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See detailHypnose, hypnosédation. Conceptions actuelles et leurs applications en chirurgie plastique
Faymonville, Marie-Elisabeth ULg; Fissette, Jean ULg; Mambourg, P. H. et al

in Revue Médicale de Liège (1994), 49(1), 13-22

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See detailEvidence for violent ejection of nebulae from massive stars
Hutsemekers, Damien ULg

in Astronomy and Astrophysics (1994), 281(Letters), 81-84

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central ... [more ▼]

We report the results of a systematic search for nebulae around Luminous Blue Variable LBVs) and the discovery of a strong correlation between the mass of the nebulae and the luminosity of the central stars. This correlation holds for both the dust and ionized gas masses of the nebulae. The existence of a 'nebular mass-stellar luminosity' relation and the fact that not all LBVs are presently associated with a nebula give evidence against a continuous mass-loss mechanism for the formation of these nebulae. Further, the good agreement found between the observed relation and predictions by Maeder (1989), suggests that all these nebulae may be due to a violent ejection of matter caused by an instability of structural origin. [less ▲]

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See detailFurther observational evidence that MG J0414+0534 is a gravitational mirage
Angonin-Willaime, M.-C.; Vanderriest, C.; Hammer, F. et al

in Astronomy and Astrophysics (1994), 281

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the ... [more ▼]

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the (extremely red and almost featureless) spectra of the 2 brightest components are very similar. These are strong indications that the system results from multiple gravitational imaging of a single source, but the nature of this source is not yet clear. It could be the nucleus of a low metallicity galaxy at a high redshift or a new type of object. Significant differences are observed between the flux ratios of the images at radio and optical wavelenghts. The most likely explanation for this effect is a differential amplification of the image pair A[SUB]1[/SUB]-A[SUB]2[/SUB] because of the large magnification gradient near a caustic. [less ▲]

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See detailLe pied diabétique: etiopathogénie, prévention et traitement
Van Damme, Hendrik ULg; Paquet, Philippe ULg; Maertens de Noordhout, B. et al

in Revue Médicale de Liège (1994), 49(1), 1-13

-Le pied diabétique est la conséquence des altérations dégénératives du système vasculonerveux observées dans un diabète de longue durée. La neuropathie diabétique est le facteur essentiel dans la plupart ... [more ▼]

-Le pied diabétique est la conséquence des altérations dégénératives du système vasculonerveux observées dans un diabète de longue durée. La neuropathie diabétique est le facteur essentiel dans la plupart des cas, responsable d'hypoalgésies, microtraumatismes et ulcérations, déformation du pied (amyotrophie), et d'une eutosympethectomie (peau sèche, fissurée). Une macroangiopathie (médiacalcinose, occlusions artérielles périphériques) n'est retrouvée que dans 30 % des cas. Une microangiopathie compromet la trophicité des tissus et ralentit leur cicatrisation. Enfin, tout diabétique présente une susceptibilité élevée aux infections. Cette multitude de facteurs en cause impose des mesures de prévention. Un équilibre du profil glycémique retardera les atteintes vasculo-nerveuses. L'hygiène du pied consistera en bains de pieds, soins d'ongles et d'hyperkératoses, chaussures adaptées. En cas de troubles trophiques, une décharge d'appui sers nécessaire. Une désinfection rigoureuse, associée à une antibiothérapie (après prélèvement, si possible) aidera à éviter l'évolution vers l'abcès profond. La moindre collection sera drainée, après excision large des tissus nécrotiques. Les nécroses sèches (talons, orteils) traduisent souvent une artériopethie, pour laquelle un geste de revascularisation (protondoolestie; pontage distal) pourra être pris en considération. Parfois, l'état septique du patient, ou l'étendue de la gangrène, imposera une amputation. L'approche du pied diabétique doit toujours être multidisciplinaire (diabétologue, dermatologue, orthésiste, orthopédiste, chirurgien vasculaire), et doit commencer par des mesures préventives. [less ▲]

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See detailTransplantations de tumeurs malignes insoupçonnées lors de greffes d'organes
Detry, Olivier ULg; Detroz, Bernard ULg; D'Silva, M. et al

in Revue Médicale de Liège (1994), 49(1), 23-31

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See detailPhotometric variations of Ap stars
Manfroid, Jean ULg; Renson, Pierre ULg

in Astronomy and Astrophysics (1994), 281

The photometric variations of seven Ap stars have been analyzed from observations mainly obtained in the framework of the Long-Term Photometry of Variables project at European Southern Observatory (ESO ... [more ▼]

The photometric variations of seven Ap stars have been analyzed from observations mainly obtained in the framework of the Long-Term Photometry of Variables project at European Southern Observatory (ESO). New values for the periods and detailed light curves in the uvby system are provided. Alpha Scl is shown to display anomalous variations that set it apart from the other stars. [less ▲]

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See detailLong-Term (3 Years) Prevention of Trabecular Postmenopausal Bone Loss with Low-Dose Intermittent Nasal Salmon Calcitonin
Reginster, Jean-Yves ULg; Denis, D.; Deroisy, Rita ULg et al

in Journal of Bone and Mineral Research : The Official Journal of the American Society for Bone and Mineral Research (1994), 9(1), 69-73

The long-term effect of intermittent low-dose nasal salmon calcitonin on trabecular early postmenopausal bone loss was assessed as follow-up to a previously published study. Randomized controlled group ... [more ▼]

The long-term effect of intermittent low-dose nasal salmon calcitonin on trabecular early postmenopausal bone loss was assessed as follow-up to a previously published study. Randomized controlled group comparison was made of 287 healthy women with 6-36 months of natural menopause and no treatment interfering with calcium metabolism at an outpatient clinic for research in bone and cartilage metabolism. The 287 women were randomly allocated to 3 years of treatment with either 500 mg/day, 5 days/week of calcium or the same amount of calcium plus 50 IU/day, 5 days per week of nasal salmon calcitonin. A total of 186 women complied with the study protocol throughout. The main outcome measures were bone mineral density of the lumbar spine (DPA) and biochemical parameters reflecting bone turnover (serum alkaline phosphatases, urinary calcium/creatinine, and hydroxyproline/creatinine ratio). The average changes in bone mineral density after 36 months showed a positive (p < 0.05) outcome (1.8 +/- 5.7%; mean +/- SD) in the group treated with salmon calcitonin and calcium and a significant (p < 0.01) loss (-5.8 +/- 4.8%) in patients receiving calcium alone. The difference between the evolution of the two groups was significantly (p < 0.01) different after 6 months of treatment and remained so until the end of the study. No significant changes were recorded in biochemical parameters reflecting bone turnover. As previously shown during a 1 year follow-up, nasal salmon calcitonin given at low dose and intermittently, in association with calcium, can counteract trabecular postmenopausal bone loss. [less ▲]

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See detailLe point sur la production d’embryons in vitro: limitations et perspectives de la recherche
Thonon, Fabienne; Ectors, Fabien ULg; Delval, Alain et al

in Annales de Médecine Vétérinaire (1994), 138(1), 33-40

Recent progress in gamete biology and early embryo development was responsible for great evolution of reproduction techniques in farm animals. Among these techniques, in vitro production of bovine embryos ... [more ▼]

Recent progress in gamete biology and early embryo development was responsible for great evolution of reproduction techniques in farm animals. Among these techniques, in vitro production of bovine embryos was developed from slaughterhouse ovaries. This method has been used for individual animals. However, large variations in results were observed, due to several factors, including reproductive state and age of the donor. Inspite of this limitation, in vitro production of bovine embryos may be helpful, when slaughtering of valuable cows is recommended eg for brucellosis disease. Researches are purchased in order to increase the number of oocytes obtained per "elite" cow and to improve the ability of in vitro embryos to support freezing. [less ▲]

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See detailEffects of Acute Injection of Methylprednisolone in Man on Immunological and Non-Immunological Histamine Release from Leucocytes and Its Potentiation by Interleukin-3
Louis, Renaud ULg; Bury, Thierry ULg; Corhay, Jean-Louis ULg et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (1994), 24(1), 60-5

We investigated the effects of intravenous injection of methylprednisolone (MPR) compared with placebo (saline) on ex vivo leucocytic histamine release in eight healthy volunteers. All subjects received ... [more ▼]

We investigated the effects of intravenous injection of methylprednisolone (MPR) compared with placebo (saline) on ex vivo leucocytic histamine release in eight healthy volunteers. All subjects received in a randomized and a single-blind manner the placebo and MPR, 20 mg and 125 mg, each injection given in 2 week intervals. On each occasion blood samples were taken just before and 24 h after the intravenous injection to determine circulating leucocyte counts and leucocytic histamine release induced by anti-IgE (1/2000) and FMP (Formyl-Methionyl-Phenylalanine) (10(-5) M) and its modulation by IL-3 (2 ng/ml). MPR 20 mg and 125 mg significantly increased circulating leucocyte counts (P < 0.05 and P < 0.001 respectively) but decreased leucocytic histamine content (P < 0.05 and P < 0.001 respectively) by 24 h. Placebo had no effect. As for circulating basophils, after 24 h they were decreased by 125 mg MPR (P < 0.05) but increased by 20 mg (P < 0.05). Anti-IgE-induced HR was significantly inhibited by 125 mg MPR (P < 0.05) but not by 20 mg MPR or by the placebo. In contrast, neither MPR (20 mg and 125 mg) nor placebo significantly reduced FMP-induced HR. The strong potentiation by IL-3 of HR evoked by anti-IgE and FMP at baseline (P < 0.001) persisted 24 h after injection of MPR or placebo (P < 0.001 except P < 0.05 for anti-IgE-induced HR after 125 mg MPR).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailLa tribologie, une spécialité liégeoise
Bozet, Jean-Luc ULg

in Athena (1994), 97

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See detailAnaphylatoxin C5a Production During Short-Term Submaximal Dynamic Exercise in Man
Camus, G.; Duchateau, J.; Deby, Ginette ULg et al

in International Journal of Sports Medicine (1994), 15(1), 32-5

We studied the effects of short-term submaximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and ... [more ▼]

