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See detailIntérêt clinique de la tomographie à émission de positons dans la détection et le bilan d'extension des lymphomes non Hodgkiniens de malignité intermédiaire ou élevée
Najjar, Fadi; Jerusalem, Guy ULg; Paulus, Patrick et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (1999), 23

Accurate staging of non-Hodkin's lymphoma (NHL) is important for treatment management. We studied 53 patients (40 patients at initial diagnosis and 13 patients at disease recurrence) with ... [more ▼]

Accurate staging of non-Hodkin's lymphoma (NHL) is important for treatment management. We studied 53 patients (40 patients at initial diagnosis and 13 patients at disease recurrence) with histopathologically proven aggressive NHL to assess the value of whole-body FDG positron emission tomography (PET) as an imaging modality for staging and restaging NHL. All patients in this comparative analysis were submitted to clinical examination ; computed tomography (CT) and whole-body PET studies before starting the treatment. Results : whole-body FDG-PET seems to be more sensitive than clinical examination and CT imaging for detection of lymph node regions infiltrated by NHL : there were 98 abnormal peripheral lymph node regions senn by FDG-PET : 59 observed by clinical examination and 39 clinically undetected. The clinical examination showed 9 additional nodal lesions not seen by PET. Of 77 thoracic and abdominopelvic trated by CT. The CT studies showed 5 additional nodal lesions. Extranodal lymphomatous localisations in the liver (n=5), spleen (n=14), lungs (n=8), pleura (n=9), digestive tract (n=4), pelvis (n=2) and other sites (n=9) were identified by PET. Bone marrow infiltration demonstrated by PET was confirmed by biopsy in 6/10 patients, however known medullary invasion was not seen by PET imaging in 5 patients. Conclusion : whole-body FDG-PET without attenuation correction is an efficient, non-invasive method for staging and restaging aggressive NHL but marrow biopsy remains to be performed in addition to PET. [less ▲]

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See detailLyngbyapeptin A, a modified tetrapeptide from Lyngbya bouillonii (Cyanophyceae)
Didier Klein; Jean-Claude Braekman; Désiré Daloze et al

in Tetrahedron Letters (1999)

Lyngbyapeptin A 1, a novel tetrapeptide containing the rate 3-methoxy-2-butenoyl moiety was isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Its structure (without ... [more ▼]

Lyngbyapeptin A 1, a novel tetrapeptide containing the rate 3-methoxy-2-butenoyl moiety was isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Its structure (without stereochemistry) was established by mass spectral- and two-dimensional NMR studies. [less ▲]

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See detailLa diabete de type 2: approaches diagnostiques, objectifs glycemiques et strategies therapeutiques.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (1999), 54(8), 659-66

Type 2 diabetes is a prevalent disease, with high morbidity and mortality rates, which is usually managed by general practitioners. We will discuss the new diagnostic approaches, the glycaemic goals and ... [more ▼]

Type 2 diabetes is a prevalent disease, with high morbidity and mortality rates, which is usually managed by general practitioners. We will discuss the new diagnostic approaches, the glycaemic goals and the therapeutic strategies which may contribute to improve both adequate management and prognosis of diabetic patients with type 2 diabetes. As far as possible, the management should be both individualized and integrated, not only focused on blood glucose control but also on the correction of other vascular risk factors frequently associated with diabetes (mainly arterial hypertension and dyslipidaemias). Obviously, the reduction of the incidence and severity of microangiopathy and macroangiopathy diabetic complications would require a tight collaboration between general practitioners and specialized physicians. [less ▲]

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See detailComputer Simulation Of Surfactin Conformation At A Hydrophobic/Hydrophilic Interface
Gallet, X.; Deleu, Magali ULg; Razafindralambo, Hary ULg et al

in Langmuir (1999), 15(7), 2409-13

Using a molecular modeling method, different conformations of surfactin at a hydrophobic/hydrophilic interface are established. Two conformations of the peptide ring (S1 and S2) provided by NMR ... [more ▼]

Using a molecular modeling method, different conformations of surfactin at a hydrophobic/hydrophilic interface are established. Two conformations of the peptide ring (S1 and S2) provided by NMR experiments built with three different aliphatic chains in folded or extended configurations were studied. For the structures including the S2 peptide ring conformation, the theoretical interfacial molecular area corresponds to the experimental limiting area A0 value obtained with a Langmuir film balance. The peptide ring is positioned in the plane of the interface with the two acidic chains close to each other and protruding in the aqueous phase, and the β-hydroxy fatty acid chain, folded to interact mainly with the Leu2 side chain and also with the Val4 side chain. This design has the largest calculated molecular area and would correspond to the most stable amphipathic structure representing the surfactin experimental behavior in weak compression. [less ▲]

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See detailL'etude clinique du mois. Prevention des accidents vasculaires cerebraux chez les patients avec fibrillation auriculaire.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(6), 561-3

A recent analysis of the literature, published in the 19 May issue of the JAMA, once again demonstrates the efficacy of warfarin, and its superiority on aspirin, in preventing stroke in patients with ... [more ▼]

A recent analysis of the literature, published in the 19 May issue of the JAMA, once again demonstrates the efficacy of warfarin, and its superiority on aspirin, in preventing stroke in patients with atrial fibrillation, at least in subjects at highest risk. However, a feasibility study, published in the 15 May issue of the British Medical Journal, points to the difficulties of implementing guidelines from evidence-based medicine in general practice, essentially because of the reluctance of the physician and/or the patient when the constraints, risks and even advantages of antithrombotic treatment are taken into account. [less ▲]

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See detailHet antigif. Maar is het nog op tijd?
Meesters, Gert ULg

in Over Taal (1999), 38(1), 35-36

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See detailL'observance therapeutique.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(11), 854-8

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication compliance seems to be rather low as 30 to 60% of no or poor adherence to medical ... [more ▼]

Compliance is defined as the extent to which a patient's behaviour coincides with medical or health advice. Medication compliance seems to be rather low as 30 to 60% of no or poor adherence to medical recommendation have been reported. Numerous factors may influence medication compliance among which patient's characteristics, disease particularities, drug treatment modalities or physician's attitudes. The consequences of medication non-compliance may not only be dangerous for patient's health, but also dramatically increase the financial cost for public health services. Thus, all energies should be devoted to improve drug compliance, including treatment optimization and simplification, patient's information and education, use of practical means that facilitate adherence to medical recommendation, the patient being responsible for his/her treatment. [less ▲]

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See detailAPH-1, a POU homeobox gene expressed in the salt gland of the crustacean Artemia franciscana
Chavez, Marcela; Landry, Claire; Loret, Suzanne et al

in Mechanisms of Development (1999), 87(1-2), 207-12

We characterized the first POU-homeoprotein in a crustacean (designated APH-1 for Artemia POU-Homeoprotein, EMBL Y15070). The amino acid sequence of the APH-1 POU-domain is identical, except for two ... [more ▼]

We characterized the first POU-homeoprotein in a crustacean (designated APH-1 for Artemia POU-Homeoprotein, EMBL Y15070). The amino acid sequence of the APH-1 POU-domain is identical, except for two residues, to that of the two class III POU proteins Cf1-a (Drosophila) and POU-M1 (Bombyx mori). Southern blot analysis suggests that crustaceans have only one class III POU gene. RT-PCR and whole-mount in situ hybridization show that APH-1 mRNA is present in larvae specifically in the salt gland, an organ which is involved in osmoregulation, and disappears in the adult. [less ▲]

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See detailLe diabete gestationnel: definition, depistage et traitement.
Geronooz, I.; Scheen, André ULg; Foidart, Jacqueline ULg

in Revue Médicale de Liège (1999), 54(5), 429-33

Defined as glucose intolerance with onset or first recognition during pregnancy, gestational diabetes mellitus represents in fact an heterogeneous clinical entity which may concern 1 to 4% of all pregnant ... [more ▼]

Defined as glucose intolerance with onset or first recognition during pregnancy, gestational diabetes mellitus represents in fact an heterogeneous clinical entity which may concern 1 to 4% of all pregnant women in our country. Its adverse effects on the mother and her child, the need for a universal screening and the mode of screening are still controversial. Screening may be made either by a first test with a 50 g oral glucose load (the so-called O'Sullivan test), confirmed if positive by a 100 g oral glucose tolerance test (OGTT), or at first glance by a 75 g OGTT performed between the 24th and 28th weeks of gestation. The treatment of gestational diabetes is based on diet. In case of diet failure to obtain good glucose control, insulin therapy should be proposed. [less ▲]

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See detailSingle motor unit H reflexes recorded in thenar muscles at rest.
Wang, François-Charles ULg; Delwaide, Paul ULg

in Muscle & nerve (1999), 22(2), 291-2

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See detailL'etude clinique du mois. L'etude LIPID: "long-term intervention withpravastatin in ischaemic disease".
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 2-3

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6 ... [more ▼]

