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See detailL'évaluation des compétences terminales. Synthèse de l'atelier langues modernes.
Delcomminette, Bernadette; Simons, Germain ULg

in Puzzle (2000), (9), 30-33

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See detailObservations sous Cass., 11 février 2000
Boularbah, Hakim ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (2000)

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See detailZwitterionic (pyrrolidine-2,2-diyl)bisphosphonic acid at 100, 150 and 293K
Olive, Gilles ULg; Ellis, Dianne D; Siri, Didier et al

in Acta Crystallographica Section C-Crystal Structure Communications (2000), C56(6), 720-722

Structure of the zwitterionic pyrrolidine-2,2-diylbis(phosphonic acid) at 100, 150 and 293 K

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See detailLes xeno-oestrogènes et leur impact sur l’environnement
Meurens, F.; Delaunois, A.; Beckers, Jean-François ULg et al

in Annales de Médecine Vétérinaire (2000), 145

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See detail5-HT2A receptor polymorphism gene in Bipolar Patients and Harm Avoidance personality trait
Blairy, Sylvie ULg; Massat, I; Staner, L et al

in American Journal of Medical Genetics Part B-Neuropsychiatric Genetics (2000), 96(3), 360-364

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See detailRandomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group.
REGINSTER, Jean-Yves ULg; Minne, H. W.; Sorensen, O. H. et al

in Osteoporosis International (2000), 11(1), 83-91

The purpose of this randomized, double-masked, placebo-controlled study was to determine the efficacy and safety of risedronate in the prevention of vertebral fractures in postmenopausal women with ... [more ▼]

The purpose of this randomized, double-masked, placebo-controlled study was to determine the efficacy and safety of risedronate in the prevention of vertebral fractures in postmenopausal women with established osteoporosis. The study was conducted at 80 study centers in Europe and Australia. Postmenopausal women (n = 1226) with two or more prevalent vertebral fractures received risedronate 2.5 or 5 mg/day or placebo; all subjects also received elemental calcium 1000 mg/day, and up to 500 IU/day vitamin D if baseline levels were low. The study duration was 3 years; however, the 2.5 mg group was discontinued by protocol amendment after 2 years. Lateral spinal radiographs were taken annually for assessment of vertebral fractures, and bone mineral density was measured by dual-energy X-ray absorptiometry at 6-month intervals. Risedronate 5 mg reduced the risk of new vertebral fractures by 49% over 3 years compared with control (p<0.001). A significant reduction of 61% was seen within the first year (p = 0.001). The fracture reduction with risedronate 2.5 mg was similar to that in the 5 mg group over 2 years. The risk of nonvertebral fractures was reduced by 33% compared with control over 3 years (p = 0.06). Risedronate significantly increased bone mineral density at the spine and hip within 6 months. The adverse-event profile of risedronate, including gastrointestinal adverse events, was similar to that of control. Risedronate 5 mg provides effective and well-tolerated therapy for severe postmenopausal osteoporosis, reducing the incidence of vertebral fractures and improving bone density in women with established disease. [less ▲]

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See detailDu chêne au tonneau
Jourez, Benoît ULg; Quin, Jean-Philippe

in Courrier du Bois (2000), 129

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les ... [more ▼]

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les Celtes il y a plus de 2000 ans, certains développements technologiques sont venus aider les artisans dans leur travail quotidien. Parallèlement, le progrès des connaissances dans les sciences du bois, de la chimie et de la microbiologie nous ont appris à quel point l'élevage du vin en fûts de chêne reste une étape essentielle dans la maturation de ce liquide sacré. [less ▲]

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See detailPour une démarche de qualité dans la formation continuée des enseignants : rôle de l'évaluation
Giot, Bernadette ULg

in Point sur la Recherche en Education (Le) (2000), 21

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See detailcompte rendu de : K. Vössing, Schule und Bildung im Nordafrika der römischen Kaiserzeit
Rochette, Bruno ULg

in Revue Belge de Philologie et d'Histoire (2000), 78(1), 256-258

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See detailLaparascopic management of a unicornuate uterus with two cavitated, non-communicating rudimentary horns
NISOLLE, Michelle ULg; Donnez, Jacques

in Human Reproduction (2000), 15(8), 1873-4

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See detailLaser-induced transitions between triply excited hollow states
Madsen, L. B.; Schlagheck, Peter ULg; Lambropoulos, P.

in Physical Review. A (2000), 62(6), 062719

Using complex scaling and a correlated basis constructed in terms of B splines, we calculate the Li+ photoion yield in the presence of a laser-induced coupling between the triply excited 2s(2)2p(P-2(0 ... [more ▼]

Using complex scaling and a correlated basis constructed in terms of B splines, we calculate the Li+ photoion yield in the presence of a laser-induced coupling between the triply excited 2s(2)2p(P-2(0)) and 2s2p(2)(D-2(e)) resonances in lithium, the first of which is assumed to be excited by synchrotron radiation from the ground state. The laser coupling between the triply excited states is shown to lead to a significant and readily measurable modification of the line profile which provides a unique probe of the dipole strength between highly correlated triply excited states. We also present results for some higher-lying triply excited states of P-2(0) symmetry. [less ▲]

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See detailNeuroendocrine regulation of GnRH release in induced ovulators.
Bakker, Julie ULg; Baum, M. J.

in Frontiers in Neuroendocrinology (2000), 21(3), 220-62

GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic ... [more ▼]

GnRH is the key neuropeptide controlling reproductive function in all vertebrate species. Two different neuroendocrine mechanisms have evolved among female mammals to regulate the mediobasal hypothalamic (MBH) release of GnRH leading to the preovulatory secretion of LH by the anterior pituitary gland. In females of spontaneously ovulating species, including rats, mice, guinea pigs, sheep, monkeys, and women, ovarian steroids secreted by maturing ovarian follicles induce a pulsatile pattern of GnRH release in the median eminence that, in turn, stimulates a preovulatory LH surge. In females of induced ovulating species, including rabbits, ferrets, cats, and camels, the preovulatory release of GnRH, and the resultant preovulatory LH surge, is induced by the receipt of genital somatosensory stimuli during mating. Induced ovulators generally do not show "spontaneous" steroid-induced LH surges during their reproductive cycles, suggesting that the positive feedback actions of steroid hormones on GnRH release are reduced or absent in these species. By contrast, mating-induced preovulatory surges occasionally occur in some spontaneously ovulating species. Most research in the field of GnRH neurobiology has been performed using spontaneous ovulators including rat, guinea pig, sheep, and rhesus monkey. This review summarizes the literature concerning the neuroendocrine mechanisms controlling GnRH biosynthesis and release in females of several induced ovulating species, and whenever possible it contrasts the results with those obtained for spontaneously ovulating species. It also considers the adaptive, evolutionary benefits and disadvantages of each type of ovulatory control mechanism. In females of induced ovulating species estradiol acts in the brain to induce aspects of proceptive and receptive sexual behavior. The primary mechanism involved in the preovulatory release of GnRH among induced ovulators involves the activation of midbrain and brainstem noradrenergic neurons in response to genital-somatosensory signals generated by receipt of an intromission from a male during mating. These noradrenergic neurons project to the MBH and, when activated, promote the release of GnRH from nerve terminals in the median eminence. In contrast to spontaneous ovulators, there is little evidence that endogenous opioid peptides normally inhibit MBH GnRH release among induced ovulators. Instead, the neural signals that induce a preovulatory LH surge in these species seem to be primarily excitatory. A complete understanding of the neuroendocrine control of ovulation will only be achieved in the future by comparative studies of several animal model systems in which mating-induced as well as spontaneous, hormonally stimulated activation of GnRH neurons drives the preovulatory LH surge. [less ▲]

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See detailVariability of Doppler ultrasound measurements of hindlimb blood flow in conscious horses
Raisis, Anthea L; Young, L. E.; Meire, H. B. et al

in Equine Veterinary Journal (2000), 32(2), 125-132

Ultrasonography of the left and right femoral artery and vein was performed in 5 conscious horses. Velocity waveforms, recorded using low pulse repetition frequency, were used to calculate time-averaged ... [more ▼]

Ultrasonography of the left and right femoral artery and vein was performed in 5 conscious horses. Velocity waveforms, recorded using low pulse repetition frequency, were used to calculate time-averaged mean velocity (TAV), velocity of component a (TaVa), velocity of component b (TaVb) and volumetric flow. Waveform analysis included calculation of early diastolic deceleration slope (EDDS) and pulsatility index (PI) and subjective description of the waveform. Measurements were recorded at monthly intervals for 6 months. The repeated measurements were used to determine the within-horse variation. Horses were then anaesthetised with halothane and the same measurements recorded 60 min after induction. Differences between measurements recorded in conscious and anaesthetised horses were determined. Within-horse variability for diameters of femoral arteries and veins was small (CV<10%). Within variability for all other measurements was marked (CV>11%), with within-horse variability being the largest for femoral venous flow (CV>35%). Source of variability was measurement error and biological variation. Despite variability in conscious horses it was possible to detect changes in blood flow during anaesthesia. In the femoral arteries, volumetric flow was lower and EDDS and PI was higher in anaesthetised horses. In the femoral veins, volumetric flow was also lower in anaesthetised horses. Therefore Doppler ultrasound appears to be a useful technique for studying blood flow in conscious and anaesthetised horses [less ▲]

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See detailL'artériopathie des membres inférieurs chez la personne âgée
Petermans, Jean ULg; Zicot, M.

