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See detailAvantages des nouveaux traitements contre les puces et les tiques
Delaunois, A.; Gustin, Pascal ULg

in Pharma-Sphère (1999), 30

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See detailNegative magnetoresistance in mixed-valence La0.6Y0.1Ca0.3MnO3: Evidence for charge localization governed by the Curie-Weiss law
Sergeenkov, S.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 70(2), 141-146

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss ... [more ▼]

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss-dominated transport mechanism in this material both above and below the field-dependent Curie temperature T(C)equivalent to T-0. Attributing this symmetry to strong magnetic fluctuations below T-C (which are triggered by the Y substitution and cause a "bootstrap" destruction of the ferromagnetic phase), the data are interpreted in terms of the nonthermal spin hopping and magnetization-dependent charge carrier localization scenario leading to Delta rho=-rho(s)(1-e(-gamma M2)), with the magnetization M(T,B)=CB/\ T-T-C(B)\(nu). The separate fits through all the data points above and below T-C yield C(+)similar or equal to 2C(-) and nu(+)similar or equal to nu(-)similar or equal to 1, in agreement with the predictions of the Landau mean-field theory. (C) 1999 American Institute of Physics. [S0021-3640(99)01314-6]. [less ▲]

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See detailRecurrent abortion. Etiology and occurrence
VAN LINTHOUT, Christine ULg; Ahrendt, J.

in Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg (1999), (2), 59-71

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See detailPronostic Implications of semi-supine stress echocardiography for evaluation of chest pain in the emergency room
LANCELLOTTI, Patrizio ULg; HOFFER, E; APPELTANS, H et al

in European Journal of Echocardiography (1999)

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See detailDiagnosis of myxomatosis by an indirect immunoperoxidase test
Marlier, Didier ULg; Boucraut-baralon, Corine; Vindevogel, Henri ULg

in Vlaams Diergeneeskundig Tijdschrift (1999), 68

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See detailAn Optimization Method for the Design of Physical and Maxwellian Absorbers
Meys, B.; Henrotte, F.; Geuzaine, Christophe ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1430--1433

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See detailLa formation de formateurs en Communauté française de Belgique
Beckers, Jacqueline ULg

in Puzzle (1999), 6(juin), 21-22

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See detailPreparation of low-density xerogels through additives to TEOS-based alcogels
Alié, Christelle ULg; Pirard, René ULg; Lecloux, A. J. et al

in Journal of Non-Crystalline Solids (1999), 246(3), 216-228

A new process for preparing silica xerogels with similar textural properties to silica aerogels by drying under vacuum has been studied. The xerogels are produced by adding, before gelation, 3-(2 ... [more ▼]

A new process for preparing silica xerogels with similar textural properties to silica aerogels by drying under vacuum has been studied. The xerogels are produced by adding, before gelation, 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) to tetraethylorthosilicate (TEOS)-based alcogels, synthesised in a single base-catalysed (NH3) step. It is hypothesized that EDAS acts as a nucleation agent leading to silica particles with a hydrolysed EDAS core and a shell principally made of hydrolysed TEOS. The EDAS concentration and the basicity of the aqueous NH3 solution are important parameters influencing the resistance of the gel to drying stress. A decreasing EDAS/TEOS ratio or an increasing concentration of NH3 at constant EDAS content leads to less shrinkage during drying and so the final pore volume is larger. Gels prepared with a low EDAS/TEOS ratio (about 0.03) contain large particles (similar to 20 nm) due to the nucleation process by EDAS, thus the pores between those particles are also large and the drying stress is reduced. (C) 1999 Published by Elsevier Science B.V. All rights reserved. [less ▲]

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See detailCytokinin modulates catalase activity and coumarin accumulation in in vitro cultures of tobacco
Petit-Paly, Geneviève; Franck, Thierry ULg; Brisson, Louise et al

in Journal of Plant Physiology (1999), 155(1), 9-15

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present ... [more ▼]

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present work, we demonstrate the effect of CKs on catalase activity in tobacco cultivated in vitro. The catalase activity observed in suspension-cultured cells decreased slightly during the first hour of CK treatment and increased thereafter to double the level detected in untreated cells. In contrast to these results, catalase activity was inhibited in shoot cultures in which the endogenous levels of CK were elevated by the introduction of the isopentenyltransferase gene or by an exogenous feeding of CK to the cultures. Interestingly, this catalase inhibition correlated with an accumulation of scopolin, an inducible coumarin. Taken together, our results show that CK modulates (directly or undirectly) catalase activity. The inverse relationship that was always found between scopolin accumulation and catalase activity is discussed in terms of vitrification and habituation. [less ▲]

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See detailA comparative study of the hydrophyte flora from the Alpine Rhine to the Middle Rhine. Application to the conservation of the Upper Rhine aquatic ecosystems
Vanderpoorten, Alain ULg; Klein, J. P.

in Biological Conservation (1999), 87(2), 163-172

A typology of the main channel of the river Rhine according to its aquatic bryophyte and vascular hydrophyte assemblages is presented. The aquatic bryophytes are especially abundant in the main channel ... [more ▼]

A typology of the main channel of the river Rhine according to its aquatic bryophyte and vascular hydrophyte assemblages is presented. The aquatic bryophytes are especially abundant in the main channel, having found stable, rocky habitats with variable water levels in the regulated river, and segregate longitudinally along a gradient of water quality. Conversely, the vascular hydrophytes are restricted to side channels with constant discharges and silt deposits, and segregate laterally along a gradient of connectivity with the main river. The hydrophytes have been affected by water eutrophication which became obvious in the 1960s-1970s. The oligotrophic groundwater-fed side-channels disconnected since the river canalization consequently include a relic reference flora. Important hydraulic works are currently in progress in order to protect the areas located downstream from the canalized Rhine from flooding by retaining the river waters in lateral systems during the discharge peaks and to recreate a functional alluvial floodplain by reconnecting the disconnected side-channels to the main river. The floodpulse caused by the suddent input of surface water in the disconnected brooks will probably wash out most of the hydrophytes and it is very likely that the rare species with their low recolonization strategies will disappear in these conditions. It is highly desirable to preserve from flooding the last oligotrophic brooks with their original hydrophyte assemblages. Those brooks which show a tendency to silt up can be re-dynamized by ecological engineering without disturbing the flowing drains of the watertable. In areas (including flowing drains of the watertable) that have already been designated for flood retention, the hydraulic works should allow, as far as possible, the preservation of the flowing oligotrophy streams by only permitting the input of surface water in the silted-up brooks. The disconnected side-channels could then continue their role as refugia from where the main channel, whose water quality has been improving for a decade, could be recolonized by its primary flora. [less ▲]

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See detailFirst-principles characterization of the four phases of barium titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1999), 220(1-2), 1-15

Using a first-principles approach, the four phases of perovskite barium titanate are studied. We determine the lattice parameter, the bulk modulus and the cohesive energy of the cubic phase; the relaxed ... [more ▼]

Using a first-principles approach, the four phases of perovskite barium titanate are studied. We determine the lattice parameter, the bulk modulus and the cohesive energy of the cubic phase; the relaxed atomic positions in the three ferroelectric structures; and the evolution of the electronic properties from one phase to the other. The role of electronic exchange-correlation energy in the stabilization of the different phases is also investigated. [less ▲]

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See detailCathepsin L in eggs and larvae of perch Perca fluviatilis: variations with developpement stage and spawning
Kestemont, Patrick; Cooremens, J.; Abi-Ayad, A. et al

in Fish Physiology and Biochemistry (1999), 21

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See detailLe trésor des reliques de l'abbaye Saint-Hubert en Ardenne
George, Philippe ULg

in Études & Documents de la Région Wallonne. Monuments & Sites (1999)

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See detailLa greffe de cellules souches hematopoietiques dans la drepanocytose.
Cornu, G.; Vermylen, C.; Ferster, Aline et al

in Archives de Pédiatrie (1999), 6 Suppl 2

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See detailContribution of the carbohydrate moiety to conformational stability of the carboxypeptidase Y high pressure study.
Dumoulin, Mireille ULg; Ueno, H.; Hayashi, R. et al

in European Journal of Biochemistry (1999), 262(2), 475-83

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the ... [more ▼]

