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See detailCompte rendu de L. Couloubaritsis, J.-J. Wunenburger, La couleur, Bruxelles, 1993 (Recueil, 4)
Marganne, Marie-Hélène ULg

in Archives Internationales d'Histoire des Sciences (1997), 47

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See detailZastosowanie ultrasonografii w diagnostyce klinicznej ukladu rozrodczego u bydla
Gajewski, Z.; Hanzen, Christian ULg; Thun, R. et al

in Nowa Weterynaria (1997)

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See detailRelations entre les conditions d'habitat et la pathologie en production de viande bovine
Nicks, Baudouin ULg

in Aspects de la conception des bâtiments pour les bovins à viande (1997)

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See detailPolymorphous light eruption-like lesions on sun-protected injection sites of recombinant IFN-alpha-2b
Nikkels, Arjen ULg; Delwaide, Jean ULg; Letawe, C. et al

in Journal of Dermatological Treatment (1997), 8(4), 285

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See detailThe Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle
Hardt, Karin; Joris, Bernard ULg; Lepage, Sophie et al

in Molecular Microbiology (1997), 23(5), 935-944

Prediction studies, conformational analyses and membrane-topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in ... [more ▼]

Prediction studies, conformational analyses and membrane-topology mapping lead to the conclusion that the penicillin sensory transducer, BlaR, involved in the inducibility of beta-lactamase synthesis in Bacillus licheniformis, is embedded in the plasma membrane bilayer via four transmembrane segments TM1-TM4 that forma four-alpha-helix bundle. The extracellular 262-amino-acid-residue polypeptide, S340-R601, that is fused at the carboxy end of TM4, possesses the amino acid sequence signature of a penicilloyl serine transferase. It probably functions as penicillin sensor. As an independent entity, this polypeptide behaves as a high-affinity penicillin-binding protein. As a component of the full-size BlaR, it adopts a different conformation presumably because of interactions with the extracellular 63-amino-acid-residue P53-S115 loop that connects TM2 and TM3. Reception of the penicillin-induced signal requires a precise conformation of the sensor but it does not involve penicilloylation of the serine residue S402 of motif STYK. Signal transmission through the plasma membrane by the four-alpha-helix bundle may proceed in a way comparable to that of the aspartate receptor, Tar. Signal emission in the cytosol by the intracellular 189-amino-acid-residue Y134-K322 loop that connects TM3 and TM4, may proceed via the activation of a putative metallopeptidase. [less ▲]

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See detailLe médicament du mois - Le Valaciclovir (Zelitrex)
Pierard, Gérald ULg; Nikkels, Arjen ULg

in Revue Médicale de Liège (1997), 52(8), 553-555

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure ... [more ▼]

Un progrès important vient d'être réalisé dans le traitement du zona. Le valaciclovir (Zelitrex) est un nouveau médicament oral qui est en fait un précurseur de l'aciclovir. Sa biodisponibilité supérieure à celle de l'aciclovir est à l'origine d'un progrès thérapeutique majeur dans la prise en charge du zona cutané chez des sujets immunocompétents de plus de 50 ans et du zona ophtalmique quel que soit l'âge du sujet. Le valaciclovir réduit tant la prévalence que la sévérité des douleurs associées au zona. [less ▲]

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See detailAttitude des élèves face à l'école et au cours d'éducation physique, âge et retard scolaire
Piéron, Maurice; Delfosse, Catherine; Ledent, Maryse et al

in Revue de l'Education Physique (1997), 37(1), 31-41

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois ... [more ▼]

Le terme motivation fait partie du langage habituel des psychologues, des enseignants, des sportifs,... Nous pourrions continuer cette liste sans parvenir à lui donner un caractère exhaustif. Parfois utilisé de manière abusive, ce concept présente néanmoins des aspects théoriques et pratiques fondamentaux. A la notion de motivation, on associe très fréquemment celle d'attitude. Toutes deux sont définies en référence à l'affect, c'est-à-dire à une impression d'attraction ou de répulsion vis-à-vis d'un objet déterminé. ... [less ▲]

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See detailUne grammaire de l'égyptien de la 18e dynastie
Winand, Jean ULg

in Orientalische Literaturzeitung (1997), 92

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See detailAllozyme diversity and genetic structure in South - Western populations of Heather, Calluna vulgaris (L.) Hull
Mahy, Grégory ULg; Vekemans, Xavier; Jacquemart, Anne Laure et al

in New Phytologist (1997), 137

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See detailChanges in the Western Boundary Undercurrent outflow since the Last Glacial Maximum, from smectite/illite ratios in deep Labrador Sea sediments
Fagel, Nathalie ULg; Hillaire-Marcel; Robert, Christian

in Paleoceanography (1997), 12(1), 79-96

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador ... [more ▼]