in Angéiologie (2000), 52(1), 13-17

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See detailFormation des enseignants et évaluation : L'évolution depuis 1995
Beckers, Jacqueline ULg

in TNTEE (Thematic Network for Teacher Education in Europe) (2000)

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See detailA 1H, 13C, 31P and 15N NMR study of (pyrrolidine-2,2-diyl)bisphosphonic acid, tetraalkyl(pyrrolidine-2,2-diyl)bisphosphonates and acyclic tetraethyl bisphosphonates
Olive, Gilles ULg; van Genderen, Marcel H P

in Magnetic Resonance in Chemistry [=MRC] (2000), 38(5), 379-381

A multinuclear magnetic resonance study (1H, 13C, 31P, 15N) was performed on a series of new cyclic pyrrolidine bisphosphonates and acyclic bisphosphonates. Values are reported and discussed for the ... [more ▼]

A multinuclear magnetic resonance study (1H, 13C, 31P, 15N) was performed on a series of new cyclic pyrrolidine bisphosphonates and acyclic bisphosphonates. Values are reported and discussed for the chemical shifts and coupling constants of the various nuclei. [less ▲]

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See detailElectrical conduction by interface states in semiconductor heterojunctions
El Yacoubi, Mohamed; Evrard, Roger ULg; Nguyen, Ngoc Duy ULg et al

in Semiconductor Science & Technology (2000), 15

Electrical conduction in semiconductor heterojunctions containing defect states in the interface region is studied. As the classical drift-diffusion mechanism cannot in any case explain electrical ... [more ▼]

Electrical conduction in semiconductor heterojunctions containing defect states in the interface region is studied. As the classical drift-diffusion mechanism cannot in any case explain electrical conduction in semiconductor heterojunctions, tunnelling involving interface states is often considered as a possible conduction path. A theoretical treatment is made where defect states in the interface region with a continuous energy distribution are included. Electrical conduction through this defect band then allows the transit of electrons from the conduction band of one semiconductor to the valence band of the second component. The analysis is initiated by electrical measurements on n-CdS/p-CdTe heterojunctions obtained by chemical vapour deposition of CdS on (111) oriented CdTe single crystals, for which current--voltage and capacitance--frequency results are shown. The theoretical analysis is based on the numerical resolution of Poisson's equation and the continuity equations of electrons, holes and defect states, where a current component corresponding to the defect band conduction is explicitly included. Comparison with the experimental curves shows that this formalism yields an efficient tool to model the conduction process through the interface region. It also allows us to determine critical values of the physical parameters when a particular step in the conduction mechanism becomes dominant. [less ▲]

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See detailRenal Artery Occlusion Following Blunt Abdominal Trauma
Elen, Philippe ULg; Ozlu, E.; SakalihasanN, Natzi ULg et al

in Acta Chirurgica Belgica (2000), 100(3, May-Jun), 107-10

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See detailInfluence du 'sense of coherence' dans l'adaptation aux conséquences aversives du traumatisme
François, G.; Brouette, Béatrice ULg; Etienne, Anne-Marie ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2000), V(1), 20-27

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See detailPierre Bourdieu: Die Regeln der Kunst : Genese und Struktur des literarischen Feldes
Viehöver, Vera ULg

in Philosophischer Literaturanzeiger (2000), 53(4), 344-349

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See detailReseña de Los caminos de Borges. La Kábala, los mitos y los símbolos, de Beatriz Borovich
Willson, Patricia ULg

in Variaciones Borges (2000), (9), 261-263

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See detailCore-polarization effects in the Cadmium Isoelectronic Sequence
Biémont, Emile ULg; Froese Fischer, C.; Godefroid, M. R. et al

in Physical Review. A (2000), 62

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See detailComparison of rectal and infrared ear temperatures in older hospital inpatients.
Smitz, Simon ULg; Giagoultsis, T; Dewé, Walthère ULg et al

in Journal of the American Geriatrics Society (2000), 48(1), 63-6

OBJECTIVES: To assess the agreement between infrared emission detection (IRED) ear and rectal temperatures and to determine the validity of IRED ear thermometry in detecting rectal fever. DESIGN ... [more ▼]

OBJECTIVES: To assess the agreement between infrared emission detection (IRED) ear and rectal temperatures and to determine the validity of IRED ear thermometry in detecting rectal fever. DESIGN: Prospective, convenience sample, unblinded study. SETTING: An acute geriatric unit (teaching hospital) and a multidisciplinary intensive care unit. PARTICIPANTS: The study included 45 inpatients (26 women and 19 men), aged 78.3+/-6.9 years, admitted over a 4-month period. Twelve of the patients were definitely infected. MEASUREMENTS: Sequential rectal (RT) and ear temperature (ET) measurements were performed using mercury-in-glass and IRED ear thermometers, respectively. IRED ear temperatures were measured at both ears (unadjusted mode), with the highest of six ear temperatures considered the true value. RESULTS: Mean RT (37.39 degrees C +/- 0.52 degrees C) was significantly (P<.001) higher than mean ET (36.89 degrees C +/-0.59 degrees C). A highly significant positive correlation was found between RT and ET (slope = 0.69; 95% CI, 0.52-0.86; P<.001; r = 0.78). The mean bias (mean of the differences) between RT and ET was 0.50 degrees C +/-0.37 degrees C (95% CI, 0.41 degrees C-0.59 degrees C), and the 95% limits of agreement -0.22 degrees C and 1.23 degrees C (95% CI, -0.38 degrees C to 1.39 degrees C). According to the standard criterion (RT > or =37.6 degrees C), 14 patients were febrile. Using an optimum IRED ear fever threshold (37.2 degrees C), the sensitivity and specificity of IRED ear thermometry for predicting rectal fever were 86% and 89%, respectively (positive predictive value, 80%; negative predictive value, 93%). CONCLUSIONS: The degree of agreement between rectal temperature and the highest of six IRED ear temperatures was acceptable. Using an optimal IRED ear fever threshold of 37.2 degrees C (99 degrees F), IRED ear thermometry had acceptable sensitivity and specificity for predicting rectal fever. [less ▲]

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See detailRecension: "Vade-Mecum de l'évaluation médico-légale"
Kohl, Benoît ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2000)

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See detailAspects physiologiques de la sécrétion laitière par la mamelle bovine
Dosogne, H; Arendt, J; Gabriel, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailL'écriture en actes.
Baye, Ariane ULg; Denooz, Régine; Vanhulle, Sabine

in Lettre de la DFLM (La) (2000), 26

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See detailLuxation traumatique du tendon du tibialis posterior.
Kakanou, A.; Liloku, R.; NCHIMI LONGANG, Alain ULg et al

in Acta Orthopaedica Belgica (2000), 66(5), 514-6

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical ... [more ▼]

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical treatment is easy and reportedly gives excellent results, but the diagnosis is difficult and absence of diagnosis may result in functional instability of the foot requiring more invasive surgical treatment. [less ▲]

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See detailIpsilateral motor responses to focal TMS in normal man and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; Delwaide, Paul ULg et al

in Clinical Neurophysiology (2000), 111(Suppl. 1), 11512-05

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See detailCrucial role of the amino-terminal tyrosine residue 42 and the carboxy-terminal PEST domain of IkappaBalpha in NF-kappaB activation by an oxidative stress
Schoonbroodt, Sonia; Ferreira, V.; Best-Belpomme, Martin et al

in Journal of Immunology (2000)

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See detailFracture prevention. New topic
Bruyère, Olivier ULg; Reginster, Jean-Yves ULg

in Clinical Evidence (2000), 4

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See detailExpression of receptors for insulin-like growth factor-I and transforming growth factor-beta in human follicles.
Qu, Jian Ping; GODIN, Pierre-Arnaud ULg; NISOLLE, Michelle ULg et al

in Molecular Human Reproduction (2000), 6(2), 137-45

The in-vitro growth of immature oocytes in early follicles from cryopreserved human ovarian tissues is a new concept in in-vitro fertilization programmes for the treatment of infertile and cancer patients ... [more ▼]

The in-vitro growth of immature oocytes in early follicles from cryopreserved human ovarian tissues is a new concept in in-vitro fertilization programmes for the treatment of infertile and cancer patients. To better understand the regulatory mechanism of follicular development, immunohistochemistry was used to study the expression of insulin-like growth factor (IGF) type I receptor (IGF-IR) and transforming growth factor-β (TGFβ) type I (TβR-I) and type II (TβR-II) receptors in fresh and frozen ovarian tissues from 14 women. Immunoreactivities for IGF-IR and TβR-I were present simultaneously in the oocytes of primordial, pre-antral and antral follicles. Staining for both IGF-IR and TβR-I was also observed in granulosa cells of primordial, pre-antral and antral follicles. IGF-IR and TβR-I also stained in thecal cells of pre-antral and antral follicles. Stromal cells in surrounding ovarian tissue expressed IGF-IR and TβR-I at various follicular stages. Unlike TβR-I, TβR-II was expressed only in the oocytes of primordial and primary follicles, and with weak staining intensity in thecal cells. No significant staining for TβR-II was found in oocytes and granulosa cells of antral follicles. There was no difference in staining patterns for IGF-IR, TβR-I and TβR-II between fresh and frozen ovarian tissues, indicating that cryopreservation might not significantly alter the immunoreactivities of these receptors in frozen ovarian tissue. The results suggest that IGF-I and TGFβ may participate in the regulation of follicular growth by binding to their receptors through an autocrine or paracrine mechanism. IGF-I and TGFβ may be useful in regulating the in-vitro or in-vivo maturation of oocytes not only in later follicles but also very early follicles, from cryopreserved ovarian tissues for clinical use in the future. [less ▲]