The process of pressure-induced denaturation of carboxypeptidase Y and the role of the carbohydrate moiety in its response to pressure and low temperature were investigated by measuring in situ the catalytic activity and, the intrinsic and 8-anilino-1-naphthalene sulfonic acid binding fluorescences. Pressure-induced denaturation of carboxypeptidase Y is a process involving at least three transitions. Low pressures (below 150 MPa) induced slight conformational changes characterized by a slight decrease in the center of the spectral mass of intrinsic fluorescence, whereas no changes in 8-anilino-1-naphthalene sulfonic acid binding fluorescence were observed and 80% of the catalytic activity remained. Higher pressure (150-500 MPa) induced further conformational changes, characterized by a large decrease in the center of the spectral mass of intrinsic fluorescence, a large increase in the 8-anilino-1-naphthalene sulfonic acid binding fluorescence and the loss of all catalytic activity. Thus, this intermediate exhibited characteristics of molten globule-like state. A further increase, in pressure (above 550 MPa) induced transition from this first molten globule-like state to a second molten globule-like state. This two-stage denaturation process can be explained by assuming the existence of two independent structural domains in the carboxypeptidase molecule. A similar three-transition process was found for unglycosylated carboxypeptidase Y, but, the first two transitions clearly occurred at lower pressures than those for glycosylated carboxypeptidase Y. These findings indicate that the carbohydrate moiety protects carboxypeptidase Y against pressure-induced denaturation. The origin of the protective effects is discussed based on the known crystallographic structure of CPY. [less ▲]

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See detailGerhard Herzberg (1904-1999)
Biémont, Emile ULg; Dubois, I.

in Annuaire Cl. Sc. Acad. Roy. (1999), X

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See detailConversion of green note aldehydes into alcohols by yeast alcohol dehydrogenase
Fauconnier, Marie-Laure ULg; Mpambara, A.; Delcarte, Jérôme et al

in Biotechnology Letters (1999), 21(7), 629-633

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into ... [more ▼]

‘Green note’ aldehydes were successfully reduced into their corresponding alcohol by commercial yeast alcohol dehydrogenase. Among different yeasts tested for their ability to convert (Z)-3-hexenal into (Z)-3-hexenol, Pichia anomala gave the best results. Conversion yields higher than 90% were also obtained by directly conducting the reaction in the medium where (Z)-3-hexenal is produced by the action of lipoxygenase and hydroperoxide lyase on <br />linolenic acid. [less ▲]

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See detailLicéité des baux au regard de la police de l'aménagement du territoire et de l'urbanisme
Delnoy, Michel ULg

in Actualités Juridiques des Baux (1999)

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See detailIntervention sur quelques aspects économiques de la réforme
Jurion, Bernard ULg

in Revue de la Faculté de Droit de l'Université de Liège (1999)

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See detailImmunocytochemistry of lipids : chemical fixatives have dramatic effects on the preservation of tissue lipids
Maneta-Peyret, Lilly; Compère, Philippe ULg; Moreau, Patrick et al

in Histochemical Journal (The) (1999), 31

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See detailHypo- et hypertension intracrânienne bénigne
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Revue Médicale de Liège (1999), 54(8), 671-676

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See detailUnimolecular Dynamics from Kinetic Energy Release Distributions. V. How does the Efficiency of Phase Space Sampling vary with Internal Energy?
Hoxha, A.; Locht, Robert ULg; Lorquet, Andrée ULg et al

in Journal of Chemical Physics (1999), 111(20), 9259-9266

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the ... [more ▼]

A retarding field technique coupled with a quadrupole mass analyzer has been used to obtain the kinetic energy release distributions (KERDs) for C2H3Br+->[C2H3]++Br dissociation as a function of the internal energy. The KERDs obtained by dissociative photoionization using the He(I), Ne(I) and Ar(II) resonance lines were analyzed by the maximum entropy method and were found to be well described by introducing a single dynamical constraint, namely the relative translational momentum of the fragments. Ab initio calculations reveal the highly fluxional character of the C2H3+ ion. As the energy increases, several vibrational modes are converted in turn into large-amplitude motions. Our main result is that, upon increasing internal energy, the fraction of phase space sampled by the pair of dissociating fragments is shown to first decrease, pass through a shallow minimum around 75%, and then increase again, reaching almost 100% at high internal energies (8 eV). This behaviour at high internal energies is interpreted as resulting from the conjugated effect of intramolecular vibrational redistribution (IVR) and radiationless transitions among potential energy surfaces. Our findings are consistent with the coincidence data of Miller and Bear, reanalyzed here, and with the KERD of the metastable dissociation. [less ▲]

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See detailLe point de vue de l'économiste
Jurion, Bernard ULg

in La nouvelle procédure fiscale, Commision Université-Palais (1999), XXX(II), 99-108

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See detailPharma-clinics le medicament du mois. L'orlistat (xenical).
Scheen, André ULg; Ernest, Philippe ULg; Letiexhe, Michel ULg

in Revue Médicale de Liège (1999), 54(3), 192-6

Orlistat (tetrahydrolipstatin), launched by Roche under the trade name Xenical, is a selective inhibitor of pancreatic and gastro-intestinal lipases. It reduces the digestion of dietary fat and its ... [more ▼]

Orlistat (tetrahydrolipstatin), launched by Roche under the trade name Xenical, is a selective inhibitor of pancreatic and gastro-intestinal lipases. It reduces the digestion of dietary fat and its resorption through digestive mucosa by around 30%. It is indicated, at a dose of 3 x 120 mg/day (one dose with each meal) and together with a moderately low-calorie and low-fat diet, for the treatment of obesity. It has been shown, in placebo-controlled two-year trials, to almost double the number of obese subjects who succeed in loosing at least 10% of initial body weight. Independently, it contributes to decrease serum cholesterol levels by 6-10%. Because of its mechanism of action, this drug can induce intestinal side-effects which tend to decrease with time and with the reduction of fat intake, thus improving diet compliance. [less ▲]

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See detailPit-1 mediates cell-specific and cAMP-induced transcription of the tilapia GH gene
Sekkali, B.; Belayew, A.; Bortolussi, M. et al

in Molecular & Cellular Endocrinology (1999), 152(1-2), 111-23

Expression of the tilapia growth hormone (tiGH) gene is pituitary-specific and controlled by intracellular cAMP levels. DNaseI protection experiments allowed us to identify four Pit-1 binding sites in the ... [more ▼]

Expression of the tilapia growth hormone (tiGH) gene is pituitary-specific and controlled by intracellular cAMP levels. DNaseI protection experiments allowed us to identify four Pit-1 binding sites in the tiGH - 465/ + 19 region. Deletion and mutagenesis analysis revealed that the - 131/+ 19 region, containing two Pit-1 sites, or four copies of the most proximal site tiGHF1 fused to the heterologous Tk promoter, confer high level expression in rat pituitary cells and direct transcription in non-pituitary cells only after expression of rat Pit-1. We show that a tilapia pituitary factor specifically binds to site tiGHF1 and obtained a partial cDNA sequence coding for tilapia Pit-1. The cAMP stimulation is mediated by the proximal (- 131/- 31) promoter region. It is Pit-1-dependent and requires the tiGHF1 site. In addition, four copies of this site confer cAMP inducibility to the Tk promoter in GC cells. [less ▲]

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See detailHuman Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
Colige, Alain ULg; Sieron, A. L.; Li, S. W. et al

in American Journal of Human Genetics (1999), 65(2), 308-17

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia ... [more ▼]

