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See detailLa calcitonine
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1996), 51(1), 116-9

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See detailLes facteurs de croissance hematopoiétiques
Fillet, Georges ULg

in Revue Médicale de Liège (1996), 51(1), 102-6

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See detailEffects of Testosterone and Its Metabolites on Aromatase-Immunoreactive Cells in the Quail Brain: Relationship with the Activation of Male Reproductive Behavior
Balthazart, Jacques ULg; Foidart, Agnès ULg; Absil, Philippe ULg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 185-200

The enzyme aromatase converts testosterone (T) into 17 beta-estradiol and plays a pivotal role in the control of reproduction. In particular, the aromatase activity (AA) located in the preoptic area (POA ... [more ▼]

The enzyme aromatase converts testosterone (T) into 17 beta-estradiol and plays a pivotal role in the control of reproduction. In particular, the aromatase activity (AA) located in the preoptic area (POA) of male Japanese quail is a limiting step in the activation by T of copulatory behavior. Aromatase-immunoreactive (ARO-ir) cells of the POA are specifically localized within the cytoarchitectonic boundaries of the medial preoptic nucleus(POM), a sexually dimorphic and steroid-sensitive structure that is a necessary and sufficient site of steroid action in the activation of behavior. Stereotaxic implantation of aromatase inhibitors in but not around the POM strongly decreases the behavioral effects of a systemic treatment with T of castrated males. AA is decreased by castration and increased by aromatizable androgens and by estrogens. These changes have been independently documented at three levels of analysis: the enzymatic activity measured by radioenzymatic assays in vitro, the enzyme concentration evaluated semi-quantitatively by immunocytochemistry and the concentration of its messenger RNA quantified by reverse transcription-polymerase chain reaction (RT-PCR). These studies demonstrate that T acting mostly through its estrogenic metabolites regulates brain aromatase by acting essentially at the transcriptional level. Estrogens produced by central aromatization of T therefore have two independent roles: they activate male copulatory behavior and they regulate the synthesis of aromatase. Double label immunocytochemical studies demonstrate that estrogen receptors(ER) are found in all brain areas containing ARO-ir cells but the extent to which these markers are colocalized varies from one brain region to the other. More than 70% of ARO-ir cells contain detectable ER in the tuberal hypothalamus but less than 20% of the cells display this colocalization in the POA. This absence of ER in ARO-ir cells is also observed in the POA of the rat brain. This suggests that locally formed estrogens cannot control the behavior and the aromatase synthesis in an autocrine fashion in the cells where they were formed. Multi-neuronal networks need therefore to be considered. The behavioral activation could result from the action of estrogens in ER-positive cells located in the vicinity of the ARO-ir cells where they were produced (paracrine action). Alternatively, actions that do not involve the nuclear ER could be important. Immunocytochemical studies at the electron microscope level and biochemical assays of AA in purified synaptosomes indicate the presence of aromatase in presynaptic boutons. Estrogens formed at this level could directly affect the pre-and post-synaptic membrane or could directly modulate neurotransmission namely through their metabolization into catecholestrogens (CE) which are known to be powerful inhibitors of the catechol- omicron - methyl transferase (COMT). The inhibition of COMT should increase the catecholaminergic transmission. It is significant to note, in this respect, that high levels of 2-hydroxylase activity, the enzyme that catalyzes the transformation of estrogens in CE, are found in all brain areas that contain aromatase. On the other hand, the synthesis of aromatase should also be controlled by estrogens in an indirect, transynaptic manner very reminiscent of the way in which steroids indirectly control the production of LHRH. Fibers that are immunoreactive for tyrosine hydroxylase (synthesis of dopamine), dopamine beta-hydroxylase (synthesis of norepinephrine) or vasotocine have been identified in the close vicinity of ARO-ir cells in the POM and retrograde tracing has identified the origin of the dopaminergic and noradrenergic innervation of these areas. A few preliminary physiological experiments suggest that these catecholaminergic inputs regulate AA and presumably synthesis. [less ▲]

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See detailLes fluoroquinolones
Damas, Pierre ULg

in Revue Médicale de Liège (1996), 51(1), 50-52

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See detailLes anti-inflammatoires non stéroïdiens
Malaise, Michel ULg

in Revue Médicale de Liège (1996), 51(1), 123-125

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See detailTrophoblast-specific processing and phosphorylaton of pregnancy-associated glycoprotein-1 in day 15 to 25 sheep placenta
Xie, S.; Nagel, R. J.; Green, J. et al

in Biology of Reproduction (1996), 54(1), 122-129

Bovine and ovine pregnancy-associated glycoproteins-1 (PAG-1) are products of binucleate trophoblast cells and belong to the aspartic proteinase gene family. Estimates of their relative molecular masses ... [more ▼]

Bovine and ovine pregnancy-associated glycoproteins-1 (PAG-1) are products of binucleate trophoblast cells and belong to the aspartic proteinase gene family. Estimates of their relative molecular masses have varied considerably, from 47 to 90 kDa, even though the mature polypeptide has been inferred to be no more than 330 amino acids in length and that the glycosylated recombinant form synthesized in Chinese hamster ovary (CHO) or COS-1 cells had an apparent mass of 46 kDa. To establish the relationships among the various molecular forms, metabolic labeling, immunoprecipitation, and electrophoretic analysis were used to follow the biosynthesis of ovine PAG-1 (ovPAG-1) in placental explants. In time-course studies, ovPAG-1 could first be detected within 10 min as a 70-kDa form within the tissue. With time, forms of intermediate (53-61 kDa) and low (47 kDa) molecular mass began to accumulate. The latter predominated in medium after 6 h labeling. Pulse chase studies established that the 70-kDa forms were the precursors of the smaller species. Inhibition of glycosylation with tunicamycin or treatment with N-glycosidase F confirmed that ovPAG-1 contained N-linked oligosaccharide chains, but that this carbohydrate accounted for only a relatively small fraction (8-10 kDa) of the apparent mass. Consecutive treatment with neuraminidase and O-glycanase also reduced the apparent molecular mass of the precursor by approximately 11 kDa. OvPAG-1 incorporated 32P from [32P]orthophosphate into phosphoserine and phosphothreonine, but there was no incorporation of 35S from [35S]sulfate. The basis of the differences in molecular mass between the precursor and the final products remains to be elucidated, but the differences seem likely to be due to some unusual form of posttranslational modification introduced in the binucleate cell. The results of the study appear to explain the disparate size values that have been reported for these placenta-derived proteins. [less ▲]

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See detailLes bisphosphonates
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (1996), 51(1), 120-2

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See detailHistoire et perspective du traitement par diurétiques
Krzesinski, Jean-Marie ULg

in Revue Médicale de Liège (1996), 51(1), 30-34

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces ... [more ▼]

Les diurétiques ont été utilisés avec succès en clinique depuis plus de 70 ans. Les diurétiques mercuriels ont constitué la première étape importante dans le développement des diurétiques modernes. Ces dernières années, suite au développement de nouvelles options thérapeutiques, les diurétiques ont été décriés en raison de quelques effets secondaires. Cette classe thérapeutique reste cependant un pilier solide et incontournable dans les états de rétention hydrosodée comme par exemple la décompensation cardiaque ou dans l'hypertension artérielle du sujet âgé. Quoi qu'il en soit, le développement de nouveaux diurétiques vit au ralenti en raison de l'acceptation relativement faible de nouvelles molécules, commercialisées pourtant à très faible dose, c'est-à-dire sans action principale sur la volémie. Les modulateurs du transport d'ions, dérivés des structures moléculaires non diurétiques parmi les familles de diurétiques ouvrent cependant des voies intéressantes dans le traitement de maladies diverses. [less ▲]

