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See detailImportance of the E-46-D-160 Polypeptide Segment of the Non-Penicillin-Binding Module for the Folding of the Low-Affinity, Multimodular Class B Penicillin-Binding Protein 5 of Enterococcus Hirae
Mollerach, Marta E.; Partoune, Pierre; Coyette, Jacques ULg et al

in Journal of Bacteriology (1996), 178(6), 1774-1775

Compared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin ... [more ▼]

Compared with the other class B multimodular penicillin- binding proteins (PBPs), the low-affinity PBP5 responsible for penicillin resistance in Enterococcus hirae R40, has an extended non-penicillin-binding module because of the presence of an approximately 110-amino-acid E-46(-)D-160 insert downstream from the membrane anchor. Expression of pbp5 genes lacking various parts of the insert-encoding region gives rise to proteins that are inert in terms of penicillin binding, showing that during folding of the PBP, the insert plays a role in the acquisition of a correct penicillin-binding configuration by the G-364(-)Q-678 carboxy-terminal module. [less ▲]

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See detailDifunctional initiator based on 1,3-diisopropenylbenzene. 2. Kinetics and mechanism of the sec-butyllithium/1,3-diisopropenylbenzne reaction
Yu, Y. S.; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecules (1996), 29(5), 1753-1761

Kinetics of the addition of s-butyllithium (s-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied, and the activation energy has been found to be 17.5 kcal/mol. Addition of s-BuLi to 1,3-DIB in a ... [more ▼]

Kinetics of the addition of s-butyllithium (s-BuLi) to 1,3-diisopropenylbenzene (1,3-DIB) has been studied, and the activation energy has been found to be 17.5 kcal/mol. Addition of s-BuLi to 1,3-DIB in a 2/1 molar ratio results in an oligomer rather than the desired diadduct. This observation has to be compared to the anionic polymerization of 1,3-DIB (hydrocarbon solvent at 50 °C) which leads to a polymer bearing ca. one double bond per monomeric unit. Li-NMR analysis of the addition of s-BuLi to 1,3-DIB (2/1 molar ratio) confirms the nonequivalence of the lithium cations and shows that ca. 30% s-BuLi remains unreacted when 1,3-DIB has been completely consumed. In the early stage of the addition, the propagation rate is faster than depropagation and the average molecular weight increases. When a depropagation−propagation quasi-equilibrium is reached, the oligomer molecular weight remains constant. It finally decreases when no DIB is left, as a result of depropagation. When the s-BuLi/1,3-DIB adduct is used as an initiator for styrene polymerization in the presence of a polar solvent, such as THF, initiation by monofuntional, difunctional, trifunctional, and tetrafunctional species is observed. In an apolar solvent, however, polystyrene of a narrow molecular weight distribution and a functionality of 2 is formed. This experimental observation more likely indicates that depolymerization of the 1,3-DIB oligomers occurs upon the addition of styrene. A mechanism which accounts for this propagation−depropagation process has been proposed and experimentally supported. [less ▲]

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See detailClONO2 total vertical column abundances above the Jungfraujoch Station, 1986-1994: Long-term trend and winter-spring enhancements
Rinsland, C. P.; Zander, Rodolphe ULg; Demoulin, Philippe ULg et al

in Journal of Geophysical Research (1996), 101(D2), 3891-3899

Total vertical column abundances of chlorine nitrate (ClONO2) have been retrieved from 0.006 cm(-1) resolution solar absorption spectra recorded at the International Scientific Station of the Jungfraujoch ... [more ▼]

Total vertical column abundances of chlorine nitrate (ClONO2) have been retrieved from 0.006 cm(-1) resolution solar absorption spectra recorded at the International Scientific Station of the Jungfraujoch (ISSJ) in the Swiss Alps (altitude 3.58 km, latitude 46.5 degrees N, longitude 8.0 degrees E) on 105 days between June 1986 and November 1994. The analysis is based on spectral fittings of the ClONO2 nu(4) band Q branch at 780.21 cm(-1) and the interferences occurring in the same spectral region. The ISSJ measurements show a regular long-term increase in the ClONO2 column with an occasional factor of 2 to 3 enhancements during the midwinter to early spring. Excluding data from this time of the year, the ISSJ database reflects a linear rate of increase and la uncertainty equal to (4.0 +/- 0.7)% yr(-1) referenced to 1990.0. The corresponding ClONO2 total vertical columns for mid-1986 and mid-1994 are equal to 0.92 and 1.26 x 10(15) molecules cm(-2), respectively. The high ClONO2 columns and high HF/HCl column ratios sometimes measured during winter indicate the occasional presence of chemically processed air above the station. This is corroborated by trajectories calculated for the stratospheric air masses sounded on these occasions. [less ▲]

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See detailSeventeen copies of the human 37 kDa laminin receptor precursor/p40 ribosome-associated protein gene are processed pseudogenes arisen from retropositional events
Jackers, Pascale ULg; Clausse, Nathalie; Fernandez, Maria-Teresa et al

in Biochimica et Biophysica Acta (1996), 1305(1-2), 98-104

A cDNA coding for a 37 kDa polypeptide has been identified in several species as both the potential precursor of the 67 kDa laminin receptor (37LRP) and a putative ribosome-associated protein (p40 ... [more ▼]

A cDNA coding for a 37 kDa polypeptide has been identified in several species as both the potential precursor of the 67 kDa laminin receptor (37LRP) and a putative ribosome-associated protein (p40). Interestingly, increased expression of this polypeptide (37LRP/p40) is consistently observed in invasive and metastatic cancer cells and is associated with poor prognosis. Southern-blot analysis of human genomic DNA predicted multiple copies of the 37LRP/p40 gene. In this study, we report that the number of copies of this sequence in the human genome is 26 +/- 2. We have sequenced and analyzed 19 genomic clones corresponding to the 37LRP/p40 gene and found that they were all processed pseudogenes. They all lack intronic sequences and show multiple genetic alterations leading in some cases to the appearance of stop codons. Moreover, they all bear characteristic features of retroposons as the presence of a poly(A)-tail at their 3' end and short direct repeated flanking DNA sequences. None of the pseudogenes analyzed present cis-elements in their 5' flanking region such as TATA or GC boxes. Our date reveal that over 50% of the 37LRP/p40 gene copies are pseudogenes most probably generated by retropositional events. The finding of multiple pseudogenes for the 37LRP/p40 suggests that the accumulation of several copies of this gene might have given a survival advantage to the cell in the course of evolution. [less ▲]

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See detailComet C/1996 B2 (Hyakutake)
Tichy, M.; Galad, A.; Pravda, A. et al

in Minor Planet Electronic Circulars (1996)

Available from the Minor Planet Center.

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See detailWR22: the most massive Wolf-Rayet star ever weighed.
Rauw, Grégor ULg; Vreux, Jean-Marie ULg; Gosset, Eric ULg et al

in Astronomy and Astrophysics (1996), 306

The results of an extensive spectroscopic campaign on the eclipsing binary WR22 are presented. A new radial velocity curve is deduced for the WN7 component, allowing us to improve the parameters of the ... [more ▼]

The results of an extensive spectroscopic campaign on the eclipsing binary WR22 are presented. A new radial velocity curve is deduced for the WN7 component, allowing us to improve the parameters of the orbit, formerly determined on the basis of photographic spectra. The high signal-to-noise ratio of our data also allows the detection of some weak absorption lines which, for the first time, can definitely be attributed to the companion. A study of their radial velocities gives a mass ratio of m_WR_/m_O_=2.78 leading to a minimum mass of 72M[SUB]sun[/SUB]_ for the WN7 star. The companion can be classified as a "late O" (O6.5-O8.5) star with a luminosity ratio of the system q=L_WR_^y^/L_O_^y^ at 5500A of about 8. The exceptionally high mass of the WN7 star and its high hydrogen mass-fraction suggest that WR22 is at the beginning of its Wolf-Rayet evolution. As a matter of fact, with such a high mass, WR22 most probably is still a hydrogen burning object. Therefore, the WN7 component is much closer to a main sequence O star with a "Wolf-Rayet clothing" than to the other members of the Wolf-Rayet family, which are rather highly evolved He-burning descendants of massive progenitors. [less ▲]

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See detailThe screening of species in a Darwinistic tree-like model of evolution
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physica D: Nonlinear Phenomena (1996), 90(3), 262-270

Numerical and theoretical investigations of a tree-like model of self-organized critical evolution are presented. The screening of species from the evolution process is numerically studied. Critical ... [more ▼]

Numerical and theoretical investigations of a tree-like model of self-organized critical evolution are presented. The screening of species from the evolution process is numerically studied. Critical exponents for (i) the avalanche distribution, (ii) the correlation function, (iii) the order parameter and (iv) the fraction of unscreened species are given. A mean-field approximation is developed. This theory is quite accurate for describing the critical state but is not able to describe the transient regimes, i.e. the self-organized slowing down of both order parameter and fraction of unscreened species towards the critical state. [less ▲]

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See detailExistence of a short period (3.5-4 hours) in the photometric variability of WR 66.
Rauw, Grégor ULg; Gosset, Eric ULg; Manfroid, Jean ULg et al

in Astronomy and Astrophysics (1996), 306

We report here on an independent detection of a short period (~4hours) in the photometric variations of WR66, thus confirming in broad terms the discovery by Antokhin et al.. In addition, we present the ... [more ▼]

We report here on an independent detection of a short period (~4hours) in the photometric variations of WR66, thus confirming in broad terms the discovery by Antokhin et al.. In addition, we present the first spectroscopic variability analysis for this star. A few peculiarities of the spectrum of WR66 are also discussed. Finally, we perform a brief examination of different possible origins of the phenomenon. [less ▲]

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See detailHybridization effects in U2T2X compounds: Magnetic structures of U2Rh2Sn and U2Ni2In
Nakotte, Heinz; Purwanto, A.; Robinson, R. A. et al

in Physical Review. B : Condensed Matter (1996), 53(6), 3263-3271

The tetragonal intermetallic compounds U2Ni2In and U2Rh2Sn have been studied by means of specific-heat, electrical-resistivity, and neutron-diffraction techniques. At low temperatures, both compounds ... [more ▼]

