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See detailPirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition
Boland, André ULg; Gerardy, J.; Breeur, Danielle ULg et al

in British Journal of Pharmacology (2002), 135(3), 713-720

1 It has been shown that the MAO (monoamine oxidase)-B inhibitor deprenyl (DPR, selegiline) protects some cell types against oxidative stress. By decreasing H2O2 production, MAO-A inhibitors could also ... [more ▼]

1 It has been shown that the MAO (monoamine oxidase)-B inhibitor deprenyl (DPR, selegiline) protects some cell types against oxidative stress. By decreasing H2O2 production, MAO-A inhibitors could also reduce oxidative stress. 2 This study reports the effect of the MAO-A inhibitors, pirlindole (PIR), dehydropirlindole (DHP), brofaromine (BRO) and moclobemide (MCL) on primary-cultured brain cells exposed to iron-mediated toxicity. A comparison with trolox (TRO), a hydrosoluble vitamin-E analogue that protects against such an induced stress, was performed. 3 Rat hippocampal or cortical cultured cells were exposed either to 2 mum FeSO4 alone or in the presence of PIR, DHP, BRO, DPR, MCL or TRO. Cell survival (lactate-dehydrogenase measurements, 16 h incubation), intracellular peroxide production (DCF-fluorescence. I h incubation), lipoperoxidation (TBARS-fluorescence, 6 h incubation) and mitochondrial function (MTT-test, 16 h incubation) were assessed. 4 PIR, DHP and TRO significantly protected cultures (P<0.05) against Fe2+-induced toxicity in a concentration-dependent manner. The EC50s of these compounds were 6, 12 and 19 muM, respectively, in hippocampal cells. For cortical cell cultures incubated in the presence of iron and PIR or DHP, EC50s were 5 and 6 muM respectively. All Hill coefficients were close to unity. BRO, MCL and DPR were not protective in any type of culture. The IC50s for the inhibition of MAO-A were 2, 2 and 0.2 muM for PIR, DHP and BRO, respectively. PIR, DHP and TRO, but not DPR, induced a significant decrease in both intracellular peroxide production and lipoperoxidation. They also improved mitochondrial function. 5 These experiments show that PIR and DHP can protect hippocampal and cortical neurons against oxidative stress at pharmacologically relevant concentrations. This protective effect seems unrelated to inhibition of MAO-A, but possibly involves free radical scavenging. [less ▲]

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See detailCrystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin
Fonzé, Evelyne; Vanhove, Mac; Dive, Georges ULg et al

in Biochemistry (2002), 41(6), 1877-1885

The Bacillus licheniformis BS3 beta-lactamase catalyzes the hydrolysis of the beta-lactam ring of penicillins, cephalosporins, and related compounds. The production of beta-lactamases is the most common ... [more ▼]

The Bacillus licheniformis BS3 beta-lactamase catalyzes the hydrolysis of the beta-lactam ring of penicillins, cephalosporins, and related compounds. The production of beta-lactamases is the most common and thoroughly studied cause of antibiotic resistance. Although they escape the hydrolytic activity of the prototypical Staphylococcus aureus beta-lactamase, many cephems are good substrates for a large number of beta-lactamases. However, the introduction of a 7alpha-methoxy substituent, as in cefoxitin, extends their antibacterial spectrum to many cephalosporin-resistant Gram-negative bacteria. The 7alphamethoxy group selectively reduces the hydrolytic action of many beta-lactamases without having a significant effect on the affinity for the target enzymes, the membrane penicillin-binding proteins. We report here the crystallographic structures of the BS3 enzyme and its acyl-enzyme adduct with cefoxitin at 1.7 Angstrom resolution. The comparison of the two structures reveals a covalent acyl-enzyme adduct with perturbed active site geometry, involving a different conformation of the Omega-loop that bears the essential catalytic Glu166 residue. This deformation is induced by the cefoxitin side chain whose position is constrained by the presence of the alpha-methoxy group. The hydrolytic water molecule is also removed from the active site by the 7beta-carbonyl of the acyl intermediate. In light of the interactions and steric hindrances in the active site of the structure of the BS3-cefoxitin acyl-enzyme adduct, the crucial role of the conserved Asn132 residue is confirmed and a better understanding of the kinetic results emerges. [less ▲]

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See detailActivation of the supplementary motor area and of attentional networks during temporal processing
Macar, F.; Lejeune, Helga ULg; Kirsch, Murielle ULg et al

in Experimental Brain Research (2002), 142(4), 475-485

This paper first provides a survey of the expanding brain imaging literature in the field of time processing. showing that particular task features (discrete vs rhythmic, perceptual vs motor) do not ... [more ▼]

This paper first provides a survey of the expanding brain imaging literature in the field of time processing. showing that particular task features (discrete vs rhythmic, perceptual vs motor) do not significantly affect the basic pattern of activation observed. Next, positron emission tomography (PET) data obtained in a timing task (temporal reproduction) with two distinct duration ranges (2.2-3.2 and 9-13 s) are reported. The stimuli consisted of vibrations applied to the subject's right middle finger. When the vibration ended, the subject estimated an interval identical to its length before pressing a response button. The control task used cued responses with comparable intervals and stimuli, The pattern of activation obtained in the timing task as compared to control mainly included areas having attentional functions (the right dorsolateral prefrontal, inferior parietal, and anterior cingulate cortices), and the supplementary motor area (SMA). No significant difference was seen as a function of the duration range. It is argued, firstly. that involvement of the attentional areas derives from specific relations between attention and the temporal accumulator, as described by dominant timing models. and, secondly, that the SMA, or more probably one of its subregions, subserves time processing [less ▲]

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See detailReactivación de las negociaciones Euro-Mercosur bajo el temor del ‘síndrome mejicano’?
Santander, Sébastian ULg

in Revista de Derecho Internacional y del Mercosur (2002), 1

L'UE agit semble avoir une stratégie réactive sur la scène internationale. La mise en place de l'ALENA a eu un effet de commerce important au détriment de l'UE mais au profit des Etats-Unis. Cette ... [more ▼]

L'UE agit semble avoir une stratégie réactive sur la scène internationale. La mise en place de l'ALENA a eu un effet de commerce important au détriment de l'UE mais au profit des Etats-Unis. Cette conséquence négative a poussé les instances européennes à négocier et conclure rapidement l'accord global avec le Mexique. La même situation semble se produire dans les relations avec le Mercosur. [less ▲]

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See detailPituitary disease in MEN type 1 (MEN1): Data from the France-Belgium MEN1 multicenter study
Vergès, B.; Boureille, F.; Goudet, P. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87(2), 457-465

To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We analyzed the data of a large series of 324 MEN1 patients from a French and Belgian multicenter study. Data on ... [more ▼]

To date, data on pituitary adenomas in MEN type 1 (MEN1) still have to be evaluated. We analyzed the data of a large series of 324 MEN1 patients from a French and Belgian multicenter study. Data on pituitary disease were compared with those from 110 non-MEN1 patients with pituitary adenomas, matched for age, year of diagnosis, and follow-up period. Genetic analysis of the MEN1 gene was performed in 197 of the MEN1 patients. In our MEN1 series, pituitary disease occurred in 136 of 324 (42%), less frequently than hyperparathyroidism (95%, P < 0.001) and endocrine enteropancreatic tumors (54%, P < 0.01). Mean age of onset of pituitary tumors was 38.0 +/- 15.3 yr (range, 12-83 yr). Pituitary disease was associated with hyperparathyroidism in 90%. of cases, with enteropancreatic tumors in 47%, with adrenal tumors in 16%, and with thoracic neuroendocrine tumors in 4%. Pituitary disease was the initial lesion of MEN1 in 17% of all MEN1 patients. MEN1 pituitary adenomas were significantly more frequent in women than in men (50% vs. 31%,P < 0.001). Among the 136 pituitary adenomas, there were 85 prolactinomas and 12 GH-secreting, 6 ACTH-secreting, 13 cosecreting, and 20 nonsecreting tumors. Eighty-five percent of MEN1-related pituitary lesions were macroadenomas (vs. 42% in non-MEN1 patients, P < 0.001), including 32% of invasive cases. Among secreting adenomas, hormonal hypersecretion was normalized, after treatment, in only 42% (vs. 90% in non-MEN1 patients, P < 0.001), with a median follow-up of 11.4 yr. No correlation was found between the type of MEN1 germ-line mutation and the presence or absence of pituitary adenoma. Our study, based on a large group of MEN1 patients, shows that pituitary adenomas occur in 42% of the cases and are characterized by a larger size and a more aggressive presentation than without MEN1. [less ▲]

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See detailAn optical time-delay for the lensed BAL quasar HE 2149-2745
Burud, I.; Courbin, F.; Magain, Pierre ULg et al

in Astronomy and Astrophysics (2002), 383(1), 71-81

We present optical V and i-band light curves of the gravitationally lensed BAL quasar HE 2149-2745. The data, obtained with the 1.5 m Danish Telescope (ESO-La Silla) between October 1998 and December 2000 ... [more ▼]

We present optical V and i-band light curves of the gravitationally lensed BAL quasar HE 2149-2745. The data, obtained with the 1.5 m Danish Telescope (ESO-La Silla) between October 1998 and December 2000, are the first from a long-term project aimed at monitoring selected lensed quasars in the Southern Hemisphere. A time delay of 103+/-12 days is determined from the light curves. In addition, VLT/FORS1 spectra of HE 2149 2745 are deconvolved in order to obtain the spectrum of the faint lensing galaxy, free of any contamination by the bright nearby two quasar images. By cross-correlating the spectrum with galaxy-templates we obtain a tentative redshift estimate of z = 0.495+/-0:01. Adopting this redshift, a Omega = 0.3, Lambda = 0.7 cosmology, and a chosen analytical lens model, our time-delay measurement yields a Hubble constant of H-0 = 66+/-8 km s(-1) Mpc(-1) (1sigma error) with an estimated systematic error of +/-3 km s(-1) Mpc(-1). Using non-parametric models yields H-0 = 65+/-8 km s(-1) Mpc(-1) (1sigma error) and confirms that the lens exhibits a very dense/concentrated mass profile. Finally, we note, as in other cases, that the flux ratio between the two quasar components is wavelength dependent. While the flux ratio in the broad emission lines-equal to 3.7-remains constant with wavelength, the continuum of the brighter component is bluer. Although the data do not rule out extinction of one quasar image relative to the other as a possible explanation, the effect could also be produced by differential microlensing by stars in the lensing galaxy. [less ▲]

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See detailMinimal effects of JL 13, a pyridobenzoxazepine derivative with an antipsychotic potential, on circulating prolactin levels in male rats
Liégeois, Jean-François ULg; Bruhwyler, J.; Hendrick, J. C. et al

in Neuroscience Letters (2002), 319(1), 49-52

Antipsychotic therapy is frequently associated with several side effects such as hyperprolactinemia. The influence of a putative antipsychotic JL 13 on prolactin release was assessed after intraperitoneal ... [more ▼]

Antipsychotic therapy is frequently associated with several side effects such as hyperprolactinemia. The influence of a putative antipsychotic JL 13 on prolactin release was assessed after intraperitoneal injection in gentled male rats in comparison with clozapine and haloperidol. A total of 30 or 150 min after administration, whole blood was collected for preparing serum samples. Prolactin was quantified by radioimmunoassay method. At 30 min, JL 13 like clozapine, increased prolactin concentration only at the higher dose (30 mg/kg) while haloperidol at both tested doses induced a dramatic increase of prolactin concentration. At 150 min after injection, only haloperidol (0.3 mg/kg) significantly increased serum prolactin level. This minimal effect on prolactinemia reinforces the similarity of clozapine and JL 13 regarding the atypical antipsychotic profile. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailNormal mere exposure effect with impaired recognition in Alzheimer's disease
Willems, Sylvie ULg; Adam, Stéphane ULg; Van der Linden, Martial ULg

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2002), 38(1), 77-86

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects ... [more ▼]

We investigated the mere exposure effect and the explicit memory in Alzheimer's disease (AD) patients and elderly control subjects, using unfamiliar faces. During the exposure phase, the subjects estimated the age of briefly flashed faces. The mere exposure effect was examined by presenting pairs of faces (old and new) and asking participants to select the face they liked. The participants were then presented with a forced-choice explicit recognition task. Controls subjects exhibited above-chance preference and recognition scores for old faces. The AD patients also showed the mere exposure effect but no explicit recognition. These results suggest that the processes involved in the mere exposure effect are preserved in AD patients despite their impaired explicit recognition. The results are discussed in terms of Seamon et al.'s (1995) proposal that processes involved in the mere exposure effect are equivalent to those subserving perceptual priming. These processes would depend on extrastriate areas which are relatively preserved in AD patients. [less ▲]

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See detailEnucleation of a giant hepatic hemangioma in a Jehovah's Witness
Detry, Olivier ULg; Honore, Pierre ULg; Joris, Jean ULg et al

in Acta Chirurgica Belgica (2002), 102(1), 54-56

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See detailEffect of block copolymers of various molecular architecture on the phase morphology and tensile properties of LDPE rich (LDPE/PS) blends
Harrats, Charef; Fayt, R.; Jérôme, Robert ULg

in Polymer (2002), 43(3), 863-873

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has ... [more ▼]

