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See detailItinéraire d’une fable : le Loup et le Chien
Pietquin, Paul ULg; Dachy, Françoise; Debrux, Thomas et al

in Etudes Classiques (Namur, Belgium) (1994), 62

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See detailNote sous l'arrêt de la CJCE du 19 janvier 1994, Eurocontrol
Partsch, Philippe-Emmanuel ULg

in Journal des Tribunaux Droit Européen (1994)

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See detailAspects épidémiologiques du suicide
Gosset, Christiane ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), 2

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See detailL'inventaire forestier régional wallon: brève présentation méthodologique.
Lecomte, H.; Rondeux, Jacques ULg

in Silva Belgica (1994), 101(6), 9-16

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie ... [more ▼]

Au début des années 1980, à l’initiative de la Faculté des Sciences agronomiques de Gembloux et grâce à un financement de la Région Wallonne, un inventaire a été réalisé sur l’ensemble de la Wallonie [RONDEUX et al., 1984]. Cet inventaire s’appuyant sur un échantillonnage systématique simple était destiné à fournir un état des lieux de la forêt wallonne de l’époque ; il a notamment permis de confirmer ou de mettre en évidence plusieurs éléments essentiels pour l’avenir du patrimoine forestier wallon [RONDEUX et al., 1986] : - le vieillissement de la hêtraie ardennaise ; - l’importante disponibilité en bois d’épicéa ; - les écarts entre les surfaces forestières observées et celles du recensement officiel. Depuis la fin de cet inventaire en 1984, aucune mise à jour n’a été programmée et en conséquence, ses résultats ont perdu leur fiabilité notamment en raison des accidents météorologiques de la dernière décennie. En 1988, l’Exécutif de la Région Wallonne, conscient de l’importance de la forêt en tant que première ressource naturelle renouvelable de la Wallonie, a sollicité la Faculté des Sciences agronomiques de Gembloux en vue de finaliser une recherche destinée à concevoir une méthodologie d’inventaire forestier permanent. Les conclusions de cette étude ont été déposées fin 1993 [LECOMTE, 1994], ce qui a permis de lancer dès février 1994 la phase opérationnelle du premier inventaire forestier permanent pour la Wallonie. Dans les lignes qui suivent, nous aborderons successivement les objectifs de l’inventaire (paragraphe 2) ainsi que les principes généraux qui le régissent (paragraphe 3). Le cheminement de l’information sera décrit depuis la récolte des données (paragraphe 4) jusqu’à la publication des résultats (paragraphe 7) en passant par le traitement et l’exploitation des données (paragraphes 5 et 6). En guise de conclusions, nous émettrons quelques réflexions issues de notre propre expérience (paragraphe 8). [less ▲]

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See detailLaparoscopic adrenalectomy in pheochromocytoma and Cushing's syndrome. Reflections about two case reports.
Meurisse, Michel ULg; Joris, Jean ULg; Hamoir, Etienne ULg et al

in Acta Chirurgica Belgica (1994), 94(6), 301-6

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open ... [more ▼]

Laparoscopic adrenalectomy is possible as well on the left as on the right side using a percutaneous transabdominal approach. The exposure of the glands seems better than it could be achieved with an open method. In combination with intraoperative infusion of nicardipine, a calcium-channel blocker, the laparoscopic removal of a pheochromocytoma was performed safely and under stable conditions. In case of Cushing's syndrome, the laparoscopic approach reduces the problems related to poor healing. In all cases of laparoscopic adrenalectomy, this approach could offer the clear advantages of smaller incisions, reduced postoperative pain and incisional discomfort as well as complications related to large and invasive procedure and finally allows quicker recovery. Moreover, conversion to open surgery remains always possible, if needed. [less ▲]

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See detailLe contrôle de l'infection par le virus de la rhinotrachéite infectieuse bovine
Lemaire, Mylène; Pastoret, Paul-Pierre ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailMechanisms of dexamethasone-induced insulin resistance in healthy humans.
Tappy, L.; Randin, D.; Vollenweider, P. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(4), 1063-9

Insulin resistance may result from decreased muscle blood flow, impaired cellular glucose transport, or intracellular deficits of glucose metabolism. The mechanisms responsible for dexamethasone-induced ... [more ▼]

Insulin resistance may result from decreased muscle blood flow, impaired cellular glucose transport, or intracellular deficits of glucose metabolism. The mechanisms responsible for dexamethasone-induced insulin resistance were investigated in healthy human subjects. During a 2-h hyperinsulinemic clamp, dexamethasone decreased glucose uptake, oxidation, and nonoxidative glucose disposal during the first hour. During the second hour, glucose uptake was normalized by means of hyperglycemia; glucose oxidation, however, remained suppressed by dexamethasone. Dexamethasone also abolished the insulin-mediated increase in calf blood flow. When acipimox was administered during the clamps to correct glucocorticoid-induced inhibition of glucose oxidation, dexamethasone decreased whole body glucose uptake and nonoxidative glucose disposal in the same proportion as when no acipimox was administered. However, glucose oxidation and insulin-mediated calf blood flow were normalized after acipimox. During the second hour, exogenous glucose infusion was matched to that used in the control clamp and normalized whole body glucose uptake. However, hyperglycemia developed, indicating insulin resistance. It is concluded that dexamethasone 1) decreases glucose oxidation independently of glucose transport; this inhibition is reversed by acipimox; and 2) decreases whole body glucose uptake independently of increased lipolysis, decreased glucose oxidation, or an altered muscle blood flow. [less ▲]

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See detailMacrofagos y factor de necrosis tumoral alfa en la necrolisis epidermica toxica
Paquet, Philippe ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Archives of Dermatology (1994), 5

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular ... [more ▼]

ANTECEDENTES: Estudiamos las características inmunopatològicas de 5 casos de necrólisis epidérmica tóxica utilizando un amplio panel de anticuerpos. OSERVACIONES: El patrón y grado del infiltrado celular inflamatorio varió dependiendo del estado de la enfermedad. La principal característica constante fue la importante implicación de la línea monocito-macrófago, incluyendo dendrocitos factor XIIIa+ HLA-DR+ y macrófagos CD68+ Mac 387+, antes y durante la necrosis epidérmica. El número de linfocitos CD4+ y CD8+ era comparativamente reducido. Ello se asociaba con un denso marcaje para el factor de necrosis tumoral alfa en la epidermis. CONCLUSIONES: Las células de estirpe monocito-macrófago superan en nùmero ampliamente a los linfocitos en las lesiones de la necrólisis epidérmica tóxica. El factor de necrosis tumoral alfa es problablemente una de las citocinas principales responsables de la necrosis. [less ▲]

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See detailLes spermatozoïdes ont-ils du nez ?
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Parmentier, M. et al

in Medecine Sciences : M/S (1994), 10

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See detailLe plan régional d'aménagement du territoire wallon
Delnoy, Michel ULg; Pâques, Michel ULg

in Aménagement - Environnement (1994), n° spécial

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See detailComment on the paper "Oscillator Strengths for Some Systems with the ns2np ground-state configuration: II. Gallium Isoelectronic Sequence
Biémont, Emile ULg; Marcinek, R.; Migdalek, J. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailGestion d'un épisode de peste porcine classique en Belgique
Vanthemsche, P.; Saegerman, Claude ULg

in Epidémiologie et Santé Animale (1994), 26

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See detailMeasurement of insulin sensitivity by the minimal model method using a simplified intravenous glucose tolerance test: validity and reproducibility.
Duysinx, Bernard ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Diabète & Métabolisme (1994), 20(4), 425-32

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's ... [more ▼]

This study aimed at testing whether 12 rather than 26 plasma glucose and insulin determinations can be used to calculate the indices of insulin sensitivity and of glucose effectiveness using Bergman's minimal model during a simple intravenous glucose tolerance test performed without tolbutamide injection. Two intravenous glucose tolerance tests (separated by 1 week) were performed in 7 lean normal subjects and a single test was performed in 9 severely obese non-diabetic subjects. Intra-subject reproducibility of insulin sensitivity was not significantly different when 26 or 12 time-points were analyzed (CV = 16.8 +/- 3.4 versus 18.9 +/- 3.8% respectively). Compared with the insulin sensitivity of the lean subjects, that of obese subjects was significantly (P < 0.001) and similarly reduced when using 12 (2.14 +/- 0.34 versus 7.97 +/- 1.29 10(-4)min-1/mU.1-1) rather than 26 determinations (2.13 +/- 0.42 versus 6.95 +/- 1.12 10(-4) min-1/mU.1-1) respectively. Glucose effectiveness was less reproducible than insulin sensitivity and was slightly diminished by the reduction of blood samples (relative error: -9.7 +/- 4.4%; P < 0.05). Finally, glucose effectiveness tended to be slightly lower in the morbidly obese subjects than in the lean controls with both modes of calculation. In conclusion, in non-diabetic subjects, the insulin sensitivity index can be accurately measured during a simple intravenous glucose tolerance test, without tolbutamide injection and with only 12 blood samples. The possibility of performing a simplified test should contribute to increase the use of the minimal model method for estimating insulin sensitivity in clinical practice. [less ▲]

