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See detailCurrent issues : varicella
Stouvenakers, Nadine ULg; Sadzot-Delvaux, Catherine ULg; Rentier, Bernard ULg

in Vaccines : Children and Practice (2001), 4

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See detailDernier hoquet à Francorchamps
Abu Dalu, Firass ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailDatabase "SIGMA Pro" information system and bibliographical management of active substances of plant protection products and biocides.
Rung, J.; Tricot, B.; Copin, A. et al

in Toegepaste Biologische Wetenschappen) (2001), 66(2b),

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See detailEuthanasia: a law in Belgium?
Damas, François ULg; Damas, Pierre ULg; Lamy, Maurice ULg

in Intensive Care Medicine (2001), 27(10), 1683

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See detailMigraine - advances in genetic research and possible link to neurophysiological abnormalities
Sandor, Peter S.; Agosti, Reto; Schoenen, Jean ULg

in Schweizer Archiv für Neurologie, Neurochirurgie und Psychiatrie = Archives Suisses de Neurologie, Neurochirurgie et de Psychiatrie (2001), 152

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See detailLes bioindustries fertilisent la valorisation
Thonart, Philippe ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 131-134

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See detailLes notions d'indices et de charges en procédure pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailEquine pulmonary and systemic haemodynamic responses to endothelin-1 and a selective ETA receptor antagonist
Benamou, A. E.; Marlin, D. J.; Lekeux, Pierre ULg

in Equine Veterinary Journal (2001), 33(4), 337-44

Based on previous in vitro studies, we hypothesised that endothelin (ET) would induce vasoconstriction in the pulmonary circululation of the horse and that this action would be mediated via ET(A ... [more ▼]

Based on previous in vitro studies, we hypothesised that endothelin (ET) would induce vasoconstriction in the pulmonary circululation of the horse and that this action would be mediated via ET(A) receptors. Pulmonary and systemic haemodynamic responses to endothelin-1 (ET-1), a potent vasoactive endogenous peptide, were investigated in 6 conscious, nonsedated horses at rest. Bolus i.v. injections of exogenous ET-1 (0.1, 0.2 and 0.4 microg/kg bwt) caused significant increases in pulmonary (PAP) and carotid (CAP) artery pressures, with peak increases of 79% and 51% for mean PAP and CAP, respectively. The effect of ET-1 on PAP and CAP was rapid and transient for PAP (-10 min) but prolonged for CAP (up to 60 min). ET-1 significantly decreased cardiac output by up to 35% and significantly increased systemic vascular resistance (SVR) by up to 104%. Pulmonary vascular resistance (PVR) showed a trend (P>0.05) to increase with 0.2 and 0.4 microg/kg bwt ET-1. Infusion of a selective ET(A) receptor antagonist (TBC11251) completely inhibited the responses to a subsequent bolus of 0.2 microg/kg bwt ET-1. We conclude that exogenous ET-1 exerts a potent vasoconstrictive action on the pulmonary and systemic circulations of the horse. These effects appear to be mediated largely through ET(A) receptors in both circulations. Endothelin may play a role in hypertensive conditions in the horse. [less ▲]

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See detailBinding and multiple instantiation in a distributed network of spiking nodes
Sougné, Jacques ULg

in Connection Science (2001), 13(2), 99-126

An implementation of a distributed connectionist network of spiking neuron-like elements is presented. Spiking nodes fire at a precise moment and transmit their activation, with particular strenghts and ... [more ▼]

An implementation of a distributed connectionist network of spiking neuron-like elements is presented. Spiking nodes fire at a precise moment and transmit their activation, with particular strenghts and delays, to nodes connected to them. Wen the potential of the node reaches a particular threshold, it emits a spike. Thereafter, the potential is reset to a resting value. The receiving nodes accumulate potential, but also, slowly lose their potential through decay. As with real neurons, after firing there is a short refractory period during which the node will be completely insensitive to incoming signals, after which its sensitivity will slowly increase. Precise timing properties are used to represent symbols in a distributed manner and also to solve the problems of variable binding and multiple instantiation. Several predictions about human short-term memory, predicate processing, complex reasoning and multiple instantiation arise from this model. This network shows how symbolic processing can be achieved using neurobiologically and psychologically plausible mechanisms that also have the advantages of generalization and noise tolerance found in connectionist networks. [less ▲]

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See detailExperimental And Conformational Analyses Of Interactions Between Butenafine And Lipids
Mingeot-Leclercq, Mp.; Gallet, X.; Flore, Christelle ULg et al

in Antimicrobial Agents and Chemotherapy (2001), 45(12), 3347-54

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphtalenemethylamine hydrochloride) is an antifungal agent of the benzylamine class that has excellent therapeutic efficacy and a remarkably long duration of ... [more ▼]

Butenafine (N-4-tert-butylbenzyl-N-methyl-1-naphtalenemethylamine hydrochloride) is an antifungal agent of the benzylamine class that has excellent therapeutic efficacy and a remarkably long duration of action when applied topically to treat various mycoses. Given the lipophilic nature of the molecule, efficacy may be related to an interaction with cell membrane phospholipids and permeabilization of the fungal cell wall. Similarly, high lipophilicity could account for the long duration of action, since fixation to lipids in cutaneous tissues might allow them to act as local depots for slow release of the drug. We have therefore used computer-assisted conformational analysis to investigate the interaction of butenafine with lipids and extended these observations with experimental studies in vitro using liposomes. Conformational analysis of mixed monolayers of phospholipids with the neutral and protonated forms of butenafine highlighted a possible interaction with both the hydrophilic and hydrophobic domains of membrane phospholipids. Studies using liposomes demonstrated that butenafine increases membrane fluidity [assessed by fluorescence polarization of 1-(4-trimethylammonium-phenyl)-6-phenyl-1,3,5-hexatriene and 1,6-diphenylhexatriene] and membrane permeability (studied by release of calcein from liposomes). The results show, therefore, that butenafine readily interacts with lipids and is incorporated into membrane phospholipids. These findings may help explain the excellent antifungal efficacy and long duration of action of this drug when it is used as a topical antifungal agent in humans. [less ▲]

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See detailImmunisation against East Coast fever by the infection and treatment method: evaluation of the use of ice baths for field delivery and appraisal of an acid formulation of long-acting tetracycline.
Marcotty, T.; Billiouw, M.; Chaka, G. et al

in Veterinary Parasitology (2001), 99(3), 175-87

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern ... [more ▼]

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern Province of Zambia. The maintenance of the cold chain in liquid nitrogen up to the time of inoculation and the cost of the reference long-acting oxytetracycline (Terramycin LA, Pfizer) are the main drawbacks of the method. The work presented in this paper aims at reducing the cost of immunisation against ECF by using an ice bath for the field delivery and a cheaper long-acting oxytetracycline formulation as chemotherapeutic agent. In experimental conditions, the results from 40 calves immunised after various periods of storage on ice ranging from 4 to 32 h indicate that deferred immunisation performed with a stabilate kept on ice for up to 6h after thawing has an efficiency of 90%. Moreover, sporozoites kept on ice were still surviving 32 h after thawing. In a field trial, 91 calves were inoculated with a stabilate kept for 3.5-5.5 h after thawing and dilution whereas 86 calves were immunised using the standard method. Clinical and parasitological reactions to immunisation were monitored as well as the seroconversion. In the field trial, the deferred immunisation was more efficient than the standard method. The acid formulation of oxytetracycline that was tested was found as suitable as the reference alkaline formulation for the chemotherapeutic control of the Katete strain in ECF immunisation. One indoor trial was carried out on 10 animals and a field trial involved 93 calves. [less ▲]

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See detailGap Filling Strategies For Defensible Annual Sums Of Net Ecosystem Exchange
Falge, E.; Baldocchi, D.; Olson, R. et al

in Agricultural and Forest Meteorology (2001), 107(1),

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See detailInsecticide resistance gene transmission by insecticide-susceptible insects
Arnaud, Ludovic; Callaghan, Amanda; Haubruge, Eric ULg

in Functional Ecology (2001)

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See detailApplication and processing of geophysical images for mapping faults
Demanet, Donat; Renardy, François; Pirard, Eric ULg et al

in Computers & Geosciences (2001), 29(7), 1031-1037

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See detailHpa Axis Dysfunction in Major Depression: Relationship to 5-Ht(1a) Receptor Activity
Pitchot, William ULg; Herrera, C.; Ansseau, Marc ULg

in Neuropsychobiology (2001), 44(2), 74-7

Major depression is associated with a dysfunction of the serotonergic activity and the hypothalamic-pituitary-adrenal (HPA) axis. Moreover, a reciprocal relationship between the serotonergic and HPA axis ... [more ▼]

Major depression is associated with a dysfunction of the serotonergic activity and the hypothalamic-pituitary-adrenal (HPA) axis. Moreover, a reciprocal relationship between the serotonergic and HPA axis systems has been hypothesized. The purpose of the present study was to assess the relationship between sensitivity of 5-HT(1A) receptors as measured by hormonal (ACTH, cortisol and PRL) and temperature responses to flesinoxan and HPA axis activity as measured by the dexamethasone suppression test. The sample included 21 inpatients with major depression. Dexamethasone nonsuppressors exhibited lower ACTH responses to flesinoxan as compared with dexamethasone suppressors. The results showed that a dysfunction in 5-HT(1A) receptor activity could be due to a hypersecretion of cortisol. [less ▲]

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See detailMorphological and ecological complexity in early eukaryotic ecosystems
Javaux, Emmanuelle ULg; Knoll, A. H.; Walter, M. R.

