpretation to derive constraints on the location of the X-ray emitting shocks within the wind that are consistent with current theoretical models for this system. [less ▲]

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See detailOptical variability of the B-type star HD 105382: Pulsation or rotation?
Briquet, Maryline ULg; Aerts, C.; De Cat, P.

in Astronomy and Astrophysics (2001)

We present ground-based multi-colour Geneva photometry and high-resolution high S/N spectra of the variable B-type star HD 105382. We provide evidence that this star is not a Be star, as indicated in the ... [more ▼]

We present ground-based multi-colour Geneva photometry and high-resolution high S/N spectra of the variable B-type star HD 105382. We provide evidence that this star is not a Be star, as indicated in the literature. The monoperiodic variability found in the Hipparcos data is confirmed in our ground-based follow-up observations. All existing data give rise to the detection of the period of 1.295 days. We try to interpret the variability of the star in terms of a non-radial g-mode pulsation model and of a rotational modulation model. None of these two is able to explain the observed line-profile variations in full detail. Based on observations obtained with the Swiss photometric telescope and ESO's CAT/CES telescope, both situated at La Silla, Chile. [less ▲]

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See detailAvalanches of Popping Bubbles in Collapsing Foams
Vandewalle, Nicolas ULg; Lentz, J. F.; Dorbolo, Stéphane ULg et al

in Physical Review Letters (2001), 86(1), 179-82

We report acoustic measurements of popping bubbles during the collapsing of aqueous foams. The sound pattern is analyzed using classical methods of statistical physics. It is found that membrane rupture ... [more ▼]

We report acoustic measurements of popping bubbles during the collapsing of aqueous foams. The sound pattern is analyzed using classical methods of statistical physics. It is found that membrane rupture concerns a wide variety of situations: small and large membranes at the air/foam interface. Avalanches of popping bubbles are put into evidence. Time durations in between successive pops seem to be distributed on a universal power law. [less ▲]

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See detailUn Centre de Jour pour une prise en charge de patients Alzheimer à un stade débutant
Lekeu, Françoise ULg; Salmon, Eric ULg

in Revue Médicale de Liège (2001), 56(1), 31-37

Alzheimer's disease represents an important problem for our societies, both in social and economical dimensions. Built in July 1997, the day care center of Liege aims at practicing strategic cognitive ... [more ▼]

Alzheimer's disease represents an important problem for our societies, both in social and economical dimensions. Built in July 1997, the day care center of Liege aims at practicing strategic cognitive interventions in early Alzheimer patients or when pathological memory impairments occur. By means of an interdisciplinary work (by neuropsychologists and occupational therapists), the ultimate goal of the interventions is to facilitate the patient's autonomy in activities of daily living. Because of the variability of clinical symptoms of the disease, the goal of these cognitive interventions is to optimize the performance of each patient by making the most of its preserved abilities. Moreover, another goal of the day care center is also to support the caregivers, by giving them advices in order to adequately face with difficulties presented by the patient. [less ▲]

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See detailStrychnogucines a and B, Two New Antiplasmodial Bisindole Alkaloids from Strychnos Icaja
Frederich, Michel ULg; De Pauw-Gillet, Marie-Claire ULg; Prosperi, Christelle ULg et al

in Journal of Natural Products (2001), 64(1), 12-16

A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by ... [more ▼]

A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM against the W2 strain). In addition, this compound showed a selective antiplasmodial activity with 25-180 times greater toxicity toward P. falciparum, relative to cultured human cancer cells (KB) or human fibroblasts (WI38). [less ▲]

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See detailA Fictional and Cultural Labyrinth: Caryl Phillips's The Nature of Blood
Ledent, Bénédicte ULg

in Ariel : A Review of International English Literature (2001), 32(1), 185-195

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See detailLe système du juge unique pour le règlement d’un problème multiple : l’encombrement de la Cour de Justice des Communautés européennes et du Tribunal de Première Instance
Munoz, Rodolphe ULg

in Revue du Marché Commun et de l'Union Européenne (2001), 444

La première partie de l’article examine la décision du Conseil du 26 avril 1999 donnant au Tribunal de Première Instance (TPI) la possibilité de siéger avec un juge unique: cette décision précise les ... [more ▼]

La première partie de l’article examine la décision du Conseil du 26 avril 1999 donnant au Tribunal de Première Instance (TPI) la possibilité de siéger avec un juge unique: cette décision précise les conditions de nomination et les pouvoirs de ce juge unique, les conditions d’application du système, et les cas où l’établissement d’un juge unique serait interdit. La seconde partie de l’analyse montre que l’effet concret du système sera limité en raison des limitations inscrites dans le texte même, et que le pouvoir procédural des Etats membres se trouve une nouvelle fois renforcé. Par ailleurs, l’analyse met en évidence les problèmes de fond soulevés par la fin du principe de collégialité et par la définition d’affaire ʺd’importance limitéeı Une dernière partie présente des propositions alternatives et cumulatives pour réformer le règlement de la procédure du TPI et de la Cour de Justice sans réformer l’ensemble du système juridictionnel. [less ▲]

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See detailImaging in Vivo Herpes Simplex Virus Thymidine Kinase Gene Transfer to Tumour-Bearing Rodents Using Positron Emission Tomography And
Hustinx, Roland ULg; Shiue, C. Y.; Alavi, A. et al

in European Journal of Nuclear Medicine (2001), 28(1), 5-12

Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex virus thymidine kinase (HSVtk) expression. This study evaluated the use of positron emission tomography ... [more ▼]

Radiolabelled ganciclovir analogues have shown promise as imaging agents to detect herpes simplex virus thymidine kinase (HSVtk) expression. This study evaluated the use of positron emission tomography (PET) imaging with 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) to assess gene transfer into tumours. HSVtk-positive and HSVtk-negative cell lines were first treated in vitro with [18F]FHPG. To assess the efficacy of PET in detecting HSVtk expression following in vivo gene transfer, mice were injected intravenously with an adenovirus encoding HSVtk (Ad.HSVtk), a control vector (Ad.Bgl2) or saline. Subcutaneous human glioma xenografts were grown in mice and treated by direct injection of Ad.HSVtk or Ad.Bgl2. Imaging was performed 48 h after transduction. Similar experiments were performed using Fischer rats implanted with syngeneic tumours. The presence of the HSVtk protein was confirmed by immunohistochemistry. Biodistribution studies were also obtained in 14 naive mice. In vitro studies showed high and specific uptake of [18F]FHPG in HSVtk-positive cell lines, with an uptake ratio of up to 27:1. PET imaging and direct counting of major organs demonstrated HSVtk-specific tracer retention. In mice, HSVtk-positive tumours retained 3.4% dose/gram as compared to 0.6% for control tumours (P=0.03). They were clearly seen on the PET images as early as 100 min post injection. Similar results were obtained with syngeneic rat tumours. Biodistribution studies demonstrated the rapid distribution and clearance of the tracer in all major organs. Our results demonstrate that PET imaging of HSVtk gene transfer to tumours is feasible and is highly specific for HSVtk expression. [less ▲]

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See detailBonnes nouvelles des étoiles
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2001), 6

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See detailMulticriteria and Multiple Actors Tool Aiding to Optimise Building Envelope at the Architectural Sketch Design
Hauglustaine, Jean-Marie ULg; Azar, Sleiman

in Informatica (2001), 12(1), 3-24

The PC software AMCE is proposing building actors (owner, project authors… ) a Multiple Criteria Decision Aid procedure (MCDA) to optimise the building envelope about cost and energy performances, during ... [more ▼]

The PC software AMCE is proposing building actors (owner, project authors… ) a Multiple Criteria Decision Aid procedure (MCDA) to optimise the building envelope about cost and energy performances, during the sketch design. Two main modules are linked, where the user interactively goes: - the first one managers parameters describing the project requirements; - the graphic pen-based module allows to draw the sketch; it calculates geometric parameter values and put them back in the first module. Permanently informed on foreseeable performances, the user can any time search for optimal scenario giving best satisfaction (manoactor optimisation) or most preferred compromise (multiactors optimisation). [less ▲]

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See detailRapid and Reversible Inhibition of Brain Aromatase Activity
Balthazart, Jacques ULg; Baillien, M.; Ball, G. F.

in Journal of Neuroendocrinology (2001), 13(1), 63-73

Many actions of androgens require their conversion via the enzyme aromatase into oestrogens. Changes in brain aromatase activity are thought to take place via changes in enzyme concentration mediated by ... [more ▼]

Many actions of androgens require their conversion via the enzyme aromatase into oestrogens. Changes in brain aromatase activity are thought to take place via changes in enzyme concentration mediated by effects of sex steroids on aromatase transcription. These changes are relatively slow which fits in well with the fact that oestrogens are generally viewed as slow-acting messengers that act via changes in gene transcription. More recently, fast actions of oestrogens, presumably at the level of the cell membrane, have been described both in the female brain and in the male brain after the conversion of testosterone to oestradiol. It is difficult to reconcile the slow regulation of oestrogen synthesis (that occurs via changes in aromatase concentration) with a rapid action at the membrane level. Even if fast transduction mechanisms are available, this will not result in rapid changes in brain function if the availability of the ligand does not also change rapidly. Here, we report that aromatase activity in neural tissue of male Japanese quail (Coturnix japonica) is rapidly downregulated in the presence of Mg(2+), Ca(2+) and ATP in hypothalamic homogenates and in brain explants exposed to high Ca(2+) levels following a K(+)-induced depolarization or the stimulation of glutamate receptors. The K(+)-induced inhibition of aromatase activity is observed within minutes and reversible. Given that aromatase is present in presynaptic boutons, it is possible that rapidly changing levels of locally produced oestrogen are available for nongenomic regulation of neuronal physiology in a manner more akin to the action of a neuropeptide than previously hypothesized. [less ▲]

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See detailOngles sales et mycotoxines
Arrese, J. E.; Goffin, Véronique ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (2001), 56(1), 38-40

Some mycotoxins are among the most toxic natural products. They are metabolites produced by food-borne and feed-borne moulds. Dirty and soiled nails, and contaminated or infected onyxis by these specific ... [more ▼]

Some mycotoxins are among the most toxic natural products. They are metabolites produced by food-borne and feed-borne moulds. Dirty and soiled nails, and contaminated or infected onyxis by these specific moulds can be the origin of oral contamination and mycotoxicosis. Hence, nail cleaning, correct hygiene and treatment of mould onychomycosis have a potentially great impact on health. [less ▲]