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See detailC.R. de La Passion du Palatinus. Mystère du XVe siècle.
Henrard, Nadine ULg

in Lettres Romanes (1994), XLVIII(3-4), 376-377

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See detailLa monadologie, une théorie de la communication basée sur l'opacité?
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1994)

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See detailConflits collectifs et recours juridictionnels
Kefer, Fabienne ULg

in Journal des Tribunaux (1994)

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See detailEnergy Levels in Ar II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Physical Review. A (1994), 49

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See detailEpidural anesthesia impairs both central and peripheral thermoregulatory control during general anesthesia.
Joris, Jean ULg; Ozaki, Makoto; Sessler, Daniel I et al

in Anesthesiology (1994), 80(2), 268-77

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after ... [more ▼]

BACKGROUND: The authors tested the hypotheses that: (1) the vasoconstriction threshold during combined epidural/general anesthesia is less than that during general anesthesia alone; and (2) after vasoconstriction, core cooling rates during combined epidural/general anesthesia are greater than those during general anesthesia alone. Vasoconstriction thresholds and heat balance were evaluated under controlled circumstances in volunteers, whereas the clinical importance of intraoperative thermoregulatory vasoconstriction was evaluated in patients. METHODS: Five volunteers were each evaluated twice. On one of the randomly ordered days, epidural anesthesia (approximately T9 dermatomal level) was induced and maintained with 2-chloroprocaine. On both study days, general anesthesia was induced and maintained with isoflurane (0.7% end-tidal concentration), and core hypothermia was induced by surface cooling and continued for at least 1 h after fingertip vasoconstriction was observed. Patients undergoing colorectal surgery were randomly assigned to combined epidural/enflurane anesthesia (n = 13) or enflurane alone (n = 13). In appropriate patients, epidural anesthesia was maintained by an infusion of bupivacaine. The core temperature that triggered fingertip vasoconstriction identified the threshold. RESULTS: In the volunteers, the vasoconstriction threshold was 36.0 +/- 0.2 degrees C during isoflurane anesthesia alone, but significantly less, 35.1 +/- 0.7 degrees C, during combined epidural/isoflurane anesthesia. Cutaneous heat loss and the rates of core cooling were similar 30 min before vasoconstriction with and without epidural anesthesia. In the 30 min after vasoconstriction, heat loss decreased 33 +/- 13 W when the volunteers were given isoflurane alone, but only 8 +/- 16 W during combined epidural/isoflurane anesthesia. Similarly, the core cooling rates in the 30 min after vasoconstriction were significantly greater during combined epidural/isoflurane anesthesia (0.8 +/- 0.2 degrees C/h) than during isoflurane alone (0.2 +/- 0.1 degrees C/h). In the patients, end-tidal enflurane concentrations were slightly, but significantly, less in the patients given combined epidural/enflurane anesthesia (0.6 +/- 0.2% vs. 0.8 +/- 0.2%). Nonetheless, the vasoconstriction threshold was 34.5 +/- 0.6 degrees C in the epidural/enflurane group, which was significantly less than that in the other patients, 35.6 +/- 0.8 degrees C. When the study ended after 3 h of anesthesia, patients given combined epidural/enflurane anesthesia were 1.2 degrees C more hypothermic than those given general anesthesia alone. The rate of core cooling during the last hour of the study was 0.4 +/- 0.2 degrees C/h during combined epidural/enflurane anesthesia, but only 0.1 +/- 0.3 degrees C/h during enflurane alone. CONCLUSIONS: These data indicate that epidural anesthesia reduces the vasoconstriction threshold during general anesthesia. Furthermore, the markedly reduced rate of core cooling during general anesthesia alone illustrates the importance of leg vasoconstriction in maintaining core temperature. [less ▲]

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See detailThymus Involvement in Murine Acquired Immunodeficiency (Maids)
Colombi, Sonia; Deprez, Manuel ULg; de Leval, Laurence ULg et al

in Thymus (1994), 23(1), 27-37

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced ... [more ▼]

Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced cytopathic effects on T-cells in the periphery. Therefore, thymus weight, cell numbers, and subset distribution were sequentially analysed after infection with RadLV-Rs, a viral mixture known to induce murine retrovirus induced immunodeficiency (MAIDS). Infection induced thymic atrophy (concerning organ weight as well as total cell number) which culminated seven weeks after inoculation. The atrophic process mostly reflected the depletion of double positive CD4+ CD8+ cells since their proportion sharply decreased around week 6. Single positive T-cells were less affected by the process. The proportion of B-cells progressively increased. Surprisingly, there was a strong correlation between the extent of atrophy and the frequency of B-cells in the thymus. Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ. [less ▲]

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See detailMadin Darby Bovine Kidney Cell Synchronization by Lovastatin: Application to Bovine Herpesvirus-1 Gene Expression
Vanderplasschen, Alain ULg; Hanon, E.; Benarafa, C. et al

in Veterinary Research (1994), 25(6), 555-67

The number of investigations involving cell proliferation has increased rapidly in the last years. One of the major difficulties in studying cell-cycle-related events is obtaining highly synchronous cell ... [more ▼]

The number of investigations involving cell proliferation has increased rapidly in the last years. One of the major difficulties in studying cell-cycle-related events is obtaining highly synchronous cell populations without metabolic imbalance. This study demonstrates that the Madin Darby bovine kidney (MDBK) cells, a commonly used cell line in veterinary research, can be effectively synchronized using lovastatin (Lov), a drug used to treat hypercholesteremia in humans. This was demonstrated by the following results: (i) Lov inhibits cell proliferation in a dose-dependent manner; (ii) Lov synchronizes MDBK cells mainly in the G1 and secondarily in the G2+M cell-cycle phases; (iii) the cytostatic effect of Lov can be specifically inhibited by addition of mevalonate (Mev) (Lov inhibits the synthesis of Mev); (iv) removal of Lov from G1-arrested cultures, followed by addition of Mev, resulted in the synchronous recovery of DNA synthesis; and (v) 5-bromo2'-deoxyuridine incorporation experiments revealed that MDBK cells synchronization by Lov can be followed for at least 3 cycles after removal of Lov and addition of Mev. Furthermore, as an application of investigations based on the availability of synchronized MDBK, we showed that bovine herpesvirus-1 gene expression is independent on the cell cycle. [less ▲]

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See detailChoix d'une nouvelle variete pour les zones cotonnieres meridionales du Zaire. Resultats des essais varietaux preliminaires.
Mergeai, Guy ULg; Ndungo, V.; Folo, A. et al

in Bulletin des Recherches Agronomiques de Gembloux (1994), 29(4),

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See detailL'analyse des glucosinolates, travaux réalisés par l'Organisation internationale de standardisation et la CEE
Wathelet, Jean-Paul ULg; Ribaillier, Daniel; Severin, Michel et al

in Bulletin du GCIRC (1994)

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See detailSpecific DNA probes to detect Escherichia coli strains producing cytotoxic necrotising factor type 1 or type 2
Oswald, E.; Pohl, P.; Jacquemin, E. et al

in Journal of Medical Microbiology (1994), 40

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See detailDémographie du martin pêcheur (Alcedo atthis): incidences climatiques sur le succès reproducteur
Libois, Roland ULg

in Gerfaut (Le) = Giervalk (De) (1994), 84

It is well known that the Kingfisher populations decrease dramatically after a sever winter. The recovery depends on the climatic conditions of the next reproductive seasons. In order to understand the ... [more ▼]

