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See detailAbility of PMMA to Improve the PC/PVDF interfacial Adhesion
Moussaif, Noureddine; Maréchal, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(3), 658-659

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See detailEnzymes from Cold-Adapted Microorganisms. The Class C Beta-Lactamase from the Antarctic Psychrophile Psychrobacter Immobilis A5
Feller, Georges ULg; Zekhnini, Z.; Lamotte-Brasseur, J. et al

in European Journal of Biochemistry (1997), 244(1), 186-91

A heat-labile beta-lactamase has been purified from culture supernatants of Psychrobacter immobilis A5 grown at 4 degrees C and the corresponding chromosomal ampC gene has been cloned and sequenced. All ... [more ▼]

A heat-labile beta-lactamase has been purified from culture supernatants of Psychrobacter immobilis A5 grown at 4 degrees C and the corresponding chromosomal ampC gene has been cloned and sequenced. All structural and kinetic properties clearly relate this enzyme to class C beta-lactamases. The kinetic parameters of P. immobilis beta-lactamase for the hydrolysis of some beta-lactam antibiotics are in the same range as the values recorded for the highly specialized cephalosporinases from pathogenic mesophilic bacteria. By contrast, the enzyme displays a low apparent optimum temperature of activity and a reduced thermal stability. Structural factors responsible for the latter property were analysed from the three-dimensional structure built by homology modelling. The deletion of proline residues in loops, the low number of arginine-mediated H-bonds and aromatic-aromatic interactions, the lower global hydrophobicity and the improved solvent interactions through additional surface acidic residues appear to be the main determinants of the enzyme flexibility. [less ▲]

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See detailDiazepam-Insensitive Gabaa Receptors on Postnatal Spiral Ganglion Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Michel; Lefebvre, Philippe ULg et al

in Neuroreport (1997), 8(3), 591-6

Using dissociated spiral ganglion cell cultures obtained from 3-day-old rat cochlea, we investigated the response of auditory neurones to gamma-aminobutyric acid (GABA) using patch-clamp techniques. In ... [more ▼]

Using dissociated spiral ganglion cell cultures obtained from 3-day-old rat cochlea, we investigated the response of auditory neurones to gamma-aminobutyric acid (GABA) using patch-clamp techniques. In our recording conditions, GABA elicited inward currents in > 95% of the neurones which reversed around 0 mV. Similar inward currents were measured using isoguvacin, a specific agonist of GABAA receptors. GABA-gated currents were reversibly inhibited by the channel blocker picrotoxin and the GABA competitive antagonist bicuculline. These functional GABAA receptors are characterized by an insensitivity to benzodiazepines and a relatively high sensitivity to beta-carbolines and barbiturates. These results show that the GABAA receptor pharmacological properties of spiral ganglion neurones are close to those of cerebellar granule cells. [less ▲]

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See detailRing-Opening Polymerization of 1,4,8-Trioxaspiro[4.6]-9-undecanone: A new Route to Aliphatic Polyesters Bearing Functional Pendent Groups
Tian, Dong; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Macromolecules (1997), 30(3), 406-409

A straightforward and very efficient pathway has been reported for the synthesis of a functional derivative of ε-caprolactone, i.e. 5-ethylene ketal ε-caprolactone. This new monomer has been ... [more ▼]

A straightforward and very efficient pathway has been reported for the synthesis of a functional derivative of ε-caprolactone, i.e. 5-ethylene ketal ε-caprolactone. This new monomer has been homopolymerized and copolymerized with ε-caprolactone in a well-controlled manner, strongly suggesting absence of any side reactions. Deacetalization of the polyester chains is complete and reduction of the ketone groups into hydroxyl groups as well. No chain scission is observed to occur in the course of these two derivatization reactions. Thus, aliphatic polyesters bearing either ketone pendent groups or hydroxyl pendent groups can be easily prepared, which raises new application prospects. These materials proved to be easily redispersed in an aqueous medium. They form stable colloidal nanodispersions (e.g. 100 nm). These suspensions are stable more than 48 h at room temperature and may be viewed as potential drug colloidal vectors with a core−shell like structure. Different types of reactive groups on the surface of these nanoparticulate vectors are indeed available to the binding of species selected for molecular recognition and drug targeting. For instance, the well-known reactivity of ketones toward primary amines is a direct route to attach peptides onto biodegradable and biocompatible aliphatic polyesters. Poly(ε-caprolactone) with hydroxyl groups reactive toward triethylaluminum provides a macroinitiator for lactone and lactide polymerization, so that biodegradable and biocompatible functional comb, graft, and dendritic aliphatic polyesters can now be synthesized. [less ▲]

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See detailSub-arcsecond imaging and spectroscopy of the radio-loud highly polarized quasar PKS 1610-771.
Courbin, F.; Hutsemekers, Damien ULg; Meylan, G. et al

in Astronomy and Astrophysics (1997), 317

We report on imaging and spectroscopic observations of the radio-loud, highly polarized quasar PKS 1610-771 (z=1.71). Our long-slit spectroscopy of the companion 4.55" NW of the quasar confirms the ... [more ▼]

We report on imaging and spectroscopic observations of the radio-loud, highly polarized quasar PKS 1610-771 (z=1.71). Our long-slit spectroscopy of the companion 4.55" NW of the quasar confirms the stellar nature of this object, so ruling out the previously suspected gravitationally lensed nature of this system. PKS 1610-771 looks fuzzy on our sub-arcsecond R and I images and appears located in a rich environment of faint galaxies. Possible magnification, without image splitting of the quasar itself, by some of these maybe foreground galaxies cannot be excluded. The continuum fuzz (made of the closest two objects, viz. A and D) is elongated in a direction orthogonal to the E vector of the optical polarization, as in high-redshift radio-galaxies. The spectrum of PKS 1610-771 appears strongly curved, in a convex way, with a maximum of intensity at ~7,600Å (2,800AÅ rest frame), possibly indicating a strong ultraviolet absorption by dust. [less ▲]

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See detailLes constellations (I).
Renson, Pierre ULg

in Ciel et Terre (1997), 113

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See detailDiagnostic Value of Exercise Electrocardiography and Angina after Coronary Artery Stenting. Benestent Study Group
Legrand, Victor ULg; Raskinet, B.; Laarman, G. et al

in American Heart Journal (1997), 133(2), 240-8

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent ... [more ▼]

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent implantation and 153 patients assigned to balloon angioplasty enrolled in the Benestent trial comparing de novo stenting with conventional balloon angioplasty. Sensitivity and specificity curves were constructed for the prediction of percentage diameter stenosis and minimal lumen diameter. Receiver-operator curves were constructed for comparison of diagnostic accuracy. Identical exercise load and duration were achieved in the two groups, despite a better angiographic result in patients treated with a stent. Similarly, the diagnostic accuracy of clinical symptoms or exercise test results as a function of the angiographic results were similar in patients with and patients without a stent. The intersection points of the sensitivity and specificity curves for recurrent angina or ST-segment depression were 72% to 77%. The corresponding cut-off points for percentage diameter stenosis were, respectively, 52% and 50% for patients with and without a stent (1.35 and 1.50 mm for minimal lumen diameter). We conclude that the presence of an intracoronary stent does not affect the diagnostic accuracy of recurrent angina or exercise-induced ST depression in predicting residual stenosis. We also conclude that exercise tolerance is similar after balloon angioplasty, with or without stenting, despite a better angiographic outcome in the group receiving a stent, suggesting a minimal threshold beyond which the patient is no longer at risk for ischemia during exercise. [less ▲]

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See detailCardiac Risk Assessment before Vascular Surgery: A Prospective Study Comparing Clinical Evaluation, Dobutamine Stress Echocardiography, and Dobutamine Tc-99m Sestamibi Tomoscintigraphy
VAN DAMME, Hendrik ULg; Pierard, Luc ULg; Gillain, Daniel ULg et al

in Cardiovascular Surgery (1997), 5(1), 54-64

Preoperative evaluation for cardiac risk assessment before peripheral vascular surgery remains controversial. Between January and June 1994, a prospective open study was carried out in 156 patients ... [more ▼]

Preoperative evaluation for cardiac risk assessment before peripheral vascular surgery remains controversial. Between January and June 1994, a prospective open study was carried out in 156 patients scheduled for elective vascular procedures (63 carotid endarterectomies, 34 abdominal aortic aneurysms, 29 aortoiliac and 30 infrainguinal reconstructions) to compare the ability of clinical data, dobutamine stress echocardiography, and dobutamine Tc-99m sestamibi tomoscintigraphy to predict postoperative cardiac events. Pharmacological stress testing consisted of incremental dobutamine infusion (+/-1 mg atropine to achieve 85% of age-predicted maximal heart rate, with continuous echocardiographic monitoring, and injection of Tc-99m sestamibi after dobutamine infusion). Dobutamine echocardiography was abnormal in 36 patients (worsening resting wall motion abnormality in 11; new induced wall motion abnormality in 25). Dobutamine Tc-99m sestamibi tomoscintigraphy revealed a reversible perfusion defect in 34 patients, indicating the presence of myocardial ischaemia. As a result, eight patients underwent myocardial revascularization (n = 5) or the proposed operation was cancelled (n = 3). In the remaining 142 vascular procedures, there were eight (5.6%) adverse cardiac events: three myocardial infarctions (two fatal), three prolonged myocardial ischaemia, one acute congestive heart failure and one sustained ventricular arrhythmia in the post operative period. Univariate analysis selected unstable angina (relative risk (RR) 11.6), previous congestive heart failure (RR 6.4), Detsky's score of > or = 15 (RR 3.0), positive dobutamine stress echocardiography (RR 3.7), and positive dobutamine tomoscintigraphy (RR 7.4) as significant predictors of postoperative cardiac events. In patients without clinical markers of coronary artery disease (n = 66), non-invasive cardiac testing did not predict cardiac complications (n = 2; one prolonged myocardial ischaemia; one infarction). In the subset of 76 patients with definite clinical or electrocardiographic evidence of ischaemic heart disease, dobutamine stress testing provided additional information, and optimized risk stratification: five of six patients who suffered a cardiac complication had a pathologic dobutamine stress test. Furthermore, a negative dobutamine stress test was characterized by a high negative predictive value (0.96 for echocardiography; 0.97 for tomoscintigraphy). The study further demonstrated that the cardiac response (ischaemic versus non-ischaemic) to dobutamine stress was concordantly classified by echocardiographic and tomoscintigraphic techniques in 96% of cases. It is concluded that complementary non-invasive cardiac stress testing by dobutamine is indicated only in patients with clinically apparent coronary artery disease. [less ▲]