Ehlers-Danlos syndrome (EDS) type VIIC is a recessively inherited connective-tissue disorder, characterized by extreme skin fragility, characteristic facies, joint laxity, droopy skin, umbilical hernia, and blue sclera. Like the animal model dermatosparaxis, EDS type VIIC results from the absence of activity of procollagen I N-proteinase (pNPI), the enzyme that excises the N-propeptide of type I and type II procollagens. The pNPI enzyme is a metalloproteinase containing properdin repeats and a cysteine-rich domain with similarities to the disintegrin domain of reprolysins. We used bovine cDNA to isolate human pNPI. The human enzyme exists in two forms: a long version similar to the bovine enzyme and a short version that contains the Zn++-binding catalytic site but lacks the entire C-terminal domain in which the properdin repeats are located. We have identified the mutations that cause EDS type VIIC in the six known affected human individuals and also in one strain of dermatosparactic calf. Five of the individuals with EDS type VIIC were homozygous for a C-->T transition that results in a premature termination codon, Q225X. Four of these five patients were homozygous at three downstream polymorphic sites. The sixth patient was homozygous for a different transition that results in a premature termination codon, W795X. In the dermatosparactic calf, the mutation is a 17-bp deletion that changes the reading frame of the message. These data provide direct evidence that EDS type VIIC and dermatosparaxis result from mutations in the pNPI gene. [less ▲]

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See detailPurification of active matrix metalloproteinase catalytic domains and its use for screening of specific stromelysin-3 inhibitors.
Kannan, R.; Ruff, M.; Kochins, J. G. et al

in Protein Expression & Purification (1999), 16

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 ... [more ▼]

The matrix metalloproteinase (MMP) stromelysin-3 (ST3) has been shown to be involved in malignant tumor progression and therefore represents an attractive therapeutical target. In order to screen for ST3 synthetic inhibitors, we have produced and purified the catalytic domain of ST3, matrilysin, stromelysin-2, and membrane type-1 MMP from inclusion bodies in a bacterial system. Our strategy allowed the purification of MMPs directly in the active form, thereby avoidingin vitroactivation. A total of 140,000 synthetic compounds from the Bristol-Myers Pharmaceutical Research Institute chemical deck were tested, using a substrate-based colorimetric enzymatic assay, in which ST3 activity was evaluated through its ability to cleave and inactivate α-1 proteinase inhibitor. One ST3 inhibitor belonging to the cephalosporin family of antibiotics was thereby identified. [less ▲]

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See detailRadiative Properties of Neutral Germanium obtained from excited-state lifetime and branching-ratio measurements and comparison with theoretial calculations
Li, Z. S.; Norin, J.; Persson, A. et al

in Physical Review. A (1999), 60

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See detailTreatment of osteoporosis : where are we and where are we going to
Reginster, Jean-Yves ULg

in Morphologie : Bulletin de l'Association des Anatomistes (1999), 83(261), 41-5

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to ... [more ▼]

In the past years, there has been a multiplication of drugs identified as candidates for use in the prevention or the treatment of osteoporosis. When treating established osteoporosis, the objective is to prevent further skeletal deterioration, improve bone mass and/or bone microarchitecture to provide a documented reduction of the risk of vertebral and/or peripheral fractures. Calcium and vitamin D have been shown to be particularly efficient in elderly patients, mainly to prevent non-vertebral fractures. By inhibiting osteoclastic activity, calcitonin improves bone mineral density at all sites. Preliminary results suggest that it might also decrease vertebral fracture rates. Bisphosphonates have been investigated for 20 years in the treatment of osteoporosis. Alendronate was shown to reduce spinal and extravertebral fractures. New formulations of fluoride, like monofluorophosphate appear to be particularly beneficial in women with mild to moderate osteoporosis. Several new compounds, including parathormone, strontium salts, ipriflavone or others are currently developed and subject to large investigational programs to demonstrate their ability to reduce fracture. [less ▲]

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See detailCharacterization of YKL165c a new essential gene of the yeast Saccharomyces cerevisiae.
Delbecq, X.; Godrie, Thérèse ULg; Portetelle, Daniel ULg et al

in Current Genetics (1999), 35

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See detailThe crustal tongue melting model and the origin of massive anorthosites
Duchesne, Jean-Clair ULg; Liégeois, Jean-Paul ULg; Vander Auwera, Jacqueline ULg et al

in Terra Nova (1999), 11

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels ... [more ▼]

Recent detailed field studies in several anorthosite complexes have shown that anorthosites are frequently linked with weakness zones in the crust which favour their emplacement at mid-crust levels. Recent experimental data have also shown that the parent magma compositions of various anorthosite massifs lie on thermal highs in the relevant phase diagrams, indicating that these magmas cannot be derived by fractionation of peridotitic mantle melts but rather are produced by melting of gabbronoritic sources. In the Sveconorwegian province terrane boundaries have been traced in deep seismic profiles to Moho offsets or to tongues of lower crustal material underthrust to depths of 40-50 km. We therefore suggest that the parent magmas of anorthosite massifs are produced by melting of gabbronoritic rocks from the lower crust that had been thrust into the mantle by collision of terranes. [less ▲]

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See detailThe Practice of European Union Citizenship
Martiniello, Marco ULg

in Research Perspectives on Migration (1999), 2(2), 16-18

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See detailLa gestion forestière durable en Région wallonne : L'apport de l'inventaire permanent - Partie 2 : Intégration des indicateurs à l'inventaire
Lecomte, Hugues; Koestel, G.; Rondeux, Jacques ULg

in Silva Belgica (1999), 106(2), 7-14

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau ... [more ▼]

Dans une étude récente KOESTEL et al. [1999], après avoir rappelé les différents critères et indicateurs de gestion forestière durable adoptés à l'échelle internationale, montrent comment, au niveau régional, un inventaire forestier permanent peut, outre les variables et paramètres qu'il traite habituellement, prendre en charge ces indicateurs. Moyennant quelques ajustements méthodologiques, il s'est avéré dans le cas de la Région wallonne, que l'Inventaire des Ressources ligneuses pouvait, grâce aux techniques d'échantillonnage qu'il met en oeuvre, constituer un outil pertinent pour dresser un état des lieux du développement durable en milieu forestier. En outre, du fait de son caractère permanent, il permet d'assurer le suivi de l'évolution des critères et indicateurs au cours du temps. Nous rappellerons très brièvement les bases méthodologiques de l'inventaire forestier régional (paragraphe 2) et les résultats de l'étude qui était destinée à lui faire prendre en compte des indicateurs de gestion durable (paragraphe 3). Nous nous attacherons à montrer comment ces indicateurs sont concrètement, selon les cas, observés, mesurés, calculés et traités (paragraphe 4), puis nous tirerons les quelques conclusions qui paraissent s'imposer (paragraphe 5). [less ▲]

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See detailSerological and Biochemical Follow-up in Cattle Naturally Infected with Fasciola Hepatica, and Comparison with a Climate Model for Predicting Risks of Fasciolosis
Bossaert, K.; Lonneux, J. F.; Godeau, Jean-Marie ULg et al

in Veterinary Research (1999), 30(6, Nov-Dec), 615-28

Several biological parameters were measured in 31 heifers naturally infected with Fasciola hepatica during one grazing season in the Belgian Ardennes. A forecast model based on daily temperature used to ... [more ▼]

Several biological parameters were measured in 31 heifers naturally infected with Fasciola hepatica during one grazing season in the Belgian Ardennes. A forecast model based on daily temperature used to assess the risk of fasciolosis was fitted to this assay. Cattle were turned out to two pastures. Each pasture was divided into two plots: one was treated with calcium cyanamide and the other was left untreated. The Lymnaea truncatula snails were counted on three different occasions. The results indicated a poor molluscicide efficiency. Body weight gains, anti-Fasciola antibody levels, faecal egg counts, levels of sorbitol dehydrogenase (SDH) and gamma-glutamyl transferase (gamma GT), packed cell volumes, white blood cells and differential leucocyte counts were determined monthly. No statistically significant difference was observed between animals from the two plots regardless of the recorded data. No correlation was found between body weight gains and other biological data. The sampling date had a significant effect on the antibody responses within a same group, and on the enzymatic levels for all groups combined. The forecast results were consistent with the recorded data. Temperature was a major bioclimatic constraint on the transmission of life cycle, and risk of infection occurred mainly in late spring (May/June) and in early September. Current results might be used to issue advice on the need for flukicide treatment of cattle. The indicators of the infection considered alone were useless and it is concluded that herd diagnosis of fasciolosis may rely on the rise of specific antibody levels, possibly associated with an increase in hepatic enzyme activities. [less ▲]