It is well known that the Kingfisher populations decrease dramatically after a sever winter. The recovery depends on the climatic conditions of the next reproductive seasons. In order to understand the mechanism involved in this climatic influence, the fate of more than 500 broods was studied between 1985 and 1993. The study area comprises the river Meuse from Vireux (F,08) downstreams to Huy (B Liège) and the lower part of its main tributaries. The first egg laying date was determined for each brood, eggs were counted, pulli ringed at nest and the adults controlled and ringed when possible. Our main conclusions are i : the beginning of the first clutch is correlated with the thermic conditions of March. ii : the clutches are not synchronised, even on a same watercourse. iii : the egg probuction and the hatching success don't show clear variations between years abd habitat types (river, ponds and small streams) or depending on the clutch rank. iv : the fledged young production depends on how much broods are raised by the different pairs. v : the probability a pair is attempting a thrid brood is function of how early the first clutch is layed, the age of the male (older males settle earlier and are more productive), the habitat quality and the weather conditions (rain, temperature) in May. [less ▲]

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See detailAnomalie pluviométrique négative sur le Sud-est du Zaïre en janvier 1992
Kalombo, K.; Erpicum, Michel ULg; Lahuec, J. P.

in Publications de l'Association Internationale de Climatologie (1994), 7

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See detailLe paradis d'une ville au siècle de Louis XIV
George, Philippe ULg

in Annales du Cercle Hutois des Sciences et Beaux-Arts (1994), XLVIII

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See detailPresence of gd TcR+ Tumor Infiltrating Lymphocytes (TILs) in One Case of Pediatric Osteogenic Sarcoma
Moutschen, Michel ULg; Jacobs, Nathalie ULg; Hoyoux, Claire ULg et al

in International Journal of Pediatric Hematology/Oncology (1994)

To characterize ab and gd TcR expression in cultured TILs from a metastatic osteogenic sar- coma.Patient and methods: TILs were isolated from a lung metastasis of an osteogenic sarcoma in a 16- year-old ... [more ▼]

To characterize ab and gd TcR expression in cultured TILs from a metastatic osteogenic sar- coma.Patient and methods: TILs were isolated from a lung metastasis of an osteogenic sarcoma in a 16- year-old female patient. Culture conditions were IL- 2 and anti-CD3 MoAb+IL-2. TcR expression and surface phenotype were studied by flow cytometry. 4h-chromium release assays were used to assess cytotoxicity. Results:IL-2-expanded tumor infiltrating T-lym- phocytes contained 50% gd TcR+ cells whereas gd TcR+ cells represented 20% of T-cells in cultures expanded with anti-CD3 MoAb+IL-2. The phenotype of gd TcR+ cells was CD3+, CD16-, CD4-, CD8-, and CD29+. AnH-CD3 MoAb + IL-2-expanded TILs mediated a significant lysis of thé autologous tumor and of an allogeneic lymphoma and displayed a higher activity against thé NK-sensitive target K562. In cold target experiments, unlabeled autol- ogous tumor cells blocked thé lysis of K562, indicating that MHC-unrestricted effectors were involved in thé lysis of both targets. Conclusions: This report demonstrates thé ex- pansion of large numbers of gd TcR+ T-cells after short-term culture of TILs from a metastatic os- teosarcoma. Further studies are needed to déter- mine thé role of gd TcR+ cells in host immune responses directed against this tumor. [less ▲]

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See detailSequencing And Analysis Of A 20.5-Kb Dna Segment Located On The Left Arm Of Yeast Chromosome-Xi
Vandenbol, Micheline ULg; Bolle, Pa.; Dion, C. et al

in Yeast (1994), 10

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See detailDistribution of plankton parameters in the north eastern North Sea in relation to vertical physical structures
Veeschkens, Christine; Belkhiria, Sami; Goffart, Anne ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 65-88

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See detailRound Table Conference on Mediators of Sepsis--Brussels, Belgium, March 21-23, 1992
Lamy, Maurice ULg; Thijs, L. G.

in Intensive Care Medicine (1994), 20(3), 238-41

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See detailMicroencapsulation by coacervation of poly(lactide-co-glycolide): Physico-chemical characteristics of the phase separation process
Stassen, S; Nihant, Nicole; Martin, Véronique et al

in Polymer (1994), 35(4), 777-785

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase ... [more ▼]

This paper describes the phase separation of different lactide and glycolide copolyester solutions, induced by the addition of silicone oil in order to promote protein microencapsulation. The phase diagrams of the ternary CH2Cl2-copolyester-silicone oil systems were established in relation to the composition of the copolyester and the viscosity, i.e. the molecular weight, of the silicone oil. The phase-separated systems were characterized in terms of weight, volume, composition and viscosity of the coacervation agent (silicone oil) on the characteristics of the phase-separated system is discussed. [less ▲]

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See detailMultiphase Saturation Curves of the Oxoglutarate Carrier : A mathematical Model
Holzhütter, H.-G.; Sluse-Goffart, C.; Sluse, Francis ULg

in Mathematical & Computer Modelling (1994), 19(6-8), 263-272

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See detailL'évaluation dans le domaine de l'éducation : tendances
de Landsheere, Gilbert ULg

in Orientation Scolaire et Professionnelle (L') [=OSP] (1994), 23(1), 59-77

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See detailStereoelectronic properties of five anti-HSV-1 2′-deoxynucleosides analogues with heterocyclic substituents in the 5-position: A comparison with BVDU
Olivier, Anne; Creuven, Isabelle; Evrard, Christine ULg et al

in Antiviral Research (1994), 24

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′ ... [more ▼]

Structural and electronic characteristics of 5-(5-chlorothien-2-yl)-2′-deoxyuridine (I), 5-(furan-2-yl)-2′-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2′-deoxyuridine (III), 5-(3-bromoisoxazol-5-yl)-2′-deoxyuridine (V) and 5-(isoxazol-5-yl)-2′-deoxyuridine (IV) have been determined and compared to the BVDU (VI) characteristics in order to explain their respective affinity for the herpes simplex virus type 1 thymidine kinase (TK). Molecular structure of 5-(5-chlorothien-2-yl)-2′-deoxyuridine has been obtained using single crystal X-ray crystallography. Electrostatic potential maps, energy and topology of frontier orbitals were computed at the ab initio MO STO-3G and STO-3G* level. These studies reveal that the electrostatic potential energy maps are clearly dependent on the affinity of the compound for the enzyme. [less ▲]

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See detailA thyroid hormone receptor-dependent glucocorticoid induction.
Leers, Joerg; Steiner, Christoff; Renkawitz, Rainer et al

in Molecular Endocrinology (Baltimore, Md.) (1994), 8(4), 440-7

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to ... [more ▼]

Glucocorticoid and thyroid hormones exert their effects in many body tissues by binding to their respective receptors. The search for possible cross-talking mechanisms in overlapping target cells led to the discovery of synergism between a thyroid hormone receptor-binding site and a cryptic glucocorticoid-responsive element. Glucocorticoid responsiveness could only be detected in the presence of thyroid hormone and its receptor. This synergism requires the glucocorticoid receptor (GR) DNA-binding domain and is mediated by the transactivation domains. We found that synergism also occurs when the thyroid hormone receptor is replaced by the retinoic acid receptor or the GR is replaced by the progesterone receptor. Synergism is qualitatively independent of the type of thyroid hormone receptor-binding site and promoter. In several combinations of promoter and response elements, including a retinoic acid response element, T3 induction was only seen in the presence of the cryptic glucocorticoid-responsive element, GR, and glucocorticoids. [less ▲]

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See detailIs aprotinin worth the risk in total hip replacement?
Janssens, Marc ULg; Joris, Jean ULg

in Anesthesiology (1994), 81(2), 518-519

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See detailStructure and orientation of apo B-100 peptides into a lipid bilayer.
Lins, Laurence ULg; Brasseur, Robert ULg; Rosseneu, M. et al

in Journal of Protein Chemistry (1994), 13(1), 77-88

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 ... [more ▼]

Peptides corresponding to lipid binding domains of Apo B-100 were synthesized, purified, and incubated with dimyristoylphosphatidylcholine (DMPC) liposomes. The secondary structure of the apo B-100 peptide-lipid complexes was evaluated by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Those peptides belonging to the hydrophobic "core" domain of apo B-100 when associated with phospholipids were rich in beta sheet structure; a predominant alpha helical conformation was shown to be associated with one peptide located in a surface region of apo B-100. IR dichroic spectra revealed, in the case of the "core" peptides, that the beta sheet component is the only oriented structure with respect to the phospholipid acyl chains. This orientation of the beta sheet was recently found in LDL particles after proteolytic digestion by trypsin (Goormaghtigh, E., Cabiaux, V., De Meutter, J., Rosseneu, M., and Ruysschaert, J. M., 1993, Biochemistry 32, 6104-6110). Altogether, the data suggest that beta sheet, present in a high proportion in the native apo B-100, is probably another protein structure in addition to the amphipathic helix which strongly interacts with the lipid outer layer surrounding the LDL particle. [less ▲]