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See detailMitogen-Activated Lymphocytes: A Good Model for Characterising Lung Cyp1a1 Inducibility
Lambert, Vincent ULg; Todaro, Anna ULg; Kremers, Pierre ULg et al

in European Journal of Epidemiology (1997), 13(2), 177-83

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility ... [more ▼]

The CYP1A1 hyperinducibility phenotype occurring in some 10% of the human population corresponds to a higher risk of developing lung cancer. This study was undertaken to assess whether the inducibility factor, generally evaluated on mitogen-activated lymphocytes after PAH induction, represents correctly the lung situation. Optimal experimental conditions were determined for evaluating, on both lymphocytes and lung tissue explants, the inducibility factor, defined as the ratio of EROD activity (CYP1A1-specific) to cytochrome c reductase activity (unaffected by PAH induction). Paired results for lymphocytes and lung tissue samples from 10 lung cancer patients were compared. A good correlation was observed between lymphocyte and lung tissue inducibilities (R = 0.809; p = 0.005). In conclusion, mitogen-activated lymphocyte inducibility is indicative of lung tissue inducibility and constitutes a good marker for evaluating individual PAH inducibilities. [less ▲]

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See detail"Pont a la transplantation" par ventricules pulsatiles de Pierce-Donachy (Thoratec)
Defraigne, Jean-Olivier ULg; DETRY, Olivier ULg; Chevolet, C. et al

in Revue Médicale de Liège (1997), 52(2), 110-5

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See detailPharma Clinics. Le médicament du mois. Le benzamycin, une actualisation du traitement topique de l'acné
Pierard, Gérald ULg

in Revue Médicale de Liège (1997), 52(2), 120-2

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See detailVers une chirurgie "supraconservatrice" des lésions mammaires infracliniques?
Lifrange, Eric ULg; Colin, Claude ULg

in Revue Médicale de Liège (1997), 52(2), 72-6

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See detailLocalization of Laminin, Fibronectin, E-Cadherin, and Integrins in Endometrium and Endometriosis
Beliard, Aude ULg; Donnez, J.; Nisolle, Michelle ULg et al

in Fertility and Sterility (1997), 67(2), 266-72

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study ... [more ▼]

OBJECTIVE: To compare the localization of adhesion proteins (laminin and fibronectin) and their receptors of the integrin family in endometriosis and endometrium. DESIGN: An immunohistochemical study. SETTING: University Hospital, Department of Gynecology and Department of Cell Biology. PATIENT(s): Eighteen endometriosis patients undergoing laparoscopy for pain or infertility and nine control patients undergoing laparoscopy for sterilization or hysterectomy. MAIN OUTCOME MEASURE(s): The expression of adhesion glycoproteins (laminin and fibronectin), their receptors alpha 1 beta 1, alpha 2 beta 1, alpha 3 beta 1, alpha 5 beta 1, and alpha 6 beta 1, and E-cadherin was determined by immunohistochemistry on frozen sections. RESULT(s): The distribution of both adhesive glycoproteins, laminin and fibronectin, and their receptors was identical in endometriosis and endometrium. Fibronectin receptors (alpha 4 beta 1, alpha 5 beta 1) displayed distinct expression patterns in endometrium and endometriosis. No endometrial glands showed positive staining for the alpha 5 chain, whereas this integrin subunit was detected in almost all endometriotic lesions. The integrin alpha 4 chain was present in all endometriotic glands but was absent from endometrial glands in the proliferative phase of the cycle. CONCLUSION(s): No difference in cell adhesion molecule localization nor receptors was observed between endometriotic and endometrial samples, except for fibronectin receptors. Their expression persisted around endometriotic glands but not in endometrium. These results suggest that fibronectin receptors could play a role in the persistence of endometriotic lesions, despite menstruation in corresponding eutopic endometrium. [less ▲]

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See detailEffet des protéines et des fibres alimentaires sur les pertes iléales d'acides aminés endogènes chez le porc.
Leterme, Pascal; Rossi, Florence; Thewis, André ULg

in Journées de la Recherche Porcine en France (1997), 29

An N-free diet was supplemented with limited but increasing amounts of proteins (30, 60, 90 g/kg diet from a mixture of casein and egg yolk), in order to measure their effect on the ileal endogenous amino ... [more ▼]

An N-free diet was supplemented with limited but increasing amounts of proteins (30, 60, 90 g/kg diet from a mixture of casein and egg yolk), in order to measure their effect on the ileal endogenous amino acid (AA) losses in pigs. The study was conducted at 2 dietary fibre levels: 20 and 80 g/kg, isolated from pea seeds. Compared to the N-free diet, a supply of 30 g proteins was sufficient to obtain a positive N retention and the following supplies allowed a constant and linear increase (0.88 g N retained/g N intake). The same supply induced an increase in ileal endogenous losses, compared to the control (10.7 vs 7.2 g AA/kg DMi for the low fibre diet) but the difference was not significant because of a high variability between the pigs. The supplies of 60 and 90 g proteins did not modify the level of the losses either: 10.2 and 10.6 g AA/kg DMi, respectively. The same trends were observed for the diets with a high fibre level but, in this case, the losses were significantly higher: respectively 14.9, 16.7, 15.7 and 17 g AA/kg DMi. On the other hand, the fraction of the digesta containing the free AA and the small peptides (< 3 kDa), supposed to be mainly of dietary origin, remained independent of the protein level. This suggests a virtually complete digestibility of the dietary proteins. Thus, pea fibres induce a significant increase of the ileal endogenous losses but without disturbing the protein digestion process, as suggested by the N retention. The protein supply probably increased the digestive secretions but the latter could have been highly reabsorbed, due to a lack in dietary factors susceptible to increase the reabsorption. [less ▲]

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See detailExpression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy.
Caron, Philippe; Buscail, Louis; Beckers, Albert ULg et al

in Journal of Clinical Endocrinology and Metabolism (1997), 82(11), 3771-3776

In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma ... [more ▼]

In pregnancy, the human placenta GH acts as a growth-promoting hormone and appears to be the main stimulator of insulin-like growth factor I (IGF-I) secretion. In a woman with a TSH-secreting macroadenoma, successful treatment with the somatostatin analog octreotide was conducted during the first month and the second half of pregnancy without side-effects on placental and fetal development. As observed in normal pregnancy, both serum placental GH and IGF-I levels increased throughout pregnancy and dropped sharply after delivery. In placental membranes from both treated and healthy untreated patients, we demonstrated the presence of high affinity binding sites for somatostatin-14 (Kd, 4.6 and 5.3 nmol/L; binding capacity, 1.53 and 1.35 pmol/mg protein, respectively). These receptors displayed low affinity for octreotide (IC50, 1.2-2 mumol/L), suggesting the presence of SST1 and/or SST4 receptors. We found that messenger ribonucleic acids of these two subtypes were expressed in both human placental tissue and purified human cytotrophoblast cells. Finally, the SST1-selective analog, des-AA1,2,5[D-Trp8,IAmp9]S-14 had low affinity for placental somatostatin receptors. These results argue in favor of the presence of the SST4 subtype in human placenta. At the doses administered, octreotide did not bind to placental somatostatin receptors. Our results may explain the absence of changes in both human placental GH and IGF-I concentrations that we observed during octreotide treatment. [less ▲]

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See detailLa dépense énergétique chez l'homme
Bustin, F.; Pestieau, S. R.; Paquot, Nicolas ULg et al

in Revue Médicale de Liège (1997), 52(2), 101-4

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See detailInterventional atrioseptostomy by application of monopolar high-frequency alternating current : In vitro evaluation of a new device.
Grabitz, R. G.; Handt, S.; Vanopbroeke, H. J. et al

in Investigative Radiology (1997), 32(2), 90-3

RATIONALE AND OBJECTIVES: The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with ... [more ▼]

RATIONALE AND OBJECTIVES: The authors evaluate the use of a new device for interventional creation of atrial septal defects (ASD) working with high-frequency alternating current in an in vitro study with porcine atria. METHODS: The device consists of a symmetrical cage of six superelastic monofile wires, including a microthermistor that is placed via a catheter into a punctured hole in the porcine foramen ovale. The device is used as a differential electrode for monopolar, temperature-controlled application of high-frequency alternating current for thermal modelling of ASD. RESULTS: Application of current for 60 seconds caused temperature-dependent, sized ASDs. CONCLUSION: In vivo animal studies to evaluate possible side effects and long term patency of the ASDs are justified and warranted. [less ▲]

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See detailEls problemes de la violència esportiva. 10 anys després de Heysel
Comeron, Manuel ULg; Van Limbergen, Kris

in Revista d’Historia L'Avenç (1997), (211), 25-32

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es ... [more ▼]

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es relaciona llavors amb comportaments d'agressio fisica i de vandalisme produïts pels espectadors d'una manifestacio esportiva, mes concretament dels partits de futbol. [less ▲]

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See detailPeyer's Patches in Murine Aids: Dissociation between Lymphoproliferation and Anergy
Colombi, S.; Moutschen, Michel ULg; de Leval, Laurence ULg et al

in Scandinavian Journal of Immunology (1997), 45(2), 175-81

RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches ... [more ▼]

RadLV-Rs infection induces a murine immunodeficiency syndrome associated with a dramatic enlargement of spleen and lymph nodes. Surprisingly, the lymphoproliferation excludes thymus and Peyer's patches (PP). To understand the cellular interactions underlying lymphoproliferation further, the authors investigated the fate of PP in RadLV-Rs infected mice. The atrophy of PP was mostly due to the depletion of B cells, while the proportion of CD4+ and CD8+ T cells was increased. Nevertheless, B cell phenotype was modified with the emergence of lymphocytes with a low expression of B220 in infected PP. T cells characterized by a memory/activated phenotype in control PP did not undergo phenotypical changes after viral infection (i.e. regarding Thy-1 and CD44 expression). Despite the absence of lymphoproliferation, PP T and B cells displayed altered responses to mitogens in vitro. Finally, alterations of the expression of adhesion molecules and vascular addressins could not explain the atrophy of PP by a reduced homing to this lymphoid site. B cells and T cells from normal PP are clearly different from lymph nodes (LN) lymphocytes. The authors propose that the particular functional state which characterizes PP lymphocytes influences the B cell/T cell crosstalk necessary for RadLV-Rs-induced lymphoproliferation. [less ▲]

