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See detailCompte rendu de l'ouvrage de D. Giovannangeli : Le retard de la conscience
Cormann, Grégory ULg

in Revue Internationale de Philosophie (2002), 219(1), 144-149

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See detailNormative and psychometric data from the Body Image Assessment - Revised in a population of french-speaking women
Bragard, Isabelle ULg; Mayers, I.; Demoulin, Catherine et al

in Psychologica Belgica (2002), 42(4), 227-249

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female ... [more ▼]

This article concerns the creation of norms and the validation in French of the Body Image Assessment – Revised (BIA-R; Beebe, Holmbeck, & Grzeskiewicz, 1999). The sample comprised 100 normal female subjects. They completed questionnaires assessing body experience, eating pathology, psychological functioning, general perception and the BIA-R (Beebe et al., 1999). This test consists of nine silhouettes from which the subject has to choose the somatotype corresponding to her actual shape (cognitive response), the way she feels (affective response) and the way she would like to look (optative response). The results show a good concurrent validity for the cognitive and affective indices and the affective/ cognitive vs. optative divergences. On the other hand, we were not able to demonstrate such validity for the optative index and the affective vs. cognitive divergence index [less ▲]

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See detailThree years experiment with the same tin oxide sensor arrays for the identification of malodorous sources in the environment
Romain, Anne-Claude ULg; Nicolas, Jacques ULg; Andre, Philippe ULg

in Sensors and actuators. B, Chemical (2002), (84), 271-277

The paper discusses the ability of recognition models to classify malodours in the environment 3 years after their calibration, with the same sources releasing odours. Two methodologies applicable either ... [more ▼]

The paper discusses the ability of recognition models to classify malodours in the environment 3 years after their calibration, with the same sources releasing odours. Two methodologies applicable either in the lab or in the field are used. The effect of the long term drift of the sensors is highlighted on the results of principal component analysis (PCA) and of discriminant function analysis (DFA). The paper examines also the applicability of some drift counteraction methods proposed in the literature. Handled with some care, a correction based on the drift direction in the principal components subspace should be applicable to the classification of real odorous sources in the field. [less ▲]

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See detailRecent developments in infectious bovine rhinotracheitis
Thiry, Etienne ULg; Lemaire, Mylène; Keuser, Véronique et al

in Cattle Practice (2002), 10

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See detailLymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy.
Pierard, Claudine ULg; Goffin, Véronique ULg; Arrese Estrada, Jorge ULg et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15(2), 112-9

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and ... [more ▼]

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. METHOD: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. RESULTS: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. CONCLUSION: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg. [less ▲]

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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See detailAngot salue Guibert
Demoulin, Laurent ULg

in Critique : Revue Générale des Publications Françaises et Etrangères (2002), 663-664

Le roman L'Inceste de Christine Angot s'ouvre presque sur les mêmes phrases que le roman A l'ami qui ne m'a pas sauvé la vie d'Hervé Guibert. Quelle est la valeur de ce détournement textuel et quel rôle ... [more ▼]

Le roman L'Inceste de Christine Angot s'ouvre presque sur les mêmes phrases que le roman A l'ami qui ne m'a pas sauvé la vie d'Hervé Guibert. Quelle est la valeur de ce détournement textuel et quel rôle joue-t-il dans le roman d'Angot? [less ▲]

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See detailLa guerre et la médecine d'une culture de paix. 5. Synopsis des armes non létales.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(3), 176-8

Non lethal weapons may be harmful for people. The effects are accidental in some instances. For some weapons, they are clearly intentional. The eventuality of a fatal issue cannot be ruled out.

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See detailUntersuchung von Spaltungs- und Koaleszenzvorgängen in einer Messzelle mit pulsierten Füllkörpern
Klinger, S; Henschke, M; Pfennig, Andreas ULg

in Chemie Ingenieur Technik (2002), 74(3), 256-261

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See detailAdvantages and disadvantages of a control programme against infectious bovine rhinotracheitis in Belgium
Limbourg, B.; Kerkhofs, P.; Massard, C. et al

in Annales de Médecine Vétérinaire (2002), 146(2, APR-MAY), 57-69

A working party of the "Association d'Epidemiologie et de Sante Animale" assessed the strategy for a control of infectious bovine rhinotracheitis (IBR) in Belgium and studied its feasability and the ... [more ▼]

A working party of the "Association d'Epidemiologie et de Sante Animale" assessed the strategy for a control of infectious bovine rhinotracheitis (IBR) in Belgium and studied its feasability and the different programmes to be applied. Epidemiology of IBR in Belgium, vaccination, diagnostic methods, economic aspects of IBR control, Belgian laws regarding IBR and the motivation of people in the field were described. The advantages and disadvantages of three programmes were analysed: to maintain the current situation, to protect cattle against clinical disease and to control and eradicate IBR. [less ▲]

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See detailShunt cardiaque droite-gauche : étiologie possible de migraine avec aura ?
Schoenen, Jean ULg

in Migraine Contact (2002), 2

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See detailNSAIDS : not just COX-2 inhibitors ?
Henrotin, Yves ULg

in Intern Clin Pract Series (2002), 19

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See detailModellierung von Faserbett-Koaleszenzabscheidern
Speth, H; Pfennig, Andreas ULg; Chatterjee, M et al

in Chemie Ingenieur Technik (2002), 74(3), 266-270

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See detailLa dignité humaine comme concept juridique
Fierens, Jacques ULg

in Journal des Tribunaux (2002)

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See detailEtude longitudinale de l'hémodynamique artérielle mésentérique chez le nouveau-né prématuré stable en alimentation entérale
Battisti, Oreste ULg; Withofs, L.; Adant-François, A. et al

in Louvain Medical (2002), 121

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See detailBPDZ 154 Activates Adenosine 5’-Triphosphate-Sensitive Potassium Channels; In Vitro Studies Using Rodent Insulin-Secreting Cells and Islets Isolated from Patients with Hyperinsulinism
Cosgrove, K. E.; Antoine, M.-H.; Lee, A. T. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87

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See detailMicro-organismes pathogènes et viande : la traçabilité alliée de la sécurité.
Daube, Georges ULg

in Extrait du Bulletin de la Société Royale des Sciences de Liège (2002), 1

Meat microbial contamination is frequent in relation to the multiple sources of contamination farm the farm to the fork. These potential hazards must be considered in term of real risk for the consumer ... [more ▼]

Meat microbial contamination is frequent in relation to the multiple sources of contamination farm the farm to the fork. These potential hazards must be considered in term of real risk for the consumer. Thus, each microbiological hazard must be c1assified by scientists by on going probability and by disease gravity. Belgium has developed a high quality surveillance system for the zoonotic agents along the meat production chain. Today, the authorities must make the adequate choices for prevention and communication about these risks. [less ▲]

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See detailLatest discoveries in prostaglandin receptor modulators
Benoit, P.; De Leval, X.; Pirotte, Bernard ULg et al

in Expert Opinion on Therapeutic Patents (2002), 12

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See detailBulletin bibliographique de la Société Rencesvals, 2001-2002
Henrard, Nadine ULg

in Bulletin bibliographique de la Société Rencesvals (2002), (33), 1-179

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See detailAdvances in the field of COX-2 inhibition
De Leval, X.; Julémont, F.; Delarge, J. et al

in Expert Opinion on Therapeutic Patents (2002), 12

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See detailEvolution des donnees maternelles et perinatales recueillies en routine entre 1980 et 1998 a la maternite de reference de Rutshuru en Republique democratique du congo. Deces maternels et interventions obstetricales.
Mugisho, Etienne; Dramaix, Michele; Porignon, Denis ULg et al

in Sante (Montrouge, France) (2002), 12(2), 247-51

This report is the first of 2 papers that analyse data routinely collected in the maternity ward of Rutshuru (democratic Republic of Congo). The present work describes the evolution of caesarean section ... [more ▼]

This report is the first of 2 papers that analyse data routinely collected in the maternity ward of Rutshuru (democratic Republic of Congo). The present work describes the evolution of caesarean section, maternal deaths and the associated risk factors. MATERIAL AND METHODOLOGY: Between 1980 and 1998, data on 13,042 deliveries were collected. Characteristics, mortality, morbidity of mothers and new-borns and obstetrical interventions were recorded. The statistical analyses applied included khi2, t-test, simple linear and multiple logistic regression. RESULTS: Fifteen percent had a caesarean section and 1.9% of women died. When referred to the expected births during the period, these numbers led to a ratio of 150 maternal deaths for 100,000 expected births and a ratio of caesarean section of 1.2%. At admission, 35% of the women presented at least one of the four risk factors used for reference. The proportion of women with at least one of the 4 risk factors went up from 26.1% to 39.5%. The proportion of caesarean sections went up from 1.9% to 34.1%. The proportion of maternal deaths remained constant except in 1988, 1994, 1995 and 1997. Three of the four reference factors, the Baudeloque diameter, parity and height were associated with caesarean section. Age only was associated with maternal death. Education and marital status were both associated with caesarean section and maternal death. CONCLUSION: This analysis shows high levels of maternal mortality and caesarean section. The authors recommend to analyse on a larger scale the value of the reference factors used in antenatal services and to standardise indications for the different obstetrical interventions. [less ▲]