The emulsification efficiency of three different block copolymers consisting of hydrogenated polybutadiene (HPB) and polystyrene (PS), i.e. a pure diblock , a tapered diblock and a triblock copolymer has been compared in low density polyethylene/polystyrene (LDPE/PS) blends rich in polyethylene. The comparison relies upon the ability of these potential interfacial agents to stabilize fine phase dispersion and to promote good interfacial adhesion. Based on the phase morphology, the ultimate tensile properties and the dynamic viscosity of the modified blends, the tapered diblock copolymer is clearly the most efficient emulsifier. For instance a plateau is observed in the property-copolymer content dependence when 2 wt% tapered diblock are used compared to ca. 5 wt% in case of the pure diblock. In contrast, no plateau is observed when the triblock copolymer is used. This is assumed to result from a less quantitative localization of these two copolymers i.e. the pue diblock or the triblock at the LDPE/PS interface. [less ▲]

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See detailLe cathétérisme bilatérale des sinus pétreux avec dosages multihormonaux dans la maladie de Cushing
Valdes Socin, Hernan Gonzalo ULg; Bataille, Yoann ULg; Meurisse, Nicolas ULg et al

in Annales d'Endocrinologie (2002), 63(1), 23-30

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI ... [more ▼]

Multihormonal bilateral petrosal sinus sampling (BPSS) has been proposed to improve corticotroph microadenomas prediction of lateralisation. Few series have simultaneously compared data of pituitary MRI, surgical findings and multihormonal BPSS. Seven patients (6F/1M) with Cushing's disease, mean age at diagnosis of 35 years (range 24-55) were prospectively studied to compare radiological and multihormonal BPSS data with surgical and pathological findings. In untreated patients, simultaneous measures of ACTH, TSH and prolactine (PRL) were done at time 0, 7, 15, 22 minutes after CRH (500 mg) and TRH (200 mg) stimulation. An intersinus gradient of 1.4 was considered as a lateralisation. All microadenomas were identified during surgery, diameters ranged from 2 to 7 mm. All patients were in long-term surgical remission. Pathological studies confirmed a tumoral tissue with ACTH immunostaining in 6/7 cases and PRL in 3/7 cases. Pituitary MRI correctly identified tumors in 4 cases, the remaining tumors were not seen. Basal and stimulated intersinus gradients of ACTH, TSH and PRL were homolateral in 6/7 cases and were coincident with surgical findings in 4/7 cases. The other three cases were contralateral to MRI and surgical data. In conclusion, simultaneous gradient of ACTH, PRL and TSH did not improve lateralisation prediction in this series. Hormonal hypersecretion was homolateral in six cases whereas pathological studies demonstrated a mixed secretion in only three cases. A preferential pituitary draining could explain these discordances. Data from our series and from others (done with CRH stimulation and ACTH-PRL measures) strongly suggest a paracrine interaction between tumoral and normal pituitary tissue. [less ▲]

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See detailEpidemiology of inflammatory bowel diseases in the elderly in the province of Liege - A three-year prospective study
Piront, Patricia ULg; Louis, Edouard ULg; Latour, Pascale ULg et al

in Gastroentérologie Clinique et Biologique (2002), 26(2), 157-161

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See detailEtude clinique du mois. Radio-chimiotherapie et chimiotherapie adjuvante apres resection a visee curative du cancer du pancreas: resultats de l'etude randomisee ESPAC-1
Polus, Marc ULg; Jerusalem, Guy ULg; Sautois, Brieuc ULg et al

in Revue Médicale de Liège (2002), 57(2), 119-22

The prognosis of pancreatic adenocarcinoma remains poor, with a 5-year survival rate lower than 5%. Resection, the gold standard treatment, can be performed in less than 15% of patients. Following surgery ... [more ▼]

The prognosis of pancreatic adenocarcinoma remains poor, with a 5-year survival rate lower than 5%. Resection, the gold standard treatment, can be performed in less than 15% of patients. Following surgery, the median survival is 12 months for the most favourable cancer patients. Adjuvant treatment have attempted to improve results. However, chemotherapy, radiotherapy and multimodal treatments don't have demonstrated a clear advantage in controlled trials. We will discuss results of the current trials in this topic. The randomised trial of the European Study Group for Pancreatic Cancer (ESPAC) recently published in the Lancet revealed a potential benefit of adjuvant chemotherapy. A critical analysis of the publication showed, however, that definitive conclusions of this trial must be interpreted with caution. [less ▲]

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See detailA Framework for Simulation Based Design of Ship Structures
Rigo, Philippe ULg; Karr; N a SS et al

in Journal of Ship Production (2002)

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See detailA neural network model of sensitization of evoked cortical responses in migraine
Thomas, E.; Sandor, P. S.; Ambrosini, A. et al

in Cephalalgia : An International Journal of Headache (2002), 22(1), 48-53

Migraine patients show abnormalities of cerebral electrophysiology that manifest themselves mainly during the attack interval. Cortical-evoked potentials of migraineurs fail to habituate to repetitive ... [more ▼]

Migraine patients show abnormalities of cerebral electrophysiology that manifest themselves mainly during the attack interval. Cortical-evoked potentials of migraineurs fail to habituate to repetitive presentations of visual stimuli, and the amplitude of components of their auditory cortical-evoked potentials have a higher dependence on the stimulus intensities than in healthy subjects. A computer model of a neural hetwork has been developed that is able to reproduce both these neurophysiological dysfunctions. It predicts a positive correlation between the magnitudes of both these dysfunctions. The model also offers an explanation of why mutations in the same ion channel gene with opposite consequences on channel function, e.g. P/Q Ca2+ channels in migraine, may lead to similar electrophysiological abnormalities. [less ▲]

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See detailOverexpression of the homeobox gene HOXC8 in human prostate cancer correlates with loss of tumor differentiation
Waltregny, David ULg; Alami, Younes; Clausse, Nathalie et al

in Prostate (2002), 50(3), 162-169

BACKGROUND. Homeobox (HOX)-containing proteins have been identified as regulators controlling the coordinated expression of genes involved in development and differentiation. Recent data also suggest a ... [more ▼]

BACKGROUND. Homeobox (HOX)-containing proteins have been identified as regulators controlling the coordinated expression of genes involved in development and differentiation. Recent data also suggest a possible involvement of HOX genes in malignant transformation and/or progression. We have previously shown that HOXC8 expression was selectively turned on in human cervix cancer cells compared with normal keratinocytes, suggesting that HOXC8 may be involved in the process leading to the transformation of cervix keratinocytes [Alami et al.: Biochem Biophys Res Commun 257:738-745,1999]. METHODS. RT-PCR and in situ hybridization experiments were performed to investigate the expression and cell type localization of HOXC8 transcripts in human prostate cancer cell lines and tissues. In situ hybridization was performed with the use of an HOXC8 anti-sense digoxigenin-labeled probe to investigate HOXC8 mRNA expression in 27 prostate cancer tissue specimens. RESULTS. Out of the three human prostate cancer cell lines tested, DU-145 and PC3 but not LNCaP cells expressed detectable amount of HOXC8 transcripts. Results from in situ hybridization experiments demonstrated that HOXC8 gene was expressed mainly in malignant epithelial cells. Furthermore, the staining intensity in epithelial cells was significantly increased in high Gleason score carcinomas (scores 7-9, n = 12; labeling intensity 2 + to 3 +) compared with the one observed in low and intermediate Gleason score tumors (scores 3-6, n = 15; labeling intensity 0 and 1 +) (ANOVA test, P < 0.0001). CONCLUSIONS. Our data showing that HOXC8 overexpression is associated with the loss of tumor differentiation in human prostate cancer suggests that HOXC8 may play a role in the acquisition of the invasive and metastatic phenotype of this malignancy. (C) 2002 Wiley-Liss, Inc. [less ▲]

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See detailHypertension artérielle et artériopathie
Krzesinski, Jean-Marie ULg

in Medi-Sphere (2002)

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See detailCytokine balance in infants undergoing cardiac operation.
Hovels-Gurich, Hedwig H; Schumacher, Kathrin; Vazquez-Jimenez, Jaime F et al

in Annals of Thoracic Surgery (2002), 73(2), 601-8608-9

BACKGROUND: The control of the systemic inflammatory response taking place during cardiac operations depends on adequate antiinflammatory reaction. In this prospective study we tested the hypothesis that ... [more ▼]

BACKGROUND: The control of the systemic inflammatory response taking place during cardiac operations depends on adequate antiinflammatory reaction. In this prospective study we tested the hypothesis that cytokine balance during pediatric cardiac surgical procedures would be influenced by the patients' preoperative clinical condition, defined as hypoxemia or heart failure. METHODS: Twenty infants (median age, 8 months) with hypoxemia owing to intracardiac right-to-left shunt (group 1, n = 10) or with heart failure because of intracardiac left-to-right shunt (group 2, n = 10), scheduled for elective primary corrective operation, were enrolled. Plasma levels of the proinflammatory cytokine interleukin (IL) 6, the natural antiinflammatory cytokine IL-10, and the markers of the acute-phase response, C-reactive protein and procalcitonin, were sequentially measured before, during, and after cardiac operation up to the 10th postoperative day. The ratio of IL-10 to IL-6 levels served as a marker for the individual's antiinflammatory cytokine balance. RESULTS: Group 1 showed higher preoperative IL-6 (p < 0.001), lower IL-10 levels (p < 0.02), and lower ratio of IL-10 to IL-6 levels (p < 0.001) than group 2. Preoperative C-reactive protein and procalcitonin were not detectable. In group 1, preoperative IL-6 levels inversely correlated with preoperative oxygen saturation (Spearman correlation coefficient, -0.74, p < 0.02). During cardiopulmonary bypass, IL-6 levels were higher, whereas IL-10 and ratio of IL-10 to IL-6 levels were lower in group 1 than in group 2. In all patients, postoperative IL-6 levels were positively correlated with duration of inotropic support and serum creatinine value and inversely correlated with oxygenation index and diuresis. CONCLUSIONS: Infants with hypoxemia show a preoperative inflammatory state with low antiinflammatory cytokine balance in contrast to those with heart failure. This in turn is associated with lower perioperative antiinflammatory cytokine balance and might contribute to postoperative morbidity. [less ▲]

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See detailInfluence of daily regimen calcium and vitamin D supplementation on parathyroid hormone secretion
Reginster, Jean-Yves ULg; Zegels, Brigitte ULg; Lejeune, Emmanuelle ULg et al

in Calcified Tissue International (2002), 70(2), 78-82

Calcium and vitamin D supplementation has been shown to reduce secondary hyperparathyroidism and play a role in the management of senile osteoporosis. In order to define the optimal regimen of calcium and ... [more ▼]

Calcium and vitamin D supplementation has been shown to reduce secondary hyperparathyroidism and play a role in the management of senile osteoporosis. In order to define the optimal regimen of calcium and vitamin D supplementation to produce the maximal inhibition of parathyroid hormone secretion, we have compared the administration of a similar amount of Ca and vitamin D, either as a single morning dose or split in two doses, taken 6 hours apart. Twelve healthy volunteers were assigned to three investigational procedures, at weekly intervals. After a blank control procedure, when they were not exposed to any drug intake, they received two calcium-vitamin D supplement regimens including either two doses of Orocal D3 (500 mg Ca and 400 IU vitamin D) 6 hours apart or one water-soluble effervescent powder pack of Cacit D3 in a single morning dose (1000 mg Ca and 880 IU vitamin D). During the three procedures (control and the two calcium-vitamin D supplementations), venous blood was drawn every 60 minutes for up to 9 hours, for serum Ca and serum PTH measurements. The order of administration of the two Ca and vitamin D supplementation sequences was allocated by randomization. No significant changes in serum Ca were observed during the study. During the 6 hours following Ca and vitamin D supplementation, a statistically significant decrease in serum PTH was observed with both regimens, compared with baseline and with the control procedure. Over this period of time, no differences were observed between the two treatment regimens. However, between the sixth and the ninth hour, serum PTH levels were still significantly decreased compared with baseline with split dose Orocal D3 administration, while they returned to baseline value with the Cacit D3 preparation. During this period, the percentage decrease in serum PTH compared with baseline was significantly more pronounced with Orocal D3 than with Cacit D3 (P = 0.0021). We therefore conclude that the administration of two doses of 500 mg of calcium and 400 IU of vitamin D3 6 hours apart provides a more prolonged decrease in serum PTH levels than the administration of the same total amount of Ca and vitamin D as a single morning dose in young healthy volunteers. This might have implications in terms of protection of the skeleton against secondary hyperparathyroidism and increased bone resorption and turnover in elderly subjects. [less ▲]

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See detailComparison of Rational-Based and Rule-Based Optimum Design of Ship Structures
Karr, Dale; Rigo, Philippe ULg; Na, SS et al

in SNAME Transactions (2002)

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See detailAdministration of a supplement containing both calcium and vitamin D is more effective than calcium alone to reduce secondary hyperparathyroidism in postmenopausal women with low 25(OH)vitamin D circulating levels
Deroisy, Rita ULg; Collette, Julien ULg; Albert, Adelin ULg et al

in Aging Clinical & Experimental Research (2002), 14(1), 13-17

Background and aims: Supplementation of postmenopausal women with calcium alone or calcium-vitamin D association was suggested to have positive effects on bone turnover and bone density, as well as to ... [more ▼]

