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See detailVapor-Liquid Equilibria in Quaternary Mixtures of Dimethyl Ether + n-Butane + Etha-nol + Water
Dahlhoff, Gerd; Pfennig, Andreas ULg; Hammer, Hartmut et al

in Journal of Chemical & Engineering Data (2000), 45(5), 887-892

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See detailFormation des enseignants et évaluation : L'évolution depuis 1995
Beckers, Jacqueline ULg

in TNTEE (Thematic Network for Teacher Education in Europe) (2000)

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See detailSkin Tensile Strength Modulation by Compressive Garments in Burn Patients. A Pilot Study
Fournier, R.; Pierard, Gérald ULg

in Journal of Medical Engineering & Technology (2000), 24(6, Nov-Dec), 277-80

Compression therapy is frequently used to prevent hypertrophy of post-burn scars. This pilot study was performed in 6 patients to assess non-invasive changes induced in the tensile strength of the skin ... [more ▼]

Compression therapy is frequently used to prevent hypertrophy of post-burn scars. This pilot study was performed in 6 patients to assess non-invasive changes induced in the tensile strength of the skin before any clinical improvement can be perceived. Assessments were performed using a computerized suction device delivering three 5 s cycles of 500 mbar depression. Measurements were made at one-month intervals for three months after initiating the garment compression therapy. Comparisons were made between the intact skin, the ungrafted and grafted post-burn scars and the graft donor sites. Data show that garment compression therapy alters the tensile strength in the skin of all test sites. The most reliable variations consist of an increase in both the extensibility and elasticity of the tissues submitted to traction. [less ▲]

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See detailChanging dynamics of the Loire river in Burgundy (France) during the last 200 years
Leteinturier, B.; Engels, Patrick ULg; Petit, François ULg et al

in Géomorphologie : Relief, Processus, Environnement (2000)

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See detailBase Plate in Bending and Anchor Bolts in Tension
Wald, Frantisek; Jaspart, Jean-Pierre ULg; sokol, Z et al

in Journal of Constructional Steel Research (2000)

The paper describes behaviour of the base plate in bending and the anchor bolts in tension, which is the major component of the base plate connection. The analytical model predicts the component ... [more ▼]

The paper describes behaviour of the base plate in bending and the anchor bolts in tension, which is the major component of the base plate connection. The analytical model predicts the component characteristics — the resistance and the stiffness. It is described how the quality of the behaviour is guided by the contact between the base plate and the concrete surface. The presented analytical prediction model is verified on tests and FE simulation. [less ▲]

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See detailL'écriture en actes.
Baye, Ariane ULg; Denooz, Régine; Vanhulle, Sabine

in Lettre de la DFLM (La) (2000), 26

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See detailNote sous Bruxelles, 23 septembre 1999
Thirion, Nicolas ULg

in Droit des Affaires : Revue Internationale du Droit des Affaires = Ondernemingsrecht : Internationaal Tijdschrift voor Ondernemingsrecht [= DA OR] (2000), 55

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See detailComparison of rectal and infrared ear temperatures in older hospital inpatients.
Smitz, Simon ULg; Giagoultsis, T; Dewé, Walthère ULg et al

in Journal of the American Geriatrics Society (2000), 48(1), 63-6

OBJECTIVES: To assess the agreement between infrared emission detection (IRED) ear and rectal temperatures and to determine the validity of IRED ear thermometry in detecting rectal fever. DESIGN ... [more ▼]

OBJECTIVES: To assess the agreement between infrared emission detection (IRED) ear and rectal temperatures and to determine the validity of IRED ear thermometry in detecting rectal fever. DESIGN: Prospective, convenience sample, unblinded study. SETTING: An acute geriatric unit (teaching hospital) and a multidisciplinary intensive care unit. PARTICIPANTS: The study included 45 inpatients (26 women and 19 men), aged 78.3+/-6.9 years, admitted over a 4-month period. Twelve of the patients were definitely infected. MEASUREMENTS: Sequential rectal (RT) and ear temperature (ET) measurements were performed using mercury-in-glass and IRED ear thermometers, respectively. IRED ear temperatures were measured at both ears (unadjusted mode), with the highest of six ear temperatures considered the true value. RESULTS: Mean RT (37.39 degrees C +/- 0.52 degrees C) was significantly (P<.001) higher than mean ET (36.89 degrees C +/-0.59 degrees C). A highly significant positive correlation was found between RT and ET (slope = 0.69; 95% CI, 0.52-0.86; P<.001; r = 0.78). The mean bias (mean of the differences) between RT and ET was 0.50 degrees C +/-0.37 degrees C (95% CI, 0.41 degrees C-0.59 degrees C), and the 95% limits of agreement -0.22 degrees C and 1.23 degrees C (95% CI, -0.38 degrees C to 1.39 degrees C). According to the standard criterion (RT > or =37.6 degrees C), 14 patients were febrile. Using an optimum IRED ear fever threshold (37.2 degrees C), the sensitivity and specificity of IRED ear thermometry for predicting rectal fever were 86% and 89%, respectively (positive predictive value, 80%; negative predictive value, 93%). CONCLUSIONS: The degree of agreement between rectal temperature and the highest of six IRED ear temperatures was acceptable. Using an optimal IRED ear fever threshold of 37.2 degrees C (99 degrees F), IRED ear thermometry had acceptable sensitivity and specificity for predicting rectal fever. [less ▲]

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See detailIncreased synovial fluid levels of interleukin-12, sCD25 and sTNF-RII/sTNF-RI ratio delineate a cytokine pattern characteristic of immune arthropathies
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in European Cytokine Network (2000), 11(4), 669-676

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different ... [more ▼]

The assessment of cytokines and their soluble receptors in the synovial fluid (SF) of inflammatory arthropathies may be useful in studying pathogenetic and immunoregulatory mechanisms underlying different diseases. The aim of this work was to study the cytokine network occurring in inflammatory arthropathies and to identify a cytokine profile which is characteristic of an immune-mediated synovitis. Levels of IL-12, as well as IL-4, IL-8, IL-10, IFN-gamma, sCD25, TNF-alpha and its soluble receptors were measured in the SF of various arthropathies, i.e. non-inflammatory arthropathies: "control" meniscus pathology (n = 21), osteoarthritis (n = 22) and chronic crystal arthritis (n = 9); a non-immune inflammatory arthropathy: acute crystal arthritis (n = 11); 2 immune inflammatory arthropathies: reactive arthritis (ReA) (n = 23) and rheumatoid arthritis (RA) (n = 44). SF levels of IL-10, TNF-alpha and sTNF-RII were found to be increased in the three inflammatory arthropathies compared to the "control" meniscus group. Within the inflammatory group, acute crystal arthritis was characterized by a significantly higher sTNF-RI/TNF-alpha ratio and ReA by a significantly lower sTNF-RII/TNF-alpha ratio compared to the two other diseases. The two immune arthropathies, RA and ReA, were characterized by increased SF levels of IL-12, sCD25 and of the sTNF-RII/sTNF-RI ratio. ReA differed however from RA by showing lower IL-8 and IL-4 levels, higher IFN-gamma levels and a higher IL-12/IL-10 ratio, suggesting a more prevalent Th1 profile in ReA SF. Our data indicate that the measurement of SF cytokines and soluble receptors may discriminate between each inflammatory arthropathy and might be useful in clinical practice. [less ▲]

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See detailDependency of Premature Ventricular Contractions on Heart Rate and Circadian Rhythms During Childhood
Massin, M. M.; Maeyns, K.; Withofs, Nadia ULg et al

in Cardiology (2000), 93(1-2), 70-3

The aim of the present study was to identify and quantify the rate dependence of premature ventricular contractions (PVC) during childhood. A 24-hour Holter recording was performed in 16 consecutive ... [more ▼]

The aim of the present study was to identify and quantify the rate dependence of premature ventricular contractions (PVC) during childhood. A 24-hour Holter recording was performed in 16 consecutive children, aged 22 days to 11 years (mean age 5.6 years), with frequent (>5,000/day), isolated monomorphic PVC. Those PVC were identified and the length of the preceding sinus cycle was measured. The values were ordered into 50-ms class intervals, and the percentage of PVC for each class was calculated and then analyzed by linear regression analysis. On the basis of the significance of the p value, and the positive or negative value of the slope, we identified a tachycardia-enhanced, a bradycardia-enhanced, and an indifferent pattern. Chronobiologic analysis was made by the cosinor method. All the patients had upper and lower limits of cycle length beyond which PVC disappeared. A tachycardia-enhanced pattern was present in 7 patients and an indifferent one in 9 patients. In the latter a second-degree polynomial correlation was systematically found. Children but not infants had a significant circadian variation in the frequency of PVC with a very variable time of highest incidence. In conclusion, it is possible to identify a circadian rhythm of PVC and a spontaneous trend between their incidence and the length of the preceding cardiac cycle in children. [less ▲]