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See detailN-(3-Phenoxy-4-pyridinio)methanesulfonamidate
Michaux, C.; Charlier, C.; Julémont, F. et al

in Acta Crystallographica (2002)

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See detailLe médecin du travail face au harcèlement moral au travail : constats et prespectives
Gruslin, Isabelle ULg; Italiano, Patrick ULg; Faulx, Daniel ULg

in Médecine du Travail & Ergonomie= Arbeidsgezondheidszorg & Ergonomie (2002), 39(2), 61-68

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du ... [more ▼]

L'article de D. Faulx et C. Geuzaine, paru dans le numéro 3-2000 de cette revue, aborde l'étendue du phénomène du harcèlement moral ainsi que les aspects juridiques de la définition, la description du processus, ses conséquences médicales et les facteurs de risque. Dans la suite de cette étude, nous présentons ici les résultats d'une enquête menée auprès des médecins du travail, en tant que témoins et intervenants privilégiés dans le domaine du harcèlement. Cette enquête vise à apporter des informations descriptives originales concernant les attitudes, les opinions et représentations des médecins du travail par rapport au phénomène de harcèlement moral. En outre, elle est l'occasion de tester une série d'hypothèses sur les facteurs pouvant influencer l'attitude des médecins du travail vis-à-vis du harcèlement moral. [less ▲]

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See detailLe medicament du mois. La rosiglitazone (Avandia).
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(4), 236-9

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma ... [more ▼]

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma) and improve insulin sensitivity. In Belgium as in all European countries, rosiglitazone is indicated for the treatment of type 2 diabetes, only in combination with another antidiabetic oral agent, in patients insufficiently controlled with metformin or a sulphonylurea at a maximal tolerated dose. In these patients, rosiglitazone, at a daily dose of 4 mg (sometimes 8 mg/day with metformin), reduces fasting glycaemia by 2-3 mmol/l and glycated haemoglobin level by about 1%. It exerts also favourable effects on some risk factors related to insulin resistance syndrome, which may contribute to improve cardiovascular prognosis of patients with type 2 diabetes. Hepatic safety of rosiglitazone seems to be good, although it is still recommended to check liver enzymes regularly. As all glitazones, rosiglitazone moderately promotes weight gain. It can also induce some fluid retention which may reveal or aggravate heart failure in at risk patients. [less ▲]

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See detailUnusual traits of the pyoverdin-mediated iron acquisition system in Pseudomonas putida strain BTP1.
Ongena, MARC ULg; Jacques, Philippe ULg; Delfosse, Philippe et al

in Biometals (2002), 15(1), 1-13

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin ... [more ▼]

Fluorescent Pseudomonas species are characterized by the production of pyoverdin-type siderophores for Fe3+ acquisition in iron-limited environments. Since it produces a structurally specific pyoverdin, Pseudomonas putida strain BTP1 could represent a valuable tool in an attempt to correlate the structural features of these compounds with some specificity in their two main properties i.e. affinity for iron and recognition rate by other Pseudomonas strains. An uncommonly high affinity for iron of the pyoverdin synthetized by P. putida BTP1 was observed by comparing both the apparent stability constant and the decomplexation kinetic of its ferric complex with those of ferripyoverdins from other strains. On another hand, results from growth stimulation experiments and labeled ferripyoverdin uptake assays highlighted the very low recognition rate of BTP1 isopyoverdins by membrane receptors of foreign strains. By contrast, P. putida BTP1 was able to utilize a broad spectrum of structurally unrelated exogenous pyoverdins by means of multiple receptors that are likely constitutively expressed in its outer membrane. The unusual traits of its pyoverdin-mediated iron acquisition system should contribute to enlarge the ecological competence of Pseudomonas putida BTP1 in terms of colonization and persistence in the rhizosphere. [less ▲]

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See detailComment gérer la police dans une période de changement?
Schoenaers, Frédéric ULg

in Revue Française de Gestion (2002), 3-4(139),

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See detailSyndrome cérébelleux paradoxal provoqué par un méningiome chez une vache
Danlois, F.; Poncelet, Luc; Rollin, Frédéric ULg

in Annales de Médecine Vétérinaire (2002), 146

A paradoxical vestibular syndrome caused by a fibroblastic meningioma is described in a 20 month-old Holstein heifer. Clinical signs included head tilt, jerking movements of the head and neck, circling to ... [more ▼]

A paradoxical vestibular syndrome caused by a fibroblastic meningioma is described in a 20 month-old Holstein heifer. Clinical signs included head tilt, jerking movements of the head and neck, circling to the left, and also abducted and hypermetric right limbs. The animal was culled and the forebrain therefore was unavailable for histopathological study. The tumour was found on the right side, adherent to the dura mater at the level of the pontomedullary junction. The paradoxical vestibular signs were explained by the presence of the mass causing a loss of cerebellar inhibition over homolateral vestibular nuclei resulting in hyperactivity on the same side as the tumour and simulating a contralateral functional loss. The jerking head and neck movements might be caused by the same lesion although a concurrent forebrain lesion could not be excluded. [less ▲]

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See detailRadiative transfer based scaling of LAI/FPAR retrievals from reflectance data of different resolutions.
Tian, Y; Wang, Y; Zhang, Y et al

in Remote Sensing of Environment (2002), 84(1), 143-159

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See detailSynthesis of peptide-modified pyoverdins by a fluorescent Pseudomonas strain grown in isoleucine-supplemented medium
Ongena, MARC ULg; Jacques, Philippe ULg; De Pauw, Edwin ULg et al

in Letters in Peptide Science (2002), 8(1), 21-27

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass ... [more ▼]

The pattern of pyoverdin-type siderophores produced by Pseudomonas putida BTP16 in iron-limited succinate medium supplemented or not with isoleucine was characterized by electrospray ionization mass spectrometry. Two new compounds were observed in culture supernatants from BTP16 grown in the presence of isoleucine. For both molecules, mass differences with pyoverdins originally synthesized by the strain were only interpreted considering the incorporation of Ile into the peptide chain. Further evidence supporting this phenomenon was provided by radioactivity incorporation in pyoverdins produced in the presence of C-14-labeled Ile. Our results are discussed in relation to the non-ribosomal mechanism supposed to be involved in the synthesis of these molecules. [less ▲]

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See detailIncreased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells.
Giet, Olivier ULg; Van Bockstaele, Dirk R; Di Stefano, Ivano et al

in Blood (2002), 99(6), 2023-31

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood ... [more ▼]

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood CD34+ cells. Migration toward medium conditioned by the stromal-derived factor-1-producing cell line MS-5 was studied in bovine serum albumin- and fibronectin (Fn)-coated transwells. Migration was reduced in cycling CD34+ cells and long-term culture-initiating cells (LTC-ICs) compared with their noncycling counterparts across Fn but not across bovine serum albumin. Conversely, Fn binding was higher in cycling CD34+ cells and LTC-ICs compared with noncycling progenitor cells, while adhesion of both subsets to bovine serum albumin was undetectable. The contribution of alpha4 and alpha5 integrins in mediating adhesion and migration of activated CD34+ cells onto Fn was analyzed by neutralization experiments. While alpha4-mediated Fn binding decreased during G(2)/M, alpha5 integrin-mediated adhesion increased during transit from G(0)/G(1) to S and G(2)/M phases. As for migration, the contribution of alpha4 integrin was similar in all phases, whereas alpha5-directed migration was lower in G(2)/M compared with G(0)/G(1) and S phases. Defective migration of cycling CD34+ cells was not due to differences in alpha5 integrin expression. In conclusion, chemotaxis across Fn is less efficient in cycling progenitor cells in correlation with an increased Fn binding capacity. In addition, alpha4 and alpha5 integrin functions are independently modulated during cell cycle transit. [less ▲]

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See detailAnalysis of variables related to intrinsic motivation in a boys’ physical education class
Cloes, Marc ULg; Motter, Pascale; Ledent, Maryse ULg et al

in AVANTE (2002), 8(1), 1-14

In physical education settings, the development of intrinsic motivation in students is a central concern for every teacher. However, most studies have focused on isolated variables using quantitative ... [more ▼]

In physical education settings, the development of intrinsic motivation in students is a central concern for every teacher. However, most studies have focused on isolated variables using quantitative approaches. The purpose of this study was to underline the existence of relationships between students’ intrinsic motivation (assessed by dispositional factors) and individual/collective situational factors. A secondary school boys’ class and its teacher were the subjects of the study. Questionnaires and interviews were used. Data were initially processed from the class point of view. Based on a cluster analysis determined by intrinsic motivation level, two groups of students were compared. Qualitative analysis was based on the answers of the two most and the two least motivated students of the class. Extracurricular practice (individual situational variable), teacher-students’ interaction and mastery climate (collective situational variables) were identified among the factors related to students’ intrinsic motivation. Inter-individual diversity of influencing variables was pointed out. [less ▲]

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See detailCaractéristiques du système immunitaire du fœtus bovin et du veau nouveau-né. Implications dans la prévention et le diagnostic des infections d’origine virale
Thiry, Etienne ULg; Schynts, F.; Lemaire, Mylène

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 225-232

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three ... [more ▼]

