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See detailPerspectives thérapeutiques en pathologies respiratoires aiguës des bovins
Lekeux, Pierre ULg

in Point Vétérinaire (1991), 23(140), 811-815

This synthesis reviews the therapeutic strategies that could become available to the practitioner in the future in order to enhance the efficacy of the treatment of respiratory conditions in cattle (5 ... [more ▼]

This synthesis reviews the therapeutic strategies that could become available to the practitioner in the future in order to enhance the efficacy of the treatment of respiratory conditions in cattle (5 photos, 43 references). [less ▲]

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See detailSynthesis of high specificity tritium labelled chloroethylcyclohexylnitrosourea and its application to the study of DNA modification
Siew, E.; Habraken, Yvette ULg; Ludlum, D.

in Journal of the radiolabelled compounds and radiopharmaceuticals (1991), XXIX

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See detailProduction and purification of biologically active recombinant tilapia (Oreochromis niloticus) prolactins
Swennen, D.; Rentier-Delrue, Françoise ULg; Auperin, B. et al

in Journal of Endocrinology (1991), 131(2), 219-27

Recombinant expression vectors carrying tilapia prolactin-I or -II (tiPRL-I or tiPRL-II) cDNA were constructed and the tiPRL-I and II proteins were produced in E. coli as inclusion bodies. These inclusion ... [more ▼]

Recombinant expression vectors carrying tilapia prolactin-I or -II (tiPRL-I or tiPRL-II) cDNA were constructed and the tiPRL-I and II proteins were produced in E. coli as inclusion bodies. These inclusion bodies were dissolved in 6 mol urea/l. Refolding of the proteins was followed by SDS-PAGE under non-reducing conditions so as to visualize the oxidized state of the molecules. Proteins tiPRL-I and tiPRL-II were purified by gel filtration and ion-exchange chromatography. The N-terminal sequence and bioactivities of both purified proteins were then analysed. Recombinant tiPRL-I and tiPRL-II induced a significant rise in plasma calcium levels as well as in mucocyte density in the abdominal skin epithelium. When tested on kidney membrane, both proteins exhibited potency in competing with 125I-labelled tiPRL-I for binding sites, but tiPRL-I seemed to be more potent than tiPRL-II in competing for these sites. The results obtained for the biological activities tested suggest that both recombinant prolactins were correctly refolded and had retained the full biological activity previously observed with the natural hormone preparations extracted from the animals. [less ▲]

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See detailFaire partie d’une association, aujourd’hui : qui sont les jeunes qui participent, au Québec, en France et en Belgique ?
Fournier, Bernard ULg

in Égalité ; revue acadienne d’analyse politique (1991), 30(automne), 39-67

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See detailPour comprendre l'univers -- A. Delsemme, J. -C. Pecker et H. Reeves
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailInduction expérimentale de la pneumonie pasteurellique chez la chèvre : étude des modifications physiopathologiques
Bakima, M.; Kaeckenbeeck, A.; Meniai, K. et al

in Annales de Médecine Vétérinaire (1991), 135

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See detailExercices in practical Astronomy using photographs: with solutions -- Mary Teresa Brück
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

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See detailThe glucocorticoid receptor.
Muller, Marc ULg; Renkawitz, R.

in Biochimica et Biophysica Acta (1991), 1088

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See detailThe Solar System -- T. Encrenaz, J. -P. Birbing et M. Blanc
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailNouvelles données sur la bande de Sambre-et-Meuse à Ombret (Huy, Belgique)
Hance, Luc ULg; Steemans, Philippe ULg; Goemaere, E et al

in Annales de la Société Géologique de Belgique (1991), 114(1), 253--264

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See detailWebb Society Deep-Sky Observer's Handbook, Volume 8, Variable Stars -- John E. Isles
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailMolecular size and symmetry of Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase. An X-ray crystallography analysis.
Marcq, S.; Diaz-Ruano, A.; Charlier, Paulette ULg et al

in Journal of Molecular Biology (1991), 220(1), 9-12

The catabolic ornithine carbamoyltransferase (EC 2.1.3.3) from Pseudomonas aeruginosa, that shows allosteric behaviour, and a mutant version of this enzyme has been crystallized in several different ... [more ▼]

The catabolic ornithine carbamoyltransferase (EC 2.1.3.3) from Pseudomonas aeruginosa, that shows allosteric behaviour, and a mutant version of this enzyme has been crystallized in several different crystal forms. All of these have been characterized by X-ray diffraction methods. A 4.5 A resolution data set has been collected on a triclinic crystal. Analysis of the data using the self-rotation function shows that 12 monomers associate to form a particle with cubic 23 point group symmetry. [less ▲]

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See detailModèles mathématiques en hydrogéologie et paramétrisation
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1991), 113(2), 217-229

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See detailLa rentabilite du triticale
Cors, François; Bodson, Bernard ULg; Falisse, André ULg

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(4), 519-535

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See detailVertical Column Abundances and Seasonal Cycle of Acetylene, C2H2, above the Jungfraujoch Station, Derived from IR Solar observations
Zander, Rodolphe ULg; Rinsland, C.P.; Ehhalt, D.H. et al

in Journal of Atmospheric Chemistry (1991), 13

Monthly mean total vertical column abundances of acetylene have been determined from series of infrared solar spectra recorded at the Jungfraujoch station, Switzerland, between June 1986 and April 1991 ... [more ▼]