Background and aims: Supplementation of postmenopausal women with calcium alone or calcium-vitamin D association was suggested to have positive effects on bone turnover and bone density, as well as to lower fracture incidence. The beneficial effect appears to be mediated by a reduction in parathyroid hormone secretion. Our aim was to compare the respective efficacy of calcium and calcium-vitamin D supplements in reducing serum parathyroid hormone levels in postmenopausal women with prevalent low 25(OH)vitamin D levels. Methods: One hundred consecutive ambulatory postmenopausal women with serum 25(OH)vitamin D levels below 18 ng/mL were included in a randomized, prospective, open label study. For a duration of 90 days, the women were randomly assigned to a daily supplementation of either one tablet of calcium gluconolactate and carbonate (500 mg calcium), or one powder-pack of an association of calcium carbonate (500 mg calcium), citric acid (2.175 gr) and cholecalciferol (200 IU). Changes observed during the 90 days of the study in circulating PTH levels were the primary endpoint, while changes in serum 25(OH)D levels were assessed as secondary endpoint. Results: A significant difference was observed between the calcium-vitamin D (CaD) and the calcium (Ca) only groups for changes occurring during the 90 days of the study in PTH (-14.5 +/- 40% and +2.5 +/- 46%) (p=0.009) and 25(OH)D (+67 +/- 77% and +18 +/- 55%) (p<0.001) circulating levels. PTH changes between baseline and day 90 were significant in the CaD group, but not in the Ca group. The odds ratio for a patient in group Ca to experience an absolute (<12 ng/mL) deficiency in circulating 25(OH)vitamin D levels, compared to a group CaD patient was statistically increased (OR: 3.22, 95% CI: 1.33-7.80). Conclusions: Our results support the recommendation of supplementing postmenopausal women with low circulating levels of 25(OH)vitamin D with a combination of calcium and vitamin D, rather than with calcium alone. [less ▲]

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See detailSpermine induces precocious development of the spleen in mice
Jolois, Olivier ULg; Peulen, Olivier ULg; Collin, Serge ULg et al

in Experimental Physiology (2002), 87(1), 69-75

Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When it is administered orally to suckling rats, it induces maturation of the intestinal tract (liver ... [more ▼]

Spermine is a low molecular weight polyamine involved in the postnatal maturation of the gut. When it is administered orally to suckling rats, it induces maturation of the intestinal tract (liver, pancreas and small intestine). Here we show that this polyamine is able to induce precocious intestinal and splenic development in suckling mice. In fact, in 15-day-old mice which had received spermine orally twice daily for 3 days we observed an increase in the ratio of white pulp surface to total spleen surface in comparison with untreated mice. The two macrophage subsets of the marginal zone and the B-cell population were more developed and reached the development level of 5- or 10-week-old mice. The proliferation rate of B-cells was increased by spermine administration to pups. These observations suggest that spermine might play a role in immune system development; further investigation of its effects are intended, namely the evaluation of its capacity to enhance defence during the neonatal period. [less ▲]

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See detailPrise en charge perioperatoire des pertes sanguines au cours du traitement chirurgical des craniostenoses
BONHOMME, Vincent ULg; Damas, François ULg; Born, J. D. et al

in Annales Françaises d'Anesthésie et de Réanimation (2002), 21(2), 119-25

Blood saving is the major challenge during the surgical repair of craniofacial deformities. Treated patients have a low reserve volume and the techniques available to lower homologous blood transfusions ... [more ▼]

Blood saving is the major challenge during the surgical repair of craniofacial deformities. Treated patients have a low reserve volume and the techniques available to lower homologous blood transfusions are limited or insufficiently evaluated in this particular case. The most important factor determining blood loss is the quality of the surgical haemostasis. Blood saving begins with early preoperative evaluation of the patient's bleeding risk, which is a function of the type of surgery, of the surgical technique, of the number of sutures involved, of the length of surgery, and of the patients age, weight and physical status. Elaborated blood saving techniques such as preoperative autologous blood donation, erythropoietin administration, normovolaemic haemodilution, and peroperative autologous blood saving and reinfusion have revealed disappointing where used alone. These techniques require a heavy setup and still need to be evaluated extensively. They should be used in selected cases such as in patients with a very high risk of bleeding or face to Jehovah Witnesses. Monitoring during surgery should include precise evaluation of blood losses and haematocrit measurements at regular intervals. The haematocrit threshold allowing homologous blood transfusion should be set at 21%, provided that any other source of autologous blood is exhausted. Postoperative monitoring should also include precise evaluation of blood losses and haematocrit measurements. The 21% threshold should remain the reference during that period. [less ▲]

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See detailThe pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent
Devy, L.; Blacher, Silvia ULg; Grignet-Debrus, Christine ULg et al

in FASEB Journal (2002), 16(2), 147-54

Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis. We previously demonstrated in vivo that this inhibitor is necessary for ... [more ▼]

Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis. We previously demonstrated in vivo that this inhibitor is necessary for optimal tumor invasion and vascularization. We also showed that PAI-1 angiogenic activity is associated with its control of plasminogen activation but not with the regulation of cell-matrix interaction. To dissect the role of the various components of the plasminogen activation system during angiogenesis, we have adapted the aortic ring assay to use vessels from gene-inactivated mice. The single deficiency of tPA, uPA, or uPAR, as well as combined deficiencies of uPA and tPA, did not dramatically affect microvessel formation. Deficiency of plasminogen delayed microvessel outgrowth. Lack of PAI-1 completely abolished angiogenesis, demonstrating its importance in the control of plasmin-mediated proteolysis. Microvessel outgrowth from PAI-1(-/-) aortic rings could be restored by adding exogenous PAI-1 (wild-type serum or purified recombinant PAI-1). Addition of recombinant PAI-1 led to a bell-shaped angiogenic response clearly showing that PAI-1 is proangiogenic at physiological concentrations and antiangiogenic at higher levels. Using specific PAI-1 mutants, we could demonstrate that PAI-1 promotes angiogenesis at physiological (nanomolar) concentrations through its antiproteolytic activity rather than by interacting with vitronectin. [less ▲]

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See detailSexually dimorphic activation of galanin neurones in the ferret's dorsomedial preoptic area/anterior hypothalamus after mating
Bakker, Julie ULg; Woodley, S. K.; Kelliher, K. R. et al

in Journal of Neuroendocrinology (2002), 14(2), 116-125

Male ferrets in breeding condition possess three times as many galanin-immunoreactive (IR) neurones as oestrous females in the sexually dimorphic dorsomedial preoptic area/anterior hypothalamus (dmPOA/AH ... [more ▼]

Male ferrets in breeding condition possess three times as many galanin-immunoreactive (IR) neurones as oestrous females in the sexually dimorphic dorsomedial preoptic area/anterior hypothalamus (dmPOA/AH). Using Fos-IR as a marker of activation, we investigated whether mating with intromission differentially activates this sexually dimorphic group of galanin-IR neurones in male and female ferrets. Male ferrets that intromitted had a significantly greater percentage of galanin-IR neurones in the dmPOA/AH that were colabelled with nuclear Fos-IR than oestrous females that received an intromission. Intromissive stimulation augmented Fos-IR in an equal percentage of galanin-IR neurones in both sexes in the medial amygdala (MA) and bed nucleus of the stria terminalis (BNST). Peripheral anosmia induced by bilateral occlusion of males' nares did not reduce the mating-induced activation of galanin-IR neurones in the dmPOA/AH, and there was a significant correlation among individual males between intromission duration and the percentage of dmPOA/AH galanin-IR neurones colabelled with Fos-IR. Exposure of castrated, testosterone propionate-treated male ferrets to either soiled bedding or to volatile odours from oestrous females failed to induce nuclear Fos-IR in galanin-IR neurones located in the dmPOA/AH, BNST or MA, suggesting that the mating-induced activation of galanin-IR forebrain neurones in male ferrets depends more on genital-somatosensory than on olfactory inputs. The observed sex dimorphism in the mating-induced activation of galanin-IR neurones in the dmPOA/AH raises the possibility that these neurones perform a mating-dependent function that occurs only in males. [less ▲]

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See detailEffect of intermittent and continuous exposure to electromagnetic fields on cultured hippocampal cells
Boland, André ULg; Gabriel, Danielle ULg; Breeur, Danielle ULg et al

in Bioelectromagnetics (2002), 23(2), 97-105

This study was designed to assess the effect of 50 Hz electromagnetic fields (EMFs) on hippocampal cell cultures in the presence or absence of either sodium nitroprusside (SNP, a NO donor) or Fe2+ induced ... [more ▼]

This study was designed to assess the effect of 50 Hz electromagnetic fields (EMFs) on hippocampal cell cultures in the presence or absence of either sodium nitroprusside (SNP, a NO donor) or Fe2+ induced oxidative stress. One week old cultured rat hippocampal cells were exposed to either intermittent EMFs (IEMFs, 50 Hz, 0-5 mT, 1 min ON/OFF cycles, repeated 10 times every 2 h, 6 times/day during 48 h) or continuous EMFs (CEMFs, 50 Hz, 0-5 mT for 48 h). In a second set of experiments, the effect on such EMFs applied in combination with oxidative stress induced by 0.5 microM Fe2+ or SNP was estimated. At the end of both sets of experiments, cell mortality was assessed by lactate dehydrogenase measurements (LDH). Neither type of exposure to EMFs was observed to modify the basal rate of cell mortality. The exposure to CEMFs in presence of either NO or Fe2+ did not induce any significant increase in cell death. However, when cells were exposed to EMFs in the presence of NO, we observed a significant increase in cell death of 11 and 23% (P<0.001) at 2.5 and 5 mT, respectively. This effect had some specificity because IEMFs did not modify the effect of Fe2+ on cell mortality. Although the effects of IEMFs reported in this study were only observed at very high intensities, our model may prove valuable in trying to identify one cellular target of EMFs. [less ▲]

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See detailInfluence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepithelial lesions of the cervix
Giannini, Sandra ULg; Hubert, Pascale ULg; Doyen, Jean ULg et al

in International Journal of Cancer = Journal International du Cancer (2002), 97(5), 654-659

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See detailPhysical interpretation of the proper orthogonal modes using the singular value decomposition
Kerschen, Gaëtan ULg; Golinval, Jean-Claude ULg

in Journal of Sound & Vibration (2002), 249(5), 849-865

Proper orthogonal decomposition is a statistical pattern analysis technique for finding the dominant structures, called the proper orthogonal modes, in an ensemble of spatially distributed data. While the ... [more ▼]

Proper orthogonal decomposition is a statistical pattern analysis technique for finding the dominant structures, called the proper orthogonal modes, in an ensemble of spatially distributed data. While the proper orthogonal modes are obtained through a statistical formulation, they can be physically interpreted in the field of structural dynamics. The purpose of this paper is thus to provide some insights into the physical interpretation of the proper orthogonal modes using the singular value decomposition. (C) 2002 Academic Press. [less ▲]

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See detailTwo-step backbiting reaction in the ring-opening polymerization of gamma-acryloyloxy-epsilon-caprolactone initiated with aluminium isopropoxide
Lou, Xudong; Detrembleur, Christophe ULg; Lecomte, Philippe ULg et al

in Macromolecular Rapid Communications (2002), 23(2), 126-129

gamma-Acryloyloxyethyl-gamma-butyrolactone is formed as a byproduct when the polymerization of gamma-acryloyloxy-epsilon-caprolactone is initiated with aluminium isopropoxide in toluene. The extent of ... [more ▼]

gamma-Acryloyloxyethyl-gamma-butyrolactone is formed as a byproduct when the polymerization of gamma-acryloyloxy-epsilon-caprolactone is initiated with aluminium isopropoxide in toluene. The extent of this side reaction decreases with decreasing temperature and is dependent on whether the reaction is stopped as soon as monomer conversion is complete or not. A two-step backbiting mechanism is proposed for this intramolecular transesterification reaction. [less ▲]

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See detailInduction of protective immunity to bovine herpesvirus type 1 in cattle by intranasal administration of replication-defective human adenovirus type 5 expressing glycoprotein gC or gD
Gogev, S.; Vanderheijden, N.; Lemaire, Mylène et al

in Vaccine (2002), 20(9-10), 1451-1465

Replication-defective human adenoviruses type 5 (HAd5) expressing the bovine herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human cytomegalovirus immediate-early promoter ... [more ▼]

Replication-defective human adenoviruses type 5 (HAd5) expressing the bovine herpesvirus type 1 (BHV-1) glycoprotein gC or gD under the control of the human cytomegalovirus immediate-early promoter/enhancer (AdCMVgC or AdCMVgD) or the 5' regulatory region of the human desmin gene (AdDESMgC or AdDESMgD) were generated. A preliminary experiment performed on rabbits showed that the intranasal administration of AdCMV elicited higher levels of BHV-1 neutralizing antibodies than the intramuscular administration of AdDESM. The obtained results allowed to select the replication-defective AdCMVgC and AdCMVgD for further assessment of their potential as a recombinant vaccine in cattle. Calves were injected intranasally twice 3 weeks apart with either AdCMVgC or AdCMVgD or a combination of these two recombinants or a commercially available live vaccine for comparison. The highest BHV-1 neutralizing antibody titres were obtained with AdCMVgD followed by the live vaccine and to a lower extent with the combination of the two recombinants (AdCMVgC+AdCMVgD). Calves were protected against intranasal BHV-1 challenge performed 3 weeks after the second immunization. In view of the obtained results, recombinant HAd5 may be developed as an intranasal vaccine vector in cattle administrated either alone or sequentially with non-human adenovirus-based vectors. [less ▲]

