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See detailCloning of a human GHF-1/Pit-1 cDNA variant
Pernasetti, Flavia; Wera, Stefaan; Belayew, Alexandra et al

in Nucleic Acids Research (1993), 21(15), 3584

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See detailFouilles paléolithiques 1992 en Belgique
Otte, Marcel ULg; Straus, Lawrence; Gautier, Achilles et al

in Notae Praehistoricae (1993), 12

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See detailSemi-Quantitative Salicin Analysis According the German Pharmacopoeia (DABX): Avoidance of Picein Interference
Poukens-Renwart, Pascale; Tits, Monique ULg; Angenot, Luc ULg

in Planta Medica (1993), 59(Supplement Issue), 629-630

The semi-quantitative determination of salicin by TLC described in the German Pharmacopoeia (DABX) does not separate salicin from picein, another phenolic glycoside of some willow species. In this paper ... [more ▼]

The semi-quantitative determination of salicin by TLC described in the German Pharmacopoeia (DABX) does not separate salicin from picein, another phenolic glycoside of some willow species. In this paper we propose to combine the use of both an adequate mobile phase and a suitable reagent (vanillin reagent instead of sulfuric acid-thymol) for an unambiguous determination of the amount of salicin.. [less ▲]

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See detailEvaluation of efficacy and safety of oral tiludronate in Paget's disease of bone: a double-blind, dose-ranging, placebo-controlled study
Reginster, Jean-Yves ULg; Colson, F; Morlock, G et al

in Arthritis and Rheumatism (1993), 36

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See detailMesurer les compétences en lecture: Apports et limites d'une enquête internationale
Lafontaine, Dominique ULg

in Lettre de la DFLM (La) (1993), 12

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See detailAn overview of the kinetic parameters of class B beta-lactamases.
Felici, A; Amicosante, G; Oratore, A et al

in Biochemical Journal (1993), 291 ( Pt 1)

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme ... [more ▼]

The catalytic properties of three class B beta-lactamases (from Pseudomonas maltophilia, Aeromonas hydrophila and Bacillus cereus) were studied and compared with those of the Bacteroides fragilis enzyme. The A. hydrophila beta-lactamase exhibited a unique specificity profile and could be considered as a rather specific 'carbapenemase'. No relationships were found between sequence similarities and catalytic properties. The problem of the repartition of class B beta-lactamases into sub-classes is discussed. Improved purification methods were devised for the P. maltophilia and A. hydrophila beta-lactamases including, for the latter enzyme, a very efficient affinity chromatography step on a Zn(2+)-chelate column. [less ▲]

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See detailonce a day administration of amikacine in neonates: assessment of nephrotoxicity and ototoxicity
Battisti, Oreste ULg; Langhendries, J. P.; Bertrand, J. M. et al

in Developmental Pharmacology and Therapeutics (1993), 20

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See detailDynamics of mitotic activity and expression of viral proteins gp51 and p24 of Bovine Leukemia Virus producing cells.
Roussev, Roussi; Polianova, M.; Portetelle, Daniel ULg et al

in Folia Biologica (1993), 39

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See detailDe lugebere droom van W.F. Hermans. Hermans'mythologie in het licht van A. Schopenhauer
Yans, Baudoin ULg

in Spiegel der Letteren (1993), (1), 47-61

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See detailA sulfonylthiourea (BM 20) related to torasemide: a new loop diuretic with relative potassium-sparing properties
Masereel, B.; Schynts, M.; Krzesinski, Jean-Marie ULg et al

in Journal of Pharmacy & Pharmacology (1993), 45

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé ... [more ▼]

A series of sulphonylthioureas related to torasemide, a high ceiling loop diuretic, were synthesized and found to inhibit the Na+ 2Cl- K+ co-transporter of the thick ascending limb of the loop of Henlé. Their diuretic properties were studied (30 mg kg-1) after oral administration to rats. Lipophilic derivatives very active in-vitro, were found inactive orally and intraperitoneally in rats. The four most active compounds were examined for their dose-dependent diuresis. Three of them showed a potency, water and electrolyte excretion similar to torasemide. The fourth molecule, a sulphonylthiourea (BM 20), exhibited relative potassium-sparing properties and a minimal diuretic dose of 0.001 mg kg-1, 200 times lower than torasemide. [less ▲]

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See detailLa production des noms propres
Brédart, Serge ULg

in Revue de Neuropsychologie (1993), 3

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See detailEssential oil production by Anthemis nobilis L. tissue culture.
Fauconnier, Marie-Laure ULg; Jaziri, M.; Marlier, Michel et al

in Journal of Plant Physiology (1993), 141(6), 759-761

The production of essential oil by tissue culture s ol Antbemis nobilis L. including cell suspension, shoot and crown-gall cultures is reported. The biosynthetic capability of these different cultures was ... [more ▼]

The production of essential oil by tissue culture s ol Antbemis nobilis L. including cell suspension, shoot and crown-gall cultures is reported. The biosynthetic capability of these different cultures was compared with that of plants grown in a field. The addition of crude polysaccharide fraction prepared from yeast extract and from the plant itself to shoot cultures affected the composition and total essential content (from 0.08 o/o to 0.3Qo/o dry weight). The essential oil content of the crown-gall tissue ol A. nobilis was 0.25 % of the dry weight and the composition of the essential oil was comparable to that of the flowers. [less ▲]

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See detailA model for the origin and petrogenesis of the red stromatactis limestone of Paleozoic carbonate mounds
Bourque, P. A.; Boulvain, Frédéric ULg

in Journal of Sedimentary Petrology (1993), 63(4), 607-619

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See detailThe distensibility of the central bronchial system in calves measured by means of the monofrequency oscillation technique
Reinhold, P.; Barnikol, W. K. R.; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40

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See detailEchec des élèves, échec de l'école ?
Crahay, Marcel ULg

in Recherche en Education. Théorie & Pratique (1993), 11-12

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See detailProductive Performance of the French Insurance Industry
Fecher-Bourgeois, Fabienne ULg; Kessler, D.; Perelman, Sergio ULg et al

in Journal of Productivity Analysis (1993), (4), 77-93

The purpose of this paper is to provide for both life and non-life insurance an assessment of the relative productive performance of French companies. We use parametric and nonparametric approaches to ... [more ▼]

The purpose of this paper is to provide for both life and non-life insurance an assessment of the relative productive performance of French companies. We use parametric and nonparametric approaches to construct a frontier to be used as a yardstick of productive efficiency. Our data basis covers 84 life and 243 non-life companies for the period 1984-1989. The main findings show a high correlation between parametric and nonparametric results and a wide dispersion in the rates of inefficiency across companies. This dispersion can be reduced when controlling for variations in scale, ownership, distribution, reinsurance, and claims ratios. [less ▲]

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See detailAérosolthérapie chez le cheval : 3. Etude clinique
Lekeux, Pierre ULg; Genicot, Bruno; Votion, Dominique ULg et al

in Pratique Vétérinaire Equine (1993), 25(4), 245-248

This review analyzes the advantages, disadvantages, limites and clinical applications of aerosoltherapy in equine medicine

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See detailAnalytical calculation of the electrostatic interaction energy within the CNDO framework
Dehareng, Dominique ULg; Dive, Georges ULg; Ghuysen, Jean-Marie ULg

in International Journal of Quantum Chemistry (1993), 46(6), 711-734

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab ... [more ▼]

This work analyses the adequacy of an analytical electrostatic energy formulation within the CNDO framework to predict the stable conformations of large molecular complexes. Comparisons are made with ab initio results for small systems such as water-formamide, methanol-water-imidazole, or guanine-cytosine and with AM1 results for two large systems: a molecular tweezer + the 9-methyladenine complex and a model active site of the alpha-chymotrypsin and its ligand complex. This approach is efficient in providing reliable conformers for large molecular systems in a very fast way. [less ▲]

