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See detailBiochemical characterization of the Pseudomonas aeruginosa 101/1477 metallo-beta-lactamase IMP-1 produced by Escherichia coli.
Laraki, N.; Franceschini, N.; Rossolini, G. M. et al

in Antimicrobial agents and chemotherapy (1999), 43(4), 902-6

The blaIMP gene coding for the IMP-1 metallo-beta-lactamase produced by a Pseudomonas aeruginosa clinical isolate (isolate 101/1477) was overexpressed via a T7 expression system in Escherichia coli BL21 ... [more ▼]

The blaIMP gene coding for the IMP-1 metallo-beta-lactamase produced by a Pseudomonas aeruginosa clinical isolate (isolate 101/1477) was overexpressed via a T7 expression system in Escherichia coli BL21 (DE3), and its product was purified to homogeneity with a final yield of 35 mg/liter of culture. The structural and functional properties of the enzyme purified from E. coli were identical to those of the enzyme produced by P. aeruginosa. The IMP-1 metallo-beta-lactamase exhibits a broad-spectrum activity profile that includes activity against penicillins, cephalosporins, cephamycins, oxacephamycins, and carbapenems. Only monobactams escape its action. The enzyme activity was inhibited by metal chelators, of which 1,10-o-phenanthroline and dipicolinic acid were the most efficient. Two zinc-binding sites were found. The zinc content of the P. aeruginosa 101/1477 metallo-beta-lactamase was not pH dependent. [less ▲]

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See detailHypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.
Minet, E.; Mottet, Denis ULg; Michel, G. et al

in FEBS Letters (1999), 460(2), 251-6

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear ... [more ▼]

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1alpha fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts with the bHLH-PAS domain of HIF-1alpha. Moreover, Hsp90 is not co-translocated with HIF-1alpha into the nucleus. At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation. [less ▲]

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See detail"Le choix de la voie la plus onéreuse sanctionné par la condamnation aux dépens"
Moreau, Pierre ULg

in Journal des Juges de Paix = Tijdschrift van de Vrederechters (1999), (8, 9, 10), 345-348

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See detailEnquête sur le "pouvoir thérapeutique" des dauphins
Servais, Véronique ULg

in Recherches en Communication (1999), 12

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest ... [more ▼]

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest that the "therapeutic effect" of animals are very sensitive to the experimental setting designed to demonstrate them. They tend to disappear in very stricly controlled conditions. The study also shows that the hypothesis that talk about "therapeutic effect" of animals are formally analogous to the magical talks about dolphin's "power to heal". [less ▲]

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See detailNumerical simulations of seasonal and interannual variability of the Black Sea thermohaline circulation
Stanev, Emil; Beckers, Jean-Marie ULg

in Journal of Marine Systems (1999), 22(4), 241-267

The Black Sea general circulation is simulated by a primitive equation model with active free surface. The forcing is seasonally variable and is based on available climatic data. The model reproduces the ... [more ▼]

The Black Sea general circulation is simulated by a primitive equation model with active free surface. The forcing is seasonally variable and is based on available climatic data. The model reproduces the main features of the Black Sea circulation, including the river discharge effects on the mean sea level and the Bosphorus outflow. Model results show that the simulated sea surface elevation increases in spring over the whole sea, reaching a maximum in the Danube delta area. In the same region, a minimum is observed in winter. The amplitude of the seasonal oscillations (about 8-12 cm over the whole basin) is of the same order of magnitude as the maximum horizontal variations (about 15-18 cm between the coastal areas and the basin interior). This strong signal formed mostly by river discharges, along with the seasonal variability in the other forcing functions and the local dynamics creates a well-pronounced interannual variability. The performance of the model in simulating the seasonal and interannual variability is critically analyzed, with a special attention on the cold intermediate water formation and the circulation in the upper 150 m. The simulations demonstrate that the source of intermediate waters is on the shelf, and that the water mass in the core of cold intermediate layer changes with time as a response to the periodic forcing at sea surface. This type of variability is characterized by pronounced interannual changes, proving that important differences could exist between water mass structure in different years, even when using identical atmospheric forcings each year. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailInter-laboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers.
Thierens, H.; Vral, A.; de Ridder, L. et al

in International Journal of Radiation Biology (1999), 75(1), 23-34

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples ... [more ▼]

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples from six donors were irradiated in vitro with doses ranging from 0.1 to 2Gy 60Co gamma-rays. Compared were a conventional analysis for dicentrics, the conventional micronucleus (MN) assay, the centromere micronucleus assay using p82H and an alphaAllCen pancentromeric probe, and tricolour FISH with chromosome 2, 4 and 8 DNA probes for the scoring of translocations. RESULTS: Agreement in the number of MN between Giemsa-and propidium iodine fluorescence-stained preparations was obtained. The control samples showed higher centromere positivity for the MN after FISH with the p82H probe compared with the alphaAllCen probe. The MN results with both probes showed a slight but systematic increase in the number of centromere-positive MN with dose, indicating that radiation, although principally clastogenic, also has aneuploidogenic properties. The values of the genomic translocation frequency (FG) derived from the observed translocation frequencies were systematically higher than the dicentric yields. Comparing the sensitivity of the different methods with restriction of the scoring time to 1 day for biomonitoring purposes, the centromere micronucleus assay had the lowest dose detection limit (0.1 to 0.2 Gy). CONCLUSION: This study shows that at present only the centromere micronucleus assay can combine high sensitivity with a reasonable scoring time for the biomonitoring of relatively large populations. [less ▲]

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See detailIdentification of mechanisms involved in the acute airway toxicity induced by parathion.
Segura, P.; Chavez, J.; Montano, L. M. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1999), 360(6), 699-710

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and ... [more ▼]

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and functional approaches. A plethysmographic technique for unrestrained guinea pigs was used to analyze Pth-induced modifications of airway mechanics and responsiveness to acetylcholine (ACh: 0.1-3.2 mg/ml, 2-min inhalation each dose). The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to ACh (10(-8)-10(-3) M), histamine (10(-8)-10(-3) M) and substance P (10(-10)-10(-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). We found that: (1) In guinea pigs Pth (3.2-17 mg/kg i.p.) produced a dose-dependent increase in a lung resistance index (iRL), which was greatly reverted (approximately 50%) by salbutamol (2 mg/ml, 2-min inhalation, or 10 microg/kg i.p.). This salbutamol effect was transient (5-10 min), suggesting that this bronchodilator triggered additional obstructive mechanisms. (2) Pth increased the water content in lung parenchyma samples, but not in trachea or bronchi, and augmented the respiratory secretions measured through monosaccharide content in bronchoalveolar lavage. (3) The increase in iRL was greater in female animals, probably due to a higher P450 basal activity, and completely blocked by pharmacological inhibition of P450 with piperonyl butoxide (500 mg/kg i.p.). (4) In male guinea pigs a subclinical dose of Pth (10 mg/kg i.p.) induced airway hyperresponsiveness to ACh. In isolated perfused rabbit lung Pth (10(-6) M) produced airway hyperresponsiveness to ACh and histamine, the latter prevented by atropine (10(-5) M). (5) Repetitive exposure to subclinical doses (1 mg/kg s.c.) of Pth during 1 week caused approximately 80% inhibition of P450 activity in rabbits, which was not enough, however, to prevent the functional manifestation of Pth toxicity in the airways. [less ▲]

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See detailQuantitative palynology of Famennian events in the Ardenne-Rhine Regions.
Streel, Maurice ULg