Monthly mean total vertical column abundances of acetylene have been determined from series of infrared solar spectra recorded at the Jungfraujoch station, Switzerland, between June 1986 and April 1991. The data have been obtained by nonlinear least-squares fittings of the v5 band R19 transition of C2H2 at 776.0818 cm-1. The average of 22 monthly mean total vertical columns of C2H2 retrieved during that time interval of almost 5 years was found to be equal to (1.81 +- O.12) X 1OE15 molec/cm2, which corresponds to an average mixing ratio of (0.22 +- O.013) ppbv (parts per billion by volume) in a troposphere extending from the altitude of the station (3.58 km), up to 10.5 km. Despite the large variability found from year to year, a least-squares sine fit to the data reveals a seasonal variation with an amplitude of about +- 40 % of the mean; the maximum occurs during mid-winter and the minimum in the summer. The present results are compared critically with similar in-situ data found in the literature. A sinusoidal fit to ail such free troposphere measurements made in-situ between 30° N and 60° N indicates good agreement in shape and phase with the seasonal variation derived above the Jungfraujoch, but their average column abundance, 2.3 X lOE15 molec/cm2, is about 30 % higher; this difference is explained on the basis of non-upwelling meteorological conditions generally prevailing during ground-based remote solar observations. [less ▲]

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See detailCytokines et choc septique
Lamy, Maurice ULg; Damas, Pierre ULg

in Bulletin de l'Académie Royale de Médecine de Belgique (1991), 146(6-7), 270

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See detailA method to compute reactive power margins with respect to voltage collapse
Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (1991), 6

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See detailMatadine, a cytotoxic alkaloid from Strychnos gossweileri
Quetin-Leclercq, Joëlle; Coucke, P.; Delaude, Clément et al

in Phytochemistry (1991), 30(5), 1697-1700

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on ... [more ▼]

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells. [less ▲]

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See detailIntérêt de l'enfant et paiement des pensions alimentaires après divorce en Belgique
Bawin-Legros, Bernadette; Gauthier, Anne; Guillaume, Jean-François ULg

in Population : Revue Trimestrielle de l'Institut National d'Etudes Démographiques (1991), 4

This paper is a study of parental behaviour, and more particularly that of fathers, after divorce, in which findings from a national survey carried out in Belgium are used. The payment of alimony is ... [more ▼]

This paper is a study of parental behaviour, and more particularly that of fathers, after divorce, in which findings from a national survey carried out in Belgium are used. The payment of alimony is considered to be not solely a financial solution, but as an indication of a certain acceptance of parental responsibility which is rooted in the marriage and family background that existed before the couple separated. Legal practise, which generally gives care and control of the child to the mother, also results in the continuity of the traditional type of the division of labour between the parents after their marriage has broken down. This supports the moral principle of a privileged mother-child relationship, but may also lead to a deterioration in the living standards of the mothers' households. [less ▲]

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See detailStudy of production of iturin from Bacillus subtilis : a potential antifungal agent.
Jacques, Ph; Vanhentenryck, F.; Thonart, Philippe ULg

in Archives Internationales de Physiologie et de Biochimie (1991), 99(B62),

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See detailA Note On The Comparison Of Methods For Estimating The Ileal Digestibility Of Amino-Acids In Pigs
Leterme, Pascal; Pirard, L.; Thewis, André ULg

in Animal Production (1991), 52(1), 404-406

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See detailVariations saisonnières du régime alimentaire du chevreuil (Capreolus capreolus) en Haute Belgique
Degrez, Irma; Libois, Roland ULg

in Cahiers d'Ethologie (1991), 11(1), 17-30

In Belgium, information related to the deer food are quite uncommon and, as far as the roe deer is concerned, restricted to the hunting season (autumn). Our study was conducted in two areas of southern ... [more ▼]

In Belgium, information related to the deer food are quite uncommon and, as far as the roe deer is concerned, restricted to the hunting season (autumn). Our study was conducted in two areas of southern Belgium. The first, in Hotton (50°15 N, 5°27E) is a mixed oak-beech forest with a important cover of brambles. Faeces samples were collected monthly from October 1987 to September 1988. The second area, inside the Nature reserve of "Les Hautes Fagnes" (50°30N, 6°06 E; 600 m) is an old peat-bog (Eriophorum vaginatum, Molinia coerulea, Vaccinium myrtillus and V. uliginosum) surrounded by spruce plantations. Sampling took place there only in April and in June 1989. Faeces were boiled and filtered before digestion in the Scharrer- Kurschner mixture for 30 min. Then samples were sieved under water and a small amount taken and mounted on a slide for microscopic observation. More than 13,000 small vegetal pieces were identified to the species by comparison between the observed epidermal features and a reference collection of plant epidermis. Woody plants are the main food of the roe deer in both areas: in the Hautes Fagnes, heather (Calluna vulgaris) and bilberry (Vaccinium) are the main food items whereas in Hotton, brambles are the most important part the diet in each season. In Hotton, we found that the diet was much more diversified during the green season than in the winter. The winter diet comprises mainly brambles but also heather an Vaccinium myrtillus in low quantities. Spruce needles are present only at the end of the winter. In the spring, grasses were taken but their contribution to the food of the deer was never important. During the summer, the roe deer ate more tree leaves (Quercus robur and Sorbus aucuparia). In the Hautes Fagnes, grasses were important only in the spring diet and tree leaves (Sorbus) in the summer. Some tree species were very common in both study areas (beech and spruce saplings) but nearly not eaten. The roe deer can thus considered as a selective feeder preferring high quality foods (spring grasses or young leaves) to bulky one (old grasses or hard leaves). [less ▲]

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See detailSiderophores production and Enhancement by optimization of culture conditions and transposon-mutagenesis of a fluorescent Pseudomonas.
Delfosse, Ph; Jacques, Ph; Moussaif, M. et al

in Archives Internationales de Physiologie et de Biochimie (1991), 99(B55),

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See detailA Densitometric Method for the Determination of Three Clinically Important Monosaccharides in Urine
Poukens-Renwart, Pascale; Angenot, Luc ULg

in Journal of Planar Chromatography (1991), 4(January/February), 77-79

A quantitative, densitometric, thin layer chromatographic method has been developed for the determination of three clinically important monosaccharides in ureine, after desalting.The analysis of these ... [more ▼]