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See detailLocalization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis
Jacquemin, Patrick; Depetris, Danielle; Mattei, Marie-Geneviève et al

in Genomics (1999), 55(1), 127-9

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and ... [more ▼]

Embryonic TEA domain-containing factor (ETF) belongs to the family of proteins structurally related to transcriptional enhancer factor-1 (TEF-1) and is implicated in neural development. Isolation and characterization of the cosmid clones encoding the mouse ETF gene (Etdf) revealed thatEtdfspans approximately 17.9 kb and consists of 12 exons. The exon–intron structure ofEtdfclosely resembles that of theDrosophila scallopedgene, indicating that these genes may have evolved from a common ancestor. The multiple transcription initiation sites revealed by S1 protection and primer extension analyses are consistent with the absence of the canonical TATA and CAAT boxes in the 5′-flanking region, which contains many potential regulatory sequences, such as the E-box, N-box, Sp1 element, GATA-1 element, TAATGARAT element, and B2 short interspersed element (SINE) as well as several direct and inverted repeat sequences. TheEtdflocus was assigned to the proximal region of mouse chromosome 7 using fluorescencein situhybridization and linkage mapping analyses. These results provide the molecular basis for studying the regulation,in vivofunction, and evolution ofEtdf. *1 The approved gene symbol for embryonic TEA domain-containing factor (ETF) by MGD isEtdf.The nucleotide sequences reported in this paper have been deposited with the GenBank/EMBL/DDBJ Data Libraries under Accession Nos. D83586–D83596. Mapping data from this article have been deposited in the Mouse Genome Database under Accession Nos. MGD-CREX-618 for genetic mapping and MGD-INEX-21 forin situhybridization, respectively. [less ▲]

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See detailEncurvadura Lateral de Vigas Metalicas Sujeitas à Acçao do Fogo - Estudo Numerico e Experimental
Vila Real, Paulo; Piloto, Paulo; Franssen, Jean-Marc ULg et al

in Mecânica Experimental (1999), 4

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See detailHypo- et hypertension intracrâniennes bénignes
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Ahead in neurology (1999), 3(1), 10-15

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See detailThe plant alkaloid usambarensine intercalates into DNA and induces apoptosis in human HL60 leukemia cells
Dassonneville, L.; Wattez, N.; Mahieu, C. et al

in Anticancer Research (1999), 19(6B), 5245-5250

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See detailTibère et l'astrologie (Suétone, Vie de Tibère, 36 et 69)
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailExperimental and theoretical radiative lifetimes, branching fractions and oscillator strengths in Lu II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Monthly Notices of the Royal Astronomical Society (1999), 307

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See detailInvariant bidifferential operators on tensor densities over a contact manifold
Mathonet, Pierre ULg

in Letters in Mathematical Physics (1999), 48(3), 251-261

The spaces of tensor densities over a manifold M are modules over the Lie algebra Vect (M) of vector fields over the manifold. When M is a contact manifold, one can consider the algebra C(M) of vector ... [more ▼]

The spaces of tensor densities over a manifold M are modules over the Lie algebra Vect (M) of vector fields over the manifold. When M is a contact manifold, one can consider the algebra C(M) of vector fields which preserves the contact structure. If the manifold is endowed with a contact projective structure, there is an embedding of the linear symplectic algebra sp (2n+2,R) in C(M). In this Letter, we determine the C(M)- and the sp(2n+2,R)-invariant bidifferential operators on tensor densities. [less ▲]

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See detailClinical use of a bioartificial liver to treat acetaminophen-induced fulminant hepatic failure
Detry, Olivier ULg; Arkadopoulos, N.; Kahaku, E. et al

in American Surgeon (1999), 65

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See detailViaticum = facultas
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1999), 58

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See detailAnalyse préliminaire de la situation et des perspectives de la culture du haricot de Lima (Phaseolus lunatus L.) sur la Côte péruvienne (Vallées d'Ica, Pisco et Casma).
Rouschop, P.; Baudoin, Jean-Pierre ULg; Mayta, F. C. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(2), 115-126

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See detailA Namurian A (Silesian) permineralised flora from the "Carrière du Lion" at Engihoul (Belgium).
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Galtier, Jean

in Review of Palaeobotany and Palynology (1999), 107

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See detailHas disinfection of endoscopes by automatic machines become obligatory?
Delwaide, Jean ULg; Pelckmans, P.; Defrance, P. et al

in Revue Médicale de Bruxelles (1999), 20(1), 49-50

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See detailCapital humain, emploi et revenus du travail: Belgique, 1992
Docquier, Frédéric; Laurent, Sébastien; Perelman, Sergio ULg

in Cahiers Economiques de Bruxelles (1999), (161), 77-103

L’objet de ce papier est de mettre en évidence, pour un échantillon de travailleurs salariés masculins, le rôle de l’éducation et, de façon plus large, du capital humain sur l’emploi et la formation des ... [more ▼]

L’objet de ce papier est de mettre en évidence, pour un échantillon de travailleurs salariés masculins, le rôle de l’éducation et, de façon plus large, du capital humain sur l’emploi et la formation des salaires en Belgique. A partir de données individuelles, on estime économétriquement les relations entre d’une part, le diplôme obtenu et, d’autre part, le fait d’avoir un emploi ainsi que le niveau de rémunération correspondant. Les résultats obtenus confirment de manière statistiquement significative ces relations en mettant en évidence non seulement le rôle du niveau des études mais également celui du type d’enseignement (général, technique, professionnel) poursuivie sur le rendement en capital humain. On montre aussi que la dimension régionale a une importance non négligeable sur le taux d’occupation; par contre, elle s’avère être totalement inopérante sur la formation des salaires. [less ▲]

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See detailSeparation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes.
Fillet, Marianne ULg; Bechet, Isabelle; Piette, Véronique et al

in Electrophoresis (1999), 20(9), 1907-15

The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen ... [more ▼]

The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen, suprofen, ketoprofen, naproxen, indomethacin, carprofen, indoprofen, sulindac) in capillary electrophoresis (CE) using completely nonaqueous systems. The influence of different parameters such as nature and proportion of organic solvent (methanol, acetonitrile, 2-propanol), apparent pH (ranging from 7 to 9) and temperature (ranging from 25 to 40 degrees C) on selectivity and migration times were studied systematically in an uncoated fused-silica capillary. A nonaqueous electrolyte made of 50 mM ammonium acetate - 13.75 mM ammonia in methanol proved to resolve 11 NSAIDs at 25 degrees C and 13 NSAIDs at 36 degrees C, both within 13 min and without a modifier besides the methanol itself. The same buffer containing 30% acetonitrile provides a satisfactory separation for 13 NSAIDs within 14 min at 25 degrees C. [less ▲]

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See detailAn MRI study of the effect of treadmill training on bone morphology of the central and third tarsal bones of young Thoroughbred horses
Whitton, R. C.; Murray, R. C.; Buckley, C. et al

in Equine Veterinary Journal. Supplement (1999), 30

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to ... [more ▼]

