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See detailEvaluation of some parameters influencing the drug delivery from a dry powder inhalation device using an in vitro model of the horse airways
Duvivier, Dominique Hannia; Chiap, Patrice ULg; Crommen, Jacques ULg et al

in Veterinary Research (1997), 28(6), 557-564

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M ... [more ▼]

The aim of this study was to determine the effect of breathing pattern, air humidity and position of the device on the delivery of an aerosol generated by a dry powder inhalation (DPI) device (Inhalator M). The in vitro inhalation study was performed using the cascade impaction method (Andersen Sampler) adapted to imitate nasal breathing. The amount of ipratropium found in the device, the artificial upper airways and the six stages of the Andersen Sampler was measured using high precision liquid chromatography. Stage 1 of the Andersen Sampler was considered to be the respirable fraction and stages 2 to 6 to be the non-respirable fraction. It was concluded that the theoretical respirable fraction of ipratropium obtained after DPI through Inhalator M was influenced by relative air humidity, air flow and the position of the device, whereas the number of successive inspirations and the duration of inspiration did not affect this fraction of the drug. [less ▲]

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See detailAerogel compression theoretical analysis
Pirard, René ULg; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (1997), 212(2-3), 262-267

Several authors have empirically shown that, in aerogels, a power law exists between the mechanical moduli and the bulk density. An exponent value can be determined from mercury porosimetry curves. The ... [more ▼]

Several authors have empirically shown that, in aerogels, a power law exists between the mechanical moduli and the bulk density. An exponent value can be determined from mercury porosimetry curves. The shrinkage of aerogels under mercury pressure follows a buckling mechanism which links the pore size to the exerted pressure. The present study relates the exponent to the pore volume distribution which can be described by a hierarchical model valid in a large range of pore size, so a physical meaning is given to the exponent. [less ▲]

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See detailCompactly supported wavelets in Sobolev spaces of integer order
Bastin, Françoise ULg; Laubin, P.

in Applied & Computational Harmonic Analysis (1997), 4(1), 51-57

We present a construction of regular compactly supported wavelets in any Sobolev space of integer order. It is based on the existence and suitable estimates of filters defined from polynomial equations ... [more ▼]

We present a construction of regular compactly supported wavelets in any Sobolev space of integer order. It is based on the existence and suitable estimates of filters defined from polynomial equations. We give an implicit study of these filters and use the results obtained to construct scaling functions leading to multiresolution analysis and wavelets. Their regularity increases linearly with the length of their supports as in the L(2) case. One technical problem is to prove that the intersection of the scaling spaces is reduced to 0. This is solved using sharp estimates of Littlewood-Paley type. (C) 1997 Academic Press, Inc. [less ▲]

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See detailLa violence dans les stades de football
Comeron, Manuel ULg

in Revue Générale (1997), (2), 21-30

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See detailDissociations between the processing of proper and common names
Brédart, Serge ULg; Brennen, T.; Valentine, T.

in Cognitive Neuropsychology (1997), 14(2), 209-217

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See detailA cinnabar local order in liquid II-VI compounds
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Ceolin, R. et al

in Physica B: Condensed Matter (1997)

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure ... [more ▼]

A short wavelength (lambda=0.7 Aring) neutron scattering experiment has been performed on the II-VI compounds HgS, HgSe and Zn xHg 1-xTe. Liquid HgS can be viewed as a distortion of the blende structure; we show that this distortion decreases gradually with temperature. For Zn xHg 1-xTe, we show that the transition between the six coordinated HgTe liquid and the four coordinated ZnTe liquid is not continuous, the intermediate phase being a deformed cinnabar one [less ▲]

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See detailFoaming properties of a natural cyclic lipoheptapeptide belonging to a special class of amphiphilic molecules
Razafindralambo, Hary ULg; Paquot, Michel ULg; Baniel, A. et al

in Food Hydrocolloids (1997), 11(1), 59-62

The foaming properties of surfactin, a natural cyclic lipoheptapeptide from Bacillus subtilis, were investigated in comparison and in association with those of bovine serum albumin (BSA). An apparatus ... [more ▼]

The foaming properties of surfactin, a natural cyclic lipoheptapeptide from Bacillus subtilis, were investigated in comparison and in association with those of bovine serum albumin (BSA). An apparatus combining bubbling, optical and conductimetric methods was used to study continuously foam formation and stability in terms of the quantity and density of foam. The increase in surfactin concentration from 0.05 to 0.2 mg/ml had little effect on its foaming capacity, measured by the bubbling time to produce the required foam volume, but improved the foam maximum density significantly. Surfactin produced foam with higher maximum density and stability, and forms more regular and smaller bubbles than BSA. In addition, a synergistic effect was observed on the stability of liquid in foam prepared with a mixture of 50:50 surfactin/BSA. The liquid half-life of BSA foam was enhanced up to 40% when surfactin was added to the solution. [less ▲]

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See detailEffects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies.
Mouithys-Mickalad, Ange ULg; Deby, Ginette ULg; Hoebeke, Maryse ULg et al

in Mediators of Inflammation (1997), 6(5-6), 327-33

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of ... [more ▼]

Sphingolipids inhibit the activation of the neutrophil (PMN) NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR) and chemiluminescence (CL), we studied the effects of sphingosine (SPN) and ceramide analogues on phorbol 12-myristate 13-acetate (PMA, 5 x 10(-7)M) stimulated PMN (6 x 10(6) cells). By ESR with spin trapping (100 mM DMPO: 5,5-dimethyl-1-pyrroline-Noxide), we showed that SPN (5 to 8 x 10(-6)M), C(2)-ceramide (N-acetyl SPN) and C(6)-ceramide (N-hexanoyl SPN) at the final concentration of 2 x 10(-5) and 2 x 10(-4)M inhibit the production of free radicals by stimulated PMN. The ESR spectrum of stimulated PMN was that of DMPO-superoxide anion spin adduct. Inhibition by 5 x 10(-6)M SPN was equivalent to that of 30 U/ml SOD. SPN (5 to 8 x 10(-6)M) has no effect on in vitro systems generating superoxide anion (xanthine 50 mM/xanthine oxidase 110 mU/ml) or hydroxyl radical (Fenton reaction: 88 mM H(2)O(2), 0.01 mM Fe(2+) and 0.01 mM EDTA). SPN and N-acetyl SPN also inhibited the CL of PMA stimulated PMN in a dose dependent manner (from 2 x 10(-6) to 10(-5)M), but N-hexanoyl SPN was less active (from 2 x 10(-5) to 2 x 10(-4)M). These effects were compared with those of known PMN inhibitors, superoxide dismutase, catalase and azide. SPN was a better inhibitor compared with these agents. The complete inhibition by SPN of ESR signal and CL of stimulated PMN confirms that this compound or one of its metabolites act at the level of NADPH-oxidase, the key enzyme responsible for production of oxygen-derived free radicals. [less ▲]

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See detailComment j'explore ... Une maladie de Basedow: de la clinique classique au diagnostic radio-immunologique.
Scheen, André ULg

in Revue Médicale de Liège (1997), 52(12), 788-91

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See detailLa maladie de Buerger: aspects cliniques et pronostiques
VAN DAMME, Hendrik ULg; Deprez, E.; DEFRAIGNE, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 675-82

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See detailDetermination of radiative lifetimes of neutral sulphur by time-resolved three-photon VUV laser spectroscopy
Berzinsh, U.; Caiyan, L.; Zerne, R. et al

in Physical Review. A : General Physics (1997), 55

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See detailIn vivo behavior of poly(D,L)-lactide microspheres designed for chemoembolization
Flandroy, P.; Grandfils, Christian ULg; Danen, B. et al

in Journal of Controlled Release (1997), 44(2-3), 153-170

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is ... [more ▼]