in Nature (2001), 412(6842), 66-69

Molecular phylogeny and biogeochemistry indicate that eukaryotes differentiated early in Earth history. Sequence comparisons of small-subunit ribosomal RNA genes suggest a deep evolutionary divergence of ... [more ▼]

Molecular phylogeny and biogeochemistry indicate that eukaryotes differentiated early in Earth history. Sequence comparisons of small-subunit ribosomal RNA genes suggest a deep evolutionary divergence of Eukarya and Archaea(1); C-27-C-29 steranes (derived from sterols synthesized by eukaryotes) and strong depletion of C-13 (a biogeochemical signature of methanogenic Archaea) in 2,700 Myr old kerogens independently place a minimum age on this split(2,3). Steranes, large spheroidal microfossils, and rare macrofossils of possible eukaryotic origin occur in Palaeoproterozoic rocks(4-6). Until now, however, evidence for morphological and taxonomic diversification within the domain has generally been restricted to very late Mesoproterozoic and Neoproterozoic successions(7). Here we show that the cytoskeletal and ecological prerequisites for eukaryotic diversification were already established in eukaryotic microorganisms fossilized nearly 1,500 Myr ago in shales of the early Mesoproterozoic Roper Group in northern Australia. [less ▲]

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See detailQuoi de neuf en littératie ? : Regard sur trente ans d'évaluation de la lecture
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 71-95

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See detailThe Cloninger's biosocial model of personality
Hansenne, Michel ULg

in Année Psychologique (L') (2001), 101(1), 155-181

In this review, the author proposes a synthesis of the biosocial model of personality developed by Cloninger. This model is based on several neurobiological and clinical hypotheses. According to this ... [more ▼]

In this review, the author proposes a synthesis of the biosocial model of personality developed by Cloninger. This model is based on several neurobiological and clinical hypotheses. According to this model, the personality is described by 4 temperaments (novelty seeking, harm avoidance, reward dependence, and persistence) which are independently heritable and related to specific central neurotransmitters, and 3 characters (self-directedness, cooperativeness, and self-transcendence) that mature in adulthood. TCI (Temperament and Character Inventory) is a 226-item self questionnaire developed by Cloninger to assess the 7 dimensions of personality. The relationships between temperaments and neurotransmitters is particularly relevant in research and in clinical practice. From a clinical point of view, the model provides a foundation for integrating diagnosis and treatment planning, including both psychotherapy and pharmacotherapy. This review discuss the advantages and the limitations of this model and proposes some future directions. [less ▲]

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See detailLiquid distribution images on structured packing by X-ray computed tomography
Marchot, Pierre ULg; Toye, Dominique ULg; Pelsser, A. M. et al

in AIChE Journal (2001), 47(6), 1471-1476

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See detailDe PCB/dioxine vergiftiging in België (1999): analyse van de gezondheidsrisico’s
Bernard, A.; Broekaert, F.; De Poorter, G. et al

in Vlaams Diergeneeskundig Tijdschrift (2001), 70

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See detailHuman Fdc Express Prpc in Vivo and in Vitro
Thielen, Caroline ULg; Antoine, Nadine ULg; Mélot, France ULg et al

in Developmental Immunology (2001), 8(3-4), 259-66

Prion diseases are fatal neurodegenerative disorders caused by accumulation of abnormal prion protein (protease-resistant prion, PrPres). PrPres accumulation is also detected in lymphoid organs after ... [more ▼]

Prion diseases are fatal neurodegenerative disorders caused by accumulation of abnormal prion protein (protease-resistant prion, PrPres). PrPres accumulation is also detected in lymphoid organs after peripheral infection. Several studies suggest that follicular dendritic cells (FDC) could be the site of PrPres retention and amplification. Here we show that human follicular dendritic cells can express normal cellular prion protein (PrPc) both in situ and in vitro. When tonsillar cryosections were treated with anti-PrP antibody, the label was found on some very delicate cell extensions inside the lymphoid follicles, especially in the germinal centres. These extensions react with DRC1 antibody, used frequently to label FDC. Other structures labelled with anti-PrP antibody were the keratinocytes. To confirm the ability of FDC to synthesise PrPc, we isolated FDC by a non-enzymatic procedure and cultured them. By cytochemistry and flow cytometry it was clearly shown that FDC do produce PrPc. [less ▲]

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See detailDuck plague: a permanent threat for domestic and wild anatids
Marlier, Didier ULg; Jaumin, F.; Delleur, V. et al

in Annales de Médecine Vétérinaire (2001), 145(5, NOV-DEC), 287-291

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current ... [more ▼]

Duck plague: a permanent threat for domestic and wild anatids. Duck plague, also named duck virus enteritis is a disease of ducks, geese and swans of all ages. The authors present a review of the current knowledge about this viral infection. [less ▲]

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See detailShort-term variations of the partial pressure of CO2 in surface waters of the Galician upwelling system
Borges, Alberto ULg; Frankignoulle, Michel

in Progress in Oceanography (2001), 50(2-4), 283-302

The partial pressure of CO2 (pCO2) and dissolved oxygen saturation level (%O2) were monitored continuously during a cruise in August 1998, which sampled surface waters off the Galician coast. Data are ... [more ▼]

The partial pressure of CO2 (pCO2) and dissolved oxygen saturation level (%O2) were monitored continuously during a cruise in August 1998, which sampled surface waters off the Galician coast. Data are presented from two Lagrangian experiments carried out in an upwelling on the continental shelf and in the core of an offshore filament. The data show that daily variations in surface pCO2 and oxygen (%O2) were controlled by the diurnal cycle of primary production/respiration, temperature variations and air–sea exchange. Data obtained during various cross-shelf and cross-filament transects are also discussed and give an insight into the processes controlling large scale variations of pCO2 and %O2 in the Galician upwelling system. These data suggest that upwelling filaments are an important feature of the inorganic carbon cycle of upwelling systems. However more field data in the various eastern boundary current systems worldwide are needed. [less ▲]

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See detailLe cas clinique du mois. Syndrome d'hypertension porto-pulmonaire associe a une hypoxemie severe.
Kolan, C.; Ghuysen, Alexandre ULg; Lambermont, Bernard ULg et al

in Revue Médicale de Liège (2001), 56(8), 543-7

We report the case of a patient with liver cirrhosis who was admitted to the emergency room for rapid occurrence of dyspnea and severe hypoxemia at rest. Lung CT-scan and echocardiography did not disclose ... [more ▼]

We report the case of a patient with liver cirrhosis who was admitted to the emergency room for rapid occurrence of dyspnea and severe hypoxemia at rest. Lung CT-scan and echocardiography did not disclose any right-to-left shunt and right-sided heart catheterization evidenced major precapillary pulmonary hypertension. The present feature supports the hypothesis that the pulmonary complications of cirrhosis, the hepatopulmonary syndrome and the portopulmonary hypertension, which are usually considered as mutually exclusive, may coexist. In such circumstances, the right failing heart is the major determinant to the immediate prognosis. [less ▲]

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See detailGérer l'hétérogénéité des élèves : Méthodes de regroupement des élèves dans l'enseignement obligatoire
Monseur, Christian ULg; Demeuse, Marc ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), (7-8), 25-52

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See detailPalladium-silver sol-gel catalysts for selective hydrodechlorination of 1,2-dichloroethane into ethylene III. Kinetics and reaction mechanism
Heinrichs, Benoît ULg; Schoebrechts, Jean-Paul; Pirard, Jean-Paul ULg

in Journal of Catalysis (2001), 200(2), 309-320

The kinetics of selective hydrodechlorination of 1,2-dichloro-ethane into ethylene over a Pd-Ag/SiO2 catalyst is studied. Kinetic data at 573, 596, and 647 K have been obtained by means of experimental ... [more ▼]

The kinetics of selective hydrodechlorination of 1,2-dichloro-ethane into ethylene over a Pd-Ag/SiO2 catalyst is studied. Kinetic data at 573, 596, and 647 K have been obtained by means of experimental designs in the space of the partial pressures of the four components influencing kinetics, that is, 1,2-dichloroethane, hydrogen, ethylene, and hydrogen chloride. One model among the numerous ones examined allows us to represent correctly the experimental data. Ii: corresponds to the following mechanism: dechlorination of 1,2-dichloroethane into ethylene occurs on silver through dissociative adsorption with successive breaking of the two C-Cl bonds and desorption of C2H4. Thanks to its activation power of hydrogen by dissociative chemisorption, palladium present at the surface of the alloy supplies hydrogen atoms for regeneration of the chlorinated silver surface into metallic silver. The presence of hydrogen adsorbed on Pd also causes the undesired ethylene hydrogenation leading to a loss of olefin selectivity. (C) 2001 Academic Press. [less ▲]

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See detailPrediction Of Membrane Protein Orientation In Lipid Bilayers: A Theoretical Approach
Basyn, F.; Charloteaux, Benoît ULg; Thomas, Annick ULg et al

in Journal of Molecular Graphics & Modelling (2001), 20(3), 235-44

Over the past few years, several three-dimensional (3-D) structures of membrane proteins have been described with increasing accuracy, but their relationship with membranes are still not well understood ... [more ▼]