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See detailWilson Harris Issue
Maes-Jelinek, Hena ULg

in Journal of Caribbean Literatures (2000), 2(1-2-3), 289

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See detailEffect of gonadal steroids on pituitary LH secretion and mediobasal hypothalamic GnRH mRNA in ferrets.
Bakker, Julie ULg; Baum, M. J.

in Journal of Reproduction and Fertility (2000), 119(2), 315-21

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the ... [more ▼]

In vitro release and content of GnRH in mediobasal hypothalamic slices are reduced by ovariectomy of female ferrets but are not affected by castration of male ferrets in breeding condition. The aim of the present study was to determine whether this sex difference reflects a sexually dimorphic effect of gonadal steroids on mediobasal hypothalamic GnRH mRNA content of male and female ferrets killed 4 weeks after gonadectomy, either with or without steroid hormone replacement. This time interval exceeds the 6-10 days needed for increments in plasma LH concentrations to stabilize after gonadectomy of ferrets of both sexes. In situ hybridization using an (35)S-labelled oligoprobe complementary to the human GnRH coding region showed that the number of mediobasal hypothalamic neurones and the cellular content of GnRH mRNA did not differ significantly among groups of male and female ferrets that were either in breeding condition or that had been gonadectomized and treated with sex steroids or oil vehicle. These results indicate that gonadal hormones regulate mediobasal hypothalamic GnRH biosynthesis and release in both sexes via post-transcriptional events that may include GnRH mRNA translation or the conversion of pre-pro GnRH precursor into mature GnRH. [less ▲]

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See detailSynovial fluid matrix metalloproteinase-3 levels are increased in inflammatory arthritides whether erosive or not
Ribbens, Clio ULg; Andre, Béatrice ULg; Kaye, O. et al

in Rheumatology (2000), 39(12), 1357-1365

OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether erosive or not, reactive arthritis, acute ... [more ▼]

OBJECTIVE: To study the levels of matrix metalloproteinase-3 (MMP-3) in the knee synovial fluid (SF) of inflammatory arthropathies (rheumatoid arthritis whether erosive or not, reactive arthritis, acute crystal arthritis) and degenerative arthropathies [chronic crystal disease, osteoarthritis and (control) meniscus pathology] and to correlate them with the degree of joint destruction, local inflammatory and immune parameters and systemic markers of inflammation. METHODS: SF levels of MMP-3 (precursor, active and tissue inhibitor of MMP-bound forms), tumour necrosis factor (TNF) alpha, soluble TNF receptors I and II, interleukin (IL)-6 and soluble IL-6 receptor were measured by ELISA in 107 inflammatory and 53 degenerative arthropathies. RESULTS: MMP-3 levels in SF were (i) significantly higher in inflammatory than in degenerative arthropathies; (ii) not related to the degree of joint destruction; (iii) significantly correlated with the levels of all SF markers tested and with erythrocyte sedimentation rate and serum levels of C-reactive protein and fibrinogen. CONCLUSION: Increased MMP-3 levels in SF are found in inflammatory arthropathies and are not specific for erosive joint diseases. MMP-3 in SF is therefore a potential candidate for the assessment of the inflammatory process in joints. However, the exclusive determination of the active form could indicate the degree of joint destruction. [less ▲]

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See detailMolecular diversity of Microcystis strains (Cyanophyceae, Chroococcales) based on 16S rDNA sequences
LEPERE, Claire ULg; Wilmotte, Annick ULg; Meyer, Barbara

in Systematics and Geography of Plants (2000), 70

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These ... [more ▼]

Partial 16S rDNA sequences were determined for six Microcystis strains from lakes in the region of Plön (Northern Germany) assigned to four different species on the basis of their morphology. These sequences appear very similar to each other and to those of 71 Microcystis strains from four continents available in the databases. This great genotypic homogeneity, as measured by 16S rDNA sequence similarity (334 characters), is contrasting with the conspicuous morphological differences observed for the studied strains. [less ▲]

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See detailAssessment of muscle oxygenation in the horse by near infrared spectroscopy
Pringle, John; Roberts, C.; Art, Tatiana ULg et al

in Equine Veterinary Journal (2000), 32(1), 59-64

This study examined the ability of near infrared spectroscopy (NIRS) to noninvasively determine changes to muscle oxygenation in the resting horse. Five horses had (NIRS) performed over extremity muscle ... [more ▼]

This study examined the ability of near infrared spectroscopy (NIRS) to noninvasively determine changes to muscle oxygenation in the resting horse. Five horses had (NIRS) performed over extremity muscle while under general anaesthesia, first with 8 min limb ischaemia, then systemic hypoxaemia for 5 min. A second group of 6 awake horses had NIRS performed over extremity muscle while being administered hypoxic gas (F(I)O2 0.10) for 5 min, and after return to steady state, limb ischaemia was induced for an additional 5 min. In the anaesthetised horses' ischaemia induced marked and significant muscle deoxygenation of haemoglobin/myoglobin (P<0.01), with corresponding arterial saturation decreasing from 98.9 to 81.9%. Hypoxaemia induced small yet significant muscle deoxygenation (P<0.01) that was 3.2% of the ischaemia deoxygenation signal, with a corresponding decrease in arterial saturation from 98.6 to 90.4%. In the awake horses muscle deoxygenation was not detectable during hypoxia despite reduction of arterial saturation from 97.8 to 86.8%, whereas ischaemia induced rapid and significant deoxygenation of muscle (P<0.05), with corresponding reduction of venous saturation from 78.4 to 75.4%. In neither group of horses was there evidence of cytochrome aa3 reduction, despite complete ischaemia for up to 8 min. NIRS changes in the resting horse muscle clearly differed between ischaemia and hypoxaemia, and can readily show muscle deoxygenation in clinically relevant hypoxaemia in the horse under anaesthesia. Further, as the deoxygenation signal induced by ischaemia was clearly detectable above a background movement artefact, NIRS application to study of muscle oxygenation in the working horse should be explored. [less ▲]

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See detailHipóteses estatísticas : revendo idéias sobre ortogonalidade e balanceamento em análise de varîancia
Iemma, Antonio Francisco; Claustriaux, Jean-Jacques ULg; Palm, Rodolphe ULg

in Multiciência (2000), 4(1), 62-82

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See detailSibling cannibalism in dorada under experimental conditions. I. Ontogeny, dynamics, bioenergetics of cannibalism and prey size selectivity
Baras, E.; Ndao, E.; Maxi, M. et al

in Journal of Fish Biology (2000), 57

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See detailLaparoscopic myolysis.
Donnez, Jacques; Sqifflet, Jean; Polet, Roland et al

in Human Reproduction Update (2000), 6(6), 609-13

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms ... [more ▼]

This review will focus on the different techniques and the long-term effects of the technique called myolysis on myoma growth. Indications for myolysis are essentially pelvic pain, compression symptoms and global uterine volume in order to avoid hysterectomy. In the late 1980s, myolysis was performed laparoscopically with the help of the neodynium: yttrium aluminium garnet (Nd:YAG) laser. Later, bipolar needles were developed as an alternative to the Nd:YAG laser. Diathermy and cryomyolysis were also proposed but series are small in the literature. Very recently, myoma interstitial thermo-therapy (MITT) was performed using the diode laser and a specific optical light diffuser that is designed to transmit laser light in all directions. Laparoscopic myolysis was proved to be effective in provoking myoma shrinkage, with a dramatic decrease in size and a marked devascularization of the myoma and this technique can be proposed as an alternative to myomectomy in selected patients: only those aged >40 years or those not desiring to bear any more children. [less ▲]

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See detailEspaces scolaires et violence
Born, Michel ULg

in PEB Echanges (2000)

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See detailLuxation traumatique du tendon du tibialis posterior.
Kakanou, A.; Liloku, R.; NCHIMI LONGANG, Alain ULg et al

in Acta Orthopaedica Belgica (2000), 66(5), 514-6

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical ... [more ▼]

Anterior dislocation of the tibialis posterior tendon is a traumatic lesion, which is rarely suspected following ankle trauma. It seems to be promoted by hypoplasia of the retromalleolar sulcus. Surgical treatment is easy and reportedly gives excellent results, but the diagnosis is difficult and absence of diagnosis may result in functional instability of the foot requiring more invasive surgical treatment. [less ▲]

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See detailClinical and para-clinical tests in the routine examination of headache patients.
Friberg, L.; Sandrini, G.; Janig, W. et al

in Functional Neurology (2000), 15 Suppl 3

Para-clinical examinations in the diagnosis and treatment control of headache patients vary considerably between clinics and headache centers. Among the neurological societies in Europe there has been a ... [more ▼]

Para-clinical examinations in the diagnosis and treatment control of headache patients vary considerably between clinics and headache centers. Among the neurological societies in Europe there has been a consensus that some common procedures and recommendations should be created. In the Fall of 1998, the European Federation of Neurological Societies (EFNS) commissioned a Task Force on Neurophysiological Tests and Imaging Procedures in Headache Patients. Members of the Task Force are the present authors and we have reviewed the literature on 1) neurophysiological tests (EEG and evoked potentials), 2) autonomic nervous system and clinical tests and 3) imaging and cerebrovascular tests (X-ray, CT, MR, fMRI, PET, SPECT and transcranial Doppler). The literature was carefully evaluated with respect to validity and strength of the data. The task was to reach conclusions about each technique in the form of guidelines for clinical use. Finally, selected areas for future research will be outlined. The extensive review and the guidelines will be published by the EFNS during 2000. [less ▲]