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See detailMajor Decrease in the Incidence of Trisomy 21 at Birth in South Belgium: Mass Impact of Triple Test?
Verloes, Alain ULg; Gillerot, Y.; Van Maldergem, Lionel ULg et al

in European Journal of Human Genetics (2001), 9(1), 1-4

In South Belgium (Wallonia), the 'triple test' was introduced in 1990-1991, and is nowadays a widely accepted screening method for assessment of trisomy 21 risk in pregnancy. The 'triple test' is not ... [more ▼]

In South Belgium (Wallonia), the 'triple test' was introduced in 1990-1991, and is nowadays a widely accepted screening method for assessment of trisomy 21 risk in pregnancy. The 'triple test' is not regulated and can be freely performed by any biomedical lab, making epidemiological data unavailable. By contrast, cytogenetic investigations are limited to a few genetic centres, and accurate statistics can be easily built from their files. During the period 1984-1989, a total of 244 trisomy 21 (1/876 pregnancies) were diagnosed in the Genetic Centres of Liege and Loverval, 42 (17%) of them prenatally. During the period 1993-1998, 294 trisomy 21 (1/704 pregnancies) were observed, 165 (56%) of which prenatally, and more than 90% of affected pregnancies were terminated. Even after correction for late foetal loss of trisomic foetuses, the difference is highly significant, and corresponds to a theoretical shift in the incidence of trisomy 21 at birth from 1/794 to 1/1606. As no remarkable progress occurred in other non-invasive prenatal screening procedures or general health care policies in Belgium, the most reasonable explanation is the use on a large scale of triple test by pregnant women, and the election of termination for most affected pregnancies. [less ▲]

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See detailLa contribution des pouvoirs locaux à la réalisation des objectifs du Traité de Maastricht
Husson, Jean-François ULg

in Bulletin de Documentation du Ministère des Finances (2001), (1), 15-54

Due to is public finance position in the early 1990's, matching the deficit and debt criteria set by the Maastricht Treaty was not an easy task for Belgium. Efforts from all components of the public ... [more ▼]

Due to is public finance position in the early 1990's, matching the deficit and debt criteria set by the Maastricht Treaty was not an easy task for Belgium. Efforts from all components of the public sector were required and local government delivered important efforts on both deficit and debt, despite the fact that local government supervision is not a federal but well a regional task. This article explains how local government is articulated with other components of general government, details its achievments and provide some light on the political process. [less ▲]

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See detailIncreased Expression of Galectin-1 in Carcinoma-Associated Stroma Predicts Poor Outcome in Prostate Carcinoma Patients
van den Brule, Frederic; Waltregny, David ULg; Castronovo, Vincenzo ULg

in Journal of Pathology (The) (2001), 193(1), 80-7

Galectin-1, a member of the beta-galactoside-binding galectin family, is a pleiotropic dimeric protein participating in a variety of normal and pathological processes, including cancer progression ... [more ▼]

Galectin-1, a member of the beta-galactoside-binding galectin family, is a pleiotropic dimeric protein participating in a variety of normal and pathological processes, including cancer progression. Modulation of the interactions with the basement membrane glycoprotein laminin and induction of apoptosis in activated T lymphocytes are well-known functions of this galectin. In this study, the expression of galectin-1 was examined in 148 human primary prostate carcinoma samples. Immunohistochemical staining of paraffin sections of prostate tissues revealed that galectin-1 was not detected in normal, PIN (prostatic intraepithelial neoplasia) or carcinoma cells, but accumulated in the stroma and associated fibroblasts. Galectin-1 expression was significantly increased in the tumour-associated stroma compared with the non-neoplastic gland-associated stroma in 21.3% of the cases (Mantel-Haenszel test, p=0.001; Wilcoxon signed rank test, p<0.0001). Increased galectin-1 expression in the cancer-associated stroma compared to the normal gland-associated stroma (p=0.03) was identified by multivariate analysis as a strong independent predictor of prostate-specific antigen (PSA) recurrence, just after the pathological stage (p<0.0001). The association between accumulation of galectin-1 in the stroma of the malignant tissue and aggressiveness of the tumour adds weight to the body of evidence that identifies a role for galectin-1 in the acquisition of the invasive phenotype. In addition to modulating cancer cell interactions with laminin, galectin-1 accumulated around the cancer cells may act as an immunological shield by inducing activated T-cell apoptosis. This exciting hypothesis warrants further investigation. [less ▲]

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See detailLong-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Rovati, Lucio C et al

in Lancet (2001), 357

BACKGROUND: Treatment of osteoarthritis is usually limited to short-term symptom control. We assessed the effects of the specific drug glucosamine sulphate on the long-term progression of osteoarthritis ... [more ▼]

BACKGROUND: Treatment of osteoarthritis is usually limited to short-term symptom control. We assessed the effects of the specific drug glucosamine sulphate on the long-term progression of osteoarthritis joint structure changes and symptoms. METHODS: We did a randomised, double-blind placebo controlled trial, in which 212 patients with knee osteoarthritis were randomly assigned 1500 mg sulphate oral glucosamine or placebo once daily for 3 years. Weightbearing, anteroposterior radiographs of each knee in full extension were taken at enrolment and after 1 and 3 years. Mean joint-space width of the medial compartment of the tibiofemoral joint was assessed by digital image analysis, whereas minimum joint-space width--ie, at the narrowest point--was measured by visual inspection with a magnifying lens. Symptoms were scored by the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index. FINDINGS: The 106 patients on placebo had a progressive joint-space narrowing, with a mean joint-space loss after 3 years of -0.31 mm (95% CI -0.48 to -0.13). There was no significant joint-space loss in the 106 patients on glucosamine sulphate: -0.06 mm (-0.22 to 0.09). Similar results were reported with minimum joint-space narrowing. As assessed by WOMAC scores, symptoms worsened slightly in patients on placebo compared with the improvement observed after treatment with glucosamine sulphate. There were no differences in safety or reasons for early withdrawal between the treatment and placebo groups. INTERPRETATION: The long-term combined structure-modifying and symptom-modifying effects of gluosamine sulphate suggest that it could be a disease modifying agent in osteoarthritis. [less ▲]

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See detailDermatite actinique chronique severe traitee par ciclosporine: 2 cas
Paquet, Philippe ULg; Pierard, Gérald ULg

in Annales de Dermatologie et de Vénéréologie (2001), 128(1), 42-5

INTRODUCTION: The treatment of the severe forms of photodermatoses often requires potent systemic immunosuppressive drugs. We report two patients suffering from severe photodermatitis successfully treated ... [more ▼]

INTRODUCTION: The treatment of the severe forms of photodermatoses often requires potent systemic immunosuppressive drugs. We report two patients suffering from severe photodermatitis successfully treated with oral cyclosporine. CASES REPORT: A 58-year-old man developed severe pruritic eczematous reactions for several years on light-exposed and light-protected skin following each sun exposure. A 66-year-old man showed similar lesions restricted to the head and neck. The clinical presentation and evolution as well as histologic, immunohistologic, allergologic and photobiologic assessments suggested the diagnosis of actinic reticuloid and persistent light reactivity, respectively. The lesions of both patients did not respond to a high dose regimen of systemic corticosteroids (methylprednisolone 1 mg/kg/day) for several weeks. The severity of cutaneous lesions and pruritus required another potent immunosuppressive treatment. Oral cyclosporine at the maximum daily dose of 4 mg/kg was given for three months. A rapid improvement of the pruritus and skin lesions occurred in the two patients, without significant side-effect. The first patient experienced recurrent lesions after termination of cyclosporine treatment during summer time. The other patient did not develop new skin eruption for 3 years after stopping the initial treatment with cyclosporine. DISCUSSION: Low-dose oral cyclosporine is a quick-acting and well tolerated symptomatic treatment of severe photodermatoses resistant to other systemic immunosuppressive drugs. However, therapeutic results do not consistently exhibit long-standing remanent effect. [less ▲]

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See detailEffect of High Doses of Oral Risedronate (20 Mg/Day) on Serum Parathyroid Hormone Levels and Urinary Collagen Cross-Link Excretion in Postmenopausal Women with Spinal Osteoporosis
Zegels, Brigitte ULg; Eastell, R.; Russell, R. G. et al

in BONE (2001), 28(1), 108-12

The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without ... [more ▼]

The present study describes the biological effects of risedronate, a pyridinyl bisphosphonate, on bone and assesses the safety and tolerability of risedronate when given at high doses, with or without calcium, to postmenopausal women with spinal osteoporosis. This single-center descriptive, double-blind, placebo-controlled, randomized, parallel group study included 32 postmenopausal white women with at least one radiographically confirmed vertebral compression fracture. Patients were randomized to one of four different dose regimen groups: (i) R-P, risedronate 20 mg/day for 14 days, followed by placebo for 42 days; (ii) R-CP-P, risedronate 20 mg/day for 14 days, followed by elemental calcium 1000 mg/day and placebo for 14 days, then by placebo for 28 days; (iii) R-CP-R-CP, risedronate 20 mg/day for 7 days, followed by elemental calcium 1000 mg/day and placebo for 21 days, then risedronate 20 mg/day for 7 days, and finally elemental calcium 1000 mg/day and placebo for 21 days; and (iv) P, placebo for 56 days. The biological response was investigated by measuring serum calcium, parathyroid hormone (PTH), and 2 h urinary pyridinoline/creatinine (Pyr/Cr) and deoxypyridinoline/creatinine (DPyr/Cr) ratios at baseline and at days 3, 7, 14, 21, 28, 35, 42, 49, 56, and 84. Overall, there were no consistent trends observed between the active group and placebo for serum calcium. In groups R-P, R-CP-P, and R-CP-R-CP, mean serum PTH levels were elevated above baseline values for the entire 56 day treatment period and remained elevated, although to a lesser extent, at the day 84 follow-up visit. The effect of calcium supplementation on PTH was variable. Urinary Pyr/Cr and DPyr/Cr ratios were decreased from baseline over the entire study period in all groups receiving risedronate. The maximum observed percent decreases from baseline for Pyr/Cr and DPyr/Cr were -46.9% and -58.8%, respectively, at day 49 in the R-CP-R-CP group. In conclusion, risedronate given orally at a dose of 20 mg/day, continuously for 7 or 14 days, resulted in the expected biological response in osteoporotic women. The time course of changes in PTH levels following cessation of dosing was unaffected by calcium supplementation. There was no evidence of a PTH-mediated rebound in bone resorption following cessation of therapy. Furthermore, based on collagen cross-link data, patients did not show an excessive reduction in bone turnover. [less ▲]

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See detailLe cas clinique du mois. Intoxication aigue au methanol
Brasseur, Edmond ULg; Lemineur, T.; Leonard, Philippe ULg et al

in Revue Médicale de Liège (2001), 56(1), 7-10

We report a fatal methanol intoxication and discuss its physiopathology, diagnosis and treatment.