Although chemoembolization advantageously combines arterial embolization of the vascular supply of a neoplasm with controlled intra-arterial infusion of chemotherapeutic drug(s), its application is limited by the lack of appropriate and reliable embolization materials. Recently, calibrated microspheres of poly(D,L)-lactide have proved to be promising in embolization. Nevertheless, repetitive chemoembolization requires the availability of microspheres degradable within a few days. For this purpose, microspheres consisting of a blend of two polyesters of a very different molecular weight (Mn =65 000 and 3500 in a 16:84 wt. ratio) have been prepared and injected in the renal arteries of rabbits. The in vivo fate of these two component microspheres has been compared by radiology and histology to microspheres prepared from the high molecular weight poly(D,L)-lactide. Furthermore, the in vivo degradation of the polymer has been measured by size exclusion chromatography after quantitative reextraction from the embolized kidney. Degradation kinetics has been compared to data previously reported in vitro. According to the observations performed during the in vivo study, the 50/50 microspheres appear more useful for the chemoembolization of tumors. [less ▲]

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See detailEnergy savings in methanol synthesis: Use of heat integration techniques and simulation tools.
Maréchal, François; Heyen, Georges ULg; Kalitventzeff, Boris ULg

in Computers & Chemical Engineering (1997), 21(Suppl. S), 511-516

Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and ... [more ▼]

Starting with a classical process for producing methanol using the reforming and synthesis steps, a combined approach applying simulation models and a new synthesis strategy, named Effect Modelling and Optimisation (EMO), has been used to optimise the energy efficiency of the process. The method allows to identify different ways of improving the energy efficiency of the process. The modifications concern the synthesis reactor and the reforming reactor designs, the exploitation of the purge stream as fuel gas to satisfy the process requirement and its integration to a gas turbine system. The EMO approach allows to target the impact of a process modification at the global level of the energy cost of the process, including the combined production of heat and mechanical power in a gas turbine and the steam network. Starting with a classical methane conversion of 60% for the classical system, we identify solutions with up to 93% of the overall methane conversion when we transform the net mechanical power produced into methane savings at the country level. The interest of the approach is the possibility of computing the impact of the process modifications suggested by the analysis of the shape of the heat cascade on the overall energy balance of the plant without having to simulate in many details the steam and the heat exchanger network. [less ▲]

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See detailLe maintien des droits aux prestations de santé lors d'une séparation de fait ou de corps
Michiels, Olivier ULg

in Divorce : Actualité Juridique, Sociale et Fiscale (1997)

L'article examine la question du maintien des droits aux prestations de santé lors d'une séparation de corps ou d'une séparation de fait.

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See detailDilatometric and calorimetric study of the graphitisation of high chromium cast iron
Terziev, L.; Lecomte-Beckers, Jacqueline ULg; Bojinov, V. et al

in Journal de Chimie Physique et de Physico-Chimie Biologique (1997), 94[5]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements ... [more ▼]

Cette étude est consacrée à la formation du graphite dans des fontes à haute teneur en chrome (8%) et spécialement à la détermination des conditions de formation de graphite secondaire par des traitements thermiques adaptés. La solidification de la fonte étudiée a été examinée par analyse thermique différentielle (ATD). Les effets d'un traitement à haute température ont été examinés à la fois par calorimétrie et dilatomètre différentielle. Le graphite primaire se forme vers 950°C. Le graphite secondaire précipite sur le graphite primaire lors du traitement de déstabilisation de l'austénite à haute température. La forme et la quantité de graphite secondaire dépendent de la température de traitement. [less ▲]

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See detailInvolvement of different transduction pathways in NF-kappaB activation by several inducers
Legrand-Poels, Sylvie ULg; Zecchinon, Laurent; Piret, Bernard et al

in Free Radical Research (1997)

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See detailIntroduction à l'analyse des données par le logiciel Minitab sous Windows
Claustriaux, Jean-Jacques ULg

in Notes de Statistique et d'Informatique (1997), (2), 1-22

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See detailA Direct Dopaminergic Control of Aromatase Activity in the Quail Preoptic Area
Baillien, M.; Balthazart, Jacques ULg

in Journal of Steroid Biochemistry & Molecular Biology (1997), 63(1-3, Sep-Oct), 99-113

In the quail preoptic area (POA) anatomical and pharmacological data suggest that catecholamines may be implicated in the control of testosterone (T) aromatization into estrogens. The biochemical ... [more ▼]

In the quail preoptic area (POA) anatomical and pharmacological data suggest that catecholamines may be implicated in the control of testosterone (T) aromatization into estrogens. The biochemical mechanism(s) mediating this control of the enzyme activity is (are) however unexplored. The present studies were carried out to investigate whether the catecholamines, dopamine (DA) and norepinephrine (NE) are able to directly affect aromatase activity (AA) measured during in vitro incubations of POA homogenates. AA was quantified in the POA-hypothalamus of adult male Japanese quail by measuring the tritiated water production from [1beta-3H]-androstenedione. Enzyme activity was linear as a function of the incubation time and of the protein content of homogenates. It exhibited a typical Michaelis-Menten kinetics, with an apparent Km of 2.8 nM and a Vmax of 266.6 fmol h(-1) mg wet weight(-1). AA was then measured at a substrate concentration of 25 nM in the presence of catecholamines and some of their receptor agonists or antagonists, at two concentrations, 10(-3) and 10(-6) M. Norepinephrine and prazosin (alpha1-adrenergic antagonist) had no or very limited effects on AA at both concentrations. In contrast, DA and some D1 and/or D2 receptor agonists (apomorphine[D1/D2], SKF-38393 [D1] and RU-24213 [D2]) depressed AA by 40 to 70% at the 10(-3) M concentration. One D2 receptor antagonist also produced a major inhibition of AA (sulpiride) while other antagonists either had no significant effect or only produced moderate decreases in enzyme activity (SCH-23390 [D1], spiperone [D2], pimozide [D2]) as did two DA indirect agonists, amfonelic acid and nomifensine. The inhibitory effect of the agonists was not antagonized by the less active antagonists, SCH-23390 [D1] or spiperone [D2]. Taken together these results suggest that the inhibitory effects do not involve specific binding of DA or its agonists/antagonists to dopaminergic receptors mediating changes in cAMP concentration. This conclusion is also supported by the observation that addition of dibutyryl cAMP did not change brain AA. It appears more likely that DA and dopaminergic drugs inhibit AA by a direct effect on the enzyme, as suggested by the competitive nature of DA and SKF-38393 inhibition of AA (Ki's of 59 and 84 microM, respectively). The functional significance of this effect should still be demonstrated but this mechanism may represent an important physiological pathway through which neurotransmitters could rapidly affect steroid-dependent processes such as the neural synthesis of estrogens. This would provide a mean by which environmental stimuli could affect reproductive behavior and physiology. [less ▲]

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See detailOptimizing the treatment of Paget’s disease of bone
Reginster, Jean-Yves ULg; Gennari, C; Hosking, DJ et al

in Revue du Rhumatisme (English ed.) (1997), 64(4), 207-209

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See detailAspects économiques du financement des communes
Jurion, Bernard ULg

in Revue de Droit Communal (1997)

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See detailThe He(I), Threshold photoelectron and Constant Ion State spectroscopy of Vinylchloride (C2H3Cl).
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been ... [more ▼]

