References of "Scientific journals"
     in
Bookmark and Share    
See detailEvaluacion isocinetica de las ligamentoplastias de rodilla
Croisier, Jean-Louis ULg; Villanueva, F. J.; Delcour, J. P. et al

in Utilidad de la reeducacion. Inflamación (1996), 7

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detailBrain hypometabolism of glucose in anorexia nervosa: Normalization after weight gain
Delvenne, Véronique; Goldman, Serge; De Maertelaer, Viviane et al

in Biological Psychiatry (1996), 40(8), 761-768

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex ... [more ▼]

Using positron emission tomography and (18-F)-fluorodeoxyglucose, we studied cerebral glucose metabolism in 10 anorectic girls within their underweight state and after weight gain. Ten age- and sex-matched healthy volunteers were used as controls. Both groups were scanned during rest, eyes closed and with low ambient noise. In absolute values, the underweight anorectic patients, when compared to control subjects, showed a global (p = 0.002) and regional (p ≤ 0.001) hypometabolism of glucose which normalized with weight gain. In relative values, no global difference could be assessed between underweight anorectic patients and controls but a trend can, nevertheless, be observed toward parietal and superior frontal cortex hypometabolism associated with a relative hypermetabolism in the caudate nuclei and in the inferior frontal cortex. After weight gain, all regions normalized for absolute and relative values, although a trend appears toward relative parietal hypometabolism and inferior frontal cortex hypermetabolism in weight gain anorectic patients. Absolute brain glucose hypometabolism might result from neuroendocrinological or morphological aspects of anorexia nervosa or might be the expression of altered neurotransmission following deficient nutritional state. As some differences exists in relative values in underweight patients and tend to persist in weight gain states, this could support a potential abnormal cerebral functioning, a different reaction to starvation within several regions of the brain or different restoration rates according to the region. [less ▲]

Detailed reference viewed: 45 (1 ULg)
See detailLe Maître et son hypertexte
Vromans, Joseph ULg

in Etudes & Travaux (1996), I

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailA Novel Oxidizing Reagent Based on Potassium Ferrate(VI)
Delaude, Lionel ULg; Laszlo, Pierre ULg

in Journal of Organic Chemistry (1996), 61(18), 6360-6370

A new, efficient preparation has been devised for potassium ferrate(VI) (K(2)FeO(4)). The ability of this high-valent iron salt for oxidizing organic substrates in nonaqueous media was studied. Using ... [more ▼]

A new, efficient preparation has been devised for potassium ferrate(VI) (K(2)FeO(4)). The ability of this high-valent iron salt for oxidizing organic substrates in nonaqueous media was studied. Using benzyl alcohol as a model, the catalytic activity of a wide range of microporous adsorbents was ascertained. Among numerous solid supports of the aluminosilicate type, the K10 montmorillonite clay was found to be best at achieving quantitative formation of benzaldehyde, without any overoxidation to benzoic acid. The roles of the various parameters (reaction time and temperature, nature of the solvent, method of preparation of the solid reagent) were investigated. The evidence points to a polar reaction mechanism. The ensuing procedure was applied successfully, at room temperature, to oxidation of a series of alcohols to aldehydes and ketones, to oxidative coupling of thiols to disulfides, and to oxidation of nitrogen derivatives. At 75 degrees C, the reagent has the capability of oxidizing both activated and nonactivated hydrocarbons. Toluene is turned into benzyl alcohol (and benzaldehyde). Cycloalkanes are also oxidized, in significant (30-40%) yields, to the respective cycloalkanols (and cycloalkanones). Thus, potassium ferrate, used in conjunction with an appropriate heterogeneous catalyst, is a strong and environmentally friendly oxidant. [less ▲]

Detailed reference viewed: 56 (4 ULg)
Full Text
Peer Reviewed
See detailInterregional correlation of cerebral glucose metabolism in unmedicated schizophrenia
Biver, Françoise; Goldman, Serge; De Maertelaer, Viviane et al

in European Neuropsychopharmacology (1996), 6(2), 141-147

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in ... [more ▼]

To investigate metabolic relationships between different brain regions in schizophrenia, we measured regional brain metabolism using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) in 15 unmedicated schizophrenic patients and 15 healthy subjects. We analyzed correlations between glucose metabolism data of multiple brain regions using factorial analysis and correlation coefficient comparisons. Absolute regional intercorrelations in schizophrenic brains were found to be significantly stronger than in controls, in relationship to the greater variability of metabolic rates in schizophrenic patients. Variability of normalized metabolic rates and regional intercorrelations were not significantly different between schizophrenic patients and control subjects. We conclude that a global metabolic factor accounts for the variability of metabolic data in untreated schizophrenia. [less ▲]

Detailed reference viewed: 24 (1 ULg)
Peer Reviewed
See detailLa greffe de cellules souches hematopoietiques (greffe de moelle osseuse"): indications, modalites et risques."
Beguin, Yves ULg

in Revue Médicale de Liège (1996), 51(4), 270-5

Detailed reference viewed: 47 (9 ULg)
Full Text
Peer Reviewed
See detailModelling irregularly sampled profiles of nonnegative dog triglyceride responses under different distributional assumptions
Lambert, Philippe ULg

in Statistics in Medicine (1996), 15

General methodology for modelling series of non-negative data observed at unequally spaced times is developed. The parameterization enables both the importance of the serial association, as well the order ... [more ▼]

General methodology for modelling series of non-negative data observed at unequally spaced times is developed. The parameterization enables both the importance of the serial association, as well the order of this dependence to be expressed. An example is given where the effects of three fibre based diets on dog triglyceride profiles are analysed and compared. Many different types of models based on common distributions such as the normal, exponential, gamma, Weibull and log-normal observations are presented. Comparison of possibly non-nested models fitted on the same data set is made using the Akaike criterion. [less ▲]

Detailed reference viewed: 15 (1 ULg)
Full Text
Peer Reviewed
See detailTowards concerted river management in Belgium.
Mormont, Marc ULg

in Journal of Environmental Planning & Management (1996), 39(1), 131-141

River basin management is a highly complex issue, involving scientific uncertainties and competing interests between many groups. One approach is to build consensus between different users and to agree a ... [more ▼]

River basin management is a highly complex issue, involving scientific uncertainties and competing interests between many groups. One approach is to build consensus between different users and to agree a common basis for operation. The King Baudouin Foundation in Belgium has supported the idea of 'river contracts' as a way of producing agreed strategies for river management. Examples of early contracts are described and their wider significance reviewed. [less ▲]

Detailed reference viewed: 7 (0 ULg)
Peer Reviewed
See detailClinical and angiographic outcome of elective stent implantation in small coronary vessels: an analysis of the BENESTENT trial.
Keane, D.; Azar, A. J.; de Jaegere, P. et al

in Seminars in interventional cardiology : SIIC (1996), 1(4), 255-62

We examined the influence of vessel size using an intention-to-treat approach in 259 patients who underwent stent implantation and in 257 patients who underwent balloon angioplasty alone in the BENESTENT ... [more ▼]

We examined the influence of vessel size using an intention-to-treat approach in 259 patients who underwent stent implantation and in 257 patients who underwent balloon angioplasty alone in the BENESTENT trial. In the stented population, smaller vessel size was associated with a higher stent:vessel ratio, a greater relative gain and a greater subsequent loss index, and a higher risk of adverse cardiac events. In the balloon angioplasty population small vessel size conveyed an increased requirement for revascularization but did not increase the risk of procedural failure or myocardial infarction during follow-up. Logistic regression indicated that decreasing vessel size (as a continous variable) was associated with an increasing risk of a cardiac event for both the stent and balloon angioplasty populations. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailClay mineral signature of the NW Atlantic Boundary Undercurrent
Fagel, Nathalie ULg; Robert, Christian; Hillaire Marcel

in Marine Geology (1996), 130(1-2), 19-28

Surface sediments were sampled along 2 transects, across the Iceland and Irminger basins and in the Labrador Sea. Clay mineral assemblages (deduced from X-ray analyses of the carbonate-free <2 mu m ... [more ▼]

Surface sediments were sampled along 2 transects, across the Iceland and Irminger basins and in the Labrador Sea. Clay mineral assemblages (deduced from X-ray analyses of the carbonate-free <2 mu m fraction) are largely dominated by smectites (about 60%) in the Iceland and Irminger basins. In the Labrador Sea, smectites are present along the Greenland Slope, but absent or rare in sediments from the Labrador Slope. They may, however, represent up to 50% of the clay fraction at depths between 2800 and 3400 m along both margins of the Labrador Sea, i.e., along the axis of the Western Boundary Undercurrent (WBUC). A detrital supply from the adjacent continents is unlikely. The WBUC is thought to be responsible for erosion and transport of fine particles from the smectite-rich Irminger and Iceland Basins, then for their redeposition in the Labrador Sea. These results suggest that clay minerals can be used as paleocurrent indicators in the Northwest Atlantic. [less ▲]

Detailed reference viewed: 13 (3 ULg)
Full Text
Peer Reviewed
See detailHeparin-binding domain, type 1 and type 2 repeats of thrombospondin mediate its interaction with human breast cancer cells.
Incardona, F.; Lawler, J.; Cataldo, Didier ULg et al

in Journal of Cellular Biochemistry (1996), 62(4), 431-42

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains ... [more ▼]

