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See detailL'analyse discriminante décisionnelle : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (4), 41

The principles of discriminant analysis are described and illustrated by the iris data set published by Fisher [1936].

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See detailSur philellên chez Cicéron
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

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See detailcompte rendu de : J. Sosephson, The Pahlavi Translation Technique as Illustrated by Hom Yast
Rochette, Bruno ULg

in Translatio (1999), 18(2), 294-297

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See detailStudy of the mechanism of direct laser desorption/ionisation for some small organic molecules (M < 400 daltons)
Benazouz, M.; Hakim, B.; Debrun, J. L. et al

in Rapid Communications in Mass Spectrometry : RCM (1999), 13(23), 2302-2304

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates ... [more ▼]

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates, and a nitrogen laser is used for desorption/ionisation; ion yields are measured with a time-of-flight mass spectrometer, Previous work had shown that ion yields can strongly vary from one substrate to another, and that this variation does not reflect the (calculated) metal surface temperatures. New results obtained in this work indicate that the desorption/ionisation mechanism is linked to the physical state of the substrate surface. Copyright (C) 1999 John Wiley & Sons, Ltd. [less ▲]

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See detailThe DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family.
Fanuel, L; Goffin, Colette ULg; Cheggour, A et al

in Biochemical Journal (1999), 341(Pt 1), 147-55

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are ... [more ▼]

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are utilized as substrates, the enzyme behaves as an aminopeptidase with a preference for N-terminal residues in an l configuration, thus exemplifying an interesting case of stereospecificity reversal. The best-hydrolysed substrate is l-Ala-Gly-Gly, but tetra- and penta-peptides are also efficiently hydrolysed. The gene encodes a 375-residue precursor, but the active enzyme contains two polypeptides corresponding to residues 2-249 (alpha-subunit) and 250-375 (beta-subunit) of the precursor. Residues 249 and 250 are a Gly and a Ser respectively, and various substitutions performed by site-directed mutagenesis result in the production of an uncleaved and inactive protein. The N-terminal Ser residue of the beta-subunit is followed by a hydrophobic peptide, which is predicted to form a beta-strand structure. All these properties strongly suggest that DmpA is an N-terminal amidohydrolase. An exploration of the databases highlights the presence of a number of open reading frames encoding related proteins in various bacterial genomes. Thus DmpA is very probably the prototype of an original family of N-terminal hydrolases. [less ▲]

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See detailAccumulation of glycosidically bound compounds in Fragaria * ananassa cv. Elsanta fruits at various developmental stages.
Groyne, Joëlle; Lognay, Georges ULg; Marlier, Michel

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(1), 5-9

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a ... [more ▼]

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a commercial b-glucosidase and liquidliquid extraction with diethyl ether, on-line coupled capillary gas chromatographic - mass spectrometric (HRGC-MS) identification of the liberated aglycons was achieved. Five developmental stages of strawberry fruit were investigated during ripening. The occurrence and accumulation of glycosides were pointed out and several aglycons were identified in relation with the investigated developmental stages, with a maximum for the overripe fruit. [less ▲]

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See detailOverexpression, purification and characterization of Mycobacterium bovis BCG alcohol dehydrogenase.
Wilkin, J. M.; Soetaert, K.; Stelandre, M. et al

in European Journal of Biochemistry (1999), 262(2), 299-307

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell ... [more ▼]

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell envelope. In this report, the effect of the overexpression of the M. bovis BCG alcohol dehydrogenase (ADH) in Mycobacterium smegmatis and M. bovis BCG is described. The purification of the enzyme was performed to apparent homogeneity from overexpressing M. bovis BCG cells and its kinetic parameters were determined. The enzyme showed a strong preference for both aromatic and aliphatic aldehydes while the corresponding alcohols were processed 100-1000-fold less efficiently. The best kcat/Km values were found with benzaldehyde > 3-methoxybenzaldehyde > octanal > coniferaldehyde. A phylogenetic analysis clearly revealed that the M. bovis BCG ADH together with the ADHs from Bacillus subtilis and Helicobacter pylori formed a sister group of the class C medium-chain alcohol dehydrogenases, the plant cinnamyl alcohol dehydrogenases (CADs). Comparison of the kinetic properties of our ADH with some related class C enzymes indicated that the mycobacterial enzyme substrate profile resembled that of the CADs involved in plant defence rather than those implicated in lignification. A possible role for the M. bovis BCG ADH in the biosynthesis of the lipids composing the mycobacterial cell envelope is proposed. [less ▲]

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See detail"Destinataire final" des subsides cherche privilège, note sous Bruxelles, 1e octobre 1997
Lissoir, Bénédicte ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailLes transferts post-mortem : réinterprétation symbolique du lieu d’enterrement dans un contexte de mobilité des populations
Schmitz, Serge ULg

in Espaces et Sociétés (Paris, France) (1999), 99

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery ... [more ▼]

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery choice. It underlines the connections between post-mortem mobility, the different levels of population mobility and culture. [less ▲]

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See detailAnesthesie generale versus anesthesie perimedullaire.
Murayi, P.; Joris, Jean ULg; Lamy, Maurice ULg

in Revue Médicale de Liège (1999), 54(7), 588-92

Perimedullary anesthetic techniques (epidural or spinal anesthesia), by themselves or combined with general anesthesia offer several advantages in the postoperative period when compared with general ... [more ▼]

Perimedullary anesthetic techniques (epidural or spinal anesthesia), by themselves or combined with general anesthesia offer several advantages in the postoperative period when compared with general anesthesia alone. The incidence of postoperative respiratory and cardiovascular complications is decreased. The physiologic stress reaction, with its associated hypercoagulable state and immune depression, is attenuated. Finally, the resumption of gastrointestinal function is hastened. These benefits of central neural blockade are noted most clearly when the techniques are used for several days postoperatively, most often by catheter based epidural analgesia. The use of local anesthetic agents in the analgesic mixture would appear to be important. This is likely because these substances inhibit the sympathetic nervous system and spinal reflex axes. The role of this inhibition in the advantages of perimedullary techniques is probably important. It is important to note that inhibition of the sympathatetic nervous system can be associated with indesirable consequences in certain patients. These techniques must therefore be used cautiously, and patients who benefit from them must receive careful surveillance. [less ▲]

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See detailLa Société nationale de la Petite Propriété Terrienne, Une institution entre ville et campagne
Mougenot, Catherine ULg

in Cahiers de l'Urbanisme (Les) (1999), (25-26), 42-45

Les maisons « terriennes » font partie de bon nombre de villes et villages. On connait pourtant mal l’origine de ces nombreux quartiers dont l’histoire se fonde dans l’attachement au jardin et la maitrise ... [more ▼]

Les maisons « terriennes » font partie de bon nombre de villes et villages. On connait pourtant mal l’origine de ces nombreux quartiers dont l’histoire se fonde dans l’attachement au jardin et la maitrise d’un environnement proche, un attrait que l’on redécouvre largement aujourd’hui. [less ▲]

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See detailA sharp decrease of resistivity in La0.7Ca0.3Mn0.96Cu0.04O3: Evidence for Cu-assisted coherent tunneling of spin polarons
Sergeenkov, S. A.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 69(11), 858-862