The LIPID study is a placebo-controlled, double-bind, randomized trial, performed in 9014 patients with coronary heart disease and total cholesterol levels of 155 to 271 mg/dl. After a mean follow-up of 6.1 years, patients receiving pravastatin (40 mg/day) had significantly (p < 0.001) lower death rate from coronary heart disease (24%), lower overall mortality (22%) and lower incidence of all cardiovascular outcomes (20 to 29% depending on the event). Interestingly enough, the reduction in death from coronary heart disease or nonfatal myocardial infarction was observed whatever the initial cholesterol concentration, and already significant if total cholesterol was < 213 mg/dl and LDL cholesterol was < 135 mg/dl. Thus, in secondary prevention, the favourable effect of the statin on the coronary heart disease outcomes is observed even in case of initial cholesterol levels yet considered as "normal". [less ▲]

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See detailFunctional and cooperative interactions between the homeodomain PDX1, Pbx, and Prep1 factors on the somatostatin promoter
Goudet, Ghylène; Delhalle, Sylvie; Biemar, Frédéric et al

in Journal of Biological Chemistry (1999), 274(7), 4067-73

Expression of the somatostatin gene in endocrine pancreatic cells is controlled by several regulatory cis-elements located in the promoter region. Among these, the adjacent UE-A and TSEI elements, located ... [more ▼]

Expression of the somatostatin gene in endocrine pancreatic cells is controlled by several regulatory cis-elements located in the promoter region. Among these, the adjacent UE-A and TSEI elements, located from -113 to -85 relative to the transcription initiation site, function in combination and act as a pancreas-specific mini-enhancer. The TSEI element is recognized by the pancreatic homeodomain factor PDX1. In the present study, we show that the UE-A element binds a heterodimeric complex composed of a Pbx factor and the Prep1 protein, both belonging to the atypical three-amino acid loop extension homeodomain family. Recombinant Pbx1 and Prep1 proteins bind cooperatively to the UE-A site, whereas neither protein can bind this site alone. Transient transfection experiments reveal that both Pbx1 and Prep1 are required to generate a strong transcriptional activation from the UE-A element when this element is inserted close to the TATA box. In contrast, in the context of the intact somatostatin promoter or mini-enhancer, Pbx1 and Prep1 alone have no effect, but they produce a drastic activation when the pancreatic homeodomain factor PDX1 is also coexpressed. Thus, the activity of the somatostatin mini-enhancer is mediated by a cooperative interaction between the Pbx-Prep1 heterodimeric complex and the pancreatic factor PDX1. [less ▲]

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See detailL'etude clinique du mois. Etudes cliniques a long terme (1-2 ans) avec l'orlistat, nouveau medicament pour le traitement de l'obesite.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(8), 707-9

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent ... [more ▼]

Orlistat (Xenical), whose original mechanism of action consists of the selective inhibition of gastrointestinal lipases, has been recently commercialized for the treatment of obesity. Despite its recent launch and when compared to common anorectic agents, it has been much better evaluated in long-term trials carried out according to the rules of Good Clinical Practice. We will summarize the four recently published randomized, placebo-controlled, double-blind clinical trials lasting up to 1 to 2 years and evaluating the effects of orlistat 3 x 120 mg/day in obese patients (BMI > or = 28 kg/m2). [less ▲]

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See detailPreference of Cd(II) and Zn(II) for the two metal sites in Bacillus cereus beta-lactamase II: A perturbed angular correlation of gamma-rays spectroscopic study.
Paul-Soto, R.; Zeppezauer, M.; Adolph, H. W. et al

in Biochemistry (1999), 38(50), 16500-6

Cd-substituted forms of the Bacillus cereus metallo-beta-lactamases (BCII) were studied by perturbed angular correlation of gamma-rays (PAC) spectroscopy. At very low [Cd]:[apo-beta-lactamase] ratios, two ... [more ▼]

Cd-substituted forms of the Bacillus cereus metallo-beta-lactamases (BCII) were studied by perturbed angular correlation of gamma-rays (PAC) spectroscopy. At very low [Cd]:[apo-beta-lactamase] ratios, two nuclear quadrupole interactions (NQI) were detected. For [Cd]:[apo-beta-lactamase] ratios between 0.8 and 3.0, two new NQIs appear, and the spectra show that up to 2 cadmium ions can be bound per molecule of apoenzyme. These results show the existence of two interacting Cd-binding sites in BCII. The relative populations of the two NQIs found at low [Cd]:[apo-beta-lactamase] ratios yielded a 1:3 ratio for the microscopic dissociation constants of the two different metal sites (when only one cadmium ion is bound). X-ray diffraction data at pH 7.5 demonstrate that also for Zn(II) two binding sites exist, which may be bridged by a solvent molecule. The measured NQIs could be assigned to the site with three histidines as metal ligands (three-His site) and to the site with histidine, cysteine, and aspartic acid as metal ligands (Cys site), respectively, by PAC measurements on the Cys168Ala mutant enzyme. This assignment shows that cadmium ions preferentially bind to the Cys site. This is in contrast to the preference of Zn(II) in the hybrid Zn(II)Cd(II) enzyme, where an analysis of the corresponding PAC spectrum showed that Cd(II) occupied the Cys site, whereby Zn(II) occupied the site with three histidines. The difference between Zn(II) and Cd(II) in affinity for the two sites is combined with the kinetics of hydrolysis of nitrocefin for different metal ion substitutions (Zn(2)E, ZnE, Cd(2)E, CdE, and ZnCdE) to study the function of the two metal ion binding sites. [less ▲]

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See detailLe risque cardio-vasculaire lie a l'hypercholesterolemie: d'un continuum a la notion de normalite, de seuil d'intervention et d'objectif therapeutique.
Scheen, André ULg

in Revue Médicale de Liège (1999), 54(1), 17-21

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more ... [more ▼]

There appears to be a continuum between the cardiovascular risk and the level of blood cholesterol, which hinders the definition of normal values, intervention threshold and therapeutic goals. The more and more convincing evidences provided by the "Evidence-Based Medicine" should be confronted to the pharmaco-economical constraints in order to first focus the essential of the efforts and resources on the target population with the highest risk. Unfortunately, the therapeutic strategy concerns a rather high percentage of the population of industrialized countries. [less ▲]

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See detail“La Destruction fut ma Béatrice”. Mallarmé ou l’implosion poétique
Durand, Pascal ULg

in Revue d'Histoire Littéraire de la France (1999), 3

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See detailLa sécheresse buccale en gériatrie
Hockers, Thierry ULg; Lamy, Marc ULg

in Revue Belge de Médecine Dentaire = Belgisch Tijdschrift voor Tandheelkunde (1999), 54(1), 41-50

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly ... [more ▼]

Dry mouth is usual in geriatrics. It doesn't seem a age related change of salivary gland tissues, but as often as not, it results from the use of some drugs. Seventy percents of institutionalised elderly population consummate these medications with buccal significance. This publication tries to summarize the means of diagnosis and the possibilities to treat this pathology. [less ▲]

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See detailMadangolide and Laingolide A, Two Novel Macrolides from Lyngbya bouillonii (Cyanobacteria)
Klein, D.; Daloze, D.; Hoffmann, L. et al

in Journal of Natural Products (1999)

Two new macrolide derivatives, madangolide (2) and laingolide A (3), have been isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Their structures (without stereochemistry ... [more ▼]

Two new macrolide derivatives, madangolide (2) and laingolide A (3), have been isolated from the cyanobacterium Lyngbya bouillonii, collected in Papua New Guinea. Their structures (without stereochemistry) have been established by detailed high-field 1D and 2D NMR studies and, in the case of 3, by comparison with the spectroscopic data of laingolide (1), previously isolated from the same organism. [less ▲]

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See detailGoverning biodiversity
Mougenot, Catherine ULg; Mormont, Marc ULg

in International Journal of Environment and Pollution (1999), 12(4), 78-99

he hypothesis of this paper is that the value conferred on nature designates both the ''objects of nature'' that are the subject of consideration, and the human beings for whom they are intended or who ... [more ▼]

he hypothesis of this paper is that the value conferred on nature designates both the ''objects of nature'' that are the subject of consideration, and the human beings for whom they are intended or who are responsible for them. These designation processes are dynamic and linked, but also interdependent. In order to examine these processes more closely, we make use of the concept of network, which integrates the action of different players in their specific world, as well as ''objects'' that can be as different as scientific nomenclatures, available sites, management plans, funds, etc. In other words, protection practices link up different universes, scientific models and practices, institutional practices, nature conservation practices and, finally, the evolution of species and natural sites that are not passive entities. The fact that we speak of ''socio-natural'' networks indicates that nature conservation is ''based'' on chains of equivalences that integrate these different players and universes. The processes are dynamic ones. The paper therefore examines how they can be stabilised or expanded, and also how they can be transformed in a much more radical manner. The study is applied to the Walloon Region (in Belgium). The paper first looks at what could be considered as the ''classical nature conservation network'', and then examines how it is called to evolve. The fact is that contemporary situations lead us to take account of different types of networks for conserving and maintaining nature. These are compared, and the paper examines how each of them attempts to take account of the increasingly complex and also increasingly open concept of biodiversity. This perspective of networking also leads us to conclude that none of these networks (scientific, economic, legislative, institutional, etc.) that go to make up nature conservation is capable on its own of giving value to nature. This is acquired - or not - only by building a hybrid chain that cuts across or integrates these different worlds. [less ▲]

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See detailOral status and nutrition in the institutionalized elderly.
Lamy, Marc ULg; Mojon, P.; Kalykakis, G. et al

in Journal of Dentistry (1999), 27(6), 443-8

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more ... [more ▼]