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See detailCongestion Control for Layered Multicast Transmission
El Khayat, Ibtissam; Leduc, Guy ULg

in Networking and Information Systems Journal (2000), 3(3-4), 559-573

Heterogeneity of receivers makes it hard to control congestion for multicast transmission. Using hierarchical layering of the information is one of the most elegant and efficient approach to tackle this ... [more ▼]

Heterogeneity of receivers makes it hard to control congestion for multicast transmission. Using hierarchical layering of the information is one of the most elegant and efficient approach to tackle this problem. The proposed algorithm is based on this principle and has three objectives: to fulfill intra-session fairness, i.e. between different receivers of the same session; to be fair towards TCP; to fulfill inter-session fairness, i.e. same throughputs (and not number of layers) to concurrent sessions. [less ▲]

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See detailLifetimes of metastable state in Sr II
Biémont, Emile ULg; Lidberg, J.; Mannervik, S. et al

in European Physical Journal D -- Atoms, Molecules, Clusters & Optical Physics (2000), 11

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See detailHabituation of visual and intensity dependence of auditory evoked cortical potentials tends to normalize just before and during the migraine attack.
Judit, A.; Sandor, P. S.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (2000), 20(8), 714-9

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked ... [more ▼]

Between attacks, migraine with (MO) or without aura (MA) patients show deficient habituation of pattern-reversal visual evoked potentials (PR-VEP) and a strong intensity dependence of auditory evoked cortical potentials (IDAP). Clinical observations of migraine prodromes and previously published electrophysiological studies suggest that cortical information processing may vary in close temporal relationship to the attack. We studied PR-VEP and IDAP just before (11 MO pts), during (23 MO, 3 MA), 1 day following (27 MO, 1 MA) and 2 days following (14 MO) a migraine attack. The results were compared with a large group of MO patients recorded at a distance of at least 3 days from an attack (n = 66 for IDAP; n = 39 for VEP). Patients recorded the day before the attack had on average an habituation of -13.6+/-20.5% (mean +/- SD) between the 5th and 1st block of 100 averaged VEP responses and a flat (0.38+/-1.06 microV/10 dB) amplitude-stimulus intensity function (ASF) slope of the auditory evoked cortical potential. Both values were significantly different from those obtained in the attack interval (P=0.003; P=0.020). During the attack, VEP habituation was less pronounced (-0.17+/-26.2%) and ASF slopes remained flat (0.32+/-1.44 microV/10 dB; P=0.002 compared to interval). During the 2 days following the attack, VEP habituation was replaced by potentiation (+0.09+/-29.1% the 1st day; 19.5+/-45.7% the 2nd day) and ASF slopes increased markedly (0.87+/-1.39 and 1.14+/-1.12 microV/10 dB). The normalization of evoked cortical responses just before and during the attack, might reflect an increase in the cortical preactivation level due to enhanced activity in raphe-cortical serotonergic pathways. [less ▲]

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See detailComment j'explore ... un cancer broncho-pulmonaire par imagerie metabolique (TEP-18-FDG).
Bury, Thierry ULg; DUYSINX, Bernard ULg; CORHAY, Jean-Louis ULg et al

in Revue Médicale de Liège (2000), 55(3), 178-83

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that ... [more ▼]

Continuing advances in PET imaging have resulted in an improved ability to evaluate thoracic malignancies. Published reports demonstrate that PET provides accurate noninvasive detection of malignancy that is useful in the characterization of a pulmonary solitary nodule and in the mediastinal or extrathoracic staging of known lung cancer. Preliminary studies suggest that PET may also be able to assess the therapeutic response after surgery or radiation therapy. [less ▲]

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See detailRythmes du temps: de l'Astronomie à l'Histoire
Biémont, Emile ULg

in Ciel et Terre (2000), 116(3), 72-81

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See detailZwitterionic (pyrrolidine-2,2-diyl)bisphosphonic acid at 100, 150 and 293K
Olive, Gilles ULg; Ellis, Dianne D; Siri, Didier et al

in Acta Crystallographica Section C-Crystal Structure Communications (2000), C56(6), 720-722

Structure of the zwitterionic pyrrolidine-2,2-diylbis(phosphonic acid) at 100, 150 and 293 K

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See detailSystemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis.
Pardutz, A.; Krizbai, I.; Multon, Sylvie ULg et al

in Neuroreport (2000), 11(14), 3071-5

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of ... [more ▼]

Systemic administration of nitroglycerin, a nitric oxide donor, triggers in migraineurs a delayed attack of unknown mechanisms. Subcutaneous nitroglycerin (10 mg/kg) produced a significant increase of nitric oxide synthase (NOS)- and c-fos-immunoreactive neurons in the cervical part of trigeminal nucleus caudalis in rats after 4 h. This effect was not observed in the thoracic dorsal horn. Similar increase of NOS and c-fos was obtained in the brain stem after a somatic nociceptive stimulus, i.e. on the side of the formalin injection in the lip. Nitric oxide is thus able to increase NOS availability in second order nociceptive trigeminal neurons, which may be relevant for central sensitization and the understanding of its effect in migraine. [less ▲]

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See detailPour une démarche de qualité dans la formation continuée des enseignants : rôle de l'évaluation
Giot, Bernadette ULg

in Point sur la Recherche en Education (Le) (2000), 21

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See detailOn a q-analogue of the spin-orbit coupling
Micu, M.; Stancu, Floarea ULg

in Journal of Physics : A Mathematical & General (2000), A33

Based on the tensor method, a $q$-analogue of the spin-orbit coupling is introduced in a $q$-deformed Schr\" odinger equation, previously derived for a central potential. Analytic expressions for the ... [more ▼]

Based on the tensor method, a $q$-analogue of the spin-orbit coupling is introduced in a $q$-deformed Schr\" odinger equation, previously derived for a central potential. Analytic expressions for the matrix elements of the representations $j = \ell \pm 1/2$ are derived. The spectra of the harmonic oscillator and the Coulomb potential are calculated numerically as a function of the deformation parameter, without and with the spin-orbit coupling. The harmonic oscillator spectrum presents strong analogies with the bound spectrum of an Woods-Saxon potential customarily used in nuclear physics. The Coulomb spectrum simulates relativistic effects. The addition of the spin-orbit coupling reinforces this picture. [less ▲]

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See detailL'artériopathie des membres inférieurs chez la personne âgée
Petermans, Jean ULg; Zicot, M.

in Angéiologie (2000), 52(1), 13-17

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See detailDe l'archétype savant au stéréotype politique : figures médiatiques du leader ouvrier
Geuens, Geoffrey ULg

in Quaderni : la Revue de la Communication (2000), 40 ("Utopie I : la fabrique de l'utopie")(Hiver 1999-2000), 53-67

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See detailPrivatisation d'entreprises publiques, économie de marché et transformation des systèmes juridiques étatiques
Thirion, Nicolas ULg

in Pyramides : Revue du Laboratoire d’Etudes et de Recherches en Administration Publique (2000), (2), 85-110

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See detailAffections cardiaques et intolérances à l'effort. 1-Les troubles du rythme.
Amory, Hélène ULg; Art, Tatiana ULg

in Pratique Vétérinaire Equine (2000), 32(Numéro Spécial), 71-78

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See detailRandomized comparison of intranasal and transdermal estradiol.
Lopes, P.; Merkus, H. M.; Nauman, J. et al

in Obstetrics & Gynecology (2000), 96(6), 906-12

To compare the efficacy and patient acceptability of intranasal versus transdermal 17 beta-estradiol (E2) delivery systems for postmenopausal symptoms. METHODS: Postmenopausal women were randomly assigned ... [more ▼]

To compare the efficacy and patient acceptability of intranasal versus transdermal 17 beta-estradiol (E2) delivery systems for postmenopausal symptoms. METHODS: Postmenopausal women were randomly assigned to intranasal 17 beta-E2, 300 microg daily (n = 176) or transdermal 17 beta-E2 (delivering 50 microg/day), two patches per week (n = 185) for 12 weeks, followed by a 4-week period with the alternate treatment. Efficacy was compared between groups using the Kupperman Index and vasomotor symptoms at week 12. Patient acceptability was compared by patient choice of administration route and by questionnaire at week 16. RESULTS: Intranasal and transdermal therapy produced significant reductions in the Kupperman Index and in the occurrence of hot flushes and night sweats at week 12. Alleviation of climacteric symptoms was statistically equivalent in the two treatment groups (P <.001). The difference between groups in the Kupperman Index score of -0.5 +/- 0.9 (95% confidence interval -2.3, 1.3) was within the predetermined interval of equivalence. Both therapies were well tolerated with similar adverse event rates, except for moderate and severe mastalgia which was significantly less frequent with intranasal E2 (7.2%) than with the patch (15.5%, P =.02). Sixty-six percent of patients chose to continue the intranasal therapy and 34% the transdermal therapy (P <.001). Satisfaction was greater with intranasal therapy at week 16 (P <.001). CONCLUSION: Intranasal and transdermal estrogen delivery systems had equivalent efficacy and similar safety profiles. Intranasal therapy was the patients' choice for long-term treatment. [less ▲]