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See detailComment je traite ... un melasma du visage
Pierard, Gérald ULg

in Revue Médicale de Liège (1997), 52(2), 58-9

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See detailClinical Neurophysiology of Headache
Schoenen, Jean ULg

in Neurologic Clinics (1997), 15(1), 85-105

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches ... [more ▼]

Methods of clinical neurophysiology are of little use for the diagnosis of headache disorders. They are, however, invaluable tools for a better understanding of the pathophysiology of functional headaches. They are traumatic, able to explore simple or more complex neural activities, and to some extent capable of reflecting activity in certain neurotransmitter systems as well as the action of pharmacologic agents on the CNS. This article reviews the interest and limits of electroencephalography, evoked potentials, electromyography, and nocifensive reflexes in primary headaches. Because neurophysiologic methods are no more than indirect means of looking into the "black box," their results need to be interpreted with caution and, whenever possible, should be compared in the same study with clinical behavioral and biochemical data. [less ▲]

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See detailThoracic sequelae after surgical closure of the patent ductus arteriosus in premature infants
SEGHAYE, Marie-Christine ULg; Grabitz, R.; Alzen, G. et al

in Acta Paediatrica (1997), 86(2), 213-6

Thirty-six children (median chronological age 6 years 1 month) who had undergone surgical closure of a patent ductus arteriosus through a left posterolateral thoracotomy in the neonatal period (median ... [more ▼]

Thirty-six children (median chronological age 6 years 1 month) who had undergone surgical closure of a patent ductus arteriosus through a left posterolateral thoracotomy in the neonatal period (median gestational age 32 weeks) were investigated prospectively with respect to anatomical and functional changes of the chest. At follow-up examination, residual or recurrent patent ductus arteriosus was not observed. Three patients had chronic bronchial obstruction. Two patients showed pathological musculoskeletal thoracic sequelae that did not require any treatment at the time of follow-up; persistence of immediate postoperative left phrenic palsy (n = 1) and thoracic scoliosis (n = 1). Twenty of the 27 patients in whom chest X-ray was performed had minor radiological skeletal anomalies in the form of rib deformation or fusion related to the thoracotomy, lesions which have a potential to induce thoracic scoliosis. Left shoulder elevation at chest X-ray and isolated left arm dysfunction at clinical examination were not observed. Despite the low incidence of scoliosis and the absence of left arm dysfunction observed at mid-term follow-up in our series, the incidence of minor rib deformations with a potential to induce severe anomalies such as scoliosis should motivate late follow-up examination at adolescence to definitively assess the prevalence of thoracic sequelae after surgical closure of the patent ductus arteriosus in premature infants. [less ▲]

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See detailAnionic polymerization of primary acrylates as promoted by Lithium 2-(2-Methoxyethoxy) ethoxide
Nugay, Nihan; Nugay, Turgut; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(2), 361-369

Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an ... [more ▼]

Some primary acrylates, such as methyl, ethyl, n-butyl, and n-nonyl acrylate (MA, EA, nBuA and nNonA, respectively) have been anionically polymerized by using diphenylmethyl lithium (DPMLi) as an initiator, in the presence of a chelating - dual ligand, i.e., a polydentate lithium alkoxide, at low temperature. It has been found that lithium 2-(2-methoxyethoxy) ethoxide (LiOEEM) is a very efficient ligand in preventing the anionic polymerization of these monomers from being disturbed by significant secondary transfer and termination reactions. Even for the difficult cases of ethyl and methylacrylate, that approach provides high polymerization yields and low polydispersity, allowing the molecular weight to be predetermined. LiOEEM/initiator molar ratio, solvent polarity, temperature and monomer concentration have proved to be key parameters in the control of the polymerization process. The efficiency of that control is however dependent on the monomer structure and improves with the length of the n-alkyl substituent, i.e., MA < EA < nBuA < nNonA. [less ▲]

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See detailSynthesis and characterization of biodegradable homopolymers and block copolymers based on adipic anhydride
Ropson, Nathalie; Dubois, Philippe ULg; Jérôme, Robert ULg et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(1), 183-192

Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in ... [more ▼]

Homopolymers of adipic anhydride (AA) and block copolymers of -caprolactone (-CL) and AA have been synthesized with aluminum triisopropoxide as an initiator. Homopolymerization was studied at 20°C in toluene and methylene chloride (CH2Cl2). The end-group analysis agrees with a coordination insertion mechanism based on the acyl-oxygen cleavage of the AA ring. Living poly(-caprolactone) (PCL) chains are very efficient macro-initiators for the polymerization of AA, with formation of diblock copolymers of a narrow molecular weight distribution. At our best knowledge, low molecular weight -aluminum alkoxide PCL macroinitiators (M¯n < 1000) allow the first valuable synthesis of PAA with a molecular weight as high as 58,000 and a quite narrow polydispersity (M¯w/M¯n = 1.2). Size-exclusion chromatography (SEC) and 13C NMR confirm the blocky structure of the copolymers, in agreement with DSC that shows two melting endotherms and two glass transitions characteristic of the crystalline and amorphous phases of PCL and PAA, respectively. Block copolymers of c-CL and AA are also sensitive to hydrolysis, which makes them possible candidates for biomedical applications. Initiation of the AA polymerization in bulk with aluminum triisopropoxide in the presence of various ligands is also discussed. [less ▲]

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See detailLiving Anionic Homopolymerization and Block Copolymerization of 4-Vinylpyridine at "Elevated" Temperature and Its Characterization by Size Exclusion Chromatography
Creutz, Serge; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(1), 1-5

The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert ... [more ▼]

The anionic polymerization of 4-vinylpyridine (4VP) has been investigated in 9/1 pyridine/THF at 0 °C. After characterization of the living character of 4VP polymerization, its copolymerization with tert-butyl methacrylate (tBMA) has been carried out also successfully. Their relative reactivity ratios have been determined. Solvent composition as well as temperature have been varied in order to evaluate their influence on the final molecular characteristics of the polymers. Finally, a new SEC methodology in 8/1/1 N,N-dimethylformamide/triethylamine/pyridine has been developed. [less ▲]

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See detailLiving Anionic Homopolymerization and Block Copolymerization of (Dimethylamino)ethyl Methacrylate
Creutz, Serge; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1997), 30(1), 6-9

Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow ... [more ▼]

Anionic polymerization of (dimethylamino)ethyl methacrylate (DMAEMA) has been investigated in THF at -78°C. The presence of lithium chloride has been shown to be desirable in order to afford a narrow molecular weight distribution as well as a good agreement between theoretical and observed molecular weight. The living character of the polymerization has been demonstrated. Thus the synthesis of block copolymers, some of them unattainable by GTP, has been carried out successfully. Finally, the anionic polymerization of mixtures of tert-butyl methacrylate (tBMA) and DMAEMA has been considered and their relative reactivity ratio estimated. The easy quaternization of (dimethylamino)ethyl methacrylate affords amphiphilic water-soluble copolymers displaying interesting characteristics as polymeric dispersants and surfactants. [less ▲]

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See detailAn updated model of the hot nitrogen atom kinetics and thermospheric nitric oxide
Gérard, Jean-Claude ULg; Bisikalo, D. V.; Shematovich, V. I. et al

in Journal of Geophysical Research (1997), 102

New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom ... [more ▼]

New observations and reanalysis of previous measurements suggest an upward revision of the measured thermospheric nitric oxide density. Our previous model of NO production by fast N([SUP]4[/SUP]S) atom collisions with O[SUB]2[/SUB] has been updated. It includes the effect of soft solar X rays, Auger electrons, and a detailed treatment of N[SUB]2[/SUB] dissociative ionization channels. In addition, new calculations indicate that the transfer of translational energy in N+N[SUB]2[/SUB] collisions is less efficient than in the hard sphere approximation. This result leads to reevaluation of the energy dependent relaxation cross section and to an upward revision of the reacting efficiency of collisions of N with O[SUB]2[/SUB] to form nitric oxide. The calculated peak NO density increases by a factor of ~2 when the effect of superthermal nitrogen atoms is included. The model response of the N([SUP]4[/SUP]S) energy distribution function and NO density to solar cycle variations is presented. The NO density at 110 km changes from 5.4×10[SUP]7[/SUP] to 1.3×10[SUP]8[/SUP]cm[SUP]-3[/SUP] when the solar F[SUB]10.7[/SUB] index varies from 70 to 245, but its response depends on the magnitude of the soft X ray increase with solar activity. [less ▲]

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See detailFourth supplement to the catalogue of observed periods of Ap stars
Catalano, F. A.; Renson, Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1997), 121

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before ... [more ▼]

New data on the periods of Ap stars with references are presented (Table 1). 21 further stars are introduced for which a periodic variability has recently been discovered or for which it was known before but it was not reported in previous issues of this catalogue. For many stars also present in previous issues of the catalogue new determinations of the periods are given. Recently attributed variable star names are also quoted. Table 1, notes to this Table and related references are only available in LaTEX form at the CDS via anonymous ftp 130.79.128.5 (filename: DS1178.tex). [less ▲]

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See detailDifferent universality classes for SOC in models driven by extremal dynamics
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Europhysics Letters [=EPL] (1997), 37(1), 1-6

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree ... [more ▼]

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree-like model does not seem to belong to any already studied SOC universality class. This is shown through a discussion of the dynamics and the so-called gap equation which does not hold here. [less ▲]

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See detailIncrease in Cytokine Production (Il-1 Beta, Il-6, Tnf-Alpha but Not Ifn-Gamma, Gm-Csf or Lif) by Stimulated Whole Blood Cells in Postmenopausal Osteoporosis
Zheng, S. X.; Vrindts-Gevaert, Yvonne; Lopez, Marie-Josée ULg et al

in Maturitas (1997), 26(1), 63-71

Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms ... [more ▼]