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See detailLa didactique universitaire : des méthodes et techniques à la redéfinition des objectifs
Merenne-Schoumaker, Bernadette ULg

in Education-Formation (1993), (232), 25-32

Courte réflexion sur la pédagogie universitaire portant à la fois sur les méthode set techniques et les objectifs de l'enseignement

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See detailAccelerated erythroid repopulation with no stem-cell competition effect in children treated with recombinant human erythropoietin after allogeneic bone marrow transplantation.
Locatelli, F.; Zecca, M.; Beguin, Yves ULg et al

in British Journal of Haematology (1993), 84(4), 752-4

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) to accelerate erythropoietic engraftment in paediatric patients undergoing allogeneic BMT. rHuEPO was administered ... [more ▼]

We carried out a pilot study on the use of recombinant human erythropoietin (rHuEPO) to accelerate erythropoietic engraftment in paediatric patients undergoing allogeneic BMT. rHuEPO was administered intravenously at a dose of 75 U/kg per day for 30 d after transplant. Erythroid repopulation, evaluated sequentially through the serum transferrin receptor, was faster in 15 patients receiving rHuEPO than in 16 historical controls (P = 0.0003). This faster erythroid engraftment resulted in a reduction in the total number of red blood cell units required to reach transfusion independence (2.7 +/- 1.2 v 4.2 +/- 2.3, P = 0.027). No significant difference in leucocyte or platelet regeneration was observed. These findings indicate that rHuEPO administration can accelerate erythroid recovery after allogeneic BMT and reduce red cell transfusion requirements with no stem-cell competition effect. [less ▲]

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See detailIntercultural Education in French-speaking Belgium : an overview of ideology, legislation and practice
Martiniello, Marco ULg; Manço, Altay

in European Journal of Intercultural Education (1993), 4(2), 19-28

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See detailIn vivo infection of sheep by bovine leukemia virus mutants.
Willems, Luc ULg; Kettmann, Richard ULg; Dequiedt, Franck ULg et al

in Journal of virology (1993), 67(7),

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See detailCytokine and anti-cytokine strategies in inflammatory reaction modulation
Delannoy, I.; Lekeux, Pierre ULg; Miossec, P.

in Veterinary Research (1993), 24

Evidence of the importance of a cytokine cascade in the induction and control of the inflammatory reaction is increasing. Although cytokines are required in the inflammatory process in response to ... [more ▼]

Evidence of the importance of a cytokine cascade in the induction and control of the inflammatory reaction is increasing. Although cytokines are required in the inflammatory process in response to infection or injury, their overproduction, particularly that of interleukin-1 (IL-1) and tumor necrosis factor (TNF), can lead to local/systemic pathology. Selective inhibition of the synthesis or of the action of specific cytokines may be of therapeutic benefit. Various strategies for blocking IL-1 and TNF activities have been presented. While selective inhibition of cytokine synthesis is still in the early experimental phase, specific blockade of soluble cytokine action following synthesis and release from cells is undergoing preliminary clinical trials in humans. Animal data suggest that antimonoclonal therapy such as monoclonal antibodies to TNF, IL-1 receptor antagonists or soluble receptors to TNF and IL-1 can be effective in the modulation of the inflammatory reaction. Modulation of the cytokine network in some diseases might also include the use of anti-inflammatory cytokines. Nonetheless, the possibilities of side effects due to impaired host-defense mechanisms with the IL-1 or TNF blockade must also be taken into consideration. [less ▲]

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See detailinfections par streptocoque B en période néonatale
Battisti, Oreste ULg; Vanclaire, J.; François, A. et al

in Archives Françaises de Pédiatrie (1993), 50

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See detailLa gestion de l'espace - Avant-propos
Bock, Laurent ULg

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3), 115-119

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See detailPHOTOREDUCTION OF PROTOCHLOROPHYLLIDE TO CHLOROPHYLLIDE IN 2-D-OLD DARK-GROWN BEAN (PHASEOLUS-VULGARIS CV COMMODORE) LEAVES - COMPARISON WITH 10-D-OLD DARK-GROWN (ETIOLATED) LEAVES
SCHOEFS, B.; Franck, Fabrice ULg

in Journal of Experimental Botany (1993), 44(263), 1053-1057

Two-d-old leaves which do not contain prolamellar bodies synthesize active protochlorophyllide in darkness. When protochlorophyllide is photoreduced by one intense white flash, a main chlorophyllide ... [more ▼]

Two-d-old leaves which do not contain prolamellar bodies synthesize active protochlorophyllide in darkness. When protochlorophyllide is photoreduced by one intense white flash, a main chlorophyllide species emitting at 690 nm is formed. After the photoreduction, the emission maximum is shifted to 675 nm within 5 s. This result suggests that in young leaves, chlorophyllide formed after one flash is quickly released from the active site of NADPH: protochlorophyllide oxidoreductase. This interpretation is strenghtened by time-resolved fluorescence measurements at room temperature, showing that 675 nm emitting chlorophyllide does not transfer excitation energy to the 696 nm emitting chlorophyllide which is formed in very low amount. In 10-d-old bean leaves, the 690 nm chlorophyllide emitting species formed after one short flash undergoes the well-known rapid and Shibata spectral shifts. The 675 nm emitting chlorophyllide appears only as a shoulder. At both ages, the fluorescence intensity of the active protochlorophyllide strongly decreases during and after photoreduction, suggesting rapid modifications in the close environment of the pigment. [less ▲]

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See detailBiological control of postharvest Botrytis cinerea and Penicillium on apples
Jijakli, Haissam ULg; Lepoivre, Philippe ULg

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (1993), (16), 106-110

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See detailUtilisation d'un S.I.G. pour la gestion des ressources forestières : exemple d'application à un inventaire forestier régional
Lejeune, Philippe ULg; Lecomte, Hugues; Prevot, Hugues ULg

in Bulletin des Recherches Agronomiques de Gembloux (1993), 28(2-3), 275-286

The development of a Geographic Information System (G.I.S.) leads to new prospects in the field of broad-scale forest inventory, the main objective being to estimate areas and growing stock for the ... [more ▼]

The development of a Geographic Information System (G.I.S.) leads to new prospects in the field of broad-scale forest inventory, the main objective being to estimate areas and growing stock for the different stand types in a given region. The dot grid method typically used to estimate the areas in the case of systematic sampling, can be advantageously replaced by the creation within a G.I.S., of a stand map, that can be overlaid with data issued from the inventory. A methodology is proposed, to produce such a map using color infrared aerial photos at a scale of 1:25,000. Geographical data are processed using ILWIS software. The method has been tested on a 200 km² forest area. The error rate for interpretation of stand types is less than 6 % if one considers the confusions between species. The crossing of this stand map with the sample plots layer provides an estimation of the growing stock per stand type. [less ▲]

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See detailAspects cliniques de la néoplasie endocrinienne multiple de type 1 (NEM-1)
Ghuysen, Alexandre ULg; Beckers, Albert ULg; Stevenaert, Achille ULg

in Médecine & Chirurgie Digestives (1993), 22(8), 468-470

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See detailA comparative study of class-D beta-lactamases.
Ledent, Philippe; Raquet, X; Joris, Bernard ULg et al

in Biochemical Journal (1993), 292 ( Pt 2)

Three class-D beta-lactamases (OXA2, OXA1 and PSE2) were produced and purified to protein homogeneity. 6 beta-Iodopenicillanate inactivated the OXA2 enzyme without detectable turnover. Labelling of the ... [more ▼]

Three class-D beta-lactamases (OXA2, OXA1 and PSE2) were produced and purified to protein homogeneity. 6 beta-Iodopenicillanate inactivated the OXA2 enzyme without detectable turnover. Labelling of the same beta-lactamase with 6 beta-iodo[3H]penicillanate allowed the identification of Ser-70 as the active-site serine residue. In agreement with previous reports, the apparent M(r) of the OXA2 enzyme as determined by molecular-sieve filtration, was significantly higher than that deduced from the gene sequence, but this was not due to an equilibrium between a monomer and a dimer. The heterogeneity of the OXA2 beta-lactamase on ion-exchange chromatography contrasted with the similarity of the catalytic properties of the various forms. A first overview of the enzymic properties of the three 'oxacillinases' is presented. With the OXA2 enzyme, 'burst' kinetics, implying branched pathways, seemed to prevail with many substrates. [less ▲]

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See detailVisualizing the evolution of a star on a graphic workstation
Noels-Grötsch, Arlette ULg; Papy, Roland; Remy, F.

in Computers in Physics (1993), 7(2), 202-207

Theoretical models of a one solar mass star from the gravitational contraction onto the main sequence of the Hertzsprung-Russell diagram are visualized on a Tektronix 4337 workstation.

