References of "Scientific journals"
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See detailLes modes de transmission du virus de l'hépatite C
Delwaide, Jean ULg; Gerard, Christiane ULg; Sondag, Danièle ULg et al

in Médecine & Chirurgie Digestives (1997), 26

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See detailUsing the Global Positioning System to monitor active faults in “stable continental Europe”
Warnant, René ULg

in Aardkundige Mededelingen (1997), 8

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See detailComment je traite les hypertensions réfractaires
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1997), 52(1), 2-6

L'hypertension artérielle réfractaire représente 10% des hypertensions artérielles traitées. La définition, arbitraire, consiste en la persistance de valeurs de pression artérielle au-delà de 140/90 mmHg ... [more ▼]

L'hypertension artérielle réfractaire représente 10% des hypertensions artérielles traitées. La définition, arbitraire, consiste en la persistance de valeurs de pression artérielle au-delà de 140/90 mmHg malgré une trithérapie antihypertensive dont un diurétique. Ce traitement a été administré à dose optimale pendant une durée suffisante. La reconnaissance des vraies hypertensions réfractaires est la première démarche diagnostique (bonne mesure de la pression artérielle et authenticité de l'augmentation de pression). Ensuite il convient de rechercher une non-observance, une forme secondaire d'hypertension artérielle ou encore une résistance thérapeutique liée à un excès de poids et à un hyperinsulinisme. Cette démarche permettra de proposer un schéma thérapeutique approprié visant à normaliser la pression artérielle, gage d'un risque cardio-vasculaire atténué. Une prise en charge globale des facteurs de risque cardio-vasculaire trouve ici une pleine implication. [less ▲]

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See detailEffects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies.
Mouithys-Mickalad, Ange ULg; Deby, Ginette ULg; Hoebeke, Maryse ULg et al

in Mediators of Inflammation (1997), 6(5-6), 327-33

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of ... [more ▼]

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of sphingosine (SPN) and ceramide analogues on phorbol 12-myristate 13-acetate (PMA, 5 x 10(-7)M) stimulated PMN (6 x 10(6) cells). By ESR with spin trapping (100 mM DMPO: 5,5-dimethyl-1-pyrroline-Noxide), we showed that SPN (5 to 8 x 10(-6)M), C(2)-ceramide (N-acetyl SPN) and C(6)-ceramide (N-hexanoyl SPN) at the final concentration of 2 x 10(-5) and 2 x 10(-4)M inhibit the production of free radicals by stimulated PMN. The ESR spectrum of stimulated PMN was that of DMPO-superoxide anion spin adduct. Inhibition by 5 x 10(-6)M SPN was equivalent to that of 30 U/ml SOD. SPN (5 to 8 x 10(-6)M) has no effect on in vitro systems generating superoxide anion (xanthine 50 mM/xanthine oxidase 110 mU/ml) or hydroxyl radical (Fenton reaction: 88 mM H(2)O(2), 0.01 mM Fe(2+) and 0.01 mM EDTA). SPN and N-acetyl SPN also inhibited the CL of PMA stimulated PMN in a dose dependent manner (from 2 x 10(-6) to 10(-5)M), but N-hexanoyl SPN was less active (from 2 x 10(-5) to 2 x 10(-4)M). These effects were compared with those of known PMN inhibitors, superoxide dismutase, catalase and azide. SPN was a better inhibitor compared with these agents. The complete inhibition by SPN of ESR signal and CL of stimulated PMN confirms that this compound or one of its metabolites act at the level of NADPH-oxidase, the key enzyme responsible for production of oxygen-derived free radicals. [less ▲]

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See detailL’arsénopyrite du Massif de Stavelot, Belgique
Hatert, Frédéric ULg

in Bulletin de la Société Royale des Sciences de Liège (1997), 66

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See detailThe He(I), Threshold photoelectron and Constant Ion State spectroscopy of Vinylchloride (C2H3Cl).
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been ... [more ▼]

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been measured and reexamined. The threshold photoelectron spectrum has been measured between 9.0 and 25.0 eV and the photon energy range of 9.9-12.0 eV has been investigated in detail. Many features have been identified and tentatively assigned with the help of the photoabsorption spectroscopic results. These data were compared with the well-resolved He(I) photoelectron spectrum. The fine structure observed in the two first ionic states is assigned to progressions belonging partially to previously unobserved vibration normal modes. State-selected CIS spectra have been recorded for the first vibronic states between 10.0 and 11.67 eV. They exhibit fine structure assigned to autoionization of Rydberg states. [less ▲]

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See detailCaractéristiques microbiologiques et organoleptiques du nététu du commerce.
N'dir, B.; Gningue, B. D.; Keita, N. G. et al

in Cahiers Agricultures (1997), 6

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See detailMolecular cloning and chromosomal mapping of olfactory receptor genes expressed in the male germ line: evidence for their wide distribution in the human genome
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Biochemical and Biophysical Research Communications (1997), 237

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding ... [more ▼]

Olfactory receptor genes constitute the largest family of G protein-coupled receptors. We have previously shown that members of this family are expressed during spermatogenesis, and that the corresponding proteins are displayed on mature sperm cells. In each mammalian species, a restricted subset of olfactory receptors is expressed in male germ cells and displays a pattern of expression suggestive of their potential implication in the control of sperm physiology. In addition to the cDNA fragments available previously, we now report the molecular cloning of two olfactory receptor cDNAs from a human testis library. Five olfactory receptor genes expressed in germ cells were localized in the human genome by radiation hybrid mapping. Three of the genes map to the short arm of chromosome 19 (19p13.1-19p31.3), one to chromosome 11 (11q22.1-22.3), and one to chromosome 17 (17q21-22). The former two localizations fall within clusters previously identified for members of the putative olfactory receptor gene family expressed in olfactory mucosa. Similarly, sequence analysis has revealed that these testicular genes share no distinctive structural features from the other, non-testicular, members of the family. The expression of a subset of olfactory receptor genes in the male germ line is therefore not correlated to their belonging to a specific structural subgroup, or to a specific gene cluster or chromosomal segment [less ▲]

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See detailIndependent prognostic value of the 67-kd laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Menard, Sylvie et al

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

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See detailF. Furet : Le communisme. L'histoire d'une illusion
Melard, François ULg

in Recherches sociologiques (1997), 2

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See detailOnset Time of Neuromuscular Block and Intubating Conditions: Influence of Different Stimulation Patterns
Hans, Pol ULg; Dewé, Walthère ULg; Albert, Adelin ULg

in Acta Anaesthesiologica Belgica (1997), 48(1), 15-21

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See detailProtéinas placentárias em mamíferos
Melo de Sousa, Noelita; de Figueiredo, José Ricardo; Gonçalves, Paulo Bayard Dias et al

in Ciência Animal (1997), 7(1), 43-55

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins ... [more ▼]

