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See detailThe Beta-Lactamase Cycle: A Tale of Selective Pressure and Bacterial Ingenuity
Matagne, André ULg; Dubus, Alain; Galleni, Moreno ULg et al

in Natural Product Reports (1999), 16(1), 1-19

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See detailLe cas clinique du mois. Prolapsus sur dégénérescence fibro-élastique. Les "cheveux blancs" de la valvule mitrale
Radermecker, M. A.; Hoffer, E.; Pierard, Luc ULg et al

in Revue Médicale de Liège (1999), 54(2), 76-8

We report the case of a 73-year-old woman who presents an acute mitral regurgitation secondary to fibro-elastic degenerescence. A mitral valvuloplasty is rapidly performed with complete disappearance of ... [more ▼]

We report the case of a 73-year-old woman who presents an acute mitral regurgitation secondary to fibro-elastic degenerescence. A mitral valvuloplasty is rapidly performed with complete disappearance of valvular insufficiency and the patient leaves the hospital ten days later. Degenerative mitral regurgitation is commonly seen in elderly patients. This constitutes an excellent indication for mitral valvuloplasty, rather than valve replacement. In our experience, mitral valvuloplasty leads to a complete correction of valvular regurgitation without neither stenosis, nor subvalvular obstruction. Left ventricular function is preserved, as subvalvular apparatus is conserved. This approach allows, in the absence of specific indication, anticoagulation withdrawn two to three months later. [less ▲]

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See detailTypical Presentation of Intramural Aortic Haemorrhage (Iah) with Evidence of Intimal Tear at Mri and Angiography
RADERMECKER, Marc ULg; LAVIGNE, Jean-Paul ULg; Limet, Raymond ULg

in Acta Chirurgica Belgica (1999), 99(1), 44-6

A typical appearance of IAH was evidenced by CT and TEE in a 56-year-old hypertensive female suspected of developping classical acute aortic dissection (AAD). Further examination with MRI and aortography ... [more ▼]

A typical appearance of IAH was evidenced by CT and TEE in a 56-year-old hypertensive female suspected of developping classical acute aortic dissection (AAD). Further examination with MRI and aortography showed unequivocally the presence of an intimal tear in the aortic arch. This coexistence of intimal tear has never been evidenced preoperatively in patients with IAH. This observation demonstrates at the outset that IAH is part of the spectrum of AAD. [less ▲]

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See detailControl of Dioscorea alata microtubers dormancy and germination by jasmonic acid
Bazabakana, R.; Fauconnier, Marie-Laure ULg; Jaziri, M. et al

in Plant Growth Regulation (1999), 27(2), 113-117

Effects of appling exogenous jasmonic acid (JA) on the germination of Dioscorea alata L. microtubers were examined on Murashige and Skoog (MS) medium. Microtuber germination was promoted by JA (0.1 and 1 ... [more ▼]

Effects of appling exogenous jasmonic acid (JA) on the germination of Dioscorea alata L. microtubers were examined on Murashige and Skoog (MS) medium. Microtuber germination was promoted by JA (0.1 and 1 µM) supplemented to the culture medium but higher concentrations (30 and 100 µM) completely inhibited germination. When these inhibited microtubers were transferred to hormone-free medium, germination resumed. After transfer to greenhouse conditions, almost all plants (95%) from tubers previously cultivated on MS medium with 100 µM JA survived and all acclimatized plants had produced tubers after 8 months. It is concluded that depending on JA concentration, both the germination and dormancy processes in D. alata microtubers were affected. The release from dormancy is easily obtained by transferring dormant microtubers to hormone-free medium. [less ▲]

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See detailPrognostic factors in patients with Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. Groupe d'Etude des Neoplasies Endocriniennes Multiples (GENEM and groupe de Recherche et d'Etude du Syndrome de Zollinger-Ellison (GRESZE).
Cadiot, G.; Vuagnat, A.; Doukhan, I. et al

in Gastroenterology (1999), 116(2), 286-293

BACKGROUND & AIMS: Risk factors of metachronous liver metastases and death are not well known in patients with the Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. These factors were ... [more ▼]

BACKGROUND & AIMS: Risk factors of metachronous liver metastases and death are not well known in patients with the Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. These factors were retrospectively determined in 77 patients. METHODS: Data chart review was performed. RESULTS: Median follow-up was 102 months (range, 12-366). Surgery was performed on 48 patients, including 9 of the 10 patients with large pancreatic tumors (>/=3 cm). Liver metastases developed in 4 patients (40%) with large pancreatic tumors, in 3 (4.8%) without, and in 1 of the 4 patients with pancreatic tumors of unknown size; all had previously undergone surgery. The only independent factor associated with development of liver metastases identified by multivariate analysis was large pancreatic tumors (risk ratio, 29.0; 95% confidence interval [CI], 3. 2-260.7). Surgery was not selected. The probability of being free of liver metastases in the 63 patients without large pancreatic tumors was 96% (95% CI, 88-100) at 10 and 15 years. Thirteen (16.9%) patients died. The only independent factors of death selected by multivariate analysis were Zollinger-Ellison syndrome diagnosis before 1980 (risk ratio, 8.2; 95% CI, 1.7-40.6) and age at diagnosis (risk ratio/year, 1.08; 95% CI, 1.03-1.14). CONCLUSIONS: Large pancreatic tumors are predictive of the development of metachronous liver metastases, and surgery does not seem to prevent them. [less ▲]

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See detailEeuwige vragen? Over Mooi, maar dat is het woord niet van Rutger Kopland
Spinoy, Erik ULg

in Neerlandica Extra Muros (1999), 37(1), 53-58

This article is a critical survey of the literary views held by the Dutch poet Rutger Kopland.

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See detailEffects of Training on Exercise-Induced Muscle Damage and Interleukin 6 Production
Croisier, Jean-Louis ULg; Camus, G.; Venneman, Ingrid ULg et al

in Muscle & Nerve (1999), 22(2), 208-12

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male ... [more ▼]

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed-onset muscle soreness; DOMS), and by significant increases in plasma IL-6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL-6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise-induced muscle damage and increased postexercise levels of circulating IL-6 is not substantiated by the present results. [less ▲]

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See detailLoss of the Y Chromosome in Bone Marrow Cells: Results on 1907 Consecutive Cases of Leukaemia and Preleukaemia
Herens, Christian ULg; Brasseur, Edmond ULg; Jamar, Michelle ULg et al

in Clinical & Laboratory Haematology (1999), 21(1), 17-20

Loss of the Y chromosome with a resulting 45, X0 karyotype is observed in normal bone marrow cells of elderly males but also in haematological malignancies. Whether Y loss in neoplastic cells is related ... [more ▼]

Loss of the Y chromosome with a resulting 45, X0 karyotype is observed in normal bone marrow cells of elderly males but also in haematological malignancies. Whether Y loss in neoplastic cells is related to the process seen in normal ageing or is part of the carcinogenic process is unknown. The present study concerns the cytogenetic data from 1907 consecutive leukaemic or preleukaemic male patients with special regard to the presence or absence of the Y chromosome. Sixty-five patients (3.4%) had a 45, X-Y clone in their bone marrow (BM) cells. Loss of Y was rare below the age of 50 but increased in older patients, reaching 25% of the men over 80. Sixteen patients (0.08%) had more than 90% X0 cells in their BM. A correlation between Y loss and leukaemia could be established in seven cases, three of which were acute myeloid leukaemia M2 subtype where -Y is known to be a secondary event. In three other cases, -Y was part of a complex karyotype. Only one patient exhibited a 45, X0 karyotype, with no other rearrangement, that could be positively correlated with the neoplastic process. [less ▲]

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See detailChronic Herpes Simplex Virus Type I Glossitis in an Immunocompromised Man
Nikkels, Arjen ULg; Pierard, Gérald ULg

in British Journal of Dermatology (1999), 140(2), 343-346

Herpes simplex virus (HSV) type 1 (HSV-1) infection of the tongue commonly accompanies acute primary herpetic gingivostomatitis. However, recurrent infection of the tongue is exceptional and is restricted ... [more ▼]

Herpes simplex virus (HSV) type 1 (HSV-1) infection of the tongue commonly accompanies acute primary herpetic gingivostomatitis. However, recurrent infection of the tongue is exceptional and is restricted to immunocompromised individuals. A 57-year-old man with corticosteroid-dependent chronic obstructive pulmonary disease and sciatica presented with a chronic median glossitis due to HSV-1. The main clinical and histological feature was massive necrosis of the entire mucosa. Immunohistochemistry demonstrated a considerable amount of HSV gB, gC and gD envelope glycoproteins dispersed in the chorion. In contrast, HSV-1 DNA was detected only in a limited number of epithelial cells using in situ hybridization. The extent of necrosis and the pattern of viral DNA and envelope protein distribution represent unique features of median herpetic glossitis, which are not found in more common types of HSV infection. [less ▲]

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See detailoncologie gastro-intestinale
Frei, A.; Coucke, Philippe ULg; Felley, C. et al

in Revue Médicale Suisse (1999), 760

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See detailInteraction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases
Prosperi-Meys, C.; Llabres, Gabriel ULg; De Seny, Dominique ULg et al

in FEBS Letters (1999), 443(2), 109-11

The most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders ... [more ▼]

The most widely used inactivators of active-site serine beta-lactamases behave as substrates of four class B metallo-beta-lactamases, but the efficiency of the catalytic process can vary by several orders of magnitude. A comparison of the kinetic parameters for the alpha and beta isomers of 6-iodopenicillanic acid shows that there is no general preference for the alpha isomer and that the efficient hydrolysis of imipenem by these enzymes must rest on other factors. [less ▲]

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See detailPolar stratospheric descent of NOy and CO and Arctic denitrification during winter 1992-1993
Rinsland, C. P.; Salawitch, R. J.; Gunson, M. R. et al

in Journal Of Geophysical Research. Atmospheres (1999), 104(D1), 1847-1861

Observations inside the November 1994 Antarctic stratospheric vortex and inside the April 1993 remnant Arctic stratospheric vortex by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier transform ... [more ▼]

Observations inside the November 1994 Antarctic stratospheric vortex and inside the April 1993 remnant Arctic stratospheric vortex by the Atmospheric Trace Molecule Spectroscopy (ATMOS) Fourier transform spectrometer are reported. In both instances, elevated volume mixing ratios (VMRs) of carbon monoxide (CO) were measured. A peak Antarctic CO VMR of 60 ppbv (where 1 ppbv = 10(-9) per unit volume) was measured at a potential temperature (Theta) of 710 K (similar to 27 km), about 1 km below the altitude of a pocket of elevated NOy (total reactive nitrogen) at a deep minimum in N2O (<5 ppbv). The Arctic observations also show a region of elevated vortex CO with a peak VMR of 90 ppbv at 630-670 K (similar to 25 km) but no corresponding enhancement in NOy, perhaps because of stronger dynamical activity in the northern hemisphere polar winter and/or interannual variability in the production of mesospheric NO. By comparing vortex and extravortex observations of NOy obtained at the same N2O VMR, Arctic vortex denitrification of 5 +/- 2 ppbv at 470 K (similar to 18 km) is inferred. We show that our conclusion of substantial Arctic winter 1992-1993 denitrification is robust by comparing our extravortex observations with previous polar measurements obtained over a wide range of winter conditions. Correlations of NOy with N2O measured at the same Theta by ATMOS in the Arctic vortex and at midlatitudes on board the ER-2 aircraft several weeks later lie along the same mixing line. The result demonstrates the consistency of the two data sets and confirms that the ER-2 sampled fragments of the denitrified Arctic vortex following its breakup, An analysis of the ATMOS Arctic measurements of total hydrogen shows no evidence for significant dehydration inside the vortex. [less ▲]