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See detailNormal Electro- and Vectorcardiographic Data in the Growing Friesian Calf Using a Semi-Orthogonal Lead System
Amory, Hélène ULg; Genicot, B; Rollin, Frédéric ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1993), 40(2), 81-92

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were ... [more ▼]

This study derives normal values for electro- and vectorcardiographic parameters, as generated by the Holmes semi-orthogonal lead system, in healthy growing calves. Sixty-four electrocardiograms were recorded from healthy Friesian calves aged from one week to one year. Waveform and duration were analysed and compared in the X-, Y- and Z-leads. The modal P, QRS and T tridimensional vectors were graphically constructed and their magnitude and orientation were calculated. The duration of waves and intervals were similar to data previously reported in the bovine species. Differences from data reported in other species were attributed to heart rate. The duration of waves and QT and ST intervals significantly lengthened with the decrease in heart rate which occurred during growth. PR interval significantly lengthened with physical maturation, and this change was independent of the decrease in heart rate. The magnitude and the orientation of the spatial modal vectors were approximately similar to the few data previously reported in cattle and in other ungulates and were not affected by somatic growth [less ▲]

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See detailStimulation of the 92-Kd Type Iv Collagenase Promoter and Enzyme Expression in Human Melanoma Cells
Lauricella-Lefebvre, M. A.; Castronovo, Vincenzo ULg; Sato, H. et al

in Invasion & Metastasis (1993), 13(6), 289-300

The 92-kD type IV collagenase is a member of the metalloproteinase family which degrades type IV collagen, a major component of basement membrane and is involved in tumor invasion and metastasis. The ... [more ▼]

The 92-kD type IV collagenase is a member of the metalloproteinase family which degrades type IV collagen, a major component of basement membrane and is involved in tumor invasion and metastasis. The promoter and adjacent regulatory sequences of the 92-kD type IV collagenase have been identified previously and three cis-acting elements homologous to the binding sites for AP-1, NF-KB and SP-1 proteins contributed to induction of the promoter activity by 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumor necrosis factor (TNF-alpha) in HT1080 cells. To date, no direct correlation between promoter activity and expression of the 92-kD type IV collagenase has been reported in normal or cancer cells. In this study, the effects of the transcriptional stimulation of the 92-kD type IV collagenase gene on the expression of the enzyme in human A2058 melanoma cells was analyzed by zymography experiments. Quantitative immunoblots using a monoclonal antibody that recognized specifically and exclusively the 92-kD type IV collagenase, confirmed that the 92-kD gelatinase was 92-kD type IV collagenase. Stimulation of the promoter activity resulted in increased gelatinase activity in the culture medium of A2058 cells. A direct correlation between TPA- and TNF-alpha-mediated promoter stimulation of the 92-kD type IV collagenase gene and its expression was also demonstrated in the human fibrosarcoma HT1080 cells. Interleukin-1 alpha failed to induce 92-kD gene promoter activity and type IV collagenase expression in melanoma and fibrosarcoma cell lines. Our data demonstrated that TPA- and TNF-alpha-induced 92-kD type IV collagenase promoter stimulation leads to a proportional increase of enzyme expression and secretion and thus could contribute to the activation of the invasive phenotype. [less ▲]

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See detailSTUDY OF THE CRYSTALLIZATION PROCESS IN BI2-XPBXSR2CA2CU3O10-Y GLASS SYSTEMS - OPTICAL POLARIZED-LIGHT MICROSCOPY, ELECTRICAL AND MAGNETIC-PROPERTIES
Cloots, Rudi ULg; Romain, Anne-Claude ULg; Rulmont, André ULg et al

in Superconductor Science & Technology (1993), 6(12), 850-857

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C ... [more ▼]

Synthesis of Bi2-xPbxSr2Ca2Cu3O10-y (x = 0 and x = 0.3) has been performed using the glass recrystallization route technique. After splat quenching, the samples were annealed at 820, 850 or 870-degrees-C for 96 or 144 h (with one intermediary grinding). High-resolution polarization micrographs and electrical (and magnetic susceptibility) measurements have been taken. Various growth mechanisms can thus be checked, and the physical properties are studied in relation to the microstructure. It is found that the 2223 phase does not crystallize directly from the amorphous one but results from a dissolution-reprecipitation process. The stability of the 2212 phase is emphasized. The 2201 phase precipitates at high temperature and rapidly reacts with the melt to form the 2223 phase. The kinetics of the lead-substituted sample seems to be controlled by the Ca2PbO4 phase. which acts as a flux. [less ▲]

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See detailCalcitonins: Newer Routes of Delivery
Reginster, Jean-Yves ULg

in Osteoporosis International : A Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis & the National Osteoporosis Foundation of the USA (1993), 3(Suppl 2), 3-7

Because of its anti-osteoclastic and analgesic properties, calcitonin is a first-line choice in the treatment of several bone diseases characterized by absolute or relative bone resorption. With regard to ... [more ▼]

Because of its anti-osteoclastic and analgesic properties, calcitonin is a first-line choice in the treatment of several bone diseases characterized by absolute or relative bone resorption. With regard to the prevention and treatment of postmenopausal osteoporosis, the chronic nature of the disease and the subsequent long duration of the pharmacological intervention require uncomfortable parenteral administration to be repeated on a long-term basis. Newer routes of administration have therefore been developed. At present the most promising of these are the nasal spray and the rectal suppository. Both routes have been shown to induce significant increases in plasma levels of salmon calcitonin. The ability of salmon calcitonin to cross the nasal mucosa was shown immunologically by the generation of specific anti-salmon-calcitonin antibodies in the plasma. In healthy volunteers these alternative routes of administration do not decrease the anti-osteoclastic activity of calcitonin, as demonstrated by a significant decrease in biochemical parameters that reflect bone turnover. In the prevention and treatment of postmenopausal osteoporosis, as well as in the treatment of Paget's disease of bone, the properties of calcitonins are generally preserved if they are administered non-parenterally. However, the equivalent doses required to sustain the effects of calcitonin have not been fully elucidated. This article reviews the potential benefits of two methods of non-parenteral administration of calcitonins in the prevention and treatment of postmenopausal osteoporosis. [less ▲]

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See detailReplacing the (beta alpha)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme
Mainfroid, Véronique; Goraj, Karine; Rentier-Delrue, Françoise ULg et al

in Protein Engineering (1993), 6(8), 893-900

In order to investigate how structural modifications interfere with protein stability, we modified a (beta alpha)-unit in E.coli triosephosphate isomerase (TIM), a typical (beta alpha)-barrel protein ... [more ▼]