During the past twenty years, several new placental proteins have been isolated and characterized in woman and several animal species. Among these proteins, it can be mentioned chorionic gonadotrophins, placental lactogens, interferon tau, pregnancy specific and pregnancy-associated glycoproteins. In spite of the importance of these studies, there are few papers that describe fundamental aspects of these placental proteins such as physical-chemical pregnancy diagnosis methods. Thus, the aim of this report is to present an overview on the major aspects of placental proteins studied up to now, as well as to consider perspectives for their applications in the future in veterinary practice. [less ▲]

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See detailComparison of radiography , magnetic resonance imaging and surgical findings in dogs with elbow dysplasia
Snaps, Frédéric ULg; Balligand, Marc ULg; Saunders, J. et al

in American Journal of Veterinary Research (1997), 58(12), 1367-1370

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for ... [more ▼]

Objective-To describe the magnetic resonance imaging (MRI) appearance of medial coronoid process and humeral condyle lesions in dysplastic cubital joints and to compare survey radiography and MRI for evaluation of fragmented medial coronoid process (FMCP) and lesions of the medial aspect of the humeral condyle (MAHC). Animals-18 dogs with elbow dysplasia. Procedure-Radiography of 22 cubital joints was performed. The 22 joints then underwent MRI. The scans were evaluated with regard to the shape and signal of the coronoid process; articular cartilage change, subchondral bone disruption of the MAHC. Surgical findings were used as the standard to calculate accuracy, sensitivity, specificity, and positive-and negative-predictive values for specific diagnosis of FMCP (free fragment) and lesions of the MAHC. Results-At surgery, 31.8% of the joints had FMCP (free), 36.4% had nondisplaced unmineralized coronoid process, and 27.2% had nondisplaced mineralized coronoid process, Eleven joints had lesions of the MAHC, and wear lesions were observed in 41% of the joints. On radiography, FMCP (free) was visualized in 9% of the joints and lesions of the MAHC were observed in 23%. MRI had the highest accuracy (95.5%), sensitivity (100%), and negative-predictive value (100%) for detection of FMCP (free), and had accuracy (91%), sensitivity (87.5%), specificity (92.5%), and positive (87.5%)- and negative (92.5%)- predictive values for detection of nondisplaced unmineralized coronoid process. Conclusions and Clinical relevance-Compared with radiography, MRI was useful for detection of nondisplaced unmineralized coronoid process; images consistently correlated with surgical findings. The technique is accurate and especially useful when radiographic findings are inconclusive. [less ▲]

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See detailPeroxidase isoenzymes in normal and habituated calli of sugar beet during transfer from light to darkness
Bernal, M. A.; Bisbis, B.; Pedreño, M. A. et al

in Biologia Plantarum (1997), 39(2), 161-168

Habituated sugar beet calli have been characterized as having a deficiency in some tetrapyrrole containing compounds. However, peroxidases might be dissociated from the other tetrapyrrole containing ... [more ▼]

Habituated sugar beet calli have been characterized as having a deficiency in some tetrapyrrole containing compounds. However, peroxidases might be dissociated from the other tetrapyrrole containing compounds. When light-cultured normal and habituated calli were transferred to darkness their peroxidase activity reduced and increased, respectively, indicating that habituation could not strictly be characterized by a deficiency in peroxidase content but rather by a different regulation of its activity. This regulation could be mediated through soluble effectors which act as potential peroxidase inhibitors and/or by a differential expression of the peroxidase isoenzyme patterns which were present in these tissues in both light and darkness. The different peroxidase activity and the nature of acidic and basic isoenzymes in normal and habituated tissues could explain the different features of both types of cultures. [less ▲]

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See detailSédimentologie des Formations de Marteau, du Bois d'Ausse et de la partie inférieure de la Formation d'Acoz (Dévonien inférieur) dans l'Est de la Belgique, au bord nord de Massif de Stavelot
Goemara, E.; Catot, E.; Dejonghe, L. et al

in Memoirs of the Geological Survey of Belgium (1997), 42

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailA Deletion in the Bovine Myostatin Gene Causes the Double-Muscled Phenotype in Cattle
Grobet, L.; Martin, L. J.; Poncelet, D. et al

in Nature Genetics (1997), 17(1), 71-74

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled ... [more ▼]

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia-that is, an increase in the number of muscle fibers rather than in their individual diameter. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (domainant and recessive), oligogenic and polygenic models have been proposed. In the Belgian Blue cattle breed (BBCB), segregation analysis performed both in experimental crosses and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGF beta superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle. [less ▲]

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See detailA propos de quelques utilisations non conventionnelles de la metformine
SCHEEN, André ULg; PAQUOT, Nicolas ULg; LETIEXHE, Michel ULg et al

in Médecine et Hygiène (1997), 55

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See detailDynamique de défense du nid chez Symphodus ocellatus (Forsskål, 1775), poisson labridé méditerranéen. I. Comportements agonistiques entre le mâle territorial nidificateur et cinq autres espèces de labridés
Ylieff, Marc ULg; Michel, Christian ULg; Voss, Jacques

in Cahiers d'Ethologie (1997), 17(1), 49-74

This research in the field consists of a study of interspecific agonistic behaviour of territorial male in Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions ... [more ▼]

This research in the field consists of a study of interspecific agonistic behaviour of territorial male in Symphodus ocellatus. This behaviour is useful for brood and nest defense. Four questions involving Symphodus ocellatus towards S. tinca, S. mediterraneus, S. roissali, Thalassoma pavo et Coris julis were investigated. The questions of interest were: (1) aggressors or intruders motivations (predation of the brood (a) and/or territorial conflicts (b)), (2) the recognition of this or that species (recognition studied with selective attacks by territorial male), (3) the organ(s) of perception used for this recognition and (4) the importance of territorial male investment in nest defense; this role could ensure a successful reproduction of the species. Our observations and experimentations (tested labrid fishes presented to T. males) allow us to affirm that in S. ocellatus, nesting territorial males recognize the various tested labrid fishes; that the organ of perception used for social recognition is the visual channel; that spawn protection insured by territorial male, a task guided by his visual system, is necessary towards menace of his congeners, but also the other fishes living in his habitat. Nevertheless, if it’s becoming clear that the Mediterranean labrid fishes have the ability to recognize and preferentially interact with particular individuals, the answer of the question 1, concerning aggressors motivations, is not yet clearly known. [less ▲]

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See detailClostridium spiroforme toxin genes are related to C. perfringens iota toxin genes but have a different genomic localization.
Gilbert, M.; Perelle, S.; Daube, Georges ULg et al

in Systematic & Applied Microbiology (1997), 20

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See detailEpilepsies rebelles de l'enfant: définition et modalités de prise en charge hospitalière
Leroy, Patricia; Dubru, Jean-Marie ULg; Misson, Jean-Paul ULg

in Neurone (1997), 2(8), 285-288

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See detailThe Cloning And Sequencing Of An Ovine C-Myc Cdna
Kiermer, V.; Dequiedt, Franck ULg; Masengo, R. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1997), 7(3-4),

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See detailMoufang affine buildings have Moufang spherical buildings at infinity
Van Maldeghem, H.; Van Steen, Kristel ULg

in Glasgow Mathematical Journal (1997), 39(Part 3), 237-241

We show in a direct and elementary way that the spherical building at infinity of every rank 3 affine building which satisfies Tits' Moufang condition, is itself a Moufang building. This result is also ... [more ▼]