OBJECTIVES: To evaluate, in an elderly population, whether poor oral status might be a contributing factor to the development of undernutrition and might be associated with less eating pleasure, more subjective eating difficulty and increased mashed food consumption. METHODS: An oral examination and an evaluation of masticatory capacity were performed on 120 institutionalized elderly subjects. The nutritional assessment included serum albumin concentration, the Mini Nutritional Assessment and a questionnaire on eating habits. RESULTS: Edentulous subjects without dentures or with only one complete denture had significantly lower MNA scores than edentulous subjects with two complete dentures (p < 0.05). Edentulous subjects with two complete dentures more frequently reported taking pleasure from eating (p = 0.05), and had less frequent difficulties with hard foods (p = 0.01) than edentulous subjects without dentures or with only one complete denture. Mashed food consumption (p < 0.01) was also reported more frequently in edentulous subjects without dentures or with only one complete denture. Subjects with two complete dentures had similar or better MNA scores as dentate subjects with relatively few remaining teeth (10.4 +/- 7.8 teeth). About half of the subjects (53%) could not perform the masticatory test. These subjects had lower MNA scores (p = 0.001) and a larger proportion ate mashed food (p < 0.001) compared to those who were able to perform the test. CONCLUSIONS: Poor oral status (edentulous without dentures or with only one complete denture) increased difficulty in eating hard foods, increased mashed food consumption and decreased eating pleasure. It seemed also to put institutionalized subjects at higher risk of undernutrition. [less ▲]

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See detailMatrix-metalloproteinases in bronchopulmonary carcinomas.
Martinella-Catusse, C.; Nawrocki, B.; Gilles, Christine ULg et al

in Histology and Histopathology (1999), 14(3), 839-43

Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the extracellular matrix and therefore participate in tumoural invasion. MMPs ... [more ▼]

Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the extracellular matrix and therefore participate in tumoural invasion. MMPs, especially gelatinases A and B, MT1-MMP, the activator of gelatinase A, and stromelysin-3 were found overexpressed in many cancers including bronchopulmonary carcinomas. In vivo observations revealed that fibroblasts are the principal source of production of MMPs. Some of these enzymes such as MT1-MMP and stromelysin 3, displayed a focal stromal localisation near preinvasive and invasive tumour clusters. Furthermore, some tumour cell lines were shown to stimulate the expression of MT1-MMP by fibroblasts. All these in vivo and in vitro results suggest that certain tumour cells produce diffusible factors which could influence the MMP stromal expression. Among these factors, the TCSF (Tumor Collagenase Stimulatory Factor) which is known to upregulate some MMPs in vitro could be a good candidate for this stromal regulation, since it is produced by bronchial tumour cells in vivo. In this review, we address such a cooperation between tumour and stromal cells for the production of MMPs and emphasize their necessity for tumoural progression in bronchopulmonary carcinomas [less ▲]

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See detailLe neem et la lutte integree.
Schiffers, Bruno ULg

in Echos du COTA (1999), 84

L'agriculture est prise dans un cycle toujours plus contraignant d'intensification qui se fait au détriment de la qualité des produits et de l'environnement. Une solution partielle à ces dérives: utiliser ... [more ▼]

L'agriculture est prise dans un cycle toujours plus contraignant d'intensification qui se fait au détriment de la qualité des produits et de l'environnement. Une solution partielle à ces dérives: utiliser des plantes pour la protection des cultures. [less ▲]

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See detailAutour du chat de Cheshire et de son sourire: Approche phylogénétique du rire et du sourire humains
Servais, Véronique ULg

in Homme (L') : Revue Française d'Anthropologie (1999), volume 39 N° 150(avril-juin), 157-176

The paper offers an original synthesis of the hypothesis of primatologists about the origins of human smile and laughter.

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See detailL'image du mois. Purpura thrombocytopenique auto-immun.
Smitz, Simon ULg; Neven, I.; Sautois, Brieuc ULg et al

in Revue Médicale de Liège (1999), 54(8), 645

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See detail• Compte-rendu de l'ouvrage de Jean Gaudemet: Droit privé romain
Gerkens, Jean-François ULg

in Actualités du Droit (1999), (3), 558-559

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See detailAuditory evoked potentials and multiple personality measures in migraine and post-traumatic headaches.
Wang, W.; Wang, Y.-H.; Fu, X. M. et al

in Pain (1999), 79(2-3), 235-42

Migraine sufferers have abnormal cerebral information processing and personality disorders, post-traumatic headache sufferers also have some personality changes. We therefore, studied intensity dependence ... [more ▼]

Migraine sufferers have abnormal cerebral information processing and personality disorders, post-traumatic headache sufferers also have some personality changes. We therefore, studied intensity dependence of auditory evoked potentials, Plutchik-van Praag's depression inventory, Zuckerman's sensation seeking scales and Zuckerman-Kuhlman's personality questionnaire in patients suffering from migraine without aura (n = 26) and chronic post-traumatic headaches (n = 26) as well as in healthy volunteers (n = 30). The migraine group showed significantly increased neuroticism-anxiety than controls, increased intensity dependence of N1-P2, and decreased thrill and adventure score compared with the controls and post-traumatic headaches. The post-traumatic headache had significantly increased depression compared with the controls, and increased disinhibition compared with the controls and migraines. This study demonstrates that the two headache types have different neurophysiological and personality traits. The pronounced intensity dependence of N1-P2 suggests a cortical potentiation response, together with a decreased thrill and adventure seeking, favor a lower serotonergic innervation in migraine. While the elevated disinhibition and depression, as consequences, may be linked with the wide cortical neuronal/axonal degeneration in post-traumatic headache. [less ▲]

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See detailLoi de protection des malades mentaux. La mise en observation psychiatrqiue
Boxho, Philippe ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1999), 21

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See detailIdentification and characterization of mRNAs differentially expressed in thyroid cells stimulated by a mitogenic treatment
Pirson, I.; Behrens, J.; Savonet, V. et al

in Biochimie (1999), 81

he aim of our work is to identify new genes and proteins involved in the control of the proliferation of thyroid cells as putative protooncogenes and antioncogenes. Several strategies are discussed. A ... [more ▼]

he aim of our work is to identify new genes and proteins involved in the control of the proliferation of thyroid cells as putative protooncogenes and antioncogenes. Several strategies are discussed. A first study has allowed to identify three new genes. Further search will use the differential display and gene arrays methodology. The role of the identified proteins coded by the genes is studied in vitro by the search of partner proteins by the double hybrid method and in vivo by mice gene knockout technology [less ▲]

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See detailA new observed pre-copulatory behaviour of the lesser-spotted dogfish, scyliorhinus canicula, in captivity
Domi, Nadège; Poncin, Pascal ULg; Voss, Jacques

in Société française d'Ichtyologie (1999)

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See detailEffectiveness of an acute pain service inception in a general hospital
Bardiau, Françoise ULg; Braeckman, M.M.; SEIDEL, Laurence ULg et al

in Journal of Clinical Anesthesia (1999), 11(7), 583-589

STUDY OBJECTIVES: To assess the effects of an Acute Pain Service (APS) inception on postoperative pain management in a general teaching hospital using pain indicators as performance measures. DESIGN: Open ... [more ▼]

STUDY OBJECTIVES: To assess the effects of an Acute Pain Service (APS) inception on postoperative pain management in a general teaching hospital using pain indicators as performance measures. DESIGN: Open, prospective, nonrandomized, observational study. SETTING: Postanesthesia Care Unit, surgical wards of University Hospital Center of Charleroi. PATIENTS: 1304 patients in the pre-APS inception phase and 671 patients after its implemention who have undergone various types of surgery (orthopedics, gynecology, urology, neurosurgery, stomatology, ear, nose, and throat, ophthalmic, abdominal, vascular-thoracic, plastic, and maxillofacial). INTERVENTIONS: An APS, nurse-based, anesthesiologist-supervised model was devised, based on the concept that postoperative pain relief can be greatly improved by providing in-service training for surgical nursing staff and optimal use of systemic analgesics. MEASUREMENTS AND MAIN RESULTS: Postoperative pain was assessed using a visual analog scale (VAS) every 4 hours for 72 hours in the two phases. Analgesic consumption was registered at the same time. Time-related VAS scores were summarized using several pain indicators. There was an overall improvement in the pain scores after APS inception. The differences were most pronounced, around 50%, in patients undergoing vascular, maxillofacial, gynecologic, and urologic surgeries, and stomatology. Regular administration of paracetamol and nonsteroidal antiinflammatory drugs decreased morphine consumption in the second phase. CONCLUSION: This study validates the benefits of a formal APS, using continuous monitoring of rest pain intensity and analgesic consumption in the postoperative period. Results not only support previous research findings but also offer outcome-based tools to evaluate current practices as compared with desired outcomes. [less ▲]

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See detailAdvective excess Ba transport as shown from sediment and trap geochemical signatures
Fagel, Nathalie ULg; André, Luc; Dehairs, Frank

in Geochimica et Cosmochimica Acta (1999), 63(16), 2353-2367

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE ... [more ▼]