Postmenopausal osteoporosis is a progressive disorder characterized by a decreased bone mass and increased susceptibility to fractures. Several investigations have suggested that one of the mechanisms through which estrogen prevents bone loss was a modulation on secretion or release of various cytokines that are known to influence bone remodeling, even if some recent data have challenged this hypothesis. However, in established osteoporosis, the possibility that enhanced cytokines activity may account for the progression of this disease remains unclear and controversial. We sought here to determine whether production of IL-1 beta, IL-6, TNF-alpha, IFN-gamma, GM-CSF and LIF, after direct stimulation in whole blood, was different in healthy (n = 30) or osteoporotic postmenopausal women (n = 24) and whether lumbar bone density (1-BMD) correlated with the values of cytokine production observed in these conditions. A significant difference was observed between the osteoporotic and control subjects for IL-1 beta (p < 0.0001), IL-6 (p < 0.001) and TNF-alpha (p = 0.027) productions, the values being higher in the osteoporotic women. No significant differences between the groups were observed for IFN-gamma (p = 0.51), GM-CSF (p = 0.70) or LIF (p = 0.97). In the whole population, statistically significant negative correlations were observed between lumbar BMD and IL-1 beta (r = -0.46) (p < 0.0005), IL-6 (r = -0.50) (p < 0.0001) and TNF-alpha (r = -0.39) (p < 0.005) production while no such correlations were observed for IFN-gamma, GM-CSF or LIF. In conclusion, the study of cytokine production by immune cells cultured in autologous whole blood suggests that in women more than 10 years past the menopause and presenting a decrease in lumbar bone density corresponding to the new WHO definition of "osteoporosis', production of IL-1 beta, IL-6 and TNF-alpha is still increased compared to controls matched for age and ovarian function, while no differences are reported for IFN-gamma, GM-CSF or LIF production. [less ▲]

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See detailElevated Plasma Alpha 1-Acid Glycoprotein Levels: Lack of Connection to Resistance to Vecuronium Blockade Induced by Anticonvulsant Therapy
Hans, Pol ULg; Brichant, Jean-François ULg; Pieron, F. et al

in Journal of Neurosurgical Anesthesiology (1997), 9(1), 3-7

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled ... [more ▼]

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled for routine neurosurgery were included in the study. The patients were treated (TG; n = 20) with phenytoin (n = 15) and/or carbamazepine (n = 4) and/or phenobarbital (n = 3) for > or = 6 days or were left untreated (UG; n = 11, control group). TG patients were further assigned to one of two subgroups according to the plasma anticonvulsant level measured the day before surgery and found to be within (TGW, n = 10) or below (TGB, n = 10) the therapeutic range. Finally, the 31 patients were divided into two more groups according to their plasma AAG levels: higher than (HAAG, n = 17) or within (NAAG, n = 14) the normal range (25-94 mg dl-1). Anesthesia was induced and maintained with propofol and sufentanil. Muscle relaxation was obtained with vecuronium 0.1 mg kg-1. A train-of-four (TOF) stimulation mode at 2 Hz was applied to the ulnar nerve every 15 s, and neuromuscular transmission was assessed using a TOF-Guard accelograph monitor. Plasma AAG concentrations (means +/- SEM) were 103.7 +/- 7.6 mg dl-1 in TG, 80.7 +/- 6.7 mg dl-1 in UG, 95.9 +/- 13.2 mg dl-1 in TGW, 111.6 +/- 7.6 mg dl-1 in TGB. 114.9 +/- 7.4 mg dl-1 in HAAG, and 71.4 +/- 3.8 mg dl-1 in NAAG groups. The differences in plasma AAG concentrations between UG and TG and between HAAG and NAAG groups were statistically significant. No significant relationship was found between plasma AAG levels and phenytoin concentrations (r = -0.26). The time (mean +/- SEM) to recovery of T1 to 25% of control was significantly shorter in TG (28.2 +/- 1.4 min) than in UG (42.2 +/- 3.1 min) but did not differ significantly according to the plasma anticonvulsant level (27.3 +/- 2.0 min in TGW; 29.1 +/- 1.9 min in TGB) and the plasma AAG level 31.7 +/- 1.9 min in HAAG; 35.3 +/- 3.3 min in NAAG). The time for the TOF ratio to recover to 25% yielded similar profiles and statistical significance levels: TG, 32.9 +/- 2.2 min; UG, 51.2 +/- 4.0 min; TGW, 35.0 +/- 3.9 min; TGB, 30.7 +/- 1.8 min; HAAG, 38.1 +/- 3.1 min; NAAG, 42.0 +/- 4.1 min. We conclude that anticonvulsant therapy induces an increase in plasma AAG independently of the plasma anticonvulsant level. However, duration and recovery of vecuronium blockade do not differ according to plasma AAG levels. Consequently, elevated AAG does not contribute to the resistance to vecuronium blockade induced by anticonvulsants. [less ▲]

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See detailLiving free radical polymerization of macromonomers: preparation of well defined graft copolymers
Hawker, Craig Jon; Mecerreyes, David; Elce, Edmund et al

in Macromolecular Chemistry and Physics (1997), 198(1), 155-166

Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was ... [more ▼]

Well defined graft copolymers have been synthesized by a nitroxide-mediated "living" free radical process using pre-formed macromonomers. Analysis of the graft systems revealed that the macromonomer was efficiently incorporated into the polymeric back-bone to give block copolymers of controlled molecular weight and narrow polydispersi-ties. An added benefit of the "living" free radical process is that macromonomers, such as polylactide or polycaprolactone, which contain reactive functional groups can be used to form novel graft Systems using this approach. Functionalized monomers or polymeric initiators were also used in the copolymerization mixture to give graft Systems with a variety of functional groups attached to the backbone. [less ▲]

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See detailLes Banyarwanda du Sud-Kivu: les Banyamulenge?
Kabamba, Bob ULg

in Revue Nouvelle (1997), (n°1), 7-15

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See detailGeometric and healing laws in simple stochastic models of fracture in a sputtering process
Dhulst, R.; Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 55(1), 189-193

We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992 ... [more ▼]

We investigated two simple models of two-dimensional square lattice fracture under sputtering process conditions extending a previously studied model by Ausloos and Kowalski [Phys. Rev. B 45, 12 830 (1992)]. The models differ by the particle displacement rules during the fracture. Healing of the medium is observed in both models. This effect implies the formation of several thresholds during sputtering process fracture. They are distributed as a size-dependent power law. An avalanche like exponent is also obtained. We study this phenomenology within scaling arguments of classical percolation theory and mean-field arguments. [less ▲]

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See detailExpression of Bone Matrix Proteins in Human Breast Cancer: Potential Roles in Microcalcification Formation and in the Genesis of Bone Metastases
Bellahcene, Akeila ULg; Castronovo, Vincenzo ULg

in Bulletin du Cancer (1997), 84(1), 17-24

The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high ... [more ▼]

The skeleton is the privileged target of metastatic human breast cancer cells. Bone metastases are indeed found in virtually all advanced breast cancer patients and generate major morbidity. The high osteotropism of breast cancer cells suggests that they exhibit a selective affinity for mineralized tissues. The observation that mammary malignant cells are able to induce hydroxyapatite crystals deposition within the primary tumour suggests that they can generate a microenvironment that favors the crystallization of calcium and phosphate ions into the bone specific hydroxyapatite. Osteonectin (OSN), osteopontin (OPN) and bone sialoprotein (BSP), 3 bone matrix proteins involved in bone matrix mineralization, are expressed in human breast cancers. BSP, an RGD (Arg-Gly-Asp) containing phosphoprotein, initiates hydroxyapatite deposition and mediates attachment of osteoclast to the same crystals prior to their resorption. Detection of BSP at both the protein and the mRNA levels in human breast cancer and in human breast cancer cell lines (MCF-7, T47-D and MDA-MB 231) indicates that mammary malignant cells synthesize directly BSP rather than uptaking it from the serum. Interestingly, the level of BSP expression correlates with the development of bone metastases and with poor survival. These data suggest that the ectopic expression of bone matrix proteins could be involved in conferring osteotropic properties to circulating metastatic breast cancer cells. These observations open new alleys of investigation for the identification of the molecular mechanisms responsible for the genesis of bone metastases. [less ▲]

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See detailMiscellaneous and Experimental Agents
Reginster, Jean-Yves ULg

in American Journal of the Medical Sciences (The) (1997), 313(1), 33-40

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally ... [more ▼]

Current therapeutic approaches to postmenopausal bone loss or established osteoporosis vary widely among the different regions of the world. Because no treatment of osteoporosis has unequivocally demonstrated full prevention of the appearance or the recurrence of axial or peripheral fractures so far, many investigational compounds are being developed. Anabolic steroids act mainly as inhibitors of bone resorption with very few, if any, effects on bone formation. Because of the high occurrence of signs of virilization and the weak effects on bone structure, the risk/benefit ratio in osteoporosis should be considered at least problematic. If ongoing large-scale trials confirm the expected benefits of estrogen antagonist/agonists on the skeleton and confirm no cardiovascular risk to postmenopausal women with optimal uterine safety, these substances are likely to become the most prominent alternative to hormonal replacement therapy after the menopause. Additional studies are requested to evaluate the potential benefit of growth hormone or insulin-like growth factors in treatment of osteoporosis. Ipriflavone acts predominantly as an inhibitor of bone resorption. To confirm the efficacy of ipriflavone on the prevention of vertebral fractures and its effects on bone mineral density in women with postmenopausal established osteoporosis, a large multicentric European study is being conducted. Treatment with parathyroid peptides induces a significant gain in bone mass, mainly in the axial skeleton. Long-term studies that compare peptides, doses, and regimes are needed to better understand the exact position of parathyroid peptides as treatment of osteoporosis. Prolonged administration of strontium to postmenopausal osteoporotic women resulted in a decoupling between bone resorption and formation that yielded a significant increase in the lumbar spine bone mineral density of treated subjects. In the view of these promising results and of the excellent tolerance of strontium during preliminary trials, additional investigations of this compound in prevention and treatment of osteoporosis should be promptly initiated. Several other compounds have been punctually suggested for treatment of osteoporosis or are at very early stages of development. Finally, besides pharmacologic approaches to the treatment of osteoporosis, hip fractures may also be reduced by the use of hip protectors. [less ▲]

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See detailTriblock copolymer based thermoreversible gels. 1. Self-association of sPMMA end-blocks in o-xylene and viscoelasticity of the gels
Yu, Jian Ming; Jérôme, Robert ULg; Teyssié, Philippe

in Polymer (1997), 38(2), 347-354

Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block ... [more ▼]

Syndiotactic poly(methyl methacrylate) (sPMMA)-polybutadiene (PBD)-sPMMA triblock copolymers, or MBM, have been studied in the presence of o-xylene which is a selective solvent for the central PBD block. Syndiotactic PMMA is known to self associate in o-xylene. The central PBD sequence does not prevent the self-association of sPMMA from occurring. Actually, this phenomenon contributes to the stability of the gels formed at room temperature. An endotherm is observed at 35°C, which is responsible for a gel-sol transition. The original solutions have been heated up to 80°C and then rapidly cooled down below 35°C and maintained at 10, 20 and 25°C respectively. The self-association of the sPMMA outer blocks, and thus the liquid-solid transition, have been studied at each of these temperatures. Dependence of the gel viscosity on frequency and temperature effects on viscoelasticity has also been investigated. [less ▲]