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See detailThe seasonality of the CO2 exchange between the atmosphere and the land biosphere: A study with a global mechanistic vegetation model
Nemry, B.; François, Louis ULg; Warnant, Pierre ULg et al

in Journal of Geophysical Research (1996), 101(D3), 7111-7125

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR ... [more ▼]

Two simulations of the seasonal variation of the global atmospheric CO2 distribution are obtained by combining an atmospheric transport model, two parameterizations of soil heterotrophic respiration (SHR), and a mechanistic model of carbon assimilation in the biosphere (CARAIB) that estimates the net primary production (NPP) of continental vegetation. The steady state hypothesis of the biosphere allows the spatial distribution and the global content of the soil carbon to be expressed as a function of the root fractions of soil respiration under forested and herbaceous vegetation covers. The sensitivity of the modeled CO2 signal to the wind field does not exceed the observed interannual variability. The influence of the various vegetation zones is quantified by the Fourier analysis of the modeled atmospheric signal. In the northern hemisphere, the temperate ecosystems dominate the seasonal atmospheric signal of the extratropical latitudes. The ecosystems of the tropical northern zone determine the local signal, while the southern tropical ecosystems influence largely the signal in the whole southern hemisphere. The results give credence to the mechanistic modeling of NPP since the simulated atmospheric signal is comparable with that obtained with normalized difference vegetation index (NDVI) based diagnostic models coupled with a parameterization of SHR fitted to optimize the atmospheric signal. [less ▲]

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See detailChemotaxis-Promoting and Adhesion Properties of Human Tonsillar Follicular Dendritic Cell Clusters
Bouzahzah, F.; Antoine, Nadine ULg; Simar, Léon ULg et al

in Research in Immunology (1996), 147(3, Mar-Apr), 165-73

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role ... [more ▼]

Lymph follicles are globular and compact due to aggregation of lymphoid cells on follicular dendritic cells (FDC). To probe the mechanisms underlying this accumulation of cells, we analyse here the role played by FDCs in attracting and binding cells. FDCs prepared from human tonsils by mild separation techniques appeared in the form of clusters (FDC clusters), where, via cytoplasmic extensions, they enveloped lymphoid cells. Using Boyden's chambers, we demonstrated that these FDC clusters produced one or more chemoattractants capable of inducing chemotaxis of lymphoid cells. Supernatants of FDC cluster cultures also exerted a chemotaxis-promoting effect. FDC clusters induced true chemotaxis, not merely chemokinesis due to cell activation. They secreted a substance or substances that stuck to the substrate (a cellulose filter) and thus induced haptotaxis. B as well as T cells were attracted, but B cells apparently required the presence of T cells to respond fully to the chemoattractant(s). Subtypes of B cells (IgD+ and IgD-) and T cells (CD4+, CD8+, CD57+ AND CD57-) were tested and all were attracted. Since purified lymphoid cells did not induce these phenomena, FDCs were suspected to do so. FDCs have been shown to establish contact with lymphoid cells. Here we have determined that CD4+ T cells adhere in greater number to FDC clusters than do CD8+ T cells. We thus propose that FDCs specifically contribute to construction of lymph follicles by attracting and determining their cell composition. [less ▲]

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See detailFréquence et importance du charriage dans des rivières à charge de fond graveleuse
Petit, François ULg; Pauquet, A.; Pissart, Albert ULg

in Géomorphologie : Relief, Processus, Environnement (1996)

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See detailParcours d’un chartiste : Robert-Henri Bautier et le recueil de ses articles
Marchandisse, Alain ULg

in Moyen Age (Le) (1996), 102

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See detailLe campus universitaire comme espace public : des représentations aux pratiques
Frankignoulle, Pierre ULg; Bodson, Edith

in Etudes de Communication (1996), 18

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See detailLa communauté des citoyens de D. Schnapper
Martiniello, Marco ULg

in New Community (1996), 22(1), 165-166

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See detailHaemodynamic dysfunctions involved in experimental bovine pneumonic pasteurellosis
Desmecht, Daniel ULg; Amory, Hélène ULg; Linden, Annick ULg et al

in Journal of Experimental Animal Science (1996), 37

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See detailEffets du massage par appareil semi automatique : Etude scintigraphique et tonométrique
Crielaard, Jean-Michel ULg; Vanderthommen, Marc ULg; Dauchat, L. et al

in Kinésitherapie, les Annales (1996), 23(3), 102-105

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See detailCellular Pathways Involved In The Ex Vivo Expression Of Bovine Leukemia Virus
Kerkhofs, P.; Adam, E.; Droogmans, L. et al

in Journal of Virology (1996), 70(4),

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See detailUne statuette d'adorant de l'âge du Bronze ancien provenant de Tell Amarna (Syrie)
Tunca, Önhan ULg

in Colloctanea Orientalia. Histoire, arts de l'espace et industrie de la terre. Etudes offertes en hommage à Agnès Spycket (1996)

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See detailCritical Evaluation of the DNA-methyl Green Assay: Application to Some Indole Alkaloids
Bonjean, K.; De Pauw-Gillet, Marie-Claire ULg; Bassleer, R. et al

in Phytotherapy Research (1996), 10

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt ... [more ▼]

A DNA-methyl green colorimetric microassay for the detection of agents that interact with DNA was assessed with reference molecules (doxorubicin, ellipticine, melinonine F, dihydroflavopereirine, cis-Pt, mitomycin C, emetine or colchicine). This test showed some promise as a screening technique for substances that intercalate partly or totally into the DNA helix but it is not suitable for substances that bind covalently to DNA. An application of this test to a number of indole alkaloids was also performed. Cryptolepine, serpentine, alstonine and matadine induced a reduction of the colour of the solution, so indicating an interaction with DNA. [less ▲]

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See detailExpression of the 27,000 mol. wt heat shock protein following kainic acid-induced status epilepticus in the rat.
Plumier, Jean-Christophe ULg; Armstrong, J. N.; Landry, J. et al

in Neuroscience (1996), 75(3), 849-56

Western analysis and immunohistochemistry were used to determine the time-course and the distribution of the 27,000 mol. wt heat shock protein, Hsp27, in rat brain following systemic administration of ... [more ▼]

Western analysis and immunohistochemistry were used to determine the time-course and the distribution of the 27,000 mol. wt heat shock protein, Hsp27, in rat brain following systemic administration of kainic acid. No Hsp27 immunoreactivity was detected in naive control animals or in rats that failed to develop status epilepticus. Hsp27 immunoreactivity was detected as early as 12 h in the parietal cortex, piriform cortex and the hippocampus of rats that developed status epilepticus. The number of cells expressing Hsp27 and the intensity of Hsp27 immunoreactivity were increased 24 h after kainic acid administration. Hsp27 immunoreactivity was still observed seven days post-kainic acid injection. The morphology of the Hsp27-positive cells and double immunofluorescence against Hsp27 and glial fibrillary acidic protein revealed that Hsp27-positive cells were astrocytes. In addition, the distribution of Hsp27 suggested that astrocytic Hsp27 was dependent on excitation-induced metabolic stress rather than the direct effect of kainic acid on astrocytes. [less ▲]

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See detailEnhancement of nuclear receptor transcriptional signalling.
Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 39-45

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which ... [more ▼]

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins. [less ▲]