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailFlow cytometry estimation of nuclear size and ploidy level of habituated calli of sugar beet
Kevers, Claire ULg; Greimers, Roland ULg; Franck, Thierry ULg et al

in Biologia Plantarum (1999), 42(3), 321-332

A fully habituated (auxin- and cytokinin-independent) self-regenerating (organogenic) sugar beet cell line (HO) and a fully habituated non-organogenic one (HNO) derived from the former one, were analyzed ... [more ▼]

A fully habituated (auxin- and cytokinin-independent) self-regenerating (organogenic) sugar beet cell line (HO) and a fully habituated non-organogenic one (HNO) derived from the former one, were analyzed as to their nuclear size and DNA content. Flow cytometry and image analysis were used and cells of certified diploid leaves of the same sugar beet strain served as controls. The HNO cells had been shown previously to have many characteristics of cancerous cells. The analyses made on leaves and HNO cells indicated the presence of only one population of cycling cells. In HO cells. two cycling populations were detected: the first one had the same DNA content as the leaves while the second one contained two fold more DNA than the first population. HNO cells showed the higher nuclear size and DNA content. HNO cells also showed evidence of aneuploidy. Thus, nuclear size, DNA content and ploidy level increase together with the neoplasic progression to culminate in HNO cells with the loss of organogenic totipotency. [less ▲]

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See detailImmunohistochemical study of the rectus sheath and transversalis facia in adult groin hernias
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1999), 3

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See detailShort-term toxicity of various pharmacological agents on the in vitro nitrification process in a simple closed aquatic system
Nimenya, H.; Delaunois, Annie; La Duong, Duc ULg et al

in Alternatives to Laboratory Animals (1999), 27

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures ... [more ▼]

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures of nitrifying bacteria. The purpose of this study was to quantify the inhibitory effects of 15 pharmacological agents, which are often used as therapeutic agents in ichthyopathology, on ammonia removal and nitrate production in a simple closed aquatic system. The experiments were conducted in polyethylene bags containing activated biofilters and synthetic water solutions, held in a water bath. Ammonia was added to initiate the nitrification process, and graded concentrations of various pharmacological agents were added. The effects of the pharmacological agents on in vitro nitrification were assessed by monitoring ammonia and nitrate concentrations compared to controls with no added agents, for 24 hours. Graded concentrations of ampicillin (Albipen(R)), chloramine T, enrofloxacin (Baytril(R)), erythromycin, levamisole, methylene blue and polymyxin B induced dose-dependent inhibitions of ammonia removal and nitrate production. The corresponding linear regression curves showed high correlation coefficients and were highly significant (p < 0.05). The addition of chloramphenicol, copper (II) sulphate, kanamycin disulphate, malachite green, neomycin sulphate, potassium penicillin G, tetracycline and a mixture of trimethoprim and sulphadoxin (Duoprim(TM)) had no significant effects on the nitrification process. A significant dose-related inhibition of nitrate production, but not of ammonia oxidation, was observed with enrofloxacin. The significant correlation (r = 0.940; p < 0.001) between the degrees of inhibition of ammonia oxidation and nitrate production for the various inhibitory pharmacological agents has also been calculated, with a view to validating this method. The data presented suggest that separate tank facilities for hospitalisation or quarantine are necessary when treating diseased fish with ampicillin, enrofloxacin, chloramine T, erythromycin, levamisole, methylene blue or polymyxin B, in order to avoid ammonia poisoning. [less ▲]

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See detailPretransplant helper T-lymphocyte determination in bone marrow donors: acute graft-versus-host disease prediction and relation with long-term survival
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in British Journal of Haematology (1999), 105

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency ... [more ▼]

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency was estimated in limiting dilution cultures, and HLA-DR and CD 80 expression by stimulating cells was measured by flow cytometry. 12/19 patients experienced acute graft-versus-host disease (aGVHD) grade II–IV. A good correlation was found between high pretransplant HTLp frequency and grade II–IV aGVHD (median: 1/55848 PBMNC for II–IV GVHD versus 1/ 184346 for 0–I GVHD; P¼0·008). Sensitivity was 82%, specificity 63%, negative predictive value 71% and positive predictive value 75%. Long-term survivors also had a lower HTLp median frequency (1/143354) when compared with patients who died as a result of the transplant procedure (1/22100, P < 0·001). No correlation was found between HTLp frequency and HLA-DR or CD80 expression by patient’s cells. We conclude that HTLp frequency estimation can predict, although poorly, acute GVHD risk and long-term survival. [less ▲]

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See detailLifetime measurements in Yb II with time-resolved laser spectroscopy
Li, Z. S.; Svanberg, S.; Quinet, Pascal ULg et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailTarif de cubage "peuplement" pour les mélèzes en belgique méridionale
Pauwels, Dominique; Rondeux, Jacques ULg

in Revue Forestière Française (1999), 51(5), 605-611

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem ... [more ▼]

Dendrometric data taken from 150 temporary plots set up in even-aged stands of larch trees in southern Belgium (French-speaking region) were used to devise a "stand" volume table that expresses the stem solid volume (for log girths not less than 22 cm) per hectare of larch depending on the land surface areas and dominant tree heights. [less ▲]

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See detailQuête de reliques en Sardaigne pour le prieuré Saint-Léonard de Liège (1642-1650)
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (1999)

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See detailEffect of synthesis process and substrate on electrical and thermal transport properties of Bi-2212
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Bougrine, Hassan ULg et al

in Journal of Superconductivity (1999), 12(5), 623-629

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade ... [more ▼]

Resistivity, thermoelectric power, and thermal conductivity have been measured for a Bi-2212 system synthesized from a glassy precursor, either with a commercially Al2O3 substrate or with a homemade BaZrO3 substrate. Those measurements show that the BaZrO3 substrate gives better superconducting properties to the Bi-2212 than the Al2O3 substrate. The effect of (1.0 T) weak magnetic field has been searched for. The thermal magnetoconductivity and the contributions of the magnetic field to the thermoelectrical power are studied and compared through fine measurements. An electronic contribution seems to appear already well above the critical temperature and to exist up to 200 degrees K. The onset temperature is thus deduced. [less ▲]

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See detailRecommendations for the registration of drugs intended for use in the treatment of male osteoporosis
Kaufman, JM; Compston, J; Audran, MA et al

in Calcified Tissue International (1999), 65

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See detailCerebral metabolism during vegetative state and after recovery to consciousness
Laureys, Steven ULg; Lemaire, Christian ULg; Maquet, Pierre ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (1999), 67(1), 121-122

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See detailHigh Prevalence of Low Femoral Bone Mineral Density in Elderly Women Living in Nursing Homes or Community-Dwelling: A Plausible Role of Increased Parathyroid Hormone Secretion
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Pirenne, H. et al

in Osteoporosis International (1999), 9(2), 121-8

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH ... [more ▼]

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH vitamin D (25-OHD) with those of subjects living at home, in the immediate vicinity of the nursing homes. Of 1483 women, aged 70 years and older, who were selected, 993 agreed to participate in this trial. Their femoral neck BMD (n = 993) was measured by dual-energy X-ray absorptiometry, with a specific device installed in a mobile truck. The circulating levels of 25-OHD and PTH were assessed after an overnight fast (n = 748). After stratification for age, there were no significant differences in mean femoral neck BMD values, prevalence of femoral neck osteoporosis, mean serum 25-OHD and prevalence of absolute or relative 25-OHD deficiency between the two groups. Serum levels of PTH were significantly higher in women over 80 years old living in nursing homes, compared with the community-dwelling women. After adjustment for age, a significant relation was found between femoral neck BMD and PTH levels in the whole population (p = 0.004) and in community-dwelling subjects (p = 0.039). When stratifying our population by quartiles of serum PTH values, the odds ratios for femoral neck osteoporosis were significantly increased for the top two quartiles compared with the lowest one both before (p = 0.00146) and after (p = 0.0013) adjustment for age and type of housing. From this study we conclude that femoral osteoporosis is largely underestimated in European women. Living in a nursing home is not, per se, a risk factor for decreased femoral BMD, and circulating PTH levels are a key determinant of low femoral bone density and osteoporosis. [less ▲]