Over the past few years, several three-dimensional (3-D) structures of membrane proteins have been described with increasing accuracy, but their relationship with membranes are still not well understood. Recently, we have developed an empirical method, Integral Membrane Protein and Lipid Association (IMPALA), to predict the insertion of molecules (lipids, drugs) into lipid bilayers (Proteins 30 (1998) 357). The IMPALA uses a Monte Carlo minimisation procedure to calculate the depth and the angle of insertion of membrane-interacting molecules taking into account the restraints dictated by a lipid bilayer. In this paper, we use IMPALA to test the insertion of 23 integral membranous proteins (IMPs) and 2 soluble proteins into membranes. Four IMP are studied in detail: OmpA, maltoporin, MsCl channel and bacteriorhodopsin. The 3-D structures of the proteins are kept constant and the insertion into membrane is monitored by minimising the value of the restraint representing the sum of two terms, one for lipid perturbation and the other for hydrophobicity. The two soluble proteins are rejected from the membrane whereas, under the same conditions, all the membrane proteins remain inside, if the solvent accessible surface of the amino acids located inside the pore of porins is ignored. The results give the tilt angle of the IMP helices or strands with respect to the membrane surface and the depth of the protein mass centre insertion. We conclude that the restraint terms of IMPALA could be used to study the insertion of model structures or complexes of proteins within membranes. [less ▲]

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See detailJuxtafacet Cyst of the Lumbar Spine. Clinical, Radiological and Therapeutic Aspects in 28 Cases
Salmon, B.; Martin, Didier ULg; Lenelle, Jacques ULg et al

in Acta Neurochirurgica (2001), 143(2), 129-34

OBJECT: A consecutive series of 28 "operated" juxtafacet cysts is reported. We emphasize the clinical and radiological aspects leading to diagnosis. We also discuss the results of the surgical treatment ... [more ▼]

OBJECT: A consecutive series of 28 "operated" juxtafacet cysts is reported. We emphasize the clinical and radiological aspects leading to diagnosis. We also discuss the results of the surgical treatment. MATERIAL AND METHODS: Medical information and radiological studies involving 28 patients were analyzed. Each patient has been operated on by decompressive laminectomy and resection of the cyst. The diagnosis was always confirmed by a pathological examination. The cyst most frequently occurred at the L4-L5 level (n = 18), and seldom at the L5-S1 (n - 6) or L3-L4 (n - 4) levels. RESULTS: The differential diagnosis from other pathological causes responsible for a radicular compression could not be done by physical examination. Spine X-rays or myelogram were nonspecific. Computed Tomography or CT-myelography could help in the diagnosis but MR imaging was the most sensitive. In our series, the respective sensitivities of these techniques are 56, 42 and 77%. The preoperative diagnosis was correct in 18 patients (64%). The cyst was sometimes adherent to the underlying dura, then significantly increasing the risk of dural tear and spinal fluid leak, especially when located at L3-L4 level. Surgical ablation lead to a complete recovery or an important improvement in 26 patients. CONCLUSIONS: The diagnosis of the juxtafacet cyst of the lumbar spine is better achieved by MRI. Surgery is the gold standard treatment, safe and long-term effective. When a total cyst removal with an internal facetectomy are performed, recurrence is exceptional. [less ▲]

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See detailSocial cues and verbal framing in risky choice
Wang, X. T.; Simons, F.; Brédart, Serge ULg

in Journal of Behavioral Decision Making (2001), 14

We examined how people use social and verbal cues of differing priorities in making social decisions. In Experiment 1, formally identical life-death choice problems were presented in different ... [more ▼]

We examined how people use social and verbal cues of differing priorities in making social decisions. In Experiment 1, formally identical life-death choice problems were presented in different hypothetical group contexts and were phrased in either a positive or negative frame. The risk-seeking choice became more dominant as the number of kin in an endangered group increased. Framing effects occurred only in a heterogeneous group context where the lives at risk were a mixture of kin and strangers. No framing effect was found when the same problem was presented in the context of a homogeneous group consisting of either all kin or all strangers. We viewed the framing effects to be a sign of indecisive risk preference due to the differential effects of a kinship cue and a stranger cue on choice. In Experiment 2, we presented the life-death problem in two artificial group contexts involving either 6 billion human lives or 6 billion extraterrestrial lives. A framing effect was found only in the human context. Two pre-conditions of framing effects appear to be social unfamiliarity of a decision problem and aspiration level of a decision maker. In Experiment 3, we analyzed the direction of the framing effect by balancing the framing. The direction of the framing effect depended on the baseline level of risk preference determined by a specific decision conte [less ▲]

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See detailOptimisation des arcs paraboliques et en chaînette – aide à la conception sur base d'indicateurs morphologiques
Latteur, Pierre ULg; Samyn, Philippe; De Wilde, Patrick

in Revue Française de Génie Civil (2001), 5

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See detailBeta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae.
Conrath, K. E.; Lauwereys, M.; Galleni, Moreno ULg et al

in Antimicrobial Agents and Chemotherapy (2001), 45(10), 2807-12

Small, soluble single-domain fragments derived from the unique variable region of dromedary heavy-chain antibodies (VHHs) against enzymes are known to be potent inhibitors. The immunization of dromedaries ... [more ▼]

Small, soluble single-domain fragments derived from the unique variable region of dromedary heavy-chain antibodies (VHHs) against enzymes are known to be potent inhibitors. The immunization of dromedaries with the TEM-1 and BcII beta-lactamases has lead to the isolation of such single-domain antibody fragments specifically recognizing and inhibiting those beta-lactamases. Two VHHs were isolated that inhibit TEM-1 and one BcII inhibiting VHH was identified. All inhibitory VHHs were tight-binding inhibitors. The 50% inhibitory concentrations were determined for all inhibitors and they were all in the same range as the enzyme concentration used in the assay. Addition of the VHHs to the TEM-1 beta-lactamase, expressed on the surface of bacteria, leads to a higher ampicillin sensitivity of the bacteria. This innovative strategy could generate multiple potent inhibitors for all types of beta-lactamases. [less ▲]

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See detailÉvolution des accessibilités et des mobilités des localisations commerciales
Merenne-Schoumaker, Bernadette ULg

in Travaux de l’Institut de Géographie de Reims (2001), 27(107-108), 7-23

In order to be able to study the links between the evolution of accessibilities and mobilities and the dynamics of the commercial localizations, the article has been organized in three parts : firstly ... [more ▼]

In order to be able to study the links between the evolution of accessibilities and mobilities and the dynamics of the commercial localizations, the article has been organized in three parts : firstly, the definition of the concepts of accessibility and mobility as well as the distance; secondly, analysis of the role of these two concepts in the commercial field and the their most evident recent evolutions; lastly, research into corresponding links. On the basis of this work, everything indicates the priority of mobility over accessibility as well as very close relations between the mutations of urbanized territories and the installation of the new commercial framework, which is strongly governed by car mobility. [less ▲]

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See detailLes réserves d’interprétation dans la jurisprudence de la Cour d’arbitrage : une alternative à l’annulation
Rosoux, Géraldine ULg

in Revue Belge de Droit Constitutionnel (2001)

The article gives an overview upon constitutional decisions rejecting "under condition" actions for anulment.

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See detailDifferences in glucosinolate degradation products related to aphid and Brassicaceae host plant myrosinases
Francis, Frédéric ULg; Wathelet, Jean-Paul ULg; Lognay, Georges ULg

in GCIRC Bulletin (2001)

Studies on chemical ecology of host plant selection by herbivores were largely carried out to orplain the diversity of secondary plant chemicals and host specialisation of herbivores. The glucosinolate ... [more ▼]

Studies on chemical ecology of host plant selection by herbivores were largely carried out to orplain the diversity of secondary plant chemicals and host specialisation of herbivores. The glucosinolate - isothiocyanate system in Brassicaceae plants was considered as a plant defence and was known to influence the feeding behaviour of phytophagous insects such as the cabbage aphid, Brevicoryre brassicae. Purified m5nosinases from the latter and from white mustard, Sinqis alba, were used to hydrolyse two glucosinolate compounds. Identification of the degradation products, mainly isothiocyanates, was perficrmed by gas chromatography - mass spectromeûy. While sinigdn hydrolysis gave identical isothiocyanates for insect and plant enzymes, B. brassicae myrosinase showed a particular activity toward sinalbin A lost of an hydrory group was obsen'red for the two latter substrates related products when compared to the S. alba enzymatic specificity. Aphid and plant myrosinases have different properties and specificities which can be discussed in relation to a co-evolution approach. [less ▲]

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See detailEarly retirement in Europe: A call for action
Jousten, Alain ULg

in CESIFO Forum (2001), 4

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See detailLes troubles des fonctions exécutives dans la maladie d'Alzheimer
Collette, Fabienne ULg; Van der Linden, Martial ULg

in Alzheimer Actualités (2001), (155), 6-9

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See detailLa crise argentine : faillite d’un système et crise géopolitique ?
Santander, Sébastian ULg

in Cahiers des Ameriques Latines (2001), 38/3

La crise qui cuvait depuis plus de trois ans en Argentine et qui a éclaté au grand jour en décembre 2001 a occasionné d'importantes conséquences pour la politique étrangère du pays et partant des ... [more ▼]

La crise qui cuvait depuis plus de trois ans en Argentine et qui a éclaté au grand jour en décembre 2001 a occasionné d'importantes conséquences pour la politique étrangère du pays et partant des mutations géopolitiques régionales. [less ▲]

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See detailSens de la cohérence, colère et trouble obsessionnel-compulsif
Lambert, Stéphanie; Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Francophone de Clinique Comportementale et Cognitive (2001), 6(4), 5-16

This study assesses the relationship between the Sense of Coherence (SoC) of Antonovsky, anger and the obsessive-compulsive disorder. The sample is composed of 42 subjects divided in two groups, 21 ... [more ▼]

