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See detailFollicular dendritic cells: isolation procedures, short and long term cultures.
Heinen, Ernst ULg; Tsunoda, R.; Marcoty, C. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailFractionnement du froment d'hiver : influences variétale et phytotechnique.
Sindic, Marianne ULg; Chevalier, Olivier; Duculot, Jacqueline et al

in Industries des Céréales (1993), (82),

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See detailSTUDY OF THE CRYSTALLIZATION PROCESS IN BI2-XPBXSR2CA2CU3O10-Y GLASS SYSTEMS - OPTICAL POLARIZED-LIGHT MICROSCOPY, ELECTRICAL AND MAGNETIC-PROPERTIES
Cloots, Rudi ULg; Romain, Anne-Claude ULg; Rulmont, André ULg et al

in Superconductor Science & Technology (1993), 6(12), 850-857

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C ... [more ▼]

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C for 96 or 144 h (with one intermediary grinding). High-resolution polarization micrographs and electrical (and magnetic susceptibility) measurements have been taken. Various growth mechanisms can thus be checked, and the physical properties are studied in relation to the microstructure. It is found that the 2223 phase does not crystallize directly from the amorphous one but results from a dissolution-reprecipitation process. The stability of the 2212 phase is emphasized. The 2201 phase precipitates at high temperature and rapidly reacts with the melt to form the 2223 phase. The kinetics of the lead-substituted sample seems to be controlled by the Ca2PbO4 phase. which acts as a flux. [less ▲]

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailLa didactique universitaire : des méthodes et techniques à la redéfinition des objectifs
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (1993), (232), 25-32

Courte réflexion sur la pédagogie universitaire portant à la fois sur les méthode set techniques et les objectifs de l'enseignement

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See detailBiological control of Botrytis cinerea and Penicillium sp. on post-harvest apples two antagonist yeasts.
Jijakli, Haissam ULg; Lepoivre, Philippe ULg; Tossut, P. et al

in Mededelingen - Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent (1993), 58(3b),

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See detailMicroencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase
Nihant, Nicole; Stassen, S; Grandfils, Christian ULg et al

in polymer International (1993), 32

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This ... [more ▼]

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium. [less ▲]

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See detailBovine leukemia virus, an animal model for the study of intrastrain variability.
Willems, Luc ULg; Thienpont, E.; Kerkhofs, P. et al

in Journal of Virology (1993), 67(2),

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See detailProduction of hemicellulase by Penicillium canescens 10-10C. Arch. Int. Phys. Bioch., 101, B1-B00.
Fonder, C.; Rikir, R.; Kvesitadze, G. et al

in Archives Internationales de Physiologie et de Biochimie (1993), 101(B1-B100),

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See detailNew Immigrants and Democratic Society. Minority Integrations in Western Societies
Martiniello, Marco ULg

in International Migration Review (1993), 27(101), 204-205

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See detailCompte rendu de Bibliothèque Nationale. Catalogue des Homéliaires
George, Philippe ULg

in Moyen Age (Le) (1993)

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See detailTransmission, Recombination and Conversion of Mitochondrial Markers in Relation to the Mobility of a Group I Intron in Chlamydomonas
Remacle, Claire ULg; Matagne, René-Fernand ULg

in Current Genetics (1993), 23(5-6, May-Jun), 518-25

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs ... [more ▼]

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs cob. 1 or alpha intron), three restriction sites (Nh, Nc and H markers) located 0.5-5 kb from the insertion site of the intron, and a MUD2 point mutation (27 bp from the insertion site) conferring resistance to myxothiazol. Recombination between mitochondrial markers is a general property of all crosses and fusions analyzed. In crosses between two intron-containing (alpha+) strains or two intron-less (alpha-) strains, the transmission is preferentially paternal (mt-), with a preponderance depending on the nature of the parental genomes. In crosses between alpha+ and alpha- strains, the conversion of intron-less molecules intron+ is frequent when the alpha+ parent is maternal (mt+) and nearly absolute when the alpha+ parent is paternal (mt-). In 94% of cases, the conversion is accompanied by the co-conversion of the MUD2 marker. In both crosses and artificial fusions, the conversion of alpha- into alpha+ also influences the transmission of the more distant Nh, Nc and H markers. It is hypothesized that the more frequent transmission of the genome containing the intron results from the elimination of alpha- molecules, as a result of a double-strand cut which is induced by an endonuclease encoded by the intron. [less ▲]

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See detailA concise guide to the temporal maze
Richelle, Marc ULg

in Psychologica Belgica (1993), 33(2), 135-145

The paper provides a concise historical survey of the expanding field of time psychology, pointing to the important contributions, in its early stages as well as today, of European psychologists. An ... [more ▼]

The paper provides a concise historical survey of the expanding field of time psychology, pointing to the important contributions, in its early stages as well as today, of European psychologists. An evaluation of past and current research is proposed, and prospects for further development suggested, especially with regard to neglected areas and to issues related to applied situations. [less ▲]

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See detailLa decharge egale un bioreacteur a gerer.
Dumont, M.; Taillieu, X.; Destain, Jacqueline ULg et al

in Tribune de l'Eau (La) (1993), 46(564), 3-10

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See detailReturn interval, firm size and systematic risk on the Dutch stock market
Corhay, Albert ULg; Tourani-Rad, Alireza

in Review of Financial Economics (1993), 2(2), 19-28

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See detailLes auteurs latins et les langues étrangères
Rochette, Bruno ULg

in Latomus : Revue d'Etudes Latines (1993), 52

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See detailL'éducation, un acte fondamental
de Landsheere, Gilbert ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1993), (67-69), 65-81

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See detailMesures quantitatives de l'erythropoiese. Le recepteur soluble de la transferrine.
Beguin, Yves ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1993), 148(1-2), 100-4105-7

Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor. The soluble form of the transferrin receptor has been ... [more ▼]

Iron transport in plasma is carried out by transferrin, which donates iron to cells through its interaction with a specific membrane receptor. The soluble form of the transferrin receptor has been identified in plasma. Dosage of the soluble receptor represents a simple, reliable, quantitative assay of erythropoiesis, which should replace the standard ferrokinetic measurement. Using this dosage, it is now possible to investigate the pathophysiology of anemia in many conditions, and to analyze the erythropoietic response to treatment with recombinant erythropoietin. [less ▲]

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See detailFurther studies on the genetic diversity of lima beans (Phaseolus lunatus L.) using allozymes
Maquet, Alain; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (1993), 36