The tetragonal intermetallic compounds U2Ni2In and U2Rh2Sn have been studied by means of specific-heat, electrical-resistivity, and neutron-diffraction techniques. At low temperatures, both compounds order antiferromagnetically in a magnetic unit cell doubled along the c axis, and we find 5f moments of 0.60 and 0.38 Bohr magneton/U atom for U2Ni2In and U2Rh2Sn, respectively. For U2Ni2In, our refinement also indicates a possible Ni moment of 0.37 Bohr magneton perpendicular to the U moments. We discuss the development of the 5f moments together with findings on other isostructural U2T2X (T=transition metal, X=In, Sn) compounds, and confirm that the trends expected due to 5f-ligand hybridization also hold for this family of uranium compounds. Our analysis indicates different arrangements of the 5f moments in the two compounds (noncollinear arrangement within the basal plane for U2Ni2In and collinear arrangement along the c axis for U2Rh2Sn), although both compounds have nearest-neighbor U-U distances along the c axis. This would mean that the magnetocrystalline anisotropy in U2T2X compounds is not determined by nearest-neighbor U-U links alone [less ▲]

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See detailModel-Based Automatic Target Recognition (ATR) System for Forwardlooking Groundbased and Airborne Imaging Laser Radars (LADAR)
Verly, Jacques ULg; Delanoy, Richard L.

in Proceedings of the IEEE (1996), 84(2), 126-163

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See detailControl of the biodegradation rate of poly(DL-lactide) microparticles intended as chemoembolisation materials
Grandfils, Christian ULg; Flandroy, P.; Jérôme, Robert ULg

in Journal of Controlled Release (1996), 38(2-3), 109-122

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different ... [more ▼]

There is an interest in polylactide microspheres that biodegrade within a few days, particularly for chemoembolization applications. For this purpose, two poly(DL-lactide) samples of a very different molecular weight have been combined. The basic concept relies upon the capability of the high molecular weight component (Mn: 65 000) to provide the microspheres with a high mechanical strength, whereas the low molecular weight component (Mn: 3500) should decrease the particle lifetime dramatically. It has been shown that changing the weight ratio of these two components is an efficient way to control the kinetics of the in vitro degradation of poly(DL-lactide) microspheres on the expected time scale. The microspheres have been prepared by the oil-in-water emulsion/evaporation process, and their final polymer content has been compared to the initial composition of the oil phase. They have also been analyzed by differential scanning calorimetry to know whether the two polymers form a monophase blend or not. Kinetics of the in vitro biodegradation has been estimated from the decrease in molecular weight of the constitutive poly(DL-lactide)s, the time-dependency of the microsphere weight and the observation of changes in the morphology by scanning electron microscopy. Progress in the hydrolysis of the ester groups has also been reckoned from the increasing acidity of the incubation medium and associated with the polymer. [less ▲]

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See detailStaging of Non-Small-Cell Lung Cancer by Whole-Body Fluorine-18 Deoxyglucose Positron Emission Tomography
Bury, Thierry ULg; Dowlati, A.; Paulus, Patrick et al

in European Journal of Nuclear Medicine (1996), 23(2), 204-6

Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue ... [more ▼]

Positron emission tomography (PET) using fluorine-18 deoxyglucose (FDG), showing increased FDG uptake and retention in malignant cells, has been proven useful to differentiate malignant from benign tissue. We undertook a prospective study in 61 patients to compare the accuracy of whole-body FDG PET and conventional imaging (CI) methods for the staging of non-small-cell lung cancer (NSCLC). CI included chest and abdomen computed tomographic scanning and bone scintigraphy. When CI or PET study suggested metastatic disease, confirmation was obtained by biopsy or clinical or radiological follow-up. As compared to CI, PET correctly changed the N stage in 13 patients (21%) and the M stage in six patients (10%). There were three false-positive and no false-negative distant PET findings. Our preliminary results show that whole-body FDG PET can improve the diagnostic accuracy in the staging of NSCLC. [less ▲]

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See detailMédecins généralistes wallons. Quelles prescriptions aux personnes âgées de plus de 75 ans?
Franck, Jacques ULg; Ludovicy, R.; Taziaut, P. et al

in Revue Médicale de Liège (1996), 51(2), 163-74

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See detailMacromolecular engineering of polylactones and polylactides. 21. Controlled synthesis of low molecular weight polylactide macromonomers
Barakat, Ibrahim; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1996), 34(3), 497-502

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See detailHet meisje dat ik Ursula noem. Paul van Ostaijens 'Jong landschap' re-revisited
Spinoy, Erik ULg

in Kunst & Cultuur (1996), 29(2), 16-20

This is a rereading of a famous late poem by the Flemish expressionist Paul van Ostaijen.

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See detailAntibiothérapie topique et infections cutanées
Henry, Frédérique ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Revue Médicale de Liège (1996), 51(2), 160-162

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du ... [more ▼]

Les infections cutanées bactériennes, qui restent souvent limitées en extension, méritent un traitement local. Dans cette indication, l'antibiothérapie topique est toujours d'actualité. Le choix du médicament doit être guidé par son spectre d'activité. Les risques de développement d'une résistance bactérienne et d'une hypersensibilité allergique à l'antibiotique ou à sa base galénique doivent également être pris en considération. [less ▲]

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See detailGlucoindole Alkaloids from Stem Bark of Strychnos Mellodora
Tits, Monique ULg; Brandt, V.; Wauters, Jean-Noël ULg et al

in Planta Medica (1996), 62(1), 73-4

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical ... [more ▼]

Three glucoindole alkaloids, dolichantoside (1), strictosidine (2), and palicoside (3), have been identified in the stem bark of Strychnos mellodora (Loganiaceae), collected in Zimbabwe. The chiroptical (CD) data are compared. [less ▲]

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See detailIn Vitro and in Vivo Stimulation of the Murine Immune System by Agm-1470, a Potent Angiogenesis Inhibitor
Antoine, Nadine ULg; Daukandt, M.; Heinen, Ernst ULg et al

in American Journal of Pathology (1996), 148(2), 393-8

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that ... [more ▼]

AGM-1470, a potent angiogenesis inhibitor, is already engaged in phase I clinical trials because of its effectiveness to restrain tumor growth and its lack of major side effects. Recently, we showed that AGM-1470 stimulates in vitro human B lymphocyte proliferation through T lymphocytes. These data prompted us to explore the in vivo effects of AGM-1470 on the immune system in a mouse model. In this study, we showed that AGM-1470, in synergy with phytohemagglutinin, stimulates the proliferation of murine lymphocytes isolated from lymph nodes. This effect was similar to the one observed with human lymphocytes. When injected subcutaneously or intraperitoneally into mice at pharmacological doses, AGM-1470 induced a significant increase of axillary and mesenteric lymph nodes, respectively. Histological and morphological analyses showed that this phenomenon is mostly due to a hyperplasia of the germinal centers. On average, the area of the germinal center of lymph nodes from AGM-1470-treated mice were three times larger than in lymph nodes from control mice. Interestingly, no effect was observed when AGM-1470 was injected subcutaneously into T-deficient nude mice. Our data demonstrate that AGM-1470 stimulates B cell proliferation in vivo as suggested by the in vitro experiments. This effect should be taken into account in the follow-up of patients treated with this molecule and calls for additional studies to determine the biological consequences of such a stimulation on the host immune system. [less ▲]

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See detailContingency severity assessment for voltage security using non-parametric regression techniques
Wehenkel, Louis ULg

in IEEE Transactions on Power Systems (1996), 11(1), 101-111

This paper proposes a novel approach to power system voltage security assessment exploiting nonparametric regression techniques to extract simple, and at the same time reliable, models of the severity of ... [more ▼]

This paper proposes a novel approach to power system voltage security assessment exploiting nonparametric regression techniques to extract simple, and at the same time reliable, models of the severity of a contingency, defined as the difference between pre- and post-contingency load power margins. The regression techniques extract information from large sets of possible operating conditions of a power system screened offline via massive random sampling, whose voltage security with respect to contingencies is pre-analyzed using an efficient voltage stability simulation. In particular, regression trees are used to identify the most salient parameters of the pre-contingency topology and electrical state which influence the severity of a given contingency, and to provide a first guess transparent approximation of the contingency severity in terms of these latter parameters. Multilayer perceptrons are exploited to further refine this information. The approach is demonstrated on a realistic model of a large scale voltage stability limited power system, where it shows to provide valuable physical insight and reliable contingency evaluation. Various potential uses in power system planning and operation are discussed [less ▲]

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See detailPoetry as Enforcement: Conquering the Muse in Keats's 'Ode to Psyche'
Steyaert, Kris ULg

in Romanticism on the Net (RoN) (1996), 1(1),

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See detailReversal of Acute Renal Failure by Kidney Revascularisation
Van Damme, Hendrik ULg; Rorive, Georges ULg; Limet, Raymond ULg

in European Journal of Vascular and Endovascular Surgery (1996), 11(2), 134-9

OBJECTIVES: To assess whether acute renal failure, due to total or subtotal renal artery occlusion, can be reversed by kidney revascularisation. DESIGN: A retrospective review of surgery for kidney ... [more ▼]

OBJECTIVES: To assess whether acute renal failure, due to total or subtotal renal artery occlusion, can be reversed by kidney revascularisation. DESIGN: A retrospective review of surgery for kidney salvage in anuric patients at a University Hospital. METHODS: From 1983 to 1993, eight patients were operated on for occlusive renal artery disease as a cause of acute renal failure, requiring preoperative haemodialysis. On admission the mean serum creatinine was 40 mg/l (354 mumol/dl). The oligoanuria lasted from 12 h to 3 weeks. Renal length of 8 cm or more and visualisation of a patent distal renal artery branches on aortography were arguments that return of renal function could be expected after revascularisation of these non-functioning kidneys. RESULTS: Revascularisation restored immediate urine flow in six cases, with no further need for dialysis in four. Two patients remained oliguric despite successful reperfusion. One of them could be weaned from dialysis after 1 month. Two patients died postoperatively. Five of the eight patients left the hospital with restored renal function. CONCLUSIONS: Patients with acute renal function deterioration due to ischemia of a single or both kidneys can benefit from prompt revascularisation, with significant recovery of renal function in most of them. [less ▲]