Thrombospondin is an adhesive glycoprotein that promotes breast cancer cell adhesion to human vascular endothelial cells (Incardona et al., 1995). In this study, we have identified the molecular domains of thrombospondin that mediate its binding to specific receptors on the human breast adenocarcinoma cell line, MDA-MB-231. Two recombinant fragments from the amino-terminus (TSPN18 and TSPN28), and the fusion proteins of the type 1 and type 2 repeats of human thrombospondin, inhibited binding of radiolabeled thrombospondin to MDA-MB-231 cells in suspension by 40-60% at 50 micrograms/ml whereas the type 3 repeat, carboxy-terminus and unfused glutathione-S-transferase as well as the synthetic peptide Gly-Arg-Gly-Asp-Ser (500 micrograms/ml) had little or no effect. Heparin and various glycosaminoglycans as heparan sulfate, chondroitin sulfates A, B or C, and fucoidan inhibited thrombospondin binding to MDA-MB-231 cells by more than 60% whereas dextran sulfate had only little effect. Treatment of cells with heparitinase, chondroitinase ABC, and hyaluronidase, but not with neuraminidase, induced 30-50% inhibition of thrombospondin binding suggesting the participation of both heparan sulfate and chondroitin sulfate cell surface-associated molecules. Inhibition of proteoglycan sulfation by chlorate or inhibition of glycosaminoglycan chain formation by two beta-D-xylosides also led to a substantial inhibition of thrombospondin binding. Our results indicate that several domains within the thrombospondin molecule, namely the amino-terminus, type 1 and type 2 repeats, participate in its binding to specific receptors bearing sulfated glycosaminoglycans on MDA-MB-231 cells. Biological assays have indicated that, in addition to these domains, the peptide Gly-Arg-Gly-Asp-Ser inhibited MDA-MB-231 cell attachment to thrombospondin suggesting that the last type 3 repeat of the molecule may also contribute to its cell adhesive activity. [less ▲]

Detailed reference viewed: 27 (0 ULg)
Peer Reviewed
See detailEffect of some organophosphate insecticides on acetylcholinesterase of adult Coccinella septempunctata (Coccinellidae)
Bozsik, Andras; Haubruge, Eric ULg; Gaspar, Charles

in Journal of Environmental Science & Health. Part. B, Pesticides, Food Contaminants, & Agricultural Wastes (1996)

Detailed reference viewed: 35 (1 ULg)
Full Text
Peer Reviewed
See detailThe efficacy of a phyto-aromatic ear gel against auricular mange in rabbits and carnivores
Mignon, Bernard ULg; Losson, Bertrand ULg

in Veterinary Record : Journal of the British Veterinary Association (1996), 138

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailOdours identification in the environment by means of mathematical methods
Maternova, Jidrinska; Nicolas, Jacques ULg; Andre, Philippe ULg et al

in Odours & VOC's journal (1996), 1

The aim of the present paper is to test and compare some mathematical discrimination or pattern recognition methods in order to identify one among three air pollution sources.The basic material in this ... [more ▼]

The aim of the present paper is to test and compare some mathematical discrimination or pattern recognition methods in order to identify one among three air pollution sources.The basic material in this work are : - the standard gas chromatography/mass spectrometry analysis with concentrations values for different chemical compounds observed at about hundred sites in iron and steel industries : either coking plants, or cold rolling mills, or coil-coating plants. - the odours levels, measured by the method of dilution at the threshold. Generally speaking, coil-coating plants emit more chemical compounds than two others, however olfactive threshold is about the same in the three cases. Sums of compounds concentrations for different chemical families (e.g. alkanes, alcohol's, phenols, ...) are calculated and used for the mathematical treatments. Because the frequency histogram of the observed concentrations has a log normal distribution, logarithm of concentration is chosen as operating variable instead of concentration itself. The stepwise multiple linear regression is used in order to express the dilution factor at the olfactory perception threshold as a linear combination of the logarithm of concentrations. Results show that this factor can be estimated quite well on the basis of the concentrations of compounds belonging only to three chemical families. Nevertheless, these families differ following the emission source. To perform the optimal odour description of the three types of industrial plants a larger set of compounds families should be examined in a first step. Factor analysis is used with the aim of regrouping observed variables that are linked together in the plane of the first two factors. The representation of observation points is then superposed on this scheme. Some variable clusters are observed. The method, applied to the whole variables set, classes rather well the observations : the three emissions sources are well discriminated. Cluster analysis, discriminant analysis and neural network have also been used, but only with three variables common to all installations : concentrations of alkylbenzenes, polycyclic aromatics and alkanes. Cluster analysis is not a "supervised method". That means that it is free to create itself some groups showing similar behaviour with regard to the observed variables. Indeed, results show that cluster analysis does not allow to recognise the emission source. In discriminant analysis, target groups membership is provided for each set of variables values : it is a supervised method. The classification functions so deduced allow to discriminate quite well the three industrial plants and to predict the emission origin. A total of 87 % of the observations are correctly on the basis of the classification functions. Neural network approach, with backpropagation algorithm, is a so-called "pattern recognition technique" and is also a supervised method. It provides still better results than statistical ones. After the learning phase, the network is able to identify correctly 99.5 % of observations from 95.5 % the training set.The concentrations of compounds belonging to three chemical families, combined with a pattern recognition technique based either on discriminant analysis, or on neural network, prove to be efficient for recognising the source of odorous gaseous effluents. For the data set considered in this paper, the neural network exhibits better classification performances than discriminant analysis, but its learning phase is slower. However, applying one method or the other for further recognition of unknown patterns is quick and easy. [less ▲]

Detailed reference viewed: 27 (1 ULg)
Full Text
Peer Reviewed
See detailParticle Production in a Hadron Collider Rapidity Gap: The Higgs Case
Cudell, Jean-René ULg; Hernandez, Oscar F

in Nucl. Phys. (1996), B471

Detailed reference viewed: 5 (0 ULg)
Peer Reviewed
See detailLocalization of nucleic acids in hepatocyte nucleoli of rats upon D-galactosamine-induced block of transcription.
Mikhaylova, V. T.; Thiry, Marc ULg; Stephanova, E. et al

in Experimental Cell Research (1996), 225(2), 389-98

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection ... [more ▼]

The precise localization of DNA and RNA within rat hepatocyte nucleoli during the process of D-galactosamine-induced nucleolar segregation has been studied by using sensitive methods for their detection: osmium-ammine staining and terminal deoxynucleotidyl transferase reaction for DNA, and immunoelectron microscopy with anti-RNA antibodies, RNase-gold, and autoradiography with tritiated orotic acid for RNA. The blocking of transcription was followed by the disappearance of intranucleolar condensed chromatin. Agglomerates of thin extended DNA filaments were found to change their location to the nucleolar periphery and to coalesce with each other. At the last stage of nucleolar segregation they were concentrated at the pole of the nucleolar fibrillar remnant while the rest of the nucleolus did not contain any DNA. No DNA was found in the dense fibrillar component of both intact and treated hepatocyte nucleoli. During the process of nucleolar segregation the bulk of the nucleolar RNA was found within the so-called spherical bodies. This RNA appeared to be synthesized shortly before or even after drug administration. The results obtained are in agreement with the hypothesis that the fibrillar centers are the site of nucleolar transcription. They also show that uncompleted molecules of pre-rRNA whose synthesis has been blocked are segregated from the rest of nucleolar RNA species into the spherical bodies. [less ▲]

Detailed reference viewed: 15 (0 ULg)
Peer Reviewed
See detailThe Potent Angioinhibin Agm-1470 Stimulates Normal but Not Human Tumoral Lymphocytes
Antoine, Nadine ULg; Daukandt, M.; Locigno, R. et al

in Tumori (1996), 82(1, Jan-Feb), 27-30

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects ... [more ▼]

BACKGROUND: AGM-1470 is a newly synthesized molecule developed as an analog of the potent anti-angiogenic fumagillin. Its efficacy in restraining tumor growth in vivo and the absence of major side effects have already led to phase I clinical trials in patients with solid cancers. However, neither the exact mechanisms of action of AGM-1470 nor its effects on the host of normal cells have been extensively studied. Recently, we showed that AGM-1470 enhanced the proliferation of B lymphocytes in the presence of T cells. Since AGM-1470 could potentially be used in patients with lymphoma, it was urgent to test the effect of the molecule on the proliferation of tumor lymphocytes. METHODS: The possible effect of AGM-1470 on the proliferation of normal or tumor lymphocytes was evaluated by thymidine-incorporated assays. Normal T and B lymphocytes were purified from human tonsils. The tumor lymphocytes used in the study were Molt 3, Molt 4 and Jurkatt cell lines for the T lineage and Daudi and Radji cell lines for the B lineage. RESULTS: As shown previously, AGM-1470 stimulates the proliferation of normal B lymphocytes through an action on normal T cells. THe angioinhibin was ineffective ont eh proliferation of both T and B transformed cells. Moreover, in the presence of the drug, tumor T cells co-cultured with normal B lymphocytes did not induce any increase in B cell proliferation, as previously observed with normal T lymphocytes. Inversely, tumor B cells co-cultured with normal T lymphocytes were insensitive to the drug. CONCLUSIONS: Our results demonstrate that AGM-1470 is ineffective on lymphoid tumor cell proliferation and could potentially be safely administered to lymphoma patients. [less ▲]