In order to investigate how structural modifications interfere with protein stability, we modified a (beta alpha)-unit in E.coli triosephosphate isomerase (TIM), a typical (beta alpha)-barrel protein, assuming that the pseudosymmetrical beta-barrel can be divided into eight successive loop/beta-strand/loop/alpha-helix motifs. We replaced the eighth (beta alpha)-unit of E.coli TIM with the corresponding chicken (beta alpha)-unit. The substitution, involving the replacement of 10 of the 23 residues of this (beta alpha)-unit, was evaluated first by modelling, then experimentally. Modelling by homology suggests how the amino acid replacements might be accommodated in the hybrid E.coli/chicken TIM (ETIM8CHI). Both natural and hybrid recombinant TIMs, overproduced in E.coli, were purified to homogeneity and characterized as to their stability and kinetics. Our kinetic studies show that the modification performed here leads to an active enzyme. The stability studies indicate that the stability of ETIM8CHI is comparable to that of the wild type TIM. [less ▲]

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See detailLes méthodes d'analyse factorielle : principes et applications
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1993), 1

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements ... [more ▼]

This note describes in a simply way the principles of the factorial methods, and more particularly of the principal component analysis and the correspondence analysis. The emphasis is put on elements useful when interpreting the results of an analysis and the methods are illustrated by completely worked out examples. [less ▲]

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See detailTextual Space in Un chien Andalou
Drummond, Philippe; Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1993), 33-35

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See detailAérosolthérapie chez le cheval : 2. Etude pharmacologique
Lekeux, Pierre ULg; Genicot, Bruno; Votion, Dominique ULg et al

in Pratique Vétérinaire Equine (1993), 25(4), 233-243

This review analyzes the different therapeutic drugs the functional effects of which can be useful in the treatment by aerosol of equine respiratory disorders

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See detailUltrastructural distribution of DNA within the nucleolus of various animal cell lines or tissues revealed by terminal deoxynucleotidyl transferase.
Thiry, Marc ULg; Ploton, D.; Menager, M. et al

in Cell & Tissue Research (1993), 271(1), 33-45

We have used the highly sensitive in situ terminal deoxynucleotidyl transferase method, applied to ultrathin sections, to investigate the location of DNA within nucleoli of various animal cells. In all ... [more ▼]

We have used the highly sensitive in situ terminal deoxynucleotidyl transferase method, applied to ultrathin sections, to investigate the location of DNA within nucleoli of various animal cells. In all the nucleoli studied, intense labelling is revealed over the peri- and intranucleolar condensed chromatin. Gold particles are also consistently found over the fibrillar centres, especially at their periphery, namely in the border area between the fibrillar centres and the dense fibrillar component, whereas the dense fibrillar component itself seems to be free of label in nucleoli in which these two compartments can be distinguished. We conclude that, in transcriptionally active nucleoli of this type, DNA is a characteristic constituent of the fibrillar centres, distinguishing them functionally from the dense fibrillar component. Some nucleoli exhibit neither fibrillar centres nor a dense fibrillar component, but have a single, albeit heterogeneous accumulation of fibrillar material; gold particles are consistently seen over some parts of this fibrillar compartment. This suggests that certain parts of the fibrillar material are functionally similar to the fibrillar centres of those nucleoli that possess them. [less ▲]

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See detailPENICILLIN-BINDING PROTEIN 2X OF STREPTOCOCCUS-PNEUMONIAE - ENZYMATIC-ACTIVITIES AND INTERACTIONS WITH BETA-LACTAMS
JAMIN, M.; Damblon, Christian ULg; MILLIER, S. et al

in Biochemical Journal (1993), 292(Part 3), 735-741

The high-molecular-mass penicillin-binding protein (PBP) 2x, one of the primary targets of beta-lactam antibiotics in Streptococcus pneumoniae, has been produced as a soluble form and purified in large ... [more ▼]

The high-molecular-mass penicillin-binding protein (PBP) 2x, one of the primary targets of beta-lactam antibiotics in Streptococcus pneumoniae, has been produced as a soluble form and purified in large amounts. It has been shown to catalyse hydrolysis and transfer reactions with different ester and thiolester substrates and its catalytic behaviour was often similar to that of the soluble DD-peptidase from Streptomyces R61. This provided an easy method to monitor the activity of the PBP. For the first time, a reliable kinetic study of the interaction between a lethal target and beta-lactam antibiotics has been performed. Characteristic kinetic parameters were obtained with different beta-lactam compounds. These results not only validated the mechanism established with non-essential extracellular enzymes, but will also constitute the basis for comparative studies of the low-affinity variants from penicillin-resistant strains. [less ▲]

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See detailLa cinétique cellulaire tumorale: aspects cliniques «à la recherche du temps perdu»
Coucke, Philippe ULg; Paschoud, N

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (1993), 80(4), 431-437

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See detailHEXAGONAL MARANGONI CONVECTION IN A RECTANGULAR BOX WITH SLIPPERY WALLS
Dauby, Pierre ULg; Lebon, Georgy ULg; COLINET, P. et al

in Quarterly Journal Of Mechanics And Applied Mathematics (1993), 46(Part 4), 683-707

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See detailNo significant effect of an "atraumatic" needle on incidence of post-lumbar puncture headache or traumatic tap.
Lenaerts, M.; Pepin, J. L.; Tombu, S. et al

in Cephalalgia : An International Journal of Headache (1993), 13(4), 296-7

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients ... [more ▼]

We compared the incidence of post-lumbar puncture headache and of red blood cells in the first CSF sample (traumatic tap) in 35 inpatients punctured with a standard 20 G Yale needle and in 26 patients punctured with Sprotte's "atraumatic" needle. No significant difference was found between the two groups in incidence of headache or in frequency of traumatic taps. [less ▲]

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See detailFollicular Dendritic Cells Do Not Produce Tnf-Alpha nor its Receptor
Mancini, I.; Bosseloir, A.; Hooghe-Peters, E. et al

in Advances in Experimental Medicine and Biology (1993), 329

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See detailLa place de la radiothérapie dans le traitement des sarcomes des tissus mous
Coucke, Philippe ULg; Guillemin, C-L

in Bulletin du Cancer. Radiothérapie : Journal de la Société Française du Cancer : Organe de la Société Française de Radiothérapie Oncologique (1993), 80(1), 13-26

La radiothérapie des sarcomes des tissus mous est revue à travers la littérature. Comme la chirurgie, le traitement actinique fait partie du traitement standard. Comparée à la radiothérapie postopératoire ... [more ▼]

La radiothérapie des sarcomes des tissus mous est revue à travers la littérature. Comme la chirurgie, le traitement actinique fait partie du traitement standard. Comparée à la radiothérapie postopératoire, l'approche préopératoire et/ou interstitielle offre l'avantage potentiel de nécessiter de façon plus systématique une approche multidisciplinaire ab initio. Par ailleurs, la radiothérapie préopératoire implique une irradiation des tissus sains moins importante et donc une réduction probable de la toxicité. Le contrôle local et la survie sont comparables pour les deux modalités radiothérapeutiques. Toutefois, la comparaison entre différentes séries reste ardue vu l'hétérogénéité des populations étudiées. Une solution serait d'effectuer une étude randomisée [less ▲]

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See detailRapport préliminaire sur la 2e campagne de fouille à Tell Amarna (Syrie)
Tunca, Önhan ULg

in Akkadica (1993), 83

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See detailThe fractal nature of the power spectrum as an indicator of chaos in the Bianchi-IX cosmological model
Demaret, Jacques; De Rop, Yves ULg

in Physics Letters B (1993), 299(3-4), 223-228

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre ... [more ▼]

Using two different methods, we compute the fractal dimension of the power spectrum associated with numerical solutions of the spatially homogeneous Bianchi IX cosmological model in Misner-Chitre coordinates. According to Perdang's criterion, the noninteger character of this dimension is reflection of chaos and can be used to measure it, in the same spirit as the Lyapunov exponent of the Kolmogorov entropy. The results obtained indicate the chaotic nature of the behaviour of the Bianchi IX model near the cosmological singularity. [less ▲]

