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See detailadministration en dose unique journalière de l'amikacine. Adaptation à la néonatalogie pour des enfants traités avant le 3° jour d'âge postnatal
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Médecine et Maladies Infectieuses (1993), 23

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See detailPalynological age for the lower part of the Hangenberg Shales in Sauerland, Germany
Higgs, K; Streel, Maurice ULg

in Annales de la Société Géologique de Belgique (1993), 116(Z), 243-247

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See detailStructure sociologique de l'élecotrat écologiste en Wallonie : une première exploration
Jacquemain, Marc ULg; Vandekeere, Michel; Doutrelepont, René

in Res Publica (1993), 25

The paper describes the main characteristics of ecological constituency through results of surveys. It shows how ecologist voter differ sharply from the rest of the population beeing much younger and much ... [more ▼]

The paper describes the main characteristics of ecological constituency through results of surveys. It shows how ecologist voter differ sharply from the rest of the population beeing much younger and much more educated, e.a. [less ▲]

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See detailSYNCYTIOTROPHOBLASTIC LOCALIZATION OF THE HUMAN GROWTH-HORMONE VARIANT MESSENGER-RNA IN THE PLACENTA
Scippo, Marie-Louise ULg; Frankenne, Francis ULg; HOOGHEPETERS, ELisabeth et al

in Molecular & Cellular Endocrinology (1993), 92(2), 7-13

The hGH/hCS genes, clustered on chromosome 17 in the 5' to 3' order GH-N, CS-L, CS-A, GH-V and CS-B, show a high degree of sequence identity. The expression product of the GH-V gene is the placental ... [more ▼]

The hGH/hCS genes, clustered on chromosome 17 in the 5' to 3' order GH-N, CS-L, CS-A, GH-V and CS-B, show a high degree of sequence identity. The expression product of the GH-V gene is the placental growth hormone, which replaces pituitary GH in maternal blood throughout pregnancy. By means of mRNA competitive hybridization using P-32-labelled and unlabelled 30 bases long oligonucleotides, we first optimized specific hybridization conditions. In situ hybridization was then performed to locate the GH-V mRNA encoding placental growth hormone. The hGH-V gene appears expressed in the placental syncytiotrophoblast. Unlike the CS-A and CS-B genes (both encoding hPL) which are expressed uniformly in the syncytiotrophoblast, the GH-V mRNA is located in a few syncytiotrophoblast cells only. [less ▲]

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See detailApplying the Lagamine model to compute land subsidence in Shanghai
Dassargues, Alain ULg; Schroeder, Christian ULg; Li, Xiang Lin

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailAtomic data and the spectrum of the solar photosphere.
Grevesse, Nicolas ULg; Noels-Grötsch, Arlette ULg

in Physica Scripta (1993), 47

Even though the solar photospheric abundances are now on the whole in very good agreement with the meteoritic values, some problems remain which will only be solved with a higher level of accuracy in the ... [more ▼]

Even though the solar photospheric abundances are now on the whole in very good agreement with the meteoritic values, some problems remain which will only be solved with a higher level of accuracy in the atomic data, especially the transition probabilities for faint lines. The authors justify this request for many more very accurate gf-values through a few particularly striking points. [less ▲]

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See detailEnhancement of metastatic potential of murine and human melanoma cells by laminin receptor peptide G: attachment of cancer cells to subendothelial matrix as a pathway for hematogenous metastasis.
Taraboletti, G.; Belotti, D.; Giavazzi, R. et al

in Journal of the National Cancer Institute (1993), 85(3), 235-40

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly ... [more ▼]

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly plays a crucial role in this event, the exact interactive pathways among cancer cells, laminin, and the vessel wall have not been elucidated. In a previous study, we identified synthetic peptide G, which contains the laminin-binding domain of the 67-kd laminin receptor and which inhibits tumor cell adhesion to endothelial cells. PURPOSE: To assess the role of the interaction between laminin and the 67-kd laminin receptor in hematogenous metastasis formation, we studied the effect of peptide G on melanoma cell behavior in vivo and in vitro. METHODS: The effect of peptide G and control peptides was studied in vivo on lung retention and colonizing potential of murine (B16BL6) and human (A2058) melanoma cells injected intravenously in C57BL/6 and nude mice, respectively. In addition, their effect on cell adhesion and chemotaxis to laminin and on binding of iodine 125-labeled laminin to cells was studied in vitro. RESULTS: In vivo, pretreatment of cells with peptide G resulted in a two- to 10-fold significant increase in the number of experimental lung metastases. A significant relative increase in lung retention of peptide G-treated tumor cells was observed 48 hours after injection, although after 4 hours a partial reduction was observed. In vitro, peptide G significantly increased laminin binding and cancer cell adhesion to laminin and subendothelial matrix, whereas chemotaxis to laminin was significantly inhibited. CONCLUSIONS: Peptide G differentially affected the biological response of cancer cells to laminin. In vitro, it increased laminin binding and cell adhesion to laminin and subendothelial matrix, whereas it inhibited cell chemotaxis to laminin. In vivo, the overall effect of peptide G was an augmentation of lung metastasis. IMPLICATIONS: Our findings suggest that direct adhesion of tumor cells to the subendothelial matrix is a main pathway for hematogenous metastases and that tumor cell-matrix interaction may be more relevant than tumor cell-endothelial cell attachment in this process. [less ▲]

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See detailComparison between culture of bovine embryos in vitro versus development in rabbit oviducts and in vivo
Ectors, Fabien ULg; Thonon, Fabienne; Delval, Alain et al

in Livestock Production Science (1993), 36

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC ... [more ▼]

The aim of this work was to evaluate the efficiency of different embryo culture methods for in vitro embryo production: development in co-culture with bovine oviductal epithelial cells (BOEC), in BOEC conditioned medium (CM) or in rabbit oviducts, versus in vivo produced embryos. There was no significant difference in terms of percentages of cleaved and 8-cell stages obtained between CM and BOEC. In CM, 24.8% of the cleaved embryos became blastocysts. In BOEC, 14.5% of the cleaved embryos became blastocysts. Among the 190 zygotes transferred in the rabbit oviducts, 127 have been recovered 5 days later, and 17.4% became blastocysts. There was no significant difference in term of blastocyst formation between the development in rabbit and in BOEC. However, there was a significant difference between the CM group and the two other groups. The numbers of cells in blastocysts from different sources were investigated: in vivo blastocysts contained 107 cells assumed to be 100%, in vitro blastocysts developed in rabbit oviduct 100.1 cells (93.3%), BOEC blastocysts 90.8 cells (84.6%) and CM blastocysts 72.3 cells (67.3%). This study confirmed earlier works on the oviduct effect on blastocyst quality in terms of development rate and cell number. [less ▲]

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See detailThe Implications of European Union for the Performance of Public Enterprises
Gathon, Henry-Jean ULg; Pestieau, Pierre ULg

in Administration : Journal of the Institute of Public Administration of Ireland (1993), 41(Summer), 149-165

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See detailCompte-rendu de l'ouvrage : Avignon au Moyen Age. Textes et documents
Xhayet, Geneviève ULg

in Moyen Age (Le) (1993), 99

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See detailIsopyoverdin Pp BTP1, a biogenetically interesting novel siderophore from Pseudomonas putida
Jacques, Philippe; Gwose, Inga; Seinsche, Dieter et al

in Natural Product Letters (1993), 3

From the cultures of Pseudomonas putida BTP 1 a siderophore could be isolated which contains the chromophore 2a rather than 1a typical for pyoverdins. Its structure was elucidated by MS, NHR and chemical ... [more ▼]

From the cultures of Pseudomonas putida BTP 1 a siderophore could be isolated which contains the chromophore 2a rather than 1a typical for pyoverdins. Its structure was elucidated by MS, NHR and chemical degradation. This new structural type is of great interest. The currently accepted biogenetic pathway leading to 1a starts from D-Tyr and L-Dab which condense to give the ferribactin chromophore 4. Subsequent ring closure via the -nitrogen of Dab leads to 1a while alternative ring closure via the -nitrogen would yield 2a. It is for the first time that this iso-chromophore has been detected in a Pseudomonas siderophore. Its discovery confirms the assumed intermediacy of ferribactine in the biogenesis of pyoverdins. [less ▲]