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailAcute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine.
Louis, Renaud ULg; Radermecker, Maurice ULg

in European Respiratory Journal (1996), 9(7), 1414-20

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in ... [more ▼]

Platelet-activating factor (PAF) may play a role in the pathophysiology of asthma but controversies exist about bronchial responsiveness toward this mediator in asthma. We have compared the variations in the specific conductance (sGaw) and forced expiratory volume in one second (FEV1) in 12 asthmatics and 12 normal subjects after inhalation of doubling doses of PAF (15-120 micrograms) and methacholine (18 to at least 144 micrograms). In order to take into account a possible tachyphylaxis, we compared PAF dose-response curves performed on one day with the curves obtained by giving the same doses separately on different days. Repeated inhalations of doubling doses of PAF caused sGaw and FEV1 to plateau after the second dose in each group, whereas methacholine provoked a dose-related decrease in sGaw and FEV1. A dose-dependent decrease in the functional indices was restored when the different doses of PAF were administered on separate days. In both groups, the fall in sGaw after inhalation of 60 micrograms as a single dose was higher than that achieved when this dose was given during a full bronchial challenge. The falls in sGaw and FEV1 after PAF inhalation were significantly higher in the asthmatics than in the normal subjects. The provocative dose of PAF causing a 35% fall in sGaw (PD35,sGaw) PAF was only twofold lower in the asthmatics than in the normal subjects (p < 0.05), while it was 11 fold lower for methacholine (p < 0.001). When the PD35,sGaw values were compared, PAF was found on a molar basis to be 33 fold more potent than methacholine in the normal subjects, but only fivefold more potent in the asthmatics (p < 0.05). The percentage falls in FEV1 (calculated by interpolation) for a 35% fall in sGaw, were greater in asthmatics than in normals both for methacholine (p < 0.05) and PAF (p = 0.09). Our results demonstrate a tachyphylaxis after inhalation of platelet-activating factor in normal subjects and asthmatics, and show that asthmatics develop a greater bronchial obstruction than normal subjects even if methacholine is more sensitive than platelet-activating factor at discriminating between the two groups. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailPlace de la nalbuphine (Nubain) dans l'arsenal analgésique moderne
SENARD, Marc ULg; Tazarourte, K.; Darmon, P. L.

in Urgences médicales (1996), 15

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailLes "deux cultures" et la tâche de la philosophie
Bouquiaux, Laurence ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1996)

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailMagnetic alignment in 2212 Bi-based superconducting system .1. Magnetic orientation of Bi2Sr2Ca1-x(RE)(x)Cu2O8-y [(RE)=Gd, Dy, Ho, Er] powder dispersed in epoxy resin at room temperature
Stassen, S.; Cloots, Rudi ULg; Vanderbemden, Philippe ULg et al

in Journal of Materials Research (1996), 11(5), 1082-1085

The magnetic anisotropy of rare-earth substituted 2212 materials (Bi(2)Sr(2)Ca(0.8)RE(0.2)Cu(2)O(x) with RE = Gd, Dy, Ho, Er) is put into evidence. Superconducting powder dispersed in epoxy resin is ... [more ▼]

The magnetic anisotropy of rare-earth substituted 2212 materials (Bi(2)Sr(2)Ca(0.8)RE(0.2)Cu(2)O(x) with RE = Gd, Dy, Ho, Er) is put into evidence. Superconducting powder dispersed in epoxy resin is oriented under an external magnetic field (4 T) in a direction that depends on the nature of the rare-earth used in the substitution. Both directions of observation (parallel or perpendicular to the field) were investigated. Splitting of (00l) peaks is neatly observed and discussed. [less ▲]

Detailed reference viewed: 30 (6 ULg)
Full Text
Peer Reviewed
See detailThe Creb, Atf-1, And Atf-2 Transcription Factors From Bovine Leukemia Virus-Infected B Lymphocytes Activate Viral Expression
Adam, E.; Kerkhofs, P.; Mammerickx, M. et al

in Journal of Virology (1996), 70(3),

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailMise au point relative à l'utilisation de la gonadolibérine en reproduction bovine. 1. Justifications physiologiques de son application au traitement de l'infertilité
Hanzen, Christian ULg; Houtain, Jean Yves; Laurent, Yves

in Médecin Vétérinaire du Québec (1996), 26(1), 7-10

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailRetard neuromoteur et neuropsychologique: critères de recours à une prise en charge spécialisée
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia et al

in Percentile (1996), .(3), 103-107

Detailed reference viewed: 54 (8 ULg)
Full Text
Peer Reviewed
See detailR. Sacré, « Musiques Cajun, Créole et Zydeco »
Pirenne, Christophe ULg

in Revue de la Société liégeoise de Musicologie (1996), 4

Detailed reference viewed: 27 (10 ULg)
Peer Reviewed
See detailUsefulness of fluoxetine in obese non-insulin-dependent diabetics: a multicenter study.
Daubresse, Jean-Claude; Kolanowski, J.; Krzentowski, G. et al

in Obesity Research (1996), 4(4), 391-6

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent ... [more ▼]

Weight reduction is essential in the management of most non-insulin-dependent diabetics, but this therapeutical goal is difficult to obtain. In this double-blind parallel study, 82 non-insulin-dependent diabetics, moderately obese (BMI = 30 - 39 kg/m2), were given for an 8-week period either placebo (P) or fluoxetine (F), a specific serotonin reuptake inhibitor, in addition to their usual antidiabetic treatment. Thirty-nine of them received 60 mg fluoxetine a day and 43 were given the placebo. At admission, both groups had similar weight excess, metabolic control and serum lipid values. In comparison with the P-treated subjects, those treated with fluoxetine (F) lost more weight after 3 weeks (-1.9 vs. -0.7 kg, p < -0.0009) and after 8 weeks (-3.1 vs. -0.9 kg, p < 0.0007). Fasting blood glucose decreased in group F after 3 weeks (-1.5 vs -0.4 mmol/L, p < 0.003) and after 8 weeks (-1.7 vs. -0.02 mmol/L, p < 0.0004). HbAlc decreased from 8.5% to 7.7% in group F and from 8.6% to 8.3% in group P (p = 0.057). Mean triglyceride level was also reduced in group F after 8 weeks (p = 0.042). Fasting C-peptide did not change in either group, but fasting insulin values decreased in group F after 3 weeks (p < 0.02) and after 8 weeks (p < 0.05). The insulin/C-peptide molar ratio decreased significantly in group F after 3 weeks (p < 0.04) and after 8 weeks (p < 0.05) in comparison with group P. The drug was generally well tolerated and no major side effects were reported. In conclusion, the addition of fluoxetine to the usual oral hypoglycemic agent therapy might be beneficial in obese non-insulin-dependent diabetics, at least on a short-term basis. [less ▲]

Detailed reference viewed: 51 (0 ULg)
Peer Reviewed
See detailEffects of PEEP on abdominal aortic input impedance
LAMBERMONT, Bernard ULg; DETRY, Olivier ULg; FOSSION, A et al

in Intensive Care Medicine (1996), 22

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailComposition of the essential oil of Piper acutifolium Ruiz. and Pav. from Peru.
Lognay, Georges ULg; Bouxin, P.; Marlier, M. et al

in Journal of Essential Oil Research (1996), 8(6),

Detailed reference viewed: 72 (3 ULg)
Full Text
Peer Reviewed
See detailThe holodisc distance transform and its applications in image analysis
Pirard, Eric ULg

in Microscopy, Microanalysis, Microstructures (1996), 7

Detailed reference viewed: 14 (2 ULg)
Peer Reviewed
See detailLa négation bn ... iwnA en néo-égyptien
Winand, Jean ULg

in Lingua Aegyptia [= LingAeg] (1996), 5

Detailed reference viewed: 37 (6 ULg)
See detailLa bryoflore d'une mosaïque alluviale rhénane: la réserve naturelle de la Petite Camargue Alsacienne (Haut-Rhin)
Vanderpoorten, Alain ULg; Klein, J. P.; Jaegly, E. et al

in Bulletin de la Société Botanique du Centre-Ouest (1996), 27

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailBiogeography and taxonomy of Apodemus sylvaticus (the woodmouse) in the Tyrrhenian region: Enzymatic variations and mitochondrial DNA restriction pattern analysis
Michaux, Johan ULg; Filippucci, M. G.; Libois, Roland ULg et al

in Heredity (1996), 76(Part 3), 267-277

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown ... [more ▼]

In the western Mediterranean area, the taxonomic status of the various forms of Apodemus sylvaticus is quite unclear. Moreover, though anthropogenic, the origins of the island populations remain unknown in geographical terms. In order to examine the level of genetic relatedness of insular and continental woodmice, 258 animals were caught in 24 localities distributed in Belgium, France, mainland Italy, Sardinia, Corsica and Elba. Electrophoresis of 33 allozymes and mtDNA restriction fragments were performed and a UPGMA dendrogram built from the indices of genetic divergence. The dendrogram based on restriction patterns shows two main groups: 'Tyrrhenian', comprising all the Italian and Corsican animals and 'North-western', corresponding to all the other mice trapped from the Pyrenees to Belgium. Since all the Tyrrhenian mice are similar and well isolated from their relatives living on the western edge of the Alpine chain, they must share a common origin. The insular populations are consequently derived from peninsular Italian ones. From a taxonomic point of view and taking the priority rules into account, we have to invalidate A. s. clanceyi Harrison, 1948 and to consider the Tyrrhenian woodmice as belonging to A. s. milleri de Beaux, 1926, whereas the North-western ones must be referred to as the nominal subspecies. As far as the Elban woodmouse is concerned, at the moment we prefer to keep its present subspecific status because we only studied one animal. [less ▲]