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See detailKinking of the Internal Carotid Artery: Clinical Significance and Surgical Management
Van Damme, Hendrik ULg; Gillain, Daniel ULg; Desiron, Quentin ULg et al

in Acta Chirurgica Belgica (1996), 96(1), 15-22

The authors report on 62 surgical corrections for kinking of the internal carotid artery during a 13-year period (1980-1993). This represents 2.8% of all carotid operative procedures (n = 2188) in the ... [more ▼]

The authors report on 62 surgical corrections for kinking of the internal carotid artery during a 13-year period (1980-1993). This represents 2.8% of all carotid operative procedures (n = 2188) in the same period. It always concerned a significant (< 60 degrees) angulation of a redundant internal carotid artery, that in all but 3 cases was associated with atherosclerotic involvement of the carotid bifurcation. The indication to surgery included transient hemispheric or ocular ischaemia in 25.5% of cases, a regressive neurologic deficit in 8%, a minor stroke in 3%, a stroke in evolution in 11%, and non-lateralized cerebral ischaemia in 21%. In 19 patients (31%) it concerned an asymptomatic high degree stenosis. The surgical technique consisted in carotid transposition-reimplantation after eversion endarterectomy in 37 cases, in posterior transverse plication with patch angioplasty in 20 cases, and in segmental excision with venous interposition graft in 5 cases. There was one postoperative death. The morbidity include one ipsilateral non-fatal stroke and 3 transient ischaemic attacks. A complete long-term follow-up (mean duration 3.4 years) is available for 57 patients. The late incidence of stroke is 1.5% per year. The 5-year survival attains 67%. These long-term results are comparable to the outcome of standard endarterectomy in the same institution. The authors discuss the indication, techniques, and outcome of surgical correction of kinked internal carotid artery. They recommend a shortening procedure, often associated with endarterectomy for severely kinked vessels (angulation 60 degrees or less), symptomatic or not. [less ▲]

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See detailBlood Mononuclear Cells Mobilization and Cytokines Secretion During Prolonged Exercises
Bury, Thierry ULg; Louis, Renaud ULg; Radermecker, Maurice ULg et al

in International Journal of Sports Medicine (1996), 17(2), 156-60

This study was designed to compare the effects of three prolonged exercises varying in their intensity and duration, on blood mononuclear cell mobilization and cytokine secretion (IL1(1)-IL(2)). Seven ... [more ▼]

This study was designed to compare the effects of three prolonged exercises varying in their intensity and duration, on blood mononuclear cell mobilization and cytokine secretion (IL1(1)-IL(2)). Seven healthy subjects underwent three effort trials (45 % VO(2)max during 4 h - 60% VO(2)max during 3 h - 75 % VO(2)max during 2 h) at one-month intervals. Blood samples were drawn before, different times during exercise and also after exercise. Prolonged exercises induced a transient increase in blood mononuclear cells which occurred across all intensity levels. We also observed a significant increase in plasma IL(1) level during exercise which correlates with the exercise intensity. The mean IL(1) level increased up to 2.5 times after the three proposed exercises (p <0.05). Plasma IL(2) level decreased at the end of prolonged exercises irrespective of the exercise intensity. No correlation was observed between blood mononuclear count and cytokine determination. Our data suggest that blood mononuclear cells mobilization is associated but not correlated with alterations of cytokine levels. [less ▲]

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See detailCriticality of trapping in a dynamic epidemic model
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal of Physics : A Mathematical & General (1996), 29(2), 309-316

We study a simple model mimicking the two-dimensional growth of a solid interface B through a liquid L in presence of particles A which are pushed by the advancing front. The model considers a short-range ... [more ▼]

We study a simple model mimicking the two-dimensional growth of a solid interface B through a liquid L in presence of particles A which are pushed by the advancing front. The model considers a short-range repulsive interaction between the particles and the advancing front (the so-called Uhlmann, Chalmers and Jackson mechanism). As particles are pushed by the advancing front, this leads to the formation of aggregates which are hindrances to the growth and which can be trapped leading to the formation of internal patterns. A transition between indefinitely growing clusters and frozen ones takes place for a critical particle fraction x(c) = 0.560 +/- 0.005 which is larger than the critical fraction of the corresponding epidemic model with static particles. At that critical threshold x, both percolating clusters and internal patterns are numerically found to be fractal with the same dimension D-f = 1.87 +/- 0.03 close to the classical percolation exponent 91/48. The correlation length exponent v is found to be v = 1.34 +/- 0.08 close to the classical percolation exponent 4/3. The criticality of the internal patterns is unexpected. [less ▲]

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See detailHigh Level of Mt-Mmp Expression Is Associated with Invasiveness of Cervical Cancer Cells
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1996), 65(2), 209-13

MMP-2 (gelatinase A) has been associated with the invasive potential of many cancer cells both in vitro and in vivo. It is now becoming clear that the activation of this enzyme might be a key step in ... [more ▼]

MMP-2 (gelatinase A) has been associated with the invasive potential of many cancer cells both in vitro and in vivo. It is now becoming clear that the activation of this enzyme might be a key step in tumor invasion. This activation process has been shown to be a membrane-associated pathway inducible by various agents such as collagen type I, concanavalin A or TGF-beta, but its physiological regulation is still largely unresolved. MT-MMP was recently discovered and described as a potential gelatinase-A activator. In the present study, we investigated the expression of MT-MMP (membrane-type metalloproteinase) in cervical cancer cells both in vitro and in vivo. Comparing several in vitro-transformed cervical cell lines, previously shown to display different invasive potentials, our results showed that the ability of cells to overexpress MT-MMP mRNA following ConA induction correlated with their ability to activate gelatinase A and with a highly invasive behavior. Moreover, using immunohistochemistry and in situ hybridization, we found a higher level of MT-MMP expression in invasive cervical carcinoma and lymph node metastases compared to its expression in non-invasive CIN III lesions. Our in vivo observations also clearly demonstrated a cooperation between stromal and tumor cells for the production of MT-MMP. Taken together, our results clearly correlated high level MT-MMP expression with invasiveness, and thus suggested that MT-MMP might play a crucial role in cervical tumor invasion. [less ▲]

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See detailThe enigmatic flarings of HR2517.
Sterken, C.; Manfroid, Jean ULg

in Astronomy and Astrophysics (1996), 305

We report the discovery of strong flaring of the B3 II-III star HR2517. The evidence is based on Stroemgren differential uvby photometry spanning more than a decade. We discuss the behaviour of HR2517 in ... [more ▼]

We report the discovery of strong flaring of the B3 II-III star HR2517. The evidence is based on Stroemgren differential uvby photometry spanning more than a decade. We discuss the behaviour of HR2517 in terms of two models, viz. a rooted bright spot suddenly appearing and developing with modulation in photospheric temperature producing periodic light and profile variations as the star rotates, or that HR2517 is a Be star in an eccentric (P~33-34d) high-mass X-ray binary (HMXB) with neutron star companion--one of the brightest such systems known. [less ▲]

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See detailEmpirical study of departures from the excitation equilibrium of FeI in metal-poor stars.
Magain, Pierre ULg; Zhao, G.

in Astronomy and Astrophysics (1996), 305

A detailed analysis of neutral iron lines in a sample of 13 metal-poor dwarfs and subgiants is carried out on the basis of high resolution spectra obtained with the ESO Coude Echelle Spectrometer. The ... [more ▼]

A detailed analysis of neutral iron lines in a sample of 13 metal-poor dwarfs and subgiants is carried out on the basis of high resolution spectra obtained with the ESO Coude Echelle Spectrometer. The deduced iron abundance is found to depend on the excitation potential of the line used, higher excitation lines generally indicating higher abundances. This could be caused by departures from the local thermodynamic equilibrium (LTE) or by temperature inhomogeneities in the stellar atmospheres. The dependency of this effect on the stellar atmospheric parameters is investigated. From the comparison of iron lines with lines of other elements, it is concluded that the low excitation FeI lines are much more affected than the high excitation lines. The consequences of these effects for the classical abundance analyses are examined. It is found that they may explain, at least in part, some previously reported discrepancies between the results of different authors. [less ▲]

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See detailLes anesthésiques
Larbuisson, Robert ULg; Lamy, Maurice ULg

in Revue Médicale de Liège (1996), 51(1), 129-32

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See detailEffects of Testosterone and Its Metabolites on Aromatase-Immunoreactive Cells in the Quail Brain: Relationship with the Activation of Male Reproductive Behavior
Balthazart, Jacques ULg; Foidart, Agnès ULg; Absil, Philippe ULg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 185-200

The enzyme aromatase converts testosterone (T) into 17 beta-estradiol and plays a pivotal role in the control of reproduction. In particular, the aromatase activity (AA) located in the preoptic area (POA ... [more ▼]