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See detailAerosol therapy in veterinary medicine : is it the future ?
Lekeux, Pierre ULg

in Veterinary Journal (2000), 160

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See detailTransplantation of cultured explants of human endometrium into nude mice
NISOLLE, Michelle ULg; Casanas-Roux, Françoise; Marbaix, Etienne et al

in Human Reproduction (2000), 15(3), 572-7

The objective of this study was to analyse the histological and immunohistochemical characteristics of cultured explants of human endometrium transplanted into nude mice. Biopsies of eutopic endometrium ... [more ▼]

The objective of this study was to analyse the histological and immunohistochemical characteristics of cultured explants of human endometrium transplanted into nude mice. Biopsies of eutopic endometrium were taken from six patients during laparoscopic surgery and classified according to the phase of the cycle. All the explants were cultured with oestrogen and progesterone for 24 h before transplantation into 15 mice. Four mice were grafted with explants of menstrual endometrium, four with explants of late proliferative endometrium, and seven with explants of late secretory-premenstrual endometrium. Typical endometrial glands and stroma were observed in 87% of cases 3 weeks after the transplantation. All the grafts revealed histological characteristics of the proliferative phase, even when the endometrial biopsy was taken during the late secretory phase. Immunohistochemical studies revealed that the proliferation index was high, whatever the menstrual phase of the endometrial biopsy. An extensive vascular network developed at the interface between the graft and the surrounding tissue. Vascular endothelial growth factor (VEGF) positive stained cells were observed in all grafts, the VEGF score being significantly higher in epithelial cells than in stromal cells. In conclusion, human endometrial explants, cultured for 24 h, could be successfully transplanted into nude mice. Immunohistochemical studies proved that human cultured endometrial tissue could not only survive in nude mice but could also become very active and develop characteristics different from the tissue of origin. An active vascular network is a necessary condition for the survival of the graft and may be explained by the high VEGF content. [less ▲]

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See detailLa Convention de Bruxelles
Boularbah, Hakim ULg; Nuyts, Arnaud; Watte, N.

in Journal des Tribunaux Droit Européen (2000)

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See detailA new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi.
Bompard-Gilles, C; Villeret, V; Davies, G J et al

in Structure (2000), 8(2), 153-62

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate ... [more ▼]

BACKGROUND: The L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi (DmpA) releases the N-terminal L and/or D-Ala residues from peptide substrates. This is the only known enzyme to liberate N-terminal amino acids with both D and L stereospecificity. The DmpA active form is an alphabeta heterodimer, which results from a putative autocatalytic cleavage of an inactive precursor polypeptide. RESULTS: The crystal structure of the enzyme has been determined to 1.82 A resolution using the multiple isomorphous replacement method. The heterodimer folds into a single domain organised as an alphabetabetaalpha sandwich in which two mixed beta sheets are flanked on both sides by two alpha helices. CONCLUSIONS: DmpA shows no similarity to other known aminopeptidases in either fold or catalytic mechanism, and thus represents the first example of a novel family of aminopeptidases. The protein fold of DmpA does, however, show structural homology to members of the N-terminal nucleophile (Ntn) hydrolase superfamily. DmpA presents functionally equivalent residues in the catalytic centre when compared with other Ntn hydrolases, and is therefore likely to use the same catalytic mechanism. In spite of this homology, the direction and connectivity of the secondary structure elements differ significantly from the consensus Ntn hydrolase topology. The DmpA structure thus characterises a new subfamily, but supports the common catalytic mechanism for these enzymes suggesting an evolutionary relationship. [less ▲]

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See detailErgotamine in the acute treatment of migraine: a review and European consensus.
Tfelt-Hansen, P.; Saxena, P. R.; Dahlof, C. et al

in Brain : A Journal of Neurology (2000), 123 ( Pt 1)

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe ... [more ▼]

Ergotamine has been used in clinical practice for the acute treatment of migraine for over 50 years, but there has been little agreement on its place in clinical practice. An expert group from Europe reviewed the pre-clinical and clinical data on ergotamine as it relates to the treatment of migraine. From this review, specific suggestions for the patient groups and appropriate use of ergotamine have been agreed. In essence, ergotamine, from a medical perspective, is the drug of choice in a limited number of migraine sufferers who have infrequent or long duration headaches and are likely to comply with dosing restrictions. For most migraine sufferers requiring a specific anti-migraine treatment, a triptan is generally a better option from both an efficacy and side-effect perspective. [less ▲]

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See detailPost-stroke reorganization of hand motor area: a 1 year longitudinal study with focal transcranial magnetic stimulation.
DELVAUX, Valérie ULg; ALAGONA G.; DE PASQUA, Victor ULg et al

in Clinical Neurophysiology (2000), 111(Suppl. 1), 12517-06

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See detailLimited effects of placental and pituitary growth hormone on cytokine expression in vitro
Thellin, Olivier ULg; Coumans, Bernard ULg; Devos, Sébastien ULg et al

in European Cytokine Network (2000), 11(3), 452-455

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked ... [more ▼]

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked immunosorbent assay (ELISA) and ribonuclease protection assay, and in tonsillar cells by ELISA. In addition to pituitary GH (GH-N), the placental form (GH-V), differing from pituitary GH by 13 amino acids has also been tested. Only few effects reached statistical significance and were in no case greater than 15%. Pituitary GH slightly reduced IL-5 production and stimulated IFN-gamma production. The latter effect was also observed with prolactin and could thus be induced through the prolactin receptor. It is proposed that GH has no strong effects on the parameters investigated, possibly as a result of redundancy in the cytokine network. Alternatively, effects on leukocytes are mediated by other tissues such as the liver or are clear only in response to stronger challenges. [less ▲]

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See detailPhalangeal osteosonogrammetry study: age-related changes, diagnostic sensitivity, and discrimination power. The Phalangeal Osteosonogrammetry Study Group.
Wuster, C; Albanese, C; De Aloysio, D et al

in Journal of Bone and Mineral Research (2000), 15(8), 1603-14

Phalangeal osteosonogrammetry was introduced as a method for bone tissue investigation in 1992. It is based on the measure of the velocity of ultrasound (amplitude-dependent speed of sound [AD-SoS]) and ... [more ▼]

Phalangeal osteosonogrammetry was introduced as a method for bone tissue investigation in 1992. It is based on the measure of the velocity of ultrasound (amplitude-dependent speed of sound [AD-SoS]) and on the interpretation of the characteristics of the ultrasound signal. In this study we have collected a database of 10,115 subjects to evaluate the performance of AD-SoS and to develop a parameter that is able to quantify the signal characteristics: ultrasound bone profile index (UBPI). The database only includes females of which 4.5% had documented vertebral osteoporotic fractures, 16% lumbar spine dual X-ray absorptiometry (DXA), and 6% hip DXA. The analysis of the ultrasound signal has shown that with aging the UBPI, first wave amplitude (FWA), and signal dynamics (SDy) follow a trend that is different from the one observed for AD-SoS; that is, there is no increase during childhood. In the whole population, the risk of fracture per SD decrease for AD-SOS was odds ratio (OR) 1.71 (CI, 1.58-1.84). The AD-SoS in fractured subjects was significantly lower than in a group of age-matched nonfractured subjects (p < 0.0001). In a small cohort of hip-fractured patients UBPI proved to be lower than in a control age-matched group (p < 0.0001). When the World Health Organization (WHO) working group criteria were applied to this population to identify the T score value for osteoporosis, for AD-SoS we found a T score of -3.2 and for UBPI we found a T score of -3.14. Sixty-six percent of vertebral fractures were below the AD-SoS -3.2 T score and 62% were below UBPI -3.14. We observed the highest incidence of fractures (63.6%) among subjects with AD-SoS who had both DXA T score values below the threshold. We conclude from this study that ultrasound investigation at the hand phalanges is a valid methodology for osteoporosis assessment. It has been possible to quantify signal changes by means of UBPI, a parameter that will improve the possibility of investigating bone structure. [less ▲]

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See detailLandscape fragmentation assessment using a single measure.
Bogaert, Jan ULg; Van Hecke, P; Salvador-Van Eysenrode, D et al

in Wildlife Society Bulletin (2000), 28(4), 875-881

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See detailEffect of Temperature on Growth of Psychrophilic and Psychrotrophic Members of Rhodotorula Aurantiaca
Sabri, Ahmed ULg; Jacques, Philippe ULg; Weekers, Frederic et al

in Applied Biochemistry and Biotechnology (2000), 84-86(Spring), 391-9

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium ... [more ▼]