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See detailNouveaux developpements en selection animale.
Burny, A.; Portetelle, Daniel ULg; Renaville, Robert ULg

in Agricontact (1996), (287),

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See detailThe Appearance of CH3+ Ions from Methyl Halides by resonant photoionization. A translational energy surprisal analysis. Part I. CH3F.
Momigny, J.; Locht, Robert ULg

in Chemical Physics (1996), 206

A surprisal analysis has been applied to the translational energy distribution (TED) of CH3++F from CH3F giving rise to a new and deeper insight into the dissociation dynamics involved in the process. For ... [more ▼]

A surprisal analysis has been applied to the translational energy distribution (TED) of CH3++F from CH3F giving rise to a new and deeper insight into the dissociation dynamics involved in the process. For both the 16.5 eV and 21.22 eV photon energies used, the direct population at different energy levels of the B2E state of CH3F+ which is radiationlessly coupled to the repulsive CH3F+(A2A1) state, gives rise to wide and negatively surprised total TEDs. At both energies they have to be ascribed to severe limitations in the vibrational excitation of CH3+. Additionally, in the case of 21.22 eV photons, a non-statistical expression has to be used to account for the density of translational states. At both photon energies, the population of the CH3F+ electronic states through autoionization of Rydberg states accounts for (i) the concurrent appearance of TEDs governed by a pure RRKM behavour and (ii) the positively surprised TEDs where the angular momentum conservation plays an important role. At 16.85 eV photon energy the distributions are assigned to CH3F+ (X2E)->CH3+ (X1A'1)+F. At 21.22 eV photon energy, doubly excited electronic states of CH3F+ are assumed to take part and they are correlated with CH3+ (3A")+F channel. [less ▲]

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See detailHydrology and fluvial dynamics, in Geography Research in Belgium, Comité National de Géographie, DENIS J. (Ed.)
Petit, François ULg

in Bulletin de la Société Belge d'Etudes Géographiques = Tijdschrift van de Belgische Vereniging voor Aardrijkskundige Studies (1996)

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See detailL'immaginario lunare
Curreri, Luciano ULg

in La Battana (1996), 120

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See detailBrain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease
Mastrogiacomo, Frank; Lindsay, J. Gordon; Bettendorff, Lucien ULg et al

in Annals of Neurology (1996), 39

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See detailActivated forms of MMP2 and MMP9 in abdominal aortic aneurysms.
SakalihasanN, Natzi ULg; Delvenne, Philippe ULg; Richelle, Betty ULg et al

in Journal of Vascular Surgery (1996), 24(1), 127-33

PURPOSE: This consistent observation of a reduction of the elastin concentration in abdominal aortic aneurysms (AAAs) has led us to investigate in AAA specimens two metalloproteinases that display ... [more ▼]

PURPOSE: This consistent observation of a reduction of the elastin concentration in abdominal aortic aneurysms (AAAs) has led us to investigate in AAA specimens two metalloproteinases that display elastase activity, MMP2 (gelatinase A/72kDa) and MMP9 (gelatinase B/92 kDa). METHODS: Samples of full-thickness aortic wall, adherent thrombus, and serum were collected in 10 patients with AAAs. Samples of normal aortic wall and serum were taken from 6 age-matched control patients. Quantitative gelatin-zymography and gelatinolytic soluble assays after acetyl-phenyl mercuric acid activation were performed on serum and tissue extracts, and the results were expressed in units on a comparative wet-weight basis. Histologic analysis was performed in parallel to score the inflammatory infiltrate. RESULTS: The luminal and parietal parts of the thrombus contained, respectively, 20- and 10-fold more gelantinolytic activity than the serum. The predominate form was MMP9. Although the total gelatinolytic activity was in the same range both in AAAs and in normal walls, a significantly higher proportion of MMP9 was found in the aneurysmal aortic walls. Furthermore, a significant proportion of MMP9 was under its processed active form, which was never observed in normal samples. A significantly higher proportion of MMP2 was also present as processed active form in AAA wall. This latter parameter positively correlated with the inflammatory score. CONCLUSIONS: The presence of activated MMP9 and MMP2 might contribute to the degradation of the extracellular matrix proteins that occurs during the development of aneurysms. [less ▲]

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See detailTreatment of osteoporosis: where are we and where are we going to
Reginster, Jean-Yves ULg

in Revista de Reumatologia (1996), 4

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See detailCosmological formation of low-mass objects
Haiman, Z.; Thoul, Anne ULg; Loeb, A.

in Astrophysical Journal (1996), 464(2), 523-538

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks ... [more ▼]

We investigate the early formation of bound objects with masses comparable to the cosmological Jeans mass (similar to 10(5) M.). We follow the growth of isolated spherically symmetric density peaks starting from the linear perturbative regime. The initial parameters correspond to density peaks of various widths and heights in a cold dark matter cosmology. We use a one-dimensional spherical Lagrangian hydrodynamics code to follow the dynamical, thermal, and nonequilibrium chemical evolution of the gas. The system includes a collisionless dark matter component and a baryonic component composed of the nine species H, H-, H+, He, He+, He++, H-2, H-2(+), and e(-). All relevant chemical reactions between these species and their cooling mechanisms are included in the calculations. We explore the dependence of the dynamical evolution of the gas on two parameters: the initial mass scale and the initial overdensity of the system. We follow the evolution of the density, temperature, and abundance profiles within the cloud, assuming two types of central boundary conditions for the collisionless component: in one the infalling dark matter virializes through a reflection from a hard sphere, while in the other it accretes onto a central sink. We find that in both cases, radiative cooling by H-2 affects the collapse dynamics of the gas only after it has already virialized and become part of the bound object. Therefore, radiative cooling is unlikely to have triggered the initial collapse of perturbations at redshifts z>10. Nevertheless, baryonic objects with masses well below the linear theory Jeans mass (less than or similar to 10(3) M.) form at high redshifts because of shell crossing by the dark matter. Such objects could be the progenitors of a primordial population of high-mass stars in the intergalactic medium. [less ▲]

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See detailInsulin-like growth factors enhance steroidogenic enzyme and corticotropin receptor messenger ribonucleic acid levels and corticotropin steroidogenic responsiveness in cultured human adrenocortical cells.
l'Allemand, D.; Penhoat, A.; LEBRETHON, Marie-Christine ULg et al

in The Journal of clinical endocrinology and metabolism (1996), 81(11), 3892-7

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation ... [more ▼]

In several species, including the human fetus, insulin-like growth factors (IGF-I and IGF-II) have been reported to modulate adrenal steroidogenesis, thus contributing to adrenal cortical differentiation. In the present study, we examined the long term effects of IGF-I and -II on human adult adrenal fasciculata-reticularis cells cultured in a chemically defined medium and compared them to the effects of insulin, human GH, and ACTH. Treatment for 3 days with IGF-I or -II at nanomolar concentrations or with insulin at micromolar concentrations slightly increased the production of androstenedione, cortisol, and dehydroepiandrosterone about 1.5-fold over that by control cells. Moreover, the acute steroidogenic response to ACTH of cells pretreated with IGF-I, IGF-II, or insulin was 3- to 6-fold higher than that of control cells. For each hormone, these effects of IGF-I and -II were dose dependent between 0.1-26 nmol/L (1-200 ng/mL). The secretion of androstenedione was more potently stimulated than that of dehydroepiandrosterone and cortisol, and this effect was more clearly yielded by pretreatment with IGF-II than with IGF-I or insulin. Human GH had no effect on these cells. In cells treated with IGF-I or -II, the messenger ribonucleic acid (mRNA) levels of cytochrome P450 17 alpha-hydroxylase and of 3 beta-hydroxysteroid dehydrogenase were increased, and the abundance of ACTH receptor mRNA was also slightly enhanced, but the mRNA of cytochrome P450 cholesterol side-chain cleavage enzyme was unchanged. In conclusion, IGFs enhance the steroidogenesis and ACTH responsiveness of human adrenocortical cells in culture. We speculate, that by this mechanism, IGFs may contribute to clinical states with hyperandrogenemia. [less ▲]