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See detailShelley in travestie: De vertaalstrijd om 'Alastor'
Steyaert, Kris ULg

in Filter: Tijdschrift over Vertalen (1999), 6(3), 28-36

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailPubertal Growth as a Determinant of Adult Height in Boys with Constitutional Delay of Growth and Puberty
Rensonnet, Claudie ULg; Kanen, F.; Coremans, C. et al

in Hormone Research (1999), 51(5), 223-9

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult ... [more ▼]

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (-0. 6 +/- 0.8, mean +/- SD) was similar to target height (-0.5 +/- 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty. Copyrightz1999S. KargerAG,Basel [less ▲]

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See detailA critical compilation and extended analysis of the Ne V spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the ... [more ▼]

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the present paper, Hartree-Fock calculations and least-squares fi ts over the whole set of the available data (including the most recent ones) have been performed. As a result, a comprehensive view of the Ne V spectrum is presented. 10 new energy levels and 40 newly classi fied lines are proposed. An improved value of the ionisation potential of Ne V is also proposed. [less ▲]

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See detailGEQUAC, an excess Gibbs energy model describing associating and non-associating liquid mixtures by a new model concept for functional groups
Egner, Katja; Gaube, Johann; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1999), 158(381-389),

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See detailThe Structural And Functional Organization Of H-Ns-Like Proteins Is Evolutionarily Conserved In Gram-Negative Bacteria
Bertin, P.; Benhabiles, N.; Krin, E. et al

in Molecular Microbiology (1999), 31(1), 319-29

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi ... [more ▼]

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi and Haemophilus influenzae. Isolated outside these groups, the BpH3 protein of Bordetella pertussis exhibits a low amino acid conservation with H-NS, particularly in the N-terminal domain. To obtain information on the structure, function and/or evolution of H-NS, we searched for other H-NS-related proteins in the latest databases. We found that HvrA, a trans-activator protein in Rhodobacter capsulatus, has a low but significant similarity with H-NS and H-NS-like proteins. This Gram-negative bacterium is phylogenetically distant from Escherichia coli. Using theoretical analysis (e.g. secondary structure prediction and DNA binding domain modelling) of the amino acid sequence of H-NS, StpA (an H-NS-like protein in E. coli), BpH3 and HvrA and by in vivo and in vitro experiments (e.g. complementation of various H-NS-related phenotypes and competitive gel shift assay), we present evidence that these proteins belong to the same class of DNA binding proteins. In silico analysis suggests that this family also includes SPB in R. sphaeroides, XrvA in Xanthomonas oryzae and VicH in Vibrio cholerae. These results demonstrate that proteins structurally and functionally related to H-NS are widespread in Gram-negative bacteria. [less ▲]

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See detailImplication des propriétés biomécaniques des muscles transformés dans le mécanisme de la cardiomyoplastie
Radermacker, M. A.; Sluse, Francis ULg; Focant, B. et al

in Journal of Cardiology (1999), 9

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See detailA critical compilation and extended analysis of the Ne IV spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete ... [more ▼]

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete and consistent up-to-date tables of spectral lines and energy levels, particularly of the neon-ions spectra, notably reduces possibilities of interpretation of astrophysical and laboratory spectra. In the present paper, all optical spectral lines of Ne IV observed in 24 previous works have been systematised together with recent observations made by means of the beam-foil method at Liège University. As a result of our extended analysis of the whole set of available data, 35 new energy levels have been found and 90 newly classi ed spectral lines have been listed for the Ne IV spectrum, only a few of them having been reported previously. A complete table of observed and classi ed spectral lines has been built, and the list of optimised energy levels has been derived from it in a consistent way. A new, improved, ionisation potential of Ne IV has been deduced from the experimental data. [less ▲]

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See detailSème inhérent et sème afférent. Examen des critères théoriques dans la sémantique interprétative de François Rastier
Badir, Sémir ULg

in Travaux de linguistique : revue internationale de linguistique Française (1999), 38

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques ... [more ▼]

La sémantique interprétative, dont la rentabilité des applications, tant dans les études littéraires que dans les analyse de bases de données lexicologiques, n’est plus à vanter, repose sur quelques critères théoriques relatifs à la détermination des différents types de sèmes (sème inhérent et sème afférent; sème spécifique et sème générique). On s’attache ici d’abord à montrer que ces critères, en dépit de leurs points d’ancrage dans la théorie structurale, ne sont pas définis de manière satisfaisante par François Rastier, initiateur et théoricien de cette sémantique. Puis on propose, au moins à titre d’hypothèse théorique dépourvue de contradiction, une nouvelle formulation des critères distinctifs des sèmes. [less ▲]

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See detailAccumulation of glycosidically bound compounds in Fragaria * ananassa cv. Elsanta fruits at various developmental stages.
Groyne, Joëlle; Lognay, Georges ULg; Marlier, Michel

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999), 3(1), 5-9

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a ... [more ▼]

Isolation of glycosidically bound compounds of Fragaria ´ ananassa cv. Elsanta was performed by Amberlite XAD-2 adsorption followed by methanol elution. After glycosidic extract hydrolysis with a commercial b-glucosidase and liquidliquid extraction with diethyl ether, on-line coupled capillary gas chromatographic - mass spectrometric (HRGC-MS) identification of the liberated aglycons was achieved. Five developmental stages of strawberry fruit were investigated during ripening. The occurrence and accumulation of glycosides were pointed out and several aglycons were identified in relation with the investigated developmental stages, with a maximum for the overripe fruit. [less ▲]

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See detailAlcoholic's deficit in the decoding of emotional facial expression
Philippot, P; Kornreich, C; Blairy, Sylvie ULg et al

in Alcoholism, Clinical & Experimental Research (1999), 23(6), 1031-1038

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See detailForest inventories and biodiversity
Rondeux, Jacques ULg

in Unasylva (1999), 50(196), 35-41

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See detailPregnancy Associated Glycoproteins in Ruminants: Inactive Members of the Aspartic Proteinase Family
Beckers, Jean-François ULg; Drion, Pierre ULg; Garbayo, J. M. et al

in Acta Veterinaria Hungarica (1999), 47(4), 461-9

The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase ... [more ▼]

The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase family. Pepsinogen, renin, cathepsin E [less ▲]

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See detailMicroscopic and laser granulometric analyses of hydrating cement suspensions
Lilkov, V.; Dimitrova, E.; Gaydardzhiev, Stoyan ULg

in Cement & Concrete Research (1999), 29

The results from microscopic and laser granulometric analyses of hydrating cement suspensions, containing active mineral additives are presented. Conclusions are drawn about the specific hydration ... [more ▼]

The results from microscopic and laser granulometric analyses of hydrating cement suspensions, containing active mineral additives are presented. Conclusions are drawn about the specific hydration processes of the investigated cements, as well as the applicability of laser granulometry for the study of cement and hydration products. [less ▲]