Detailed reference viewed: 70 (6 ULg)
Peer Reviewed
See detailA single editing event is a prerequisite for efficient processing of potato mitochondrial phenylalanine tRNA
MarechalDrouard, L.; Cosset, A.; Remacle, Claire ULg et al

in Molecular & Cellular Biology (1996), 16(7), 3504-3510

In bean, potato, and Oenothera plants, the C encoded at position 4 (C-4) in the mitochondrial tRNA(GAA)(Phe) gene is converted into a U in the mature tRNA, This nucleotide change corrects a mismatched C-4 ... [more ▼]

In bean, potato, and Oenothera plants, the C encoded at position 4 (C-4) in the mitochondrial tRNA(GAA)(Phe) gene is converted into a U in the mature tRNA, This nucleotide change corrects a mismatched C-4-A(69) base pair which appears when the gene sequence is folded into the cloverleaf structure. C-to-U conversions constitute the most common editing events occurring in plant mitochondrial mRNAs. While most of these conversions introduce changes in the amino acids specified by the mRNA and appear to be essential for the synthesis of functional proteins in plant mitochondria, the putative role of mitochondrial tRNA editing has not yet been defined. Since the edited form of the tRNA has the correct secondary and tertiary structures compared with the nonedited form, the two main processes which might be affected by a nucleotide conversion are aminoacylation and maturation. To test these possibilities, we determined the aminoacylation properties of unedited and edited potato mitochondrial tRNA(Phe) in vitro transcripts, as well as the processing efficiency of in vitro-synthesized potato mitochondrial tRNA(Phe) precursors. Reverse transcription-PCR amplification of natural precursors followed by cDNA sequencing was also used to investigate the influence of editing on processing. Our results show that C-to-U conversion at position 4 in the potato mitochondrial tRNA(GAA)(Phe) is not required for aminoacylation,vith phenylalanine but is likely to be essential for efficient processing of this tRNA. [less ▲]

Detailed reference viewed: 5 (0 ULg)
Full Text
See detailL’éducation géographique. Pour une vision citoyenne du monde
Merenne-Schoumaker, Bernadette ULg

in Géographes Associés (1996), (19), 65-69

Brief reflection on the place of the teaching of geography in education for citizenship

Detailed reference viewed: 15 (0 ULg)
See detailWhat policies for biodiversity management in the Wallonia region? Biodiversity and its audiences: Sociological reflections on biodiversity protection
Mormont, Marc ULg

in Annales de Gembloux (1996), 102(1-2), 19-30

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a ... [more ▼]

Current popular concepts of biodiversity are examined, with particular application to Belgium, using a three stage analysis. The way in which the link was made between a scientific concept and a sociopolitical definition is analysed. Consideration is made of society's idea of 'nature' and the 'return to nature' concept. Ways in which the public can adapt its behaviour and ideals to protect biodiversity (local ecology programmes, environmentally friendly farming etc) are examined. [less ▲]

Detailed reference viewed: 22 (13 ULg)
Full Text
Peer Reviewed
See detailBiodegradable and macroporous polylactide implants for cell transplantation : 1. Preparation of macroporous polylactide supports by solid-liquid phase separation
Schugens, Ch; Maquet, Véronique; Grandfils, Christian ULg et al

in Polymer (1996), 37(6), 1027-1038

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing ... [more ▼]

Freeze-drying of polylactide solutions in 1,4-dioxane has been studied as a way to produce microcellular foams. The thermally induced phase separation has been studied in relation to several processing and formulation parameters. The effects of polymer concentration, chain stereoregularity, polymer molecular weight and cooling rate have been investigated in connection with the porous morphology and the physico-mechanical characteristics of the final foams. As a rule, bundles of channels are formed with a diameter of ~100 μ.m. They have a preferential orientation that fits the cooling direction. A porous substructure (~10 μm) is observed in the internal walls of the tubular macropores. Variations in this general porous morphology-and particularly in the porosity, density, solvent residue, mechanical resistance and degree of regularity in the spatial organization of pores-have been observed when polymer concentration in 1,4-dioxane and polylactide stereoregularity are changed. As expected, cooling rate has a strong effect on the foam morphology, which is essentially controlled by the solvent crystallization. Pores are nothing but the fingerprints of 1,4-dioxane crystallites. [less ▲]

Detailed reference viewed: 70 (14 ULg)
Peer Reviewed
See detailGastrin levels in serum and bronchoalveolar lavage fluid of patients with lung cancer: comparison with patients with chronic obstructive pulmonary disease.
Dowlati, A; Bury, Thierry ULg; CORHAY, Jean-Louis ULg et al

in Thorax (1996), 51(12), 1270-2

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and ... [more ▼]

BACKGROUND: The gastrin gene is known to be expressed in all classes of bronchogenic carcinomas. Furthermore, high levels of gastrin have been reported in both the bronchoalveolar lavage (BAL) fluid and serum of patients with lung cancer. Based on these preliminary data a study was conducted to evaluate the usefulness of gastrin measurements in the diagnosis and staging of lung cancer. METHODS: Thirty-five patients with lung cancer (26 non-small cell (NSCLC) and nine small cell (SCLC)) and 25 patients with chronic obstructive pulmonary disease underwent fibreoptic bronchoscopy and BAL. Gastrin levels were determined in both BAL fluid and the serum and compared with each other and with staging. RESULTS: No difference was found between the gastrin levels in the BAL fluid or serum of the study groups. There was no correlation with the stage in NSCLC and no correlation was found between the gastrin levels in the serum and the BAL fluid. A significant difference was seen in gastrin levels in BAL fluid between extensive and limited SCLC (p < 0.05). CONCLUSION: There is no evidence of clinical usefulness for gastrin measurements in lung cancer. [less ▲]

Detailed reference viewed: 8 (3 ULg)
Peer Reviewed
See detailDivorce et annulation du mariage simulé
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1996)

Detailed reference viewed: 83 (16 ULg)
Peer Reviewed
See detailLa pratique de la mise en observation psychiatrique
Boxho, Philippe ULg

in Revue Médicale de Liège (1996), 52

Detailed reference viewed: 43 (1 ULg)
Peer Reviewed
See detailProbabilities for forbidden transitions in atoms and ions: 1989-1995. A commented bibliography
Biémont, Emile ULg; Zeippen, C. J.

in Physica Scripta (1996), T65

Detailed reference viewed: 9 (1 ULg)
Full Text
Peer Reviewed
See detailAlpha-MSH stimulates neurite outgrowth of neonatal rat corticospinal neurons in vitro.
Joosten, E. A.; Verhaagh, S.; Martin, Didier ULg et al

in Brain Research (1996), 736(1-2), 91-8

Peptides related to melanocortin (alpha MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in ... [more ▼]

Peptides related to melanocortin (alpha MSH) and corticotropin (ACTH), collectively termed melanocortins, exert trophic effects on the outgrowth of neurites from peripheral and central nervous system in vitro. Here we study the neurite outgrowth promoting effect of alpha-MSH on corticospinal (CS) neurons in vitro. Corticospinal neurons were identified in cell culture of neonatal rat cortex by immunostaining of cholera toxin subunit B (CTB), retrogradely transported from the cervical parts of the spinal cord. The CTB-immunoreactive neurons represent a small percentage (3-5%) of the total cell population after 72 h in vitro. The axons or dendrites of cortical and CTB-labelled layer V neurons were visualized using antibodies against axon- or dendrite-specific markers and measured using a semi-automatic quantification device. Here we report that alpha-MSH stimulates axonal as well as dendrite outgrowth from both total and CTB-labelled neurons with a bell-shape response curve. Axonal outgrowth of CTB-labelled neurons was dose-dependently stimulated with a maximal effect of 50% at 10(-10) M alpha-MSH. The maximal effect for stimulation of axon outgrowth for the total cortex population was observed at 10(-8) M alpha-MSH. In addition dendrite outgrowth of both total and CTB-labelled neurons is stimulated in a dose-dependent manner with maximal effects (varying between 46 and 48%) at 10(-8) M alpha-MSH. Explanations in the shift for the optimal alpha-MSH concentration for stimulation of axonal outgrowth of CTB-labelled layer V neurons as compared to total cortex neurons are discussed. [less ▲]

Detailed reference viewed: 38 (0 ULg)
Peer Reviewed
See detailCase management voor psychogeriatrishe patiënten: gezondheidstoestand van deze ouderen en de zorgbelasting van hun centrale verzorgers
Milisen, K.; Borgermans, L.; Dejace, Alain ULg et al

in Acta Hospitalia (1996), 4

Detailed reference viewed: 37 (0 ULg)
Full Text
Peer Reviewed
See detailMyocellular Enzyme Leakage, Polymorphonuclear Neutrophil Activation and Delayed Onset Muscle Soreness Induced by Isokinetic Eccentric Exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Deby-Dupont, G. et al

in Archives of Physiology & Biochemistry (1996), 104(3), 322-9

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product ... [more ▼]