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See detailTherapeutic Drug Monitoring of Azathioprine and 6-Mercaptopurine Metabolites in Crohn Disease
Belaiche, Jacques ULg; Desager, J. P.; Horsmans, Y. et al

in Scandinavian Journal of Gastroenterology (2001), 36(1), 71-6

BACKGROUND: 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the ... [more ▼]

BACKGROUND: 6-Mercaptopurine (6-MP) and its prodrug azathioprine (AZA) have proven efficacy in the treatment of Crohn disease (CD). The immunosuppressive properties of AZA/6-MP are mediated by the intracellular metabolism of 6-MP into its active metabolites, 6-thioguanine nucleotides (6TGN) and 6methylmercaptopurine (6-MMP). Preliminary studies have suggested that the red blood cell concentration of 6TGN (RBC 6TGN) is a potential guide to therapy. The aims of the study were to evaluate the RBC 6TGN concentrations in adult patients with CD under long-term AZA/6-MP therapy and to correlate it with response to treatment and haematological parameters. METHODS: Twenty-eight CD patients treated for at least 3 months with AZA/6-MP were prospectively studied. Patients were separated into three main groups: group 1 (n = 19), corresponding to quiescent CD receiving AZA (dose: 2.05 +/- 0.4 mg/kg/day for a mean of 28.6 +/- 25 months) or 6-MP (dose: 1.4 +/- 01 mg/kg/day for a mean of 7.5 +/- 3.5 months) alone; group 2 (n = 6), corresponding to quiescent CD treated by AZA (dose: 2.14 +/- 0.5 mg/kg/day for a mean of 29.5 +/- 22 months) with oral steroids; and group 3 (n = 3), corresponding to active CD on AZA (dose: 1.94 +/- 0.6 mg/kg/day for a mean of 31.3 +/- 35 months) as the only treatment. An assessment was also made by merging groups 1 and 2 forming a larger group of patients (n = 25) defined by clinical remission and groups 2 and 3 forming a larger group of patients (n = 9), non-complete responders with AZA/6-MP alone. Crohn disease index activity (CDAI), blood samples for full blood count and differential white cell count and measurement of RBC 6TGN and 6-MMP concentrations were evaluated at inclusion and at 6 months (n = 17). RBC 6TGN were measured using high performance liquid chromatography (HPLC) on heparinized blood. RESULTS: The baseline characteristics of the three groups of patients were similar. There was no significant difference among the three groups of patients regarding the dose and the duration of immunosuppressive treatment. There was no significant difference between groups according to various parameters tested. Particularly, the median RBC 6TGN concentration at inclusion was similar in the three groups of patients (166 (105-688), 183 (90-261) and 160 (52-194) pmol/8 x 10(8) RBC, respectively). The majority of patients had no detectable level of 6-MMP metabolite, except for 3 patients. There was also no difference between merging groups. Furthermore, there was no significant correlation between RBC 6TGN concentrations and the various biological parameters tested except for the mean erythrocyte volume. At 6 months, all patients of group 1 remained in remission and median RBC 6TGN concentration remained stable. No side effects were observed. CONCLUSIONS: There is, contrary to preliminary studies, a broad overlap in RBC 6TGN levels as well as for haematological parameters in patients in remission or not and responders or not to AZA/6-MP therapy. This suggests, beside a variability in the metabolism of these drugs, the existence of complex mechanisms of action. Nevertheless, beside the use of RBC 6TGN determination to confirm compliance to therapy, this dosage could be useful in non-responding patients, allowing, in absence of leukopenia, to increase the dose of AZA/6-MP safely. [less ▲]

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See detailNon-Gaussian electrical fluctuations in a quasi-2d packing of metallic beads
Vandewalle, Nicolas ULg; Lenaerts, Cedric ULg; Dorbolo, Stéphane ULg

in Europhysics Letters [=EPL] (2001), 53(2), 197-201

The electrical properties of a two-dimensional packing of metallic beads are studied. Small mechanical perturbations of the packing lead to giant voltage fluctuations. Fluctuations are found to be non ... [more ▼]

The electrical properties of a two-dimensional packing of metallic beads are studied. Small mechanical perturbations of the packing lead to giant voltage fluctuations. Fluctuations are found to be non-Gaussian and seem to belong to Levy stable distributions. Anticorrelations have been also found for the sign of these fluctuations. [less ▲]

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See detailFractionated irradiation combined with carbogen breathing and nicotinamide of two human glioblastomas grafted in nude mice
SUN, Lin-Quan; BUCHEGGER, Franz; COUCKE, Philippe ULg et al

in Radiation Research (2001), 155(1),

This study addressed the potential radiosensitizing effect of nicotinamide and/or carbogen on human glioblastoma xenografts in nude mice. U-87MG and LN-Z308 tumors were irradiated with either 20 fractions ... [more ▼]

This study addressed the potential radiosensitizing effect of nicotinamide and/or carbogen on human glioblastoma xenografts in nude mice. U-87MG and LN-Z308 tumors were irradiated with either 20 fractions over 12 days or 5 fractions over 5 days in air-breathing mice, mice injected with nicotinamide, mice breathing carbogen, or mice receiving nicotinamide plus carbogen. The responses to treatment were assessed using local control and moist desquamation. In U-87MG tumors, the enhancement ratios (ERs) at the radiation dose required to produce local tumor control in 50% of the treated mice (TCD50) with nicotinamide and/or carbogen ranged from 1.13 to 1.24 for irradiation in 20 fractions over 12 days. In LN-Z308 tumors, the ERs at the TCD50 with nicotinamide and/or carbogen ranged from 1.22 to 1.40 for irradiation in 5 fractions over 5 days and from 1.11 to 1.30 in 20 fractions over 12 days, respectively. Skin injury was slightly enhanced, with ERs ranged from 1.06 to 1.15 when radiation was combined with carbogen and/or nicotinamide. Thus carbogen and nicotinamide can slightly improve the radiation response of human glioblastoma xenografts. [less ▲]

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See detailManagement of Difficult Intubation
Janssens, Marc ULg; Hartstein, Gary ULg

in European Journal of Anaesthesiology (2001), 18(1), 3-12

Appropriate airway management is an essential part of the anaesthetist's role. Difficult intubation, which can now be quantified using the 'Intubation Difficulty Scale', should be anticipated whenever ... [more ▼]

Appropriate airway management is an essential part of the anaesthetist's role. Difficult intubation, which can now be quantified using the 'Intubation Difficulty Scale', should be anticipated whenever possible. A strategy needs to be developed in order to anticipate problems. The first part of this paper reviews the different factors that contribute to make intubation and/or ventilation difficult. Problems with intubation (or ventilation of the lungs) can be caused by abnormal laryngeal structures (e.g. tumour, stenosis), or by difficulty in seeing the glottis. The clinical history will usually help identify the former problem, while physical examination of the airway is required to reveal either disproportion between the various structures of the airway (e.g. tongue, larynx), and/or difficulties in aligning the oral, pharyngeal, and laryngeal axes. The different techniques used to diagnose these problems are described. The second part of this paper summarizes the algorithms used by the anaesthetist when management of the airway is found difficult. Three situations are considered: (a) anticipated difficult intubation, for which awake fibreoptic intubation would appear to be the technique of choice in the majority of cases, (b) unforeseen difficult intubation in a patient whose lungs can be ventilated; here, various techniques for control of the airway will be briefly described, and (c) both tracheal intubation and lung ventilation are impossible; this is a life-threatening emergency, for which three solutions are proposed. These include use of the laryngeal mask airway, the Combitube, or transtracheal ventilation. These situations will be analysed with the aim of proposing management strategies that always guarantee the safety of the patient. [less ▲]

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See detailPolyploid formation in cotton is not accompanied by rapid genomic changes
Liu, B.; Brubaker, Cl.; Mergeai, Guy ULg et al

in Genome (2001), 44(3), 321-330

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See detailIleo-caecal actinomycosis: Report of a case simulating complicated inflammatory bowel disease
Postal, Alain; Detry, Olivier ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (2001), 64(4, Oct-Dec), 318-320

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans ... [more ▼]

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans. Actinomyces israelii rarely cause abdominal infections or actinomycosis. Abdominal actinomysosis is characterised by fistulae and abscesses and may mimic cancer or inflammatory bowel disease. Abdominal actinomycosis is difficult to diagnose preoperatively, and often require surgical removal of the diseased tissue, allowing pathologists for giving the definitive diagnosis, revealed by characteristic "sulfur granules". The authors report herein the case of a 47-year-old man who presented with diarrhoea and abdominal pain. Abdominal computed tomography evoked complicated inflammatory bowel disease and surgical procedure was decided. Laparoscopic exploration did not provide further significant information, and laparotomy with diseased bowel resection was performed. Pathology demonstrated "sulfur granules" and allowed the diagnosis of abdominal actinomycosis. This case demonstrated that abdominal actinomycosis should be included in the differential diagnosis when computed tomography shows an infiltrative and inflammatory mass. [less ▲]

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See detailScytalidium Dimidiatum Melanonychia and Scaly Plantar Skin in Four Patients from the Maghreb: Imported Disease or Outbreak in a Belgian Mosque?
Arrese, J. E.; Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(2), 183-5

Scytalidium dimidiatum is a geophilic dematiaceous, non-dermatophyte mould that can become a pathogen for plants and humans particularly in tropical and subtropical regions. We report 4 cases of S ... [more ▼]