Nearly a 50% decrease of the resistivity rho(T,x) is observed upon just 4% Cu doping at the Mn site of La2/3Ca1/3Mn1-xCuxO3. When the observed phenomenon is attributed to a decrease of the spin-polaron ... [more ▼]

Nearly a 50% decrease of the resistivity rho(T,x) is observed upon just 4% Cu doping at the Mn site of La2/3Ca1/3Mn1-xCuxO3. When the observed phenomenon is attributed to a decrease of the spin-polaron energy E-sigma(x) below T-C(x), all of the data are found to be well fitted by the nonthermal coherent tunneling expression rho(T,x)=rho(0)e(-gamma M2(T,x)), assuming that the magnetization in the ferromagnetic state is given by the expression M(T,x)=M-R(x)+M-0(x)tanh{T-[root(C)(x)/T](2)-1}. The best fits through all the data points suggest M-0(x)similar or equal to root 1-xM(0)(0), M-R(x)similar or equal to x root M-0(0), and E-sigma(x)similar or equal to E-sigma(0)(1-x)(4) for the explicit x dependence of the Cu-induced modifications of the Mn-spin-dominated zero-temperature spontaneous magnetization, residual paramagnetic contribution, and spin-polaron tunneling energy, respectively, with E-sigma(0)=0.12 eV. (C) 1999 American Institute of Physics. [S0021-3640(99)00811-7]. [less ▲]

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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailThe SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory
Hubert, Philippe ULg; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Analytica Chimica Acta (1999), 391(2), 135-148

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data ... [more ▼]

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data evaluation are proposed by an SFSTP Commission dedicated to the validation of chromatographic methods in bioanalysis. In a series of meetings, members of this Commission have tried to elaborate a rational, practical and statistically reliable strategy to assure the quality of the analytical results generated. This strategy has been formalised in a guide and the main suggestions made by the Commission are summarised in the present paper. The SFSTP guide has been produced to help analysts from the pharmaceutical industry to validate their bioanalytical methods, It is the result of a consensus between professionals having expertise in bioanalytical and/or statistical fields. The suggestions presented in this paper should therefore help the analyst to design and perform the minimum number of validation experiments needed to obtain all the required information to establish and demonstrate the reliability of its analytical procedure. The SFSTP guide suggests a validation strategy in two steps: a pre-validation and the validation itself. An experimental design is described for each of these steps and the main aspects discussed in the paper are related to the selection of the most appropriate calibration model to fit experimental data and the most suitable way to determine the limit(s) of quantitation and subsequently the calibration range as well as the optimum number of experiments to be performed in the validation phase. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailLes Formations du Frasnien de la Belgique
Boulvain, Frédéric ULg; Bultynck, P.; Coen, M. et al

in Memoirs of the Geological Survey of Belgium (1999), 44

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See detailbeta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: Relevance to Alzheimer's disease
Pillot, T.; Goethals, M.; Najib, J. et al

in Journal of Neurochemistry (1999), 72(1), 230-7

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously ... [more ▼]

Growing evidence indicates the involvement of apolipoprotein E (apoE) in the development of late-onset and sporadic forms of Alzheimer's disease, although its exact role remains unclear. We previously demonstrated that beta-amyloid peptide (Abeta) displays membrane-destabilizing properties and that only apoE2 and E3 isoforms inhibit these properties. In this study, we clearly demonstrate that the carboxy-terminal lipid-binding domain of apoE (e.g., residues 200-299) is responsible for the Abeta-binding activity of apoE and that this interaction involves pairs of apoE amphipathic alpha-helices. We further demonstrate that Abeta is able to inhibit the association of the C-terminal domain of apoE with lipids due to the formation of Abeta/apoE complexes resistant to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. On the contrary, the amino-terminal receptor-binding domain of apoE (e.g., residues 129-169) is not able to form stable complexes with Abeta. These data extend our understanding of human apoE-dependent binding of Abeta by involving the C-terminal domain of apoE in the efficient formation of apoE/Abeta complex. [less ▲]

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See detailMicroscopic and laser granulometric analyses of hydrating cement suspensions
Lilkov, V.; Dimitrova, E.; Gaydardzhiev, Stoyan ULg

in Cement & Concrete Research (1999), 29

The results from microscopic and laser granulometric analyses of hydrating cement suspensions, containing active mineral additives are presented. Conclusions are drawn about the specific hydration ... [more ▼]

The results from microscopic and laser granulometric analyses of hydrating cement suspensions, containing active mineral additives are presented. Conclusions are drawn about the specific hydration processes of the investigated cements, as well as the applicability of laser granulometry for the study of cement and hydration products. [less ▲]

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See detailCD44v6 expression is an independent prognostic factor in node-negative FIGO stage IB cervical carcinoma.
Speiser, P.; KRIDELKA, Frédéric ULg; Tempfer, C. et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (1999), 9(2), 160-165

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing ... [more ▼]

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing receptor," CD44 is physiologically involved in migration of circulating lymphocytes to lymphatic tissue. In the present study, we investigated the expression of CD44v3 and v6 in 237 patients with stage IB, N0 cervical carcinoma by means of immunohistochemistry. These results were correlated with the GOG score and other prognostic variables. Median follow-up was 82.6 months (39-110 months). Thirty-nine patients recurred and 35 died from disease within the observation period. In univariate analysis, the GOG score, histologic subtype, and CD44v6 expression were statistically significant predictors for poor overall survival (OS). In multivariate (Cox regression) analysis, the GOG score (< 40 vs. 40-120, RR: 1.37 (95% CI: 1.10-1.71); 40-120 vs. > 120, RR: 2.23 (95% CI: 1.28-3.88); P = 0.004), histologic subtype (adenosquamous carcinomas) (RR: 4.56 (95% CI: 1.49-13.92), P = 0.007) and CD44v6 expression (RR: 2.42 (95% CI: 1.14-5.10), P = 0.021) were independent predictors for poor OS. The expression of CD44v3 did not correlate with prognosis. Furthermore we found a strong correlation between CD44v6 expression and lymphovascular space invasion (LVSI) (chi2 = 17.01, P = 0.0001). Tumor expansion into the loco-regional lymphatic system is the preferred way of tumor spread in cervical carcinoma. The strong correlation of CD44v6 with LVSI produces a significant degree of suspicion that cervical carcinoma cells expressing CD44v6 could, by mimicking lymphocytes, exploit their pathways. [less ▲]

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See detailHypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.
Minet, E.; Mottet, Denis ULg; Michel, G. et al

in FEBS Letters (1999), 460(2), 251-6

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear ... [more ▼]

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1alpha fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts with the bHLH-PAS domain of HIF-1alpha. Moreover, Hsp90 is not co-translocated with HIF-1alpha into the nucleus. At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation. [less ▲]

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See detail- Evolution of lipoxygenase activity during storage of potato tubers (Solanum tuberosum L. cv. Bintje)
Fauconnier, Marie-Laure ULg; Koto, N.; Hoyaux, P. et al

in Bulletin de la Société des Sciences de Liège (1999), 68(5-6), 319

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See detailNegative magnetoresistance in mixed-valence La0.6Y0.1Ca0.3MnO3: Evidence for charge localization governed by the Curie-Weiss law
Sergeenkov, S.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 70(2), 141-146