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three examples are illustrated in this review : direct and indirect consequences of the infection of the fetus by the bovine viral diarrhea virus; guidelines for a prevention and diagnosis of this viral infection are given; the infection of the neonate by rotaviruses where colostral immunity has a key role in the prevention of the disease; the infection of the neonate by bovine herpesvirus 1 in the presence of colostral immunity which does not prevent latency and can lead to seronegative latent carriers after the disappearance of maternal antibodies. [less ▲]

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See detailEtalonnage de la figure complexe de Rey sur une population d’enfants de six à douze ans
Garcet, Serge ULg; Deltour, Jean-Jacques; Remacle, Michel

in Revue Scientifique de l'AIGS (2002), 1

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See detailRole of acetaldehyde in the discriminative stimulus effects of ethanol
Quertemont, Etienne ULg; Grant, Kathleen A

in Alcoholism, Clinical & Experimental Research (2002), 26(6), 812-817

Background: Acetaldehyde has been suggested to mediate some of the effects of ethanol. Acetaldehyde can be produced by the enzyme catalase within the brain after ethanol administration. The catalase ... [more ▼]

Background: Acetaldehyde has been suggested to mediate some of the effects of ethanol. Acetaldehyde can be produced by the enzyme catalase within the brain after ethanol administration. The catalase inhibitor 3-amino-1,2,4-triazole (AT) reduces the production of acetaldehyde, and AT administration can reduce a number of ethanol-induced behavioral effects; this suggests the involvement of acetaldehyde in these behaviors. However, a role for acetaldehyde in mediating the discriminative stimulus effects of ethanol remains unclear. Methods: The contribution of acetaldehyde to the discriminative stimulus effects of ethanol was investigated by use of a two-lever drug discrimination paradigm with food reinforcement. Male Long-Evans rats were trained to discriminate water from either 1.0 or 2.0 g/kg ethanol. Stimulus substitution tests were conducted with ethanol (0 –2.5 g/kg by gavage) and acetaldehyde (0–300 mg/kg intraperitoneally). A cumulative dose-response procedure was then used to investigate the effects of pretreatments with AT (0.5 and 1.0 g/kg intraperitoneally) on ethanol discrimination. Results: Acetaldehyde up to doses that decreased response rates (300 mg/kg) did not substitute for the discriminative stimulus effects of 1.0 or 2.0 g/kg ethanol. In addition, AT pretreatment did not affect the dose-response curves for ethanol discrimination. Conclusions: These results show that exogenous acetaldehyde administration does not produce discriminative stimulus effects that are similar to those of ethanol. Also, pretreatment with the catalase inhibitor did not affect the dose-response curve for ethanol discrimination, and this suggests that endogenously produced acetaldehyde does not contribute to the discriminative stimulus effects of ethanol. Together these results suggest that acetaldehyde does not mediate the discriminative stimulus effects of 1.0 to 2.0 g/kg ethanol. [less ▲]

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See detailUnified stress update algorithms for the numerical simulation of large deformation elasto-plastic and elasto-viscoplastic processes
Ponthot, Jean-Philippe ULg

in International Journal of Plasticity (2002), 18(1), 91-126

This paper is concerned with unified stress update algorithms for elastoplastic and elasto-viscoplastic constitutive equations for metals submitted to large deformations. We present here a newly developed ... [more ▼]

This paper is concerned with unified stress update algorithms for elastoplastic and elasto-viscoplastic constitutive equations for metals submitted to large deformations. We present here a newly developed time integration algorithm which is, in the case of J2 flow theory material behavior, an extension to the viscoplastic range of the classical radial return algorithm for plasticity. The resulting unified implicit algorithm is both efficient and very inexpensive. Moreover, if there is no viscosity effect (rate-independent material) the presented algorithm degenerates exactly into the classical radial return algorithm for plasticity. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailFurther evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study
Hansenne, Michel ULg; Pinto, Emmanuel ULg; Pitchot, William ULg et al

in Personality & Individual Differences (2002), 33(6), 967-977

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively ... [more ▼]

In the biosocial model of Cloninger, three major personality dimensions, novelty seeking (NS), harm avoidance (HA), and reward dependence (RD) are dependent on central monoaminergic systems, respectively dopaminergic, serotonergic, and noradrenergic. This study investigated the relationships between these major personality dimensions and growth hormone (GH) responses to both apomorphine and clonidine challenge tests in healthy subjects. GH responses to apomorphine were significantly correlated with NS when peak relative values were considered (r=0.47, P=0.03). HA and RD did not show any relationships with the endocrine responses. In contrast, no significant relationship existed between GH responses to clonidine and any of the three temperament dimensions. These results gave another support of the hypothesized link between NS and dopaminergic central neurotransmission. In contrast, the results did not confirm the association between RD and noradrenergic central neurotransmission, probably because RD is poorly validated. This partial confirmation might suggest that the link between personality traits and neurotransmission systems is probably indirect. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPetite réflexion sur la qualité du bois d'épicéa
Hebert, Jacques ULg; Herman, Marc; Jourez, Benoît ULg

in Forêt Wallonne (2002), (60), 24-25

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte ... [more ▼]

En termes de qualité du bois, l'influence du sylviculteur est déterminante. En effet, dès la décision de plantation, et ensuite, par le jeu des soins culturaux et des éclaircies, il va façonner, compte tenu des conditions environnementales, les caractéristiques de la matière première qui en définiront les aptitudes technologiques. [less ▲]

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See detailContrôle de l'hypertension artérielle: peut-on faire mieux?
Krzesinski, Jean-Marie ULg

in Journal de Cardiologie = Tijdschrift voor Cardiologie (2002), 14(5), 180-181

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See detailLe traitement de la phraséologie dans DEFI
Michiels, Archibal ULg

in Linguistica Antverpiensia (2002)

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See detailMagnetic and transport measurements on melt-textured DyBCO single domains
Vanderbemden, Philippe ULg; Misson, Vincent; Ausloos, Marcel ULg et al

in Physica C: Superconductivity (2002), 372(Part 2), 1225-1228

In this communication we report critical current measurements of melt processed DyBa2Cu3O7-x samples determined by several measuring techniques. First the material was characterized by AC susceptibility ... [more ▼]

In this communication we report critical current measurements of melt processed DyBa2Cu3O7-x samples determined by several measuring techniques. First the material was characterized by AC susceptibility and DC magnetization. The results are characteristic of good quality melt-processed (RE)BCO material with T-c = 89 K and Jc(77 K, 1 T) = 10^4 A/cm^2. Next, pulsed currents were used in order to determine both I-V curves and transport critical currents. The origin of the discrepancy between transport and magnetic data has been discussed. The results point out significant local variations of the critical current density throughout the single domain. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailStructural approach of the mechanism of inhibition of -chymotrypsin by coumarins
Wouters, J.; Huygens, M.; Pochet, L. et al

in Bioorganic & Medicinal Chemistry Letters (2002), 12

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See detailPhylogeny of the genus Apodemus with a special emphasis on the subgenus Sylvaemus using the nuclear IRBP gene and two mitochondrial markers: cytochrome b and 12S rRNA.
Michaux, Johan ULg; Chevret, P.; Filippucci, M*-G et al

in Molecular Phylogenetics & Evolution (2002), 23(2), 123-36

Phylogenetic relationships among 17 extant species of Murinae, with special reference to the genus Apodemus, were investigated using sequence data from the nuclear protein-coding gene IRBP (15 species ... [more ▼]

Phylogenetic relationships among 17 extant species of Murinae, with special reference to the genus Apodemus, were investigated using sequence data from the nuclear protein-coding gene IRBP (15 species) and the two mitochondrial genes cytochrome b and 12S rRNA (17 species). The analysis of the three genes does not resolve the relationships between Mus, Apodemus, and Rattus but separates Micromys from these three genera. The analysis of the two mitochondrial regions supported an association between Apodemus and Tokudaia and indicated that these two genera are more closely related to Mus than to Rattus or Micromys. Within Apodemus, the mitochondrial data sets indicated that 8 of the 9 species analyzed can be sorted into two main groups: an Apodemus group, with A. agrarius, semotus, and peninsulae, and a Sylvaemus group, with uralensis, flavicollis, alpicola, sylvaticus, and hermonensis. The position of Apodemus mystacinus is ambiguous and might be either included in Sylvaemus or considered a distinct subgenus, Karstomys, more closely related to Sylvaemus than to Apodemus. Estimation of the divergence time for these taxa suggests a separation between 7 and 8 My ago for the three groups (mystacinus and the two subgenera Apodemus and Sylvaemus). Within each subgenus, divergence times are between 5.4 and 6 My for Apodemus and between 2.2 and 3.5 My for Sylvaemus and mystacinus. [less ▲]

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See detailRisk factors for hepatitis C: past, present and future
Delwaide, Jean ULg; Bourgeois, N.; Colle, I. et al

in Acta Gastro-Enterologica Belgica (2002), 65(2), 87-89

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to ... [more ▼]

Patients at risk for hepatitis C (HCV) are those exposed to a major risk factor (i.e. blood transfusion prior 1990, and intravenous drug abuse), and those exposed to a minor risk factor (sexual, mother-to-infant transmission, household contact, nosocomial contamination). The present paper aims to review the current and past modes of transmission of the virus C. [less ▲]