Scytalidium dimidiatum is a geophilic dematiaceous, non-dermatophyte mould that can become a pathogen for plants and humans particularly in tropical and subtropical regions. We report 4 cases of S. dimidiatum onychomycosis presenting clinically as thickened and dark toenails. The skin of the soles was scaly. The time and location of the contaminations were uncertain. Indeed, the patients were ancient immigrants from the Maghreb to Belgium. They were also regularly travelling to their countries of origin. They were also often barefoot in the same Belgian mosque. The disease was unresponsive to current oral antifungal treatments. [less ▲]

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See detailThe effect of risedronate on hip fracture risk in elderly women with osteoporosis
Bensen, W; Eastell, R; Reginster, Jean-Yves ULg et al

in Journal of Rheumatology (2001), 28(S63), 24

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See detailIrradiation du petit bassin et fonction ano-rectale.
Gervaz, P; COUCKE, Philippe ULg; Gillet, M

in Gastroentérologie Clinique et Biologique (2001), 25

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus ... [more ▼]

Le traitement adjuvant des cancers du rectum a pour buts de stériliser la maladie résiduelle infra-clinique et d’améliorer le contrôle local. Depuis plus de 20 ans, des milliers de malades ont été inclus dans des études randomisées, visant d’abord à mettre en évidence un gain de survie et une réduction des récidives loco-régionales, en relation avec la radiothérapie pré- ou postopératoire, combinée ou non à la chimiothérapie. Les conséquences en termes de qualité de vie de ces traitements ont pourtant été peu étudiées, et la tolérance fonctionnelle du néo-rectum et de l’appareil sphinctérien à la radiothérapie restent mal connues [1]. Les difficultés liées à l’étude des effets de l’irradiation sur les tissus normaux, ainsi que la variabilité inter-individuelle de la réponse à la radiothérapie, s’ajoutent et rendent le sujet plus complexe encore. Les radiothérapeutes adaptent leur technique afin de réduire autant que possible la dose administrée aux tissus normaux avoisinant la tumeur. Dans le cas de l’irradiation du petit bassin, c’est l’intestin grêle qui a longtemps été considéré comme la structure à risque de complications, alors que l’atteinte du sphincter anal était rarement mentionnée [2]. Malgré les répercussions importantes de la dysfonction ano-rectale sur la qualité de vie des malades, l’atteinte du sphincter anal par la radiothérapie est restée un aspect négligé du traitement adjuvant des cancers du petit bassin [3]. Cet article a pour but, à travers une revue de la littérature, de mettre en évidence les effets qualitatifs et quantitatifs de la radiothérapie sur la fonction du sphincter anal, ainsi que de proposer une modification de la technique actuelle d’irradiation des cancers du bas rectum. [less ▲]

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See detailThe metropolis-hastings algorithm, a handy tool for the practice of environmental model estimation : illustration with the biochemical oxygen demand data
Torre, F.; Boreux, Jean-Jacques ULg; Parent, E.

in Cybergeo : Revue Européenne de Géographie = Cybergeo - European Journal of Geography (2001), 187

Environmental scientists often face situations where: (i) stimulus-response relationships are non-linear; (ii) data are rare or imprecise; (iii) facts are uncertain and stimulus-responses relationships ... [more ▼]

Environmental scientists often face situations where: (i) stimulus-response relationships are non-linear; (ii) data are rare or imprecise; (iii) facts are uncertain and stimulus-responses relationships are questionable.In this paper, we focus on the first two points. A powerful and easy-to-use statistical method, the Metropolis-Hastings algorithm, allows the quantification of the uncertainty attached to any model response. This stochastic simulation technique is able to reproduce the statistical joint distribution of the whole parameter set of any model. The Metropolis-Hastings algorithm is described and illustrated on a typical environmental model: the biochemical oxygen demand (BOD). The aim is to provide a helpful guideline for further, and ultimately more complex, models. As a first illustration, the MH-method is also applied to a simple regression example to demonstrate to the practitioner the ability of the algorithm to produce valid results. [less ▲]

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See detailAarabia, a new Early Devonian vascular plant from Africa (Morocco).
Gerrienne, Philippe ULg; Meyer-Berthaud, Brigitte

in Review of Palaeobotany and Palynology (2001), 116

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See detailThe short-range baryon baryon interaction in a chiral constituent quark model
Stancu, Floarea ULg; Glozman, Ya. L.

in Nuclear Physics A (2001), A683

The previous analysis of the short-range $NN$ repulsion originating from the Goldstone boson exchange hyperfine interaction between constituent quarks is revisited. We study in which respects the ... [more ▼]

The previous analysis of the short-range $NN$ repulsion originating from the Goldstone boson exchange hyperfine interaction between constituent quarks is revisited. We study in which respects the repulsion depends on the radial form of the spin-spin quark-quark force. We show that while the radial form affects the structure of the 6Q wave function, the short-range repulsion in the $NN$ system persists in any case. We extend our analysis to other $YN$ and $YY$ (flavor octet-octet) systems and demonstrate that the flavor-spin hyperfine interaction implies a short-range repulsion in these B=2 systems as well. [less ▲]

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See detailContrôle pharmacologique de l’hyperglycémie postprandiale
SCHEEN, André ULg; JANDRAIN, Bernard ULg; PAQUOT, Nicolas ULg et al

in Médecine et Hygiène (2001), 59

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See detailPalynology and sedimentology of laminites and tillites from the latest Famennian of the Parnaíba Basin, Brazil.
Streel, Maurice ULg; Caputo, M.V.; Loboziak, S et al

in Geologica Belgica (2001), 3(1-2), 87-96

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See detailTeloptosis, a Turning Point in Hair Shedding Biorhythms
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 203(2), 115-7

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from ... [more ▼]

The timing regulation of the hair growth phases is quite complex. We name teloptosis the termination of the telogen phase with hair shedding. The initiation of the next anagen I phase is independent from teloptosis. Both events are triggered by distinct factors. Indeed, teloptosis is the result of the loss of adhesion between cells of the club hair and those of its epithelial envelope. Teloptosis synchronization is perceived as telogen effluvium, related or not to shortening of the anagen phase. Subtle changes leading to early or delayed teloptosis affect hair density. It is possible to distinguish two types of telogen hairs on a trichogram. Those with an epithelial sheath indicate strong binding, suggesting early telogen, whereas the absence of an epithelial sheath indicates loose binding, conveying teloptosis. [less ▲]

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See detailShelf-slope exchanges associated with a steep submarine canyon off Calvi (Corsica, NW Mediterranean Sea): A modelling approach
Skliris, Nikos; Goffart, Anne ULg; Hecq, Jean-Henri ULg et al

in Journal of Geophysical Research (2001), 106(C9), 19883-19901

A three-dimensional, unsteady, nonlinear, high-resolution model is used to investigate the impact of the Calvi Canyon (NW Corsica) steep topography on the shelf-slope exchanges as well as on the ... [more ▼]

A three-dimensional, unsteady, nonlinear, high-resolution model is used to investigate the impact of the Calvi Canyon (NW Corsica) steep topography on the shelf-slope exchanges as well as on the circulation in the Calvi Bay in homogeneous winter and early spring conditions. A double σ coordinate system is considered in order to represent adequately the high depth gradients within the canyon. The studied region is under the influence of the West Corsica Current flowing northeastward along the NW Corsican coast (right-bounded flow). Model results show that the circulation in the Calvi Bay is determined by flow modifications in the canyon area. The mean horizontal flow is deviated southwestward upstream of the canyon to form an anticyclonic gyre in the western part of the Calvi Bay. Within the canyon the circulation is cyclonic leading to an offshore flow downstream of the canyon. Around the canyon rim, the cross-shelf currents become important, indicating that this region acts as a transition zone of high exchange between nearshore and offshore areas. Furthermore, the canyon topography generates high downwelling (upwelling) and downsloping (upsloping) velocities responsible for an intense vertical transport of material in the area. Numerical runs are performed for typical prevailing wind conditions. The wind is responsible for a drastic increase of cross-shore transports between the bay and the canyon area (3–4 times larger than in the no-wind case). SW winds induce a further enhancement of cross-shelf exchanges, whereas the effect of N-NE winds is to reduce exchange at the shelf break apart from the canyon head where an intense offshore flow occurs. Within the canyon, high vertical velocities are shown to be associated with high cyclonic vorticity which is enhanced (reduced) by the N-NE (SW) wind event. A comparison between model results and measured distributions of nitrate and chlorophyll a concentrations in the area shows the role played by this specific hydrodynamics as a strong constraint on the coastal pelagic ecosystem. [less ▲]

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See detailReduced gating of middle-latency auditory evoked potentials (P50) in migraine patients: another indication of abnormal sensory processing?
Ambrosini, A.; De Pasqua, Victor ULg; Afra, J. et al

in Neuroscience Letters (2001), 306(1-2), 132-4

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The ... [more ▼]

Habituation of cortical evoked responses to repetitive stimuli is reduced in migraine between attacks. To explore another aspect of information processing, we measured auditory sensory gating. The amplitude of the P50 response to the second of two homologous stimuli was significantly less reduced in migraineurs than in healthy volunteers. This lack of auditory sensory gating may be due to a hypofunction of monoaminergic subcortico-cortical pathways, which is also supposed to cause the interictal deficit of cortical habituation to repetitive stimuli. [less ▲]

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See detailFacial mimicry and emotional contagion to dynamic emotional facial expression and their influence on decoding accuracy
Hess, U; Blairy, Sylvie ULg

in International Journal of Psychophysiology (2001), 40

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See detailLes régimes d’épargne protéique dans le traitement de l’obésité
PAQUOT, Nicolas ULg

in Nutrition Clinique et Metabolisme (2001), 15

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See detailPositron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) for the staging of low-grade non-Hodgkin's lymphoma (NHL).
Jerusalem, Guy ULg; Beguin, Yves ULg; Najjar, F. et al

in Annals of Oncology (2001), 12(6), 825-30

BACKGROUND: Although PET has been shown to be highly sensitive in the primary staging of lymphoma, previous studies with small numbers of patients indicated that low-grade NHL may not always be adequately ... [more ▼]