Using synchrotron radiation the threshold photoelectron (TPES) spectrum and constant ion state (CIS) spectroscopy of C2H3Cl are reported. For comparison, the He(I) photoelectron spectrum has also been measured and reexamined. The threshold photoelectron spectrum has been measured between 9.0 and 25.0 eV and the photon energy range of 9.9-12.0 eV has been investigated in detail. Many features have been identified and tentatively assigned with the help of the photoabsorption spectroscopic results. These data were compared with the well-resolved He(I) photoelectron spectrum. The fine structure observed in the two first ionic states is assigned to progressions belonging partially to previously unobserved vibration normal modes. State-selected CIS spectra have been recorded for the first vibronic states between 10.0 and 11.67 eV. They exhibit fine structure assigned to autoionization of Rydberg states. [less ▲]

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See detailFungal contamination in barley and Kashin-Beck disease in Tibet
Chasseur, Camille; Suetens, Carl; Nolard, Nicole et al

in Lancet (1997), 350

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See detailIntellectuels malgré eux
Denis, Benoît ULg

in Réseaux : Revue Interdisciplinaire de Philosophie Morale et Politique (1997), (79-81), 49-52

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See detailPower system security assessment: a position paper
Marceau, R.J.; Endrenyi, J.; Allan, R. et al

in Electra (1997), 175

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See detailFast and slow tracks in lysozyme folding: Insight into the role of domains in the folding process
Matagne, André ULg; Radford, S. E.; Dobson, C. M.

in Journal of Molecular Biology (1997), 267(5), 1068-1074

The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates. We have monitored directly the kinetics of ... [more ▼]

The folding of lysozyme involves parallel events in which hydrogen exchange kinetics indicate the development of persistent structure at very different rates. We have monitored directly the kinetics of formation of the native molecule by the binding of a fluorescently labelled inhibitor, MeU-diNAG (4-methylumbelliferyl-N,N'-diacetyl-beta-D-chitobioside). The data show that native character monitored in this way also develops with different timescales. Although the rate determining step on the slow pathway (similar to 75% of molecules at pH 5.5, 20 degrees C) can be attributed to the need to reorganise structure formed early in the folding process, the data indicate that the rate determining step on the fast track (involving similar to 25% of molecules) involves the docking of the two constituent domains of the protein. In the fast folding track the data are consistent with a model in which each domain forms persistent structure prier to their docking in a locally cooperative manner on a timescale comparable to the folding of small single domain proteins. (C) 1997 Academic Press Limited. [less ▲]

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See detailComparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood.
Sautois, Brieuc ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Experimental hematology (1997), 25(2), 103-8

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host ... [more ▼]

Cord blood transplantations successfully reconstituted hemopoiesis in patients treated with myeloablative therapies. These transplantations were associated with a low rate of acute graft-versus-host disease (aGVHD), a major life-threatening complication of allo-transplantation. The physiopathology of aGVHD implies the recognition of host alloantigens by donor T cells but also involves a cytokine cascade. In this cascade, interleukin (IL)-1, IL-2, IL-6, tumor necrosis factor alpha (TNF-alpha), and interferon gamma (IFN-gamma) produced by donor T cells and monocytes/macrophages play a major effector role. Therefore, we investigated whether the lower percentage of aGVHD in cord blood transplants could be related to a lower ability to produce these cytokines in vitro compared with adult blood. Mononucleated cells (MNCs) isolated from term cord blood and adult peripheral blood were stimulated with a combination of lipopolysaccharide and phytohemaglutinin and incubated for 96 hours. Levels of IL-1beta, IL-2, IL-3, IL-4, IL-6, TNF-alpha, IFN-gamma, and granulocyte-macrophage colony-stimulating factor (GM-CSF) were measured in the supernatants after various times of incubation. The productions of IL-1beta, IL-6, and GM-CSF were similar in stimulated cord and adult blood and IL-3 levels, though lower and delayed in cord blood, were not statistically different. On the other hand, we found markedly lower levels of IFN-gamma, TNF-alpha, and IL-4 in cord blood throughout the incubation period. The stimulated levels of IL-2 were similar in cord and adult samples throughout the first 48 hours of incubation but became significantly lower in cord blood after 72 and 96 hours. We suggest that the cytokine production pattern that characterizes cord blood could provide an explanation for the lower occurence of aGVHD following cord blood transplants. [less ▲]

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See detailBounds on the Soft Pomeron Intercept
Cudell, Jean-René ULg; Kang, Kyungsik; Kim, Sung Ku

in Physics Letters B (1997), 395

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See detailThe Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Research Communications (1997), 21(7), 521-531

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet ... [more ▼]

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. [less ▲]

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See detailIntegrator forwarding : a new recursive nonlinear robust design
Sepulchre, Rodolphe ULg; Jankovic, M.; Kokotovic, Petar V.

in Automatica (1997), 33(5), 979-984

We consider the global stabilization of nonlinear systems in strict feedforward form. We show that these systems, while not feedback linearizable, can be (globally) transformed by feedback and ... [more ▼]

We consider the global stabilization of nonlinear systems in strict feedforward form. We show that these systems, while not feedback linearizable, can be (globally) transformed by feedback and diffeomorphism into a lower-triangular form. The transformation is explicit and recursive. We employ this transformation to design a globally stabilizing controller with optimality properties and an input-to-state stability property with respect to matched uncertainties. [less ▲]

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See detailLa nouvelle réglementation du concordat judiciaire
Thirion, Nicolas ULg

in Actualités du Droit (1997), (3), 379-420

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See detailA two-dimensional Navier-Stokes inverse solver for compressor and turbine blade design
Demeulenaere, A.; Léonard, Olivier ULg; Van den Braembussche, René

in Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy (1997), 211(4), 299-307

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on ... [more ▼]

A two-dimensional viscous inverse method for the design of compressor and turbine blades is presented. It iteratively modifies an initial geometry until a prescribed pressure distribution is reached on the blade surface. The method solves the time-dependent Navier-Stokes equations in a numerical domain of which some boundaries (the blade walls) move during the transient part of the computation. The geometry modification algorithm is based on the transpiration principle: a normal velocity distribution is computed from the difference between the actual and prescribed pressure distributions, and is used to modify the blade shape. A time iteration is then performed on this new blade shape, taking into account the grid movement during the time stepping. A two-dimensional upwind finite-volume Navier-Stokes solver has been developed. The multiblock strategy allows for a selective concentration of the discretization points in the zones of higher gradients. Applications to turbine and compressor blade design illustrate the accuracy of the flow computation, the capabilities and efficiency of the inverse method. [less ▲]

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See detailPrevention and treatment of postmenopausal osteoporosis. National consensus of the Belgian Bone Club"
Kaufman, JM; Devogelaer, JP; Raeman, F et al

in Clinical Rheumatology (1997), 16(4), 343-345

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See detailBeam-laser measurements and relativistic Hartree-Fock calculations of the lifetimes of the 3d94p levels in Cu II
Pinnington, E. H.; Rieger, G.; Kernahan, J. A. et al

in Canadian Journal of Physics (1997), 75

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See detailIntratumoral heterogeneity for hsp90 mRNA levels in a breast cancer cell line
Luparello, C.; Noël, Agnès ULg; Pucci-Minafra, I.

in DNA & Cell Biology (1997), 16

BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to ... [more ▼]