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See detailModifier l'utilisation/la destination d'un bâtiment, en Région wallonne
Delnoy, Michel ULg

in Immobilier (1999), 2

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See detailSynthesis and bulk characterization of new P(CB-b-S) diblock copolymers
Stone, V. W.; Jonas, Alain M; Legras, Roger et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1999), 37(2), 233-244

Strongly asymmetric chlorinated polybutadiene-b-polystyrene, [P((CB)x-b-(PS)y)] diblock copolymers with increasing x/(x + y) ratios (up to 5.2 mol %) have been synthesized by the selective chlorination of ... [more ▼]

Strongly asymmetric chlorinated polybutadiene-b-polystyrene, [P((CB)x-b-(PS)y)] diblock copolymers with increasing x/(x + y) ratios (up to 5.2 mol %) have been synthesized by the selective chlorination of the polybutadiene (PB) block in solution. Chlorination has been performed in anhydrous dichloromethane added with an antioxidant [2,2-methylenebis-(6-tert-butyl-4-methyl-phenol)], at -50°C, under a continuous Ar flow and in the dark. Under the optimized experimental conditions, the PB chlorination is not complete, but the PS block is left unmodified. Even in the presence of a large chlorine excess (Cl2/butene unit molar ratio of 2.5), the experimental degree of chlorination of homo PB does not exceed 85%. The chlorinated copolymers have been characterized by 1H-NMR, IR spectroscopy, size-exclusion chromatography, and elemental analysis. The chlorinated copolymers have also been studied by DSC and SAXS after annealing at 150°C. Although at this temperature the parent homopolymers are immiscible, no microphase separation has been observed for the block copolymers. [less ▲]

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See detailControlling the electrografting of polymers onto transition metal surfaces through solvent vs monomer adsorption
Crispin, Xavier; Lazzaroni, Roberto; Geskin, Victor et al

in Journal of the American Chemical Society (1999), 121(1), 167-187

Electropolymerization of methacrylic monomers opens the possibility of chemically grafting a wide range of polymers onto transition metal surfaces. In this work, the electropolymerization of ... [more ▼]

Electropolymerization of methacrylic monomers opens the possibility of chemically grafting a wide range of polymers onto transition metal surfaces. In this work, the electropolymerization of polyacrylonitrile and polyethyl acrylate is studied in different solvents; we experimentally confirm that the choice of solvent is a critical parameter for obtaining electrografted polymers. A density-functional theory−based study modeling the interaction of solvent (acetonitrile, dimethylformamide, and pyridine) or monomer (acrylonitrile and ethyl acrylate) molecules with the Ni(100) metal surface provides the means to classify the organic molecules with respect to their ability to interact with the surface. The surface binding-energy difference between monomer and solvent is introduced in a Frumkin-type isotherm. This allows us to rationalize the experimental observations in terms of a competitive adsorption at the metal surface between the monomer and the solvent. The first step in the electrografting mechanism thus appears to be the chemisorption of the monomer at the electrode surface before cathodic polarization is applied; the chemisorbed monomer is therefore the first species reduced, giving rise to an adsorbed reactive intermediate, which is thus able to start the polymerization of a grafted chain. [less ▲]

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See detailControlled radical polymerization of (meth)acrylates by ATRP with NiBr2(PPh3)2 as catalyst
Moineau, Georges; Minet, Michaël; Dubois, Philippe ULg et al

in Macromolecules (1999), 32(1), 27-35

NiBr2(PPh3)2 has been found to be an efficient catalyst for the ATRP of methyl methacrylate (MMA) and n-butyl acrylate (n-BuA) initiated by an alkyl halide in the absence of any activator (e.g., Lewis ... [more ▼]

NiBr2(PPh3)2 has been found to be an efficient catalyst for the ATRP of methyl methacrylate (MMA) and n-butyl acrylate (n-BuA) initiated by an alkyl halide in the absence of any activator (e.g., Lewis acid) at 85 °C. The molecular weight distribution of the poly(meth)acrylates is narrow (Mw/Mn = 1.1−1.4). However, some side reactions (more likely coupling reactions) are observed at high monomer conversions in the case of n-BuA. An excess of PPh3 has proved to increase the polymerization rate of MMA while preserving the control of the molecular parameters. When the catalyst/initiator molar ratio is too small (e.g., 0.05), the polymerization rate decreases, the polydispersity increases, and the initiation is less efficient. α-Acid and α-hydroxyl end groups have been successfully attached to the chains by using functional initiators, such as 2-bromo-2-methylpropionic acid and 2,2‘,2‘ ‘-tribromoethanol. Reactivity ratios for the MMA/n-BuA comonomer pair have been measured and found to be close to the values observed for a conventional free-radical polymerization. Diethyl meso-2,5-dibromoadipate has been used as a difunctional initiator for the n-BuA polymerization, leading to α,ω-bromo-poly(n-BuA) of narrow molecular weight distribution. Finally, the thermal stability of PMMA is consistent with the lack of termination reactions, while Tg is as high as 125 °C. [less ▲]

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See detailStructure-second-order polarizability relationship in chromophores incorporating a spacer: a joint experimental and theoretical study
Maertens, Christophe; Detrembleur, Christophe ULg; Dubois, Philippe ULg et al

in Chemistry : A European Journal (1999), 5(1), 369-380

A joint theoretical and experimental study is reported on the structure-polarizability relationship in a novel type of push-pull conjugated system which contains a spacer within the conjugated backbone ... [more ▼]

A joint theoretical and experimental study is reported on the structure-polarizability relationship in a novel type of push-pull conjugated system which contains a spacer within the conjugated backbone. The chromo-phores are based on a dithienyl conjugation pathway, spaced by a keto group, and selectively end-capped by a donor and an acceptor. Four chromophores were synthesized, in which the strength of the acceptor group and the length of the conjugated path were varied. The electronic properties of two model compounds were studied theoretically by means of correlated quantum-chemical calculations. The degree of ground-state polarization was varied in the calculations by the application of an external electric field and varied experimentally by the modification of the dielectric constant of a binary mixture of solvents. The linear and nonlinear optical properties of the compounds (measured in solution by hyper-Rayleigh scattering) are discussed in detail. [less ▲]

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See detailAbundance correlations in mildly metal-poor stars
Jehin, Emmanuel ULg; Magain, Pierre ULg; Neuforge, Corinne et al

in Astronomy and Astrophysics (1999), 341

Accurate relative abundances have been obtained for a sample of 21 mildly metal-poor stars from the analysis of high resolution and high signal-to-noise spectra. In order to reach the highest coherence ... [more ▼]

Accurate relative abundances have been obtained for a sample of 21 mildly metal-poor stars from the analysis of high resolution and high signal-to-noise spectra. In order to reach the highest coherence and internal precision, lines with similar dependency on the stellar atmospheric parameters were selected, and the analysis was carried out in a strictly differential way within the sample. With these accurate results, correlations between relative abundances have been searched for, with a special emphasis on the neutron capture elements. This analysis shows that the r elements are closely correlated to the alpha elements, which is in agreement with the generally accepted idea that the r-process takes place during the explosion of massive stars. The situation is more complex as far as the s elements are concerned. Their relation with the alpha elements is not linear. In a first group of stars, the relative abundance of the s elements increases only slightly with the alpha elements overabundance until the latter reaches a maximum value. For the second group, the s elements show a rather large range of enhancement and a constant (and maximum) value of the alpha elements overabundance. This peculiar behaviour leads us to distinguish between two sub-populations of metal-poor stars, namely Pop IIa (first group) and Pop IIb (second group). We suggest a scenario of formation of metal-poor stars based on two distinct phases of chemical enrichment, a first phase essentially consisting in supernova explosions of massive stars, and a second phase where the enrichment is provided by stellar winds from intermediate mass stars. More specifically, we assume that all thick disk and field halo stars were born in globular clusters, from which they escaped, either during an early disruption of the cluster (Pop IIa) or, later, through an evaporation process (Pop IIb). Based on observations obtained at the European Southern Observatory, La Silla, Chile. [less ▲]

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See detailOn the Motion of Trapped Particles in the Vicinity of Corotation Centers
Beaugé, C.; Lemaitre, Anne; Jancart, Sylvie ULg

in Celestial Mechanics and Dynamical Astronomy (1999), 73

In the present paper we analyse the motion of a massless particle during the capture process in an exterior mean-motion resonance under the effects of an external dissipative force. In particular, we ... [more ▼]

In the present paper we analyse the motion of a massless particle during the capture process in an exterior mean-motion resonance under the effects of an external dissipative force. In particular, we study the orbital evolution from its initial approach to the commensurability up to the final nesting place in the periodic orbit around the equilibrium solution. [less ▲]

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See detailRegional Distribution and Control of Tyrosine Hydroxylase Activity in the Quail Brain
Baillien, M.; Foidart, Agnès ULg; Balthazart, Jacques ULg

in Brain Research Bulletin (1999), 48(1), 3-17

Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the ... [more ▼]

Tyrosine hydroxylase (TH) activity, the rate-limiting step in the synthesis of catecholamines, was quantified in the preoptic area-hypothalamus of adult male Japanese quail by a new assay measuring the tritiated water production from 3,5-[3H]-L-tyrosine. Maximal levels of activity were observed at a 20-25 microM concentration of substrate, with more than 50% inhibition of the activity being recorded at a 100 microM concentration. TH activity was linear as a function of the incubation time during the first 20 min and maximal at a pH of 6.0. TH was heterogeneously distributed in the quail brain with highest levels of activity being found (in decreasing order) in the mesencephalon, diencephalon, and telencephalon. Given the large size of the telencephalon, this is the brain area that contains, as a whole, the highest level of enzyme activity. TH inhibitors that have been well-characterized in mammals, such as 3-iodo-L-tyrosine and L-alpha-methyl-p-tyrosine (AMPT) completely inhibited the enzyme activity at a 100 microM concentration. In mammals, the accumulation of catecholamines exerts a negative feedback control on TH activity. Similar controls were observed in the quail brain. Two inhibitors of the DOPA decarboxylase that should lead to accumulation of DOPA depressed TH activity by 60% or more, and the inhibitor of the dopamine beta-hydroxylase, fusaric acid that should cause an accumulation of dopamine, suppressed 90% of the TH activity. The addition of exogenous DOPA, dopamine, or norepinephrine to the brain homogenates also strongly inhibited TH activity, independently confirming the feedback effects of the enzyme products on the enzyme activity. These data demonstrate that TH activity in the quail brain is heterogeneously distributed and acutely regulated, as it is in mammals, by the accumulation of its products and of the derived catecholamines. [less ▲]

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See detailRecent achievements in anionic polymerization of (meth)acrylates
Jérôme, Robert ULg; Teyssié, Philippe; Vuillemin, Bruno et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1999), 37(1), 1-10