We report the results of a geochemical study of sediment and trap material. Major and trace elements (Zr, Ba, rare earth elements, and Th) were analyzed on bulk sedimentary material collected along the NE Atlantic margin. Our aim is to test the widespread use of Ba-barite as a proxy for paleoproductivity in a continental margin area. This environment is of great interest because atmospheric-oceanic exchanges are important. In sediments, the geochemical signatures remain close to an upper crust reference, with flat shale-normalized rare earth elements patterns and constant elementary ratios. The calculated biogenic fraction of Ba or excess Pa (20-45%) remains lower than the excess Ba record in trap material (80-99%). The evolution of the geochemical signature along the margin reflects variable dilution of a detrital Post Archean Australian Shale-like component by a biogenic carbonaceous seawater-derived component. The trap material displays a wide range of variation in its trace element content (e.g., Ba similar to 150-3000 ppm, Zr similar to 2-100 ppm), except for the abyssal site, which is characterized by constant signature. In the two other sites, all of the trace element contents increase with water depth and present pronounced seasonal changes at each sampled water depth. The amount of excess Ba also increases in the deepest traps, and its evolution throughout the year mimics the change of the other analyzed trace elements. In contrast, its relationships with particulate organic carbon are not obvious. In term of fluxes, two periods of enhanced excess Ba fluxes are observed: (1) excess Pa flux increases with the detrital-like elements like Th especially during winter, and (2) excess Pa flux is enhanced without any change for the other trace elements during spring. To explain the first case, a supply through lateral advection is proposed. Such transient input of significant excess Ba flux will have a great impact on the yearly averaged estimation of the export production. Indeed, only the second case reflects a bloom in the biological productivity of the water column and must be taken into account in a mean calculation of the export production. Finally, a normalization of the excess Ba by detrital-like element like Th will help to discriminate between a real increase of the excess Ba due to local productivity change (high excess Ba and high excess Ba/Th ratio greater than or equal to 10,000) and any input due to advection process (high excess Ba but low excess Ba/Th ratio < 2000). Copyright (C) 1999 Elsevier Science Ltd. [less ▲]

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See detailNC100100, a new echo contrast agent for the assessment of myocardial perfusion--safety and comparison with technetium-99m sestamibi single-photon emission computed tomography in a randomized multicenter study.
Binder, T.; Assayag, P.; Baer, F. et al

in Clinical cardiology (1999), 22(4), 273-82

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to ... [more ▼]

BACKGROUND AND HYPOTHESIS: Myocardial contrast echocardiography using second-generation agents has been proposed to study myocardial perfusion. A placebo-controlled, multicenter trial was conducted to evaluate the safety, optimal dose, and imaging mode for NC100100, a novel intravenous second-generation echo contrast agent, and to compare this technique with technetium-99m sestamibi (MIBI) single-photon emission computed tomography (SPECT). METHODS: In a placebo-controlled, multicenter trial, 203 patients with myocardial infarction > 5 days and < 1 year previously underwent rest SPECT and MCE. Fundamental and harmonic imaging modes combined with continuous and electrocardiogram-- (ECG) triggered intermittent imaging were used. Six dose groups (0.030, 0.100, and 0.300 microliter particles/kg body weight for fundamental imaging; and 0.006, 0.030, and 0.150 microliter particles/kg body weight for harmonic imaging) were tested. A saline group was also included. Safety was followed for 72 h after contrast injection. Myocardial perfusion by MCE was compared with myocardial rest perfusion imaging using MIBI as a tracer. RESULTS: NC100100 was well tolerated. No serious adverse events or deaths occurred. No clinically relevant changes in vital signs, laboratory parameters, and ECG recordings were noted. There was no significant difference between adverse events in the NC100100 (25.7%) and in the placebo group (17.9%, p = 0.3). Intermittent harmonic imaging using the intermediate dose was superior to all other modalities, allowing the assessment of perfusion in 76% of all segments. Eighty segments (96%) with normal perfusion by SPECT imaging also showed myocardial perfusion with MCE. However, a substantial percentage of segments (61-80%) with perfusion defects by SPECT imaging also showed opacification by MCE. This resulted in an overall agreement of 66-81% and a high specificity (80-96%), but in low sensitivity (20-39%) of MCE for the detection of perfusion defects. CONCLUSION: NC100100 is safe in patients with myocardial infarction. Intermittent harmonic imaging with a dose of 0.03 microliter particles/kg body weight can be proposed as the best imaging protocol. Myocardial contrast echocardiography with NC 100100 provides perfusion information in approximately 76% of segments and results in myocardial opacification in the vast majority of segments with normal perfusion as assessed by SPECT. Although the discrepancies between MCE and SPECT with regard to the definition of perfusion defects requires further investigation, MCE with NC 100100 is a promising technique for the noninvasive assessment of myocardial perfusion. [less ▲]

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See detailWestward propagation of the North Anatolian fault into the northern Aegean: Timing and kinematics
Armijo, R.; Meyer, B.; Hubert, Aurelia ULg et al

in Geology (1999), 27

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the ... [more ▼]

We present new evidence for the propagation processes of the North Anatolian fault. Fold- ing in the Dardanelles Straits region allows us to document the timing of the deformation pre- ceding, and the finite displacement after, the passage of the propagating tip of the fault. The accuracy of the observations is due to interplay between deformation and the sea-level changes in the Mediterranean (the well-known Messinian regression followed by the Pliocene transgres- sion). The long-term kinematics around the Sea of Marmara pull-apart (total displacement of about 85 km over the past 5 m.y.) is similar to the present-day kinematics deduced from space geodesy. At a larger scale, westward propagation of the North Anatolian fault over nearly 2000 km in the past 10 m.y. appears to be associated with strain recovery, suggesting that the continental lithosphere retains long-term elasticity. [less ▲]

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See detailIndices d'aptitude des procédés de production
Palm, Rodolphe ULg

in Notes de Statistique et d'Informatique (1999), (5), 26

This note describes the main process capability indices and presents some inferential porperties. A numerical example is analysed by Minitab and SAS softwares.

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See detailPlasma myeloperoxidase level and polymorphonuclear leukocyte activation in horses suffering from large intestinal obstruction requiring surgery: preliminary results.
Grulke, Sigrid ULg; Benbarek, H.; Caudron, I. et al

in Canadian Journal of Veterinary Research = Revue Canadienne de Recherche Vétérinaire (1999), 63(2), 142-7

Myeloperoxidase (MPO) is a specific enzyme of neutrophil azurophilic granules with a strong oxidative activity. Thanks to a radioimmunoassay of equine myeloperoxidase, the authors have observed a ... [more ▼]

Myeloperoxidase (MPO) is a specific enzyme of neutrophil azurophilic granules with a strong oxidative activity. Thanks to a radioimmunoassay of equine myeloperoxidase, the authors have observed a significantly higher plasma level of MPO in horses operated for strangulation obstruction of the large intestine (n = 6) than in horses suffering from a non-strangulating displacement of the large intestine (n = 9). For the 2 groups, 3 phases were distinguished: reception (P1), intensive care (P2) and terminal phase (P3). The mean peak values of MPO for these phases were 121.6 ng/mL (P1), 168.6 ng/mL (P2), and 107.0 ng/mL (P3) for the non-strangulating group, and 242.6 ng/mL (P1); 426.0 ng/mL (P2), and 379.5 ng/mL (P3) for the strangulation group. The variations of the mean peak values of plasma MPO were significantly different between the 2 groups and between the different phases. A significant increase of the least square means of MPO was observed between P1 and P2. A significant decrease of the least square means of the number of circulating leukocytes was observed between P1 and P3. Polymorphonuclear neutrophil activation could play a major role in the pathogenesis of acute abdominal disease and endotoxic shock. [less ▲]

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See detailKarst dans les évaporites : marqueur efficace des événements récents. L’exemple du Mont Sédom (Israel)
Hallot, Eric ULg

in Bulletin de la Société Géographique de Liège (1999), 37

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See detailUne tâche pigmentée suspecte
Vanhooteghem, Olivier ULg; Richert, Bertrand ULg; de LA BRASSINNE, Michel ULg

in Revue de Médecine Générale [=RMG] (1999), 166

What is your diagnosis for this periungual coloured spot of the thumb ?