This study assesses the relationship between the Sense of Coherence (SoC) of Antonovsky, anger and the obsessive-compulsive disorder. The sample is composed of 42 subjects divided in two groups, 21 subjects suffering of obsessive-compulsive disorder and 21 subjects matched controls. They completed a demographic questionnaire, the list of obsessions and compulsions of Goodman & al.(1989), translation Mollard, Cottraux & Bouvard (1989), the Visual Analogues Scales, the Orientation Life Questionnaire of Antonovsky (1987), the State-Trait Anger Expression Inventory of Spielberger (STAXI), the State-Trait Anxiety Inventory of Spielberger (STAI), and the Beck Depression Inventory (BDI). The results show higher scores of anxiety and depression in obsessive-compulsive patients than in controls subjects. According to the results obtained with the Anger Inventory, the obsessive-compulsive subjects show higher scores of state-anger, of anger-expression and higher scores of anger-control. The results of the Sense of Coherence scale reveal a lower SoC in TOC group than in control group. The SoC is also negatively associated with depression and anxiety in both groups. The SoC is negatively associated with the control of anger in the TOC group and with the suppression of anger in the control group. The theorical and clinical implications of these results are discussed. [less ▲]

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See detailGeometrical considerations for evaluation of reserve design.
Bogaert, Jan ULg; Salvador-Van Eysenrode, D; Van Hecke, P et al

in Web Ecology (2001), (2), 65-70

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See detailTransplantation pulmonaire et fonction mitochondriale
Detry, Olivier ULg; Willet, K.; Meurisse, Michel ULg et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(6, Pt 2), 355-9

The mechanisms of cellular lesions induced by lung ischemia and reperfusion are not fully understood and, in particular, the consequences of pulmonary ischemia and reperfusion injury on mitochondrial ... [more ▼]

The mechanisms of cellular lesions induced by lung ischemia and reperfusion are not fully understood and, in particular, the consequences of pulmonary ischemia and reperfusion injury on mitochondrial function have not been previously investigated. Therefore, we studied the respiratory function of isolated pulmonary mitochondria in a swine model of lung ischemia and reperfusion. We demonstrated that prolonged hypothermic (4 degrees C) ischemia induces significant lesions of the mitochondrial respiratory chain, particularly if ischemia is followed by normothermic reperfusion. These results should be integrated in the cellular alterations induced by the ischemia-reperfusion injury. In another swine model mimicking controlled non-heart beating donors, we demonstrated that thirty minutes of cardiac arrest do not promote significant alteration of the mitochondrial respiratory function. In contrast, forty-five minutes of cardiac arrest, induced significant mitochondrial lesions. This pulmonary tolerance to normothermic cardiac arrest might be explained by the presence of air in the lung airways, allowing some aerobic metabolism after circulatory arrest. These results suggested that lung grafts might be harvested from non-heart beating donors after thirty minutes of cardiac arrest, significantly increasing the pulmonary graft pool. [less ▲]

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See detailInfluence of nonlocal electrodynamics on the anisotropic vortex pinning in YNi2B2C
Silhanek, Alejandro ULg; Thompson, J. R.; Civale, L. et al

in Physical Review. B : Condensed Matter (2001), 64(1),

We have studied the pinning force density F-p of YNi2B2C superconductors for various field orientations. We observe anisotropies both between the c axis and the basal plane and within the plane that ... [more ▼]

We have studied the pinning force density F-p of YNi2B2C superconductors for various field orientations. We observe anisotropies both between the c axis and the basal plane and within the plane that cannot be explained by the usual mass anisotropy. For magnetic field H parallel toc, the reorientation structural transition in the vortex lattice due to nonlocality, which occurs at a field H(1)similar to1 kOe, manifests itself as a kink in F-p(H). When H perpendicular toc, F-p is much larger and has a quite different H dependence, indicating that other pinning mechanisms are present. In this case the signature of nonlocal effects is the presence of a fourfold periodicity of F-p within the basal plane. [less ▲]

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See detailSensitivity analysis of longitudinal binary quality of life data with drop-out: an example using the EORTC QLQ-C30
Van Steen, Kristel ULg; Curran, D.; Molenberghs, G.

in Statistics in Medicine (2001), 20(24), 3901-20

Analysing quality of life data (QOL) may be complicated for several reasons. Quality of life data not only involves repeated measures but is also usually collected on ordered categorical responses. In ... [more ▼]

Analysing quality of life data (QOL) may be complicated for several reasons. Quality of life data not only involves repeated measures but is also usually collected on ordered categorical responses. In addition, it is evident that not all patients provide the same number of assessments, due to attrition caused by death or other medical reasons. In the recent statistical literature, increasing attention is given to methods which can handle non-continuous outcomes in the presence of missing data. The aim of this paper is to investigate the effect on statistical conclusions of applying different modelling techniques to QOL data generated from an EORTC phase III trial. Treatment effects and treatment differences are of major concern. First, a random-effects model is fitted, relating a binary longitudinal response (derived from the physical functioning scale of the QLQ-C30) to several covariates. In a second approach, marginal models are fitted, retaining the response variable and the mean structure used before. The fitted marginal models only differ with respect to the considered estimation procedure: generalized estimating equations (GEE); weighted generalized estimating equations (WGEE), and maximum likelihood (ML). [less ▲]

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See detailAutoimmune Pancreatitis Mimicking Cancer of the Head of Pancreas: Report of Two Cases
Servais, Anne-Marie ULg; Pestieau, Sophie R; Detry, Olivier ULg et al

in Acta Gastro-Enterologica Belgica (2001), 64(2, Apr-Jun), 227-30

Autoimmune pancreatitis has been characterised in 1995, but only a few cases have been published since then, most of them from Japan. This report describes the cases of two Belgian male patients who ... [more ▼]

Autoimmune pancreatitis has been characterised in 1995, but only a few cases have been published since then, most of them from Japan. This report describes the cases of two Belgian male patients who presented with isolated obstructive jaundice. Radiological imaging studies were highly suggestive of carcinoma of the head of pancreas and both patients underwent uneventful cephalic pancreaticoduodenectomy with portal vein resection. Pathological analysis of the removed tissues suggested an autoimmune process in both cases. Both patients had hyper-gammaglobulinemia and antinuclear antibodies, but failed to show evidence of any other autoimmune disease or cause of chronic pancreatitis. In both cases final diagnosis was autoimmune pancreatitis. Preoperative clinical suspicion of this diagnosis is mandatory and may avoid unnecessary surgery in future cases. [less ▲]

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See detailMorpho-anatomy of the otic region in carapid fishes : eco-morphological study of their otoliths
Parmentier, Eric ULg; Vandewalle, Pierre ULg; Lagardère, Françoise

in Journal of Fish Biology (2001), 58

Carapid species are characterized by so-called otophysical structures (sonic muscles, broad first apophyses covering the anterior part of the swimbladder, etc.) The family includes pelagic (Pyramodon and ... [more ▼]

Carapid species are characterized by so-called otophysical structures (sonic muscles, broad first apophyses covering the anterior part of the swimbladder, etc.) The family includes pelagic (Pyramodon and Snyderidia) and benthic (Echiodon) species and ones that are either commensal with (Onuxodon, Carapus) or parasites of (Encheliophis) invertebrates (sea cucumbers, etc). The aim of the present work was to seek possible relationships between the structures of the inner ear (particularly the sagitta) on the one hand and otophysical structures and lifestyles within the Carapidae family. In the eight species studied, the otic cavity is wide, the saccular otosac and its sagitta are particularly developed. The sacculi touch each other on the median line. A comparison of the inner ear structures reveals notably that the species with the most developed sagitta and sacculus are those with the largest parapophyses and have a commensal or parasitic lifestyle. [less ▲]

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See detailL'autonomie fiscale des communautés et des régions après les accords du Lambermont
Bourgeois, Marc ULg

in Actualités du Droit (2001)

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See detailHommage à M.D. Grmek
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2001), 35(4), 345-346

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See detailPreparation of low-density xerogels by incorporation of additives during synthesis
Alié, Christelle ULg; Ferauche, Fabrice; Pirard, René ULg et al

in Journal of Non-Crystalline Solids (2001), 289(1-3), 88-96

Low-density xerogels were prepared by incorporation of an additive to alcogels prior to gelation. The additives studied are 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS), 3 ... [more ▼]

Low-density xerogels were prepared by incorporation of an additive to alcogels prior to gelation. The additives studied are 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS), 3-aminopropyltrimethoxysilane (AMS), propyltrimethoxysilane (PMS), tetramethylorthosilicate (TMOS) and 3-aminopropyltriethoxysilane (AES) using tetraethylorthosilicate (TEOS) as main silica precursor. Samples were also prepared with EDAS as additive and TMOS as main silica reagent. When the additive contains methoxy groups, it reacts first, forms nuclei on which the main reagent TEOS reacts to form the silica particles. The nucleation mechanism by the additive occurs only in case of a difference of reactivity between additive and main silica precursor. The other group of the additive (amine, alkyl group, ...) influences only the gelation time. In case of ethoxy groups (series AES/TEOS) or methoxy groups (series EDAS/TMOS) for both additive and main reagent, there is no nucleation by the additive. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailRobust Validation of Measurements on jet Engines
Dewallef, Pierre ULg; Léonard, Olivier ULg

in European Journal of Mechanical and Environmental Engineering (2001), 46(4), 237-242

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the ... [more ▼]