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See detailNatural-Convection Above Line Heat-Sources In Greenhouse Canopies
Aubinet, Marc ULg; Deltour, Jules

in International Journal of Heat and Mass Transfer (1994), 37(12),

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See detailLes films Lumière : médiation symbolique et médiatisation
Servais, Christine ULg

in European Journal for Semiotic Studies = Revue Européenne d'Etudes Sémiotiques = Europäische Zeitschrift für Semiotische Studien (1994), 6(3-4), 505-538

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See detailSECULAR EVOLUTION OF THE VERTICAL COLUMN ABUNDANCES OF CHCLF2 (HCFC-22) IN THE EARTH'S ATMOSPHERE INFERRED FROM GROUND-BASED IR SOLAR OBSERVATIONS AT THE JUNGFRAUJOCH AND AT KITT-PEAK, AND COMPARISON WITH MODEL-CALCULATIONS
Zander, Rodolphe ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

in Journal of Atmospheric Chemistry (1994), 18(2), 129-148

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory ... [more ▼]

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory, Tucson, Arizona (U.S.A.), from 12/1980 to 04/1992, have been analyzed to provide a comprehensive ensemble of vertical column abundances of CHClF2 (HCFC-22; Freon-22) above the European and the North American continents. The columns were derived from nonlinear least-squares curve fittings between synthetic spectra and the observations containing the unresolved 2nu6 Q-branch absorption of CHClF2 at 829.05 cm-1. The changes versus time observed in these columns were modeled assuming both an exponential and a linear increase with time. The exponential rates of increase at one-sigma uncertainties were found equal to (7.0 +/- 0.35)%/yr for the Junfraujoch data and (7.0 +/- 0.23)%/yr for the Kitt Peak data. The exponential trend of 7.0%/yr found at both stations widely separated in location can be considered as representative of the global increase of the CHClF2 burden in the Earth's atmosphere during the period 1980 to 1992. When assuming two realistic vertical volume mixing ratio profiles for CHClF2 in the troposphere, one quasi constant and the other decreasing by about 13% from the ground to the tropopause, the concentrations for mid-1990 were found to lie between 97 and 111 pptv (parts per trillion by volume) at the 3.58 km altitude of the Jungfraujoch and between .97 and 103 pptv at Kitt Peak, 2.09 km above sea level. Corresponding values derived from calculations using a high vertical resolution-2D model and recently compiled HCFC-22 releases to the atmosphere, were equal to 107 and 105 pptv, respectively, in excellent agreement with the measurements. The model calculated lifetime of CHClF2 was found equal to 15.6 years. The present results are compared critically with similar data found in the literature. On average, the concentrations found here are lower by 15-20% than those derived from in situ investigations; this difference cannot be explained by the absolute uncertainty of +/- 11% assigned presently to the infrared remote measurements. [less ▲]

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See detailMeningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient
Snoeck, R.; Gérard, M.; Sadzot-Delvaux, Catherine ULg et al

in Journal of Medical Virology (1994), 42(4), 338-347

Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in ... [more ▼]

Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in an AIDS patient, associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)-deficient, acyclovir (ACV)-resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 9-beta-D-arabinofuranosyladenine (vidarabine), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV-resistant VZV infections in immunocompromised patients. (C) 1994 Wiley-Liss, Inc. [less ▲]

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See detailA semiautomated test apparatus for studying partner preference behavior in the rat.
Bakker, Julie ULg; van Ophemert, J.; Eijskoot, F. et al

in Physiology & Behavior (1994), 56(3), 597-601

A semiautomated three-compartment box (3CB) for studying partner preference behavior of rats is described. This apparatus automatically records the rat's time spent in each compartment, as well as the ... [more ▼]

A semiautomated three-compartment box (3CB) for studying partner preference behavior of rats is described. This apparatus automatically records the rat's time spent in each compartment, as well as the locomotor activity (i.e., the number of visits an animal pays to each compartment). Software was developed for calculating partner preference scores. Behavioral testing in the semiautomated 3CB, which is a modification of an earlier version, is less time consuming and less laborious. Three 3CBs can be observed simultaneously by two trained observers, and the behavioral interactions of three experimental animals with the stimulus animals can be observed and scored by hand. The use of the new apparatus was validated by studying adult partner preference behavior of neonatally ATD-treated male rats. The collected data fully corroborate previous results, obtained in the earlier version of the 3CB, again revealing the behavioral bisexual nature of these ATD males. A new finding was the much higher locomotor activity of the ATD males compared to controls. [less ▲]

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See detailComparaison de l'évolution de 2 litières biomaîtrisées à base de sciure ou de paille pour porcs à l'engraissement
Marlier, Didier ULg; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1994), 138(1), 45-53

Two rooms of a pig house were used to study 2 deep litter systems where the animals were kept on a 50 cm thick layer of sawdust or of chopped straw (10 cm). Seven days before the arrival of the animals ... [more ▼]

Two rooms of a pig house were used to study 2 deep litter systems where the animals were kept on a 50 cm thick layer of sawdust or of chopped straw (10 cm). Seven days before the arrival of the animals, slurry and a microbial product used to stimulate the fermentation were added to the litters. Fifteen pigs on sawdust and seventien pigs on straw (floor spaces : 1.4 and 1.2 M2/pig) were fattened from 23.1 to 93.1 kg live weight. Excreta from pigs was dung into the bedding weekly and treated with the microbial product. This labour was considered as too hard in the straw room and was ended at day 105. No sawdust was added during the fattening period but straw was added 5 times to keep the pigs clean and to keep the temperature in the bedding higher than 30-degrees-C. The mean temperature in the sawdust bed was higher (38 +/- 5,4-degrees-C vs 35 +/- 6,7-degrees-C, p > 0,001) and more constant (mean daily variation 1,3 +/- 1,6 vs 2,2 +/- 2,4-degrees-C, p > 0,001) than the temperature recorded in the straw bed. The air temperature and the relative humidity were similar in the 2 rooms (21-degrees-C and 60 The concentrations of ammonia in the air were measured with Gastec tubes. The average ammonia concentrations recorded during the 7 days before the arrival of the animals (48 +/- 36 ppm vs 12 +/- 9,2 ppm) and those recorded after the eighth day (11 +/- 5,6 ppm vs 6,7 +/- 3,9 ppm) were significantly higher with the straw system compared with the sawdust system. The daily gains were not significantly different in the 2 rooms (552 g on average) and the food conversion ratios in the 2 rooms were 3,6 kg/kg (on sawdust) and 3,85 kg/kg (on straw). Carcasses were of equal quality. In conclusion, results were better with the sawdust bed than with the straw bed. The sawdust bed provided a higher temperature in the bedding and a lower ammonia concentration in the air. The routine weekly task of digging was easier in the sawdust bed and the bedding was used for a second batch. [less ▲]

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See detailBGU III 897 et PSI XII 1228: συγγραφαί notariées publiques?
Straus, Jean ULg

in Zeitschrift für Papyrologie und Epigraphik (1994), 104

Le BGU III 987 = M. Chr. 269 est certainement une suggraphe notariée publique et le PSI XII 1228 en est vraisemblablement une, même s'il présente un élément constitutif importun.