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss ... [more ▼]

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss-dominated transport mechanism in this material both above and below the field-dependent Curie temperature T(C)equivalent to T-0. Attributing this symmetry to strong magnetic fluctuations below T-C (which are triggered by the Y substitution and cause a "bootstrap" destruction of the ferromagnetic phase), the data are interpreted in terms of the nonthermal spin hopping and magnetization-dependent charge carrier localization scenario leading to Delta rho=-rho(s)(1-e(-gamma M2)), with the magnetization M(T,B)=CB/\ T-T-C(B)\(nu). The separate fits through all the data points above and below T-C yield C(+)similar or equal to 2C(-) and nu(+)similar or equal to nu(-)similar or equal to 1, in agreement with the predictions of the Landau mean-field theory. (C) 1999 American Institute of Physics. [S0021-3640(99)01314-6]. [less ▲]

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See detailObservations sous Prés. Com. Bruxelles, 27 avril 1999
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1999)

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See detailUse of Anaesthesia Simulator: Initial Impressions of Its Use in Two Belgian University Centers
Larbuisson, Robert ULg; Pendeville, P.; Nyssen, Anne-Sophie ULg et al

in Acta Anaesthesiologica Belgica (1999), 50(2), 87-93

459 trainees in Anesthesia and Intensive Care Medicine, accompanied by fully certified specialists from several Belgian University Hospital Centers, spend at least a 3 hour session at the Anaesthesia ... [more ▼]

459 trainees in Anesthesia and Intensive Care Medicine, accompanied by fully certified specialists from several Belgian University Hospital Centers, spend at least a 3 hour session at the Anaesthesia Simulator. Each session comprises three segments: the briefing, the simulation session and the debriefing. The use of simulations allows significant individualization of the learning experience. The simulator helps to develop the capacity to understand, explain a phenomenon and to resolve problems. Another important aspect of the use of the simulator involves the trainee's "right to make mistakes". This allows to widen the spectrum of executional situations, and decreases the number of dangerous situations. Two University Centers (ULg and UCL) have each organized simulator sessions despite some differences in their approaches. The simulator is a teaching tool worthy of an obligatory role in the most up-to-date training possible of modern anesthesiologist. This is all the more important given that the current practice of anesthesiology is so complex that any error could cost a human life. [less ▲]

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailLymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis.
Baert, F.; Wouters, K.; D'Haens, G. et al

in Gut (1999), 45(3), 375-81

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical ... [more ▼]

BACKGROUND AND AIMS: It is not known whether lymphocytic colitis and collagenous colitis represent different clinical entities or constitute part of a spectrum of disease. METHODS: Detailed clinical features and histological findings were compared in a large series of patients with confirmed lymphocytic and collagenous colitis. RESULTS: Histological diagnosis was confirmed in 96 patients with collagenous colitis and 80 with lymphocytic colitis. Twenty eight per cent of patients with collagenous colitis and 26% of patients with lymphocytic colitis had overlapping but less pronounced histological features. Both groups were equal in terms of age, use of aspirin and non-steroidal anti-inflammatory drugs, associated autoimmune conditions, arthritis, diarrhoea, and abdominal pain. The male:female ratio was 27:73 for collagenous colitis and 45:55 for lymphocytic colitis (p=0.013). Twenty five per cent of patients with collagenous colitis compared with 14% of patients with lymphocytic colitis were active smokers; only 8.3% of patients with collagenous colitis had stopped smoking compared with 23% of patients with lymphocytic colitis (p=0.013). Drug induced disease was suspected for ticlopidine (two collagenous colitis, four lymphocytic colitis) and flutamide (four lymphocytic colitis). Mean duration of symptoms before diagnosis was two months for lymphocytic colitis and four months for collagenous colitis. Overall prognosis was generally mild; 84% of patients with lymphocytic colitis and 74% of patients with collagenous colitis reported resolution or significant improvement (p=0.033). CONCLUSIONS: Collagenous and lymphocytic colitis are similar but not identical. Patients with lymphocytic colitis present somewhat earlier and are less likely to be active smokers. Symptoms are milder and more likely to disappear in lymphocytic colitis. Ticlopidine and flutamide should be added to the list of drugs inducing colitis. [less ▲]

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See detailLes conditions de la rentabilité de la production d'embryons bovins par ponction folliculaire échoguidée et fécondation in vitro en Région Wallonne : première approche.
Dehareng, D.; Annet, C.; Dupont, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailModelling the propagation pathway of street-traffic noise : practical comparison of German guidelines and real-world measurements
Wetzel, Edgar; Nicolas, Jacques ULg; Andre, Philippe ULg et al

in Applied Acoustics (1999), 57(2), 97-107

In Germany, several guidelines were developed to model the noise propagation pathway. The study compares the guidelines DIN 18005, RLS-90 and VDI 2714, all of which provide some kind of sound object line ... [more ▼]

In Germany, several guidelines were developed to model the noise propagation pathway. The study compares the guidelines DIN 18005, RLS-90 and VDI 2714, all of which provide some kind of sound object line source suited to model street traffic noise. Differences between those guidelines are explained, and their effect on practical calculations is shown in a real-world situation, National Road N4, in Arlon, Belgium. Calculated results are compared to measurements made on critical points along the road. The paper emphasises the understanding of the inner workings of models. In order to avoid differences in calculated results due to software design methods applied, all calculations are made using one single commercially available simulation program. Additionally, this allows for a test of guideline sensitivity to changes in input parameters. [less ▲]

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See detailSème inhérent et sème afférent. Examen des critères théoriques dans la sémantique interprétative de François Rastier
Badir, Sémir ULg

in Travaux de linguistique : revue internationale de linguistique Française (1999), 38

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques ... [more ▼]

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques critères théoriques relatifs à la détermination des différents types de sèmes (sème inhérent et sème afférent; sème spécifique et sème générique). On s’attache ici d’abord à montrer que ces critères, en dépit de leurs points d’ancrage dans la théorie structurale, ne sont pas définis de manière satisfaisante par François Rastier, initiateur et théoricien de cette sémantique. Puis on propose, au moins à titre d’hypothèse théorique dépourvue de contradiction, une nouvelle formulation des critères distinctifs des sèmes. [less ▲]

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See detailCerebral metabolism during vegetative state and after recovery to consciousness
Laureys, Steven ULg; Lemaire, Christian ULg; Maquet, Pierre ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (1999), 67(1), 121-122

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See detailAbsence of response to early transcranial magnetic stimulation in ischemic stroke patients: prognostic value for hand motor recovery.
Pennisi, Giovanni; Rapisarda, Giuseppe; Bella, R. et al

in Stroke (1999), 30(12), 2666-70

BACKGROUND AND PURPOSE: Transcranial magnetic stimulation (TMS) has been proposed as a prognostic tool in stroke patients. Most of the previous studies agree in considering the presence of motor-evoked ... [more ▼]