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See detaila new way to solve galloping on bundled lines. A concept, a prototype bytwo years field experience.
Lilien, Jean-Louis ULg; pirotte, pol; smart, Tom et al

in Bulletin Scientifique de l'Association des Ingénieurs Electriciens sortis de l'Institut Electrotechnique Montefiore (1993), 2

that paper introduce a new concept to control galloping on bundle conductors using a dynamic device coupling detuning of frequencies together with some addition in torsional damping.The concept is ... [more ▼]

that paper introduce a new concept to control galloping on bundle conductors using a dynamic device coupling detuning of frequencies together with some addition in torsional damping.The concept is explained, a prototype is tested on actual line and results are presented. [less ▲]

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See detailÉvolution et fréquence des inondations de l'Ourthe inférieure.
Pauquet, A.; Petit, François ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1993)

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See detailRéussite de quatre nichées successives chez le martin pêcheur d'Europe (Alcedo atthis) au cours de la même saison
Libois, Roland ULg

in Aves (1993), 30(1), 31-36

From 1985 to 1992, 229 breeding pairs of kingfisher were studied to determine the reproduction success and the way population recovered after the severe winter 1984-85. From these investigations, we were ... [more ▼]

From 1985 to 1992, 229 breeding pairs of kingfisher were studied to determine the reproduction success and the way population recovered after the severe winter 1984-85. From these investigations, we were able to observe four successive nesting attempts by five different pairs. Four broods were raised by one of the pairs. As the adult were ringed birds and were regularky checked throughout the breeding season, ther can be no doubt, now, as to the possibility of a fourth brood for this species, at least in peculiar circumstances. [less ▲]

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See detailUne logique de l'anorexie mentale
Servais, Véronique ULg

in Revue Internationale de Systémique (1993), 7(4), 385-418

The paper presents a batesonian approach of anorexia nervosa. The illness is viewed as a positive feedback loop. The first restrictions appear as a solution to diverse problems of adolescence. Then the ... [more ▼]

The paper presents a batesonian approach of anorexia nervosa. The illness is viewed as a positive feedback loop. The first restrictions appear as a solution to diverse problems of adolescence. Then the restrictions become a deutero-learning : the girl finds pleasure and security in restriction behaviours. She si permanently looking for challenging contexts where she can proof her self control. Because the control is a deutero-learning the behavior cannot be diminished through punishment. Only the restoration of relationships with the whole personnality and the environment can give the girl the therapeutic experience of becoming to as system that she cannot control. [less ▲]

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See detailDecision tree approaches to voltage security assessment
Van Cutsem, Thierry ULg; Wehenkel, Louis ULg; Pavella, Mania ULg et al

in IEE Proceedings - Generation, Transmission & Distribution (1993), 140

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See detailStructure, function and assembly of the nucleolus.
Scheer, U.; Thiry, Marc ULg; Goessens, Guy ULg

in Trends in Cell Biology (1993), 3(7), 236-41

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins ... [more ▼]

Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis. [less ▲]

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See detailCarbohydrate-deficient glycoprotein syndrome type II.
Jaeken, J.; De Cock, P.; Stibler, H. et al

in Journal of inherited metabolic disease (1993), 16(6), 1041

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See detailLes chimpanzés : un modèle animal de la relation clientélaire
Servais, Véronique ULg

in Terrain (1993), 21(octobre), 67-80

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable ... [more ▼]

The paper is about the dominance and coalition relationship among male chimpanzees. It focuses on the dependance relationship between the members of the coalition and distinguishes stable and unstable coalitions. A coalition is unstable if the support of the dominated individual is conditional and stable if it is not (i.e. among two brothers). In an unstable coalition the dominated indivuual can afford some priviledge, the dominant is very dependent on the subordinate and the relationship with the dominant is tense. Analogies with human power relationships are suggested. [less ▲]

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See detailAssociation of Aortic Stenosis and Gastrointestinal Bleeding (Heyde's Syndrome). Report of Two Cases
Natowitz, L.; DEFRAIGNE, Jean ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1993), 93(1), 31-3

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent ... [more ▼]

The association between aortic stenosis and digestive angiodysplasia has been described for the first time by Heyde in 1958. This entity is thus known as Heyde's syndrome. In many instances, the recurrent small intestinal bleeding originating from angiodysplasia stopped after aortic valve replacement. We report two cases of patients presenting with a recurrent small intestinal bleeding originating from digestive angiodysplasia and suffering from aortic stenosis. Diagnosis of both pathologies is well documented in both cases. The replacement of the aortic valve by a biologic prosthesis stopped the bleeding. Prior to aortic valve replacement, the two patients suffered severe recurrent blood loss from intestinal angiodysplasia. The treatment of aortic stenosis greatly favored both cardiac and general status. We recommend aortic valve replacement with a biologic prosthesis prior to intestinal resection in patients presenting with Heyde's syndrome. We stress on the fact that anticoagulants must be stopped in order to minimize the risk of further bleeding. [less ▲]

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See detailIntracellular damages induced by singlet oxygen are signals for HIV-1 reactivation
Piette, Jacques ULg; Legrand-Poels, Sylvie ULg

in Journal of Free Radicals in Biology & Medicine (1993)

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See detailLaparoscopic surgery, urology and gynaecology
Joris, Jean ULg

in Current Opinion in Anaesthesiology (1993), 6

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See detailBeam-laser lifetime measurements for low-lying levels in Cr II
Pinnington, E. H.; Ji, Q.; Guo, B. et al

in Canadian Journal of Physics (1993), 71

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See detailBPDZ 44: a new and potent activator of ATP-sensitive K+ channels
Lebrun, P.; Pirotte, Bernard ULg; Antoine, M.-H. et al

in Diabetologia (1993), 36

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See detailSynthesis and Inverse Emulsion Polymerization of Aminated Acrylamidodextran
Daubresse, Catherine; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Pharmacy & Pharmacology (1993), 45

A chemically modified form of dextran was prepared; having a polymerizable moiety (acrylamide) and a reactive functional group (primary amine). Dextran was activated with 4-nitrophenylchloroformate (24 ... [more ▼]

A chemically modified form of dextran was prepared; having a polymerizable moiety (acrylamide) and a reactive functional group (primary amine). Dextran was activated with 4-nitrophenylchloroformate (24 mol per polysaccharide, 9,8 mol per 100 glucose residues); 9,8% glucose residues were converted to aliphatic carbonates and 5,2% were converted to cyclic carbonates. The activated dextran was coupled with trityldiaminoethane (8 mol per 100 glucose residues), reactivated with 4-nitrophenylchloroformate, then coupled with acryloamidodiaminohexane (6,8 mol per 100 glucose residues). The trityl group was removed by hydrolysis with trifluoroacetic acid to yield the required aminated acryloamidodextran. The modified dextran was shown to be polymerizable by inverse emulsion polymerization. Submicron particules were successfully prepared, containing functional amine groups suitable for preparing drug conjugates or for modifying the surface properties of thisbiomaterial. [less ▲]

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See detailLe récepteur NMDA : base moléculaire du mécanisme d’action de la kétamine
Hanon, E.; Gustin, Pascal ULg; Ansay, M.

in Annales de Médecine Vétérinaire (1993), 137

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See detailAccurate f-values of Astrophysical Interest in neutral Carbon
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Astronomy and Astrophysics. Supplement Series (1993), 99

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See detailBiphasic locomotor effects of the dopamine D-sub-1 agonist SKF 38393 and their attenuation in non-habituated mice
Tirelli, Ezio ULg; Terry, P.

in Psychopharmacology (1993), 110(1-2), 69-75

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously ... [more ▼]

Examined the locomotor stimulatory effects of the dopamine D-sub-1 receptor partial agonist SKF 38393 in male C57B1/6J mice. Non-habituated mice showed marked dose-related (3-300 mg/kg, subcutaneously) locomotor stimulation. The time-course effect was biphasic at very high doses (100-300 mg/kg), with dose-related locomotor depression followed by dose-related long-term hyperlocomotion. For all doses, locomotor effects were detectable throughout the 4-hr test period. To determine whether these effects were mediated by D-sub-1 receptor stimulation, effects of SKF 38393 were assessed in combination with behaviorally inactive and active doses (0.1 and 0.2 mg/kg, respectively) of the selective D-sub-1 receptor antagonist SCH 39166. Both doses of SCH 39166 attenuated the hyperlocomotion induced by 30 mg/kg of the agonist to a similar degree. However, neither dose was able to reverse either the depressant or the stimulatory effects of 300 mg/kg SKF 38393. ((c) 1997 APA/PsycINFO, all rights reserved) [less ▲]