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See detailRené Zazzo, poète et psychologue
Richelle, Marc ULg

in Enfance (1996), (2), 233-237

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See detailAntipeptide antibody against the bovine IGF-BP-2 : application to the detection of BST-treated cows
Scippo, Marie-Louise ULg; Degand, Guy ULg; Duyckaerts, Anne et al

in Food & Agricultural Immunology (1996), 8

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See detailRetizonomonoletes hunanensis Fang et al. 1993 and the Retispora lepidophyta morphon.
Steemans, Philippe ULg; Fang, Xiaosi; Streel, Maurice ULg

in Inst. Géol. de l'Univ. Louvain (1996), 36

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See detailWhere is the Algorithmic Support?
Wolper, Pierre ULg

in ACM Computing Surveys (1996), 28(4es), 58

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See detailLa gale psoroptique bovine. Une maladie éradicable ?
Mignon, Bernard ULg; Lonneux, J. F.; Losson, Bertrand ULg

in Sillon Belge (1996), 20.12.1996

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See detailActeurs sociaux et perspectives préventives du hooliganisme: Orientations en guise de conclusions
Kellens, Georges ULg; Comeron, Manuel ULg

in Revue Sport (1996), 1(153), 63-64

Euro 2000: sécurité, stewards, Fan coaching

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See detailOrdovician and Silurian cryptospores and miospores from southeastern Turkey
Steemans, Philippe ULg; Le Hérissé, A; Bozdogan, N

in Review of Palaeobotany and Palynology (1996), 93(1-4), 35-76

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See detailLes Deux Gredins et l'Ange énonciateur
Defays, Jean-Marc ULg

in Alice (des littératures de jeunesse) (1996), 1

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See detailcr de E. Wente, Letters from Ancient Egypt
Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1996), 71(141), 57-62

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See detailHomogeneous Lyapunov Functions and Necessary Conditions for Stabilization
Sepulchre, Rodolphe ULg; Aeyels, D.

in Journal of mathematics for control, signal and systems (1996), 9(1), 34-58

We provide necessary conditions for the stabilization of nonlinear control systems with the additional requirement that a time-invariant homogeneous Lyapunov function exists for the closed-loop system.

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See detailPhylogenetic Relationships of Nonaxenic Filamentous Cyanobacterial Strains Based on 16S rRNA Sequence Analysis
Nelissen, Bart; De Baere, Raymond; Wilmotte, Annick ULg et al

in Journal of Molecular Evolution (1996), 42

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish ... [more ▼]

In order to determine the nearly complete 16S rRNA gene sequences of cyanobacteria originating from nonaxenic cultures, a cyanobacterium-specific oligonucleotide probe was developed to distinguish polymerase chain reaction (PCR) products of the cyanobacterial rRNA operons from those resulting from amplification of contaminating bacteria. Using this screening method the 16S rRNA genes of four nonaxenic filamentous cyanobacterial strains belonging to the genera Leptolyngbya and OscitIatoria were cloned and sequenced. For the genus Leptolyngbya, the 16S rRNA sequence of the axenic strain PCC 73110 was also determined. Phylogenetic trees were constructed based on complete and partial sequences. The results show that the strains Leptolyngbya Jbveolarum Kom~rek 1964/112, Leptolyngbya sp. VRUC 135 Albertano t985/1, and LeptoIyngbya boryanum PCC 73110 belong to the same cluster. Strain Oscillatoria cf. corallinae SAG 8.92, which contains the rare photosynthetic pigment CUphycoerythrin, is not closely related to other CUphycoerythrin- containing cyanobacteria. Oscillatoria agardhii CYA 18, which is a representative of planktonic Oscillatoria species that form toxic blooms in Norwegian inland waters, has no close relatives in the tree. [less ▲]

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See detailDetection And Identification Of Sweet Potato Viruses By The Polymerase Chain Reaction
Colinet, D.; Lepoivre, Philippe ULg; Xia, Fz. et al

in Agro Food Industry Hi-Tech (1996), 7(2),

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See detailUse of the monofrequency forced oscillation technique to measure changes in upper airway resistance in Friesian and blue Belgian calves
Reinhold, Petra; Genicot, Bruno; Close, Roland et al

in Research in Veterinary Science (1996), 61(3), 227-230

Monofrequency forced oscillometry (MFO) using a sinusoidal test signal of one frequency (10 Hz) was compared with the classical pulmonary function technique (using an oesophageal balloon with airflow ... [more ▼]

Monofrequency forced oscillometry (MFO) using a sinusoidal test signal of one frequency (10 Hz) was compared with the classical pulmonary function technique (using an oesophageal balloon with airflow measurements) in two breeds of cattle which differ in their respiratory physiology, particularly to assess changes in upper airway resistance. Six healthy male Friesian calves (mean [SD] bodyweight 131 [12] kg) and six healthy male blue Belgian calves (mean [SD] bodyweight 137 [13] kg) were examined successively with their heads either in a normal position or held vertically, using a cross-over study design. In the normal position, higher resistances, a higher respiratory impedance, and lower values of the dynamic lung compliance (Cdyn) were measured in the blue Belgian than in the Friesian calves. In the vertical head position, total pulmonary resistance (RL) increased and Cdyn decreased significantly (P < 0.05). The changes in MFO-derived parameters were in accordance with the changes in classical parameters, and for both methods, the percentage changes were markedly higher in the blue Belgian calves. [less ▲]

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See detailLes tempêtes (tempêtes extratropicales, cyclones tropicaux et tornades)
Erpicum, Michel ULg; Van Hoof, Th.

in Le point sur le I de Géographie (Soc géogr de Liège) (1996), 4

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See detailRecently advanced computerized technology was applied to the investigation of morphometric, immunohistological and three-dimensional changes of the endometrial mucosa in order to evaluate quantitatively the effects of three doses of a new slow-release vaginal progesterone on the endometrium in post-menopausal women. A total of 20 menopausal women, deprived of ovarian function, were given oestrogen for 12 days and a combined therapy of oestrogen (administered orally) and progesterone for another 12 day period. Progesterone was administered vaginally through a new gel (Crinone) utilizing a bioadhesive, biocompatible polymer as a base to achieve a sustained release effect. An endometrial biopsy was taken before treatment, after oestrogen-only treatment and after the oestro-progestogen therapy. Before treatment, all the patients exhibited an atrophic endometrium. After oestrogen-only treatment, typical proliferative changes occurred: an increase in the endometrium thickness, an increase in the mitotic index, numerous cylinder-like glands and no coiled glands, and high concentrations of oestrogen receptors (ER) and progesterone receptors (PR). After the oestro-progestogen therapy, whatever the dose of progesterone given, a secretory transformation of the endometrial mucosa occurred, mitotic activity decreased significantly, more ramified and coiled glands were observed, and a decrease in PR content was noted in epithelial and stromal nuclei, and a decrease in PR content was also observed in epithelial nuclei but not in stromal nuclei. Accurate new techniques of image analysis have shown that crinone therapy could eliminate the proliferative effects of oestrogen treatment in post-menopausal women, despite doses as low as 45 mg of progesterone administered vaginally every other day. The results suggest that the sustained release effects of Crinone are clinically relevant.
Donnez, Jacques; NISOLLE, Michelle ULg; Casanas-Roux, Françoise et al

in Human Reproduction (1996), 11(1), 224-8

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the ... [more ▼]