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See detailContribution à l'étude des effets de l'exposition à des champs magnétiques 50 Hz sur certains paramètres neuropsychologiques et neuroendocriniens
Crasson, Marion ULg; Timsit-Berthier, Martine; Legros, Jean-Jacques ULg

in Psychologie Médicale (1993), 25(13), 1341-1346

Depuis une trentaine d'années, l'exposition des populations industrialisées aux champs électromagnétiques 50/60 Hz n'a cessé de susciter des polémiques concernant ses éventuels effets nocifs. Cette étude ... [more ▼]

Depuis une trentaine d'années, l'exposition des populations industrialisées aux champs électromagnétiques 50/60 Hz n'a cessé de susciter des polémiques concernant ses éventuels effets nocifs. Cette étude préliminaire a été réalisée avec un appareillage original, qui génère des champs magnétiques comparables à ceux rencontrés dans la vie quotidienne. Deux groupes de 10 volontaires en bonne santé ont participé à cette recherche, le premier réellement exposé à un champ d'induction magnétique de 142 microtesla, 50 Hz, pendant une demi-heure, le deuxième exposé de manière simulée. Nos résultats montrent que le champ magnétique n'engendre aucun effet perceptible mais qu'il provoque une légère modification de certains paramètres psychologiques (humeur, attention visuelle). [less ▲]

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 2 (NEM-2).
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 316-22

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See detailPilot study of flesinoxan in major depression. Effect on REM latency and body temperature
ANSSEAU, Marc ULg; PITCHOT, William ULg; Gonzalez Moreno, Antonio et al

in Human Psychopharmacology (1993)

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See detailModelling the Arterial Wall by Finite Elements
Mosora, F.; Harmant, A.; Hallet, Claude ULg et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1993), 101(3, May-Jun), 185-91

The mechanical behaviour of the arterial wall was determined theoretically utilizing some parameters of blood flow measured in vivo. Continuous experimental measurements of pressure and diameter were ... [more ▼]

The mechanical behaviour of the arterial wall was determined theoretically utilizing some parameters of blood flow measured in vivo. Continuous experimental measurements of pressure and diameter were recorded in anesthetized dogs on the thoracic ascending and midabdominal aorta. The pressure was measured by using a catheter, and the diameter firstly, at the same site, by a plethysmograph with mercury gauge and secondly, by a sonomicrometer with ferroelectric ceramic transducers. The unstressed radius and thickness were measured at the end of each experiment in situ. Considering that the viscous component is not important relatively to the nonlinear component of the elasticity and utilizing several equations for Young modulus calculation (thick and thin wall circular cylindrical tube formulas and Bergel's equation) the following values were obtained for this parameter: 0.6 MPa-2 MPa in midabdominal aorta and 2 MPa-6.5 MPa in thoracic ascending aorta. The behaviour of the aorta wall was modelled considering an elastic law and using the finite element program "Lagamine" working in large deformations. The discretized equilibrium equations are non-linear and a unique axi-symmetric, iso-parametric element of 1 cm in length with 8 knots was used for this bi-dimensional problem. The theoretical estimation of radius vessel, utilizing a constant 5 MPa Young modulus and also a variable one, are in good agreement with the experimental results, showing that this finite element model can be applied to study mechanical properties of the arteries in physiological and pathological conditions. [less ▲]

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See detailApplying the Lagamine model to compute land subsidence in Shanghai
Dassargues, Alain ULg; Schroeder, Christian ULg; Li, Xiang Lin

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailLes erreurs humaines en anesthésie
De Keyser, Véronique ULg; Nyssen, Anne-Sophie ULg

in Travail Humain (Le) (1993), 56(2-3), 243-266

Human errors in anesthesia - with due respect to the French-speaking tradition, human error is studied in field work, here in anesthesia. The authors specify the social context, compare the process of ... [more ▼]

Human errors in anesthesia - with due respect to the French-speaking tradition, human error is studied in field work, here in anesthesia. The authors specify the social context, compare the process of anesthesia to a continuous process, present a cognitive analyse of the task, emphasizing temporal characteristics and cognitive demands regarding the cognitive aspects of human behavior. Referring to the dictinction made by Hollnagel (1991) between reliability, robustness and adaptiveness of the system (man and machine), they present and analyse some human errors which reveal the importance of variation elements and the dynamic dimension of the environment. Influenced by Time Psychology, they postulate the existence of different systems of temporal reference and of external synchronizers connected to these systems, which would allow an individual to adaptively respond to the demands for synchronization in the face of events and actions whose evolutions cannot be calibrated in clock time. Inadequate systems of temporal reference and the absence of synchronizers can make this adaptation to the evolution and the dynamicity of the environment fail. The prevention integrates different measures (technological, ergonomic, social, organizational, of expertise development, etc.) and relies on collection and in-depth analysis of human error. This paper is dedicated to J. Leplat. [less ▲]

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 1 (NEM-1).
Ghuysen, Alexandre ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 309-63

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See detailImportance of Weight Loss and Sodium Restriction in the Treatment of Mild and Moderate Essential Hypertension
Krzesinski, Jean-Marie ULg; Janssens, Marion; Vanderspeeten, Francine et al

in Acta Clinica Belgica (1993), 48(4), 234-245

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however ... [more ▼]

The effectiveness of non pharmacological treatment of chronic arterial hypertension has been evaluated in 116 treated or not primary hypertensive out-patients. Those receiving diuretics were however excluded. This population was requested to follow for 3 months a modification of their usual diet characterized by salt restriction combined with energy intake restriction when the patients were above their ideal body weight. Only 62 patients (53%) completed the study. However, this approach was effective by decreasing blood pressure and total cholesterol. The weight loss appears the most effective way to decrease blood pressure in untreated patients, but needs 3 months to be significant. In drug-treated patients, the sodium restriction significantly influences the blood pressure level, already after 1 month. However, salt sensitivity has been noted, especially in the most severe forms of the hypertensive disease. The combination of both modifications (weight loss and sodium restriction) does not appear to be more effective than each separate dietary measure. [less ▲]

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See detailMaghrébins en Europe
Martiniello, Marco ULg; Geisser, V.; Lorcerie, F. et al

in Annuaire de l'Afrique du Nord (1993), XXXII

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See detailCharacterization of polygalacturonase from Kluyveromyces marxianus.
Campos, D.; Rikir, R.; Taillieu, X. et al

in Archives Internationales de Physiologie et de Biochimie (1993), 101(B1-B25),

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See detailExiste-t'il une Europe de l'épargne?
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Reflets et Perspectives de la Vie Economique (1993), (32), 37-59