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See detailCompte rendu de "Papier blanc, encre noire"
Defays, Jean-Marc ULg

in Bulletin Francophone de Finlande (1993), (9), 1-3

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See detailUsing Partial Orders for the Efficient Verification of Deadlock Freedom and Safety Properties
Godefroid, Patrice; Wolper, Pierre ULg

in Formal Methods in System Design (1993), 2(2), 149--164

This article presents an algorithm for detecting deadlocks in concurrent finite-state systems without incurring most of the state explosion due to the modeling of concurrency by interleaving. For systems ... [more ▼]

This article presents an algorithm for detecting deadlocks in concurrent finite-state systems without incurring most of the state explosion due to the modeling of concurrency by interleaving. For systems that have a high level of concurrency, our algorithm can be much more efficient than the classical exploration of the whole state space. Finally, we show that our algorithm can also be used for verifying arbitrary safety properties. [less ▲]

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See detailPolarization correction of the electrostatic potential for aromatic-compounds - Study of the nucleophilic-attack
Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1993), 46(1), 127-136

The electrostatic potential (EP) and the polarization correction (PL) on the EP were calculated for four aromatic compounds: benzene, chlorobenzene, phenol, and benzoic amide, at the ab initio SCF level ... [more ▼]

The electrostatic potential (EP) and the polarization correction (PL) on the EP were calculated for four aromatic compounds: benzene, chlorobenzene, phenol, and benzoic amide, at the ab initio SCF level within two basis sets: 6-31G** and MINI-1. One calculation was performed using the polarized MINI-1** basis set. The quantity total interaction energy (TEH) defined as -EP + PL can be used as an indicator of the nucleophilic attack preferential position. By reference to 6-31G**, MINI-I provides very satisfactory results. Moreover, the MINI-1** results are very similar to the MINI-I ones. It appears that -EP does not provide a reliable tool to study the nucleophilic attack susceptibility, whereas TEH seems to be very well adapted for this kind of approach. [less ▲]

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See detailPhysiological response to the cross country phase in eventing horses
Amory, Hélène ULg; Art, Tatiana ULg; Linden, Annick ULg et al

in Journal of Equine Veterinary Science (1993), 13

Blood samples were collected for lactate concentration determination (Lacc) at the arrival of the cross-country phase from 40 horses of various class levels competing in 6 different three-day events ... [more ▼]

Blood samples were collected for lactate concentration determination (Lacc) at the arrival of the cross-country phase from 40 horses of various class levels competing in 6 different three-day events. Moreover, in 8 horses, heart rate (HR) was recorded every 5 seconds during the cross-country. Among them, 5 horses were submitted, at the beginning of the competition's season to a standardized exercise test (SET) on a track which allowed us to study the relationship between HR, blood lactate concentration and running speed on flat ground in these horses. The relationship between mean HR and mean speed, between Lacc and mean speed and between Lacc and HR during the cross-country were studied using regression analysis. Mean HR during the cross-country was linearly related to mean speed during this phase (r=0.87, p ≤ 0.01), but this relationship was shifted upwards in comparison with the corresponding curve obtained during the SET (r=0.97, p ≤ 0.001). In the same way, the relationship between Lacc and mean speed during the cross-country was exponential (r=0.93, p ≤ 0.001), but blood lactate accumulation occurred at a lower speed than during the SET (r=0.94, p ≤ 0.001). The correlation between Lacc and HR was stronger when Lacc was related to HR during the 15 last minutes of the cross (r = 0.84) than to mean HR during the whole cross (r = 0.75) or to HR during the 2 last (r = 0.74) or the last (r = 0.80) minute of the course, which indicated that continuous recording of HR allowed a more accurate estimation of the severity of exercise performed during the cross-country than Lacc. Heart rate ranged from 170 to 190 beats/min during the first part of the cross-country and reached or exceeded values of 190 to 200 beats/min at the end of the course. Therefore, the anaerobic threshold is reached during cross-country. Recruitment of anaerobic me tabolism at the end of the course was otherwise demonstrated by the high values of Lacc. These aerobic-anaerobic meta bolic requirements should be taken into account to design the training program of an eventing horse. [less ▲]

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See detailControl of the illegal administration of natural steroid hormones in urine and tissues of veal calves and in plasma of bulls
Scippo, Marie-Louise ULg; Gaspar, Pol; Degand, Guy ULg et al

in Analytica Chimica Acta (1993), 275(1-2), 57-74

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See detailStructure des populations de renard roux, Vulpes vulpes, dans le sud de la Belgique en relation avec l'enzootie rabique et les campagnes de vaccination orale
AFIADEMANYO, Komlan; Libois, Roland ULg; Brochier, Bernard et al

in Cahiers d'Ethologie (1993), 13(3), 281-294

From 1989 to 1991, 549 fox carcasses were examined in oder to assess the impact of rabies control measures (oral vaccination with VVTGgRAB recombinant vaccinia-rabies virus). Their age was determined ... [more ▼]

From 1989 to 1991, 549 fox carcasses were examined in oder to assess the impact of rabies control measures (oral vaccination with VVTGgRAB recombinant vaccinia-rabies virus). Their age was determined using a lower canine tooth. The distinction between young and adults was made on radiographs, measuring the relative importance of the pulp cavity. Adult animals were aged by counting the annual growth cementum layers in tooth sections. The sex-ratio is in favour of the males and the age-pyramid is a large-base flattened one, with more than 60% of young (< 1 year) animals. Life expectancy at birth is 1.14 y. in the males and 1.23 y. in the females. The population turnover is quite high, the whole population being revewed in a 3-4 y. time interval. As far as the age structure is concerned, no difference has been found between males and females, rabid and sound animals, immunised or not. However, the spring vaccination campaign is much less efficient for the young foxes. These results suggest that rabies affects indistinctly all age classes of both sexes, just as it is the case with the autumn vacciation campaigns. Moreover, a comparison between the samples of two natural regions differing in their hunting system (big vs. small game) revealed no age structure difference suggesting that the high hunting pressure can explain better than rabies itself the very important juvenile prportion in the population. Nevertheless, some further research is needed to confirm that last point. [less ▲]

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See detailPhysiologie de la cellule enterochromaffin-like (ECL) dans la régulation de la sécrétion gastrique acide
Delwaide, Jean ULg; Belaiche, Jacques ULg; Latour, Pascale ULg

in Médecine & Chirurgie Digestives (1993), 22

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir ... [more ▼]

Cette mise au point rappellera d'abord les grands mécanismes de la sécrétion gastrique acide en insistant sur le rôle pivot de l'histamine. Une question qui demeurait encore non résolue était de savoir quelle était la cellule fundique qui produisait de l'histamine dans les conditions physiologiques. Deux cellules seront envisagées, les mastocytes et les cellules ECL qui sont des cellules endocrines exclusivement localisées dans le fundus. Quelques arguments seront développés, dont ceux provenant de notre expérience, permettant de penser que la cellule ECL contient de l'histamine. L'article se terminera par un essai d'intégration de la cellule ECL dans le schéma de la sécrétion gastrique acide en montrant son rôle essentiel potentiel. [less ▲]

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See detailThe OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p12-17p13 region of the human genome and reveals a MspI restriction fragment lenght polymorphism
Schurmans, Stéphane ULg; Muscatelli, F.; Miot, F. et al

in CytoGenetics & Cell Genetics (1993), 63

Olfactory receptors are believed to be encoded by an extremely large subfamily of G protein-coupled receptors. A human gene (OLFR1) encoding a member of this family was cloned from a genomic library by ... [more ▼]