BC-3A and BC-61 are two breast cancer cell lines that have been cloned from parental 8701-BC cells and exhibit different biosynthetic, proliferative, and invasive properties in vitro. In the attempt to search whether alterations in the profiles of gene expression could be detected, we have submitted both cytotypes to identification of differentially expressed cDNAs. In addition, steroid hormone receptor mRNA arrays and in vivo tumorigenesis of the two lines have been checked. The technique used allowed identification of changes in the expression of the 90-kD heat shock protein-beta (hsp90beta) which is prominently down-regulated in BC-61 cells. Because we have also found that these cells, which lack estrogen receptor mRNA synthesis, display a more invasive behavior in vitro and increased tumorigenesis in vivo, we propose that evaluation of hsp903 transcript levels may be taken into consideration for screening as a novel molecular marker of breast cancer progression. [less ▲]

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See detailFontes Graeci Sami, I. Η Σάμος στις πηγές από τον 8ο ως τον 6ο αι.
Vanhaegendoren, Koen ULg; Karla, Grammatiki

in Samiakes Meletēs (1997), 3

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See detailThéorie de l'approche hydrogéologique des écoulements et transports en zone partiellement saturée
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1997), 119(1), 71-89

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See detailThe role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids.
El Ouahabi, A.; Thiry, Marc ULg; Pector, V. et al

in FEBS Letters (1997), 414(2), 187-92

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three ... [more ▼]

We used a 32P-labeled pCMV-CAT plasmid DNA to estimate the DNA uptake efficiency and unlabeled pCMV-CAT plasmid DNA to quantify the CAT activity after transfection of COS cells using each of the three following cationic compounds: [1] vectamidine (3-tetradecylamino-N-tert-butyl-N'-tetradecylpropionamidine, and previously described as diC14-amidine [1]), [2] lipofectin (a 1:1 mixture of N-(1-2,3-dioleyloxypropyl)-N,N,N-triethylammonium (DOTMA) and dioleylphosphatidylethanolamine (DOPE)), and [3] DMRIE-C (a 1:1 mixture of N-[1-(2,3-dimyristyloxy)propyl]-N,N-dimethyl-N-(2-hydroxyethyl) ammonium bromide (DMRIE) and cholesterol). Surprisingly, a high CAT activity was observed with vectamidine although the DNA uptake efficiency was lower as compared to lipofectin and DMRIE-C. Transmission electron microscopy (TEM) revealed endocytosis as the major pathway of DNA-cationic lipid complex entry into COS cells for the three cationic lipids. However, the endosomal membrane in contact with complexes containing vectamidine or DMRIE-C often exhibited a disrupted morphology. This disruption of endosomes was much less frequently observed with the DNA-lipofectin complexes. This comparison of the three compounds demonstrate that efficient transfection mediated by cationic lipids is not only correlated to their percentage of uptake but also to their ability to destabilize and escape from endosomes. [less ▲]

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See detailFeeding of the sparid fish Sarpa salpa in a seagrass ecosystem: Diet and carbon flux
Havelange, S.; Lepoint, Gilles ULg; Dauby, Patrick ULg et al

in Marine Ecology (1997), 18(4), 289-297

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ... [more ▼]

In Revellata Bay (Gulf of Calvi, Corsica, France), the sparid fish Sarpa salpa L. is the main macro-consumer of Posidonia oceanica (L.) DELILE leaf. Stomach contents were analysed and C-13/C-12 isotopic ratios were measured in fish muscle and potential food sources (algae, P. oceanica leaf and its epiphytes) to determine their relative contribution to the fish diet. S. salpa has an age-related mixed diet: juveniles are plankton feeders, young, sub-adults and adults are herbivorous, and, the older the individuals, the higher the relative contribution of P. oceanica to the diet. Our results and former studies of carbon stocks and fluxes in the P. oceanica bed of Revellata Bay have enabled an estimation of the general impact of S. salpa grazing on infralittoral communities: the studied species consumes 24 g C.m-2.a(-1) from P. oceanica leaf, 4.8 from epiphytes and 13 from epilithic algae. The fish net production and biomass turnover in that zone have been estimated to be 1.2 g C.m(-2).a(-1) and 1.5 a(-1), respectively. [less ▲]

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See detailInduction of membrane-type matrix metalloproteinase 1 (MT1-MMP) expression in human fibroblasts by breast adenocarcinoma cells.
Polette, M.; Gilles, Christine ULg; Marchand, V. et al

in Clinical & Experimental Metastasis (1997), 15(2), 157-63

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in situ hybridization that MT1-MMP ... [more ▼]

Membrane-type matrix metalloproteinase 1 (MT1-MMP) has been recently described as an activator of proMMP-2 (MMP-2) which is involved in tumor invasion. We have shown by in situ hybridization that MT1-MMP is produced by stromal cells in close contact to preinvasive and invasive tumor cells of breast carcinomas. Of particular interest was the observation that some fibroblasts express this enzyme in focal areas in preinvasive lesions, suggesting that particular tumor cells may stimulate fibroblasts to produce MT1-MMP. We have therefore compared the ability of two different breast cancer cell lines, one non-invasive (MCF7) and one invasive (MDA-MB-231) to stimulate MT1-MMP production in human fibroblasts with consequent proMMP-2-activation. The MDA-MB-231 conditioned medium induced MT1-MMP mRNAs in human fibroblasts and a parallel activation of proMMP-2 whereas MCF7 conditioned medium did not have any effect. These results suggest the existence of soluble factor(s) secreted by invasive or some preinvasive breast tumor cells which stimulate fibroblasts to produce and activate MMPs, and emphasize the cooperation between cancer and stromal cells in tumor invasion. [less ▲]

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See detailThe Spectrum of Ne V
Bastin, Thierry ULg; Biémont, Emile ULg; Dumont, Paul-Dominique ULg et al

in Physica Scripta (1997), 55

A new investigation of the Ne V spectrum is reported. The beam-foil method has been used to produce spectra at two different energies (1.2 MeV and 2.5 MeV) between 450 and 11OOA Sixty-five lines of Ne V ... [more ▼]

A new investigation of the Ne V spectrum is reported. The beam-foil method has been used to produce spectra at two different energies (1.2 MeV and 2.5 MeV) between 450 and 11OOA Sixty-five lines of Ne V have been newly identified. Fifty levels have been determined for the first time and energies have been revised for seven levels. [less ▲]

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See detailCompte rendu de L.C. Youtie, P. Michigan 17. The Michigan Medical Codex (P. Mich. 758 = P. Mich. inv. 21), Atlanta, 1996 (American Studies in Papyrology, 35)
Marganne, Marie-Hélène ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1997), 72

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See detailUsing the Global Positioning System to monitor active faults in “stable continental Europe”
Warnant, René ULg

in Aardkundige Mededelingen (1997), 8

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See detailCombined Ring Inversion and Side Group Rotation in Geminal Diphosphoryl Substituted Pyrrolinoxyl Radicals: ESR Analysis of Chemical Exchange between Four Nonequivalent Sites
Rockenbauer, Antal; Mercier, Anne; Le Moigne, François et al

in Journal of Physical Chemistry A (1997), 101(43), 7965-7970

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found ... [more ▼]

The ESR spectra of three diphosphorylated pyrrolidinoxyl radicals have been studied over a large temperature range. While for the trans 2,5-disubstituted compound 1 no line width alternation was found, for the 2,2-disubstituted compounds 2 and 3, dramatic changes in the spectra were observed as a function of the temperature. These changes were explained by a four-site chemical exchange model including both ring inversion and hindered rotation around the carbon-phosphorus bonds. For radical 3, the presence of additional 5,5-dimethyl substitution can completely block rotations around carbon-phosphorus bonds for certain ring geometries, while for other ring conformations chemical exchange still occurs through combined inversionrotation processes. An effective two-site model composed of nonequivalent sites and a superposition model composed of a pair of exchanging conformers and a pair of nonexchanging conformers were used to simulate spectrum variations. A satisfactory fit was obtained over the entire temperature range investigated. From the temperature dependence of the exchange frequencies the potential barriers for ring inversion (27 kJ/mol), for combined inversion-rotation (11 kJ/mol), and for rotation around the carbon-phosphorus bonds (14 kJ/mol) were estimated. [less ▲]