We studied the effects of short-term submaximal exercise on the plasma levels of myeloperoxidase ([MPO]) and C5a anaphylatoxin ([C5a]), taken as specific markers of polymorphonuclear neutrophil (PMN) and complement activation, respectively. Eleven young, healthy male volunteers were subjected to a constant-load concentric exercise on a cycle ergometer (20 min at 80% maximal oxygen uptake). Mean resting MPO and C5a concentrations were 437 +/- 113 and 0.47 +/- 0.21 ng/ml, respectively. During exercise, [MPO] and [C5a] increased significantly (p < 0.001) towards respective peak values of 649 +/- 131 and 1.3 +/- 0.6 ng/ml. A rapid decrease of both [MPO] and [C5a] was observed during recovery. The similar time course of [MPO] and [C5a] changes and the highly significant relationship between these two variables (r = 0.651; p < 0.001) argues for the possible involvement of the complement anaphylatoxin C5a in the process of PMN degranulation. During exercise, the number of circulating PMN increased (+80%; p < 0.001) and remained practically unchanged up to 20 minutes of recovery. As [MPO] and PMN count were not significantly related (r = 0.2; p < 0.1), we concluded that the activation of PMN was independent of their mobilization. [less ▲]

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See detailEffects of Apomorphine on Sexual Behavior in Male Quail
Absil, Philippe ULg; Das, S.; Balthazart, Jacques ULg

in Pharmacology, Biochemistry & Behavior (1994), 47(1), 77-88

In the rat, dopamine (DA) facilitates male copulatory behavior. Indirect evidence based largely on neuroanatomical data suggest that in quail DA is also implicated in the control of male reproductive ... [more ▼]

In the rat, dopamine (DA) facilitates male copulatory behavior. Indirect evidence based largely on neuroanatomical data suggest that in quail DA is also implicated in the control of male reproductive behavior but there is no pharmacological evidence to support this conclusion. To test this idea, castrated testosterone (T)-treated male quail were injected with various doses of the dopaminergic agonist apomorphine (APO) in the range 1-10,000 micrograms/kg. The sexual behavior of birds was recorded starting 15 min after APO injection for a duration of 30 min. A dose-dependent inhibition of male reproductive behavior that lasted for the entire duration of the test was observed. In a second experiment, gonadectomized T-treated male Japanese quail were injected daily with APO (0, 10, or 1,000 micrograms/kg) during 8 days. Their sexual interactions with a partner were quantified either 24 h or 15 min after the last injection. No influence of the treatment on copulatory behavior was observed 24 h after the last injection, but a strong inhibition was present when the test was performed 15 min after. To research whether the inhibitory effects of APO were due to a preferential action on D2 presynaptic autoreceptors, male quail were pretreated with two different D2 antagonists (spiperone or pimozide; 0.5 or 2 mg/kg) before being injected with APO (100 micrograms or 1 mg/kg). Spiperone facilitated male sexual behavior but did not suppress the inhibitory effect of APO. No significant effect of pimozide was observed. These results support the notion that DA modulates male sexual activity in the Japanese quail. The specific role of the different dopaminergic receptor subtypes remains, however, to be elucidated. [less ▲]

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See detailDetection of Human Papillomaviruses in Paraffin-Embedded Biopsies of Cervical Intraepithelial Lesions: Analysis by Immunohistochemistry, in Situ Hybridization, and the Polymerase Chain Reaction
Delvenne, Philippe ULg; Fontaine, Marie-Anne; Delvenne, Catherine ULg et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (1994), 7(1), 113-119

One hundred and forty biopsies with an initial diagnosis of cervical intraepithelial lesion (CIL) were tested for the presence of human papillomavirus (HPV) by immunohistochemistry and in situ ... [more ▼]

One hundred and forty biopsies with an initial diagnosis of cervical intraepithelial lesion (CIL) were tested for the presence of human papillomavirus (HPV) by immunohistochemistry and in situ hybridization using commercial biotinylated probes (Vira-Type in situ assay; Digene Diagnostics, Silver Spring, MD) or probes labeled with digoxigenin by the random primer technique. Immunohistochemistry was more inferior to the in situ hybridization method, with a detection rate of 14% (20/140) compared to 61% (86/140) for the in situ assay with the digoxigenin-labeled probes. Biotinylated probes proved to be slightly less sensitive than digoxigenin-labeled probes, with a detection rate of 53% (74/140). Although less sensitive in our series taken as a whole, immunohistochemistry was positive in a few cases of CILs negative by in situ hybridization, so that the association of these techniques gave the highest detection rate (66%; 92/140). The CILs that remained negative with these methods (34%; 48/140) were investigated by the polymerase chain reaction (PCR) using consensus primers to determine definitively the presence of HPV in these lesions and were reviewed histologically to assess the diagnosis of CILs. The PCR method increased the detection rate of HPV in our series to 76% (107/140). The diagnosis of CILs was confirmed for all the biopsy specimens positive by PCR (15/15; 100%) and for all the HPV negative tissues with histological features of a high-grade lesions (7/7; 100%).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailMeasurement of Right Ventricular Ejection Fraction and Volume by the Thermodilution Technique in the Unsedated Calf
Amory, Hélène ULg; Mc Entee, Kathleen ULg; Linden, Annick ULg et al

in Research in Veterinary Science (1994), 56(1), 75-81

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end ... [more ▼]

This study was designed to test the applicability and the reproducibility of the thermodilution method in the measurement of right ventricular ejection fraction (EF), end-diastolic volume (EDV) and end-systolic volume (ESV) in unsedated cattle. In the 16 healthy calves studied, it was possible, using a fast response thermodilution catheter, to obtain characteristic exponential steplike washout curves, allowing the calculation of right ventricular EF, EDV and ESV. Five to 10 successive thermodilution curves were recorded within a few minutes and two to five similar sets of measurements were performed throughout the same day to test the reproducibility of the technique. The same protocol was repeated the following day. Right ventricular EF, EDV and ESV were reproducible successively, throughout a given day and on following days. The mean intraset, intraday and interdays coefficients of variation ranged from a mean of 4.0 (SD 4.1) per cent to a mean of 18.2 (SD 7.9) per cent. Values of right ventricular volumes and EF agreed with those previously reported in various animal species. Thermodilution was, therefore, shown to be a useful method for measuring with a satisfactory reproducibility, right ventricular EF, EDV and ESV in the unsedated healthy calf [less ▲]

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See detailSynthesis of barium-titanate by the sol-gel process
LEMOINE, Christine; Gilbert, Bernard ULg; MICHAUX, Bernard et al

in Journal of Non-Crystalline Solids (1994), 175(1), 1-13

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation ... [more ▼]

Homogeneous BaTiO3 gels were prepared by hydrolysis and polycondensation reactions between titanium isopropoxide and barium hydroxide in the presence of methoxyethanol, methanol and water. Gel formation mechanisms were investigated by Raman scattering spectrometry. Two drying methods are carried out: either in air with a possible formation of barium carbonate or in a vacuum furnace, sheltered from CO2. The influence of the drying method on texture is studied through nitrogen adsorption-desorption isotherm analyses. A heat treatment is deduced from thermogravimetry and differential scanning calorimetry results. The influence of the calcining temperature on the texture and the crystallization of the solids has been measured. For the first time, the transformation at 900 degrees C from the cubic to the tetragonal form of BaTiO3 has been observed by polarization microscopy. [less ▲]

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See detailSECULAR EVOLUTION OF THE VERTICAL COLUMN ABUNDANCES OF CHCLF2 (HCFC-22) IN THE EARTH'S ATMOSPHERE INFERRED FROM GROUND-BASED IR SOLAR OBSERVATIONS AT THE JUNGFRAUJOCH AND AT KITT-PEAK, AND COMPARISON WITH MODEL-CALCULATIONS
Zander, Rodolphe ULg; Mahieu, Emmanuel ULg; Demoulin, Philippe ULg et al

in Journal of Atmospheric Chemistry (1994), 18(2), 129-148

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory ... [more ▼]