A quantitative, densitometric, thin layer chromatographic method has been developed for the determination of three clinically important monosaccharides in ureine, after desalting.The analysis of these monosaccharides in urine allows to observe the potential changes induced by antiinflammatories in human small intestine permeability. Xylose, 3-O-methylglucose and rhamnose were estimated quantitatively in urine; arabinose was used as internal standard. The densitometry was performed at a wavelenght of 400 nm after a visualization reaction on HPTLC plates. In all cases, coefficients of variation of the method were less than 2.7%. [less ▲]

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See detailUptake kinetic of medium constituants during batch growth of patatoe cell cultures.
Gerard, J.; Antoine, P.; Lepoivre, Philippe ULg et al

in Biotechnology Letters (1991), 13(5), 381-384

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See detailBeams and Jets in Astrophysics -- Philip A. Hughes
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailTHE MUTATION LYS234HIS YIELDS A CLASS-A BETA-LACTAMASE WITH A NOVEL PH-DEPENDENCE
BRANNIGAN, J.; Matagne, André ULg; Jacob, Françoise et al

in Biochemical Journal (1991), 278(Part 3), 673-678

The lysine-234 residue is highly conserved in beta-lactamases and in nearly all active-site-serine penicillin-recognizing enzymes. Its replacement by a histidine residue in the Streptomyces albus G class ... [more ▼]

The lysine-234 residue is highly conserved in beta-lactamases and in nearly all active-site-serine penicillin-recognizing enzymes. Its replacement by a histidine residue in the Streptomyces albus G class A beta-lactamase yielded an enzyme the pH-dependence of which was characterized by the appearance of a novel pK, which could be attributed to the newly introduced residue. At low pH, the k(cat.) value for benzylpenicillin was as high as 50 % of that of the wild-type enzyme, demonstrating that an efficient active site was maintained. Both k(cat.) and k(cat.)/K(m) dramatically decreased above pH 6 but the decrease in k(cat.)/K(m) could not be attributed to larger K(m) values. Thus a positive charge on the side chain of residue 234 appears to be more essential for transition-state stabilization than for initial recognition of the substrate ground state. [less ▲]

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See detailUne soeur aînée de la SNT: la ligue du Coin de Terre et du foyer insaisissable
Mougenot, Catherine ULg

in Cahiers de l'Urbanisme (Les) (1991), 9(Hiver), 56-68

Le mode de vie créé et véhiculé par le concept de "cité-jardin" s'est particulièrement bien imposé en Belgique. Explication sociologique et analyse des institutions constitutives de cette tendance.

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See detailPhotoionization Mass Spectrometry of Kinetic energy-selected ions. An Ion Retarding Potential Difference method applied to NO+ and O+ from N2O.
Locht, Robert ULg; Hagenow, G.; Hottmann, K. et al

in Chemical Physics (1991), 151

A new method is described to obtain photoionization efficiency curves of kinetic energy-selected fragment ions. The method is tested and discussed in the case of the dissociative photoionization yields of ... [more ▼]

A new method is described to obtain photoionization efficiency curves of kinetic energy-selected fragment ions. The method is tested and discussed in the case of the dissociative photoionization yields of NO+ and O+ from N2O. The attention is focussed on the dissociative autoionization processes in the threshold region, in the Franck-Condon region of the N2O(A2Sigma+) state and in the Franck-Condon gap between the A2Sigma+ and B2Pi states. [less ▲]

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See detailGeographic structure and potential ecological factors in Belgium
Dufrêne, Marc ULg; Legendre, P.

in Journal of Biogeography (1991), 18(3), 257-266

The available potential ecological factors have been scored in the form of presence/absence in Universal Transverse Mercator (UTM) squares in Belgium. A correspondence analysis shows a strong underlying ... [more ▼]

The available potential ecological factors have been scored in the form of presence/absence in Universal Transverse Mercator (UTM) squares in Belgium. A correspondence analysis shows a strong underlying gradient in the data set which induces an extraordinary horseshoe effect. This gradient follows closely the altitude component. Applying the k-means clustering method on UTM squares produced geographically compact groups which are largely hierarchically nested. This indicates strong regional trends in the ecological data set. As homogeneous groups may also be artefacts created by the clustering algorithms on a continuous gradient, the relevance of the borders between homogeneous areas is tested. In general, k-means borders correspond to the main breaking lines between adjacent UTM squares. They can be referred to as natural borders. -Authors [less ▲]

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See detailProduction et utilisation du colza en Belgique.
Cartrysse, C.; Cors, F.; Wathelet, Jean-Paul ULg

in GCIRC Bulletin (1991)

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See detailLung fluid balance during recovery of appropriate supply-oxygen uptake ratio with volume loading in septic shock dogs
D'Orio, Vincenzo ULg; FATEMI, M; MENDES, P et al

in American Review of Respiratory Disease (1991), 143

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See detailThree-dimensional electron microscopy of ribosomal chromatin in two higher plants: a cytochemical, immunocytochemical, and in situ hybridization approach.
Motte, Patrick ULg; Loppes, Roland ULg; Menager, M. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1991), 39(11), 1495-506

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the ... [more ▼]

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the spatial organization of plant intranucleolar DNA, since their nucleoli have been previously reconstructed in 3-D from serial ultra-thin sections. We used the osmium ammine-B complex (a specific DNA stain) on thick sections of Lowicryl-embedded root fragments. Immunocytochemical techniques using anti-DNA antibodies and rDNA/rDNA in situ hybridization were also applied on ultra-thin sections. We showed on tilted images that the OA-B stains DNA throughout the whole thickness of the section. In addition, very low quantities of cytoplasmic DNA were stained by this complex, which is now the best DNA stain used in electron microscopy. Within the nucleoli the DNA was localized in the fibrillar centers, where large clumps of dense chromatin were also visible. In the two plant species intranucleolar chromatin forms a complex network with strands partially linked to chromosomal nucleolar-organizing regions identified by in situ hybridization. This study describes for the first time the spatial arrangement of the intranucleolar chromatin in nucleoli of higher plants using high-resolution techniques. [less ▲]