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See detailcompte rendu de : J. Sosephson, The Pahlavi Translation Technique as Illustrated by Hom Yast
Rochette, Bruno ULg

in Translatio (1999), 18(2), 294-297

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See detailMalathion Resistance Increases Male Reproductive Success In Tribolium Castaneum (Coleoptera : Tenebrionidae)
Arnaud, L.; Haubruge, Eric ULg; Gaspar, Charles ULg

in Annales de la Societe Entomologique de France (1999), 35

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See detailDesign of a microwave array hyperthermia applicator with a semicircular reflector
V Sabariego, Ruth ULg; Landesa, Luis; Obelleiro, Fernando

in Medical & Biological Engineering & Computing (1999), 37(5), 612-617

The design of a hyperthermia applicator for heating biological tissues is presented in which the applicator consists of an array antenna surrounded by a perfect electrically conducting reflector. The heat ... [more ▼]

The design of a hyperthermia applicator for heating biological tissues is presented in which the applicator consists of an array antenna surrounded by a perfect electrically conducting reflector. The heat hazard to superficial tissues is reduced by the introduction of a dielectric protecting layer over them. A method of moments formulation is applied to approximate the electric field within the biological medium and a closed form expression is presented for the electromagnetic coupling problem, which enables an optimisation procedure to be performed. The applicator enhances both penetration and focusing: deep tumours, close to the bone region, are heated and the percentage of biologically healthy tissue exposed to a specific absorption rate (SAR) hazard level diminishes by 53.8%. [less ▲]

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See detailLes Formations du Frasnien de la Belgique
Boulvain, Frédéric ULg; Bultynck, P.; Coen, M. et al

in Memoirs of the Geological Survey of Belgium (1999), 44

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See detailAlveolar clearance in horses with chronic obstructive pulmonary disease
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, D. H. et al

in American Journal of Veterinary Research (1999), 60

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive ... [more ▼]

OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive pulmonary disease (COPD; group B). PROCEDURE: Horses underwent clearance rate (k [%/min]) determination. Clearance rate of group-B horses was determined after remission of the disease following 2 months at pasture (remission 1), stabling in a controlled environment (remission 2), and during crisis induced by exposure to moldy hay and straw. Methacholine challenge test was performed at each investigation period to determine nonspecific pulmonary airway hyperresponsiveness. Pulmonary function tests (PFT) also were performed, and cell populations in bronchoalveolar lavage (BAL) fluid were determined on another occasion. RESULTS: Group-B horses had significantly faster mean clearance rate during crisis (k = 4.30+/-0.95%/min), compared with that for remission 1(k = 1.98+/-0.55%/min), which did not differ from the rate in group-A horses (k = 1.95+/-0.33%/min). Despite lack of clinical signs of COPD during remission when stabled in a controlled environment, an intermediate value was found (k = 3.20+/-0.72%/min). CONCLUSIONS: This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. CLINICAL RELEVANCE: Determination of alveolar clearance rate by use of scintigraphy is a sensitive indicator of lung damage. A modified clearance rate was found despite the lack of clinical and functional changes [less ▲]

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See detailThe SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory
Hubert, Philippe ULg; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Analytica Chimica Acta (1999), 391(2), 135-148

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data ... [more ▼]

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data evaluation are proposed by an SFSTP Commission dedicated to the validation of chromatographic methods in bioanalysis. In a series of meetings, members of this Commission have tried to elaborate a rational, practical and statistically reliable strategy to assure the quality of the analytical results generated. This strategy has been formalised in a guide and the main suggestions made by the Commission are summarised in the present paper. The SFSTP guide has been produced to help analysts from the pharmaceutical industry to validate their bioanalytical methods, It is the result of a consensus between professionals having expertise in bioanalytical and/or statistical fields. The suggestions presented in this paper should therefore help the analyst to design and perform the minimum number of validation experiments needed to obtain all the required information to establish and demonstrate the reliability of its analytical procedure. The SFSTP guide suggests a validation strategy in two steps: a pre-validation and the validation itself. An experimental design is described for each of these steps and the main aspects discussed in the paper are related to the selection of the most appropriate calibration model to fit experimental data and the most suitable way to determine the limit(s) of quantitation and subsequently the calibration range as well as the optimum number of experiments to be performed in the validation phase. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailDiagnostiquer les Troubles Spécifiques de l'Apprentissage
Garcet, Serge ULg

in Revue Scientifique de l'AIGS, (1999), 2

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See detailRecent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists)
De Tullio, Pascal ULg; Delarge, J.; Pirotte, Bernard ULg

in Current Medicinal Chemistry (1999), 6

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See detailLa césarienne dans l'espèce bovine
Hanzen, Christian ULg; Lourtie, O; Ectors, Francis

in Annales de Médecine Vétérinaire (1999), 143

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See detailEGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
Du, G.; Willet, K.; Mouithys-Mickalad, Ange ULg et al

in Free Radical Biology & Medicine (1999), 27

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to ... [more ▼]

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to impair respiratory activities and mitochondrial oxidative phosphorylation efficiency. ADP/O (2.57 +/- 0.11) decreased after anoxia/reoxygenation (1.75 +/- 0.09, p < .01), as well as state 3 and uncoupled respiration (-20%, p < .01), but state 4 respiration increased (p < .01). EGb 761 (50-200 microg/ml) had no effect on mitochondrial functions before anoxia, but had a specific dose-dependent protective effect after anoxia/reoxygenation. When mitochondria were incubated with 200 microg/ml EGb 761, they showed an increase in ADP/O (2.09 +/- 0.14, p < .05) and a decrease in state 4 respiration (-22%) after anoxia/reoxygenation. In EPR spin-trapping measurement, EGb 761 decreased the EPR signal of superoxide anion produced during reoxygenation. In conclusion, EGb 761 specially protects mitochondrial ATP synthesis against anoxia/reoxygenation injury by scavenging the superoxide anion generated by mitochondria [less ▲]

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See detailEffects on nicotine administered via a transdermal delivery system on vigilance : a repeated measure study
Mancuso, Giovanna; Andrès Bénito, Pilar; Ansseau, Marc ULg et al

in Psychopharmacology (1999), 142(1), 18-23

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing ... [more ▼]

Tested 15 male smokers (aged 18-25 yrs) in a within-Ss design to determine the influence of a transdermal patch of 21 mg nicotine on vigilance. Ss were tested on the Rapid Visual Information Processing test 1.3, 3 and 6.3 hrs after patch application, to verify the involvement of the dose of nicotine on the performance. The results confirm and extend the knowledge on the increasing effects of nicotine on vigilance previously found with orally and transdermally administered nicotine. Moreover, results show that such performance was independent of the time of nicotine absorption, which suggests that a relatively low dose of nicotine suffices to activate vigilance processing. Regarding motor performance, no convincing effect of nicotine was observed on reaction time. ((c) 1999 APA/PsycINFO, all rights reserved) [less ▲]

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detailL'analyse discriminante décisionnelle : principes et application
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (4), 41

The principles of discriminant analysis are described and illustrated by the iris data set published by Fisher [1936].