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See detailWanze/Huccorgne: Station de l'Hermitage
Noiret, Pierre ULg

in Chronique de l'Archéologie wallonne (1993), 1

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See detailConfidence levels of correlations between miospore biohorizons and standard conodont zones during Middle and Late Devonian time.
Streel, Maurice ULg; Loboziak, S

in Newsletter. Subcommission on Devonian Stratigraphy (1993), 10

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See detailPeut-on réfléchir sereinement sur les migrations humaines ?
Martiniello, Marco ULg

in Agenda Interculturel (1993), 113

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See detailRestriction Maps of the DNA of Cervid Herpesvirus 1 and Cervid Herpesvirus 2, Two Viruses Related to Bovine Herpesvirus 1
Vanderplasschen, Alain ULg; Bublot, M.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1993), 128(3-4), 379-88

Restriction maps of cervid herpesviruses 1 and 2 which are antigenetically related to bovine herpesvirus 1, were deduced from Southern blot hybridization with HindIII restriction fragments of BHV-1 DNA as ... [more ▼]

Restriction maps of cervid herpesviruses 1 and 2 which are antigenetically related to bovine herpesvirus 1, were deduced from Southern blot hybridization with HindIII restriction fragments of BHV-1 DNA as probes. [less ▲]

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See detailConstruction of a bovine genomic library of large yeast artificial chromosome clones
Libert, F.; Lefort, A.; Okimoto, R. et al

in Genomics (1993), 18(2), 270-276

We have constructed a yeast artificial chromosome (YAC) library derived from bull fibroblasts in primary culture. The library consists of 21,500 clones arranged on 224 gridded plates (96 or 8×12 positions ... [more ▼]

We have constructed a yeast artificial chromosome (YAC) library derived from bull fibroblasts in primary culture. The library consists of 21,500 clones arranged on 224 gridded plates (96 or 8×12 positions) and in 2×224 96-well microplates maintained as permanent frozen stocks. An average insert size of 750 kb was estimated from the analysis of 200 randomly selected YACs, giving a sixfold coverage of the bovine genome for the total library. A screening strategy based on the polymerase chain reaction that allows the identification of individual clones has been devised. Screening of the library with six locus-specific markers of interest led to the isolation of 34 positive clones [less ▲]

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See detailMonoamine Oxidase Inhibitors and Anesthesia: An Updated Literature Review
Blom-Peters, L.; Lamy, Maurice ULg

in Acta Anaesthesiologica Belgica (1993), 44(2), 57-60

Safe anesthesia for patients taking MAOIs has been possible since the 1980s using judicious choice of agents. The introduction of a new class of MAOIs (RIMA) has increased the margin of safety for these ... [more ▼]

Safe anesthesia for patients taking MAOIs has been possible since the 1980s using judicious choice of agents. The introduction of a new class of MAOIs (RIMA) has increased the margin of safety for these anesthetics. These drugs allow selective and rapidly reversible inhibition of type A-MAO. The pharmacologic effects of this new class of drug as well as their potential interactions with agents used in anesthesia are reviewed. [less ▲]

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See detailOlfactory receptors are displayed on dog mature sperm cells
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Journal of Cell Biology (1993), 123

Olfactory receptors constitute a huge family of structurally related G protein-coupled receptors, with up to a thousand members expected. We have shown previously that genes belonging to this family were ... [more ▼]

Olfactory receptors constitute a huge family of structurally related G protein-coupled receptors, with up to a thousand members expected. We have shown previously that genes belonging to this family were expressed in the male germ line from both dog and human. The functional significance of this unexpected site of expression was further investigated in the present study. We demonstrate that a few dog genes representative of various subfamilies of olfactory receptors are expressed essentially in testis, with little or no expression in olfactory mucosa. Other randomly selected members of the family show the expected site of expression, restricted to the olfactory system. Antibodies were generated against the deduced amino acid sequence of the most abundantly expressed olfactory receptor gene in dog testis. The purified serum was able to detect the gene product (DTMT receptor) in late round and elongated spermatids, as well as in the cytoplasmic droplet that characterizes the maturation of dog sperm cells, and on the tail midpiece of mature spermatozoa. Western blotting further confirmed the presence of a 40-kD immunoreactive protein in the membrane of mature sperm cells. Altogether , these results demonstrate that the main expression site of a subset of the large olfactory receptor gene family is not olfactory mucosa but testis. This expression correlates with the presence of the corresponding protein during sperm cell maturation, and on mature sperm cells. The pattern of expression is consistent with a role as sensor for unidentified chemicals possibly involved in the control of mammalian sperm maturation, migration, and/or fertilization [less ▲]

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See detailLa gestion de l'espace - Avant-propos
Bock, Laurent ULg

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3), 115-119

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See detailComparing measures of poverty and relative deprivation: an example for Belgium
Delhausse, Bernard; Luttgens, Axel; Perelman, Sergio ULg

in Journal of Population Economics (1993), 6

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of ... [more ▼]

This paper presents three different poverty standards. A first approach takes the disposable income as an indicator of poverty. A second approach uses the Leyden approach. Finally an aggregate index of deprivation, based on the observation of consumption events, is constructed through a particular econometric procedure proposed by Desai and Shah (1988). These alternative measures are then compared on a sample composed of 6380 Belgian households. Such an analysis can be expected to provide some further insight into the problem of measuring poverty, which has been the subject of a recent controversial debate. [less ▲]

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1993), 1

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements ... [more ▼]

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailNormal Electro- and Vectorcardiographic Data in the Growing Friesian Calf Using a Semi-Orthogonal Lead System
Amory, Hélène ULg; Genicot, B; Rollin, Frédéric ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40(2), 81-92

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were ... [more ▼]

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were recorded from healthy Friesian calves aged from one week to one year. Waveform and duration were analysed and compared in the X-, Y- and Z-leads. The modal P, QRS and T tridimensional vectors were graphically constructed and their magnitude and orientation were calculated. The duration of waves and intervals were similar to data previously reported in the bovine species. Differences from data reported in other species were attributed to heart rate. The duration of waves and QT and ST intervals significantly lengthened with the decrease in heart rate which occurred during growth. PR interval significantly lengthened with physical maturation, and this change was independent of the decrease in heart rate. The magnitude and the orientation of the spatial modal vectors were approximately similar to the few data previously reported in cattle and in other ungulates and were not affected by somatic growth [less ▲]

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See detailLes mécanismes biochimiques développés par les Pseudomonas fluorescents dans la lutte biologique contre les maladies des plantes transmises par le sol
Jacques, Philippe; Delfosse, Philippe; Ongena, MARC ULg et al

in Cahiers Agricultures (1993), 2

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See detailIdentification of 108k, 93k, and 42k Glycoproteins of Bovine Herpesvirus-1 by Monoclonal Antibodies
Baranowski, E.; Dubuisson, J.; Pastoret, Paul-Pierre ULg et al

in Archives of Virology (1993), 133(1-2), 97-111

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of ... [more ▼]

Three glycoproteins of bovine herpesvirus-1 (BHV-1) other than glycoproteins gI, gIII, and gIV were identified by monoclonal antibody (MAb) analyses. Monoclonal antibodies were obtained by immunization of mice with either BHV-1 envelope or virus infected cells, from which the glycoproteins gI, gIII, and gIV were removed by immunoaffinity. In the latter immunization procedure mice were tolerized either against normal cellular antigens with or without glycoproteins gI, gIII, gIV, and nucleocapsid. From 154 anti-BHV-1 hybridomas isolated, 39 MAbs precipitated a 108K glycoprotein. Two other glycoproteins of respectively 42K and 93K were precipitated each by one MAb. These three glycoproteins were detected in infected cell lysate. Nine anti-108K glycoprotein MAbs neutralized BHV-1 infectivity and three non-neutralizing MAbs were able to reduce plaque development when virus was grown in the presence of these MAbs. It is therefore suggested that this glycoprotein is involved in viral entry into the cell and in cell-to-cell spread of the virus. [less ▲]

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See detailHormonal regulation of adult partner preference behavior in neonatally ATD-treated male rats.
Bakker, Julie ULg; Brand, T.; van Ophemert, J. et al

in Behavioral Neuroscience (1993), 107(3), 480-7

Male rats, neonatally treated with ATD (1,4,6-androstatriene-3,17-dione), which blocks the aromatization of testosterone into estradiol (E2), were tested for adult partner preference behavior (PPB ... [more ▼]