Olfactory receptors are believed to be encoded by an extremely large subfamily of G protein-coupled receptors. A human gene (OLFR1) encoding a member of this family was cloned from a genomic library by cross-hybridization with a gene fragment obtained by the polymerase chain reaction. The nucleotide sequence of a 3.4-kb EcoRI fragment was determined, and the protein sequence was deduced from the single open reading frame. The gene was assigned by in situ hybridization of metaphase chromosomes to the 17p13-->p12 region of the human genome, in proximity to the tumor-suppressor gene encoding p53. When used as a probe on Southern blots under moderately stringent conditions, it hybridizes to at least three closely related genes. A restriction fragment length polymorphism was detected after MspI digestion. Mendelian segregation of the gene was assessed in three CEPH families, and linkage analysis confirmed the localization of the locus [less ▲]

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See detailQuantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin.
Beguin, Yves ULg; Clemons, G. K.; Pootrakul, P. et al

in Blood (1993), 81(4), 1067-76

We evaluated the quantitative value of a simple model of erythropoiesis, based on the basic assumptions that the red blood cell (RBC) mass determines erythropoietin (Epo) production, which in turn ... [more ▼]

We evaluated the quantitative value of a simple model of erythropoiesis, based on the basic assumptions that the red blood cell (RBC) mass determines erythropoietin (Epo) production, which in turn stimulates erythropoietic activity. The RBC mass was quantitated by direct isotopic measurement (RCM), Epo production by serum Epo levels, and erythropoiesis by the ferrokinetic measurement of the erythron transferrin uptake (ETU), the serum transferrin receptor (TfR) level, and the reticulocyte (retic) index, and was completed by an evaluation of overall marrow erythron cellularity. We studied a total of 195 subjects, including 31 normal individuals, 38 patients with polycythemia, and 126 patients with various forms of anemia. Instead of only quantitating Epo and erythropoiesis in absolute terms, we also evaluated them in relation to the degree of anemia or polycythemia, and expressed the results as a ratio of observed values to values predicted from the regression equations between hematocrit (Hct) on the one hand, and Epo, TfR, and ETU on the other, obtained in a carefully selected subpopulation. The slope of the regression of TfR (as well as ETU) versus Hct was very similar to the slope of the regression of Epo versus Hct. Average EPO and TfR (as well as ETU) values predicted from the regression equations were quite comparable to observed values in most groups of subjects, with exceptions predictable from knowledge of the pathophysiology of these hematologic disorders. We identified four major patterns of erythropoiesis, ie, normal, hyperdestruction (with variants of hemolysis or ineffective erythropoiesis), intrinsic marrow hypoproliferation, and defective Epo production. Dissecting out groups of patients showed much greater heterogeneity than when patients were analyzed by group. This was particularly true in the case of a hypoproliferative component being combined with hyperdestruction, giving what we called a "mixed disorder of erythropoiesis." We conclude that the pathophysiology of anemia can be assessed by a simple measurement of Hct, retic index, Epo, and TfR levels, with Epo and TfR being more informative when expressed in relation to the degree of anemia. The model is particularly useful for detecting the presence of multiple mechanisms of anemia in the same patient. However, it has limitations inherent to the relative invalidity of TfR in iron deficiency, the imprecision of a retic count, and the difficulty in distinguishing hemolysis from ineffective erythropoiesis in some patients and in recognizing a component of hyperdestruction in hypoproliferative anemia. [less ▲]

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See detailClonidine and ketanserin both are effective treatment for postanesthetic shivering.
Joris, Jean ULg; Banache, Maryse; Bonnet, Francis et al

in Anesthesiology (1993), 79(3), 532-9

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which ... [more ▼]

BACKGROUND: Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which shivering can be controlled. Accordingly, we investigated the efficacy of clonidine, an alpha 2-adrenergic agonist, and ketanserin, a 5-hydroxytryptamine antagonist, in treating postanesthetic shivering. METHODS: First, 54 patients shivering after general anesthesia were allocated randomly to receive an intravenous bolus of saline, 150 micrograms clonidine, or 10 mg ketanserin. A second study explored the dose-dependence of clonidine. Forty shivering patients were given saline or clonidine, 37.5, 75, or 150 micrograms. RESULTS: The duration of shivering was significantly shorter in those given clonidine (2.1 +/- 0.9 min) than in the other two groups and shorter in the ketanserin group (4.3 +/- 0.9 min) than in the saline group (12.0 +/- 1.6 min). Clonidine and ketanserin significantly decreased systolic arterial blood pressure when compared to saline. Core rewarming was significantly slower in the clonidine group. In the second study, 37.5 micrograms clonidine was no more effective than saline. Two minutes after treatment, 150 micrograms obliterated shivering in all patients. Five minutes after treatment, all patients given 75 micrograms had stopped shivering. Systolic arterial pressure and heart rate decreased significantly in patients given 75 and 150 micrograms clonidine. CONCLUSIONS: Clonidine (150 micrograms) and ketanserin (10 mg) both are effective treatment for postanesthetic shivering. The effect of clonidine on shivering is dose-dependent: whereas 37.5 micrograms had no effect, 75 micrograms clonidine stopped shivering within 5 min. [less ▲]

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See detailn < 2 Allowed Transitions in Neutral Sulfur within in the Visible and Infrared Spectral Ranges
Biémont, Emile ULg; Quinet, Pascal ULg; Zeippen, C. J.

in Astronomy and Astrophysics. Supplement Series (1993), 102

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See detailPotentialités de modulation de la réaction inflammatoire
Delannoy, I.; Miossec, P.; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1993), 137

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See detailSell-Off en de welvaart van aandeelhouders
Corhay, Albert ULg; Tourani-Rad, Alireza

in Maandblad voor Accountancy en Bedrijfseconomie [=MAB] (1993), 67(10), 471-477

In het kader van de herstructurering van het Nederlandse bedrijfsleven vindt de laatste jaren een groot aantal Sell-Offs plaats. Theoretici betogen dat een Sell-Off een aantal voordelen voor het ... [more ▼]

In het kader van de herstructurering van het Nederlandse bedrijfsleven vindt de laatste jaren een groot aantal Sell-Offs plaats. Theoretici betogen dat een Sell-Off een aantal voordelen voor het afstotende moederbedrijf oplevert. Blijkens deze studie ondersteunt het empirische onderzoek de theorie. In Nederland lijken significante buitengewone positieve koerseffecten op de dag van aankondiging voor de aandeelhouders van de verkopende bedrijven met dit soort transacties gepaard te gaan. Tevens is vastgesteld dat de aard van de aankondiging en de bekendmaking van het motief voor de Sell-Off positieve significante invloed heeft op de grootte van het buitengewoon rendement. Ten slotte is geconcludeerd dat alleen in het geval van buiten Nederland gevestigde dochters sprake is van een positief significant rendement [less ▲]

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See detailGrowth hormone-binding proteins (GH-BPs) and milk production in cattle
Massart, Serge; Renaville, Robert ULg; Prandi, Alberto et al

in Journal of Animal Science (1993), 71(suppl 1), 228

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See detailCommon stochastic trends in European stock markets
Corhay, Albert ULg; Tourani-Rad, Alireza; Urbain, Jean-Pierre ULg

in Economics Letters (1993), 42(4), 385-390

The objective of the paper is to investigate whether price indices of different European stock markets display a common long-run trending behaviour. Using cointegration analysis, we provide empirical ... [more ▼]

The objective of the paper is to investigate whether price indices of different European stock markets display a common long-run trending behaviour. Using cointegration analysis, we provide empirical evidence of common stochastic trends among five important European stock markets over the period 1975-1991. [less ▲]