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the rectovaginal septum endometriotic nodule to peritoneal endometriosis. Mitotic activity, stromal vascularization and the epithelium/stroma ratio were found to be significantly different in peritoneal and rectovaginal endometriosis. The evaluation revealed a major role of glandular epithelium in rectovaginal nodules where the stroma sometimes appeared absent around glandular epithelium. The study demonstrated opposite effects of gonadotrophin-releasing hormone agonists (GnRHa) and lynestrenol on the two lesions. Indeed, in peritoneal endometriosis, after GnRHa therapy, our study demonstrated a lower rate of mitosis and poor stromal vascularization. The same drug was unable to induce the same effects in the nodule although, in contrast, lynestrenol has a strong effect on nodule vascularization. In conclusion, it is suggested that the rectovaginal adenomyotic nodule is a specific disease, different from peritoneal endometriosis. It is not the consequence of 'deep infiltrating' endometriosis but can probably develop from Mullerian rests present in the rectovaginal septum. [less ▲]

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See detailRevascularisation rénale pour sauvetage ou préservation néphronique
VAN DAMME, Hendrik ULg; CREEMERS, Etienne ULg; Gillain et al

in Revue Médicale de Liège (1996), 51(2), 175-86

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse ... [more ▼]

La néphropathie ischémique est une entité de plus en plus fréquente, à cause du vieillissement de la population et du contrôle médicamenteux de l'hypertension. Une ischémie de l'ensemble de la masse rénale (sténoses serrées concernant les deux reins ou un rein unique) compromet la filtration glomérulaire et constitue une des rares formes d'insuffisance rénale chronique réversible. Actuellement, 30 à 50% des patients sélectionnés pour une revascularisation rénale ont une fonction rénale altérée. L'histoire naturelle des sténoses rénales (surtout les lésions athéroscléreuses) montre une évolutivité vers l'obstruction progressive avec perte de parenchyme fonctionnel. Une revascularisation rénale envisage soit la protection du capital néphronique (intervention prophylactique), soit un sauvetage néphronique (restauration ou stabilisation d'une fonction rénale déjà altérée). Les critères prédictifs de bénéfice à long terme sont analysés. Les rôles respectifs de l'angioplastie transluminale percutanée et de la chirurgie sont discutés. L'intérêt de la revascularisation rénale sur la fonction rénale a été apprécié chez 23 malades réno-vasculaires et azotémiques (créatinine > 20 mg/l) ainsi que chez 8 patients en oligoanurie d'origine ischémique. [less ▲]

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See detailFoot: Quels supporters pour l'an 2000
Stassen, Benjamin; Comeron, Manuel ULg

in Revue Sport (1996), 1(153), 72

Football et hooliganisme: panorama européen, aspect sécuritaire et judiciaire, acteurs sociaux et perspectives préventives, Euro 2000: sécurité, stewards, fan coaching

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See detailAntithrombin III in the therapy of severe sepsis
Lamy, Maurice ULg; Eisele, B.

in Biomedical Progress (1996), 9

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See detailRelationships between growth, cannibalism and survival rate in intensively cultured larvae and alevins of perch (Perca fluviatilis)
Mélard, Charles ULg; Baras, E.; Mary, L. et al

in Annales Zoologici Fennici (1996), 33

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See detailApproximation of reliability for multiple-trait animal models with missing data by canonical transformation
Gengler, Nicolas ULg; Misztal, I.

in Journal of Dairy Science (1996), 79(2), 317-328

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of ... [more ▼]

An algorithm for approximation of reliability for multiple traits by multiple diagonalization was modified to support missing data by weighting transformed contributions of records based on the pattern of missing data. The accuracy of approximation was assessed with simulated and field data by comparing approximate reliabilities with those from direct inversion. Simulated data had several levels of missing data and covariances between traits; correlations were close to those for linear type traits of dairy cattle. Field data were 1) dairy records for milk, fat, and protein yields with 26% of the observations for fat and protein removed and 2) beef records for birth weight, weaning weight, and mean gain after weaning with 43% of observations missing. These files also contained empty fixed effect classes. The algorithm worked best for simulated data, and, when covariances between traits decreased, proportion of missing traits decreased and the number of empty fixed classes decreased. For dairy data, improvement over single-trait reliability occurred only for traits with missing data; for beef data, little or no improvement occurred. The method is useful with multiple diagonalization if the proportion of missing records or number of empty fixed effect classes or covariances between traits is moderate. [less ▲]

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See detailDoes proliferation status predict radiation response in human tumors?
Coucke, Philippe ULg

in Radiotherapy & Oncology (1996), 40(Supp 1), 55

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See detailShedding of the 67-kD laminin receptor by human cancer cells.
Karpatova, M.; Tagliabue, E.; Castronovo, Vincenzo ULg et al

in Journal of Cellular Biochemistry (1996), 60(2), 226-34

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix ... [more ▼]

The 67-kD laminin receptor (67LR) is a cell membrane-associated molecule exhibiting high affinity for the basement membrane glycoprotein, laminin. While export of the 67LR toward the extracellular matrix has been recently suggested by electron microscopy studies, there is to date no evidence of shedding of the 67LR from cells. Using two monoclonal antibodies directed against the 67LR, we developed a double-determinant radioimmunoassay that demonstrates that the 67LR is released from cancer cells into the culture medium. The shed molecule exhibited the same apparent molecular weight as that of the membrane-associated 67LR, suggesting that no proteolytic cleavage is involved in the process. Furthermore, we demonstrate that the 67LR is not anchored to the membrane through a glycolsyl-phosphatidylinositol bridge. However, the observation that lactose increased the release of 67LR suggests that a lectin-type interaction is involved in the cell membrane association of this laminin binding protein and the cell surface. Interestingly, the released 67LR recovered after HPLC gel filtration was found free as well as associated to high molecular weight complexes. The free 67LR retained its ability to bind to the cell surface. Our study is the first demonstration that the 67LR is effectively shed by cancer cells. The released free 67LR could play an important role in modulating interactions between cancer cells and laminin during tumor invasion and metastasis. [less ▲]

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See detailBalancing the Cenozoic carbon and alkalinity cycles: Constraints from isotopic records
Godderis, Y.; François, Louis ULg

in Geophysical Research Letters (1996), 23(25), 3743-3746

A simple model of the carbon, alkalinity and strontium cycles is built up and used to interpret the carbon and strontium isotopic evolution of seawater over the Cenozoic as recorded in marine limestones ... [more ▼]

A simple model of the carbon, alkalinity and strontium cycles is built up and used to interpret the carbon and strontium isotopic evolution of seawater over the Cenozoic as recorded in marine limestones. The idea that weathering fluxes have increased globally over the Cenozoic in response to the Himalayan uplift is critically examined. It is shown that such an increase of global weathering, postulated to explain the sharp increase in the Sr-87/Sr-86 ratio, is not compatible with the carbon isotopic record, if the budgets of carbon, alkalinity and strontium are considered simultaneously. Another scenario of the Cenozoic evolution of global weathering consistent with the carbon isotopic record is proposed in which the global weathering flux varies only slightly over the Cenozoic with a small increase between 15 Ma and the present. This second scenario appears more consistent with the reconstructed carbonate sedimentation rate and the evolution of the carbon isotopic fractionation in continental and oceanic environments. [less ▲]

