Evaluation quantitative et qualitative de la collaboration des toitures en tôles minces

in Construction Métallique (1983), 2

A parametric analysis is conducted to determine the important factor that govern the effectiveness of the diaphragm action provided by the stressed skin design of the trapezoïdal steel sheets of the roof ... [more ▼]

A parametric analysis is conducted to determine the important factor that govern the effectiveness of the diaphragm action provided by the stressed skin design of the trapezoïdal steel sheets of the roof. The benefir provided by the strassed skin design is quantified. [less ▲]

More on the reflection nebula surrounding HD 87643 and the non-uniform atmosphere of the central star

in Astronomy and Astrophysics (1983), 117

Different equivalent widths and line displacements of Hbeta and Fe II are observed in spectra of two condensations located within the reflection nebula surrounding HD 87643: they indicate important ... [more ▼]

Different equivalent widths and line displacements of Hbeta and Fe II are observed in spectra of two condensations located within the reflection nebula surrounding HD 87643: they indicate important relative motions (Deltav â ¡ 150 km s[SUP]-1[/SUP]) between various parts of the nebulosity and demonstrate that the stellar atmosphere in which the lines are formed is not isotropic and/or not homogeneous. The spectrum of another reflection nebula situated in the vicinity of HD 87643 is also briefly described. [less ▲]

Determination of mass-loss rates from early-type stars on the basis of 'log(W1)-log(W1 0)' diagrams

in Astronomy and Astrophysics (1983), 127

Using realistic expressions for the velocity and opacity distributions in rapidly expanding atmospheres, the author presents numerical results for the first order moment W[SUB]1[/SUB] of a P Cygni line ... [more ▼]

Using realistic expressions for the velocity and opacity distributions in rapidly expanding atmospheres, the author presents numerical results for the first order moment W[SUB]1[/SUB] of a P Cygni line profile calculated as a function of the parameter W[SUB]1[/SUB][SUP]0[/SUP] â Mn(level), where Mrepresents the mass-loss rate and n(level) the average fractional abundance of the relevant ion. The calculations clearly show that the resulting "log(W[SUB]1[/SUB]) - log(W[SUB]1[/SUB][SUP]0[/SUP])" curves depend almost essentially on the opacity distribution and that for unsaturated P Cygni line profiles the relation W[SUB]1[/SUB] â Mn(level) holds irrespective of the both distributions. For W[SUB]1[/SUB] ⪠0.24, the line profiles become saturated and the first order moment W[SUB]1[/SUB] does not provide anymore accurate information on the mass-loss rate. This technique of mass-loss determination and that which consists in fitting observed line profiles with theoretical ones are compared. [less ▲]

Rural Struggles and their Ideological Effects

in International Journal of Regional and Urban Research (1983), 7(4), 559-575

Heart rate and spontaneous work-rest cycles during exposure to heat

in Ergonomics (1983), 26(12), 1173-85

Les activités commerciales dans les secteurs piétonniers : structure et évolution

in Analyse de l'Espace (1983), (2), 19-37

Comparison of the structure and the evolution of retailing in the pedestrian areas of ten French cities and a town in Belgium: Liege

Investigation of nitrogen balance in dairy cows and steers nourished by intragastric infusion. Effects of submaintenance energy input with or without protein.

in British Journal of Nutrition (1983), 50(1), 99-107

Two dairy cows were maintained by intragastric infusion of volatile fatty acids and casein. Except when fasting, the casein-nitrogen was held constant, while total gross energy supply was varied from zero ... [more ▼]

Two dairy cows were maintained by intragastric infusion of volatile fatty acids and casein. Except when fasting, the casein-nitrogen was held constant, while total gross energy supply was varied from zero during fasting to 650 kJ/kg body-weight (W)0 . 75. One cow was estimated to attain zero N balance at an energy intake of 255 kJ/kg W0 . 75 and the other at 307 kJ/kg W0 . 75, which was calculated to be substantially below the estimated energy required for zero energy balance. When the cows were later given an N-free infusion for a period preceding the trial, N balance occurred at 98 kJ/kg W0 . 75 for one cow and 115 kJ/kg W0 . 75 for the other. Four steers were similarly nourished by intragastric infusion and the energy nutrient increased from 0 at fasting to 450 kJ/kg W0 . 75. The protein was held constant at 1 g N/kg W0 . 75 except at fasting. The energy level at which N balance occurred was 154 (SE 38) kJ/kg W0 . 75 or approximately equal to the energy content of the protein. The practical implications of these findings are discussed. [less ▲]