BACKGROUND AND PURPOSE: Transcranial magnetic stimulation (TMS) has been proposed as a prognostic tool in stroke patients. Most of the previous studies agree in considering the presence of motor-evoked potentials (MEPs) in the first days after a stroke as an indicator of good outcome. In the present study, we have assessed the prognostic value of the absence of response to early TMS on hand motor recovery in stroke patients with complete hand palsy at onset due to ischemia in the area of the middle cerebral artery. METHODS: Fifteen patients submitted to TMS within 48 hours of stroke onset (defined as day 1) and again after 1 year. They were also evaluated clinically on day 1 by a scale derived from the Medical Research Council (MRC) and by the National Institutes of Health (NIH) stroke scale; they were reevaluated by the same scales and by Barthel Index on day 365. RESULTS: On day 1, all the patients had complete hand palsy and no response to TMS; their NIH scores showed great variability. After 1 year, 6 of 15 patients regained small and prolonged MEPs, together with a very poor and not functionally useful motor recovery. NIH scores were significantly improved. Barthel Index scores showed large interindividual differences and were not correlated with MRC scores. CONCLUSIONS: We conclude that in patients with complete hand palsy, the absence of response to TMS in the first hours is predictive of absent or very poor, not useful, hand motor recovery. [less ▲]

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See detailClinical Activity and Benefit of Irinotecan (CPT-11) in Patients with Colorectal Cancer Truly Resistant to 5-Fluorouracil (5-FU)
Van Cutsem, Eric; Cunningham, D.; Ten Bokkel Huinink, W. W. et al

in European Journal of Cancer (1999), 35

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See detailModélisation spatiale de la sélection de l'habitat chez le Blaireau européen (Meles meles) au moyen d'un Système d'Information Géographique.
Vanhalle, L.; Defourny, P.; Dufrêne, Marc ULg

in Cahiers des Réserves Naturelles -Rnob (1999), 13

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See detailLes adénovirus recombinants comme vecteurs vaccinaux
Gogev, S.; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1999), 143

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See detailQuête de reliques en Sardaigne pour le prieuré Saint-Léonard de Liège (1642-1650)
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1999)

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See detailLa transmission du virus de l’hépatite C en milieu hospitalier
Delwaide, Jean ULg; Gerard, Christiane ULg; Belaiche, Jacques ULg et al

in Médecine et Hygiène (1999), 57

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See detailPseudoscalar vertex, Goldstone boson and quark masses on the lattice
Cudell, Jean-René ULg; Le Yaouanc, A.; Pittori, Carlotta

in Physics Letters B (1999), 454

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See detailL'homeopathie est-elle superieure au placebo? Controverse a propos d'une meta-analyse des etudes controlees.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(7-9), 295-304304-7

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not ... [more ▼]

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not rely on any scientific basis, it appears to be popular, especially in general practice. The homeopaths have recently taken arguments from a meta-analysis published in 1997 in the Lancet of 89 placebo-controlled trials. This study indeed concluded that the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo. However, this meta-analysis contains several methodological flaws. Furthermore, it is recognized that results of a meta-analysis may not be confirmed in large well-performed clinical trials. Thus, homeopathy should still provide the evidence that conventional medicine has regularly brought during the last two decades in many fields of therapeutics, with the respect of the rigorous rules of "Good Clinical Practice", leading to "Evidence-Based Medicine". [less ▲]

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See detailStructure of high temperature fluid selenium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Journal of Non-Crystalline Solids (1999), 250-252

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures ... [more ▼]

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures obtained are in agreement with the X-ray scattering and extended X-ray absorption fine structure (EXAFS) data in a range of temperatures and densities. A correlation between the conductivity of high temperature fluid selenium and the degree of branching and breaking of the selenium chains is observed [less ▲]

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See detailInfo-congres. L'etude HOPE: demonstration de la protection cardio-vasculaire du ramipril, un inhibiteur de l'enzyme de conversion de l'angiotensine.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(10), 835-6

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study were presented at the XXIst Congress of the European Society of Cardiology in Barcelona (August 28-September 1, 1999). In addition ... [more ▼]

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study were presented at the XXIst Congress of the European Society of Cardiology in Barcelona (August 28-September 1, 1999). In addition, results obtained in the large diabetic sub-population (38% of the 9541 patients included in the trial) were reported at the XXXVth Congress of the European Association for the Study of Diabetes in Brussels (September 28-October 2, 1999). The HOPE trial was terminated early because of a reduction of the relative risk (-22%, p < 0.000002) of major cardiovascular events in the group treated with ramipiril compared to the group receiving placebo. Such a favourable effect of ramipril was observed in non-diabetic subjects in secondary prevention and in diabetic patients in secondary or primary prevention. In the latter population, a significant reduction in the incidence of microangiopathic complications (nephropathy and retinopathy) was also demonstrated. [less ▲]

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See detailThe Indotriradites dolianitii Morphon, a distinctive group of miospore species from the Lower Carboniferous of Gondwana.
Loboziak; Melo, J.H.G.; Playford, G et al

in Review of Palaeobotany and Palynology (1999), 107

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See detailCompte rendu de J. VERGER, La renaissance du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1999)

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See detailL'etude clinique du mois. Interet d'augmenter un taux de cholesterol HDL bas en prevention secondaire de la coronaropathie: resultats de l'etude VA-HIT.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(9), 773-5

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary ... [more ▼]

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary prevention of coronary heart disease. It demonstrates that a fibrate treatment (gemfibrozil) significantly reduces the relative risk of major coronary (-22%, p = 0.006) and cardiovascular (-24%, p < 0.001) events in men with coronary heart disease whose primary lipid abnormality is a low HDL cholesterol level. These findings suggest that, in such a population, the rate of coronary events is reduced under gemfibrozil therapy by raising HDL cholesterol levels (+6%) and lowering levels of triglycerides (-31%) without lowering LDL cholesterol concentrations. [less ▲]

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailMedicaments et grossesse.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(5), 409-14

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the ... [more ▼]

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the public as well as among medical doctors. However, the complexity of the problem, the lack of robust scientific data and the emotional context characterizing this period make the prescription of medications to a pregnant woman a difficult task for every people involved in health care, the pharmacist, the general practitioner and even the gynaecologist. [less ▲]

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See detailGEQUAC, an excess Gibbs energy model describing associating and non-associating liquid mixtures by a new model concept for functional groups
Egner, Katja; Gaube, Johann; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1999), 158(381-389),

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See detailLes etudes cliniques controlees, support incontournable de la medecine basee sur l'evidence.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(1), 1

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See detailL'obligation naturelle du père biologique de fournir des aliments à son enfant. Note sous Liège, 15 juin 1998
Genicot, Gilles ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailChanges in endothermic transitions associated with light-induced chlorophyllide formation, as investigated by differential scanning calorimetry
Mysliwa-Kurdziel, B.; Franck, Fabrice ULg; Chahdi, M. A. O. et al

in Physiologia Plantarum (1999), 107(2), 230-239

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC ... [more ▼]