The thermo-dependence of growth kinetic parameters was investigated for the Antarctic psychrophilic strain Rhodotorula aurantiaca and a psychrotrophic strain of the same species isolated in Belgium (Ardennes area). Cell production, maximum growth rate (mu max), and half-saturation constant for glucose uptake (Ks) of both yeasts were temperature dependent. For the two yeasts, a maximum cell production was observed at about 0 degree C, and cell production decreased when temperature increased. The mu max values for both strains increased with temperature up to a maximum of 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. For both yeasts, Ks for glucose was relatively constant at low temperatures. It increased at temperatures above 10 degrees C for the psychrophilic strain and 17 degrees C for the psychrotrophic strain. Although its glucose affinity was lower, the psychrotrophic strain grew more rapidly than the psychrophilic one. The difference in growth rate and substrate affinity was related to the origin of the strain and the adaptation strategy of R. aurantiaca to environmental conditions. [less ▲]

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See detailRelationship between CNV topography and irritability in depression
Papart, Patrick ULg; WEERTS, Pascale ULg; Pinto, Emmanuel ULg et al

in Journal of Psychophysiology (2000), 14(Suppl 1),

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See detailDe la relation spatiale entre les personnages des groupes statuaires royaux en Égypte pharaonique
Laboury, Dimitri ULg

in Revue d'Egyptologie (2000), 51

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional ... [more ▼]

Given the unity of representational system of Ancient Egypt, the author proposes to investigate the possibility of application of the principle of the "rabattement" or folding back in a three-dimensional art such as statuary, considering the case of the royal statue groups [less ▲]

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See detailClinical Usefulness of the Mini Nutritional Assessment (Mna) Scale in Geriatric Medicine
Gazzotti, C.; Albert, Adelin ULg; Pepinster, A. et al

in Journal of Nutrition, Health & Aging (The) (2000), 4(3), 176-81

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized ... [more ▼]

OBJECTIVE: This study was undertaken to estimate the prevalence of malnutrition in elderly patients hospitalized with an acute illness, as well as to assess the clinical usefulness of standardized nutritional assessment upon admission by means of the MNA scale. Design: A prospective study. Setting: A large size regional university hospital. Subjects: There were 175 patients (113 women and 62 men) with a mean age of 79.7 + 8.5 years admitted for an acute problem. Death occurred in 11 patients (6.3%). METHODS: Upon admission, demographic (age, gender, origin) and medical (disease, drugs) data were recorded for each patient; the MNA questionnaire (score: 0-30) was administered and Katz score (7-28) calculated. At hospital discharge, data included Katz score, outcome (death/survival), and destination. RESULTS: The mean MNA score was 20.5 + 5.1 and the prevalence of severe malnutrition (MNA <17) was 21.7%. Further, 48.6% of elderly were at risk of malnutrition (MNA between 17 and 24). There was no association between MNA and age or gender, but underweight was a sign of low MNA values (P <.001). MNA scores were inversely related to Katz scores at both admission and hospital discharge (P <.001). Patients originating from nursing homes had a poorer nutritional status than those living at home (MNA: 18.4 against 22.3, P <.001). The number of drugs taken per patient (5.2 + 2.8) was found to be correlated with MNA (P =.049). MNA scores were on average significantly higher (P <.001) in survivors (20.9) than in nonsurvivors (14.1). CONCLUSIONS: The study clearly demonstrates the high prevalence of malnutrition and the clinical usefulness of the MNA scale in geriatric medicine. The MNA score upon admission reflects the patient's nutritional condition, degree of autonomy (Katz score), living conditions and current treatment. It is also predictive of patient's outcome (death or survival). [less ▲]

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See detailIpsilateral motor responses to focal transcranial magnetic stimulation in normal and stroke patients.
ALAGONA G.; DELVAUX, Valérie ULg; GERARD, Pascale ULg et al

in Journal of Neurology, Neurosurgery & Psychiatry (2000), Neurosurgery and Psychiatry

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See detailBladder endometriosis must be considered as bladder adenomyosis
Donnez, Jacques; Spada, Francesca; Squifflet, Jean et al

in Fertility and Sterility (2000), 74(6), 1175-1181

Objective: To present data from a series of 17 cases of bladder endometriosis. Design: Clinical study. Setting: A university hospital department of gynecology. Patient(s): Seventeen patients complaining ... [more ▼]

Objective: To present data from a series of 17 cases of bladder endometriosis. Design: Clinical study. Setting: A university hospital department of gynecology. Patient(s): Seventeen patients complaining of menstrual urinary symptoms and/or pelvic pain. Intervention(s): Diagnosis and resection of a bladder adenomyotic nodule. Main Outcome Measure(s): Histologic analysis and postsurgical outcome. Result(s): Seventy-six percent of the patients reported menstrual mictalgia and pollakiuria, and 88% reported dysmenorrhea and dyspareunia. Cystoscopy, intravenous pyelography, and magnetic resonance imaging revealed a nodular mass in the anterior fornix adjacent to the uterine wall, developed in the vesical muscularis and involving the vesical mucosa in all cases but one. The bladder nodule was associated with a rectovaginal nodule in six cases (35%). Because recurrence was noted soon after cessation of medical therapy, surgical excision was proposed. The vesical mucosa was found to be intact in almost all cases, so extramucosal laparoscopic excision was the method of choice. Histologic examination proved that 90% of the nodule consisted of smooth muscle hyperplasia. Conclusion(s): So-called bladder endometriosis is actually an adenomyotic nodule of the bladder which, from a histologic point of view, is similar to a rectovaginal adenomyotic nodule and frequently (35%) associated with it. [less ▲]

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See detailAspects physiologiques de la sécrétion laitière par la mamelle bovine
Dosogne, H; Arendt, J; Gabriel, Annick ULg et al

in Annales de Médecine Vétérinaire (2000), 144

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See detailA propos du nom de l'interprète en latin
Rochette, Bruno ULg

in Glotta : Zeitschrift für Griechische und Lateinische Sprache (2000), 76

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See detailDe Don Quichotte à Michel Siffre : explorations du temps psychologique
Richelle, Marc ULg

in Bulletin de la Classe des Lettres (2000), 6e série, tome XI(7-12), 467-490

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See detailCurrent and future trends in groundwater vulnerability assessment
Gogu, Radu; Dassargues, Alain ULg

in Environmental Geology (2000), 39(6), 549-559

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have ... [more ▼]

The concept of groundwater vulnerability is a useful tool for environmental planning and decision-making. Many different methods have been developed for assessing this vulnerability. Hydrogeologists have failed to reach a consensus concerning the definitions of and reference terms for groundwater vulnerability assessment. Therefore, a review of vulnerability assessment and mapping methods providing a new classification system is necessary. This is focused on techniques that use the overlay and index class methods. New research challenges in vulnerability assessment are identified, especially the need for developing dynamic links between numerical models and overlay and index methods. [less ▲]

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See detailObservations sous Cass., 11 février 2000
Boularbah, Hakim ULg

in Revue de Droit Judiciaire et de la Preuve = Tijdschrift voor Procesrecht en Bewijsrecht (2000)

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See detailDu chêne au tonneau
Jourez, Benoît ULg; Quin, Jean-Philippe

in Courrier du Bois (2000), 129

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les ... [more ▼]

La tonnellerie, activité à la fois artisanale et industrielle, tire profit des plus beaux chênes. Si le mode de fabrication traditionnel du tonneau n'a pratiquement pas changé depuis son invention par les Celtes il y a plus de 2000 ans, certains développements technologiques sont venus aider les artisans dans leur travail quotidien. Parallèlement, le progrès des connaissances dans les sciences du bois, de la chimie et de la microbiologie nous ont appris à quel point l'élevage du vin en fûts de chêne reste une étape essentielle dans la maturation de ce liquide sacré. [less ▲]

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See detailHet botkapitaal : een spaarboekje dat in de wieg begint
Halkin, V; Reginster, Jean-Yves ULg

in De Agenda Pediatrie (2000), 22

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See detailBiotransformation of ricinoleic acid into g-decalactone by yeast cells: recent progress and current questions
Aguedo, Mario ULg; Waché, Yves; Belin, J.M.

in Recent Research Developments in Biotechnology & Bioengineering (2000), 3

Lactone aroma compounds production can be achieved biotechnologically by microbial fermentation and notably using yeasts. Many studies have been carried out to understand the mechanisms implicated in such ... [more ▼]

Lactone aroma compounds production can be achieved biotechnologically by microbial fermentation and notably using yeasts. Many studies have been carried out to understand the mechanisms implicated in such bioreactions, and a pathway involving peroxisomal β-oxidation was established but some unelucidated points remain. In the recent years, new developments appeared proposing biotechnological ways to overcome and understand lactone toxicity or its commonly observed reconsumption and trying to explain some confused points like fatty acid emulsification, entry and storage into the cell. The importance of acyl-CoA oxidases in the metabolic pathway implicated and thus in the lactone production as well as on its reconsumption was also focused. Simultaneously with a presentation of the biotransformation pathways, these points are discussed in the light of new data including not yet published data obtained mainly with the yeast Yarrowia lipolytica. [less ▲]