The constant progress of the anionic polymerization of (meth)acrylates is discussed from both the fundamental and practical points of view. A special attention is paid to the improved macromolecular ... [more ▼]

The constant progress of the anionic polymerization of (meth)acrylates is discussed from both the fundamental and practical points of view. A special attention is paid to the improved macromolecular engineering of (meth)acrylate-based (co)polymers. The resulting most important materials and the scaling-up process needed for their production are also emphasized. The recent developments witness for the healthy state of the anionic polymerization of these polar monomers. [less ▲]

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See detailSynthesis of well-defined poly(alkyl methacrylate)-graft-polylactone by sequential living polymerization
Mecerreyes, David; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Macromolecular Chemistry and Physics (1999), 200(1), 156-165

A novel combination of living polymerization reactions has been proposed for the controlled synthesis of poly(alkyl methacrylate)-graft-polylactones. This strategy relies upon the sequential living ... [more ▼]

A novel combination of living polymerization reactions has been proposed for the controlled synthesis of poly(alkyl methacrylate)-graft-polylactones. This strategy relies upon the sequential living polymerization of alkyl methacrylates and aliphatic lactones, with an intermediate chemical transformation for shifting from the first mechanism to the second one. In the first step, an alkyl methacrylate (methyl and butyl) is copolymerized with 2-trimethylsiloxyethyl methacrylate (TMSEMA). This living anionic polymerization is initiated with diphenylhexyllithium( DPHLi) in the presence of a μ-ligand, lithium chloride, in THF at - 78 °C. The trimethylsiloxy groups are then hydrolyzed with release of hydroxyl groups which are reacted with triethylaluminum in order to form a multifunctional macroinitiator of the Al alkoxide type. The second step consists of the ring opening polymerization (ROP) of aliphatic lactones (ε-caprolactone, J-valerolactone and 1,4,8-trioxaspiro[4.6]-9-undecanone (TOSUO)) with the formation of novel graft copolymers. As a result of the livingness of both the anionic and the ROP polymerization steps, the molecular weight of both the main backbone and the grafts is predictable, the apparent polydispersity is narrow ( from 1.05 to 1.30) and the grafting density can be controlled being dependent on the distribution of the hydroxyl groups within the precursor backbone. [less ▲]

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See detailComment j'explore ... une pneumopathie interstitielle diffuse
Bury, Thierry ULg

in Revue Médicale de Liège (1999), 54(1), 54-7

There are a large number of conditions of known or unknown causes that have a tendency to alveolar wall fibrosis. The patient usually presents with progressive dyspnoea and the chest radiograph shows ... [more ▼]

There are a large number of conditions of known or unknown causes that have a tendency to alveolar wall fibrosis. The patient usually presents with progressive dyspnoea and the chest radiograph shows bilateral shadows whereas physiological measurements show a restrictive defect. Because of implications with regard to treatment and prognosis, diagnosis and staging of the disease are important. Computed tomography ("high resolution") and bronchoalveolar lavage are very useful at all stages of management of interstitial lung disease. [less ▲]

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See detailCalculation Method for Design of Reinforced Concrete Columns under Fire Conditions
Dotreppe, Jean-Claude ULg; Franssen, Jean-Marc ULg; Vanderzeipen, Yves

in ACI Structural Journal (1999), 96(1), 9-18

This paper presents a simple model for the calculation of the fire resistance of reinforced concrete columns. It has been developed on the base of extensive numerical simulations and has been calibrated ... [more ▼]

This paper presents a simple model for the calculation of the fire resistance of reinforced concrete columns. It has been developed on the base of extensive numerical simulations and has been calibrated on the base of a large data base of full scale experimental test results [less ▲]

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See detailWhen Drug Inactivation Renders the Target Irrelevant to Antibiotic Resistance: A Case Story with Beta-Lactams
Lakaye, Bernard ULg; Dubus, Alice ULg; Lepage, Sylvie ULg et al

in Molecular Microbiology (1999), 31(1), 89-101

By challenging the efficiency of some of our most useful antimicrobial weapons, bacterial antibiotic resistance is becoming an increasingly worrying clinical problem. A good antibiotic is expected to ... [more ▼]

By challenging the efficiency of some of our most useful antimicrobial weapons, bacterial antibiotic resistance is becoming an increasingly worrying clinical problem. A good antibiotic is expected to exhibit a high affinity for its target and to reach it rapidly, while escaping chemical modification by inactivating enzymes and elimination by efflux mechanisms. A study of the behaviour of a beta-lactamase-overproducing mutant of Enterobacter cloacae in the presence of several penicillins and cephalosporins showed that the minimum inhibitory concentration (MIC) values for several compounds were practically independent of the sensitivity of the target penicillin binding protein (PBP), even for poor beta-lactamase substrates. This apparent paradox was explained by analysing the equation that relates the antibiotic concentration in the periplasm to that in the external medium. Indeed, under conditions that are encountered frequently in clinical isolates, the factor characterizing the PBP sensitivity became negligible. The conclusions can be extended to all antibiotics that are sensitive to enzymatic inactivation and efflux mechanisms and must overcome permeability barriers. It would be a grave mistake to neglect these considerations in the design of future antibacterial chemotherapeutic agents. [less ▲]

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See detailStructural and functional organization of the fengycin synthetase multienzyme system from Bacillus subtilis b213 and A1/3
Steller, S.; Vollenbroich, D.; Leenders, F. et al

in Chemistry & Biology (1999), 6(31-41),

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See detailLe défi des générations, sous la direction de J. Grand’Maison, L. Baroni et J.-M. Gauthier (compte rendu)
Fournier, Bernard ULg

in Recherches Sociographiques : Revue Pluridisciplinaire d'Etudes sur le Québec et le Canada français. (1999), XL(1)

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See detailAtheroemboles et chirurgie cardiaque: importance de la mise au point préopératoire
Kolh, Philippe ULg; Torchiana, D.; Buckley, M.

in Revue Médicale de Liège (1999), 54(1), 43-8

OBJECTIVE: Atheroembolization is a recognized complication of cardiac surgical procedures, and has been implicated in postoperative stroke, renal failure, multiorgan failure, and death. Preoperative ... [more ▼]

OBJECTIVE: Atheroembolization is a recognized complication of cardiac surgical procedures, and has been implicated in postoperative stroke, renal failure, multiorgan failure, and death. Preoperative identification of patients at risk for developing atheroemboli is essential. The aim of this study was to determine preoperative risk factors for atheroemboli and to assess the postoperative course of the patients who developed atheroembolic syndrome. METHODS: A retrospective record review was conducted. From 1/1990 to 12/1994, 5.486 patients underwent coronary artery bypass grafting (CABG), valve operations, or other cardiac surgical procedures at the Massachusetts General Hospital. Among this population, 107 patients (1.9%) developed atheroembolic syndrome. There were compared to a concurrent population of 925 patients operated during the same period. RESULTS: Patients who developed atheroemboli were older, with an increased incidence (p < 0.01) of hypertension, cerebrovascular disease, and aortoiliac disease. Many had a complicated course after catheterization, with renal insufficiency (35%) and evidence of peripheral emboli (12%). Average Intensive Care Unit stay, hospital stay, and hospital cost of these patients were 16.8 days, 48.4 days and 88,000 respectively, compared to 1.5 days, 9.6 days and 23,000 for the concurrent population. Of these 107 patients only two were discharged home, the others either died (48 patients, or 25% of all cardiac surgical deaths during this period), or rehabilitation or chronic hospital facilities. Twenty-seven autopsies were performed and invariably showed a diffusely diseased aorta, with calcification, mural thrombus, and ulceration. CONCLUSIONS: Atheroembolization during cardiac surgical procedures has profound medical and economic consequences. Because of the diffuse nature of aortic disease, measures approaching the disease as a local process are likely to be unsuccessful. Appropriate evaluation would ideally identify patients with extensive aortic atheromatous disease, prior to rather than during surgery. [less ▲]

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See detailPregnancy-associated glycoprotein and decreased polymorphonuclear leukocyte function in early post-partum dairy cows
Dosogne, H.; Burvenich, Christian; Freeman, A. E. et al

in Veterinary Immunology and Immunopathology (1999), 67(1), 47-54

Phagocytosis and oxidative burst activity of polymorphonuclear neutrophil leukocytes (PMN) isolated from blood and pregnancy-associated glycoprotein (bPAG) concentrations in plasma were evaluated in two ... [more ▼]

Phagocytosis and oxidative burst activity of polymorphonuclear neutrophil leukocytes (PMN) isolated from blood and pregnancy-associated glycoprotein (bPAG) concentrations in plasma were evaluated in two longitudinal studies in dairy cows from 3 weeks before until 5 weeks after calving, carried out in the United States and in Europe. Ingestion of Staphylococcus aureus by blood PMN increased during the first week after calving and normalised 3 weeks post-partum. Phagocytosis of Escherichia coli did not change in the early post-partum period. In both studies, a significant decrease in oxidative burst activity of PMN was observed between 1 and 3 weeks after calving. In all cows, a very significant increase in plasma bPAG concentration was found between 1 week before and 2 weeks after calving. The peak of bPAG concentration in plasma immediately preceded the alterations of blood PMN functions. These results suggest that bPAG may be associated with inhibition of PMN function of dairy cows during the early post-partum period. [less ▲]

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See detailAnalysis of Endotoxin Effects on the Intact Pulmonary Circulation
Lambermont, Bernard ULg; Kolh, Philippe ULg; Detry, Olivier ULg et al

in Cardiovascular Research (1999), 41(1), 275-81

OBJECTIVE: The mechanism of sustained alterations in pulmonary hemodynamics during endotoxin shock remains unclear. To gain more detailed knowledge we used the four-element windkessel model as a ... [more ▼]

OBJECTIVE: The mechanism of sustained alterations in pulmonary hemodynamics during endotoxin shock remains unclear. To gain more detailed knowledge we used the four-element windkessel model as a descriptor of the pulmonary circuit. METHODS: Consecutive changes in characteristic resistance (R1), vascular compliance (C), input resistance (R2) and inductance (L) were continuously assessed following injection of endotoxin in 6 anaesthetised pigs, and were compared with the corresponding values measured in a similar group of sham-operated animals. RESULTS: Endotoxin challenge resulted in a biphasic pulmonary artery pressure response. Blood flow decreased progressively from 2.8 +/- 0.2 l/min to 2 +/- 0.2 l/min. Ohmic pulmonary vascular resistance (PVR) increased gradually from 0.2 +/- 0.04 to 0.76 +/- 0.1 mm Hg s ml-1. The early increase in PAP (from 14 +/- 2 to 27 +/- 4 mm Hg) was mediated by changes in both R1 (from 0.04 +/- 0.01 to 0.06 +/- 0.01 mm Hg s ml-1) and R2 (from 0.16 +/- 0.04 to 0.61 +/- 0.2 mm Hg s ml-1). These responses, in turn, altered the proximal vascular compliance. A subsequent increase in PAP (from 27 +/- 2 to 32 +/- 3 mm Hg) paralleled the specific decline in distal pulmonary vasculature compliance from 0.84 +/- 0.1 to 0.65 +/- 0.1 ml/mmHg. Analysis of the time course of PVR did not allow us to distinguish between vasoconstriction and stiffening of the vascular tree as mechanisms accounting for PAP changes. CONCLUSIONS: Endotoxemia leads to pulmonary hypertension, which is a result of constriction of proximal pulmonary arteries during the early phase, whereas the late phase is characterised by a decline in distal pulmonary vasculature compliance. [less ▲]