BACKGROUND: Although PET has been shown to be highly sensitive in the primary staging of lymphoma, previous studies with small numbers of patients indicated that low-grade NHL may not always be adequately detected by PET. We undertook this study to determine factors influencing the detection of lesions by PET in low-grade NHL and to evaluate the utility of PET in this indication. PATIENTS AND METHODS: Forty-two patients underwent conventional staging procedures (clinical examination, oto-rhino-laryngologic examination, computed tomography of the chest, abdomen and pelvis, gastroscopy and bone marrow biopsy as well as whole-body non-attenuation corrected 18F-FDG-PET RESULTS: PET detected 40% more abnormal lymph node areas than conventional staging in follicular lymphoma but was inappropriate for the staging of small lymphocytic lymphoma where it detected less than 58% of abnormal lymph node areas. PET showed more lesions than conventional staging for peripheral (34% more lymph node areas detected) and thoracic lymph node (39% more) areas but not for abdominal or pelvic lymph nodes (26% fewer areas detected). The sensitivity to detect bone marrow infiltration was unacceptably low for PET. In contrast, PET was as effective as standard procedures for the detection of other extranodal localizations, although a few localizations were detected only by PET and a few others only by conventional procedures. CONCLUSIONS: PET may contribute to the management of patients with low-grade follicular NHL. For the other low-grade lymphoma subtypes, the role of PET is less evident. Further studies using PET to evaluate the results of treatment or to diagnose disease recurrence are warranted in low-grade follicular NHL. [less ▲]

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See detailEffect of Ketoconazole 1% and 2% Shampoos on Severe Dandruff and Seborrhoeic Dermatitis: Clinical, Squamometric and Mycological Assessments
Pierard-Franchimont, Claudine ULg; Pierard, Gérald ULg; Arrese, J. E. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2001), 202(2), 171-6

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was ... [more ▼]

Ketoconazole (KET) is active to control dandruff and seborrhoeic dermatitis. Objective assessments comparing the 1% and 2% shampoo formulations are scant. This open, randomized parallel-group trial was carried out to differentiate the effectiveness of KET 1% and 2% in severe dandruff and seborrhoeic dermatitis. A total of 66 patients with severe dandruff or seborrhoeic dermatitis were randomized to each of the two groups. A 2-week run-in phase was followed by a 4-week treatment phase, in turn followed by a 4-week follow-up. The efficacy of treatments was evaluated by combining squamometry X, Malassezia spp. counts and clinical assessments. After 2 and 4 weeks of treatment, KET 2% was significantly superior over KET 1% (p < 0.001) for decreasing both in flakiness and Malassezia density from baseline. The same trend was observed in the mean change from baseline in the overall dandruff severity score. Only 6 mild adverse events were reported. During follow-up KET 2% showed a trend to fewer relapses than KET 1%. KET 2% had superior efficacy compared to KET 1% in the treatment of severe dandruff and scalp seborrhoeic dermatitis. Biometrological evaluations were correlated with the clinical improvements and therefore useful to incorporate in future dandruff studies. [less ▲]

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See detailIsokinetic evaluation of hip strength muscle groups in unilateral lower limb amputees
Croisier, Jean-Louis ULg; Maertens De Noordhout, Benoît ULg; Maquet, Didier ULg et al

in Isokinetics & Exercise Science (2001), 9(4), 163-169

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order ... [more ▼]

The objectives of the study were to measure the isokinetic strength of the hip flexor-extensor and adductor-abductor muscle groups in unilateral lower limb amputees and to evaluate abnormalities in order to improve the usual rehabilitation programs. Thirty-three patients with unilateral lower limb amputation were included in this study; they served as their own controls, the amputated side being compared to the intact side. Using an isokinetic device, the relative peak torques (N.m by body weight), bilateral asymmetries and agonist/antagonist torque ratios were calculated for the hip flexor, extensor, adductor and abductor muscle groups. A significant reduction of mean concentric relative peak torque measured on the amputated limbs was generally observed when compared to the intact contralateral limb (p < 0.05). The mean percentage of relative peak torque decrease was greater for the extensors than for the flexors (33 +/- 20% and 22 +/- 23%, respectively, at 30degrees/s angular velocity), and for the abductors than for the adductors (23 +/- 22% and 11 +/- 19%, respectively, at 30degrees/s angular velocity). Furthermore, the flexor/extensor torque ratio was significantly increased for the amputated limb (for instance, 1.25 +/- 0.33 versus 1.09 +/- 0.25 for the intact limb at 30degrees/s). The reduction of the abductor/adductor ratio of the operated limb reached the level of statistical significance at 60degrees/s only (1.25 +/- 0.46 versus 1.07 +/- 0.36 for the intact limb). In conclusion, isokinetic testing revealed a significant reduction of the hip stabilizing muscle strength as a consequence of lower limb amputation. The more marked decrease of the strength of the abductor and extensor muscle groups, resulting in imbalances of the agonist/antagonist strength ratios should be taken into account to adapt the conventional rehabilitation programs. [less ▲]

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See detailEpisphalosomic Syndrome : A Mca Syndrome Ressembling Fanconi Anemia, with Increased Baseline Level of Chromosome Breaks but No Hypersensivity to Clastogens
Verloes, Alain ULg; JAMAR, Mauricette ULg; Dideberg, Vinciane ULg et al

in Annales de Génétique (2001), 44(2, Apr-Jun), 59-62

We describe a child with facial dysmorphism (trigonocephaly, epicanthus, upturned nose, small ears), thumb hypoplasia, micropenis, jejunal atresia and moderate mental retardation with dysphasia ... [more ▼]

We describe a child with facial dysmorphism (trigonocephaly, epicanthus, upturned nose, small ears), thumb hypoplasia, micropenis, jejunal atresia and moderate mental retardation with dysphasia. Cytogenetic workup revealed high spontaneous level of chromosomal aberrations (without specific pattern and no quadriradial figures) and borderline to absent hypersensitivity to mitomycin C, making a diagnosis of Fanconi anemia unlikely. The child described here shares similarities with a small number of previous reports. We suggest to refer to this entity as episphalosomic syndrome. Episphalosomic syndrome shows some clinical overlap with Fanconi anemia, but lacks its cytogenetic hallmark. The hematological complications of Fanconi anemia have not been reported in this entity. [less ▲]

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See detailLe cas clinique du mois. Remplacement complet de l'aorte ascendante et de la crosse aortique dans un cas de dissection aortique chronique
DURIEUX, Rodolphe ULg; RADERMECKER, Marc ULg; GRENADE, Thierry ULg et al

in Revue Médicale de Liège (2001), 56(3), 140-3

We report the case of a patient who developed an evolutive chronic aortic dissection after ascending aorta replacement for acute type A aortic dissection. Owing to the development of severe aortic ... [more ▼]

We report the case of a patient who developed an evolutive chronic aortic dissection after ascending aorta replacement for acute type A aortic dissection. Owing to the development of severe aortic regurgitation, aortic root pseudoaneurysm and aneurysmal dilatation of the arch and descending aorta, reoperation was adviced. Reoperation included Cabrol modification of the Bentall operation and aortic arch replacement with elephant trunk performed under deep hypothermic circulatory arrest. The incidence of late aneurysmal formation in type 1 aortic dissection has been reported to be 30%. Close postoperative follow-up of the aortic diameter is necessary to detect a critical dilatation and to permit elective reoperation. [less ▲]

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See detailDistance correlations and dynamics of liquid GeSe: An ab initio molecular dynamics study
Raty, Jean-Yves ULg; Godlevsky, V. V.; Gaspard, Jean-Pierre ULg et al

in Physical Review. B, Condensed Matter and Materials Physics (2001), 64

We analyze the structure and dynamics of semiconducting liquid GeSe using ab initio molecular-dynamics simulations. We show the local order of the liquid to be close to that of the low-temperature ... [more ▼]

We analyze the structure and dynamics of semiconducting liquid GeSe using ab initio molecular-dynamics simulations. We show the local order of the liquid to be close to that of the low-temperature crystalline phase. alpha -GeSe. In particular, we show that the Peierls distortion, which defines the a phase and vanishes in the high-temperature beta crystalline phase, reenters GeSe in the melt. Examining the distance histograms allows one to analyze the Ge environment as consisting of a Gese(3) unit and having one Ge-Ge defective bond. Evidence is presented that Peierls distortion is directly responsible for the semiconducting behavior of the melt. The calculated viscosity and electrical conductivity are in agreement with the experiment. An additional neutron-diffraction experiment indicates that this liquid structure is unmodified 200 K above the melting point. [less ▲]

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See detailFaut-il bannir l’épicéa au nom de la gestion durable ?
Claessens, Hugues ULg

in Forêt Wallonne (2001), 49-50

L'épicéa (Picea abies (L.) Karst.), introduit en 1810 dans la sylviculture belge, est devenu en un siècle la première essence du pays, couvrant près de 200 000 ha et participant largement au développement ... [more ▼]

L'épicéa (Picea abies (L.) Karst.), introduit en 1810 dans la sylviculture belge, est devenu en un siècle la première essence du pays, couvrant près de 200 000 ha et participant largement au développement socio-économique des régions rurales du pays et en particulier de l'Ardenne. Mais pour des raisons liées à la mauvaise décomposition de sa fane et à son ombrage, sa culture en futaie pure équienne dense remplit mal les fonctions écologiques de la forêt. Dans toute l'Europe occidentale, confrontée à ce même problème, naît alors une polémique entre les milieux écologistes et les sylviculteurs de l'épicéa : la culture de l'épicéa peut-elle s'envisager dans le cadre de la gestion durable? Dans ce contexte, cette réflexion s'appuie sur les études scientifiques de l'impact de la pessière sur l'environnement ainsi que sur les recherches en matière de sylvicultures alternatives pour montrer qu'une sylviculture raisonnée de l'épicéa, dans les conditions qui lui conviennent, est compatible avec la gestion durable, mais aura probablement comme conséquence une diminution de la surface de la pessière. Afin d'ancrer, notre réflexion sur des études concrètes, notre démonstration fait référence à la pessière belge. [less ▲]

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See detailLa démocratie : utopie ou projet ? Balibar, Negri, Spinoza
Herla, Anne ULg

in Cahiers Internationaux de Symbolisme (2001), 98-99-100

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See detailLe cas clinique du mois. Maladie de Von Hippel-Lindau.
Gaspar, Y.; de Leval, Jean ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2001), 56(2), 68-71

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral ... [more ▼]

VHL disease is a rare genetical disease with a poor long-term prognosis. Clinical features include retineous angiomas, CNS hemangioblastomas, pheochromocytomas and renal cysts. Renal cysts are bilateral and frequently lead to malignant transformation. Surgical treatment of renal cysts is preferably delayed until a minimum of 3 cm diameter has been reached. Treatment has to be as conservative as possible, knowing that uni- or bilateral nephrectomy often has to be carried out later. [less ▲]