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See detailFamilial influences on cortical evoked potentials in migraine.
Sandor, P S; Afra, J; Proietti-Cecchini, A et al

in Neuroreport (1999), 10(6), 1235-8

Cortical information processing in migraine patients is impaired between attacks, showing deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of ... [more ▼]

Cortical information processing in migraine patients is impaired between attacks, showing deficient habituation of pattern-reversal visual evoked potentials (VEP), and strong intensity dependence of auditory cortical evoked potentials (IDAP). This could be a genetic trait as certain genetic patterns are known for evoked potentials in healthy subjects. We investigated VEP habituation and IDAP in 20 pairs of migraineurs made up of parents and their children. Using a Monte-Carlo statistical method, we selectively assessed vertical familial influences. VEP habituation and IDAP were abnormal in both parents and children. However, similarity was far more pronounced between related pairs than between unrelated pairs. Familial influences are highly significant in determinants of cortical information processing in migraineurs, hence supporting the important role of genetic factors. [less ▲]

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See detailFourfold basal plane anisotropy of the nonlocal magnetization of YNi2B2C
Civale, L.; Silhanek, Alejandro ULg; Thompson, J. R. et al

in Physical Review Letters (1999), 83(19), 3920-3923

Studies of single crystal YNi2B2C have revealed a fourfold anisotropy of the equilibrium maenetization in the square crystallographic basal plane. This pi/2 periodicity occurs deep in the superconductive ... [more ▼]

Studies of single crystal YNi2B2C have revealed a fourfold anisotropy of the equilibrium maenetization in the square crystallographic basal plane. This pi/2 periodicity occurs deep in the superconductive mixed state. In this crystal symmetry, an ordinary superconductive mass anisotropy (as in usual London theory) allows only a constant, isotropic response. In contrast, the experimental results are well described by generalized London theory incorporating nonlocal electrodynamics, as needed for this clean, intermediate-kappa superconductor. [less ▲]

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See detailComplementary finite element magnetodynamic formulations with enforced magnetic fluxes
Dular, Patrick ULg; Gyselinck, Johan; Henrotte, François et al

in Compel-the International Journal for Computation and Mathematics in Electrical and Electronic Engineering (1999), 18(4), 656-667

Two complementary 3D finite element formulations, with either the magnetic field or the magnetic vector potential as unknowns, are developed to deal with the modeling of eddy currents in electrical steel ... [more ▼]

Two complementary 3D finite element formulations, with either the magnetic field or the magnetic vector potential as unknowns, are developed to deal with the modeling of eddy currents in electrical steel laminations. The magnetic flux through the flux gates of the conducting region is imposed via the boundary terms of the weak formulations, in a natural way thanks to the use of edge finite elements. The two formulations are applied to a simple 1D eddy current problem with analytical solution. As a practical 3D application example, a T-joint region of an electrical steel lamination is considered. [less ▲]

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See detailAberglauben, Krankheit und das Böse. Exorzismus und Teufelsglaube im 18. und 19. Jahrhundert
Van den Bossche, Benoît ULg; Freytag, Niels

in Rheinisch-westfälische Zeitschrift für Volkskunde (1999), XLIV

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See detailVaux-et-Borset "La Chapelle Blanche" : campagne de fouille 1997
Hauzeur, Anne; Delye, Emmanuel ULg; Caspar, Jean-Paul

in Bulletin du Cercle archéologique Hesbaye-Condroz (1999), XXIV

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See detailInvolvement of indole-3-acetic acid in the circadian growth of the first internode of Arabidopsis
Jouve, Laurent; Gaspar, Thomas ULg; Kevers, Claire ULg et al

in Planta (1999), 209(1), 136-142

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity ... [more ▼]

The extension rate of the first inflorescence node of Arabidopsis was measured during light/dark or continuous light exposure and was found to exhibit oscillations which showed a circadian rhythmicity. Decapitation induced a strong inhibition of stem extension. Subsequent application of IAA restored growth and the associated extension-rate oscillations. In addition, IAA treatments, after decapitation, re-established the circadian rhythmicity visible in the intact plants during free run. This indicates that the upper zone of the inflorescence has a major influence on the extension rate of floral stems and implies a role for auxin. Application of N-(1-naphthyl)phthalamic acid, an IAA transport inhibitor, to an intact floral stem inhibited growth and the rhythmicity in the extension rate oscillations, indicating that IAA polar transport may play a role in the dynamics of stem elongation. Furthermore, IAA-aspartate application, after decapitation, did not restore growth and rhythmicity. Nevertheless, biochemical analysis of IAA and IAA-aspartate demonstrated circadian fluctuations of the endogenous levels of both compounds. These observations suggest that IAA metabolism is an essential factor in the regulation of the circadian growth rhythm of Arabidopsis floral stems. [less ▲]

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See detailPour une politique migratoire humaine et réaliste en Belgique, dans l'Europe de demain
Carlier, Jean-Yves ULg

in Annales de Droit de Louvain (1999), 59(3), 223-244

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See detailUse of multitrait evaluation procedures to improve reliability of early prediction of survival
Druet, Tom ULg; Solkner, J.; Gengler, Nicolas ULg

in Journal of Dairy Science (1999), 82(9), 20541-205416

Multitrait, across-country evaluation procedures were adapted to improve reliability of survival breeding values by combining direct information with yield and functional traits: milk persistency, somatic ... [more ▼]

Multitrait, across-country evaluation procedures were adapted to improve reliability of survival breeding values by combining direct information with yield and functional traits: milk persistency, somatic cell count, fertility (male and female), and calving ease (direct and maternal). A set of bulls was selected from the Austrian Simmental population based on mean original reliabilities of at least 0.50 for yield traits or of at least 0.20 for functional traits. Only breeding values above these limits were retained. The breeding values were deregressed, assuming that they were obtained by single-trait, sire-maternal grandsire models. An expectation maximization restricted maximum likelihood algorithm based on the multitrait, across-country evaluation equations was used to compute genetic correlations among all of these traits. These equations were solved, and the reliabilities of the solutions were also estimated. Mean rank correlation between direct and combined breeding values was 0.85 with values as low as 0.67 for the group of youngest bulls, Direct (original), indirect, and combined reliabilities were compared to appreciate the impact of our procedures on improvement of reliability of survival breeding values; This improvement, dependent on the level of reliability of direct and indirect information, could be up to 0.24 for animals with low direct reliability and high indirect reliability. For young bulls born in 1992 without reliable direct survival information but with already reliable information on yield and functional traits, mean reliability improvement was 0.13. For all bulls this value was still 0.06. [less ▲]

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See detailA nouveau des questions sur les droits du C.P.A.S. à l'égard des débiteurs alimentaires
Paris, Catherine ULg

in Revue Générale de Droit Civil Belge = Tijdschrift voor Belgisch Burgerlijk (1999)

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See detailOptimization of biosurfactant lipopeptide production from Bacillus subtilis S499 by Plackett-Burman design
Jacques, Philippe ULg; Hbid, C.; Destain, Jacqueline ULg et al

in Applied Biochemistry and Biotechnology (1999), 77-9

Bacillus subtilis S499 is well-known for its ability to produce two families of surfactant lipopeptides: Iturin A and Surfactin S1. Fermentation optimization for this strain was performed to amplify the ... [more ▼]

Bacillus subtilis S499 is well-known for its ability to produce two families of surfactant lipopeptides: Iturin A and Surfactin S1. Fermentation optimization for this strain was performed to amplify the surfactant production. Ten active variables were analyzed by two successive Plackett-Burman designs, consisting respectively of 12 and 16 experiments to give an optimized medium. The amount of biosurfactant lipopeptides in the supernatant of a culture carried out in this optimized medium was about five times higher than that obtained in nonoptimized rich medium. The analysis of the surfactant molecules produced in such optimized conditions has revealed the presence of a third family of lipopeptides: the fengycins. The time-dependent production of these three families of molecules in bioreactors showed that surfactin S1 is produced during the exponential phase and iturin A and fengycins during the stationary phase. [less ▲]

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See detailProbabilistic design of power-system special stability controls
Wehenkel, Louis ULg; Lebrevelec, Cyril; Trotignon, Marc et al

in Control Engineering Practice (1999), 7(2), 183-194

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and ... [more ▼]

A probabilistic approach to the design of power-system special stability controls is presented here. Using Monte-Carlo simulations, it takes into account all the potential causes of blackouts, slow and fast dynamics, and modeling uncertainties. A large number of scenarios are simulated in parallel by time-domain numerical integration, and the relevant parameters of the resulting system trajectories are stored in a database. Data-mining tools are used to identify the most important system weaknesses and possible improvements. The approach is tested on a large-scale study on the SouthÐEastern part of the extra-high-voltage system of Electricité de France. [less ▲]

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See detailL'ostéoarthrose chez le chien - Pathophysiologie et diagnostic
Loneux, P.; Balligand, Marc ULg

in Annales de Médecine Vétérinaire (1999), (143), 153-160

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See detailSolid phase extraction : An alternative to the use of rotary evaporators for solvent removal in the rapid formulation of PET radiopharmaceuticals
Lemaire, Christian ULg; Plenevaux, Alain ULg; Aerts, Joël ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1999), 42(1), 63-75

Solid phase extraction (SPE) was used for the formulation of several radiopharmaceuticals. The method involves dilution of the previously purified HPLC compound with water, trapping of the activity on an ... [more ▼]

Solid phase extraction (SPE) was used for the formulation of several radiopharmaceuticals. The method involves dilution of the previously purified HPLC compound with water, trapping of the activity on an SPE bed, washing off the support, elution of the radiopharmaceutical with a small volume of ethanol (<1 mL) and dilution with sterile isotonic saline solution. Recovery of the radiopharmaceuticals was always higher than 97%. Two different methods of automation were developed for the formulation of [11C] and [18F]radiopharmaceuticals. In all cases, organic solvent levels in the injectable solution were below the recommended limits. This fast (3-6 min.) and easy to automate process can be considered as an alternative to the conventional methods (rotary evaporators). Copyright © 1999 John Wiley [less ▲]

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See detailHyperfractionated accelerated radiotherapy (HART) for inoperable, non metastatic non-small-cell lung carcinoma of the lung (NSCLC): result of a phase II study for patients ineligible for combination radio-chemotherapy.
Koutaissoff, S; Wellmann, D; COUCKE, Philippe ULg et al

in International Journal of Radiation, Oncology, Biology, Physics (1999), 45(5), 1151-1156