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See detailAn improved preparation method of benzyl and thenyl triphenylphosphonium salt
Zhang, Jian-Xin; Dubois, Philippe ULg; Jérôme, Robert ULg

in Synthetic Communications (1996), 26(16), 3091-3095

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine ... [more ▼]

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine can also be converted within high yields to phosphonium salts by removing the formed water by azeotropic distillation. Solvent (methylene chloride, chloroform and acetonitrile) and temperature have been chosen in close relation to the alcohol reactivity. Purification is straightforward and yields are relatively high. [less ▲]

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See detailElectrical microenvironment influence on the hydrolytic activity of free and immobilised Yarrowia lipolytica lipase
Paquot, Michel ULg; Deleu, Magali ULg; Beaufils, C. et al

in Biotechnology Letters (1996), 18(1), 73-78

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide ... [more ▼]

The role of electrical properties of interfaces upon the activity of free and immobilised Yarrowia lipolytica lipase has been investigated. Sodium taurocholate and Sedipur 400, an anionic polyacrylamide, enhance the negative character of the fatty droplets of substrate and tend to improve the lipolytic activity while the cationic polyacrylamide (Sedipur 900) has opposite effects. Ca+ which reduces the fatty droplets charge as Sedipur 900, is however a good activator of the enzyme. The role of electrical properties on the optimum pH of the immobilised enzyme is clearer. Immobilisation of the lipase on a positively charged support shifts its optimum pH to acidic pH by repulsion towards H+ ions around the support. [less ▲]

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See detailA Possible Role for the Alpha 1-->3 Galactosyl Epitope and the Natural Anti-Gal Antibody in Oncogenesis
Gollogly, L.; Castronovo, Vincenzo ULg

in Neoplasma (1996), 43(5), 285-9

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 ... [more ▼]

Glycoconjugates and their antibodies are vital components of host-tumor interaction. This review concentrates on the oncological implications of research concerning the alpha gal triad; the alpha 1-->3 galactosyl epitope (alpha Gal), the enzyme responsible for its construction, alpha 1,3 galactosyl transferase (alpha 1-3GT), and its associated antibody: anti-gal. Alpha gal epitopes, previously assumed to be absent from human tissue, have been demonstrated on several human cancer cell lines, senescent red blood cells, and Graves' disease thyrocytes. Alpha-gal presence on neoplastic lines is correlated with increased metastatic formation in animal models. The mechanisms of human response to these neoantigens are complex, as natural anti-gal antibodies exist in high titers in normal sera, thus predicting immunological recognition of cells expressing alpha gal epitopes. Hypotheses vary regarding the pathogenic contributions of metastasis-associated phenomena such as de novo expression of alpha gal and its unmasking by desialylation. The means by which alpha gal is sporadically expressed in human tissue remain unknown, as the galactosyl transferase which produces this epitope in constitutively expressive animals has undergone significant mutation at the genomic level in humans. Pathological re-expression is presumed to require permissive changes at a cellular level. Detailing these alterations is a prerequisite to the comprehension of the metastatic phenotype. In this context, the possibility of therapeutic strategies affecting alpha gal expression are also discussed. [less ▲]

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See detailMort mitotique ou mort apoptotique par irradiation : Même combat ?
Coucke, Philippe ULg; ZOUHAIR

in Médecine et Hygiène (1996), 54(2121), 1241-1245

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement ... [more ▼]

La mort cellulaire active (apoptose) est un phénomène ubiquitaire dans les organismes multicellulaires. L'apoptose joue un rôle essentiel dans la genèse d'un cancer et dans la réponse au traitement oncologique. Les radiations ionisantes sont capables d'induire une mort mitotique et une mort apoptotique. Nous définissons les caractéristiques radiobiologiques de chaque type de mort cellulaire et situons l'importance de l'apoptose pour la réponse tumorale aux radiations ionisantes. La modulation de ce «suicide cellulaire» devrait permettre une amélioration de l'index thérapeutique mais ceci implique une connaissance approfondie des mécanismes qui règlent l'apoptose [less ▲]

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See detailCaractéristiques paléontologiques des couches de transition Westphalien A/B dans le bassin de Campine (Sondage de Peer Kb206), Belgique.
Dusar, M.; Loboziak, S; Streel, Maurice ULg et al

in Sciences Géologiques. Bulletin (1996), 48

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See detailTests au sol du télescope spatial XMM
Mazy, Emmanuel ULg; Stockman, Yvan ULg; Rochus, Pierre ULg

in SupOptique Avenir 1996 page 14-16. (1996)

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See detailFibres alimentaires chez le chien : I. Définition et composition chimique
Diez, Marianne ULg; Istasse, Louis ULg

in Annales de Médecine Vétérinaire (1996), 140

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and ... [more ▼]

The present paper is the first part of a review on dietary fibres. Dietary fibres, frequently used in humans, are at present proposed to be incorporated in feed for pets. Definitions, types of fibres and the principal chemical constituents are described along with the potential applications in the agro-industry and therapy. [less ▲]

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See detailEvaluation du débit sanguin au niveau du quadriceps électrostimulé et contracté volontairement
Vanderthommen, Marc ULg; BAUVIR, Philippe ULg; Depresseux, J.C. et al

in Annales de Kinésithérapie (1996), 23(1), 20-23

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See detailcompte rendu de : T. Göransson, Albinus, Alcinous. Arius Didymus
Rochette, Bruno ULg

in Byzantion : Revue Internationale des Etudes Byzantines (1996)

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See detailUtilisation des antibiotiques dans la maladie de Crohn : de la théorie à la pratique
Louis, Edouard ULg; Drion, V.; Belaiche, Jacques ULg

in Médecine et Hygiène (1996), 54

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See detailAuguste à Eleusis. Un aspect méconnu de l'idéologiqe augustéenne
Rochette, Bruno ULg

in Cahiers de Clio (1996), 127(automne), 3-14

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See detailSeduzione borghese e cultura dell'artificio. Femmes fatales in Oriani e Chelli
Curreri, Luciano ULg

in Italian Quarterly (1996), 129-130

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See detailAge and correlation of the Barreinrinha Formation (Curua Group, Amazon Basin) : new evidence from the Miospore biostratigraphy
Loboziak, S.; Melo, J.H.G.; Rodriguez, R. et al

in Anais da Academia Brasileira de Ciencias (1996), 68(2), 207-212

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See detailLa santé face aux nouveaux mécanismes de production et de gestion des inégalités sociales
Gavray, Claire ULg

in Observatoire : Revue d'Action Sociale & Médico-Sociale (1996), 11-12

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See detailProduction of anti-PMSG antibodies and its relation to the productivity of rabbit does
Lebas, F.; Theau-Clement, M.; Remy, Benoît ULg et al

in World Rabbit Science (1996), 4(2), 57-62

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See detailLes traumatismes artériels thoraciques.
Sakalihasan, Natzi ULg; DEFRAIGNE, Jean ULg; Limet, Raymond ULg

in Vaisseaux, Coeur, Poumons (1996), 1(3), 97-101

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See detailInfection of cattle with Yersinia enterocolitica O:9 a cause of the false positive serological reactions in bovine brucellosis diagnostic tests.
Weynants, V.; Tibor, A.; Denoel, P. A. et al

in Veterinary Microbiology (1996), 48(1-2), 101-12

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of ... [more ▼]