The enzyme aromatase converts testosterone (T) into 17 beta-estradiol and plays a pivotal role in the control of reproduction. In particular, the aromatase activity (AA) located in the preoptic area (POA) of male Japanese quail is a limiting step in the activation by T of copulatory behavior. Aromatase-immunoreactive (ARO-ir) cells of the POA are specifically localized within the cytoarchitectonic boundaries of the medial preoptic nucleus(POM), a sexually dimorphic and steroid-sensitive structure that is a necessary and sufficient site of steroid action in the activation of behavior. Stereotaxic implantation of aromatase inhibitors in but not around the POM strongly decreases the behavioral effects of a systemic treatment with T of castrated males. AA is decreased by castration and increased by aromatizable androgens and by estrogens. These changes have been independently documented at three levels of analysis: the enzymatic activity measured by radioenzymatic assays in vitro, the enzyme concentration evaluated semi-quantitatively by immunocytochemistry and the concentration of its messenger RNA quantified by reverse transcription-polymerase chain reaction (RT-PCR). These studies demonstrate that T acting mostly through its estrogenic metabolites regulates brain aromatase by acting essentially at the transcriptional level. Estrogens produced by central aromatization of T therefore have two independent roles: they activate male copulatory behavior and they regulate the synthesis of aromatase. Double label immunocytochemical studies demonstrate that estrogen receptors(ER) are found in all brain areas containing ARO-ir cells but the extent to which these markers are colocalized varies from one brain region to the other. More than 70% of ARO-ir cells contain detectable ER in the tuberal hypothalamus but less than 20% of the cells display this colocalization in the POA. This absence of ER in ARO-ir cells is also observed in the POA of the rat brain. This suggests that locally formed estrogens cannot control the behavior and the aromatase synthesis in an autocrine fashion in the cells where they were formed. Multi-neuronal networks need therefore to be considered. The behavioral activation could result from the action of estrogens in ER-positive cells located in the vicinity of the ARO-ir cells where they were produced (paracrine action). Alternatively, actions that do not involve the nuclear ER could be important. Immunocytochemical studies at the electron microscope level and biochemical assays of AA in purified synaptosomes indicate the presence of aromatase in presynaptic boutons. Estrogens formed at this level could directly affect the pre-and post-synaptic membrane or could directly modulate neurotransmission namely through their metabolization into catecholestrogens (CE) which are known to be powerful inhibitors of the catechol- omicron - methyl transferase (COMT). The inhibition of COMT should increase the catecholaminergic transmission. It is significant to note, in this respect, that high levels of 2-hydroxylase activity, the enzyme that catalyzes the transformation of estrogens in CE, are found in all brain areas that contain aromatase. On the other hand, the synthesis of aromatase should also be controlled by estrogens in an indirect, transynaptic manner very reminiscent of the way in which steroids indirectly control the production of LHRH. Fibers that are immunoreactive for tyrosine hydroxylase (synthesis of dopamine), dopamine beta-hydroxylase (synthesis of norepinephrine) or vasotocine have been identified in the close vicinity of ARO-ir cells in the POM and retrograde tracing has identified the origin of the dopaminergic and noradrenergic innervation of these areas. A few preliminary physiological experiments suggest that these catecholaminergic inputs regulate AA and presumably synthesis. [less ▲]

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See detailLes bisphosphonates
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1996), 51(1), 120-2

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See detailLa calcitonine
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1996), 51(1), 116-9

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See detailLes facteurs de croissance hematopoiétiques
Fillet, Georges ULg

in Revue Médicale de Liège (1996), 51(1), 102-6

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See detailJ03.13 A and B: a new multiply imaged QSO candidate.
Claeskens, Jean-François ULg; Surdej, Jean ULg; Remy, M.

in Astronomy and Astrophysics (1996), 305

Careful analysis of direct R CCD frames obtained for selected Highly Luminous Quasars in March 1993 with the MPI/ESO 2.2m telescope has revealed that the quasar J03.13 consists of at least two point-like ... [more ▼]

Careful analysis of direct R CCD frames obtained for selected Highly Luminous Quasars in March 1993 with the MPI/ESO 2.2m telescope has revealed that the quasar J03.13 consists of at least two point-like components, constituting therefore a new gravitational lens candidate. Follow-up direct imagery of this interesting object with the New Technology Telescope (NTT) + SUSI in February 1994, using the Bessel B, R and Gunn-i filters, tends to confirm the gravitational lens hypothesis. The mean angular separation and magnitude difference between the A & B images are found to be 0.84"+/-0.03" and 2.1+/-0.1mag, respectively. A spatially unresolved, medium resolution spectrum of J03.13, obtained with the NTT + EMMI in February 1994, shows that the QSO has a redshift z=2.55, with Lyalpha and CIV absorptions at z=2.34 and MgII, MgI and FeII absorptions at z=1.085. The latter absorptions might be associated with a sigma=206km/s lens galaxy. B, R and Gunn-i photometric observations of J03.13 during 1994 and 1995 do not show evidence for flux variations exceeding 0.03mag. HST direct imagery with WFPC2 and FOS spectroscopy of J03.13 A & B are planned during cycle 5. [less ▲]

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See detailLes fluoroquinolones
Damas, Pierre ULg

in Revue Médicale de Liège (1996), 51(1), 50-52

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See detailLes anti-inflammatoires non stéroïdiens
Malaise, Michel ULg

in Revue Médicale de Liège (1996), 51(1), 123-125

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See detailHistoire et perspective du traitement par diurétiques
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1996), 51(1), 30-34

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces ... [more ▼]

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces dernières années, suite au développement de nouvelles options thérapeutiques, les diurétiques ont été décriés en raison de quelques effets secondaires. Cette classe thérapeutique reste cependant un pilier solide et incontournable dans les états de rétention hydrosodée comme par exemple la décompensation cardiaque ou dans l'hypertension artérielle du sujet âgé. Quoi qu'il en soit, le développement de nouveaux diurétiques vit au ralenti en raison de l'acceptation relativement faible de nouvelles molécules, commercialisées pourtant à très faible dose, c'est-à-dire sans action principale sur la volémie. Les modulateurs du transport d'ions, dérivés des structures moléculaires non diurétiques parmi les familles de diurétiques ouvrent cependant des voies intéressantes dans le traitement de maladies diverses. [less ▲]

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See detailTrophoblast-specific processing and phosphorylaton of pregnancy-associated glycoprotein-1 in day 15 to 25 sheep placenta
Xie, S.; Nagel, R. J.; Green, J. et al

in Biology of Reproduction (1996), 54(1), 122-129

Bovine and ovine pregnancy-associated glycoproteins-1 (PAG-1) are products of binucleate trophoblast cells and belong to the aspartic proteinase gene family. Estimates of their relative molecular masses ... [more ▼]

Bovine and ovine pregnancy-associated glycoproteins-1 (PAG-1) are products of binucleate trophoblast cells and belong to the aspartic proteinase gene family. Estimates of their relative molecular masses have varied considerably, from 47 to 90 kDa, even though the mature polypeptide has been inferred to be no more than 330 amino acids in length and that the glycosylated recombinant form synthesized in Chinese hamster ovary (CHO) or COS-1 cells had an apparent mass of 46 kDa. To establish the relationships among the various molecular forms, metabolic labeling, immunoprecipitation, and electrophoretic analysis were used to follow the biosynthesis of ovine PAG-1 (ovPAG-1) in placental explants. In time-course studies, ovPAG-1 could first be detected within 10 min as a 70-kDa form within the tissue. With time, forms of intermediate (53-61 kDa) and low (47 kDa) molecular mass began to accumulate. The latter predominated in medium after 6 h labeling. Pulse chase studies established that the 70-kDa forms were the precursors of the smaller species. Inhibition of glycosylation with tunicamycin or treatment with N-glycosidase F confirmed that ovPAG-1 contained N-linked oligosaccharide chains, but that this carbohydrate accounted for only a relatively small fraction (8-10 kDa) of the apparent mass. Consecutive treatment with neuraminidase and O-glycanase also reduced the apparent molecular mass of the precursor by approximately 11 kDa. OvPAG-1 incorporated 32P from [32P]orthophosphate into phosphoserine and phosphothreonine, but there was no incorporation of 35S from [35S]sulfate. The basis of the differences in molecular mass between the precursor and the final products remains to be elucidated, but the differences seem likely to be due to some unusual form of posttranslational modification introduced in the binucleate cell. The results of the study appear to explain the disparate size values that have been reported for these placenta-derived proteins. [less ▲]

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See detailVariability in Estimation of Coronary Dimensions from 6f and 8f Catheters
Legrand, Victor ULg; Raskinet, B.; Martinez, Christophe ULg et al

in Catheterization and Cardiovascular Diagnosis (1996), 37(1), 39-4546

To investigate the suitability of diagnostic 6F catheters for coronary angiographic measures in the clinical setting, we determined the relative accuracy and reproducibility of the measures obtained with ... [more ▼]

To investigate the suitability of diagnostic 6F catheters for coronary angiographic measures in the clinical setting, we determined the relative accuracy and reproducibility of the measures obtained with these catheters as scaling devices in 59 stenoses. Comparison was made with duplicate injections, obtained before angioplasty, using an 8F guiding catheter as scaling device. Intra- and interobserver variability was evaluated in 15 stenoses. The coefficient of variation averaged 18.3% for the minimal lumen diameter, 10.4% for the percent stenosis, and only 7.4% for the reference diameter. Reproducibility of angiographic measures done with the 6F catheter was similar to that obtained with the 8F catheter, although accuracy was lower with the 6F for the measurement of reference diameter. Thus, quantitative coronary angiography (QCA) measures derived from routine diagnostic angiograms may be suitable for determination of reference diameter, allowing enough precision for determination of the size of a coronary device for intervention, but these measures may lack accuracy for precise determination of minimum diameter and percent stenosis, making their use questionable in studies looking at individual changes in coronary stenosis dimensions. [less ▲]

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See detailMaurice Streel, an annotated list of his publications.
Steemans, Philippe ULg; Loboziak, S

in Annales de la Société Géologique de Belgique (1996), 117

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See detailDecrease in systemic tolerance to fed ovalbumin in indomethacin-treated mice.
Louis, Edouard ULg; Franchimont, D.; Deprez, Manuel ULg et al

in International Archives of Allergy & Immunology (1996), 109(1), 21-6

The oral administration of non-steroidal anti-inflammatory drugs (NSAID) to animals induces a quick increase in intestinal permeability and secondary inflammatory lesions of the intestine. The mechanisms ... [more ▼]