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination ... [more ▼]

Purpose: To evaluate a hyperfractionated and accelerated radiotherapy (HART) protocol in patients with inoperable non-small cell lung carcinoma (NSCLC) who were ineligible for combination radiochemotherapy studies. Methods and Materials: From February 1989 through August 1994, 23 patients ineligible for available combined modality protocols in our institution were enrolled and treated with HART, consisting of 63 Gy given in 42 fractions of 1.5 Gy each, twice daily, with a minimum time interval of 6 h between fractions, 5 days a week, over an elapsed time of 4.2 weeks, or 29 days. There was no planned interruption. Results: The 1-, 2-, and 3-year survival rates were 61%, 39%, and 19%, respectively, with a median survival of 16.8 months. At the time of analysis, 4 patients are alive and 19 have died, 16 from NSCLC and 3 from cardiacdisease. Overall response rate was 48%, with 22% of patients achieving a complete response and 26% a partial response. Correlation between acute response rate and survival was poor. First site of relapse was local-regional in 8 patients (35%), distant in 6 patients (26%), and local-regional and distant in 4 (17%) patients. One patient had Grade IV and 2 had Grade III esophagitis. One patient presented with chronic Grade III lung toxicity. There were no treatment-related deaths. Conclusion: In this group of 23 patients ineligible for radiochemotherapy, this HART regime was quite feasible and was followed by little toxicity. Results in this particularly poor prognosis NSCLC patient category should be compared to series with a similar patient profile; however, median survival is at least similar to that obtained in recent series of combination radiochemotherapy. © 1999 Elsevier Science Inc. [less ▲]

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See detailLa nouvelle procédure contentieuse en matière de taxes provinciales et communales
Orban, Lionel ULg

in Actualités du Droit (1999)

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See detailRelationships between pain indicators derived from VAS measurements and analgesics consumption
Boogaerts, Jean; SEIDEL, Laurence ULg; Albert, Adelin ULg et al

in Anesthesiology (1999)

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See detailCanopy gap morphology determinants in an Amazonian rain forest.
Salvador-Van Eysenrode, D; Bogaert, Jan ULg; Impens, I

in Selbyana (1999), 20(2), 339-344

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See detailFlora and vegetation of Turtell V, Turtell Islands group (Queensland, Australia).
De Sloover, Jacques; Dufrêne, Marc ULg

in Bulletin du Jardin Botanique National de Belgique = Bulletin van de Nationale Plantentuin van België (1999), 67

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See detailAu sujet des cratères lunaires et d'un astronome montois...
Biémont, Emile ULg; Frémat, Y.; Palmeri, P. et al

in Galactée (1999), 16

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See detailSurveillance d'une maladie de Crohn en rémission de l'adulte
Belaiche, Jacques ULg; Louis, Edouard ULg

in Hépato-Gastro (1999), 6

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See detailComment j'explore ... les troubles de la calcémie
Janssens, Lise; Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1999), 54(9), 764-769

Mechanisms for calcium homeostasis are complex but their understanding is important before investigating the calcium disorders. Hypercalcaemia is often due to hyperparathyroidism or cancers. The ... [more ▼]

Mechanisms for calcium homeostasis are complex but their understanding is important before investigating the calcium disorders. Hypercalcaemia is often due to hyperparathyroidism or cancers. The diagnostis must thus be rapid and a treatment decided in a global approach. Hypocalcaemia, more frequently noted, is often due to a general disorder with hypoalbuminemia or chronic renal failure. [less ▲]

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See detailEtude des hypothèses de l'analyse de la variance à deux critères de classification : approche par l'exemple
Iemma, A. F.; Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1999), (3), 36

By examples and results from SAS and Minitab softwares (GLM), analysis of variance hypothesis built to analyse a two dimensional data table are introduced.

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See detailGalectin-1 Expression in Prostate Tumor-Associated Capillary Endothelial Cells Is Increased by Prostate Carcinoma Cells and Modulates Heterotypic Cell-Cell Adhesion
Clausse, Nathalie; van den Brule, Frédéric; Waltregny, David ULg et al

in Angiogenesis (1999), 3(4), 317-25

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host ... [more ▼]

Besides providing tumors with nutrients, newly formed capillaries constitute a potential escape route for tumor cells favoring metastatic dissemination, and constitute an access for the anti-tumoral host immune cells. Galectin-1, a soluble human lectin, is involved in numerous biological functions including cell-cell and cell-substrate interactions. In addition, galectin-1 is able to induce apoptosis of activated T-lymphocytes. In this study, we have examined galectin-1 expression in capillaries associated to the carcinoma cells or present in the remote non-tumoral stroma of 100 human prostate carcinoma samples by immunoperoxidase staining. Galectin-1 was expressed by endothelial cells from capillaries infiltrating the tumor tissue in 64% (64/100) of the cases. On the contrary, endothelial cells in the adjacent non-tumoral stroma expressed galectin-1 in very few cases (7/100). Increased frequency of galectin-1-positive capillaries in the tumor-associated compared to the tumor-free areas was observed in 63% of the cases. This striking contrast led us to set up an in vitro model to test whether tumor cells could induce galectin-1 expression by endothelial cells. Incubation of human umbilical vein endothelial cells with conditioned media from PC-3 or DU 145 prostate carcinoma cells led to a significant increase of galectin-1 protein expression (+32.97% and 37.91% P < 0.01 and P < 0.05, respectively). PC-3 conditioned medium also induced increased adhesion values of PC-3 cells to the endothelial cells (53.4 +/- 4.7 vs. 38.5 +/- 3.5 after 30 min; 66.6 +/- 7.8 vs. 46.2 +/- 6.4 after 60 min). An anti-galectin-1 antiserum abolished this modulation, and recombinant galectin-1 also induced increased adhesion values in a dose-dependent fashion. This effect was specific as no such modulations were observed using normal lymphocytes instead of PC-3 cells. Preferential galectin-1 expression in the endothelial cells close to the cancer cells could provide these latter with increased abilities to interact with the endothelial cells as well as a defense against the host immune system. [less ▲]

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See detailParticularités de la contraction électro-induite : implications rééducatives
Vanderthommen, Marc ULg; Zahlan, O.; BAUVIR, Philippe ULg et al

in Kine 2000 (1999), 10

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See detailServitude légale d'enclave : introduction de l'action et conciliation préalable obligatoire
Lecocq, Pascale ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1999)

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See detailA targeted deletion of a region upstream from the Jkappa cluster impairs kappa chain rearrangement in cis in mice and in the 103/bcl2 cell line
Cocea, L.; De Smet, A.; Saghatchian, M. et al

in Journal of Experimental Medicine (1999), 189

We have shown previously that a mutation of the KI-KII site immediately 5' to J(kappa)1 on the mouse immunoglobulin light chain kappa locus reduces the rearrangement level in cis, although it does not ... [more ▼]

We have shown previously that a mutation of the KI-KII site immediately 5' to J(kappa)1 on the mouse immunoglobulin light chain kappa locus reduces the rearrangement level in cis, although it does not affect transcription. Here we deleted by homologous recombination in mouse embryonic stem cells a 4-kb DNA fragment, located immediately upstream of the KI-KII element, which contains the promoter of the long germline transcript. Analysis of gene-targeted heterozygous mouse splenic B cells showed a strong decrease in rearrangement for the allele bearing the deletion. When both the KI-KII mutation and the 4-kb deletion were present on the same allele, the overall reduction in rearrangement was stronger than with the 4-kb deletion alone underlying the role of these two elements in the regulation of rearrangement. The same deletion was performed by homologous recombination on one allele of the rearrangement-inducible mouse 103/bcl2-hygro(R) pre-B cell line, and resulted in a similar reduction in the induction of rearrangement of the mutated allele. This result validates this cell line as an in vitro model for studying the incidence of gene-targeted modifications of the kappa locus on the regulation of rearrangement [less ▲]

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See detailRadiative lifetimes in La III and oscillator strengths in La III and Lu III
Biémont, Emile ULg; Li, Z. S.; Palmeri, P. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1999), 32

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See detailOsmotic environment of Phaseolus polyanthus Greenm. and P. vulgaris L. embryos during early development
Geerts, P.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Bean Improvement Cooperative (1999), (42), 83-84

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See detailPutrescine metabolism in a fully habituated nonorganogenic sugar beet callus and its relationship with growth
Kevers, Claire ULg; Bisbis, Badia; Faivre-Rampant, Odile et al

in Journal of Plant Physiology (1999), 154(4), 503-508

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain ... [more ▼]