The changes in thermal transitions associated with protochlorophyllide (Pchlide) into chlorophyllide (Chlide) phototransformation were investigated using sensitive differential scanning calorimetry (DSC), Two groups of endothermic transitions, each composed of several components, were observed between 25 and 90 degrees C for prolamellar body (PLB) membranes isolated from etiolated wheat (Triticum aestivum) leaves. The first group, located in the 20-45 degrees C region, was strongly affected by a short light pulse given prior to measurement, A decrease of this group of transitions was observed shortly after illumination and it was hardly detected in PLBs measured after the Chlide Shibata shift. Calorimetric results were supported by 77-K fluorescence emission spectra measured for continuously heated samples at different temperatures. We interpreted the DSC band observed between 20 and 45 degrees C as due to the disaggregation of Pchlide- (or Chlide-)-reductase-NADPH complexes, More detailed analysis using Gaussian deconvolution showed that this band was composed of three transitions at 32, 39 and 41 degrees C. The second group of transitions was detected in the 45-80 degrees C region, the same as for mature thylakoids. Its main component at 60 degrees C was not affected significantly by a short light pulse. By comparison of thermograms obtained for PLBs with those for mature thylakoid membranes, this transition was identified as the ATPase denaturation band. [less ▲]

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See detailA scintigraphic study of post-massage blood flow in human lower limb
Vanderthommen, Marc ULg; Depresseux, J.C.; Dauchat, L. et al

in European Journal of Physical Medicine & Rehabilitation (1999), 8(6), 159-162

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See detailDepressive vulnerability is not an independent risk factor for osteoporosis in postmenopausal women.
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Paul, I. et al

in Maturitas (1999), 33(2), 133-7

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy ... [more ▼]

Major depression has been repeatedly but not consistently reported to be associated with low bone mineral density (BMD) and to an increased risk for fracture in women. We have investigated, in healthy postmenopausal women, whether depressive symptomatology, assessed by the General Health Questionnaire (GHQ), was associated to a significant decrease in BMD, hence supporting the hypothesis of an independent pathogenetic link between the two disorders. We investigated 121 postmenopausal women, aged 48-77 years, spontaneously attending a screening visit for osteoporosis in an outpatient facility. BMD of the spine and the non-dominant hip (total and neck areas) were measured by Dual Energy X-Ray absorptiometry. All subjects completed to the 'General Health Questionnaire' translated and validated in French. No significant correlations were observed between the GHQ score and BMD of the spine (P = 0.54), the total hip area (P = 0.65), or the femoral neck area (P = 0.65). No differences in terms of spinal or femoral BMD were observed between women with GHQ score < 5 or > or = 5. When comparing values of BMD between women within the upper and the lower quartiles for GHQ score, no difference was observed for spine (P = 0.69), total hip (P = 0.80), or femoral neck (P = 0.93). Similarly, GHQ scores were not significantly different when comparing women in the upper and lower quartiles of BMD distribution at the spine or the hip. In conclusion, notwithstanding the clinical pattern of postmenopausal osteoporosis can lead to depression and, on the other hand, hormonal and behavioral disturbances reported in depression might be enhancing factors for accelerated bone loss, our present results do not support the hypothesis that otherwise healthy postmenopausal women with increased depressive complaints are also more prone to exhibit osteoporotic fractures. [less ▲]

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See detailPerturbative evolution and Regge behaviour
Cudell, Jean-René ULg; Donnachie, A.; Landshoff, P. V.

in Physics Letters B (1999), 448

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See detailValidation of an automated method for the liquid chromatographic determination of atenolol in plasma: application of a new validation protocol
Chiap, Patrice ULg; Hubert, Philippe ULg; Boulanger, Bruno ULg et al

in Analytica Chimica Acta (1999), 391(2), 227-238

In order to test the applicability of a new strategy by a Commission of the Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) for the validation of bioanalytical methods, an automated ... [more ▼]

In order to test the applicability of a new strategy by a Commission of the Societe Francaise des Sciences et Techniques Pharmaceutiques (SFSTP) for the validation of bioanalytical methods, an automated method was developed for the determination of atenolol in human plasma. This method was based on the use of dialysis as sample purification step, followed by enrichment of the dialysate on a precolumn and liquid chromatographic analysis. All sample handling operations were carried out automatically by means of an ASTED system. Atenolol and its internal standard (sotalol) were separated on a C-8 column with a mixture of pH 7.0 phosphate buffer containing 1-octanesulphonate and methanol (81/19; v:v) as mobile phase and monitored photometrically at 225 nm. The validation strategy comprises two steps. The experiments performed during the first step, the so called pre-validation step, have permitted the selection of the most appropriate model for the calibration curve by means of a decision tree, i.e. a least squares regression model obtained after transformation of data (square root in this case), the estimation of the limit of quantitation at 25 ng/ml by means of an accuracy profile, the determination of the calibration range (from 25 to 1000 ng/ml), the estimation of the limit of detection at 9 ng/ml and the calculation of the mean extraction efficiency (about 65%). The second step is the validation itself, comprising the evaluation of method selectivity towards endogenous components, the confirmation of the limit of quantitation, the verification of linearity and the assessment of method precision (repeatability and intermediate precision) as well as accuracy using quality control samples at different concentration levels over the range investigated. The relative standard deviation values for repeatability and intermediate precision were between 2.7% and 9.0%. Moreover, the method was found to be accurate. Indeed, the 95% one-sided confidence limits of the mean recovery did not exceed the acceptance limits of 80% and 120%. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailL'esthéticien
Steinmetz, Rudy ULg

in Art&Fact (1999)

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See detailNovel macromolecular architectures based on aliphatic polyesters: relevance of the "coordination-insertion" ring-opening polymerization
Mecerreyes, David; Jérôme, Robert ULg; Dubois, Philippe ULg

in Advances in Polymer Science (1999), 147

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e ... [more ▼]

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e., lactones, lactides, glycolide, is introduced. An insight into this so-called "coordination-insertion" mechanism and the ability of this living polymerization process to prepare well-defined homopolymers, telechelic polymers, random and block copolymers is then discussed. In the second part, the combination of the living ROP of (di)lac-tones with other well-controlled polymerization mechanisms such as anionic, cationic, free radical, and metathesis polyadditions of unsaturated comonomers, as well as polyconden-sations, is reported with special emphasis on the design of new and well-tailored macromolecular architectures. As a result of the above synthetic breakthrough, a variety of novel materials have been developed with versatile applications in very different fields such as biomedical and microelectronics. [less ▲]

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See detailLes formes et les titulaires de la faculté prévue par l'article 1421 du Code judiciaire
Boularbah, Hakim ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (1999)

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See detailEGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
Du, G.; Willet, K.; Mouithys-Mickalad, Ange ULg et al

in Free Radical Biology & Medicine (1999), 27

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to ... [more ▼]