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See detailLes composantes d'un management efficace dans le cadre des organisations sportives
Cloes, Marc ULg

in Sport (2000), 172

L'objectif de cet article consiste à réaliser une synthèse des notions abordées par les auteurs du colloque "Initiatives en matière de management du sport" et de fournir un outil permettant aux ... [more ▼]

L'objectif de cet article consiste à réaliser une synthèse des notions abordées par les auteurs du colloque "Initiatives en matière de management du sport" et de fournir un outil permettant aux responsables d'organisatons sportives de s'engager dans une auto-analyse des structures dont ils ont la charge. Pour rappel, le management se définit comme l'action de gérer, de diriger, d'assurer le succès d'une organisation. [less ▲]

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See detailBackground for studies on the treatment of male osteoporosis: state of the art.
Kaufman, J M; Johnell, O; Abadie, Eric ULg et al

in Annals of the Rheumatic Diseases (2000), 59(10), 765-72

Male osteoporosis represents an important, although long underestimated, public health problem. Both in men and in women aging is accompanied by continuous bone loss and by an exponential increase in the ... [more ▼]

Male osteoporosis represents an important, although long underestimated, public health problem. Both in men and in women aging is accompanied by continuous bone loss and by an exponential increase in the incidence of osteoporotic fracture, with a female to male incidence ratio of about 2 to 3 to 1 in the elderly for hip and vertebral fractures. Morbidity after osteoporotic fractures appears to be more serious and mortality more common in men than in women. To date, no single treatment has been proved to be effective and safe in published prospective studies. The present report, based on a systematic search of the literature on male osteoporosis, summarises the state of the art on the clinical consequences of male osteoporosis and its risk factors, in relation to the present state of knowledge about female osteoporosis. This constitutes the background for the design of rational clinical development strategies for therapeutic interventions in male osteoporosis. From this review of the literature it is apparent that notwithstanding the existing sex differences in pathophysiology of osteoporosis and the difference in age-specific incidence of osteoporotic fractures, there are also important similarities between osteoporosis in women and men. The higher incidence of fracture in women than in men results from quantitative differences in risk factors rather than from different risk factors. Even though there are sex differences in bone geometry, incidence of fracture seems to be similar in men and women for a same absolute areal bone mineral density. However, the lack of data on the changes in fracture rates in men resulting from pharmacological intervention, leading to changes in bone mineral density or bone turnover, remains the main limitation for extrapolation of established treatment outcomes from women to men. [less ▲]

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See detailTropisetron in the prevention of postoperative nausea and vomiting.
Boogaerts, J G; Bardiau, Françoise ULg; Seidel, Laurence ULg et al

in Journal of Clinical Anesthesia (2000), 12(5), 402-8

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN ... [more ▼]

STUDY OBJECTIVES: To evaluate the efficacy of tropisetron, a selective 5-HT(3) receptor antagonist, in preventing nausea and vomiting in high-risk inpatients undergoing various surgical procedures. DESIGN: Prospective, open, nonrandomized, observational, interventional study. SETTING: Postanesthesia care unit, and surgical wards of the University Hospital Center, Charleroi. PATIENTS: A total of 1,132 elective surgical inpatients (>15 years of age) in two separate surveys. The first prospective survey covered all surgical adult inpatients (n = 671) after various surgical procedures over a 3-month period. A new 3-month survey was performed to assess the effectiveness of the preventive measure and included another 461 patients. INTERVENTIONS: Risk factors associated with nausea and vomiting were recorded in the first survey and used to establish an antiemetic policy. This consisted in the administration of tropisetron 2 mg intravenously after anesthesia induction, if two patient-related risk factors associated with high-risk surgery and general anesthesia were present. MEASUREMENTS AND MAIN RESULTS: Nausea frequency and intensity, assessed every 4 hours using a visual analog scale (VAS), frequency and times of vomiting episodes and the need for rescue medication were recorded for 72 hours postoperatively. Nausea was experienced by 18.8% and vomiting by 9.8% of the patients in the first survey (211 high risk-patients of 671). In the second survey, 137 patients of 461, considered at high-risk received prophylactic tropisetron. The proportion of patients having nausea decreased to 11.1% (p,178 0.01) and vomiting episodes to 2.8% (p < 0.001). Twenty-six of the tropisetron-treated patients (19%) suffered subsequent postoperative nausea and vomiting (PONV). Patient satisfaction with tropisetron was high. CONCLUSION: Prophylactic tropisetron can reduce the incidence of PONV in selected high-risk inpatients undergoing various types of surgical procedures. [less ▲]

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See detailA new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi.
Bompard-Gilles, C; Villeret, V; Davies, G J et al

in Structure (2000), 8(2), 153-62

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate ... [more ▼]

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate N-terminal amino acids with both D and L stereospecificity. The DmpA active form is an alphabeta heterodimer, which results from a putative autocatalytic cleavage of an inactive precursor polypeptide. RESULTS: The crystal structure of the enzyme has been determined to 1.82 A resolution using the multiple isomorphous replacement method. The heterodimer folds into a single domain organised as an alphabetabetaalpha sandwich in which two mixed beta sheets are flanked on both sides by two alpha helices. CONCLUSIONS: DmpA shows no similarity to other known aminopeptidases in either fold or catalytic mechanism, and thus represents the first example of a novel family of aminopeptidases. The protein fold of DmpA does, however, show structural homology to members of the N-terminal nucleophile (Ntn) hydrolase superfamily. DmpA presents functionally equivalent residues in the catalytic centre when compared with other Ntn hydrolases, and is therefore likely to use the same catalytic mechanism. In spite of this homology, the direction and connectivity of the secondary structure elements differ significantly from the consensus Ntn hydrolase topology. The DmpA structure thus characterises a new subfamily, but supports the common catalytic mechanism for these enzymes suggesting an evolutionary relationship. [less ▲]

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See detailL'altération des bords de la tourbière active du Misten par l'exploitation de la tourbe pourrait dater du début du 14ième siècle
Hindryckx, Marie-Noëlle ULg; Streel, Maurice ULg

in Documents de la Station scientifique des Hautes-Fagnes (2000), 30(4), 95-101

Une étude récente (1999) de la végétation, de la variation du niveau de la nappe aquifère et des caractéristiques de la tourbe sous-jacente, à la périphérie de la tourbière active du Misten permet d ... [more ▼]

Une étude récente (1999) de la végétation, de la variation du niveau de la nappe aquifère et des caractéristiques de la tourbe sous-jacente, à la périphérie de la tourbière active du Misten permet d'entrevoir l'époque la plus probable d'exploitation de la tourbe dans la région de cette tourbière. Un calcul de la vitesse d'accumulation récente de la tourbe à différentes zones à la périphérie de la partie active de la tourbière a été effectué par des sondages de tourbe rapprochés et analysés finement au niveau palynologique. On constate que la vitesse d'accumulation de la tourbe varie selon les profils distants de 10m les uns des autres et que celle-ci diminue au fur et à mesure que l'on se rapproche du bord actuel de la tourbière active. A l'aide d'une datation au carbone 14, nous pouvons avancer que la date de l'altération du bord sud-est de la tourbière active du Misten a dû commencer vers 1330 AD (1170 + 160), soit bien antérieurement au creusement du fossé d'Eupen (1774), mais aussi bien avant les premières exploitations de tourbe connues dans les fagnes de Sourbrodt. [less ▲]

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See detailSystematic study and stratigraphic correlation of the Grandispora complex in the Famennian of Northwest and Eastern Europe
Higgs, K.T.; Avkhimovitch, V.I.; Loboziak, S. et al

in Review of Palaeobotany and Palynology (2000), 112

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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailEffect of gonadal steroids on pituitary LH secretion and mediobasal hypothalamic GnRH mRNA in ferrets.
Bakker, Julie ULg; Baum, M. J.

in Journal of Reproduction and Fertility (2000), 119(2), 315-21

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the ... [more ▼]

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the present study was to determine whether this sex difference reflects a sexually dimorphic effect of gonadal steroids on mediobasal hypothalamic GnRH mRNA content of male and female ferrets killed 4 weeks after gonadectomy, either with or without steroid hormone replacement. This time interval exceeds the 6-10 days needed for increments in plasma LH concentrations to stabilize after gonadectomy of ferrets of both sexes. In situ hybridization using an (35)S-labelled oligoprobe complementary to the human GnRH coding region showed that the number of mediobasal hypothalamic neurones and the cellular content of GnRH mRNA did not differ significantly among groups of male and female ferrets that were either in breeding condition or that had been gonadectomized and treated with sex steroids or oil vehicle. These results indicate that gonadal hormones regulate mediobasal hypothalamic GnRH biosynthesis and release in both sexes via post-transcriptional events that may include GnRH mRNA translation or the conversion of pre-pro GnRH precursor into mature GnRH. [less ▲]

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See detailErgotamine in the acute treatment of migraine: a review and European consensus.
Tfelt-Hansen, P.; Saxena, P. R.; Dahlof, C. et al

in Brain : A Journal of Neurology (2000), 123 ( Pt 1)

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe ... [more ▼]

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe reviewed the pre-clinical and clinical data on ergotamine as it relates to the treatment of migraine. From this review, specific suggestions for the patient groups and appropriate use of ergotamine have been agreed. In essence, ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions. For most migraine sufferers requiring a specific anti-migraine treatment, a triptan is generally a better option from both an efficacy and side-effect perspective. [less ▲]