Nowadays, most of turbine engine tests are processed using an open loop, i.e. the measurements are verified and treated a posteriori, sometimes weeks or months after the end of the test. The scope of the present project is to develop a new methodology which enables real time detection of faulty measurements and the suppression of the source of these faults during the test. This implies the development of a method which is sufficiently robust to cope with a lot of faulty data (up to 20 to 30 % of the measurements). Most of the existing methods make use of a least square approach so that a set of parameters is sought which minimizes the RMS error between the measurements and the values provided by a numerical model of the installation. This type of approach is efficient in finding whether a set of measurements is valid but cannot locate the fault(s). In this paper an alternative is proposed based on a distribution of the measurement noise introduced by Huber. This so-called robust validation method has been tested on a single spool, single flow and variable geometry nozzle turbojet. Both the least square and Huber's function approaches have been tested and compared in terms of efficiency. The robust estimator based on Huber's error function has shown to be much more powerful for both finding an invalid set of measurements and locating the faulty measurements. [less ▲]

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See detailIn vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators.
Henrotin, Yves ULg; de Leval, X.; Mathy, Marianne ULg et al

in Inflammation Research (2001), 50(8), 391-9

OBJECTIVES: To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4 ... [more ▼]

OBJECTIVES: To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes. METHODS: Enzymatically isolated human chondrocytes were cultured for 72 h in the absence or presence of interleukin-1beta (IL-1beta) or lipopolysacharride (LPS) and with or without increased amounts (1 to 30 microM) of aceclofenac or metabolites. The production of different cytokines was measured by Enzyme Amplified Sensitivity Immunoassays (EASIA). Prostaglandin E2 was quantified by a specific radioimmunoassay. Nitrite and nitrate concentrations in the culture supernatants were determined by spectrophotometric method based upon the Griess reaction. Cyclooxygenase-2, inducible NO synthase and IL-1beta gene expression were quantified by reverse transcription of mRNA followed by real time and quantitative polymerase chain reaction. Finally, cyclooxygenase inhibitory potency of the drugs was also tested in both a cell-free system using purified ovine cyclooxygenase-1 and -2 (COX-1 and COX-2) and at a cellular level using human whole blood assay. RESULTS: We have demonstrated that aceclofenac, 4'-hydroxyaceclofenac and diclofenac significantly decreased interleukin-6 production at concentrations ranged among 1 to 30 microM and fully blocked prostaglandin E2 synthesis by IL-1beta- or LPS-stimulated human chondrocytes. Aceclofenac and diclofenac had no effect on interleukin-8 production while 4'-hydroxyaceclofenac slightly decreased this parameter at the highest dose (30 microM). Aceclofenac was without effect on IL-1beta- or LPS-stimulated nitric oxide production. At 30 microM, 4'-hydroxyaceclofenac inhibited both IL-1beta or LPS-stimulated nitric oxide production while diclofenac inhibited only the LPS-stimulated production. Finally, at 30 microM, the three drugs significantly decreased IL-1beta mRNA. In the whole blood test, aceclofenac and 4'-hydroxyaceclofenac weakly inhibited COX-1 with IC50 values superior to 100 microM, but decreased by 50% COX-2 activity at the concentration of 0.77 and 36 microM, respectively. Diclofenac strongly inhibited both COX-1 and COX-2 with IC50 values of 0.6 and 0.04 microM, respectively. On the other hand, aceclofenac and diclofenac weakly inhibited purified ovine cyclooxygenases with IC50 values superior to 100 microM, whereas 4'-hydroxyaceclofenac was without effect. CONCLUSIONS: These results suggest that aceclofenac actions are multifactorial and that metabolites could contribute to its anti-inflammatory actions. [less ▲]

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See detailCompact and portable holographic camera using photorefractive crystals. Application in various metrological problems
Georges, Marc ULg; Scauflaire, Véronique; Lemaire, Philippe

in Applied Physics B : Lasers & Optics (2001), 72

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See detailEtude clinique du mois. Protection secondaire de l'accident vasculaire cerebral par le perindopril: l'etude PROGRESS.
Scheen, André ULg

in Revue Médicale de Liège (2001), 56(11), 792-5

PROGRESS ("Perindopril pROtection aGainst REcurrent Stroke Study") demonstrated that blood-pressure lowering treatment with perindopril, an angiotensin converting enzyme inhibitor (combined with the ... [more ▼]

PROGRESS ("Perindopril pROtection aGainst REcurrent Stroke Study") demonstrated that blood-pressure lowering treatment with perindopril, an angiotensin converting enzyme inhibitor (combined with the diuretic agent indapamide when necessary), reduces the risk of stroke by 28% (95% CI: 17-38, p < 0.0001) among patients with a history of stroke or transient ischaemic attack. This protective effect was observed among both hypertensive and non-hypertensive individuals. It was more marked in the patients receiving combined perindopril + indapamide treatment (-43%; 95% CI 30-54) who were those who showed the greatest reduction in arterial blood pressure (-12/5 mm Hg). According to these observations, the authors concluded that treatment with these two agents should now be considered routinely for patients with a history of stroke or transient ischaemic attack, irrespective of their blood pressure. [less ▲]

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See detailBabel enfer
Durand, Pascal ULg

in Série Léon Bloy (2001)

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See detailA self-consistent model of the Jovian auroral thermal structure
Grodent, Denis ULg; Waite, J. Hunter; Gérard, Jean-Claude ULg

in Journal of Geophysical Research (2001), 106(A7), 12933-12952

A one-dimensional (1-D) model coupling a two-stream electron transport model of energy deposition with a 1-D thermal conduction model has been developed. It is applied to investigate the links between ... [more ▼]

A one-dimensional (1-D) model coupling a two-stream electron transport model of energy deposition with a 1-D thermal conduction model has been developed. It is applied to investigate the links between auroral heat input and the vertical temperature of Jupiter's upper atmosphere. Two energy distributions meant to reproduce the emissions of a diffuse and a discrete aurora are used to evaluate the importance of the energy spectrum of the incident electrons for the thermal balance of Jupiter's auroral thermosphere. The values of observable quantities such as the altitude of the H-2 emission peak, thermal infrared (LR), ultraviolet (UV) emissions, and temperatures associated with various optical signatures are used to constrain the parameters of these distributions. It is shown that the high-energy component of these energy distributions heats a region of the homosphere between 10(-4) and 10(-6) bar and mainly controls the H-2 temperature and the far-UV (FUV) emission. A 3-keV soft electron component is necessary to heat the region directly above the homopause, between 10(-6) and 10(-9) bar. It has a large influence on the H-2 and H-3(+) temperatures and on the H-3(+) near-IR(NIR) emission. It is used in conjunction with a weak 100 eV component which is responsible for heating the thermosphere, from 10(-9) to 10(-12) bar and exerts a control on the exospheric temperature. The calculated temperatures, UV, and IR emissions suggest that the model probably misses a nonparticle heat source in the 10(-5) bar region, that is expected to balance the strong hydrocarbon cooling. Sensitivity tests are performed to evaluate the importance of the parameters of the energy distributions. They show that the FUV color ratio increases with the characteristic energy (or high-energy cutoff) of the high-energy component, while the H-2 rovibrational temperature varies inversely. A trade-off is therefore necessary for these two parameters to simultaneously meet their observational constraints. Further tests demonstrate the essential thermostatic role played by H-3(+), which regulates the net heating in the thermosphere. An increased eddy diffusion reproduces the effect of a possible auroral upwelling of methane but gives rise to an H-2 temperature smaller than the observed value. [less ▲]

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See detailDevelopment of a test battery for assessing cognitive functions of elderly patients with Down syndrome
Georges, Michel ULg; Thewis, B.; Van der Linden, Martial ULg et al

in Revue de Neuropsychologie (2001), 11(4), 549-579

Post-mortem studies of Down syndrome (DS) individuals older than 35 years show that almost 100% of them develop the neuropathological symptoms of Alzheimer disease (AD). A test battery designed to assess ... [more ▼]

Post-mortem studies of Down syndrome (DS) individuals older than 35 years show that almost 100% of them develop the neuropathological symptoms of Alzheimer disease (AD). A test battery designed to assess several domains of cognition was administered to a group of 12 DS individuals older than 35 years. It proved sensitive to individual differences and thus appears to be appropriate for the observation of cognitive change linked to age. Statistical analyses do not reveal cognitive changes in the DS subjects after one year time. However qualitative analyses of individual profiles suggest a cognitive decline in one subject. Additionally, in a PET-scan examination, three subjects present a mild decrease in cerebral glucose metabolism similar to that usually observed in AD. An AD diagnostic though remains uncertain at this stage. [less ▲]

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See detailThe use of additives to prepare low-density xerogels
Alié, Christelle ULg; Pirard, René ULg; Lecloux, A. J. et al

in Journal of Non-Crystalline Solids (2001), 285

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See detailYoung Investigators Workshop participants (P.A Coucke) and N. Coleman : Radiation Research program, Radiation Oncology Sciences Program, National Cancer Institue, Nih, August 1-2, 2000
Coucke, Philippe ULg

in International Journal of Radiation, Oncology, Biology, Physics (2001), 49(5), 1505-1516

INTRODUCTION The one-and-a-half day Young Investigators Workshop was held in the Holiday Inn, Bethesda, August 1–2, 2000. Using the SCAROP mailing list and recommendations from department chiefs ... [more ▼]