We show in a direct and elementary way that the spherical building at infinity of every rank 3 affine building which satisfies Tits' Moufang condition, is itself a Moufang building. This result is also true for higher rank affine buildings by Tits' classification [4]. [less ▲]

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See detailMechanisms of Hand Motor Recovery After Stroke: An Electrophysiologic Study of Central Motor Pathways
Bastings, Eric; Rapisarda, Giuseppe; Pennisi, Giovanni et al

in Journal of Neurologic Rehabilitation (1997), 11(2), 97-108

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See detail- Purification and characterization of tomato leaf (Lycopersicon esculentum Mill.) hydroperoxide lyase.
Fauconnier, Marie-Laure ULg; Perez, A. G.; Sanz, C. et al

in Journal of Agricultural and Food Chemistry (1997), 45(11), 4232-4236

Hydroperoxide lyase (HPOOH lyase) was extracted from tomato leaves (Lycopersicon esculentum Mill.) and purified to apparent homogeneity by fractionated precipitation with polyethylene glycol 6000, ion ... [more ▼]

Hydroperoxide lyase (HPOOH lyase) was extracted from tomato leaves (Lycopersicon esculentum Mill.) and purified to apparent homogeneity by fractionated precipitation with polyethylene glycol 6000, ion exchange chromatography, and ultrafiltration. The enzyme is a trimer of 73 000 Da units with a molecular mass of 216 000 (determined by native-PAGE and gel filtration); its pI is around 4.9. Enzyme activity measurments realized with 9- and 13-hydroperoxides of linoleic acid (9-La OOH and 13-La OOH, respectively), R-linolenic acid (9-Ln OOH and 13-Ln OOH, respectively), and ç-linolenic acid (9-çLn OOH and 13-ç-Ln OOH, respectively) revealed a great affinity for 13-Ln OOH. The enzyme is rapidly inhibited by its substrate (13-Ln OOH), but preincubation with the other five hydroperoxides, which are not degraded by the enzyme, also resulted in activity inhibition. Dialysis could not restore the activity. When 13-Ln OOH is reduced in its corresponding alcohol or converted to its methyl ester, the inhibition is reduced. [less ▲]

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See detailImage du mois. Syncope vasovagale en direct.
Scheen, André ULg; Marchand, Monique ULg; Juchmes, J.

in Revue Médicale de Liège (1997), 52(5), 315

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See detailPostoperative spirometry after laparoscopy for lower abdominal or upper abdominal surgical procedures.
Joris, Jean ULg; Kaba, Abdourahmane ULg; Lamy, Maurice ULg

in British Journal of Anaesthesia (1997), 79(4), 422-6

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation ... [more ▼]

In this prospective study, we have compared women undergoing laparoscopic cholecystectomy, laparoscopic gynaecological surgery and laparoscopic minor gynaecological procedures (diagnostic, tubal, ligation) (n = 10 in each group) to determine if lower abdominal laparoscopy results in less postoperative pulmonary dysfunction than upper abdominal laparoscopy. Pulmonary testing was performed before operation, and 3 and 6 h after operation, on the first and second days after surgery. After operation, a significant reduction in forced vital capacity, forced expiratory volume in 1 s and peak expiratory flow rate occurred after laparoscopic cholecystectomy at each time. There were no significant changes after minor gynaecologic laparoscopy, whereas laparoscopic gynaecological surgery resulted in minor pulmonary dysfunction on the day of surgery only. We conclude that postoperative pulmonary function was less impaired after gynaecological laparoscopy than after laparoscopic cholecystectomy. This study suggests that the site of surgery is an important determinant of lung dysfunction after laparoscopy. [less ▲]

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See detailIntellectuels malgré eux
Denis, Benoît ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1997), (79-81), 49-52

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See detailPositron emission tomography in parkinsonism
Salmon, Eric ULg

in Acta Neurologica Belgica (1997), 97(3), 187-191

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See detailSaisie-arrêt et concours des créanciers: fin d'une controverse, note sous Cass. (1ère ch.), 11 avr. 1997
Georges, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailPlasma bovine pregnancy-associated glycoprotein concentrations throughout gestation in relationship fetal number in the cow
Patel, Osman V; Sulon, Joseph ULg; Beckers, Jean-François ULg et al

in European Journal of Endocrinology (1997), 137

This study characterized the peripheral plasma bovine pregnancy-associated glycoprotein (bPAG) profile throughout gestation and examined the effect of stage of gestation and fetal number on this profile ... [more ▼]

This study characterized the peripheral plasma bovine pregnancy-associated glycoprotein (bPAG) profile throughout gestation and examined the effect of stage of gestation and fetal number on this profile in Holstein cows after non-surgical embryo transfer. Cows (n = 12) were divided into three groups: group 1 = normal singleton pregnancies (n = 5); group 2 = normal twin pregnancies (n = 5); group 3 = abnormal twin pregnancies (n = 2). Blood was collected about every third day from day 0 (defined as the first day of standing estrus), then daily for the last 10 days of gestation, and sampling was stopped one day postpartum. The time-related changes in plasma bPAG concentrations were significantly (P < 0.01) affected by the stage of gestation and fetal number (P < 0.01), except during the last 10 days of gestation. In both normal pregnancy groups, bPAG concentration increased rapidly during the first trimester (0.5 +/- 0.1 to 14.6 +/- 1.7 ng/ml and 1.0 +/- 0.6 to 21.8 +/- 4.8 ng/ml, in singleton and twin-bearing groups respectively), then progressively between days 160 and 20 prepartum (31.6 +/- 6.2 to 114.3 +/- 31.3 ng/ml and 41.6 +/- 7.4 to 155.8 +/- 36.6 ng/ml in singleton and twin-bearing cows respectively). The mean concentration between days 20 and 10 prepartum approximately tripled (P < 0.001) in both these groups of cows (114.3 +/- 31.1 to 493.0 +/- 75.3 ng/ml and 155.8 +/- 36.6 to 409.3 +/- 114.7 ng/ml in singleton and twin-bearing cows respectively), but between days 10 prepartum and parturition the values increased about threefold (P < 0.01) in the singleton group (493.0 +/- 75.3 to 1352.8 +/- 286.5 ng/ml) and fivefold (P < 0.001) in the twin-bearing group (409.3 +/- 114.7 to 2154.0 +/- 505.7 ng/ml). The two cows in group 3 that gave birth prematurely to a stillborn calf or to a schistosomus reflexus calf exhibited an aberrant bPAG profile. Our results indicate that peripheral bPAG concentrations are correlated to the stage of gestation and fetal number, and that the profile of the peripheral plasma concentrations provides a useful indication of the feto-placental status. [less ▲]

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See detailBovine herpesvirus type 4. In Lymphotropicherpesviruses: Epstein-Barr virus and Human herpesvirus 8
Thiry, Etienne ULg; Lomonte, P.; Vanderplasschen, Alain ULg et al

in International Agency for research on cancer (1997)