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See detailPhase segregation in binary sandpiles on fractal bases
Vandewalle, Nicolas ULg; D'hulst, R.; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1999), 59(1), 631-635

We have built experimentally and have numerically studied sandpiles on a base having a prefractal perimeter. This type of perimeter induces the formation of quite complex pile shapes characterized by both ... [more ▼]

We have built experimentally and have numerically studied sandpiles on a base having a prefractal perimeter. This type of perimeter induces the formation of quite complex pile shapes characterized by both ridges and valleys. The effects of a fractal base on the phase segregation of a binary granular system have been investigated. Both demixing and self-stratification phenomena have been investigated. It is found that the demixing of binary granular piles is enhanced by the prefractal perimeter character. The concentration profiles are given. This is briefly discussed in terms of length scale selection. [less ▲]

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See detailRuth & Elihu Katz, D'où venait-il, où a-t-il disparu ?
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailSuccessful Treatment of Pulmonary Lymphangioleiomyomatosis with Progestins: A Case Report
Denoo, Xavier ULg; Hermans, Gilberte ULg; Degives, R. et al

in CHEST (1999), 115(1), 276-9

The diagnostic approach, clinical evolution, and treatment of a patient with primary pulmonary lymphangioleiomyomatosis are reported. This patient presented a restrictive respiratory syndrome resistant to ... [more ▼]

The diagnostic approach, clinical evolution, and treatment of a patient with primary pulmonary lymphangioleiomyomatosis are reported. This patient presented a restrictive respiratory syndrome resistant to conventional glucocorticoid therapy. The diagnosis, based on clinical and histologic examinations, was confirmed by immunohistochemical localization of one of the desmins, the smooth muscle cell actin, and HMB45 antigen. The patient received treatment with an anti-estrogenic agent (tamoxifen citrate) and high doses of medroxyprogesterone acetate, an antigonadotropic progestin. Respiratory function improved rapidly with clinical relief. [less ▲]

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See detailCardiovascular Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade, by Metrenperone, in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Veterinary Journal (1999), 157(1), 31-37

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and ... [more ▼]

The cardiovascular response to 5-hydroxytryptamine (5-HT) challenge has been previously described in cattle. Abrupt bradycardia, followed by tachycardia, triphasic systemic blood pressure response, and pulmonary hypertension were the major changes elicited by 5-HT. The purpose of the present study was to determine whether the cardiovascular response to 5-HT in calves was attributable to 5-HT2 receptors. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg) was administered intramuscular to six unsedated Friesian calves 30 min before the animals were given a 5-min intravenous 5-HT infusion. Mean systemic arterial (SAP), mean pulmonary arterial (PAP), pulmonary capillary wedge (PW) pressures were obtained by means of fluid-filled catheters, and cardiac output (CO) was measured by the thermodilution technique. Heart rate, stroke volume, systemic (SVR) and pulmonary (PVR) vascular resistances were calculated. Administration of 5-HT after metrenperone induced a short-lasting period of severe bradycardia followed by tachycardia and increased CO. The systemic blood pressure response was exclusively hypotensive and associated with a decrease in SVR. Conversely, PAP, PW, and PVR were not modified by 5-HT administration. The results establish that 5-HT induced systemic as well as pulmonary hypertension is mediated through the activation of type-2 serotonergic or alpha-adrenergic receptors, or both. In contrast, neither apnoea, bradycardia and hypotension, nor the positive chronotropic effect induced by 5-HT in cattle are mediated through such receptors. [less ▲]

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See detailLes tumeurs malignes d'origine indéterminée
Rezaei Kalantari, Hassan ULg; Jerusalem, Guy ULg; Bours, Vincent ULg et al

in Revue Médicale de Liège (1999), 54(1), 39-42

Cancers of unknown origin form a specific clinical entity. The diagnostic procedure has to be guided by the therapeutical possibilities and requires a biopsy. Immunohistology, electron microscopy and ... [more ▼]

Cancers of unknown origin form a specific clinical entity. The diagnostic procedure has to be guided by the therapeutical possibilities and requires a biopsy. Immunohistology, electron microscopy and cytogenetics are informative for carcinomas and poorly differentiated adenocarcinomas. The clinical status and the histology allow the definition of groups of patients who can benefit from a specific therapy and have a better prognosis. For the other patients, the prognosis is severe and there is no efficient therapy available. Such tumors are usually characterized by a very aggressive behaviour. [less ▲]

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See detailL'image du mois. Kyste hydatique hépatique
Radermecker, Régis ULg; Nkoghe, D.; Labasse, J. M. et al

in Revue Médicale de Liège (1999), 54(1), 4-5

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See detailRegional brain activity during tasks devoted to the central executive of working memory
Collette, Fabienne ULg; Salmon, Eric ULg; Van der Linden, Martial ULg et al

in Cognitive Brain Research (1999), 7(3), 411-417

Most previous PET studies investigating the central executive (CE) component of working memory found activation in the prefrontal cortex. However, the tasks used did not always permit to distinguish ... [more ▼]

Most previous PET studies investigating the central executive (CE) component of working memory found activation in the prefrontal cortex. However, the tasks used did not always permit to distinguish precisely the functions of the CE from the storage function of the slave systems. The aim of the present study was to isolate brain areas that subserve manipulation of information by the CE when the influence of storage function was removed. A PET activation study was performed with four cognitive tasks, crossing conditions of temporary storage and manipulation of information. The manipulation of information induced an activation in the right (BA 10/46) and left (BA 9/6) middle frontal gyrus and in the left parietal area (BA7). The interaction between the storage and manipulation conditions did not reveal any significant changes in activation. These results are in agreement with the hypothesis that CE functions are distributed between anterior and posterior brain areas, but could also reflect a simultaneous involvement of controlled (frontal) and automatic (parietal) attentional systems. In the other hand, the absence of interaction between the storage and manipulation conditions demonstrates that the CE is not necessarily related to the presence of a memory load. [less ▲]

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See detailCardiac Troponin I and Troponin T: Recent Players in the Field of Myocardial Markers
Chapelle, Jean-Paul ULg

in Clinical Chemistry & Laboratory Medicine (1999), 37(1), 11-20

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the ... [more ▼]

The troponin (Tn) complex consists of three subunits referred to as TnT, TnI and TnC. Myocardium contains TnT and TnI isoforms which are not present in skeletal muscles and which can be separated from the muscular isoforms by immunological techniques. Using commercially available immunoassays, clinical laboratories are able to determine cardiac TnT and TnI (cTnT and cTnI) quickly and reliably as classical cardiac markers. After acute myocardial infarction, cTnT and cTnI concentrations start to increase in serum in a rather similar way than CK-MB, but return to normal after longer periods of time (approximately one week). Because of their excellent cardiac specificity, Tn subunits appear ideally suited for the differential diagnosis of myocardial and muscular damage, for example in noncardiac surgery patients, in patients with muscular trauma or with chronic muscular diseases, or after intense physical exercise. cTnT and cTnI may also be used for detecting evidence of minor myocardial damage: therefore they have found new clinical applications, in particular risk stratification in patients with unstable angina. In spite of the possible reexpression of cTnT in human skeletal muscles, and of the lack of standardization of cTnI assays, Tn subunits are not far to meet the criteria of ideal markers for acute myocardial injury. Only an insufficient sensitivity in the first hours following the acute coronary syndroms requiries to maintain an early myocardial marker in the cardiac panel for routine laboratory testing. [less ▲]

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See detailWhole-Body 18f-Fdg Pet for the Evaluation of Patients with Hodgkin's Disease and Non-Hodgkin's Lymphoma
Jerusalem, Guy ULg; Warland, V.; Najjar, F. et al

in Nuclear Medicine Communications (1999), 20(1), 13-20

Whole-body metabolic information provided by 18F-FDG PET could help in the evaluation of lymphoma patients at diagnosis and follow-up. We studied 60 patients, 42 at initial presentation and 18 for disease ... [more ▼]

Whole-body metabolic information provided by 18F-FDG PET could help in the evaluation of lymphoma patients at diagnosis and follow-up. We studied 60 patients, 42 at initial presentation and 18 for disease recurrence (23 aggressive non-Hodgkin's lymphoma, 21 low-grade non-Hodgkin's lymphoma and 16 Hodgkin's disease). All patients underwent a clinical examination, computed tomography (CT) and a non-attenuated PET scan within 1 week. The patients received 222-296 MBq (6-8 mCi) 18F-FDG intravenously and emission scans were recorded 45-90 min later. 18F-FDG PET detected more lymph nodes than the clinical examination or CT, but this rarely resulted in upstaging (two patients). The concordance between PET and CT for the evaluation of the spleen, liver and digestive tract was quite good. Discordance was noted in 12 patients for the evaluation of bone marrow infiltration, but confirmation by MRI or focal biopsy was not always obtained. We conclude that non-attenuated 18F-FDG PET is an easy and efficient whole-body method for the evaluation of patients with lymphomas. Compared with conventional techniques, however, it does not appear to offer much improvement for staging but provides a satisfactory base for follow-up. [less ▲]

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See detailL'Horreur adolescente
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (1999), 4

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See detailJojo, Ludo, Toto et les autres
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (1999), 4

A small overview of some comics for children published at the end of the nineties.

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See detailMorphometrical study of the equine navicular bone: age-related changes and influence of exercise
Gabriel, Annick ULg; Detilleux, Johann ULg; Jolly, Sandra ULg et al

in Veterinary Research Communications (1999), 23(1), 15-40

Navicular bones from the four limbs of 95 horses, classified in 9 categories, were studied. The effects of age on navicular bone morphometry and histomorphometry were estimated, after adjustment of the ... [more ▼]

Navicular bones from the four limbs of 95 horses, classified in 9 categories, were studied. The effects of age on navicular bone morphometry and histomorphometry were estimated, after adjustment of the data to even out the effects of front and rear limbs, morphometrical type, sex, weight, and size. All the external measurements of the navicular bone decreased significantly with increasing age. From the histomorphometrical data, cortical bone volume decreased with age in most horses, whereas cancellous bone volume and, in particular, the marrow spaces increased. The increase in the cancellous bone volume could have resulted from tunnelling of the internal part of the cortex, which converted it progressively into a porous trabecular-like structure. Trabecular bone volume also decreased with age and the trabecular lattice changed dramatically to become disconnected in aged horses. These observations corresponded closely to those reported for ageing of the skeletal system in humans. However, in sporting horses, the navicular cortical bone volume increased with age and the cancellous bone volume decreased. Exercise appeared to have decreased bone resorption and increased bone formation at the endocortical junction. The cancellous bone architecture was also improved. in that the trabecular lattice and trabecular bone volume remained unchanged in aged sporting horses. Our findings confirmed that exercise may be good practice to prevent age-related bone loss. [less ▲]

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See detailJames W. Carey, McLuhan : généalogie et descendance d'un paradigme
Durand, Pascal ULg

in Quaderni : la Revue de la Communication (1999), 37

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See detailPreliminary classification of the bovine respiratory complex into different levels of severity
Coghe, Joost; Uystepruyst, Christophe; Bureau, Fabrice ULg et al

in Bovine Practitioner (1999), 33(1), 85-87

Despite prophylactic measures, mainly including vaccination programs and management measures, respiratory disease remains the major cause of economic losses in the bovine species. Choice of treatment is ... [more ▼]