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See detailLe contrat de rivière au service de la politique européenne de l'eau.
Rosillon, Françis ULg; Vander Borght, Paul ULg

in Wallonie (2002), (72), 88-97

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See detailLe mélange épicéa-douglas, une association intéressante pour le sylviculteur ? 1ère partie
Colson, Vincent ULg; Claessens, Hugues ULg; Pauwels, D. et al

in Silva Belgica (2002), 109(3), 34-38

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See detailThe value of serologic markers in indeterminate colitis: A prospective follow-up study
Joossens, S.; Van Steen, Kristel ULg; Vermeire, S. V. et al

in Gastroenterology (2002), 122(5), 1242-1247

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See detailL'iconographie du meurtre de saint Lambert de Liège
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (2002)

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See detailElectronic structure of thallium filled skutterudites studied by x-ray absorption and Mossbauer spectroscopy
Long, G. J.; Mahieu, B.; Sales, B. C. et al

in Journal of Applied Physics (2002), 92(12), 7236-7241

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4 ... [more ▼]

Thallium L-III-edge x-ray absorption and iron-57 and tin-119 Mossbauer spectral measurements have been carried out to probe the electronic structure of the three sites in the filled skutterudite TlxCo4-yFeySb12 and TlxCo4Sb12-zSnz compounds with a range of x, y, and z values. The thallium L-III-edge x-ray absorption spectra are independent of x, y, and z and are well reproduced by full multiple scattering calculations with a cluster with a radius of 8.5 Angstrom centered on thallium. The iron-57 Mossbauer spectra consist of two doublets and the major component is assigned to iron on the cobalt sublattice in view of its hyperfine parameters. The origin of the minor component is uncertain and is tentatively assigned to either iron with thallium vacancies as next nearest neighbors or to iron in the voids. The tin-119 Mossbauer spectral hyperfine parameters clearly indicate that tin substitutes for antimony in the skutterudite structure. Further, the tin electronic configuration is very similar to that of antimony and is insensitive to the thallium content. (C) 2002 American Institute of Physics. [less ▲]

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See detailIntranasal infusion of enilconazole for treatment of sinonasal aspergillosis in dogs.
Zonderland, Jean-Luc; Stork, Christoph; Saunders, Jimmy et al

in Journal of the American Veterinary Medical Association [=JAVMA] (2002), 221

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See detailCompte rendu de l’ouvrage de Gianluca Mori : Bayle philosophe
Donneau, Olivier ULg

in Hieros : Bulletin Annuel de la Société Belgo-luxembourgeoise d'Histoire des Religions (2002), 6

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See detailCompte rendu de ARDON, Vie de Benoît d'Aniane, Abbaye de Bellefontaine, 2001
George, Philippe ULg

in Moyen Age (Le) (2002)

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See detailSubcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins
Lefebvre, Laurent; Ciminale, Vincenzo; Vanderplasschen, Alain ULg et al

in Journal of Virology (2002), 76(15), 7843-7854

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for ... [more ▼]

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for at least four proteins: Tax and Rex, which are involved in transcriptional and posttranscriptional regulation, respectively, and the accessory proteins R3 and G4 (for BLV) and p12(I), p13(II), and p30(II) (for HTLV-1). The present study was aimed at characterizing the subcellular localization of BLV R3 and G4. The results of immunofluorescence experiments on transfected HeLa Tat cells demonstrated that R3 is located in the nucleus and in cellular membranes, as previously reported for HTLV-1 p12(1). In contrast, G4, like p13(II), is localized both in the nucleus and in mitochondria. In addition, we have shown that G4 harbors a mitochondrial targeting signal consisting of a hydrophobic region and an amphipathic alpha-helix. Thus, despite a lack of significant primary sequence homology, R3 and p12(1) and G4 and p13(II) exhibit similar targeting properties, suggesting possible overlap in their functional properties. [less ▲]

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See detailFirst synthesis of a '1,2-diquinone-calix[4]arene'. Interaction of its reduced form with Ag+
Vataj, Rame; Ridaoui, Hassan; Louati, Alain et al

in Journal of Electroanalytical Chemistry (2002), 519(1-2), 123129

Electrochemical oxidation of 5,11,17,23-tetra-tert-butyl-25,26-bis(diphenylphosphinoylmethoxy)-27,28-dihydroxycalix[4]arene (3), a calixarene with two phosphoryl units appended on proximal positions ... [more ▼]

Electrochemical oxidation of 5,11,17,23-tetra-tert-butyl-25,26-bis(diphenylphosphinoylmethoxy)-27,28-dihydroxycalix[4]arene (3), a calixarene with two phosphoryl units appended on proximal positions, affords the corresponding '1,2-diquinonecalix[4]arene' (4). The formation of 4 results from nucleophilic attack of residual water on anodically generated diphenoxylium. cations. Preliminary voltammetric experiments in CH3CN on a platinum electrode showed that 4 is suitable for electrochemical detection of the silver metal cation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailRhoA inhibition is a key step in pituicyte stellation induced by A(1)-type adenosine receptor activation.
Rosso, Lia; Peteri-Brunback, Brigitta; Vouret-Craviari, Valerie et al

in Glia (2002), 38(4), 351-62

Pituicyte stellation in vitro represents a useful model with which to study morphological changes that occur in vivo in these cells during times of high neurohypophysial hormone output. This model has ... [more ▼]

Pituicyte stellation in vitro represents a useful model with which to study morphological changes that occur in vivo in these cells during times of high neurohypophysial hormone output. This model has helped us establish the hypothesis of a purinergic regulation of pituicyte morphological plasticity. We first show that ATP induces stellation in 37% of pituicytes, an effect that is secondary to the metabolism of ATP to adenosine. Adenosine-induced stellation of pituicytes appears to be mediated by A(1)-type receptors. The effect is independent of intracellular calcium and does not involve the mitogen-activated protein kinase pathway. The basal (nonstellate) state of pituicytes depends on tonic activation of a Rho GTPase because both C3 transferase (a Rho inhibitor) and Y-27632 (an inhibitor of p160Rho kinase) can induce stellation. Lysophosphatidic acid, a Rho activator, blocks the morphogenic effect of adenosine dose-dependently. Using a specific RhoA pull-down assay, we also show that downregulation of activated RhoA is the key event coupling A(1) receptor activation to pituicyte stellation, via F-actin depolymerization and microtubule reorganization. Finally, both vasopressin and oxytocin can prevent or reverse adenosine-induced stellation. The effects of vasopressin, and those of high concentrations of oxytocin, are mediated through V(1a) receptors. Placed within the context of the relevant literature, our data suggest the possibility of a purinergic regulation of pituicyte morphological plasticity and subsequent modulation of hormone release, with these hormones providing a negative feedback mechanism. [less ▲]

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See detailVolumineuse masse pelvienne chez un homme jeune
Andrianne, Robert ULg; Detroz, Bernard ULg; Delbecque, Katty ULg et al

in Revue Médicale de Liège (2002), 57(3), 148-154

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See detailResults of a whole genome scan targeting QTL for growth and carcass traits in a Pietrain x Large White intercross
Nezer, C.; Moreau, L.; Wagenaar, D. et al

in Genetics, Selection, Evolution (2002), 34(3, May-Jun), 371-387

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We ... [more ▼]

We herein report the results of a whole genome scan performed in a Pietrain x Large White intercross counting 525 offspring to map QTL influencing economically important growth and carcass traits. We report experiment-wide significant lod scores (> 4.6) for meatiness and fat deposition on chromosome SSC2, and for average daily gain and carcass length on chromosome SSC7. Additional suggestive lod scores (> 3.3) for fat deposition are reported on chromosomes SSC1, SSC7 and SSC13. A significant dominance deviation was found for the QTL on SSC1, while the hypothesis of an additive QTL could not be rejected for the QTL on SSC7 and SSC13. No evidence for imprinted QTL could be found for QTL other than the one previously reported on SSC2. [less ▲]

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See detailEffect of instillation into lung of autologous blood on pulmonary function and tracheobronchial wash cytology
Art, Tatiana ULg; Tack, S.; Kirschvink, Nathalie et al

in Equine Veterinary Journal. Supplement (2002), 34

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced ... [more ▼]

This study aimed at measuring the functional consequences and the pulmonary cytology changes following a simulation of pulmonary haemorrhage. Pulmonary function tests including lobeline-induced hyperventilation, cytology of tracheo-bronchial wash (TBW) and thoracic radiographs were performed before, as well as 1, 7, 14 and 28 days after, the instillation of 300 ml of blood into the lungs of 4 horses deemed free of exercise-induced pulmonary haemorrhage (Group 1). Control data (Group 2) were obtained by instilling the same volume of saline into the lungs of the same horses in a crossover design (control). The instillation of blood or saline resulted in an increase in the number of neutrophils in the TBW. Thoracic radiographs showed increased opacity in the caudodorsal region of the lungs in 4/4 (Day 1) and 2/4 horses (Day 7), in Group 1, and in 2/4 (Day 1) and 0/4 horses (Day 7) in the control group. These changes were attributed to the instillation procedure rather than the nature of the instilled material. Breathing mechanics and arterial blood gases at rest were not affected in either Groups 1 or 2. However, the maximal expiratory peak flow recorded during lobeline-induced hyperventilation was significantly lower (P<0.05) and the total pulmonary resistance significantly higher (P<0.05) on Day 1 in Group 1, but not Group 2. These observations suggest that expiratory flows might be partly limited in bleeders when breathing at high airflow [less ▲]