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See detailSurveillance des états hypertensifs sévères
Brichant, Jean-François ULg

in Percentile (1997), 2

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See detailLe cas clinique du mois, A propos d'un cas de myelinolyse centropontique chez un éthylique chronique
Lebrun, F.; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in Revue Médicale de Liège (1997), 52(1), 7-11

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See detailSurveys of ultraviolet-excess quasar candidates in large fields
Gosset, Eric ULg; Moreau, O.; Surdej, Jean ULg et al

in Astronomy and Astrophysics. Supplement Series (1997), 123

We describe the results of a survey for moderately bright quasars performed in a 20.6-square-degree field around the galaxy NGC 450. The quasar candidates were selected on the basis of their ultraviolet ... [more ▼]

We describe the results of a survey for moderately bright quasars performed in a 20.6-square-degree field around the galaxy NGC 450. The quasar candidates were selected on the basis of their ultraviolet excess: by comparative visual inspection of the double image of each single object on a U/B dual-exposure Schmidt photographic plate, 95 primary and 45 secondary quasar candidates were selected on the basis of their $U$ image being too bright. The spectroscopic identification of the primary candidates led to the discovery of 59 bona fide quasars (out of which 6 were previously known). The Palomar Schmidt plate was digitised using the MAMA measuring machine and the outcoming data reduced using ad hoc procedures. A photometric calibration allowed us to derive values for the limiting magnitudes and for the U-B index selection threshold of the survey. A catalogue containing 60 quasars is presented with accurate positions, magnitudes and additional information such as redshifts. We studied the spatial distribution of the objects and detected, for the quasars of our sample, a significant deviation from randomness in the form of a propensity to cluster in pairs on the celestial sphere with a typical scale of about 10 arcmin. We also formally detected a tendency towards a 3-D clustering, but this result is induced by a single pair of quasars. A forthcoming paper will deal with a similar work performed in a field around NGC 520; the latter field is located directly to the North of the present one and slightly overlaps it. Based on observations acquired at the Mount Palomar and Las Campanas Observatories as well as at the European Southern Observatory. Also based on Schmidt-plate digitisations performed with the MAMA measuring machine of C.A.I. (I.N.S.U., Paris). [less ▲]

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See detailAssociative chunk strength in artificial grammar learning
Meulemans, Thierry ULg; Van der Linden, Martial ULg

in Journal of Experimental Psychology. Learning, Memory & Cognition (1997), 23(4), 1007-1028

In four experiments, adherence to grammatical rules and associative chunk strength (including different measures, each calculated on the basis of the frequency with which bigrams and trigrams present in ... [more ▼]

In four experiments, adherence to grammatical rules and associative chunk strength (including different measures, each calculated on the basis of the frequency with which bigrams and trigrams present in the test strings appeared in the learning strings) were manipulated independently in the test phase of an artificial grammar learning task. When participants learned few items of the grammar (Experiments 1a and 2a), the associated items were more often classified as grammatical than the nonassociated ones. On the other hand, when the learning phase included most of the grammatical items (Experiments 1b and 2b), the only effect observed was an effect of grammaticality. These results suggest that, depending on the specific constraints of the tasks, knowledge based on bigrams and trigrams and knowledge based on the abstraction of the grammatical structure can be used for the classification task. [less ▲]

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See detailPsychrophiles et thermophiles : un problème d’enzyme
Gerday, Charles ULg; Aittaleb, M.; Arpigny, J. L. et al

in Chimie Nouvelle (1997), 15

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See detailDe l’acyclovir au valacyclovir: la biodisponibilité en plus de l’efficacité et de la tolérance
Rentier, Bernard ULg

in Virologics (1997), (Septembre), 10-11

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See detailEfficiency and productivity of the insurance industry in the OECD countries
Fecher-Bourgeois, Fabienne ULg; Donni, Olivier

in Geneva Papers on Risk & Insurance - Issues & Practice (1997), 22(No. 85, October 1997), 523-535

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See detailUne chambre noire pour l’analyse textuelle
Tilkin, Françoise ULg; Mathonet, Anne

in Espace pour un humanisme européen (1997), 33

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See detailEngraissement du taurillon Blanc-Bleu belge
Minet, Vincent; Van Eenaeme, Christian ULg; Raskin, Pascale et al

in Agricontact (1997), 291

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See detailAdvantages of Inferior Vena Caval Flow Preservation in Combined Transplantation of the Liver and Heart
Detry, Olivier ULg; Honore, Pierre ULg; Meurisse, Michel ULg et al

in Transplant International (1997), 10(2), 150-1

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of ... [more ▼]

Only a few cases of combined liver and heart transplantation have been reported in the literature, and no standard surgical procedure has yet been established. We report the successful transplantation of both liver and heart in a 28-year-old patient suffering from homozygous beta-thalassemia. We used Belghiti's technique of inferior vena caval flow preservation for liver transplantation, which avoids inferior vena cava occlusion by a side-to-side caval anastomosis. Applied to combined liver and heart transplantation, preservation of caval flow during liver transplantation may allow early discontinuation of cardiopulmonary bypass and, thus, minimize the general consequences of prolonged bypass. [less ▲]

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See detailThe state of stress near the Mendocino triple Junction from inversion of earthquake focal mechanism
Schwartz, S. Y.; Hubert, Aurelia ULg

in Geophysical Research Letters (1997), 23

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See detailBiomechanical assessment of the transversalis fascia and rectus abdominis aponeurosis in inguinal herniation - Preliminary results
PANS, Alain ULg; Pierard, Gérald ULg; Albert, Adelin ULg et al

in Hernia : the Journal of Hernias & Abdominal Wall Surgery (1997), 1

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See detailNucleon nucleon interaction in a chiral constituent quark model
Stancu, Floarea ULg; Pepin, S.; Glozman, L Ya

in Physical Review. C : Nuclear Physics (1997), C56

We study the short-range nucleon-nucleon interaction in a chiral constituent quark model by diagonalizing a Hamiltonian comprising a linear confinement and a Goldstone boson exchange interaction between ... [more ▼]

We study the short-range nucleon-nucleon interaction in a chiral constituent quark model by diagonalizing a Hamiltonian comprising a linear confinement and a Goldstone boson exchange interaction between quarks. The six-quark harmonic oscillator basis contains up to two excitation quanta. We show that the highly dominant configuration is $\mid s^4p^2[42]_O [51]_{FS}>$ due to its specific flavour-spin symmetry. Using the Born-Oppenheimer approximation we find a strong effective repulsion at zero separation between nucleons in both $^3S_1$ and $^1S_0$ channels. The symmetry structure of the highly dominant configuration implies the existence of a node in the S-wave relative motion wave function at short distances. The amplitude of the oscillation of the wave function at short range will be however strongly suppressed. We discuss the mechanism leading to the effective short-range repulsion within the chiral constituent quark model as compared to that related with the one-gluon exchange interaction. [less ▲]

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See detailThe application of spatial autocorrelation methods to the study of Calluna vulgaris population genetics
Mahy, Grégory ULg; Néve, Gabriel

in Belgian Journal of Botany (1997), 129

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See detailThe two beta-lactamase genes of Streptomyces cacaoi, blaL and blaU, are under the control of the same regulatory system.
Magdalena, J; Gérard, Christine; Joris, Bernard ULg et al

in Molecular & General Genetics [=MGG] (1997), 255(2), 187-93

The production of beta-lactamase in Streptomyces cacaoi, which contains two beta-lactamase-encoding genes, blaL and blaU, is inducible by beta-lactam compounds. The two genes have been cloned ... [more ▼]