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to impair respiratory activities and mitochondrial oxidative phosphorylation efficiency. ADP/O (2.57 +/- 0.11) decreased after anoxia/reoxygenation (1.75 +/- 0.09, p < .01), as well as state 3 and uncoupled respiration (-20%, p < .01), but state 4 respiration increased (p < .01). EGb 761 (50-200 microg/ml) had no effect on mitochondrial functions before anoxia, but had a specific dose-dependent protective effect after anoxia/reoxygenation. When mitochondria were incubated with 200 microg/ml EGb 761, they showed an increase in ADP/O (2.09 +/- 0.14, p < .05) and a decrease in state 4 respiration (-22%) after anoxia/reoxygenation. In EPR spin-trapping measurement, EGb 761 decreased the EPR signal of superoxide anion produced during reoxygenation. In conclusion, EGb 761 specially protects mitochondrial ATP synthesis against anoxia/reoxygenation injury by scavenging the superoxide anion generated by mitochondria [less ▲]

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See detailIncreased number of hip fractures.
Gillet, Pierre ULg; Reginster, Jean-Yves ULg

in Lancet (1999), 353(9170), 2160-1

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See detailA critical compilation and extended analysis of the Ne IV spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete ... [more ▼]

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete and consistent up-to-date tables of spectral lines and energy levels, particularly of the neon-ions spectra, notably reduces possibilities of interpretation of astrophysical and laboratory spectra. In the present paper, all optical spectral lines of Ne IV observed in 24 previous works have been systematised together with recent observations made by means of the beam-foil method at Liège University. As a result of our extended analysis of the whole set of available data, 35 new energy levels have been found and 90 newly classi ed spectral lines have been listed for the Ne IV spectrum, only a few of them having been reported previously. A complete table of observed and classi ed spectral lines has been built, and the list of optimised energy levels has been derived from it in a consistent way. A new, improved, ionisation potential of Ne IV has been deduced from the experimental data. [less ▲]

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See detailL'opposition à mariage doit être confinée dans des limites strictes. Note sous Civ. Bruxelles, 24 septembre 1997
Genicot, Gilles ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailEvaluer et rééduquer les difficultés morpho-syntaxiques chez le jeune enfant : Du geste au langage
Comblain, Annick ULg

in Bulletin d'Audiophonologie (1999), 15(2), 223-236

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une ... [more ▼]

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une petite dizaine d’années s’écoulent. Pour 7 à 8 % des enfants, le langage va se développer plus lentement et plus laborieusement et pour 1%, le retard sera sévère et persistant en dehors de toute prise en charge logopédique spécifique. Chez ces enfants en difficultés d’apprentissage du langage, les aspects morphosyntaxiques de la langue restent une difficulté majeure et une pierre d’achoppement non négligeable dans le processus de rééducation. Il est donc crucial dans une démarche d’évaluation du langage d’évaluer cette composante langagière de manière complète et précise de manière à, d’une part poser un diagnostic fiable et quantifier l’ampleur du retard et des troubles de développement, et, d’autre part, à fixer avec le plus d’exactitude et de minutie possible les objectifs d’une rééducation. [less ▲]

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See detailLa leçon des choses. Robinson ou la répétition
Durand, Pascal ULg

in Etudes Françaises (1999), 35/1

Roman à ce point connu qu'il n'est plus guère lu, texte tronqué parce que trop réécrit, Robinson Crusoe tire peut-être bien de tout ce que Rousseau appelait son « fatras » l'essentiel de sa signification ... [more ▼]

Roman à ce point connu qu'il n'est plus guère lu, texte tronqué parce que trop réécrit, Robinson Crusoe tire peut-être bien de tout ce que Rousseau appelait son « fatras » l'essentiel de sa signification. Actes rituels, besognes et constructions, plaintes et méditations, prières et prêchi-prêcha font de ce texte un roman de la répétition dans lequel un héros calculateur soumet les objets divers qui l'environnent à une comptabilité compulsive. La leçon des choses est trompeuse : le principe d'utilité qu'elles proclament masque assez mal qu'elles restent prises, aux yeux de Robinson, dans la logique marchande qu'elles semblaient suspendre. [less ▲]

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See detailEtude rétrospective de l'incidence des troubles nereux rapportés et suspects d'encéphalopathie spongiforme transmissible chez les bovins en Belgique
Saegerman, Claude ULg; Claes, M.; Vanopdenbosch, E. et al

in Epidémiologie et Santé Animale (1999), 35

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See detailEffect of synthesis process and substrate on electrical and thermal transport properties of Bi-2212
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Bougrine, Hassan ULg et al

in Journal of Superconductivity (1999), 12(5), 623-629

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade ... [more ▼]

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade BaZrO3 substrate. Those measurements show that the BaZrO3 substrate gives better superconducting properties to the Bi-2212 than the Al2O3 substrate. The effect of (1.0 T) weak magnetic field has been searched for. The thermal magnetoconductivity and the contributions of the magnetic field to the thermoelectrical power are studied and compared through fine measurements. An electronic contribution seems to appear already well above the critical temperature and to exist up to 200 degrees K. The onset temperature is thus deduced. [less ▲]

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See detailEffective resolution of racemic pirlindole at the preparative scale
De Tullio, Pascal ULg; Ceccato, A.; Liégeois, Jean-François ULg et al

in Chirality (1999), 11

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See detailImpact of dolomite lime on the ground vegetation and on potential net N transformations in Norway spruce (Picea Abies (L.) Karst.) and sessile oak (Quercus Petraea (Matt.) Lieb.) stands in the Belgian Ardenne
Duliere, J.-F.; Carnol, Monique ULg; Dalem, S. et al

in Annals of Forest Science : a Multidisciplinary and International Journal (1999), 56

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst ... [more ▼]

The impact of dolomite lime (5 T·ha-1) on the ground vegetation and on potential net nitrogen (N) transformations was investigated in two Belgian forest ecosystems. Norway spruce (Picea abies (L.) Karst.) and sessile oak (Quercus petraea (Matt.) Lieb.) stands were situated in the Haute Ardenne (east Belgium) on acid-brown soil. The herb-layer floristic richness increased during the 2 years following liming, with the appearance of light and N-demanding species, which are also found in clear-cut areas or on road verges. Mosses reacted rapidly, showing a decrease acidophilous-dominant species and the establishment of some ruderal species. Six months after liming, the pH was significantly increased in the organic horizon of both stands and in the organomineral horizon of the oak stand. Soils originating from the two stands showed distinct responses in net NO3- production to the dolomite lime treatment. In the organic layer of the Quercus soil, net NH4+ production was decreased, NO3- production increased, and total N mineralisation remained unchanged. In the organomineral layer, NO3 - production was increased. In the Picea soil, NO3 - production was decreased in the organomineral soil layer. These results indicate the possibility of differences in the control of the N transformation processes occurring in the two sites. [less ▲]

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See detailAre The Fusion Processes Involved In Birth, Life And Death Of The Cell Depending On Tilted Insertion Of Peptides Into Membranes?
Peuvot, J.; Schanck, A.; Lins, Laurence ULg et al

in Journal of Theoretical Biology (1999), 198(2), 173-81

Various peptide segments have been modeled as asymmetric amphipathic alpha-helices. Theoretical calculations have shown that they insert obliquely into model membranes. They have been named "tilted ... [more ▼]