Despite prophylactic measures, mainly including vaccination programs and management measures, respiratory disease remains the major cause of economic losses in the bovine species. Choice of treatment is currently mainly based on the clinicians' personal experience. A theoretical method has been proposed earlier to classify this syndrome into four grades of severity : Grade 1, subclinical disease (no treatment); Grade 2, compensated clinical disease (antibiotics only); Grade 3, noncompensated clinical disease (antibiotics + anti inflammatory drugs); and Grade 4, irreversible clinical disease (no treatment). In order to realize this theoretical classification under field conditions, three techniques, each one evaluating the oxygen transport chain at a différent level, have been studied and validated, i.e. pulse oximetry, lactate dosage and the lobeline test. Afterwards, measurements were performed on calves suffering from acute respiratory disease and a preliminary classification was established. This novel approach could orientate and economize therapeutic strategies in bovine respiratory disease. [less ▲]

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See detailTroubles psychiatriques et dangerosité
Papart, Patrick ULg

in Acta Psychiatrica Belgica (1999), 99

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See detailCytokinin modulates catalase activity and coumarin accumulation in in vitro cultures of tobacco
Petit-Paly, Geneviève; Franck, Thierry ULg; Brisson, Louise et al

in Journal of Plant Physiology (1999), 155(1), 9-15

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present ... [more ▼]

Cytokinins (CKs) represent an important class of phytohormones particularly known for their antisenescence properties that might be regulated through an effect on the oxidative metabolism. In the present work, we demonstrate the effect of CKs on catalase activity in tobacco cultivated in vitro. The catalase activity observed in suspension-cultured cells decreased slightly during the first hour of CK treatment and increased thereafter to double the level detected in untreated cells. In contrast to these results, catalase activity was inhibited in shoot cultures in which the endogenous levels of CK were elevated by the introduction of the isopentenyltransferase gene or by an exogenous feeding of CK to the cultures. Interestingly, this catalase inhibition correlated with an accumulation of scopolin, an inducible coumarin. Taken together, our results show that CK modulates (directly or undirectly) catalase activity. The inverse relationship that was always found between scopolin accumulation and catalase activity is discussed in terms of vitrification and habituation. [less ▲]

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See detailCompte rendu de J. VERGER, La renaissance du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1999)

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See detailS/SL/PPV : le prix de l'information du futur
Jérôme, Simone

in Cahiers de la Documentation = Bladen voor Documentatie (1999), (1), 3-25

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See detailCardiac autonomic dysfunction in diabetic children.
Massin, M. M.; Derkenne, B.; Tallsund, M. et al

in Diabetes care (1999), 22(11), 1845-50

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can ... [more ▼]

OBJECTIVE: Adults with type 1 diabetes may have abnormal alterations in heart rate variability (HRV) due to cardiac autonomic neuropathy. This prospective study was performed to determine whether HRV can be used to detect subclinical autonomic neuropathy in diabetic children. RESEARCH DESIGN AND METHODS: We examined five time domain and three frequency domain HRV indices determined from 24-h Holter recordings in 73 diabetic children and adolescents aged 3-18 years (mean 12.1 years) with a mean duration of diabetes of 55 months. The measures were compared with normal ranges. Z scores were established for each parameter and were compared with classic risk factors of other diabetic complications. RESULTS: Most HRV indices were significantly depressed in children aged > or = 11 years, and the levels of HRV abnormalities were significantly correlated with long-term metabolic control (mean GHb for 4 years) in that age-group. In younger patients, HRV indices were within the normal range and were not correlated with the level of metabolic control. Illness duration and microalbuminuria but not short-term metabolic control (most recent GHb) were also independently predictive of HRV abnormalities. CONCLUSIONS: These results suggest that early puberty is a critical period for the development of diabetic cardiac autonomic dysfunction. Therefore, all type 1 diabetic patients should be screened for this complication by HRV analysis beginning at the first stage of puberty regardless of illness duration, microalbuminuria, and level of metabolic control. [less ▲]

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See detailSymbolic Verification of Communication Protocols with Infinite State Spaces using QDDs
Boigelot, Bernard ULg; Godefroid, Patrice

in Formal Methods in System Design (1999), 14(3), 237-255

We study the verification of properties of communication protocols modeled by a finite set of finite-state machines that communicate by exchanging messages via unbounded FIFO queues. It is well-known that ... [more ▼]

We study the verification of properties of communication protocols modeled by a finite set of finite-state machines that communicate by exchanging messages via unbounded FIFO queues. It is well-known that most interesting verification problems, such as deadlock detection, are undecidable for this class of systems. However, in practice, these verification problems may very well turn out to be decidable for a subclass containing most "real" protocols. Motivated by this optimistic (and, we claim, realistic) observation, we present an algorithm that may construct a finite and exact representation of the state space of a communication protocol, even if this state space is infinite. Our algorithm performs a loop-first search in the state space of the protocol being analyzed. A loop-first search is a search technique that attempts to explore first the results of successive executions of loops in the protocol description (code). A new data structure named Queue-content Decision Diagram (QDD) is introduced for representing (possibly infinite) sets of queue-contents. Operations for manipulating QDDs during a loop-first search are presented. A loop-first search using QDDs has been implemented, and experiments on several communication protocols with infinite state spaces have been performed. For these examples, our tool completed its search, and produced a finite symbolic representation for these infinite state spaces. [less ▲]

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See detailA scintigraphic study of post-massage blood flow in human lower limb
Vanderthommen, Marc ULg; Depresseux, J.C.; Dauchat, L. et al

in European Journal of Physical Medicine & Rehabilitation (1999), 8(6), 159-162

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See detail7-Iodo-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; De Tullio, Pascal ULg

in Acta Crystallographica (1999), C55

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See detailUDP-N-Acetyl-alpha-D-glucosamine as acceptor substrate of beta-1,4-galactosyltransferase. Enzymatic synthesis of UDP-N-acetyllactosamine.
Elling, Lothar; Zervosen, Astrid ULg; Gallego, Ricardo Gallego et al

in Glycoconjugate Journal (1999), 16(7), 327-36

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant ... [more ▼]

The capacity of UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) as an in vitro acceptor substrate for beta-1,4-galactosyltransferase (beta4GalT1, EC 2.4.1.38) from human and bovine milk and for recombinant human beta4GalT1, expressed in Saccharomyces cerevisiae, was evaluated. It turned out that each of the enzymes is capable to transfer Gal from UDP-alpha-D-galactose (UDP-Gal) to UDP-GlcNAc, affording Gal(beta1-4)GlcNAc(alpha1-UDP (UDP-LacNAc). Using beta4GalT1 from human milk, a preparative enzymatic synthesis of UDP-LacNAc was carried out, and the product was characterized by fast-atom bombardment mass spectrometry and 1H and 13C NMR spectroscopy. Studies with all three beta4GalTs in the presence of alpha-lactalbumin showed that the UDP-LacNAc synthesis is inhibited and that UDP-alpha-D-glucose is not an acceptor substrate. This is the first reported synthesis of a nucleotide-activated disaccharide, employing a Leloir glycosyltransferase with a nucleotide-activated monosaccharide as acceptor substrate. Interestingly, in these studies beta4GalT1 accepts an alpha-glycosidated GlcNAc derivative. The results imply that beta4GalT1 may be responsible for the biosynthesis of UDP-LacNAc, previously isolated from human milk. [less ▲]

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See detailNondispersive two-electron wave packets in the collinear driven helium atom
Schlagheck, Peter ULg; Buchleitner, A.

in Europhysics Letters [=EPL] (1999), 46(1), 24-30

Nondispersive two-electron wave packets are found in the Floquet spectrum of the driven, one-dimensional helium atom. In classical phase space, they are anchored to the principal nonlinear resonance ... [more ▼]

Nondispersive two-electron wave packets are found in the Floquet spectrum of the driven, one-dimensional helium atom. In classical phase space, they are anchored to the principal nonlinear resonance between the collinear frozen planet orbit and the driving field linearly polarized along the orbit. These novel, highly correlated eigenstates of the driven three-body Coulomb problem, exhibit lifetimes of the order of 10(3)...10(7) periods of the driving field, with strong fluctuations reminiscent of chaos-assisted tunneling. [less ▲]

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See detailHypnoanesthesia for endocrine cervical surgery: a statement of practice.
Defechereux, Thierry ULg; Meurisse, Michel ULg; Hamoir, Etienne ULg et al

in Journal of Alternative & Complementary Medicine : Research on Paradigm, Practice, & Policy (1999), 5(6), 509-20

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and ... [more ▼]

OBJECTIVES: To assess the feasibility of endocrine cervical surgery under hypnoanesthesia as a valuable, safe, efficient, and economic alternative to general anesthesia. METHODS: Between April 1994 and June 1997, 197 thyroidectomies and 21 cervical explorations for hyperparathyroidism were performed under hypnoanesthesia (HYP) using Erikson's method. Operative data and postoperative course of this initial series were compared to a contemporary population of patients (n = 119) clinically similar except that they declined HYP or were judged unsuitable for it, and who were therefore operated on under general anesthesia (GA). RESULTS: The surgeons all reported better operating conditions for cervicotomy using HYP. Conversion from hypnosis to GA was needed in two cases (1%). All patients having HYP reported a pleasant experience and, keeping in mind that the GA group is not a randomly assigned control group, both had significantly less postoperative pain and analgesic use. Hospital stay was also significantly shorter, providing a substantial reduction in the costs of medical care. The postoperative convalescence was significantly improved after HYP and a full return to social or professional activity was significantly quicker. CONCLUSION: From this study, we conclude that HYP is an effective technique for providing relief of intraoperative and postoperative pain in endocrine cervical surgery. The technique results in high patient satisfaction and better surgical convalescence. This technique can therefore be used in most well-chosen patients and reduces the socioeconomic impact of hospitalization. [less ▲]

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See detailMigrants and Ethnic Minorities in Europe: Scapegoats or social Actors ? - D. Joly
Martiniello, Marco ULg

in Ethnic and Racial Studies (1999), 22(5), 909-910

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See detailCrystallization and preliminary X-ray analysis of a new L-aminopeptidase-D-amidase/D-esterase activated by a Gly-Ser peptide bond hydrolysis.
Bompard-Gilles, C; Villeret, V; Fanuel, L et al

in Acta Crystallographica Section D-Biological Crystallography (1999), 55(Pt 3), 699-701

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group ... [more ▼]

Ochrobactrum anthropi possesses an L-aminopeptidase (DmpA) also able to act as a D-amidase/D-esterase. DmpA (40 kDa) is activated by auto-catalyzed protein splicing liberating an alpha-amino group presumably used as a general base in the catalytic mechanism. Two crystal forms were obtained at 294 K in 13-16% PEG 2000 mono-methylether at pH 9.0, adding either 0.2 M magnesium chloride or 1 M lithium chloride. Crystals of the first form belong to the space group C2221 and diffract to 3.0 A resolution, whereas crystals of the second form belong to the space group P21212 and diffract to 2.3 A resolution. Initial screening for heavy-atom derivatives on form II crystals, has led to a well substituted Hg derivative. [less ▲]