INTRODUCTION The one-and-a-half day Young Investigators Workshop was held in the Holiday Inn, Bethesda, August 1–2, 2000. Using the SCAROP mailing list and recommendations from department chiefs, approximately 55 “early-career” physicianscientists were invited to attend the workshop. Table 1 includes the participants. The goals of the meeting were: c To bring together radiation oncology physician-scientists who were in the early part of their career to discuss research ideas and opportunities as well as potential barriers to progress for the field and for young-investigator careers. c To help develop camaraderie among and a critical-mass of a new generation of physician-scientists with interests ranging from technology development, to basic and translational research, to outcomes research and analysis. c To help the young investigators gain familiarity with the NIH grant programs. c To prepare a “white paper” with their vision and ideas for potential opportunities for the future. If possible, a shortand long-term agenda were to be proposed. The first morning included presentations from a variety of NCI programs. Three breakout sessions were held in the afternoon. Breakout Group Reports were discussed by the entire group the following morning. A fourth discussion topic on “Barriers To a Successful Research Career” was conducted by the entire group. Drafts of this entire Workshop Report were circulated to the participants. The final document represents the efforts of the entire Young Investigators Workshop and provides the perspective from the point of view of the investigators who have many years to invest in the future of radiation oncology. The Radiation Research Program (RRP) is grateful to all the participants for a lively workshop and to the session co-chairs for the timely preparation of this report. [less ▲]

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See detailSpectroscopic evidence for high-altitude Aurora at Jupiter from Galileo Extreme Ultraviolet Spectrometer and Hopkins Ultraviolet Telescope observations
Ajello, Joseph M.; Shemansky, D. E.; Pryor, Wayne R. et al

in Icarus: International Journal of Solar System Studies (2001), 152(1), 151-171

The Galileo Extreme Ultraviolet Spectrometer (EUVS) and the Hopkins Ultraviolet Telescope (HUT) acquired UV spectra of Jupiter Aurora in the period from 1995 through 1997, The EUVS spectra spanned the ... [more ▼]

The Galileo Extreme Ultraviolet Spectrometer (EUVS) and the Hopkins Ultraviolet Telescope (HUT) acquired UV spectra of Jupiter Aurora in the period from 1995 through 1997, The EUVS spectra spanned the wavelength range 540-1280 Angstrom and the HUT spectra measured the extreme ultraviolet and far ultraviolet (EUV + FUV) wavelength range 830-1850 Angstrom. Both sets of spectra present evidence of high-altitude, optically thin H-2 band emissions from the exobase region, The analysis of the UV spectra with a two-stream electron transport model and a jovian model auroral atmosphere indicates that the primary electron flux is composed of both soft and hard electrons with characteristic energies in the soft electron energy range of 20-200 eV and the hard electron range of 5-100 keV, The soft electron flux causes enhanced EUV emission intensities below 1100 Angstrom. The soft electron flux may explain the high temperature of the upper atmosphere above the homopause as measured from Il: rovibrational temperatures in the IR. For the deep aurora, a high primary characteristic energy above 5 keV is known to be present. The Galileo Energetic Particle Detector (EPD) has measured the electron distribution functions for energies above 15 keV in the middle magnetosphere. The high-energy distribution functions can be modeled by a combination of Maxwellian and kappa distributions. However, the EUV (800-1200 Angstrom) portion of the HUT spectrum cannot be modeled with a single distribution of hard electrons as was possible in the past for the FUV (1200-1650 Angstrom) spectrum measured by itself, The combination of EUV and FUV spectral observations by HUT serves to identify the amount of soft electron flux relative to the hard primary flux required to produce the high-altitude aurora in the neighborhood of the exobase, (C) tool academic Press. [less ▲]

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See detailWhole-body positron emission tomography using 18F-fluorodeoxyglucose compared to standard procedures for staging patients with Hodgkin's disease.
Jerusalem, Guy ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in Haematologica (2001), 86(3), 266-73

BACKGROUND AND OBJECTIVES: Accurate staging is essential in order to determine appropriate treatment in Hodgkin's disease (HD). (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) offers ... [more ▼]

BACKGROUND AND OBJECTIVES: Accurate staging is essential in order to determine appropriate treatment in Hodgkin's disease (HD). (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) offers the advantage of metabolic imaging that is largely independent of morphologic criteria. In the present study we evaluated the role of (18)F-FDG PET compared to routine procedures for the staging of patients with HD. DESIGN AND METHODS: Thirty-three patients with HD underwent standard staging procedures (clinical examination, laboratory screening, chest X-ray, computed tomography (CT) of the chest and abdomen and bilateral bone marrow biopsies) and a whole-body (18)F-FDG PET study. In clinical examination, an isolated lymph node > 1 cm or multiple lymph nodes > or = 1 cm in size were considered abnormal. Positive findings at both clinical examination or CT and (18)F-FDG PET were regarded as actual locations of disease. Negative findings with both methods were regarded as true negative (no involvement by HD). In cases of discrepancy, response to treatment and follow-up data were used to assess the overall accuracy of the patient's original evaluation. RESULTS: Completely concordant results in lymph node staging were observed in 20 patients. The two staging procedures indicated complementary information in 1 patient. Conventional staging indicated more pathologic lymph node areas in 6 patients (at least 1 false positive). (18)F-FDG PET showed more sites in 6 patients. The sensitivity of (18)F-FDG PET in detecting all known pathologic lymph nodes was 83% for peripheral lymph nodes, 91% for thoracic lymph nodes and 75% for abdominal and pelvic lymph nodes. Conventional staging procedures and (18)F-FDG PET indicated the same tumor stage in 26 patients. Based on (18)F-FDG PET, downstaging was suggested in 4 patients, including a biopsy-proven case. However in 1 of these cases this was incorrect. (18)F-FDG PET suggested upstaging in 3 patients. Based on conventional staging or (18)F-FDG PET the same treatment strategy was defined in 32 patients. In one patient (18)F-FDG PET downstaged disease extension (stage IIIA-->IIA) that would have suggested radiotherapy as a possible treatment option. INTERPRETATION AND CONCLUSIONS: (18)F-FDG PET provides an easy and efficient whole-body method for the evaluation of patients with HD. (18)F-FDG PET never missed tumor masses >1 cm. (18)F-FDG PET detected additional sites of disease not seen by conventional procedures and identified absence of disease in some sites suspected to be involved. However, in our patients this did not translate into changes in treatment strategy. [less ▲]

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See detailAn overlay tree building control protocol
Mathy, Laurent ULg; Canonico, R.; Hutchison, D.

in Networked Group Communication (2001)

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See detailLes insectes aquatiques du ru de Targnon (Commune de Theux)
Dethier, Michel; Dopagne, Claude ULg

in Natura Mosana (2001), 54(4), 67-76

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See detailRépercussions systémiques des infections parodontales: définition d'un nouvel index parodontal
Geerts, Sabine ULg; Rompen, Eric ULg

in Actualités Dentaires de l'Université de Liège (2001), 207

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See detailQuelques outils numériques de gestion des eaux de surface
Pirotton, Michel ULg; Lejeune, André ULg; Archambeau, Pierre ULg et al

in Bulletin de l'A.I.Lg (2001), (2), 29-31

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See detailTheoretical and experimental identification of a non-linear beam
Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg; Worden, K.

in Journal of Sound & Vibration (2001), 244

The identi"cation of the dynamic characteristics of linear systems is now widely used and interest in non-linear systems has increased. The objective of this paper is to demonstrate the performance of the ... [more ▼]

The identi"cation of the dynamic characteristics of linear systems is now widely used and interest in non-linear systems has increased. The objective of this paper is to demonstrate the performance of the restoring force surface method as far as the identi"cation of non-linear systems is concerned. The vibrations of a clamped beam are investigated for two di!erent kinds of non-linearity. Firstly, the beam shows a non-linear behaviour characterized by a piecewise linear sti!ness and secondly, the non-linearity comes from a bilinear sti!ness. Both numerical and experimental results are presented. (C) 2001 Academic Press [less ▲]

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See detailLe débiteur et le contenu d'une garantie sujets à discussion
Paris, Catherine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2001)

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See detailFour years of induction/synchronization of estrus in dairy goats: effect on the evolution of eCG binding rate in relation with the parameters of reproduction
Drion, Pierre ULg; Furtoss, V.; Baril, G. et al

in Reproduction Nutrition Development (2001), 41(5), 401-412

Ninety-eight Alpine goats of two herds were followed over 4 years in a program of annual artificial insemination after estrus induction/synchronization, including progestagen administration (vaginal ... [more ▼]

Ninety-eight Alpine goats of two herds were followed over 4 years in a program of annual artificial insemination after estrus induction/synchronization, including progestagen administration (vaginal sponge) followed by prostaglandin analog and equine chorionic gonadotrophin (eCG) 48 h before sponge removal. Goats were sampled every 4 hours from the 16th to the 56th following sponge removal, for determination of LH surge and tested for estrus by the presence of a buck. Seven days after AI, endoscopic examination of the ovaries was performed to determine the number of corpus lutea. Pregnancy diagnosis was performed at day 21-22 post AI by determination of plasma progesterone and at day 40-45 by ultrasonography. Parturition, number and sex of kids were recorded. All the goats were sampled before and after each treatment, for anti-eCG antibodies screening. Statistical analysis of the results clearly established a significant effect of the treatments on anti-eCG antibodies. Time of estrus and LH surge were significantly different between herd. The antibodies significantly delayed the time of coming out of estrus as well as the time of LH surge. Two antagonistic effects were evidenced: first, the delayed of time of estrus and time of LH surge in relation with the immune reaction to eCG; secondly, the ahead of time of estrus and time of LH surge during the years of treatment, identical to both herd. The antibodies negatively influenced the percentage of ovulating females as well as kidding rate. Finally, no effect of antibodies on prolificacy was found. [less ▲]

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See detailHIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.
Michiels, C.; Minet, E.; Michel, G. et al

in IUBMB Life (2001), 52(1-2), 49-53

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the ... [more ▼]