The production of beta-lactamase in Streptomyces cacaoi, which contains two beta-lactamase-encoding genes, blaL and blaU, is inducible by beta-lactam compounds. The two genes have been cloned independently in S. lividans TK24, a beta-lactamase-negative species. The blaU clone did not respond to the presence of beta-lactams, whereas the blaL clone appeared to be inducible in S. lividans. The latter clone contains two open reading frames, blaA and blaB, located just upstream of but transcribed divergently from blaL, which were shown to be required for the production as well as the induction of BlaL. The deduced BlaA protein belongs to the LysR family of transcription regulators. In order to examine the role of BlaA in regulation, we here report on over-expression of a GST-BlaA fusion protein in Escherichia coli and its use for antibody preparation. The GST-BlaA fusion protein was partially purified and bandshift assays showed that it bound the 197-bp blaL-blaA intergenic region. The BlaA DNA binding-site was further restricted to a 30-bp sequence containing a T-N11-A motif, a characteristic of LysR-type promoters. Another T-N11-A motif upstream of the blaU gene was also shown to bind BlaA. The affinities of these two T-N11-A motifs in BlaA binding were comparable. A plasmid bearing the blaU structural gene and the blaA-blaB regulatory region was constructed and shown to confer on an S. lividans host the capacity to produce inducible beta-lactamase. It can thus be concluded that the S. cacaoi blaL and blaU genes are controlled by the same regulatory system. [less ▲]

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See detailPalynological evaluation of the Famennian Protosalvinia (Foerstia) Zone in the Amazon basin, Northern Brazil : a preliminary study.
Loboziak; Melo, J.H.G.; Quadros, L.P. et al

in Review of Palaeobotany and Palynology (1997), 96

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See detailNon délivrance et infécondité: intérêts de l’étiproston et du dosage de la PAGI (pregnancy-associated glycoprotein I) au cours du postpartum chez la vache.
Zaiem, I.; Tainturier, D.; Ben Othmen, H. et al

in Revue de Médecine Vétérinaire (1997), 148(8-9), 725-732

Sixty Prim'holstein cows with retained placenta for more than 24 hours after parturition, were shared in three groups of 20 cows each. All cows were delivred manually 24 to 36 hours post partum and ... [more ▼]

Sixty Prim'holstein cows with retained placenta for more than 24 hours after parturition, were shared in three groups of 20 cows each. All cows were delivred manually 24 to 36 hours post partum and received local treatment with 1 g of oxytetracyclin. Cows in group 1 received two intra-muscular injections of 5 mg etiproston on day of manual delivery (D1) and 15 days after (D15). Cows on group II received only one etiproston administration (D1), and cows in group III remained untreated. Ratios of delayed uterine involution were respectively 20, 40 and 55 % in groupsI,II and III(I<0.05;II<0.005). PAGI concentrations were checked 15 days after parturition and were significantly higher in cows affected by delayed uterine involution (p < 0.05). V-IAF intervals were significantly (p < 0.05) different between groups I (58 days), II (102 days) and III(143 days). [less ▲]

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See detailEndoscopic laser treatment of uterine malformations.
Donnez, Jacques; NISOLLE, Michelle ULg

in Human Reproduction (1997), 12(7), 1381-7

Hysteroscopic resection of an intrauterine septum may benefit patients suffering from infertility or recurrent pregnancy loss. A partial or complete uterine septum can be easily resected using a Nd-YAG ... [more ▼]

Hysteroscopic resection of an intrauterine septum may benefit patients suffering from infertility or recurrent pregnancy loss. A partial or complete uterine septum can be easily resected using a Nd-YAG laser. If present, the vaginal septum may also be removed during the same procedure. The reproductive outcome of women treated by operative hysteroscopy for an intrauterine septum is reviewed. To avoid pregnancy in a non-communicating rudimentary horn, the removal of the horn and the homolateral tube may be performed by either bipolar coagulation or a CO2 laser. [less ▲]

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See detailProductivity and Convergence in OECD Service Industries
Gouyette, Claudine; Perelman, Sergio ULg

in Structural Change and Economic Dynamics (1997), 8

The objective of this paper is threefold. First, to estimate the productivity performances realized in service and manufacturing industries by 13 OECD countries over the period 1970-1987. Secondly, to ... [more ▼]

The objective of this paper is threefold. First, to estimate the productivity performances realized in service and manufacturing industries by 13 OECD countries over the period 1970-1987. Secondly, to compare the productivity indicators computed under the alternative frontier analysis and Divisia index approaches. Thirdly, to test the convergence phenomenon in both industries, focusing on the catching-up process and on the interaction between productivity changes and capital intensity variations. The main results show that, contrary to the manufacturing sector and in spite of very low growth rates, productivity levels converge in services. Moreover, new investments in capital appear to exert an unexpected depressive effect on total factor productivity growth in service activities, while having a positive influence in manufacturing industries. [less ▲]

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See detailThe veno-occlusive disease of the liver.
Baron, Frédéric ULg; Deprez, Manuel ULg; Beguin, Yves ULg

in Haematologica (1997), 82(6), 718-25

BACKGROUND AND OBJECTIVE: The veno-occlusive disease of the liver (VOD) is a disorder caused by the non-thrombotic occlusion of the central veins of hepatic lobules. The clinical features are similar to ... [more ▼]

BACKGROUND AND OBJECTIVE: The veno-occlusive disease of the liver (VOD) is a disorder caused by the non-thrombotic occlusion of the central veins of hepatic lobules. The clinical features are similar to those of intrahepatic portal hypertension (unexplained weight gain, ascites, painful hepatomegaly, jaundice). In the past, this disease was rather infrequent and was linked to the absorption of toxic agents, liver irradiation or chemotherapy. However, the intensification of treatment protocols before hematopoietic stem cell transplants has considerably increased its incidence. The strategies used for its prevention and treatment remain limited in efficacy. The present review was undertaken in order to assess progress in the diagnosis and management of this severe complication in stem cell transplantation. INFORMATION SOURCES: The method used for preparing this review was an examination of 250 relevant articles or abstracts published in journals covered by Medline. STATE OF ART: Despite the progress made toward the understanding of its physiopathology and the identification of its risk factors, VOD is still one of the leading causes of morbidity and mortality during the first two months post-BMT, and therefore often constitutes a limitation for the further increment of the dose of antineoplastic drugs. This may be explained by the difficulty in making an early diagnosis of this problem, at a time when therapeutic intervention may be more effective, and, on the other hand, the lack of a well-established prevention and treatment approach for patients with VOD. PERSPECTIVES AND CONCLUSIONS: New diagnostic procedures, such as laparoscopic liver biopsy, and new therapeutic approaches, such as transjugular intrahepatic portosystemic shunting (TIPS) or defibrotide, are now being evaluated. However, additional studies will be needed to determine the most appropriate therapy for each VOD patient depending on the severity of the disease. [less ▲]

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See detailTrajectoire déviante à la lisière entre adolescence et âge adulte
Gavray, Claire ULg

in Déviance et Société (1997), 21(3), 273-288

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See detailQuelques arthropodes de nos maisons
Loneux, Michèle ULg

in Cahiers d'Ethologie (1997), 17(1), 75-124

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See detailOptimization of murine CD8+ cytotoxic T-lymphocyte responses to pseudorabies virus
Depierreux, C.; Graff, I.; Lancelot, V. et al

in Journal of Immunological Methods (1997), 203

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See detailLe bois de tension. 1 Définition et distribution dans l'arbre.
Jourez, Benoît ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(2), 100-112