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See detailAnesthesie generale versus anesthesie perimedullaire.
Murayi, P.; Joris, Jean ULg; Lamy, Maurice ULg

in Revue Médicale de Liège (1999), 54(7), 588-92

Perimedullary anesthetic techniques (epidural or spinal anesthesia), by themselves or combined with general anesthesia offer several advantages in the postoperative period when compared with general ... [more ▼]

Perimedullary anesthetic techniques (epidural or spinal anesthesia), by themselves or combined with general anesthesia offer several advantages in the postoperative period when compared with general anesthesia alone. The incidence of postoperative respiratory and cardiovascular complications is decreased. The physiologic stress reaction, with its associated hypercoagulable state and immune depression, is attenuated. Finally, the resumption of gastrointestinal function is hastened. These benefits of central neural blockade are noted most clearly when the techniques are used for several days postoperatively, most often by catheter based epidural analgesia. The use of local anesthetic agents in the analgesic mixture would appear to be important. This is likely because these substances inhibit the sympathetic nervous system and spinal reflex axes. The role of this inhibition in the advantages of perimedullary techniques is probably important. It is important to note that inhibition of the sympathatetic nervous system can be associated with indesirable consequences in certain patients. These techniques must therefore be used cautiously, and patients who benefit from them must receive careful surveillance. [less ▲]

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See detailRadio-oncologie et radiothérapie. Confirmation de l'efficacité des radiations ionisantes en oncologie, et renouveau de leur intérêt dans les affections non oncologiques : Acquisitions thérapeutiques 1998
OZSAHIN; MIRIMANOFF; PICA, A et al

in Médecine et Hygiène (1999), 54(2238), 100-111

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer ... [more ▼]

En 1998, plusieurs études ont clarifié ou confirmé l'effet positif de la radiothérapie dans le cancer du sein in situ, dans différents types de lymphomes non hodgkinien et hodgkinien, et dans le cancer bronchique à petites cellules. Deux métaanalyses par contre semblent remettre en cause la radiothérapie, dans la maladie de Hodgkin de stade avancé et dans l'approche postopératoire du cancer ronchique à non petites cellules. Ces méta-analyses comportent toutefois d'importantes faiblesses et doivent être interprétées de façon critique. Dans le domaine technique de la radio-oncologie, les progrès spectaculaires de la planification assistée par ordinateur et l'intégration de l'imagerie IRM peuvent maintenant s'appliquer aussi à la curiethérapie. Enfin, la radiothéraple dans les affections non oncologiques suscite un nouvel intérêt, comme par exemple la curiethérapie intracoronarienne, un traitement prometteur pour prévenir la resténose coronarienne. [less ▲]

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See detailNegative magnetoresistance in mixed-valence La0.6Y0.1Ca0.3MnO3: Evidence for charge localization governed by the Curie-Weiss law
Sergeenkov, S.; Bougrine, Hassan ULg; Ausloos, Marcel ULg et al

in JETP Letters (1999), 70(2), 141-146

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss ... [more ▼]

The colossal negative magnetoresistance Delta rho observed in La0.6Y0.1Ca0.3MnO3 at B=1 T shows an unusual, nearly perfect symmetry (around the peak temperature T-0=160 K), suggestive of a Curie-Weiss-dominated transport mechanism in this material both above and below the field-dependent Curie temperature T(C)equivalent to T-0. Attributing this symmetry to strong magnetic fluctuations below T-C (which are triggered by the Y substitution and cause a "bootstrap" destruction of the ferromagnetic phase), the data are interpreted in terms of the nonthermal spin hopping and magnetization-dependent charge carrier localization scenario leading to Delta rho=-rho(s)(1-e(-gamma M2)), with the magnetization M(T,B)=CB/\ T-T-C(B)\(nu). The separate fits through all the data points above and below T-C yield C(+)similar or equal to 2C(-) and nu(+)similar or equal to nu(-)similar or equal to 1, in agreement with the predictions of the Landau mean-field theory. (C) 1999 American Institute of Physics. [S0021-3640(99)01314-6]. [less ▲]

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See detailGenes for rare idiopathic generalized epilepsies: BFNC.
Singh, N.; Charlier, Carole ULg; Peiffer, A. et al

in Advances in neurology (1999), 79

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See detailDual Harmonic and Time Approaches for the Design of Microwave Devices
Meys, B.; Geuzaine, Christophe ULg; Henrotte, F. et al

in IEEE Transactions on Magnetics (1999), 35(3), 1829--1832

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See detailOncologie gastro-intestinale
Coucke, Philippe ULg; FREI; FELLEY et al

in Médecine et Hygiène (1999), 57(2240), 213-217

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant ... [more ▼]

Même si aucune acquisition nouvelle n'est venue embaumer l'atmosphère encore trop souvent grisâtre de l'oncologie gastro-intestinale en 1998, la nécessité d'un consilium préthérapeutique associant chirurgiens, endoscopeurs, oncologues et radio-oncologues s'impose avec encore plus de fermeté, pour tous les cancers digestifs. Les patients devraient autant que possible être inclus dans des protocoles d'études bien conduits et bénéficier d'une chirurgie oncologique optimale. [less ▲]

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See detailInfluence function and efficiency of the minimum covariance determinant scatter matrix estimator
Croux, C.; Haesbroeck, Gentiane ULg

in Journal of Multivariate Analysis (1999), 71(2), 161-190

The minimum covariance determinant (MCD) scatter estimator is a highly robust estimator for the dispersion matrix of a multivariate, elliptically symmetric distribution. It is relatively fast to compute ... [more ▼]

The minimum covariance determinant (MCD) scatter estimator is a highly robust estimator for the dispersion matrix of a multivariate, elliptically symmetric distribution. It is relatively fast to compute and intuitively appealing. In this note we derive its influence function and compute the asymptotic variances of its elements. A comparison with the one step reweighted MCD and with S-estimators is made. Also finite-sample results are reported. (C) 1999 Academic Press AMS 1991 subject classifications: 62F35, 62G35. [less ▲]

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See detailStudy of the mechanism of direct laser desorption/ionisation for some small organic molecules (M < 400 daltons)
Benazouz, M.; Hakim, B.; Debrun, J. L. et al

in Rapid Communications in Mass Spectrometry : RCM (1999), 13(23), 2302-2304

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates ... [more ▼]

Aspects of direct laser desorption/ionisation have been studied for three molecules, aminotriazole (positive ion), dinoterb and ioxynil (negative ion). The samples are deposited on metallic substrates, and a nitrogen laser is used for desorption/ionisation; ion yields are measured with a time-of-flight mass spectrometer, Previous work had shown that ion yields can strongly vary from one substrate to another, and that this variation does not reflect the (calculated) metal surface temperatures. New results obtained in this work indicate that the desorption/ionisation mechanism is linked to the physical state of the substrate surface. Copyright (C) 1999 John Wiley & Sons, Ltd. [less ▲]

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See detailImmunohistochemical study of the proliferation index, oestrogen receptors and progesterone receptors A and B in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist therapy
NISOLLE, Michelle ULg; Gillerot, Stéphane; Casanas-Roux, Françoise et al

in Human Reproduction (1999), 14(11), 2844-2850

The cell proliferation-associated antigen Ki 67 and the immunohistochemical content of oestrogen receptors (ER), progesterone receptors AB (PRAB) and progesterone receptors B (PRB) were evaluated in ... [more ▼]

The cell proliferation-associated antigen Ki 67 and the immunohistochemical content of oestrogen receptors (ER), progesterone receptors AB (PRAB) and progesterone receptors B (PRB) were evaluated in leiomyomata and adjacent myometrium during the menstrual cycle and in leiomyomata under gonadotrophin-releasing hormone agonist (GnRHa) therapy. The proliferative status of muscular cells was measured by evaluating the percentage of nuclei staining positive for Ki 67 (proliferation index). Quantitative analysis (QH-score) was carried out using advanced stereographic computer technology to investigate ER, PRAB and PRB. Leiomyoma and myometrial biopsies were taken from 30 patients undergoing hysterectomy or myomectomy because of symptomatic leiomyomata (subgroup I). Leiomyoma biopsies were taken from 10 patients suffering from symptomatic submucosal leiomyomata, after 2 month GnRH therapy (subgroup II). During the secretory phase, the proliferation index (Ki 67) was found to be higher in leiomyomata than in myometrium, but the difference was not significant. Oestrogen receptor content was significantly higher in leiomyomata than in myometrium only during the proliferative phase of the cycle. PRAB and PRB content were found to be higher in leiomyomata than in adjacent myometrium with a statistically significant dominance of PRAB over PRB. Under GnRHa therapy, a dramatic decrease was observed in PRAB and B content as well as Ki 67 but ER content remained comparable with the results obtained during the menstrual cycle. The results suggest that leiomyomata may be under the influence of progesterone which may play a major role in their growth. [less ▲]

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See detailA critical compilation and extended analysis of the Ne IV spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete ... [more ▼]

Since Moore published her well-known tables of atomic and ionic energy levels (in 1949-1951), the number of observed lines of the light atoms and their ions has grown signifi cantly. The lack of complete and consistent up-to-date tables of spectral lines and energy levels, particularly of the neon-ions spectra, notably reduces possibilities of interpretation of astrophysical and laboratory spectra. In the present paper, all optical spectral lines of Ne IV observed in 24 previous works have been systematised together with recent observations made by means of the beam-foil method at Liège University. As a result of our extended analysis of the whole set of available data, 35 new energy levels have been found and 90 newly classi ed spectral lines have been listed for the Ne IV spectrum, only a few of them having been reported previously. A complete table of observed and classi ed spectral lines has been built, and the list of optimised energy levels has been derived from it in a consistent way. A new, improved, ionisation potential of Ne IV has been deduced from the experimental data. [less ▲]

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See detailImmunohistochemical study of the rectus sheath and transversalis facia in adult groin hernias
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1999), 3

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See detailA critical compilation and extended analysis of the Ne V spectrum
Kramida, A. E.; Bastin, Thierry ULg; Biémont, Emile ULg et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (1999), 7

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the ... [more ▼]

Previous works devoted to the Ne V spectrum are very fragmentary and yield a rather controversial picture of this ion. A lot of unidentifi ed lines are still reported in these multiple studies. In the present paper, Hartree-Fock calculations and least-squares fi ts over the whole set of the available data (including the most recent ones) have been performed. As a result, a comprehensive view of the Ne V spectrum is presented. 10 new energy levels and 40 newly classi fied lines are proposed. An improved value of the ionisation potential of Ne V is also proposed. [less ▲]

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See detailTreatment of Inflammatory Bowel Disease with Azathioprine: How to Use It in 1999
Louis, Edouard ULg; Belaiche, Jacques ULg

in Acta Gastro-Enterologica Belgica (1999), 62(4, Oct-Dec), 437-9

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their ... [more ▼]

Azathioprine and 6-mercaptopurine are effective drugs in the management of steroid dependent and chronic active inflammatory bowel diseases. They are also well tolerated on the long term. However, their use is still hampered by some drawbacks including delay before efficacy, 20-35% of non responders, relapse at withdrawal of the drugs, possible bone marrow toxicity and other side effects. During the last few years, these drawbacks have been challenged by important studies showing that a better knowledge of the metabolism of these drugs may help to improve their use. [less ▲]