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See detailConstruction and properties of fractal trees with tunable dimension: The interplay of geometry and physics
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Physical Review E (1997), 55(1), 94-98

In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches ... [more ▼]

In this paper, we emphasize three different techniques for the growth of fractal trees with a desired fractal dimension D-f. The three different growths are due to the influence of (i) stretched branches, (ii) dead ends, or (iii) a variable branching rate. Several examples are given. We point out that geometrical and physical properties (skeleton dimension, percolation exponents, self-avoiding walk) of fractal tress depend strongly on their type. The most striking result is that the critical exponents at the percolation transition are nonuniversal since they depend on the tree type. The critical exponents depend on D-f for trees of types (ii) and (iii). [less ▲]

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See detailCytotoxic interactions of 5-fluorouracil and nucleoside analogues in vitro
Li, Y-X; COUCKE, Philippe ULg; Paschoud, N et al

in Anticancer Research (1997), 17(1A), 21-27

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3 ... [more ▼]

The cytotoxic interaction of combined 5-fluorouracil (5-FU) with different nucleoside analogues was investigated in vitro on a colon (WiDr) and a breast (MCF-7) cancer cell line. Azidothymidine (AZT), 3'-deoxy-2', 3'-didehydrothymidine (D4T), 5-iododeoxyuridine (IdUrd) and 2',3'-dideoxycytidine (DDC) were tested at different concentrations (5-600 microM) as modulators of 5-FU. The experimental endpoints were cellular viability and cell cycle distribution. The combination of 5-FU and AZT or D4T yielded supra-additive cytotoxic effects in both cell lines at all concentrations. On WiDr, IdUrd at high concentrations of 50 and 100 microM showed a supra-additive effect whereas at low concentrations (5, 10 and 20 microM) the effect was antagonistic. 5-FU combined with IdUrd produced a synergistic effect on MCF-7 cells at all concentrations. DDC antagonised the toxic effect of 5-FU on the WiDr cell line. In WiDr cells, a significant increase in the overall S-phase was observed 48 and 72 hours after exposure to D4T, AZT and DDC at the low concentration of 10 microM. On the contrary, this accumulation in S-phase was not present in MCF-7 cells. The combined effect of 5-FU and nucleoside analogues in vitro is dependent on the type and concentration of nucleosides and the cell-line tested. AZT, D4T and IdUrd are more likely to be subjected to more intensive in vitro and in vivo research as far as modulation of 5-FU toxicity is concerned. [less ▲]

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See detailStereotaxic Needle-Core Biopsy and Fine-Needle Aspiration Biopsy in the Diagnosis of Nonpalpable Breast Lesions: Controversies and Future Prospects
Lifrange, Eric ULg; Kridelka, Frédéric ULg; Colin, Claude ULg

in European Journal of Radiology (1997), 24(1), 39-47

OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special ... [more ▼]

OBJECTIVE: To determine the advantages and limitations of a combined stereotaxic fine-needle aspiration biopsy and needle-core biopsy in the diagnosis of 353 nonpalpable breast lesions with special attention given to the collection of follow-up data. METHODS AND MATERIAL: 353 nonpalpable breast lesions underwent 'one pass' stereotaxic fine-needle aspiration (21 gauge needle) and needle-core biopsy (18 gauge needle) at our institution from January 1990 to October 1993. Stereotaxic biopsies were carried out by means of an 'add-on unit'. Surgical biopsy was usually recommended for highly suspicious radiologic patterns and/or needle biopsy reports classified as atypical or malignant. In all other cases mammographic follow-up was advised at 6 months and then annually for 3 years. The data were collected retrospectively during September 1995 (theoretical average follow-up of greater than 3 years). RESULTS: Following the combined needle biopsy technique procedure, surgery was recommended for 83 lesions. Fifty-four cancers were associated to these suspicious lesions. Because of changing radiological or clinical pattern during follow-up (mean follow-up: 22 months), 11 cancers were detected among the 270 lesions initially considered not to need surgery. Forty-three percent of the 65 malignant lesions were initially read as having less than highly suspicious mammographic features. There was no significant difference between the sensitivity and the specificity of one pass fine-needle aspiration biopsy (57% and 96% respectively) and needle-core biopsy (60% and 97% respectively), but noncontributive samples were not included in the false negative diagnoses and atypical samples were included in the true positive diagnoses. Of the 11 missed cancers, nine were manifested initially by clusters of calcifications. Our diagnostic approach was significantly less sensitive (P = 0.006) and less specific (P = 0.032) in cases of clusters of calcifications (31% false negative diagnoses) than in cases of soft-tissue masses (5.5% false negative diagnoses). In this study, an average delay in diagnoses of 22 months was responsible for a significantly increased percentage of axillary node positive invasive cancer (P < 0.001) and six of the 11 missed cancers were palpable at the time of the delayed diagnosis. For the nine cancers initially manifested by calcifications, the 22 months delay in diagnosis was responsible for a nonsignificant increase of microinvasive type at the expense of carcinoma in situ. CONCLUSION: Our enthusiasm with the sensitivity of this double stereotaxic needle sampling has been tempered by the results of this reanalysis in the light of a mean theoretical follow-up of three years. Our diagnostic approach was adequate in the presence of soft-tissue masses but not valid in the presence of clustered calcifications. When dealing with calcifications, multiple samplings must be done in order to improve the sensitivity of the diagnosis. Furthermore, this study does not favour the theory that the majority of mammographically detected cancers are indolent and highlights the poor sensitivity of the mammographic follow-up of nonpalpable lesions. [less ▲]

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See detailCalcitonine et vieillissement osseux
Reginster, Jean-Yves ULg

in Pathologie Biologie (1997), 45(1), 52-6

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that ... [more ▼]

There appears to be a consensus that 100 IU/day of nasally administered salmon calcitonin may prevent trabecular bone loss during the first years of the menopause. Strong evidence exists that half that dose may also be sufficient to prevent trabecular bone loss and that higher doses (> or = 200 IU/day) induce a significant increase in spinal bone mineral content. Calcium supplements should be systemically administered when calcitonin is given, particularly at high doses. Rectal calcitonin seems also to be an efficient alternative in prevention of trabecular bone loss. Further studies are required to evaluate the effect of calcitonin in prevention of cortical bone loss. In established osteoporosis, calcitonin may prevent further bone loss at trabecular and cortical sites. A similar benefit is obtained following parenteral or nasal administration of the drug. Long-term administration of nasal salmon calcitonin induces a significant dose-dependent gain of bone at the lumbar spine, whereas discontinuous therapy with a ratio of 1:2 or 2:3 between the treatment and nontreatment periods is the best regimen for cortical bone. Epidemiological, retrospective, and prospective studies provide a convergent network of evidence that calcitonin administration in osteoporosis contributes to reduce significantly the frequency of subsequent fractures, both in the spine and in the hip. Finally, in established osteoporosis, nasal calcitonin possesses a potent analgesic effect, reduces the duration of bed confinement, and decreases the number of concomitant analgesic medications. The well-demonstrated effects of nasal calcitonin permit it to be considered as a highly rational solution for the prevention and the treatment of postmenopausal osteoporosis. [less ▲]

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See detailAnalysis of Equine Scintigraphical Lung Images
Votion, Dominique ULg; Vandenput, Sandrina ULg; Duvivier, H. et al

in Veterinary Journal (1997), 153(1), 49-61

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to ... [more ▼]

A method is proposed (1) to create inhalation to perfusion ratio (I/Q) images from equine lung scintiscans and (2) to analyse these I/Q images. This method was applied to five healthy horses in order to establish reference ranges of I/Q distribution pattern. Computed I/Q images were divided in three regions based on the activity due to the inhalation (I) versus perfusion (Q) procedure. For each region a regional mismatching factor (Iri), i.e. the I/Q of the region, and an intraregional mismatching factor (Lri), which expresses the variability of pixels' I/Q within the region, were calculated. The Per(Ri) and Cen(Ri), which are the percentage of pixels in the parenchymal and in the central parts of the lung belonging to the region, were also computed. Results of this analysis showed a good match between I and Q distribution pattern. [less ▲]

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See detailStreptococcus difficile Is a Nonhemolytic Group B, Type Ib Streptococcus
Vandamme, Peter; Devriese, L. A.; Pot, B. et al

in International Journal of Systematic Bacteriology (1997), 47(1), 81-5

Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG ... [more ▼]

Whole-cell protein electrophoretic analysis of the type strain of Streptococcus difficile (LMG 15799) revealed that this organism was indistinguishable from Streptococcus agalactiae strains. Although LMG 15799'r (T = type strain) was originally described as serologically untypeable, we found that this strain was a group B streptococcus belonging to the capsular polysaccharide antigen type Ib group. The biochemical reactivity of S.difficile, which differed from the biochemical reactivity of typical S. agalactiae strains mainly by being less versatile, is similar to the biochemical reactivity of other group B, type Ib streptococci isolated from poikilothermic animals, such as fish and frogs. [less ▲]

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See detailAccident vasculaire cérébral et thrombus aortique chez un patient déficient en protéine S
Lambermont, Bernard ULg; Ghuysen, Alexandre ULg; Marcelle, Roland ULg et al

in Archives des Maladies du Coeur et des Vaisseaux (1997), 90(1), 99-102

The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery ... [more ▼]

The authors report the case of a 50 year old man admitted to hospital with a right hemiplegia and aphasia of sudden onset in whom embolic fragments were found in the left mid and anterior cerebral artery territories at left carotid angiography : transoesophageal echocardiography demonstrated a protrusive plaque of atherosclerosis in the ascending aorta and a pediculated thrombosis in the descending aorta. Biological investigations revealed a protein S level of 3% (normal : 70-140%). This case illustrates the acute development of a thromboembolic phenomenon originating from the aortic arch in a patient with a coagulation defect. [less ▲]

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See detailGeografia, storia e poetiche del fantastico.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailLa tertiarisation des parcs d’activités économiques en Région wallonne
Devillet, Guénaël ULg

in Wallonie (1997), 24(49), 35-44

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See detailTowards interbreed IBD fine mapping of the mh locus: double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed.
Dunner, S.; Charlier, Carole ULg; Farnir, Frédéric ULg et al

in Mammalian Genome : Official Journal of the International Mammalian Genome Society (1997), 8(6), 430-5