During the last four years, an increasing number of cattle herds were classified positive by brucellosis screening tests in areas of Belgium and France free of the disease. No clinical symptom of brucellosis was reported in these animals and no Brucella abortus strains were isolated. After two years, no brucellosis outbreak was registered in all of the herds concerned. On this basis, all the serological reactions observed were classified as false positive. An ELISA using Yersinia Outer membrane Proteins (YOPs) as antigens was developed in order to discriminate between a Yersinia enterocolitica O:9 infection and a Brucella abortus infection. Antibodies against YOPs were detected in sera from Y. enterocolitica O:9 experimentally infected cattle (n = 4) but not in sera from B. abortus experimentally infected cattle (n = 4). In a field study, 66.7% of the 174 serum samples from cattle presenting false positive serological reactions showed anti-YOPs antibodies whereas only 10% of 454 sera, classified negative by the brucellosis screening tests, showed anti-YOPs antibodies. Our results suggest that infections with Y. enterocolitica O:9 may cause false positive reactions in brucellosis testing. [less ▲]

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See detailCytochemistry of the tergite epicuticle of Glomeris marginata (Villers) (MYRIAPODA, DIPLOPODA): preliminary experimental results
Compère, Philippe ULg; Defise, Stéphane; Goffinet, Gerhard ULg

in Mémoires du Muséum d'Histoire naturelle (Paris) - Acta Myriapodologica (1996), 169

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See detailReconnaissance of the general circulation of the North-Western European Continental Shelf by means of a three-dimensional turbulent closure model
Delhez, Eric ULg

in Earth-Science Reviews (1996), 41(1-2), 3-29

The general circulation of the North-Western European Continental Shelf is investigated by means of a three-dimensional macroscale mathematical model. Results corresponding to typical winter and summer ... [more ▼]

The general circulation of the North-Western European Continental Shelf is investigated by means of a three-dimensional macroscale mathematical model. Results corresponding to typical winter and summer conditions are described in detail. Prominent features are explained from a dynamic point of view by referring to the main forcing factors of the macroscale circulation on the North-Western European Continental Shelf: seasonal mean wind stress and atmospheric pressure, large a scale sea surface slope, non-linear interactions of the higher frequency processes and density differences. The role of the bottom topography is also highlighted. The largest seasonal variations are mainly due to the occurrence of a thermal stratification in summer over large parts of the shelf. In such conditions, there is only a weak interaction between the surface and bottom layers that have therefore significantly different dynamics. [less ▲]

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See detailAlteration of the endocrinological status of growing calves by a glucocorticoid treatment.
Massart, Serge; Bertozzi, Carlo; Prandi, A. et al

in Journal of Animal Science (1996), 74(1), 230

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See detailEx-vivo cytokine production by whole blood cells from cancer patients
De Groote, Donat; Vrindts-Gevaert, Yvonne; Lopez Y Cadenas, Miguel ULg et al

in Cancer Detection & Prevention (1996), 20

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See detailPost-Migration Ethnicity - G. Baumann and T. Sunier
Martiniello, Marco ULg

in New Community (1996), 22(4), 716-717

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See detailL'endotoxémie dans l'espèce équine. 1ère partie: étiologie et physiopathologie.
Amory, Hélène ULg

in Pratique Vétérinaire Equine (1996), 28

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See detailBetween Peasant and Urban Villagers - M.J. Eula
Martiniello, Marco ULg

in Ethnic and Racial Studies (1996), 19(3), 757-759

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See detailNucleic acid detection by in situ molecular immunogold labeling procedures.
Thiry, Marc ULg

in Scanning Microscopy. Supplement (1996), 10

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new ... [more ▼]

We have recently combined immunogold labeling procedures with molecular biology methods to pinpoint the precise locations of nucleic acids in biological material at the ultrastructural level. These new immunocytological approaches involve the incorporation of labeled nucleotides in the nucleic acids present at the surface of ultrathin sections prior to immunogold labeling. The antibodies used recognize a nucleoside analogue (bromodeoxyuridine) or a hapten (biotin) employed to label nucleotides. Examples of high-resolution detection include DNA or RNA present in different substructures of cell nuclei, and in particular, in adenovirus-induced intranuclear regions of HeLa cells. In addition to being highly sensitive and specific, these new methods offer the possibility of studying the spatial distribution of nucleic acids in very well preserved, readily recognizable structures. [less ▲]

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See detailTrends of OCS, HCN, SF6, CHClF2, (HCFC-22) in the lower stratosphere from 1985 and 1994 atmospheric trace molecule spectroscopy experiment measurements near 30 degrees N latitude
Rinsland, C. P.; Mahieu, Emmanuel ULg; Zander, Rodolphe ULg et al

in Geophysical Research Letters (1996), 23(17), 2349-2352

Volume mixing ratio (VMR) profiles of OCS, HCN, SF6, and CHClF2 (HCFC-22) have been measured near 30 degrees N latitude by the Atmospheric Trace Molecule Spectroscopy Fourier transform spectrometer during ... [more ▼]

Volume mixing ratio (VMR) profiles of OCS, HCN, SF6, and CHClF2 (HCFC-22) have been measured near 30 degrees N latitude by the Atmospheric Trace Molecule Spectroscopy Fourier transform spectrometer during shuttle flights on 29 April-6 May 1985 and 3-2 November 1994. The change in the concentration of each molecule in the lower stratosphere has been derived for this 9 1/2-year period by comparing measurements between potential temperatures of 395 to 800 K (similar to 17 to 30 km altitude) relative to simultaneously measured values of the long-lived tracer N2O. Exponential rates of increase inferred for 1985-to-1994 from these comparisons are (0.1 +/- 0.4)% yr(-1) for OCS, (1.0 +/- 1.0)% yr(-1) for HCN, (8.0+/-0.7)% yr(-1) for SF6, and (8.0 +/- 1.0)% yr(-1) for CHClF2 (HCFC-22), 1 sigma. The lack of an appreciable trend for OCS suggests the background (i.e., nonvolcanic) source of stratospheric aerosol was the same during the two periods. These results are compared with trends reported in the literature. [less ▲]

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See detailLivestock Genomics Comes of Age
Georges, Michel ULg; Andersson, L.

in Genome Research (1996), 6(10), 907-21

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See detailQuel encadrement pour quelle qualité de l'enseignement?
Lafontaine, Dominique ULg

in Pilotinfo (1996), (13), 1-8

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See detailLes Charites à Athènes et dans l’île de Cos
Pirenne-Delforge, Vinciane ULg

in Kernos : Revue Internationale et Pluridisciplinaire de Religion Grecque (1996), 9

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See detailCloning of choriocarcinoma cells shows that invasion correlates with expression and activation of gelatinase A
Crescimanno, C.; Foidart, Jean-Michel ULg; Noël, Agnès ULg et al

in Experimental Cell Research (1996), 227

Implantation and placental development are dependent upon trophoblast invasion of the endometrium. While the villous trophoblast does not display invasive behavior, the extravillous cytotrophoblast is ... [more ▼]

Implantation and placental development are dependent upon trophoblast invasion of the endometrium. While the villous trophoblast does not display invasive behavior, the extravillous cytotrophoblast is highly invasive. By cloning BeWo choriocarcinoma cells, we have isolated two distinct clones that share similarities with villous and extravillous cytotrophoblasts. When cultured at the surface of a type I collagen gel, BeWo MC-1 cells were not invasive, whereas BeWo MC-2 cells rapidly invaded this matrix. When injected subcutaneously in nude mice, BeWo MC-1 cells developed a localized tumor and BeWo MC-2 cells developed larger tumors with micrometastases. Gelatinase A expression and minute amounts of gelatinase B were detected in the parental cell line and in both clones. However, the parental and the BeWo MC-2 cells secreted 5- to 10-fold more gelatinase A than the BeWo MC-1 cells. Laminin and matrigel stimulated the production of gelatinase A in BeWo MC-2 cells. Type I collagen promoted the conversion of the 72-kDa progelatinase A in an active enzyme only in parental BeWo and in BeWo MC-2 cells. These clones provide an interesting model for studying the complex mechanisms regulating implantation as well as the controlled invasiveness during implantation compared to tumor invasion. [less ▲]