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See detailcompte rendu de : J. Martinez-Pinna, Tarquinio Prisco. Ensayo historico sobre Roma arcaica
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (1997), (3), 280

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See detailA domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.
Jousset, C.; Carron, C.; Boureux, A. et al

in EMBO Journal (1997)

TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino ... [more ▼]

TEL is a novel member of the ETS family of transcriptional regulators which is frequently involved in human leukemias as the result of specific chromosomal translocations. This study shows that the amino-terminal domain conserved in a subset of the ETS proteins has evolved to generate a specialized protein-protein interaction interface which is likely to be an important determinant of their specificity as transcriptional regulators. [less ▲]

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See detailVaccinia virus immune evasion
Smith, G. L.; Symons, J. A.; Khanna, A. et al

in Immunological Reviews (1997), 159

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include ... [more ▼]

Vaccinia virus and other poxviruses express a wide variety of proteins which are nonessential for virus replication in culture but help the virus to evade the host response to infection. Examples include proteins which oppose apoptosis. Synthesise steroids, capture chemokines, counteract complement, interfere with interferon and intercept interleukins. This review provides an overview of such proteins, with an emphasis on work from our laboratory, and illustrates how the study of these proteins can increase our understanding of virus pathogenesis, the function of the immune system and how to make safer and more immunogenic poxvirus-based vaccines. [less ▲]

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See detailA new generation of hydrocolloid dressings in combination with topical corticosteroids in the treatment of psoriasis vulgaris
Dezfoulian, Bita ULg; de LA BRASSINNE, Michel ULg; Rosillon, D.

in Journal of the European Academy of Dermatology & Venereology (1997), 9

Aim : A clinical, randomized, parallel, multicenter study was undertaken to compare the efficacy and Ihe tolerability of two known steroid creams, betamethasone 17-valerate and clobetasol propionate ... [more ▼]

Aim : A clinical, randomized, parallel, multicenter study was undertaken to compare the efficacy and Ihe tolerability of two known steroid creams, betamethasone 17-valerate and clobetasol propionate, alone or left under a hydrocolloid dressing (Contreei'* Derma Cover), in the treatment of chronic plaques of psoriasis. Methods : A total of 70 patients with symmetrical localized psoriasis were divided randomly into two groups for the study. Each patient applied ihe corticosteroid preparation under Contreet° Derma Cover once a week on one plaque and the same topical corticosteroid alone h.i.d on the other plaque; the treatment lasted 3 weeks for betamethasone 17-valerate, and 2 weeks for clobetasol propionate. Results : The heahng rate reached 79% with the Contreet" combined treatment versus 15% (P < 0,0001) with the standard treatment for betamethasone 17-valeratc (group I) and Sb% versus 14*70 (P < 0. 0001) for clobetasol propionate (group It). The mean difference in healing rate was 65% {95% confidence interval (C.I), 46-84%) and 69% (95% CL, 50-87%) in groups I and II, respectively. Conclusion : The use of the new generation of hydrocolloid dressings in combination with steroid preparations can be considered as another therapeutic option for the treatment of chronic localized psoriatic lesions. Furthermore, with this method the amount of the topical corticosteroid used can be reduced. [less ▲]

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See detailTransplantation combinée du foie et du coeur chez un patient souffrant de thalassémie majeure
Detry, Olivier ULg; Defechereux, Thierry ULg; Honore, Pierre ULg et al

in Revue Médicale de Liège (1997), 52(8), 532-4

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See detailDevelopment of a positron emission tomography radiopharmaceutical for imaging thymidine kinase gene expression : Synthesis and in vitro evaluation of 9-{3-[18F] Fluoro-1-hydroxy-2-propoxymethyl guanine
Monclus, Michel; Luxen, André ULg; Cool, Vincent et al

in Bioorganic and Medicinal Chemistry Letters (1997), 7(14), 1879-1882

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission ... [more ▼]

9-[(3-fluoro-1-hydroxy-2-propoxy)methyl]guanine (FHPG) 2 has been labeled with fluorine-18 and evaluated in vitro as a potential radiotracer for mapping gene expression in vivo with positron emission tomography (PET). [less ▲]

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See detailMéthodes de stereologie et de morphometrie appliquées a l'etude des poumons
Jolly, S.; Gabriel, Annick ULg; Desmecht, Daniel ULg et al

in Annales de Médecine Vétérinaire (1997), 141

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See detailConcordanze del «Canto novo» di Gabriele d’Annunzio.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1997)

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See detailLettre de Biélorussie
Mouton, Charles ULg

in Revue Générale (1997), (8/9), 79-86

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See detailEffect of beef type, body weight and dietary protein content on voluntary feed intake, digestibility, blood and urine metabolites and nitrogen retention
Fiems, Leo; Cottyn, B. G.; Boucqué, Charly et al

in Journal of Animal Physiology & Animal Nutrition (1997), 77

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See detailLe concept de qualité de vie
Etienne, Anne-Marie ULg; Fontaine, Ovide ULg

in Revue Francophone de Clinique Comportementale et Cognitive (1997), II(3), 16-25

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la ... [more ▼]

Les auteurs examinent les problèmes rencontrés pour définir et mesurer la qualité de vie. Il se dégage des multiples définitions un ensemble de propriétés et de caractéristiques telles que la multifactorialité, l'auto-évaluation, la variabilité temporelle et la subjectivité. De plus, l'étude comparative des multiples outils existants devrait permettre d'affiner leur spécificité et donc aider à la compréhension du concept... [less ▲]

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See detailDevelopment of a monoclonal antibody to urinary degradation products from the C-terminal telopeptide 1 chain of type I collagen. Application in an enzyme immunoassay and comparison to Crosslaps TM Elisa
Fledelius, C; Kolding, I; Qvist, P et al

in Scandinavian Journal of Clinical & Laboratory Investigation (1997), 57

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See detailWhat Is the Risk of Transferral of an Undetected Neoplasm During Organ Transplantation?
Detry, Olivier ULg; Bonnet, Pierre ULg; Honore, Pierre ULg et al

in Transplantation Proceedings (1997), 29(5), 2410-1

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See detailMesures d'incitation en faveur de la conservation de la diversite genetique en matiere agricole. 2. Analyse des mesures agri-environnementales belges.
Lepoivre, Philippe ULg; Baltus, Carine

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1997), 1(3), 187-195

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See detailProduction and activation of matrix metalloprotease-9 (MMP-9) by HL-60 promyelocytic leukemia cells
Devy, L.; Noël, Agnès ULg; Baramova, E. et al

in Biochemical and Biophysical Research Communications (1997), 238

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of ... [more ▼]

Human promyelocytic HL-60 cells have been used as a model of acute leukemia to investigate the expression and the regulation of matrix metalloproteases (MMPs), known to contribute to the degradation of extracellular matrix components. As shown by gelatin zymography, HL-60 cells constitutively released significant amounts of proMMP-9 (92 kDa) and moderate amounts of proMMP-2 (72 kDa). Furthermore, casein zymography confirmed the presence of serine proteases in the form of pro-urokinase. Activation of proMMP-9 was dependent on the plasminogen activator/plasmin (PA/plasmin) system and was inhibited by aprotinin. MMP-9 was only detected in cellular extracts or conditioned media incubated with HL-60 cells, indicating that cells are essential to the activation process. Addition of plasminogen increased by 3-fold the basal invasive rate of these cells across a matrigel layer (2.1%versus0.7% in control cells after 4 h of incubation). Taken together, these results indicate that HL-60 cells exhibit an autocrine activation mechanism of proMMP-9 via the PA/plasmin system and that activation of proMMP-9 increases their invasive potential [less ▲]