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See detailSerotonin, personality and borderline personality disorder
Hansenne, Michel ULg; Pitchot, William ULg; Ansseau, Marc ULg

in Acta Neuropsychiatrica (2002), 14(2), 66-70

Serotonin is one of the neurotransmitters implicated in normal personality Many psychobiological models of personality include,some dimensions related to serotonin. For instance, the harm avoidance ... [more ▼]

Serotonin is one of the neurotransmitters implicated in normal personality Many psychobiological models of personality include,some dimensions related to serotonin. For instance, the harm avoidance dimension of the blosocial model developed by Cloninger is related to serotonergic activity Higher scores on the harm avoidance dimension should theoretically reflect increased serotonergic activity However, correlation studies related serotonin activity to harm avoidance dimension have not yielded consistent findings. These controversial results are probably related to the complexity of the neurotransmitter systems, and the different assessment techniques used in these studies. Finally, recent genetic studies have examined the association between personality dimensions and serotonergic receptor polymorphisms with mixed results. Serotonin is not only related to some dimensions of normal personality Several psychopathological disorders are associated with serotonergic dysfunction. More particularly, borderline personality disorder (BPD) can be defined by many of the symptoms associated with serotonergic dysregulation, including affective lability, suicidal behaviours, impulsivity and loss of impulse control. Indeed, several reports have demonstrated the efficacy of selective serotonin re-uptake drugs in treating the depressive and impulsive symptoms of patients with BPD. Moreover, some challenge studies have reported a lower serotonergic activity in BPD. Because these challenges are not specific, we have assessed the serotonergic activity in BPD with the flesinoxan challenge. Preliminary results showed that the prolactine responses to flesinoxan were significantly lower in BPD patients compared to those observed in controls. [less ▲]

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See detailThe Use of Cardboard Bedding Material as Part of an Environmental Control Regime for Heaves-affected Horses: In Vitro Assessment of Airborne Dust and Aeroallergen Concentration and In Vivo Effects on Lung Function
Kirschvink, Nathalie; Di silvestro, F.; Sbai, Ilham ULg et al

in Veterinary Journal (2002), 163

This study aimed to test whether shredded cardboard is an appropriate minimum-dust bedding material for heaves-affected horses. Results of standardized in vitro measurement of airborne dust and ... [more ▼]

This study aimed to test whether shredded cardboard is an appropriate minimum-dust bedding material for heaves-affected horses. Results of standardized in vitro measurement of airborne dust and aeroallergen concentrations of cardboard bedding were significantly lower than those of common bedding materials. Six heaves-affected horses in clinical remission after pasturing were stabled for two months on cardboard bedding and fed grass silage. Pulmonary function tests (PFT: ventilatory mechanics, arterial blood gases, airway inflammation scoring, bronchoalveolar cytology) were performed before, during and after this period and after stabling the horses in poor hygienic conditions. PFT values measured during and after the stabling period on cardboard bedding were not significantly different from those recorded after the period at pasture or from those of healthy horses, but were significantly different from those recorded in poor hygienic conditions. On basis of the in vitro and in vivo results it can be concluded that cardboard bedding, used in conjunction with low-dust forage, may be appropriate in the provision of minimum-dust management of heaves-affected horses [less ▲]

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See detailIdentités et transactions réflexives. Une approche de l'identité des acteurs retraités
Vrancken, Didier ULg

in Recherches Sociologiques et Anthropologiques (2002), 2

A partir de l'identification d'une population, celle des retraités âgés entre 50 et 75 ans, population particulièrement confrontée à des problèmes de reconnaissance et d'identités sociales, cet article ... [more ▼]

A partir de l'identification d'une population, celle des retraités âgés entre 50 et 75 ans, population particulièrement confrontée à des problèmes de reconnaissance et d'identités sociales, cet article propose de repenser le concept d'identité en sociologie au départ d'un triple travail d'articulation identitaire qu'accomplirait l'acteur. Après avoir identifié une transaction narrative, une transaction argumentative, l'auteur dégage une troisième forme : celle de la tradition réflexive analysée à la suite de la tradition expressiviste allemande et de son dépassement par la critique herméneutique. C'est de cette triple articulation identitaire que rendrait compte une typologie proposée en conclusion. [less ▲]

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See detailLe dépassement du délai raisonnable en matière d'infraction à la législation sur les douanes et accises
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailActualites therapeutiques 2002 (1).
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(11), 719-31

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and ... [more ▼]

The most important drugs registered and/or launched in Belgium during the last year in the various disciplines of internal medicine will be briefly described. The main characteristics of each molecule and its modalities of appropriate use in clinical practice will be emphasized. For all these molecules, both the efficacy and tolerance have been proven in randomised clinical trials according to the rules of Evidence-Based Medicine. [less ▲]

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See detailInteraction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane.
Aguedo, Mario ULg; Beney, Laurent; Wache, Yves et al

in International journal of food microbiology (2002), 80(3), 211-5

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological ... [more ▼]

Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalactone was previously shown to have antimicrobial properties. We determined by infrared spectroscopy measurements that this compound rapidly diffused into model phospholipid bilayers (within 2 min), modifying the general physical state of a dimyristoyl-L-alpha-phosphatidylcholine (DMPC) film. In vivo, the lactone strongly increased membrane fluidity in the model yeast Yarrowia lipolytica, as evaluated by fluorescence anisotropy measurements. This effect was more important than that of benzyl alcohol, which is known as a fluidizing agent in living cells, and may explain the toxic action of gamma-decalactone in microorganisms. [less ▲]

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See detailLes bancs solaires au banc des accusés.
Uhoda, I.; Petite, Louicette ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(1), 29-32

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many ... [more ▼]

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many skin changes includes accelerated photoageing, irreversible pigmentary and keratotic changes, and cutaneous malignancies including malignant melanoma. In the absence of protection, the eye is also affected. Even if tanning salon exposure increases the risk for skin cancer by a small amount, it represents a significant potential public health hazard given the number of people attending salons. Digital dermoscopy and ultraviolet light videoscopy are new methods allowing to predict the cutaneous ransom to be paid by the sunbed worshippers. [less ▲]

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See detailDetection of illegal growth promoters in biological samples using receptor binding assays
Scippo, Marie-Louise ULg; Van de Weerdt, Cécile ULg; Willemsen, Philippe et al

in Analytica Chimica Acta (2002), 473(1-2), 135-141

In the European Union (EU), the use of growth-promoting substances in meat production is banned. The control of growth promoters, especially steroid hormones, is presently based on expensive and time ... [more ▼]

In the European Union (EU), the use of growth-promoting substances in meat production is banned. The control of growth promoters, especially steroid hormones, is presently based on expensive and time-consuming chromatographic methods of analysis or, sometimes, for screening purposes, on radio- or enzyme-immunoassays, all of which are often too specific to allow effective multi-analyte control. In order to develop rapid and inexpensive multi-analyte detection tests, we proposed the use of hormonal receptors as detection tools. The system described here (radio-receptor assays) is based on a direct bindin g assay of steroid hormones to their respective receptors. Human receptors to estrogens (hERalpha), androgens (hAR), progestagens (hPR) and glucocorticoids (hGR) have been produced by genetic engineering in bacteria or in eucaryotic cells. Binding analyses revealed that the obtained receptor proteins retained a high affinity for their corresponding native ligand. In addition, competition studies continued that each of the four receptors displays a specificity profile for a series of analogs in agreement with the literature. Finally, the stability of these recombinant receptors is sufficient to allow their use in test kits. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPostmenopausal aging of the sebaceous follicle: a comparison between women receiving hormone replacement therapy or not.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(1), 17-22

BACKGROUND: The endocrine control of sebaceous follicles is complex in women. During aging, a decline in sebum output is often experienced. However, some women report increased seborrhea after the ... [more ▼]

BACKGROUND: The endocrine control of sebaceous follicles is complex in women. During aging, a decline in sebum output is often experienced. However, some women report increased seborrhea after the menopause. OBJECTIVE: In this study, the follicular reservoir function was studied during the first decade following the menopause. METHODS: Four evaluations were made at 3-week intervals in two parallel age-matched groups of 50 postmenopausal women receiving hormone replacement therapy (HRT) or not. The Sebumeter served to measure the casual sebum level and the sebum excretion rate on the forehead. In addition, a Visioscan equipped with an ultraviolet-recording camera was used with and without lipid-sensitive tapes interposed between the camera and the skin surface. Follicular openings and sebum pore patterns were studied by image analysis. RESULTS: There was enormous diversity among individual values of sebum output at the skin surface. In untreated women, a significant decline in sebum excretion rate accompanied by an increase in both the sebum replacement time and the mean pore size were evidenced during the first decade after the menopause. The sebum excretion rate and casual level showed a wide range of interindividual differences early after the menopause. These physiological changes were less prominent in women receiving HRT. CONCLUSION: Postmenopausal aging affects the sebum production, but HRT does not significantly control the complex process of seborrhea. However, HRT mitigates the progressive enlargement of the openings of the sebum follicular reservoir. [less ▲]