Training results in marked modelling of the subchondral bone of the carpus, but the effect of training on the subchondral bone of the distal tarsal joints is unknown. The aim of this study was to determine whether training influenced modelling of the third and central tarsal bones in Thoroughbred horses. Twelve untrained Thoroughbred horses were divided into 2 groups. Group 1 underwent a 19 week progressive training regimen on a high speed treadmill. Group 2 were walked for 40 min daily. Images of left tarsi were obtained by magnetic resonance imaging (MRI) with a 0.5 Tesla superconducting magnet using a spin echo sequence. Sagittal and oblique sagittal slices were made perpendicular to the articular surfaces of the intertarsal joints and were analysed using image analysis software to measure the proportion of dense subchondral bone in the dorsal facet of each bone. Mean +/- s.d. percentage area of dense subchondral bone in the dorsal facet of the central tarsal bone in Group 1 was 47 +/- 8 medially, 46 +/- 4 sagitally and 50 +/- 11 dorsolaterally, whereas in Group 2 it was 39 +/- 16 medially, 43 +/- 8 sagitally and 53 +/- 7 dorsolaterally. For the third tarsal bone mean +/- s.d. percentage area of dense subchondral bone in Group 1 was 32 +/- 10 medially, 39 +/- 11 sagitally and 44 +/- 8 dorsolaterally, whereas in Group 2 it was 28 +/- 8 medially, 37 +/- 6 sagitally and 41 +/- 9 dorsolaterally. There was no significant difference in percentage area of dense subchondral bone between the trained and untrained horses. An effect of treadmill training of Thoroughbred horses on modelling of the central and third tarsal bones could not be demonstrated. [less ▲]

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See detailLe langage à l'envers
Steinmetz, Rudy ULg

in Louvain : Revue Mensuelle de l'Université Catholique de Louvain et de l'Association des Anciens et Amis de l'UCL (1999)

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See detailAt the center, what?’ Giacomo Joyce, Roland Barthes and the Novelistic Fragment
Delville, Michel ULg

in James Joyce Quarterly (1999), 36(4), 765-780

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See detailCharacterizations by automorphism groups of some rank 3 buildings, III. Moufang-like conditions
Van Steen, Kristel ULg

in Geometriae Dedicata (1999), 74(3), 225-240

In this paper, we introduce the root-Moufang condition and the p-adic Moufang condition. We show that affine buildings of type (A) over tilde(2) satisfying the root-Moufang condition are Bruhat-Tits ... [more ▼]

In this paper, we introduce the root-Moufang condition and the p-adic Moufang condition. We show that affine buildings of type (A) over tilde(2) satisfying the root-Moufang condition are Bruhat-Tits buildings. Also, every rank 3 affine building satisfying the p-adic Moufang condition is a Bruhat-Tits building. We motivate the introduction of the new conditions by showing that all Bruhat-Tits (A) over tilde(2)-buildings satisfy the root-Moufang condition, and that the (A) over tilde(2)-buildings over a p-adic field also satisfy the p-adic Moufang condition. Another application of the p-adic Moufang condition is given in Part IV of this paper. [less ▲]

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See detailCalcul et conception économique des assemblages de profilés reconstitués soudés
Braham, M.; Cerfontaine, F.; Jaspart, Jean-Pierre ULg

in Construction Métallique (1999), (N°1), 5-24

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See detailClinical Activity and Benefit of Irinotecan (CPT-11) in Patients with Colorectal Cancer Truly Resistant to 5-Fluorouracil (5-FU)
Van Cutsem, Eric; Cunningham, D.; Ten Bokkel Huinink, W. W. et al

in European Journal of Cancer (1999), 35

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See detailUne justice pénale européenne après Amsterdam
Flore, Daniel ULg

in Journal des Tribunaux Droit Européen (1999)

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See detailExploration isocinétique : analyse des courbes
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg

in Annales de Réadaptation et de Médecine Physique (1999), 42

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé ... [more ▼]

Introducition: La courbe isocinétique met en relation le moment de force développé et le positionnement articulaire: elle autorise l'étude in vivo de la relation classique tension-longueur. Le tracé isocinétique se caractérise occasionnellement par un profil anormal. Méthode: Sur la base de l'expérience clinique, les auteurs proposent une classification d'anomalies; plusieurs facteurs contribuent à leur apparition: une collaboration ou une familiarisation insuffisante du patient, un protocole inadéquat, une amyotrophie majeure, une modification de la biomécanique articulaire, des troubles neurologiques ainsi que des phénomènes algiques au cours de l'exercice. Discussion et conclusion: L'intérêt diagnostique des courbes isocinétiques ne semble pas crédible, comme l'indique une étude centrée sur la nature et la fréquence des anomalies dans différents groupes de lésions opérées ou non opérées du ligament croisé antérieur. Sous réserve d'une analyse rigoureuse, les implications rééducatives paraissent néanmoins intéressantes lorsqu'une anomalie reproductible de la courbe s'accompagne d'un phénomène algique. [less ▲]

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See detailLes formes et les titulaires de la faculté prévue par l'article 1421 du Code judiciaire
Boularbah, Hakim ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (1999)

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See detailEthnic Mobilisation and political participation in Europe
Martiniello, Marco ULg; Statham, P.

in Journal of Ethnic and Migration Studies (1999), 25(4),

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See detailEvolution of organic debris and palynomorph preservation in two late middle Frasnian sections, southern Dinant Synclinorium border, Belgium
Vanguestaine, M.; Pardo-Trujillo, A.; Coen-Aubert, M. et al

in Bollettino della Società Paleontologica Italiana (1999), 38(2-3), 317-330

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See detailLe Traçage : un outil pour l'établissement des zones de surveillance des captages en terrain karstique. Le cas de Hastière (Province de Namur, Belgique)
Michel, Goerges; Meus, Philippe ULg; Thys, Georges et al

in Bulletin de la Société Géographique de Liège (1999), 37

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in ... [more ▼]

In response to the request of the Groundwater Service of the Walloon Region, the Commission Wallonne d'Etude et de Protection des Sites Souterrains (CWEPSS) has carried out underground water tracing in the karstic area of Hastière (Province of Namur, Belgium).The CWEPSS has carried on the task with the cooperation of Geologica SA, Gembloux, for the tracing tests and the collaboration of the Université de Liège for several related parameters (stream gauging, water analyzes, spectrofluorimetry, etc.). At Hastière, several karstic Springs resurge from a large and complex limestone syncline; two water supply stations pump water from this syncline for local use. Fluorescent tracers have been injected into three swallowholes. Three different tracers have been used simultaneously - one in each injection site. They have been traced downstream in 9 potential points of reappearance. In a single one-month field-campaign, the origin of 9 streams has been questioned. Despite the low-water levels during this period, some underground streams have covered more than 3,5 km in 8 days. This shows how important is to permanently watch water supplies in karstic areas. The water intake of the Municipality at Anthée proved to be clean, unpolluted. The authors could define the watch-zone and delineate a prioritary watch sub-zone in the geological formation supplying directly the intake. A private camping intake appeared to be supplied by a sinkhole collecting water from a water purifying station and by another sinking stream swallowing sewage water, hence a high pollution and an important sanitary problem. These findings, among others, show how us « the water tracing technique is in detecting sources and in defining watch and protection zones. [less ▲]

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See detailComparing global models of terrestrial net primary productivity (NPP): analysis of the seasonal atmospheric CO2 signal
Nemry, B.; François, Louis ULg; Gérard, Jean-Claude ULg et al

in Global Change Biology (1999), 5(Suppl. 1), 65-76

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison ... [more ▼]

Eight terrestrial biospheric models (TBMs) calculating the monthly distributions of both net primary productivity (NPP) and soil heterotrophic respiration (R-H) in the Potsdam NPP Model Intercomparison workshop are used to simulate seasonal patterns of atmospheric CO2 concentration. For each model, we used net ecosystem productivity (NEP=NPP-R-H) as the source function in the TM2 atmospheric transport model from the Max-Planck Institute for Meteorology. Comparing the simulated concentration fields with detrended measurements from 25 monitoring stations spread over the world, we found that the decreasing seasonal amplitude from north to south is rather well reproduced by all the models, though the amplitudes are slightly too low in the north. The agreement between the simulated and observed seasonality is good in the northern hemisphere, but poor in the southern hemisphere, even when the ocean is accounted for. Based on a Fourier analysis of the calculated zonal atmospheric signals, tropical NEP plays a key role in the seasonal cycle of the atmospheric CO2 in the whole southern hemisphere. The relatively poor match between measured and predicted atmospheric CO2 in this hemisphere suggests problems with all the models. The simulation of water relations, a dominant regulator of NEP in the tropics, is a leading candidate for the source of these problems. [less ▲]