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See detailHistone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
Deroanne, Christophe ULg; Bonjean, Karine; Servotte, Sandrine et al

in Oncogene (2002), 21(3), 427-436

Angiogenesis is a complex biological process involving the coordinated modulation of many genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the availability of chromatin to ... [more ▼]

Angiogenesis is a complex biological process involving the coordinated modulation of many genes. Histone deacetylases (HDAC) are a growing family of enzymes that mediate the availability of chromatin to the transcriptional machinery. Trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA), two HDAC inhibitors known to relieve gene silencing, were evaluated as potential antiangiogenic agents. TSA and SAHA were shown to prevent vascular endothelial growth factor (VEGF)-stimulated human umbilical cord endothelial cells (HUVEC) from invading a type I collagen gel and forming capillary-like structures. SAHA and TSA inhibited the VEGF-induced formation of a CD31-positive capillary-like network in embryoid bodies and inhibited the VEGF-induced angiogenesis in the CAM assay. TSA also prevented, in a dose-response relationship, the sprouting of capillaries from rat aortic rings. TSA inhibited in a dose-dependent and reversible fashion the VEGF-induced expression of VEGF receptors, VEGFR1, VEGFR2, and neuropilin-1. TSA and SAHA upregulated the expression by HUVEC of semaphorin III, a recently described VEGF competitor, at both mRNA and protein levels. This effect was specific to endothelial cells and was not observed in human fibroblasts neither in vascular smooth muscle cells. These observations provide a conspicuous demonstration that HDAC inhibitors are potent anti-angiogenic factors altering VEGF signaling. [less ▲]

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See detailAutomated determination of pirlindole enantiomers in plasma by on-line coupling of a pre-column packed with restricted access material to a chiral liquid chromatographic column
Chiap, Patrice ULg; Ceccato, Attilio ULg; Gora, R. et al

in Journal of Pharmaceutical & Biomedical Analysis (2002), 27(3-4), 447-455

A fully automated liquid chromatographic method has been developed for the determination of the enantiomers of pirlindole, an antidepressant drug, in human plasma. The method is based on the use of a pre ... [more ▼]

A fully automated liquid chromatographic method has been developed for the determination of the enantiomers of pirlindole, an antidepressant drug, in human plasma. The method is based on the use of a pre-column packed with restricted access material (RAM) (LiChrospher ADS RP-4) for sample clean-up coupled to a column containing a cellulose tris-(3,5-dimethylphenylcarbamate) based chiral stationary phase (Chiralcel OD-R) for the separation and quantitative analysis of pirlindole enantiomers. A 50-microl plasma volume was injected directly onto the pre-column using a mixture of phosphate buffer (pH 5.0) and methanol (97:3; v/v) as washing liquid. By rotation of a switching valve, the analytes were then eluted in the back-flush mode with the LC mobile phase. A complete separation of pirlindole enantiomers was obtained in 22 min on the Chiralcel OD-R column, using a mobile phase made of a mixture of phosphate buffer (pH 5.0) containing 50 mM sodium perchlorate and acetonitrile (65:35; v/v). The flow-rate was 0.6 ml/min and the analytes were detected fluorometrically using 295 and 340 nm as excitation and emission wavelengths, respectively. The method was then validated and was found to be linear in the 2.5-200 ng/ml range. The limit of detection was lower than 1 ng/ml. Repeatability and intermediate precision at a concentration of 50 ng/ml were about 1.5 and 3.5%, respectively. [less ▲]

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See detailThe impact of enantioseparation techniques on the development and use of chiral drugs - Preface
Chankvetadze, B.; Crommen, Jacques ULg

in Journal of Pharmaceutical & Biomedical Analysis (2002), 27(3-4), 355-355

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See detailMatrix and serine protease expression during leukemic cell differentiation induced by aclacinomycin and all-trans-retinoic acid
Devy, L.; Hollender, P.; Munaut, Carine ULg et al

in Biochemical Pharmacology (2002), 63(2), 179-189

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and ... [more ▼]

In myeloid leukemia, immature leukemic cells are able to egress into peripheral blood to infiltrate extra-medullary organs. We therefore analyzed the migrating and invasive potential of human HL-60 and NB4 cell lines, representative of acute myelogenous leukemia, their ability to express matrix metalloproteases (MMPs), tissue inhibitors of metalloproteases (TIMPs) and urokinase plasminogen activator (uPA) in response to differentiating agents. Granulocytic differentiation by all-trans-retinoic acid (ATRA) and aclacinomycin (ACLA) strongly increased HL-60 and NB4 cell migration and invasion. At mRNA and protein levels, these cell lines produced significant amounts of MMP-9 (HL-60 < NB4). Granulocytic differentiation by ACLA increased both pro and active forms of MMP-9 whereas ATRA decreased them and stimulated uPA mRNAs. TIMP-1, the physiological MMP inhibitor, increased during granulocytic differentiation whereas TIMP-2 did not significantly vary. Use of Batimastat and aprotinin suggests that ATRA was active by modulating the uPA system while ACLA interfered with MMP expression. In conclusion, our data demonstrate that HL-60 and NB4 cells express MMPs and uPA which are differentially regulated by the differentiating agents ATRA and ACLA and suggest the clinical usefulness of MMPs and serine protease inhibitors in the prophylaxis and treatment of the ATRA syndrome. (C) 2002 Elsevier Science Inc. All rights reserved. [less ▲]

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See detailNear-infrared [Fe II] emission from supernova remnants and the supernova rate of starburst galaxies
Morel, Thierry ULg; Doyon, R.; St-Louis, N.

in Monthly Notices of the Royal Astronomical Society (2002), 329

In an effort better to calibrate the supernova rate of starburst galaxies as determined from near-infrared [FeII] features, we report on a [FeII] λ1.644μm line-imaging survey of a sample of 42 optically ... [more ▼]

In an effort better to calibrate the supernova rate of starburst galaxies as determined from near-infrared [FeII] features, we report on a [FeII] λ1.644μm line-imaging survey of a sample of 42 optically selected supernova remnants (SNRs) in M33. A wide range of [FeII] luminosities are observed within our sample (from less than 6 to 695L[SUB]solar[/SUB]). Our data suggest that the bright [FeII] SNRs are entering the radiative phase and that the density of the local interstellar medium (ISM) largely controls the amount of [FeII] emission. We derive the following relation between the [FeII] λ1.644μm line luminosity of radiative SNRs and the electronic density of the post-shock gas, n[SUB]e[/SUB]: L[SUB][FeII][/SUB] (L[SUB]solar[/SUB])~1.1n[SUB]e[/SUB] (cm[SUP]-3[/SUP]). We also find a correlation in our data between L[SUB][FeII][/SUB] and the metallicity of the shock-heated gas, but the physical interpretation of this result remains inconclusive, as our data also show a correlation between the metallicity and n[SUB]e[/SUB]. The dramatically higher level of [FeII] emission from SNRs in the central regions of starburst galaxies is most likely due to their dense environments, although metallicity effects might also be important. The typical [FeII]-emitting lifetime of a SNR in the central regions of starburst galaxies is found to be of the order of 10[SUP]4[/SUP]yr. On the basis of these results, we provide a new empirical relation allowing the determination of the current supernova rate of starburst galaxies from their integrated near-infrared [FeII] luminosity. [less ▲]

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See detailAcute traumatic central cord syndrome: magnetic resonance imaging and clinical observations
Collignon, F. D.; Martin, Didier ULg; Lenelle, Jacques ULg et al

in Journal of Neurosurgery (2002), 96(1 Suppl), 29-33

Object. Acute traumatic central cord syndrome has been classically thought to be caused by a hemorrhage that primarily affects the central part of the spinal cord and that destroys the axons of the inner ... [more ▼]

Object. Acute traumatic central cord syndrome has been classically thought to be caused by a hemorrhage that primarily affects the central part of the spinal cord and that destroys the axons of the inner part of the corticospinal tract devoted to the motor control of the hands. Some authors, however, have proposed that its pathogenesis is based on the destruction of the motor neurons supplying the muscles of the hand. To test the validity of these two theories, the authors retrospectively studied the magnetic resonance (MR) images obtained in 18 cases of acute traumatic central cord syndrome (ATCCS) to assess the presence of intramedullary blood and to define the distribution of the abnormal signal intensities in the cervical spinal cord. Methods. The authors used the American Spinal Injury Association (ASIA) motor scale to assess upper- and lower-limb deficits and to evaluate its metameric distribution. The abnormal intramedullary signal was then compared with the distribution of the motor deficit. All MR imaging sessions performed in the acute stage revealed a hyperintense signal on T-2-weighted sequences without any signal change suggesting the presence of intramedullary blood. The localization of this signal was distributed predominantly from the C3-4 to the C5-6 disc levels. The mean ASIA motor score was 74.3 of 100, with an unequal representation between the upper and lower limbs (32 of 50 compared with 42.3 of 50, respectively). The metameric distribution of the deficit was also unequal, with a major deficit in hand function (C8-T1) compared with the more proximal cord segments (5.2 of 10 compared with 7.8 of 10, respectively). This demonstrates the absence of any correlation between the hyperintense signal and the motor deficit distribution. Conclusions. Acute traumatic central cord syndrome cannot be explained by the injury to the gray matter at the level of motor neurons supplying the hand muscles. In agreement with recently published data, the results of this series confirm the absence of intramedullary hemorrhage and corroborate the hypothesis that ATCCS may be explained by the impairment of the corticospinal tract, which can be affected globally. [less ▲]

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See detailEstablishment of a geographic data dictionnary : a case study of UrbIS 2 ©, the Brussels regional government GIS
Pantazis, Dimos; Cornélis, Bernard; Billen, Roland ULg et al

in Computers, Environment & Urban Systems (2002), 26(1), 3-17

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See detailPharma-clinics le medicament du mois. Le rabeprazole (Pariet)
Louis, Edouard ULg

in Revue Médicale de Liège (2002), 57(1), 53-6

Proton pomp inhibitors (PPI) have revolutionized the treatment of gastro-oesophageal reflux disease and gastro-duodenal ulcers. Rabeprazole (Pariet) is the last PPI arrived on the Belgian market ... [more ▼]

Proton pomp inhibitors (PPI) have revolutionized the treatment of gastro-oesophageal reflux disease and gastro-duodenal ulcers. Rabeprazole (Pariet) is the last PPI arrived on the Belgian market. Controlled studies have shown an efficacy similar to emeprazole in the treatment of oeso-gastro-duodenal acid diseases. Rabeprazole has a favourable profile with rapid action and good safety. [less ▲]

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See detailS-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism
Locigno, Roberto; Pincemail, Joël ULg; Henno, Audrey et al

in International Journal of Oncology (2002), 20(1), 69-75

Reduced apoptosis is associated to cancer development. Agents able to restore the programmed cell death responsiveness of cancer cells are foreseen as potential effective cancer therapies. In this study ... [more ▼]

Reduced apoptosis is associated to cancer development. Agents able to restore the programmed cell death responsiveness of cancer cells are foreseen as potential effective cancer therapies. In this study, we report that a glutathione-S-derivative, S-acetyl-glutathione (Sag), induces significant apoptosis in three human lymphoma cell lines, including Daudi, Raji and Jurkat cells while it had no or little effect on either Hut-78 lymphoma cells or the normal BT lymphocytes. We used Annexin-V FACS analysis and DNA laddering to demonstrate that Sag activated apoptosis in the three sensitive cell lines in a dose- and time-dependent-fashion. Using mercury orange staining and FACS analysis, we showed that Sag generated an intracellular GSH depletion in Daudi, Raji and Jurkat cells but not in Hut-78 or the normal BT cells. These data provide direct evidence that Sag specifically activates programmed cell death in lymphoma cells through, at least in part, a depletion of intracellular GSH rather than an increase, as previously suggested. Because of its selective effect on cancer cells, Sag appears as a promising new lymphoma cell apoptosis inducer with potential clinical value for lymphoma patients. [less ▲]

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See detailLe gigantisme: un mystère élucidé
Beckers, Albert ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2002), 157(1-2), 111-7117-9

Acromegaly was first described by Pierre Marie in 1886. Some years later, it became clear that acromegaly and gigantism share the same etiology: GH hypersecretion due to a pituitary adenoma, induces ... [more ▼]

Acromegaly was first described by Pierre Marie in 1886. Some years later, it became clear that acromegaly and gigantism share the same etiology: GH hypersecretion due to a pituitary adenoma, induces gigantism if already present during puberty, or an acromegalic if it appears only during the adulthood. During the XXth century, the disease has been well described and is now well controlled with several treatments. Recently, genetic alterations responsible for the disease have been elucidated. [less ▲]

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See detailLa restauration du maillage écologique: une nécessité pour assurer la conservation de l'herpétofaune en Wallonie
Graitson, Eric ULg; Jacob, Jean-Paul

in Natura Mosana (2002), 54(4), 21-36

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See detailEfficacy of the new long-acting formulation of lanreotide (lanreotide Autogel) in the management of acromegaly.
Caron, Ph; Beckers, Albert ULg; Cullen, C. R. et al

in Journal of Clinical Endocrinology and Metabolism (2002), 87(1), 99-104

Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this ... [more ▼]