Various peptide segments have been modeled as asymmetric amphipathic alpha-helices. Theoretical calculations have shown that they insert obliquely into model membranes. They have been named "tilted peptides". Molecular modeling results reported here also evidence the presence of tilted peptides in ADM-1 protein of Caenorhabditis elegans that may be involved in fusion events, in meltrin alpha, a protein implicated in myoblast fusion, in hemagglutinin of influenza virus, in the E2 glycoprotein of rubella virus, in the S protein of hepatitis B virus, in a subdomain of Ebola virus and in the malaria CS protein. Experimental results have indicated that tilted peptide fragments may be involved in cellular life events like sperm-egg fecondation, muscle development, protein translocation through signal sequences and cellular death caused by viral infection or parasite infestation. We speculate that membrane destabilization by these tilted peptides may be an important common step in life processes involving fusion phenomena. [less ▲]

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See detailRecombinant Production Of The P10(Cks1at) Protein From Arabidopsis Thaliana And C-13 And N-15 Double-Isotopic Enrichment For Nmr Studies
Landrieu, I.; Casteels, P.; Odaert, B. et al

in Protein Expression & Purification (1999), 16(1),

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See detailPCAM: a multi-user facility-based protein crystallization apparatus for microgravity
Carter, Daniel; Wright, Brenda; Miller, Teresa et al

in Journal of Crystal Growth (1999), 196

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of ... [more ▼]

A facility-based protein crystallization apparatus for microgravity (PCAM) has been constructed and flown on a series of Space Shuttle Missions. The hardware development was undertaken largely because of the many important examples of quality improvements gained from crystal growth in the diffusion-limited environment in space. The concept was based on the adaptation for microgravity of a commonly available crystallization tray to increase sample density, to facilitate co-investigator participation and to improve flight logistics and handling. A co-investigator group representing scientists from industry, academia, and government laboratories has been established. Microgravity applications of the hardware have produced improvements in a number of structure-based crystallographic studies and include examples of enabling research. Additionally, the facility has been used to support fundamental research in protein crystal growth which has delineated factors contributing to the effect of microgravity on the growth and quality of protein crystals. [less ▲]

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See detailCharacterization of YKL165c a new essential gene of the yeast Saccharomyces cerevisiae.
Delbecq, Xavier; Godrie, Thérèse ULg; Portetelle, Daniel ULg et al

in Archives Internationales de Physiologie et de Biochimie (1999), 107

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See detailLe sémioticien
Durand, Pascal ULg

in Art&Fact (1999), (18), 81-82

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See detailLes aliments industriels chez les carnivores domestiques : III. L'alimentation des chiens de grande race en croissance.
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

Actually the number of pet foods for growing dogs is increasing, so that the choice is becoming more and more difficult. The specific feeding of puppies of large and giant breeds is documented in many ... [more ▼]

Actually the number of pet foods for growing dogs is increasing, so that the choice is becoming more and more difficult. The specific feeding of puppies of large and giant breeds is documented in many studies. The aim of the present paper is to summarise the main studies related to skeletal disorders in the growing dog in order to avoid feeding errors by the practitioner. The requirements of the growing dogs are reviewed along with the development of the main orthopaedic diseases. Then the nutrients to be taken into consideration in the feeding of the growing dogs are discussed. Finally a comparison between different pet foods for growing dog shows a largely variable composition. Practical applications are made to compare the nutrient supplies from different foods to dogs of medium and large breeds. [less ▲]

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See detailAnionic synthesis of [1,4-poly(diene)-b-syndiotactic poly(methyl methacrylate)] diblock copolymers: 7Li NMR study of the intermediate reaction of lithium poly(diene) anion with 1,1-diphenylethylene
Zune, Catherine; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecular Chemistry and Physics (1999), 200(2), 460-467

The end-capping with 1,1-diphenylethylene (DPE) of living 1,4-poly(diene) lithiated anions prepared in cyclohexane (Chx) and toluene is a major but poorly controlled step in the synthesis of syndiotactic ... [more ▼]

The end-capping with 1,1-diphenylethylene (DPE) of living 1,4-poly(diene) lithiated anions prepared in cyclohexane (Chx) and toluene is a major but poorly controlled step in the synthesis of syndiotactic poly(methyl methacrylate) (sPMMA) containing block copolymers. The kinetics of the reaction have been studied by means of 7Li NMR not only in Chx and toluene but also in their mixtures with polar solvents, since the solvent polarity must be increased for MMA to be predominantly converted into sPMMA. Although the addition of a polar solvent (tetrahydrofuran (THF), diethyl ether) to Chx and toluene is known to increase the reactivity of living polymeric anions, contaminating lithium salts, such as lithium hydroxide, slow down the end-capping reaction even when 10 vol.-% polar solvent is added. Moreover, the polymeric diphenylalkyllithium anions are unstable in 1/9 (v/v) THF/Chx mixture, as a result of the nucleophilic attack of THF. On the basis of all these observations, new experimental conditions are proposed for improving the control of the anionic block copolymerization of 1,3-dienes and MMA to yield 1,4-poly(diene) and sPMMA containing block copolymers. [less ▲]

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See detailGerhard Herzberg (1904-1999)
Biémont, Emile ULg; Dubois, I.

in Annuaire Cl. Sc. Acad. Roy. (1999), X

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See detailThe deformation of the Egersund-Ogna anorthosite massif, south Norway: finite-element modelling of diapirism
Barnichon, Jean-Dominique; Havenith, Hans-Balder ULg; Hoffer, Benoit et al

in Tectonophysics (1999), 303(1-4), 109-130

This paper aims at testing the mechanical relevance of the petrological model of anorthosite massif diapiric emplacement. The Egersund-Ogna massif (S. Norway) is of particular interest because recent ... [more ▼]

This paper aims at testing the mechanical relevance of the petrological model of anorthosite massif diapiric emplacement. The Egersund-Ogna massif (S. Norway) is of particular interest because recent petrological and geochronological data constrain the initial geometry, emplacement conditions and timing (about 2 m.y.). The formation of this anorthosite massif is in agreement with the classical petrological model, in which accumulation of plagioclase takes place in a deep-seated magma chamber at the crust-mantle limit, from which masses of plagioclase separate and rise through the lower crust up to the final level of emplacement at mid-crustal depths. The Egersund-Ogna massif also displays a foliated inner margin, in which strain ellipsoids have been reconstructed by investigating at 51 sites the deformation of megacrysts of high-alumina orthopyroxene. Based on these petrological data, a model made up of one rigid layer (upper granitic crust) and three viscous layers (lower part of the granitic crust, noritic lower crust and anorthosite) has been built up. The upper crust behaviour is represented by an elastoplastic law and the viscous layers obey elastic-viscoplastic laws with Newtonian viscosity. An inverse density gradient is considered between the lower crust (d = 3.00) and the anorthosite (d = 2.75), the loading consisting only in gravity. The modelling is carried out under axisymmetrical conditions, using the LAGAMINE finite-element code coupled with an automatic re-meshing algorithm designed to deal with large strains in complex structures. The results show that, from a mechanical point of view, the diapirism model is a robust and consistent assumption for the emplacement of anorthosites, because realistic diapir and rim-syncline shapes are obtained. Moreover, the numerically obtained emplacement time (about 2.5 m.y.) is in agreement with the available geochronological data, and the computed strain field is coherent with field measurements, especially regarding the circumferential extension, which becomes the largest extension strain component in the expansion phase. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLes aliments industriels chez les carnivores domestiques : II. Choix des ingrédients et application aux aliments "Premium"
Derua, N.; Istasse, Louis ULg; Diez, Marianne ULg

in Annales de Médecine Vétérinaire (1999), 143

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ... [more ▼]