Action of Patulin on Yeast

in Applied & Environmental Microbiology (1983), 45

The action of patulin on Saccharomyces cerevisiae was studied. At weak doses, the drug inhibited growth, but inhibition was transient. After 10 min, syntheses of rRNA, tRNA, and probably mRNA were blocked ... [more ▼]

The action of patulin on Saccharomyces cerevisiae was studied. At weak doses, the drug inhibited growth, but inhibition was transient. After 10 min, syntheses of rRNA, tRNA, and probably mRNA were blocked; this was shown by radioactive precursor incorporation assays and gel electrophoresis of RNAs. After recovery of growth, patulin disappeared from the medium. It seemed that this degradation resulted from the activity of an inducible enzymatic system. Induced cells resisted very high patulin concentrations. [less ▲]

Interest of 5-hydroxytryptophan (5-HTP) test as a neuroendocrine marker of endogenous depression

in Acta Psychiatrica Belgica (1983), 83

Les plantes emsiennes de Marchin (vallée du Hoyoux, Belgique

in Annales de la Société Géologique de Belgique (1983), 106

Le marquage à l'immunoperoxydase appliqué aux techniques d'observation des surfaces cellulaires à haute résolution

in Biology of the Cell (1983), 48

Myelination and myelinating cells in culture

in Bulletin de la Société Belge d'Ophtalmologie (1983), 208(PT 1), 57-62

Phencyclidine inhibition of the acetylcholine receptor: measurement of cation flux in a sympathetic neuronal cell line using 22Na+ and spectroscopic detection of Cs+.

in Archives of Biochemistry & Biophysics (1983), 225(2), 500-4

The site of action of phencyclidine, a powerful and increasingly abused drug, in sympathetic nerve cells has not previously been identified. Here it is demonstrated that phencyclidine is a powerful ... [more ▼]

The site of action of phencyclidine, a powerful and increasingly abused drug, in sympathetic nerve cells has not previously been identified. Here it is demonstrated that phencyclidine is a powerful, noncompetitive inhibitor of the nicotinic acetylcholine receptor in a sympathetic nerve cell line, PC-12. In the presence of 1 mM carbamoylcholine the rate of the receptor-controlled influx of 22Na+ is reduced by a factor of 2 by 0.7 microM phencyclidine. Increasing concentrations of carbamoylcholine cannot reverse the inhibitory effect of the drug. Both the transmission of electrical signals between nerve cells and the secretion of catecholamines in the PC-12 cell line depend on the receptor-controlled ion flux. Thus phencyclidine interferes with at least two specific, physiologically important functions of these nerve cells. A new spectroscopic method has been developed to measure cation flux in cells. It is shown that this method can replace measurements of tracer ion flux. [less ▲]

Précision de la mesure de hauteurs d'essences feuillues

in Bulletin des Recherches Agronomiques de Gembloux (1983), 18(1), 61-69

La présente étude a pour objet de déterminer la précision de mesures de hauteurs effectuées sur une essence feuillue telle que le hêtre (Fagus sylvatica L.). A partir de mesures réalisées au dendromètre ... [more ▼]

La présente étude a pour objet de déterminer la précision de mesures de hauteurs effectuées sur une essence feuillue telle que le hêtre (Fagus sylvatica L.). A partir de mesures réalisées au dendromètre BLUME-LEISS sur plus de 150 arbres situés dans des peuplements d'allure jardinée, les calculs ont montré que l'on pouvait s'attendre à des écarts individuels atteignant 10 % entre hauteurs estimées et hauteurs mesurées sur arbres abattus. En moyenne, la mesure au dendromètre donnerait lieu à une surestimation d'environ 1 %. Dans l'hypothèse d'une seule mesure effectuée sur un arbre donné, pour un degré de confiance de 95 %, l'intervalle de confiance de l'écart entra la hauteur mesurée au dendromètre et celle mesurée sur arbre abattu, représente en moyenne environ 9 % de la hauteur des arbres. [less ▲]