Male rats, neonatally treated with ATD (1,4,6-androstatriene-3,17-dione), which blocks the aromatization of testosterone into estradiol (E2), were tested for adult partner preference behavior (PPB; estrous female vs. active male). Castration caused a decrease in preference for the female partner in all males, with ATD males showing lower preference for the female partner than controls. Long-term castrated males did not show preference for either partner. Precastration levels of PPB in control males occurred after treatment with E2 or dihydrotestosterone (DHT) plus E2. DHT alone had no effect on PPB. With E2 alone, the ATD males clearly preferred the male partner. When DHT was added, these ATD males showed no preference for either partner or a low preference for the female partner. In conclusion, adult PPB in male rats is activated by endogenous testosterone or by both its metabolites (DHT and E2) or by E2 alone. ATD males showed a much lower preference for the female. There was a differential effect of DHT and E2: DHT had no effect, but E2 clearly caused ATD males to prefer the male partner and control males to prefer the female partner. [less ▲]

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See detailEustatic Cycles around the Devonian-Carboniferous Boundary and the sedimentary and fossil record in Sauerland (Federal Republic of Germany).
Bless, M.J.M.; Becker, R.T.; Higgs, K et al

in Annales de la Société Géologique de Belgique (1993), 115(2), 689-702

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See detailElimination des métaux lourds par précipitation biologique
Toye, Dominique ULg; Schlitz, Marc; Crine, Michel ULg

in Tribune de l'Eau (La) (1993), 565

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See detailL'apprentissage précoce des langues étrangères par la méthode 'immersive'
Comblain, Annick ULg; Rondal, Jean-Adolphe ULg

in Rééducation Orthophonique (1993), 31

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See detailLa gestion de l'espace
Bock, Laurent ULg

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3), 115-414

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See detailComputed subsidence of the central area of Shanghai
Dassargues, Alain ULg; Radu, Jean-Pol ULg; Charlier, Robert ULg et al

in Bulletin of Engineering Geology & the Environment (1993), 47

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See detailPour une didactique des sources audiovisuelles
Jadoulle, Jean-Louis ULg

in Histoire et Enseignement : Bulletin (1993), 43e année(n°4), 11-13

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See detailCloning and characterization of G protein-coupled receptors
Parmentier, M.; Libert, F.; Perret, J. et al

in Advances in Second Messenger and Phosphoprotein Research (1993), 28

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See detailEvaluation of efficacy and safety of oral tiludronate in Paget's disease of bone: a double-blind, dose-ranging, placebo-controlled study
Reginster, Jean-Yves ULg; Colson, F; Morlock, G et al

in Arthritis and Rheumatism (1993), 36

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See detailFurther studies on the genetic diversity of lima beans (Phaseolus lunatus L.) using allozymes
Maquet, Alain; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (1993), 36

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See detailLaminin Receptors and Laminin-Binding Proteins During Tumor Invasion and Metastasis
Castronovo, Vincenzo ULg

in Invasion & Metastasis (1993), 13(1), 1-30

Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. These interactions ... [more ▼]

Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. These interactions are mediated through a large variety of cell surface proteins designated as laminin receptors and/or laminin-binding proteins. The growing number of identified laminin binding proteins and domains of this glycoprotein that are biologically active illustrate the complexity of cellular interactions with laminin. The 67-kD laminin receptor (67 LR) was the first protein identified in 1983 as a high-affinity laminin receptor, and its expression is dramatically increased in a large variety of cancer cells. The 67 LR is the subject of several controversies and confusion generated mainly by two events. First, the identification of several new laminin-binding proteins has raised the difficult task of attributing specific functions to specific receptors in contrast to initial beliefs that all cellular laminin-driven biological activities were mediated through the 67 LR. The second source of controversy is the large molecular-weight discrepancy between the 37-kD polypeptide encoded by the 67 LR cDNA clone and the mature 67 LR. In this manuscript, a critical and extensive review of the data accumulated on the 67 LR is presented regarding both its molecular structure and its role during tumor invasion and metastasis. A hypothetical model of the 67 LR is also proposed. Since the first identification of the 67 LR, at least 14 other cell surface molecules have been reported to be potential laminin receptors or laminin-binding proteins. These include members of the beta-galactoside-binding lectin family, seven members of the integrin family, the galactosyltransferase and some not yet fully characterized cell surface molecules. These laminin receptors and laminin-binding proteins are also described and their functions are also discussed with a particular emphasis on their participation in the constitution of the invasive phenotype. [less ▲]

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See detailL’enquête nationale sur les effectifs du cheptel au Burkina Faso
Bahili, Jean; Djaby, Bakary ULg

in Stateco (1993), 73

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See detailPalynological data from the Devono-Carboniferous boundary beds in the new Stockum Trench II and the Hasselbachtal Borehole. Northern Rhenish Massif, Germany.
Higgs, K; Streel, Maurice ULg; Korn, D et al

in Annales de la Société Géologique de Belgique (1993), 115(2/1992), 551-557

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See detailEvaluation isocinétique des genoux ligamentaires en pré et postopératoire
Croisier, Jean-Louis ULg; Delcour, J. P.; Dupont, Géraldine ULg et al

in Lettre de Médecine Physique et de Réadaptation (1993), 29

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See detailMiddle and Upper Devonian Miospore Zonation of Eastern Europe.
Avkhimovitch, V.I.; Tchibrikova, E.V.; Obukhovskaya, T.G. et al

in Bull. Centres Rech. Explor.-Prod. Elf Aquitaine, (1993), 17

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See detailLe traitement des adénomes à prolactine : utilisation d'un nouvel agoniste dopaminergique à longue durée d'action, la cabergoline, chez 56 patients
Beckers, Albert ULg; Abs, R.; Demez, Pierre ULg et al

in Médecine et Hygiène (1993), 51(1990), 1978-1980

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de ... [more ▼]

Nous avons utilisé la cabergoline, un nouvel agoniste dopaminergique, dans le traitement des adénomes hypophysaires à prolactine. Cinquante-six patients atteints de micro-adénome dans 35 cas et de macroadénome dans 21 cas ont été traités durant des périodes variant entre 1 et 17 mois à des doses de cabergoline variant entre 0,25 mg et 2 mg par semaine, prises à raison de 1 à 4 fois par semaine. Cette nouvelle substance nous est apparue extrêmement efficace et très bien tolérée [less ▲]

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See detailInsulin secretion, clearance, and action on glucose metabolism in cirrhotic patients.
Letiexhe, Michel ULg; Scheen, André ULg; Gerard, Pascale ULg et al

in Journal of Clinical Endocrinology and Metabolism (1993), 77(5), 1263-8

To study the mechanisms of glucose intolerance and hyperinsulinism in liver cirrhosis, we compared the plasma glucose, insulin, and C-peptide levels during a frequently sampled i.v. glucose tolerance test ... [more ▼]

To study the mechanisms of glucose intolerance and hyperinsulinism in liver cirrhosis, we compared the plasma glucose, insulin, and C-peptide levels during a frequently sampled i.v. glucose tolerance test (0.3 g glucose/kg BW) in nine compensated cirrhotic patients and nine healthy volunteers well matched for age, sex, and body weight. The insulin secretion rate was derived by the deconvolution of plasma C-peptide levels, insulin sensitivity was calculated using Bergman's minimal model method, and insulin clearance was estimated by dividing the 0-180 min area under the curve of insulin secretion rate by that of peripheral plasma insulin levels. The cirrhotic patients were characterized during the frequently sampled i.v. glucose tolerance test by a 60% greater insulin secretion rate (P < 0.05), a markedly reduced insulin sensitivity index (SI; 2.82 +/- 0.75 vs. 5.86 +/- 0.68 x 10(-4) min/mU.L; P < 0.01) and a 40% reduced insulin clearance (725 +/- 169 vs. 1165 +/- 99 mL/min.m-2; P < 0.05). The reduction of insulin clearance was significantly correlated with the amplitude of the portosystemic shunt, measured using an isotopic method (r = 0.75; P < 0.02). In conclusion, cirrhosis is characterized by an important peripheral hyperinsulinism, resulting from both a higher insulin secretion rate and a reduced insulin hepatic clearance; the severe insulin resistance explains the glucose metabolism alterations. [less ▲]

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See detailInteraction between the 67 kilodalton metastasis-associated laminin receptor and laminin.
Cioce, V.; Margulies, I. M.; Sobel, M. E. et al

in Kidney International (1993), 43(1), 30-7

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been ... [more ▼]