High-resolution mineralogical studies were performed on late glacial and deglacial sediments from two deep piston cores from the Labrador Sea, located at the inlet (SW Greenland Rise) and outlet (Labrador Rise) of the Western Boundary Undercurrent (WBUC) gyre. At the two sites, smectites transported from the eastern Iceland and Irminger basins by the WBUC are observed. Clay mineral changes are used as proxies for the paleointensity reconstruction of the WBUC. On the Greenland Rise, a clay mineral index (smectite/illite (S/I) ratio) is defined. A S/I ratio of similar to 1 characterized the Last Glacial Maximum. It increased after similar to 17 ka, and reached a maximum value of 4 during the early Holocene, The mineralogical changes are gradual and do not show any reversal during the Younger Dryas, This pattern, which is confirmed by first-order estimations of smectite and illite fluxes, suggests gradually increasing sedimentary fluxes and WBUC intensity since the Last Glacial Maximum, A peak in the velocity of the WBUC at similar to 9 ka, as recorded by clay assemblages, is consistent with other regional studies based on pollen, foraminifera, or grain-size measurements, A massive dilution of smectites by illite and chlorite (S/I approximate to 3) occurs at similar to 8.5 ka. It corresponds to a period of rapid sediment accumulation and reflects an intensified illite-rich detrital supply by meltwaters from the southern Greenland Ice Margin. On the Labrador Rise, the smectite content varies between 20 and 60% with no obvious trend through time. The mineralogical composition is strongly influenced by ice-rafted deposition and by the abundance of fast deposit units (cf, Heinrich layers in the North Atlantic) which contain abundant detrital carbonates spilled-over from the North-West Atlantic Mid-Ocean Channel. In such layers, smectites are present but are diluted by the addition of illites, chlorites, and kaolinites. This provides evidence for a discrete and continuous WBUC supply of fine particles from the Irminger and Iceland Basins as far as the southeastern part of the Labrador Basin, Early deglacial smectite-rich layers (up to 60%) are also observed at this site, They indicate an increase in the outflow of the WBUC at similar to 13.5 ka, (Bolling-Allerod), as previously reported from grain size or foraminiferal assemblage studies. [less ▲]

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See detailA novel seizure-induced synaptotagmin gene identified by differential display.
Babity, J. M.; Armstrong, J. N.; Plumier, Jean-Christophe ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94(6), 2638-41

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of ... [more ▼]

Systemic administration of kainic acid, a cyclic analogue of glutamate, produces many of the clinical features of human temporal lobe epilepsy and status epilepticus in rats, including the induction of motor convulsions and the degeneration of neurons in the hippocampus and piriform cortex. Differential display PCR was used to identify mRNAs that are differentially expressed between degenerating and nondegenerating tissues in the brain after kainic acid-induced seizure activity. A novel cDNA fragment expressed in the degenerating hippocampus and piriform cortex, but not in the nondegenerating parietal cortex, was identified, cloned, and sequenced. This novel cDNA fragment identified a new member of the synaptotagmin gene family that is rapidly and transiently induced in response to seizure activity. Differential expression of this synaptotagmin gene, syt X, was confirmed by Northern blot analysis and in situ hybridization. This novel, inducible synaptotagmin gene may provide a direct link between seizure-induced neuronal gene expression and subsequent modulation of synaptic structure and function. [less ▲]

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See detailTumor collagenase stimulatory factor (TCSF) expression and localization in human lung and breast cancers.
Polette, M.; Gilles, Christine ULg; Marchand, V. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1997), 45(5), 703-9

Tumor cell-derived collagenase stimulatory factor (TCSF) stimulates in vitro the biosynthesis of various matrix metalloproteinases involved in tumor invasion, such as interstitial collagenase, gelatinase ... [more ▼]

Tumor cell-derived collagenase stimulatory factor (TCSF) stimulates in vitro the biosynthesis of various matrix metalloproteinases involved in tumor invasion, such as interstitial collagenase, gelatinase A, and stromelysin 1. The expression of TCSF mRNAs was studied in vivo, using in situ hybridization and Northern blotting analysis, in seven normal tissues and in 22 squamous cell carcinomas of the lung, and in seven benign proliferations and in 22 ductal carcinomas of the mammary gland. By in situ hybridization, TCSF mRNAs were detected in 40 of 44 carcinomas, in pre-invasive and invasive cancer cells of both lung and breast cancers. TCSF mRNAs and gelatinase A mRNAs were both visualized in the same areas in serial sections in breast cancers, and were expressed by different cells, tumor cells, and fibroblasts. The histological results were confirmed by Northern blot analysis, which showed a higher expression of TCSF mRNAs in cancers than in benign and normal tissues. These observations support the hypothesis that TCSF is an important factor in lung and breast tumor progression. [less ▲]