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See detailVector mesons and partial restoration of chiral symmetry
Mendez Galain, Ramon; Ripka, Georges; Jaminon, Martine ULg et al

in Europhysics Letters [=EPL] (1991), 14

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See detailWirksamkeit eines oralen Beruhigungsmittels auf das Verhalten und die zootechnischen Leistungen von Mastbullen der Wei-Blauen Belgischen Rasse
Genicot, Bruno; Mouligneau, Frédéric; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1991), 38

This trial was conducted with 22 Belgian White and Blue double-muscled cattle (body weight: 241.5 +/- 6.2 kg; age: 7 months). Two similar groups were constituted: a group of bulls which were treated with ... [more ▼]

This trial was conducted with 22 Belgian White and Blue double-muscled cattle (body weight: 241.5 +/- 6.2 kg; age: 7 months). Two similar groups were constituted: a group of bulls which were treated with potassium bromide (BT; n = 11) and another one which remained untreated UT; n = 11). The treatment (736 mg potassium bromide/kg feed dry matter) was stopped 60 days before the slaughtering day. The treatment with potassium bromide induced a significantreduction in the rear engagements during the whole trial period (221 days), in direct attacks during the period A (from day 0 to day 53) and in side-on attacks during the period B from day 54 to day 167). The daily weight gains, calculated for the whole trial period, were not significantly different between the two groups. Feed utilization was lower in treated bulls. During the period C (from day 168 to day 221), the sedative potency of potassium bromide seemed to be weaker than during the periods A and B. This might be due to the habituation to potassium bromide. On the basis of these results, we can conclude that the frequency of rear engagements and, during a restricted period of fattening, the frequencies of side and directattacks are significantly reduced when potassium bromide (736 mg/kg feed dry matter) is used. The time spent for hay intake, the frequency of water intake (even if the time consumed at the drinking trough was the same) was reduced and the time during which the bulls were standing was prolonged by bromide [less ▲]

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See detailAbcès thyroïdien a streptocoque pneumoniae associé à un goitre nodulaire toxique. A propos d'un cas
Panas, N.; Zgheib, A.; Desaive, Claude ULg et al

in Semaine des Hôpitaux de Paris (La) (1991), 34

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic ... [more ▼]

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic inflammation induced by this association. [less ▲]

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See detailA Note On The Rate Of Passage Of Digesta In Pigs Ileo-Rectostomized Or Fitted With An Ileal T-Cannula
Leterme, Pascal; Pirard, L.; Thewis, André ULg et al

in Animal Production (1991), 53(2), 253-256

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See detailL'agriculture dans la Province du Luxembourg
Burny, Philippe ULg

in Annales de Gembloux (1991), 97(1), 43-67

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See detailCompte-rendu de M. Broze : La princesse de Bakhtan
Winand, Jean ULg

in Bibliotheca Orientalis (1991), 48

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See detailLa résistance aux pesticides : mécanismes et prévention
Delaunois, A.; Gustin, Pascal ULg; Ansay, M.

in Annales de Médecine Vétérinaire (1991), 135

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See detailA Monoclonal Elisa for Bovine Viral Diarrhoea Pestivirus Antigen Detection in Persistently Infected Cattle
Mignon, Bernard ULg; Dubuisson, J.; Baranowski, E. et al

in Journal of Virological Methods (1991), 35(2), 177-188

Detection of cattle persistently infected with bovine viral diarrhoea virus (BVDV) is crucial to controlling mucosal disease. A sandwich enzyme-linked immunosorbent assay (ELISA) using monoclonal ... [more ▼]

Detection of cattle persistently infected with bovine viral diarrhoea virus (BVDV) is crucial to controlling mucosal disease. A sandwich enzyme-linked immunosorbent assay (ELISA) using monoclonal antibodies raised against the 48-kDa glycoprotein and the 120/80-kDa protein was developed for detecting antigens in leucocytes of 3 persistently BVDV-infected calves. The test is simple, sensitive and rapid. Moreover the same ELISA was able to recognise Belgian field isolates of BVDV. These results show that the test can be applied in the field. [less ▲]

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See detailSpectroscopic investigation of structure in octarellin (a de novo protein designed to adopt the alpha/beta-barrel packing)
Beauregard, Marc; Goraj, Karine; Goffin, Vincent et al

in Protein Engineering (1991), 4(7), 745-9

We present here a spectroscopic structural characterization of octarellin, a recently reported de novo protein modelled on alpha/beta-barrel proteins [K. Goraj, A. Renard and J.A. Martial (1990) Protein ... [more ▼]

We present here a spectroscopic structural characterization of octarellin, a recently reported de novo protein modelled on alpha/beta-barrel proteins [K. Goraj, A. Renard and J.A. Martial (1990) Protein Engng, 3, 259-266]. Infrared and Raman spectra analyses of octarellin's secondary structure reveal the expected percentage of alpha-helices (30%) and a higher beta-sheet content (40%) than predicted from the design. When the Raman spectra obtained with octarellin and native triosephosphate isomerase (a natural alpha/beta-barrel) are compared, similar percentages of secondary structures are found. Thermal denaturation of octarellin monitored by CD confirms that its secondary structures are quite stable, whereas its native-like tertiary fold is not. Tyrosine residues, predicted to be partially hidden from solvent, are actually exposed as revealed by Raman and UV absorption spectra. We conclude that the attempted alpha/beta-barrel conformation in octarellin may be loosely packed. The criteria used to design octarellin are discussed and improvements suggested. [less ▲]

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See detailLe décor des bâtons percés
Noiret, Pierre ULg

in Préhistoire ariégeoise - Bulletin de la Société préhistorique Ariège-Pyrénées (1991), XLVI