Normal and neoplastic cells interact with laminin via a variety of cell surface proteins. The specific binding sites on laminin for each particular cell surface laminin-binding protein have not yet been identified. In this study, the interaction between laminin and the high affinity metastasis-associated 67 kD laminin receptor (67 LR) was investigated by electron microscopy using the rotary shadowing technique. Laminin receptor that was purified from human colon carcinoma metastases appeared as a globular structure with a diameter of 5.2 +/- 0.8 nm. The 67 LR specifically bound to laminin on its long arm close to the intersection of the long and the short arms. There was no specific interaction of bovine serum albumin with laminin. Biochemical confirmation of the rotary shadowing experiments included slot blot solid phase assays in which [I125]-labeled 67 LR bound in a dose dependent manner to laminin as well as to the chymotrypsin resistant (C1) fragment of laminin that contains a short piece of the long arm. [I125]-labeled 67 LR did not bind to the pepsin resistant (P1) fragment of laminin that did not contain that segment on the long arm. This study therefore identifies the binding site on laminin for the 67 kD metastasis-associated laminin receptor as a region on the long arm of laminin close to the intersection of the four arms. [less ▲]

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See detailNo significant effect of an "atraumatic" needle on incidence of post-lumbar puncture headache or traumatic tap.
Lenaerts, M.; Pepin, J. L.; Tombu, S. et al

in Cephalalgia : An International Journal of Headache (1993), 13(4), 296-7

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients ... [more ▼]

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients punctured with Sprotte's "atraumatic" needle. No significant difference was found between the two groups in incidence of headache or in frequency of traumatic taps. [less ▲]

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See detailEffects of Proglumide and Enprostil on Omeprazole-Induced Fundic Endocrine Cell Hyperplasia in Rats
Delwaide, Jean ULg; Latour, Pascale ULg; Gast, Pierrette ULg et al

in Gastroentérologie Clinique et Biologique (1993), 17(11), 792-6

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and ... [more ▼]

Long-term treatment with omeprazole induces hyperplasia of enterochromaffin-like cells, closely related to hypergastrinemia. We studied whether proglumide, an antagonist of gastrin/CCK receptor, and enprostil, a synthetic prostaglandin E2 derivative, might inhibit this hyperplasia. Six groups of 8 rats were treated for 10 weeks: a) untreated controls; b) omeprazole 10 mumol/kg; c) proglumide 500 mg/kg; d) enprostil 30 micrograms/kg; e) association of omeprazole and proglumide; f) association of omeprazole and enprostil. Serum gastrin levels were measured at different times during treatment. After sacrifice, fundic argyrophil cells were assessed by Grimelius' staining. Serum gastrin levels and argyrophil cell density were not modified in proglumide- and enprostil-treated groups, as compared with controls. Omeprazole increased significantly these two parameters. When given with omeprazole, proglumide decreased significantly serum gastrin levels and argyrophil cell density, as compared to omeprazole alone, while enprostil did not modify significantly these two parameters. These results indicate that proglumide, but not enprostil, can counteract the omeprazole-induced argyrophil cell hyperplasia in rats. [less ▲]

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See detailRole of Neuropeptides in Acetylcholine-Induced Edema in Isolated and Perfused Rabbit Lungs
Delaunois, Annie ULg; Gustin, Pascal ULg; Ansay, Michel ULg

in Journal of Pharmacology and Experimental Therapeutics (The) (1993), 266(2), 483-491

Changes in pulmonary endothelial permeability and in microvascular hemodynamics in response to cumulative concentrations of acetylcholine (ACh) (10(-8) M to 10(-5) M) were investigated in isolated ... [more ▼]

Changes in pulmonary endothelial permeability and in microvascular hemodynamics in response to cumulative concentrations of acetylcholine (ACh) (10(-8) M to 10(-5) M) were investigated in isolated, perfused rabbit lungs. The total pressure gradient was partitioned into four components: arterial, pre- and postcapillary and venous. The capillary filtration coefficient (Kf, c) also was evaluated. ACh caused a significant increase in arterial and precapillary pressures at concentrations higher than 3 x 10(-6) M. The total pressure gradient and precapillary were significantly increased whereas arterial, postcapillary and venous pressure gradient remained unchanged. In papaverine (3 x 10(-4) M)-pretreated lungs, the vasoconstriction was abolished and a concentration-dependent increase in Kf,c was recorded from 10(-8) to 10(-5) M ACh. This reaction was accompanied by pulmonary edema. Atropine, indomethacin, aspirin, ketanserin, clonidine, morphine and (+/-)-CP 96-345, an antagonist of neurokinin NK1 receptors, completely prevented the effects of ACh on Kf,c. In contrast, cromolyn sodium and SR48968, a neurokinin NK2 antagonist, did not inhibit the response to ACh. Terfenadine together with cimetidine had a partially inhibitory effect. Changes in the Kf, c similar to those observed with ACh were induced by capsaicin (10(-4) M) by exogenous substance P (10(-7) M) and by 5-hydroxytryptamine (5-HT) (10(-4) M). The effects of SP were inhibited by aspirin, (+/-)-CP 96,345 and ketanserin, but not by atropine and antihistaminics. 5-HT effects were prevented by aspirin and not by (+/-)-CP 96,345. It was concluded that ACh-induced pulmonary edema was due to an increase in the capillary filtration coefficient.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailTransmission du virus BVD/MD et aspects épidémiologiques de l'infection
Boulanger, D.; Quatpers, D.; Mignon, Bernard ULg et al

in Bulletin des Groupements Techniques Vétérinaires (1993), 4

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See detailON THE FORMATION OF PHOTOSYSTEM-II CHLOROPHYLL PROTEINS AFTER A SHORT LIGHT FLASH IN ETIOLATED BARLEY LEAVES, AS MONITORED BY INVIVO FLUORESCENCE SPECTROSCOPY
Franck, Fabrice ULg

in Journal of Photochemistry and Photobiology B : Biology (1993), 18(1), 35-40

The biogenesis of photosystem II (PSII) was investigated using 77 K fluorescence spectroscopy in etiolated barley leaves subjected to a millisecond flash which reduced all protochlorophyllide (Pchlide ... [more ▼]

The biogenesis of photosystem II (PSII) was investigated using 77 K fluorescence spectroscopy in etiolated barley leaves subjected to a millisecond flash which reduced all protochlorophyllide (Pchlide) into chlorophyllide (Chlide). In darkness after the flash, a slow chlorophyll (Chl) band shift from 682 to 684 nm was associated with the development of PSII variable fluorescence. Two Chl fluorescence bands at 678 and 687 nm were formed during the shift, the 687 nm band corresponding to the spectrum of the PSII variable fluorescence. The development of PSII fluorescence was inhibited by chloramphenicol and enhanced by cyclobeximide, suggesting a competition between plastid- and nucleus-encoded proteins for Chl binding. [less ▲]

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See detailApport de la mesure ambulatoire de la pression artérielle dans une consultation d'hypertension artérielle
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in Journal de Cardiologie [= JDC] = Tijdschrift voor Cardiologie [= TVC] (1993), 5(1), 6-13

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 ... [more ▼]

La fréquence du syndrome de la blouse blanche, l'importance de la charge tensionnelle et de la variabilité de la pression artérielle au cours du nycthémère ont été analysées dans une population de 181 patients ayant bénéficié d'un enregistrement de la pression artérielle en ambulatoire pendant 24 heures. En dépit d'une bonne corrélation entre la mesure clinique de la pression artérielle et la pression moyenne de jour ou de 24 heures, on observe une discordance entre les niveaux de pression fournis par les deux méthodes (la pression clinique étant supérieure à la pression en ambulatoire et cela d'autant plus que la pression clinique est élevée). Lors de l'évaluation de l'efficacité du traitement antihypertenseur, l'analyse des tracés montre qu'un tiers des patients traités ont des pressions normalisées, alors que deux tiers d'entre eux conservent des pressions de jour et de 24 heures nettement supérieures aux critères définissant l'hypertension artérielle. Par ailleurs, cette étude souligne également la supériorité des valeurs de pression en ambulatoire (surtout la pression systolique) par rapport à la pression clinique comme prédicteur d'une hypertrophie ventriculaire gauche. Ces observations confirment l'intérêt de cette technique non invasive de mesure de la pression artérielle moyenne tant pour objectiver l'effet blouse blanche, et ainsi préciser le diagnostic d'une hypertension artérielle, que pour s'assurer du contrôle de la pression par les thérapeutiques antihypertensives. [less ▲]