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See detailConstraint-generating dependencies
Baudinet, Marianne; Chomicki, Jan; Wolper, Pierre ULg

in Journal of Computer & System Sciences (1999), 59(1), 94-115

Traditionally, dependency theory has been developed for uninterpreted data. Specifically, the only assumption that is made about the data domains is that data values can be compared for equality. However ... [more ▼]

Traditionally, dependency theory has been developed for uninterpreted data. Specifically, the only assumption that is made about the data domains is that data values can be compared for equality. However, data is often interpreted and there can be advantages in considering data as such, for instance, obtaining more compact representations as is done in constraint databases. This paper considers dependency theory in the context of interpreted data. Specifically, it studies constraint-generating dependencies. These are a generalization of equality-generating dependencies where equality requirements are replaced by constraints on an interpreted domain. The main technical results in the paper are a general decision procedure for the implication and consistency problems for constraint-generating dependencies and complexity results for specific classes of such dependencies over given domains. The decision procedure proceeds by reducing the dependency problem to a decision problem for the constraint theory of interest and is applicable as soon as the underlying constraint theory is decidable. The complexity results are, in some cases, directly lifted from the constraint theory; in other cases, optimal complexity bounds are obtained by taking into account the specific form of the constraint decision problem obtained by reducing the dependency implication problem. (C) 1999 Academic Press. [less ▲]

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See detailPlants associated with Tentaculites in a new Early Devonian locality from Morocco.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Galtier, J et al

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailDissection of the GHER turbulence closure scheme
Delhez, Eric ULg; Grégoire, Marilaure ULg; Nihoul, Jacques ULg et al

in Journal of Marine Systems (1999), 21(1-4), 379-397

In this paper, the turbulence closure scheme implemented in the GHER hydrodynamic model is described in detail. Two case studies carried out in two contrasting conditions-one in the shallow, tide ... [more ▼]

In this paper, the turbulence closure scheme implemented in the GHER hydrodynamic model is described in detail. Two case studies carried out in two contrasting conditions-one in the shallow, tide dominated, north-western European continental shelf, and the other in the deep Mediterranean Sea-are used to identify the dominant terms of the equation for the turbulent kinetic energy, first theoretically, secondly from the results of the simulations. In both domains, the dominant terms are the local destruction and production terms, the vertical diffusion term and to a smaller degree, the time derivative. Advection and horizontal diffusion turn out to be negligible in most of the relevant cases for such large scale studies. This opens the way to simplifications and optimisations of the numerical models. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThe Locus for Enterocyte Effacement (Lee) of Enteropathogenic Escherichia Coli (Epec) from Dogs and Cats
Goffaux, F.; China, B.; Janssen, L. et al

in Advances in Experimental Medicine and Biology (1999), 473

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called ... [more ▼]

Enteropathogenic Escherichia coli (EPEC) produce attaching and effacing lesions. The genes responsible for this lesion are clustered on the chromosome forming a 35.5 kilobase pathogenesis island called LEE. The LEE was identified, characterized and completely sequenced from the human EPEC strain E2348/69. The LEE carries genes coding for: a type III secretion system (genes esc and sep), the translocated intimin receptor (gene tir), the outer membrane protein intimin (gene eae) and the E. coli secreted proteins EspA, EspB, and EspD (genes esp). In addition to man and farm animals, EPEC are also isolated from dogs and cats. We studied structurally and functionally the LEE of dog and cat EPEC. First, we used four probes scattered along the LEE to identify the presence of a LEE in canine and feline EPEC isolates. Second, by PCR, we checked the presence of genes homologous to eae, sep, esp, and tir genes in these strains. Third, since the four types of eae and tir genes were described, we developed a multiplex PCR in order to determine the type of eae and tir genes present in each strain. Fourth, we determined by PCR the site of the LEE insertion on the chromosome. Fifth, we tested several of the canine EPEC in their capacity to induce attaching and effacing lesions in the rabbit intestinal loop assay. We can conclude from this study: first, that the a LEE-like structure is present in all tested strains and that it contains genes homologous to esp, sep, tir, and eae genes; second, that there is some preferential associations between the type of eae gene and the type of tir gene present in a strain; third, that the majority of the tested strains contained a LEE located elsewhere on the chromosome in comparison to the human EPEC strain E2348/69; and fourth that dog EPEC were able to induce attaching and effacing lesions in rabbit ileal loop assay. [less ▲]

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See detailObservations sous Prés. Com. Bruxelles, 27 avril 1999
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1999)

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See detailRecombinant Production Of The P10(Cks1at) Protein From Arabidopsis Thaliana And C-13 And N-15 Double-Isotopic Enrichment For Nmr Studies
Landrieu, I.; Casteels, P.; Odaert, B. et al

in Protein Expression & Purification (1999), 16(1),

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See detailLes transferts post-mortem : réinterprétation symbolique du lieu d’enterrement dans un contexte de mobilité des populations
Schmitz, Serge ULg

in Espaces et Sociétés (Paris, France) (1999), 99

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery ... [more ▼]

This article is the result of the study of 10.000 burial certificates. It analyses the movement of corpses in an urban region which houses 510.000 peoples and tends to explain the motivation of cemetery choice. It underlines the connections between post-mortem mobility, the different levels of population mobility and culture. [less ▲]

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See detailModelling the propagation pathway of street-traffic noise : practical comparison of German guidelines and real-world measurements
Wetzel, Edgar; Nicolas, Jacques ULg; Andre, Philippe ULg et al

in Applied Acoustics (1999), 57(2), 97-107

In Germany, several guidelines were developed to model the noise propagation pathway. The study compares the guidelines DIN 18005, RLS-90 and VDI 2714, all of which provide some kind of sound object line ... [more ▼]

In Germany, several guidelines were developed to model the noise propagation pathway. The study compares the guidelines DIN 18005, RLS-90 and VDI 2714, all of which provide some kind of sound object line source suited to model street traffic noise. Differences between those guidelines are explained, and their effect on practical calculations is shown in a real-world situation, National Road N4, in Arlon, Belgium. Calculated results are compared to measurements made on critical points along the road. The paper emphasises the understanding of the inner workings of models. In order to avoid differences in calculated results due to software design methods applied, all calculations are made using one single commercially available simulation program. Additionally, this allows for a test of guideline sensitivity to changes in input parameters. [less ▲]

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See detailLe traitement des ectasies anevrysmales de l'aorte ascendante par l'intervention de Robicsek
RADERMECKER, Marc ULg; Laurent, S.; Limet, Raymond ULg

in Revue Médicale de Liège (1999), 54(11), 886-8

The technique and the results of the external contention of the dilated ascending aorta by the application of an external Dacron graft are reported. This technique, without replacing the usual graft ... [more ▼]

The technique and the results of the external contention of the dilated ascending aorta by the application of an external Dacron graft are reported. This technique, without replacing the usual graft interposition, can efficiently and expeditiously treat borderline dilatation of the ascending aorta, as frequently encountered in aortic valve disease. If the sinotubular junction is not dilated, this technique may stop the aneurysmal evolution of the ascending aorta. [less ▲]

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See detailL'etude clinique du mois. Interet d'augmenter un taux de cholesterol HDL bas en prevention secondaire de la coronaropathie: resultats de l'etude VA-HIT.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(9), 773-5

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary ... [more ▼]

The "Veterans Affairs Cooperative Studies Program High-Density Lipoprotein Cholesterol Intervention Trial" (VA-HIT) is a large randomised, double-blind, placebo-controlled clinical trial for the secondary prevention of coronary heart disease. It demonstrates that a fibrate treatment (gemfibrozil) significantly reduces the relative risk of major coronary (-22%, p = 0.006) and cardiovascular (-24%, p < 0.001) events in men with coronary heart disease whose primary lipid abnormality is a low HDL cholesterol level. These findings suggest that, in such a population, the rate of coronary events is reduced under gemfibrozil therapy by raising HDL cholesterol levels (+6%) and lowering levels of triglycerides (-31%) without lowering LDL cholesterol concentrations. [less ▲]

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See detailCompte rendu de J. VERGER, La renaissance du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1999)