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See detailChromogenic detection of aminoglycoside phosphotransferases.
Amoroso, Ana Maria ULg; Gutkind, G. O.

in Methods in molecular medicine (2001), 48

Acquired resistance to aminoglycosides is most frequently due to the presence of the so-called aminoglycoside modifying enzymes (AGME) (1) able to catalyze one or more of three general reactions: N ... [more ▼]

Acquired resistance to aminoglycosides is most frequently due to the presence of the so-called aminoglycoside modifying enzymes (AGME) (1) able to catalyze one or more of three general reactions: N-acetylation, O-nucleotidylation and O-phosphorylation (2). Although resistance phenotype (to different (substrate or not for enzymatic modification) may serve as an approach for identifying actual enzymes present in a given isolate (3), results can be obscured or confusing, particularly when several different enzymes (4) (even, isoenzymes with different affinities) are superimposing their action in a single microorganism with potential "permeability" or target alterations. Thus, identification of the AGME content of a given strain also requires screening at the DNA level using probes specific to all the known AGME (5). However, the complete set of probes is available only to a few laboratories around the world, making surveillance for the appearance of novel enzymes, or the unlikely evolution of those already known, a relatively nonfeasible goal, as search for new enzymes may begin only after failing to hybridize to all known probes. [less ▲]

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See detailPiaget e Skinner : opposizioni e convergenze
Richelle, Marc ULg

in Età Evolutiva (2001), 70

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See detailTetraethyl(Pyrrolidine-2,2-diyl)Bisphosphonate
Olive, Gilles ULg; Jacques, Alain

in Molecules (2001), 6

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See detailSecular increase in the incidence of hip fractures in Belgium between 1984 and 1996: need for a concerted public health strategy.
Reginster, Jean-Yves ULg; Gillet, Pierre ULg; Gosset, Christiane ULg

in Bulletin of the World Health Organization (2001), 79(10), 942-6

OBJECTIVE: To determine the incidence of hip fractures (at the proximal end of the femur) in Belgium from 1984 to 1996. METHODS: Use was made of information from the national database on hospital bills ... [more ▼]

OBJECTIVE: To determine the incidence of hip fractures (at the proximal end of the femur) in Belgium from 1984 to 1996. METHODS: Use was made of information from the national database on hospital bills, which fully covers the annual hospital stays in the whole of the country. FINDINGS: The mean annual incidence of hip fractures increased from 107.8 to 140.5 per 100,000 inhabitants between 1984 and 1996. The incidence of fractures of the femoral shaft (diaphysis), taken as a control, remained stable. The female to male ratio of these hip fractures was 2.3:1. Although the incidence by age group was identical for males and females, the fractures occurred approximately seven years earlier in women than in men. The demographic changes observed in Belgium during this period accounted for only 10% of the observed increase in the number of hip fractures. CONCLUSION: If no comprehensive preventive policy is set up promptly, there will be a sevenfold increase in the incidence of hip fractures between now and the year 2050 in Belgium. [less ▲]

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See detailAnalysis Of The Chromosome Sequence Of The Legume Symbiont Sinorhizobium Meliloti Strain 1021
Capela, Delphine; Barloy-Hubler, Frédérique; Gouzy, Jérôme et al

in Proceedings of the National Academy of Sciences of the United States of America (2001), 98(17),

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See detailA simple tool to identify asian women at increased risk of osteoporosis.
Koh, L K; Sedrine, W B; Torralba, T P et al

in Osteoporosis International (2001), 12(8), 699-705

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available ... [more ▼]

Patients with low bone mineral density (BMD) have a high risk of future fractures, and should be actively considered for treatment to reduce their risk. However, BMD measurements are not widely available in some communities, because of cost and lack of equipment. Simple questionnaires have been designed to help target high-risk women for BMD measurements, thereby avoiding the cost of measuring women at low risk. However, such tools have previously focused on evaluation of non-Asian women. We collected information about numerous risk factors from postmenopausal Asian women in eight countries in Asia using questionnaires, and evaluated the ability of these risk factors to identify women with osteoporosis as defined by femoral neck BMD T-scores < or =-2.5. Multiple variable regression analysis and item reduction yielded a final tool based on only age and body weight. This risk index had a sensitivity of 91% and specificity of 45%, with an area under the curve of 0.79. Previously published risk indices based on larger numbers of variables performed similarly well in this Asian population. Large differences in risk were identified using our index to create three categories: 61% of the high-risk women had osteoporosis, compared with only 15% and 3% of the intermediate- and low-risk women, respectively. The low-risk group represented 40% of all women, for whom BMD measurements are probably not needed unless important risk factors, such as prior nonviolent fracture or corticosteroid use, are present. An existing population-based sample of postmenopausal Japanese women was used to validate our index. In this sample of Japanese women the sensitivity was 98% and specificity was 29%; the low-risk category, for whom BMD is probably unnecessary, represented 25% of all women. We conclude that our index performed well for classifying the risk of osteoporosis among postmenopausal Asian women and applying it would result in more prudent use of BMD technology. [less ▲]

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See detailNews on antifungal drugs registered in Belgium for the treatment of dermatophytosis in domestic carnivores.
Hamoir, J.; Goret, M.; Mignon, Bernard ULg et al

in Annales de Médecine Vétérinaire (2001), 145

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the ... [more ▼]

This note gives a progress report on the various molecules registered in Belgium which can be used for the treatment of dermatophytosis in domestic carnivores. Its purpose is not to develop the therapeutic protocols used in this type of diseases but rather to describe these compounds according to their pharmacological and toxicological characteristics as well as to define their status in the current legal framework. [less ▲]

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See detailPSA kinetics after external beam radiotherapy alone or combined with an iridium brachytherapy boost to deliver 85 grays to prostatic adenocarcinoma.
Nickers, Philippe ULg; Coppens, Luc ULg; Beauduin, M. et al

in Strahlentherapie und Onkologie (2001), 177(2), 90-5

PURPOSE: Increasing the dose to prostatic adenocarcinoma in conformal external beam therapy (EBT) has resulted in increased levels of PSA normalization and increased percentage of biochemical disease-free ... [more ▼]

PURPOSE: Increasing the dose to prostatic adenocarcinoma in conformal external beam therapy (EBT) has resulted in increased levels of PSA normalization and increased percentage of biochemical disease-free survival rates. However technical problems due to prostate motion inside the pelvis or patients' set-up make difficult the realization of the EBT boost fields above 72 Gy. Brachytherapy which overcomes these problems was investigated to deliver the boost dose to achieve 85 Gy. PSA nadir which has been identified as the strongest independent predictor of any failure in many studies has been used as the end point for early evaluation of this work. PATIENTS AND METHODS: In a retrospective way we report on 163 patients' PSA kinetics after EBT alone to 68 Gy or EBT first and a brachytherapy boost up to 75 or 85 Gy. RESULTS: At 12 months follow-up, PSA nadirs percentage < or = 0.5 or < or = 1 ng/ml increased from 7.5 and 20.7% after 68 Gy EBT to 49.8 and 71.2% after a brachytherapy boost to deliver 85 Gy (p < 0.0001). In the Cox PH model analysis, the total dose remained the most important factor for predicting PSA normalization. CONCLUSIONS: These results are in accordance with the most recent results published after conformal EBT at the same 80 Gy level of dose. If confirmed on a higher number of patients they could place brachytherapy among the most accurate methods of boosting in the radiation treatment of prostatic carcinoma. [less ▲]

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See detailThe dispositional inference strikes back: Situational focus and dispositional suppression in causal attribution
Yzerbyt, V. Y.; Corneille, O.; Dumont, Muriel ULg et al

in Journal of Personality & Social Psychology (2001), 81(3), 365-376

The authors propose that correction of dispositional inferences involves the examination of situational constraints and the suppression of dispositional inferences. They hypothesized that suppression ... [more ▼]

The authors propose that correction of dispositional inferences involves the examination of situational constraints and the suppression of dispositional inferences. They hypothesized that suppression would result in dispositional rebound. In Study 1, participants saw a video of either a free or a forced speaker. Participants shown a forced speaker later made stronger dispositional inferences about a 2nd, free speaker than control participants did. Study 2 provided evidence for higher rebound among participants who reported trying harder to suppress dispositional inferences during the Ist video. In Study 3, participants were asked to focus on situational constraints or to avoid thinking about the speaker's characteristics. Only the latter instructions led to a dispositional rebound. These data support the view that the correction of dispositional inferences involves 2 processes that lead to distinct consequences in subsequent attribution work. [less ▲]

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See detailÀ Stavelot-Malmedy entre 1080 et 1130. Cinquante ans de vie monastique revisités
George, Philippe ULg

in Bulletin des Bibliophiles liégeois (2001)

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See detailNotes sur la présence d'Indra dans le panthéon ârya
Swennen, Philippe ULg

in Studi Epigrafici e Linguistici sul Vicino Oriente Antico (2001), 18

The indo-iranian use of the compound adjective skt. haryaçva op. zariasba suggests that the god Indra was already known in the common ârya pantheon.