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailOxydation photochimique de lixiviats de décharge
Deswaef, Sophie; Baidak, Alexandre; Crine, Michel ULg

in Tribune de l'Eau (La) (1997), 590-591

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See detailSite-directed mutagenesis of glutamate 166 in two beta-lactamases. Kinetic and molecular modeling studies.
Guillaume, Gilliane; Vanhove, M; Lamotte-Brasseur, J et al

in Journal of Biological Chemistry (1997), 272(9), 5438-44

The catalytic pathway of class A beta-lactamases involves an acyl-enzyme intermediate where the substrate is ester-linked to the Ser-70 residue. Glu-166 and Lys-73 have been proposed as candidates for the ... [more ▼]

The catalytic pathway of class A beta-lactamases involves an acyl-enzyme intermediate where the substrate is ester-linked to the Ser-70 residue. Glu-166 and Lys-73 have been proposed as candidates for the role of general base in the activation of the serine OH group. The replacement of Glu-166 by an asparagine in the TEM-1 and by a histidine in the Streptomyces albus G beta-lactamases yielded enzymes forming stable acyl-enzymes with beta-lactam antibiotics. Although acylation of the modified proteins by benzylpenicillin remained relatively fast, it was significantly impaired when compared to that observed with the wild-type enzyme. Moreover, the E166N substitution resulted in a spectacular modification of the substrate profile much larger than that described for other mutations of Omega-loop residues. Molecular modeling studies indicate that the displacement of the catalytic water molecule can be related to this observation. These results confirm the crucial roles of Glu-166 and of the "catalytic" water molecule in both the acylation and the deacylation processes. [less ▲]

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See detailLes téléports en Europe: état actuel et perspectives offertes par les "call centers"
Jacob, Damien ULg

in Revue Géographique de l'Est (1997), 37(4), 273-284

De manière à répondre à l'accroissement de l'offre et de la demande en télécommunications d'entreprises constaté ces dernières années, trois grandes catégories de téléports proposant des services à coûts ... [more ▼]

De manière à répondre à l'accroissement de l'offre et de la demande en télécommunications d'entreprises constaté ces dernières années, trois grandes catégories de téléports proposant des services à coûts partagés et les téléports " hub ", concentrant les flux de communication en un point central. Les téléports ciblent des entreprises exigeant un haut niveau de services en télécommunications, par exemple les centres d'appels téléphoniques. Cette activité, en pleine expansion en Europe, recherche une main-d'œuvre multilingue pouvant assurer par téléphone des services d'information, de conseil, de vente et d'après-vente. Les téléports peuvent donc devenir des outils attractifs pour attirer ce créneau particulièrement porteur en création d'emplois, même si ces derniers sont pour une bonne part une transformation d'anciennes tâches et paraissent potentiellement faciles à délocaliser vers des pays à faible coût du travail. [less ▲]

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See detailA modification of convex approximation methods for structural optimization
Zhang, Wei-Hong; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 89-95

The most popular convex approximation methods used today in structural optimization are discussed in this paper: the convex linearization method (CONLIN), the method of the moving asymptotes (MMA) and the ... [more ▼]

The most popular convex approximation methods used today in structural optimization are discussed in this paper: the convex linearization method (CONLIN), the method of the moving asymptotes (MMA) and the sequential quadratic programming method (SQP). Modifications are made to enhance the reliability of the CONLIN method. In addition, a generalized MMA (GMMA) is established. However, in view of practical difficulties of evaluating second-order derivatives, a fitting scheme is proposed in this work to adjust the convexity of the approximation based on the available function value at the preceding design iteration. Numerical results show that this simple scheme is efficient in our applications. [less ▲]

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailEssai d'utilisation du meloxicam (Metacam® Boehringer Ingelheim) chez le pigeon voyageur
Marlier, Didier ULg; Jonckers, Frédéric; Vindevogel, Henri ULg

in Annales de Médecine Vétérinaire (1997), 141

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See detailMorphological alterations of blood platelets induced by Platelet Activating Factor (PAF) and partial inhibition by Ketoprofen in calves
Bastos da Silva, Miriam; Doizé, Cécile ULg; David, Jean-Louis ULg et al

in Veterinary Research (1997), 28(5 Sep-Oct), 489-502

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen ... [more ▼]

The influence of platelet activating factor (PAF) was investigated in vivo on the ultrastructure of bovine platelets, and on the platelet count. The effect of an intravenous administration of ketoprofen (a non-steroidal anti-inflammatory drug) pretreatment followed by PAF infusion was also observed in a group of six healthy male Friesian calves. PAF infusion alone caused a moderate thrombocytopenia, which peaked one minute post challenge and returned to levels not significantly different from control after 30 min. Electron microscopy revealed that after PAF infusion, platelets lost their lentiform shape and became irregular, with many pseudopods. Their microtubules became impossible to distinguish. The numbers of alpha granules and dense bodies were significantly decreased. Glycogen particles became rare or even disappeared. Giant platelets occasionally appeared. The Golgi apparatus was more often visible and the number of mitochondria was significantly increased. Ketoprofen pretreatment lowered PAF-induced thrombocytopenia and decrease in the number of dense bodies. Under these conditions, the Golgi apparatus was rarely visible and giant platelets were not observed. These results showed that the morphological ultrastructure of blood platelets in bovines were modified following PAF infusion and that ketoprofen pretreatment before PAF infusion provided partial protection, limiting the extent of the morphological alterations and maintaining a normal platelet count [less ▲]

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See detailThe Photoabsorption Spectrum of Vinylchloride (C2H3Cl) in the 8-12 eV Range.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg ... [more ▼]

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg transitions have been identified and classified. Tentative assignments were based on the ionization energies as measured by He(I)- and threshold photoelectron spectroscopy, as reported in the joined paper. Many features have been identified as being members of vibrational progressions belonging to the observed Rydberg series. [less ▲]

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See detailAménagement et gestion des territoires : essai de bilan des recherches françaises
Merenne-Schoumaker, Bernadette ULg

in Intergeo Bulletin (1997), 128

Review of research funded by the CNRS within the framework of Section "Spaces, Territories, Societies"

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See detailL'AMDP appliqué à des réfugiés de Croatie
Mormont, Christian ULg

in Acta Psychiatrica Belgica (1997), 97(1), 55-60

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See detailSpecific repertoire of olfactory receptor genes in the male germ cells of several mammalian species
Vanderhaeghen, P.; Schurmans, Stéphane ULg; Vassart, G. et al

in Genomics (1997), 39

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the ... [more ▼]

Olfactory receptors constitute the largest family among G protein-coupled receptors, with up to 1000 members expected. We have previously shown that genes belonging to this family were expressed in the male germ line from both dog and human. We have subsequently demonstrated the presence of one of the corresponding olfactory receptor proteins during dog spermatogenesis and in mature sperm cells. In this study, we investigated whether the unexpected pattern of expression of olfactory receptors in the male germ line was conserved in other mammalian species. Using reverse transcription-PCR with primers specific for the olfactory receptor gene family, about 20 olfactory receptor cDNA fragments were cloned from the testis of each mammalian species tested. As a whole, they displayed no sequence specificity compared to other olfactory receptors, but highly homologous, possibly orthologous, genes were amplified from different species. Finally, their pattern of expression, as determined by RNase protection assay, revealed that many but not all of these receptors were expressed predominantly in testis. The male germ line from each mammalian species tested ins thus characterized by a specific repertoire of olfactory receptors, which display a pattern of expression suggestive of their potential implication in the control of sperm maturation, migration, or fertilization [less ▲]