Series of high-resolution infrared solar spectra recorded at the International Scientific Station of the Jungfraujoch, Switzerland, between 06/1986 and 11/1992, and at Kitt Peak National Observatory, Tucson, Arizona (U.S.A.), from 12/1980 to 04/1992, have been analyzed to provide a comprehensive ensemble of vertical column abundances of CHClF2 (HCFC-22; Freon-22) above the European and the North American continents. The columns were derived from nonlinear least-squares curve fittings between synthetic spectra and the observations containing the unresolved 2nu6 Q-branch absorption of CHClF2 at 829.05 cm-1. The changes versus time observed in these columns were modeled assuming both an exponential and a linear increase with time. The exponential rates of increase at one-sigma uncertainties were found equal to (7.0 +/- 0.35)%/yr for the Junfraujoch data and (7.0 +/- 0.23)%/yr for the Kitt Peak data. The exponential trend of 7.0%/yr found at both stations widely separated in location can be considered as representative of the global increase of the CHClF2 burden in the Earth's atmosphere during the period 1980 to 1992. When assuming two realistic vertical volume mixing ratio profiles for CHClF2 in the troposphere, one quasi constant and the other decreasing by about 13% from the ground to the tropopause, the concentrations for mid-1990 were found to lie between 97 and 111 pptv (parts per trillion by volume) at the 3.58 km altitude of the Jungfraujoch and between .97 and 103 pptv at Kitt Peak, 2.09 km above sea level. Corresponding values derived from calculations using a high vertical resolution-2D model and recently compiled HCFC-22 releases to the atmosphere, were equal to 107 and 105 pptv, respectively, in excellent agreement with the measurements. The model calculated lifetime of CHClF2 was found equal to 15.6 years. The present results are compared critically with similar data found in the literature. On average, the concentrations found here are lower by 15-20% than those derived from in situ investigations; this difference cannot be explained by the absolute uncertainty of +/- 11% assigned presently to the infrared remote measurements. [less ▲]

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See detailL’éthique et l’animal. Eléments pour un débat
Ansay, M.; Delaunois, A.; Gustin, Pascal ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailConséquences microcirculatoires et cellulaires de l'endotoxine
D'Orio, Vincenzo ULg

in Réanimation (1994), 1

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See detailChromosomal localization of the callipyge gene in sheep (Ovis aries) using bovine DNA markers
Cockett, N. E.; Jackson, S. P.; Shay, T. D. et al

in Proceedings of the National Academy of Sciences of the United States of America (1994), 91

A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal ... [more ▼]

A mutation causing muscular hypertrophy, with associated leanness and improved feed efficiency, has been recently identified in domestic sheep (Ovis aries). Preliminary results indicate that an autosomal dominant gene may be responsible for this economically advantageous trait. We have exploited the conservation in sequence and chromosomal location of DNA markers across Bovidae to map the corresponding callipyge locus to ovine chromosome 18 using a battery of bovine chromosome 21 markers. Chromosomal localization of the ovine callipyge locus is the first step toward positional cloning of the corresponding gene. [less ▲]

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See detailEffects of immunization against somatostatin on growth performances and growth hormone, insulin-like growth factor I and insulin plasma levels in young animals
Renaville, Robert ULg; Fernadez, J. J.; Sneyers, Myriam et al

in Zootecnica e Nutrizione Animale (1994), 20

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See detailCompte-rendu de Lucie Antoniol, Lire Ryle aujourd'hui. Aux sources de la philosophie analytique
Leclercq, Bruno ULg

in Revue Philosophique de Louvain (1994), 92

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See detailEstimation of effective and total erythropoiesis in myelodysplasia using serum transferrin receptor and erythropoietin concentrations, with automated reticulocyte parameters.
Bowen, D. T.; Culligan, D.; Beguin, Yves ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1994), 8(1), 151-5

The erythroid abnormality in patients with myelodysplasia (MDS) is multifactorial, with ineffective erythropoiesis and poor in vitro progenitor response to erythropoietin (EPO). Serum EPO concentration is ... [more ▼]

The erythroid abnormality in patients with myelodysplasia (MDS) is multifactorial, with ineffective erythropoiesis and poor in vitro progenitor response to erythropoietin (EPO). Serum EPO concentration is variable among patients for a given haemoglobin concentration. We studied 19 non-transfusion-dependent patients with MDS, and 13 healthy elderly control subjects in an attempt to define the factors governing variability in serum EPO and to further characterise the anaemia of MDS. Serum EPO concentration was appropriate for the degree of anaemia in 15/19 MDS patients, and was positively related to mean cell volume (MCV), mean cell haemoglobin (MCH), and percentage highly fluorescent reticulocytes (% HFR), but not to absolute or percentage reticulocyte count. Although the observed/predicted ratio for serum transferrin receptor (TfR) concentration was low in 12 of 19 MDS subjects, no relationship to haemoglobin concentration, reticulocytes or serum EPO was seen. Serum TfR was positively correlated with WBC and platelet counts. Serum TfR was higher in patients with sideroblastic anaemia than refractory anaemia. Standardized in vivo p50 was positively correlated to red cell 2,3 diphosphoglycerate concentration, although this was not the only factor influencing the oxygen dissociation curve. We conclude that effective erythroid output responsive to endogenous EPO drive in MDS is positively related to MCV, MCH and % HFR. Serum TfR may not represent effective output as precisely as % HFR, but may be proportional to total marrow erythropoietic activity. [less ▲]

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See detailVers une théorie générale du signe
Badir, Sémir ULg

in Degrés : Revue de Synthèses à Orientation Sémiologique (1994), 79-80

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See detailA comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group.
Serruys, P. W.; de Jaegere, P.; Kiemeneij, F. et al

in The New England journal of medicine (1994), 331(8), 489-95

BACKGROUND: Balloon-expandable coronary-artery stents were developed to prevent coronary restenosis after coronary angioplasty. These devices hold coronary vessels open at sites that have been dilated ... [more ▼]

BACKGROUND: Balloon-expandable coronary-artery stents were developed to prevent coronary restenosis after coronary angioplasty. These devices hold coronary vessels open at sites that have been dilated. However, it is unknown whether stenting improves long-term angiographic and clinical outcomes as compared with standard balloon angioplasty. METHODS: A total of 520 patients with stable angina and a single coronary-artery lesion were randomly assigned to either stent implantation (262 patients) or standard balloon angioplasty (258 patients). The primary clinical end points were death, the occurrence of a cerebrovascular accident, myocardial infarction, the need for coronary-artery bypass surgery, or a second percutaneous intervention involving the previously treated lesion, either at the time of the initial procedure or during the subsequent seven months. The primary angiographic end point was the minimal luminal diameter at follow-up, as determined by quantitative coronary angiography. RESULTS: After exclusions, 52 patients in the stent group (20 percent) and 76 patients in the angioplasty group (30 percent) reached a primary clinical end point (relative risk, 0.68; 95 percent confidence interval, 0.50 to 0.92; P = 0.02). The difference in clinical-event rates was explained mainly by a reduced need for a second coronary angioplasty in the stent group (relative risk, 0.58; 95 percent confidence interval, 0.40 to 0.85; P = 0.005). The mean (+/- SD) minimal luminal diameters immediately after the procedure were 2.48 +/- 0.39 mm in the stent group and 2.05 +/- 0.33 mm in the angioplasty group; at follow-up, the diameters were 1.82 +/- 0.64 mm in the stent group and 1.73 +/- 0.55 mm in the angioplasty group (P = 0.09), which correspond to rates of restenosis (diameter of stenosis, > or = 50 percent) of 22 and 32 percent, respectively (P = 0.02). Peripheral vascular complications necessitating surgery, blood transfusion, or both were more frequent after stenting than after balloon angioplasty (13.5 vs. 3.1 percent, P < 0.001). The mean hospital stay was significantly longer in the stent group than in the angioplasty group (8.5 vs. 3.1 days, P < 0.001). CONCLUSIONS: Over seven months of follow-up, the clinical and angiographic outcomes were better in patients who received a stent than in those who received standard coronary angioplasty. However, this benefit was achieved at the cost of a significantly higher risk of vascular complications at the access site and a longer hospital stay. [less ▲]

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See detailModification of immunoreactive EGF receptor after acute tubular necrosis induced by tobramycin or cisplatin
Leonard, I.; Zanen, J.; Nonclercq, D. et al

in Renal Failure (1994), 16(5), 583-608

Acute tubular necrosis induced by aminoglycoside antibiotics and various other nephrotoxins is followed by a regenerative process which leads to the restoration of damaged tubules. Several lines of ... [more ▼]