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See detail"Influence of bioreactor aeration conditions on sporulation rate of Bacillus subtilis (b 213 stream)"
Meurisse, E.; Hbid, Ch.; Jacques, Ph. et al

in Mededelingen - Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent (1993), 58(4b), 1985-1987

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See detailScaled effective chiral lagrangians for the propagation of scalar and vector mesons in dense matter
Jaminon, Martine ULg; Ripka, Georges

in Nuclear Physics A (1993), 564

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See detailSaving behavior in 17 OECD countries
Kessler, Denis; Pestieau, Pierre ULg; Perelman, Sergio ULg

in Review of Income and Wealth (1993), (39), 37-50

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of ... [more ▼]

This article compares savings behavior in a sample of 17 OECD countries over 24 years. On the basis of an analysis of variance and of a life-cycle-hypothesis-based equation, we test the homogeneity of households' savings behavior. It appears that one cannot really speak of a homogeneous saving behavior across countries. This is a relevant finding in times of increasing economic and financial integration. [less ▲]

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See detailThe oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.
Bours, Vincent ULg; Franzoso, G.; Azarenko, V. et al

in Cell (1993), 72(5), 729-39

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly ... [more ▼]

Bcl-3 is an I kappa B-related protein with ankyrin repeat motifs. Its gene is located at a site of recurrent translocations in a subset of B cell chronic lymphocytic leukemias. Bcl-3 associates tightly with p50B (NFKB2, p52) homodimers in cells, and together these proteins form a ternary complex with DNA at kappa B sites. Such an association functionally leads to a novel and potent form of transactivation through the kappa B motif: the tethering of Bcl-3 to DNA via the p50B homodimers allows Bcl-3 to transactivate directly, while p50B homodimers alone cannot. Transactivation mediated by Bcl-3 requires two cooperating domains located amino- and carboxy-terminal to the ankyrin domain. Bcl-3 is localized to the nucleus, and a Bcl-3-p50B complex is detected in certain lymphoid cells. Our data reveal a novel role for Bcl-3, distinct from that of the inhibitor I kappa B. The results have implications for tumorigenesis. [less ▲]

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See detailMicrosatellite mapping of the gene causing weaver disease in cattle will allow the study of an associated QTL
Georges, Michel ULg; Lathrop, M.; Dietz, A. B. et al

in Proceedings of the National Academy of Sciences of the United States of America (1993), 90

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from ... [more ▼]

A genetic disease in cattle, progressive degenerative myeloencephalopathy (weaver disease), is associated with increased milk production. This association could result from population stratification, from a pleiotropic effect of a single gene, or from linkage disequilibrium between the gene causing weaver disease and a quantitative trait locus (QTL) for milk production. To test these hypotheses, we performed an extensive linkage study in a bovine pedigree segregating for the weaver condition and identified a microsatellite locus (TGLA116) closely linked to the weaver gene (zmax, 8.15; theta, 0.03). TGLA116 and, by extension, the weaver locus were assigned to bovine synteny group 13. This microsatellite can be used to identify weaver carriers, to select against this genetic defect, and to study the effect of the corresponding chromosomal region on milk production in Brown Swiss and other breeds of cattle. [less ▲]

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See detailChiral theory of mesons in dense baryonic matter (II) : Meson propagation
Jaminon, Martine ULg; Mendez Galain; Stassart, Pierre ULg

in Nuclear Physics A (1993), 556

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See detailBiological control of postharvest Botrytis cinerea and Penicillium on apples
Jijakli, Haissam ULg; Lepoivre, Philippe ULg

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (1993), (16), 106-110

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See detailAnalytical calculation of the electrostatic interaction energy within the CNDO framework
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in International Journal of Quantum Chemistry (1993), 46(6), 711-734

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab ... [more ▼]

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab initio results for small systems such as water-formamide, methanol-water-imidazole, or guanine-cytosine and with AM1 results for two large systems: a molecular tweezer + the 9-methyladenine complex and a model active site of the alpha-chymotrypsin and its ligand complex. This approach is efficient in providing reliable conformers for large molecular systems in a very fast way. [less ▲]

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See detailRecension bibliographique de "Pitcher T.J. & Hart P.J.B. : Fisheries ecology".
Poncin, Pascal ULg

in Cahiers d'Ethologie (1993), 13(3), 396

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Stavební Obzor (1993), 10

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See detailIntercultural Education in French-speaking Belgium : an overview of ideology, legislation and practice
Martiniello, Marco ULg; Manço, Altay

in European Journal of Intercultural Education (1993), 4(2), 19-28

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See detailCharacterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells.
Peers, Bernard ULg; Johnson, T.; Ferreri, K. et al

in Molecular Endocrinology (1993), 7(10), 1275-83

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number ... [more ▼]

The endocrine pancreas consists of several differentiated cell types that are distinguished by their selective expression of peptide hormones such as insulin, glucagon, and somatostatin. Although a number of homeobox-type factors have been proposed as key regulators of individual peptide genes in the pancreas, their cellular distribution and relative abundance remain uncharacterized. Also, their overlapping DNA binding specificities have further obscured the regulatory functions these factors perform during development. In this report we characterize a novel homeobox-type somatostatin transactivating factor termed STF-1, which is uniformly expressed in cells of the endocrine pancreas and small intestine. The 283-amino acid STF-1 protein binds to tissue-specific elements within the somatostatin promoter and stimulates somatostatin gene expression both in vivo and in vitro. Remarkably, STF-1 comprises the predominant tissue-specific element-binding activity in nuclear extracts from somatostatin-producing pancreatic islet cells, suggesting that this protein may have a primary role in regulating peptide hormone expression and specifying endocrine cell lineage in the developing gut. [less ▲]

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See detailDinant/Anseremme: Trou Magrite
Noiret, Pierre ULg

in Chronique de l'Archéologie wallonne (1993), 1

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See detailIn vivo infection of sheep by bovine leukemia virus mutants.
Willems, Luc ULg; Kettmann, Richard ULg; Dequiedt, Franck ULg et al

in Journal of virology (1993), 67(7),

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See detailUne nouvelle approche des echanges gazeux entre couverts vegetaux et atmosphere. La correlation de turbulences.
Aubinet, Marc ULg