Effect of protein-supplemented fasting on the fuel-hormone response to prolonged exercise in obese subjects.

in International Journal of Obesity & Related Metabolic Disorders (1983), 7(4), 327-37

This study aimed at investigating the influence of protein-supplemented fasting (PSF) on the tolerance and the fuel-hormone response to endurance exercise in the severely obese subject. For this purpose ... [more ▼]

This study aimed at investigating the influence of protein-supplemented fasting (PSF) on the tolerance and the fuel-hormone response to endurance exercise in the severely obese subject. For this purpose, eight obese men (27 +/- 2 yr, 182 +/- 7 per cent of ideal body weight) exercised on a horizontal treadmill (4 km/h) during 3 h before and after 13 d of PSF (Alburone, 70 g protein/day). Because of the 8.9 +/- 0.7 kg weight loss and the corresponding lower energy cost, exercise oxygen consumption decreased from 1.6 +/- 0.1 (before PSF) to 1.4 +/- 0.1 l/min (after PSF). In contrast, mean exercise heart rate was identical (119 +/- 5/min) in both conditions, resulting in a lower oxygen pulse after PSF. The mean respiratory quotient measured during exercise was lower after PSF (0.72 +/- 0.01 vs 0.75 +/- 0.01 2 P less than 0.05), thus demonstrating a higher fat utilization. This was supported by a higher exercise-induced plasma free fatty acid (FFA) mobilization after PSF (delta plasma FFA: + 675 +/- 101 vs + 376 +/- 121 mumol/l, 2 P less than 0.05). This metabolic adaptation mainly results from two mechanisms: a significantly lower plasma IRI at rest and during exercise after PSF (5.7 +/- 0.8 vs 11.4 +/- 1.4 microunits/ml, 2 P less than 0.001); and a lower basal blood glucose (4.2 +/- 0.2 vs 4.6 +/- 0.1 mmol/l) and an earlier decrease of glucose (30th vs 90th min) during exercise after PSF, suggesting a relative depletion of the carbohydrates stores. The lipolytic hormones (glucagon, epinephrine, norepinephrine, cortisol, growth hormone) did not significantly increase during exercise after PSF when compared to exercise before PSF; thus, their role in the enhanced FFA mobilization appears less important. Only two of our eight subjects were unable to achieve the third hour of exercise after PSF; however, no major clinical events or electrocardiographical disturbances were observed in any of the eight subjects. In conclusion, moderate exercise can be tolerated at least for 2 h during PSF when appropriate fluid, mineral and vitamin therapy is given. Under these conditions it induces a preferential utilization of fat-derived substrates and selectively augments fat mobilization which favors weight loss. For these reasons, moderate exercise can be recommended under strict medical supervision as part of all weight reduction therapy. [less ▲]

In vivo and in vitro effect of acyclovir on pseudorabies virus, infectious bovine rhinotracheitis virus and pigeon herpesvirus.

in Annales de Recherches Vétérinaires = Annals of Veterinary Research (1983), 14(3), 239-45

The effect of various concentrations of acyclovir on the mean plaque size of pseudorabies virus (SHV), infectious bovine rhinotracheitis virus (IBR virus) and pigeon herpesvirus (PHV) has been studied ... [more ▼]