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See detailEffects of Neurochemical Lesions of the Preoptic Area on Male Sexual Behavior in the Japanese Quail
Bailhache, T.; Surlemont, C.; Balthazart, Jacques ULg

in Brain Research Bulletin (1993), 32(3), 273-83

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of ... [more ▼]

Two experiments were carried out during which the noradrenergic neurotoxin, 5-amino-2,4-dihydroxy-alpha-methylphenylethylamine (5-ADMP) was applied to the brain of quail in order to evaluate the role of the noradrenergic system in the control of male copulatory behavior. In the first experiment, the ICV injection of 5-ADMP slightly enhanced the sexual behavior observed in testosterone (T)-treated castrated male quail. This brings additional support to the notion that norepinephrine tonically inhibits male copulatory behavior in quail. In the second experiment, 5-ADMP implanted directly into the preoptic area disrupted the restoration by T of copulatory behavior in castrated quail and, at the same time, produced a brain lesion that partly destroyed the sexually dimorphic medial preoptic nucleus, a previously established site of T action on behavior. These lesions produced by a high (presumably too high) concentration of neurotoxin provided an independent confirmation of effects previously observed after electrolytic lesions. Correlation analyses also confirmed that the medial part of the POM just rostral to the anterior commissure is more closely associated with copulatory behavior and may, therefore, represent a key center for steroid action on this behavior. [less ▲]

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See detailFundic Argyrophil Cell Hyperplasia in Atrophic Gastritis: A Search for a Sensitive Diagnostic Method
Belaiche, Jacques ULg; Delwaide, Jean ULg; Vivario, M. et al

in Acta Gastro-Enterologica Belgica (1993), 56(1, Jan-Feb), 11-7

Hypergastrinemia induces argyrophil cell hyperplasia in oxyntic mucosa (FACH) in patients with non-antral atrophic gastritis, with or without pernicious anemia. This proliferation favours the development ... [more ▼]

Hypergastrinemia induces argyrophil cell hyperplasia in oxyntic mucosa (FACH) in patients with non-antral atrophic gastritis, with or without pernicious anemia. This proliferation favours the development of carcinoid tumours. In order to determine the most usual appropriate method to document FACH, we have studied 29 consecutive fundic biopsies from 26 patients with fundic chronic gastritis. The study encompassed gastrinemia levels, standard histology permitting the classification of chronic gastritis, demonstration of FACH by Grimelius stain, immunohistochemical studies using NSE, chromogranin A and by electron microscopy. The FACH was classified for each stain as slight, moderate or severe. The study displayed a relationship between the grade of gastritis and the density of argyrophil endocrine cells in oxyntic mucosa assessed by Grimelius stain (p < 0.0001) and chromogranin A (P < 0.01). There was also a relationship between the serum gastrin level and the density of argyrophil endocrine cells detected by these two stains (p < 0.001). A highly significant correlation was observed between Grimelius stain and chromogranin A (p < 0.0001). On the other hand, no significant correlation was noted with either NSE or electron microscopy. We conclude that Grimelius stain and immunohistochemical studies against chromogranin A were the best methods for the demonstration of FACH in atrophic gastritis. One of these two techniques is sufficient in current practice for defining the patients at risk for subsequent surveillance. [less ▲]

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See detailOn the Use of Distance in the Taxonomic Study of Critical Plant Groups-Case Studies of Western European Orchidaceae
Tyteca, D.; Dufrêne, Marc ULg

in Annals of Botany (1993), 71(3), 257-277

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of ... [more ▼]

Four distance coefficients are compared on four data sets composed of samples coming from western European populations of the genera Dactylorhiza, Orchis and Epipactis (Orchidaceae). The performance of the distance coefficients is evaluated through: (a) the quality of clusters obtained by five classical methods (as compared to a priori classification), (b) the Mantel statistic with respect to an a priori distance matrix resulting from previous knowledge, (c) the result obtained with the k-means method, and (d) principal coordinate diagrams. It appears that: (a) the Mahalanobis distance based on the pooled dispersion matrix performs best on the whole; (b) a distance based on the recently developed Common Principal Component model, used with a log transformation, also provides useful information and performs best on the largest data set; (c) the Gölz and Reinhard taxonomic distance, widely used among orchidologists, is attractive for its simplicity, yet good performance and the valuable information it provides, despite its theoretical shortcomings. A brief taxonomic discussion is made on the results obtained for the Dactylorhiza samples, especially about samples whose identification was in doubt. [less ▲]

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See detailUltrastructure of CD57+ cells isolated from human tonsils or blood.
Bouzahzah, F.; Heinen, Ernst ULg; Antoine, Nadine ULg et al

in European Journal of Morphology (1993), 31(1-2), 82-6

The presence of CD4+, CD57+ T cells in the germinal centers has been reported by several authors. The CD57 antigen is also expressed by natural killer (NK) cells. We purified CD57+ cells from human ... [more ▼]

The presence of CD4+, CD57+ T cells in the germinal centers has been reported by several authors. The CD57 antigen is also expressed by natural killer (NK) cells. We purified CD57+ cells from human tonsils and blood by microdissection, rosetting with sheep red blood cells and magnetic cell sorting (MACS) and examined the ultrastructural morphology of these cells. Clear differences were found in cell aspect: blood NK contained large granules which were not found in the tonsillar CD57+ cells. These latter appeared medium-sized and not fully activated. After immunolabeling, the tonsillar CD57+ cells were mainly found in the light zone of the germinal centers. [less ▲]

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See detailStructure of triosephosphate isomerase from Escherichia coli determined at 2.6 A resolution
Noble, M. E.; Zeelen, J. P.; Wierenga, R. K. et al

in Acta Crystallographica Section D-Biological Crystallography (1993), 49(Pt 4), 403-17

The structure of triosephosphate isomerase (TIM) from the organism Escherichia coli has been determined at a resolution of 2.6 A. The structure was solved by the molecular replacement method, first at 2.8 ... [more ▼]

The structure of triosephosphate isomerase (TIM) from the organism Escherichia coli has been determined at a resolution of 2.6 A. The structure was solved by the molecular replacement method, first at 2.8 A resolution with a crystal grown by the technique of hanging-drop crystallization from a mother liquor containing the transition-state analogue 2-phosphoglycolate (2PG). As a search model in the molecular replacement calculations, the refined structure of TIM from Trypanosoma brucei, which has a sequence identity of 46% compared to the enzyme from E. coli, was used. An E. coli TIM crystal grown in the absence of 2PG, diffracting to 2.6 A resolution, was later obtained by application of the technique of macro-seeding using a seed crystal grown from a mother liquor without 2PG. The final 2.6 A model has a crystallographic R factor of 11.9%, and agrees well with standard stereochemical parameters. The structure of E. coli TIM suggests the importance of residues which favour helix initiation for the formation of the TIM fold. In addition, TIM from E. coli shows peculiarities in its dimer interface, and in the packing of core residues within the beta-barrel. [less ▲]

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See detailLong-Term Photometry of Variables at ESO. II. The Second Data Catalogue (1986-1990).
Sterken, C.; Manfroid, Jean ULg; Anton, K. et al

in European Southern Observatory Scientific Report (1993), 12

Not Available

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See detailLa myocardiopathie hypertrophique obstructive: options therapeutiques chirurgicales.
Radermecker, Marc ULg; SAKALIHASAN, Natzi ULg; Partoune, B. et al

in Revue Médicale de Liège (1993), 48(12), 659-65

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See detailNeutrophilic Eccrine Hidradenitis. A Case Report
Nikkels, Arjen ULg; Hansen, Isabelle ULg; Collignon, Jacques ULg et al

in Acta Clinica Belgica (1993), 48(6), 397-400

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old ... [more ▼]

Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis occurring most frequently during induction chemotherapy for a variety of malignancies. We report a case of NEH in a 41-year-old woman with acute myeloblastic leukemia under daunorubicin, cytarabine and etoposide chemotherapy. She developed red, tender and painful nodules on a shoulder. The lesions resolved spontaneously. Histological examination is mandatory as the clinical presentation of this dermatosis is highly polymorphic. Leukemia cutis, sepsis, deep fungal infection and Sweet's syndrome must be excluded as these implicate different therapies. [less ▲]