Lanreotide Autogel is a new long-acting aqueous preparation of lanreotide for the treatment of acromegaly and is administered by deep sc injection from a small volume, prefilled syringe. The aim of this study was to evaluate the efficacy and safety of this new long-acting formulation in a large population of acromegalic patients previously responsive to lanreotide 30 mg, im (sustained release microparticle formulation). Lanreotide Autogel was administered by deep sc injection every 28 d to 107 patients (54 males and 53 females; mean age, 54 +/- 1.2 yr). All patients had been treated with lanreotide (30 mg) for at least 3 months before study entry and had a mean GH level less than 10 ng/ml after at least 4 subsequent im injections every 14 d (48%), 10 d (32%), or 7 d (20%). Treatment was switched from lanreotide 30 mg injected every 14, 10, or 7 d to 60, 90, or 120 mg lanreotide Autogel, respectively, every 28 d. After three fixed dose injections of lanreotide Autogel, mean lanreotide levels were similar to those obtained at steady state with lanreotide 30 mg. During lanreotide Autogel treatment, the control of acromegalic symptoms was comparable with that previously achieved during lanreotide 30 mg treatment. After 3 injections of lanreotide Autogel, mean GH (2.87 +/- 0.22 ng/ml) and IGF-I (317 +/- 15 ng/ml) values were comparable with those recorded at the end of lanreotide 30 mg treatment (GH, 2.82 +/- 0.19 ng/ml; IGF-I, 323 +/- 16 ng/ml). GH levels below 2.5 ng/ml and age-/sex-normalized IGF-I were achieved in 33% and 39% of patients during lanreotide 30 mg and lanreotide Autogel treatment, respectively. Diarrhea, abdominal pain, and nausea were reported by 38%, 22%, and 18% of patients during lanreotide 30 mg treatment and by 29%, 17%, and 9% of patients, respectively, during lanreotide Autogel treatment. In conclusion, this clinical study shows that lanreotide Autogel is at least as efficacious and well tolerated as lanreotide 30 mg. This new long-acting lanreotide formulation, lanreotide Autogel, which is administered from a small volume, prefilled syringe by deep sc injection, is therefore likely to improve the acceptability of medical treatment for patients requiring long-term somatostatin analog therapy. [less ▲]

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See detailThe crystal chemistry of lithium in the alluaudite structure: A study of the (Na1-xLix)Cdln(2) (PO4)(3) the solid solution (x=0 to 1)
Hatert, Frédéric ULg; Antenucci, Diano ULg; Fransolet, André-Mathieu ULg et al

in Journal of Solid State Chemistry (2002), 163(1), 194-201

Several compounds of the (Na1-xLix)CdIn2(PO4)(3) solid solution were synthesized by a solid-state reaction in air, and pure alluaudite-like compounds were obtained for x = 0.00, 0.25, and 0.50. X-ray ... [more ▼]

Several compounds of the (Na1-xLix)CdIn2(PO4)(3) solid solution were synthesized by a solid-state reaction in air, and pure alluaudite-like compounds were obtained for x = 0.00, 0.25, and 0.50. X-ray Rietveld refinements indicate the occurrence of Cd2+ in the M(1) site, and of In3+ in the M(2) site of the alluaudite structure. This non-disordered cationic distribution is confirmed by the sharpness of the infrared absorption bands. The distribution of Na+ and Li+ on the A(1) and A(2)' crystallographic sites cannot be accurately assessed by the Rietvled method, probably because the electronic densities involved in the Na+ --> Li+ substitution are very small. A comparison with the synthetic alluaudite-like compounds, (Na1-xLix)MnFe2(PO4)(3), indicates the influence of the cations occupying the M(1) and M(2) sites on the coordination polyhedra morphologies of the A(1) and A(2)' crystallographic sites. (C) 2002 Elsevier Science. [less ▲]

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See detailA colorimetric method for the determination of lipase activity in soil
Margesin, R.; Feller, Georges ULg; Hammerle, M. et al

in Biotechnology Letters (2002), 24(1), 27-33

A colorimetric method for the determination of lipase activity in soil has been developed. Using p-nitrophenyl butyrate as substrate, soil samples are incubated at 30 degreesC and pH 7.25 for 10 min ... [more ▼]

A colorimetric method for the determination of lipase activity in soil has been developed. Using p-nitrophenyl butyrate as substrate, soil samples are incubated at 30 degreesC and pH 7.25 for 10 min. After cooling on ice and centrifugation, the released p-nitrophenol is determined at 400 nm. To allow for the adsorption of p-nitrophenol onto soil, a calibration curve is prepared in the presence of soil. [less ▲]

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See detailSport-études : Comparaison des caractéristiques motivationnelles et des relations sociales des élèves sportifs et de leurs condisciples
Cloes, Marc ULg; Schelings, Virginie; Ledent, Maryse ULg et al

in e Journal de la Recherche sur l'Intervention en Education Physique et Sport (2002), 1

Le sport-études a été créé afin de permettre aux jeunes ayant de bonnes dispositions sportives de les développer dans le cadre d’un programme intégré à leur formation scolaire. Si les modalités pratiques ... [more ▼]

Le sport-études a été créé afin de permettre aux jeunes ayant de bonnes dispositions sportives de les développer dans le cadre d’un programme intégré à leur formation scolaire. Si les modalités pratiques diffèrent largement d’une structure à l’autre selon la législation en vigueur, les sportifs sont inévitablement confrontés à des problèmes communs. Bizarrement, peu d’études semblent s’y être intéressées. Par ailleurs, les élèves qui partagent la formation scolaire des sportifs constituent un groupe auquel il n’est jamais fait référence. [less ▲]

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See detailContribution of unsymmetrical difunctional initiators/monomers to the macromolecular engineering
Jérôme, Robert ULg

in Macromolecular Symposia (2002), 177

The emerging technologies (e.g. in optics, microelectronics, medicine...) require the availability of synthetic polymers with continuously more sophisticated properties and performances. The best way for ... [more ▼]

The emerging technologies (e.g. in optics, microelectronics, medicine...) require the availability of synthetic polymers with continuously more sophisticated properties and performances. The best way for the polymer chemist to face this challenge is to tailor the molecular structure of the chains. Nowadays, the progress in the living/controlled polymerization mechanisms is such that the so-called macromolecular engineering is a vivid reality. [less ▲]

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See detailThe inhibition of metalloproteinases to treat osteoarthritis: reality and new perspectives
Henrotin, Yves ULg; Sanchez, Christelle ULg; Reginster, Jean-Yves ULg

in Expert Opinion on Therapeutic Patents (2002), 12(1), 29-43

The objective of this paper is to analyse the potential therapeutic action of MMP inhibitors in the management of osteoarthritis (OA), based on a critical review of the literature. The role played by ... [more ▼]

The objective of this paper is to analyse the potential therapeutic action of MMP inhibitors in the management of osteoarthritis (OA), based on a critical review of the literature. The role played by metalloproteinases (MPs) in the pathophysiology of osteoarthritis is discussed, as well as their regulation by tissular inhibitors, activators and cytokines. The evidences that commonly used drugs for treating osteoarthritis are also active on MPs synthesis is also reported. Finally, this paper provides an analysis of the recent patents published with promising therapeutic potential and gives new perspectives for anti-MPs therapy. [less ▲]

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See detailEffect of endogenous serotonin on the binding of the 5-HT1A PET ligand 18 F in the rat hippocampus: kinetic b measurements combined with microdialysis
Zimmer, Luc; Mauger, Gweltas; Le Bars, Didier et al

in Journal of Neurochemistry (2002), 80(2), 278-286

By using a combination of an original beta(+)-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of F-18-MPPF [4-(2'-methoxy-phenyl)-1-[2'-[N ... [more ▼]

By using a combination of an original beta(+)-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of F-18-MPPF [4-(2'-methoxy-phenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido]ethyl]piperazine] to the serotonin-1A (5-HT1A) receptors was investigated in the hippocampus of the anaesthetized rat. Our beta-sensitive probe prototype was sensitive enough to obtain Specific F-18-MPPF time-activity curves in the rodent (hippocampus/cerebellum ratio approximate to 2). The serotonin neuronal release was pharmacologically enhanced using fenfluramine at three different doses (1, 2 and 10 mg/kg intravenous) multiplying by 2-15 the extracellular serotonin in the hippocampus. These extracellular variations of extracellular serotonin resulted in dose-ranging decreases in F-18-MPPF-specific binding in the same rat. Our results showed for the first time that F-18-MPPF binding could be modulated by modifications of extracellular serotonin in the rat hippocampus. These results were confirmed by the enhancement of extracellular radioactivity collected in dialysates after the displacement of F-18-MPPF by fenfluramine. After modelization, F-18-MPPF binding could constitute an interesting radiotracer for positron emission tomography in evaluating the serotonin endogenous levels in limbic areas of the human brain. [less ▲]

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See detailDistribution of aromatase immunoreactivity in the forebrain of red-sided garter snakes at the beginning of the winter dormancy
Krohmer, R. W.; Bieganski, G. J.; Baleckaitis, D. D. et al

in Journal of Chemical Neuroanatomy (2002), 23(1), 59-71

Until recently, it has been difficult to identify the exact location of aromatase containing cells in the brain. The development of new antibodies has provided a sensitive tool to analyze the distribution ... [more ▼]

Until recently, it has been difficult to identify the exact location of aromatase containing cells in the brain. The development of new antibodies has provided a sensitive tool to analyze the distribution of aromatase immunoreactive (ARO-ir) material at a cellular level of resolution. In the present study we examined, for the first time, the distribution of ARO-ir cells in the brain of a reptile, the red-sided garter snake, at the beginning of the winter dormancy. ARO-ir cells were found at all rostro-caudal levels in the red-sided garter snake brain. Although weakly stained cells were distributed throughout the brain, more intensely immunoreactive cells were primarily concentrated in the preoptic area, anterior hypothalamus, septum and nucleus sphericus. Although androgens are elevated upon emergence from hibernation in the male red-sided garter snake, initiation of courtship behavior appears to be independent of direct androgen control. To date, the only known stimulus found to initiate courtship is a period of low temperature dormancy followed by exposure to warm temperatures. Circumstantial data, however, suggest an indirect role in the activation of male copulatory behavior for estrogenic metabolites of testosterone produced in the brain by aromatization during the winter dormancy. This study provides the first documentation of the distribution of ARO-ir cells in a reptilian species and demonstrates that while the aromatase enzyme occurs in most regions of the brain, the ARO-ir cells that appear to contain the highest concentration of enzyme are clustered in brain areas classically associated with the control of courtship behavior and mating in vertebrates. These data are consistent with the idea that estrogens locally produced in the brain may participate in some way to the activation of sexual behavior in this species also. This notion should now be experimentally tested by analyzing annual changes in aromatase activity and immunoreactivity and assessing the effects of pharmacological blockade of the enzyme activity at different times of the year. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEstimation of rubber sliding friction from asperity interaction modeling
Bui, Q. V.; Ponthot, Jean-Philippe ULg

in Wear (2002), 252(1-2), 150-160

Interaction between a soft rubber asperity and its hard counterpart is traced with the help of a finite element computation. The analysis is aimed to estimate the influence of adhesion between rubber and ... [more ▼]

Interaction between a soft rubber asperity and its hard counterpart is traced with the help of a finite element computation. The analysis is aimed to estimate the influence of adhesion between rubber and rigid surfaces and the energy losses arising from the deformation of rubber bulk to the sliding resistance. At the contact zone, interfacial bonds are formed due to adhesion and their resistance to sliding is represented by the shear strength of the contact interface. In the rubber bulk, the hysteresis loss is calculated using an appropriate model of the viscoelastic mechanical behavior of rubber for large strains. Dependence of friction on sliding speeds and temperature is hence detected. Influence of surface roughness and contact pressure on friction is also examined. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detail8-Chloro-6-(3-dimethylaminopropylamino)-11H-pyrido[2,3-b][1,4]benzodiazepine
Dupont, Léon ULg; Eyrolles, Laurence; Evrard, Guy et al

in Acta Crystallographica Section E-Structure Reports Online (2002), 58(Part 1), 69-71

The crystal structure determination of the title compound, C17H20ClN5, has been undertaken as part of studies on antipsychotic drugs. Its structure is compared with that of clozapine (C18H19ClN4), a well ... [more ▼]

The crystal structure determination of the title compound, C17H20ClN5, has been undertaken as part of studies on antipsychotic drugs. Its structure is compared with that of clozapine (C18H19ClN4), a well known atypical antipsychotic drug. The side chain is more flexible than in the N-methylpiperazine analogues, but its folding is influenced by an intramolecular N-H . . .N hydrogen bond. The distances between the N-distal atom, a possible pharmacophore, and the centres of the two aromatic rings are significantly shorter than in clozapine. The crystal packing involves one N-H . . .N intermolecular hydrogen bond. The title compound showed no affinity for the receptors tested. [less ▲]

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See detailUse of an Amplatzer ductal occluder to close a persistent left superior caval vein which reopened after a total cavopulmonary anastomosis.
SEGHAYE, Marie-Christine ULg; Wainwright, Uwe; von Bermuth, Gotz

in Cardiology in the Young (2002), 12(1), 81-3

A 7-year-old boy developed increasing cyanosis after a total cavopulmonary connection with a 3 mm fenestration in the baffle. Catheterisation performed 4 years and 7 months after the operation showed ... [more ▼]

A 7-year-old boy developed increasing cyanosis after a total cavopulmonary connection with a 3 mm fenestration in the baffle. Catheterisation performed 4 years and 7 months after the operation showed reopening of a left superior caval vein draining into the pulmonary venous atrium. Due to the large size of the left superior caval vein, and the absence of intrinsic stenosis, we chose to use an Amplatzer ductal device to occlude the reopened vein. The procedure was safe and successful. [less ▲]