The effect of various concentrations of acyclovir on the mean plaque size of pseudorabies virus (SHV), infectious bovine rhinotracheitis virus (IBR virus) and pigeon herpesvirus (PHV) has been studied. Acyclovir significantly reduced the mean plaque size of SHV and PHV, whereas IBR virus was less affected and did only show a reduction of the mean plaque size at the highest concentration of acyclovir used (1000 microM). In vivo effect of acyclovir was tested using pigeons and budgerigars experimentally infected with PHV and rabbits experimentally infected with a very low dose of SHV. Intramuscular injections of acyclovir (100 mg/kg/day; three injections/day) did not prevent the appearance of clinical disease in infected pigeons nor did reduce the level of viral excretion. The same treatment applied, as for the pigeons, before infection protected most of the budgerigars as long as they were treated, but most of them died soon after the end of the treatment. Only one rabbit was protected by the treatment. SHV was recovered in the lung of only one of the treated animals, whereas it was isolated in the lungs of each control animal. [less ▲]

Système HLA et greffe de moelle osseuse

in Revue Médicale de Liège (1983), 38

Approche hormonale desz problèmes de fertilité chez les taureaux culards Blanc Bleu Belge

in Revue de l’Agriculture = Landbouwtijdschrift (1983), 36

Différenciation de souches du virus de la rhinotrachéite infectieuse bovine (Bovine herpesvirus 1) par l'analyse du DNA viral après digestion par l'endonucléase de restriction Eco R1

in Annales de Médecine Vétérinaire (1983), 127

Monitoring of thiamine and its phosphate esters during the purification of the tetrodotoxin receptor from Electrophorus electricus membranes.

in IRCS Medical Science (1983), 11

Alteration in the nucleosome and chromatin structures upon interaction with platinum coordination complexes

in Biochimica et Biophysica Acta-Gene Structure and Expression (1983), 739(3), 317-25

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and ... [more ▼]

The interaction of various platinum coordination complexes with nucleosomes and chromatin has been investigated by ultraviolet absorption spectrophotometry, circular and electric linear dichroism, and thermal denaturation, at low binding ratios (r < 0.1–0.2). The general trend of the changes in these physicochemical properties is similar to that observed for the DNA-platinum complexes, which indicates that the same binding sites are involved in the platinum interaction with DNA and with its nucleoprotein complex. The cis-bidentate ligands, cis-dichlorodiammine, diaminocyclohexane and ethylenediamine platinum(II), showed a distinct behavior, with a more important destabilization of the DNA structure in the nucleoprotein than the trans-bidentate ligand, trans-dichlorodiammine-Pt(II), and monodentate ligand, diethylenetriamine-Pt(II). The drastic decrease of the negative electric dichroism in the 260 nm absorption band of the bases, observed with the five ligands, indicates a profound alteration of the DNA arrangement in chromatin and nucleosomes, attributed to a condensation of its superhelical structure. Some differences with previous observations on DNA complexes with the same platinum compounds indicate the possible formation of protein-DNA crosslinks in chromatin and nucleosomes. These could have some importance for the biological effects. [less ▲]

L'eau dans le vallon des chantoirs (Remouchamps) : une leçon sur les collaborations nécessaires

in Hydrographica (1983), 1-2/1983

Etude sur l'excrétion et la réexcrétion spontanée de deux souches vaccinales du virus de la rhinotrachéite infectieuse bovine (Bovine herpesvirus 1) par des veaux sains maintenus en station de sélection

in Annales de Médecine Vétérinaire (1983), 127

Enquête sérologique sur l'infection par le virus de la mamillite herpétique bovine (Bovine herpesvirus 2, BHV 2) en Belgique

in Annales de Médecine Vétérinaire (1983), 127

Increased neurophysin I and II cerebrospinal fluid concentrations from bipolar versus unipolar depressed patients.

in Neuroendocrinology Letters (1983), 5

Utero-placental vascularization in retardation of intra-uterine fetal growth

in Archives d'Anatomie et de Cytologie Pathologiques (1983), 31(2), 105-10

Détermination d’isochrones en région liégeoise selon les moyens de transport individuels

in Bulletin de la Société Géographique de Liège (1983), 19

Les nouvelles coopératives en Wallonie

in Revue Nouvelle (1983), (4), 453-462

En Belgique comme dans la plupart des pays occidentaux, on assiste depuis une dizaine d'années à un étonnant renouveau coopératif. Pour présenter ce phénomène, nous reprenons ci-après deux de nos textes ... [more ▼]