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(4),

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See detailAnalgesic Efficiency of Propacetamol Hydrochlorid after Lumbar Disc Surgery
Hans, Pol ULg; Brichant, Jean-François ULg; Bonhomme, Vincent ULg et al

in Acta Anaesthesiologica Belgica (1993), 44(4), 129-33

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients ... [more ▼]

The influence of intravenous propacetamol hydrochlorid administration on postoperative analgesia and intramuscular opioid consumption was assessed in a randomized placebo-controlled study. Fourty patients scheduled for lumbar disc surgery were randomly allocated to two groups. They were given either propacetamol 2 g or saline every 6 hours, starting at the end of procedure for a 24 hours period. The pain intensity (VAS) was not significantly different between the two groups except 3 and 4 hours after surgery, where it was higher in the paracetamol group. The cumulative narcotic consumption (piritramide on request) was higher in the placebo group from 6 hours till 9 hours after surgery but not significantly different after 24 hours. Piritramide administration decreased VAS score significantly in both groups while propacetamol reduced it in a significant way only when given from 12 hours after surgery. [less ▲]

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See detailConnection and frame design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in New Steel Construction (1993), 1(N°6), 30-33

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See detailThe 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
Clapp, Carmen; Martial, Joseph ULg; Guzman, Raphaël C et al

in Endocrinology (1993), 133(3), 1292-9

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable ... [more ▼]

The formation of a new blood supply, angiogenesis, is an essential component of carcinogenesis and unrestricted tumor growth. A substance capable of inhibiting angiogenesis would be of considerable therapeutic potential in the treatment of cancer. We previously reported that the 16-kilodalton N-terminal fragment of rat PRL (16K rPRL) was a potent inhibitor of capillary endothelial cell proliferation via a novel receptor. We now report that the nanomolar concentrations of recombinant human 16K PRL inhibit basal and basic fibroblast growth factor- or vascular endothelial growth factor-stimulated growth of bovine brain capillary endothelial cells. 16K human (h) PRL also inhibits stimulation of human umbilical vein endothelial cell proliferation by basic fibroblast growth factor. The organization of endothelial cells into capillary-like structures in type I collagen gels is also prevented by 16K hPRL. Furthermore, in an in vivo assay, the chick embryo chorioallantoic membrane assay, 16K hPRL as well as 16K rPRL were potent inhibitors of capillary formation. 16K hPRL, like 16K rPRL, maintains its biological activity as a partial PRL agonist at PRL receptors on mammary gland epithelial cells. These data demonstrate for the first time that the biological activity of 16K rPRL is not unique and that similar fragments of hPRL are active. The antiangiogenic activity of these molecules is conserved across avian and mammalian species. That 16K hPRL is a potent antiangiogenic factor in in vitro and an in vivo assay raises the exciting potential of this peptide being capable of inhibiting tumor growth. [less ▲]

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See detailEffect of the vector-axial-vector coupling on the vector-meson modes
Jaminon, Martine ULg; Mendez Galain, Ramon

in Nuclear Physics A (1993), 564

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See detailOptimal Foraging By Hoverflies (Diptera, Syrphidae) And Ladybirds (Coleoptera, Coccinellidae) - Mechanisms
Hemptinne, Jl.; Dixon, Afg.; Doucet, Jean-Louis ULg et al

in European Journal of Entomology (1993), 90(4), 451-455

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines ... [more ▼]

Coccinellids and syrphids that feed on aphids and coccids face the same problem: an unstable food supply. Their eggs and larvae face cannibalism and/or starvation if the aphid colony they attack declines in abundance before they mature. Optimal foraging theory predicts that such predators should lay a few eggs early in the development of an aphid colony. Studies on two species of coccinellid and one species of syrphid revealed that they do respond to the quality as well as the abundance of their prey. By refraining from laying eggs in aphid colonies already exploited by predators and those that are shortly to decline in abundance when the aphids disperse, these predators are able to forage in a way that is consistent with the predictions of optimal foraging theory. [less ▲]

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See detailRetrieval failures in face naming
Brédart, Serge ULg

in Memory (1993), 1(4), 351-366

Several authors have reported that the incidence of retrieval failures is higher for people's names than for object names. The first aim of the paper was to evaluate the role of one factor that might ... [more ▼]

Several authors have reported that the incidence of retrieval failures is higher for people's names than for object names. The first aim of the paper was to evaluate the role of one factor that might contribute to making face naming difficult. Face naming usually requires the retrieval of one specific label: the name of the seen individual. Object naming is less restricting. First, object names may have synonyms. Second, labels available from different levels of categorisation of an object may be appropriate to name that object (e.g. trousers, jeans, Levis). Such a degree of freedom does not exist in naming faces. The hypothesis that face naming is made difficult by the simple fact that people have only one name was tested by studying faces having the exceptional property of bearing two names: faces of actors playing nameable characters (e.g. Harrison Ford playing Indiana Jones). Consistent with the hypothesis, data from two experiments showed that when bypassing a block is possible by producing another name that is known for a face, the incidence of blocks falls dramatically. The other aim of the paper was to test the reversed frequency effect in person naming reported previously in several diary studies, in an experimental setting. A direct frequency effect rather than a reversed frequency effect was obtained in the present study. [less ▲]

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See detailConnection and frames design for economy
Anderson, D.; Colson, A.; Jaspart, Jean-Pierre ULg

in Rakennustekniikka = Finnish Civil Engineering Journal (1993), 3/93

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See detailinfections par streptocoque B en période néonatale
Battisti, Oreste ULg; Vanclaire, J.; François, A. et al

in Archives Françaises de Pédiatrie (1993), 50

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See detailMR1240747,Hromadka, II, Theodore V.,The best approximation method in computational mechanics
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (1993)

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See detailTextual Space in Un chien Andalou
Drummond, Philippe; Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1993), 33-35

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See detailReaction Dynamics of the Dichlorocarbene Anion Using tandem Mass Spectrometry.
Leyh, Bernard ULg; Mélon, Pierre

in Organic Mass Spectrometry (1993), 28

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of ... [more ▼]