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively. [less ▲]

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See detailRadiothérapie vasculaire : un nouveau standard
Coucke, Philippe ULg; HU PHUOC DO; URBAN, Ph. et al

in Médecine et Hygiène (2001), 59(2342), 853-858

Le traitement des maladies cardiovasculalres, et plus spécifiquement la prise en charge des patients avec des sténoses vasculalres, qu'elles soient cardiaques ou périphériques, est en train d'être modifié ... [more ▼]

Le traitement des maladies cardiovasculalres, et plus spécifiquement la prise en charge des patients avec des sténoses vasculalres, qu'elles soient cardiaques ou périphériques, est en train d'être modifié de façon radicale. Avec l'Introduction des techniques d'angioplastie par vole transcutanée (PTCA) et la mise en place de « stents », on a certainement amélioré le devenir de ces malades. Toutefois, l'incidence de resténose après ces interventions endovasculaires reste élevée. Ce phénomène d'oblitération vasculaire après angloplastie ou stent s'explique en partie par des mécanismes de prolifération néointimale. On s'est donc logiquement tourné vers les radiations ionisantes comme alternative thérapeutique possible vu leur efficacité sur les processus de prolifération cellulaire, Autant pour les lésions de novo que les resténoses in-stent, on observe l'efficacité des radiations ionisantes. Les résultats des premiers essais randomisés ont été rendus publics et ceci va certainement changer les standards de prise en charge en cardiologie interventionnelle. [less ▲]

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See detailMagnetotransport properties of a single grain boundary in a bulk La-Ca-Mn-O material
Vertruyen, Bénédicte ULg; Cloots, Rudi ULg; Rulmont, André ULg et al

in Journal of Applied Physics (2001), 90(11), 5692-5697

Besides the "intrinsic" colossal magnetoresistance effect observed in single crystals, the polycrystalline manganate compounds also exhibit an "extrinsic" magnetoresistance related to the presence of ... [more ▼]

Besides the "intrinsic" colossal magnetoresistance effect observed in single crystals, the polycrystalline manganate compounds also exhibit an "extrinsic" magnetoresistance related to the presence of grain boundaries. We report electrical transport and magnetic measurements carried out on a bigrain sample extracted from a floating zone method-grown rod of calcium doped lanthanum manganate. Electrical resistance was measured both within a grain and across the grain boundary, between 20 and 300 K and from 0 to 8 T. Magnetoresistance values up to 99% are reached within the grain. The temperature dependence of the resistance across the grain boundary displays a "foot-like" feature towards the bottom of the transition. Low field and high field magnetoresistance effects are examined. We compare our results for a "bulk" grain boundary to those obtained by other authors for bicrystal thin films and bulk polycrystalline materials. (C) 2001 American Institute of Physics. [less ▲]

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See detailIntroduction générale aux techniques d'imagerie
Pirard, Eric ULg

in Techniques de l'Industrie Minérale (2001), 12

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See detailRole of interface deformations in Benard-Marangoni instability
Lebon, Georgy ULg; Dauby, Pierre ULg; Regnier, Vincent

in Acta Astronautica (2001), 48(5-12), 617-627

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See detailA thoughtful approach to brain tumours
Deprez, Manuel ULg

in Lancet (2001), Vol 358

Brain Tumours is a serious book, more than 1000 pages long, with 50 chapters, and the efforts of nearly 100 contributors. The editors begin by reminding us that surgery has always had a central role in ... [more ▼]

Brain Tumours is a serious book, more than 1000 pages long, with 50 chapters, and the efforts of nearly 100 contributors. The editors begin by reminding us that surgery has always had a central role in the management of brain tumours. However, surgical resection is often incomplete because of diffuse infiltration and the anatomical limits imposed by the surgical approach, or by proximity to the eloquent cortex. Incomplete resection undoubtedly contributes to tumour progression or recurrence, and the means to solve this dilemma lie in the collaborative effort of various medical and scientific disciplines. [less ▲]

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See detailStability of perturbed functional differential equations and stabilization of nonlinear cascades
Michiels, Wim; Sepulchre, Rodolphe ULg; Roose, Dirk

in SIAM Journal on Control & Optimization (2001), 40

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global ... [more ▼]

In this paper the effect of bounded input perturbation on the stability of nonlinear globally asymptotically stable delay differential equations is analyzed. We investigate under which conditions global stability in preserved and if not, whether semi-global stabilization is possible by controlling the size or shape of the perturbation. This results in a general framework, in which the stabilization of partial linear cascade systems using partial state feedback can be treated systematically. [less ▲]

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See detailSurvey of pigeonpea production systems, utilization and marketing in semi-arid lands of Kenya.
Mergeai, Guy ULg; Kimani, P.; Mwang'ombe, A. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(3), 145-153

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See detailPreparation of mebendazole HP-beta-cyclodextrin complexes using water-soluble polymers and organic acids
Alvarez, Covadonga; Van Hees, Thierry ULg; Piel, Géraldine ULg et al

in STP Pharma Sciences (2001), 11(6), 439-442

Mebendazole (MBZ) is a carbamate derivative with an aminobenzimidazole structure. It possesses antihelminthic properties and is particularly insoluble in water. In order to increase its aqueous solubility ... [more ▼]

Mebendazole (MBZ) is a carbamate derivative with an aminobenzimidazole structure. It possesses antihelminthic properties and is particularly insoluble in water. In order to increase its aqueous solubility, hydroxpropyl-beta-cyclodextrin (HP-beta-CD) was used in combination with water-soluble polymers (polyvinylpyrrolidone or hydroxypropymethyl cellulose) and different organic acids (citric or tartaric). Increased solubility was observed on heating the mixture. The effects of the time and temperature of the heating process on drug solubility and stability were investigated. The results clearly show that the best conditions for increasing solubility and limiting degradation of MBZ is to heat a combination of MBZ, HP-beta-CD (200 mM), tartaric or citric acid (50 mM) and HPMC (0.1% w/v) in a water-bath at 95degreesC for 60 min. This method increases solubility to about 680 mug/ml and limits degradation to 2.5%. [less ▲]

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See detailPAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.
Seither, P.; Iben, S.; Thiry, Marc ULg et al

in Biological Chemistry (2001), 382(8), 1163-70

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for ... [more ▼]

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for the functional differences of distinct fractions of cellular Pol I, and suggests that PAFs could be targets of regulatory pathways. Here we describe and functionally characterize PAF67, a novel 67 kDa protein that is tightly associated with a subpopulation of cellular Pol I. Both PAF67-containing and -deficient Pol I transcribe non-specific templates with similar efficiency, however, only the enzyme that contains PAF67 is capable of specifically transcribing rDNA templates. PAF67 co-localizes with Pol I in the nucleolus at sites of active rDNA transcription, indicating that PAF67 serves a role in rDNA transcription initiation. The results suggest that association of PAF67 with the 'core' enzyme endows Pol I with the capability to assemble into a productive transcription initiation complex at the rDNA promoter. [less ▲]

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See detailChanges in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin-independent rooting model
Tonon, Giustino; Kevers, Claire ULg; Gaspar, Thomas ULg

in Tree Physiology (2001), 21(10), 655-663

Among shoots of Fraxinus angustifolia Vahl raised in vitro, 76% rooted after culture on root induction medium for 5 days in darkness followed by culture on root expression medium for 15 days in light. The ... [more ▼]

Among shoots of Fraxinus angustifolia Vahl raised in vitro, 76% rooted after culture on root induction medium for 5 days in darkness followed by culture on root expression medium for 15 days in light. The addition of 20.7 muM indole-butyric acid (IBA) to the root induction medium did not significantly increase the rooting percentage (88%). Putrescine, spermidine, cyclohexylamine (CHA) and aminoguanidine (AG) enhanced rooting up to 100% (98.66% for AG), when applied during root induction in the absence of IBA, otherwise these compounds inhibited rooting, as did spermine and difluoromethylornithine (DFMO) + difluoromethylarginine (DFMA). The root induction phase was characterized by a temporary increase in endogenous free indole-acetic acid (IAA) and putrescine concentrations during root induction, whereas the root expression phase was characterized by increased peroxidase activity and low concentrations of polyamines. These changes were specifically associated with the rooting process and did not depend on the presence of exogenous IBA, because application of exogenous IBA enhanced the amount of IAA in the cuttings but did not affect rooting or the pattern of changes in polyamines and peroxidase. The effects of CHA, AG and DFMO + DFMA on endogenous concentrations of auxins and polyamines highlight the close relationship between the effects of IAA and putrescine in root induction and suggest that polyamine catabolism has an important role in root formation and elongation. [less ▲]

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See detailExperimental and theoretical lifetimes in Yb III
Zhang, Z. G.; Li, Z. S.; Svanberg, S. et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2001), 15

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See detailDe impact van Van Ostaijen. Een gesprek met Geert Buelens
Spinoy, Erik ULg; Willockx, Dietlinde; Peeters, Patrick

in Freespace Nieuwzuid (2001), 2(7), 3-28

This is the text of an interview with Geert Buelens, author of an important study of Paul van Ostaijen's influence on modern Flemish poetry.