En Belgique comme dans la plupart des pays occidentaux, on assiste depuis une dizaine d'années à un étonnant renouveau coopératif. Pour présenter ce phénomène, nous reprenons ci-après deux de nos textes publiés par ailleurs mais qui traduisent assez bien deux moments distincts de l'histoire encore courte mais dense des nouvelles coopératives dans notre pays: le premier, écrit il y a sept ans, se veut une approche systématique de la nouvelle coopération à un moment où celle-ci connaît un "effet de mode" et fait l'objet de débats passionnés; le second, plus récent, propose un bilan provisoire alors que se précisent les structurations du mouvement et les principaux défis à relever. [less ▲]

A transition state theory of non-adiabatic unimolecular reactions controlled by a conical intersection

in Journal of Chemical Physics (1983), 79

Déficit budgétaire et épargne nationale

in Cahiers Economiques de Bruxelles (1983), (97), 194-207

Pratique de l'alimentation parentérale

in Revue Médicale de Liège (1983), 38(3), 91-96

Les cellules Immobilisées. Techniques du Génie Biochimique

in Annales de Gembloux (1983), 89

Evaluation de l'évapotranspiration réelle d'une pessière. Comparaison avec l'évapotranspiration potentielle

in Bulletin de la Société Géographique de Liège (1983), 19

Discriminant analysis based on multivariate response curves: a descriptive approach to dynamic allocation.

in Statistics in Medicine (1983), 2(1), 95-106

We examine the problem of discriminating between two groups in the context of multivariate response curves observed over a specified time interval. We propose a descriptive solution for the case where one ... [more ▼]

We examine the problem of discriminating between two groups in the context of multivariate response curves observed over a specified time interval. We propose a descriptive solution for the case where one can determine the response curves by linear interpolation between successive observations. Unlike most previously reported methods that use only the current multivariate observation, our approach accounts for the history of the process. Moreover the method has the potential advantage of being applicable dynamically, as one observes the multivariate response curve. Finally, the method demonstrates simplicity and flexibility, two important features for successful, routine, clinical application. [less ▲]

Fl. ERMINI, "à grand'peine..."

in Journal des Poètes (1983), (4-5), 26

The Al/Mg abundance ratio in halo stars

in Astronomy and Astrophysics (1983), 127

The Al to Mg abundance ratio is redetermined in two extreme metal-poor stars, HD 19445 and HD 140283, on the basis of accurate spectral material. It is found that: (1) one of the two lines used for the Al ... [more ▼]

The Al to Mg abundance ratio is redetermined in two extreme metal-poor stars, HD 19445 and HD 140283, on the basis of accurate spectral material. It is found that: (1) one of the two lines used for the Al abundance determination is blended by CH lines; (2) no anomalous difference appears between the hotter and the cooler star, both showing an Al overdeficiency; (3) the observations are in fair agreement with predictions from the theory of explosive carbon burning. [less ▲]

Cocurrent downward gas-liquid flow in packed beds. Part 2 : Stochastic model of liquid flow

in International Chemical Engineering (1983), 23

Découverte récente de Nyctalus leisleri en Corse

in Mammalia (1983), 47(3), 425-426

Mazindol in the treatment of Parkinson's disease.

in Archives of Neurology (1983), 40(13), 788-90

Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage ... [more ▼]

Mazindol, a drug that blocks the reuptake of dopamine, was studied in the treatment of Parkinson's disease in both a pilot study (12 patients) and a controlled trial (11 patients). The patients had stage II or III disease, according to the classification of Hoehn and Yahr. Both studies showed that mazindol possessed anti-parkinsonian properties and that the improvement was statistically significant. The therapeutic effect was moderate, but could be of value for patients in the early stages of the disease. The drug was well tolerated; only two patients had side effects. [less ▲]

Comparaison des proteines sarcoplasmiques de deux poissons antarctiques, Channichthys rhinoceratus, dépourvu de pigments respiratoires, et Notothenia magellanica, de formule sanguine normale

in Bulletin de la Société Royale des Sciences de Liège (1983), 52

Immunohistochemical demonstration of laminin, the major glycoprotein of basement membranes, as an aid in the diagnosis of soft tissue tumors.