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See detailClostridium spiroforme toxin genes are related to C. perfringens iota toxin genes but have a different genomic localization.
Gilbert, M.; Perelle, S.; Daube, Georges ULg et al

in Systematic & Applied Microbiology (1997), 20

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See detailA propos d'un cas de rupture myocardique dans un traumatisme thoracique ferme.
Demarche, M.; SakalihasanN, Natzi ULg; Limet, Raymond ULg

in Revue Médicale de Liège (1997), 52(2), 105-9

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See detailReassembly of functional nucleoli following in situ unraveling by low-ionic-strength treatment of cultured mammalian cells.
Zatsepina, O. V.; Dudnic, O. A.; Chentsov, Y. S. et al

in Experimental Cell Research (1997), 233(1), 155-68

In order to determine the most persistent components of the nucleolus that might serve as "core" nucleolar elements, we studied the reactivity of nucleoli in living mammalian cells subjected to hypotonic ... [more ▼]

In order to determine the most persistent components of the nucleolus that might serve as "core" nucleolar elements, we studied the reactivity of nucleoli in living mammalian cells subjected to hypotonic buffer saline followed by the incubation of the cells in an isotonic medium. To document as precisely as possible the fine structural changes which occurred, the cells were examined by video-enhanced optical microscopy, fluorescence confocal laser scanning microscopy, and electron microscopy combined with cytochemistry. Light microscopic autoradiography was used to demonstrate the transcriptional characteristics of the reassembled nucleoli. It was shown that all the major compartments of the intact nucleolus could be substantially affected by reduction of the osmolarity of the environmental media. The dynamic events of the nucleolar unraveling in low-salt buffers occurred in the following order: dispersion of the nucleolar pars granulosa, disassociation of the fibrillar complexes into discrete fibrillar centers (FCs) and the dense fibrillar component (DFC), and the almost complete unraveling of the DFC and FCs. At the terminal stages of nucleolar dispersion, the nuclear interior was mainly composed of a loose filamentous meshwork, and none of the typically discerned nucleolar constituents was recognized. Nevertheless, when hypotonically treated cells were returned to isotonic conditions, the nucleolar bodies rapidly began to reassemble. Within 1-2 h of cell incubation under isotonicity, the nucleoli not only became clearly visible, but also reconstituted to their initial size, shape, and position within the nucleus. The ultrastructure and functional activity of the reassembled nucleoli were also found to be fully comparable to those of the untreated controls. These data indicate that the architectural composition of the interphase nucleolus is strictly controlled by the cell. As far as could be determined, none of the usual substructures of the intact nucleolus that could be substituted by complete reassembly of the nucleolar bodies in normotonic conditions, including FCs and the DFC, remained clearly preserved in the terminal stage of nucleolar unraveling. We concluded that the integrity of the nucleolus was mainly preserved by the nuclear or nucleolar matrix system rather than by any other nucleolar structural domains. [less ▲]

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See detailThe Photoabsorption Spectrum of Vinylchloride (C2H3Cl) in the 8-12 eV Range.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1997), 220

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg ... [more ▼]

The photoabsorption spectrum of vinylchloride (C2H3Cl) has been measured using synchrotron radiation and has been analyzed in detail between 8-12 eV photon energy. Valence and virtual valence and Rydberg transitions have been identified and classified. Tentative assignments were based on the ionization energies as measured by He(I)- and threshold photoelectron spectroscopy, as reported in the joined paper. Many features have been identified as being members of vibrational progressions belonging to the observed Rydberg series. [less ▲]

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See detailLinear Benard-Marangoni instability in rigid circular containers
Dauby, Pierre ULg; Lebon, Georgy ULg; Bouhy, E.

in Physical Review. E : Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics (1997), 56(1), 520-530

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See detailPlaidoyer pour une expertise entièrement contradictoire en matière pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailFin du Millénaire - fin de l'Agriculture
Schirmer, Jacek; Schmitz, Serge ULg

in Bulletin de la Société Géographique de Liège (1997), 33

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See detailPresbyphonia voice differencies between the secties in the elderly. comparison by maximum phonation time, phonation quotient and spectral analysis
Morsomme, Dominique ULg; Jamart, Jacques; Boucquey, Donatienne et al

in Logopedics, Phoniatrics, Vocology (1997), 22

This study of 40 elderly subjects (30 women and 10 men) between the ages of 70 to 90, attempts to qualify and quantify their voices and to compare the results with a young population and to establish any ... [more ▼]