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See detailComment j'explore ... un trouble de la kaliémie
Neven, Ingrid; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(12), 943-947

Potassium is the most important intracellular cation,playing a role in neuromuscular excitability. Dyskaliema is common. The consequence of this ionic perturbation could be serious related to its ... [more ▼]

Potassium is the most important intracellular cation,playing a role in neuromuscular excitability. Dyskaliema is common. The consequence of this ionic perturbation could be serious related to its magnitude. Thus a quick etiological approach and a medical intervention are needed to rapidly correct this potentially lethal ionic disturbance and prevent its recurrence. [less ▲]

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See detailMcLuhan, trente ans après
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailMolecular Evidence For An Andean Origin And A Secondary Gene Pool For The Lima Bean (Phaseolus Lunatus L..) Using Chloroplast Dna
Fofana, B.; Baudoin, Jean-Pierre ULg; Vekemans, X. et al

in Theoretical and Applied Genetics (1999), 98(2),

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See detailEffect of feeding lambs with fat rapessed meal on the quality of their depot fat.
Wathelet, Jean-Paul ULg; Mabon, N.; Marlier, M.

in GCIRC Bulletin (1999)

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See detailLe quiproquo de la consommation medicale de la femme.
Gillet, Pierre ULg; Tellier, V.

in Revue Médicale de Liège (1999), 54(4), 214-23

By analysing three different Belgian databases, we could demonstrate that whereas women subjectively declare a higher number of diseases, a worse functional state and a higher trend to use medical ... [more ▼]

By analysing three different Belgian databases, we could demonstrate that whereas women subjectively declare a higher number of diseases, a worse functional state and a higher trend to use medical resources, they are, from an objective point of view, less frequently hospitalized and cause a lower cost, at certain ages, for the Social Security. [less ▲]

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See detailLa transposition de "quaestor" en grec
Famerie, Etienne ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

Critical survey of the three different ways (transliteration, translation, equivalence) to transpose a Latin technical term (quaestor, for example) into the Greek language

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See detailDecreased Corticosensitivity in Quiescent Crohn's Disease: An Ex Vivo Study Using Whole Blood Cell Cultures
Franchimont, Denis; Louis, Edouard ULg; Dupont, Pierre et al

in Digestive Diseases & Sciences (1999), 44(6), 1208-15

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses ... [more ▼]

Corticosensitivity influences the degree and the duration of an inflammatory reaction by altering target cell responses to endogenous and/or exogenous glucocorticoids. Indeed, different clinical responses to glucocorticoids have been observed among patients with Crohn's disease, suggesting different degrees of corticosensitivity in these subjects. The purpose of this study was to compare the corticosensitivity of patients with quiescent Crohn's disease to that of healthy subjects (HS). Nineteen patients with quiescent Crohn's disease and 14 HS were studied; all patients were steroid-free for at least six months; 7 of the 19 were corticosteroid-dependent (CSD) and treated with nonglucocorticoid immunosuppressants at the time of the study. Corticosensitivity was measured by the inhibition of LPS-induced cytokine secretion in whole blood cell cultures treated with increasing concentrations (10(-9) to 10(-6) M) of dexamethasone. Tumor-necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) were measured using specific immunoassays. Crohn's disease patients had a markedly decreased dexamethasone-mediated inhibition of TNF-alpha (P < 0.01), IL-6 (P < 0.001), and IL-1 beta (P < 0.01) compared to healthy subjects, with a shift of the dexamethasone dose-response curve to the right. No significant differences in the basal and LPS-stimulated secretion of the three cytokines were observed between CSD and non-CSD patients, and both subgroups of patients had similar degrees of dexamethasone-mediated cytokine inhibition. We conclude that patients with Crohn's disease have a significant decrease in the corticosensitivity of their leukocytes. This may be related to a specific genetic/constitutional background and/or could be acquired, due to inflammation-related endocrine and/or immune factors. [less ▲]

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See detailLa guerre du tabac : Francorchamps contre-attaque
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailMachiavellian Rethoric. From the Counter-Reformation to Milton, Princeton.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1999)

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See detailValue of FDG-PET in detecting residual or recurrent nonsmall cell lung cancer
Bury, Thierry ULg; Corhay, Jean-Louis ULg; Duysinx, Bernard ULg et al

in European Respiratory Journal (1999), 14(6), 1376-1380

In order to evaluate the usefulness of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the assessment of therapeutic effects, a study was performed before and after therapy in 126 ... [more ▼]

In order to evaluate the usefulness of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) in the assessment of therapeutic effects, a study was performed before and after therapy in 126 patients with non-small cell lung cancer (NSCLC) codified stage I to stage IIIB. Treatment with an early curative result was given in 58 patients, whereas in 68 cases it was limited to palliation. During the treatment follow-up period (8-40 months), each patient was evaluated every 3 months by clinical examination and ≤6 months by imaging techniques (PET and computed tomography (CT)). A diagnosis of persistent or recurrent tumour was established by means of pathological analysis in 31 patients and by clinical evolution and subsequent imaging progression in 29 other patients. PET showed increased FDG uptake in all cases (n=60) of persistent or recurrent tumour, whereas CT was nonspecific in 17 cases. Conversely, there were five false positive cases via PET imaging and three via CT. In detecting residual or recurrent NSCLC, PET had a sensitivity of 100% and specificity of 92%, whereas CT had a sensitivity and specificity of 71% and 95% respectively. In conclusion, 18-fluorodeoxyglucose positron emission tomography correctly identified response to therapy in 96% (121 of 126) of patients. Positron emission tomography appears to be more accurate (p=0.05) than conventional imaging in distinguishing persistent or recurrent tumour from fibrotic scar in patients undergoing treatment for non-small cell lung cancer. [less ▲]

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See detailMimicry and the judgment of emotional facial expression
Blairy, Sylvie ULg; Herrera, P; Hess, U

in Journal of Nonverbal Behavior (1999), 23(1), 5-41

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See detailTroglitazone: antihyperglycemic activity and potential role in the treatment of type 2 diabetes.
Scheen, André ULg; Lefebvre, Pierre ULg

in Diabetes Care (1999), 22(9), 1568-77

Insulin resistance is a major component of type 2 diabetes; therefore, an insulin sensitizer agent like the thiazolidinedione compound troglitazone is considered a very promising drug. Troglitazone exerts ... [more ▼]

Insulin resistance is a major component of type 2 diabetes; therefore, an insulin sensitizer agent like the thiazolidinedione compound troglitazone is considered a very promising drug. Troglitazone exerts an antihyperglycemic activity in a dose-dependent manner between 200 and 600 mg/day in type 2 diabetic patients treated with diet alone, sulfonylureas, or insulin. Additive antihyperglycemic effect may also be obtained by combining troglitazone and metformin. The antihyperglycemic effect of troglitazone as monotherapy is rather modest (reduction of HbA1c by 0.5-1.0%), but it appears to be somewhat greater when it is combined with other antidiabetic drugs. No double-blind studies have directly compared the activity of troglitazone with that of sulfonylureas or metformin. Troglitazone has been shown to exert additional beneficial effects on serum lipid profile and arterial blood pressure. It may be considered as a valuable alternative in insulin-resistant (obese and hyperinsulinemic) diabetic patients who appear to be the best responders to the drug. However, the efficacy of troglitazone is challenged by its safety profile, and the risk of hepatotoxicity still remains a major concern in clinical practice. [less ▲]

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See detailProphylactic Use of Alfacalcidol in Corticosteroid-Induced Osteoporosis
Reginster, Jean-Yves ULg; Kuntz, D.; Verdickt, W. et al

in Osteoporosis International (1999), 9(1), 75-81

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients ... [more ▼]