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See detailCloning of a human GHF-1/Pit-1 cDNA variant
Pernasetti, Flavia; Wera, Stefaan; Belayew, Alexandra et al

in Nucleic Acids Research (1993), 21(15), 3584

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See detailKonie pociagowe ardenskie
Burny, Philippe ULg; Lebailly, Philippe ULg; Ensch, D. et al

in Przeglad Hodowlany (1993), (3/1993), 21-22

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See detailExteroceptive suppression of temporalis muscle activity in patients with chronic headache and in normal volunteers: methodology, clinical and pathophysiological relevance.
Schoenen, Jean ULg

in Headache (1993), 33(1), 3-17

Exteroceptive suppression of temporalis muscle activity was studied in patients with chronic headache and in healthy controls. Among different methods of recording, averaging 10 full-wave rectified EMG ... [more ▼]

Exteroceptive suppression of temporalis muscle activity was studied in patients with chronic headache and in healthy controls. Among different methods of recording, averaging 10 full-wave rectified EMG responses produces results with acceptable variability and discomfort. The late temporalis exteroceptive suppression period (ES2) is reduced on average in patients with chronic tension-type headache; this finding has been reproduced by several independent laboratories. Mean duration of temporalis ES2 is also diminished, but to a lesser degree, in daily drug abuse headache and, as shown by others, in episodic tension-type headache. It is normal in migraine between attacks, cluster headache and various types of symptomatic headaches. Temporalis ES2 may be decreased in untreated patients with major depression. In healthy volunteers, temporalis ES2 duration is reduced by a short-lasting painful stimulus to peripheral limbs after a delay of 50 to 60 ms, and by a sub-motor threshold electromagnetic stimulation to the contralateral cerebral cortex after a delay of 20 to 30 ms. In contrast, long-lasting trains of peripheral painful stimuli have no effect. Various pharmacological agents are able to modify temporalis ES2. Its duration is increased by 5-HT antagonists, but decreased by 5-HT uptake blockers. Pharmacological effects may differ between controls and patients. Considering these results and available data on the anatomo-functional organization of masticatory reflexes, we postulate that temporalis ES2 is a marker of the excitability of interneuronal nets in the ponto-medullary reticular formation. In chronic tension-type headache, excitability of these interneurons is decreased because of inadequate control by the serotonergic raphe magnus nucleus and the periaqueductal gray matter. Dysfunctioning of the latter structures might be caused by abnormal limbic inputs to the brain stem. Some steps of this pathophysiological hypothesis can be verified by modern neurophysiological techniques. [less ▲]

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See detailSoluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia.
Beguin, Yves ULg; Lampertz, S.; De Groote, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(12), 2019-2025

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL ... [more ▼]

We measured the soluble (s) receptors CD23, CD8, CD4, interleukin-2 receptor (IL-2R, CD25), and transferrin receptor (TfR, CD71), in normal serum and in patients with chronic lymphocytic leukemia (CLL) and evaluated them in relation to clinical and biological parameters of the disease, as well as serum immunoglobulin E (IgE). Compared to 31 normal individuals, 42 CLL patients had increased levels of sCD23 (98.4 +/- 127.7 versus 0.9 +/- 0.3 U/ml, p < 0.001), sIL-2R (6080 +/- 7030 versus 1420 +/- 640 pg/ml, p < 0.001), sTfR (12,100 +/- 11,250 versus 5000 +/- 1050 ng/ml, p < 0.001), and sCD8 (510 +/- 191 versus 234 +/- 89 U/ml, p < 0.001), but normal sCD4 levels. Mean sCD23 levels remained normal in patients with non-Hodgkin's lymphoma (other than small lymphocytic), Hodgkin's disease, hairy cell leukemia, acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), multiple myeloma, or solid tumors. Advancing Rai clinical stage was associated with a progressive elevation of sCD23 (p < 0.001), while sCD8 (p < 0.05), sIL-2R (p < 0.001), and sTfR (p < 0.005) were highest in stage 2 patients. Discriminant analysis confirmed the value of soluble receptor determinations in the clinical evaluation of CLL patients. sCD23 correlated with sIL-2R (p < 0.001) and sTfR (p < 0.05) but not with sCD4 or sCD8, and displayed an inverse relationship with serum IgE (NS) and total gamma-globulin (p < 0.05). sIL-2R correlated with sCD23 (p < 0.001), sTfR (p < 0.001), sCD4 (p < 0.01), and sCD8 (p < 0.01). The lymphocyte count correlated with serum lactate dehydrogenase (LDH) (p < 0.05), sCD23 (p < 0.001) and sIL-2R (p < 0.01) but not sTfR, sCD8, or sCD4. Chemotherapy produced consistent reductions of sCD23 levels in two responding patients. We conclude that: (i) sCD23 is considerably elevated in CLL, correlates with the tumor mass and clinical stage, and could be helpful in monitoring these patients; and (ii) sIL-2R, sCD8, and sTfR levels are less specifically increased and could be influenced by other factors such as immune activation and erythropoiesis. [less ▲]

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See detailMuscles rotateurs d'épaule et isocinétisme
Croisier, Jean-Louis ULg; Mommer, R.; Crielaard, Jean-Michel ULg

in Médecine et Hygiène (1993), 51

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See detailSmall Bowel Enema and Diagnosis of Chronic Nonischemic Disturbance of Superior Mesenteric Venous Blood Flow
Boverie, J. H.; COUNET, D.; Meunier, Paul ULg et al

in Abdominal Imaging (1993), 18(3), 265-70

Chronic nonischemic disturbance of mesenteric venous blood flow is reported in 11 patients with a mean age of 19 years. This entity, rarely discussed in the literature, is different from acute thrombosis ... [more ▼]

Chronic nonischemic disturbance of mesenteric venous blood flow is reported in 11 patients with a mean age of 19 years. This entity, rarely discussed in the literature, is different from acute thrombosis and chronic thrombotic forms with portal hypertension or hypercoagulopathy. In eight patients this syndrome was secondary to organic lesions of different origin: mesenteric vein squeezed by fibrous bands or an abnormal jejunal artery (four cases), lymphoma involving the distal superior mesenteric veins (three cases), hemangioma causing microthrombi (one case). In three patients no etiology or predisposing factor was found. All patients presented with rectal hemorrhage. Small bowel enema showed a constant pattern in 11 patients: small nodules, modified by compression or peristalsis, involving the mesenteric border of the jejunoileal segment, and associated with thick, straight but regular folds. Mesenteric varices were suspected and led to angiographic studies which were normal in three cases, confirmed varices in eight cases, and thrombosis in four cases. Laparotomy was normal in three cases and established the etiological diagnosis in eight cases. Varices were shown in six cases. Arteriography and laparotomy were unable to reach a complete diagnosis. [less ▲]

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See detailL'évaluation des effets de LOGO : un bilan vingt ans après ...
Denis, Brigitte ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1993)

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See detailApplication de l'analyse fréquentielle à haute résolution
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Bulletin d'Audiophonologie (1993), IX(5), 490-497

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur ... [more ▼]

Nous avons appliqué l'analyseur fréquentielle à haute résolution à une population de voix chantée. Au travers de ce travail, deux éléments importants apparaissent:1. La confirmation du formant du chanteur dans le placement de la voix dans les résonateurs. Il s'observe plus particulièrement sur un fondamental grave et s'acquiert par technique et expérience. 2. L'observation du vibrato, qu'il convient d'avoir vu avant, son observation graphique pourrait être considérée comme pathologique. [less ▲]

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See detailDynamics of erythropoietic recovery following bone marrow transplantation: role of marrow proliferative capacity and erythropoietin production in autologous versus allogeneic transplants.
Beguin, Yves ULg; Oris, Renée ULg; Fillet, Georges ULg

in Bone Marrow Transplantation (1993), 11(4), 285-92

The mechanisms of erythrocyte recovery after BMT are not known. We investigated the respective role of marrow function and erythropoietin production in 31 ABMT and 47 allogeneic BMT by analysing ... [more ▼]