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See detailFrom Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, Bernard ULg; Ben Hur, Tamir; Dubois-Dalcq, Monique

in Molecular & Cellular Neuroscience [=MCN] (1999), 14

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See detailEspace urbanisé et espace non urbanisé au Grand-Duché de Luxembourg.
Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1999), 36

The paper uses agriculture and forestry statistics to determine major trends of both urbanized and non urbanized development in the Grand Duchy of Luxembourg. It outlines the new morphological ... [more ▼]

The paper uses agriculture and forestry statistics to determine major trends of both urbanized and non urbanized development in the Grand Duchy of Luxembourg. It outlines the new morphological urbanization. The urban areas has been confined since the indsutrial revolution to the south west of the country. However during the seventies development was structured by the transport corridors extending from the capital and mining areas. Two new urban regions began also to develop : the "dipole" Ettelbürck-Diekirch and the Moselle valley. Recent trends of urban development is in contrast to the earlier trends characterized by wide spreads morphological urbanization notably in the Oesling. [less ▲]

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See detailEtude rétrospective de l'incidence des troubles nereux rapportés et suspects d'encéphalopathie spongiforme transmissible chez les bovins en Belgique
Saegerman, Claude ULg; Claes, M.; Vanopdenbosch, E. et al

in Epidémiologie et Santé Animale (1999), 35

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See detailL'obligation naturelle du père biologique de fournir des aliments à son enfant. Note sous Liège, 15 juin 1998
Genicot, Gilles ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailInfo-congres. L'etude HOPE: demonstration de la protection cardio-vasculaire du ramipril, un inhibiteur de l'enzyme de conversion de l'angiotensine.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(10), 835-6

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study were presented at the XXIst Congress of the European Society of Cardiology in Barcelona (August 28-September 1, 1999). In addition ... [more ▼]

The results of the HOPE ("Heart Outcomes Prevention Evaluation") study were presented at the XXIst Congress of the European Society of Cardiology in Barcelona (August 28-September 1, 1999). In addition, results obtained in the large diabetic sub-population (38% of the 9541 patients included in the trial) were reported at the XXXVth Congress of the European Association for the Study of Diabetes in Brussels (September 28-October 2, 1999). The HOPE trial was terminated early because of a reduction of the relative risk (-22%, p < 0.000002) of major cardiovascular events in the group treated with ramipiril compared to the group receiving placebo. Such a favourable effect of ramipril was observed in non-diabetic subjects in secondary prevention and in diabetic patients in secondary or primary prevention. In the latter population, a significant reduction in the incidence of microangiopathic complications (nephropathy and retinopathy) was also demonstrated. [less ▲]

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailL'homeopathie est-elle superieure au placebo? Controverse a propos d'une meta-analyse des etudes controlees.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(7-9), 295-304304-7

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not ... [more ▼]

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not rely on any scientific basis, it appears to be popular, especially in general practice. The homeopaths have recently taken arguments from a meta-analysis published in 1997 in the Lancet of 89 placebo-controlled trials. This study indeed concluded that the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo. However, this meta-analysis contains several methodological flaws. Furthermore, it is recognized that results of a meta-analysis may not be confirmed in large well-performed clinical trials. Thus, homeopathy should still provide the evidence that conventional medicine has regularly brought during the last two decades in many fields of therapeutics, with the respect of the rigorous rules of "Good Clinical Practice", leading to "Evidence-Based Medicine". [less ▲]

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailMedicaments et grossesse.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(5), 409-14

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the ... [more ▼]

Since the dramatic observations of fetal abnormalities associated to thalidomide use during pregnancy, the risk of malformations when prescribing drugs in pregnant women is a well-known problem, among the public as well as among medical doctors. However, the complexity of the problem, the lack of robust scientific data and the emotional context characterizing this period make the prescription of medications to a pregnant woman a difficult task for every people involved in health care, the pharmacist, the general practitioner and even the gynaecologist. [less ▲]

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See detailOverexpression, purification and characterization of Mycobacterium bovis BCG alcohol dehydrogenase.
Wilkin, J. M.; Soetaert, K.; Stelandre, M. et al

in European Journal of Biochemistry (1999), 262(2), 299-307

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell ... [more ▼]

A previous study of the effect of zinc deprivation on Mycobacterium bovis BCG pointed out the potential importance of an alcohol dehydrogenase for maintaining the hydrophobic character of the cell envelope. In this report, the effect of the overexpression of the M. bovis BCG alcohol dehydrogenase (ADH) in Mycobacterium smegmatis and M. bovis BCG is described. The purification of the enzyme was performed to apparent homogeneity from overexpressing M. bovis BCG cells and its kinetic parameters were determined. The enzyme showed a strong preference for both aromatic and aliphatic aldehydes while the corresponding alcohols were processed 100-1000-fold less efficiently. The best kcat/Km values were found with benzaldehyde > 3-methoxybenzaldehyde > octanal > coniferaldehyde. A phylogenetic analysis clearly revealed that the M. bovis BCG ADH together with the ADHs from Bacillus subtilis and Helicobacter pylori formed a sister group of the class C medium-chain alcohol dehydrogenases, the plant cinnamyl alcohol dehydrogenases (CADs). Comparison of the kinetic properties of our ADH with some related class C enzymes indicated that the mycobacterial enzyme substrate profile resembled that of the CADs involved in plant defence rather than those implicated in lignification. A possible role for the M. bovis BCG ADH in the biosynthesis of the lipids composing the mycobacterial cell envelope is proposed. [less ▲]

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See detailLes adénovirus recombinants comme vecteurs vaccinaux
Gogev, S.; Thiry, Etienne ULg

in Annales de Médecine Vétérinaire (1999), 143

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See detailLa Société nationale de la Petite Propriété Terrienne, Une institution entre ville et campagne
Mougenot, Catherine ULg

in Cahiers de l'Urbanisme (Les) (1999), (25-26), 42-45

Les maisons « terriennes » font partie de bon nombre de villes et villages. On connait pourtant mal l’origine de ces nombreux quartiers dont l’histoire se fonde dans l’attachement au jardin et la maitrise ... [more ▼]

Les maisons « terriennes » font partie de bon nombre de villes et villages. On connait pourtant mal l’origine de ces nombreux quartiers dont l’histoire se fonde dans l’attachement au jardin et la maitrise d’un environnement proche, un attrait que l’on redécouvre largement aujourd’hui. [less ▲]

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See detailComparison of performance, water intake and feeding behaviour of weaned pigs fed either pellets or meal
Laitat, Martine ULg; Vandenheede, Marc ULg; Desiron, Alain et al

in Animal Science (1999), 69

Performance, water intake and feeding behaviour of two groups of 30 (trial 1), 40 (trial 2) or 50 (trial 3) weaned pigs offered either pellets ol meal of the same formulation were compared. Average daily ... [more ▼]

Performance, water intake and feeding behaviour of two groups of 30 (trial 1), 40 (trial 2) or 50 (trial 3) weaned pigs offered either pellets ol meal of the same formulation were compared. Average daily weight gains (ADG) were higher for pigs given pellets rather than meal in trials 2 (413 v. 363 g/day P < 0.001) and 3 (356 v. 324 g/day, P < 0.05). Mean daily water intake (DWI) was higher with meal than with pellets but only during trial 1 (2.31 y. 1.65 l/day, P < 0.01). The occupation time (OT) and the number of animals using the feeder simultaneously (N) were higher when pigs were given meal rather than pellets, whatever the animal density: trial 1: 82.6 v. 69.9% (P = 0.05) and 3.8 v. 2.3 (P < 0.01); trial 2: 90.9 v. 77.9% (P > 0.05) and 5.2 v. 3.1 (P < 0.01); trial 3: 96.2 v. 83.6% (P < 0.05) and 5.9 v. 3.8 (P < 0.01). When using pellets, OT and N were always significantly lower during the night than during the day but when using meal in groups of 40 and 50, OT during the night was almost as high as during the day. The greater the group size, the lower were ADG (both diets) and DWI (only with meal) and the higher were OT and N (both diets). Furthermore, significant linens and curvilinear regressions of DWI, OT and N according to time were calculated. In conclusion, pigs need more time to eat meal than to eat pellets. Thus the number of pigs per feeder has to be adapted to the food presentation. Too high number of pigs per feeder impairs feeding behaviour and eventually welfare, by preventing preferential diurnal feeding activity and this may affect productivity [less ▲]