Acute tubular necrosis induced by aminoglycoside antibiotics and various other nephrotoxins is followed by a regenerative process which leads to the restoration of damaged tubules. Several lines of evidence indicate that tubular regeneration is mediated by polypeptide growth factors such as epidermal growth factor (EGF). Previous studies devoted to cisplatin nephrotoxicity have shown that this agent causes tubular cystic degeneration possibly related to an impairment of renal tissue repair. Thus, we examined on a comparative basis the time course of the regenerative response subsequent to tubular damage induced by tobramycin or cisplatin, particular attention being paid to renal EGF and its receptor. Female Sprague-Dawley rats (160-180 g body weight) were treated during 4 consecutive days with daily doses of 200 mg/kg tobramycin i.p. (BID) or 2 mg/kg cisplatin (once a day). Sham-treated rats were given 0.9% NaCl i.p. following the same protocol. Groups of experimental animals (n = 5-10) were terminated at increasing time intervals (1, 4, 7, 14, 21, 60 days) after cessation of treatment. One hour prior to sacrifice, each individual received i.p. 200 mg/kg 5-bromo-2'-deoxyuridine (BrdU) for the immunohistochemical demonstration of cell proliferation. Blood was collected at the time of sacrifice in order to assess glomerular filtration rate by measuring serum creatinine and BUN levels. Kidneys were analyzed with respect to total EGF determined by RIA in renal tissue homogenates, and soluble EGF was assayed in extracts prepared by centrifugation. Renal tissue was processed for the immunohistochemical detection of S-phase cells, of EGF, of EGF receptors, and of the intermediate filament vimentin, the latter being used as a marker of epithelium dedifferentiation. In absence of nephrotoxic alterations, EGF was immunolocalized in distal tubules, whereas EGF receptor immunostaining was seen in proximal tubules cells. Vimentin immunostaining was confined to glomeruli and blood vessels. Tobramycin and cisplatin caused acute tubular necrosis in proximal convoluted tubules and proximal straight tubules, respectively. Tissue damage was accompanied by renal dysfunction reflected by an elevation of serum creatinine and BUN levels. Tubular necrosis was followed by a proliferative response indicative of tubular regeneration. Regenerative hyperplasia was associated with a reduction of total immunoreactive EGF due to a decrease of tissue-bound proEGF. Tubules undergoing regenerative repair were characterized by a disappearance of EGF receptors and the presence of immunoreactive vimentin. In tobramycin-treated rats, renal dysfunction lasted for 4-7 days and was fully reversible, as indicated by the return of serum markers to normal values. [less ▲]

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See detailEffect of aspartate and glutamate on the oxoglutarate carrier investigated in rat heart mitochondria and inverted submitochondrial vesicles.
Hautecler, J.; Sluse-Goffart, C.-M.; Evens, A. et al

in Biochimica et Biophysica Acta-Bioenergetics (1994), 1185

Interaction of glutamate and aspartate with the oxoglutarate carrier was investigated in rat heart mitochondria or inverted submitochondrial particles. With mitochondria, glutamate and aspartate had no ... [more ▼]

Interaction of glutamate and aspartate with the oxoglutarate carrier was investigated in rat heart mitochondria or inverted submitochondrial particles. With mitochondria, glutamate and aspartate had no effect on the initial rate of oxoglutarate or malate uptake. With inverted submitochondrial vesicles, binding experiments indicated that aspartate bound to the oxoglutarate carrier on its matricial face and increased the affinity of the substrate binding site for malate but did not change the affinity for oxoglutarate. Glutamate had no effect on both substrate bindings. The dissociation constants of the binary substrate-carrier complexes on the matricial side were determined (1.28 +/- 0.15 mM for oxoglutarate and 2.22 +/- 0.26 mM for malate). These values, compared with those obtained previously on the cytosolic side of intact mitochondria, confirmed the asymmetry of the carrier in the native membrane (higher affinities on the cytosolic face). It is concluded that (1) aspartate and glutamate are not cytosolic effectors of the oxoglutarate carrier, (2) matricial aspartate is a positive effector of the binding of malate on the matricial side of the oxoglutarate carrier, and (3) such a characteristic may play a role in the regulation of the oxoglutarate carrier. Thus, it may be emphasized that (1) this observation is the first clear evidence of a well-defined 'sophisticated regulation' (allosteric) of a mitochondrial metabolite carrier, and (2) this regulation of the oxoglutarate carrier may have important consequences on the efficiency of reducing equivalent import in the matrix space by the malate-aspartate shuttle. [less ▲]

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See detailMarqueurs tumoraux
Charlier, Corinne ULg; Plomteux, Guy ULg

in Focus Diagnostica (1994), 2

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See detailBon anniversaire. Compte rendu de la Xe Table Ronde ‘Informatique et Égyptologie, Bordeaux, 1994’
Winand, Jean ULg

in Revue. Informatique et Statistique dans les Sciences Humaines (1994), 41

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See detailPlasma Beta-Endorphin Response of Thoroughbred Horses to Maximal Exercise
Art, Tatiana ULg; Franchimont, P.; Lekeux, Pierre ULg

in Veterinary Record : Journal of the British Veterinary Association (1994), 135(21), 499-502

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose ... [more ▼]

Ten horses underwent a standardised strenuous treadmill exercise test, before, during and after which measurements were made of plasma beta-endorphin and cortisol concentrations, blood lactate, glucose, haemoglobin and pH, the activities of creatine kinase, lactate dehydrogenase and aspartate amino-transferase, and heart rate, oxygen uptake and expired minute volume. The correlations between the exercise-induced response of beta-endorphin and the changes observed in the other physiological measurements were examined. There was a large variation in the beta-endorphin response of the horses to exercise. The increase in beta-endorphin was correlated significantly and inversely with the treadmill velocity at which maximal oxygen uptake was reached. It was also significantly and directly correlated with the heart rate during recovery, the increase in plasma lactate concentration and the change in blood pH, indicating that the exercise-induced increase in beta-endorphin concentration was smaller in horses with a higher aerobic capacity [less ▲]

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See detailAspergillose chez les oiseaux marins échoués sur la côte belge
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in Annales de Médecine Vétérinaire (1994), 138(4), 277-281

Pulmonary aspergillosis is a respiratory disease usually present in birds. The agent is an ubiquitous and saprophitic fungus, belonging to the Aspergillus genus, A. fumigatus being the predominant species ... [more ▼]

Pulmonary aspergillosis is a respiratory disease usually present in birds. The agent is an ubiquitous and saprophitic fungus, belonging to the Aspergillus genus, A. fumigatus being the predominant species. Debilitation and stress are favourable for the mycosis installation in captive wild birds (Zoo and rehabilitation centers). During 90-91 and 91-92 winters, 386 birds found dead at the belgian seashore were necropsied and 9 birds were carriers of specific lesions. Complementary investigations were undertaken. Most animals were oiled and had been kept for some time in rehabilitation centers. [less ▲]

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See detailTraducteurs et traductions dans l'Egypte gréco-romaine
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1994), 69(138), 313-322

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See detailL'entérotoxémie bovine en Belgique. I. Introduction et contexte bibliographique.
Manteca, C.; Daube, Georges ULg

in Annales de Médecine Vétérinaire (1994), 138

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See detailFunctional effects of a muscarinic receptor blockade during acute respiratory distress syndrome in double-muscled calves
Genicot, Bruno; Mouligneau, Frédéric; Close, Roland et al

in Veterinary Record : Journal of the British Veterinary Association (1994), 134(5), 110-113

Eighteen Belgian white and blue double-muscled calves suffering from the acute respiratory distress syndrome were studied. Fifteen of the calves inhaled ipratropium bromide (0.6 mg) four times a day for ... [more ▼]

Eighteen Belgian white and blue double-muscled calves suffering from the acute respiratory distress syndrome were studied. Fifteen of the calves inhaled ipratropium bromide (0.6 mg) four times a day for three to four days whereas the other three control calves inhaled sterile 0.9 per cent saline. All the animals were injected with ceftiofur sodium (1 mg/kg/day) for five days, the first injection being given one hour after the first inhalation of ipratropium bromide or saline. Arterial oxygen tension, alveolar arterial oxygen difference, carbon dioxide tension and arterial pH, respiratory and heart rates, oscillatory resistance and phase angle, measured by the mono-frequency forced oscillation technique, were recorded both before and one hour and 168 hours after the first inhalation. The measurement of oscillatory resistance and phase angle made it possible to resolve the impedance of the respiratory system into its real and imaginary components. The oscillatory compliance (Cosc) was determined from the imaginary component (Im). By one hour after the first inhalation of ipratropium bromide the oscillatory resistance was already significantly reduced and Im and Cosc had significantly increased, but the other parameters showed no significant improvement. However, between one hour and 168 hours after the first inhalation all the parameters reached physiological values. The control calves did not show any change. It was concluded that the pulmonary dysfunction associated with the acute respiratory distress syndrome in these calves was at least partly due to a severe bronchoconstriction. [less ▲]

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See detailLes choix stratégiques actuels dans la prévention du processus diabétogène auto-immun
Geenen, Vincent ULg; Martens, Henri ULg; Kecha, Ouafae et al

in Médecine et Hygiène (1994), 52

Le diabète insulino-dépendant (DID) est de plus en plus admis comme résultant d'une rupture de la tolérance immunitaire vis-à-vis de la cellule ß pancréatique. La compréhension des mécanismes centraux et ... [more ▼]

Le diabète insulino-dépendant (DID) est de plus en plus admis comme résultant d'une rupture de la tolérance immunitaire vis-à-vis de la cellule ß pancréatique. La compréhension des mécanismes centraux et périphériques de la tolérance vis-à-vis de la cellule ß doit logiquement aboutir à une prévention non toxique et efficace du DID. Deux choix stratégiques sont proposés à l'heure actuelle. D'une part, la tolérance périphérique à l'insuline en tant que cible du processus auto-immun pourrait être restaurée via l'administration d'insuline à faibles doses par voie sous-cutanée ou orale. D'autre part, le facteur de croissance apparenté à l'insuline de type 2 (IGF2) pourrait réinduire la tolérance centrale de l'insuline et, secondairement, de la cellule ß insulino-sécrétrice. [less ▲]