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See detailAutonomously functioning thyroid nodules in a patient with a thyrotropin-secreting pituitary adenoma: possible cause--effect relationship.
Abs, R.; Stevenaert, Achille ULg; Beckers, Albert ULg

in European Journal of Endocrinology (1994), 131(4), 355-8

A 51-year-old female patient with long-standing hyperthyroidism due to a thyrotropin-secreting pituitary adenoma is reported, who became thyrotoxic again shortly after successful pituitary surgery ... [more ▼]

A 51-year-old female patient with long-standing hyperthyroidism due to a thyrotropin-secreting pituitary adenoma is reported, who became thyrotoxic again shortly after successful pituitary surgery. Functional testing and scintigraphy suggested the diagnosis of autonomous functioning thyroid nodules, which was confirmed by pathological examination of the resected thyroid tissue. This is the first report revealing the transition from a pituitary-dependent to a thyroid-dependent hyperthyroidism. Autonomous functioning thyroid nodules are, however, considered an intrinsic thyroid defect. In similarity with other disorders, in which trophic hormones may induce an autonomous secretion by the target gland, this report opens the possibility that a humoral factor may play a role in the development of autonomous functioning thyroid nodules. [less ▲]

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See detailDe l'école à l'entreprise ou le processus d esocialisation mis en échec
Robert, Jocelyne ULg

in Eucation-Formation (1994)

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See detailPropriétés antifongiques de la microflore sporulée du netetu.
N'dir, B.; Hbid, Ch.; Cornelius, C. et al

in Cahiers Agricultures (1994), 3

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See detailProtection du vendeur : les garanties légales et conventionnelles
Gosselin, Antoinette ULg

in Actualités du Droit (1994), (4), 933-972

The contribution envisages the protection of the seller as part of the cession of a firm in return for remuneration, giving rise to the payment of a price in exchange for the transfer of ownership. Sale ... [more ▼]

The contribution envisages the protection of the seller as part of the cession of a firm in return for remuneration, giving rise to the payment of a price in exchange for the transfer of ownership. Sale can concern a business or a number of actions or parts representative of an important party of the capital allowing to acquire the control of the society. The first party examines the lawful protection of the giving up, the second conventional guarantees in which giving it up can think to protect itself against the nonpayment of price by the seller. [less ▲]

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See detailA REMARKABLE AURORAL EVENT ON JUPITER OBSERVED IN THE ULTRAVIOLET WITH THE HUBBLE-SPACE-TELESCOPE
Gérard, Jean-Claude ULg; Grodent, Denis ULg; Prangé, R. et al

in Science (1994), 266(5191), 1675-1678

Two sets of ultraviolet images of the Jovian north aurora were obtained with the Faint Object Camera on board the Hubble Space Telescope. The first series shows an intense discrete are in near corotation ... [more ▼]

Two sets of ultraviolet images of the Jovian north aurora were obtained with the Faint Object Camera on board the Hubble Space Telescope. The first series shows an intense discrete are in near corotation with the planet. The maximum apparent molecular hydrogen emission rate corresponds to an electron precipitation of similar to 1 watt per square meter, which is about 30,000 times larger than the solar heating by extreme ultraviolet radiation. Such a particle heating rate of the auroral upper atmosphere of Jupiter should cause a large transient temperature increase and generate strong thermospheric winds. Twenty hours after initial observation, the discrete are had decreased in brightness by more than one order of magnitude. The time scale and magnitude of the change in the ultraviolet aurora leads us to suggest that the discrete Jovian auroral precipitation is related to large-scale variations in the current system, as is the case for Earth's discrete aurorae. [less ▲]

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See detailFirst-principles calculations of dielectric and effective charge tensors in Barium Titanate
Ghosez, Philippe ULg; Gonze, X.; Michenaud, J. P.

in Ferroelectrics (1994), 153

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See detailEctopie cervicale du coeur chez un veau
Gabriel, Annick ULg; Vandeputte, Sébastien ULg; Rollin, Frédéric ULg et al

in Annales de Médecine Vétérinaire (1994), 138

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See detailHigh-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
Janssens, Marc ULg; Joris, Jean ULg; David, Jean-Louis et al

in Anesthesiology (1994), 80

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See detailEvaluation of agents used in osteoporosis: What are the needs ?
Reginster, Jean-Yves ULg

in Osteoporosis Japan (1994), 2

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See detailInsulin secretion, clearance and action before and after gastroplasty in severely obese subjects.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1994), 18(5), 295-300

This study investigated the effects of a drastic weight reduction on insulin secretion rate (ISR), insulin metabolic clearance rate (MCRI) and insulin sensitivity (SI) in severely obese subjects. A ... [more ▼]

This study investigated the effects of a drastic weight reduction on insulin secretion rate (ISR), insulin metabolic clearance rate (MCRI) and insulin sensitivity (SI) in severely obese subjects. A frequently sampled intravenous glucose tolerance test (FSIVGTT, 0.3 g/kg) was performed before and 8 +/- 1 months after a vertical ring gastroplasty in 12 overnight-fasted obese non-diabetic subjects; the results were compared to those obtained in 12 lean controls matched for age and sex. ISR was derived by deconvolution of plasma C-peptide levels; MCRI was obtained by dividing the area under the curve (AUC180 min) of ISR by the corresponding AUC of plasma insulin levels (IRI); the SI and the glucose effectiveness index (SG) were calculated by Bergman's minimal model. Before gastroplasty, obese subjects showed significantly higher ISR (P < 0.02), lower MCRI (P < 0.001), lower SI (P < 0.001) but similar SG when compared to lean controls. After gastroplasty (reduction of body weight from 104.8 +/- 3.8 to 73.4 +/- 3.6 kg and of BMI from 37.9 +/- 0.8 to 26.5 +/- 0.9 kg/m2; P < 0.001), ISR only decreased from 53,125 +/- 7968 to 42,302 +/- 3716 pmol/180 min (not significant) while AUC-IRI dramatically fell from 53,626 +/- 6378 to 21,111 +/- 2584 pmol.min/l; P < 0.001); consequently, MCRI markedly increased from 526 +/- 96 to 1257 +/- 150 ml/min/m2; P < 0.01). SI significantly rose from 3.12 +/- 0.45 to 7.10 +/- 1.20 x 10(-4) l/mU/min (P < 0.005) while SG remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailDesign and modeling of new PAF antagonists - 1,4-bis-(3',4',5'-trimethoxybenzoyl)-2-substituted carbonyloxymethyl piperazines
Heymans, Françoise; Lamouri, Aazdine; Batt, Jean-Pierre et al

in Journal of Lipid Mediators and Cell Signalling (1994), 10(1-2), 153-154

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See detailPathogenesis of migraine: the biobehavioural and hypoxia theories reconciled.
Schoenen, Jean ULg

in Acta Neurologica Belgica (1994), 94(2), 79-86

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino ... [more ▼]

The recent pathophysiological data obtained in migraine patients during and between attacks are reviewed in this article. They suggest that the headache in migraine is due to activation of the trigemino-vascular system. While this can be found in other headache disorders, the process leading ultimately to trigemino-vascular activation appears to characterize migraine. Between attacks, the migrainous brain has two functional abnormalities: a habituation defect in sensory processing, probably related to dysfunctioning transmitter (serotonin, noradrenaline) systems and a reduced mitochondrial energy reserve. Both abnormalities may be genetically determined and concur to favour biochemical shifts leading to the migraine attack as a primary protective mechanism of the brain. Such a model of migraine pathogenesis reconciles the biobehavioural and hypoxia theories and opens new therapeutic perspectives. [less ▲]

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See detailCommon Prevalence Of Alanine And Glycine In Mobile Reactive Center Loops Of Serpins And Viral Fusion Peptides - Do Prions Possess A Fusion Peptide
Callebaut, I.; Tasso, A.; Brasseur, Robert ULg et al

in Journal of Computer-Aided Molecular Design (1994), 8(2),

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by ... [more ▼]

Serpin reactive centre loops and fusion peptides released by proteolytic cleavage are particularly mobile. Their amino acid compositions reveal a common and unusual abundance of alanine, accompanied by high levels of glycine. These two small residues, which are not simultaneously abundant in stable helices (standard or transmembrane), probably play an important role in mobility. Threonine and valine (also relatively small amino acids) are also abundant in these two kinds of peptides. Moreover, the known 3D structures of an uncleaved serpin reactive centre and a fusion peptide are strikingly similar. Such sequences possess many small residues and are found in several signal peptides and in PrP, a protein associated with spongiform encephalopathies and resembling virus envelope proteins. These properties may be related to the infection mechanisms of these diseases. [less ▲]

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See detailOù peut-on planter l’aulne glutineux avec succès ?
Claessens, Hugues ULg

in Silva Belgica (1994), 101

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See detailA fuzzy approach to the definition of standardized visibility in fog.
Boreux, Jean-Jacques ULg; Duckstein, Lucien

in Applied Mathematics and Computation (1994), 61(2-3), 287-299

The problem of defining the physical concept of standardized visibility is addressed by means of a fuzzy logic approach. Assuming that several hypotheses hold, it is possible to evaluate a standardized ... [more ▼]