A fully-habituated and nonorganogenic (HNO) sugar beet callus was previously shown to overproduce polyamines, as compared with a normal (N) auxin- and cytokinin-dependent callus of the same strain. Because relationships were established between polyamine levels and metabolism with different growth and development processes, some key enzymes in the metabolic pathways of polyamines were investigated in the HNO callus, and their involvement in growth appraised. Putrescine was found to be the major free and conjugated polyamine in the HNO callus. It was biosynthesised preferentially via ornithine and ornithine decarboxylase (ODC), which is in agreement with the surplus of synthesised ornithine. Diamine (DAO) and polyamine (PAO)-oxidase activities were also highest in the HNO callus, as compared with the normal, with DAO being the more active. Transglutaminase activities (+/- Ca) were also higher in HNO than in normal callus. Addition of different polyamines or of inhibitors of their biosynthesis to the culture medium of the HNO callus modified the level of endogenous polyamines and affected callus growth. The results thus pointed out a higher polyamine metabolism, particularly of putrescine, in the actively growing auxin- and cytokinin-independent callus than in the normal one. They also provided evidence for the sensitivity of a habituated tissue type towards this class of growth regulators. [less ▲]

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See detailA reference value for the interior-to-edge ratio of isolated habitats.
Bogaert, Jan ULg; Van Hecke, P; Impens, I

in Acta Biotheoretica (1999), 47(1), 67-77

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See detailSimultaneous Reactivation of Herpes Simplex Virus and Varicella-Zoster Virus in a Patient with Idiopathic Thrombocytopenic Purpura
Nikkels, Arjen ULg; Frere, P.; Rakic, L. et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1999), 199(4), 361-364

Simultaneous reactivation of distinct Herpesviridae with development of clinical manifestations is exceptional. We report a 48-year-old woman suffering from idiopathic thrombocytopenic purpura. As the ... [more ▼]

Simultaneous reactivation of distinct Herpesviridae with development of clinical manifestations is exceptional. We report a 48-year-old woman suffering from idiopathic thrombocytopenic purpura. As the disease remained refractory to corticosteroids, immunoglobulins and splenectomy, a cure of vinblastine was administered. An atypical stomatitis developed few days later. Immunohistochemistry on a Tzanck smear and a biopsy evidenced a Herpes simplex virus type 1 (HSV-1) infection. The patient presented simultaneously a single necrotic lesion on the abdomen. Immunohistochemistry on a skin biopsy revealed the presence of the varicella-zoster virus (VZV) gE, gB and IE63 proteins. Intravenous aciclovir was initiated. The present case of simultaneous clinical infections by HSV-I and VZV underlines the importance of complementary viral identification testing in the event of unusual clinical presentations. [less ▲]

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See detailGosferia, a new name for Forgesia Gerrienne (Fossil).
Gerrienne, Philippe ULg

in Taxon (1999), 48

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See detailFauna vs flora contribution to the leaf epiphytes biomass in a Posidonia oceanica seagrass bed (Revellata Bay, Corsica).
Lepoint, Gilles ULg; Havelange, Stéphane; Gobert, Sylvie ULg et al

in Hydrobiologia (1999), 394

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the ... [more ▼]

The epiphyte biomass of Posidonia oceanica (L.) Delile leaves is mainly related to the substrate leaf availability. It decreases with increasing depth and increases from winter to summer, following the leaf biomass changes. In Revellata Bay (Gulf of Calvi, Corsica), at shallow depth (10m in this study) where photophilous algae grow, the fixed epifauna biomass accounts for about one third of leaf epiphytes biomass. At deeper depths in the Revellata Bay (20 and 30m), where shade-tolerant algae are dominant among epiflora, epifauna may account for more than half the leaf epiphytes biomass. [less ▲]

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See detailCyanide-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration during postharvest ripening of tomato fruit
Almeida, A.; Jarmuszkiewicz, W.; Khomsi, H. et al

in Plant Physiology (1999), 119

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We ... [more ▼]

Tomato (Lycopersicon esculentum) mitochondria contain both alternative oxidase (AOX) and uncoupling protein as energy-dissipating systems that can decrease the efficiency of oxidative phosphorylation. We followed the cyanide (CN)-resistant, ATP-synthesis-sustained, and uncoupling-protein-sustained respiration of isolated mitochondria, as well as the immunologically detectable levels of uncoupling protein and AOX, during tomato fruit ripening from the mature green stage to the red stage. The AOX protein level and CN-resistant respiration of isolated mitochondria decreased with ripening from the green to the red stage. The ATP-synthesis-sustained respiration followed the same behavior. In contrast, the level of uncoupling protein and the total uncoupling-protein-sustained respiration of isolated mitochondria decreased from only the yellow stage on. We observed an acute inhibition of the CN-resistant respiration by linoleic acid in the micromolar range. These results suggest that the two energy-dissipating systems could have different roles during the ripening process. [less ▲]

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See detailLa petite musique d'Isabelle Stengers. Entretien avec une philosophe de l'invention
Havelange, Carl ULg; Despret, Vinciane ULg

in Le Carnet et les Instants (1999), juillet-décembre 1999(16 (paru en 2001)), 10-16

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See detailPhenotypic variation in live weight and live-weight changes of lactating Holstein-Friesian cows
Koenen, Epc.; Groen, Af.; Gengler, Nicolas ULg

in Animal Science (1999), 68

This study quantified individual phenotypic variation in live weight and live-weight changes during the first three lactations and estimated the effects of age, lactation week and pregnancy on live weight ... [more ▼]

This study quantified individual phenotypic variation in live weight and live-weight changes during the first three lactations and estimated the effects of age, lactation week and pregnancy on live weight. Data comprised weekly averaged live weight (calculated from daily observations) during 452 lactations of 239 Holstein-Friesian cows. Unadjusted mean live weights were 553 (s.d. 50), 611 (s.d. 55) and 654 (s.d. 57) kg during first, second and third parity, respectively. Estimated effect of growth during parity was 46, 52 and 23 kg for the first three parities. Mean maximum weight loss was 26, 22 and 22 kg for first, second and third parity and variation was large among individuals. Week of lactation when cows had their maximum weight loss ranged from 7 weeks in first lactation to 13 weeks in third lactation. Estimated maximum effect of pregnancy on live weight during the lactation varied from 27 to 59 kg. Phenotypic variance in live weight increased with parity. Repeatabilities of live-weight observations within parity were 0.85. Across parities, high repeatabilities were found for calving weight and mean live weight but not for parameters associated with maximum weight loss. Correlations between weekly means and mean live weight during the whole of lactation were high. It was concluded that single live-weight observations of heifers are a good measurement of mean live weight during the first three parities. [less ▲]

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See detailConnectionist symbol processing : dead or alive ?
Blank, D. S.; Coltheart, M.; Diederich, J. et al

in Neural Computing Surveys (1999), 2

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See detailHow To Bring Orphan Genes Into Functional Families
Bianchi, Mm.; Sartori, G.; Vandenbol, Micheline ULg et al

in Yeast (1999), 15(6),

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See detailThe effect of training on the calcified zone of equine middle carpal articular cartilage
Murray, R. C.; Whitton, R. C.; Vedi, S. et al

in Equine Veterinary Journal. Supplement (1999), 30

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is ... [more ▼]

Carpal osteochondral injury is frequently observed in strenuously trained horses. It is clear that the integrity of articular cartilage and subchondral bone are intimately related, although there is controversy about which component is the most important. Calcified cartilage provides the mechanical link between soft hyaline cartilage and stiff subchondral bone so it is essential to understand the tissue's response to exercise. Middle carpal calcified and uncalcified (hyaline) cartilage thickness was investigated in horses undergoing high- and low-intensity exercise. Twelve untrained horses (18-21 months) were paired, and randomly assigned to an exercise group. Group 1 underwent 19 weeks progressive high-intensity training on a high-speed treadmill. Group 2 underwent walking exercise only. Osteochondral specimens were obtained from 8 test sites per carpus immediately after euthanasia. Histomorphometric measurements of total cartilage, hyaline layer, and calcified zone thickness were obtained from decalcified and undecalcified samples. Mean +/- s.d. (micron) calcified cartilage thickness for dorsal cartilage from Group 1 was 271 +/- 73 and from Group 2 was 163 +/- 49; for palmar cartilage from Group 1 was 195 +/- 42 and Group 2 was 150 +/- 52. Group 1 horses had significantly thicker total cartilage (P < 0.0001) and calcified zone (P < 0.0001) than Group 2, but there was no difference in hyaline layer. Within each group all dorsal sites had thicker calcified cartilage (P < 0.003) than palmar sites, but no difference in hyaline or total cartilage. These findings indicate that high-intensity exercise leads to greater calcified zone depth without alteration in hyaline cartilage thickness, and that this response is maximal at sites that withstand high, intermittent loads. Increasing calcified cartilage thickness with exercise may maintain the articular surface stiffness gradient in the face of alterations in hyaline cartilage and/or subchondral bone stiffness [less ▲]

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See detailHaftung des säumigen Schuldners für Zufall. Von Gaius (D.16.3.14.1) bis zum Code civil
Gerkens, Jean-François ULg

in Tradition und Fortschritt im Recht, Jahrbuch Junger Zivilrechtswissenschaftler (1999)

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See detailUn goût de lire bien mesuré: Elaboration et mise à l'essai d'une échelle d'attitudes envers la lecture
Lafontaine, Dominique ULg

in Mesure et Evaluation en Education [=MEE] (1999), 22(1), 21-43

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See detailLes mesures provisoires en droit commercial international : développements récents au regard des Conventions de Bruxelles et de Lugano
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1999)