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See detailQuantum effects in competitive decay
Remacle, Françoise ULg; Desouter, Michèle ULg; Lorquet, Jean-Claude

in Chemical Physics (1991), 153

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See detailFouilles paléolithiques en Belgique méridionale (été 1992)
Noiret, Pierre ULg; Straus, Lawrence; Otte, Marcel ULg

in Vie archéologique (1991), 37

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See detailResting behavior of Friesian bulls 5 and 12 months old in a tie stall barn
Nicks, Baudouin ULg; Dechamps, P.; Canart, B. et al

in World Review of Animal Production (1991), 26

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See detailNucleotide sequence of the bovine cyclic-AMP responsive DNA binding protein (CREB2) cDNA.
Willems, Luc ULg; Kettmann, Richard ULg; Chen, G. et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1991), 1(6),

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See detailLe triticale en alimentation animale. Les volailles.
Leterme, Pascal; Thewis, André ULg

in Revue de l’Agriculture = Landbouwtijdschrift (1991), 44(5), 945-951

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See detailAllergic cross-reaction of teicoplanin and vancomycin
Grek, V.; Andrien, F.; Collignon, J. et al

in Journal of Antimicrobial Chemotherapy (1991), 28

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See detailDes zones industrielles aux parcs scientifiques, technologiques et d'affaires. Trente ans de mutations des sites d'entreprises
Merenne-Schoumaker, Bernadette ULg

in Hommes et Terres du Nord (1991), 1991(2-3), 152-157

Thirty years of enterprise sites' mutations This article's object tries to study the enterprise sites' evolution since thirty years. With this aim in view, it confronts the sixty years sites (the ... [more ▼]

Thirty years of enterprise sites' mutations This article's object tries to study the enterprise sites' evolution since thirty years. With this aim in view, it confronts the sixty years sites (the industrial estates) and the to-day sites (the science, technological and business parks). It also analyses the impact of this evolution on the locations. The collected data show the growing importance of zonings and the weight of the enterprises' real estate. So locations of economic activities (new or transfered) are more and more influenced by the property developers' offer strategy (public and private sectors). If the first result of this evolution is to increase the spatial disparities (on regional and local levels), such an evolution also questions a certain classic literature where the demand's strategy explained the locations. [less ▲]

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See detailEffects of Strychnopentamine on Cells Cultured in Vitro
Quetin-Leclercq, J.; Gillet, Marie-Claire ULg; Angenot, Luc ULg et al

in Chemico-Biological Interactions (1991), 80(2), 203-16

This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human ... [more ▼]

This paper describes the powerful cytotoxic action exerted by strychnopentamine (SP), a dimeric indole alkaloid extracted from Strychnos usambarensis Gilg, on B16 melanoma cells and on non-cancer human fibroblasts cultured in vitro. SP strongly inhibits cell proliferation and induces cell death at a relatively low concentration (less than 1 microgram/ml) after 72 h of treatment in the two lines. Incorporation of [3H]thymidine and [3H]leucine by B16 cells significantly decreases after only 1 h of treatment at 0.5 microgram/ml. SP induces the formation of dense lamellar bodies and vacuolization in the cytoplasm, intense blebbing at the cell surface and various cytological alterations leading to cell death. [less ▲]

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See detailMR1125988,Salmenjoki, Kimmo ,On numerical methods for shape design problems
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (1991)

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See detailThe high affinity murine laminin receptor is a member of a multicopy gene family.
Fernandez, M. T.; Castronovo, Vincenzo ULg; Rao, C. N. et al

in Biochemical and Biophysical Research Communications (1991), 175(1), 84-90

The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid ... [more ▼]

The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid cells as well as in cell lines derived from cancer cells. We have analyzed three distinct cDNA clones isolated from an Okayama-Berg cDNA library of transformed mouse fibroblasts that may represent transcripts of three different laminin receptor genes. Polymorphic changes include insertion of bases at the 5' terminus, a base substitution within the coding region resulting in an amino acid change from phenylalanine to leucine, a base substitution obliterating a polyadenylation signal, as well as changes in the length of the 3' untranslated domains. The discovery of multiple transcripts of laminin receptor genes suggests that there is a strong selective pressure to maintain laminin receptor expression in murine cells. [less ▲]

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See detailDe Grady suffragant. Dialogue rimé et chanson publiés à Liège en 1762
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1991), 19/20

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See detailAnalyse du coût d'exploitation des navires sur les voies d'eau intérieures
Marchal, Jean ULg; groupe international n°11 du Comité Permanent I

in Bulletin de l’Association Internationale Permanente des Congrès de Navigation [Bulletin de l'AIPCN] (1991), (supplément au Bulletin n°74), 20

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See detailAdult respiratory distress syndrome: local or systemic disease
Deby, Ginette ULg; Lamy, Maurice ULg; Deby, C. et al

in Critical Care (1991), 4(1), 57-83

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See detailACCUMULATION OF ACYL-ENZYME IN DD-PEPTIDASE-CATALYZED REACTIONS WITH ANALOGS OF PEPTIDE-SUBSTRATES
JAMIN, M.; Adam, Maggy; Damblon, Christian ULg et al

in Biochemical Journal (1991), 280(Part 2), 499-506

Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected ... [more ▼]

Thioester substrates can be used to study the hydrolysis and transfer reactions catalysed by beta-lactamases and DD-peptidases. With the latter enzymes, accumulation of the acyl-enzyme can be detected directly. The efficiency of various amines as acceptor substrates was in excellent agreement with previous results obtained with peptide substrates of the DD-peptidases. The results indicated the presence of a specific binding site for the acceptor substrates, Although most of the results agreed well with a simple partition model, more elaborate hypotheses will be needed to account for all the data presented. [less ▲]

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See detailDermal Dendrocytes and Photochemotherapy
Pierard, Gérald ULg; Nikkels, Arjen ULg; Arrese Estrada, Jorge ULg et al

in Virchows Archiv. A : Pathological Anatomy and Histopathology (1991), 418(4), 311-314