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See detailcompte rendu de : N. Giovè Marchioli, Alle origini delle abbreviature latine. Una prima ricognizione (I secolo a.C. - IV secolo d.C.)
Rochette, Bruno ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1994)

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See detailCloning And Characterization Of Mn, A Human Tumor-Associated Protein With A Domain Homologous To Carbonic-Anhydrase And A Putative Helix-Loop-Helix Dna-Binding Segment
Pastorek, J.; Pastorekova, S.; Callebaut, I. et al

in Oncogene (1994), 9(10),

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See detailA Partial Approach To Model Checking
Godefroid, Patrice; Wolper, Pierre ULg

in Information & Computation (1994), 110(2), 305--326

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See detailBI-BASED 2223 SUPERCONDUCTING POLYCRYSTALLINE MATERIALS PREPARED BY EITHER A SOLID-STATE ROUTE OR A GLASSY MATRIX PRECURSOR METHOD - CHEMICAL-ANALYSIS AS WELL AS ELECTRICAL AND THERMAL TRANSPORT-PROPERTIES
Cloots, Rudi ULg; Bougrine, Hassan ULg; HOUSSA, M. et al

in Physica C (1994), 231(3-4), 259-270

Two routes have been followed in order to prepare Bi1.7Pb0.3Sr2Ca2Cu3O(y) superconducting materials. Bi1.7Pb0.3CuO4 is always used as one of the starting basic materials. The first route involves a new ... [more ▼]

Two routes have been followed in order to prepare Bi1.7Pb0.3Sr2Ca2Cu3O(y) superconducting materials. Bi1.7Pb0.3CuO4 is always used as one of the starting basic materials. The first route involves a new experimental procedure based on the solid state synthesis of separate intermediate phases, mixed together in a two (Bi1.7Pb0.3CuO4 + 2SrCaCuO3), three (Bi1.7Pb0.3CuO4+2SrCuO2+2CaCO3) or four (Bi1.7Pb0.3CuO4+(1/12)Sr8Ca6Cu24O41 + (3/2)CaCO3 + (4/3)SrCO3) powder process. Electric resistivity versus temperature measurements are presented. Even though the T(c)(0) of each sample is above 100 K, X-ray diffraction shows that the main phase is the 2212 phase in each case. Relatively pure 2223 materials have, however, successfully been produced by the second method, which starts from a glassy intermediate phase and involves a so-called 'matrix' method. The glass precursor phase is composed of one (Bi1.7Pb0.3CuO4), two (Bi1.7Pb0.3CuO4 + 2CaCO3), and three (Bi1.7Pb0.3CuO4 + (3/2)CaCO3 + (4/3)SrCO3) components as for the solid state routes. The role of both the added alkaline earth crystalline compounds and the glass matrix precursors in this second method turns out to be very important. We propose a schematic structural model in order to explain the selectivity of the starting materials. SrCaCuO3 is found to be a good precursor of the 2212 phase, while SrCuO2 gives rise to the 2223 phase. It seems that the presence of CaCO3 in the glassy intermediate phase, thus acting as a cation reservoir, is very useful for the production of the 2223 phase. Electric resistivity, thermal conductivity and thermopower versus temperature measurements are also presented and discussed in terms of intergrowths and variations of cationic compositions in the Bi-based layers. [less ▲]

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See detailCrise de presse. Le journalisme au péril du « reportage » (France, 1870-1890)
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1994), 24(automne), 123-152

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See detailTHERMAL-CONDUCTIVITY OF PURE OR IRON-DOPED YBA2CU3O7-DELTA WITH OR WITHOUT AN EXCESS OF CUO
Houssa, M.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in Journal of Physics : Condensed Matter (1994), 6(31), 6305-6316

The thermal conductivities of YBa2(Cu1-xFex)3O7-delta + y% CuO ceramics for 0 < x < 0.03 and 0 < y < 5 have been measured. The thermal conductivities of all samples exhibit a minimum in the vicinity of ... [more ▼]

The thermal conductivities of YBa2(Cu1-xFex)3O7-delta + y% CuO ceramics for 0 < x < 0.03 and 0 < y < 5 have been measured. The thermal conductivities of all samples exhibit a minimum in the vicinity of the critical temperature T(c) and a maximum near T(c)/2. These results are interpreted with the help of an electronic model, i.e. supposing that the main contribution to the thermal conductivity below T(c) is due to electron scattering in the CuO2 planes. Within a simple two-fluid model derived from kinetic theory, taking into account the temperature dependence of the electronic relaxation time and the normal charge carrier concentration, we obtain theoretical curves which reproduce the experimental results quite well. We also take into account the porosity of the samples (in term of an intergrain contribution) to derive the electronic thermal conductivity. The parameter values of the model and the observed minimum are explained in terms of physical properties. In particular, the contribution of superconductivity fluctuations to the thermal conductivity is shown to be negligible with respect to other mechanisms. [less ▲]

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See detailDerechef Ounamon, 2,13-14
Winand, Jean ULg

in Göttinger Miszellen (1994), 139

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See detailRecension de l'ouvrage de Silvano Petrosino, "Jacques Derrida et la loi du possible"
Steinmetz, Rudy ULg

in Cahiers Internationaux de Symbolisme (1994)

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See detailAlienating Language and Darl's Narrative Consciousness in As I Lay Dying
Delville, Michel ULg

in The Southern Literary Journal (1994)

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See detailUne contrefaçon liégeoise exemplaire : les Œuvres du philosophe bienfaisant (1764)
Droixhe, Daniel ULg

in Bulletin de la Société Royale Le Vieux-Liège (1994), 265

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See detailLa rhétorique, la sémiotique et le comique
Defays, Jean-Marc ULg

in RSSI : Recherches Sémiotiques = RSSI: Semiotic Inquiry (1994), 14(3), 81-101

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See detailInteractions between the biofilm growth and the hydrodynamics in an aerobic trickling filter
Lekhlif, B.; Toye, Dominique ULg; Marchot, Pierre ULg et al

in Water Science & Technology (1994), 29

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See detailMeasurement of apolipoproteins B and A by radial immunodiffusion: methodological assessment and clinical applications.
Cano, M. D.; Gonzalvo, C.; Scheen, André ULg et al

in Annales de Biologie Clinique (1994), 52(9), 657-61

The clinical evaluation of apolipoproteins is of interest in order to characterize the risk profile for ischemic heart disease both in normolipidemic and hyperlipidemic subjects. In the non-specialized ... [more ▼]

The clinical evaluation of apolipoproteins is of interest in order to characterize the risk profile for ischemic heart disease both in normolipidemic and hyperlipidemic subjects. In the non-specialized and/or small practice clinical laboratory, the measurement of some apolipoproteins can be undertaken by simple methods of immunological analysis, among which radial immunodiffusion can be of interest due to its simplicity of use and because it does not require specific equipment. In this work several methodological questions concerning the measurement of plasma apolipoproteins B and A by radial immunodiffusion have been addressed; the results show that this method is particularly reliable for the apo B assay. Regression analysis between values obtained with radial immunodiffusion and radioimmunoassay was r = 0.972 for apo B and r = 0.782 for apo A. The recovery rate was above 90% for both apolipoproteins (93.8% for apo B and 99.5% for apo A). The inter and intraassay coefficients of variation were below 5%, and the detection limits were estimated as 9.6 mg/dl for apo A and 6.9 mg/dl for apo B. Neither the ingestion of a standard breakfast (500 Cal, 17 g fat, 120 mg cholesterol) 2 h prior to testing nor freezing the sample significantly affected the measurement of apolipoproteins B and A. Mean plasma concentrations of both apolipoproteins measured by radial immunodiffusion in normo and hyperlipidemic subjects are also presented. [less ▲]

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See detailAcute myocardial infarction in a young female migraineur: sumatriptan suspected, but found not guilty.
Schoenen, Jean ULg; Delree, P.; Moonen, Gustave ULg

in Cephalalgia : An International Journal of Headache (1994), 14(4), 305

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See detailThe use of acarbose in the prevention and treatment of hypoglycaemia.
Lefebvre, Pierre ULg; Scheen, André ULg

in European Journal of Clinical Investigation (1994), 24 Suppl 3

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In ... [more ▼]

This paper reviews the use of acarbose in the prevention and treatment of hypoglycaemia. In diet- or sulfonylurea-treated patients, acarbose may reduce the incidence of late postprandial hypoglycaemia. In insulin-treated patients, acarbose treatment usually requires reduction of the insulin dose; one study has shown that 100 mg acarbose at night significantly reduces the incidence of mid-evening and nocturnal hypoglycaemia. Several studies have suggested acarbose to be a useful adjunct to the management of reactive hypoglycaemia in the non-diabetic patients. Long-term prospective studies are still needed to document this last indication of acarbose or other alpha-glycosidase inhibitors. [less ▲]

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See detailSynthesis and pharmacology of pyrid-3-yl sulfonylureas and thioureas as astrocytic Na+ 2Cl- K+ cotransporter inhibitors
Masereel, B.; Renard, P.; Pirotte, Bernard ULg et al

in European Journal of Medicinal Chemistry (1994), 29

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See detailDetection of early sympathetic cardiovascular neuropathy by squatting test in NIDDM.
Marfella, R.; Salvatore, T.; Giugliano, D. et al

in Diabetes Care (1994), 17(2), 149-51

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three ... [more ▼]