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See detailA novel seizure-induced synaptotagmin gene identified by differential display.
Babity, J. M.; Armstrong, J. N.; Plumier, Jean-Christophe ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2638-41

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of ... [more ▼]

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fragment expressed in the degenerating hippocampus and piriform cortex, but not in the nondegenerating parietal cortex, was identified, cloned, and sequenced. This novel cDNA fragment identified a new member of the synaptotagmin gene family that is rapidly and transiently induced in response to seizure activity. Differential expression of this synaptotagmin gene, syt X, was confirmed by Northern blot analysis and in situ hybridization. This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function. [less ▲]

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See detailPsychrophiles et thermophiles : un problème d’enzyme
Gerday, Charles ULg; Aittaleb, M.; Arpigny, J. L. et al

in Chimie Nouvelle (1997), 15

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See detailInfluence of cholesterol on survival after stroke. Cholesterol may be marker of inflammation.
VALDES SOCIN, Hernan Gonzalo ULg

in BMJ (Clinical Research ed.) (1997), 315(7116), 1159

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See detailEtude histologique de lésions subcliniques de la lèvre latérale du talus chez le cheval
Yousfi, S.; Gabriel, Annick ULg; Maroit, V. et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailLa responsabilité civile et professionnelle des administrateurs
Caprasse, Olivier ULg

in Actualités du Droit (1997)

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Percentile (1997), 2

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See detailSelection of lumped parameter models to characterize vascular properties of pulmonary circulation
LAMBERMONT, Bernard ULg; GERARD, P; DETRY, Olivier ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailThe Spectrum of Ne V
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Physica Scripta (1997), 55

A new investigation of the Ne V spectrum is reported. The beam-foil method has been used to produce spectra at two different energies (1.2 MeV and 2.5 MeV) between 450 and 11OOA Sixty-five lines of Ne V ... [more ▼]

A new investigation of the Ne V spectrum is reported. The beam-foil method has been used to produce spectra at two different energies (1.2 MeV and 2.5 MeV) between 450 and 11OOA Sixty-five lines of Ne V have been newly identified. Fifty levels have been determined for the first time and energies have been revised for seven levels. [less ▲]

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See detailLinear Benard-Marangoni instability in rigid circular containers
Dauby, Pierre ULg; Lebon, Georgy ULg; Bouhy, E.

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 56(1), 520-530

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See detailThe Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Research Communications (1997), 21(7), 521-531

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet ... [more ▼]

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. [less ▲]

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See detailLa tertiarisation des parcs d’activités économiques en Région wallonne
Devillet, Guénaël ULg

in Wallonie (1997), 24(49), 35-44

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See detailElectron partitioning between the two branching quinol-oxidizing pathways in Acanthamoeba castellanii mitochondria during steady-state state 3 respiration.
Jarmuszkiewicz, W.; Sluse-Goffart, C.; Hryniewiecka, L. et al

in Journal of Biological Chemistry (1997), 273(17), 10174-10180

Amoeba mitochondria possess a respiratory chain with two quinol-oxidizing pathways: the cytochrome pathway and the cyanide-resistant alternative oxidase pathway. The ADP/O method, based on the non ... [more ▼]

Amoeba mitochondria possess a respiratory chain with two quinol-oxidizing pathways: the cytochrome pathway and the cyanide-resistant alternative oxidase pathway. The ADP/O method, based on the non-phosphorylating property of alternative oxidase, was used to determine contributions of both pathways in overall state 3 respiration in the presence of GMP (an activator of the alternative oxidase in amoeba) and succinate as oxidizable substrate. This method involves pair measurements of ADP/O ratios plus and minus benzohydroxamate (an inhibitor of the alternative oxidase). The requirements of the method are listed and verified. When overall state 3 respiration was decreased by increasing concentrations of n-butyl malonate (a non-penetrating inhibitor of succinate uptake), the quinone reduction level declined. At the same time, the alternative pathway contribution decreased sharply and became negligible when quinone redox state was lower than 50%, whereas the cytochrome pathway contribution first increased and then passed through a maximum at a quinone redox state of 58% and sharply decreased at a lower level of quinone reduction. This study is the first attempt to examine the steady-state kinetics of the two quinol-oxidizing pathways when both are active and to describe electron partitioning between them when the steady-state rate of the quinone-reducing pathway is varied. [less ▲]

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See detailUltrastructural nucleolar alterations induced by an ametantrone/polyr(A-U) complex.
Thiry, Marc ULg; Jamison, J. M.; Gilloteaux, J. et al

in Experimental Cell Research (1997), 236(1), 275-84

In the present study we examined the ultrastructural modifications as well as the precise distribution of DNA and RNA in RT4 cell nucleoli following a 3-h exposure to nontoxic or toxic doses of ... [more ▼]

In the present study we examined the ultrastructural modifications as well as the precise distribution of DNA and RNA in RT4 cell nucleoli following a 3-h exposure to nontoxic or toxic doses of ametantrone (AMT), poly(adenylate-uridylate) (polyr(A-U), or an AMT/polyr(A-U) combination. While distribution of nucleic acids within the various nucleolar components is not modified following all treatments, the nucleoli exhibit several ultrastructural changes: redistribution of the nucleolar components, decrease in the number of fibrillar centers, and increase in the size of the fibrillar centers. The relative frequencies of the test agents to induce the apparition of nucleoli of compact type are AMT/polyr(A-U) > AMT approximately polyr(A-U) > sham-treated, while the abilities of the test agents to induce the nucleolar segregation are AMT/polyr(A-U) approximately AMT > polyr(A-U) > sham-treated cells. These ultrastructural changes are characteristics of drugs that intercalate into DNA and inhibit rDNA transcription as well as rRNA processing and release of nascent preribosomes from the nucleolus. [less ▲]

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See detailEtat de nécessité et damnum incendii arcendi causa datum
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (1997), 44

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See detailAnaesthesia for thoracoscopic surgery
Larbuisson, Robert ULg; Lamy, Maurice ULg

in Current Opinion in Anaesthesiology (1997), 10

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See detailRecherche d'information et pragmatisme : II. Utilité sociale de la confirmation d'hypothèses
Dardenne, Benoît ULg; Leyens, J.; Yzerbyt, V. Y.

in Année Psychologique (L') (1997), 97

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See detailA moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis.
Cazzola, M.; Borgna-Pignatti, C.; Locatelli, F. et al

in Transfusion (1997), 37(2), 135-40

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is ... [more ▼]