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See detailGenèse, évolution et multiples facettes d'une maladie inhabituelle affectant le hêtre en région wallonne
Huart, Olivier; Rondeux, Jacques ULg

in Forêt Wallonne (2001), 52

Les hêtraies wallonnes, principalement situées en Ardenne et en Gaume, sont victimes depuis près de 2 ans d'un problème sanitaire dont l'incidence au plan sylvicole et économique apparaît réellement ... [more ▼]

Les hêtraies wallonnes, principalement situées en Ardenne et en Gaume, sont victimes depuis près de 2 ans d'un problème sanitaire dont l'incidence au plan sylvicole et économique apparaît réellement catastrophique depuis le début de l'année 2001. Une recherche entamée mi-2000 a permis d'effectuer de très nombreuses observations et d'émettre diverses hypothèses quant à l'origine et au processus de développement d'une maladie mettant en jeu des champignons lignivores et des insectes ravageurs du bois. Cette recherche entre aujourd'hui dans sa seconde phase destinée non seulement à assurer le suivi méthodique de la maladie mais aussi à vérifier le bien-fondé des principales hypothèses émises concernant son origine et à cerner les mécanismes de propagation d'insectes dont les attaques n'ont cessé de croître depuis mars 2001. Ces attaques massives ont justifié la mise en place d'actions de recherche complémentaires et plus ciblées destinées à mieux comprendre la biologie des insectes incriminés et de proposer des moyens de lutte appropriés. Dans les lignes qui suivent nous présentons, sur la base d'observations menées depuis 10 mois, une analyse relativement fouillée de la situation en abordant successivement : l'historique de cette maladie, sa distribution, les symptômes les plus fréquemment observés ainsi que les agents causals, les axes prioritaires des recherches en cours, les conséquences tant économiques que sylvicoles et écologiques, et enfin les principaux moyens de lutte envisageable, compte tenu de l'état actuel des connaissances. [less ▲]

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See detailPresence of Oestrogen Receptor Type Beta in Human Retina
Munaut, Carine ULg; Lambert, Vincent ULg; Noël, Agnès ULg et al

in British Journal of Ophthalmology (2001), 85(7), 877-82

BACKGROUND/AIMS: Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences of expression among organs. Since ... [more ▼]

BACKGROUND/AIMS: Recent studies have demonstrated the existence of two oestrogen receptor subtypes alpha (ORalpha) and beta (ORbeta) with significant differences of expression among organs. Since important pathologies of human eye could be linked to hormonal status, the expression of ORbeta in ocular posterior segment was sought. METHODS: Immunohistochemical localisation of ORbeta and ORalpha protein and detection of OR mRNAs by reverse transcription-polymerase chain reaction (RT-PCR) were performed in macular and extramacular regions of the retina and in the choroid on male and female donors eyes. RESULTS: ORbeta protein was localised in the ganglion cell layer and in the choroid. At the transcriptional level, mRNA for ORbeta and for ORalpha were both present. Local differences in the expression level were observed, however, suggesting the possibility of variation in the ratio of ORalpha v ORbeta. CONCLUSIONS: The coexistence of two oestrogen receptor subtypes in the human ocular posterior segment raises acute questions about their potential physiological role, but offers a perspective for preferential targeting of a specific receptor subtype. [less ▲]

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See detailAdditive and dominance genetic variance of fertility by method R and preconditioned conjugate gradient
Druet, Tom ULg; Solkner, J.; Groen, A. F. et al

in Journal of Dairy Science (2001), 84(4), 9871-98716

The objectives of this study were threefold: 1) estimation of additive and dominance genetic variances for fertility traits for Austrian Simmental and Brown Swiss dairy cattle; 2) use of method R and the ... [more ▼]

The objectives of this study were threefold: 1) estimation of additive and dominance genetic variances for fertility traits for Austrian Simmental and Brown Swiss dairy cattle; 2) use of method R and the preconditioned conjugate gradient compared to solving for method R by second-order Jacobi iteration; and 3) study of the impact of inclusion of parental subclass effects on solutions for other random effects. Dominance variances were modeled for the inseminated cow and ranged from 0.32 to 1.36% of total variance. These values were similar to values for additive effects, which were approximately 1% of total variance. Convergence was clearly improved with preconditioned conjugate gradient and number of extrapolations reduced. Variance for permanent environment under a model without dominance could be split into a new estimate of permanent environmental variance and parental subclass variance. Solutions for parental subclass dominance effects were approximately proportional to permanent environment effects, but highly dependent on the number of animals contributing dominance relationships, especially full-sibs and three-quarter-sibs. For animals with a lot of dominance information (full-sibs, three-quarter-sibs, cousins), permanent environment and parental subclass dominance effects were nearly independent. Changes in additive effects were negligible, probably because both variances for parental subclass dominance effects and additive genetic effects were very small compared with residual variance. [less ▲]

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See detailChanges in lipoxygenase and hydroperoxide decomposition activity in tissues cultures of soybean
Fauconnier, Marie-Laure ULg; Mouttalib, A.; Billo, D. et al

in Journal of Plant Physiology (2001), 158(7), 953-955

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia ... [more ▼]

Glycine max L. tissue cultures were initiated on different media supplemented with appropriate plant growth regulators that specifically induce the formation of callus, root, or shoot primordia. Exogenously applied hormones resulted in important changes in both Lox and HPO decomposition activity. Lox activity was higher in extracts from tissues cultured in medium supplemented with NAA or 2,4-D, while a lowest activity was recorded in extracts from cultures treated with BA. 13-HPOD was cleaved by all tested extracts, while 13-HPOT and 9-HPOD were cleaved exclusively by extracts from tissues cultured in the presence of BA. [less ▲]

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See detailLes tourbières analysées en profondeur par le radar de subsurface.
Wastiaux, C; Halleux, L; Schumacker, R et al

in Hautes Fagnes (2001), 243

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See detailLe travailleur adoptant
Kefer, Fabienne ULg; Barth, D.

in Actualités du Droit (2001)

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See detailSolar Photocatalytic Destruction of p-Nitrophenol: A Pedagogical Use of Lab Wastes
Herrera-Melián, J. A.; Doña-Rodríguez, J. M.; Tello Rendón, E. et al

in Journal of Chemical Education (2001), 78(6), 775-777

In this article we propose the destruction of p-nitrophenol wastes obtained in a previous lab experiment, to generate a new lab experiment. The recommended destruction technique is solar TiO2 ... [more ▼]

In this article we propose the destruction of p-nitrophenol wastes obtained in a previous lab experiment, to generate a new lab experiment. The recommended destruction technique is solar TiO2-photocatalysis. When the effects of TiO2 and sunlight are tested separately, a slight decrease of p-nitrophenol is observed; but when TiO2 and sunlight are employed together p-nitrophenol disappears in 1 or 2 h. These experiments do not require sophisticated equipment or special lab training for the students. Groups of students tested different experimental conditions, such as the effect of different light intensities and sources (800-W UV-lamp, sunlight on sunny days, and sunlight on a cloudy day) or the addition of H2O2. p-Nitrophenol is degraded under the three light sources but at different rates. The addition of H2O2 to the TiO2-plus-sunlight system enhances p-nitrophenol degradation kinetics when compared with the TiO2 plus sunlight and H2O2 plus sunlight combinations. [less ▲]

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See detailComment j'explore ... la musculature paravertebrale lombaire dans les radiculopathies par electromyographie.
Tomasella, Marco ULg; Crielaard, Jean-Michel ULg; WANG, François-Charles ULg

in Revue Médicale de Liège (2001), 56(10), 716-22

Lumbar paraspinal muscles examination is an interesting part of the electrodiagnostic evaluation of patients with suspected lumbosacral radiculopathy. However, many electromyographers hesitate to ... [more ▼]

Lumbar paraspinal muscles examination is an interesting part of the electrodiagnostic evaluation of patients with suspected lumbosacral radiculopathy. However, many electromyographers hesitate to routinely include that technique in their study of lower limbs. The purpose of this paper is to specify the anatomy and electrophysiologic data of multifidus lumbar paraspinal muscle. Previous anatomic studies indicate that the medial lumbar multifidus and lumbar interspinalis muscles share unisegmental innervation by the dorsal ram of the spinal nerve. Electromyography of these muscles can improve the sensitivity of lumbosacral radiculopathy detection. Multi-MUP analysis of quantitative electromyographic parameters in lumbar paraspinal muscles, in a population of 75 healthy subjects without back pain, allowed to set up normal values for the L5 myotome. [less ▲]

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See detailThe Insulin-Sensitive Side of SHIP2
Schurmans, Stéphane ULg

in TheScientificWorldJournal (2001), 1

A substantial and increasing proportion of death and disability in the EU (and elsewhere) is attributable to diseases associated with insulin resistance (i.e., decreased insulin sensitivity). Beside type ... [more ▼]

A substantial and increasing proportion of death and disability in the EU (and elsewhere) is attributable to diseases associated with insulin resistance (i.e., decreased insulin sensitivity). Beside type II diabetes, other diseases like obesity, hypertension, atherosclerosis, hyperlipidaemia, polycystic ovarian syndrome, and acromegaly are indeed associated with insulin resistance [less ▲]

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See detailProfils de la progestérone des vaches zébu ‘Azawak’ et taurin ‘Gourunsi’ après induction de l’œstrus aux progestagènes combinés à la prostaglandine
Zongo, M.; Pitala, W.; Boly, H. et al

in Tropicultura (2001), 19(3), 131-134

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus ... [more ▼]

Un dosage radioimmunologique a été utilisé pour mesurer les concentrations de progestérone chez les zébus “Azawak” (Bos indicus, n = 6) et taurins Gourunsi (Bos taurus, n = 5) après induction de l'œstrus. Les observations ont été menées sur 11 vaches non gestantes (groupe I composé de 3 zébus Azawak et 3 taurins Gourunsi; groupe II composé de 3 zébus Azawak et 2 taurins Gourunsi), soumises à un traitement hormonal reposant sur l’administration d’un implant de progestagène, d’une injection de prostaglandine F2alpha et, pour une partie des femelles (groupe I), d’une injection de PMSG. Les implants ont été placés sous la peau de la face externe de l’oreille et maintenus pendant une période de 10 jours. Au 8e jour du traitement, les femelles ont reçu une injection intramusculaire de prostaglandine F2 (5 mg/100 kg) et au 10e jour, au moment du retrait, une injection de PMSG (400 UI/300 kg de poids vif) a été pratiquée sur les animaux du groupe I. Chez les taurins Gourunsi et chez les zébus Azawak ayant reçu l’injection de PMSG, le traitement a été suivi d’un œstrus dans 2 cas sur 3. Chez les animaux appartenant au groupe II, l’œstrus ne fut observé chez aucun taurin et seulement chez 1 des 3 zébus. Les concentrations de progestérone mesurées au cours des phases lutéales qui ont suivi sont restées faibles chez les taurins Gourunsi. Chez les zébus Azawak, les concentrations se sont révélées plus élévées chez les femelles ayant reçu l’injection de PMSG (6,0 +/- 1,2 ng/ml) que chez celles qui n’avaient pas reçu (3,2 +/- 0,8 ng/ml). [less ▲]