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See detailQu'est-ce que bien enseigner ? : éléments de réponse suggérés par la psychologie cognitive
Crahay, Marcel ULg

in Réflexions (1999), (36039), 19-23

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See detailAdjuvant small field pelvic radiation for patients with high risk, stage IB lymph node negative cervix carcinoma after radical hysterectomy and pelvic lymph node dissection. A pilot study.
KRIDELKA, Frédéric ULg; Berg, D. O.; Neuman, M. et al

in Cancer (1999), 86(10), 2059-65

BACKGROUND: After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix ... [more ▼]

BACKGROUND: After radical hysterectomy and pelvic lymph node dissection, an identifiable subgroup of patients with International Federation of Gynecology and Obstetrics Stage IB lymph node negative cervix carcinoma remains at high risk of pelvic recurrence. This study attempted to determine whether postoperative small field of pelvic radiation can improve the disease free survival (DFS) of this high risk group of patients without producing significant morbidity. METHODS: Between 1991 and 1995, after radical surgery, 25 patients with Stage IB lymph node negative cervix carcinoma were considered to be at high risk of pelvic recurrence on the basis of tumor dimension, depth of stromal invasion, and the presence of lymph-vascular space invasion. All had a score >/= 120 as determined by the Gynecologic Oncology Group (GOG) study. These patients received 50.4 gray of adjuvant radiation to a small central pelvic field and were followed prospectively. A Kaplan-Meier 5-year DFS curve was generated. A log rank analysis produced an estimated log rank P value (est P value) by comparing the 5-year DFS of the patients in the current study with the 5-year DFS of the corresponding high risk group of the GOG study (observation only). The morbidity of small field pelvic radiation was recorded. RESULTS: Among the 25 patients who received small field pelvic radiation, the mean GOG score was 166 (range, 120-263) and the mean follow-up was 32 months (range, 12-64 months). There was 1 recurrence (4%) recorded at 16 months. The log rank analysis demonstrated a significant improvement in the 5-year DFS for the group who received adjuvant small field pelvic radiation (est P value = 0.005) when compared with the DFS of the high risk GOG patients who were observed postoperatively. Four cases of minor morbidity were recorded: lymphedema (three cases) and mild rectal incontinence (one case). No major morbidity was reported. CONCLUSIONS: With low morbidity, adjuvant small field pelvic radiation appears to improve significantly the 5-year DFS of patients with high risk, lymph node negative Stage IB cervical carcinoma. However, this pilot study requires verification. [less ▲]

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See detailL'effet dévolutif de l'appel et le sort en degré d’appel des déclinatoires de la compétence du juge siégeant en référé et comme en référé en matière commerciale
Boularbah, Hakim ULg

in Revue de Droit Commercial Belge [= RDC] = Tijdschrift voor Belgisch Handelsrecht [=TBH] (1999)

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See detailDe la tierce décision obligatoire
Caprasse, Olivier ULg

in Journal des Tribunaux (1999)

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See detailStructure of high-temperature fluid selenium
Raty, Jean-Yves ULg; Saul, A.; Gaspard, Jean-Pierre ULg et al

in Physical Review. B : Condensed Matter (1999), 60(4), 2441-24482448

A semiempirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces that proves necessary at the liquid ... [more ▼]

A semiempirical tight-binding energy model is developed for selenium. It includes s and p electrons as well as an empirical description of the dispersion forces that proves necessary at the liquid densities under study. The band-structure parameters are obtained by fitting abinitio calculations. The simulated liquid structures are in very good agreement with the most recent X-ray scattering and extended X-ray absorption fine-structure experiments in a broad temperature and density range. The Monte Carlo simulations performed show that the complex liquid structures observed result from the breaking and branching of the selenium chains. The total coordination number is shown to result from the balance between one-, two-, and threefold coordinated atoms. The role of these defects is discussed in relationship with the electrical conductivity of the liquid, i.e., the semiconductor-metal and metal-nonmetal transitions observed at high pressures [less ▲]

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See detailLeft inferior frontal cortex is involved in probabilistic serial reaction time learning
Peigneux, Philippe ULg; Maquet, Pierre ULg; Van der Linden, Martial ULg et al

in Brain and Cognition (1999), 40(1), 215-219

Cerebral blood flow was estimated using positron emission tomography and H2O15 infusions in 12 volunteers while they were trained on the probabilistic serial reaction time task developed by Jimenez ... [more ▼]

Cerebral blood flow was estimated using positron emission tomography and H2O15 infusions in 12 volunteers while they were trained on the probabilistic serial reaction time task developed by Jimenez, Mender, and Cleeremans (1996). Participants' reaction rimes to predictable and nonpredictable stimuli showed increasing sensitivity to the: probabilistic constraints set by previous elements of the sequence. Analysis by statistical parametric mapping showed a significant interaction between participants' performance and time effect in the left inferior frontal cortex. Our results provide the first evidence of this cerebral area being involved in the processing of contextual information in a probabilistic sequence learning task. [less ▲]

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See detailBisphosphonates : an update
Reginster, Jean-Yves ULg

in Osteologia-Osteology (1999), 2

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See detailIncreased aortic compliance and energetic cost of cardiac ejection
Kolh, Philippe ULg; LAMBERMONT, Bernard ULg; GERARD, P et al

in Acta Cardiologica (1999), 53(6), 387

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See detailBovine brucellosis diagnosis by skin test: conditions for its use and evaluation of its performance
Saegerman, Claude ULg; Vo, T. K. O.; De Waele, L. et al

in Veterinary Record : Journal of the British Veterinary Association (1999), 145

Brucellergene OCB (Rhône-Mérieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin ... [more ▼]

Brucellergene OCB (Rhône-Mérieux) was used as an allergen to define the intrinsic parameters of a skin test and to compare its properties with serology for the diagnosis of bovine brucellosis. The skin test was also evaluated for its capacity to solve problems associated with false positive reactions in serological tests. The optimal reading delay for the skin test was 72 hours. The brucellosis allergic reaction was two to three times less intense than the tuberculosis allergic reaction. An increase of 1.1 mm or more in the skin thickness was therefore considered to be an adequate cut-off. The specificity calculated for 1192 brucellosis-free animals (including animals from brucellosis-free herds in which false positive serological reactions had been reported) was 99-83 per cent (95 per cent confidence interval [CI] 99-40 to 99-98 per cent). The sensitivity determined from 27 experimentally infected heifers ranged from 93 per cent (95 per cent CI 76 to 100 per cent) to 78 per cent (95 per cent CI 58 to 91 per cent) when measured respectively one and six months after the infection. Allergic reactions could be detected in vaccinated animals up to four-and-a-half years after the vaccination. On the other hand, no sensitisation was recorded in naïve animals after up to eight monthly injections of the allergen. The skin test gave valuable information, in combination with the serological tests, in both acute and chronic brucellosis. The skin test discriminated brucellosis clearly from false positive serological reactions due to infections with Yersinia enterocolitica O9. [less ▲]

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See detailPrise en charge thérapeutique de la maladie de Huntington
DELVAUX, Valérie ULg; Schoenen, Jean ULg

in Ahead in Neurology (1999), 3(2), 13-16

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See detailDescription de trois cas autochtones de babésiose canine (Babesia canis) en Belgique
Losson, Bertrand ULg; Mollet, J. J.; Avez, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailProfil de l'état corporel au cours du post partum chez la vache laitière
Drame, Daour; Hanzen, Christian ULg; Houtain, J. Y. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailPrevalence of hepatitis G virus in a haemodialysis unit
Lamproye, Anne ULg; Delwaide, Jean ULg; Vaira, Dolorès ULg et al

in Acta Gastro-Enterologica Belgica (1999), 62(1), 13-15

Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more ... [more ▼]

Background : Recently, a novel blood-borne virus has been identified and named hepatitis G virus. Transfusion is the main route of transmission. It is known that patients on maintenance dialysis are more susceptible to infections with parenterally-transmitted viruses than the general population. The aim of the present study was to determine the prevalence of hepatitis G infection in a Belgian dialysis unit. Methods: The entire population of our dialysis unit (82 patients) was tested for the presence of hepatitis G virus (HGV) by reverse transcriptase polymerase chain reaction. History of transfusion or renal transplantation coinfections with hepatitis B and C viruses, and serum aminotransferase levels were also tested. Results: Thirteen patients (16%) were found positive for HGV-RNA. Among these patients, 69.2% were infected by the G virus alone, 15.4% were coinfected with B virus, and 15.4% with C virus. All but one patient had a history of transfusion. Ten of the thirteen infected patients (77%) had normal aminotransferase (< 30 UI/l). Three patients had elevated aminotransferase levels (23%); one was coinfected with B virus, one with C virus, and the last one had a diabetes-induced fatty liver infiltration. No liver biopsies were performed. Conclusions :It is concluded that infection with C virus is common among dialyzed patients. This high rate of infection could be related to previous transfusions, but may as well be due to nosocomial transmission. In our series, at least one patient has been contaminated by another road than transplantation or transfusion. Finally, it does not appear clearly that chronic infection with hepatitis G virus induces Liver disease, as defined by elevated aminotransferase level. [less ▲]

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See detailA study of within-laboratory variability based on data from the Belgian External Quality Assessment (EQA) programme
Zhang, Lixin; Albert, Adelin ULg; Hamers, N. et al

in Clinical Chemistry (1999), 45(6)

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