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See detailA primal-dual approach in truss topology optimization
Beekers, M.; Fleury, Claude ULg

in Computers & Structures (1997), 64(1-4), 77-88

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are ... [more ▼]

The objective of truss topology optimization is to find, for a given weight, the stiffest truss, defined as a subset of an initially choosen set of bars called the ground structure. The restrictions are bounds on bar volumes and the satisfaction of equilibrium equations. For a single load case and without bounds on bar volumes, the problem can be written as a linear programming problem with nodal displacements as variables. The addition to the objective function of a quadratic term vanishing at the optimum allows us to use a dual solution scheme. A conjugate gradient method is well suited to maximize the dual function. Several ground structures are introduced. For large networks, those where each node is connected to those situated in a certain vicinity give a good compromise between generating a reasonable number of bars and obtaining a sufficient number of possible directions. Some examples taken from the literature are treated to illustrate the quality of the solution and the influence of initial topology. (C) 1997 Civil-Comp Ltd and Elsevier Science Ltd. [less ▲]

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See detailTwo centuries of vaccination
Vanderplasschen, Alain ULg; Smith, G. L.

in Annales de Médecine Vétérinaire (1997), 141

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See detailGenetic markers may predict disease behavior in patients with ulcerative colitis.
Roussomoustakaki, M.; Satsangi, J.; Welsh, K. et al

in Gastroenterology (1997), 112(6), 1845-53

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The ... [more ▼]

BACKGROUND & AIMS: Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively. The aim of this study was to test these hypotheses in patients undergoing surgery for their colitis. METHODS: HLA DRB1 and DQB1 genotyping was performed in 99 patients and 472 controls. Genotyping for polymorphisms of genes encoding tumor necrosis factor alpha and IL-1RA was performed in 107 patients and 89 controls. Measurement of antineutrophil cytoplasmic antibody (ANCA) was performed in 72 patients and 58 healthy subjects by fixed neutrophil enzyme-linked immunosorbent assay and indirect immunofluorescence. RESULTS: The DRB1*0103 allele was increased in patients (14.1% vs. 3.2% in controls; P < 1 x 10[-5]). This association was greatest in patients with extensive disease (15.8%; P < 0.0001) or extraintestinal manifestations (22.8%; P < 0.0001): mouth ulcers (25.8%; P < 0.0001), arthritis (27.2%; P < 0.0001), and uveitis (35.7%; P < 0.0001). The DRB1*04 alleles were reduced in patients (P = 0.005). Differences were noted between extensive and distal disease in the frequency of allele 2 of IL-1RA (10.9% in distal vs. 28.6% in extensive; P = 0.01) and allele 2 homozygosity. ANCA was detected in 76.4% of patients. Carriage of IL-1RA allele 2 and tumor necrosis factor 2 allele was increased in ANCA-positive patients. CONCLUSIONS: Genetic markers may predict disease behavior in ulcerative colitis. [less ▲]

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See detail67-kD laminin receptor expression correlates with worse prognostic indicators in non-small cell lung carcinomas.
Fontanini, G.; Vignati, S.; Chine, S. et al

in Clinical Cancer Research : An Official Journal of the American Association for Cancer Research (1997), 3(2), 227-31

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67 ... [more ▼]

Tumor samples obtained from 72 patients resected for non-small cell lung cancer were stained immunohistochemically using an immunoperoxidase method and the MLuC5 monoclonal antibody specific for the 67-kDa laminin receptor. Sixty-one of 72 patients (84.7%) displayed a MLuC5-positive reaction, which was usually localized in both the inner surface of the plasmatic membranes and the cytoplasm of neoplastic cells. When we compared the laminin receptor expression with clinicopathological and biological parameters such as histotype, grading, T status, N status, ploidy, proliferative activity, vessel invasion, and p53 protein accumulation, the following results were observed: (a) the mean expression of the receptor was higher in the group of patients with metastatic nodal involvement than in those with uninvolved lymph nodes (P = 0.02); (b) a high Ki-67 score (>13% of positive cells) was observed in tumors with a higher mean value of laminin receptor (P = 0.004); (c) the tumors harboring neoplastic emboli in their vessels showed a higher laminin receptor immunoreactivity (P = 0.02); and (d) a borderline association was found between the high mean value of laminin receptor immunopositivity and p53 accumulation in neoplastic cell nuclei (P = 0.05). Our observations indicate that detection of high tissue levels of 67-kDa laminin receptor is associated with an invasive phenotype in non-small cell lung cancer and may provide further information in the biological characterization of this type of cancer. [less ▲]

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See detailReversibility of thiamine deficiency-induced partial necrosis and mitochondrial uncoupling by addition of thiamine to neuroblastoma cell suspensions.
Bettendorff, Lucien ULg; Goessens, Guy ULg; Sluse, Francis ULg

in Molecular and Cellular Biochemistry (1997), 174(1-2), 121-4

Culture of neuroblastoma cells in the presence of low thiamine concentration (16 nM) and of the transport inhibitor amprolium leads to the appearance of signs of necrosis: the chromatin condenses, the ... [more ▼]

Culture of neuroblastoma cells in the presence of low thiamine concentration (16 nM) and of the transport inhibitor amprolium leads to the appearance of signs of necrosis: the chromatin condenses, the oxygen consumption decreases and is uncoupled, the mitochondrial cristae are disorganized, the thiamine diphosphate-dependent dehydrogenase activities are impaired. When 10 microM thiamine are added to these cells, the basal respiration increases, the coupled respiration is restored and mitochondrial morphology is recovered within 1 h. Addition of succinate, which is oxidized via a thiamine diphosphate-independent dehydrogenase, to digitonin-permeabilized cells immediately restores a coupled respiration. Our results suggest that the slowing of the citric acid cycle is the cause of the biochemical lesion induced by severe thiamine deficiency and that part of the mitochondria remain functional. [less ▲]

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See detailTrois ivoires médiévaux au Musée de l’Oeuvre Notre-Dame à Strasbourg
Van den Bossche, Benoît ULg

in Cahiers Alsaciens d’Archéologie, d’Art et d’Histoire (1997), XL

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See detailRégime et tactique alimentaires de la loutre (Lutra lutra) dans le Massif Central
Libois, Roland ULg

in Vie et milieu (1997), 47(1), 33-45

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback ... [more ▼]

Otter spaints were collected in 1991 on a seasonal basis in the river Chavanon catchment, a tributary of the river Dordogne, in central France. Small sized species (bullhead, three-spined stickleback, gudgeon and minnow) are the most numerous items in the diet: they account for more than 50% of the 3,148 identified preys. However, when expressed in relative biomass, their importance falls down (8 %). In fact, the brown trout, large cyprinid fish, birds and mammals make up the bulk of the diet. We found strong differences linked to the general habitat types and also seasonal ones. Frogs are mainly preyed upon during the spring whereas the snakes are exclusively taken in the summer and autumn months. Gudgeon and insects are also mainly summer and autumn preys. Perch and large cyprinid fish remais are more frequent during winter and even spring. The present results confirm the opportunistic way of predation of the otter and the fact that its hunting takes place more on the bottom and along the river banks than in the open water. [less ▲]

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See detailCompte rendu de VAUCHEZ (A.), La spiritualité du Moyen Age occidental VIIIe-XIIIe siècle, Paris, 1994
George, Philippe ULg

in Revue Belge de Philologie et d'Histoire (1997)

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