The dissociation dynamics of CCl2- anions were studied under various internal energy conditions. This study involved the measurement of daughter-ion spectra and branching ratios and of the amount of kinetic energy released (KER) on the fragments. The competition between C and Cl loss for CCl2- ions created by many of the following sequence of processes: CCl4->CCl2+->(G=Xe, Kr C6H6)->CCl2--> fragments (1); CCl4->(CCl2--+[Cl,Cl]+;CCl2-; CCl2- (Ne)-> Fragments (2); CCl4->(CCl2)2+ (C6H6)->CCl2--> fragments (3) was particularly investigated. For process (1), the amount of fragmentating CCl2- ions is 8-10 times larger with Kr than with Xe or C6H6. The KER for Cl loss is smaller than 0.20 eV with the three target gases used. For the loss of C, the KER is much larger (0.7 eV). This KER is, however, equal to 0.21 eV for the collisionally activated C loss in process (2). For this latter process, the C loss vs Cl loss branching ratio decreases with increasing internal energy. The KERs measured for process (3) are vary similar to those obtained for process (1). It is suggested that repulsive or slightly bound excited states which correlate directly to the Cl2-(X2Sigma+)+C asymptote and which are vibronically coupled to the ground state play an important role in these dissociation processes. [less ▲]

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See detailA finite element code for subsidence problems: LAGAMINE
Charlier, Robert ULg; Radu, Jean-Pol ULg; Li, Q. F.

in Bulletin of Engineering Geology & the Environment (1993), 47(1 / avril), 5-11

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See detailLa voie navigable Anvers-Dusseldorf pour une liaison Meuse-Rhine
Rigo, Philippe ULg

in Bulletin de l’Association Internationale Permanente des Congrès de Navigation [Bulletin de l'AIPCN] (1993)

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See detailL'agriculteur et les aides directes aux revenus
Lebailly, Philippe ULg

in Nouvelles des Sciences et des Technologies (1993), 11(2), 171-176

Le but de cet article est de présenter les différents volets de la politique agricole qui permettent un soutien aux agriculteurs par le biais d'aides directes aux revenus. Après avoir présenté le ... [more ▼]

Le but de cet article est de présenter les différents volets de la politique agricole qui permettent un soutien aux agriculteurs par le biais d'aides directes aux revenus. Après avoir présenté le dispositif mis en place en Belgique pour les régions agricoles défavorisées, l'auteur s'attarde sur les aspects de la réforme de la PAC qui introduisent les paiements directs. Les changements les plus importants concernant les cultures arables et le fonctionnement du système sont présentés de manière détaillée. Enfin, l'auteur présente les mesures d'accompagnement de la réforme de la politique des marchés et des prix. [less ▲]

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See detailRed Blood Cell Na-Li Countertransport, Hypertensive Heredity, and Cardiovascular Risk in Young Adults
Krzesinski, Jean-Marie ULg; Saint-Remy, Annie ULg; Du, F. et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (1993), 6(4), 314-316

The erythrocyte Na-Li countertransport (CT) has been considered as a marker of genetic propension to essential hypertension, but also to be linked to atherosclerosis risk factors. We have evaluated these ... [more ▼]

The erythrocyte Na-Li countertransport (CT) has been considered as a marker of genetic propension to essential hypertension, but also to be linked to atherosclerosis risk factors. We have evaluated these relationships by measuring the Na-Li CT, blood pressure levels, the family predisposition to hypertension, body mass index, subscapular skin-fold thickness, waist/hip ratio, and plasma lipids in 43 young adults (22 to 23 years; 13 with a positive family history of hypertension), followed since adolescence (+/- 10 years) to analyze the natural history of blood pressure in this period of life. The Na-Li CT was negatively correlated with the HDL cholesterol (r = -0.37) and the HDL cholesterol/total cholesterol ratio (r = -0.44). This transport system was positively correlated to family history of hypertension (r = 0.38), waist/hip ratio, and the diastolic blood pressure. When the family history of hypertension was present, Na-Li CT and diastolic blood pressure were higher (P < .05), but the HDL cholesterol was lower (P < .01). After separating people according to the blood pressure level during adolescence in two groups, one lower than the 75th percentile (P75), and one higher, we notice that the latter remains characterized by a higher systolic blood pressure. But neither the Na-Li CT nor family history of hypertension and plasma lipids could explain the difference in the blood pressure behavior during this period. Thus, an increase of RBC Na-Li CT activity in young adults would suggest a higher cardiovascular risk rather than to be a simple marker of a hypertensive risk. [less ▲]

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See detailLa racine grb et l'Amon-grb
Malaise, Michel ULg; Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1993), 68

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See detailPressure effects, kinetics, and rheology of anorthositic and related magmas
Longhi, John; Fram, Miranda; Vander Auwera, Jacqueline ULg et al

in American Mineralogist (1993), 78

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See detailMutational analysis of the p50 subunit of NF-kappa B and inhibition of NF-kappa B activity by trans-dominant p50 mutants.
Bressler, P.; Brown, K.; Timmer, W. et al

in Journal of Virology (1993), 67(1), 288-93

The NF-kappa B family of DNA-binding proteins regulates the expression of many cellular and viral genes. Each of these proteins has an N-terminal region that is homologous to the c-Rel proto-oncogene ... [more ▼]

The NF-kappa B family of DNA-binding proteins regulates the expression of many cellular and viral genes. Each of these proteins has an N-terminal region that is homologous to the c-Rel proto-oncogene product, and this Rel homology region defines both DNA binding and protein dimerization properties of the individual proteins. Most of the NF-kappa B family members have been shown to associate with themselves or with each other to form homodimers or heterodimers, and previous studies have shown that dimerization of NF-kappa B factors is necessary to provide a functional DNA binding domain. We have used site-directed mutagenesis to identify regions in the Rel homology domain of the p50/NF-kappa B protein that are important for DNA binding and protein dimerization. Our studies have identified mutations of p50 that interfere with DNA binding only and those that interfere with protein dimerization. Mutations of p50 which disrupt only DNA binding were still able to associate with other members of the NF-kappa B protein family. We demonstrate that such heterodimeric complexes inhibit transcriptional activation mediated in trans through a cis-acting kappa B motif; therefore, we have identified trans-dominant negative mutants of p50. [less ▲]