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See detailCharacterization Of The Lipid-Binding Properties And Lipoprotein Lipase Inhibition Of A Novel Apolipoprotein C-Iii Variant Ala23thr
Liu, Hq.; Labeur, C.; Xu, Cf. et al

in Journal of Lipid Research (2000), 41(11), 9201-12

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated ... [more ▼]

The physicochemical properties of recombinant wild type and three site-directed mutants of apolipoprotein C-III (apoC-III), designed by molecular modeling to alter specific amino acid residues implicated in lipid binding (L9T/T20L, F64A/W65A) or LPL inhibition (K21A), were compared. Relative lipid binding efficiencies to dimyristoylphosphatidylcholine (DMPC) were L9T/T20L > WT >K21A > F64A/W65A with an inverse correlation with size of the discoidal complexes formed. Physicochemical analysis (Trp fluorescence, circular dichroism, and GdnHCl denaturation) suggests that L9T/T20L forms tighter and more stable lipid complexes with phospholipids, while F64A/W65A associates less tightly. Lipid displacement properties were tested by gel-filtrating apoE:dipalmitoylphosphatidylcholine (DPPC) discoidal complexes mixed with the various apoC-III variants. All apoC-III proteins bound to the apoE:DPPC complexes; the amount of apoE displaced from the complex was dependent on the apoC-III lipid binding affinity. All apoC-III proteins inhibited LPL in the presence or absence of apoC-II, with F64A/W65A displaying the most inhibition, suggesting that apoC-III inhibition of LPL is independent of lipid binding and therefore of apoC-II displacement. Taken together. these data suggest that the hydrophobic residues F64 and W65 are crucial for the lipid binding properties of apoC-III and that redistribution of the N-terminal helix of apoC-III (L9T/T20L) enhances the stability of the lipid-bound protein, while LPL inhibition by apoC-III is likely to be due to protein:protein interactions. [less ▲]

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See detailEvaluation of EMIT tox benzodiazepine and barbiturate assays on the Vitalab Viva analyser and FPIA on the Abbott ADx analyser
Charlier, Corinne ULg; Plomteux, Guy ULg

in Clinical Chemistry & Laboratory Medicine (2000), 38(7), 615-618

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in ... [more ▼]

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in preliminary therapeutic drug monitoring or acute drug intoxication detection. Performance, as indicated by CVs, of the Emit® tox benzodiazepine and barbiturate assays and FPIA showed that both immunochemical techniques are precise and have good reproducibility. For within-run studies, results from benzodiazepine determinations showed maximum CV values of 1.91% for the Emit® method and 2.65% for FPIA; results from barbiturate determinations showed maximum CV values of 2.01% for the Emit® method and 1.89% for FPIA. For between-run studies, results from benzodiazepine determinations showed maximum CV values of 1.79% for the Emit® method and 1.12% for FPIA; results from barbiturate determinations showed maximum CV values of 2.09% for the Emit® method and 2.02% for FPIA. [less ▲]

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See detail2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties
Olive, Gilles ULg; Mercier, Anne; Le Moigne, François et al

in Free Radical Biology & Medicine (2000), 28(3), 403-408

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-Noxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and ... [more ▼]

The 2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-l-oxide (EMPO), an easily prepared pyrroline-Noxide has been tested as a free radical scavenger. Spin adducts of superoxide, hydroxyl radical, and other free radicals were characterized in phosphate buffer at pH 7.0 and 5.6. At pH 7 in phosphate buffer, the EMPO/O2 2• spin adduct was estimated to be about five times more persistent than its DMPO analogue. Furthermore, its decay does not produce the EMPO/HO• adduct. [less ▲]

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See detailRural Labor Flows in China
Florence, Eric ULg

in Revue Bibliographique de Sinologie = Review of Bibliography in Sinology (2000), Vol. XVIII

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See detailCongestion Control for Layered Multicast Transmission
El Khayat, Ibtissam; Leduc, Guy ULg

in Networking and Information Systems Journal (2000), 3(3-4), 559-573

Heterogeneity of receivers makes it hard to control congestion for multicast transmission. Using hierarchical layering of the information is one of the most elegant and efficient approach to tackle this ... [more ▼]

Heterogeneity of receivers makes it hard to control congestion for multicast transmission. Using hierarchical layering of the information is one of the most elegant and efficient approach to tackle this problem. The proposed algorithm is based on this principle and has three objectives: to fulfill intra-session fairness, i.e. between different receivers of the same session; to be fair towards TCP; to fulfill inter-session fairness, i.e. same throughputs (and not number of layers) to concurrent sessions. [less ▲]

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See detailMarkers of tumor invasion are major predictive factors for the long-term outcome of corticotroph microadenomas treated by transsphenoidal adenomectomy.
Vallette-Kasic, S.; Dufour, H.; Mugnier, M. et al

in European Journal of Endocrinology (2000), 143(6), 761-8

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN ... [more ▼]

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN: Prospective study of 53 corticotroph microadenomas treated by enlarged adenomectomy. Patients followed for at least 2 years were classified into two groups: those in long-term remission and uncured patients (immediate failures and recurrences). Pre-, per- and postoperative parameters were analyzed as predictors of the long-term outcome. METHODS: Baseline hormone assessments were performed preoperatively, 8 days after surgery and every 6-12 months thereafter. Pituitary magnetic resonance imaging (MRI) allowed analysis of possible tumor extension to adjacent structures. Apparent completeness of the surgical removal was determined, and fragments labeled either 'tumor' or 'surrounding pituitary tissue' were submitted to serial sectioning. RESULTS: Immediate control of hypercortisolism was achieved in 43/53 patients (81%). However, later recurrences were observed in five patients (9%). Preoperative MRI showed tumor extension into adjacent structures with good specificity (91%) for prediction of surgical failure. Evidence of local invasion at surgery was also significantly predictive of the long-term outcome. A corticotroph adenoma was found at histological examination in 96% of the patients, and 26% had irregular limits, a feature significantly correlated with a poor outcome. Immediate postoperative plasma cortisol did not allow discrimination between long-term remissions and recurrences. CONCLUSION: Surgical failure was best predicted by signs of tumor 'invasiveness' at MRI, confirmed by peroperative examination and histology. [less ▲]

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See detailLa maladie de Kashin-Beck et le milieu rural au Tibet: un problème agri-environnemental
Haubruge, Eric ULg; Chasseur, Camille; Mathieu, Françoise et al

in Cahiers Agricultures (2000), 9

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See detailWandeinfluss auf die Sedimentationsgeschwindigkeit von Kugeln
Henschke, M; Waheed, A; Pfennig, Andreas ULg

in Chemie Ingenieur Technik (2000), 72(11), 1376-1380

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See detailHipóteses estatísticas : revendo idéias sobre ortogonalidade e balanceamento em análise de varîancia
Iemma, Antonio Francisco; Claustriaux, Jean-Jacques ULg; Palm, Rodolphe ULg

in Multiciência (2000), 4(1), 62-82

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See detailICPC-2-E: the electronic version of ICPC-2. Differences from the printed version and the consequences.
Okkes, I.; Jamoulle, Marc ULg; Lamberts, H. et al

in Family practice (2000), 17(2), 101-7

BACKGROUND: In 1998, ICPC-2 was published as a book. In the process of translating the book, and preparing an electronic version of chapter 10 (the actual classification), ICPC-2 proved to contain many ... [more ▼]

BACKGROUND: In 1998, ICPC-2 was published as a book. In the process of translating the book, and preparing an electronic version of chapter 10 (the actual classification), ICPC-2 proved to contain many errors and inconsistencies. Particularly, major problems were identified in the conversion between ICPC-2 and ICD-10, which could lead to major errors when used in electronic patient records. OBJECTIVES: We prepared an electronic version of chapter 10 of ICPC-2, ICPC-2-E, with all necessary corrections, to be published on the Oxford University Press web site as a part of this article. METHODS: Errors and inconsistencies were redressed, including particularly those in the con-version structure with all consequences on the level of inclusion and exclusion criteria, through a process of careful checking. RESULTS AND CONCLUSION: ICPC-2-E, the electronic version of chapter 10 of ICPC-2, is specifically to be used in an electronic patient record and for research purposes. It is to be used together with the first nine chapters of ICPC-2, since the book is indispensable to make a correct use of ICPC. [less ▲]

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See detailMeasurements of hindlimb blood flow recorded using Doppler ultrasound during administration of vasoactive agents in halothane-anesthetized horses
Raisis, Anthea L; Young, Lesley E; Meire, Hylton B et al

in Veterinary Radiology & Ultrasound : The Official Journal of the American College of Veterinary Radiology & the International Veterinary Radiology Association (2000), 41(1), 64-72

The purpose of the study was to determine the ability of Doppler ultrasound to detect changes in femoral blood flow during pharmacologic manipulation of arterial blood pressure. Doppler ultrasonography ... [more ▼]