The oral administration of non-steroidal anti-inflammatory drugs (NSAID) to animals induces a quick increase in intestinal permeability and secondary inflammatory lesions of the intestine. The mechanisms leading to the inflammatory lesions are hypothetical. The increased intestinal permeability could allow a greater mucosal and systemic penetration of fed antigens and bacterial products leading to an abnormal mucosal and systemic immune and inflammatory response toward these materials. We examined the effect of oral dosing with indomethacin on ovalbumin serum levels and the systemic immune response to ovalbumin in mice fed with ovalbumin. The ovalbumin serum level was higher in indomethacin-treated mice and the increase was proportional to the dose of indomethacin. It was associated with epithelial and subepithelial lesions. Moreover, the systemic humoral and, to a lesser extent, the cellular tolerance were partially abrogated in the treated mice. These findings suggest that the oral administration of indomethacin in mice induces an increased passage of fed antigen through the intestinal epithelium associated with a decrease in systemic tolerance to this antigen. The reason for this decrease remains unclear. Besides a disequilibrium between systemic and mucosal immune responses, a loss of integrity of the intestinal epithelial cells and a direct immunomodulating effect of indomethacin may also be involved. This decrease in systemic tolerance to luminal antigen could be involved in the development of NSAID enteropathy. [less ▲]

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See detailInsulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells
l'Allemand, D.; Penhoat, A.; LEBRETHON, Marie-Christine ULg et al

in The Journal of clinical endocrinology and metabolism (1996), 81(11), 3892-7

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation ... [more ▼]

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation. In the present study, we examined the long term effects of IGF-I and -II on human adult adrenal fasciculata-reticularis cells cultured in a chemically defined medium and compared them to the effects of insulin, human GH, and ACTH. Treatment for 3 days with IGF-I or -II at nanomolar concentrations or with insulin at micromolar concentrations slightly increased the production of androstenedione, cortisol, and dehydroepiandrosterone about 1.5-fold over that by control cells. Moreover, the acute steroidogenic response to ACTH of cells pretreated with IGF-I, IGF-II, or insulin was 3- to 6-fold higher than that of control cells. For each hormone, these effects of IGF-I and -II were dose dependent between 0.1-26 nmol/L (1-200 ng/mL). The secretion of androstenedione was more potently stimulated than that of dehydroepiandrosterone and cortisol, and this effect was more clearly yielded by pretreatment with IGF-II than with IGF-I or insulin. Human GH had no effect on these cells. In cells treated with IGF-I or -II, the messenger ribonucleic acid (mRNA) levels of cytochrome P450 17 alpha-hydroxylase and of 3 beta-hydroxysteroid dehydrogenase were increased, and the abundance of ACTH receptor mRNA was also slightly enhanced, but the mRNA of cytochrome P450 cholesterol side-chain cleavage enzyme was unchanged. In conclusion, IGFs enhance the steroidogenesis and ACTH responsiveness of human adrenocortical cells in culture. We speculate, that by this mechanism, IGFs may contribute to clinical states with hyperandrogenemia. [less ▲]

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See detailDescription des plantules de quatre Caesalpiniacées africaines
Léonard, J.; Doucet, Jean-Louis ULg

in Bulletin du Jardin Botanique National de Belgique = Bulletin van de Nationale Plantentuin van België (1996), 66

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See detailA computer controlled PIGE setup for the analysis of thin samples
Strivay, David ULg; Garnir, Henri-Pierre ULg; Weber, Georges

in Nuclear Instruments & Methods in Physics Research Section B (1996), 113(1-4), 407-410

A computer controlled PIGE setup has been improved by adding a beam energy disperser which whips out most of the structure of the proton excitation functions and allows better analysis of thin samples.

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See detailL'échec, un problème de culture pédagogique
Crahay, Marcel ULg

in Journal of Education (1996), Octobre

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See detailHydrology and fluvial dynamics, in Geography Research in Belgium, Comité National de Géographie, DENIS J. (Ed.)
Petit, François ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1996)

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See detailInfluence of Van Hove singularity on the electronic specific heat of high-Tc superconductors
Dorbolo, Stéphane ULg; Houssa, Michel; Ausloos, Marcel ULg

in Physica C: Superconductivity (1996)

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See detailTo be or not to be at home ? A neuropsychologica approach to delusion for place
Sellal, F.; Fontaine, S. F.; Van der Linden, Martial ULg et al

in Journal of Clinical & Experimental Neuropsychology (1996), 18

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See detailBibliographie de Jean Haust
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1996), 23-24

Bibliographie de Jean Haust et index raisonné de l'ensemble de l'oeuvre.

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See detailTables quinquennales
Lecocq, Pascale ULg

in Actualités du droit (1996)

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See detailThe relation of ventilatory failure to pulmonary, respiratory muscle and central nervous system disturbances in calves with an experimentally produced pneumonia
Desmecht, Daniel ULg; Linden, Annick ULg; Lekeux, Pierre ULg

in Journal of Comparative Pathology (1996), 115(3), 203-219

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a ... [more ▼]

To explore the pathophysiology of respiratory failure in an experimental pneumonia, a Pasteurella haemolytica broth culture was injected intratracheally into 12 calves, which were then studied over a period of 10 h. Measurements were made of inspired minute ventilation VE), ventilatory pattern [inspiratory time (TI), expiratory time (TE), respiratory rate (RR) and tidal volume (VT)], transdiaphragmatic pressure (Pdi), occlusion pressure at the airway opening 100 milliseconds after onset of inspiration (Pawo100ms), arterial blood gas tensions and pH and recorded diaphragmatic electromyogram (EMGdi) and rectal temperature (Tr). On and after the third hour after inoculation, the animals varied in respect of clinical signs, Tr, RR, VE, Pawo100ms/EMGdi, and arterial gases and pH. In benign cases, diminished alertness, laboured respiration and fall of arterial oxygen pressure (PaO2) worsened up to 7 h after inoculation, but then progressively improved, VE being maintained at approximately 150% baseline throughout the study (10 h). Neither arterial carbon dioxide pressure (PaCO2) nor pH was altered. Moderate cases resembled benign cases in respect of laboured respiration, VE, PaO2 and PaCO2; however, pH was at first maintained at preinoculation levels, but declined thereafter. In severe cases, the animals were drowsy between hours 3 and 7, and became comatose between hours 8 and 10; in contrast to both benign and moderate cases: (1) RR was reduced by hour 5, (2) there was no trend towards recovery of PaO2 and pH, (3) VE, Pdi, Pawo100ms and Pawo100ms/EMGdi were severely decreased, and (4) PaCO2 increased. These results suggest that pneumonia does not alter ventilatory neuromuscular pump function in calves, unless concomitant cardiovascular collapse occurs. It is not clear whether fatal ventilatory failure is caused mainly by deterioration in ventilatory muscle fibre processes or structures, altered central nervous system adjustment of ventilatory timing, or cardiovascular dysfunction. However, inspiratory pressures fall when excitation to the diaphragm is still growing, which suggests peripheral respiratory muscle fatigue. [less ▲]

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See detailLa place actuelle de l'immunoanalyse en Toxicologie Clinique
Charlier, Corinne ULg; Plomteux, Guy ULg

in Immuno-Analyse & Biologie Spécialisée [=IBS] (1996), 11

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See detailThe Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment: Deployment on the ATLAS Space Shuttle missions
Gunson, Michael R.; Abbas, M. M.; Abrams, M. C. et al

in Geophysical Research Letters (1996), 23(17), 2333-2336

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events ... [more ▼]

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events provided measurements of more than 30 atmospheric trace gases at latitudes 3-49 degrees N and 65-72 degrees S, including observations both inside and outside the Antarctic polar vortex. The instrument configuration, data retrieval methodology, and mission background are described to place in context analyses of ATMOS data presented in this issue. [less ▲]

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See detailCritical Evaluation of the DNA-methyl Green Assay: Application to Some Indole Alkaloids
Bonjean, K.; De Pauw-Gillet, Marie-Claire ULg; Bassleer, R. et al

in Phytotherapy Research (1996), 10

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt ... [more ▼]

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt, mitomycin C, emetine or colchicine). This test showed some promise as a screening technique for substances that intercalate partly or totally into the DNA helix but it is not suitable for substances that bind covalently to DNA. An application of this test to a number of indole alkaloids was also performed. Cryptolepine, serpentine, alstonine and matadine induced a reduction of the colour of the solution, so indicating an interaction with DNA. [less ▲]

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See detailConditional heteroskedasticity adjusted market model and an event study
Corhay, Albert ULg; Tourani-Rad, Alireza

in Quarterly Review of Economics and Finance (1996), 36(4), 529-538

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See detailThe Use Of N-15-Labeled Dietary Proteins For Determining True Ileal Amino Acid Digestibilities Is Limited By Their Rapid Recycling In The Endogenous Secretions Of Pigs
Leterme, Pascal; Thewis, André ULg; Francois, Etienne et al

in Journal of Nutrition (1996), 126(9), 2188-2198

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary ... [more ▼]

We assessed the use of 15N-labeled dietary proteins as a possible tool for the determination of the true ileal amino acid (AA) digestibility in pigs. The first experiment was designed to study the dietary N excretion pattern at the ileum subsequent to the ingestion of a single 15N-labeled meal. In a second experiment, we compared ileal endogenous AA outputs and true AA digestibility estimates obtained in pigs ingesting 15N-labeled dietary proteins in a single meal vs. intravenous infusion of 15N-leucine for 10 d during the ingestion of a pea-based diet and a protein-free starch diet. The proportion of endogenous N found in the ¡leal digesta differed when the label was delivered orally (50%) vs. intravenously (72%) and changed with time. As a consequence, the true ileal AA digestibilities measured with labeled diets were lower. A third experiment demonstrated that this was due to the rapid recycling of labeled dietary N in endogenous moieties, because 15N was found in blood within 10 min of consuming the labeled meal, within 50 min of consumption in pancreatic enzymes, 90 min in bile and 4 h in ¡leal mucins. We conclude that the use of 15N-labeled meals for determination of true ¡leal AA digestibilities is limited by the fast recycling of dietary N in endogenous secretions following a single 15N-labeled meal. The accuracy of results will depend on meaningful estimates of AA flow during a limited period and accurate estimates of 15N in AA. [less ▲]