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See detailLaparoscopy, urology, and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailAbility Of Amitraz To Maintain The Predator Exochomus-Quadripustulatus L (Col, Coccinellidae) In An Integrated Management Of Epulvinaria-Hydrangeae (Steinw) (Hom, Coccidae)
Tondeur, R.; Merlin, J.; Schiffers, Bruno ULg et al

in Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie (1993), 115(1),

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See detailEmptinne : villa gallo-romaine de Champion (signalement archéologique)
Longrée, Dominique ULg; Breyer, Catherine; De Poorter, Alexandra

in Chronique de l'Archéologie Wallonne (1993), 1989(Juin 92), 105

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See detailThe oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
Franzoso, G.; Bours, Vincent ULg; Azarenko, V. et al

in EMBO Journal (1993), 12(10), 3893-901

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF ... [more ▼]

Previously we have proposed a role for Bcl-3 in facilitating transactivation through kappa B sites by counteracting the inhibitory effects of bound, non-transactivating homodimers of the p50 subunit of NF-kappa B. Such homodimers are abundant for example in nuclei of unstimulated primary T cells. Here we extend the model and provide new evidence which fulfills a number of predictions. (i) Bcl-3 preferentially targets p50 homodimers over NF-kappa B heterodimers since the homodimers are completely dissociated from kappa B sites at concentrations of Bcl-3 which do not affect NF-kappa B. (ii) Select kappa B sites associate very strongly and stably with p50 homodimers, completely preventing binding by NF-kappa B. Such kappa B sites are likely candidates for regulation by p50 homodimers and Bcl-3. (iii) Bcl-3 and p50 can be co-localized in the nucleus, a requirement for active removal of homodimers from their binding sites in vivo. (iv) The ankyrin repeat domain of Bcl-3 is sufficient for the reversal of p50 homodimer-mediated inhibition, correlating with the ability of this domain alone to inhibit p50 binding to kappa B sites in vitro. Our data support the model that induction of nuclear Bcl-3 may be required during cellular stimulation to actively remove stably bound p50 homodimers from certain kappa B sites in order to allow transactivating NF-kappa B complexes to engage. This exact mechanism is demonstrated with in vitro experiments. [less ▲]

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See detailTraining-Induced Modifications in Cardiorespiratory and Ventilatory Measurements in Thoroughbred Horses
Art, Tatiana ULg; Lekeux, Pierre ULg

in Equine Veterinary Journal (1993), 25(6), 532-536

The effects of training and detraining on ventilation during a standardised exercise test were investigated. Ten healthy Thoroughbred horses underwent 5 standardised treadmill exercise tests (SET): SET1 ... [more ▼]

The effects of training and detraining on ventilation during a standardised exercise test were investigated. Ten healthy Thoroughbred horses underwent 5 standardised treadmill exercise tests (SET): SET1, at the start of the experimental period; SET2, after 3 weeks acclimatisation; SET3, after 3 week of aerobic training; SET4 after 3 weeks of anaerobic (i.e. interval) training; and SET5, after 3 weeks of detraining. The SETs were carried out in an air-conditioned laboratory on a treadmill inclined at 6 degrees. Respiratory airflow, tidal volume (VT), respiratory frequency (RF) and expired minute volume (VE) were obtained using a face mask and 2 ultrasonic pneumotachographs. Peak oxygen uptake (VO2 peak) and carbon dioxide production (VCO2 peak) values were calculated on a breath-by-breath basis, using a mass spectrometer. Heart rate (HR) was continuously measured with a polar horse tester. Oxygen pulse (VO2/HR) and ventilatory equivalent for O2 were calculated from the collected data. Venous blood was sampled before and after the SET for lactate, pH and haemoglobin determinations. The results indicated that trained horses showed significant modifications of all values, except VT, RF and VE. This study suggests that, in horses, the increase in VO2 induced by training seems to be mainly due to cardiovascular and haematological changes rather than to ventilatory changes. Consequently, while all the other systems implicated in exercise physiology can be efficiently improved and trained, the ventilatory capacity has only limited ability to adapt to training [less ▲]

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See detailDifferent Mechanisms of Extracellular Matrix Remodeling by Fibroblasts in Response to Human Mammary Neoplastic Cells
Noël, Agnès ULg; Munaut, Carine ULg; Nusgens, Betty ULg et al

in Invasion & Metastasis (1993), 13(2), 72-81

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties ... [more ▼]

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties. They may also directly interact with collagen fibrils leading to retraction of the matrix. We have studied in vitro the influence of various human mammary tumor cells on the proliferation rate of normal human fibroblasts and on their level of collagen synthesis, as well as their release of collagenase activity. Interactions between neoplastic cells and collagen matrix were investigated by incorporation of tumor cells in collagen gels (lattices) and measurement of their retraction. All cells tested (HBL100, SW613, SA52, MDA-MB-231, MCF7, MCF7/6, MCF7 ras, BT20 and T47D) were able to modulate the composition of the extracellular matrix by one or several of the mechanisms investigated. Our results also demonstrate an opposite regulation of collagen and collagenase production. The effects on the collagen metabolism and on fibroblast proliferation are probably mediated by soluble cytokines since they are reproduced by incubating the fibroblasts in the presence of medium conditioned by tumor cells. The desmoplastic reaction may thus result from different mechanisms dependent upon tumor cell types. [less ▲]

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See detailUn historique de la carte géologique de la Belgique
Boulvain, Frédéric ULg

in Professional paper Belgian geological survey (1993), 262

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See detailRetinoic acid induction of major histocompatibility complex class I genes in NTera-2 embryonal carcinoma cells involves induction of NF-kappa B (p50-p65) and retinoic acid receptor beta-retinoid X receptor beta heterodimers.
Segars, J. H.; Nagata, T.; Bours, Vincent ULg et al

in Molecular & Cellular Biology (1993), 13(10), 6157-69

Retinoic acid (RA) treatment of human embryonal carcinoma (EC) NTera-2 (NT2) cells induces expression of major histocompatibility complex (MHC) class I and beta-2 microglobulin surface molecules. We found ... [more ▼]