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three groups of nonsmoking, nonobese subjects were studied: 10 healthy subjects, 10 NIDDM patients without autonomic neuropathy (AN), and 10 NIDDM patients with AN defined by the presence of a pathological deep-breathing value. All subjects were given three postural tests: lying-to-standing, sitting-to-standing, and squatting test. Heart rate (HR) and finger arterial pressure were recorded with a noninvasive technique. RESULTS--Blood pressure (BP) fall (expressed as decremental area) was not significantly different among the groups at standing up after sitting or lying. By contrast, a significantly greater BP drop occurred in NIDDM patients with AN (1,123 +/- 245 mm2) compared with NIDDM patients without AN (460 +/- 232 mm2) or normal subjects (429 +/- 138 mm2, P < 0.001). The HR increase after all the orthostatic maneuvers was smaller in diabetic patients with AN (P < 0.01) compared with that recorded in other groups. Significant correlations were observed between BP fall after squatting and either the expiration:inspiration ratio at deep breathing (r = -0.77, P < 0.001) or the duration of diabetes (r = 0.76, P < 0.001). CONCLUSIONS--The intrinsic orthostatic load of the squatting test, which is greater than conventional postural maneuvers, makes the squatting test an easy and useful test to detect early orthostatic dysregulation in NIDDM. [less ▲]

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See detailChemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-kappa B DNA binding proteins.
Qian, J.; Bours, Vincent ULg; Manischewitz, J. et al

in Journal of Immunology (1994), 152(8), 4183-91

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on ... [more ▼]

To delineate cellular genes that are required for optimal HIV-1 infection, CEM cells were subjected to treatment with the chemical mutagen ethylmethanesulfonate (EMS) and subclones were selected based on their increased resistance to HIV-1 infection and reduced syncytium formation, despite relatively normal CD4 expression (20,000 to 25,000 receptors/cell). Two subclones with this phenotype demonstrated a diminished capacity of HIV-1 long terminal repeat-chloramphenicol acetyl transferase expression either after treatment with the protein kinase C activator PMA, or through Tat-mediated transactivation. In this study, we show that the cellular levels of the NF-kappa B DNA binding proteins (but not AP1 or SP1) are markedly reduced in these cell mutants both at the mRNA and protein levels, resulting in reduced nuclear localization of p50/p65 after PMA induction or treatment with the lymphokine TNF-alpha. Transient reconstitution with a plasmid expressing p50 resulted in partial recovery of PMA-inducible LTR-chloramphenicol acetyl transferase expression. These data suggest that, at least in the CEM T cell line, a selective reduction in the NF-kappa B DNA binding proteins is sufficient to curtail HIV-1 infection. [less ▲]

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See detailBovine Growth Hormone-Taqi Rflp And Quantitative Traits Breed Selected For Growth Performances And Meat Production
Sneyers, M.; Renaville, Robert ULg; Falaki, M. et al

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1994), 102(2),

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See detailGalectins: a family of animal beta-galactoside-binding lectins.
Barondes, S. H.; Castronovo, Vincenzo ULg; Cooper, D. N. et al

in Cell (1994), 76(4), 597-8

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See detailLocalisation scintigraphique de tumeurs neuroendocrines et de leurs métastases par un analogue de la somatostatine: [111In-DTPA-d-phe1] octreotide
Beckers, Albert ULg; Pham, V. T.; Abs, R. et al

in Médecine & Chirurgie Digestives (1994), 23(3), 145-150

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See detailLate Devonian-Early Carboniferous miospores from the Menen borehole, Namur Synclinorium, Belgium
Loboziak, S.; Streel, Maurice ULg; Dusar, M. et al

in Review of Palaeobotany and Palynology (1994), 80(1/2), 55-63

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See detailEtude épidémiologique de la toxoplasmose chez les femmes enceintes à Amiens (Picardie). Nécessité d'une enquête nationale
Carme, Bernard; Lenne, Evelyne; Tirard, Véronique et al

in Médecine et Maladies Infectieuses (1994), 24

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives ... [more ▼]

L'étude avait pour but d'évaluer le niveau d'immunité vis à vis de la toxoplasmose des femmes venant d'accoucher à Amiens entre mars 1993 et avril 1994 ainsi que leur connnaissance des mesures préventives vis à vis de cette parasitose. Cette étude a permis de mettre en évidence la bonne connaissance des mesures préventives vis à vis de la toxoplasmose chez les femmes non immunes. Ceci a permis également de préciser les données épidémiologiques de la toxoplasmose à Amiens. Le choix d'un protocole incluant les femmes au moment de l'accouchement pourrait être complété par celui de femmes en début de grosesse pour éviter d'exclure les interruptions de grossesse. Cette étude devrait déboucher sur une enquête nationale qui permettrait de préciser l'épidémiolgoie de la toxoplasmose en France. [less ▲]

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See detailAnalyse de variables associées à l’action pédagogique dans un programme d’activités physiques quotidiennes au niveau élémentaire
Cloes, Marc ULg; Delfosse, Catherine; Ledent, Maryse et al

in Revue de l'Education Physique (1994), 34(2-3), 103-116

Dans notre société, où la notion d'effort physique régulier tend à disparaître, l'école devrait être investie d'une mission préventive. Elle devrait être à même de proposer aux enfants des occasions de ... [more ▼]

Dans notre société, où la notion d'effort physique régulier tend à disparaître, l'école devrait être investie d'une mission préventive. Elle devrait être à même de proposer aux enfants des occasions de pratique susceptibles de compenser les lacunes existantes. Les résultats de ces expériences soulignent fréquemment les effets favorables de l'activité quotidienne sur les aptitudes physiques et/ou motrices des enfants qui y participaient. ... [less ▲]

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See detailNONEQUILIBRIUM EFFECTS IN THE THERMAL-CONDUCTIVITY OF BI-BASED HIGH-TEMPERATURE SUPERCONDUCTORS
Bougrine, Hassan ULg; SERGEENKOV, S.; Ausloos, Marcel ULg et al

in Solid State Communications (1994), 91(7), 571-575

Thermal conductivity of two Bi-based high temperature superconducting ceramics, 2212 and 2223, with a markedly different microstructure have been examined. A pulse technique has been used. Depending on ... [more ▼]

Thermal conductivity of two Bi-based high temperature superconducting ceramics, 2212 and 2223, with a markedly different microstructure have been examined. A pulse technique has been used. Depending on the heating pulse duration, the more weak-links-containing 2223 sample shows either equilibrium or nonequilibrium behavior. The temperature dependence of the thermal conductivity between 110 K and 180 K is found to obey the Arrhenius law. The experimental observations are interpreted as a thermally activated heat flux motion through the polycrystalline grain boundaries with an energy barrier of nearly 10meV. It is likely due to a phase slip mechanism. An extra relaxation process due to the pore content/structure is thus emphasized in such regimes. [less ▲]

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See detailModifier les représentations de l'échec à l'école normale
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1994), 18-19

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See detailSurface pressure in SOS models
De Coninck, Joël; Limbourg, Sabine ULg; Newman, Charles

in Thin Solid Films (1994), 244

Microscopic models of the solid-on-solid type were considered to describe the surface pressure of monolayers and bilayers on top of another layer in two and three dimensions. The two interfaces, above and ... [more ▼]

Microscopic models of the solid-on-solid type were considered to describe the surface pressure of monolayers and bilayers on top of another layer in two and three dimensions. The two interfaces, above and below the film, were studied in simultaneous thermal equilibrium without imposing a fixed profile for the first fluid or solid. It is shown that the associated mean field approximation leads to an exact determination of the surface pressure isotherms revealing the possible existence of plateaux, typical of first-order phase transitions. [less ▲]

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See detailCauses de mortalité et teneur en métaux lourds de Guillemots de Troïl Uria aalge échoués le long du littoral belge.
Bouquegneau, Jean-Marie ULg; Debacker, Virginie ULg; Antoine, Nathalie et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 211-217

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See detailMicroencapsulation by Coacervation of Poly(lactide-co-glycolide). III. Characterization of the Final Microspheres
Nihant, Nicole; Stassen, Sophie; Grandfils, Christian ULg et al

in Polymer International (1994), 34

This paper deals with protein microencapsulation by coacervation of poly(lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of silicone oils of various viscosities. This coating technique ... [more ▼]

This paper deals with protein microencapsulation by coacervation of poly(lactide-co-glycolide) solutions in CH2Cl2 induced by the addition of silicone oils of various viscosities. This coating technique proceeds along three steps: phase separation of the coating polyester, adsorption of the coacervate droplets around the protein phase, and hardening of microparticules. Size distribution, surface morphology and internal porosity of the final microspheres clearly depend on the main characteristics of the coacervate, particularly the viscosity, in a direct connection with the CH2Cl2 content. Indeed, the whole porosity (which may be as high as 80%), average pore size and broadness of pore size distribution decrease as the coacervate is more viscous. Hardening of the coacervate droplets is thus so fast that the organic solvent is entrapped within the polymer matrix and predetermines the internal porosity. Finally, size distribution of microspheres is bimodal in a clear relation with the coacervate viscosity. A less viscous coacervate favours smaller microspheres (within the 7-90 µm range), contaminated with a minor population of microparticles below 4 µm. [less ▲]