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is frequently associated with manifestations of transfusion iron overload, despite regular chelation therapy with subcutaneous desferoxamine. STUDY DESIGN AND METHODS: To verify whether a transfusion regimen with a target pretransfusion hemoglobin level between 9 and 10 g per dL can allow a significant reduction in blood consumption, while still effectively suppressing erythropoiesis, the records were reviewed of 32 beta-thalassemia major patients, who were maintained at a pretransfusion hemoglobin of 11.3 +/- 0.5 g per dL between 1981 and 1986. These patients were switched at the beginning of 1987 to a transfusion regimen with pretransfusion hemoglobin of 9.4 +/- 0.4 g per dL. The degree of erythroid marrow activity was evaluated in these patients and in 32 subjects with beta-thalassemia intermedia through the simple measurement of serum transferrin receptor. RESULTS: After the adoption of the moderate transfusion regimen, transfusion requirements decreased from 137 +/- 26 to 104 +/- 23 mL per kg per year of red cells (p < 0.0001), and mean serum ferritin decreased from 2448 +/- 1515 to 1187 +/- 816 micrograms per L (p < 0.0001), with one-half of patients achieving serum ferritin levels lower than 1000 micrograms per L. The proportion of patients having spontaneous pubertal development increased significantly (p < 0.01), as a result of less iron-related gonadotropin insufficiency. At the lower pretransfusion hemoglobin, erythroid marrow activity did not exceed two to three times normal levels in most subjects. CONCLUSION: As compared with hypertransfusion, moderate transfusion may allow more effective prevention of iron loading, with higher likelihood of spontaneous pubertal development and without producing excessive expansion of erythropoiesis. [less ▲]

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See detailSpectroscopy of Ne IV in the wavelength Range 450–1100 Å
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Journal of the Optical Society of America. B, Optical Physics (1997), 14

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution ... [more ▼]

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution that was achieved, with a normal-incidence 2-m spectrometer, was sufficient to identify 53 new Ne IV lines and, consequently, to determine 18 new levels in the quartet and doublet systems and one sextet term. The energy values of 13 additional levels were also revised. The classification work was facilitated by the use of scaled relativistic Hartree–Fock calculations. [less ▲]

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See detailThéorie de l'approche hydrogéologique des écoulements et transports en zone partiellement saturée
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1997), 119(1), 71-89

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See detailAssociative chunk strength in artificial grammar learning
Meulemans, Thierry ULg; Van der Linden, Martial ULg

in Journal of Experimental Psychology. Learning, Memory & Cognition (1997), 23(4), 1007-1028

In four experiments, adherence to grammatical rules and associative chunk strength (including different measures, each calculated on the basis of the frequency with which bigrams and trigrams present in ... [more ▼]

In four experiments, adherence to grammatical rules and associative chunk strength (including different measures, each calculated on the basis of the frequency with which bigrams and trigrams present in the test strings appeared in the learning strings) were manipulated independently in the test phase of an artificial grammar learning task. When participants learned few items of the grammar (Experiments 1a and 2a), the associated items were more often classified as grammatical than the nonassociated ones. On the other hand, when the learning phase included most of the grammatical items (Experiments 1b and 2b), the only effect observed was an effect of grammaticality. These results suggest that, depending on the specific constraints of the tasks, knowledge based on bigrams and trigrams and knowledge based on the abstraction of the grammatical structure can be used for the classification task. [less ▲]

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See detailStructural And Functional Properties Of The 154-171 Wild-Type And Variant Peptides Of Human Lecithin-Cholesterol Acyltransferase
Peelman, F.; Goethals, M.; Vanloo, B. et al

in European Journal of Biochemistry (1997), 249(3), 708-15

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment ... [more ▼]

The 154-171 segment of the human lecithin-cholesterol acyltransferase (LCAT) enzyme was identified as the most stable amphipathic helix in the LCAT sequence. Its mean hydrophobicity, hydrophobic moment and its orientation at a lipid/water interface are similar to those of some of the helical repeats of apolipoprotein A-IV and E. This domain was therefore proposed as a candidate peptide accounting for the association between LCAT and its lipid substrate. To investigate this hypothesis we synthesized the LCAT-(154-171)-peptide, two variants containing the natural Y156N and R158C mutations and a variant with increased hydrophobicity through Y156I, L160I, L163I and Y171W substitutions. The structural and lipid-binding properties of these synthetic peptides were investigated by turbidity, fluorescence, electron microscopy and circular dichroism. The wild-type peptide, the R158C variant in its dimeric form, as well as the more hydrophobic peptide, associated with phospholipids, whereas the Y156N and the R158C variant in its monomeric form did not. However, only the complexes generated with the hydrophobic variant were stable enough to resist dissociation during gel filtration. The wild-type peptide and hydrophobic variant formed discoidal complexes with dimyristoylglycerophosphocholine (Myr2GroPCho) as shown by negative staining electron microscopy. Comparison of the properties of the wild-type and hydrophobic variant LCAT-(154-171)-peptide stresses the contribution of the hydrophobic face of the amphipathic helix to the formation and stabilization of the peptide/lipid complexes. This is further confirmed by the decreased affinity of the Y156N variant peptide for lipids, as this mutation decreased the mean hydrophobicity of the hydrophobic face of the amphipathic helix. These results support the hypothesis that the 154-171 segment of LCAT might be involved in the interaction of the enzyme with its lipid substrate and suggest that the decreased activity of the Y156N natural LCAT mutant might result from a decreased affinity of this mutant for lipids. [less ▲]

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See detailFibres alimentaires chez le chien : influence de l'incorporation de pulpes de betterave ou de chicorée sur la digestibilité des nutriments et les concentrations plasmatiques de plusieurs métabolites
Diez, Marianne ULg; Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg et al

in Revue de Médecine Vétérinaire (1997), 148

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres ... [more ▼]

Cette étude relate les effets de la distribution de deux rations enrichies en pulpes de betterave ou de chicorée (7 p.100 ADF dans la matière sèche) en comparaison à une ration témoin sur les paramètres fécaux, la digestibilité des principaux nutriments et plusieurs paramètres biochimiques (glucose, insuline, azote alpha-aminé, urée, cholestérol et triglycérides) mesurés à jeun ou pendant six heures après le repas chez huit chiens adultes en bonne santé. Les régimes enrichis en pulpes ont entraîné une augmentation significative de l'excrétion fécale totale, de l'excrétion de MS dans les matières fécales, une diminution de la teneur en MS des fèces ainsi qu'une diminution des coefficients de digestibilité des principaux nutriments. Le régime contenant la pulpe de betterave a entraîné une diminution de la glycémie à jeun, de l'insulinémie et des concentrations en triglycérides postprandiales, des concentrations en urée et en cholestérol mesurées avant et après le repas. Le régime contenant la pulpe de chicorée a provoqué une diminution de l'insulinémie postprandiale, des concentrations en urée et en cholestérol à jeun et après le repas. Ces deux types de pulpes, semblables par leur composition, induisent les mêmes types d'effets sur les paramètres fécaux et la digestibilité des nutriments, mais les effets systémiques sont plus importants lors de la distribution de pulpes de betterave. [less ▲]