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See detailLe cas clinique du mois : syndrome de Moskowitz chez un patient traité par ticlopidine
FRANCHIMONT, D; Freres, Pierre ULg; LEBRUN, F et al

in Revue Médicale de Liège (1996), 51(3), 214-216

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See detailSuppression of Voluntary Temporalis Muscle Activity by Peripheral Limb Stimulations in Healthy Volunteers, Migraineurs and Tension-Type Headache Sufferes
Wang, W.; Schoenen, Jean ULg

in Functional Neurology (1996), 11(6, Nov-Dec), 307-15

We studied the inhibition of voluntary temporalis muscle activity after stimulations of extracephalic cutaneous or mixed nerves in 23 healthy volunteers, 29 patients suffering from migraine without aura ... [more ▼]

We studied the inhibition of voluntary temporalis muscle activity after stimulations of extracephalic cutaneous or mixed nerves in 23 healthy volunteers, 29 patients suffering from migraine without aura, 24 from episodic and 42 from chronic tension-type headache. Two successive EMG suppressions were induced bilaterally after stimulating at 40 mA the index finger or the median nerve, but not after stimulations of the sural or peroneal nerves. They differed from those obtained after labial commissure stimulation at 20 mA, i.e. the classic temporalis silent periods ES1 and ES2. Overall prevalence of index- (3%) and median nerve-induced (16%) early suppression was much lower than that of labial-induced ES1 (100%); prevalence of index-induced late suppression (index-"ES2") was 62% and that of median-"ES2" 48%, compared with 97% for labial-ES2. Latency and duration of index-/median-"ES2" were not significantly different between groups. Index-"ES2" occurred significantly more often in migraineurs (83%) than in controls (48%) suggesting that the spino-bulbar pathways involved in index-/median-"ES2" are hyperexcitable in migraine. [less ▲]

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See detailLes infections utérines dans l’espèce bovine: 1. Aspects étiologiques et épidémiologiques
Hanzen, Christian ULg; Houtain, J. Y.; Laurent, Y.

in Point Vétérinaire (1996), 28(numéro spécial), 1013-1017

Assessing the frequency of metritis shows the animal uterine health as well as the herd . The practitioner prefers to use vaginal examination. The great diversity and variation postpartum in germs ... [more ▼]

Assessing the frequency of metritis shows the animal uterine health as well as the herd . The practitioner prefers to use vaginal examination. The great diversity and variation postpartum in germs responsible for uterine diseases make it difficult to interpret bacteriology. Uterine diseases are all the more frequent as the interval between calving and clinical examination is shorter, therefore the practitioner screening needs to be done as soon as possible. This recommendation is valid for the primiparous dairy cow as well as the suckler cow [less ▲]

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See detailInteraction Of The Macrolide Azithromycin With Phospholipids .2. Biophysical And Computer-Aided Conformational Studies
Montenez, Jp.; Vanbambeke, F.; Piret, J. et al

in European Journal of Pharmacology (1996), 314(1-2), 215-27

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits ... [more ▼]

In a comparison paper, we show the azithromycin causes a lysosomal phospholipidosis in cultured cells, binds in vitro to negatively charged bilayers without causing aggregation or fusion, and inhibits lysosomal phospholipase A1. In this paper, we show that azithromycin decreases the mobility of the phospholipids in negatively charged liposomes (using 31P nuclear magnetic resonance) and that it increases the fluidity of the acyl chains close to the hydrophilic/hydrophobic interface, but not deeper into the hydrophobic domain (assessed by measuring the fluorescence polarization of trimethylammonium-diphenylhexatriene and diphenyhexatriene, respectively). Computer-aided conformational analysis of mixed monolayers of azithromycin and phosphatidylinositol shows that the drug can be positioned largely in the hydrophobic domain, but close to the interface, with the macrocycle facing the C1 of the fatty acids (allowing the N9a endocyclic tertiary amine to interact with the phospho-groups), the cladinose located on the hydrophobic side of the lipid/water interface and the desosamine projected into the hydrophobic domain. This position is consistent with the experimental data. Analysis of virtual molecules shows that this unanticipated behavior to the shielding of the ionizable N3' amino-group in the desosamine by methyl-groups, and to the wide dispersion of hydrophobic domains all over the molecule. The interaction of azithromycin with phospholipids may account for some of its unusual pharmacokinetic properties and for its potential to cause lysosomal phospholipidosis. [less ▲]

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See detailPollution des sols : interventions et responsabilités des pouvoirs publics
Delnoy, Michel ULg

in Sols contaminés, sols à décontaminer (1996)

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See detailA novel three-enzyme reaction cycle for the synthesis of N-acetyllactosamine with in situ regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose
Zervosen, Astrid ULg; Elling, Lothar

in Journal of the American Chemical Society (1996), 118(8), 1836-1840

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in ... [more ▼]

A new three-enzyme reaction cycle consisting of sucrose synthase, UDP glucose 4‘-epimerase, and human β-1,4-galactosyltransferase was established for the synthesis of N-acetyllactosamine (LacNAc) with in situ regeneration of UDP galactose. We found that UDP glucose 4‘-epimerase is reductively inactivated in the presence of UMP and acceptor substrates of β-1,4-galactosyltransferase. Reactivation of UDP glucose 4‘-epimerase by the transition state analogues dUDP or dTDP 6-deoxy-d-xylo-4-hexulose in combination with the repetitive batch technique enabled us to use the native enzymes for 11 days in this cycle. With 10 U of sucrose synthase, 5 U of UDP glucose 4‘-epimerase, and 1.25 U of β-1,4-galactosyltransferase, 594 mg of LacNAc could be synthesized. N-Acetyllactosamine was also subsequently converted to Neu5Acα2,6Galβl,4GlcNAc with α-2,6-sialyltransferase and CMP-Neu5Ac. [less ▲]

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See detailFusogenic Properties Of The C-Terminal Domain Of The Alzheimer Beta-Amyloid Peptide
Pillot, T.; Goethals, M.; Vanloo, B. et al

in Journal of Biological Chemistry (1996), 271(46), 28757-65

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was ... [more ▼]

A series of natural peptides and mutants, derived from the Alzheimer beta-amyloid peptide, was synthesized, and the potential of these peptides to induce fusion of unilamellar lipid vesicles was investigated. These peptide domains were identified by computer modeling and correspond to respectively the C-terminal (e.g. residues 29-40 and 29-42) and a central domain (13-28) of the beta-amyloid peptide. The C-terminal peptides are predicted to insert in an oblique way into a lipid membrane through their N-terminal end, while the mutants are either parallel or perpendicular to the lipid bilayer. Peptide-induced vesicle fusion was demonstrated by several techniques, including lipid-mixing and core-mixing assays using pyrene-labeled vesicles. The effect of peptide elongation toward the N-terminal end of the entire beta-amyloid peptide was also investigated. Peptides corresponding to residues 22-42 and 12-42 were tested using the same techniques. Both the 29-40 and 29-42 beta-amyloid peptides were able to induce fusion of unilamellar lipid vesicles and calcein leakage, and the amyloid 29-42 peptide was the most potent fusogenic peptide. Neither the two mutants or the 13-28 beta-amyloid peptide had any fusogenic activity. Circular dichroism measurements showed an increase of the alpha-helical content of the two C-terminal peptides at increasing concentrations of trifluoroethanol, which was accompanied by an increase of the fusogenic potential of the peptides. Our data suggest that the alpha-helical content and the angle of insertion of the peptide into a lipid bilayer are critical for the fusogenic activity of the C-terminal domain of the amyloid peptide. The differences observed between the fusogenic capacity of the amyloid 29-40 and 29-42 peptides might result from differences in the degree of penetration of the peptides into the membrane and the resulting membrane destabilization. The longer peptides, residues 22-42 and 12-42, had decreased, but significant, fusogenic properties associated with perturbation of the membrane permeability. These data suggest that the fusogenic properties of the C-terminal domain of the beta-amyloid peptide might contribute to the cytotoxicity of the peptide by destabilizing the cell membrane. [less ▲]

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See detailGastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease.
Dowlati, A; Bury, Thierry ULg; CORHAY, Jean-Louis ULg et al

in Thorax (1996), 51(12), 1270-2

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and ... [more ▼]

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and serum of patients with lung cancer. Based on these preliminary data a study was conducted to evaluate the usefulness of gastrin measurements in the diagnosis and staging of lung cancer. METHODS: Thirty-five patients with lung cancer (26 non-small cell (NSCLC) and nine small cell (SCLC)) and 25 patients with chronic obstructive pulmonary disease underwent fibreoptic bronchoscopy and BAL. Gastrin levels were determined in both BAL fluid and the serum and compared with each other and with staging. RESULTS: No difference was found between the gastrin levels in the BAL fluid or serum of the study groups. There was no correlation with the stage in NSCLC and no correlation was found between the gastrin levels in the serum and the BAL fluid. A significant difference was seen in gastrin levels in BAL fluid between extensive and limited SCLC (p < 0.05). CONCLUSION: There is no evidence of clinical usefulness for gastrin measurements in lung cancer. [less ▲]

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See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

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See detailA propos de la genèse des orthostates néo-assyriens
Tunca, Önhan ULg

in Tablettes et images aux pays de Sumer et d'Akkad. Mélanges offerts à Monsieur H. Limet (A.P.H.A.O. Mémoires n° 1) (1996)

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See detailSanglante campagne en Tchétchénie
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailLocalization of nucleic acids in hepatocyte nucleoli of rats upon D-galactosamine-induced block of transcription.
Mikhaylova, V. T.; Thiry, Marc ULg; Stephanova, E. et al

in Experimental Cell Research (1996), 225(2), 389-98

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection ... [more ▼]