in American Journal of Clinical Pathology (1983), 79(3), 306-11

Forty-eight benign and malignant soft tissue tumors were investigated immunohistologically for the presence of laminin, a glycoprotein of basement membranes. The results showed intense laminin positivity ... [more ▼]

Forty-eight benign and malignant soft tissue tumors were investigated immunohistologically for the presence of laminin, a glycoprotein of basement membranes. The results showed intense laminin positivity in schwannomas and neurofibromas and less intense positivity in leiomyomas and leiomyosarcomas, whereas fibrous histiocytomas and fibrosarcomas generally were negative. It is suggested that immunohistochemical demonstration of laminin is a valuable aid in the differential diagnosis between tumors derived from fibroblasts and Schwann cells, and a potential aid in the differential diagnosis between tumors originating from fibroblasts and those from smooth muscle cells. In addition to the expression seen in the tumors, all vascular walls were positive for laminin. Therefore, demonstration of laminin also can be used to examine the vascular pattern of tumors. [less ▲]

The missing UV opacity and the colours of solar-type stars

in Astronomy and Astrophysics (1983), 122

A simple method is proposed to take into account the "missing UV opacity" in solar-type stars. It is shown that the mere inclusion of that UV opacity through a very simple formula is sufficient to bring ... [more ▼]

A simple method is proposed to take into account the "missing UV opacity" in solar-type stars. It is shown that the mere inclusion of that UV opacity through a very simple formula is sufficient to bring the theoretical colours in agreement with observed ones for stars of different metal abundances and belonging to the spectral range from mid-F to late-G. Synthetic colours computed in the Geneva and UBV systems reproduce the various observed relations satisfactorily. The relations based on these colours allow reliable estimates of effective temperatures, surface gravities and metal abundances of stars. In addition, solar colours are obtained and three more solar twin candidates are proposed. [less ▲]

La méthode de l'angle critique: une conception particulière de l'échantillonage appliqué aux inventaires forestiers.

in Annales de Gembloux (1983), 89(3), 183-200

Creatine kinase isoenzymes in severe head injury.

in Journal of Neurosurgery (1983), 58(5), 689-92

Brain-type creatine kinase (CK) isoenzyme (CK-BB) was found in the ventricular cerebrospinal fluid (CSF) and the serum in a series of 35 patients within 13 hours following severe head injury. There was a ... [more ▼]

Brain-type creatine kinase (CK) isoenzyme (CK-BB) was found in the ventricular cerebrospinal fluid (CSF) and the serum in a series of 35 patients within 13 hours following severe head injury. There was a good correlation between total CK and CK-BB activities in CSF only. The values found in the CSF appear to be a quantitative index of brain dysfunction at admission, and did not correlate with intracranial pressure activity. High levels of CK-BB in the CSF correlated with a poor outcome, and thus offer a reliable criterion for the assessment of the severity of head injury. [less ▲]

Emploi du polymère WSR 301 dans les essais en bassin de carènes

in Bulletin de l'ATMA (1983)

A. VAUCHEZ, La sainteté en Occident aux derniers siècles du Moyen Age

in Moyen Age (Le) (1983)

Maternal vascular lesions in pre-eclampsia and intrauterine growth retardation: light microscopy and immunofluorescence.

in Placenta (1983), 4

Placental bed biopsies were performed during caesarean section in a series of 137 patients. Analysis of the morphological findings confirms that vascular physiological changes were reduced in pre ... [more ▼]

Placental bed biopsies were performed during caesarean section in a series of 137 patients. Analysis of the morphological findings confirms that vascular physiological changes were reduced in pre-eclampsia and in normotensive intrauterine growth retardation. In pre-eclampsia, acute atherosis in the decidual segments of uteroplacental arteries was a prominent feature. Intimal thickenings of the myometrial segments of the uteromaternal arteries were also noted. Normotensive intrauterine growth retardation cases were characterized by intimal thickenings of the myometrial segments of the uteroplacental arteries. Immunofluorescent investigations have demonstrated that the deep vascular stenoses were not associated with immunoglobulin deposition while in distal arterial segments displaying acute atherosis a positive immunofluorescence for IgG and fibrin and, more irregularly, for C'3 and IgM could be noted. These findings lead us to suggest that an immunological mechanism may be involved in the pathogenesis of acute atherosis. [less ▲]