The mechanisms of erythrocyte recovery after BMT are not known. We investigated the respective role of marrow function and erythropoietin production in 31 ABMT and 47 allogeneic BMT by analysing peripheral counts, serum erythropoietin levels, and serum transferrin receptor (TfR) levels which have been shown to be a quantitative measurement of erythropoiesis. Median times to complete neutrophil (25 vs 48 days, p < 0.0001) and platelet (45 vs 263 days, p < 0.001) recovery were faster after allogeneic BMT than ABMT, but complete erythrocyte recovery was slower (218 vs 101 days, p < 0.001). After ABMT, erythrocyte recovery paralleled that of neutrophils and platelets, and erythropoietin levels remained appropriate for the degree of anemia. After allogeneic BMT, erythrocytes developed independently of the other cell lines and defective erythropoietin production delayed recovery of adequate erythropoietic activity. This correlated with an alteration of renal function only in those patients remaining erythropoietin deficient beyond day 180. However, supranormal erythropoietin levels in interstitial pneumonia suggests that erythropoietin response to hypoxia is not abrogated. CMV infection could also affect erythropoiesis through erythropoietin production after ABMT as well as allogeneic BMT. It is concluded that after ABMT the development of erythropoiesis is determined by the overall marrow proliferative activity and erythropoietin plays only a facilitating role. After allogeneic BMT, erythropoiesis depends on erythropoietin levels which remain inadequate for prolonged periods of time. The results suggest that the administration of recombinant human erythropoietin could reduce transfusion requirements after BMT. [less ▲]

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See detailSub-mesoscale Air-sea Interactions
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Journal of Marine Systems (1993), 4(2-3),

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See detailThe peripheral analgesic effects of opiods
Joris, Jean ULg; Hargreaves, Kenneth M

in APS Journal (1993), 2(1), 51-59

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See detailHigh Resolution Frequency Analysis as applied to the singing voice
Morsomme, Dominique ULg; Remacle, Marc; Millet, Benoite

in Folia Phoniatrica (1993), 45

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the ... [more ▼]

We have applied high-resolution vocal frequential analysis to a population of singing voices. Two important elements have become apparent: (1) Confirmation that the singing formant originates in the resonators. This is observed especially on a low fundamental, and it is acquired through technical skill and experience (2)Observation of the vibrato, which, isolated from the clinical study, regarding only its graphic presentation, could habe been interpreted as "abnormal". [less ▲]

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See detailAccelerated erythroid repopulation with no stem-cell competition effect in children treated with recombinant human erythropoietin after allogeneic bone marrow transplantation.
Locatelli, F.; Zecca, M.; Beguin, Yves ULg et al

in British Journal of Haematology (1993), 84(4), 752-4

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) to accelerate erythropoietic engraftment in paediatric patients undergoing allogeneic BMT. rHuEPO was administered ... [more ▼]

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) to accelerate erythropoietic engraftment in paediatric patients undergoing allogeneic BMT. rHuEPO was administered intravenously at a dose of 75 U/kg per day for 30 d after transplant. Erythroid repopulation, evaluated sequentially through the serum transferrin receptor, was faster in 15 patients receiving rHuEPO than in 16 historical controls (P = 0.0003). This faster erythroid engraftment resulted in a reduction in the total number of red blood cell units required to reach transfusion independence (2.7 +/- 1.2 v 4.2 +/- 2.3, P = 0.027). No significant difference in leucocyte or platelet regeneration was observed. These findings indicate that rHuEPO administration can accelerate erythroid recovery after allogeneic BMT and reduce red cell transfusion requirements with no stem-cell competition effect. [less ▲]

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See detailMourir à son postmoderne
Demoulin, Laurent ULg

in Ecritures (1993), 5

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à ... [more ▼]

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à distinguer du postmodernisme (si celui-ci existe). [less ▲]

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See detailOstéoporose postménopausique: le point sur la thérapeutique
Reginster, Jean-Yves ULg

in Medisearch (1993), 73

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See detailSynthetic model peptides for apolipoproteins. II. Characterization of the discoidal complexes generated between phospholipids and synthetic model peptides for apolipoproteins.
Corijn, J.; Deleys, R.; Labeur, C. et al

in Biochimica et Biophysica Acta (1993), 1170(1), 8-16

The structure, composition and physico-chemical properties of complexes generated between phospholipids and synthetic model peptides for the amphipathic helices of the plasma apolipoproteins were studied ... [more ▼]

The structure, composition and physico-chemical properties of complexes generated between phospholipids and synthetic model peptides for the amphipathic helices of the plasma apolipoproteins were studied. The sequences of the peptides were derived from that of the 18A peptide and designed to either enhance or decrease ionic interactions between pairs of peptides, as described in the accompanying paper. Complexes were prepared with dimyristoylphosphatidylcholine (DMPC), dipalmitoylphosphatidylcholine (DPPC), or with DPPC and cholesterol, and isolated on a Superose 6HR column. Association kinetics for the DMPC-peptides complexes were followed by measuring the turbidity as a function of the temperature. The diameters of the DPPC-peptide complexes, measured by gradient gel electrophoresis (GGE), were about 120 A. Fluorescence polarization measurements after labeling with diphenyl hexatriene (DPH) yielded transition temperatures of, respectively, 40.6, 41.5 and 41.8 degrees C for the DPPC/18AM1-, DPPC/18AM4- and DPPC/18A-peptide complexes. These values were confirmed by differential scanning calorimetry. Circular dichroism and infrared spectroscopy revealed that the peptides adopt an alpha-helical structure in solution and this percentage increased from 30-40% in the free peptides up to 50-60% in the complexes. Attenuated total reflection (ATR) infrared measurements of the complexes indicated that the peptides are oriented parallel to the acyl chains of the phospholipid bilayer. Denaturation of the peptides and of the peptide-lipid complexes was monitored by Trp fluorescence under addition of increasing amounts of GdmCl. The mid-points of the denaturation curves lie at, respectively, 0.05, 0.25 and 0.35 M GdmCl for the 18AM4, 18A and 18AM1 peptide and are shifted towards higher GdmCl concentrations after peptide-lipid binding. GdmCl denaturation decreased the alpha-helical content of the peptides and of the complexes, as monitored by circular dichroism measurement. The helix to random coil structure transition occurred at, respectively, 2.1, 2.2, and 2.0 M GdmCl for 18A, 18AM1 and 18AM4, compared to 5.1, 5.0, and 5.3 M in the corresponding complexes. These data suggest altogether that the structural properties, the mode of lipid-protein association and the stability of the phospholipid-peptide complexes are similar to those of native plasma apolipoproteins. The 18A and 18AM4 peptides which contain charged residues along the edge of the helix, leading to salt bridge formation between peptides were shown to mimic the amphipathic helices of the plasma apolipoproteins. [less ▲]

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See detailEffect of androgen treatmen on fear reactions in ewes
Vandenheede, Marc ULg; Bouissou, M. F.

in Hormones & Behavior (1993), 27

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See detailInventaire des végétaux éodévoniens de Belgique
Gerrienne, Philippe ULg

in Annales de la Société Géologique de Belgique (1993), 116

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See detailMathematical Programming Methods for Constrained Optimization: Dual Methods
Fleury, Claude ULg

in Progress in Astronautics and Aeronautics (1993), 150

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See detailMicroencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase
Nihant, Nicole; Stassen, S; Grandfils, Christian ULg et al

in polymer International (1993), 32

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This ... [more ▼]

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium. [less ▲]

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See detailPhysiologie de la cellule enterochromaffin-like (ECL) dans la régulation de la sécrétion gastrique acide
Delwaide, Jean ULg; Belaiche, Jacques ULg; Latour, Pascale ULg

in Médecine & Chirurgie Digestives (1993), 22

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir ... [more ▼]

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir quelle était la cellule fundique qui produisait de l'histamine dans les conditions physiologiques. Deux cellules seront envisagées, les mastocytes et les cellules ECL qui sont des cellules endocrines exclusivement localisées dans le fundus. Quelques arguments seront développés, dont ceux provenant de notre expérience, permettant de penser que la cellule ECL contient de l'histamine. L'article se terminera par un essai d'intégration de la cellule ECL dans le schéma de la sécrétion gastrique acide en montrant son rôle essentiel potentiel. [less ▲]

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See detailCloning and overexpression of the triosephosphate isomerase genes from psychrophilic and thermophilic bacteria. Structural comparison of the predicted protein sequences
Rentier-Delrue, Françoise ULg; Mande, Shekhar C; Moyens, Sylvianne et al

in Journal of Molecular Biology (1993), 229(1), 85-93

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments ... [more ▼]