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See detailExpression and function of the collagen receptor GPVI during megakaryocyte maturation.
Lagrue-Lak-Hal, A. H.; Debili, N.; Kingbury, G. et al

in Journal of Biological Chemistry (2001), 276(18), 15316-25

In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord ... [more ▼]

In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord blood derived CD34(+) cells. By flow cytometry, using an anti-GPVI monoclonal antibody or convulxin, a GPVI-specific ligand, GPVI was detected only on CD41(+) cells including some CD41(+)/CD34(+) cells, suggesting expression at a stage of differentiation similar to CD41. These results were confirmed at the mRNA level using reverse transcription-polymerase chain reaction. GPVI expression was low during megakaryocytic differentiation but increased in the more mature megakaryocytes (CD41(high)). As in platelets, megakaryocyte GPVI associates with the Fc receptor gamma chain (FcRgamma). The FcR gamma chain was detected at the RNA and protein level at all stages of megakaryocyte maturation preceding the expression of GPVI. The other collagen receptor, alpha(2)beta(1) integrin (CD49b/CD29), had a pattern of expression similar to GPVI. Megakaryocytic GPVI was recognized as a 55-kDa protein by immunoblotting and ligand blotting, and thus it presented a slightly lower apparent molecular mass than platelet GPVI (58 kDa). Megakaryocytes began to adhere to immobilized convulxin via GPVI after only 8-10 days of culture, at a time when megakaryocytes were maturing. At this stage of maturation, they also adhered to immobilized collagen by alpha(2)beta(1) integrin-dependent and -independent mechanisms. Convulxin induced a very similar pattern of protein tyrosine phosphorylation in megakaryocytes and platelets including Syk, FcRgamma, and PLC(gamma)2. Our results showed that GPVI is expressed early during megakaryocytic differentiation but functionally allows megakaryocyte adherence to collagen only at late stages of differentiation when its expression increases. [less ▲]

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See detailProgramme international pour le suivi des acquis des élèves (PISA) de l'OCDE
Lafontaine, Dominique ULg; Baye, Ariane ULg; Matoul, Anne ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2001), 7-8(7-8), 53-57

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See detailLa Position de la littérature congolaise dans l’ensemble des littératures africaines : une approche du cheminement de la pensée congolaise
Vanhaegendoren, Koen ULg

in Revue luxembourgeoise de littérature générale et comparée (2001)

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See detailEvaluation of aphidophagous ladybird populations in a vegetable crop and implications as biological agents
Francis, Frédéric ULg; Colignon, Pierre; Haubruge, Eric ULg et al

in Med. Fac. Landbouw. Univ. Gent (2001), 66(2a), 333-340

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See detailTranslocation Of The pAntp Peptide And Its Amphipathic Analogue Ap-2al
Drin, G.; Demene, H.; Temsamani, J. et al

in Biochemistry (2001), 40(6), 1824-34

The pAntp peptide, corresponding to the third helix of the homeodomain of the Antennapedia protein, enters by a receptor-independent process into eukaryotic cells. The interaction between the pAntp ... [more ▼]

The pAntp peptide, corresponding to the third helix of the homeodomain of the Antennapedia protein, enters by a receptor-independent process into eukaryotic cells. The interaction between the pAntp peptide and the phospholipid matrix of the plasma membrane seems to be the first step involved in the translocation mechanism. However, the mechanism by which the peptide translocates through the cell membrane is still not well established. We have investigated the translocation ability of pAntp through a protein-free phospholipid membrane in comparison with a more amphipathic analogue. We show by fluorescence spectroscopy, circular dichroism, NMR spectroscopy, and molecular modeling that pAntp is not sufficiently helically amphipathic to cross a phospholipid membrane of a model system. Due to its primary sequence related to its DNA binding ability in the Antennapedia homeodomain-DNA complex, the pAntp peptide does not belong to the amphipathic alpha-helical peptide family whose members are able to translocate by pore formation. [less ▲]

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See detailElement removal in harvested tree biomass: scenarios for critical loads in Wallonia, south Belgium
Bosman, Bernard ULg; Remacle, Jean; Carnol, Monique ULg

in Water, Air & Soil Pollution : Focus (2001), 1

The critical load concept is now widely used as a tool for developing emission control policies in Europe. As a signatory country of the Convention of Long-Range Transboundary Air Pollution, critical ... [more ▼]

The critical load concept is now widely used as a tool for developing emission control policies in Europe. As a signatory country of the Convention of Long-Range Transboundary Air Pollution, critical loads for acidity, nutrient nitrogen, nitrogen and sulphur have been calculated for the Flemish and Walloon regions in Belgium. This paper describes the methodology used for estimating critical loads for forest soils in the Walloon region according to the Steady-State Mass Balance equations. As an example the methodology was applied to the catchment `Waroneu', situated in a sensitive area of the Haute Ardenne. Main input parameters to the equations were derived from precipitation and runoff data of the catchment study. Improved estimates of nitrogen uptake (Nu) and base cation uptake (BCu) were obtained by intensive sampling of Picea abies and Quercus robur trees. Nutrient contents (Ca, Mg, K, N) and nutrient to nitrogen ratios of Picea abies reflected the poor soil quality at a site with high N deposition. Quercus robur nutrient contents increased from stem to higher order branches with a high proportion of nutrients located in the bark. However the simulation of stem only harvesting had a minor effect on critical loads. Measured wood densities were lower than reported literature values with a main effect on Nu and BCu estimates. The use of recommended default values and/or data derived from the experimental site resulted in a wide range of critical loads, some of which were largely overestimated. Results demonstrated the importance of site specific data for critical load calculations. [less ▲]

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See detailThe ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Thijs, Chantal et al

in Thrombosis and Haemostasis (2001)

This study shows that, during collagen-initiated platelet activation, the early secretion of ATP results in the activation of the P2X1 ion channel, which plays a role as a positive regulator of further ... [more ▼]

This study shows that, during collagen-initiated platelet activation, the early secretion of ATP results in the activation of the P2X1 ion channel, which plays a role as a positive regulator of further platelet responses. [less ▲]

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See detailTrophic diversiy within the eastern Weddell Sea amphipod community
Dauby, Patrick ULg; Scailteur, Yves; De Broyer, Claude

in Hydrobiologia (2001), 443

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See detailUretere retrocave chez un enfant de dix ans.
Kakanou, A.; NCHIMI LONGANG, Alain ULg; Ghuysen, M. S. et al

in Annales de Chirurgie (2001), 126(2), 156-8

Retrocaval ureter is an uncommon abnormality of the inferior vena cava, which is rarely detected in the child due to its non-specific symptomatology. Despite a varying state of severity, chronic ureteral ... [more ▼]

Retrocaval ureter is an uncommon abnormality of the inferior vena cava, which is rarely detected in the child due to its non-specific symptomatology. Despite a varying state of severity, chronic ureteral obstruction generally leads to the deterioration of renal function during adulthood. Treatment depends on the symptomatology in question, and surgical management should be as conservative as possible. [less ▲]

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See detailLe Romuleon en françois, traduction de Sébastien Mamerot.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (2001)

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See detailMolecular bases of the interaction between human prolactin and its membrane receptor: A ten year study
KINET, Sandrina; BERNICHTEIN, Sophie; LLOVERA, Marta et al

in Recent research developments in endocrinology (2001), 2

In this review, we make a chronologically overview of a project aimed at deciphering the molecular bases of the mechanism by which prolactin, a pituitary-secreted polypeptidic hormone, interacts with its ... [more ▼]

In this review, we make a chronologically overview of a project aimed at deciphering the molecular bases of the mechanism by which prolactin, a pituitary-secreted polypeptidic hormone, interacts with its membrane receptor, a member of the cytokine receptor superfamily. This study, based essentially on structural and mutational analysis of human prolactin, has identified two regions interacting with the receptor, named binding sites 1 and 2. We have also provided evidence that prolactin induces dimerization of its receptor through its two binding sites, and based on that mechanism of activation, we have engineered and characterized prolactin antagonists able to block the effect of the hormone by competition for receptor binding. Our study has also highlighted the importance of using well characterized bioassays to monitor such a structure-function study since the properties of a given hormone analog were shown to strongly differ depending on the bioassay used. [less ▲]

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See detailAutomatic time stepping algorithms for implicit numerical simulations of blade/casing interactions
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in International Journal of Crashworthiness (2001), 6(3), 351-362

An automatic time stepping algorithm for non-linear problems, solved by implicit schemes, is presented. The time step computation is based on the estimation of an integration error calculated from the ... [more ▼]

An automatic time stepping algorithm for non-linear problems, solved by implicit schemes, is presented. The time step computation is based on the estimation of an integration error calculated from the acceleration difference. It is normalised according to the size of the problem and the integration parameters. This time step control algorithm modifies the time step size only if the problem has a long time physical change. Additionally, the Hessian matrix can be kept constant for several iterations, even though the problem is non-linear. A criterion selecting if the Hessian matrix must be calculated or not is developed. Finally, a criterion of iterations divergence is also proposed. It avoids the determination, by the user, of a maximal iteration number. This minimises the total number of iterations, and thus the computation cost. Industrial numerical examples are presented that demonstrate the performances (precision and computational cost) of the algorithms. [less ▲]

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See detailL’administration publique et les technologies de l’information
Cornet, Annie ULg; Rondeaux, Giseline ULg

in Gestion : Revue Internationale de Gestion (2001), 26(1), 28-30

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See detailQuelques spécimens exceptionnels de premières plantes terrestres découvertes au Brésil (Bassin du Paraná, Dévonien basal)
Gerrienne, Philippe ULg; Milagres, I.; Bergamaschi, S. et al

in Geo-Eco-Trop (2001), 25

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See detailAvancées récentes en biologie moléculaire du virus de la diarrhée virale bovine
Dehan, Pierre ULg; Hamers, C.; Couvreur, B. et al

in Annales de Médecine Vétérinaire (2001), 145

Detailed reference viewed: 22 (6 ULg)