To address the question of whether delayed onset muscular soreness (DOMS) following intense eccentric muscle contraction could be due to increased production of the arachidonic acid derived product prostaglandin E2 (PGE2). 10 healthy male subjects were submitted to eccentric and concentric isokinetic exercises on a Kin Trex device at 60 degrees/s angular velocity. Exercise consisted of 8 stages of 5 maximal contractions of the knee extensor and flexor muscle groups of both legs separated by 1 min rest phases. There was an interval of at least 30 days between eccentric and concentric testing, and the order of the two exercise sessions was randomly assigned. The subjective presence and intensity of DOMS was evaluated using a visual analogue scale, immediately, following 24 h and 48 h after each test. Five blood samples were drawn from an antecubital vein: at rest before exercise, immediately after, after 30 min recovery, 24 h and 48 h after the tests. The magnitude of the acute inflammatory response to exercise was assessed by measuring plasma levels of polymorphonuclear elastase ([EL]), myeloperoxidase ([MPO]) and PGE2 ([PGE2]). Using two way analysis of variance, it appeared that only eccentric exercise significantly increased [EL] and DOMS, especially of the hamstring muscles. Furthermore, a significant decrease in eccentric peak torque of this muscle group only was observed on day 2 after eccentric work (- 21%; P < 0.002). Serum activity of creatine kinase and serum concentration of myoglobin increased significantly 24 and 48 h after both exercise tests. However, these variables reached significantly higher values following eccentric contractions 48 h after exercise. Mean [PGE2] in the two exercise modes remained unchanged over time and were practically equal at each time point. On the basis of these findings, we conclude that the magnitude of polymorphonuclear (PMN) activation, muscle damage, and DOMS are greater after eccentric than after concentric muscle contractions. However, the hypothesized interplay between muscle damage, increased PGE2 production, DOMS sensations, and reduced isokinetic muscle performance was not substantiated by the present results. [less ▲]

Detailed reference viewed: 41 (4 ULg)
Peer Reviewed
See detailFalls among the elderly: a community problem
Reginster, Jean-Yves ULg; Gosset, Christiane ULg; Reginster-Haneuse, G.

in Archives of Public Health (1996), 54

Detailed reference viewed: 8 (3 ULg)
Full Text
Peer Reviewed
See detailOpportunities for using two low-cost methods for treatment of metal bearing aqueous streams
Gaydardzhiev, Stoyan ULg; Hadjihristova, M.; Tichy, R.

in Minerals Engineering (1996), 9

The feasibility of two non-traditional approaches - reedbeds as a natural wetland and adsorption on lignite and its maceral fractions - for their application in metal bearing effluent treatment is ... [more ▼]

The feasibility of two non-traditional approaches - reedbeds as a natural wetland and adsorption on lignite and its maceral fractions - for their application in metal bearing effluent treatment is discussed. The main mechanisms of metals uptake are otulined. The preliminary results from a pilot scale wetland operation for metallurgical effluents purification are analysed. For the second approach - the different maceral fractions derived from coal refining have shown different metal uptake apptitude. Zeta potential studies and adsorption isotherms have explained these findings. [less ▲]

Detailed reference viewed: 22 (6 ULg)
Peer Reviewed
See detailLe diabete non insulinodependant: de la physiopathologie au traitement.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1996), 151(7-9), 395-402402-5

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important ... [more ▼]

Non-insulin-dependent (or type 2) diabetes mellitus is a common, underdiagnosed and growing disease in our society. It is responsible for increased morbidity and mortality and represents an important public health problem. This polygenic disease is often expressed late in life and its evolution is accelerated by environmental factors leading to obesity. It combines defects in both insulin secretion and insulin action, and such defects are present in various proportions according to the type of patient and the stage of the disease. Diet and physical activity recommendations are the basis of the treatment. Current pharmacological approaches aim at improving insulin secretion and/or insulin cellular action. After secondary failure to oral drugs, insulin therapy should be initiated, the patient becoming "insulin-requiring". A synergy should be searched in the combination of various therapeutic modalities in order to improve the glycaemic control. [less ▲]

Detailed reference viewed: 60 (0 ULg)
Full Text
Peer Reviewed
See detailImpact of the microbiology in the epuration processes.
Thonart, Philippe ULg; Destain, Jacqueline ULg; Antoine, Patrice et al

in Cerevisia and Biotechnology (1996), 21(2), 76-79

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at ... [more ▼]

Biological treatments will progressively play a key role in the epuration process. Indeed, they show different advantages like reaction specificity, multiple degradation potentialities and efficiency at very low concentrations of pollutants. Two approaches can be considered for developing biological processes of epuration : addition of bioactivators for improving endogenous microorganisms capabilities or introduction of microorganism starters for accelerating the epuration process. These two ways need as prerequisite a basic knowledge of the metabolic pathways for specific compound degradation and of microbial ecology [less ▲]

Detailed reference viewed: 36 (7 ULg)
Full Text
Peer Reviewed
See detailThe Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment: Deployment on the ATLAS Space Shuttle missions
Gunson, Michael R.; Abbas, M. M.; Abrams, M. C. et al

in Geophysical Research Letters (1996), 23(17), 2333-2336

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events ... [more ▼]

The ATMOS Fourier transform spectrometer was flown for a fourth time on the Space Shuttle as part of the ATLAS-3 instrument payload in November 1994. More than 190 sunrise and sunset occultation events provided measurements of more than 30 atmospheric trace gases at latitudes 3-49 degrees N and 65-72 degrees S, including observations both inside and outside the Antarctic polar vortex. The instrument configuration, data retrieval methodology, and mission background are described to place in context analyses of ATMOS data presented in this issue. [less ▲]

Detailed reference viewed: 43 (4 ULg)
Full Text
Peer Reviewed
See detailGuidelines for authors of medical scientific manuscripts.
Detry, Olivier ULg; Van Damme, Hendrik ULg; Van de Stadt, J.

in Acta Chirurgica Belgica (1996), 96(4), 140-3

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailDemande d'indemnisation des dommages dus aux plans : éléments de recevabilité et de fondement
Delnoy, Michel ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1996)

Detailed reference viewed: 3 (0 ULg)
Full Text
See detailPersistency of lactation yields: A review
Gengler, Nicolas ULg

in Interbull Bulletin (1996), 12

Detailed reference viewed: 7 (1 ULg)
Full Text
Peer Reviewed
See detailExercice physique et ostéoporose
Reginster, Jean-Yves ULg

in Le Monde Médical de la Femme (1996), 309(15), 25-27

Detailed reference viewed: 5 (1 ULg)
Full Text
Peer Reviewed
See detailRelationship between structural properties and affinity for herpes simplex virus type 1 thymidine kinase of bromine substituted 5-heteroaromatic 2'-deoxyuridines
Creuven, Isabelle; Evrard, Christine ULg; Olivier, Anne et al

in Antiviral Research (1996), 30

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the ... [more ▼]

The crystal structures of 5-(5-furan-2-yl)-2'-deoxyuridine (II), 5-(5-bromofuran-2-yl)-2' deoxyuridine (IV) and 5-(3-bromothien-2-yl)-2'-deoxyuridine (V) have been studied in order to explain the different affinity of the compounds for the herpes simplex virus type 1 (HSV-1) thymidine kinase. These compounds present a variable affinity according to the position of the heteroatom substituting the five-membered ring. An unfavourable substitution in the five-membered ring for interaction with the HSV-1 thymidine kinase has been identified. [less ▲]

Detailed reference viewed: 18 (0 ULg)
Peer Reviewed
See detailGlacial-interglacial variability of atmospheric CO2 due to changing continental silicate rock weathering: A model study
Munhoven, Guy ULg; Francois, Louis ULg

in Journal of Geophysical Research (1996), 101(D16), 21423-21437

An 11-box model of the oceanic carbon cycle including sedimentary processes is used to explore the role chemical weathering of continental silicate rocks might play in driving atmospheric CO2 levels on ... [more ▼]

An 11-box model of the oceanic carbon cycle including sedimentary processes is used to explore the role chemical weathering of continental silicate rocks might play in driving atmospheric CO2 levels on glacial-interglacial timescales. Histories for the consumption of CO2 by silicate rock weathering processes are derived from the marine Ge/Si record. Taking the major uncertainties in the knowledge of the Ge and Si cycles into account, several histories for the evolution of the riverine dissolved silica fluxes are calculated from this record. The investigation of the systematics between riverine dissolved silica and bicarbonate fluxes under different weathering regimes leads us to the tentative conclusion that although there is no correlation between dissolved silica and total bicarbonate concentrations in the major rivers, there may exist a negative correlation between weathering intensity and the ratio of dissolved silica to bicarbonate derived from silicate weathering alone. With this correlation as a working hypothesis, it is possible to interpret the dissolved silica fluxes in terms of equivalent CO2 consumption rates. The calculated histories indicate that glacial rates of CO2 consumption by chemical silicate rock weathering could have been twice, and possibly up to 3.5 times, as high as they are today. When used to force the carbon cycle model, they are responsible for glacial-interglacial pCO2 variations in the atmosphere of typically 50–60 ppm and up to 95–110 ppm. These variations are superimposed to a basic oscillation of 60 ppm generated by the model, mainly in response to coral reef buildup and erosion processes. The total pCO2 signal has an amplitude of about 80–90 ppm and up to 125–135 ppm. Although these large amplitudes indicate that silicate weathering processes should be taken into account when studying glacial-interglacial changes of CO2 in the atmosphere, it also raises new problems, such as too high CO2 levels during the period from 110–70 kyr B.P., requiring further study. [less ▲]

Detailed reference viewed: 17 (2 ULg)
See detailA. Kastler (1902-1984)
Biémont, Emile ULg; Glansdorff, P.