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See detailEffect of bi-level positive airway pressure (BiPAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty.
Joris, Jean ULg; Sottiaux, Thierry; Chiche, Jean-Daniel et al

in CHEST (1997), 111(3), 665-70

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines ... [more ▼]

STUDY OBJECTIVE: Upper abdominal surgery results in a postoperative restrictive pulmonary syndrome. Bi-level positive airway pressure (BiPAP System; Respironics Inc; Murrysville, Pa), which combines pressure support ventilation and positive end-expiratory pressure via a nasal mask, could allow alveolar recruitment during inspiration and prevent expiratory alveolar collapse, and therefore limit the postoperative pulmonary restrictive syndrome. This study investigated the effect of BiPAP on postoperative pulmonary function in obese patients after gastroplasty. DESIGN: Prospective controlled randomized study. SETTING: GI surgical ward in a university hospital. PATIENTS: Thirty-three morbidly obese patients scheduled for gastroplasty were studied. INTERVENTION: The patients were assigned to one of three techniques of ventilatory support during the first 24 h postoperatively: O2 via a face mask, BiPAP System 8/4, with inspiratory and expiratory positive airway pressure set at 8 and 4 cm H2O, respectively, or BiPAP System 12/4 set at 12 and 4 cm H2O. Pulmonary function (FVC, FEV1, and peak expiratory flow rate [PEFR]) were measured the day before surgery, 24 h after surgery, and on days 2 and 3. Oxygen saturation by pulse oximeter (SpO2) was also recorded during room air breathing. RESULTS: Three patients were excluded. After surgery, FVC, FEV1, PEFR, and SpO2 significantly decreased in the three groups. On day 1, FVC and FEV1 were significantly improved in the group BiPAP System 12/4, as compared with no BiPAP; SpO2 was also significantly improved. After removal of BiPAP System 12/4, these benefits were maintained, allowing faster recovery of pulmonary function. No significant effects were observed on PEFR. BiPAP System 8/4 had no significant effect on the postoperative pulmonary restrictive syndrome. CONCLUSION: Prophylactic use of BiPAP System 12/4 during the first 24 h postoperatively significantly reduces pulmonary dysfunction after gastroplasty in obese patients and accelerates reestablishment of preoperative pulmonary function. [less ▲]

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See detailLa vaccination contre les hépatites A et B
Delwaide, Jean ULg; Belaiche, Jacques ULg

in Revue Médicale de Liège (1997), 52(10), 639-643

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See detailProduction and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cells
Devy, L.; Noël, Agnès ULg; Baramova, E. et al

in Biochemical and Biophysical Research Communications (1997), 238

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]

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See detailPost-operative adjuvant therapy for non-small-cell lung cancer
Barthelemy, Nicole ULg; Johnson; Arriagada et al

in Lung Cancer (1997), 17(supp 1),

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See detailFatty acid hydroperoxides pathway in plants. A review
Fauconnier, Marie-Laure ULg; Marlier, M.

in Grasas y Aceites (1997), 48(1), 30-37

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is ... [more ▼]

The present paper focusses on the fatty acid hydroperoxides pathways, mainly hydroperoxide lyase and hydroperoxide dehydrase. For each enzyme, the definition, occurrence and subcellular localization is presented. Particular attention is given to reaction mecanisms and to substrate specificity. Physiological roles of reaction products are also discussed. [less ▲]

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See detailCompte rendu de l'ouvrage de Th. Bardinet, Les papyrus médicaux de l'Egypte pharaonique, Paris, 1995
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1997), 47(139 bis), 139-141

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See detailImprovement of inland navigation in developping countries: the training center of Palembang (Sumatra, Indonesia), an example of transfer of technology through education
Marchal, Jean ULg

in Bulletin des Séances de l’Académie Royale des Sciences d’Outre-Mer = Mededelingen der Zittingen van de Koninklijke Academie voor Overzeese Wetenschappen (1997), Nouvelle Série 42(4)(1er trimestre), 10

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See detailL'abord coelioscopique des pheochromocytomes est-il acceptable? Reflexions a propos d'une etude prospective de 6 cas personnels.
Hamoir, Etienne ULg; Defechereux, Thierry ULg; Nguyen Dang, Delphine ULg et al

in Annales d'Endocrinologie (1997), 58(1), 65-74

Today, laparoscopy is for us the technique of choice for approaching presumed benign adrenal tumors. With regards to pheochromocytoma however, two major questions must be addressed. First, is it ... [more ▼]

Today, laparoscopy is for us the technique of choice for approaching presumed benign adrenal tumors. With regards to pheochromocytoma however, two major questions must be addressed. First, is it acceptable to resect potentially multifocal tumors with such a targeted approach? Second, can peroperative hemodynamic changes be anticipated and controlled by the anesthetist, taking into account the additional effects of pneumoperitoneum and catecholamine release on the cardiovascular system? The present prospective study attempts to answer these two questions. From November 1993 to November 1995 we operated on four women and two men, with ages ranging from 33 to 71 years (mean of 47) and a mean Body Mass Index of 25 kg/m2 (range 17-35). Four patients were assigned ASA (American Society of Anesthesiologists) physical status 2, one grade 1 and one grade 3. Comprehensive preoperative work-up, including a CT scan and an I131 MIBG Scan in all, a C11 Hydroxyephedrine PET Scan in 4 and a MRI in one patient, showed a solitary lesion in each case. There were four right-sided and two left-sided tumors, ranging from 30 to 60 mm in diameter. Laparoscopy was always performed transperitoneally. Systemic and pulmonary hemodynamics were thoroughly assessed. Epinephrin and norepinephrin concentrations were measured at the 10 key-time of surgery. Use of continuous intravenous infusion of nicardipine allowed tight control of hemodynamics despite impressive increases in circulating catecholamines. The mean operative time was 76 minutes (range 59-130). Blood loss was minimal. We observed neither mortality nor morbidity. Mean hospital stay ranged from 3 to 13 days (median = 3). All patients are normotensive without drug after a follow-up of 9 to 33 months. In conclusion, we think that laparoscopic removal of selected cases of pheochromocytoma may be performed safely from both the hemodynamical and oncological standpoints. [less ▲]

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See detailFeeding of the sparid fish Sarpa salpa in a seagrass ecosystem: Diet and carbon flux
Havelange, S.; Lepoint, Gilles ULg; Dauby, Patrick ULg et al

in Marine Ecology (1997), 18(4), 289-297

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ... [more ▼]

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ratios were measured in fish muscle and potential food sources (algae, P. oceanica leaf and its epiphytes) to determine their relative contribution to the fish diet. S. salpa has an age-related mixed diet: juveniles are plankton feeders, young, sub-adults and adults are herbivorous, and, the older the individuals, the higher the relative contribution of P. oceanica to the diet. Our results and former studies of carbon stocks and fluxes in the P. oceanica bed of Revellata Bay have enabled an estimation of the general impact of S. salpa grazing on infralittoral communities: the studied species consumes 24 g C.m-2.a(-1) from P. oceanica leaf, 4.8 from epiphytes and 13 from epilithic algae. The fish net production and biomass turnover in that zone have been estimated to be 1.2 g C.m(-2).a(-1) and 1.5 a(-1), respectively. [less ▲]