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection: osmium-ammine staining and terminal deoxynucleotidyl transferase reaction for DNA, and immunoelectron microscopy with anti-RNA antibodies, RNase-gold, and autoradiography with tritiated orotic acid for RNA. The blocking of transcription was followed by the disappearance of intranucleolar condensed chromatin. Agglomerates of thin extended DNA filaments were found to change their location to the nucleolar periphery and to coalesce with each other. At the last stage of nucleolar segregation they were concentrated at the pole of the nucleolar fibrillar remnant while the rest of the nucleolus did not contain any DNA. No DNA was found in the dense fibrillar component of both intact and treated hepatocyte nucleoli. During the process of nucleolar segregation the bulk of the nucleolar RNA was found within the so-called spherical bodies. This RNA appeared to be synthesized shortly before or even after drug administration. The results obtained are in agreement with the hypothesis that the fibrillar centers are the site of nucleolar transcription. They also show that uncompleted molecules of pre-rRNA whose synthesis has been blocked are segregated from the rest of nucleolar RNA species into the spherical bodies. [less ▲]

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See detailRheumatic and musculoskeletal diseases and impaired quality of life. A challenge for rheumatologists
Morales-Torres, J; Reginster, Jean-Yves ULg; Hochberg, MC

in Journal of Rheumatology (1996), 23

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See detailImportance Of The Hydrophobic Energy: Structural Determination Of A Hypoglycemic Drug Of The Meglitinide Family By Nuclear Magnetic Resonance And Molecular Modeling
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj. et al

in Biochemical Pharmacology (1996), 52(8), 1155-68

The molecular structure of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionic acid (KAD-1229), a hypoglycemic drug of the meglitinide family, was studied by nuclear magnetic resonance (NMR ... [more ▼]

The molecular structure of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionic acid (KAD-1229), a hypoglycemic drug of the meglitinide family, was studied by nuclear magnetic resonance (NMR) and molecular modeling. The results of the NMR experiments indicated that KAD-1229 existed in solution in the form of two stable conformers of equal population, called KADI and KADII in this paper. Three different molecular modelings were then applied: the classical molecular dynamics using the commercial Biosym and Hyperchem softwares and the Prot+ program, which is not based on a dynamical study but on a systematic conformational analysis of the molecule, which includes a term that allows the estimation of the hydrophobic interaction. The modeling results showed the following points. First, in contrast with classical molecular dynamics, which uses restraints from two-dimensional nuclear Overhauser effect (NOE) data, the Prot+ KAD structure provides conformations that support experimental NMR data without any external intervention. In the structures in agreement with NMR data, an important hydrophobic interaction between the phenyl cycle and the perhydroisoindole ring of KAD is observed. This interaction, which seems to play a role in the biological activity of the drug, is lost when no restraints are considered in classical molecular dynamics. Second, the difference between KADI and KADII arises mainly from slight distance geometric differences at the level of the perhydroisoindole and the phenyl rings. [less ▲]

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See detailA study of general practitioners' prescribing behaviour to the elderly in Wallonia, Belgium
Taziaux, P.; Franck, J.; Ludovicy, R. et al

in European Journal of Public Health (1996), 6(1)

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See detailThe attenuated V60 strain of channel catfish virus possesses a deletion in ORF50 coding for a potentially secreted glycoprotein
Vanderheijden, NATHALIE; Alard, PHILIPPE; Lecomte, CORINE et al

in Virology (1996), 218(2), 422-6

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion ... [more ▼]

A wild-type strain of channel catfish virus was compared at the genomic level with the attenuated strain V60. In addition to several minor differences, restriction mapping revealed one major deletion (approximately 1200 bp) in ORF50 of the V60 strain. Cloning and sequencing of part of this ORF confirmed the presence of a 1164-bp deletion. It should result in a protein of 282 amino acids instead of 670. The predicted truncated protein lacks most of a threonine-rich, highly repetitive region in its central part. Since the protein encoded by ORF50 possesses a hydrophobic N-terminal leader sequence and no membrane anchor sequence, we suggest that it could be a secreted glycoprotein. This protein might be N-glycosylated (35 potential sites) and, given the repetitive arrangement of its residues (mainly threonines), also heavily O-glycosylated like the mucin-type glycoproteins. The deletion observed in ORF50 of the V60 strain implies the loss of 24 potential N-glycosylation sites and should considerably reduce the extent of O-glycosylation. [less ▲]

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See detailQuel encadrement pour quelle qualité de l'enseignement?
Lafontaine, Dominique ULg

in Pilotinfo (1996), (13), 1-8

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See detailDeposition in the Distal Parts of the Bovine Respiratory Tract: Assessment of Equipment Suitable for Drug Inhalation
Genicot, Bruno; Votion, Dominique ULg; Munsters, K. et al

in Veterinary Record : Journal of the British Veterinary Association (1996), 138(13), 302-304

The efficiency of equipment suitable for the inhalation of drugs by calves was assessed in six animals which inhaled radioisotopically labelled particles while suffering from reversible diffuse ... [more ▼]

The efficiency of equipment suitable for the inhalation of drugs by calves was assessed in six animals which inhaled radioisotopically labelled particles while suffering from reversible diffuse bronchoconstriction induced experimentally with 5-hydroxytryptamine and while they were breathing normally. Respiratory rates and data from pulmonary function tests and scintiscans were recorded during both investigations. After the first investigation, a mean (se) wash-out period of 9.8 (3.2) days was allowed. Under diffuse bronchoconstriction, the respiratory rate, the oscillatory resistance and the compliance of the respiratory system reached 282.1 (22.0), 161.1 (10.8) and 68.8 (2.7) per cent of their respective baseline values. When the calves were breathing normally these parameters did not change over time. The ratios (Cp/Ct) of the counts of gamma-disintegrations in the peripheral part (Cp) of the lungs and in the total lung area (Ct) were not significantly different when comparing the results from the two investigations. The ratios of Cp/Ct in the left lungs did not differ significantly from those in the right lungs. [less ▲]

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See detailLe cas clinique du mois. Hemochromatose genetique
Collignon, Nathalie ULg; Delwaide, Jean ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1996), 51(2), 150-153

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See detailSeasonal temperature and salinity fields in the Mediterranean Sea: Climatological analyses of a historical data set
Brasseur, P.; Beckers, Jean-Marie ULg; Brankart, J. M. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (1996), 43(2), 159-192

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly ... [more ▼]

Climatological analyses of a historical data base have been carried out with the aim of reconstructing the three-dimensional temperature and salinity fields in the Mediterranean Sea. Seasonal and monthly distributions of hydrographic properties have been computed by a variational inverse method as an alternate to the standard Gandin (1969; Objective analysis of meterological fields, Israeli Program for Scientific Translation, Jerusalem) procedure. The spline solutions of the minimization problem are demonstrated to be numerically and theoretically equivalent to field estimates obtained by conventional objective analysis. The application of a finite-element technique allows analysis to be performed in the model space rather than in the observational space, which substantially improves the numerical efficiency of the procedure. The parameters of the scheme are adjusted according to the statistics of the climatological data. The results,realized as gridded data sets (horizontal resolution of 0.25 degrees), show some trends in seasonal variability affecting the properties of water masses. As expected, the upper layer is subject to a well-defined seasonal signal affecting both the temperature and salinity fields. Error maps, reflecting the degree of uncertainty in the analyses, have been systematically produced. The present work is conceived as a basic support to more advanced studies such as diagnostic calculations, initialization of dynamical models, assimilation of hydrological data into primitive equation models, or planning of experimental surveys. New versions of the climatological fields will be released as data are added to the historical data base. Copyright (C) 1996 Elsevier Science Ltd. [less ▲]

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See detailCombined enzymatic synthesis of nucleotide (deoxy) sugars from sucrose and nucleoside monophosphates
Zervosen, Astrid ULg; Stein, Andreas; Adrian, Holger et al

in Tetrahedron (1996), 52(7), 2395-2404

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside ... [more ▼]

Abstract: The synthesis of NDP-glucose 3a-d (N= A, C, U, dU) with sucrose synthase B was combined with the enzymatic synthesis of nucleoside diphosphates 2a-d from their corresponding nucleoside monophosphates la-d by different kinases A. Further combination with recombinant dTDP-glucose 4,6-dehydratase D enabled us to synthesize dUDP-6-deoxy-alpha-D-xylo-4-hexulose 5 from ld on a preparative scale. By using the repetitive batch technique the enzymatic syntheses of nucleotide (deoxy) sugars 3a-d, 5 could be realized on a 0.1 - 0.5 g scale. [less ▲]

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See detailImproved RAPD amplification of recalcitrant plant DNA by the use of activated charcoal during DNA extraction.
Vroh Bi, I.; Harvengt, L.; Chandelier, A. et al

in Plant Breeding (1996), 115(3),

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See detailRevascularisation rénale pour sauvetage ou préservation néphronique
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Gillain et al

in Revue Médicale de Liège (1996), 51(2), 175-86

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse ... [more ▼]

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse rénale (sténoses serrées concernant les deux reins ou un rein unique) compromet la filtration glomérulaire et constitue une des rares formes d'insuffisance rénale chronique réversible. Actuellement, 30 à 50% des patients sélectionnés pour une revascularisation rénale ont une fonction rénale altérée. L'histoire naturelle des sténoses rénales (surtout les lésions athéroscléreuses) montre une évolutivité vers l'obstruction progressive avec perte de parenchyme fonctionnel. Une revascularisation rénale envisage soit la protection du capital néphronique (intervention prophylactique), soit un sauvetage néphronique (restauration ou stabilisation d'une fonction rénale déjà altérée). Les critères prédictifs de bénéfice à long terme sont analysés. Les rôles respectifs de l'angioplastie transluminale percutanée et de la chirurgie sont discutés. L'intérêt de la revascularisation rénale sur la fonction rénale a été apprécié chez 23 malades réno-vasculaires et azotémiques (créatinine > 20 mg/l) ainsi que chez 8 patients en oligoanurie d'origine ischémique. [less ▲]

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See detailImages liées à la pathologie traumatique du système nerveux central
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Acta Paediatrica Belgica (1996), 28(3), 216