The purpose of the study was to determine the ability of Doppler ultrasound to detect changes in femoral blood flow during pharmacologic manipulation of arterial blood pressure. Doppler ultrasonography was performed in the femoral vessels of six halothane-anesthetized horses before and during administration of phenylephrine HCI and sodium nitroprusside. The time-averaged mean velocity and volumetric flow were calculated. The contour of the velocity waveform was assessed, and the early diastolic deceleration slope (EDDS) and pulsatility index (PI) were calculated. Administration of phenylephrine HCI resulted in increased mean aortic blood pressure (MABP) by 40% (29.3-53.0%). This caused significant decrease in cardiac output (26.8 to 13.5 l/min), femoral arterial velocity (left artery 7.20 to 4.00 cm/s; right artery 5.01 to 3.39 cm/s) and volumetric flow (left artery 556 to 221 ml/min; right artery 397 to 193 ml/min) in the femoral vessels and significant increase in systemic vascular resistance (163 to 433 dyn-s/cm5), EDDS (1a: 285 to 468: ra: 250 to 481) and PI (1a: 9.38 to 20.4; ra 17.1 to 29.1). Administration of sodium nitroprusside resulted in a decreased MABP of 27.2% (22.5-33%). This increased cardiac output (20.8 to 32.4 L/min), however, no significant changes were observed in femoral blood flow. Despite obvious changes in the waveform contour, no significant change occurred in EDDS or PI. These results suggest that Doppler ultrasound may be useful for measuring femoral blood flow in anesthetized horses. However, waveform analysis appears to be limited when multiple changes occur in central and peripheral haemodynamics. [less ▲]

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See detailFetal renal artery flow and renal echogenicity in the chronically hypoxic state.
Suranyi, Andrea; Streitman, Karoly; Pal, Attila et al

in Pediatric Nephrology : Journal of the International Pediatric Nephrology Association (2000), 14(5), 393-399

The object of this study was to investigate the fetal renal arterial blood flow in normal and hyperechogenic kidneys during the third trimester of gestation. The pregnancies screened were all chronically ... [more ▼]

The object of this study was to investigate the fetal renal arterial blood flow in normal and hyperechogenic kidneys during the third trimester of gestation. The pregnancies screened were all chronically hypoxic. Depending on the etiology of the intrauterine chronic hypoxia, the cases were divided into two study groups. Group I comprised 120 pregnant women with pregnancy-associated hypertension and/or proteinuria. Group II consisted of 87 pregnancies with intrauterine growth retardation. Both study groups included pregnant women from the third trimester. Hyperechogenic renal medullae were detected in 15 out of 120 cases with pregnancy-associated hypertension and/or proteinuria, and in 22 fetuses of the 87 pregnancies involving intrauterine growth retardation. Fetal renal hyperechogenicity appears to be an indicator of fetal arterial circulatory depression, correlated with pathological changes in the resistance index for the fetal renal arteries. The fetal renal arterial blood flow resistance index was significantly lower in hyperechogenic cases. This may also be an in utero indication of subsequent intrauterine and neonatal complications, such as cesarean section because of fetal distress (43%), treatment in a neonatal intensive care unit (51%) or increased perinatal mortality (5.4%, as compared with 0.8-1.0% in the normal population). Detailed ultrasound and Doppler examinations of renal parenchyma and arteries appear to be useful methods in the prenatal diagnosis of reduced renal perfusion and of intrauterine hypoxia to detect possible pathological fetal conditions in utero. [less ▲]

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See detailPost-stroke reorganization of hand motor area: a 1 year longitudinal study with focal transcranial magnetic stimulation.
DELVAUX, Valérie ULg; ALAGONA G.; DE PASQUA, Victor ULg et al

in Clinical Neurophysiology (2000), 111(Suppl. 1), 12517-06

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See detailSocial Feeding In Ladybird Beetles: Adaptive Significance And Mechanism
Hemptinne, Jl.; Gaudin, M.; Dixon, Afg. et al

in Chemoecology (2000), 10(3), 149-152

Young larvae of Adalia bipunctata search an area more intensively when exposed to the odour from other larvae feeding on aphids than when exposed only to the odour of aphids. In an olfactometer young ... [more ▼]

Young larvae of Adalia bipunctata search an area more intensively when exposed to the odour from other larvae feeding on aphids than when exposed only to the odour of aphids. In an olfactometer young larvae were significantly attracted either to the odour of crushed aphids or larvae feeding on aphids, but not to that of aphids, larvae, larvae plus aphids or larvae feeding on an artificial diet. That is, the change in searching behaviour appears in response to a volatile released by aphids when attacked. The odour released by crushed aphids is made up entirely of aphid alarm pheromone, b-farnesene. It is likely that the adaptive significance of this response is that it increases the ability of larvae to locate larvae that have already caught prey. By sharing the aphid kill of another larva it is likely that a first instar ladybird larva greatly increases its probability of surviving to the next instar. It is suggested that this social feeding is facilitated by egg clustering, which also may additionally account for why aphidophagous ladybirds lay their eggs in clusters. [less ▲]

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See detailL’internationalisation des entreprises de distribution. Quelques observations au départ du cas européen
Merenne-Schoumaker, Bernadette ULg

in Géographies. Bulletin de l'Association de Géographes Français (2000), (2000-1), 66-73

To understand the internationalization of retailing, we must understand the internationalization of its entreprises. With this aim in view, one first case is chosen - Europa - and the processus is learned ... [more ▼]

To understand the internationalization of retailing, we must understand the internationalization of its entreprises. With this aim in view, one first case is chosen - Europa - and the processus is learned through the main questions of geography : what where ? which evolution ? who ? how ? why and why there and not elsewhere ? The lead of territory in the strategies and the choices of the firms is clearly showed; this fact confirms the geographical relevance of the thema « Globalization of Retailing ». [less ▲]

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See detailComment j'explore ... un cancer broncho-pulmonaire par imagerie metabolique (TEP-18-FDG).
Bury, Thierry ULg; DUYSINX, Bernard ULg; CORHAY, Jean-Louis ULg et al

in Revue Médicale de Liège (2000), 55(3), 178-83

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that ... [more ▼]

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that is useful in the characterization of a pulmonary solitary nodule and in the mediastinal or extrathoracic staging of known lung cancer. Preliminary studies suggest that PET may also be able to assess the therapeutic response after surgery or radiation therapy. [less ▲]

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See detailConsequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?
Kutter, D.; Devaquet, P.; Vanderstocken, G. et al

in Acta Haematologica (2000), 104(1), 10-5

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency ... [more ▼]

A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated. [less ▲]

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See detailL'osteoporose involutive de la femme: strategie therapeutique. Un point de vue actualise du Belgian Bone Club.
Kaufman, J M; Body, J J; Boonen, S et al

in Revue Médicale de Liège (2000), 55(5), 443-8

Osteoporosis is now considered as a major public health issue and a serious threat for the quality of life of elderly women. Several new compounds are currently marketed for the prevention and treatment ... [more ▼]

Osteoporosis is now considered as a major public health issue and a serious threat for the quality of life of elderly women. Several new compounds are currently marketed for the prevention and treatment of involutional osteoporosis in women. Therefore, it is important to offer to the practitioners pragmatic solutions to be used for the rational management of this disorder. This article is the result of a national consensus offering practical guidelines for the management of osteoporotic patients, based on the current published data. [less ▲]

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See detailTubal versus uterine placentation: similar HLA-G expressing extravillous cytotrophoblast invasion but different maternal leukocyte recruitment
Proll, J.; Bensussan, A.; Goffin, Frédéric ULg et al

in Tissue Antigens (2000), 56(6), 479-491

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect ... [more ▼]

The nonclassical HLA-G class I gene is expressed by extravillous cytotrophoblast that invades decidua in uterine pregnancy, suggesting that it may contribute to the immunological mechanisms that protect the fetus against maternal alloimmune response and/or pathogen infections. We first addressed the question of whether HLA-G expression was dependent on maternal tissue environment by comparing uterine and ectopic tubal pregnancies. Using HLA-G-specific mAb on placental cryosections, we found by immunohistochemistry that all subtypes of extravillous cytotrophoblast similarly expressed HLA-G in pregnant tubes, demonstrating that its expression was independent of the site of implantation. We next compared by immunohistochemistry the phenotype of maternal leukocytes recruited in both pregnant tissues. In contrast to decidua, pregnant tubes were characterized firstly, by the lack of natural killer (NK) cells and of cells expressing CD94 receptor specific for HLA-E, secondly, by a prominent increase of CD8+ T cells, dendritic cells, and macrophages, the latter co-expressing the LIR1/ILT2 killer immunoglobulin-like receptor (KIR), and finally, by the presence of cells expressing LIR2/ILT4 KIR or BY55 NK receptors, known to bind to HLA-G. Such cell types may favor a unique innate defense in pregnant tubes. These observations also suggest that trophoblast HLA-G expression does not influence the recruitment of particular maternal leukocytes in pregnant tissues. [less ▲]

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See detailRe-entrant Peierls distortion in IV-VI compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Bichara, C. et al

in Physica B: Condensed Matter (2000), 276-278

At room temperature, the local structure of crystalline group V elements (As, Sb,middotmiddotmiddot) and their IV-VI isoelectronic compounds (GeSe,middotmiddotmiddot) is governed by a Peierls distortion ... [more ▼]

At room temperature, the local structure of crystalline group V elements (As, Sb,middotmiddotmiddot) and their IV-VI isoelectronic compounds (GeSe,middotmiddotmiddot) is governed by a Peierls distortion of the simple cubic or NaCl structure which is a symmetry breaking electronic instability. The morphology of the distortion is determined by the filling ratio of the p-band; for a half-filled p-band, the sixfold coordination becomes 3 (short, covalent) +3 (long, van der Waals). In general, at high temperature, the structure recovers its higher coordination number. Neutron diffraction experiments have been made in the liquid state at lambda=0.7 Aring. It is observed that the Peierls distortion is still present in the liquid for most IV-VI compounds. This behavior is observed and discussed for a series of Sn and Ge chalcogenides: SnS, SnSe, GeS, GeSe and GeTe and their temperature evolution is discussed. GeSe and GeTe show an interesting re-entrant phase behavior. The heaviest IV-VI compound SnTe does not show a distorted state. We demonstrate that the hardness of the repulsive potential is a key parameter in this mechanism [less ▲]