This study of 40 elderly subjects (30 women and 10 men) between the ages of 70 to 90, attempts to qualify and quantify their voices and to compare the results with a young population and to establish any differences between the two sexes. The measurements concerned the Vital Capacity (VC), the Maximum Phonation Time (MPT) and the Phonation Quotient (PQ). The equivalent values for a young population were compiled from the literature. Spectral voice analysis was also included in the study. The mean speaking fundamental frequency (Fo) of the voice changes with age; it increases in men and decreases in women (158 Hz in elderly men vs a normal value of 120 Hz; 205 Hz in elderly women vs a normal value of 225 Hz). Ageing influences the vital capacity to the advantage of men (median VC = 2.61 vs 1.61 in elderly men and women, respectively). For sustaining a vowel a, the Maximum Phonation Time (MPT) is significantly better in elderly men (median MPT = 16 sec in elderly men and 12 sec for women). Phonation Quotient does not differ significantly between sexes (median PQ = 153 ml/sec in elderly men and 152 ml/sec in elderly women). Although, the physical capacity of elderly women decreases, their vocal output remains very good when compared to young women. In elderly men, however, there is a phonation quotient decrease of 25 per cent compared to young men. [less ▲]

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See detailJustinien et la langue latine. A propos d'un prétendu oracle rendu à Romulus d'après Jean le Lydien
Rochette, Bruno ULg

in Byzantinische Zeitschrift (1997), 90(2), 413-415

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See detailDe différences en disparités : les effets d'un système éducatif 'non compréhensif'
Lafontaine, Dominique ULg

in Scientia Paedagogica Experimentalis (1997), XXXIV(2), 267-281

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique ... [more ▼]

Cet article examine, à travers le cas de la Communauté française de Belgique, les liens entre l'organisation du système éducatif au début du secondaire (présence de redoublements ou promotion automatique, organisation en tronc commun ou en filières, présence ou non d'une carte scolaire) et différents indices de performance ou d'équité : performances moyennes en lecture à un test international comparatif, degré d'hétérogénéité des performances entre élèves, disparités de rendement selon l'établissement ou la filière fréquenté(e). Les résultats montrent que le redoublement, largement pratiqué en Communauté française de Belgique, ne débouche ni sur des meilleures performances, ni sur une réduction sensible des disparités entre élèves. L'absence de tronc commun et de sectorisation engendre en outre de fortes disparités selon la filière et selon l'établissement fréquenté. Le premier degré du secondaire de la Communauté française, organisé en système 'non compréhensif', semble ainsi de nature à amplifier plutôt qu'à corriger les inégalités entre élèves issus du primaire. [less ▲]

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See detailColestasis asociada a ticlopidina
Diaz Fuenzalida, A.; VALDES SOCIN, Hernan Gonzalo ULg; Laudano, O. et al

in Gastroenterologia y Hepatologia (1997), 20(3), 128-30

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of ... [more ▼]

The case of a 56-years-old male with cholestasis associated with ticlopidine is presented. Cholestasis is an infrequent adverse effect of this drug. The patient was admitted to hospital because of jaundice, choluria, and itching of one month of evolution. The patient had taken ticlopidine twice a day for 3 months up to one week prior to admission for peripheral arteriopathy. Biopsy was performed showing acinar cholestasis and portal inflammatory infiltrate compatible with cholestasis due to hypersensitivity. Ticlopidine was discontinued by the patient himself one week prior to admission. The drug was not readministered and the evolution of the clinical and biochemical parameters of cholestasis decreased. The patient was asymptomatic and laboratory data were normal 4 months later. [less ▲]

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See detailUne nouvelle sagesse en hiératique de la Basse Époque (Papyrus Brooklyn Museum 47.218.135)
Winand, Jean ULg

in Chronique d'Egypte : Bulletin Périodique de la Fondation Egyptologique Reine Elisabeth (1997), 72

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See detailImaging the solar corona in the EUV
Delaboudiniere, J.-P.; Stern, R. A.; Maucherat, A. et al

in Advances in Space Research (1997), 20

The SOHO (SOlar and Heliospheric Observatory) satellite was launched on December 2nd 1995. After arriving at the Earth-Sun (L1) Lagrangian point on February 14th 1996, it began to continuously observe the ... [more ▼]

The SOHO (SOlar and Heliospheric Observatory) satellite was launched on December 2nd 1995. After arriving at the Earth-Sun (L1) Lagrangian point on February 14th 1996, it began to continuously observe the Sun. As one of the instruments onboard SOHO, the EIT (Extreme ultraviolet Imaging Telescope) images the Sun's corona in 4 EUV wavelengths. The He II filter at 304 AË images the chromosphere and the base of the transition region at a temperature of 5 - 8 x 10^4 K; the Fe IX-X filter at 171 AË images the corona at a temperature of ~ 1.3 x 10^6 K; the Fe XII filter at 195 AË images the quiet corona outside coronal holes at a temperature of ~ 1.6 x 10^6 K; and the Fe XV filter at 284 AË images active regions with a temperature of ~ 2.0 x 10^6 K. About 5000 images have been obtained up to the present. In this paper, we describe also some aspects of the telescope and the detector performance for application in the observations. Images and movies of all the wavelengths allow a look at different phenomena present in the Sun's corona, and in particular, magnetic field reconnection. [less ▲]