Retinoic acid (RA) treatment of human embryonal carcinoma (EC) NTera-2 (NT2) cells induces expression of major histocompatibility complex (MHC) class I and beta-2 microglobulin surface molecules. We found that this induction was accompanied by increased levels of MHC class I mRNA, which was attributable to the activation of the two conserved upstream enhancers, region I (NF-kappa B like) and region II. This activation coincided with the induction of nuclear factor binding activities specific for the two enhancers. Region I binding activity was not present in undifferentiated NT2 cells, but binding of an NF-kappa B heterodimer, p50-p65, was induced following RA treatment. The p50-p65 heterodimer was produced as a result of de novo induction of p50 and p65 mRNAs. Region II binding activity was present in undifferentiated cells at low levels but was greatly augmented by RA treatment because of activation of a nuclear hormone receptor heterodimer composed of the retinoid X receptor (RXR beta) and the RA receptor (RAR beta). The RXR beta-RAR beta heterodimer also bound RA responsive elements present in other genes which are likely to be involved in RA triggering of EC cell differentiation. Furthermore, transfection of p50 and p65 into undifferentiated NT2 cells synergistically activated region I-dependent MHC class I reporter activity. A similar increase in MHC class I reporter activity was demonstrated by cotransfection of RXR beta and RAR beta. These data show that following RA treatment, heterodimers of two transcription factor families are induced to bind to the MHC enhancers, which at least partly accounts for RA induction of MHC class I expression in NT2 EC cells. [less ▲]

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See detailApports récents de la génétique dans les maladies inflammatoires intestinales
Louis, Edouard ULg; Belaiche, Jacques ULg; Franchimont, D. et al

in Acta Clinica Belgica (1993), 48(6), 383-91

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the ... [more ▼]

It is clear since many years that the liability to develop inflammatory bowel disease is influenced by genetic factors. Recent progresses in the field of genetic markers and genetic models bring the concept of genetic heterogeneity. This new concept leads us to try to classify different forms of inflammatory bowel disease and could have in the future an impact on the prevention, the follow up and the treatment of these diseases. [less ▲]

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See detailLa descendance de celt. *AKARNOS en wallon
Boutier, Marie-Guy ULg

in Revue de Linguistique Romane (1993)

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See detailUltrastructural distribution of DNA and RNA within the nucleolus of human Sertoli cells as seen by molecular immunocytochemistry.
Thiry, Marc ULg

in Journal of Cell Science (1993), 105 ( Pt 1)

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli ... [more ▼]

The precise distribution of DNA and RNA within the human Sertoli cell nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. In Sertoli cells, the nucleolar components show a typical spatial distribution. The fibrillar centres are not surrounded by a layer of dense fibrillar component, but come in contact only with strands of dense fibrillar component. These fibrillar parts of strands are the extensions of granular strands connected to a large granular mass. These strands delimit numerous nucleolar interstices in which chromatin fibres are clearly obvious. Using the in situ terminal deoxynucleotidyl transferase/immunogold procedure for detecting DNA, we find evident label exclusively over the chromatin fibres enclosed in the nucleolar interstices and over the fibrillar centres, and no significant label over the dense fibrillar component and granular component of the nucleolus. Furthermore, using the polyadenylate nucleotidyl transferase/immunogold procedure for detecting RNA, we show that label is deposited not only over the granular component and dense fibrillar component, as expected, but also quite obviously over the fibrillar centres. No label is seen over the interstices containing chromatin. [less ▲]

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See detailControl of the illegal administration of natural steroid hormones in urine and tissues of veal calves and in plasma of bulls
Scippo, Marie-Louise ULg; Gaspar, Pol; Degand, Guy ULg et al

in Analytica Chimica Acta (1993), 275(1-2), 57-74

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See detailNUCLEOPHILIC ENANTIOSELECTIVE SYNTHESIS OF 6-[F-18]FLUORO-L-DOPA VIA 2 CHIRAL AUXILIARIES
Lemaire, Christian ULg; Plenevaux, Alain ULg; Cantineau, Robert et al

in Applied Radiation & Isotopes (1993), 44(4), 737-744

Asymmetric nucleophilic synthesis of 6-[F-18]fluoro-L-dopa was investigated in order to reach an enantiomeric excess of close to 100% of the L form of this amino acid. The radiochemical synthesis required ... [more ▼]

Asymmetric nucleophilic synthesis of 6-[F-18]fluoro-L-dopa was investigated in order to reach an enantiomeric excess of close to 100% of the L form of this amino acid. The radiochemical synthesis required [F-18]fluoride as fluorinating agent and regioselective nucleophilic substitution of commercially available 6-nitroveratraldehyde. The [F-18]fluorobenzaldehyde thus obtained was easily converted to the corresponding 2-[F-18]fluoro-4,5-dimethoxybenzyl bromide. This alkylating agent was added to the lithium enolates of 1-(S)-(-)camphor imine of t-butyl glycinate (1) and (S)-(-)- 1 -Boc-2-t-butyl-3-methyl-4-imidazolidinone [(S)- Boc-BMI] (2) in order to compare the enantiomeric excess of the L form obtained in each case with these two chiral inductors. The L-isomer of fluorodopa was isolated after H1 hydrolysis and HPLC purification in 5-10% radiochemical yield (decay corrected). The overall synthesis time was of 110 min. Through this synthetic pathway, the L-isomer of fluorodopa was obtained in 83% e.e with 1 and 96% e.e with 2 respectively, as determined by chiral HPLC. A practical three step preparative scale synthesis of 6-[F-19]fluoro-D,L-dopa is also presented. [less ▲]

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See detailTemperature, air humidity and air pollution levels in breeding pig houses
Nicks, Baudouin ULg; Canart, B.; Vandenheede, Marc ULg

in Pigs News and Information (1993), 14(2), 77-78

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to ... [more ▼]

A study was undertaken to provide practical information concerning the frequency of temp. and RH measurements required to obtain a good estimate of their averages and of their daily variations, and to determine the relationships between ammonia, carbon dioxide and bacterial concn in a pig house. Measurements were made in 9 artificially ventilated farrowing or weaner houses with slatted floors. Temp. and RH were measured every 20 min for 7 d. Sensors were placed inside buildings in the middle of the houses, 0.8 m above floor level, and outside the buildings. Data were recorded using a datalogger. Ammonia and carbon dioxide concn were measured using 8 h Gastec diffusion tubes. Three readings were taken in the same location at 2-day intervals. The airborne bacterial concn was measured with a 6-stage Andersen sampler. Bacteria colony forming particles (BCFP) were collected by impacting onto agar-filled petri dishes which are placed in an incubator for 24 h prior to counting the colonies formed. Results are discussed, indicating no significant correlation between the 3 measures of pollution (NH3 and CO2 concn, BCFP levels) despite careful microclimate control. [less ▲]

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See detailStructure, function and assembly of the nucleolus.
Scheer, U.; Thiry, Marc ULg; Goessens, Guy ULg

in Trends in Cell Biology (1993), 3(7), 236-41

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins ... [more ▼]

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis. [less ▲]