The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis ... [more ▼]

The Spanish "Asturiana" cattle breed is characterized by the segregation of a genetically determined muscular hypertrophy referred to as double-muscling or "culones". We demonstrate by linkage analysis that this muscular hypertrophy involves the mh locus previously shown to cause double-muscling in the Belgian Blue cattle breed, pointing towards locus homogeneity of this trait across both breeds. Moreover, using a twopoint and multipoint maximum likelihood approach, we show that flanking microsatellite markers are in linkage disequilibrium with the mh locus in both breeds albeit with different alleles. Finally, we discuss how allelic homogeneity across breeds might be exploited to achieve efficient genetic fine-mapping of the mh locus. [less ▲]

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See detailLa responsabilité civile et professionnelle des administrateurs
Caprasse, Olivier ULg

in Actualités du Droit (1997)

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See detailL'hypoglycemie du patient diabetique. Recommendations of ALFEDIAM (French Language Association for the Study of Diabetes and Metabolic Diseases.
Grimaldi, A.; Slama, G.; Tubiana-Rufi, N. et al

in Diabètes & Métabolism (1997), 23(1), 100-8

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See detailEtat de nécessité et damnum incendii arcendi causa datum
Gerkens, Jean-François ULg

in Revue Internationale des Droits de l'Antiquité (1997), 44

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See detailRésultats à une enquête internationale en mathématiques
Monseur, Christian ULg

in Mathématiques & pédagogie (1997), 114

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See detailL'article 185, alinéa 2, du Code civil et les opérations sur titres
Partsch, Philippe-Emmanuel ULg

in Revue Pratique des Sociétés (1997)

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See detailOn the use of HF as a reference for the comparison of stratospheric observations and models
Chipperfield, M. P.; Burton, M.; Bell, W. et al

in Journal of Geophysical Research (1997), 102(11D), 12901-12919

Hydrogen fluoride (HF) is often used as a simple reference for other column observations of chemically active stratospheric species. However, seasonal and shorter timescale variations in column HF make ... [more ▼]

Hydrogen fluoride (HF) is often used as a simple reference for other column observations of chemically active stratospheric species. However, seasonal and shorter timescale variations in column HF make its use as a reference more complicated. In this paper we characterize the expected magnitude of these variations in HF, and variations of ratio quantities involving HF, using a two-dimensional (2-D) photochemical model and two versions of a three-dimensional (3-D) transport model. The 2-D model predicts that the column ratios HNO3/HF and HCl/HF increase from midlatitudes to the tropics, although this is very sensitive to HCl and HNO3 abundances in the tropical upper troposphere. Seasonal variations in vertical motion modifys the predicted ratios; for example, wintertime descent at high latitudes decreases HCl/HF. The ratio HNO3/HF at high latitudes is strongly modified by seasonal variations in the chemical partitioning of the odd nitrogen (NOy) species. We compare these model predictions with ground-based Fourier transform infrared spectroscopy (FTIR) observations of HF along with HCl, ClONO2 and HNO3 obtained at eight northern hemisphere sites between October 1994 and July 1995. We investigate quantitatively how HF can be used as a tracer to follow the evolution of observations at a single station and to intercompare results from different stations or with photochemical models. The magnitude of the 3-D model HF column agrees well with the observations, except on some occasions at high latitudes, giving indirect support for the important role of COF2 in the stratospheric inorganic fluorine budget. The observed day-to-day variability in the column ratios HCl/HF and HNO3/HF is much larger at high latitudes. This variability is reproduced in the 3-D models and is due to horizontal motion. Short timescale vertical displacement of the species profiles is estimated to have a small effect on the column ratios. In particular, we analyze the usefulness of the observed column ratio (ClONO2 + HCl)/HF as an indicator for chlorine activation. Current measurement uncertainties limit the degree of activation which can be unambiguously detected using this observed quantity, but we can determine that chlorine-activated air was observed above Aberdeen (58 degrees N) on 6 days in late January 1995. [less ▲]

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See detailDilatometric and calorimetric study of the graphitisation of high chromium cast iron
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Bojinov, V. et al

in Journal de Chimie Physique et de Physico-Chimie Biologique (1997), 94[5]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements ... [more ▼]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements thermiques adaptés. La solidification de la fonte étudiée a été examinée par analyse thermique différentielle (ATD). Les effets d'un traitement à haute température ont été examinés à la fois par calorimétrie et dilatomètre différentielle. Le graphite primaire se forme vers 950°C. Le graphite secondaire précipite sur le graphite primaire lors du traitement de déstabilisation de l'austénite à haute température. La forme et la quantité de graphite secondaire dépendent de la température de traitement. [less ▲]

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See detailUltrasonographic examination of the proximal scutum in the horse.
Denoix, J. M.; Busoni, Valeria ULg; Olalla, M. J.

in Equine Veterinary Journal (1997), 29(2), 136-41

Normal and abnormal ultrasonographic images are presented of the proximal scutum (proximal sesamoid bones and palmar ligament) in the horse. Comparison between anatomical sections, MRI (magnetic resonance ... [more ▼]

Normal and abnormal ultrasonographic images are presented of the proximal scutum (proximal sesamoid bones and palmar ligament) in the horse. Comparison between anatomical sections, MRI (magnetic resonance imaging) and ultrasound scans enabled the authors to establish the normal ultrasonographic anatomy of the palmar fetlock. Nine cases of proximal scutum injuries were identified ultrasonographically, of which 4 are illustrated. On normal limbs, the facies flexoria of the proximal sesamoid bones appeared as a thin and regular hyperechoic line and the palmar ligament was regularly echogenic. Lesions of the proximal scutum, that could be documented ultrasonographically, included rupture of the palmar ligament, avulsion fractures of the proximal sesamoid bones and palmar ligament desmopathy. Thinning or degeneration of the palmar ligament, concurrent with osteolysis of the proximal sesamoid bones, were indicative of palmar ligament enthesopathy. Ultrasonographic examination provided essential information for an accurate diagnosis of proximal scutum damage. [less ▲]

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See detailLes hermeneis dans le christianisme primitif. Aux sources du schisme byzantin
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1997), 67

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See detailPeptides in membranes: tipping the balance of membrane stability.
Brasseur, Robert ULg; Pillot, T.; Lins, Laurence ULg et al

in Trends in biochemical sciences (1997), 22(5), 167-71

This review describes a class of peptides that associate with lipids in membranes and are commonly known as 'oblique-orientated peptides'. Owing to an asymmetric distribution of hydrophobic residues along ... [more ▼]

This review describes a class of peptides that associate with lipids in membranes and are commonly known as 'oblique-orientated peptides'. Owing to an asymmetric distribution of hydrophobic residues along the axis of the alpha-helix, such peptides can destabilize membranes or lipid cores, thereby facilitating such cellular processes as vesicular fusion or protein transport across subcellular compartments, as well as remodelling of lipid cores. [less ▲]

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See detailGravitational lensing by damped Ly-alpha absorbers
Smette, Alain; Claeskens, Jean-François ULg; Surdej, Jean ULg

in New Astronomy (1997), 2

Assuming that (i) damped Ly-alpha absorbers (DLAs) arise in present-day-like spiral galaxies which are immersed in isothermal dark matter halos, (ii) that these galaxies obey the Tully-Fisher sigma/sigma ... [more ▼]

Assuming that (i) damped Ly-alpha absorbers (DLAs) arise in present-day-like spiral galaxies which are immersed in isothermal dark matter halos, (ii) that these galaxies obey the Tully-Fisher sigma/sigma_* = (L/L_*)^1/alpha_TF and the Holmberg R_L/R_* = (L/L_*)^alpha_H relations, and (iii) that they follow the Schechter luminosity distribution, we describe how their observed number density (dN/dz), distribution of column density (f(N)) as well as inferred cosmological density of HI (Omega_HI) derived from DLA surveys are affected by gravitational lensing (GL). The `by-pass' effect causes the lines-of-sight (LOSs) towards background QSOs to avoid the central parts of galaxies and reduces their effective cross-section for absorption; the `amplification bias' leads observers to select QSOs whose LOSs preferentially cross galaxies close to their Einstein radius. As a consequence, the determination of the quantities dN/dz, f(N) and Omega_HI from DLA surveys does not only depend on the redshift z and luminosity L of galaxies responsible for the absorbers but also on the column density profile of HI within the galaxies and on the redshift z_q and magnitude b_q of the background QSOs. For most of the existing surveys using b_q <~ 19 QSOs, the amplification bias dominates the combined effect resulting in a slight overestimate of dN/dz, f(N) and Omega_HI. We mainly find that observational strategies presently used to produce high-z DLA surveys result in avoiding the signature of significant GL effects: following our model, we determine that an overestimate of Omega_HI by more than 10% is unlikely for the z > 1.7 existing surveys, but may reach ~= 35% for the low redshift ones. However, we show that, in the absence of extinction by dust and micro-lensing effects, surveys ideally designed to enhance GL effects, i.e. to search for DLAs at z ~ 0.5 in front of very bright (b_q ~= 16), high-z (z_q > 1) QSOs, may lead 1) to overestimate by up to ~= 90% the number of DLAs per unit redshift; 2) to bias the survey towards high HI column density systems so that it could contain up to 4 times as many such systems, thus 3) to overestimate by up to ~= 170% the cosmological density of gas associated with those DLAs. Identification of the galaxies responsible for the DLAs may be severely biased towards luminous galaxies if 2/alpha_TF - alpha_H>0 this latter effect is greatly increased for log N_HI > 21 DLAs. Hence, GL effects on the quantities derived from surveys for z ~ 0.5 DLAs are of the same order, but of opposite direction, as the effects of extinction by dust (cf. Fall & Pei, 1993). However, the GL and dust extinction effects do not compensate each other: combining them in a consistent way is necessary to interpret existing DLA surveys. Furthermore, the effects due to micro-lensing should be simultaneously taken into account. We intend to report the results on the complex interplay between macro-lensing, micro-lensing and dust in a subsequent paper. We briefly present statistical tests specifically designed to check whether GL affects existing DLA surveys, and assuming that extinction by dust is negligible. We only find indications of GL effects for the z < 1 ones which, if confirmed, might even be stronger than predicted by our model. We show that an independent work on the same subject by Bartelmann & Loeb (1996) incorrectly treats the inclination effects for the intervening galaxies, thus undermining some of their main results and conclusions. [less ▲]