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See detailThe effects of training on ventilation and blood gases in exercising Thoroughbreds
Roberts, C. A.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal. Supplement (1999), 30

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the ... [more ▼]

The effects of training on ventilation and blood gases during exercise were investigated in 6 clinically normal, detrained Thoroughbred horses. They underwent a 16 week training programme similar to the type frequently used for Thoroughbred racehorses in Great Britain. Standardized treadmill exercise tests (2 min canter at 8 and 10 m/s C8 and C10[ and 2 min gallop at 12 m/s [G12], on a level surface) were performed prior to and after 16 weeks of training. Respiratory flow rates were measured using ultrasound flow transducers. Blood samples were drawn from a transverse facial artery and the right atrium. Minute ventilation, respiratory frequency and tidal volume were not significantly altered by training. Peak inspiratory flow rate was lower following training at 8 and 10 m/s, but not at 12 m/s. Arterial oxygen tension was decreased during trot and canter following training. Blood lactate concentration post G12 decreased following training (10.5 +/- 2.2 mmol/l vs. 7.7 +/- 2.2 mmol/l; P < 0.05). The increase in the degree of exercise-induced arterial hypoxaemia following training may reflect a lack of pulmonary adaptation to training in the face of improved cardiovascular and muscular function. [less ▲]

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See detailLes etudes cliniques controlees, support incontournable de la medecine basee sur l'evidence.
Scheen, André ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1999), 54(1), 1

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See detailThe DmpA aminopeptidase from Ochrobactrum anthropi LMG7991 is the prototype of a new terminal nucleophile hydrolase family.
Fanuel, L; Goffin, Colette ULg; Cheggour, A et al

in Biochemical Journal (1999), 341(Pt 1), 147-55

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are ... [more ▼]

The DmpA (d-aminopeptidase A) protein produced by Ochrobactrum anthropi hydrolyses p-nitroanilide derivatives of glycine and d-alanine more efficiently than that of l-alanine. When regular peptides are utilized as substrates, the enzyme behaves as an aminopeptidase with a preference for N-terminal residues in an l configuration, thus exemplifying an interesting case of stereospecificity reversal. The best-hydrolysed substrate is l-Ala-Gly-Gly, but tetra- and penta-peptides are also efficiently hydrolysed. The gene encodes a 375-residue precursor, but the active enzyme contains two polypeptides corresponding to residues 2-249 (alpha-subunit) and 250-375 (beta-subunit) of the precursor. Residues 249 and 250 are a Gly and a Ser respectively, and various substitutions performed by site-directed mutagenesis result in the production of an uncleaved and inactive protein. The N-terminal Ser residue of the beta-subunit is followed by a hydrophobic peptide, which is predicted to form a beta-strand structure. All these properties strongly suggest that DmpA is an N-terminal amidohydrolase. An exploration of the databases highlights the presence of a number of open reading frames encoding related proteins in various bacterial genomes. Thus DmpA is very probably the prototype of an original family of N-terminal hydrolases. [less ▲]

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See detailMorphotypes et postures de vie et de mort chez les trilobites.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1999), 56

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See detailAbsence of response to early transcranial magnetic stimulation in ischemic stroke patients: prognostic value for hand motor recovery.
Pennisi, Giovanni; Rapisarda, Giuseppe; Bella, R. et al

in Stroke (1999), 30(12), 2666-70

BACKGROUND AND PURPOSE: Transcranial magnetic stimulation (TMS) has been proposed as a prognostic tool in stroke patients. Most of the previous studies agree in considering the presence of motor-evoked ... [more ▼]

BACKGROUND AND PURPOSE: Transcranial magnetic stimulation (TMS) has been proposed as a prognostic tool in stroke patients. Most of the previous studies agree in considering the presence of motor-evoked potentials (MEPs) in the first days after a stroke as an indicator of good outcome. In the present study, we have assessed the prognostic value of the absence of response to early TMS on hand motor recovery in stroke patients with complete hand palsy at onset due to ischemia in the area of the middle cerebral artery. METHODS: Fifteen patients submitted to TMS within 48 hours of stroke onset (defined as day 1) and again after 1 year. They were also evaluated clinically on day 1 by a scale derived from the Medical Research Council (MRC) and by the National Institutes of Health (NIH) stroke scale; they were reevaluated by the same scales and by Barthel Index on day 365. RESULTS: On day 1, all the patients had complete hand palsy and no response to TMS; their NIH scores showed great variability. After 1 year, 6 of 15 patients regained small and prolonged MEPs, together with a very poor and not functionally useful motor recovery. NIH scores were significantly improved. Barthel Index scores showed large interindividual differences and were not correlated with MRC scores. CONCLUSIONS: We conclude that in patients with complete hand palsy, the absence of response to TMS in the first hours is predictive of absent or very poor, not useful, hand motor recovery. [less ▲]

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See detailData-model comparison using fuzzy logic in paleoclimatology.
Guiot, Joël; Boreux, Jean-Jacques ULg; Braconnot, P. et al

in Climate Dynamics (1999), 15(8), 569-581

Until now, most paleoclimate model-data comparisons have been limited to simple statistical evaluation and simple map comparisons. We have applied a new method, based on fuzzy logic, to the comparison of ... [more ▼]

Until now, most paleoclimate model-data comparisons have been limited to simple statistical evaluation and simple map comparisons. We have applied a new method, based on fuzzy logic, to the comparison of 17 model simulations of the mid-Holocene (6 ka BP) climate with reconstruction of three bioclimatic parameters (mean temperature of the coldest month, MTCO, growing degree-days above 5 °C, GDD5, precipitation minus evapotranspiration, P−E) from pollen and lake-status data over Europe. With this method, no assumption is made about the distribution of the signal and on its error, and both the error bars related to data and to model simulations are taken into account. Data are taken at the drilling sites (not using a gridded interpolation of proxy data) and a varying domain size of comparison enables us to make the best common resolution between observed and simulated maps. For each parameter and each model, we compute a Hagaman distance which gives an objective measure of the goodness of fit between model and data. The results show that there is no systematic order for the three climatic parameters between models. None of the models is able to satisfactorily reproduce the three pollen-derived data. There is larger dispersion in the results for MTCO and P−E than for GDD5. There is also no systematic relationship between model resolution and the Hagaman distance, except for P−E. The more local character of P−E has little chance to be reproduced by a low resolution model, which can explain the inverse relationship between model resolution and Hagaman distance. The results also reveal that most of the models are better at predicting 6 ka climate than the modern climate. [less ▲]

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See detailHypnosedation: a valuable alternative to traditional anaesthetic techniques.
Faymonville, Marie-Elisabeth ULg; Meurisse, Michel ULg; Fissette, Jean ULg

in Acta Chirurgica Belgica (1999), 99(4), 141-6

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since ... [more ▼]