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See detailFrom Neural Stem Cells to Myelinating Oligodendrocytes
Rogister, Bernard ULg; Ben Hur, Tamir; Dubois-Dalcq, Monique

in Molecular & Cellular Neuroscience [=MCN] (1999), 14

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See detailLa découverte d'or natif dans le quartzite devellien de Hourt autorise un autre regard sur le site de Rompt-le-Cou
Hanson, Alain ULg; Dehove, J.; Debbaut, Vincent ULg et al

in Glain et Salm. Haute Ardenne (1999), 51

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See detailCerebral metabolism during vegetative state and after recovery to consciousness
Laureys, Steven ULg; Lemaire, Christian ULg; Maquet, Pierre ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (1999), 67(1), 121-122

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See detailQuantitative palynology of Famennian events in the Ardenne-Rhine Regions.
Streel, Maurice ULg

in Abhandlungen der Geologischen Bundesanstalt (1999), 54

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See detailThe Structural And Functional Organization Of H-Ns-Like Proteins Is Evolutionarily Conserved In Gram-Negative Bacteria
Bertin, P.; Benhabiles, N.; Krin, E. et al

in Molecular Microbiology (1999), 31(1), 319-29

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi ... [more ▼]

The structural gene of the H-NS protein, a global regulator of bacterial metabolism, has been identified in the group of enterobacteria as well as in closely related bacteria, such as Erwinia chrysanthemi and Haemophilus influenzae. Isolated outside these groups, the BpH3 protein of Bordetella pertussis exhibits a low amino acid conservation with H-NS, particularly in the N-terminal domain. To obtain information on the structure, function and/or evolution of H-NS, we searched for other H-NS-related proteins in the latest databases. We found that HvrA, a trans-activator protein in Rhodobacter capsulatus, has a low but significant similarity with H-NS and H-NS-like proteins. This Gram-negative bacterium is phylogenetically distant from Escherichia coli. Using theoretical analysis (e.g. secondary structure prediction and DNA binding domain modelling) of the amino acid sequence of H-NS, StpA (an H-NS-like protein in E. coli), BpH3 and HvrA and by in vivo and in vitro experiments (e.g. complementation of various H-NS-related phenotypes and competitive gel shift assay), we present evidence that these proteins belong to the same class of DNA binding proteins. In silico analysis suggests that this family also includes SPB in R. sphaeroides, XrvA in Xanthomonas oryzae and VicH in Vibrio cholerae. These results demonstrate that proteins structurally and functionally related to H-NS are widespread in Gram-negative bacteria. [less ▲]

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See detailInter-laboratory comparison of cytogenetic endpoints for the biomonitoring of radiological workers.
Thierens, H.; Vral, A.; de Ridder, L. et al

in International Journal of Radiation Biology (1999), 75(1), 23-34

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples ... [more ▼]

PURPOSE: The evaluation of different cytogenetic endpoints of radiation damage for the biomonitoring of contract workers temporarily employed at nuclear power plants. MATERIALS AND METHODS: Blood samples from six donors were irradiated in vitro with doses ranging from 0.1 to 2Gy 60Co gamma-rays. Compared were a conventional analysis for dicentrics, the conventional micronucleus (MN) assay, the centromere micronucleus assay using p82H and an alphaAllCen pancentromeric probe, and tricolour FISH with chromosome 2, 4 and 8 DNA probes for the scoring of translocations. RESULTS: Agreement in the number of MN between Giemsa-and propidium iodine fluorescence-stained preparations was obtained. The control samples showed higher centromere positivity for the MN after FISH with the p82H probe compared with the alphaAllCen probe. The MN results with both probes showed a slight but systematic increase in the number of centromere-positive MN with dose, indicating that radiation, although principally clastogenic, also has aneuploidogenic properties. The values of the genomic translocation frequency (FG) derived from the observed translocation frequencies were systematically higher than the dicentric yields. Comparing the sensitivity of the different methods with restriction of the scoring time to 1 day for biomonitoring purposes, the centromere micronucleus assay had the lowest dose detection limit (0.1 to 0.2 Gy). CONCLUSION: This study shows that at present only the centromere micronucleus assay can combine high sensitivity with a reasonable scoring time for the biomonitoring of relatively large populations. [less ▲]

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See detailSur philellên chez Cicéron
Rochette, Bruno ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1999), 68

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See detailMaladie de Crohn. Récidives post-opératoires. Conduite à tenir.
Belaiche, Jacques ULg; Louis, Edouard ULg

in Acta Endoscopica (1999), 29

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See detailOptimal acquisition of video images in reflected light microscopy
Pirard, Eric ULg; Lebrun, Vincent; Nivart, Jean-François

in European Microscopy and Analysis (1999), 60(9-11),

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See detailEnquête sur le "pouvoir thérapeutique" des dauphins
Servais, Véronique ULg

in Recherches en Communication (1999), 12

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest ... [more ▼]

Do dolphins have a "therapeutic power?". We devised an experimental study to test the hypothesis that interacting with dolphins improves the learning in autistic children. The ambiguous results suggest that the "therapeutic effect" of animals are very sensitive to the experimental setting designed to demonstrate them. They tend to disappear in very stricly controlled conditions. The study also shows that the hypothesis that talk about "therapeutic effect" of animals are formally analogous to the magical talks about dolphin's "power to heal". [less ▲]

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See detailL’ensoleillement et la structure commerciale des places publiques au centre de Liège
Cornélis, Bernard ULg

in Publications de l'Association Internationale de Climatologie (1999), 11

For many years, shop location has been studied at different scales from a socio-economical point of view. Sunshine, on the other hand, is a local phenomenon well-known especially for climatologists and ... [more ▼]

For many years, shop location has been studied at different scales from a socio-economical point of view. Sunshine, on the other hand, is a local phenomenon well-known especially for climatologists and architects. This case-based contribution shows the relationships existing between sunshine and shop location on squares. [less ▲]

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See detailNanometer scale organization of mixed surfactin/phosphatidylcholine monolayers
Deleu, Magali ULg; Paquot, Michel ULg; Jacques, Philippe ULg et al

in Biophysical Journal (1999), 77(4), 2304-2310

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic ... [more ▼]

Mixed monolayers of the surface-active lipopeptide surfactin-C-15 and of dipalmitoyl phosphatidylcholine (DPPC) were deposited on mica and their nanometer scale organization was investigated using atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS). AFM topographic images revealed phase separation for mixed monolayers prepared at 0.1, 0.25, and 0.5 surfactin molar ratios. This was in agreement with the monolayer properties at the air-water interface indicating a tendency of the two compounds to form bidimensional domains in the mixed systems. The step height measured between the surfactin and the DPPC domains was 1.2 +/- 0.1 nm, pointing to a difference in molecular orientation: while DPPC had a vertical orientation, the large peptide ring of surfactin was lying on the mica surface. The N/C atom concentration ratios obtained by XPS for pure monolayers were compatible with two distinct geometric models: a random layer for surfactin and for DPPC, a layer of vertically-oriented molecules in which the polar headgroups are in contact with mica. XPS data for mixed systems were accounted for by a combination of the two pure monolayers, considering respective surface coverages that were in excellent agreement with those measured by AFM. These results illustrate the complementarity of AFM and XPS to directly probe the molecular organization of multicomponent monolayers. [less ▲]

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See detailShort-term toxicity of various pharmacological agents on the in vitro nitrification process in a simple closed aquatic system
Nimenya, H.; Delaunois, Annie; La Duong, Duc ULg et al

in Alternatives to Laboratory Animals (1999), 27

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures ... [more ▼]

During the treatment of fish diseases, drugs which inhibit the nitrification process can cause acute ammonia toxicity. The same phenomenon can occur when fish are put into a tank without active cultures of nitrifying bacteria. The purpose of this study was to quantify the inhibitory effects of 15 pharmacological agents, which are often used as therapeutic agents in ichthyopathology, on ammonia removal and nitrate production in a simple closed aquatic system. The experiments were conducted in polyethylene bags containing activated biofilters and synthetic water solutions, held in a water bath. Ammonia was added to initiate the nitrification process, and graded concentrations of various pharmacological agents were added. The effects of the pharmacological agents on in vitro nitrification were assessed by monitoring ammonia and nitrate concentrations compared to controls with no added agents, for 24 hours. Graded concentrations of ampicillin (Albipen(R)), chloramine T, enrofloxacin (Baytril(R)), erythromycin, levamisole, methylene blue and polymyxin B induced dose-dependent inhibitions of ammonia removal and nitrate production. The corresponding linear regression curves showed high correlation coefficients and were highly significant (p < 0.05). The addition of chloramphenicol, copper (II) sulphate, kanamycin disulphate, malachite green, neomycin sulphate, potassium penicillin G, tetracycline and a mixture of trimethoprim and sulphadoxin (Duoprim(TM)) had no significant effects on the nitrification process. A significant dose-related inhibition of nitrate production, but not of ammonia oxidation, was observed with enrofloxacin. The significant correlation (r = 0.940; p < 0.001) between the degrees of inhibition of ammonia oxidation and nitrate production for the various inhibitory pharmacological agents has also been calculated, with a view to validating this method. The data presented suggest that separate tank facilities for hospitalisation or quarantine are necessary when treating diseased fish with ampicillin, enrofloxacin, chloramine T, erythromycin, levamisole, methylene blue or polymyxin B, in order to avoid ammonia poisoning. [less ▲]

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See detailPrognostic Factors in Urothelial Renal Pelvis and Ureter Tumours: a Multicentre Rare Cancer Network Study
Ozsahin, M; Zouhair, A; Villa, S et al

in European Journal of Cancer & Clinical Oncology (1999), 35/5

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter ... [more ▼]

To assess the prognostic factors in patients with transitional-cell carcinoma of the renal pelvis and/or ureter, a series of 138 patients with transitional-cell carcinoma of the renal pelvis and/or ureter was collected in a retrospective multicentre study. 12 patients with distant metastases were excluded from the statistical evaluation. All but 3 patients underwent radical surgery: nephroureterectomy (n=71), nephroureterectomy and lymphadenectomy (n=20), nephroureterectomy and partial bladder resection or transurethral resection (n=20), nephrectomy (n=10), and ureterectomy (n=5). Sixty-one per cent (n=77) of the tumours were located in the renal pelvis, and 21% (n=27) in the ureter (both in 22 [17%]). Following surgery, residual tumour was still present in 33 patients (16 microscopic and 17 macroscopic). Postoperative radiotherapy was given to 45 (36%) patients. The median follow-up period was 39 months. In a median period of 9 months, 66% of the patients relapsed (34 local, 7 locoregional, 16 regional, and 24 distant). The 5- and 10-year survival were 29% and 19%, respectively, in all patients. In univariate analyses, statistically significant factors influencing the outcome were Karnofsky index, pT-classification, pN-classification, tumour localisation, grade, and residual tumour after surgery. Multivariate analysis revealed that independent prognostic factors influencing outcome were pT-classification, the existence of residual tumour, and tumour localisation. In patients with urothelial renal pelvis and/or ureter tumours, a radical surgical attitude is mandatory; and the presence of tumour in the ureter is associated with a poorer prognosis. [less ▲]