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 131-149

Detailed reference viewed: 9 (6 ULg)
Peer Reviewed
See detailL’ὕβρις dans le mythe d'Idas et Lyncée
Renaud, Jean-Michel ULg

in Uranie : Mythes et Littératures (1996), 6

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailThe short duration and anorogenic character of anorthosite magmatism: U-Pb dating of the Rogaland complex, Norway
Schärer, Urs; Wilmart, Edith; Duchesne, Jean-Clair ULg

in Earth & Planetary Science Letters (1996), 139

Detailed reference viewed: 16 (2 ULg)
Peer Reviewed
See detailEvaluation of the cranial rectus abdominus muscle pedicle flap as a blood supply for the caudal superficial epigastric skin flaps in dogs.
Degner, Daniel; Walshaw, Richard; Arnoczky, Steven et al

in Veterinary Surgery : The Official Journal of the American College of Veterinary Surgeons (1996), 25

Detailed reference viewed: 22 (4 ULg)
Full Text
Peer Reviewed
See detailPollution des sols : interventions et responsabilités des pouvoirs publics
Delnoy, Michel ULg

in Sols contaminés, sols à décontaminer (1996)

Detailed reference viewed: 28 (2 ULg)
Full Text
Peer Reviewed
See detailPolymerization of β-butyrolactone initiated with Al(OiPr)3
Kurcok, Piotr; Dubois, Philippe ULg; Jérôme, Robert ULg

in Polymer International (1996), 41(4), 479-485

Polymerization of gamma-butyrolactone has been studied in toluene with Al(OiPr)3 as an initiator. The ring-opening polyaddition proceeds through a coordination-insertion mechanism at a very low rate. Well ... [more ▼]

Polymerization of gamma-butyrolactone has been studied in toluene with Al(OiPr)3 as an initiator. The ring-opening polyaddition proceeds through a coordination-insertion mechanism at a very low rate. Well defined -isopropylester, -hydroxy poly(-butyrolactone)s (PBL) are formed with a narrow molecular weight distribution at low monomer-to-initiator molar ratios, When this ratio is higher (ca. 170), a competition occurs between propagation and side reactions, i.e. elimination, inter- and intra-molecular transesterifications and thermal degradation, which is responsible for a loss of control of the PBL molecular charcteristics. The addition of a Lewis base (1 equivalent of nicotine/Al) to the Al-alkoxide initiator has no significant effect on the polymerization rate, although the chain microstructure is deeply affected since predominantly syndiotactic PBL chains are formed (63% syndio-diads) in contrast to a completely atactic polymer in the absence of nicotine. [less ▲]

Detailed reference viewed: 90 (2 ULg)
Full Text
Peer Reviewed
See detailSubunit 8 of the Saccharomyces cerevisiae cytochrome bc1 complex interacts with succinate-ubiquinone reductase complex.
Bruel, C.; Brasseur, Robert ULg; Trumpower, B. L.

in Journal of Bioenergetics & Biomembranes (1996), 28(1), 59-68

We have investigated the function of subunit 8 of the cytochrome bc1 complex by generating six site-directed mutants, F46C, R51S, P62V, G64A, R91N, and W69-stop, in the cloned QCR8 gene and expressing the ... [more ▼]

We have investigated the function of subunit 8 of the cytochrome bc1 complex by generating six site-directed mutants, F46C, R51S, P62V, G64A, R91N, and W69-stop, in the cloned QCR8 gene and expressing the mutated genes in a Saccharomyces cerevisiae strain in which the chromosomal copy of QCR8 is deleted. The W69-stop mutation impairs assembly of the bc1 complex and growth of yeast on nonfermentable carbon sources as does deletion of QCR8 [Maarse, A. C., De Haan, M., Schoppink, P. J., Berden J. A., and Grivell, L. A. (1988) Eur. J. Biochem. 172, 179-184], implying that the C-terminus of subunit 8 is important for assembly and/or the stability of the bc1 complex. The F46C, R51S, P62V, G64A, and R91N mutations do not affect the growth of yeast on nonfermentable carbon sources, not do they lower the activity or alter the inhibitor sensitivity of the bc1 complex. Rather, some of the mutations increase the cytochrome C reductase activity of the bc1 complex by as much as 40%. However, succinate-ubiquinone reductase activity was consistently reduced 40-60% in mitochondrial membranes from these mutants, while NADH-ubiquinone reductase activity was not affected. In addition, the activation of succinate-ubiquinone reductase activity by succinate was diminished by the F46C, R51S, P62V, and G64A mutations. These results indicate that the cytochrome bc1 complex participates in electron transfer from succinate to ubiquinone in situ and also suggest an interaction between succinate-ubiquinone reductase and cytochrome bc1 complex which involves subunit 8 of the bc1 complex. [less ▲]

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailField evaluation of pregnancy diagnosis using bovine pregnancy-associated glycoprotein (bPAG)
Skinner, J. G.; Gray, D.; Gebbie, F. E. et al

in Cattle Practice (1996), 4(3), 281-284

Detailed reference viewed: 75 (3 ULg)
Full Text
Peer Reviewed
See detailVaricella-zoster virus : a cause of waxing and waning vasculitis. The New England Journal of Medicine case 5-1995 revisited
Gilden, D. H.; Kleinschmidt-DeMasters, B. K.; Wellish, M. et al

in Neurology (1996), 47(6), 1441-1446

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal ... [more ▼]

A 73-year-old man developed an ill-defined fatal vasculitis involving the central nervous system. The case report was published as a clinicopathologic exercise in February 1995 in The New England Journal of Medicine.(1) We restudied the pathologic material and found both varicella tester virus (VZV) DNA and VZV-specific antigen, but not herpes simplex virus (HSV) or cytomegalovirus (CMV) DNA or HSV- or CMV-specific antigen, in three of the five cerebral arteries examined. The inflammatory response, disruption of the internal elastic lamina, and detection of viral antigen were patchy from one artery to another, as well as within a given artery. A search for VZV should be conducted in cases of vasculitis when both the central and peripheral nervous systems are involved, when focal narrowing is present in large arteries, when brain imaging reveals infarction in gray and white matter, both deep and superficial, and when white matter is disproportionally involved. Zosteriform rash is not required for diagnosis. [less ▲]

Detailed reference viewed: 27 (7 ULg)
Peer Reviewed
See detailMarsilio Ficino and Political Syncretism in Ian McEwan's Black Dogs
Delville, Michel ULg

in Notes on Contemporary Literature (1996), XXIV(3), 11-12

Detailed reference viewed: 80 (10 ULg)
Full Text
See detailAutologous stem cell transplantations in elderly AML patients
Archimbaud, E.; Jehn, U.; De Cataldo, F. et al

in Trends in Onco-Hematology (1996), 4(2), 28-29

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailPost-encephalitic extra-pyramidal syndrome associating akinesia and stereotyped movements responsive to L-dopa
Picard, F.; Hirsch, E.; Salmon, Eric ULg et al

in Revue Neurologique (1996), 152(4), 267-271

Detailed reference viewed: 20 (1 ULg)
Full Text
Peer Reviewed
See detailNeonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.
Bakker, Julie ULg; Baum, M. J.; Slob, A. K.

in Neuroscience (1996), 74(1), 251-60

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and ... [more ▼]

Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vomeronasal projection circuit, which responds to reproductively relevant pheromonal cues. The medial preoptic area also receives genital somatosensory inputs via the midbrain central tegmental field and the medial amygdala. We used Fos immunoreactivity as a marker of neuronal activation to determine whether there is a correspondence between the behavioral profiles of neonatally ATD-treated male rats and their neuronal responses in the medial preoptic area and other brain regions to somatosensory and chemosensory stimuli. Achieving eight intromissions with an estrous female led to a greater neuronal Fos immunoreactivity in the medial preoptic area of neonatally ATD-treated male rats compared with neonatally cholesterol-treated male rats. Exposure for 1.5 h to chemosensory cues derived from soiled bedding of estrous females induced Fos immunoreactivity throughout the vomeronasal pathway (i.e. medial amygdala, bed nucleus of the stria terminalis and medial preoptic area) in both ATD and cholesterol males (Experiment 2a). By contrast, exposure for 1.5 h to chemosensory cues derived from soiled bedding of sexually active males revealed clear differences between ATD and cholesterol males in neuronal Fos immunoreactive (Experiment 2b). At peripheral portions of the vomeronasal pathway (i.e. the accessory olfactory bulb and the medial amygdala), there were no differences in the number of Fos immunoreactivity neurons between ATD and cholesterol males. However, neurons in the more central portions of the vomeronasal pathway (i.e. the bed nucleus of the stria terminalis and the medial preoptic area) showed increased Fos immunoreactivity after exposure to odors from sexually active males in ATD males as opposed to cholesterol males. Females, like ATD males, showed neuronal Fos immunoreactivity at each level of the vomeronasal pathway after being exposed to odors from sexually active males. These results suggest that the responsiveness of neurons in the central portion of the vomeronasal projection circuit to odors from sexually active males, but not estrous females, is sexually differentiated in male rats due to the neonatal action of estrogens. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Full Text
Peer Reviewed
See detailAstroglia-released factor with negative allosteric modulatory properties at the GABA A receptor.
Rigo, Jean-Michel; Belachew, Shibeshih ULg; Coucke, Paul et al

in Biochemical Pharmacology (1996), 52(3), 465-473

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta ... [more ▼]