The problem of defining the physical concept of standardized visibility is addressed by means of a fuzzy logic approach. Assuming that several hypotheses hold, it is possible to evaluate a standardized visibility Vk (or meteorological visual range) as the ratio of a psychometric coefficient k and the extinction coefficient σ of the aerosol. The main disadvantage of this relationship due to Koschmieder stems from the fact that the meteorological visual range can be very different from visibility estimated by a human observer with normal sight. This is particularly true during fog extinction coefficient supplied by a transmissometer and the corresponding visibility evaluated by an expert. Calculations are performed according to two different approaches. First, a so-called fuzzy hyperbolic model based on a distance defined by Bardossy et al is presented, yielding a crisp (nonfuzzy) value of the coefficient k. Next, we use the multiplication of two fuzzy numbers, taken as triangular, to build an average fuzzy number k that accounts for the different values found in the literature. The defuzzification of k confirms the result obtained by the first approach. [less ▲]

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See detailComparative performance study of postal services: a productive efficiency approach
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Annales d'Economie et de Statistique (1994), (33), 187-202

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It ... [more ▼]

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It then presents an empirical efficiency study of postal services which is aimed at comparing productive performance indicators across countries and at testing the effect of competition and regulation on these indicators. [less ▲]

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See detailDie monofrequente Oszilloresistometrie - Möglichkeiten und Grenzen eines nichtinvasiven Verfahrens zur Atemwiderstandsmessung beim Kalb
Reinhold, Petra; Close, Roland; Lekeux, Pierre ULg

in Deutsche Tierarztliche Wochenschrift (1994), 101(4), 146-150

The monofrequency forced oscillation technique (MFOT) has been found to be a simple, reproducible, fast and accurate method to carry out lung function testing in calves even under field conditions. If ... [more ▼]

The monofrequency forced oscillation technique (MFOT) has been found to be a simple, reproducible, fast and accurate method to carry out lung function testing in calves even under field conditions. If some technical as well as methodological requirements are taken into account, pulmonary or respiratory resistance can be assessed by means of the parameter oscillatory resistance (Ros). Furthermore, several Ros derived parameters are available for describing the functional status of the central bronchial system. Due to the low variability caused by methodological or intraindividual reasons, the MFOT represents a very qualified method for intraindividual studies. Comparing measuring results of different subjects, a higher biologically caused variance has to be taken into account. [less ▲]

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See detailSpecific inhibition of expression of a human collagen gene (COL1A1) with modified antisense oligonucleotides. The most effective target sites are clustered in double-stranded regions of the predicted secondary structure for the mRNA.
Laptev, A. V.; Lu, Z.; Colige, Alain ULg et al

in Biochemistry (1994), 33(36), 11033-9

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system ... [more ▼]

A series of antisense oligonucleotides (ASOs) were synthesized and tested to define the best target sites within an RNA transcript of collagen for effective inhibition of expression. The test system consisted of mouse NIH 3T3 fibroblasts that were stably transfected with a human minigene for procollagen I so that the cells simultaneously synthesized full-length mouse pro alpha 1 (I) chains and internally deleted human pro alpha 1 (I) chains. The sequences of the transcripts from both genes were compared, and a series of 28 ASOs were designed to target sites in which there were at least two base differences within a 20-nucleotide sequence between the human and mouse transcripts. Six of the ASOs specifically decreased the levels of pro alpha 1 (I) chain synthesized from the human gene without a decrease in the levels of pro alpha 1 (I) chains from the mouse endogenous gene. The most effective ASOs reduced the intracellular levels of human pro alpha 1 (I) chains relative to the mouse pro alpha 1 (I) chains to 37-67% of the control values. Combined addition of two effective ASOs or a second administration of the same effective ASO did not produce any additive effect. The results did not support previous suggestions that the best target sites for ASOs were sequences around initiation codons for translation, at intron-exon boundaries, or in single-stranded loops in hairpin structures. Also, the results did not support previous suggestions that the most effective ASOs are those with the highest affinities for their target sequences. Instead, the most consistent pattern in the data was that the most effective ASOs were those targeted to sequences that were predicted to form clustered double-stranded structures in RNA transcripts. [less ▲]

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See detailModèles de cubage pour essences multi-tiges: application à des plantations d'acacia.
Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Cahiers Agricultures (1994), 3(3),

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une ... [more ▼]

Des tarifs de cubage individuels ont été construits pour estimer le volume de plantations d'Acacia auriculiformis A. Cunn. ex Benth destinées à la production de bois de feu. Ces tarifs fournissent, d'une part, le volume total incluant le bois de tiges et de branches jusqu'à une découpe de 9 cm de circonférence et, d'autre part, ce volume réparti en classes de circonférences de 9 à 14 cm, 15 à 44 cm et plus de 45 cm. Cette essence est généralement abondamment ramifiée, ce qui complique la détermination de son volume et interfère avec la caractérisation d'une variable dendrométrique déterminante, à savoir la circonférence ou le diamètre à 1,30m au-dessus du niveau du sol. Lorsque plusieurs tiges sont observées à 1,30m de hauteur, il est proposé de considérer une circonférence théorique résultant de la somme quadratique des circonférences des brins mesurés à ce niveau. Différentes équations de cubage mettant en oeuvre les circonférences à la base de l'arbre (niveau d'abattage) ou à 1,30m, ainsi que la hauteur totale, l'âge et le nombre de brins, sont proposées pour des plantations âgées de quelques dizaines de mois. En termes de compromis entre précision des estimations et coût des mesures, l'équation faisant intervenir la circonférence à 1,30m, l'âge et le nombre de brins s'est avérée la plus satisfaisante. En ce qui concerne les estimations de volume par assortiments, applicables à des plantations plus âgées, les équations ne faisant intervenir que la seule circonférence à 1,3m sont largement acceptables. [less ▲]

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See detailON THE FUNCTIONAL-CHARACTERIZATION OF THE ANALYTIC WAVE-FRONT SET OF AN HYPERFUNCTION
Bastin, Françoise ULg; LAUBIN, P.

in Mathematische Nachrichten (1994), 166

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See detailThiamine in Excitable Tissues: Reflections on a Non-Cofactor Role
Bettendorff, Lucien ULg

in Metabolic Brain Disease (1994), 9(3), 183-209

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See detailCircadian rhythms and the induction of flowering in the long-day grass Lolium temulentum L.
Périlleux, Claire ULg; Bernier, Georges ULg; Kinet, Jean Marie

in Plant, Cell & Environment (1994), 17(6), 755-761

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For ... [more ▼]

Plants of Lolium temulentum L. strain Ceres were grown in 8-h short day (SD) for 45 d before being exposed either to a single long day (LD) or to a single 8-h SD given during an extended dark period. For LD induction, the critical photoperiod was between 12 and 14 h, and more than 16 h were needed for a maximal flowering response. During exposure to a single 24-h LD, the translocation of the floral stimulus began between the fourteenth and the sixteenth hours after the start of the light period, and was completed by the twenty-fourth hour. Full flowering was also induced by one 8-h SD beginning 4 or 28 h after the start of a 40-h dark period, i.e. by shifting 12 h forward or beyond the usual SD. The effectiveness of a so-called 'displaced short day' (DSD) was not affected by light quality and light intensity. With a mixture of incandescent and fluorescent lights at a total photosynthetic photon flux density of 400 µmol m-2 s-1, a 4-h light exposure beginning 4 h after the start of a 40-h dark period was sufficient to induce 100 flowering. The flower-inducing effect of a single 8-h DSD was also assessed during a 64-h dark period. Results revealed two maxima at a 20-h interval. This fluctuation in light sensitivity suggests that a circadian rhythm is involved in the control of flowering of L. temulentum. [less ▲]

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See detailL'hyperthermie, une modalité oncologique pluridisciplinaire
Coucke, Philippe ULg; GUILLEMIN; RAIMONDI et al

in Médecine et Hygiène (1994), 52(2037), 1720-1722

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une ... [more ▼]

L-hyperthermie consiste en l'élévation de la température du corps ou d'une de ses parties, par des moyens externes au-delà de 41°C. La chaleur a une activité cytotoxique propre et provoque une sensibilisation des cellules aux radiations ionisantes ou à la chimiothérapie. Le gain thérapeutique est environ de 2. Seules les tumeurs superficielles peuvent être traitées adéquatement par les moyens actuels. Les indications sont la palliation de tumeurs superficielles telles que les récidives loco-régionales du cancer du sein, les récidives ganglionnaires de cancers ORL et les cancers de la peau, en particulier les mélanomes [less ▲]