We focused on the temperature adaptation of triosephosphate isomerase (TIM; E.C. 5.3.1.1.) by comparing the structure of TIMs isolated from bacterial organisms living in either cold or hot environments. The TIM gene from psychrophilic bacteria Moraxella sp. TA137 was cloned and its nucleotide sequence determined. Its deduced amino acid sequence revealed 34% identity with the thermophilic bacteria Bacillus stearothermophilus TIM. Expression vectors were constructed and recombinant Moraxella TA137 and Bacillus stearothermophilus TIMs were overproduced and purified to homogeneity. Recombinant TIM inactivation constants (Ki), measured at various temperatures, compared to those of the mesophilic Escherichia coli recombinant TIM clearly show that Moraxella TA137 and B. stearothermophilus TIMs have respectively psychrophilic and thermophilic characteristics. To try to elucidate the structure-thermolability and structure-thermostability relationship, factors affecting the overall stability of these two TIMs were examined, based on the alignment with the mesophilic chicken TIM, the three-dimensional structure of which is already known. From this comparison, it appears that the adaptability of TIM to high temperature is favored by better stabilizing residues for the helix dipole as well as better helix-forming residues whereas the adaptability of TIM to low temperature seems to reside in the nature of helix-capping residues. [less ▲]

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See detailArt et nature
Duchesne, Jean-Patrick ULg

in Art&fact (1993), 12

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See detailExteroceptive suppression of temporalis muscle activity: methodological and physiological aspects.
Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1993), 13(1), 3-10

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods ... [more ▼]

In recent years studies of the suppression of EMG activity in temporalis muscle induced by stimulation in the trigeminal territory have opened new perspectives in headache research. The various methods that have been used in different laboratories are reviewed and some of the physiological modulations of temporalis exteroceptive suppression are described. Among different methods of recording, averaging 10 full-wave rectified EMG responses produces results with acceptable variability and discomfort. In order to obtain maximal responses the intensity of the stimulation should reach at least 20 mA. To avoid habituation of the second temporalis exteroceptive suppression period (ES2), the stimulation frequency has to be at 0.1 Hz or below. The level of voluntary contraction is not a critical variable as long as it reaches 50% of maximum. Some physiological variations of temporalis suppression are well documented. In females, ES2 is shorter during menstruation than at mid-cycle and correlated with the estradiol/progesterone ratio in plasma. Conditioning temporalis ES2 by a preceding peripheral stimulus markedly reduces its duration, which is partly reversible by naloxone. Various pharmacological agents are able to modify temporalis ES2: its duration is increased by 5-HT1 antagonists, but decreased by 5-HT uptake blockers; contradictory results have been obtained with acetylsalicylic acid. These results suggest that inhibitory brain-stem interneurons mediating temporalis ES2 are inhibited by serotonergic afferents, probably from the raphe magnus nucleus, and that the latter receives an excitatory input from the periaqueductal gray matter and other limbic structures, in part via opioid receptors. [less ▲]

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See detailLocalisation scintigraphique de tumeurs neuroendocrines et de leurs métastases par un analogue de la somatostatine: [111In-DTPA-d-phe1] octréotide.
Beckers, Albert ULg; Pham, V. T.; Abs, R. et al

in Revue Médicale de Liège (1993), 48(6), 326-34

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See detailLe récepteur NMDA : base moléculaire du mécanisme d’action de la kétamine
Hanon, E.; Gustin, Pascal ULg; Ansay, M.

in Annales de Médecine Vétérinaire (1993), 137

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See detailA method of comparison of two close batches data: Application to analysis of fog formation causes
Boreux, Jean-Jacques ULg; Guiot, Joël

in Geophysical Research Letters (1993), 20(12), 1179-1182

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs ... [more ▼]

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs become particularly dense near certain industrial plants because of high concentration of hygroscopic combustion particles in the air. Their role in dense fog formation is estimated by comparing the local climates and CCN concentrations at two similar sites, the first being more subject to air pollution and dense fogs than the second. Orthogonal regression is applied to three meteorological variables (air temperature, relative humidity, wind speed) and CCN concentration. As we compare very close variables, bootstrap provides precise confidence intervals independent of Gaussian assumptions. Two sites are compared: they are located in the Meuse valley (Belgium) at a distance of about 15 km. We found that the local climate of the polluted site is not only colder and wetter but also richer in CCN that the control site. These results suggest interactions of natural and anthropogenic causes in dense fog formation at industrial site. This method is useful in various domains of geophysics when correlated time series have to be compared. [less ▲]

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See detailEchographic Characterization of Carotid Plaques
VAN DAMME, Hendrik ULg; TROTTEUR, Geneviève ULg; Vivario, M. et al

in Acta Chirurgica Belgica (1993), 93(5), 233-8

The histology of the endarterectomy specimen was compared with the preoperative echopattern of 154 plaques. Thirty-four ultrasound images were of poor quality. The 120 adequate echographies revealed 22 ... [more ▼]

The histology of the endarterectomy specimen was compared with the preoperative echopattern of 154 plaques. Thirty-four ultrasound images were of poor quality. The 120 adequate echographies revealed 22 dense hyperechogenic homogeneous plaques, 28 soft hypoechogenic homogeneous plaques, 53 inhomogeneous plaques, and 13 mixed plaques. According to the surface, lesions were subdivided as smooth (n = 63) or irregular (n = 57). Echography recognized fibrous plaques (dense homogeneous hyperechogeneous lesions), with a specificity of 87% and a sensitivity of 56%. Recent intraplaque haemorrhage is echographically apparent as a hypoechogenic area in 88% of cases, what corresponds to a specificity of 79% and a sensitivity of 75%. Echography proved to be more accurate than angiography in determining the presence or absence of ulceration. The ability to characterize the pathology of carotid atheroma by duplex scan make the clinicopathologic correlation of carotid plaques of practical importance. [less ▲]

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See detailStrutture asindetiche nella poesia italiana delle origini, Firenze.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1993)

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See detailAdemhalingsfunktie als eventueel limiterende factor voor de gezondheid, de produktie en prestaties bij de dieren
Lekeux, Pierre ULg

in Vlaams Diergeneeskundig Tijdschrift (1993), 62

After a description of the varions links of the oxygen line and a definition of the notion «limiting factor», this paper describes why the pulmonary function can become a limiting factor in some domestic ... [more ▼]

After a description of the varions links of the oxygen line and a definition of the notion «limiting factor», this paper describes why the pulmonary function can become a limiting factor in some domestic animals which have been intensively selected for improved economic or athletic performances [less ▲]

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See detailProperties and primary structure of a cold-adapted lipase from an Antarctic bacterium
Arpigny, J. L.; Feller, Georges ULg; Gerday, Charles ULg

in Archives Internationales de Physiologie et de Biochimie (1993), 101

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See detailEvidence that insulin-like growth factor 2 (IGF2) is the dominant thymic peptide of the insulin superfamily
Geenen, Vincent ULg; Achour, Imane; Robert, Françoise et al

in Thymus (1993), 21(2), 115-127

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human ... [more ▼]

Central T-cell tolerance of neurondocrine functions has been proposed to be primarily induced by the thymic repertoire of neuroendocrine self antigens. The present study aimed at characterizing the human thymic insulin-related self antigen able to represent the pancreatic islet ß cell function in face of the developing T cells. Immunofluorescence studies were performed on human and rat thymic sections, as wess as on the rat IT-45R1 thymic epithelial cell line using several antibodies to epitopes of the insulin peptide family. These studies identify beyond any doubt that IGF2 is the dominant thymic peptide of the insulin family. The sequence of an insulin-derived autoantigen is proposed. This autoantigen is a nonamer and has a hydrophobic residue leucine at position 9. In human species, this autoantigen would primarily be tolerogenic for the pancreatic ß-cell endocrine function during fetal development. [less ▲]

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See detailTypes de circulation atmosphériques, advection des masses d'air et variations climatiques: Le cas des hivers doux et des hivers rudes récents en Belgique
Erpicum, Michel ULg; Mabille, Georges ULg; Alexandre, Jean ULg

in Publications de l'Association Internationale de Climatologie (1993), 6

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative ... [more ▼]

In Belgium, air masse advections -as it appears at 850 hPa level- are very important for the explanation of the surface air temperature of mild winters. Nevertheless in case of severe winters, radiative conditions observed at tropospheric lower level and horizontal motion of very thin air masses (below 850 hPa level) seem to be more important for the explanation of ground level temperature. [less ▲]

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See detailPlasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro
Delree, P.; Ribbens, Clio ULg; Martin, Didier ULg et al

in Brain Research Bulletin (1993), 30(3-4), 231-7

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo ... [more ▼]

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy. [less ▲]

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