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See detailEvaluation of EMIT tox benzodiazepine and barbiturate assays on the Vitalab Viva analyser and FPIA on the Abbott ADx analyser
Charlier, Corinne ULg; Plomteux, Guy ULg

in Clinical Chemistry & Laboratory Medicine (2000), 38(7), 615-618

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in ... [more ▼]

We evaluated the performance of the Emit® tox benzodiazepine and barbiturate assays (Dade Behring) and fluorescence polarisation immunoassay (FPIA) (Abbott) for use with serum determinations in preliminary therapeutic drug monitoring or acute drug intoxication detection. Performance, as indicated by CVs, of the Emit® tox benzodiazepine and barbiturate assays and FPIA showed that both immunochemical techniques are precise and have good reproducibility. For within-run studies, results from benzodiazepine determinations showed maximum CV values of 1.91% for the Emit® method and 2.65% for FPIA; results from barbiturate determinations showed maximum CV values of 2.01% for the Emit® method and 1.89% for FPIA. For between-run studies, results from benzodiazepine determinations showed maximum CV values of 1.79% for the Emit® method and 1.12% for FPIA; results from barbiturate determinations showed maximum CV values of 2.09% for the Emit® method and 2.02% for FPIA. [less ▲]

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See detailInfluence of ventilatory pattern on respiratory impedance measured by impulse oscillometry in horses
Van Erck, Emmanuelle ULg; Kirschvink, Nathalie; Art, Tatiana ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440(R219-R220),

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See detailConstruction and characterization of an ovine BAC contig spanning the callipyge locus.
SEGERS, Karin ULg; Vaiman, D.; Berghmans, S. et al

in Animal Genetics (2000), 31(6), 352-9

We describe the construction of an ovine BAC contig spanning a 4.6 centimorgan (cM) chromosome segment known to contain the callipyge (CLPG) locus. The contig comprises 21 ovine BAC clones jointly ... [more ▼]

We describe the construction of an ovine BAC contig spanning a 4.6 centimorgan (cM) chromosome segment known to contain the callipyge (CLPG) locus. The contig comprises 21 ovine BAC clones jointly covering approximately 900 kilobases (Kb). Two gaps in the BAC contig, spanning 10 and 7.5 Kb, respectively, were bridged by long range PCR. The corresponding chromosome region was shown to be characterized by an unusually low Kb to cM ratio (164 Kb/cM) and a high density of Not1 sites (1:126 Kb) possibly reflecting a high gene density in the corresponding chromosome region. Equivalent amplification of 64 sequence tagged sites spanning the corresponding region from homozygous +/+ and CLPG/CLPG individuals disproves the hypothesis of a major deletion causing the CLPG mutation. [less ▲]

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See detailL'osteoporose involutive de la femme: strategie therapeutique. Un point de vue actualise du Belgian Bone Club.
Kaufman, J M; Body, J J; Boonen, S et al

in Revue Médicale de Liège (2000), 55(5), 443-8

Osteoporosis is now considered as a major public health issue and a serious threat for the quality of life of elderly women. Several new compounds are currently marketed for the prevention and treatment ... [more ▼]

Osteoporosis is now considered as a major public health issue and a serious threat for the quality of life of elderly women. Several new compounds are currently marketed for the prevention and treatment of involutional osteoporosis in women. Therefore, it is important to offer to the practitioners pragmatic solutions to be used for the rational management of this disorder. This article is the result of a national consensus offering practical guidelines for the management of osteoporotic patients, based on the current published data. [less ▲]

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See detailLe financement public des cultes, de la laïcité et des cours philosophiques
Husson, Jean-François ULg

in Courrier Hebdomadaire du CRISP (2000), (1703-1704), 3-90

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described ... [more ▼]

This publication details all channels through which religious and philosophical communities in Belgium are financed by local, regional or federal governments. Institutional environment is described. Detailed budgetary data are provided and are set in perspective with sociological data on religious practices or belonging. [less ▲]

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See detailPreventie van postmenopauzale osteoporose
Reginster, Jean-Yves ULg; Halkin, V

in De agenda Gynaecologie (2000), 19

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See detailAuditory steady-state response and bispectral index for assessing level of consciousness during propofol sedation and hypnosis.
Bonhomme, Vincent ULg; Plourde, Gilles; Meuret, Pascal et al

in Anesthesia and analgesia (2000), 91(6), 1398-403

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects ... [more ▼]

We assessed the effect of propofol on the auditory steady-state response (ASSR), bispectral (BIS) index, and level of consciousness in two experiments. In Experiment 1, propofol was infused in 11 subjects to obtain effect-site concentrations of 1, 2, 3, and 4 microg/mL. The ASSR and BIS index were recorded during baseline and at each concentration. The ASSR was evoked by monaural stimuli. Propofol caused a concentration-dependent decrease of the ASSR and BIS index values (r(2) = 0.76 and 0.93, respectively; P<0.0001). The prediction probability for loss of consciousness was 0.89, 0.96, and 0.94 for ASSR, BIS, and arterial blood concentration of propofol, respectively. In Experiment 2, we compared the effects of binaural versus monaural stimulus delivery on the ASSR in six subjects during awake baseline and propofol-induced unconsciousness. During baseline, the ASSR amplitude with binaural stimulation (0.47+/-0.13 microV, mean +/- SD) was significantly (P<0.002) larger than with monaural stimulation (0.35+/-0.11 microV). During unconsciousness, the amplitude was 0.09+/-0.09 microV with monaural and 0.06+/-0.04 microV with binaural stimulation (NS). The prediction probability for loss of consciousness was 0.97 (0.04 SE) for monaural and 1.00 (0.00 SE) for binaural delivery. We conclude that the ASSR and BIS index are attenuated in a concentration-dependent manner by propofol and provide a useful measure of its sedative and hypnotic effect. BIS was easier to use and slightly more sensitive. The ASSR should be recorded with binaural stimulation. The ASSR and BIS index are both useful for assessing the level of consciousness during sedation and hypnosis with propofol. However, the BIS index was simpler to use and provided a more sensitive measure of sedation. IMPLICATIONS: We have compared two methods for predicting whether the amount of propofol given to a human subject is sufficient to cause unconsciousness, defined as failure to respond to a simple verbal command. The two methods studied are the auditory steady-state response, which measures the electrical response of the brain to sound, and the bispectral index, which is a number derived from the electroencephalogram. The results showed that both methods are very good predictors of the level of consciousness; however, bispectral was easier to use. [less ▲]

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See detailRenal Artery Occlusion Following Blunt Abdominal Trauma
Elen, Philippe ULg; Ozlu, E.; SakalihasanN, Natzi ULg et al

in Acta Chirurgica Belgica (2000), 100(3, May-Jun), 107-10

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See detailLaser-induced transitions between triply excited hollow states
Madsen, L. B.; Schlagheck, Peter ULg; Lambropoulos, P.

in Physical Review. A (2000), 62(6), 062719

Using complex scaling and a correlated basis constructed in terms of B splines, we calculate the Li+ photoion yield in the presence of a laser-induced coupling between the triply excited 2s(2)2p(P-2(0 ... [more ▼]

Using complex scaling and a correlated basis constructed in terms of B splines, we calculate the Li+ photoion yield in the presence of a laser-induced coupling between the triply excited 2s(2)2p(P-2(0)) and 2s2p(2)(D-2(e)) resonances in lithium, the first of which is assumed to be excited by synchrotron radiation from the ground state. The laser coupling between the triply excited states is shown to lead to a significant and readily measurable modification of the line profile which provides a unique probe of the dipole strength between highly correlated triply excited states. We also present results for some higher-lying triply excited states of P-2(0) symmetry. [less ▲]

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See detailCrystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.
Concha, N. O.; Janson, C. A.; Rowling, P. et al

in Biochemistry (2000), 39(15), 4288-98

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there ... [more ▼]

Metallo beta-lactamase enzymes confer antibiotic resistance to bacteria by catalyzing the hydrolysis of beta-lactam antibiotics. This relatively new form of resistance is spreading unchallenged as there is a current lack of potent and selective inhibitors of metallo beta-lactamases. Reported here are the crystal structures of the native IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor, 2-[5-(1-tetrazolylmethyl)thien-3-yl]-N-[2-(mercaptomethyl)-4 -(phenylb utyrylglycine)]. The structures were determined by molecular replacement, and refined to 3.1 A (native) and 2.0 A (complex) resolution. Binding of the inhibitor in the active site induces a conformational change that results in closing of the flap and transforms the active site groove into a tunnel-shaped cavity enclosing 83% of the solvent accessible surface area of the inhibitor. The inhibitor binds in the active site through interactions with residues that are conserved among metallo beta-lactamases; the inhibitor's carboxylate group interacts with Lys161, and the main chain amide nitrogen of Asn167. In the "oxyanion hole", the amide carbonyl oxygen of the inhibitor interacts through a water molecule with the side chain of Asn167, the inhibitor's thiolate bridges the two Zn(II) ions in the active site displacing the bridging water, and the phenylbutyryl side chain binds in a hydrophobic pocket (S1) at the base of the flap. The flap is displaced 2.9 A compared to the unbound structure, allowing Trp28 to interact edge-to-face with the inhibitor's thiophene ring. The similarities between this inhibitor and the beta-lactam substrates suggest a mode of substrate binding and the role of the conserved residues in the active site. It appears that the metallo beta-lactamases bind their substrates by establishing a subset of binding interactions near the catalytic center with conserved characteristic chemical groups of the beta-lactam substrates. These interactions are complemented by additional nonspecific binding between the more variable groups in the substrates and the flexible flap. This unique mode of binding of the mercaptocarboxylate inhibitor in the enzyme active site provides a binding model for metallo beta-lactamase inhibition with utility for future drug design. [less ▲]