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See detailDifferential diagnosis of Alzheimer's disease with PET.
Salmon, Eric ULg; Sadzot, Bernard ULg; Maquet, Pierre ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1994), 35(3), 391-8

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias ... [more ▼]

PET studies have demonstrated bilateral temporo-parietal hypoperfusion and hypometabolism in probable and definite Alzheimer's disease (AD), a pattern that may help differentiate AD from other dementias. METHODS: To evaluate the diagnostic power of cerebral metabolic distribution patterns for "cortical" degenerative dementias, PET scans obtained from 129 patients referred for differential diagnosis of dementia were analyzed visually. RESULTS: Sixty-five patients had a final clinical diagnosis of probable AD. Ninety-seven percent (97%) of those had abnormal metabolic scans and 94% showed a suggestive pattern of bilateral or unilateral temporo-parietal hypometabolism (with or without frontal involvement). Hypometabolism was unilateral in 23% of patients. Five subjects with a neuropathologically proven diagnosis of Alzheimer's disease had a suggestive metabolic pattern. One of those was an early case with frontal hypometabolism exceeding temporo-parietal involvement. Two patients with Alzheimer's-type dementia had isolated bilateral frontal hypometabolism. CONCLUSIONS: This alternative metabolic pattern may correspond to a non-Alzheimer pathology occurring in 10%-20% of patients suffering from clinically probable Alzheimer's disease. Most of the patients with possible but atypical Alzheimer's-type dementia showed isolated bilateral frontal involvement. This metabolic pattern probably corresponds to different diseases, such as Pick's disease, frontal lobe dementia or progressive subcortical gliosis. [less ▲]

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See detailModulation of the acetylcholine- and substance P-induced pulmonary edema by calcitonin gene-related peptide in the rabbit.
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Journal of Pharmacology and Experimental Therapeutics (The) (1994), 270(1), 30-6

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the ... [more ▼]

The effects of calcitonin gene-related peptide (CGRP) (6 x 10(-8) M) on hemodynamics and on pulmonary microvascular permeability were investigated in isolated, perfused rabbit lungs by measuring the arterial, capillary and venous pressures and the capillary filtration coefficient (Kf,c). CGRP was administered alone or in combination with capsaicin (10(-4) M), acetylcholine (ACh) (10(-11) M to 10(-7) M), substance P (SP) (10(-10) M to 10(-6) M) and serotonin (10(-4) M). The influence of a specific antagonist of CGRP receptors, CGRP8-37 (10(-8) M), on the pulmonary edema induced by these mediators was also considered. CGRP had no direct effect on the vascular pressures or on Kf,c. Capsaicin and serotonin induced an increase in Kf,c of 271 +/- 49% and 676 +/- 147% of base line, respectively. ACh and SP also increased the microvascular permeability, in proportion to the concentration. The effects of capsaicin, ACh and SP have been related to the activation of neurokinin NK1 receptors. Co-administration of CGRP with capsaicin and ACh enhanced the increase in Kf,c induced by these two drugs. By contrast, when co-injected with SP, CGRP inhibited the Kf,c increase induced by 10(-8) M and 10(-7) M of SP (P < .05) and significantly decreased the arterial and capillary pressures. CGRP also partly prevented the pulmonary edema induced by serotonin (P < .05). Pretreatment with CGRP8-37 partly prevented the effects of capsaicin and ACh on Kf,c but bestowed no protection against SP-induced pulmonary edema. These data suggest that CGRP is co-released with SP from the C-fibers upon the action of capsaicin and ACh in the rabbit lung. Because CGRP potentiated the pulmonary edema induced in capsaicin and ACh, but decreased the effects of SP, we hypothesize that CGRP exerts a positive retro-control on the release of neuropeptides by these fibers but can attenuate their effects on the target cells. [less ▲]

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See detailLe prix de la vie: une approche ex post
Faudemer, S.; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Risques (1994), (19), 117-132

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See detailLa responsabilité délictuelle des communes
Lewalle, Paul ULg; Dressen, Cécile; Durviaux, Ann-Lawrence ULg

in Revue de Droit Communal (1994)

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See detailCerebral blood flow velocities during natural bovine surfactant therapy in very preterm babies
Battisti, Oreste ULg; Detry, J.; Louis, J. et al

in Circulation et Métabolisme du Cerveau (1994), 11

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See detailL'identité wallonne saisie par l'enquête : une approche constructiviste de l'identité collective
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1994), 26

The paper shows how a constructivist approach of collective identity makes sense of the use of survey data to approach regional walloon identity

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See detailEtude multicentrique du dosage de la transferrine déficiente en acide sialique par deux techniques chromatographiques
Vernet, M.; Renversez, J. C.; Revenant, M. C. et al

in Annales de Biologie Clinique (1994), 52

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See detailEpidemiology of insulin resistance and hypertension in adults - MONICA BELLUX- preliminary results.
Saint-Remy, Annie ULg; Beck, Dominique; Lefèbvre, Pierre ULg et al

in Cardiovascular Disease Epidemiology Newsletter, Amercian Heart Association (1994), 49

Numerous publications have outlined that insulin resistance, hypertension and obesity are often associated suggesting a common link in the pathogenic mechanisms.

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See detailL'autisme et la pensée du temps
Gauthier, Jean-Marie ULg

in Recherches du centre international de psychosomatique (1994), 1

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See detailGelatinase A expression and localization in human breast cancers. An in situ hybridization study and immunohistochemical detection using confocal microscopy.
Polette, M.; Gilbert, N.; Stas, I. et al

in Virchows Archiv : An International Journal of Pathology (1994), 424

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is ... [more ▼]

The gelatinase A (72 kDa type IV collagenase) is a matrix metallo-proteinase which degrades basement membrane collagens. Various studies emphasize its role in stromal invasion of cancers, but there is some controversy about its origin. Gelatinase A was localized by immunohistochemistry using confocal microscopy in 15 human mammary carcinomas. In addition, the cells responsible for the synthesis of this enzyme were detected by in situ hybridization. Most invasive and non-invasive tumour cells were labelled by immunohistochemistry. Of particular interest was the pattern observed in some pre-invasive areas. Gelatinase A was found in fibroblasts in close contact with pre-invasive tumour clusters. Confocal observation allowed a more precise localization of gelatinase A to the periphery of tumour clusters along the basement membranes and in peritumour fibroblasts. The malignant epithelial cells were negative by immunohistochemistry in these areas. By in situ hybridization, mRNAs encoding gelatinase A were detected only in fibroblasts in close contact with pre-invasive and well differentiated tumour clusters. These findings support the hypothesis that peritumour fibroblasts produce gelatinase A and that breast cancer cells may bind this enzyme to their cell surface and/or internalize it. [less ▲]

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See detailValeur semeiologique des examens de laboratoire: application multicentrique au depistage des metastases hepatiques.
Bourguignat, Alain; Albert, Adelin ULg; Dumont, Gilles et al

in Annales de Biologie Clinique (1994), 52(11), 787-97

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See detailFavoriser la reproduction des poissons à Lanaye.
Poncin, Pascal ULg; Keulen, C.

in Pêcheur Belge (Le) (1994), 6

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See detailANOMALOUS PERTURBATIVE TRANSPORT IN TOKAMAKS DUE TO DRIFT-WAVE TURBULENCE
Thoul, Anne ULg; SIMILON, P. L.; SUDAN, R. N.

in Physics of Plasmas (1994), 1(3), 579-600

A new method for calculating the anomalous transport in tokamak plasmas is presented. The renormalized nonlinear plasma response function is derived using the direct-interaction approximation (DIA). A ... [more ▼]

A new method for calculating the anomalous transport in tokamak plasmas is presented. The renormalized nonlinear plasma response function is derived using the direct-interaction approximation (DIA). A complete calculation for the case of electrostatic drift-wave turbulence is presented. Explicit expressions for all coefficients of the anomalous transport matrix relating particle and heat fluxes to density and temperature gradients in the plasma are obtained. The anomalous transport matrix calculated using the DIA does not have the Onsager symmetry. As an example of application, the parameters of the Texas Experimental Tokamak (TEXT) [Nucl. Technol. Fusion 1, 479 (1981)] are used to evaluate all transport coefficients numerically, as well as the spectrum modulation. The relation between the theoretical results and the experimental data is discussed. Although this paper focuses on electron transport for simplicity, the method can also be used to calculate anomalous transport due to ion instabilities, such as the ion-temperature-gradient instability. [less ▲]