One hundred and forty-five patients suffering from diseases requiring long-term treatment with high doses of corticosteroids (30 mg/day or greater of prednisolone) were recruited to the study. Patients had to be steroid naive on entry to the study (not more than 15 days of treatment with a corticosteroid within the previous 24 months). Patients were randomized to receive either 1 microgram/day alfacalcidol or placebo capsules for 12 months. Bone mineral density (BMD) of the lumbar spine was assessed by dual-photon absorptiometry on entry and after 3, 6 and 12 months' treatment. Safety was monitored by the recording of all adverse events reported by patients and the regular screening of blood samples for hematology and serum biochemistry. Of the 145 patients, 74 were randomized to alfacalcidol and 71 to placebo. The treatment groups were well matched at baseline with no significant differences in demographic, clinical or biochemical parameters. The mean equivalent dose of prednisolone at baseline was 46.6 mg/day and 46.3 mg/day for the alfacalcidol and placebo group respectively. From the 145 patients randomized to treatment, 71 (38 who received alfacalcidol and 33 who received placebo) provided BMD data both at baseline and at 3, 6 and 12 months. The percentage change in BMD after 6 months' treatment was -2.11% in the alfacalcidol group and -4.00% in the placebo group (p = 0.39). After 12 months the percentage change in BMD was +0.39% (CI: -4.28 to 4.81) in the alfacalcidol group and -5.67% (CI: -8.13 to -3.21) in the placebo group, this difference (6.06%, CI: 0.88 to 11.24) being statistically significant (p = 0.02). An intention to treat analysis also showed a significant difference between the two treatment groups in alfacalcidol's favor (3.81%, p = 0.01; CI: 0.92 to 6.70). There was no significant difference between the two treatment groups in the corticosteroid dose at any time point during the study. Serum calcium was measured throughout and there were no significant differences between the two treatment groups at any visit. This study suggests that alfacalcidol can prevent corticosteroid-induced bone loss from the lumbar spine. Long-term use of alfacalcidol was not associated with any significant adverse effects in this diverse group of patients. [less ▲]

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See detailNon-alcoholic steatohepatitis.
Luyckx, Françoise ULg; Scheen, André ULg; Lefebvre, Pierre ULg

in Lancet (1999), 354(9186), 1298-9

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See detailLa cartographie des contraintes karstiques en Région wallonne (Belgique)
Ek, Camille ULg; Michel, Raymond; Jaspar, Annick

in Bulletin de la Société Géographique de Liège (1999), 36

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See detailAnalysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms.
Wang, Xingjun ULg; Tromp, G.; Cole, C. W. et al

in Matrix Biology (1999), 18(2), 121-4

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of ... [more ▼]

Aneurysms are characterized by dilation, i.e. expansion and thinning of all the arterial wall layers, which is accompanied by remodeling of the connective tissue. Genes involved in the regulation of tissue remodeling are therefore candidate genes. We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals. We identified two nucleotide variants in both the TIMP1 and the TIMP2 coding sequences. All differences occurred in the third base positions of codons and were neutral polymorphisms. A significant difference was observed in the frequency of TIMP2 nt 573 polymorphism between 168 alleles from AAA patients and 102 control alleles. [less ▲]

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See detailSevere/extreme obesity: a medical disease requiring a surgical treatment?
Scheen, André ULg; Luyckx, Françoise ULg; Desaive, Claude ULg et al

in Acta Clinica Belgica (1999), 54(3), 154-61

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with ... [more ▼]

Obesity poses a serious health hazard and its treatment is often disappointing. Surgical approaches have been proposed for treating severe obesity (body mass index or BMI > or = 35 kg/m2) with comorbidities or extreme obesity (BMI > or = 40 kg/m2). Before accepting bariatric surgery as alternative treatment, the four following prerequisites should be met: 1. the medical condition is serious enough; 2. it can not be treated satisfactorily with classical means; 3. the surgical treatment is effective in improving the clinical situation; and 4. bariatric surgery is safe enough, so that the benefits clearly outweigh the risks. On the basis of the literature and our own experience, it appears that gastric reduction surgery may be considered as a valuable alternative for treating severe/extreme obesity, despite the possible occurrence of perioperative and, more frequently, late complications, provided that it is performed by an experienced and multidisciplinary team in well-selected patients. [less ▲]

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See detailMise au point d'un test d'évaluation gestuelle du patient lombalgique
Vanderthommen, Marc ULg; DEFAWEUX, Michel ULg; TOMASELLA, Marco ULg et al

in Revue de la Société Belge des Ecoles du Dos (1999)

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See detailL'art et la ville
Duchesne, Jean-Patrick ULg

in Art&fact (1999), 19

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See detailBen Watson, Art, Class and Cleavage
Delville, Michel ULg

in Textual Practice (1999), 13

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See detailDual Harmonic and Time Approaches for the Design of Microwave Devices
Meys, B.; Geuzaine, Christophe ULg; Henrotte, F. et al

in IEEE Transactions on Magnetics (1999), 35(3), 1829--1832

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See detailPotentiation of cytotoxicity and radiosensitization of (E)-2'-deoxy-2' (fluoromethylene) cytidine by pentoxifylline in vitro.
LI, Y-X; Sun, L-Q; Paschoud, N et al

in International Journal of Cancer = Journal International du Cancer (1999), 80

(E)-28-deoxy-28-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide-diphosphate reductase, has been shown to have anti-tumor activity against solid tumors and sensitize tumor cells to ... [more ▼]

(E)-28-deoxy-28-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide-diphosphate reductase, has been shown to have anti-tumor activity against solid tumors and sensitize tumor cells to ionizing radiation. Pentoxifylline (PTX) can potentiate the cell killing induced by DNAdamaging agents through abrogation of DNA-damagedependent G2 checkpoint. We investigated the cytotoxic, radiosensitizing and cell-cycle effects of FMdC and PTX in a human colon-cancer cell line WiDr. PTX at 0.25–1.0 mM enhanced the cytotoxicity of FMdC and lowered the IC50 of FMdC from 79 6 0.1 to 31.2 6 2.1 nM, as determined by MTT assay. Using clonogenic assay, pre-irradiation exposure of exponentially growing WiDr cells to 30 nM FMdC for 48 hr or post-irradiation to 0.5 to 1.0 mM PTX alone resulted in an increase in radiation-induced cytotoxicity. Moreover, there was a significant change of the radiosensitization if both drugs were combined as compared with the effect of either drug alone. Cell-cycle analysis showed that treatment with nanomolar FMdC resulted in S-phase accumulation and that such an S-phase arrest can be abrogated by PTX. Treatment with FMdC prior to radiation increased post-irradiation-induced G2 arrest, and such G2 accumulation was also abrogated by PTX. These results suggest that pharmacological abrogation of S and G2 checkpoints by PTX may provide an effective strategy for enhancing the cytotoxic and radiosensitizing effects of FMdC. Int. J. Cancer 80:155–160, 1999. [less ▲]

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See detailIncreased number of hip fractures.
Gillet, Pierre ULg; Reginster, Jean-Yves ULg

in Lancet (1999), 353(9170), 2160-1

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See detailH-1-N-15 HMQC for the identification of metal-bound histidines in Cd-113-substituted Bacillus cereus zinc beta-lactamase
Damblon, Christian ULg; Prosperi, Christelle ULg; Lian, L. Y. et al

in Journal of the American Chemical Society (1999), 121(49), 11575-11576

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See detailIGF-II in primary human colorectal tumors: peptide level, activated promoters, parental imprinting and gene rearrangement.
Winkler, Rose ULg; Delacroix, Laurence ULg; Bensbaho, K. et al

in Hormone & Metabolic Research (1999), 31(2-3), 148-54

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary ... [more ▼]

IGF-II is a polypeptide growth factor with growth and differentiation promoting activities, involved in human development. We have reported previously IGF-II mRNA and peptide overexpression in primary human colon cancers. Here we show that the IGF-II peptide content is increased in six primary colon cancers compared to the corresponding healthy tissues. The IGF-II transcripts in healthy and cancerous colon tissues were identified by Northern blotting and RT-PCR. Promoters P3 and P4 were active in most tissues. Relaxation of parental imprinting was observed in two tumors and one healthy tissue, without any correlation with the IGF-II transcript levels. Rearrangements of the IGF-II gene in two tumors containing very high amounts of IGF-II mRNA are described. Fragments containing the breakpoints were cloned by the vectorette-PCR strategy. In both tumors, the breakpoints occurred in repetitive sequences. In one tumor (T11), the breakpoint was localized 2 kb downstream the end of exon 9. The second tumor (T18) contains two modified alleles. In one rearranged allele the breakpoint is located in exon 9. The exact position of the breakpoint in the second rearranged allele has not been identified. In future experiments, the correlation between the gene rearrangements and IGF-II mRNA overexpression will be studied. [less ▲]