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See detailDes indicateurs européens de qualité de l'éducation : les langues étrangères : un premier exercice
Blondin, Christiane ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2000), (3-4), 161-169

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See detailCrystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.
Concha, N. O.; Janson, C. A.; Rowling, P. et al

in Biochemistry (2000), 39(15), 4288-98

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there ... [more ▼]

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there is a current lack of potent and selective inhibitors of metallo beta-lactamases. Reported here are the crystal structures of the native IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor, 2-[5-(1-tetrazolylmethyl)thien-3-yl]-N-[2-(mercaptomethyl)-4 -(phenylb utyrylglycine)]. The structures were determined by molecular replacement, and refined to 3.1 A (native) and 2.0 A (complex) resolution. Binding of the inhibitor in the active site induces a conformational change that results in closing of the flap and transforms the active site groove into a tunnel-shaped cavity enclosing 83% of the solvent accessible surface area of the inhibitor. The inhibitor binds in the active site through interactions with residues that are conserved among metallo beta-lactamases; the inhibitor's carboxylate group interacts with Lys161, and the main chain amide nitrogen of Asn167. In the "oxyanion hole", the amide carbonyl oxygen of the inhibitor interacts through a water molecule with the side chain of Asn167, the inhibitor's thiolate bridges the two Zn(II) ions in the active site displacing the bridging water, and the phenylbutyryl side chain binds in a hydrophobic pocket (S1) at the base of the flap. The flap is displaced 2.9 A compared to the unbound structure, allowing Trp28 to interact edge-to-face with the inhibitor's thiophene ring. The similarities between this inhibitor and the beta-lactam substrates suggest a mode of substrate binding and the role of the conserved residues in the active site. It appears that the metallo beta-lactamases bind their substrates by establishing a subset of binding interactions near the catalytic center with conserved characteristic chemical groups of the beta-lactam substrates. These interactions are complemented by additional nonspecific binding between the more variable groups in the substrates and the flexible flap. This unique mode of binding of the mercaptocarboxylate inhibitor in the enzyme active site provides a binding model for metallo beta-lactamase inhibition with utility for future drug design. [less ▲]

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See detailVapor-Liquid Equilibria in Quaternary Mixtures of Dimethyl Ether + n-Butane + Etha-nol + Water
Dahlhoff, Gerd; Pfennig, Andreas ULg; Hammer, Hartmut et al

in Journal of Chemical & Engineering Data (2000), 45(5), 887-892

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See detailMolecular diversity of Microcystis strains (Cyanophyceae, Chroococcales) based on 16S rDNA sequences
LEPERE, Claire ULg; Wilmotte, Annick ULg; Meyer, Barbara

in Systematics and Geography of Plants (2000), 70

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These ... [more ▼]

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These sequences appear very similar to each other and to those of 71 Microcystis strains from four continents available in the databases. This great genotypic homogeneity, as measured by 16S rDNA sequence similarity (334 characters), is contrasting with the conspicuous morphological differences observed for the studied strains. [less ▲]

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See detailOuverture
Maes-Jelinek, Hena ULg

in Journal of Caribbean Literatures (2000), 2(1/2/3), 6-16

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See detailAuditory steady-state response and bispectral index for assessing level of consciousness during propofol sedation and hypnosis.
Bonhomme, Vincent ULg; Plourde, Gilles; Meuret, Pascal et al

in Anesthesia and analgesia (2000), 91(6), 1398-403

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects ... [more ▼]

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects to obtain effect-site concentrations of 1, 2, 3, and 4 microg/mL. The ASSR and BIS index were recorded during baseline and at each concentration. The ASSR was evoked by monaural stimuli. Propofol caused a concentration-dependent decrease of the ASSR and BIS index values (r(2) = 0.76 and 0.93, respectively; P<0.0001). The prediction probability for loss of consciousness was 0.89, 0.96, and 0.94 for ASSR, BIS, and arterial blood concentration of propofol, respectively. In Experiment 2, we compared the effects of binaural versus monaural stimulus delivery on the ASSR in six subjects during awake baseline and propofol-induced unconsciousness. During baseline, the ASSR amplitude with binaural stimulation (0.47+/-0.13 microV, mean +/- SD) was significantly (P<0.002) larger than with monaural stimulation (0.35+/-0.11 microV). During unconsciousness, the amplitude was 0.09+/-0.09 microV with monaural and 0.06+/-0.04 microV with binaural stimulation (NS). The prediction probability for loss of consciousness was 0.97 (0.04 SE) for monaural and 1.00 (0.00 SE) for binaural delivery. We conclude that the ASSR and BIS index are attenuated in a concentration-dependent manner by propofol and provide a useful measure of its sedative and hypnotic effect. BIS was easier to use and slightly more sensitive. The ASSR should be recorded with binaural stimulation. The ASSR and BIS index are both useful for assessing the level of consciousness during sedation and hypnosis with propofol. However, the BIS index was simpler to use and provided a more sensitive measure of sedation. IMPLICATIONS: We have compared two methods for predicting whether the amount of propofol given to a human subject is sufficient to cause unconsciousness, defined as failure to respond to a simple verbal command. The two methods studied are the auditory steady-state response, which measures the electrical response of the brain to sound, and the bispectral index, which is a number derived from the electroencephalogram. The results showed that both methods are very good predictors of the level of consciousness; however, bispectral was easier to use. [less ▲]

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See detailAutour de Stavelot-Malmedy (VIIe-IXe siècles)
George, Philippe ULg

in Publications de la Section Historique de l'Institut Royal Grand-Ducal de Luxembourg (2000)

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See detailLaparoscopic myolysis.
Donnez, Jacques; Sqifflet, Jean; Polet, Roland et al

in Human Reproduction Update (2000), 6(6), 609-13

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms ... [more ▼]

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms and global uterine volume in order to avoid hysterectomy. In the late 1980s, myolysis was performed laparoscopically with the help of the neodynium: yttrium aluminium garnet (Nd:YAG) laser. Later, bipolar needles were developed as an alternative to the Nd:YAG laser. Diathermy and cryomyolysis were also proposed but series are small in the literature. Very recently, myoma interstitial thermo-therapy (MITT) was performed using the diode laser and a specific optical light diffuser that is designed to transmit laser light in all directions. Laparoscopic myolysis was proved to be effective in provoking myoma shrinkage, with a dramatic decrease in size and a marked devascularization of the myoma and this technique can be proposed as an alternative to myomectomy in selected patients: only those aged >40 years or those not desiring to bear any more children. [less ▲]

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See detailIdentification de cultivars de palmier dattier (Phoenix dactylifera L.) par l'amplification aléatoire d'ADN (RAPD)
Ben Abdallah, Abdallah; Stiti, Kadija; Du Jardin, Patrick ULg et al

in Cahiers Agricultures (2000), 9(2), 103-107

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See detailSurfactin and iturin A effects on Bacillus subtilis surface hydrophobicity.
Ahimou, F.; Jacques, Philippe ULg; Deleu, Magali ULg

in Enzyme & Microbial Technology (2000), 27(10), 749-754

The synthesis of extracellular molecules such as biosurfactants should have major consequences on bacterial adhesion. These molecules may be adsorbed on surfaces and modify their hydrophobicities. Certain ... [more ▼]

The synthesis of extracellular molecules such as biosurfactants should have major consequences on bacterial adhesion. These molecules may be adsorbed on surfaces and modify their hydrophobicities. Certain strains of Bacillus subtilis synthesize the lipopeptides, which exhibit antibiotic and surface active properties. In this study the high-performance liquid chromatography (HPLC) analysis of the culture supernatants of the seven B. subtilis strains, showed that the lipopeptide profile varied greatly according to the strain. Among the three lipopeptide types, only iturin A was produced by all B. subtilis strains. Bacterial hydrophobicity, evaluated by the water contact angle measurements and the hydrophobic interaction chromatography, varied according to the strain. Two strains (ATCC 15476 and ATCC 15811) showing extreme behaviors in term of hydrophobicity were selected to study surfactin and iturin A effects on bacterial hydrophobicity. The two lipopeptides modified the B. subtilis surface hydrophobicity. Their effects varied according to the bacterial surface hydrophobic character, the lipopeptide type and the concentration. Lipopeptide adsorption increased the hydrophobicity of the hydrophilic strain but decreased that of the hydrophobic. Comparison of lipopeptide effects on B. subtilis surface hydrophobicity showed that surfactin was more effective than iturin A for the two strains tested. [less ▲]

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See detailLa contamination de l'eau et des aliments par les virus pathogènes pour l'homme
Scipioni, Alexandra ULg; Daube, Georges ULg; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (2000), 144

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See detailDe Don Quichotte à Michel Siffre : explorations du temps psychologique
Richelle, Marc ULg

in Bulletin de la Classe des Lettres (2000), 6e série, tome XI(7-12), 467-490

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See detailCurrent and future trends in groundwater vulnerability assessment
Gogu, Radu; Dassargues, Alain ULg

in Environmental Geology (2000), 39(6), 549-559

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have ... [more ▼]

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have failed to reach a consensus concerning the definitions of and reference terms for groundwater vulnerability assessment. Therefore, a review of vulnerability assessment and mapping methods providing a new classification system is necessary. This is focused on techniques that use the overlay and index class methods. New research challenges in vulnerability assessment are identified, especially the need for developing dynamic links between numerical models and overlay and index methods. [less ▲]