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See detailFouilles 1994 à l'Abri du Pape et à la Grotte du Bois Laiterie (Province de Namur)
Otte, Marcel ULg; Straus, Lawrence; Lacroix, Philippe et al

in Notae praehistoricae (1994), 14

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See detailUtility of non-invasive ambulatory bood pressure monitoring in a hypertension clinic
Saint-Remy, Annie ULg; Dubois, Bernard ULg; Krzesinski, Jean-Marie ULg et al

in CVD Epidemiology newsletter (1994), 49(Spring), 50

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See detailTheoretical Conformational-Analysis And Synthesis Of Analogs Of The Heptapeptide Antibiotic K-582-A
Decoen, Jl.; Wathelet, Bernard ULg; Demeuse, F. et al

in International Journal of Peptide and Protein Research (1994), 43(1),

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See detailEtude comparative de six systèmes d'immunodosage de la ferritine sérique au cours de maladies rhumatismales
Revenant, M. C.; Vernet, M.; Rymer, J. C. et al

in Eurobiologiste (L') (1994), XXVIII(2), 35-41

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See detailGender and diagnostic performance of the growth hormone response to clonidine for major depression : A large scale multicenter study
Schittecatte, Michel; Charles, Gerard; Machowski, R. et al

in American Journal of Psychiatry (The) (1994)

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See detailTEMPERATURE-DEPENDENCE OF GROWTH, ENZYME-SECRETION AND ACTIVITY OF PSYCHROPHILIC ANTARCTIC BACTERIA
Feller, Georges ULg; Narinx, E.; Arpigny, J. L. et al

in Applied Microbiology & Biotechnology (1994), 41(4), 477-479

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of ... [more ▼]

Five psychrophilic Antarctic bacteria have been selected for their capacity to secrete exoenzymes into culture medium. These strains are able to grow from 0 to about 25 degrees C. However, production of lipase from Moraxella, alpha-amylase from Alteromonas haloplanctis, beta-lactamase from Psychrobacter immobilis and protease from Bacillus is maximal at temperatures close to that of their environment (-2 to 4 degrees C) and is strongly inhibited at higher temperatures. This thermal effect involves alterations in the secretory pathway in the upper range of temperatures, losses due to the enzyme thermal lability and in some cases to reduction in cell development. The apparent optimal activity temperature of these enzymes is between 30 and 40 degrees C, i.e. about 20 degrees C lower than that of their mesophilic counterparts. [less ▲]

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See detailLe projet d'entreprise d'insertion: son impact en termes budgétaires et d'emplois
Defourny, Jacques ULg; Lequet, Nathalie; Tilkin, Michel

in Reflets et Perspectives de la Vie Economique (1994), XXIII(1-2), 157-171

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See detailChloride and Inorganic Phosphate Modulate Binding of Oxygen to Bovine Red Blood Cells
Gustin, Pascal ULg; Detry, Benoît; Cao, M. L. et al

in Journal of Applied Physiology (Bethesda, Md. : 1985) (1994), 77(1), 202-208

The influence of Pi and Cl on the equilibrium of oxygen binding to bovine red blood cells was assessed by plotting the whole blood oxygen dissociation curve measured under standard conditions with and ... [more ▼]

The influence of Pi and Cl on the equilibrium of oxygen binding to bovine red blood cells was assessed by plotting the whole blood oxygen dissociation curve measured under standard conditions with and without added KCl and K2HPO4. Both salts shifted the oxygen dissociation curve to the right. This effect was more marked at the highest saturation levels. At a given saturation level, the anion-induced shift was linearly related to the concentration of salt added to the blood. Cl had a greater effect than Pi. The relationship between changes in Po2 at 50% hemoglobin saturation (in Torr) and concentrations of ions added (in mmol/l) was equal to 0.0515[Cl] + 0.0302[Pi] (r2 = 0.94; P < 0.001). These changes were not due to the hyperosmolality induced by salt addition, since sucrose added in place of salts was without effect on the measured parameters. The oxygen exchange fraction expressed as percentage of saturation, i.e., the difference in hemoglobin saturation when Po2 decreases from 130 to 40 Torr, was linearly correlated to added anion concentration (in mmol/l) (= 0.102[Cl] + 0.059[Pi] (r2 = 0.95; P < 0.001)). No significant interaction between the anions was observed; their effects were purely additive. This original mechanism of controlling the oxygen affinity of bovine blood may have clinical relevance: Cl and Pi could be used to increase oxygen transport efficiency in hypoxic animals [less ▲]

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See detailComparative performance study of postal services: a productive efficiency approach
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Annales d'Economie et de Statistique (1994), (33), 187-202

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It ... [more ▼]

This paper first discusses the notion of economic performance as applied to public enterprises and argues that productive efficiency is an attractive approach to performance measurement for such firms. It then presents an empirical efficiency study of postal services which is aimed at comparing productive performance indicators across countries and at testing the effect of competition and regulation on these indicators. [less ▲]

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See detailCompte rendu de L.G. Westerink, Stephanus of Athens. Commentary on Hippocrates'Aphorisms, Sections I-II, Berlin, 1985
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1994), 44

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See detailRécidive post-opératoire de la maladie de Crohn après chirurgie curatrice
Belaiche, Jacques ULg; Louis, Edouard ULg

in Médecine et Hygiène (1994), 52

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See detailEffet différentiel d'un didacticiel d'apprentissage de l'orthographe selon le mode d'utilisation de l'ordinateur
Crahay, Marcel ULg; Huberman, M.

in Education et Recherche (1994), 16(3), 300-326

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See detailFlow modeling in an underground gasifier at great depth by the Boundary-Element Method
MATHY, B.; PIRLOT, Pierre; Pirard, Jean-Paul ULg et al

in In Situ (1994), 18(4), 399-418

In order to simulate the cavity growth of an underground gasifier in thin seams at great depth, Wilks1 has developed an original model that solves the continuity equation in the horizontal plane with the ... [more ▼]

In order to simulate the cavity growth of an underground gasifier in thin seams at great depth, Wilks1 has developed an original model that solves the continuity equation in the horizontal plane with the hypothesis of radial fluid flow around the injection well. In the model presented here, the continuity equation in the horizontal plane has been taken into account, removing the limiting assumption on flow (radial direction) assumed by Wilks. The simultaneous solution of the continuity equation and the Darcy law has been carried out using the Boundary Element Method (BEM); this method is particularly suitable for solving problems where boundary conditions are of prime importance. The model enables the influences of the permeability of the medium and gasifier geometry to be demonstrated. [less ▲]

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See detailPlasma IGF-I levels as predictive criteria of growth performances in cattle
Renaville, Robert ULg; Sneyers, Myriam; Massart, Serge et al

in Growth Regulation (1994), 4(suppl 1), 115

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See detailEnzyme Immobilization in Nanoparticles produced by Inverse Microemulsion Polymerization
Daubresse, Catherine; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Journal of Colloid & Interface Science (1994), 168

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See detailA recombinant viral haemorrhagic septicaemia virus glycoprotein expressed in insect cells induces protective immunity in rainbow trout
Lecocq-Xhonneux, F.; Thiry, M.; Dheur, I. et al

in Journal of General Virology (The) (1994), 75

Viral haemorrhagic septicaemia (VHS) is a fish rhabdovirus infection of world-wide importance. Control policies have been established but the disease still causes heavy losses in fish farming. The ... [more ▼]

Viral haemorrhagic septicaemia (VHS) is a fish rhabdovirus infection of world-wide importance. Control policies have been established but the disease still causes heavy losses in fish farming. The development of a recombinant subunit vaccine was initiated to produce a safe and effective vaccine to protect fish against VHS. The VHS virus (VHSV) glycoprotein, which induces neutralizing antibodies in rainbow trout, was chosen for expression in insect cells using a baculovirus vector. The Mr of the recombinant protein estimated by SDS-PAGE was slightly lower than that of the native viral protein. The recombinant protein displayed different degrees of glycosylation and was recognized in ELISA by neutralizing antibodies. It was transported to the plasma membrane of insect cells where its ability to induce membrane fusion was preserved. The efficacy of the recombinant protein as a vaccine was compared with those of an inactivated and an attenuated vaccine. When injected intraperitoneally into rainbow trout, the baculo-virus-encoded protein was shown (i) to induce the synthesis of VHSV-neutralizing antibodies and (ii) to confer protection against virus challenge. Immunization performed by immersion failed. This is the first report of a recombinant vaccine that protects fish against VHSV. [less ▲]

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See detailLifetime Measurements for the 4p2P° and 5p2P° Levels and calculation of Transition Probabilities in Na I
Lowe, R. M.; Biémont, Emile ULg

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailGrowth-inhibiting effects of a neem-based insecticide (Margosan-O) against Spodoptera littoralis (Lepidoptera: Noctuidae
Haubruge, Eric ULg; Seck, Dogo; Hemptinne, Jean-Louis et al

in Insect Science and its application (1994), 15(4), 243-249

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See detailLa formation des agents de santé scolaire dans le cadre du programme "Je mange bien à l'école"
Vandoorne, Chantal ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1994), (3),