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See detailSpace and time distributions of phosphate in the Mediterranean Sea
Karafistan, A.; Martin, J. M.; Rixen, M. et al

in Deep-Sea Research Part I, Oceanographic Research Papers (2002), 49(1), 67-82

Statistical modelling was applied to a large number of historical nutrient data to assess the significance of human perturbations in the Mediterranean Sea. All available phosphate data were grouped into ... [more ▼]

Statistical modelling was applied to a large number of historical nutrient data to assess the significance of human perturbations in the Mediterranean Sea. All available phosphate data were grouped into subsets representative of averaged values of the measured vertical profiles in the surface and deep water layers. In contrast to earlier predictions, the statistical analysis of the phosphate concentrations in a deep water layer does not indicate any particular trend in time for the last 30 years. These data sets were then used as an input to an inverse model and a 3D primitive equation model (PEM). The former redistributes the measured concentrations by means of a variational principle and reconstructs average horizontal space distributions of the phosphate data fields as gridded solutions over the whole area. The spatial and temporal distributions thus obtained are visualised graphically and compared with other existing data, providing the first overall view of phosphate in the whole Mediterranean Sea and revealing an increasing oligotrophy towards the eastern basin. The primitive equation model is then used to assess the variability and upwelling fluxes. (C) 2001 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailComparative study on the enantioseparation of glutethimide using dual cyclodextrin systems and cyclodextrin modified MEKC in capillary electrophoresis
Abushoffa, Adel M.; Burjanadze, Naira; Blaschke, Gottfried et al

in Journal of Separation Science (2002), 25(1-2), 10-16

In order to critically evaluate the potential of dual cyclodextrin (CD) systems in CE, enantioseparation of the neutral chiral analyte glutethimide (GT) was performed using: a) charged CDs; b ... [more ▼]

In order to critically evaluate the potential of dual cyclodextrin (CD) systems in CE, enantioseparation of the neutral chiral analyte glutethimide (GT) was performed using: a) charged CDs; b) combinations of charged and neutral CDs (dual CD systems), and c) CD-modified micellar electrokinetic chromatography (CD-MECK). The results of this comparative study indicate that properly designed dual CD systems may in certain cases represent a valuable alternative to CD-MEKC and electrokinetic chromatography involving charged CDs for enantioseparation of neutral analytes. [less ▲]

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See detailReversal of oxalosis cardiomyopathy after combined liver and kidney transplantation
Detry, Olivier ULg; Honore, Pierre ULg; De Roover, Arnaud ULg et al

in Transplant International (2002), 15(1), 50-52

Few data have been published on the course of oxalosis cardiomyopathy after combined liver and kidney transplantation in hyperoxaluria patients with myocardial involvement. We report the case of a primary ... [more ▼]

Few data have been published on the course of oxalosis cardiomyopathy after combined liver and kidney transplantation in hyperoxaluria patients with myocardial involvement. We report the case of a primary hyperoxaluria type I patient with renal failure who developed end-stage cardiomyopathy. Left venticulography showed severe diffuse hypokinesia and left ventricular ejection fraction was calculated at 12%. Endomyocardial biopsy demonstrated platelike calcium oxalate crystals within the myocardium and the connective tissue, and mild perivascular fibrosis. The patient was first considered for combined liver-heart-kidney transplantation, but as his cardiac function improved slightly with an intensive dialysis program, combined liver and kidney transplantation was performed. Normal cardiac function was demonstrated at 1-year follow-up, and comparative endomyocardial biopsy showed regression of the myocardial oxalate deposits. This case adds stronger clinical, hemodynamic, and histopathological evidence that severe oxalosis cardiomyopathy may be reversed after combined liver and kidney transplantation. [less ▲]

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See detailLes anomalies morphologiques et metaboliques liees aux traitements antiretroviraux
Debruyn, X.; Nkoghe, D.; Leonard, Philippe ULg et al

in Revue Médicale de Liège (2002), 57(1), 23-8

The long term use of antiretroviral therapy is associated with metabolic and morphological abnormalities named lipodystrophy. The understanding of its epidemiology is in progress. NRTIs and Pls are ... [more ▼]

The long term use of antiretroviral therapy is associated with metabolic and morphological abnormalities named lipodystrophy. The understanding of its epidemiology is in progress. NRTIs and Pls are involved in the origin of these abnormalities. So, NRTIs inhibit mitochondrial gamma polymerase and induce body fat distribution disorders. PIs interfere with lipid metabolism, leading to hyperlipidaemia and insulin resistance symptomatology. The diagnosis is made by clinical (far wasting or accumulation, or mixed syndrome) and biological signs (hyperlipidaemia, hyperglycaemia, hyperlactacidaemia). Radiological exams can quantify morphological abnormalities. The management consists in drug substitution, diet and exercise, and corrective drugs. Plastic surgery can be useful. [less ▲]

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See detailEtude clinique du mois. Effets du valsartan dans l'insuffisance cardiaque chronique: l'etude Val-HeFT
Pierard, Luc ULg

in Revue Médicale de Liège (2002), 57(1), 57-9

Current guidelines recommend drugs which reduce neurohormonal activation as standard therapy for heart failure: angiotensin converting-enzyme (ACE) inhibitors, beta-blockers and spironolactone. The ... [more ▼]

Current guidelines recommend drugs which reduce neurohormonal activation as standard therapy for heart failure: angiotensin converting-enzyme (ACE) inhibitors, beta-blockers and spironolactone. The Valsartan Heart Failure Trial (Val-HeFT) tested the efficacy of the angiotensin-receptor blocker valsartan in addition to prescribed therapy. A total of 5010 patients with heart failure of NYHA class II, III or IV were randomly assigned to receive 160 mg of valsartan or placebo twice daily. Further angiotensin antagonism by valsartan did not improve survival but was beneficial in terms of morbidity and mortality, because of reduced rate of hospitalization, significant improvements in NYHA class, ejection fraction, signs and symptoms of heart failure, and quality of life. Valsartan had highly favourable effects in patients not receiving ACE inhibitors but an adverse effect in patients receiving both ACE inhibitors and beta-blockers. The effects of adding valsartan are depending on the importance of previous neurohormonal inhibition. [less ▲]

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See detailA note on finite-sample efficiencies of estimators for the minimum volume ellipsoid
Croux, C.; Haesbroeck, Gentiane ULg

in Journal of Statistical Computation & Simulation (2002), 72(7), 585-596

Among the most well known estimators of multivariate location and scatter is the Minimum Volume Ellipsoid (MVE). Many algorithms have been proposed to compute it. Most of these attempt merely to ... [more ▼]

Among the most well known estimators of multivariate location and scatter is the Minimum Volume Ellipsoid (MVE). Many algorithms have been proposed to compute it. Most of these attempt merely to approximate as close as possible the exact MVE, but some of them led to the definition of new estimators which maintain the properties of robustness and affine equivariance that make the MVE so attractive. Rousseeuw and van Zomeren (1990) used the (p+1)- subset estimator which was modified by Croux and Haesbroeck (1997) to give rise to the averaged (p+1)- subset estimator . This note shows by means of simulations that the averaged (p+1)-subset estimator outperforms the exact estimator as far as finite-sample efficiency is concerned. We also present a new robust estimator for the MVE, closely related to the averaged (p+1)-subset estimator, but yielding a natural ranking of the data. [less ▲]

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See detailVirus neutralising antibodies against 22 bovine viral diarrhoea virus isolates in vaccinated calves
Hamers, C.; Di Valentin, Emmanuel ULg; Dumont, Chloé ULg et al

in Veterinary Journal (2002), 163(1), 61-67

Seven of nine colostrum deprived calves, free from bovine viral diarrhoea virus (BVDV), were vaccinated with a commercially available vaccine containing two inactivated strains of BVDV, an inactivated ... [more ▼]

Seven of nine colostrum deprived calves, free from bovine viral diarrhoea virus (BVDV), were vaccinated with a commercially available vaccine containing two inactivated strains of BVDV, an inactivated strain of bovine herpesvirus-1 and modified-live strains of bovine respiratory syncytial virus and para-influenza-3 virus. The two other calves were kept as controls. The virus neutralising (VN) antibodies induced by vaccination were tested against 22 antigenically diverse BVDV isolates, including reference strains and field isolates, both cytopathic and non-cytopathic, as well as genotypes I and II. The strains were isolated in Belgium, France, Germany, the United Kingdom and the USA. While there were variations in the VN titres of the individual calves against all the strains, serum from the seven animals neutralised 20 or more of the strains tested. From the results, it can be concluded that the vaccine can stimulate the production of VN antibodies capable of neutralising a wide range of European and American isolates of BVDV, including genotypes I and II. [less ▲]

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See detailEpidural administration of low-dose morphine combined with clonidine for postoperative analgesia after lumbar disc surgery
Bonhomme, Vincent ULg; Doll, Anne; Dewandre, Pierre-Yves et al

in Journal of Neurosurgical Anesthesiology (2002), 14(1), 1-6

This study evaluates the efficacy and side effects of a low dose of epidural morphine combined with clonidine for postoperative pain relief after lumbar disc surgery. In 36 of 51 patients who accepted the ... [more ▼]

This study evaluates the efficacy and side effects of a low dose of epidural morphine combined with clonidine for postoperative pain relief after lumbar disc surgery. In 36 of 51 patients who accepted the procedure, an epidural catheter was inserted (L1-L2 level). General anesthesia was induced with propofol and sufentanil, and maintained with sevoflurane in O2/N2O. After emergence from anesthesia, epidural analgesia was initiated according to two randomly assigned protocols: 1 mg of morphine with 75 microg of clonidine (Group M) or 12.5 mg of bupivacaine with 75 microg of clonidine (Group B), in 10 mL saline. Piritramide was administered during the first postoperative 24 hours using a patient-controlled analgesia device (PCA). The following parameters were recorded: piritramide consumption during the first 24 hours; pain at rest during the first postoperative hours (D0), during the first night (D1), and during the first mobilization; [visual analogue scale (VAS)]; and the occurrence of drowsiness, motor blockade, respiratory depression, nausea, vomiting, itching, micturition problems, and bladder catheterization during D0 and D1. Epidural administration of morphine-clonidine significantly improved postoperative pain relief and reduced piritramide consumption as compared to epidural bupivacaine-clonidine. Side effects did not differ between groups except for a higher incidence of micturition problems in Group M during D1. The occurrence of bladder catheterization was not significantly higher in that group. We conclude that a low dose of epidural morphine combined with clonidine offers a better postoperative analgesia than does bupivacaine-clonidine. The excellent analgesic conditions were obtained at the expense of a higher incidence of difficulties in initiating micturition. [less ▲]

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See detailAnti-CD3/anti-epidermal growth factor receptor-bispecific antibody retargeting of lymphocytes against human neoplastic keratinocytes in an autologous organotypic culture model
Renard, I.; Mezzanzanica, Delia; Canevari, Silvana et al

in American Journal of Pathology (2002), 160(1), 113-122

Local cellular immune defects have been described in several tumors including human papillomavirus (HPV)-associated cervical cancer. This observation suggests the potential therapeutic benefit of immune ... [more ▼]

Local cellular immune defects have been described in several tumors including human papillomavirus (HPV)-associated cervical cancer. This observation suggests the potential therapeutic benefit of immune manipulations that restore cellular immunity. Here, we evaluated the ability of bispecific monoclonal antibodies (bimAbs) to redirect T cells against keratinocytes transformed in vitro by HPV in an autologous three-dimensional culture model (organotypic cultures). The epidermal growth factor receptor (EGFR) was chosen as target for an anti-CD3/anti-EGFR bimAb because it is overexpressed in many malignant epithelial lesions and only weakly expressed in the basal layers of normal squamous epithelium. Interestingly, in organotypic cultures, the pattern of expression of EGFR was similar to that observed in vivo. The ability of T cells retargeted by CD3/EGFR bimAb to lyse HPV-transformed cell lines was confirmed in monolayer cultures. In autologous organotypic cultures, an increase in apoptotic HPV(+) keratinocytes and a significant decrease in the thickness of HPV(+) organotypic cultures were observed when activated lymphocytes and bimAbs were added to the cultures, whereas organotypic cultures of normal keratinocytes were not significantly affected. These data were similar to those obtained in the allogeneic model. These results suggest the potential usefulness of CD3-EGFR bimAb-retargeted lymphocytes in immunotherapeutic protocols for malignant epithelial lesions. [less ▲]

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See detailFaut-il faire un echocardiogramme avant une angioplastie directe pour infarctus myocardique aigu?
Pierard, Luc ULg

in Annales de Cardiologie et d'Angeiologie (2002), 51(1), 51-2

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See detailLes kystes bronchogeniques: observation clinique et revue de la litterature
RADERMECKER, Marc ULg; Moscato, A.; Delbecque, Katty ULg et al

in Revue Médicale de Liège (2002), 57(1), 45-8

Pulmonary bronchogenic cysts are benign lesions that can be suspected from clinical background and imaging. We present the case of a huge subcarinal bronchogenic cyst and review the embryology ... [more ▼]

Pulmonary bronchogenic cysts are benign lesions that can be suspected from clinical background and imaging. We present the case of a huge subcarinal bronchogenic cyst and review the embryology, physiopathology, surgical indications and techniques of this congenital lesion. [less ▲]

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See detailLà-bas si j'y suis
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2002), 7

The article deals with the idea of place into the comics of Belgian artist Jean-Philippe Stassen.