Hypnosis has become routine practice in our plastic and endocrine surgery services. Revivication of pleasant life experiences has served as the hypnotic substratum in a series of over 1650 patients since 1992. In retrospective studies, followed by randomised prospective studies, we have confirmed the usefulness of hypnosedation (hypnosis in combination with conscious IV sedation) and local anaesthesia as a valuable alternative to traditional anaesthetic techniques. The credibility of hypnotic techniques and their acceptance by the scientific community will depend on independently-confirmed and reproducible criteria of assessing the hypnotic state. Based on the clinical success of this technique, we were interested in confirming this phenomenon in healthy volunteers. The revivication of pleasant life experiences thus served as the cornerstone of a basic research program developed to objectify the neurophysiological attributes of the hypnotic state. We compared hypnosis to normal alertness with similar thought content. In our experience, the activation profile obtained during the hypnotic state was completely different from simple re-memoration of the same subject matter during normal alertness. This represents an objective and independent criteria by which to assess the hypnotic state. [less ▲]

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See detailA comparison of advanced thermal cycles suitable for upgrading existing power plant
Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Applied Thermal Engineering (1999), 19(3), 227-237

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants ... [more ▼]

In view of the constant growth of electricity usage and public pressure to reduce the dependence on nuclear power plants in the energy supply, solutions are sought to increase the capacity of power plants using fossil fuels. Highly efficient cycles are available : gas turbines combined with waste heat boilers and steam cycles are able to achieve efficiencies above 50-55%. However building new plants requires a large amount of capital. Alternative proposals are based on upgrades of existing plants : capital savings are expected by reusing part of the facilities. In the present study, three parallel proposals are compared on the basis of exergy efficiency; cost of investment and flexibility of operation are also discussed. They are compared with classical Rankine cycle and state of the art combined cycles. (C) 1998 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailStructure of high temperature fluid selenium
Bichara, C.; Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg

in Journal of Non-Crystalline Solids (1999), 250-252

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures ... [more ▼]

Monte Carlo simulations based on a semi empirical tight binding model including dispersion forces were performed to study liquid selenium at temperatures between 600 and 2000 K. The atomic structures obtained are in agreement with the X-ray scattering and extended X-ray absorption fine structure (EXAFS) data in a range of temperatures and densities. A correlation between the conductivity of high temperature fluid selenium and the degree of branching and breaking of the selenium chains is observed [less ▲]

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See detailA Galerkin projection method for mixed finite elements
Geuzaine, Christophe ULg; Meys, B.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1438--1441

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See detailLa découverte d'or natif dans le quartzite devellien de Hourt autorise un autre regard sur le site de Rompt-le-Cou
Hanson, Alain ULg; Dehove, J.; Debbaut, Vincent ULg et al

in Glain et Salm. Haute Ardenne (1999), 51

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailLa dysplasie fibromusculaire
VAN DAMME, Hendrik ULg; Quaniers, Janine ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1999), 54(12), 935-42

Fibromuscular dysplasia is a rare non-atherosclerotic, non-inflammatory arterial disease. It concerns less than 1% of all occlusive artery lesions, but is more common in young female patients, with a ... [more ▼]

Fibromuscular dysplasia is a rare non-atherosclerotic, non-inflammatory arterial disease. It concerns less than 1% of all occlusive artery lesions, but is more common in young female patients, with a prevalence of 3 to 5% of the arterial lesions in that age group. It mainly attains renal and carotid arteries. The authors discuss the etiopathogeny, the prevalence and treatment of fibromuscular dysplasia. Their own surgical experience with 21 renal and 10 carotid lesions of fibromuscular is exposed. [less ▲]

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See detailModélisation spatiale de la sélection de l'habitat chez le Blaireau européen (Meles meles) au moyen d'un Système d'Information Géographique.
Vanhalle, L.; Defourny, P.; Dufrêne, Marc ULg

in Cahiers des Réserves Naturelles -Rnob (1999), 13

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See detailConvergence of High Order Curl-Conforming Finite Elements
Geuzaine, Christophe ULg; Meys, B.; Dular, Patrick ULg et al

in IEEE Transactions on Magnetics (1999), 35(3), 1442--1445

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See detail- Evolution of lipoxygenase activity during storage of potato tubers (Solanum tuberosum L. cv. Bintje)
Fauconnier, Marie-Laure ULg; Koto, N.; Hoyaux, P. et al

in Bulletin de la Société des Sciences de Liège (1999), 68(5-6), 319

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See detailPosterior epidural migration of sequestered lumbar disc fragments. Report of two cases.
Robe, Pierre ULg; Martin, Didier ULg; Lenelle, Jacques ULg et al

in Journal of Neurosurgery (1999), 90(2 Suppl), 264-6

The posterior epidural migration of sequestered lumbar disc fragments is an uncommon event. The authors report two such cases in which patients presented with either intense radicular pain or cauda equina ... [more ▼]

The posterior epidural migration of sequestered lumbar disc fragments is an uncommon event. The authors report two such cases in which patients presented with either intense radicular pain or cauda equina syndrome. The radiological characteristics were the posterior epidural location and the ring enhancement of the mass after injection of contrast material. The major diagnostic pitfalls are discussed. [less ▲]

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailEvaluer et rééduquer les difficultés morpho-syntaxiques chez le jeune enfant : Du geste au langage
Comblain, Annick ULg

in Bulletin d'Audiophonologie (1999), 15(2), 223-236

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une ... [more ▼]

L’acquisition du langage est, pour la majorité des enfants, rapide et harmonieuse. Entre l’apparition des premiers mots conventionnels et la maîtrise des structures syntaxiques de la lange maternelle, une petite dizaine d’années s’écoulent. Pour 7 à 8 % des enfants, le langage va se développer plus lentement et plus laborieusement et pour 1%, le retard sera sévère et persistant en dehors de toute prise en charge logopédique spécifique. Chez ces enfants en difficultés d’apprentissage du langage, les aspects morphosyntaxiques de la langue restent une difficulté majeure et une pierre d’achoppement non négligeable dans le processus de rééducation. Il est donc crucial dans une démarche d’évaluation du langage d’évaluer cette composante langagière de manière complète et précise de manière à, d’une part poser un diagnostic fiable et quantifier l’ampleur du retard et des troubles de développement, et, d’autre part, à fixer avec le plus d’exactitude et de minutie possible les objectifs d’une rééducation. [less ▲]

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See detailThe Indotriradites dolianitii Morphon, a distinctive group of miospore species from the Lower Carboniferous of Gondwana.
Loboziak; Melo, J.H.G.; Playford, G et al

in Review of Palaeobotany and Palynology (1999), 107

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See detailSome phase equilibrium constraints on the origin of Proterozoic (massif) anorthosites and related rocks
Longhi, John ULg; Vander Auwera, Jacqueline ULg; Fram, Miranda S. et al

in Journal of Petrology (1999), 40

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See detailA Natural Method for Coupling Magnetodynamic H-Formulations and Circuit Equations
Dular, Patrick ULg; Geuzaine, Christophe ULg; Legros, Willy ULg

in IEEE Transactions on Magnetics (1999), 35(3), 1626--1629

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See detailA scintigraphic study of post-massage blood flow in human lower limb
Vanderthommen, Marc ULg; Depresseux, J.C.; Dauchat, L. et al

in European Journal of Physical Medicine & Rehabilitation (1999), 8(6), 159-162

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See detailPremier signalement du Phytophthora de l’aulne (Alnus glutinosa) en Belgique
Cavelier, marc; Claessens, Hugues ULg; Etienne, Michel

in Parasitica (1999), 55

Detailed reference viewed: 30 (2 ULg)