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See detailEarly prediction of response to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen.
Beguin, Yves ULg; Loo, Martine; R'Zik, Samir ULg et al

in Blood (1993), 82(7), 2010-6

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anemia of chronic renal failure, but the dose needed may be variable. The reason for this variation is not known ... [more ▼]

Recombinant human erythropoietin (rHuEpo) has been shown to be effective in correcting the anemia of chronic renal failure, but the dose needed may be variable. The reason for this variation is not known, but several factors could be involved, such as iron deficiency, inflammation, aluminum intoxication, hyperparathyroidism, blood losses, or marrow dysfunction. Treatment with rHuEpo was given intravenously thrice weekly after hemodialysis to 64 consecutive unselected patients with the anemia of chronic renal failure. The starting dose was 50 U/kg/dose, which was increased to 75 and 100 U/kg/dose if no response was observed after 1 and 2 months of treatment. After a minimum follow-up of 6 months, response was evaluated as early (hematocrit [Hct] > or = 30% before 3 months) or late (Hct > or = 30% after 3 months) response, or failure (target Hct not attained). We examined the value of various laboratory parameters (baseline values and early changes) as predictors of response to rHuEpo. The best prediction by pretreatment parameters only was obtained with baseline serum transferrin receptor (TfR) (< or > or = 3,500 ng/mL) and fibrinogen (< or > or = 4 g/L): 100% response rate when both parameters were low, versus only 29% when they were both high, and versus 67% when one was low and the other high. When the 2-week TfR increment was greater than 20%, the response rate was 96%. When TfR increment was less than 20%, the response rate was 100% when baseline TfR and fibrinogen were low, 12% when fibrinogen was elevated, and 62% when fibrinogen was low but baseline TfR high. The predictive value of baseline TfR and fibrinogen and of the 2-week increment of TfR was confirmed by life table analysis and stepwise discriminant analysis. Major reasons for failure or late response were identified and included subclinical inflammation, iron deficiency, functional iron deficiency, marrow disorders, hemolysis, bleeding, and low Epo dose. We conclude that response to rHuEpo can be predicted early by pretreatment fibrinogen and TfR, together with early changes of TfR levels. These prognostic factors illustrate the importance of the early erythropoietic response, subclinical inflammation, and functional iron deficiency. Early recognition of a low probability of response in a given patient could help identify and correct specific causes of treatment failure to hasten clinical improvement and avoid prolonged ineffective use of an expensive medication. [less ▲]

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See detailLaparoscopic myolysis with the Nd:YAG laser.
NISOLLE, Michelle ULg; Smets, Mireille; Malvaux, Vincent et al

in Journal of Gynecologic Surgery (1993), 9(2), 95-9

Laparoscopic myomectomy can be carried out in cases of subserosal and intramural fibroids. Laparoscopic myolysis can be proposed as an alternative to laparoscopic myomectomy in cases of large or multiple ... [more ▼]

Laparoscopic myomectomy can be carried out in cases of subserosal and intramural fibroids. Laparoscopic myolysis can be proposed as an alternative to laparoscopic myomectomy in cases of large or multiple intramural fibroids in women aged over 40 or not desiring to bear more children but wishing to avoid a future hysterectomy. The authors report the technique and the long-term results in a series of 48 women with fibroids treated by myolysis. Because of the risk of bowel adhesions, further studies with another type of laser fiber are required. [less ▲]

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See detailMourir à son postmoderne
Demoulin, Laurent ULg

in Ecritures (1993), 5

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à ... [more ▼]

Treize réflexions sur la notion de postmodernité, considérée étymologiquement, c'est-à-dire comme un "après" la modernité (et non comme un retour en arrière, ou une surmodernité). La postmodernité est à distinguer du postmodernisme (si celui-ci existe). [less ▲]

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See detailMicroencapsulation by Coacervation of Poly(lactide-co-glycolide)-II:Encapsulation of a Dispersed Aqueous Phase
Nihant, Nicole; Stassen, S; Grandfils, Christian ULg et al

in polymer International (1993), 32

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This ... [more ▼]

This paper is related to the phase separation of different copolyesters of lactides and glycolide solutions induced by the addition of silicone oil in order to promote microencapsulation of proteins. This coating process can be divided in three successive steps: phase separation of the coating polymer; adsorption of the coacervate droplets around the drugs phase, and microcapsule solidification. This paper focuses on the physico-chemical analysis of the second step. The knowledge of the interfacial tensions between the three liquid phases allows understanding of the microscopic evolution of the phase separation medium. [less ▲]

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See detailRadiative Lifetime Measurements in Dy II and the Solar Abundance of Dysprosium
Biémont, Emile ULg; Löwe, R. M.

in Astronomy and Astrophysics (1993), 273

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See detailEffects of dexamethasone treatment on growth performances, sexual axis and hormonal status in finishing bulls
Renaville, Robert ULg; Massart, Serge; Devolder, Anne et al

in Journal of Animal Science (1993), 71(suppl 1), 232

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See detailAspects cliniques de la neoplasie endocrinienne multiple de type 1 (NEM-1).
Ghuysen, Alexandre ULg; Stevenaert, Achille ULg; Beckers, Albert ULg

in Revue Médicale de Liège (1993), 48(6), 309-63

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See detailA method of comparison of two close batches data: Application to analysis of fog formation causes
Boreux, Jean-Jacques ULg; Guiot, Joël

in Geophysical Research Letters (1993), 20(12), 1179-1182

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs ... [more ▼]

Given suitable conditions of air temperature and humidity, the density of a fog and its microphysical properties depend mainly on the availability of cloud condensation nuclei (CCN) and their nature. Fogs become particularly dense near certain industrial plants because of high concentration of hygroscopic combustion particles in the air. Their role in dense fog formation is estimated by comparing the local climates and CCN concentrations at two similar sites, the first being more subject to air pollution and dense fogs than the second. Orthogonal regression is applied to three meteorological variables (air temperature, relative humidity, wind speed) and CCN concentration. As we compare very close variables, bootstrap provides precise confidence intervals independent of Gaussian assumptions. Two sites are compared: they are located in the Meuse valley (Belgium) at a distance of about 15 km. We found that the local climate of the polluted site is not only colder and wetter but also richer in CCN that the control site. These results suggest interactions of natural and anthropogenic causes in dense fog formation at industrial site. This method is useful in various domains of geophysics when correlated time series have to be compared. [less ▲]

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See detailTransmission, Recombination and Conversion of Mitochondrial Markers in Relation to the Mobility of a Group I Intron in Chlamydomonas
Remacle, Claire ULg; Matagne, René-Fernand ULg

in Current Genetics (1993), 23(5-6, May-Jun), 518-25

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs ... [more ▼]

Mitochondrial DNA transmission has been analyzed in diploids produced from sexual crosses or artificial fusions between Chlamydomonas strains which differ by several genetic markers: a group I intron (Cs cob. 1 or alpha intron), three restriction sites (Nh, Nc and H markers) located 0.5-5 kb from the insertion site of the intron, and a MUD2 point mutation (27 bp from the insertion site) conferring resistance to myxothiazol. Recombination between mitochondrial markers is a general property of all crosses and fusions analyzed. In crosses between two intron-containing (alpha+) strains or two intron-less (alpha-) strains, the transmission is preferentially paternal (mt-), with a preponderance depending on the nature of the parental genomes. In crosses between alpha+ and alpha- strains, the conversion of intron-less molecules intron+ is frequent when the alpha+ parent is maternal (mt+) and nearly absolute when the alpha+ parent is paternal (mt-). In 94% of cases, the conversion is accompanied by the co-conversion of the MUD2 marker. In both crosses and artificial fusions, the conversion of alpha- into alpha+ also influences the transmission of the more distant Nh, Nc and H markers. It is hypothesized that the more frequent transmission of the genome containing the intron results from the elimination of alpha- molecules, as a result of a double-strand cut which is induced by an endonuclease encoded by the intron. [less ▲]

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