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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailEigenschappen van glucosamine
Reginster, Jean-Yves ULg; Halkin, V

in Medi-Sfeer (2000), 116

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See detailSyntaxe et sens de la tournure védique prathamam jayamânah
Swennen, Philippe ULg

in A.I.O.N. Annali dell'Istituto Universitario Orientale di Napoli. Sezione filologico-letteraria (2000), 60-61

The Vedic locution prathamam jâjyamânah is a syntagm, where the first word, used as an adverb, means that the action expressed by the participle happens just before the action of the main verb of the ... [more ▼]

The Vedic locution prathamam jâjyamânah is a syntagm, where the first word, used as an adverb, means that the action expressed by the participle happens just before the action of the main verb of the sentence. Once this rule is established, other examples of this use of prathamam can be identified. This turn, very rare in the texts, was archaic and finally disappeared. [less ▲]

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See detailAdaptation et validation française du Sexual Irrationality Questionnaire (SIQ) de McCormick et Jordan
Kempeneers, Philippe ULg; Louwette, Séverine ULg; Mormont, Christian ULg et al

in Revue Francophone de Clinique Comportementale et Cognitive (2000), 5(3), 5-18

Mc Cormick and Jordan's Sexual Irrationality Questionnaire (SIQ), elaborated in 1986, has been adapted to the French language and tested on a sample of 165 subjects. The organisation of the sexual ... [more ▼]

Mc Cormick and Jordan's Sexual Irrationality Questionnaire (SIQ), elaborated in 1986, has been adapted to the French language and tested on a sample of 165 subjects. The organisation of the sexual rationality-irrationality dimension depends on the gender of the subjects. Among female subjects, it appears mostly as a one-factor variable. Its optimal measure is supplied by the SIQ-R-F scale, a reduced version of the SIQ presenting a better internal consistency. Among male subjects, it rather appears structured in several independent factors. Factor analysis thus allows to distinguish four different patterns of sexual irrationality. Among female subjects, the decisive impact of sexual irrationality lies in an inhibition of sexual interest. Among male subjects, the sexual communication seems to be a vulnerable area of first importance. The external validity test of the SIQ is not very probant. This surely underlines a probable problem in the choice of the criteria as well as the compexity of the relationship between irrational cognitions and clinical data. [less ▲]

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See detailL'altération des bords de la tourbière active du Misten par l'exploitation de la tourbe pourrait dater du début du 14ième siècle
Hindryckx, Marie-Noëlle ULg; Streel, Maurice ULg

in Documents de la Station scientifique des Hautes-Fagnes (2000), 30(4), 95-101

Une étude récente (1999) de la végétation, de la variation du niveau de la nappe aquifère et des caractéristiques de la tourbe sous-jacente, à la périphérie de la tourbière active du Misten permet d ... [more ▼]

Une étude récente (1999) de la végétation, de la variation du niveau de la nappe aquifère et des caractéristiques de la tourbe sous-jacente, à la périphérie de la tourbière active du Misten permet d'entrevoir l'époque la plus probable d'exploitation de la tourbe dans la région de cette tourbière. Un calcul de la vitesse d'accumulation récente de la tourbe à différentes zones à la périphérie de la partie active de la tourbière a été effectué par des sondages de tourbe rapprochés et analysés finement au niveau palynologique. On constate que la vitesse d'accumulation de la tourbe varie selon les profils distants de 10m les uns des autres et que celle-ci diminue au fur et à mesure que l'on se rapproche du bord actuel de la tourbière active. A l'aide d'une datation au carbone 14, nous pouvons avancer que la date de l'altération du bord sud-est de la tourbière active du Misten a dû commencer vers 1330 AD (1170 + 160), soit bien antérieurement au creusement du fossé d'Eupen (1774), mais aussi bien avant les premières exploitations de tourbe connues dans les fagnes de Sourbrodt. [less ▲]

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See detailLate Frasnian - Famennian climates based on palynomorph analyses and the question of the late Devonian glaciations.
Streel, Maurice ULg; Caputo, MV; Loboziak, S et al

in Earth-Science Reviews (2000), 52(1-3), 121-173

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See detailSimenon critique de Simenon. Éléments pour une reconstitution de l'espace des possibles romanesques simenoniens (1938-1948)
Denis, Benoît ULg

in Traces. Travaux du Centre d'Études Georges Simenon (2000), (12), 27-46

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See detailL'ouvrier, l'usine et le syndicalisme wallons. Involutions et enjeux (1960-2000). Le crépuscule des industrieux
Geerkens, Eric ULg

in Reflets et Perspectives de la Vie Economique (2000), (2-3), 254-255

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See detailModulation of human chondrocyte metabolism by recombinant human interferon.
Henrotin, Yves ULg; Zheng, S X; Labasse, A H et al

in Osteoarthritis and Cartilage (2000), 8(6), 474-82

OBJECTIVES: Interferon gamma (IFN gamma) is found to be elevated in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis, suggesting its implication in joint disease pathogenesis ... [more ▼]

OBJECTIVES: Interferon gamma (IFN gamma) is found to be elevated in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis, suggesting its implication in joint disease pathogenesis. In this study, we investigated the effects of IFN gamma on the production of cytokines (IL-6, IL-8, IL-10), prostaglandin E(2)(PGE(2)), proteoglycans (PG), nitric oxide (NO), interleukin-1 receptor antagonist (IL-1ra) and stromelysin by non-stimulated and IL-1 beta-treated human chondrocytes. The role played by NO in the responses of chondrocytes to IFN gamma was also examined by incubation of chondrocytes with N(G)-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NO synthase. METHODS: Enzymatically isolated human chondrocytes were cultured for 48 h in the absence or presence of IL-1 beta, IFN gamma or N(G)-monomethyl-L-arginine (L-NMMA) added solely or in combination. The productions of IL-6, IL-8, IL-10, IL-1ra and stromelysin were measured by enzyme amplified sensitivity immunoassays (EASIA). PG and PGE(2)were quantified by specific radioimmunoassays (RIA). Nitrite concentrations in the culture supernatants were determined by a spectrophotometric method based upon the Griess reaction. RESULTS: As expected, IL-1 beta highly stimulated NO, IL-6, IL-8, IL-10, IL-1ra, PGE(2)and stromelysin synthesis, but dramatically decreased PG production. NO, IL-6, IL-1ra and PGE(2)production by non-stimulated chondrocytes was dose-dependently increased by IFN gamma while PG production was inhibited. In the absence of IL-1 beta, IL-10 was undetectable in the culture supernatants. At the doses of 10 and 100 U/ml, IFN gamma markedly inhibited the constitutive and IL-1 beta-stimulated IL-8, IL-10 and stromelysin productions. Interestingly, IFN gamma synergized with IL-1 beta to increase NO, IL-6, IL-1ra and to depress PG production. As previously reported, the inhibition of NO synthesis by the competitive inhibitor L-NMMA led to enhancement of IL-6, IL-8 and PGE(2)production by IL-1 beta treated chondrocytes, but did not significantly modify IL-10, PG and MMP-3 productions. Inhibition of NO synthase significantly inhibited the stimulating effect of IFN gamma on IL-6 and IL-1ra but did not affect the inhibitory effect of IFN gamma on IL-8, PG or stromelysin production. CONCLUSIONS: These findings suggest that IFN gamma and IL-1 synergistically stimulate the production of IL-6, IL-1ra, NO and PGE(2)and inhibit PG synthesis. By contrast, IL-1 beta and IFN gamma have opposite effects on IL-8, IL-10 and stromelysin productions. These effects are not reversed by L-NMMA, suggesting that NO is not the principal mediator involved in responses of chondrocytes to IFN gamma. [less ▲]

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See detailCoumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
Pochet, Lionel; Doucet, Caroline; Dive, Georges ULg et al

in Bioorganic & Medicinal Chemistry (2000), 8(6), 1489-1501

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See detailMarkers of tumor invasion are major predictive factors for the long-term outcome of corticotroph microadenomas treated by transsphenoidal adenomectomy.
Vallette-Kasic, S.; Dufour, H.; Mugnier, M. et al

in European Journal of Endocrinology (2000), 143(6), 761-8

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN ... [more ▼]