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See detailRecherche d'information et pragmatisme : II. Utilité sociale de la confirmation d'hypothèses
Dardenne, Benoît ULg; Leyens, J.; Yzerbyt, V. Y.

in Année Psychologique (L') (1997), 97

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See detailEvidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Louis, Renaud ULg; Shute, J.; Biaggi, S. et al

in American Journal of Respiratory & Critical Care Medicine (1997), 155(2), 466-472

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma ... [more ▼]

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects contained increased numbers of eosinophils and levels of eosinophil cationic protein (ECP) and mast cell tryptase. Eosinophil numbers, and ECP and histamine levels correlated with the degree of methacholine airways responsiveness, and ECP, tryptase, and histamine correlated with raised concentrations of albumin. Using the micro-Boyden chamber technique eosinophil chemotactic activity was identified only in the sputum from asthmatics. The correlation between the raised levels of total IgA, IL- 8/IgA complexes, and tryptase and the degree of sputum eosinophilia and ECP levels, suggests possible mechanisms for eosinophil chemotaxis and activation in asthma. Row cytometric analysis of sputum lymphocytes showed an increase in CD4+ T cells and T cells expressing intercellular adhesion molecule-1 (ICAM-1) in asthma which, together with the finding of raised levels of soluble ICAM-1 in the sputum, indicates upregulation of this adhesion molecule. Finally, the proportion of CD16+ natural killer (NK) cells was reduced in the sputum of asthmatics. These observations highlight the importance of the airway inflammation in causing asthma and further confirm the usefulness of sputum induction as a tool in asthma research. [less ▲]

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See detailPsychiatrie de liaison:regards sur une pratique de la psychologie médicale en hôpital général
Triffaux, Jean-Marc ULg

in Revue francaise de psychiatrie et de psychologie médicale (1997)

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See detailDarkness promotes flowering in the absolute long-day requiring plant, Lolium temulentum L. Ceres
Périlleux, Claire ULg; Bernier, Georges ULg; Kinet, Jean-Marie

in Journal of Experimental Botany (1997), 48(307), 349--351

Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly ... [more ▼]

Vegetative plants of the long-day grass Lolium temulentum L. Ceres were exposed to threshold long days or light breaks. Protracted darkness given just afterwards clearly promoted flowering and was weakly inductive on its own. The promotive effect of darkness was restricted to floral induction since further apical development was weak. [less ▲]

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See detailLa langue des Cariens. A propos de B 867
Rochette, Bruno ULg

in Glotta : Zeitschrift für Griechische und Lateinische Sprache (1997), 74

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See detailSur les accents et les marques de quantité dans les papyrus latins
Rochette, Bruno ULg

in Zeitschrift für Papyrologie und Epigraphik (1997), 119

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See detailExpérimentation médicale sur l'être humain. Propositions pour un cadre législatif.
Palermini, Patricia ULg; Delfosse, Marie-Luce

in Revue de Droit de la Santé = Tijdschrift voor Gezondheidsrecht (1997), (5), 333-344

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See detailExpression of c-ets-1 mRNA is associated with an invasive, EMT-derived phenotype in breast carcinoma cell lines.
Gilles, Christine ULg; Polette, M.; Birembaut, P. et al

in Clinical & Experimental Metastasis (1997), 15(5), 519-26

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired ... [more ▼]

We have previously observed in vitro that some stromal proteinases (MMP-2, MT1-MMP) were expressed or activated by invasive carcinoma cell lines exhibiting mesenchymal features, presumably acquired through an epithelial to mesenchymal transition (EMT). To examine the potential contribution of c-ets-1 to this phenotype, we have compared here the expression of c-ets-1 with invasiveness in vitro and expression of vimentin, E-cadherin, uPA, MMP-1 and MMP-3 in a panel of human breast cancer cell lines. Our results clearly demonstrate an association between c-ets-1 expression and the invasive, EMT-derived phenotype, which is typified by the expression of vimentin and the lack of E-cadherin. While absent from the two non-invasive, vimentin-negative cell lines, c-ets-1 was abundantly expressed in all the four vimentin-positive lines. However, we could not find a clear quantitative or qualitative relationship between the expression of c-ets-1 and the three proteinases known to be regulated by c-ets-1, except that when they were expressed, it was only in the invasive c-ets-1-positive lines. UPA mRNAs were found in three of the four vimentin-positive lines, MMP-1 in two of the four, and MMP-3 could not be detected in any of the cell lines. Intriguingly, MDA-MB-435 cells, which exhibit the highest metastatic potential of these cell lines in nude mice, expressed vimentin and c-ets-1, but lacked expression of these three proteinases, at least under the culture conditions employed. Taken together, our results show that c-ets-1 expression is associated with an invasive, EMT-derived phenotype in breast cancer cells, although it is apparently not sufficient to ensure the expression of uPA, MMP-1 or MMP-3, in the vimentin-positive cells. Such proteases regulation is undoubtedly qualified by the cellular context. This study therefore advances our understanding of the molecular regulation of invasiveness in EMT-associated carcinoma progression, and suggests that c-ets-1 may contribute to the invasive phenotype in carcinoma cells. [less ▲]