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See detailPrognosis of hematologic malignancies does not predict intensive care unit mortality.
MASSION, Paul ULg; Dive, Alain M; Doyen, Chantal et al

in Critical Care Medicine (2002), 30(10), 2260-70

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic ... [more ▼]

OBJECTIVE: To evaluate the correlation between specific prognosis of hematologic malignancies on the one hand and intensive care unit and hospital mortality in critically ill patients with hematologic malignancies on the other hand. DESIGN: Observational study during a 10-yr period. SETTING: A 22-bed medical-surgical intensive care unit. PATIENTS: A total of 84 consecutive patients with nonterminal hematologic malignancies with medical complications requiring intensive care. INTERVENTIONS: None. MEASUREMENTS: Demographic factors, acute physiology and organ dysfunction scores, microbiology, therapeutic support, and hematologic factors data on admission and during the intensive care unit stay were collected, together with mortality follow-up. Based on specific-disease prognostic factors and related published survival curves, the prognosis of hematologic malignancies was assessed and defined as good, intermediate, or poor according to a 3-yr survival probability of >50%, 20-50%, or <20%, respectively. MAIN RESULTS: Prognosis of hematologic malignancies does not predict intensive care unit or hospital mortality and almost reaches significance for 6-mo mortality (53%, 71%, and 84% rate for patients with good, intermediate, and poor prognosis, respectively, p =.058), but it determines long-term survival (p =.008). Intensive care unit, hospital, and 6-mo overall mortality rates were 38%, 61%, and 75%, respectively. Using multivariate analysis, intensive care unit mortality was best predicted on admission by respiratory failure and fungal infection, whereas hospital mortality was predicted by the number of organ failures, the bone marrow transplant status, and the presence of fungal infection. The Acute Physiology and Chronic Health Evaluation II and the Simplified Acute Physiology Score II had no prognostic value, whereas the difference of the Multiple Organ Dysfunction Score between at the time of admission and at day 5 allowed quick prediction of hospital mortality. Diseases with the poorest 6-mo prognosis were acute myeloid leukemia and non-Hodgkin lymphoma. CONCLUSION The severity of the underlying hematologic malignancies does not influence intensive care unit or hospital mortality. Short-term prognosis is exclusively predicted by acute organ dysfunctions and by a pathogen's aggressiveness. Therefore, reluctance to admit patients with nonterminal hematologic malignancies to the intensive care unit based only on the prognosis of their underlying hematologic malignancy does not seem justified. [less ▲]

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See detailL'etude clinique du mois. La MRC/BHF Heart Protection Study.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 613-6

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily ... [more ▼]

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily or matching placebo. In addition to being randomized to compare simvastatin vs placebo, all patients were also randomized to compare antioxidant vitamin supplementation (vitamin E 600 mg/day, vitamin C 250 mg/day and betacarotene 20 mg/day) vs placebo in a "2 x 2 factorial" design. Duration of the study was 5 years. All-cause mortality was significantly reduced among patients allocated to simvastatin (-12.3%) due to a highly significant (-18%) reduction in the coronary death rate, a marginally significant reduction in other vascular deaths and a non-significant reduction in non-vascular deaths. There were highly significant reductions (of about one-quarter) in the first event rate for non-fatal myocardial infarction and coronary death (combined), for non-fatal and fatal stroke and for coronary or non-coronary revascularization. The beneficial effect of simvastatin was seen in all sub-categories which were studied and, particularly: women vs men; patients aged > 70 years vs those aged < 70 years; patients with LDL cholesterol < vs > 116 mg/dl, or total cholesterol < vs > 193 mg/dl. The treatment was well tolerated and the annual risk of myopathy was 0.01%. All comparisons between antioxidant vitamin supplementation and placebo failed to reveal any difference in favour or against the supplementation which was otherwise well tolerated. These important results and their implications will be briefly discussed. [less ▲]

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See detailGiovani autori crescono malgrado tutto
Delhalle, Nancy ULg

in Hystrio, trimestriale di teatro e spettacolo (2002), (2),

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See detailPieges et conseils a propos de l'utilisation des antidiabetiques oraux conventionnels.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 352-6

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of ... [more ▼]

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of severe hypoglycaemic episodes with sulphonylureas and to minimise the risk of lactic acidosis with metformin. These drugs, when used appropriately with respect of contra-indications, have an excellent safety profile and remain the basis of the treatment of type 2 diabetes. [less ▲]

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See detailA quinze ans, trop de jeunes sont brouillés avec la lecture
Lafontaine, Dominique ULg

in Caractères (2002), 7

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See detailEcueils et chausse-trapes.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 249

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See detailCollision-induced dissociation of 16-mer DNA duplexes with various sequences: evidence for conservation of the double helix conformation in the gas phase
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in International Journal of Mass Spectrometry (2002), 219(1), 151-159

The MS/MS of 11 different 16-mer non-self-complementary DNA duplexes with various sequences has been under-taken with a quadrupole-TOF hybrid instrument, The comparison of the dissociation yields for ... [more ▼]

The MS/MS of 11 different 16-mer non-self-complementary DNA duplexes with various sequences has been under-taken with a quadrupole-TOF hybrid instrument, The comparison of the dissociation yields for complexes having different amounts of GC base pairs, though complicated by side-reactions like single-strand fragmentation, confirms the effect of the number of GC base pairs. More importantly, for complexes containing the same fraction of GC and different base sequences, the fragmentation yield remarkably parallels the DeltaH(diss) in solution calculated by a nearest-neighbor model for B-DNA. In addition to specific hydrogen bonding interactions, base stacking interactions also seem to survive in the gas phase and the conformation is conserved in the gas phase. Moreover, we have studied the uneven partition of the negative charges between the single strands, which was found to be directed by the nature of the terminal bases exclusively, and correlated with the gas-phase acidities of the (sugar-phosphate-sugar-base) species. [less ▲]

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See detailUne étude inédite de Franz Cumont sur le vocabulaire des inscriptions funéraires chrétiennes de Gaule
Rochette, Bruno ULg

in Bulletin de l'Institut Historique Belge de Rome (2002), 72

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See detailLa prescription des pensions alimentaires: fin d'une controverse. Note sous Cass., 8 décembre 2000
Kohl, Benoît ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (2002)

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See detailResearch on Instruction in Physical Education. Review of the Research in Selected Roman Languages.
Piéron, Maurice ULg; Cloes, Marc ULg

in International Journal of Physical Education (2002), 39(1), 12-20

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in ... [more ▼]

In French, the term "intervention" is used since a few years. The paper will: (1) deal with the topic of instruction limites to teachers' decisions and interventions during the interactive phase in teaching; during this phase, activities planned in the pre-interactive phase are implemented: the interactive phase concerns the task's presentation, the pupils' activity and the control of this activity in terms of behavioural management and of the quality of the eprformance (feedback); (2) refer to the main research methods used in gathering data, and (3) develop the main findings in the domain of instruction: teacher thinking and behaviour, pupils' thoughts and behaviour, management of the class or in other words control of pupils' behaviour. It is evident that thougts and behaviours are closely related and are part of the relationship between teachers and pupils. The paper focused only on texts appearing in French, Portuguese and Spanish published since 1997 in Physical eeducation journals and Proceeddings of international congresses. [less ▲]

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See detailObservations sur l'adage: Periculum est emptoris
Gerkens, Jean-François ULg

in Cahiers du Centre de Recherches en Histoire du Droit et des Institutions (2002), (17), 117-133

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See detailImpact des méthodes d'application sur l'efficacité d'un traitement à base de Pichia anomala souche K contre les maladies de post-récolte des pommes
Jijakli, Haissam ULg; Dickburt, Catherine; Lepoivre, Philippe ULg et al

in VIII journées scientifiquesBiotechnologies végétales: valorisation pour une agriculture durable (2002)

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See detailPredicting transpiration from forest stands in Belgium for the 21st century
Misson, Laurent; Rasse, Daniel; Vincke, Caroline et al

in Agricultural and Forest Meteorology (2002), 111(4), 265-282

Canopy transpiration is a major element of the hydrological cycle of temperate forests. Levels of water stress during the 21st century will be largely controlled by the response of canopy transpiration to ... [more ▼]

Canopy transpiration is a major element of the hydrological cycle of temperate forests. Levels of water stress during the 21st century will be largely controlled by the response of canopy transpiration to changing environmental conditions. One year of transpiration measurement in two stands (Quercus robur L. and Fagus sylvatica L.) was used to calibrate the ASPECTS model on a(1) and D-0, two parameters of a modified version of Leuning's equation of stomatal conductance. A second year of data was used to validate the model. The results indicate a higher sensitivity of g(sc), to vapour pressure deficit (DS) in oak than in beech (D-0 (oak) < D-0 (beech)). To simulate future forest transpiration, site specific weather data sets were constructed from GCM outputs, spatially and temporally downscaled with local climatic data. Temperature increase between the end of the 20th and 21st centuries was predicted to be 2.8 degreesC in the beech stand and 3.1 degreesC in the oak stand. Based solely on temperature change, ASPECTS predicted an increase in transpiration of 17% in the beech and 6% in the oak stand, the difference being due to variation in local climate and the sensitivity of both species to D-s. Based solely on increased atmospheric CO2 (355 ppm in 1990 to 700 ppm in 2100), ASPECTS predicted that transpiration would decrease by 22% in beech and 19% in oak. With the combined scenarios of climatic change and increased atmospheric CO2, ASPECTS showed a decrease of 7% in transpired water in the oak stand and only 4% in the beech stand, which are not significant differences from zero. Consequently, water stress should not increase in either stand during the 21st century. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailComparaison des cahiers des charges de filières de production porcine sous « signe de qualité » en Région wallonne.
Degre, Aurore ULg; Verheve, Didier; Debouche, Charles ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(4), 221-230