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See detailWhole-body FDG-PET imaging in the management of patients with cancer
Hustinx, Roland ULg; Bénard, François; Alavi, Abass

in Seminars in Nuclear Medicine (2002), 32(1), 35-46

Fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is increasingly used for the management of patients with cancer. The technique is now well accepted by most physicians as an effective ... [more ▼]

Fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is increasingly used for the management of patients with cancer. The technique is now well accepted by most physicians as an effective complement to the existing imaging modalities. For many malignancies, PET achieves high sensitivity and specificity. The critical role of this powerful technique is realized increasingly in the day-to-day practice of oncology. This is particularly true for the management of patients with non-small-cell lung cancer (NSCLC). The contribution of PET for the selection of patients eligible for curative treatments in this setting is well established. Convincing data also exist to support the use of PET for evaluating patients with recurrent colorectal carcinoma, for staging and restaging lymphomas, and for diagnosing recurrent thyroid carcinoma in the presence of elevated thyroglobulin and negative I-131 scans. Other indications include staging of various recurrent malignancies, such as breast cancer, melanoma, and head and neck and gynecologic carcinomas. Existing data are limited for the determination of the impact of PET in certain malignancies, and further studies, which should include outcome information, will allow clarification of the role of this modality for such indications. Despite the small number of studies specifically designed to assess changes in management plans for some malignancies after performing PET the overall favorable results are encouraging enough at this time to include this modality as an essential element of the practice of modern oncology. Finally, the evolving role of PET imaging as a predictor of response after local or systemic treatment may add a major dimension to the application of this novel technique. Copyright (C) 2002 by WB. Saunders Company. [less ▲]

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See detailLes jeunes peuplements mélangés de hêtres et de bouleaux : étude bibliographique sur la forme des hêtres (cahier technique n°18)
Kiss, S.; Claessens, Hugues ULg

in Forêt Wallonne (2002), (55-56), 1-14

Avec cet article sur la mise en place de l’architecture du hêtre, de la plantule à l’arbre adulte, et sur les causes de sa malformation, nous entamons un cycle de deux cahiers techniques dédiés à la ... [more ▼]

Avec cet article sur la mise en place de l’architecture du hêtre, de la plantule à l’arbre adulte, et sur les causes de sa malformation, nous entamons un cycle de deux cahiers techniques dédiés à la sylviculture du hêtre en mélange avec le bouleau. Les premières parties abordent la définition d’une architecture d’arbre idéal et le rôle de la concurrence sur la forme des hêtres. Ces notions permettront, dans les parties ultérieures, de mieux désigner les individus destinés à devenir des arbres « objectif » et à comprendre le rôle des essences compagnes dans les plantations mélangées. Le bouleau servira d’essence de bourrage pour l’élaboration d’une sylviculture d’arbres adaptée aux mélanges. [less ▲]

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See detailChroniques douce-amères
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (2002), 7

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See detailConservation of the lesser horseshoe bat (Rhinolophus hipposideros Bechstein, 1800) (Mammalia : Chiroptera) in Belgium. A case study of feeding habitat requirements
Motte, G.; Libois, Roland ULg

in Belgian Journal of Zoology (2002), 132(1), 49-54

The aim of this study was to determine the habitat use of the last important Belgian colony of Rhinolophus hipposideros, Bechstein, 1800, one of the most endangered bat species in Europe. During 71 ... [more ▼]

The aim of this study was to determine the habitat use of the last important Belgian colony of Rhinolophus hipposideros, Bechstein, 1800, one of the most endangered bat species in Europe. During 71 evenings from April to August 1998, ultrasound detection was performed and, in late August, a female horseshoe bat was caught and fitted with a radio transmitter. The results showed that hedgerows and woodlands with bushes and coppice are key foraging habitats. They also highlight the importance of the presence of a network of wooded elements connecting the maternity roost with the foraging areas. To assure long-term protection of this colony, strong habitat conservation measures should be taken in a radius of up to 1-2 km around the roost. [less ▲]

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See detailAn improved clean-up strategy for simultaneous analysis of polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and polychlorinated biphenyls (PCB) in fatty food samples
Pirard, Catherine ULg; Focant, Jean-François ULg; De Pauw, Edwin ULg

in Analytical and Bioanalytical Chemistry (2002), 372(2), 373-381

The study and extension of a simple automated clean-up method for polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) to a broad range of polychlorinated biphenyls (PCB) is ... [more ▼]

The study and extension of a simple automated clean-up method for polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) to a broad range of polychlorinated biphenyls (PCB) is described. The isolation of seven PCDD, ten PCDF, and three coplanar PCB (cPCB) is extended to eight monoortho substituted PCB and seven so-called "marker PCB" (Aroclor 1260) for fatty food samples. This enables quantification of 35 compounds - including all congeners with a WHO toxic equivalent factor (TEF)--in a single extraction and single purification step. The chromatographic behaviour of mono-ortho PCB and marker PCB on a variety of adsorbents, including basic alumina, has been studied. Partitioning of analytes through multi-column sequences is described and correlated with their structural and electronic properties, by use of molecular modelling calculations. The fractionation process available with the Power-Prep automated clean-up system enables rapid independent analysis of the different groups of compounds. Gas chromatography with high resolution mass spectrometry (GC-HRMS) is used for the PCDD/F and cPCB fraction and quadrupole ion-storage tandem in time mass spectrometry (GC-QISTMS) for analysis of the remaining PCB. A comparison study was performed on quality-control samples and real fatty food samples to evaluate the robustness of the new strategy compared with a reference method. On the basis of this simultaneous clean-up, a rapid simplified strategy for PCDD/F and selected PCB analysis determination is proposed for fatty food samples. [less ▲]

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See detailMorsure de chien chez un patient splénectomisé
Delanaye, Pierre ULg; Dubois, Colette ULg; Mendes, Pedro et al

in Revue Médicale de Liège (2002), 57(1), 40-4

We present a case of Capnocytophaga canimorsus fulminant infection linked to a dog bite in a splenectomized patient. Capnocytophaga canimorsus is a gram-negative rod that typically causes septicaemia with ... [more ▼]

We present a case of Capnocytophaga canimorsus fulminant infection linked to a dog bite in a splenectomized patient. Capnocytophaga canimorsus is a gram-negative rod that typically causes septicaemia with disseminated intravascular coagulation in both immunocompromised and immunocompetent hosts. It is associated with high mortality. We also reviewed the literature and provide some recommendations on the management of bite wound as well as on both prevention and treatment of infection in asplenic state. [less ▲]

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See detailA scheduler for relative delay service differentiation
Jennes, Geoffroy ULg; Leduc, Guy ULg; Tufail, Mudassir

in Annales des Télécommunications = Annals of Telecommunications (2002), 57(1-2, JAN-FEB), 83-104

We propose a new delay-based scheduler called as RD-VC (Relative Delay VirtualClock). Since it performs a delay-based service differentiation among flow aggregates, the quality at microflow level is the ... [more ▼]

We propose a new delay-based scheduler called as RD-VC (Relative Delay VirtualClock). Since it performs a delay-based service differentiation among flow aggregates, the quality at microflow level is the same as that at aggregate level. This is not easily achievable when the service differentiation is bandwidth-based or loss-based. Unlike the EDF (Earliest Deadline First) scheduler [1], our proposed scheduler self-regulates and adapts the delays according to load changes. This characteristic permits its to implement it in an AF-like PHB providing the relative quantification service in a DiffServ network. Finally, we compare our proposed RD-VC scheduler with two important existing propositions: WTP (Waiting Time Priority) [2, 3] and EX-VC (Extended VirtualClock) [4]. Both these propositions are delay-based and have self-regulation property All three schedulers (RD-VC, WTP and EX-VC) maintain the required service differentiation among aggregates and have comparable long term average performance like mean throughput per aggregate and packet loss ratio etc. However, RD-VC and WTP take an edge over EX-VC at short-term performance like jitter. Both RD-VC and WTP have good long term and short-term performance. Our proposed RD-VC, compared to existing WTP, has two additional characteristics, i.e. unlike WTP which is limited to architectures with one queue per QoS class, it has no limitation on implementation scope (with or without separate queues per class) and it has lower complexity. This renders RD-VC an interesting proposition. [less ▲]

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See detailLe cas clinique du mois. Membrane sous-valvulaire aortique
Radermecker, M.A.; Dresse, Denise ULg; Grenade, T. et al

in Revue Médicale de Liège (2002), 57(1), 7-9

A case of fixed subvalvular aortic stenosis is reported. This clinical observation is the occasion to review the pathophysiology of this lesion and the last developments in the surgical treatment.

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See detailTraite des êtres humains : un coup de frein à l'application de l'article 77bis de la loi du 15 décembre 1980 ?
Monville, Pierre ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

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See detailRate coefficient determination in charge transfer reactions
Vaeck, Nathalie; Baloïtcha, Ezinvy; Desouter, Michèle ULg et al

in International Journal of Molecular Sciences (2002), 3

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See detailPhase And Amplitude Of Ecosystem Carbon Release And Uptake Potentials As Derived From Fluxnet Measurements
Falge, Eva; Tenhunen, John; Baldocchi, Dennis et al

in Agricultural and Forest Meteorology (2002), 113(1-4),

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See detailLe mélange épicéa-douglas, une association intéressante pour le sylviculteur ? 2e partie
Colson, Vincent ULg; Claessens, Hugues ULg; Pauwels, D. et al

in Silva Belgica (2002), 109(4), 25-31

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See detailMorphology, displacement and slip rates along the North Antolian Fault (Turkey)
Hubert, Aurelia ULg; Armijo, R.; Meyer, B. et al

in Journal of Geophysical Research (2002), 107(10.1029/2001JB000393),

Geological and geomorphological offsets at different scales are used to constrain the localization of deformation, total displacement, and slip rates over various timescales along the central and eastern ... [more ▼]

Geological and geomorphological offsets at different scales are used to constrain the localization of deformation, total displacement, and slip rates over various timescales along the central and eastern North Anatolian Fault (NAF) in Turkey. The NAF total displacement is reevaluated using large rivers valleys (80 ± 15 km) and structural markers (Pontide Suture, 85 ± 25 km; Tosya-Vezirko ̈pru ̈ basins, 80 ± 10 km). These suggest a Neogene slip rate of 6.5 mm/yr over 13 Myr. The river network morphology shows offsets at a range of scales (20 m to 14 km) across the main fault trace and is also used to estimate the degree to which deformation is localized. At a smaller scale the morphology associated with small rivers is offset by 200 m along the NAF. The age of these features can be correlated with the Holocene deglaciation and a slip rate of 18 ± 3.5 mm/yr is determined. This is consistent with a rate of 18 ± 5 mm/yr deduced independently from the 14C dating of stream terrace offsets. Over the short term, GPS data gives a similar rate of 22 ± 3 mm/yr. All our results tend to show that most of the deformation between the Anatolian and Eurasian lithospheric plates has been accommodated along, or very close to, the active trace of the NAF. The difference between the Neogene and the Holocene slip rate may be due to the recent establishment of the current plate geometry after the creation of the NAF. INDEX TERMS: 8107 Tectonophysics: Continental neotectonics; 8158 Tectonophysics: Plate motions—present and recent (3040); 7230 Seismology: Seismicity and seismotectonics; KEYWORDS: North Anatolian Fault, slip rate, total offset, strain localization [less ▲]

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See detailSubcellular Localization Of The Bovine Leukemia Virus R3 And G4 Accessory Proteins
Lefebvre, Laurent; Ciminale, Vincenzo; Vanderplasschen, Alain ULg et al

in Journal of Virology (2002), 76(15), 7843-7854

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for ... [more ▼]

Bovine leukemia virus (BLV) is a complex retrovirus that belongs to the Deltaretrovirus genus, which also includes Human T-cell leukemia virus type 1 (HTLV-1). Both viruses contain an X region coding for at least four proteins: Tax and Rex, which are involved in transcriptional and posttranscriptional regulation, respectively, and the accessory proteins R3 and G4 (for BLV) and p12(I), p13(II), and p30(II) (for HTLV-1). The present study was aimed at characterizing the subcellular localization of BLV R3 and G4. The results of immunofluorescence experiments on transfected HeLa Tat cells demonstrated that R3 is located in the nucleus and in cellular membranes, as previously reported for HTLV-1 p12(1). In contrast, G4, like p13(II), is localized both in the nucleus and in mitochondria. In addition, we have shown that G4 harbors a mitochondrial targeting signal consisting of a hydrophobic region and an amphipathic alpha-helix. Thus, despite a lack of significant primary sequence homology, R3 and p12(1) and G4 and p13(II) exhibit similar targeting properties, suggesting possible overlap in their functional properties. [less ▲]

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See detailApplication de Pichia anomala souche K, Beta 1,3-glucanes et chlorure de Calcium pour le contrôle des maladies de conservation des pommes en conditions proches de la pratique
Jijakli, Haissam ULg; Dickburt, C.; De Clerck, D. et al

in Colloque transnational sur les luttes biologiques, intégrée et raisonnée (2002)