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See detailAcute Functional Iron Deficiency in Obese Subjects During a Very-Low-Energy All-Protein Diet
Beguin, Yves ULg; Grek, Vincent; Weber, Georges ULg et al

in American Journal of Clinical Nutrition (1997), 66(1), 75-9

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 ... [more ▼]

We examined whether a very-low-energy all-protein diet (VLED) would produce detectable changes in iron as well as in other trace elements. Twenty-five obese patients consumed for 2 wk a VLED containing 70 g protein after a 1-wk period during which total daily energy intake was progressively reduced to 1.26 MJ. Serum iron fell sharply by approximately equal to 50% (P < 0.0001), and despite a small decrease in total-iron-binding capacity, transferrin saturation decreased from 30 +/- 11% to 18 +/- 5% (P < 0.0001). Serum ferritin did not change significantly but serum soluble transferrin receptor (sTfR), an indicator of iron deficiency, increased progressively from 4630 +/- 1110 to 6070 +/- 1390 micrograms/L (P < 0.0001). Changes in sTfR correlated inversely with prior changes in serum iron. Changes in iron metabolism did not translate into changes in erythropoiesis or red cell indexes, but the white blood cell count decreased from 7.3 +/- 1.6 to 6.2 +/- 1.9 x 10(9)/L (P < 0.002). There was no evidence of deficiency for the other trace elements and minerals tested. Daily supplementation with 200 mg Fe in 18 other subjects only partially corrected these observations despite some increase in iron stores. These results indicate that during a 2-wk VLED serum iron is significantly depressed, inducing functional tissue iron deficiency too short in duration to produce alterations in red blood cell indexes. These changes are not mediated by absolute iron deficiency, inflammation, or protein malnutrition but could be related to alterations in the iron storage and release behavior of the reticuloendothelial cell during energy deprivation alone. [less ▲]

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See detailPrévention de l’ostéoporose
Reginster, Jean-Yves ULg

in Medi-Sphere (1997), 6

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See detailLa table des lois de Dune : exercice structuré de créativité intellectuelle en groupe
Broonen, Jean-Paul ULg; Bovy, Michel

in Cahiers Internationaux de Psychologie Sociale (1997), 34(2), 100-109

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See detailPirlindole: a selective reversible inhibitor of monoamine oxidase A. A review of its preclinical properties.
Bruhwyler, J.; Liégeois, Jean-François ULg; Geczy, J.

in Pharmacological Research (1997), 36(1), 23-33

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical ... [more ▼]

Pirlindole is a tetracyclic compound that has been characterized as a potential antidepressant drug. It has pharmacological characteristics in common with both tricyclic antidepressants and classical irreversible monoamine oxidase inhibitors. Its main mechanism of action consists of a selective and reversible inhibition of monoamine oxidase A. Secondarily, it exerts an inhibitory effect on noradrenaline and 5-hydroxytryptamine reuptakes. It has no effect on the dopaminergic and cholinergic systems. It has only a low potential for amplifying tyramine and noradrenaline pressor effect, which makes one expect that it will not be at the basis of a 'cheese effect'. Pirlindole has an absolute bioavailability of between 20 and 30% due to an extensive first-pass effect. Orally, the Tmax varies between 2.5 and 6 h in the rat and 0.8 and 2 h in the dog. Two phases of elimination (7.5 and 34-70 h) are measured in the rat and three phases in the dog (1.3, 10.8 and 185 h); it is extensively metabolized. The rat eliminates mainly unconjugated products while the dog eliminates mostly conjugated products. Acute and chronic toxicological studies have not revealed potentially dangerous effects of the drug at the usual doses. It does not present measurable mutagenic, clastogenic or carcinogenic properties. Thus, pirlindole shows pharmacological, pharmacokinetic and toxicological properties which make it suitable for the management of depression. [less ▲]