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See detailDe la relation spatiale entre les personnages des groupes statuaires royaux en Égypte pharaonique
Laboury, Dimitri ULg

in Revue d'Egyptologie (2000), 51

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional ... [more ▼]

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional art such as statuary, considering the case of the royal statue groups [less ▲]

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See detailThickness effects on the pinning by columnar defects
Silhanek, Alejandro ULg; Guimpel, J.; Civale, L. et al

in Physica C: Superconductivity (2000), 341(Part 2), 1217-1218

We compare the angular dependence of the pinning of equivalent columnar defects in GdBa2Cu2O7 thin films and a thicker YBa2Cu3O7 single crystal. The tracks' related enhancement of the critical currents is ... [more ▼]

We compare the angular dependence of the pinning of equivalent columnar defects in GdBa2Cu2O7 thin films and a thicker YBa2Cu3O7 single crystal. The tracks' related enhancement of the critical currents is much smaller for the case of the thin films. We interpret this thickness dependence as resulting from a competition between the pinning of the correlated structures, related to total sample thickness, and surface boundary conditions, which force the vortices to depin from the columnar defects near the sample surface. [less ▲]

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See detailComparative Effects Of Deltamethrin And Neem Kernel Solution Treatments On Diamondback Moth And Cotesia Plutellae (Hym., Braconidae) Parasitoid Populations In The Cotonou Peri-Urban Area In Benin
Goudegnon, Ae.; Kirk, Aa.; Schiffers, Bruno ULg et al

in Journal of Applied Entomology-Zeitschrift Fur Angewandte Entomologie (2000), 124(3-4), 141-144

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See detailBeta-radiation for coronary in-stent restenosis
Latchem, D-R; Urban, P; Goy, JJ et al

in Catheterization and Cardiovascular Interventions (2000), 51(4), 422-429

To determine the feasibility and safety of an intracoronary beta-radiation device in preventing the recurrence of in-stent restenosis (ISR) after successful angioplasty, we studied 37 patients treated ... [more ▼]

To determine the feasibility and safety of an intracoronary beta-radiation device in preventing the recurrence of in-stent restenosis (ISR) after successful angioplasty, we studied 37 patients treated with beta-radiation (30-mm strontium-90 source) after angioplasty. The mean reference diameter was 2.9 ± 0.5 mm, and 62% of lesions were diffuse, including four total occlusions. Beta-radiation was successfully delivered in 36 of 37 (97%) cases. Over the course of 7.1 ± 4.5 mo follow-up, there were no myocardial infarctions and three deaths: one from preexisting malignancy, one from progressive cardiac failure, and one from sudden cardiac death. Target vessel revascularization (TVR) was performed in seven of 36 (19%) patients. Thirty patients underwent angiography at 6 mo; three (10%) experienced restenosis (diameter stenosis > 50%) at the target site, four (13%) had edge stenoses, and two (7%) had late (> 1 mo) thrombotic occlusions. Beta-radiation for ISR is associated with encouragingly low rates of target lesion restenosis and TVR. Further improvements are needed to solve the limitations of the edge effect and late occlusion. [less ▲]

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See detailDe l'archétype savant au stéréotype politique : figures médiatiques du leader ouvrier
Geuens, Geoffrey ULg

in Quaderni : la Revue de la Communication (2000), 40 ("Utopie I : la fabrique de l'utopie")(Hiver 1999-2000), 53-67

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See detailNotions de base de physiologie de l'effort
Art, Tatiana ULg; Amory, Hélène ULg; Lekeux, Pierre ULg

in Pratique Vétérinaire Equine (2000), 32

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic ... [more ▼]

In general, muscular exertion occurs when there is oxygenation of the energy substrates carbon hydrate and fatty acids. At the beginning of exercise and/or when there is extra exertion, anaerobic metabolism also participates in the synthesis of ATP, which is essential for muscular contraction. The organism's oxygen consumption is proportional to the intensity of the effort, except during anaerobic metabolism. The maximum quantity of substrates that can oxygenate the muscles per unit time depends on the enzymatic material available. When the total aerobic capacity is used, the oxygen consumption is said to be maximal. The oxygen consumed at cellular level is taken from the ambient air at the areas of pulmonary exchange and transported throughout the body by the cardiovascular system. It is therefore essential that there is sufficient functional ability to adapt to cardiovascular and respiratory changes in order to ensure adequate O2 and nutrient transport and evacuation of CO2 and heat. The two systems adapt with exercise and training [less ▲]

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See detailAffections cardiaques et intolérances à l'effort. 1-Les troubles du rythme.
Amory, Hélène ULg; Art, Tatiana ULg

in Pratique Vétérinaire Equine (2000), 32(Numéro Spécial), 71-78

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See detailHabituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack.
Judit, A.; Sandor, P. S.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2000), 20(8), 714-9

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked ... [more ▼]

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked cortical potentials (IDAP). Clinical observations of migraine prodromes and previously published electrophysiological studies suggest that cortical information processing may vary in close temporal relationship to the attack. We studied PR-VEP and IDAP just before (11 MO pts), during (23 MO, 3 MA), 1 day following (27 MO, 1 MA) and 2 days following (14 MO) a migraine attack. The results were compared with a large group of MO patients recorded at a distance of at least 3 days from an attack (n = 66 for IDAP; n = 39 for VEP). Patients recorded the day before the attack had on average an habituation of -13.6+/-20.5% (mean +/- SD) between the 5th and 1st block of 100 averaged VEP responses and a flat (0.38+/-1.06 microV/10 dB) amplitude-stimulus intensity function (ASF) slope of the auditory evoked cortical potential. Both values were significantly different from those obtained in the attack interval (P=0.003; P=0.020). During the attack, VEP habituation was less pronounced (-0.17+/-26.2%) and ASF slopes remained flat (0.32+/-1.44 microV/10 dB; P=0.002 compared to interval). During the 2 days following the attack, VEP habituation was replaced by potentiation (+0.09+/-29.1% the 1st day; 19.5+/-45.7% the 2nd day) and ASF slopes increased markedly (0.87+/-1.39 and 1.14+/-1.12 microV/10 dB). The normalization of evoked cortical responses just before and during the attack, might reflect an increase in the cortical preactivation level due to enhanced activity in raphe-cortical serotonergic pathways. [less ▲]

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See detailOne-Step Gem-Diphosphorylation of Amides and Lactams
Olive, Gilles ULg; Le Moigne, François; Mercier, Anne et al

in Synthetic Communications (2000), 30(4), 619-627

We report the extension of an easy one-step synthesis of amino gem-bisphosphonates through the reaction of amides and lactams with trialkykphosphites

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See detailMelanoma screening: results of the first one-day campaign in Belgium (‘Melanoma Monday’)
Vandaele, M.; Richert, Bertrand ULg; Van der Endt, J. M. et al

in Journal of the European Academy of Dermatology & Venereology (2000), 14

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a ... [more ▼]

Background: Although the incidence of melanoma is increasing and many informative campaigns have been organized. The general population is still little informed about this tumour. Aims: To organize a media campaign, with more relevant information and the opportunity for free skin inspections. Methods: A ‘Task Force’ organized a media campaign in April 1999 and convinced 65% of the Belgian dermatologists to give up 4 h of their time to do free skin examinations for skin cancer on Monday 26 April 1999; it was called ‘Melanoma Monday’. Results: A total 2767 patients were screened. We found 25 melanomas and suspected 59 basal cell carcinomas. In the following 4 weeks another 141 melanomas were found. These 166 melanomas found in one month represent 15 –20% of the total number of melanomas per year in Belgium. Summary: A media campaign with relevant information combined with screening opportunities can lead to the early detection of melanomas in a large number of patients and can continue to alert people at risk in the following weeks. [less ▲]

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See detailNanoindentation investigation of Ti/TiN multilayers films
Ben Daia, M.; Aubert, P.; Labdi, S. et al

in Journal of Applied Physics (2000), 87(11), 7753-7757

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period ... [more ▼]

The hardness of Ti/TiN nanolaminated films is investigated in this study. Monolithic Ti and TiN films and Ti/TiN multilayers were deposited on silicon substrates by radio-frequency sputtering. The period thickness of multilayers was decreased from 20 to 2.5 nm. Grazing x-ray reflectometry showed that the modulation of composition of Ti/TiN multilayers exists for all the period thickness considered. From nanoindentation measurements, we determined the hardness and Young's modulus of multilayers. Hardness increased with decreasing period thickness to go beyond the rule-of-mixture value for samples with period thickness of Lambda less than or equal to 5 nm. The maximum hardness, 1.6 times higher than the value obtained by the rule of mixture, is obtained for Lambda=2.5 nm. Our results are compared to a dislocation-based model previously introduced by Lehoczky. (C) 2000 American Institute of Physics. [S0021-8979(00)09411-1]. [less ▲]

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See detailAssessment of postoperative nausea using a visual analogue scale.
Boogaerts, J G; Vanacker, E; Seidel, Laurence ULg et al

in Acta Anaesthesiologica Scandinavica (2000), 44(4), 470-4

BACKGROUND: Assessment of postoperative nausea intensity is difficult because nausea is a subjective and unpleasant sensation. We propose using the Visual Analogue Scale (VAS) device to increase the ... [more ▼]