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See detailRegolazione della crescité follicolare e luteinica. Ovulazione, corpo luteo e luteolisi. Summa.
Drion, Pierre ULg; Ectors, F. J.; Hanzen, Christian ULg et al

in Riproduzione dei ruminanti (1997), 14(9), 17-25

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See detail1897-1997 Les cent ans de la section des Eaux et Forêts
Rondeux, Jacques ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(4), 236-238

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See detailThe role of bisphosphonates in the treatment of osteoporosis
Reginster, Jean-Yves ULg; Halkin, V.; Gosset, Christiane ULg et al

in Drugs of Today (Barcelona, Spain : 1998) (1997), 33

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See detailLe concept de qualité de vie
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Francophone de Clinique Comportementale et Cognitive (1997), II(3), 16-25

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la ... [more ▼]

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la multifactorialité, l'auto-évaluation, la variabilité temporelle et la subjectivité. De plus, l'étude comparative des multiples outils existants devrait permettre d'affiner leur spécificité et donc aider à la compréhension du concept... [less ▲]

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See detailTwo centuries of vaccination
Vanderplasschen, Alain ULg; Smith, G. L.

in Annales de Médecine Vétérinaire (1997), 141

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See detailWhat Is the Risk of Transferral of an Undetected Neoplasm During Organ Transplantation?
Detry, Olivier ULg; Bonnet, Pierre ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (1997), 29(5), 2410-1

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See detailSIME: A hybrid approach to fast transient stability assessment and contingency selection
Zhang, Ywee; Wehenkel, Louis ULg; Rousseaux, Patricia ULg et al

in International Journal of Electrical Power & Energy Systems (1997), 19(3), 195-208

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME ... [more ▼]

We propose an integrated scheme for transient stability assessment which in a sequence screens contingencies and scrutinizes only the selected ones. This scheme is based on a hybrid method, called SIME for Single Machine Equivalent. SIME relies on a particular direct method coupled with time-domain programs so as to combine the strengths of both, namely: the flexibility with respect to power system modelling of time-domain methods; the speed and richer information of the direct method. This paper lays the foundations of SIME, devises appropriate techniques for transient stability assessment per se and for contingency screening, and finally integrates these two techniques in a fully general function, i.e. able to comply with any power system modelling and stability scenario, and to assess any type of stability limits (critical clearing times or power limits). Throughout, real-world examples illustrate the proposed techniques and highlight their performances. [less ▲]

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See detailPalladium-silver sol-gel catalysts for selective hydrodechlorination of 1,2-dichloroethane into ethylene - I. Synthesis and characterization
Heinrichs, Benoît ULg; Delhez, Patrice; Schoebrechts, Jean-Paul et al

in Journal of Catalysis (1997), 172(2), 322-335

Low-density xerogel Pd-Ag/SiO2 catalysts were prepared by a cogelation of tetraethoxysilane with organically substituted alkoxides capable of forming chelates with palladium and silver ions, followed by a ... [more ▼]

Low-density xerogel Pd-Ag/SiO2 catalysts were prepared by a cogelation of tetraethoxysilane with organically substituted alkoxides capable of forming chelates with palladium and silver ions, followed by a drying under vacuum, a calcination, and a reduction. The resulting Pd-Ag alloy particles have diameters of about 2-3 nm and are dispersed inside the silica particles which exhibit a monodisperse micropore size distribution centered at 0.8 nm. At low silver loading, the composition of the bimetallic particles is almost identical to the overall composition, but when this loading is increased, the percentage of silver in the alloy particles is appreciably lower than the overall percentage, In all bimetallic samples, a few large pure silver particles are observed. When dried under vacuum, the xerogels exhibit a texture similar to that of aerogels dried under supercritical conditions with pore volumes in the range 2-6 cm(3)/g and pores ranging from micro- to macropores of several hundred nanometers. When the silver loading is increased, xerogels containing palladium show aggregates of increasingly interpenetrated silica particles. This is explained bq an aggregation, during the gelation reaction, of colliding SiO2 particles which is limited by an increasingly slow sticking reaction due to the growing basicity in the precursor solution when the concentrations of Ag and associated compounds are increased. During thermal treatments, the Pd-Ag alloy seems to form by the migration, through the porous network, of silver which finally alloys with Pd crystallites trapped inside SiO2 particles. Whereas ethane is the main product when hydrodechlorination of 1,2-dichloroethane is performed over pure palladium, the dilution of this active metal by silver leads to a strong increase in ethylene selectivity. (C) 1997 Academic Press. [less ▲]

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See detailTell Amarna 1997
Tunca, Önhan ULg

in Chronique archéologique en Syrie 2 (1997)

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See detailSurveillance of foodborne illnesses in Belgium.
Daube, Georges ULg; Van Look, F.

in Archives of Public Health (1997), 55

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See detailComplexation of uranyl ion by polyvinylimidazole: Electrochemical preparation and leaching tests investigations
Martinot, Lucien; Leroy, D.; Jérôme, Christine ULg et al

in Journal of Radioanalytical & Nuclear Chemistry (1997), 224(1-2), 71-76

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical ... [more ▼]

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical preparation of polyvinylimidazole (PVI) which is a polymer capable of complexing uranyl ions. We confirm the complexation of uranyl ions by PVI in various media by FT-IR and UV-Visible analysis but all these complexes were found to be soluble in water so we put forward new complexes with an additional polymer to shape out insoluble complex. Leaching tests demonstrate the efficiency of our process. [less ▲]

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Vaisseaux, Coeur, Poumons (1997), 2

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See detailDesigning and implementing a GIS in an international context
Pantazis, Dimos N; Cornélis, Bernard ULg

in Transactions in GIS (1997), 1(4), 301-320

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between ... [more ▼]

International collaborations between private companies, national research laboratories, and universities in the field of GIS have opened up new ways of exchanging knowledge and experiences between different countries. However, when a collaboration involves the actual design and implementation of an operational GIS, rather than simply theoretical or applied research, or the development of specific applications, many problems can arise, sometimes leading either to the partial success or the complete failure of the project. Some of these problems are frequently encountered in all kinds of international collaborations: problems arising from different cultural mentalities, difficulties establishing a single common leadership, difficulties with communication and information exchange, and so on. Problems relating to the specific nature of the GIS are also present, for example the absence of digital geographic data format standards, the absence of metadata standards, the omission to use GIS or IS design methods, etc. This paper focuses on a joint Sino-Belgian project for the design and implementation of an urban geographical information system (UGIS) integrating remote sensing techniques in Hangzhou city, China and examines the general, specific, and international aspects of the problems encountered in an international collaboration. [less ▲]

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See detailDissociations between the processing of proper and common names
Brédart, Serge ULg; Brennen, T.; Valentine, T.

in Cognitive Neuropsychology (1997), 14(2), 209-217

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See detailVerapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Diabetologia (1997), 40

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See detailThe lowest 5g-6h supermultiplet of Fe II
Biémont, Emile ULg; Johansson, S.; Palmeri, P.

in Physica Scripta (1997), 55

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