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See detailEvaluation d'un programme intensif de revalidation pour travailleurs lombalgiques
Mairiaux, Philippe ULg; Oblin, Marc

in Archives des Maladies Professionnelles et de Médecine du Travail (1997), 58(5), 432439

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See detailIndependent prognostic value of the 67-kd laminin receptor in human prostate cancer
Waltregny, David ULg; de Leval, Laurence ULg; Menard, Sylvie et al

in Journal of the National Cancer Institute (1997), 89(16), 1224-7

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See detailTwo Members Of The Human Mageb Gene Family Located In Xp21.3 Are Expressed In Tumors Of Various Histological Origins
Lurquin, C.; De Smet, C.; Brasseur, F. et al

in Genomics (1997), 46(3), 397-408

Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. Twelve closely related MAGE genes are located in the Xq28 region ... [more ▼]

Genes of the MAGE family direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. Twelve closely related MAGE genes are located in the Xq28 region. These genes share 60-98% nucleotide identity in their coding region. The presence of homologous genes in a region of Xp21.3 has been reported previously. We obtained the complete sequence of a 42-kb stretch of this region. It contains four MAGE-related genes, which we propose to name MAGE-B1, B2, B3, and B4 (HGMW-approved symbols MAGEB1, MAGEB2, MAGEB3, and MAGEB4). The coding regions of these genes share 66-81% nucleotide identity and show 45-63% identity with those of the MAGE genes located in Xq28. Like the MAGE genes located in Xq28, the MAGE-B genes are silent in normal tissues with the exception of testis. Like MAGE-1, 2, 3, 4, 6 and 12 (HGMW-approved symbols MAGEA1, 2, 3, 4, 6, and 12), genes MAGE-B1 and MAGE-B2 are expressed in a significant fraction of tumors of various histological types. The transcription of MAGE-B1 and MAGE-B2 can be induced by 5-aza-2'-deoxycytidine, suggesting that the activation of these genes in tumors results from a demethylation process. [less ▲]

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See detailVaccinia virus immune evasion
Smith, G. L.; Symons, J. A.; Khanna, A. et al

in Immunological Reviews (1997), 159

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include ... [more ▼]

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines. [less ▲]

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See detailContribution à l'étude de la flore et de l'écologie des plantes de quelques grottes wallonnes.
Garbacki, Nancy ULg

in Bulletin des Chercheurs de la Wallonie (1997), XXXVI

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See detailDesign for an Ipriflavone Multicenter European Fracture Study
Reginster, Jean-Yves ULg; Bufalino, L.; Christiansen, C. et al

in Calcified Tissue International (1997), 61(Suppl 1), 28-32

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large ... [more ▼]

In order to investigate the efficacy of ipriflavone (i.p.) on the prevention of vertebral fractures and the effect on bone mineral density (BMD) in women with postmenopausal osteoporosis, a large multicentric European study was designed and is presently ongoing. Included in the study were 460 Caucasian, nonobese postmenopausal women aged > 45 and < 75 years, menopaused for at least 12 months. Inclusion was on the basis of a lumbar bone mineral density (BMD) lower than 2 SD compared with healthy women aged 50 years, corresponding to values below 0.860 g/cm2 (antero-posterior measurement) by Hologic QDR 1000. Women with prevalent vertebral fractures were excluded as well as those presenting secondary osteoporosis or having been treated with medications that could affect bone metabolism. This study was designed as a 3-year, double-blind, placebo-controlled, parallel group study that randomized the women to the oral administration of either 3 x 200 mg/day of i.p. or placebo. All patients received a daily supplement of 500 mg calcium. The primary purpose of the study was to evaluate the efficacy of i.p. in preventing vertebral nontraumatic fractures. Fracture is defined here as a > or = 20% decrease in any anterior, central, or posterior T4-L4 vertebral height. Blinded vertebral X-ray readings and vertebral morphometry have been centralized in an independent Center, with standardized evaluation of two experts. Power calculations have been based on the hypothesis that 21% of placebo-treated patients would fracture within 3 years and that treatment with i.p. would lead to a 50% reduction in the incidence of fracture. Statistical tests have been designed to have a power of 80%, with a type I error equal to 5%. Secondary endpoints were changes in vertebral, radial, and femoral BMD. Centralized controls on 100% BMD scans would ensure the good quality of BMD readings. This study should verify the hypothesis that i.p. significantly decreases the risk of vertebral fracture in postmenopausal, osteoporotic women. [less ▲]

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See detailMonoclonal Antibody Production - The Report And Recommendations Of Ecvam Workshop 23
Marx, U.; Embleton, Mj.; Fischer, R. et al

in Alternatives to Laboratory Animals (1997), 25(2),

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See detailLuc et Jean-Pierre Dardenne. Vingt ans de travail en cinéma et vidéo (1976-1996)
Van Cauwenberge, Geneviève ULg; Bajomée, Danielle ULg; Delruelle, Edouard ULg et al

in Revue belge du cinéma (1997), 41(Hiver), 96

Historical and analytical overview of the Dardenne’s cinématographic and videographic work from 1976 to 1996, with an interview with Luc and Jean-Pierre Dardenne. A lot of issues about the survivor’s ... [more ▼]

Historical and analytical overview of the Dardenne’s cinématographic and videographic work from 1976 to 1996, with an interview with Luc and Jean-Pierre Dardenne. A lot of issues about the survivor’s memory, the history consciousness, the wounds of memory, the survivor’s speech ; the memory of the social struggle ; the derelction and the transformation of the society ; the résistance ; the videographic and filmic forms and patterns (landscape, face, water, reality) ; the theatrical space and the relations between theatre and cinéma. [less ▲]

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See detailImplication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma.
Gilles, Christine ULg; Polette, M.; Seiki, M. et al

in Laboratory Investigation : Journal of Technical Methods & Pathology (1997), 76(5), 651-60

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I ... [more ▼]

We have previously demonstrated that fibroblasts and invasive human breast carcinoma (HBC) cells specifically activate matrix metalloproteinase-2 (MMP-2) when cultured on 3-dimensional gels of type I collagen but not a range of other substrates. We show here the constitutive expression of membrane-type 1 (MT1)-MMP in both fibroblasts, and invasive HBC cell lines, that have fibroblastic attributes presumably acquired through an epithelial-to-mesenchymal transition (EMT). Treatment with collagen type I increased the steady-state MT1-MMP mRNA levels in these cells but did not induce either MT1-MMP expression or MMP-2 activation in noninvasive breast carcinoma cell lines, which retain epithelial features. Basal MT3-MMP mRNA expression had a pattern similar to that of MT1-MMP but was not up-regulated by collagen. MT4-MMP mRNA was seen in both invasive and noninvasive HBC cell lines and was also not collagen-regulated, and MT2-MMP mRNA was not detected in any of the HBC cell lines tested. These data support a role for MT1-MMP in the collagen-induced MMP-2-activation seen in these cells. In situ hybridization analysis of archival breast cancer specimens revealed a close parallel in expression of both collagen type I and MT1-MMP mRNA in peritumoral fibroblasts, which was correlated with aggressiveness of the lesion. Relatively high levels of expression of both mRNA species were seen in fibroblasts close to invasive tumor nests and, although only focally, in certain areas close to preinvasive tumors. These foci may represent hot spots for local degradation and invasive progression. Collectively, these results implicate MT1-MMP in collagen-stimulated MMP-2 activation and suggest that this mechanism may be employed in vivo by both tumor-associated fibroblasts and EMT-derived carcinoma cells to facilitate increased invasion and/or metastasis. [less ▲]

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See detailEffect of n-3 fatty acids in Eurasian perch broodstock diet on egg fatty acid composition and larva stress resistance.
Abi-Ayad, Amine; Mélard, Charles ULg; Kestemont, Patrick

in Aquaculture International (1997), 5

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See detailRegolazione della crescité follicolare e luteinica. Folliculogenesi e atresia. Summa.
Drion, Pierre ULg; Beckers, Jean-François ULg; Ectors, Fabien ULg et al

in Summa (1997), 14(9), 5-16

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for ... [more ▼]

Hypophyseal production of FSH and LH depends on a pulsating secretion of GnRH by the Hypothalamus. At the beginning of the cycle, this secretion sets free the FSH from the hypothesis responsible for follicular recruiment. The recruited follicles produce estradiol, inhibin and follistatin which reduce the FSH secretion (negative feed back) reducing their support to hormonodependant follicles which become atresic. The dominant follicle, subjected to internal self stimulation is not sensitive to the reduction in FSH levels and carries on synthesising more and more estradiol. [less ▲]

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See detailQuelle est la place de l’Université dans notre société ?
Brunet, Sébastien ULg

in Revue l’Observatoire (1997), 15

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See detailThe role of bisphosphonates in the treatment of osteoporosis
Reginster, Jean-Yves ULg; Halkin, V.; Gosset, Christiane ULg et al

in Drugs of Today (Barcelona, Spain : 1998) (1997), 33

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See detailSpectroscopy of Ne IV in the wavelength Range 450–1100 Å
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Journal of the Optical Society of America. B, Optical Physics (1997), 14

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution ... [more ▼]

An analysis of the Ne IV spectrum was undertaken in the 450–1100-Å spectral range. The spectra were produced by the beam–foil method with beam energies of 1.2 and 2.5 MeV, respectively. The resolution that was achieved, with a normal-incidence 2-m spectrometer, was sufficient to identify 53 new Ne IV lines and, consequently, to determine 18 new levels in the quartet and doublet systems and one sextet term. The energy values of 13 additional levels were also revised. The classification work was facilitated by the use of scaled relativistic Hartree–Fock calculations. [less ▲]

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See detailCompte rendu de J.N.D. KELLY, Dictionnaire des papes, Turnhout, 1994
Marchandisse, Alain ULg

in Moyen Age (Le) (1997), 103

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See detailEtablissement d'un plan volontaire de contrôle de la rhinotrachéite infectieuse bovine en région wallonne de Belgique
De Wergifosse, Bertrand; Lemaire, Mylène; Pastoret, Paul-Pierre ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailTiming effect of combined radioimmunotherapy and radiotherapy on a human solid tumor in nude mice.
Coucke, Philippe ULg; Lin-Quan, Sun; Vogel, Charles-André et al

in Cancer Research (1997), 57

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were ... [more ▼]