We studied the fate of dermal dendrocytes in patients treated with psoralens and ultraviolet light by combining immunohistochemistry and computerized image analysis. Factor-XIIIa-positive dermal ... [more ▼]

We studied the fate of dermal dendrocytes in patients treated with psoralens and ultraviolet light by combining immunohistochemistry and computerized image analysis. Factor-XIIIa-positive dermal dendrocytes were found to be altered in these patients. When compared with controls, dermal dendrocytes were often increased in number and had an uneven size and tissue distribution. Their cytoplasm was occasionally fragmented. These changes were more pronounced when early photosclerosis was present. The alterations described probably reflect vascular changes, and may be responsible for immunomodulating actions and disorder of the connective tissue structure induced by ultraviolet light. [less ▲]

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See detailActions de groupes et représentations d’entiers par des formes quadratiques quaternaires
Pays, Isabelle ULg

in Bulletin de la Société Mathématique de Belgique (1991), 43

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See detailPollution of P Cygni line profiles by Fe IV and Fe V photospheric absorption in the ultraviolet spectrum of O-type stars
Nemry, F.; Surdej, Jean ULg; Hernaiz, A.

in Astronomy and Astrophysics (1991), 247

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of ... [more ▼]

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of a P Cygni line profile, it is shown that the effect of this photospheric pollution may lead to systematic errors, exceeding typically 50 percent in the determination of mass loss rates. It is also emphasized that the importance to correct the observed P Cygni line profiles for this pollution when studying the dependence of the physical parameters, terminal velocity, etc. of the stellar winds upon the various classes and types of O stars. [less ▲]

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See detailNasal salmon calcitonin in prevention of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Sarlet, N et al

in Revista Clinica Espanola (1991), 188

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See detailLe type toponymique "mouchenière"
Boutier, Marie-Guy ULg

in Nouvelle Revue d'Onomastique (1991), 17/18

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See detailArrest of MCF-7 cell migration by laminin in vitro: possible mechanisms.
Coopman, P.; Verhasselt, B.; Bracke, M. et al

in Clinical & Experimental Metastasis (1991), 9(5), 469-84

Laminin, a major basement membrane component, arrested the migration of MCF-7/AZ human breast adenocarcinoma cells that were not invasive in vitro. Migration of invasive MCF-7/6 cells was not affected by ... [more ▼]

Laminin, a major basement membrane component, arrested the migration of MCF-7/AZ human breast adenocarcinoma cells that were not invasive in vitro. Migration of invasive MCF-7/6 cells was not affected by laminin. Both cell types expressed the 67 kD laminin receptor, at both mRNA and protein level, but did not express the alpha 6 subunit of the VLA-6 integrin-type laminin receptor. The presence of YIGSR peptides (100 micrograms/ml), reported to block the interaction between laminin and its 67 kD receptor, did not change the migratory response of MCF-7/AZ or MCF-7/6 cells when meeting laminin lanes. In addition, the migration of these cell types was not affected by the presence of 17-beta-estradiol (10(-6) M) or all-trans retinoic acid (10(-6) M), which were both reported to increase the number of 67 kD receptors. We could therefore not assign an involvement of the 67 kD receptors in migration of MCF-7 cells on laminin, nor did we find evidence that conditioned medium of MCF-7/6 cells contains factors that are able to initiate migration of MCF-7/AZ cells on laminin. [less ▲]

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See detailAntibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to β-lactam antibiotics
Pirotte, Bernard ULg; Delarge, Jacques; Coyette, Jacques ULg et al

in Journal of Antibiotics (The) (1991), 44

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See detailAcyltransferase activities of the high-molecular-mass essential penicillin-binding proteins
Adam, Maggy; Damblon, Christian ULg; Jamin, Marc et al

in Biochemical Journal (1991), 279(Part 2), 601-604

The high-molecular-mass penicillin-binding proteins (HMM-PBPs), present in the cytoplasmic membranes of all eubacteria, are involved in important physiological events such as cell elongation, septation or ... [more ▼]

The high-molecular-mass penicillin-binding proteins (HMM-PBPs), present in the cytoplasmic membranes of all eubacteria, are involved in important physiological events such as cell elongation, septation or shape determination. Up to now it has, however, been very difficult or impossible to study the catalytic properties of the HMM-PBPs in vitro. With simple substrates, we could demonstrate that several of these proteins could catalyse the hydrolysis of some thioesters or the transfer of their acyl moiety on the amino group of a suitable acceptor nucleophile. Many of the acyl-donor substrates were hippuric acid or benzoyl-D-alanine derivatives, and their spectroscopic properties enabled a direct monitoring of the enzymic reaction. In their presence, the binding of radioactive penicillin to the PBPs was also inhibited. [less ▲]

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See detailLa mort en appel. Poétique de l'invocation chez Jacques Derrida
Steinmetz, Rudy ULg

in Art&Fact (1991)

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See detailModélisation des mouvements aérodynamiques générés par le chauffage en culture protégée.
Aubinet, Marc ULg; Deltour, Jules; Nijskens, J.

in Bulletin des Recherches Agronomiques de Gembloux (1991), 26(1), 39-58

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See detailSupply dependency of oxygen uptake during endotoxin insult and volume resuscitation
D'Orio, Vincenzo ULg; FATEMI, M; MENDES, M et al

in Applied Cardiopulmonary Pathophysiology [=ACP] (1991), 4

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See detailTypicality in categorization, recognition and identification : evidence from face recognition
Valentine, Tim; Ferrara, André ULg

in British Journal of Psychology (1991), 82

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See detailRelations d'implémentation et transformations autorisées d'une spécification LOTOS
Leduc, Guy ULg

in Réseaux et Informatique Répartie (1991), 1

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See detailYohimbine can induce ethanol tolerance in an in vitro preparation of rat locus coeruleus.
Verbanck, P.; Seutin, Vincent ULg; Massotte, Laurent ULg et al

in Alcoholism, Clinical & Experimental Research (1991), 15(6), 1036-9

Noradrenergic neurons have been implicated in the development of ethanol dependence and tolerance. Moreover, the development of an hyposensitivity of alpha 2 adrenoceptors has been postulated during long ... [more ▼]