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See detailExamination of Escherichia coli from poultry for selected adhesin genes important in disease caused by mammalian pathogenic E. coli
Stordeur, Philippe; Marlier, Didier ULg; Blanco, J. et al

in Veterinary Microbiology (2002), 84(3), 231-241

A collection of 1601 extraintestinal and intestinal Escherichia coli isolated from chickens, turkeys and ducks. in Belgium, France and Spain, was hybridised with gene probes specific for fimbrial and ... [more ▼]

A collection of 1601 extraintestinal and intestinal Escherichia coli isolated from chickens, turkeys and ducks. in Belgium, France and Spain, was hybridised with gene probes specific for fimbrial and afimbrial adhesins (F17, F18, S (Sfa/F1C), Bfp, Afa, Cs31A, Intimin (Eae), Aida-1) of intestinal, urinary and invasive E. coli of mammals and with a probe specific for the P (Pap/Prs) fimbrial adhesin of urinary and invasive E. coli of mammals and birds. Three hundred and eighty-three strains (23.9%) were P-positive, 76 strains (4.8%) were Afa-positive, 75 strains (4.7%) were F17-positive, 67 strains (4.2%) were S-positive, 23 (1.4%) were Intimin-positive. and all were F18-, Cs31A-, Aidal- and Bfp-negative. The 75 F17-positive strains harboured different major subunit A-encoding gene variants, but the f17Ac variant was the most frequent (52 strains, 69,3%) and seven strains (9.3%) were not typeable. The f17G gene variant coding for the GII adhesin was the most frequent (56 strains, 75.0%), whereas the f17GI gene variant was present in four strains (5%) and 15 strains (20.0%) were not typeable. All Afa-positive strains harboured the afa-8 variant. The 23 Intimin-positive E. coli tested positive for the beta -variant (16 strains; 69.6%) or for the gamma -variant (seven strains;, 30.4%) of the eae gene. Chicken and turkey E. coli were more frequently probe-positive (43.6 and 43.1 %, respectively) than duck E. coli 31.5%) and extraintestinal E. coli were also more frequently probe-positive (48.4%) than intestinal strains (18.5%). Different combinations of probe positive hybridisation results were observed in 72 of the 540 probe-positive E. coli (13.3%). The most frequent combinations were between AfaE-8 and F17 probes (47 strains; 8.7%) and between P and S probes (13 strains. 2.4%). Although f17- and afa-8-related DNA sequences can be plasmid-located in mammalian E. coli. they were not in avian E. coli. Besides the P fimbrial adhesin, F17 and S fimbrial and Afa-VIII and Intimin afimbrial adhesins may thus represent colonisation factors of avian pathogenic E. coli. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPresence in bovine enteropathogenic (EPEC) and enterohaemorrhagic (EHEC) Escherichia coli of genes encoding for putative adhesins of human EHEC strains
Szalo, Ioan Mihai ULg; Goffaux, Frédéric; Pirson, Vinciane et al

in Research in Microbiology (2002), 153(10), 653-658

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) infections are characterised by the formation of attaching and effacing lesions on intestinal epithelial cells. The first step of ... [more ▼]

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) infections are characterised by the formation of attaching and effacing lesions on intestinal epithelial cells. The first step of EPEC and EHEC pathogenesis involves the initial adherence of the bacterium to the intestinal epithelium. A collection of bovine EPEC and EHEC strains belonging to different serogroups was tested by colony blot hybridization with gene probes for putative adhesins (BFPA, LPFA, IHA, LIFA) of human EPEC and EHEC, and also for fimbrial and afimbrial adhesins (AFA8, F17, Cs31A) of bovine necrotoxigenic E. coli (NTEC). In the bovine EPEC and EHEC strains tested, sequences homologous to lifA, ihA, and lpfA genes were detected, sometimes in association with particular serogroups. Bovine O26 EPEC also possessed a sequence homologous to a gene of the clp operon, coding for the CS31A adhesin, associated with bovine NTEC. Overall results showed that different genes encoding for putative adhesins of human EHEC strains are present in bovine EPEC and EHEC strains, but not one of them is present in all strains. [less ▲]

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See detailEnzymatically prepared n-alkyl esters of glucuronic acid: The effect of hydrophobic chain length on surface properties
Blecker, Christophe ULg; Piccicuto, S.; Lognay, Georges ULg et al

in Journal of Colloid & Interface Science (2002), 247(2), 424-428

The effect of hydrophobic chain length on surface properties of enzymatically prepared n-alkyl esters of glucuronic acid are examined. Dynamic parameters from Hua and Rosen's mathematical model and ... [more ▼]

The effect of hydrophobic chain length on surface properties of enzymatically prepared n-alkyl esters of glucuronic acid are examined. Dynamic parameters from Hua and Rosen's mathematical model and equilibrium surface tension are presented for esters with octyl, decyl, dodecyl, and tetradecyl alkyl segments. Increasing the alkyl chain length has a significant influence on the surface activity. Decyl and dodecyl glucuronate exhibit an interesting adsorption speed associated with foaming capacity. Octyl glucuronate exhibits a micellar organization as its bulk concentration is over 10.68 mM. (C) 2002 Elsevier Science (USA). [less ▲]

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See detailThe antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
Hajitou, Amin; Grignet, Christine ULg; Devy, L. et al

in FASEB Journal (2002), 16

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by ... [more ▼]

Endostatin and angiostatin are known as tumor-derived angiogenesis inhibitors, but their mechanisms of action are not yet completely defined. We report here that endostatin and angiostatin, delivered by adenoviral vectors, reduced in vitro the neovessel formation in the mouse aortic ring assay by 85 and 40%, respectively. We also demonstrated in vivo that both endostatin and angiostatin inhibited local invasion and tumor vascularization of transplanted murine malignant keratinocytes, and reduced by 50 and 90% the development of highly vascularized murine mammary tumors. This inhibition of tumor growth was associated with a reduction of tumor vascularization. Expression analysis of vascular endothelial growth factor (VEGF) carried out in the mouse aortic ring model revealed a 3- to 10-fold down-regulation of VEGF mRNA expression in endostatin-treated rings. A similar down-regulation of VEGF expression at both mRNA and protein levels was also observed in the two in vivo cancer models after treatment with each angiogenesis inhibitor. This suggests that endostatin and angiostatin effects may be mediated, at least in part, by their ability to down-regulate VEGF expression within the tumor. This work provides evidence that endostatin and angiostatin act on tumor cells themselves. [less ▲]

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See detailStudy of the structural, electronic, and magnetic properties of the barium-rich iron(IV) oxides, Ba2FeO4 and Ba3FeO5
Delattre, J. L.; Stacy, A. M.; Young, V. G. et al

in Inorganic Chemistry (2002), 41(11), 2834-2838

Crystals of Ba2FeO4 and Ba3FeO5, grown from a "self-sealing" KOH-Ba(OH)(2) flux, have been characterized by single-crystal X-ray diffraction, Mossbauer spectroscopy, and magnetic measurements. Ba2FeO4 ... [more ▼]

Crystals of Ba2FeO4 and Ba3FeO5, grown from a "self-sealing" KOH-Ba(OH)(2) flux, have been characterized by single-crystal X-ray diffraction, Mossbauer spectroscopy, and magnetic measurements. Ba2FeO4 forms nonmerohedral twinned crystals with the monoclinic space group P2(1)/c, a = 6.034(2) Angstrom, b = 7.647(2) Angstrom, c = 10.162(3) Angstrom, beta = 92.931(6)degrees, and Z = 4. Ba3FeO5 crystallizes in the orthorhombic space group Pnma, with a = 10.301(1) Angstrom, b = 8.151(1) Angstrom, c = 7.611(1) Angstrom, and Z = 4. While both compounds feature discrete FeO44- tetrahedra, the anion found in Ba2FeO4 has shorter Fe-O bonds and is significantly distorted relative to the Ba3FeO5 anion, An iron valence of 4+ was confirmed by magnet susceptibility measurements and by the low-temperature isomer shifts of -0.152 and -0.142 mm/s relative to alpha-iron for Ba2FeO4 and Ba3FeO5, respectively. [less ▲]

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See detailMigration between States and Markets (Conference Report)
Martiniello, Marco ULg

in International Migration Review (2002), 36(2), 593-596

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See detailUne dorsalgie malheureusement tenace
Malaise, Michel ULg; Kaye, Olivier; Radermecker, Maurice ULg et al

in Revue Médicale de Liège (2002), 57(5), 270-273

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of ... [more ▼]

The etiological diagnosis of chronic thoracic pain is wide, from benign mechanical disorders to tumors. Reaching the exact diagnosis in often time consuming. Despite the availability of new techniques of imagery, a meticulous clinical history and physical examination remain mandatory. They will lead the exploration. Idiopathic intercostal neuralgia does not exist. [less ▲]

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See detailMechanical behaviour of Lixhe chalk partly saturated by oil and water: experiment and modelling
Collin, Frédéric ULg; Cui, Yu Jun; Schroeder, Christian ULg et al

in International Journal for Numerical and Analytical Methods in Geomechanics (2002), 26(9), 897-924

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical ... [more ▼]

Two or more different fluids generally saturate chalk in oil reservoir, and therefore its behaviour can be very complicated. In this paper, a constitutive law is proposed for modelling the mechanical behaviour of a chalk saturated by two non-miscible fluids, water and oil. The effects of the capillary pressure or suction are taken into account. They are considered as an independent variable, as in the Barcelona's basic model developed for unsaturated soils. On the other hand, internal friction and pore collapse are modelled as independent mechanisms. The determination of the parameters is based on triaxial and oedometer tests. Finally, in order to validate the model, predictions are compared with experimental results of water-flooding test. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailEnquête sur les "contes" de Voltaire
Tilkin, Françoise ULg

in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2002), 1

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See detailInfo-congres. Prevention du diabete de type 2 chez le sujet obese: premiers resultats avec l'orlistat dans l'etude XENDOS.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 617-21

The results of the XENDOS study were presented by Professor Lars Sjostrom (Gothenburg, Sweden), on August 26, 2002, at the 9th International Congress on Obesity in Sao Paulo, Brazil. XENDOS (XENical in ... [more ▼]

The results of the XENDOS study were presented by Professor Lars Sjostrom (Gothenburg, Sweden), on August 26, 2002, at the 9th International Congress on Obesity in Sao Paulo, Brazil. XENDOS (XENical in the prevention of Diabetes in Obese Subjects) is a multicentre, randomised, double-blind, placebo-controlled, parallel-group prospective study performed in Sweden over a period of 4 years. The aim of XENDOS was to investigate the use of a weight loss agent (orlistat, Xenical) compared with lifestyle changes for the prevention of type 2 diabetes in obese patients (body mass index > or = 30 kg/m2). Weight loss was greater in the orlistat group (-6.9 kg; n = 1.640) than in the placebo group (-4.1 kg; n = 1.637; p < 0.001). Such a difference in weight reduction was sufficient to significantly reduce the cumulative incidence of type 2 diabetes (6.2% versus 9.0%; p = 0.0032; relative risk reduction of 37.3%). The difference was especially remarkable in obese patients with impaired glucose tolerance (21% of the cohort), with a reduction of conversion to diabetes from 28.8% in the placebo group to 18.8% in the orlistat group (p < 0.005) and a number needed to treat to avoid one event of 11 only. Significant and sustained reductions in cardiovascular risk factors such as arterial blood pressure and lipid levels were also observed in the orlistat group as compared to the placebo group. XENDOS is the first study demonstrating that an antiobesity agent, like orlistat, is able to reduce the progression to diabetes in obese subjects as compared with lifestyle changes alone. [less ▲]

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See detailPsychologie et histoire : une réflexion à double sens
Richelle, Marc ULg

in Anuario de Psicologia (2002), 33(2), 231-247

This reflection on the relations between psychology and history addresses four distinct issues. The first is the history of psychology: the importance of reference to the past, even if only to put current ... [more ▼]

This reflection on the relations between psychology and history addresses four distinct issues. The first is the history of psychology: the importance of reference to the past, even if only to put current research and theory into perspective. Second, the essential historical dimension of human is presented as a crucial aspect in defining the very object of psychological science; the "historical psychology" approach, specifically its French variety as represented by Ignace Meyerson's legacy, is breifly discussed. Third, the contribution of psychology to the work of historians is considered. Finally, the joint involvement of both psychology and history in contemporary society is discussed with reference to the use (and abuse) of history in the construction of collective identity and to the claims for repair for offenses and damages made in the past, echoed by the declarations of guilt on the part of their perpetrators, on more exactly their descendants. These issues are discussed in the light of psychological approaches to memory and forgetting. [less ▲]

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See detailContinuité de la délinquance entre l’adolescence et l’âge adulte
Born, Michel ULg

in Criminologie (2002), 35(1), 53-67

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See detailEntre analyse historiciste et interdisciplinarité : Pet Sounds des Beach Boys
Pirenne, Christophe ULg

in Musurgia (2002), IX(2), 9-22

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See detailBelgian-style Human Resource Management: A Case of Mistaken Identity
Claus, Lisbeth; Vloeberghs, Daniel; Pichault, François ULg

in European Management Journal (2002), 20(4), 438-446

Discusses various forces that affect the future of human resource management (HRM) in Belgium. Development of HRM in the country; Specific forces that have shaped the development and character of HRM ... [more ▼]

Discusses various forces that affect the future of human resource management (HRM) in Belgium. Development of HRM in the country; Specific forces that have shaped the development and character of HRM; Details of the condition of HRM in the country. [less ▲]

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