Timing effects of radioimmunotherapy (HIT) combined with external beam radiotherapy (RT) were assessed In human colon carcinoma xe nografts. Initially, dose effects offractlonated RT and RIT were evaluated separately. Then, 30 Gy RT (10 fractions over 12 days) were combined with three weekly Lv. injections of 200 g@Ci of 131I-labeled anti-carcino embryonic antigen monoclonal antibodies in four different treatment schedules. RIT was given either prior to, concurrently, Immediately after, or 2 weeks after RT administration. The longest regrowth delay (RD) of 105 days was observed in mice treated by concurrent administration of RT and lilT, whereas the RDs of RT and RIT alone were 34 and 20 days, respectively. The three sequential combination treatments produced sig nificantly shorter RDs ranging from 62 to 70 days. The tumor response represented by the minimal volume (MV) also showed that concurrent administration of RT and RIT gave the best result, with a mean MV of 4.5% as compared to MVs from 26 to 53% for the three sequential treatments. The results were confirmed In a second experiment, In which a RT of 40 Gy was combined with an identical lilT as above (three injections of 200 g&Ci of ‘31I-labeled monoclonal antibodies). At compa rable toxicity levels, the maximum tolerated RT or BIT alone gave shorter RDs and less tumor shrinkage compared to slinultaneous RT+RIT. These results may be useful for designing clinical protocols ofcombined RIT and RT. [less ▲]

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See detailEuroback : Goals and achievement after one year
Jérome, Simone; Thirion, Paul ULg

in Serials Review (1997), 23(1), 53-56

EUROBACK is but a European clone of BackServ. It was launched because those who conceived it had a positive experience with the American-based electronic list. This article will explore why EUROBACK is ... [more ▼]

EUROBACK is but a European clone of BackServ. It was launched because those who conceived it had a positive experience with the American-based electronic list. This article will explore why EUROBACK is necessary as a separate list, and it will compare librarianship on the North American and European continents, where library materials are viewed quite differently. [less ▲]

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See detailInterobserver agreement on MNA nutritional scale of hospitalized elderly patients
Gazzotti, C.; Pepinster, A.; Petermans, Jean ULg et al

in Journal of Nutrition, Health & Aging (The) (1997), 1

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See detailComplexation of uranyl ion by polyvinylimidazole: Electrochemical preparation and leaching tests investigations
Martinot, Lucien; Leroy, D.; Jérôme, Christine ULg et al

in Journal of Radioanalytical & Nuclear Chemistry (1997), 224(1-2), 71-76

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical ... [more ▼]

In this work, we intend to check the claims of an U.S. Patent (Westinghouse E.C.) which describes an original treatment for low level activity radioactive wastes. The process deals with electrochemical preparation of polyvinylimidazole (PVI) which is a polymer capable of complexing uranyl ions. We confirm the complexation of uranyl ions by PVI in various media by FT-IR and UV-Visible analysis but all these complexes were found to be soluble in water so we put forward new complexes with an additional polymer to shape out insoluble complex. Leaching tests demonstrate the efficiency of our process. [less ▲]

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See detailElementverteilung in einem moorprofil (Präboreal bis subatlantikum) im Tal der Helle/Hill (Hohes Venn, Belgien)
Gaida, R.; Olbrechts, S.; Hindryckx, Marie-Noëlle ULg et al

in Geoökodynamik (1997), XVIII(2/3), 79-90

This investigation was on the distribution of some elements (Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Ni, Pb, Zn) in a groundwater bog in the Helle/Hill valley in the Hohes Venn, Belgium. The thickness of the ... [more ▼]

This investigation was on the distribution of some elements (Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Ni, Pb, Zn) in a groundwater bog in the Helle/Hill valley in the Hohes Venn, Belgium. The thickness of the deposit is 155 cm. This bog has developed since the Pre Boreal period. The distribution in the lower part of the bog profile is very strongly influenced by water from the adjacent slope which is characterised by a high content of different metals. This resulted in a significant amount of Fe, Ni and Zn and to a lesser degree of Cu and Cd. The metals stem from ore which originated from the nearby Hill valley tonalite. The weathering of the sulphidic ore created sulphuric acid which is responsible for the low pH values of the peat samples. Not only the influence of the local geology and mineralogy is discussed, but also the behaviour of different plants with respect to element uptake and accumulation. Atmospheric input also has an influence, especially on the distribution of the elements in the upper part of the profile. [less ▲]

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See detailFin du Millénaire - fin de l'Agriculture
Schirmer, Jacek; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1997), 33

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See detailRadiographical Assessment of Interphalangeal Rotation in the Evaluation of Equine Digital Conformation
Caudron, I.; Grulke, Sigrid ULg; Gabriel, Annick ULg et al

in Acta Anatomica (1997), 160(2), 95-9

This study is a part of a work to design a radiographical method to objectively define the conformation of an equine digit and to assess the individual appropriate trimming of a horse. Various angles were ... [more ▼]

This study is a part of a work to design a radiographical method to objectively define the conformation of an equine digit and to assess the individual appropriate trimming of a horse. Various angles were measured directly from the phalangeal bones. The authors observed that the bone relief of the sesamoid ligament insertions on the proximal phalanx was an essential landmark to determine the phalangeal alignment. The same angles were measured from specific radiographs and made it possible to quantify the rotation imposed to the proximal phalanx. The authors also noticed that the phalangeal rotation had little influence on the radiographic image of articular asymmetry. [less ▲]

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See detailVerapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Diabetologia (1997), 40

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See detailA 5,6-Dihydro-Isopyoverdin From Azomonas Macrocytogenes
Michalke, R.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(11-12),

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See detailDeux POHLIA méconnus d'Alsace: P.lutescens (Limpr.) Lindb. et P. lescuriana (Sull.) Andrews
Vanderpoorten, Alain ULg

in Bulletin de la Société d'Histoire Naturelle de Colmar (1997), 63

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See detailLa nature de l'acte juridique attesté par l'O. Mich. III 1098
Straus, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1997), LXXII(143), 128-129

O. Mich. III 1098 attests the delivery of a slave as a surety of a loan.

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See detailRegolazione della crescité follicolare e luteinica. Ovulazione, corpo luteo e luteolisi. Summa.
Drion, Pierre ULg; Ectors, F. J.; Hanzen, Christian ULg et al

in Riproduzione dei ruminanti (1997), 14(9), 17-25

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See detailEffect of activators and inhibitors of K+-channels on insulin secretion in the amphibian pancreas
Francini, F.; Pirotte, Bernard ULg; Gagliardino, J. J.

in Archives of Physiology & Biochemistry (1997), 105

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See detailHuman TEF-5 is preferentially expressed in placenta and binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer
Jacquemin, Patrick; Martial, Joseph ULg; Davidson, Irwin

in Journal of Biological Chemistry (1997), 272(20), 12928-37

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in ... [more ▼]

We report the cloning of a cDNA encoding the human transcription factor hTEF-5, containing the TEA/ATTS DNA binding domain and related to the TEF family of transcription factors. hTEF-5 is expressed in skeletal and cardiac muscle, but the strongest expression is observed in the placenta and in placenta-derived JEG-3 choriocarcinoma cells. In correlation with its placental expression, we show that hTEF-5 binds to several functional enhansons of the human chorionic somatomammotropin (hCS)-B gene enhancer. We define a novel functional element in this enhancer comprising tandemly repeated sites to which hTEF-5 binds cooperatively. In the corresponding region of the hCS-A enhancer, which is known to be inactive, this element is inactivated by a naturally occurring single base mutation that disrupts hTEF-5 binding. We further show that the binding of the previously described placental protein f/chorionic somatomammotropin enhancer factor-1 to TEF-binding sites is disrupted by monoclonal antibodies directed against the TEA domain and that this factor is a proteolytic degradation product of the TEF factors. These results strongly suggest that hTEF-5 regulates the activity of the hCS-B gene enhancer. [less ▲]

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See detailLa prééclampsie est la conséquence d'un déficit de placentation: de la biologie aux considérations cliniques
Maquoi, Erik ULg; Schaaps, Jean-Pierre ULg; Jacobs, J. L. et al

in Revue Médicale de Liège (1997), 52(7), 478-84

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See detailEn mai élis qui te plaît
Durand, Pascal ULg

in Liège Université (1997), (été), 3

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See detailDamping rates of hard momentum particles in a cold ultrarelativistic plasma
Vanderheyden, Benoît ULg; Ollitrault, J. Y.

in Physical Review. D : Particles and Fields (1997), 56(8), 5108-5122

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar ... [more ▼]

We compute the damping rates of one-particle excitations in a cold ultrarelativistic plasma to leading order in the coupling constant e for three types of interaction: Yukawa coupling to a massless scalar boson, QED, and QCD. Damping rates of charged particles in QED and QCD are of order e(3) mu, while the damping rates of other particles are of order e(4) mu or e(4) mu log(1/e). We find that the damping rate of an electron or of a quark is constant far from the Fermi surface, and decreases linearly with the excitation energy close to the Fermi surface. This unusual behavior is attributed to the long-range magnetic interactions. [less ▲]

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See detailSporopodiopsis, a new genus of lichens (Ectolechiaceae) from S-E Asia
Sérusiaux, Emmanuël ULg

in Abstracta Botanica (1997), 21

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See detailAnti-PMSG in sheep subjected annualy to oestrus synchronisation
Bodin, L.; Drion, Pierre ULg; Remy, Benoit et al

in Reproduction Nutrition Development (1997), 37

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks ... [more ▼]

Estimation of the long-term consequences on reproduction performance of the oestrus synchronisation treatments that are annually applied to ewes was carried out on nine officially controlled dairy flocks in the Roquefort region of France. A hormonal treatment combining the insertion of a vaginal fluoro-gestone acetate (FGA) sponge for 14 days and the injection of about 500 IU of pregnant mare serum gonadotropin (PMSG) at withdrawal was applied to the ewes in seven of the nine flocks. The ewes in the two other flocks were used as controls. Blood samples were taken from each female just before the treatment (to test for the presence of residual antibodies) and 20 days after the PMSG injection. Anti-PMSG antibody binding rates were calculated for each blood sample. The residual binding rate increased with age and induce negative effects on the following years reproduction performances, ie, they increased the probability that the ewes would not become pregnant. [less ▲]

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See detailNote on the measurement of the thermal conductivity and the double peak structure in high-Tc superconductors
Bougrine, Hassan ULg; Pekala, M.

in Superconductor Science & Technology (1997), 10(8), 621-623

We show that low-temperature measurements of the thermal conductivity of high-T-c superconductors can sometimes reveal a double peak structure depending on the experimental set-up used.

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