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See detailPost-operative adjuvant therapy for non-small-cell lung cancer
Barthelemy, Nicole ULg; Johnson; Arriagada et al

in Lung Cancer (1997), 17(supp 1),

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See detailProprietes interfaciales des films de gluten de farines de qualites boulangeres differentes.
Balla, A.; Blecker, Christophe ULg; Razafindralambo, Hary ULg et al

in Sciences des Aliments (1997), 17(3), 271-278

Interfacial properties of gluten proteins are important in determining flour breadmaking quality especially the gas bubbles stability in dough, which influences the loaf volume and crumb texture. The ... [more ▼]

Interfacial properties of gluten proteins are important in determining flour breadmaking quality especially the gas bubbles stability in dough, which influences the loaf volume and crumb texture. The interfacial properties of gluten extracted from four commercial flours have been studied. The behaviour of gluten monolayer spread at the air-water interface is influenced by the gliadins/glutenins ratio. Films of gluten extracted from flours with high gliadins/glutenins ratio spread more quickly, present a higher stability (Pi c) and are more resistant under high compression. [less ▲]

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See detailLa responsabilité civile et professionnelle des administrateurs
Caprasse, Olivier ULg

in Actualités du Droit (1997)

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See detailExpression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions
Kokorine, Isabelle; NISOLLE, Michelle ULg; Donnez, Jacques et al

in Fertility and Sterility (1997), 68(2), 246-251

Objective: To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis ... [more ▼]

Objective: To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis. Design: Serial sections of peritoneal red and black endometriotic lesions, ovarian endometriotic cysts, and rectovaginal adenomyotic nodules were analyzed by in situ hybridization for the expression of matrix metalloproteinase-1 by silver staining for the integrity of the fibrillar extracellular matrix and by immunolabeling for the abundance of sex steroid receptors. Setting: Academic hospital and research laboratory. Patient(s): Premenopausal women undergoing laparoscopy for endometriosis. Intervention(s): Biopsy of endometriotic lesions, combined with endometrium whenever possible. Main Outcome Measure(s): Expression of matrix metalloproteinase-1 messenger RNA (mRNA). Result(s): Matrix metalloproteinase-1 mRNA was expressed focally in red peritoneal and ovarian endometriosis irrespective of the phase of the menstrual cycle but was not detectable in black peritoneal and rectovaginal lesions. Foci of matrix metalloproteinase-1 expression closely correlated with matrix breakdown and with the absence of P receptors in adjacent epithelial cells. Conclusion(s): Correlation of matrix metalloproteinase-1 expression with activity of endometriotic tissue suggests its involvement in tissue remodeling and bleeding, and possibly in the secondary shedding and reimplantation of endometriotic lesions. [less ▲]

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See detailPit-1 gene polymorphism, milk yield, and conformation traits for Italian Holstein-Friesian bulls
Renaville, Robert ULg; Gengler, Nicolas ULg; Vrech, E. et al

in Journal of Dairy Science (1997), 80(12), 34313438

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See detailLe syndrome hépato-pulmonaire
Lamproye, Anne ULg; Weber, T.; Delwaide, Jean ULg et al

in Revue Médicale de Liège (1997), 52(10), 666-670

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See detailA Deletion in the Bovine Myostatin Gene Causes the Double-Muscled Phenotype in Cattle
Grobet, L.; Martin, L. J.; Poncelet, D. et al

in Nature Genetics (1997), 17(1), 71-74

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled ... [more ▼]

An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia-that is, an increase in the number of muscle fibers rather than in their individual diameter. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (domainant and recessive), oligogenic and polygenic models have been proposed. In the Belgian Blue cattle breed (BBCB), segregation analysis performed both in experimental crosses and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGF beta superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-terminal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle. [less ▲]

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See detailUtilisation de l'habitat par la sérotine commune Eptesicus serotinus en Lorraine belge
Kervyn, Thierry; Brasseur, Jasmine; Libois, Roland ULg

in Bulletin de la Société Neuchâteloise des Sciences Naturelles (1997), 120(2), 35-41

The radiotracking of 10 serotine bats during a period of 73 nights shows that the animals hunt mainly at forest edges and above meadows. The mean distance between the main diurnal roost and hunting ... [more ▼]

The radiotracking of 10 serotine bats during a period of 73 nights shows that the animals hunt mainly at forest edges and above meadows. The mean distance between the main diurnal roost and hunting grounds is 2.1 +/- 1.2 km (n = 24). Secondary diurnal roosts are used within a radius of 250 m of the main diurnal quarters. Nocturnal resting places are situated in beech forests (Fagus sylvatica) near feeding areas. The activity area (minumum area method) of radiotracked serotine bats, all originating from the same colony, stretches to 15.8 km². [less ▲]

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See detailCombined Effect of Web 2086 (Paf Antagonist) and Ketoprofen (Nsaid) on Paf-Induced Ex Vivo Platelet Aggregation in Bovine
Bastos da Silva, Miriam; Herion, Francine ULg; Raskinet, Renée ULg et al