Noradrenergic neurons have been implicated in the development of ethanol dependence and tolerance. Moreover, the development of an hyposensitivity of alpha 2 adrenoceptors has been postulated during long-term exposition to ethanol. In order to test the putative role of alpha 2 receptors in ethanol intoxication, we have studied the interaction between ethanol and yohimbine, an alpha 2 antagonist, on the spontaneous firing rate of rat locus coeruleus (LC) in an in vitro slice model. The spikes from single neurons were recorded by glass microelectrodes. Ethanol at 100 mM, a concentration that parallels the behavioral effects in the human and in the animals, inhibits the firing activity of some LC cells. This inhibition was quickly reversed after stopping the ethanol perfusion and was observed for each further administration. However, if yohimbine (20 microM) was simultaneously perfused, the ethanol-induced inhibition was rapidly antagonized. This effect is reversible after long time washout of yohimbine. This suggests that alpha 2 adrenoceptors could be implicated in the inhibitory effect of ethanol on LC noradrenergic neurons and perhaps in the development of tolerance. However, other hypotheses are discussed, because yohimbine can also antagonize other types of receptors. [less ▲]

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See detailDescription des restes contenus dans un échantillon concrétionné découvert au Titelberg.
Gerrienne, Philippe ULg; Fairon-Demaret, Muriel ULg; Cordy, Jean-Marie ULg

in Bulletin de la Société Préhistorique du Luxembourg (1991), 13

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See detailLe serment de Paneb et de son fils (P Salt 124, V° 1,5-8)
Winand, Jean ULg

in Bulletin de la Société Égyptologique de Genève (1991), 15

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See detailComparaison du comportement de repos de taurillons en stabulation libre sur paille et en stabulation entravée
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1991), 135

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See detailImprovement of insulin-induced glucose disposal in obese patients with NIDDM after 1-wk treatment with d-fenfluramine.
Scheen, André ULg; Paolisso, G.; Salvatore, T. et al

in Diabetes Care (1991), 14(4), 325-32

OBJECTIVE: To study the short-term effects of the serotoninergic anorectic drug d-fenfluramine on insulin-induced glucose disposal. RESEARCH DESIGN AND METHODS: A randomized double-blind placebo ... [more ▼]

OBJECTIVE: To study the short-term effects of the serotoninergic anorectic drug d-fenfluramine on insulin-induced glucose disposal. RESEARCH DESIGN AND METHODS: A randomized double-blind placebo-controlled crossover trial with 1-wk treatment periods (2 x 15 mg/day d-fenfluramine) was conducted. Twenty obese subjects, 10 with normal oral glucose tolerance and 10 with non-insulin-dependent diabetes mellitus (NIDDM), were all treated with a weight-maintaining diet. Euglycemic-hyperinsulinemic glucose clamps with measurement of glucose kinetics with D-[3-3H]glucose were performed at either two (patients without NIDDM, 0.05 and 0.10 U.kg-1.h-1) or three (patients with NIDDM, 0.05, 0.10, and 0.50 U.kg-1.h-1) insulin delivery rates. RESULTS: In the nondiabetic subjects, no significant changes in any metabolic or hormonal parameter were measured in the basal state or during the clamp despite a slight reduction in body weight (-1.2 +/- 0.5 kg, P less than 0.05). In the diabetic patients, no significant changes in body weight or basal plasma insulin levels were observed, but fasting blood glucose levels (8.0 +/- 0.8 vs. 9.4 +/- 1.1 mM, P less than 0.005) and plasma free fatty acid concentrations (1150 +/- 227 vs. 1640 +/- 184 microM, P less than 0.05) were significantly reduced after d-fenfluramine compared with placebo. During the clamp, insulin metabolic clearance rate (MCR) was similar after both placebo and d-fenfluramine; endogenous (hepatic) glucose production was similarly and almost completely suppressed, whereas glucose disposal was remarkably enhanced after d-fenfluramine (average increase of glucose MCR 35 +/- 12%, P less than 0.02). CONCLUSIONS: Whatever the mechanism(s) involved, a 1-wk treatment with d-fenfluramine induces better blood glucose control and improves insulin sensitivity in obese patients with NIDDM independent of significant weight reduction; this last effect is not present in obese subjects with normal oral glucose tolerance. [less ▲]

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See detailCutaneous and basophilic sensitivity to substance P and gastrin in non-atopic versus atopic subjects.
Louis, Renaud ULg; Radermecker, Maurice ULg

in Allergy (1991), 46(1), 30-4

We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy ... [more ▼]

We compared the cutaneous reaction to intradermal injection of substance P, gastrin and histamine in asymptomatic atopic subjects with a history of hay fever and/or asthma versus non-atopic healthy volunteers. We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti-human IgE and Con A. Intradermal injection of substance P (3-300 pM) and gastrin (3-30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Substance P 10(-4)M caused a mean basophilic histamine release of about 15% in atopic and non-atopic subjects. Gastrin was not effective in this model. Anti-IgE and Con A-induced histamine release was significantly higher in atopic than in non-atopic volunteers. [less ▲]

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See detailComparison of the resting behaviour of Friesian and belgian White-blue fattening bulls in a littered loose house and in a stanchion barn
Vandenheede, Marc ULg; Nicks, Baudouin ULg; Dechamps, P. et al

in Applied Animal Behaviour Science (1991), 30(1-2), 183

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See detailLes "Villes-santé" de l'O.M.S
Gosset, Christiane ULg

in Education Santé (1991)