OBJECTIVE: To assess the postsurgical outcome of patients with corticotroph microadenomas and to define predictors of the long-term outcome, with special emphasis on markers of tumor extension. DESIGN: Prospective study of 53 corticotroph microadenomas treated by enlarged adenomectomy. Patients followed for at least 2 years were classified into two groups: those in long-term remission and uncured patients (immediate failures and recurrences). Pre-, per- and postoperative parameters were analyzed as predictors of the long-term outcome. METHODS: Baseline hormone assessments were performed preoperatively, 8 days after surgery and every 6-12 months thereafter. Pituitary magnetic resonance imaging (MRI) allowed analysis of possible tumor extension to adjacent structures. Apparent completeness of the surgical removal was determined, and fragments labeled either 'tumor' or 'surrounding pituitary tissue' were submitted to serial sectioning. RESULTS: Immediate control of hypercortisolism was achieved in 43/53 patients (81%). However, later recurrences were observed in five patients (9%). Preoperative MRI showed tumor extension into adjacent structures with good specificity (91%) for prediction of surgical failure. Evidence of local invasion at surgery was also significantly predictive of the long-term outcome. A corticotroph adenoma was found at histological examination in 96% of the patients, and 26% had irregular limits, a feature significantly correlated with a poor outcome. Immediate postoperative plasma cortisol did not allow discrimination between long-term remissions and recurrences. CONCLUSION: Surgical failure was best predicted by signs of tumor 'invasiveness' at MRI, confirmed by peroperative examination and histology. [less ▲]

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See detailCharacterization of intestinal cnf1+ Escherichia coli from weaned pigs
Toth, I.; Oswald, E.; Mainil, Jacques ULg et al

in International Journal of Medical Microbiology (2000), 290

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See detailCellulite: from standing fat herniation to hypodermal stretch marks.
Pierard, Gérald ULg; NIZET, Jean-Luc ULg; PIERARD-FRANCHIMONT, Claudine ULg

in American Journal of Dermatopathology (2000), 22(1), 34-7

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens ... [more ▼]

There are glaring discrepancies in the microanatomical descriptions of cellulite in the literature. We revisited this common skin condition in women with a microscopic examination of 39 autopsy specimens. A control group consisted of 4 women and 11 men showing no evidence of cellulite. The lumpy aspect of the dermohypodermal interface appeared to represent a gender-linked characteristic of the thighs and buttocks without being a specific sign of cellulite. Incipient cellulite identified by the mattress phenomenon was related to the presence of focally enlarged fibrosclerotic strands partitioning the subcutis. Such strands possibly serve as a physiologic buttress against fat herniation limiting the outpouching of fat lobules on pinching the skin. These structures might represent a reactive process to sustained hypodermal pressure caused by fat accumulation. Full-blown cellulite likely represents subjugation of the hypertrophic response when connective tissue is overcome by progressive fat accumulation. Histologic aspects reminiscent of stretch marks are identified within the hypodermal strands, resulting in clinical skin dimpling. [less ▲]

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See detailPhytothérapie traditionnelle des bovins dans les élevages de la plaine de la Ruzizi
Byavu, N.; Henrard, C.; Dubois, M. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2000), 4(3), 135-156

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See detailOn the scalar meson exchange in the baryon spectra
Stassart, Pierre ULg; Stancu, Floarea ULg; Richard, J. M. et al

in Journal of Physics : G Nuclear & Particle Physics (2000), G26

We explore the role of a scalar meson exchange interaction between quarks in a semirelativistic constituent quark model where the quarks are also subject to a linear confinement. We study how the spectrum ... [more ▼]

We explore the role of a scalar meson exchange interaction between quarks in a semirelativistic constituent quark model where the quarks are also subject to a linear confinement. We study how the spectrum evolves when the strength of the scalar meson exchange increases. Our results are relevant to the long-standing problem of the relative position of the first positive-parity (Roper resonance) and the first orbitally excited states in the baryon spectrum. [less ▲]

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See detailIntestinal maturation induced by spermine in young animals
Peulen, Olivier ULg; Deloyer, P; Grandfils, Christian ULg et al

in Livestock Production Science (2000), 66

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See detailA propos d'un cas de kératite à Acanthamoeba
Carrette, S.; Marechal-Courtois, C.; Hernandez, J. et al

in Bulletin de la Société Belge d'Ophtalmologie (2000), 275

CLINICAL REPORT: A clinical report of a contact lenses wearer with Acanthamoeba keratitis pointed out the diagnosis problem. The medical treatment is needed previously to any surgery. Finally the patient ... [more ▼]

CLINICAL REPORT: A clinical report of a contact lenses wearer with Acanthamoeba keratitis pointed out the diagnosis problem. The medical treatment is needed previously to any surgery. Finally the patient underwent enucleation. DISCUSSION: The authors are considering the microbiological aspects and laboratory techniques are described. CONCLUSION: For this very severe but hopefully rare pathology, the sooner the treatment the best. A therapeutic approach is described. [less ▲]

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See detailField observations on the variability of crude oil impact on indigenous hydrocarbon-degrading bacteria from sub-Antarctic intertidal sediments
Delille, Daniel; Delille, Bruno ULg

in Marine Environmental Research (2000), 49(5), 403-417

Oil pollution of the oceans has been a problem ever since man began to use fossil fuels. Biodegradation by naturally occurring populations of micro-organisms is a major mechanism for the removal of ... [more ▼]

Oil pollution of the oceans has been a problem ever since man began to use fossil fuels. Biodegradation by naturally occurring populations of micro-organisms is a major mechanism for the removal of petroleum from the environment. To examine the effects of crude oil pollution on intertidal bacteria, we repeated the same contamination experiments on nine different sub-Antarctic intertidal beaches using specifically built enclosures (PVC pipe, 15 cm in inner diameter and 30 cm in height). Despite the pristine environmental conditions, significant numbers of indigenous hydrocarbon-degrading bacteria were observed in all the studied beaches. Introduction of oil into these previously oil-free environments resulted in several orders of magnitude of increase in hydrocarbon-degrading micro-organisms within a few days in some of the studied sites but has no obvious effects on two others. The physical environment of the bacterial assemblage seems to play a major role in the biodegradation capacities. After 3 months of contamination, both remaining oil concentrations and biodegradation indexes differ strongly between the different stations. Thus, chemical and biological parameters reveal a strong heterogeneity of biodegradation capacities between the different sites. (C) 2000 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailRadiation therapy alone or combined surgery and radiation therapy in squamous-cell carcinoma of the penis?
Zouhair, A; COUCKE, Philippe ULg; Jeanneret, W et al

in European Journal of Cancer (2000), 37(2), 198203

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the ... [more ▼]

To assess the prognostic factors and the outcome in patients with squamous-cell carcinoma of the penis, a retrospective review of 41 consecutive patients with non-metastatic invasive carcinoma of the penis, treated between 1962 and 1994, was performed. The median age was 59 years (range: 35–76 years). According to the International Union Against Cancer (UICC) 1997 classification, there were 12 (29%) T1, 24 (59%) T2, 4 (10%) T3 and 1 TX (2%) tumours. The N-classification was distributed as follows: 29 (71%) patients with N0, 8 (20%) with N1, 3 (7%) with N2 and 1 (2%) with N3. Forty-four per cent (n=18) of the patients underwent surgery: partial penectomy with (n=4) or without (n=12) lymph node dissection, or total penectomy with (n=1) or without (n=1) lymph node dissection. 23 patients were treated with radiation therapy alone, and all but 4 of the patients who were operated upon received postoperative radiation therapy (n=14). The median follow-up period was 70 months (range 20–331 months). In a median period of 12 months (range 5–139 months), 63% (n=26) of the patients relapsed (local in 18, locoregional in 2, regional in 3 and distant in 3). Local failure (stump in the operated patients, and the tumour bed in those treated with primary radiation therapy) was observed in 4 out of 16 (25%) patients treated with partial penectomy ±postoperative radiotherapy versus 14 out of 23 (61%) treated with primary radiotherapy (P=0.06). 15 (83%) out of 18 local failures were successfully salvaged with surgery. In all patients, 5- and 10-year survival rates were 57% (95% confidence interval (CI), 41–73%) and 38% (95% CI, 21–55%), respectively. The 5-year local and locoregional rates were 57% (95% CI, 41–73%) and 48% (95% CI, 32–64%), respectively. In patients treated with primary radiotherapy, 5- and 10-year probabilities of surviving with penis preservation were 36% (95% CI, 22–50%) and 18% (95% CI, 2–34%), respectively. In multivariate analyses, survival was significantly influenced by the N-classification, and surgery was the only independent factor predicting the locoregional control. We conclude that, in patients with squamous-cell carcinoma of the penis, local control is better in patients treated with surgery. However, there seems to be no difference in terms of survival between patients treated by surgery and those treated by primary radiotherapy ±salvage surgery, with 39% having organ preservation. [less ▲]

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