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See detailGLUCOCORTICOIDS AS DOPING AGENTS IN HOMING PIGEONS
Duchatel, Jean-Pierre ULg; Beduin, Jean-Marie ULg; Jauniaux, Thierry ULg et al

in Annales de Médecine Vétérinaire (1993), 137(8), 557-564

Different commercially available glucocorticoids that could be used to dope racing pigeons have been evaluated using zootechnical and biological parameters. The influence of these corticosteroids on blood ... [more ▼]

Different commercially available glucocorticoids that could be used to dope racing pigeons have been evaluated using zootechnical and biological parameters. The influence of these corticosteroids on blood values have been investigated. Toxicity of triamcinolone diacetate varied proportionally to injected doses and the main effects observed were lymphoid tissue alterations, muscular atrophy with breast muscles fibers vacuolation, fatty degeneration of liver and kidneys, hypoplasia or atrophy of gonads, and, in the blood, a significant increase of calcium and triglycerides levels. Prednisolone acetate in ocular drops was less toxic than dexemathasone and fluocinolone acetonide. The type of corticoids also had an influence on hemoglobin, glucose, and creatinine levels. The inhibition of the molt was also observed and varied with the sort of product used. [less ▲]

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See detailDes inscriptions de sceaux-cylindres diverses provenant d'Acemhöyük
Tunca, Önhan ULg

in Aspects of Art and Iconography: Anatolia and its Neighbors. Studies in Honor of Nimet Özgüç (1993)

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See detailComment assurer efficacement le dépistage de l'ostéoporose ?
Reginster, Jean-Yves ULg

in Lettre du Rhumatologue (La) (1993), 196

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See detailAspects cliniques de la néoplasie endocrinienne multiple de type 1 (NEM-1)
Ghuysen, Alexandre ULg; Beckers, Albert ULg; Stevenaert, Achille ULg

in Médecine & Chirurgie Digestives (1993), 22(8), 468-470

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See detailImmunodetection of RNA on ultra-thin sections incubated with polyadenylate nucleotidyl transferase.
Thiry, Marc ULg

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1993), 41(5), 657-65

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and ... [more ▼]

A new method is described for locating RNA on ultra-thin sections. Sections of aldehyde-fixed, plastic-embedded cells were incubated in a medium containing polyadenylate nucleotidyl transferase (PnT) and biotinylated ATP. The labeled nucleotides bound to RNA at the surface of the ultra-thin sections were than visualized by an indirect immunogold labeling technique. The resulting labeling pattern was dependent on the presence of divalent cations in the PnT medium. The method revealed with great precision the specific RNA-containing structures within Ehrlich tumor cells. The method is applicable to Epon sections. However, the labeling intensity varies according to the fixation used. Best results were obtained on acetylated cell sections. The method can be combined with EDTA regressive staining. The in situ PnT method provides a very useful tool for pinpointing the precise location of RNA within biological material at the ultrastructural level. [less ▲]

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See detailCompte-rendu de J. Cerny : Papyrus hiératiques de Deir-el-Médineh
Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1993), 78

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See detailStructure of the 16 S ribosomal RNA of the thermophilic cyanobacterium Chlorogloeopsis HTF (‘Mastigocladus laminosus HTF’) strain PCC75 18, and phylogenetic analysis
Wilmotte, Annick ULg; Van Der Auwera, Gert; De Wachter, Rupert

in FEBS Letters (1993), 317

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to ... [more ▼]

The thermophilic cyanobacterial strain, PCC7518, originally identified as ‘Mu~tigocludus hminosus HTF’ does not show branchings or heterocysts. The absence of branchings supports the later assignment to the genus Chlorogloeopsu. The absence of heterocysts may be the result of a mutation because heterocysts were observed in the original isolate. Alternatively, contamination may have happened. To solve this problem, the 16 S rRNA sequence was determined and used to infer a secondary structure model and build distance trees. The trees showed that strain PCC7518 belongs to the cluster of heterocystous species and has most probably lost the abihty to produce heterocysts by mutation. It is only distantly related to Chlorogloeopsis fritschii PCC67 18. [less ▲]

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See detailLaparoscopic surgery, urology and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailUltrastructural distribution of DNA within the ring-shaped nucleolus of human resting T lymphocytes.
Vandelaer, M.; Thiry, Marc ULg; Goessens, Guy ULg

in Experimental Cell Research (1993), 205(2), 430-2

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The ... [more ▼]

The precise distribution of DNA within the resting human T lymphocyte nucleolus has been investigated, at the ultrastructural level, by cytochemical and molecular immunocytochemical techniques. The nucleolus is partially enveloped by a layer of condensed chromatin which, at several places, penetrates into the nucleolar body until in close contact with the fibrillar centers. Morphometric analysis reveals that 32% of the fibrillar center surface is essentially occupied by condensed chromatin. Using the in situ terminal deoxynucleotidyl transferase-immunogold procedure for detecting DNA, we further show that evident label is exclusively found over the condensed chromatin and over the fibrillar centers, whereas no significant label is detected over the dense fibrillar component of the nucleolus. [less ▲]

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See detailLasfe (CIL IV 2319 l) et quelques autres exemples d’usage abusif de l’épigraphie en phonétique historique
Purnelle, Gérald ULg

in Etudes Classiques (Namur, Belgium) (1993), 61

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See detailCD68 and Factor XIIIa expressions in granular-cell tumor of the skin
Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1993), 186(2), 106-108

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using ... [more ▼]

Immunohistochemical and electron microscopic studies support a Schwann cell origin for most of the granular-cell tumors of the skin. We studied 9 granular-cell tumors by immunohistochemistry, using antibodies to CD68, S-100 proteins, factor XIIIa, L1 antigen, desmin and vimentin. The CD68 monocyte-macrophage-associated lysosomal antigen was expressed in granular cells which however had no Mac 387 reactivity. The 'satellite fibroblasts' were factor XIIIa-positive similarly to dendrocytes and perineurial cells. Our study reveals the lack of specificity of CD68 antibody to identify macrophages. It also presents granular cell tumor of the skin as an exception in the group of schwannomas by the presence of factor XIIIa-positive cells inside the neoplasm. [less ▲]

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See detailRapid and Selective Isolation of Follicular Dendritic Cells by Low Speed Centrifugations on Discontinuous Bsa Gradients
Marcoty, C.; Heinen, Ernst ULg; Antoine, Nadine ULg et al

in Advances in Experimental Medicine and Biology (1993), 329

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