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See detailThe Uppermost Famennian around the world (Definition, biostratigraphical and sedimentological context)
Streel, Maurice ULg

in Newsletter. Subcommission on Devonian Stratigraphy (2001), 18

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See detailUtilisation des gènes à effet majeur en sélection laitière. Un exemple: le gène Pit-1
Renaville, Robert ULg; Parmentier, Isabelle; Fontaine, Sandrine et al

in Les Elevages belges (2001), 4

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See detailUne action intégrée en vue d'améliorer l'efficacité des systèmes d'enseignement : Le pilotage des systèmes d'enseignement
Demeuse, Marc ULg; Baye, Ariane ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (5-6), 23-50

Cet article s'inspire largement d'un chapitre du rapport non publié déposé en 1998 auprès de la Communauté européenne dans le cadre d'un projet entrepris grâce aux moyens accordés par l'action III.3.1 du ... [more ▼]

Cet article s'inspire largement d'un chapitre du rapport non publié déposé en 1998 auprès de la Communauté européenne dans le cadre d'un projet entrepris grâce aux moyens accordés par l'action III.3.1 du programme Socrates (Marc Demeuse) [less ▲]

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See detailDie endoluminale, kardiovaskuläre Radiotherapie:ein neuer Standard
Coucke, Philippe ULg; Ciernik, I-F

in Praxis (2001), 90

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of ... [more ▼]

The treatment for cardiovascular disease, especially the treatment of coronary stenosis, has been continously improving during the last decades. Routine use of angioplasty was improved by the use of coronary stenting further reducing cardiac morbidity. However, the incidence of restenosis after cardiovascular angioplasty remains high. The restenosis process is mainly explained by neo-intimal proliferation. Therefore, the utility of ionizing radiation has been systematically investigated in order to reduce proliferation of the neointimal tissue. Radiation therapy turns out to be a very efficient approach in reducing the rate of both de novo lesions as well as of instant restenosis. Recent clinical data from randomized trials confirm the utility of intracoronary radiation therapy and change the treatment standards in interventional cardiology. [less ▲]

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See detailHeat shock stimulation of a tilapia heat shock protein 70 promoter is mediated by a distal element
Molina, Alfredo; Di Martino, Emmanuel; Martial, Joseph ULg et al

in Biochemical Journal (2001), 356(Pt 2), 353-9

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell ... [more ▼]

We reported previously that a tilapia (Oreochromis mossambicus) heat shock protein 70 (HSP70) promoter is able to confer heat shock response on a reporter gene after transient expression both in cell culture and in microinjected zebrafish embryos. Here we present the first functional analysis of a fish HSP70 promoter, the tiHSP70 promoter. Using transient expression experiments in carp EPC (epithelioma papulosum cyprini) cells and in microinjected zebrafish embryos, we show that a distal heat shock response element (HSE1) at approx. -800 is predominantly responsible for the heat shock response of the tiHSP70 promoter. This element specifically binds an inducible transcription factor, most probably heat shock factor, and a constitutive factor. The constitutive complex is not observed with the non-functional, proximal HSE3 sequence, suggesting that both factors are required for the heat shock response mediated by HSE1. [less ▲]

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See detailObesite: aspects therapeutiques.
Scheen, André ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(10-12), 471-9480-2

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic ... [more ▼]

Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality. [less ▲]

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See detailVenlafaxine induced hair loss
PITCHOT, William ULg; ANSSEAU, Marc ULg

in American Journal of Psychiatry (The) (2001)

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See detailA simple clinical tool to identify Asian women with osteoporosis
Lou, SQ; Koh, L; Yang, BY et al

in Journal of Rheumatology (2001), 28(S63), 26

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See detailPrognostic value of decremental responses to repetitive nerve stimulation in ALS patients.
Wang, François-Charles ULg; De Pasqua, Victor ULg; Gerard, Pascale ULg et al

in Neurology (2001), 57(5), 897-9

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP ... [more ▼]

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year of riluzole therapy. The correlation between decrement and CMAP size reduction per year was highly significant (r = 0.77), but no relationship could be demonstrated between decrement and other variables. The authors thus propose that decrement after RNS may be used as a predictor of further drop in CMAP size. [less ▲]

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See detailStand der osteoporose-Therapie. Ein Medizinischer Skandal
Reginster, Jean-Yves ULg

in MMW Fortschritte der Medizin (2001), 143(14), 43

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See detailNumerical modelling of coupled transient phenomena
Charlier, Robert ULg; Radu, Jean-Pol ULg; Collin, Frédéric ULg

in Revue Française de Génie Civil (2001), 5(6), 719-743

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations ... [more ▼]

The basic phenomena involved in thermo-hydro-mechanical processes in geomaterials have been described in the 1st chapter. The equations describing these phenomena are non-linear differential equations. Their solution can generally only be approximated thanks to numerical methods. This is the main subject of the present chapter. First the type of problems and the set of equations to be solved will be shortly recalled. Emphasis will be given on the non-linear contributions. In a second section, the mostly developed numerical method, i.e. the finite difference and the finite element methods will be discussed under the light of the problems to be treated. The iterative techniques allowing the solution of non linear equations will be described. A third section will be dedicated to the coupling terms and to their modelling. The question that rises then is How to model efficiently problems, which may differ highly from, the point of view of the time and length scales? [less ▲]

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See detailEffects of 8-epi-Pgf2alpha on isolated bronchial smooth muscle of healthy and heaves-affected horses
Kirschvink, Nathalie; Art, Tatiana ULg; Lekeux, Pierre ULg et al

in Journal of Veterinary Pharmacology & Therapeutics (2001), 24(3), 215-221

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has ... [more ▼]

8-Epi-PGF2alpha, a prostaglandin-like compound generated by oxidative stress, has been shown to be an in vitro bronchoconstrictor in airways from healthy laboratory animals and healthy humans, but it has never been studied in diseased airways. Here, the bronchoconstrictive capacity of 8-epi-PGF2alpha on isolated bronchial rings (BR) of healthy and heaves-affected horses was evaluated by comparing the maximal effect and the potency of 8-epi-PGF2alpha to those of (1) acetylcholine (ACh), (2) its stereoisomer PGF2alpha and (3) its synthetic receptor agonist, U46619. Furthermore, the potential capacity of 8-epi-PGF2alpha to enhance the cholinergic (ACh) responsiveness of bronchial smooth muscle was investigated. 8-Epi-PGF2alpha contracted BR with a rank order of efficacy of Ach > U44619 > PGF2alpha > 8-epi-PGF2alpha in both healthy and heaves-affected horses. The contractile maximal response elicited by 8-epi-PGF2alpha was significantly smaller than that elicited by the other drugs, but was significantly higher in BR from heaves-affected horses than in those sampled in healthy horses, whilst pD2 values were similar. A subthreshold concentration of 8-epi-PGF2alpha (10-7 M) did not induce in vitro cholinergic hyper-responsiveness in BR of either healthy or heaves-affected horses. In conclusion, it has been demonstrated that 8-epi-PGF2alpha is an in vitro bronchoconstrictor of minor importance in healthy horses, but whose efficacy is significantly increased in heaves-affected horses. [less ▲]

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See detailLe kimbanguisme : un millénarisme dynamique de la terre aux Cieux
Melice, Anne ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (2001), 47 (suppl.)

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See detailThe Influence of Fetal and Postnatal Growth on Heart Rate Variability in Young Infants
Massin, M. M.; Withofs, Nadia ULg; Maeyns, K. et al

in Cardiology (2001), 95(2), 80-3

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in ... [more ▼]

Heart rate variability (HRV), a measure of cardiac autonomic control, was analyzed in infants to assess the hypothesis that early undernutrition may induce autonomic dysfunction that could play a role in the programming of later cardiovascular disease. HRV data were collected during a night session in 546 healthy infants at 5-12 weeks of adjusted age, and statistical associations with fetal and postnatal growth indices were established. A significant positive correlation between birth weight, the ratio of neonatal weight to head circumference and postnatal weight gain, and HRV indices mostly influenced by sympathetic activity was demonstrated in 11- and 12-week-old infants. A slight correlation (p > 0.05) was also found in younger infants. These data suggest the influence of fetal and postnatal growth on the programming of the autonomic nervous system beyond the neonatal period. This influence may be one of the important mechanisms that link impaired growth in fetal and infant life to high blood pressure and other cardiovascular disease during childhood and adulthood (the Barker hypothesis). [less ▲]

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See detailQuelle biodiversite pour nos lisieres forestieres?
Branquart, E.; Doucet, Jean-Louis ULg; Liesse, D. et al

in Parcs & Réserves (2001), 56(1), 26-32

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See detailLe XIXe siècle
Duchesne, Jean-Patrick ULg

in Art&fact (2001), 20

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See detailOn the exact solutions of the Lipkin-Meshkov-Glick model
Debergh, N.; Stancu, Floarea ULg

in Journal of Physics : A Mathematical & General (2001), A34

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within ... [more ▼]

We present the many-particle Hamiltonian model of Lipkin, Meshkov and Glick in the context of deformed polynomial algebras and show that its exact solutions can be easily and naturally obtained within this formalism. The Hamiltonian matrix of each $j$ multiplet can be split into two submatrices associated to two distinct irreps of the deformed algebra. Their invariant subspaces correspond to even and odd numbers of particle-hole excitations. [less ▲]

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See detailProper orthogonal decomposition for model updating of non-linear mechanical systems
Lenaerts, V.; Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Mechanical Systems & Signal Processing (2001), 15(1)

Proper orthogonal decomposition (POD), also known as Karhunen}Loeve (K}L) decomposition, is emerging as a useful experimental tool in dynamics and vibrations. The POD is a means of extracting spatial ... [more ▼]

Proper orthogonal decomposition (POD), also known as Karhunen}Loeve (K}L) decomposition, is emerging as a useful experimental tool in dynamics and vibrations. The POD is a means of extracting spatial information from a set of time-series data available on a domain. The use of (K}L) transform is of great help in non-linear settings where traditional linear techniques such as modal-testing and power-spectrum analyses cannot be applied. These decomposition can be used as an orthogonal basis for e$cient representation of the ensemble. The POM have been interpreted mainly as empirical system modes and the application of POD to measured displacements of a discrete structure with a known mass matrix leads to an estimation of the normal modes. We investigate the use of the proper orthogonal modes of displacements for the identi"cation of parameters of non-linear dynamical structures with an optimisation procedure based on the di!erence between the experimental and simulated POM. A numerical example of a beam with a local non-linear component will illustrate the method. (C) 2001 Academic Press [less ▲]

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