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See detailExperimental and theoretical radiative lifetimes, branching fractions and oscillator strengths in Lu II
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg et al

in Monthly Notices of the Royal Astronomical Society (1999), 307

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See detailCD44v6 expression is an independent prognostic factor in node-negative FIGO stage IB cervical carcinoma.
Speiser, P.; KRIDELKA, Frédéric ULg; Tempfer, C. et al

in International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society (1999), 9(2), 160-165

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing ... [more ▼]

Adhesion molecules such as CD44 play an important role in the metastatic cascade by mediating tumor cell interaction with the endothelium and the subendothelial matrix. As a so-called "lymphocyte homing receptor," CD44 is physiologically involved in migration of circulating lymphocytes to lymphatic tissue. In the present study, we investigated the expression of CD44v3 and v6 in 237 patients with stage IB, N0 cervical carcinoma by means of immunohistochemistry. These results were correlated with the GOG score and other prognostic variables. Median follow-up was 82.6 months (39-110 months). Thirty-nine patients recurred and 35 died from disease within the observation period. In univariate analysis, the GOG score, histologic subtype, and CD44v6 expression were statistically significant predictors for poor overall survival (OS). In multivariate (Cox regression) analysis, the GOG score (< 40 vs. 40-120, RR: 1.37 (95% CI: 1.10-1.71); 40-120 vs. > 120, RR: 2.23 (95% CI: 1.28-3.88); P = 0.004), histologic subtype (adenosquamous carcinomas) (RR: 4.56 (95% CI: 1.49-13.92), P = 0.007) and CD44v6 expression (RR: 2.42 (95% CI: 1.14-5.10), P = 0.021) were independent predictors for poor OS. The expression of CD44v3 did not correlate with prognosis. Furthermore we found a strong correlation between CD44v6 expression and lymphovascular space invasion (LVSI) (chi2 = 17.01, P = 0.0001). Tumor expansion into the loco-regional lymphatic system is the preferred way of tumor spread in cervical carcinoma. The strong correlation of CD44v6 with LVSI produces a significant degree of suspicion that cervical carcinoma cells expressing CD44v6 could, by mimicking lymphocytes, exploit their pathways. [less ▲]

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See detailThe SFSTP guide on the validation of chromatographic methods for drug bioanalysis: from the Washington Conference to the laboratory
Hubert, Philippe ULg; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Analytica Chimica Acta (1999), 391(2), 135-148

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data ... [more ▼]

On the basis of the guidelines given in the Washington Conference report and the ICH (International Conference of Harmonisation) recommendations some suggestions about experimental design and data evaluation are proposed by an SFSTP Commission dedicated to the validation of chromatographic methods in bioanalysis. In a series of meetings, members of this Commission have tried to elaborate a rational, practical and statistically reliable strategy to assure the quality of the analytical results generated. This strategy has been formalised in a guide and the main suggestions made by the Commission are summarised in the present paper. The SFSTP guide has been produced to help analysts from the pharmaceutical industry to validate their bioanalytical methods, It is the result of a consensus between professionals having expertise in bioanalytical and/or statistical fields. The suggestions presented in this paper should therefore help the analyst to design and perform the minimum number of validation experiments needed to obtain all the required information to establish and demonstrate the reliability of its analytical procedure. The SFSTP guide suggests a validation strategy in two steps: a pre-validation and the validation itself. An experimental design is described for each of these steps and the main aspects discussed in the paper are related to the selection of the most appropriate calibration model to fit experimental data and the most suitable way to determine the limit(s) of quantitation and subsequently the calibration range as well as the optimum number of experiments to be performed in the validation phase. (C) 1999 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailLa césarienne dans l'espèce bovine
Hanzen, Christian ULg; Lourtie, O; Ectors, Francis

in Annales de Médecine Vétérinaire (1999), 143

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See detailHypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.
Minet, E.; Mottet, Denis ULg; Michel, G. et al

in FEBS Letters (1999), 460(2), 251-6

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear ... [more ▼]

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH-Per-aryl hydrocarbon nuclear translocator (ARNT)-Sim (PAS) factors Sim and aryl hydrocarbon receptor (Ahr). The transcription factor hypoxia-inducible factor-1alpha (HIF-1alpha), involved in the response to hypoxia, also belongs to the bHLH-PAS family. This work was aimed to investigate the putative role of Hsp90 in HIF-1 activation by hypoxia. Using a EGFP-HIF-1alpha fusion protein, co-immunoprecipitation experiments evidenced that the chimeric protein expressed in COS-7 cells interacts with Hsp90 in normoxia but not in hypoxia. We also demonstrated that Hsp90 interacts with the bHLH-PAS domain of HIF-1alpha. Moreover, Hsp90 is not co-translocated with HIF-1alpha into the nucleus. At last, we showed that Hsp90 activity is essential for HIF-1 activation in hypoxia since it is inhibited in the presence of geldanamycin. These results indicate that Hsp90 is a major regulator in HIF-1alpha activation. [less ▲]

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See detailPubertal Growth as a Determinant of Adult Height in Boys with Constitutional Delay of Growth and Puberty
Rensonnet, Claudie ULg; Kanen, F.; Coremans, C. et al

in Hormone Research (1999), 51(5), 223-9

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult ... [more ▼]

In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (-0. 6 +/- 0.8, mean +/- SD) was similar to target height (-0.5 +/- 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty. Copyrightz1999S. KargerAG,Basel [less ▲]

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See detailFlow cytometry estimation of nuclear size and ploidy level of habituated calli of sugar beet
Kevers, Claire ULg; Greimers, Roland ULg; Franck, Thierry ULg et al

in Biologia Plantarum (1999), 42(3), 321-332

A fully habituated (auxin- and cytokinin-independent) self-regenerating (organogenic) sugar beet cell line (HO) and a fully habituated non-organogenic one (HNO) derived from the former one, were analyzed ... [more ▼]

A fully habituated (auxin- and cytokinin-independent) self-regenerating (organogenic) sugar beet cell line (HO) and a fully habituated non-organogenic one (HNO) derived from the former one, were analyzed as to their nuclear size and DNA content. Flow cytometry and image analysis were used and cells of certified diploid leaves of the same sugar beet strain served as controls. The HNO cells had been shown previously to have many characteristics of cancerous cells. The analyses made on leaves and HNO cells indicated the presence of only one population of cycling cells. In HO cells. two cycling populations were detected: the first one had the same DNA content as the leaves while the second one contained two fold more DNA than the first population. HNO cells showed the higher nuclear size and DNA content. HNO cells also showed evidence of aneuploidy. Thus, nuclear size, DNA content and ploidy level increase together with the neoplasic progression to culminate in HNO cells with the loss of organogenic totipotency. [less ▲]

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See detailPretransplant helper T-lymphocyte determination in bone marrow donors: acute graft-versus-host disease prediction and relation with long-term survival
Winandy, Marie ULg; Lewalle, Philippe; Deneys, Véronique et al

in British Journal of Haematology (1999), 105

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency ... [more ▼]

Helper T-lymphocyte precursor (HTLp) frequency from 19 allogeneic bone marrow donors was tested to detect weak antigenic differences with the recipient, and then compared to the outcome. HTLp frequency was estimated in limiting dilution cultures, and HLA-DR and CD 80 expression by stimulating cells was measured by flow cytometry. 12/19 patients experienced acute graft-versus-host disease (aGVHD) grade II–IV. A good correlation was found between high pretransplant HTLp frequency and grade II–IV aGVHD (median: 1/55848 PBMNC for II–IV GVHD versus 1/ 184346 for 0–I GVHD; P¼0·008). Sensitivity was 82%, specificity 63%, negative predictive value 71% and positive predictive value 75%. Long-term survivors also had a lower HTLp median frequency (1/143354) when compared with patients who died as a result of the transplant procedure (1/22100, P < 0·001). No correlation was found between HTLp frequency and HLA-DR or CD80 expression by patient’s cells. We conclude that HTLp frequency estimation can predict, although poorly, acute GVHD risk and long-term survival. [less ▲]

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See detail4-Ethyl-2,3-dihydro-4H-pyrido[3,2-e]-1,2,4-thiadiazine 1,1-dioxide and 4-ethyl-2,3-dihydro-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide
Dupont, L.; Pirotte, Bernard ULg; Podona, T. et al

in Acta Crystallographica (1999), C55

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See detailLes anomalies congenitales des vaisseaux de la base du coeur: "ring" et "sling" vasculaires. A propos d'un cas
Radermecker, M. A.; Massin, M.; Grenade, Thierry ULg et al

in Revue Médicale de Liège (1999), 54(10), 823-8

We present a case of double aortic arch corrected by surgical interruption and full mobilization of the trachea and the esophagus. The vascular malformations of the supraaortic trunks, which form more or ... [more ▼]

We present a case of double aortic arch corrected by surgical interruption and full mobilization of the trachea and the esophagus. The vascular malformations of the supraaortic trunks, which form more or less complete vascular rings encircling the esophagus and the trachea, are reviewed. The different presentations of double aortic arch, aberrant subclavian arteries, and abnormal development of the pulmonary arteries are discussed. [less ▲]

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See detail"Destinataire final" des subsides cherche privilège, note sous Bruxelles, 1e octobre 1997
Lissoir, Bénédicte ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailHigh Prevalence of Low Femoral Bone Mineral Density in Elderly Women Living in Nursing Homes or Community-Dwelling: A Plausible Role of Increased Parathyroid Hormone Secretion
Reginster, Jean-Yves ULg; Deroisy, Rita ULg; Pirenne, H. et al

in Osteoporosis International (1999), 9(2), 121-8

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH ... [more ▼]

The present study was designed to visit elderly women living in nursing homes and to compare their femoral neck bone mineral density (BMD) and circulating levels of parathyroid hormone (PTH) and 25-OH vitamin D (25-OHD) with those of subjects living at home, in the immediate vicinity of the nursing homes. Of 1483 women, aged 70 years and older, who were selected, 993 agreed to participate in this trial. Their femoral neck BMD (n = 993) was measured by dual-energy X-ray absorptiometry, with a specific device installed in a mobile truck. The circulating levels of 25-OHD and PTH were assessed after an overnight fast (n = 748). After stratification for age, there were no significant differences in mean femoral neck BMD values, prevalence of femoral neck osteoporosis, mean serum 25-OHD and prevalence of absolute or relative 25-OHD deficiency between the two groups. Serum levels of PTH were significantly higher in women over 80 years old living in nursing homes, compared with the community-dwelling women. After adjustment for age, a significant relation was found between femoral neck BMD and PTH levels in the whole population (p = 0.004) and in community-dwelling subjects (p = 0.039). When stratifying our population by quartiles of serum PTH values, the odds ratios for femoral neck osteoporosis were significantly increased for the top two quartiles compared with the lowest one both before (p = 0.00146) and after (p = 0.0013) adjustment for age and type of housing. From this study we conclude that femoral osteoporosis is largely underestimated in European women. Living in a nursing home is not, per se, a risk factor for decreased femoral BMD, and circulating PTH levels are a key determinant of low femoral bone density and osteoporosis. [less ▲]

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See detailEncurvadura Lateral de Vigas Metalicas Sujeitas à Acçao do Fogo - Estudo Numerico e Experimental
Vila Real, Paulo; Piloto, Paulo; Franssen, Jean-Marc ULg et al

in Mecânica Experimental (1999), 4

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