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See detailA site with foliicolous lichens in Belgium
van den Boom, Pieter; Sérusiaux, Emmanuël ULg

in Belgian Journal of Botany (1996), 129

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See detailLanguage in adults with Down syndrome
Rondal, Jean-Adolphe ULg; Comblain, Annick ULg

in Down's Syndrome, Research and Practice : The Journal of the Sarah Duffen Centre (1996), 4(1), 3-14

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language ... [more ▼]

In this paper, we will try to supply at least a partial answer to the three following questions. First, what language levels are reached by adults with Down syndrome? Second, is there progress in language or some aspects of it beyond adolescence and during the adult years? This question is related to the issue of a critical period for language development raised by Eric Lenneberg (1967). Third, what is the effect of ageing on the language of persons with Down syndrome, including those who develop Alzheimer disease in old age? [less ▲]

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See detailThe Meaning of ``Formal''
Wolper, Pierre ULg

in ACM Computing Surveys (1996), 28(4es), 127

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See detailCompte rendu de l'ouvrage de ANDORLINI Isabella (Edizione e commento a cura di), Trattato di medicina su papiro, Firenze, Istituto Papirologico "G. Vitelli", 1995
Marganne, Marie-Hélène ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1996), 71

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See detailA numerical investigation in the transition zone of the NW African upwelling
Elmoussaoui, A.; Djenidi, Salim ULg; Kostianoy, A. et al

in Bulletin de la Société Royale de Liège (1996), 65

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See detailAssessment of the cell-mediated immunity in cattle infection after bovine herpesvirus 4 infection, using an in vitro antigen-specific interferon-gamma assay.
Godfroid, J.; Czaplicki, G.; Kerkhofs, P. et al

in Veterinary Microbiology (1996), 53(1-2), 133-41

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has ... [more ▼]

The cell-mediated immunity (CMI) following bovine herpesvirus 4 (BHV4) infection has been poorly investigated in cattle. The in vivo response measured by a delayed type of hypersensitivity (DTH) assay has been reported to be positive in only few animals showing serological evidences of BHV4 infection. We have investigated the CMI following BHV4 infection by an in vitro antigen-specific interferon gamma (IFN-gamma) release assay, as an indicator of an actively acquired immunity to BHV4. Our preliminary results using a partially purified antigen suggest that there was a measurable CMI in 75 out of 168 animals (44.4%) originating from a farm with a clinical history and serological evidences (76.3% seropositivity) of BHV4 infection. If the results of serological tests and BHV4 IFN-gamma test are interpreted in parallel, 81.5% of the animals are classified positive, demonstrating the complementarity of these tests. The specificity of the BHV4 IFN-gamma test was supported by the absence of a measurable CMI in 41 animals originating from a farm with no clinical history or serological evidence of BHV4 infection. In an allied study, we developed a bovine herpesvirus 1 (BHV1) IFN-gamma test. This allowed us to measure the antigen specific IFN-gamma release after stimulation with a mixture of BHV1 and BHV4 antigens. Animals that were classified negative by the BHV4 IFN-gamma test and by the BHV1 IFN-gamma test, were classified negative after stimulation with a mixture of both antigens. Animals that were classified positive by the BHV4 IFN-gamma test or the BHV1 IFN-gamma test, were classified positive after stimulation with a mixture of both antigens. Taken together these results suggest that the in vitro assessment of the CMI after BHV4 infection should be further investigated as a specific and valuable alternative to the DTH assay. [less ▲]

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See detailModulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen
Willardgallo, Ke.; Delmellewibaut, C.; Segurazapata, I. et al

in Aids Research and Human Retroviruses (1996), 12(8),

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See detailArthrite septique du boulet : corrélation entre imagerie et examen anatomo-pathologique
Busoni, Valeria ULg; Rossi, Giacomo; Denoix, Jean-Marie

in Pratique Vétérinaire Equine (1996), 28

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See detailBactericidal activity against Pseudomonas aeruginosa is acquired by cultured human monocyte-derived macrophages after uptake of myeloperoxidase.
Mathy-Hartert, M.; Deby, Ginette ULg; Melin, Pierrette ULg et al

in Experientia (1996), 52(2), 167-74

Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules ... [more ▼]

Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules. Pseudomonas aeruginosa (10(6) bacteria per 1ml) are killed within 1 h in vitro by a MPO/H2O2/C1- system (48mU=132ng of MPO). The question arose as to whether human macrophages would acquire cytotoxic activity when loaded with this enzyme. Monocytes were therefore isolated from human blood and cultured for up to ten days to induce maturation to macrophages. These cells lost endogenous MPO within five days while H2O2 production in response to stimulation by phorbol myristate acetate (10(-6)M) decreased to 23% within ten days. On the other hand, their capacity to take up exogenous MPO increased fourfold from day three to day ten. Human macrophages cultured from eight days (when both H2O2 production and MPO uptake were sufficient) were therefore used to study the effects of MPO uptake on cytocidal activity against Pseudomonas aeruginosa. After a 1 h MPO loading period, macrophages (5X10(5) cells per ml) were incubated in the presence of bacteria (0.5 to 2X10(6) bacteria per ml) for 2 h at 37 degrees C. At a bacteria/macrophage ratio of 1, only 34.8+/-7.0% of bacteria survived (compared to killing by non-loaded macrophages), while 74.4+/-9.3% survived at a ratio of 4. From these results, we conclude that loading macrophages with exogenous MPO could enhance their microbicidal activity, suggesting a potentially useful therapeutic application. [less ▲]

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See detailThe tilapia prolactin I gene: evolutionary conservation of the regulatory elements directing pituitary-specific expression
Poncelet, A. C.; Levavi-Sivan, B.; Muller, Marc ULg et al

in DNA & Cell Biology (1996), 15(8), 679-92

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately ... [more ▼]

To study the elements involved in the pituitary specific transcriptional regulation of the tilapia prolactin I gene (tiPRL I), we have cloned and entirely sequenced a 3.4-kb genomic fragment immediately upstream from the first exon. In footprinting experiments, three tilapia sequences are protected from DNase I digestion by rat pituitary extracts (base pair coordinates -643 to -593, -160 to -111, and -73 to -46). Computer analysis of the nucleotide sequence reveals significant homology to mammalian binding sites for Pit-1, a transcription factor that is known to mediate pituitary-specific expression of the PRL genes in mammals. The tiPRL I 5'-flanking sequences can direct transient expression of a linked luciferase reporter gene in transfected rat pituitary cell lines and tilapia pituitary primary cell cultures. Transient expression experiments with 5'-deletion mutants reveal three regulatory regions. Two have a stimulatory effect on transcription and one an inhibitory effect. Electrophoretic mobility-shift assays (EMSA) demonstrate that the rat Pit-1 factor specifically binds to tilapia DNA sequences. Several such tilapia Pit-1 binding sites mediate activation of a linked heterologous promoter in transfected rat and tilapia pituitary cells. As evidenced by EMSA, a Pit-1-like protein is present in tilapia pituitary extracts. All these data point to a high conservation of the molecular mechanisms involved in pituitary-specific expression of the PRL genes in vertebrates. [less ▲]

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