We have previously shown, using whole-cell patch-clamp techniques, that astrocytes release a negative allosteric modulator of the gamma-aminobutyric acid type A receptor (GABAA receptor) with beta-carboline-like properties, thus, likely to act at the benzodiazepine site. Here, using patch-clamp and binding techniques, we confirm that the low-molecular-weight fraction of astroglia-conditioned medium (ACM lmf) contains a factor(s) that negatively modulates GABAA-receptor function. This factor, like beta-carbolines, enhances the specific binding of [35S]t-butyl bicyclophosphorothionate (TBPS) to adult rat cortical membranes in the presence of GABA. However, it fails to interact with various ligands of the benzodiazepine (BZD) site of the GABAA receptor ([3H]flunitrazepam, [3H]Ro 15-1788 and [3H]Ro 15-4513). The question of the actual binding site of the astroglia-derived factor on the GABAA receptor, thus, remains open and can be addressed only after the purification of the active molecule(s) of ACM Imf has been completed, and a labeled form of the endogenous ligand becomes available. Taken together, however, the data suggest that type 1 astrocytes are able to modulate the effects of the main inhibitory neurotransmission in the central nervous system. [less ▲]

Detailed reference viewed: 25 (1 ULg)
Peer Reviewed
See detailRecent advances in prostate cancer metastasis
Waltregny, David ULg; Castronovo, Vincenzo ULg

in Tumori (1996), 82(3, May-Jun), 193-204

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy ... [more ▼]

Prostate cancer in men has now surpassed lung cancer as the most frequent non-cutaneous cancer. From a biological perspective, prostate carcinoma is unique among human malignancies in the wide discrepancy that exists between the prevalence of 'latent' cancer, recognizable only histologically, and that of the clinical disease. Histologically detected localized prostate cancers are heterogeneous, with only a small subset having undergone all of the malignant changes required to produce clinically aggressive tumors. Most of these 'latent' carcinoma never become fully malignant and do not threaten the life or well-being of the host. At present, it is not possible to predict which localized cancers will progress to clinically overt disease. Likewise, many patients have underevaluated and unpredictable extent of their prostate carcinoma, thus resulting in inadequate therapeutic strategies. It is clear that we need to identify molecular and/or cellular markers that are able to define the invasive and metastatic potential of prostate cancer on an individual patient basis. Acquisition of metastatic ability is a definitive criterion by which substage localized prostate cancers. Under the light of recent studies designed to identify some of the features associated with the metastatic phenotype of prostate cancer, the authors review recent advances aimed at gaining insight into those factors that may be involved in prostate cancer metastasis. [less ▲]

Detailed reference viewed: 18 (2 ULg)
Peer Reviewed
See detailContrefaçons liégeoises et maestrichtoises de Beaumarchais. Un exercice bibliographique
Droixhe, Daniel ULg

in Bulletin de l'Institut Archéologique Liégeois (1996), 107

Detailed reference viewed: 23 (2 ULg)
Peer Reviewed
See detailVers une perspective transactionnelle du stress au travail : pistes d'évaluations méthodologiques
De Keyser, Véronique ULg; Hansez, Isabelle ULg

in Cahiers de Médecine du Travail (1996), 33(3), 133-144

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle ... [more ▼]

L'objectif principal de cet article est d'élaborer des pistes d'évaluations méthodologiques pour les études sur le stress au travail. L'approche se base sur une définition du stress axée sur le contrôle de la situation et adopte une conception transactionnelle du stress psychologique au travail insistant sur l'importance de l'évaluation de la situation par l'individu et les processus de coping, dans une perspective diachronique (Mackay et Cooper, 1987). Cet article synthétise les indices utilisés généralement dans les recherches sur le stress au travail et discute leurs limites. Les problèmes méthodologiques envisagés sont les suivants: la difficulté d'établir des relations causales, les problèmes de validité discriminante et convergente, la mise en évidence des effets de chronicité, la fidélité des mesures. Des suggestions sont alors proposées, basées principalement sur une démarche combinant comparaisons intra et inter-individuelles, la méthode des «critical job events» ou approche épidémiologique, les stratégies de triangulation, le tout dans une perspective longitudinale. Pour terminer, des exemples en milieu hospitalier illustrent les démarches proposées. [less ▲]

Detailed reference viewed: 79 (8 ULg)
Full Text
Peer Reviewed
See detailAntimalarial Activity of Cryptolepine and some otrher Anhydronium Bases
Wright, C. W.; Phillipson, J. D.; Awe, S. O. et al

in Phytotherapy Research (1996), 10

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar ... [more ▼]

Eight naturally occurring anhydronium bases and the synthetic quaternary compound Nb-methylharmalane were tested against Plasmodium falciparun (strain K1) in vitro. Cryptolepine was found to have similar activity to that of chloroquine but alstonine, 5,6-dihydroflavopereirine, matadine, Nb-methylharmalane, melinonine F, normelinonine F, strychnoxanthine and serpentine were found to have little activity. Cryptolepine, given orally to mice infected with Plasmodium berghei berghei was found to have moderate antimalarial activity; parasitemia was suppressed by 80% at 50 mg/kg/day. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailChromosomal location of fifteen unique mouse KRAB-containing zinc finger loci
Marine, J. C.; Gilbert, D. J.; Bellefroid, Eric J. et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1996), 7(6), 413-6

The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play ... [more ▼]

The mammalian genome contains hundreds if not thousands of zinc finger protein (Zfp) genes. While the function of most of these genes remains to be determined, it is clear that a few of them play important roles in gene regulation and development. In studies described here, we have used an interspecific mouse backcross mapping panel to determine the chromosomal location of 15 KRAB-containing zinc finger loci. These loci map to nine different mouse autosomes and the X Chromosome (Chr). Two Chrs, 7 and 9, contain cosegregating pairs of KRAB-containing Zfp genes, indicating that the KRAB-containing Zfp genes have evolved through processes involving regional as well as genome-wide duplication events. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Peer Reviewed
See detailComplete Nucleotide Sequence Of Saccharomyces Cerevisiae Chromosome X
Galibert, F.; Alexandraki, D.; Baur, A. et al

in Embo Journal (1996), 15(9),

Detailed reference viewed: 11 (3 ULg)
Peer Reviewed
See detailTheory of the thermal conductivity of metallic localized spin compounds in a magnetic field
Rassili, Ahmed ULg; Ausloos, Marcel ULg

in Journal of Magnetism & Magnetic Materials (1996), 163(1-2), 153-163

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint ... [more ▼]

We calculated the influence of a de magnetic field on the thermal conductivity of localized spin metallic systems as a function of temperature. A variational method was used. The influence of the joint impurity and phonon scattering processes together with the localized spin influence is shown. Remarkable features are found at low temperature and near the critical transition. An increase of conductivity with field near T-C is discussed. It is also argued that a coherent effect due to the field is the cause of the thermal conductivity enhancement at low temperature. The magneto-thermal conductivity is shown at different temperatures. [less ▲]

Detailed reference viewed: 13 (2 ULg)
Full Text
Peer Reviewed
See detailDetermination Of The Taxonomic Position And Characterization Of Yam Mosaic Virus Isolates Based On Sequence Data Of The 5'-Terminal Part Of The Coat Protein Cistron
Duterme, Olivier; Colinet, Dominique; Kummert, Jean et al

in Archives of Virology (1996), 141(6), 1067-1075

Detailed reference viewed: 22 (0 ULg)
Full Text
Peer Reviewed
See detailLes populations de rats noirs insulaires de l'ouest de l'Europe. Essai préliminaire de caractérisation génétique (caryotype et ADN mitochondrial)
Libois, Roland ULg; Torrico, Jorge; Ramalhinho, Maria Graça et al

in Vie et Milieu (1996), 46(3-4), 213-218

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by ... [more ▼]

The colonisation of Europe by the black rat (Rattus rattus) dates back only to the Roman times. This rodent is now widespread all over the continent as well as on many islands where it was introduced by man. In some instances, insular populations are morphologically differentiated by their greater size. In order to study the possible origin of these insular populations, rats were caught on many Mediterranean (Sicily, Sardinia, Lavezzi, Corsica, Elba, Porquerolles) and Atlantic islands (Ré, Oléron, Azores) and compared to animals from continental Europe (Spain), and Africa (Tunisia, Benin). Their karyotype was determined and their mtDNA restriction patterns studied using the HAE III and RSA I endonucleases and a polyacrylamide gel electrophoresis. These patterns appear very similar to each other though one of them is specific to the African animals, probably indicating that Europe and Africa were colonised by different strains. [less ▲]

Detailed reference viewed: 36 (3 ULg)
Peer Reviewed
See detailEvaluation of insuline-like growth horme-I (IGF-I) and their binding proteins (IGFBPs) in pigs
Renaville, Robert ULg; Prandi, Alberto; Claes, Victor et al

in Archivio Veterinario Italiano (1996), 46

Detailed reference viewed: 11 (0 ULg)
See detailReconnaissance des malformations et pathologies prénatales du système nerveux central
Misson, Jean-Paul ULg; Dubru, Jean-Marie ULg; Leroy, Patricia

in Acta Paediatrica Belgica (1996), 28(3), 204-215

Detailed reference viewed: 26 (3 ULg)
Full Text
Peer Reviewed
See detailCurrent therapies for shingles
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Expert Opinion on Investigational Drugs (1996), 5