Over the last 10 years the number of premium foods is increasing in the petfood industry for companion animals. It is often difficult for the vets in practice to compare different premium foods. The ingredients sources used in diet formulation remain a criterion to indirectly evaluate the quality. A judicious choice of feedstuffs directly influences palatability and digestibility of each diet. The present paper aims to describe the different nutrient sources used in the premium foods industry. Each nutrient and its sources are presented separately starting by protein, fat and carbohydrates and ending with vitamins and minerals. Labelling according to the offical recommandations is also reported. [less ▲]

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See detailConfirmation and disconfirmation : Their social advantages
Leyens, J. P.; Dardenne, Benoît ULg; Yzerbyt, V. et al

in European Review of Social Psychology (1999)

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See detailA comparison of advanced thermal cycles suitable for upgrading existing power plant
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Applied Thermal Engineering (1999), 19(3), 227-237

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants ... [more ▼]

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants using fossil fuels. Highly efficient cycles are available : gas turbines combined with waste heat boilers and steam cycles are able to achieve efficiencies above 50-55%. However building new plants requires a large amount of capital. Alternative proposals are based on upgrades of existing plants : capital savings are expected by reusing part of the facilities. In the present study, three parallel proposals are compared on the basis of exergy efficiency; cost of investment and flexibility of operation are also discussed. They are compared with classical Rankine cycle and state of the art combined cycles. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailThe mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse
Schurmans, Stéphane ULg; Carrio, R.; Behrens, J. et al

in Genomics (1999), 62

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic ... [more ▼]

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic domain, and a 3' proline-rich region. Recent results suggest that SHIP2 and SHIP1 act downstream of various receptors by removing a phosphate from the 5' position of the phosphatidylinositol 3'-kinase phosphatidylinositol 3,4, 5-triphosphate product and of inositol 1,3,4,5-tetrakisphosphate. Human SHIP2 is highly expressed in adult heart, skeletal muscle, and placenta, whereas SHIP1 expression is limited to the hematopoietic system. We report here the molecular analysis of the mouse SHIP2 cDNA and the corresponding protein, the structure of the gene, and the identification of its promoter. SHIP2 mRNA expression was analyzed in embryonic and adult mouse tissues by reverse transcription-polymerase chain reaction and in situ hybridization. In embryonic day 15.5 mice, SHIP2 was strongly expressed in the liver, specific regions of the central nervous system, the thymus, the lung, and the cartilage perichondrium. In adult mice, SHIP2 mRNA was markedly present in the brain and the thymus and at different stages of spermatozoa maturation in the seminiferous tubules. The subtle differences in the protein structure of SHIP2 and SHIP1 as well as their different patterns of expression are discussed [less ▲]

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See detailConvergence of High Order Curl-Conforming Finite Elements
Geuzaine, Christophe ULg; Meys, B.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1442--1445

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See detailOn the use of the Cowan's code for atomic structure calculations in singly ionized lanthanides
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Journal of Quantitative Spectroscopy & Radiative Transfer (1999), 62

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See detailA Natural Method for Coupling Magnetodynamic H-Formulations and Circuit Equations
Dular, Patrick ULg; Geuzaine, Christophe ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (1999), 35(3), 1626--1629

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See detailEndometrial laser intrauterine thermo-therapy (ELITT™): a revolutionary new approach to the elimination of menorrhagia
Donnez, Jacques; Polet, Roland; Squifflet, Jean et al

in Current Opinion in Obstetrics & Gynecology (1999), 11(4), 363-70

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is ... [more ▼]

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is low-dose laser radiation of the endometrium with the diode source, which is characterized by the highest incidence of amenorrhea. [less ▲]

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See detailLe controle thérapeutique des médicaments antidépresseurs
Charlier, Corinne ULg; Ansseau, Marc ULg; Pinto, Emmanuel ULg et al

in Annales de Biologie Clinique (1999), 57(4, Jul-Aug), 463-8

Depression is a pathology frequently observed in general medicine (10%). Treatment of depression makes great use of drugs from different pharmacological classes. The optimal posology is difficult to ... [more ▼]

Depression is a pathology frequently observed in general medicine (10%). Treatment of depression makes great use of drugs from different pharmacological classes. The optimal posology is difficult to establish, and clinicians prefer to avoid side effects by prescribing low regimen. This study is related to an evaluation of seric antidepressant concentrations in comparison with the daily doses in a large psychiatric population. Side effects of drugs are appreciated by enzymatic determinations. [less ▲]

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See detailDevelopment of a coupled flow and transport 3D model for simulating seawater intrusions in coastal aquifers
Carabin, Guy; Dassargues, Alain ULg

in Natuurwetenschappelijk Tijdschrift (1999), 79

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See detailHypo- et hypertension intracrâniennes bénignes
DELVAUX, Valérie ULg; DIOH, Alioune ULg; Schoenen, Jean ULg

in Ahead in neurology (1999), 3(1), 10-15

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See detailMorphologie, distribution et écologie comparées d'Amblystegium tenax et d'A. fluviatile en Belgique
Vanderpoorten, Alain ULg; Empain, Alain ULg

in Belgian Journal of Botany (1999), 132(1), 3-12

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See detailLa guerre du tabac : Francorchamps contre-attaque
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailDu logement ouvrier au logement social
Frankignoulle, Pierre ULg

in Cahiers de l'Urbanisme (Les) (1999), 25-26

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See detailReview of bone formation stimulants
Reginster, Jean-Yves ULg

in Osterologia-Osteology (1999), 2

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See detailBulletin bibliographique de la Société Rencesvals, 1998-1999
Horrent, Jacques ULg; Henrard, Nadine ULg

in Bulletin bibliographique de la Société Rencesvals (1999), (30), 167

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See detailLicéité des baux au regard de la police de l'aménagement du territoire et de l'urbanisme
Delnoy, Michel ULg

in Actualités Juridiques des Baux (1999)

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See detailIntérêt de la tomographie à émission de positons dans l'évaluation des tumeurs gastro-intestinales
Rigo, Pierre ULg; Albérini, Jean-Louis; Hustinx, Roland ULg et al

in Acta Endoscopica (1999), 29(2), 129-138

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des ... [more ▼]

La TEP au 18FDG présente de nombreuses indications dans l'évaluation des tumeurs digestives. Son rôle principal concerne le bilan d'extension des récidives tumorales démontrées ou suspectées mais des indications plus ponctuelles concernent évalement le diagnostic différentiel des masses pancréatiques et le bilan du cancer de l'oesophage. Le principal avantage de la TEP résulte de la nature métabolique du signal indépendant et complémentaire des modifications anatomiques visibles en imagerie classique. Un autre avantage est lié à l'examen du corps entier aujourd'hui pratiqué systématiquement. La TEP trouve dès lors sa place en première ligne dans ses différentes indications. [less ▲]

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