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See detailBehavioural study of hybridization between Barbus barbus and Barbus meridionalis
Poncin, Pascal ULg; Jeandarme, J.; Berrebi, P.

in Journal of Fish Biology (1994), 45

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See detailLe Monitoring de la pression artérielle en pratique médicale : apports et limites
Saint-Remy, Annie ULg; Rorive, Georges ULg

in Blood Pressure Profil (1994), 3

"L'article de Mme Saint-Remy et de G. Rorive constitue une bonne mise au point sur les controverses qui continuent à se développer autour de la place à réserver au monitorage ambulatoire de la pression ... [more ▼]

"L'article de Mme Saint-Remy et de G. Rorive constitue une bonne mise au point sur les controverses qui continuent à se développer autour de la place à réserver au monitorage ambulatoire de la pression artérielle (MAPA) dans l'évaluation du patient hypertendu. La variabilité importante universellement admise de la pression artérielle rend le concept du monitorage pendant 24 heures particulièrement attrayant. L'utilité de cette nouvelle approche ne sera cependant définitivement établie que quand les résultats d'études prospectives visant à démontrer la supériorité du MAPA sur la mesure conventionnelle de la pression artérielle seront connus. Deux études sont au minimum actuellement en cours en ce sens : l'étude OVA et l'étude Systeur. En attendant, le manque de valeurs normatives est évidemment un handicap pour l'intérêt de la MAPA dans la pratique journalière et ce d'autant plus que le coût de cette nouvelle méthodologie reste élevé. Dans la revue de la littérature de ce numéro de Blood Pressure Profile, deux publications viennent confirmer ce qui est avancé dans l'article de Mme Saint-Remy. Bianchi et col, observant que la microalbuminurie est plus importante chez les hypertendus en l'absence de chute nocturne de la pression artérielle, argumentent en faveur du rôle de la MAPA dans l'évaluation du pronostic cardio-vasculaire du patient hypertendu. De plus, Mansoor et al, confirmant la meilleure reproductibilité de MAPA par rapport à la mesure conventionnelle de la pression artérielle, concluent également que la MAPA permettra de diminuer le nombre de patients à inclure dans des essais de pharmacologie clinique. Ces résultats, bien qu'encourageant pour les défenseurs du MAPA, ne doivent cependant pas nous faire oublier que la généralisation de l'utilisation de cette nouvelle technique est à l'heure actuelle prématurée" Prof. J.P. Degaute, Hypertension Clinic, Hôpital Universitaire Erasme, Chief Editor [less ▲]

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See detailT-CELLS SKIN LYMPHOMA IN 3 DOGS
Gilbert, S.; Clercx, Cécile ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1994), 138(8), 587-595

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See detailMachine learning, neural networks and statistical pattern recognition for voltage security: a comparative study
Wehenkel, Louis ULg; Van Cutsem, Thierry ULg; Pavella, Mania ULg et al

in International Journal of Intelligent Systems (1994), 2

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See detailLes dommages dus aux plans et leur indemnisation dans le cadre du CWATUP
Delnoy, Michel ULg

in Aménagement - Environnement (1994), 3

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See detailA new species of trametes from Papua New Guinea
Castillo Cabello, Gabriel ULg

in Mycotaxon (1994)

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East ... [more ▼]

Trametes demoulinii from Papua New guinea is descrebed as new. The new taxon is closest to Trametes conchifer and Trametes membranacea, both from America and Trametes cingulata know in Africa and East Asia. In addition to basidiomata, cultural characters of the new species are described. [less ▲]

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See detailLes souches attachantes et effaçantes d'Escherichia coli d'origine bovine
Mainil, Jacques ULg; Pohl, P.

in Annales de Médecine Vétérinaire (1994), 138

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See detailPlasmids for heavy metal resistance in Alcaligenes eutrophus CH34: Mechanisms and applications
Collard, Jean-Marc; Corbisier, Philippe; Diels, Ludo et al

in FEMS Microbiology Reviews (1994), 14

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy ... [more ▼]

Alcaligenes eutrophus CH34 is the main representative of a group of strongly related strains (mostly facultative chemolithotrophs) that are well adapted to environments containing high levels of heavy metals. It harbors the megaplasmids pMOL28 and pMOL30 which carry resistance determinants to Co2+, Ni2+, CrO42-, Hg2+, Tl+, Cd2+, Cu2+ and Zn2+. Among the best characterized determinants are the cnr operon (resistance to Co, Ni) an pMOL28 and the czc operon on pMOL30 (resistance to Co, Cd and Zn). Although the two systems reveal a significant degree of amino acid similarity in the structural genes, the regulation of the operons is different. The resistance mechanism in both cases is based on efflux. The efflux mechanism leads to a pH increase outside of the cytoplasmic membrane. Metals are sequestered from the external medium through the bioprecipitation of metal carbonates formed in the saturated zone around the cell. This latter phenomenon can be exploited in bioreactors designed to remove metals from effluents. The bacteria are immobilized on composite membranes in a continuous tubular membrane reactor (CTMR). The effluent continuously circulates through the intertubular space, while the external surface of the tubes is in contact with the growth medium. Metal crystals are eventually removed by the effluent stream and collected on a glass bead column. The system has been applied to effluents containing Cd, Zn, Co, Ni and Cu. By introducing catabolic plasmids involved in the aerobic degradation of PCBs and 2,4-D into metal-resistant A. eutrophus strains, the application range was widened to include effluents polluted with both organic and inorganic substances. Biosensors have been developed which are based on the fusion of genes induced by metals to a reporter system, the lux operon of Vibrio fischeri. Bacterial luciferases produce light through the oxidation of fatty aldehydes. The gene fusions are useful both for the study of regulatory genes and for the determination of heavy metal concentrations in the environment. [less ▲]

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See detailPrésentation des activités du Laboratoire SURFACES de l'Université de Liège
Donnay, Jean-Paul ULg

in S.I.G. & Télédétection (1994), 12

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See detailAssessment of the new immunological test Hemoblot for detecting occult blood in faeces
Jeanson, Antoinette; Jamart, J.; Maisin, J. M. et al

in European Journal of Cancer Prevention (1994), 3(5), 407-412

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and ... [more ▼]

Hemoblot, a new immunological faecal occult blood test, produced by Gamma, Angleur, Belgium, was characterized and compared with another immunological test (HemeSelect, SmithKline Diagnostics, USA) and with a guaiac test (Hemoccult II, SmithKline Diagnostics). The analytical sensitivity of Hemoblot is 0.15 mg haemoglobin/g faeces and the test is specific for human haemoglobin. In addition, 135 symptomatic patients who had to undergo a colonoscopy were tested using the three tests. Two criteria were considered for the analysis: (1) the blood criterion: any pathology likely to cause colorectal or other bleeding; and (2) the precancerous-cancerous criterion: the pathology being either a colorectal polyp > 0.5 cm or a colorectal cancer. Considering both criteria, the sensitivity of Hemoblot was significantly higher than the sensitivity of Hemoccult: 38% and 23%, respectively, for the blood criterion; and 54% and 29% for the precancerous-cancerous criterion. Sensitivity and specificity did not differ statistically between Hemoblot and HemeSelect but Hemoblot was faster and simpler to perform. It could be widely used in mass screening. [less ▲]

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See detailDirect n.m.r. evidence for substrate-induced conformational changes in a beta-lactamase.
Jamin, M.; Damblon, Christian ULg; Bauduin-Misselyn, A. M. et al

in Biochemical Journal (1994), 301 ( Pt 1)

Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very poor substrates of the Bacillus licheniformis beta-lactamase. The kinetic properties of the enzyme ... [more ▼]

Cefoxitin and other beta-lactam antibiotics with a methoxy group on the alpha-face behave as very poor substrates of the Bacillus licheniformis beta-lactamase. The kinetic properties of the enzyme-cefoxitin system made it theoretically suitable for a detailed structural study of the acyl-enzyme. Unfortunately, soaking the crystals in cefoxitin solution did not allow detection of a crystalline acyl-enzyme complex. In contrast, direct observation by n.m.r. of the stable acyl-enzyme formed with cefoxitin and moxalactam indicated clear modifications of the enzyme structure, which were reflected in the aromatic and high-field methyl regions of the spectrum. The return to the initial free enzyme spectrum was concomitant with the hydrolysis of the acyl-enzyme, the process being slow enough to allow multidimensional n.m.r. experiments. [less ▲]

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