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See detailA qui appartient le ragondin ?
Roussel, Laurence; Mougenot, Catherine ULg

in Espaces et Sociétés (Paris, France) (2002), (110-111), 225-247

La lutte contre le ragondin, espèce importée d'Amérique du Sud en Europe, aujourd'hui classée parmi les espèces invasives, a été inscrite simultanément dans deux législations différentes. Dans le ... [more ▼]

La lutte contre le ragondin, espèce importée d'Amérique du Sud en Europe, aujourd'hui classée parmi les espèces invasives, a été inscrite simultanément dans deux législations différentes. Dans le mondeagricole, c'est une action qui s'inspire de la guerre contre les ravageurs des cultures. Elle s'organise collectivement à l'aide d'un poison, la bromadiolone. Dans le monde de la chasse, elle est principalement du domaine des piégeurs. Solitaires, ceux-ci pourchassent le ragondin en tant qu'espèce nuisible. Cette division est héritée du Moyen Âge, de ses usages de l'espace et des droits qui leur étaient associés (droit de destruction pour les agriculteurs). Actuellement, l'espace rural peut être vu comme une mosaïque, òu ces deux principaux types de lutte coexistent, alors que certains milieux restent libres de toute intervention. Mais ces actions sont aussi l'objet de critiques qui mettent en cause l'utilisation de la bromadiolone et certaines formes de piégeage. Et aujourd'hui, on observe que les modalités de lutte contre le ragondin se combinent aux nouveaux usages de l'espace. [less ▲]

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See detailStudy of the early abortion in reciprocal crosses between Phaseolus vulgaris L. and Phaseolus polyanthus Greenm
Geerts, P.; Toussaint, André ULg; Mergeai, Guy ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(2), 109-119

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See detailEuclidean and fractal computer-assisted corneofungimetry: a comparison of 2% ketoconazole and 1% terbinafine topical formulations.
Arrese Estrada, Jorge ULg; Fogouang, L.; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(3), 222-7

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups ... [more ▼]

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups of 15 volunteers, corneofungimetry was used to compare the effect of 5-day b.i.d. treatments with 2% ketoconazole and 1% terbinafine creams. METHODS: The bioassay was performed using 10 isolates of each of the 3 fungi Trichophyton rubrum, T. mentagrophytes var. interdigitale and Candida albicans put to grow on human stratum corneum. Controls were stratum corneum either untreated or enriched in propylene glycol contained in an unmedicated vehicle. Quantitative assessments were made using both Euclidean and fractal geometry parameters. RESULTS: In comparison with untreated stratum corneum, the fungitoxic activity of the 2% ketoconazole and 1% terbinafine formulations was obvious and similar against dermatophytes. By contrast, 2% ketoconazole was significantly more active against C. albicans than 1% terbinafine. The propylene-glycol-containing vehicle did not exhibit a significant effect upon the dermatophyte growth. Positive linear correlations were yielded between the extent area and the fractal dimension D of dermatophyte mycelia. By contrast, D appeared unrelated to the relative area of dermatophyte growth compared to controls. CONCLUSION: The combination of Euclidean and fractal analyses improves the information provided by the corneofungimetry bioassay. Creams containing 2% ketoconazole and 1% terbinafine appear equally effective against dermatophytes while the former is more potent against Candida albicans. [less ▲]

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See detailQuelques résultats prometteurs pour une sylviculture de l'Aulne glutineux en Wallonie.
Claessens, Hugues ULg; Thibaut, A.; Rondeux, Jacques ULg

in Revue Forestière Française (2002), 54(3), 259-270

In Belgium, black alder is well known for its ecological functions, but is generally considered as a secondary species without any true economic value. The present study, based on data pertaining to 166 ... [more ▼]

In Belgium, black alder is well known for its ecological functions, but is generally considered as a secondary species without any true economic value. The present study, based on data pertaining to 166 plots, aims at evaluating the potential of black alder silviculture in the Walloon forest (Southern Belgium). We successively analysed dominant height growth, dominant girth growth and solid stem volume over time. It appears that by controlling competition within stands it should be possible to produce quality, 150-cm girth logs within 50 – 100 years, depending on the level of productivity. The German tables of Mitscherlich (in Schöber, 1975) seem to be most suitable for describing the growth parameters of the Belgian alder stands over time and black alder stand production can be estimated at 3 to 9 m3/ha/year according to site classes. We can conclude that black alder silviculture can be a viable economic activity. [less ▲]

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See detailBiospheric carbon stocks reconstructed at the Last Glacial Maximum: comparison between general circulation models using prescribed and computed sea surface temperatures
Otto, D.; Rasse, Daniel; Kaplan, J. et al

in Global and Planetary Change (2002), 33(1-2), 117-138

The terrestrial biosphere model Carbon Assimilation in the Biosphere (CARAIB) was improved by introducing two vegetation storeys and implementing a new module which simulates the equilibrium distribution ... [more ▼]

The terrestrial biosphere model Carbon Assimilation in the Biosphere (CARAIB) was improved by introducing two vegetation storeys and implementing a new module which simulates the equilibrium distribution of the vegetation inferred from physiological processes and climatic constraints. In this fourth version of CARAIB, we differentiate ground-level grasses from tree canopies, which allows us to determine the light available to grasses as a direct function of the leaf area index (LAI) of the forest canopy. Both of these storeys are potentially composed of several plant functional types (PFT). The cover fraction of each PFT within each storey is estimated according to its respective net primary productivity (NPP). A biome is assigned to each grid cell on the basis of three physiological criteria: (1) the cover fraction, (2) the NPP, and (3) the LAI; and two climatic constraints: (1) the growing degree-days (GDD) and (2) the lowest temperature reached during the cold season (T-min), which are well-known indices of vegetation expansion boundaries. Total biospheric carbon stocks (vegetation + soil) are reconstructed by forcing the model with eight climatic scenarios of the Last Glacial Maximum (LGM, 21 ka BP), which were obtained from the Palco-Modelling Intercomparison Project (PMIP) from four general circulation models (MRI2, UGAMP, LMD4, and GEN2) using prescribed and computed sea surface temperatures (SSTs). The model was also forced with a current climate together with a preindustrial atmospheric CO2 level of 280 ppm as reference simulation, To validate the model, current biome distribution is reconstructed and compared, for the modem climate, with two distributions of potential vegetation and, for the LGM, with pollen data. The model simulations are in good agreement with broad-scale patterns of vegetation distribution, The results indicate an increase in the total biospheric carbon stock of 827.8-1106.1 Gt C since the LGM. Sensitivity analyses were performed to discriminate the relative effects of the atmospheric CO, level ("fertilization effect"), the climate (present or LGM), and the sea level. Our results suggest that the CO, fertilization effect is mostly responsible for the total increase in vegetation and soil carbon stocks. The four GCMs diverged in their predicted responses of continental climate to calculated SSTs. Only one of them, i.e., MRI2, predicted a marked decline of the continental temperatures in response to lower calculated SSTs. For this GCM, the effect of reduced SSTs on continental biospheric carbon stocks was a decrease of 544.1 Gt for the soil carbon stock and of 283.7. [less ▲]

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See detailSternal recumbency or suspension by the hind legs immediately after delivery improves respiratory and metabolic adaptation to extra uterine life in newborn calves delivered by caesarean section.
Uystepruyst, Christophe; Coghe, Joost; Dorts, Thierry et al

in Veterinary Research (2002), 33(6), 709-724

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian ... [more ▼]

The aim of this study was to evaluate the effect of body positioning immediately after delivery on respiratory and metabolic adaptation to extra-uterine life in newborn calves. One hundred and one Belgian White and Blue calves were delivered at term by an elective caesarean section and were assigned into three categories according to the body position imposed immediately after umbilical cord rupture: 71 calves were placed in lateral recumbency; 16 calves were placed in sternal recumbency and 14 calves were suspended by the hind legs for less than 90 seconds (75 +/- 5 s). Following this initial body position, the calves were allowed to move without restraint. They were examined at birth, 5, 15, 30, 45 and 60 minutes, and 2, 3, 6, 12 and 24 hours after birth by the following measurements: physical examination, heart rate, arterial blood gas analysis, pulmonary function tests using the esophageal balloon catheter technique, arterial and venous blood acid-base balance analysis, rectal temperature, jugular venous blood sampling for the determination of blood glucose, plasma lactate and serum cortisol concentrations, haematologic variables and passive immune transfer variables. Body positioning immediately after delivery clearly influenced respiratory and metabolic adaptation to extra-uterine life in term calves delivered by an elective caesarean section. Systematic sternal recumbency and suspension by the hind legs for less than 90 seconds immediately after umbilical cord rupture had a positive functional impact on postnatal pulmonary mechanics and gas exchange and on postnatal correction of mixed acidosis present at birth, contributing in turn to an enhanced passive immune transfer. These two body positions should be encouraged to improve adaptation at birth in healthy term calves delivered by an elective caesarean section. Evaluation of possible side-effects is required before application in severely asphyxiated calves. [less ▲]