BACKGROUND: Assessment of postoperative nausea intensity is difficult because nausea is a subjective and unpleasant sensation. We propose using the Visual Analogue Scale (VAS) device to increase the efficiency and precision in the assessment of nausea. We carried out a pilot study on postoperative patients suffering from nausea to measure the degree of agreement between the VAS scores and those given on a 4-point verbal descriptive scale (VDS). METHODS: Postoperative nausea was evaluated by means of a classical VAS (0-10 cm) device and a 4-point VDS (0=no nausea, 1=mild, 2=moderate, 3=severe) in 128 surgical spontaneously complaining patients. Evaluation was repeated 45 min after rescue medication given if nausea was intractable, lasted more than 10 min or at the request of the patient. Ordinal logistic regression was used to measure the association between VAS and VDS and to determine cut-off points on the VAS. RESULTS: The VAS device was easily understood and used by patients. VAS scores decreased significantly from 5.5+/-2.3 to 1.4+/-1.8 after rescue medication (P=0.002). Application of ordinal logistic regression to pre- and post-medication data combined yielded an agreement of 86% between VAS and VDS and the cut-off points on the VAS were estimated as follows: 0-1 (no nausea), 1+/-4 (mild), 4+/-7 (moderate) and 7+/-10 (severe). CONCLUSION: The VAS method proved to be useful for assessing quantitative nausea intensity and for testing the efficacy of rescue medication. It was found that a cut-off value of 4 on the VAS may be considered as a critical threshold triggering anaesthesiologists or nurses to administer rescue medication. [less ▲]

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See detailWilson Harris Issue
Maes-Jelinek, Hena ULg

in Journal of Caribbean Literatures (2000), 2(1-2-3), 289

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See detailThe Legionella (Fluoribacter) gormanii metallo-beta-lactamase: a new member of the highly divergent lineage of molecular-subclass B3 beta-lactamases.
Boschi, L.; Mercuri, Paola ULg; Riccio, M. L. et al

in Antimicrobial agents and chemotherapy (2000), 44(6), 1538-43

A metallo-beta-lactamase determinant was cloned from a genomic library of Legionella (Fluoribacter) gormanii ATCC 33297(T) constructed in the plasmid vector pACYC184 and transformed into Escherichia coli ... [more ▼]

A metallo-beta-lactamase determinant was cloned from a genomic library of Legionella (Fluoribacter) gormanii ATCC 33297(T) constructed in the plasmid vector pACYC184 and transformed into Escherichia coli DH5alpha, by screening for clones showing a reduced susceptibility to imipenem. The product of the cloned determinant, named FEZ-1, contains a 30-kDa polypeptide and exhibits an isoelectric pH of 7.6. Sequencing revealed that FEZ-1 is a molecular-class B beta-lactamase which shares the closest structural similarity (29.7% of identical residues) with the L1 enzyme of Stenotrophomonas maltophilia, being a new member of the highly divergent subclass B3 lineage. All the residues that in L1 are known to be directly or indirectly involved in coordination of the zinc ions were found to be conserved also in FEZ-1, suggesting that the geometry of zinc coordination in the active site of the latter enzyme is identical to that of L1. Unlike L1, however, FEZ-1 appeared to be monomeric in gel permeation chromatography experiments and exhibited a distinctive substrate specificity with a marked preference for cephalosporins and meropenem. The properties of FEZ-1 overall resembled those of a beta-lactamase previously purified from the same strain of L. gormanii (T. Fujii, K. Sato, K. Miyata, M. Inoue, and S. Mitsuhashi, Antimicrob. Agents Chemother. 29:925-926, 1986) and are as yet unique among class B enzymes, reinforcing the notion that considerable functional heterogeneity can be encountered among members of this class. A system for overexpression of the bla(FEZ-1) gene in E. coli, based on the T7 phage promoter, was also developed. [less ▲]

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See detailLa libre circulation des personnes dans l'Union européenne (1er janvier - 31 décembre 1999)
Carlier, Jean-Yves ULg

in Journal de Droit Européen [=JDE] (2000)

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See detailLate Frasnian - Famennian climates based on palynomorph analyses and the question of the late Devonian glaciations.
Streel, Maurice ULg; Caputo, MV; Loboziak, S et al

in Earth-Science Reviews (2000), 52(1-3), 121-173

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See detailCompte rendu de : Verhoogt-Vleeming, The Two Faces of Graeco-Roman Egypt
Rochette, Bruno ULg

in Bibliotheca Orientalis (2000), 57(5/6), 606-609

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See detailAdaptation et validation française du Sexual Irrationality Questionnaire (SIQ) de McCormick et Jordan
Kempeneers, Philippe ULg; Louwette, Séverine ULg; Mormont, Christian ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2000), 5(3), 5-18

Mc Cormick and Jordan's Sexual Irrationality Questionnaire (SIQ), elaborated in 1986, has been adapted to the French language and tested on a sample of 165 subjects. The organisation of the sexual ... [more ▼]

Mc Cormick and Jordan's Sexual Irrationality Questionnaire (SIQ), elaborated in 1986, has been adapted to the French language and tested on a sample of 165 subjects. The organisation of the sexual rationality-irrationality dimension depends on the gender of the subjects. Among female subjects, it appears mostly as a one-factor variable. Its optimal measure is supplied by the SIQ-R-F scale, a reduced version of the SIQ presenting a better internal consistency. Among male subjects, it rather appears structured in several independent factors. Factor analysis thus allows to distinguish four different patterns of sexual irrationality. Among female subjects, the decisive impact of sexual irrationality lies in an inhibition of sexual interest. Among male subjects, the sexual communication seems to be a vulnerable area of first importance. The external validity test of the SIQ is not very probant. This surely underlines a probable problem in the choice of the criteria as well as the compexity of the relationship between irrational cognitions and clinical data. [less ▲]

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See detail14-3-3 testing in diagnosing Creutzfeldt-Jakob disease: a prospective study in 112 patients.
Lemstra, A. W.; van Meegen, M. T.; Vreyling, J. P. et al

in Neurology (2000), 55(4), 514-6

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on ... [more ▼]

OBJECTIVE: To study the sensitivity and specificity of 14-3-3 testing in a prospective series of patients suspected of having Creutzfeldt-Jakob disease (CJD). BACKGROUND: The 14-3-3 protein immunoassay on CSF has favorable test characteristics as a premortem diagnostic tool in CJD. However, the 14-3-3 protein is a normal cellular protein expressed in various tissues, and its presence in CSF reflects extensive destruction of brain tissue as in CJD, but also in ischemic stroke and meningoencephalitis. METHODS: 14-3-3 was tested in the CSF of a prospective series of 110 consecutive patients suspected of having CJD. RESULTS: The sensitivity was 97% and the specificity was 87% in this series. False-positive results were mainly caused by stroke and meningoencephalitis. CONCLUSION: The 14-3-3 protein is a highly sensitive and specific marker for CJD when used in the appropriate clinical context. [less ▲]

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See detailL'ouvrier, l'usine et le syndicalisme wallons. Involutions et enjeux (1960-2000). Le crépuscule des industrieux
Geerkens, Eric ULg

in Reflets et Perspectives de la Vie Economique (2000), (2-3), 254-255

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See detail“Cross-Cultural Dialogues with Greek Classics: Walcott’s The Odyssey and Soyinka’s The Bacchae of Euripides.”
Bada, Valérie ULg

in Ariel : A Review of International English Literature (2000)

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See detailBase Plate in Bending and Anchor Bolts in Tension
Wald, Frantisek; Jaspart, Jean-Pierre ULg; sokol, Z et al

in Journal of Constructional Steel Research (2000)

The paper describes behaviour of the base plate in bending and the anchor bolts in tension, which is the major component of the base plate connection. The analytical model predicts the component ... [more ▼]

The paper describes behaviour of the base plate in bending and the anchor bolts in tension, which is the major component of the base plate connection. The analytical model predicts the component characteristics — the resistance and the stiffness. It is described how the quality of the behaviour is guided by the contact between the base plate and the concrete surface. The presented analytical prediction model is verified on tests and FE simulation. [less ▲]

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See detailA clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine.
Boureau, F.; Kappos, L.; Schoenen, Jean ULg et al

in International Journal of Clinical Practice (2000), 54(5), 281-6

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray ... [more ▼]

A multinational, multicentre, randomised, double-blind, double-dummy, crossover study (368 patients treating two attacks) was conducted to compare the efficacy and tolerability of sumatriptan nasal spray (20 mg) with dihydroergotamine (DHE) nasal spray (1 mg plus optional 1 mg). At the primary efficacy time point of 60 minutes after dosing, significantly more patients obtained headache relief (change from moderate or severe to none or mild) after treatment with sumatriptan than with DHE (53% sumatriptan, 41% DHE, p < 0.001). Significantly more patients reported relief of nausea after sumatriptan than after DHE at 60 minutes (64% sumatriptan, 49% DHE, p = 0.006). A significant difference between the two treatments was first observed at 45 minutes with respect to both headache relief (38% sumatriptan, 31% DHE, p = 0.037) and relief of nausea (55% sumatriptan, 40% DHE, p = 0.014). There were no significant differences between the two treatments for other measures of efficacy. Both treatments were well tolerated, with only 10% of patients in each group reporting one or more adverse events. The most frequently reported adverse event after sumatriptan was a bad or bitter taste, which was reported by 5% of patients. After DHE, 4% of patients reported symptoms of the nasal cavity/sinuses and 3% reported nausea and/or vomiting as adverse events. It is concluded that sumatriptan nasal spray is superior to DHE nasal spray in the relief of pain and nausea associated with acute migraine headache. [less ▲]

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