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See detailTowards Marker Assisted Selection in Livestock
Georges, Michel ULg

in Reproduction Nutrition Development (1999), 39(5-6, Sep-Dec), 555-61

In recent years, genomic tools have become available for most livestock species and are now being used routinely to map quantitative trait loci underlying the genetic variance for numerous economically ... [more ▼]

In recent years, genomic tools have become available for most livestock species and are now being used routinely to map quantitative trait loci underlying the genetic variance for numerous economically important traits. Fine-mapping methods are being devised to refine the initially coarse map positions of the quantitative trait loci to the point required for marker assisted selection and, eventually, the positional cloning of the underlying genes. Mapping information on QTL is beginning to be used to increase genetic response by enhancing genetic variance, selection accuracy, selection intensity and by reducing the generation interval. Optimal use of MAS will require the development of more robust methods for the routine genotyping of preimplantation embryos for multiple markers. [less ▲]

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See detailEvidence for vortex staircases in the whole angular range due to competing correlated pinning mechanisms
Silhanek, Alejandro ULg; Civale, L.; Candia, S. et al

in Physical Review. B : Condensed Matter (1999), 59(21), 13620-13623

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum ... [more ▼]

We present measurements of the angular dependence of the irreversible magnetization of YBa2Cu3O7 single crystals with columnar defects inclined with respect to the c axis. At high fields a sharp maximum centered at the tracks direction is observed. At low fields we identify a lock-in phase characterized by an angle-independent pinning strength and observe an angular shift of the peak towards the c axis that originates in the misalignment between vortices and applied field in anisotropic materials. The interplay among columnar defects, twins, and intrinsic pinning by the ab planes generates a variety of staircase structures. We show that correlated pinning dominates for all orientations of the applied field. [S0163-1829(99)09417-5]. [less ▲]

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See detailComparison of intracellular and extracellular particles of the vaccinia virus
Vanderplasschen, Alain ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154

The construction of recombinant vaccinia viruses (VV) is definitely a promising approach to develop vaccines for pets. To produce safer VV recombinant vaccines, it is necessary to understand the ... [more ▼]

The construction of recombinant vaccinia viruses (VV) is definitely a promising approach to develop vaccines for pets. To produce safer VV recombinant vaccines, it is necessary to understand the pathogenesis of VV infection. The goal of this study was to compare the biological properties of the extracellular and intracellular infectious particles of VV. Four biological properties were investigated: (i) the binding into cellular receptor(s); (ii) the mechanism of entry; (iii) the resistance to neutralisation by antibodies; (iv) the resistance to complement lysis. The results obtained in this study emphasize the differences existing between the two infectious forms of VV and demonstrate the adaptation of the extracellular particle to its role of virus dissemination in vivo. The results of this study implicate that VV strains used as expression vector in vaccinology should be deleted for genes required for EEV morphogenesis. [less ▲]

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See detailChanges in mediobasal hypothalamic gonadotropin-releasing hormone messenger ribonucleic acid levels induced by mating or ovariectomy in a reflex ovulator, the ferret.
Bakker, Julie ULg; Rubin, B. S.; Baum, M. J.

in Endocrinology (1999), 140(2), 595-602

The ferret is a reflex-ovulating species in which receipt of an intromission induces a prolonged (+/- 12 h) preovulatory LH surge in the estrous female. This LH surge is probably stimulated by a large ... [more ▼]

The ferret is a reflex-ovulating species in which receipt of an intromission induces a prolonged (+/- 12 h) preovulatory LH surge in the estrous female. This LH surge is probably stimulated by a large release of GnRH from the mediobasal hypothalamus (MBH). In Exp 1 we asked whether GnRH messenger RNA (mRNA) levels increase in response to mating so as to replenish the MBH GnRH stores needed to sustain the preovulatory LH surge. Estrous females were killed 0, 0.25, 0.5, 1, 3, 6, 14, or 24 h after the onset of a 10-min intromission from a male. Coronal brain sections ranging from the rostral preoptic area caudally to the posterior hypothalamus were processed for in situ hybridization using a 35S-labeled oligoprobe complementary to the human GnRH-coding region. We found no evidence of increased MBH GnRH mRNA levels during the ferret's mating-induced preovulatory LH surge. Instead, the number of GnRH mRNA-expressing cells dropped significantly in the arcuate region beginning 6 h after onset of intromission and remained low thereafter. Furthermore, cellular GnRH mRNA levels decreased in the arcuate region toward the end of the preovulatory LH surge. In Exp 2 we asked whether ovarian hormones regulate MBH GnRH mRNA levels in the female ferret. Ovariectomy of estrous females significantly reduced the number of GnRH mRNA-expressing cells in the arcuate region. This decrease was probably not due to the absence of circulating estradiol. Gonadally intact anestrous females had levels of MBH GnRH mRNA similar to those in estrous females even though plasma estradiol levels were equally low in anestrous females and ovariectomized females. Ovarian hormones other than estradiol may stimulate MBH GnRH mRNA levels in anestrous and estrous females. [less ▲]

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See detailSistema familiare e disturbi del comportamento alimentare: dati preliminari di una ricerca.
Onnis, Luigi; Di Gennaro, A.; Antenucci, M. et al

in Psichiatria (1999)

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See detailContribution de l'hypertension arterielle au risque vasculaire du diabetique.
Marre, M.; Bouhanick, B.; Hadjadj, S. et al

in Diabètes & Métabolism (1999), 25 Suppl 3

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence ... [more ▼]

Hypertension is a major cardiovascular risk factor in diabetic subjects. Recent trials have suggested that blood pressure objectives should be < or = 140/80 mmHg. However, there is currently no evidence supporting any particular preferential drug strategy for this treatment objective. [less ▲]

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See detailCompte-rendu de l'ouvrage de Bawin-Legros Bernadette : Familles modes d'emploi. Étude sociologique des ménages belges
Orianne, Jean-François ULg

in Recherches Sociologiques et Anthropologiques (1999), (3),

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See detailBovine herpesvirus 1-induced apoptotic cell death: role of glycoprotein D
Hanon, Emmanuel; Keil, Günther; Van Drunen Littel-Van Den Hurk, Sylvia et al

in Virology (1999), 257

Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in peripheral blood mononuclear cells and in bovine B lymphoma (BL-3) cells. Attachment but not penetration of BHV-1 is necessary to induce ... [more ▼]

Bovine herpesvirus 1 (BHV-1) induces apoptotic cell death in peripheral blood mononuclear cells and in bovine B lymphoma (BL-3) cells. Attachment but not penetration of BHV-1 is necessary to induce apoptosis in target cells, suggesting that one or more BHV-1 envelope glycoproteins could be involved in the activation of the apoptotic process. In the present study, we demonstrate that, although BHV-1 virions devoid of glycoprotein D (BHV-1 gD-/-) still bind to BL-3 cells, they are no longer able to induce apoptosis. In contrast, virions that contain glycoprotein D (gD) in the viral envelope but do not genetically encode gD (BHV-1 gD-/+) induce a level of apoptosis comparable to that produced by wild-type (wt) BHV-1. In addition, monoclonal antibodies directed against gD, but not against gB or gC, strongly reduced the high levels of apoptosis induced by BHV-1. These observations demonstrate that the induction of apoptosis is directly due to BHV-1 viral particles harboring gD in the viral envelope. Interestingly, binding of affinity-purified gD to BL-3 cells did not induce apoptosis but inhibited the ability of wt BHV-1 to induce apoptosis. Altogether, these results provide evidence for the direct or indirect involvement of gD in the mechanism by which BHV-1 induces apoptosis. [less ▲]

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