Perspectives nouvelles dans la polyarthrite rhumatoïde (P.R.)

in Revue Médicale Marseille (1983), 2(7), 135-139

Plus d'un siècle après la description approfondie qu'en a fait Charcot, la polyarthrite rhumatoïde (P.R.L maladie pourtant fr équente. garde une pathogénie obscure. Dès 1940, Waeler mettait en évidence le ... [more ▼]

Plus d'un siècle après la description approfondie qu'en a fait Charcot, la polyarthrite rhumatoïde (P.R.L maladie pourtant fr équente. garde une pathogénie obscure. Dès 1940, Waeler mettait en évidence le facteur rhumatoïde, point de départ d'un échaffaudaqe d'hypothèses tentant d'expliquer les désordres immunitaires rencontrés dans cette affection.Par les réactions de Waeler-Rose. ou de latex. on met en évidence, chez beaucoup de patients atteints de P.R.~ un facteur rhumatoïde constitué d'une IgM anti IgG. Ce facteur caractérise, comme on le sait, les P.R. séropositives. Ce facteur garde en clinique une grande importance puisque sa présence en grande quantité assombrit le pronostic par l'apparition plus fréquente de manifestations générales. Par des techniques plus fines (immunofluorescence indirecte notamment). on a en effet constaté que la plupart, si pas toutes les P.R.~ possèdent un facteur rhumatoïde IgG ou IgA anti IgG . Mais comme lïgM anti IgG, l'IgG anti IgG peut aussi se mettre en évidence chez des sujets normaux, surtout âgés. L'interaction facteur rhumatoïde-lgG intervient grandement, avec d'autres complexes immuns circulants, dans le développement de lésions de vascularite. Les nouvelles techniques telles qu'irradiation lymphoïde et aphérèse, visent donc certains points de la pathogénie évoquée dans la P.R. : enlèvement de facteurs solubles contribuant au processus morbide ou/et ablation des cellules impliquées dans la réponse immunitaire anormale. Mais ces méthodes ne sont pas dépourvues de risques, elles sont en outre fort onéreuses. Elles restent néanmoins des armes très efficaces dans des situations graves, dépassées pour la thérapeutique habituelle. Petit à petit, elles nous dévoilent aussi certains volets encore cachés de la P.R., maladie multifactorielle où un trouble immunitaire occupe une place privilégiée mais dont la ou les causes nous échappent encore. [less ▲]

Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.

in Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association (1983), 20

A proliferative glomerulonephritis was induced in rats preimmunised with rabbit IgG by injecting a sub-nephrotoxic dose of rabbit anti-rat GBM IgG. All the rats developed a severe proteinuria within 2-5 ... [more ▼]

A proliferative glomerulonephritis was induced in rats preimmunised with rabbit IgG by injecting a sub-nephrotoxic dose of rabbit anti-rat GBM IgG. All the rats developed a severe proteinuria within 2-5 days after the injection of anti-GBM IgG. At the same time, many mononuclear phagocytes infiltrated the glomeruli, the colloidal iron staining of the glomerular filtration barrier was altered, and the urinary excretion of laminin and of neutral proteinase strongly increased. However, the pattern and intensity of staining of different collagenous and non-collagenous BM glycoproteins were not modified, as shown by indirect immunofluorescence microscopy. The existence of a direct significant correlation between the proteinuria and the laminin urinary excretion, and between the latter and the urinary neutral proteinase activity suggests that lysosomal proteinase of mononuclear phagocytes may be involved in the damage of the GBM during the course of this experimental glomerulonephritis. [less ▲]

La myopathie postanesthésique équine (MPAE)

in Annales de Médecine Vétérinaire (1983), 127