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See detailQuantitative Assessment of Aerial Ammonia Toxicity to the Nasal Mucosa by Use of the Nasal Lavage Method in Pigs
Urbain, B.; Gustin, Pascal ULg; Prouvost, J. F. et al

in American Journal of Veterinary Research (1994), 55(9), 1335-1340

Effects of atmospheric ammonia (NH3) on the nasal mucosa and somatic growth were investigated in pigs exposed to 4 NH3 concentrations (0; 25; 50; and 100 ppm) for 6 days in a specifically designed air ... [more ▼]

Effects of atmospheric ammonia (NH3) on the nasal mucosa and somatic growth were investigated in pigs exposed to 4 NH3 concentrations (0; 25; 50; and 100 ppm) for 6 days in a specifically designed air-pollutant exposure chamber. Nasal lavage (NAL) was applied to quantify the ammonia-induced inflammatory response by measuring the number of neutrophils and the albumin (porcine serum albumin) concentration in the NAL liquid. In control pigs, these variables remained unchanged throughout the exposure period. In all other groups, an important ammonia concentration-related increase was recorded. The equation of the linear regression line established between the mean values of the number of neutrophils (x 10(3)) per milliliter of NAL liquid (y) recorded at the end of the exposure period and the ammonia concentrations (ppm) was: y = 69.7 + 3.3 [NH3] (r = 0.979; P < 0.020). The increase in the neutrophil count was significant (P < 0.05) at concentrations as low as 25 ppm. For albumin concentration nanograms per milliliter, the corresponding equation was: y = 574 + 14.3 [NH3] (r = 0.953; P < 0.045). However, the first significant change (P < 0.05) in this variable was only obtained for the higher concentration (100 ppm). In exposed pigs, a concentration-related depression of somatic growth was observed. The equation of the regression line plotted relating the individual values of the changes in body weight gain recorded over the exposure period expressed as percentage of the initial body weight (y) and the ammonia concentration was: y = 3.507-0.203 [NH3] + 0.001 [NH3]2 (r = 0.55; P < 0.010).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1994), 37

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair ... [more ▼]

The present experiments were designed Co challenge, without the bias of anaesthesia, the previously reported statement that intratracheal administration of Pasteurella haemolvtica does not impair haemodynamics in calves. Central venous, pulmonary arterial and capillary wedge and systemic arterial pressures were measured by fluid-filled catheters in 11 calves. Cardiac output was measured by the thermodilution technique, heart rate (HR) was derived from the ECG and stroke volume (SV), pulmonary and systemic vascular resistance were calculated. The haemodynamic values were measured hourly from the first to the tenth hour alter intratracheal inoculation of P. haemolytica. Cardiovascular response was marked and typically consisted of two hypotensive hypodynamic phases. The first, which occurred by the second hour after inoculation, consisted of a transient bradycardia and a systemic vasodilation leading to profound hypotension and reduced venous return. Cardiac performance then recovered, but systemic hypotension persisted and hypoxaemia developed. The second phase occurred by the seventh hour alter inoculation and was associated with a decline in SV, an increase in HR, and pulmonary hypertension. Three different degrees of cardiovascular dysfunctions were found, differing basically in the intensity of the first phase bradycardia and second phase reduction in SV and systemic arterial pressure, suggesting that experimental pneumonia produced by intratracheal instillation of P. haemolytica in calves results in distinct cardiovascular dysfunctions depending on the animal. Ignorance of the underlying haemodynamic status therefore precludes reliable interpretation of physiological as well as pharmacological results using this model of respiratory disease [less ▲]

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See detailDNase I hypersensitive sites far upstream of the rat tryptophan oxygenase gene direct developmentally regulated transcription in livers of transgenic mice.
Kaltschmidt, Christian; Muller, Marc ULg; Brem, Gottfried et al

in Mechanisms of Development (1994), 45(3), 203-10

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream ... [more ▼]

Expression of the gene coding for tryptophan oxygenase (TO) is switched on in rat liver about two weeks after birth. We identified two clusters of DNaseI hypersensitive (HS) sites in the TO gene upstream region; one near the promoter, the other at a distant upstream location (-8.5 kb). Hypersensitivity of upstream sites was present in adult and in 7 day old rat liver, but absent in kidney. To investigate their role in transcriptional regulation, a reporter gene controlled by both HS site regions was used to generate transgenic mice. In these animals the transgene followed the cell specific and developmental regulation of the endogenous gene: inactive after birth and active in adult liver. Transgenes containing only the promoter proximal HS site were non-functional. [less ▲]

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See detailEffects of Atmospheric Ammonia on Pulmonary Hemodynamics and Vascular Permeability in Pigs: Interaction with Endotoxins
Gustin, Pascal ULg; Urbain, B.; Prouvost, J. F. et al

in Toxicology and Applied Pharmacology (1994), 125(1), 17-26

The influence of atmospheric ammonia on the somatic growth, the plasma cortisol and ammonia concentrations, and cell blood counts was investigated in pigs exposed to four concentrations (0, 25, 50, and ... [more ▼]

The influence of atmospheric ammonia on the somatic growth, the plasma cortisol and ammonia concentrations, and cell blood counts was investigated in pigs exposed to four concentrations (0, 25, 50, and 100 ppm) for 6 days in a specifically designed air-pollutants exposure chamber. The effects of this gas on pulmonary vascular hemodynamics and permeability and on the endotoxin-induced vascular response were also assessed using an isolated perfused lung preparation. The total pulmonary blood flow resistance (Rt) was partitioned into four components: arterial (Ra), pre-(Ra′) and post-(Rv′) capillary and venous (Rv). The capillary filtration coefficient (Kf,c) was evaluated by using a gravimetric technique. None of the concentrations of ammonia significantly modified the plasma cortisol and ammonia concentrations or the differential leukocyte percentages and total white blood cell count, suggesting an absence of stress related to ammonia. In exposed animals, lethargy and a concentration-related depression of the somatic growth were observed. The equation of the regression line plotted relating the mean values of the changes in body weight gain recorded over the exposure period expressed as percentages of the initial body weight (y) and ammonia concentrations (x) was: y = 3.204 − 0.177x + 0.001x2(r = 0.99; p≤0.013). Endotoxin infused in the perfusion liquid of lungs from unexposed animals for 180 min induced a significant 208% increase in Rt (p < 0.001) which can be ascribed to a 338 and 180% increase in Ra′ and Rv′, respectively. Endotoxin infusion also induced a 62% (p ≤ 0.001) increase in the Kf,c. Exposure of pigs to ammonia at any concentration did not modify the baseline values of any hemodynamic or permeability parameters. However, the hemodynamic response to endotoxins in lungs from pigs exposed to 100 ppm was significantly altered. The increase in Rt, Ra′, and Rv′ observed in unexposed pigs was completely abolished as shown by the limited changes in Rt (+34.9%). An intermediate reaction (+131.7%) was obtained in pigs exposed to 50 ppm. This inhibiting effect of ammonia was closely correlated with gas concentration by a linear regression (r = 0.99; p ≤ 0.037). The changes in the Kf,c recorded in the control group were not modified by exposure to ammonia. It was concluded that exposure of pigs to aerial ammonia concentrations from 0 to 100 ppm for 6 days has no direct effect on the pulmonary microvascular hemodynamics and permeability and induces no stress response. A marked depressive effect on the somatic growth is observed at concentrations greater than 25 ppm. Concentrations greater than 50 ppm can modulate the pulmonary vascular response to endotoxins [less ▲]

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See detailAbnormal temporal patterns of glucose tolerance in obesity: relationship to sleep-related growth hormone secretion and circadian cortisol rhythmicity.
Van Cauter, E. V.; Polonsky, K. S.; Blackman, J. D. et al

in Journal of Clinical Endocrinology and Metabolism (1994), 79(6), 1797-805

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep ... [more ▼]

To define the chronobiology of glucose tolerance and insulin secretion in obesity, nine obese men and nine lean men were studied during constant glucose infusion for 53 h, including 8 h of nocturnal sleep, 28 h of continuous wakefulness, and 8 h of daytime sleep. Blood samples were collected at 20-min intervals to assay glucose, insulin, C-peptide, cortisol, and GH. Sleep was polygraphically monitored. Abnormal temporal profiles of glucose regulation were observed during wakefulness and sleep in obese subjects. During daytime hours, the normal profile of glucose tolerance was reversed, as an improvement, rather than a deterioration, was observed from morning to late evening. This reversal of the daytime pattern appeared to be caused by a dual defect in glucose regulation during the previous night. Indeed, during early sleep, GH secretion was markedly reduced, and the nocturnal rises of glucose and insulin secretion were dampened. During late sleep, obese subjects failed to suppress insulin secretion and plasma glucose, resulting in high morning levels. Comparisons of metabolic and hormonal patterns during nocturnal and daytime sleep suggest that the failure to suppress insulin secretion in late sleep may reflect a relative insensitivity of the beta-cell to acute inhibitory effects of cortisol in addition to insulin resistance. [less ▲]

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See detailTaqI restriction fragment length polymorphism for bovine growth hormone in bovine breeds selected for milk and/or meat
Renaville, Robert ULg; Sneyers, Myriam; Falaki, Mohammed et al

in Journal of Animal Science (1994), 72(suppl 1), 316

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