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See detailInfections oculaires traumatiques et iatrogènes: prélèvements et rôle du laboratoire
Melin, Pierrette ULg

in Bulletin de la Société Belge d'Ophtalmologie (1996), 260

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological ... [more ▼]

Ocular inflammations may be due to a variety of diseases, and microorganisms play a major role in both acute and chronic eye diseases. Treatment of serious infections needs a good microbiological diagnostic. The indications and techniques for investigations are determined by the site of infection, severity of the process, and knowledge of the likely responsible organisms. Immediate inoculation of specimens on culture media in the examining room is often recommended. This article describes organisms associated with ocular infections, and is designed to assists ophthalmologists in the collection, processing and transport of specimens. [less ▲]

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See detailPaget’s disease of bone : diagnosis and management
Hosking, D; Meunier, PJ; Ringe, JD et al

in British Medical Journal (1996), 312

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See detailHigh rotational excitation of NO infrared thermospheric airglow: A signature of superthermal nitrogen atoms?
Hubert, Benoît ULg; Gérard, Jean-Claude ULg; Shematovich, Valeri I et al

in Geophysical Research Letters (1996), 23

The reaction between superthermal N([SUP]4[/SUP]S) atoms produced by exothermic processes and O[SUB]2[/SUB] has been proposed to explain observations of highly rotationally excited nitric oxide in the ... [more ▼]

The reaction between superthermal N([SUP]4[/SUP]S) atoms produced by exothermic processes and O[SUB]2[/SUB] has been proposed to explain observations of highly rotationally excited nitric oxide in the sunlit thermosphere. We examine the importance of this mechanism using a detailed calculation of the fast N([SUP]4[/SUP]S) atoms energy distribution. It is shown that the hot thermal N atoms are able to produce rotationally excited NO in the upper thermosphere through the reaction of O[SUB]2[/SUB] with N([SUP]4[/SUP]S). By contrast, near the NO peak at 110 km, the Maxwellian nitrogen atoms produce substantially less rovibrationally excited NO than the superthermal component. Consequently, the non Maxwellian N([SUP]4[/SUP]S) atoms show a clear spectral signature in the (1-0) and (2-1) bandheads at this altitude. The calculated rovibrationally excited NO concentration at 140 km is shown to be consistent with the value derived from the analysis of infrared airglow spectra. [less ▲]

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See detail"Vielen Dank und auf Wiedersehen" : Mitteilungen an das Publikum in den Kinoprogrammen der Frühzeit
Belloi, Livio ULg

in KINtop : Jahrbuch zur Erforschung des frühen Films (1996), 5

Etude des vues d'annonce au public telles que la firme Lumière en a très tôt l'intuition, mais qui se développent surtout à partir de 1906, en conjonction avec l'émergence progressive des salles fixes et ... [more ▼]

Etude des vues d'annonce au public telles que la firme Lumière en a très tôt l'intuition, mais qui se développent surtout à partir de 1906, en conjonction avec l'émergence progressive des salles fixes et spécialisées, c'est-à-dire en même temps que l'apparition de cette instance historiquement constituée qu'est le spectateur de cinéma. [less ▲]

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See detailFactors influencing the behavior of steel columns exposed to fire
Talamona, Didier; Kruppa, Joël; Franssen, Jean-Marc ULg et al

in Journal of Fire Protection Engineering (1996), 8(1), 31-43

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See detailClimatology
Erpicum, Michel ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1996), 64 (2)

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See detailDeficient Habituation of Evoked Cortical Potentials in Migraine: A Link between Brain Biology, Behavior and Trigeminovascular Activation?
Schoenen, Jean ULg

in Biomedicine & Pharmacotherapy (1996), 50(2), 71-8

According to recent evoked potential studies, a fundamental, probably protective, feature of cortical information processing, ie, response habituation during stimulus repetition, is abnormal in migraine ... [more ▼]

According to recent evoked potential studies, a fundamental, probably protective, feature of cortical information processing, ie, response habituation during stimulus repetition, is abnormal in migraine between attacks. The deficient habituation is found for different sensory modalities and experimental paradigms: pattern-reversal visual evoked potentials (same stimulus at a constant intensity), cortical auditory evoked potentials (same stimulus at increasing intensities) and auditory event-related potentials obtained in a passive "oddball" paradigm (novel stimulus). The abnormal information processing is an interictal cortical dysfunction most likely due to inadequate control by the so-called "state-setting, chemically-addressed pathways" originating in the brain stem, in particular by the serotonergic pathway, leading to a low preactivation level of sensory cortices. We suggest that it may play a pivotal role in migraine pathogenesis in conjunction with the reported decrease of brain mitochondrial energy reserve, by favouring a rupture of metabolic homeostasis and biochemical shifts capable of activating the trigeminovascular system and thus capable of producing a migraine attack. We postulate that both the deficient habituation in information processing and the deranged oxygen metabolism may have behavioral correlates. Which of these abnormalities are inherited, acquired or both remains to be determined. [less ▲]

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See detailAbsolute configuration of (R)-1-phenylethyl ammonium (S)-2-(6-methoxy-2-naphthyl)-propionate
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

in Acta Crystallographica (1996), C52

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See detailAlteration of the endocrinological status of growing calves by a glucocorticoids treatment
Massart, Serge; Bertozzi, Carlo; Prandi, Alberto et al

in Journal of Animal Science (1996), 74(suppl 1), 230

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See detailHypertension and left ventricular hypertrophy
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg; Van Cauwenberge, Henry

in Acta Cardiologica (1996), 51(2), 143-154

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age ... [more ▼]

In response to high blood pressure, left ventricular hypertrophy develops. But in hypertension, the myocardial hypertrophied structure is abnormal. The prevalence of this hypertrophy is influenced by age, gender, weight, race, genetics and the severity of high blood pressure. By echocardiography, it has been possible to detect non invasively and more precisely this hypertrophy and its anatomical pattern which is not uniform. This cardiac response is influenced by hemodynamic but also by non hemodynamic factors, but the exact mechanisms are not yet well understood. The humoral and tropic factors particularly affect the cardiac remodeling. Left ventricular hypertrophy has been noted by itself to be an independent risk factor for sudden death, ventricular arrhythmias, myocardial ischemia, and heart failure. Very early hypertension, diastolic dysfunction is noted. The progression to systolic failure in moderate hypertension usually occurs over several decades. According to the worse prognosis of left ventricular hypertrophy, it has been suggested that the reversibility of this anatomical modification by antihypertensive treatment is beneficial. Preliminary data support this idea. [less ▲]

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See detailFirst synthesis of 4-substituted benzenesulfonylcyanoguanidines
Masereel, B.; Lebrun, P.; Dogne, J.-M. et al

in Tetrahedron Letters (1996), 37

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See detailQuantitative measurement of metal ions concentration of proteins separated by electrophoresis
Weber, Georges ULg; Strivay, David ULg; Menendez, M. et al

in International Journal of PIXE (1996), 1-2

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the ... [more ▼]

This communication is devoted to nature determination and quantification by PIXE of metals contained in proteins after their separation by PolyAcrylamide Gel Electrophoresis (PAGE). After the electrophoresis, the gel is dried and each track is scanned with a 2.5 MeV proton beam which triggers metal X-ray fluorescence and then, allows to determine the type of metals contained in an electrophoretic band. For quantitative determination of the amount of the metal contained inside the band, the characteristic X-ray peak area is compared with those obtained with polyacrylamide gels doped with the same metal. The normalization has been achieved by using RBS measurements on the gel itself. The procedure presented seems to be a very useful multielementary method for the metal content analysis and for the determination of the metal amounts inside proteins after their separation by electrophoresis. Furthermore it allows to check if metals remain bound to proteins. [less ▲]

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See detailEvaluation of the cranial rectus abdominus muscle pedicle flap as a blood supply for the caudal superficial epigastric skin flaps in dogs.
Degner, Daniel; Walshaw, Richard; Arnoczky, Steven et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1996), 25

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See detailCarotid Surgery in Octogenarians: Is It Worthwhile?
VAN DAMME, Hendrik ULg; Lacroix; Desiron, Quentin ULg et al

in Acta Chirurgica Belgica (1996), 96(2), 71-7

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in ... [more ▼]

Controversy surrounds the role of carotid endarterectomy in octogenarians. Although the prognosis of severe degree carotid stenosis is more ominous in the elderly, operative risk seems more important in the aged. To evaluate the presumed detrimental effect of advanced age on the mortality-morbidity of carotid endarterectomy, the authors reviewed their common experience with carotid surgery in patients aged 80 years or more. From 1980 to 1994, 129 octogenarians were operated on for occlusive carotid artery disease in two university hospitals. The data for these patients, 80 years of age and older (group 1) are compared to these for a large middle age group (less than 80 years) (group 2) operated by the same surgeons during that period. The baseline characteristics of both groups were similar, except for smoking, diabetes and previous myocardial revascularization, more prevalent in the younger age group. In the elderly group prophylactic surgery for asymptomatic stenosis was done in 36%, versus 40% of the middle aged patients, and for stroke in evolution in 8% versus 4% (p < 0.05). The perioperative stroke rate was 0.8% in the group older than 80 years, compared to 1.2% for non octogenarians (NS). The operative mortality was similar for both age groups (2.3 and 1.5 respectively). The long-term results gave a similar outlook for both age groups. The 5-year stroke-free rate reached 89% for group 1 versus 91% for group 2. The 5-year survival rate, however, was less for the elderly patients (47% versus 77%, mean follow-up periods of 30 and 49 months). These results suggest that carotid endarterectomy can be safely done in elderly patients, with a similar risk/benefit ratio as for the younger patients. Advanced age, by itself, is not to be considered as contraindication to carotid surgery. [less ▲]

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See detailActivation of ATP-dependant K+ channels and inhibition of insulin release: effect of BPDZ 62
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Journal of Pharmacology and Experimental Therapeutics (The) (1996), 277

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See detailcompte rendu de : T. Göransson, Albinus, Alcinous. Arius Didymus
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in Byzantion : Revue Internationale des Etudes Byzantines (1996)

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