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See detailLe triticale en alimentation animale. Les ruminants.
Thewis, André ULg; Leterme, Pascal

in Revue de l’Agriculture = Landbouwtijdschrift (1991), 44(4), 707-716

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See detailThe cytokines: a possible role in sepsis
Damas, Pierre ULg

in Current Opinion in Anaesthesiology (1991), 4(2), 241-246

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See detailRevision of the Structure of Strychnochromine
Quetin-Leclercq, Joëlle; Angenot, Luc ULg; Dupont, Léon et al

in Tetrahedron Letters (1991), 32(34), 4295-4298

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to ... [more ▼]

The structure of strychnochromine, an unusual alkaloid isolated from a new batch of the root bark of Strychnos gossweileri has been revised . To confirm the indoline structure ( proposed in 1988) and to establish the stereochemistry of the compound extensive 2D-NMR experiments were carried out. The COSY experiments mostly confirmed the previous observations but the COLOC maps did not fit the first proposed structure!The problem was solved by single-crystal X-ray analysis of the p-bromobenzoyl ester of strychnochromine. The new structure, with its tetrahydroquinoline ring, is very unusual in Strychnos species but the formation of quinolines from indole alkaloids has already mentioned in some other plants ( Cinchona, Alstonia, Hunteria..). [less ▲]

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See detailChampion (Emptinne, Nr), Villa romaine (signalement archéologique)
Longrée, Dominique ULg; Breyer, Catherine; De Poorter, Alexandra

in Vie archéologique (1991), 36

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See detailDigestibilite ileale des acides amines de regimes monocereale-tourteau de soja chez le porc.
Leterme, Pascal; Thewis, André ULg; Thielemans, Marie France et al

in Revue de l’Agriculture = Landbouwtijdschrift (1991), 44(3), 423-432

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See detailBiostatistical studies on western European Dactylorhiza (Orchidaceae)-the D. maculata group
Dufrêne, Marc ULg; Gathoye, J.-L.; Tyteca, D.

in Plant Systematics & Evolution (1991), 175(1-2), 55-72

Multivariate analysis tools are exploited on a data set composed of quantitative characteristics collected on 35 populations of plants of the Dactylorhiza maculata (L.)Soó group from Western-Europe. These ... [more ▼]

Multivariate analysis tools are exploited on a data set composed of quantitative characteristics collected on 35 populations of plants of the Dactylorhiza maculata (L.)Soó group from Western-Europe. These samples lead to four well-defined clusters; this, together with qualitative, cytological and ecological arguments, allows for the recognition of four specific entities:D. maculata s.str., D. fuchsii (Druce)Soó, D. saccifera (Brongn.)Soó and D. caramulensis (Vermeulen)Tyteca. It is concluded that the floral characters play an essential role in the taxonomical distinction. It also appears that the set of characters measured, as well as the methods exploited, are especially well-suited and valuable tools for the morphological study of the genus Dactylorhiza. © 1991 Springer-Verlag. [less ▲]

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See detailStructures du cyclohexyl-1[(cycloheptylamino-4 pyridyl-3)sulfonyl]-3 urée et de l'hydrogénonitrate du cyclohexyl-1[(cyclooctylamino-4 pyridyl-3)sulfonyl]-3 urée
Dupont, L.; Dideberg, O.; Masereel, B. et al

in Acta Crystallographica (1991), C47

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See detailEros et Thanatos
Duchesne, Jean-Patrick ULg

in Art&fact (1991), 10

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See detailPhagocytose immune et non immune
Malaise, Michel ULg

in Revue Médicale de Liège (1991), 46(9), 486-503

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See detailTAXONOMIC STUDY OF MARINE OSCILLATORIACEAN STRAINS (CYANOPHYCEAE, CYANOBACTERIA) WITH NARROW TRICHOMES .1. MORPHOLOGICAL VARIABILITY AND AUTECOLOGICAL FEATURES
Wilmotte, Annick ULg

in Archiv für Hydrobiologie (1991), 92

Twenty marine and one freshwater strain, belonging to the genera Oscillatoria, Phormidium, Plectonema and Spirulina (sensu GEITLER), exhibiting a cell width less than 3-mu-m were cultivated in different ... [more ▼]

Twenty marine and one freshwater strain, belonging to the genera Oscillatoria, Phormidium, Plectonema and Spirulina (sensu GEITLER), exhibiting a cell width less than 3-mu-m were cultivated in different light intensities, temperatures and salinities. The study of the morphological variability allows one to determine the stable and variable morphological characters. The tolerances to the culture conditions, the possibility of survival in unfavourable conditions and the capacity of chromatic adaptation were investigated. The autecological characters are discussed in relation to the original habitat as well as to the taxonomic grouping of the strains based on the morphology. [less ▲]

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See detailtracheal agenesis: an unusual cause of neonatal respiratory distress
Battisti, Oreste ULg

in Pediatric Pulmonology (1991), 150

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See detailHydrolysate preparation and comparative amino acid determination by cation-exchange and gas-liquid chromatography in diet ingredients
De Schrijver, Ronny; Van Eenaeme, Christian ULg; Fremaut, D. et al

in Cerevisia and Biotechnology (1991), 16(4)

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See detailNeuroendocrine-Immunology: from systemic interactions to the immune tolerance of self neuroendocrine functions
Geenen, Vincent ULg; Robert, Françoise; Legros, Jean-Jacques ULg et al

in Acta Clinica Belgica (1991), 46

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through ... [more ▼]

In recent years, it appeared more and more that the three major integrating and adaptive systems of intercellular communication, nervous, endocrine, and immune systems, are closely interconnected. Through these interactions, psychological and neurological influences can modulate the immune response (neuroimmunomodulation), while immune cells may communicate to the neuroendocrine system by a regulatory feedback loop. On the basis of our own observations, it has been shown that the neuroendocrine-immune dialogue occurs in the thymus during the early steps of T-cell differentiation, and could be involved both in T-cell positive as well as negative selections. [less ▲]

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