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but ... [more ▼]

Current management of shingles relies on antiviral therapy. The efficacy of acyclovir in varicella-zoster virus replication is now well established, with a beneficial impact on zoster-associated pain, but its moderate bioavailability renders five oral daily doses mandatory. Recent anti-VZV drug research has been oriented towards agents with increased oral bioavailability. Famciclovir and valaciclovir were originally developed as oral prodrugs for^penciclovir and acyclovir, respectively, but, together with the new antivirals, sorivudine and brovavir, they appear to be effective as oral therapy for shingles. Ongoing clinical trials will determine their relative merits in the management of shingles. The experimental agents H2G, HPMPC, mappicine ketone and A-73209 have potential in the treatment of VZV and are undergoing further investigation and development. [less ▲]

Detailed reference viewed: 28 (0 ULg)
Full Text
Peer Reviewed
See detailModelling of repeated series of count data measured at unequally spaced times
Lambert, Philippe ULg

in Journal of the Royal Statistical Society : Series C (Applied Statistics) (1996), 45

Detailed reference viewed: 11 (0 ULg)
Peer Reviewed
See detailFilmer la dissidence. L'écriture documentaire dans l'oeuvre des frères Dardenne
Van Cauwenberge, Geneviève ULg

in La revue belge du cinéma (1996), 41(hiver), 29-33

Detailed reference viewed: 27 (3 ULg)
Full Text
Peer Reviewed
See detailThe equatorial boundary of the ultraviolet Jovian north aurora observed with multispectral Hubble Space Telescope images
Grodent, Denis ULg; Dols, V.; Gérard, Jean-Claude ULg et al

in Journal of Geophysical Research (1996), 101(E1), 2163-2168

Multispectral observations of the far ultraviolet Jovian aurora with the faint object camera (FOC) on board the Hubble Space Telescope are reported. They are used to describe and compare the morphology ... [more ▼]

Multispectral observations of the far ultraviolet Jovian aurora with the faint object camera (FOC) on board the Hubble Space Telescope are reported. They are used to describe and compare the morphology and the mean brightness of the H-2 Lyman and Werner bands observed at 153, 125, and 130 nm. It is shown that most of the emissions are confined inside the 6 R(J) O-6-GSFC auroral oval and fill a large fraction of the polar cap. During the similar to 50 hours time span of the observations following a very strong aurora, no bright are was observed along the oval mapping the 30 R(J) O-6 oval. Hydrogen emissions at 125 and 130 nm are observed down to 50 degrees N and somewhat below, a region not accessible to previous FOC observations at longer wavelengths. Temporal variations are also observed on timescales of hours to days. [less ▲]

Detailed reference viewed: 12 (3 ULg)
Full Text
Peer Reviewed
See detailDu Dictionnaire général de la langue wallonne à l'Atlas linguistique de la Wallonie
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (1996), 23-24

Detailed reference viewed: 47 (1 ULg)
Peer Reviewed
See detailA preliminary study of parasites and diseases of perch in an intensive culture system
Grignard, Jean-Claude; Mélard, Charles ULg; Kestemont, Patrick

in Journal of Applied Ichthyology (1996), 12

Detailed reference viewed: 10 (0 ULg)
Full Text
Peer Reviewed
See detailPharmacology Of The Hypoglycaemic Sulphonylurea Gliquidone .3. Conformational Analysis
Lins, Laurence ULg; Brasseur, Robert ULg; Malaisse, Wj.

in Pharmacological Research (1996), 34(1-2), 9-10

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond ... [more ▼]

The hypoglycaemic sulphonylurea gliquidone was found, by conformation analysis, to display a U-shaped configuration, with hydrophobic cycles placed at the extremity of each branch and a peptidic bond placed at the bottom of the U. This configuration is similar to that recently observed with the hypoglycaemic sulphonylureas glimepiride and glibenclamide and non-sulphonylurea hypoglycaemic agents of the meglitinide family, such as S3075, repaglinide, A-4166 and KAD-1229. The identification of a conformation common to these various hypoglycaemic drugs may provide an imprint of their binding site at the level of the B-cell sulphonylurea receptor. [less ▲]

Detailed reference viewed: 25 (1 ULg)
Peer Reviewed
See detailNeurophysins in central diabetes insipidus
Legros, Jean-Jacques ULg; Geenen, Vincent ULg

in Hormone Research (1996), 45

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailStromelysin-3 expression promotes tumor take in nude mice
Noël, Agnès ULg; Lefebvre, O.; Maquoi, Erik ULg et al

in Journal of Clinical Investigation (1996), 97

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer ... [more ▼]

Stromelysin-3 (ST3) is a matrix metalloproteinase expressed in human carcinomas in ways suggesting that it may play a role in tumor progression. To test this possibility, we have performed gene transfer experiments using both anti-sense and sense ST3 expression vectors, and malignant cells either expressing (NIH 3T3 fibroblasts) or not (MCF7 epithelial cells) endogenous ST3. We have compared the ability of parental and transfected cells to cause subcutaneous tumor development in nude mice. 3T3 cells expressing anti-sense ST3 RNA showed reduced tumorigenicity, and MCF7 cells expressing mouse or human ST3 were associated with reduced tumor-free period leading to a significant increased tumor incidence(P<10(-4)). However, once established, the ST3 expressing tumors did not grow faster than those obtained with the parental MCF7 cell line. In addition, tumors obtained after sub-cutaneous injection of ST3-expressing or nonexpressing cells did not exhibit obvious histological differences, and careful examination did not reveal any local invasive tissue areas nor systemic metastases. These in vivo observations were in agreement with those obtained in vitro showing that ST3 expression did not modify proliferative nor invasive properties of transfected cells. Altogether, these results indicate that ST3 expression promotes tumor take in nude mice, presumably by favoring cancer cell survival in a tissue environment initially not permissive for tumor growth. These findings represent the first experimental evidence showing that ST3 can modulate cancer progression. [less ▲]

Detailed reference viewed: 14 (0 ULg)
Full Text
See detailLes échouages de cétacés: une méprise magnétique?
Das, Krishna ULg

in Cahiers d'Ethologie (1996), 16(1), 126-130

Detailed reference viewed: 77 (17 ULg)
Peer Reviewed
See detailBequest motives and the level and composition of wealth in Belgium. A survey based analysis
Pestieau, Pierre ULg; Perelman, Sergio ULg

in Cahiers Economiques de Bruxelles (1996), (149), 31-53

Detailed reference viewed: 7 (2 ULg)
Peer Reviewed
See detailEnergetic and conformational study of four benzylimidazole compounds with alpha 2 agonist profile: The mivazerol and three methylated derivatives
Vancampenhout, Nathalie; Dive, Georges ULg; Dehareng, Dominique ULg

in International Journal of Quantum Chemistry (1996), 60(4), 911-930

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either ... [more ▼]

The mivazerol and three of its methylated derivatives are studied at the ab initio SCF level within the MINI-1 and 6-31G basis sets. This study aimed at determining some probable conformations, either neutral or protonated, that could interact with the alpha 2 adrenoceptors. The solvent effect was also studied within the Onsager's solvent model at the two dielectric constant (epsilon) values of 4 and 80. The interaction with the environment (either solvent or receptor) is schematically studied by positioning either two water molecules or one formamide or/and one formic add near the amide and the imidazole for few isomers. The medium polarization, through epsilon, and the solvation effect, through the interaction with the solvent molecules or the receptor side chains, stabilize the same isomers. Post-SCF calculations are performed at the CISD level, the first excited singlet and triplet states energies are determined, and the question of the wave-function stability is addressed. The results indicate the probability of a spin-orbit coupling with the first excited triplet state, thus opening the question of such a possibility within an enzyme active site. (C) 1996 John Wiley & Sons, Inc. [less ▲]

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDifférenciation génétique et morphologique du mulot, Apodemus sylvaticus, dans le bassin Méditerranéen occidental
Michaux, Johan ULg; Libois, Roland ULg; Fons, Roger

in Vie et Milieu (1996), 46(3-4), 193-203

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize ... [more ▼]

Many questions are still unanswered about the biogeography and the origin of the wood mouse in the Mediterranean area, namely on the islands where some giant forms are described. In order to characterize the genetic structure of these insular populations and their level of morphological differentiation, 232 animals originating from 30 localities situated on several western Mediterranean islands and on the continent, either along the sea coast or more inland, were trapped. Their skulls were measured and their mtDNA purified and analysed by RFLP techniques. The wood mice living on small islands are generally bigger than their relatives living on the continent whereas the size of those living on larger islands is quite the same. This kind of insular gigantism ought to be more an adaptive response to peculiar insular environmental conditions (particularly a lower predation pressure) than a consequence of a founder effect. The mtDNA of the wood mice from north-eastern Spain belongs to the previously identified northwestern group (Michaux et al., 1996). Consequently, the Pyrenees are not a biogeographic barrier to the wood mouse. The Sicilian mice, which are genetically different from all the other west European or north-African animals, are morphologically similar to the Sardinian and Italian ones. [less ▲]

Detailed reference viewed: 74 (11 ULg)