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See detailComment j'explore ... une métastase orpheline d'un mélanome.
Henry, Frédérique ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(6), 405-7

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then ... [more ▼]

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then be performed using non invasive and clinically oriented methods. Beside a thorough skin examination, otorhinolaryngological, ophtalmic and gynecologic searches are recommended. In addition, paraclinical investigations are conducted according to the metastatic location, the gender and the functional complaints of the patient. The prognosis of these orphan metastases is not more dramatic than when the primary lesion is identified. Therapies are similar to those proposed in the classical presentation of the disease. [less ▲]

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See detailCD40 engagement enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 expression: Possible involvement in allergic inflammation.
Bureau, Fabrice ULg; Seumois, Gregory; Jaspar, Fabrice et al

in Journal of Allergy and Clinical Immunology (The) (2002), 110(3), 443-9

BACKGROUND: CD40 engagement enhances eosinophil survival, suggesting a role for this receptor in the development of eosinophilia. OBJECTIVE: We examined whether CD40 enhances eosinophil survival by ... [more ▼]

BACKGROUND: CD40 engagement enhances eosinophil survival, suggesting a role for this receptor in the development of eosinophilia. OBJECTIVE: We examined whether CD40 enhances eosinophil survival by inducing the expression of antiapoptotic proteins. Three members of the inhibitor of apoptosis protein (IAP) family, namely cellular (c)-IAP1, c-IAP2, and XIAP, and 2 antiapoptotic proteins of the Bcl-2 family, namely Bcl-x(L) and Bfl-1/A1, were investigated. METHODS: Blood and sputum were obtained from healthy subjects and atopic asthmatic patients. Blood eosinophils were isolated by means of magnetic selection. Expression of CD40, IAPs, and Bcl-2 proteins was investigated by using flow cytometry, immunoblotting, or both. CD40 stimulation was achieved with agonistic antibodies or soluble ligands. Apoptosis was assessed by staining with propidium iodide and FITC-conjugated annexin-V. c-IAP2 expression was inhibited with antisense oligonucleotides. RESULTS: Freshly isolated eosinophils from healthy and asthmatic patients did not express CD40. Conversely, eosinophils expressed CD40 spontaneously when cultured for 48 hours. At this time point, CD40 stimulation significantly delayed eosinophil apoptosis. Inhibition of eosinophil apoptosis was accompanied by induction of c-IAP2 but not c-IAP1, XIAP, Bcl-x(L), or Bfl-1/A1 expression. Antisense knockdown of c-iap2 abolished CD40-induced enhancement of eosinophil survival. Sputum cells from asthmatic patients, unlike those from healthy subjects, substantially expressed CD40 and c-IAP2. Moreover, a strong correlation was found between the percentage of eosinophils in the sputum from asthmatic patients and the sputum level of CD40 and c-IAP2 expression. CONCLUSION: The results demonstrate that CD40 engagement enhances eosinophil survival through induction of c-IAP2 expression and suggest a role for this mechanism in allergic inflammation. [less ▲]

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See detailKeratinocyte injury in drug-induced toxic epidermal necrolysis: Simultaneous but distinct topographic expression of CD95R and calprotectin.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(2), 145-7

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the ... [more ▼]

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the apoptotic pathomechanism involving calprotectin and the CD95 receptor (CD95R, FasR) in TEN. The expression of these two molecules corresponds to calcium-dependent and calcium-independent processes, respectively. Biopsies were collected from blistering skin in 21 TEN patients and from clinically uninvolved skin in 16 of these patients. Immunohistochemistry was performed using specific antibodies directed to CD95R and calprotectin. Half (8/16) of the biopsy specimens taken from clinically uninvolved sites showed the expression of calprotectin throughout the epidermis or restricted to the suprabasal layers. In these samples, a strong CD95R immunoreactivity was often restricted to the basal layer (8/16). Calprotectin was present in all biopsies of bullous skin, especially in suprabasal layers (15/21) or throughout the epidermis (6/21). By contrast, the prominent expression of CD95R was confined almost exclusively to the basal layer (15/21), and more rarely throughout the epidermis (2/21), and it remained sometimes unexpressed (4/21). A clear-cut boundary was often present between the areas labeled by the two antibodies with exceptional overlap between them. The simultaneous expression of calprotectin and CD95R in TEN at distinct levels of the epidermis indicates that the pathomechanism leading to keratinocyte death does not belong to a single process in TEN. Their expression in clinically uninvolved skin suggests that these processes are early and widespread events in TEN. [less ▲]

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See detailCharacterization of porous texture of hyperporous materials by mercury porosimetry using densification equation
Pirard, René ULg; Alié, Christelle ULg; Pirard, Jean-Paul ULg

in Powder Technology (2002), 128(2-3), 242-247

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury ... [more ▼]

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury; instead, it shrinks under the mercury isostatic pressure and its density increases. The phenomenon is partially or completely irreversible. The proposed method enables computing the pore volume distribution as a function of the pore size in the same way as Washburn's method does in the case of mercury intrusion. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPrévention des cancers cutanés par les crèmes de protection solaire.
Uhoda, I.; Pierard, Claudine ULg; Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(8), 505-8

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only ... [more ▼]

How do sunscreens protect against skin cancers? The answer to this question is a matter of controversy among scientist for several years. The doubt persists because the wise use of such products is only one of the factors involved in sun behavior together with avoiding excessive sunlight exposure and wearing protective clothes. [less ▲]

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See detailThe multivariate Dale model and genetic associations
Van Steen, Kristel ULg; Molenberghs, G.; Tahri, N.

in American Journal of Human Genetics (2002), 71

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See detailSkin manifestations of Bartonella infections.
Chian, Cesar A; Arrese Estrada, Jorge ULg; Pierard, Gérald ULg

in International Journal of Dermatology (2002), 41(8), 461-6

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See detailPhylogeny and Morphological Evolution of the Amblystegiaceae (Bryopsida)
Vanderpoorten, Alain ULg; Hedenäs, L.; Cox, C. J. et al

in Molecular Phylogenetics & Evolution (2002), 23

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See detailThe formation and function of extracellular enveloped vaccinia virus
Smith, G. L.; Vanderplasschen, Alain ULg; Law, M.

in Journal of General Virology (The) (2002), 83

Vaccinia virus produces four different types of virion from each infected cell called intracellular mature virus (IMV), intracellular enveloped virus (IEV), cell-associated enveloped virus (CEV) and ... [more ▼]

Vaccinia virus produces four different types of virion from each infected cell called intracellular mature virus (IMV), intracellular enveloped virus (IEV), cell-associated enveloped virus (CEV) and extracellular enveloped virus (EEV). These virions have different abundance, structure, location and roles in the virus life-cycle. Here, the formation and function of these virions are considered with emphasis on the EEV form and its precursors, IEV and CEV. IMV is the most abundant form of virus and is retained in cells until lysis; it is a robust, stable virion and is well suited to transmit infection between hosts. IEV is formed by wrapping of IMV with intracellular membranes, and is an intermediate between IMV and CEV/EEV that enables efficient virus dissemination to the cell surface on microtubules. CEV induces the formation of actin tails that drive CEV particles away from the cell and is important for cell-to-cell spread. Lastly, EEV mediates the long-range dissemination of virus in cell culture and, probably, in vivo. Seven virus-encoded proteins have been identified that are components of IEV, and five of them are present in CEV or EEV. The roles of these proteins in virus morphogenesis and dissemination, and as targets for neutralizing antibody are reviewed. The production of several different virus particles in the VV replication cycle represents a coordinated strategy to exploit cell biology to promote virus spread and to aid virus evasion of antibody and complement. [less ▲]

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See detailIn vivo manganese-enhanced magnetic resonance imaging reveals connections and functional properties of the songbird vocal control system
Van der Linden, A.; Verhoye, M.; Van Meir, V. et al

in Neuroscience (2002), 112(2), 467-474

Injection of manganese (Mn2+), a paramagnetic tract tracing agent and calcium analogue, into the high vocal center of starlings labeled within a few hours the nucleus robustus archistriatalis and area X ... [more ▼]

Injection of manganese (Mn2+), a paramagnetic tract tracing agent and calcium analogue, into the high vocal center of starlings labeled within a few hours the nucleus robustus archistriatalis and area X as observed by in vivo magnetic resonance imaging. Structures highlighted by Mn2+ accumulation assumed the expected tri-dimensional shape of the nucleus robustus archistriatalis and area X as identified by classical histological or neurochemical methods. The volume of these nuclei could be accurately calculated by segmentation of the areas highlighted by Mn2+. Besides confirming previously established volumetric sex differences, Mn2+ uptake into these nuclei revealed new functional sex differences affecting Mn2+ transport. A faster transport was observed in males than in females and different relative amounts of Mn2+ were transported to nucleus robustus archistriatalis and area X in males as compared to females. This new in vivo approach, allowing repeated measures, opens new vistas to study the remarkable seasonal plasticity in size and activity of song-control nuclei and correlate neuronal activity with behavior. It also provides new insights on in vivo axonal transport and neuronal activity in song-control nuclei of oscines. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved. [less ▲]

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