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1997), 44(2), 65-71

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich ... [more ▼]

The effect of the specific PAF-antagonist WEB 2086, a thieno-triazolo-diazepine, and ketoprofen, a NSAID, was investigated on PAF-induced bovine platelet aggregation measured ex vivo in platelet-rich plasma (PRP). WEB 2086 was infused intravenously over 1 min followed immediately by ketoprofen administration over 1 s (both drugs = 3 mg/kg), in a group of six healthy male Friesian calves. Depending on the PAF concentration, a reversible (10(-8)-10(-9) mol/l) and irreversible (10(-5)-10(-7) mol/l) platelet aggregation was observed. The reversible aggregation was completely blocked by pretreatment of the animal with WEB 2086 and ketoprofen. The inhibitory effects observed during the irreversible aggregation were 47.22%, 54.00% and 88.00% at 10(-5), 10(-6) and 10(-7) mol/l PAF, respectively. Moreover, the aggregation obtained in these condition became reversible. Maximal inhibitory effect of WEB 2086 and ketoprofen on PAF-induced platelet aggregation in calves was observed within 30 min after administration of both drugs. This inhibition persisted even after 24 h and was significantly different from control with P < 0.05. The combined effect of both drugs exceeded the sum of the individual effects (synergism). It was concluded that WEB 2086 and ketoprofen very effectively blocked PAF-induced bovine platelet aggregation in platelet-rich plasma. The study also suggested a synergism between both substances. [less ▲]

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See detailLes modes de transmission du virus de l'hépatite C
Delwaide, Jean ULg; Gerard, Christiane ULg; Sondag, Danièle ULg et al

in Médecine & Chirurgie Digestives (1997), 26

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See detailPeritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities
NISOLLE, Michelle ULg; Donnez, Jacques

in Fertility and Sterility (1997), 68(4), 585-596

Objective: To review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions. Design: The comparison of morphologic, morphometric, and histochemical data observed in each type of ... [more ▼]

Objective: To review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions. Design: The comparison of morphologic, morphometric, and histochemical data observed in each type of lesion. Setting: A university hospital department of gynecology. Patient(s): Patients complaining of infertility or pelvic pain with laparoscopically proved endometriosis. Intervention(s): Laparoscopy was performed, and biopsy specimens from the endometriotic lesions were histologically studied. Result(s): Three types of endometriotic lesions must be considered: peritoneal, ovarian, and rectovaginal. Morphologic and morphometric data show similarities between eutopic endometrium and red peritoneal lesions, suggesting that these lesions are the first stage of early implantation of endometrial glands and stroma. After partial shedding, the red lesions regrow constantly. The shedding induces an inflammatory reaction, provoking scarification, and the lesions become black. The subsequent fibrosis leads to areas of white opacification that are inactive. The pathogenesis of ovarian endometriomas is a source of controversy. Although there seems to be a consensus concerning the invagination theory, there is still a contradiction between the implantation theory and the metaplasia theory. We recently showed that the mesothelium covering the ovary can invaginate into the ovarian cortex, pushing back the primordial follicles. The presence of mesothelial invagination in continuum with endometriotic tissue suggests that metaplastic histogenesis of ovarian endometriotic lesions occurs. Rectovaginal endometriotic nodules must be considered adenomyomas, consisting of smooth muscle with active glandular epithelium and scanty stroma. Immunocytochemical results show poor differentiation and hormonal independence of these lesions and indicate a close relation with their mesodermal müllerian origin. Conclusion(s): Peritoneal, ovarian and rectovaginal endometriotic lesions must be considered as three separate entities with different pathogeneses. [less ▲]

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See detailOzone-Induced Stimulation of Pulmonary Sympathetic Fibers: A Protective Mechanism against Edema
Delaunois, Annie ULg; Segura, P.; Dessy, Cécile ULg et al

in Toxicology and Applied Pharmacology (1997), 147(1), 71-82

Tropospheric ozone exerts well-described toxic effects on the respiratory tract. Less documented, by contrast, is the ability of ozone to induce protective mechanisms against agents that are toxic to the ... [more ▼]

Tropospheric ozone exerts well-described toxic effects on the respiratory tract. Less documented, by contrast, is the ability of ozone to induce protective mechanisms against agents that are toxic to the lungs. In particular, interactions between ozone and the sympathetic nervous system have never been considered. Using a model of permeability edema in isolated perfused rabbit lungs, we report here that, immediately after exposure of rabbits to 0.4 ppm ozone for 4 hr, the pulmonary microvascular responses to acetylcholine and substance P are completely blocked. Several lines of evidence, including partial inhibition of the ozone-induced protective effect by several drugs (alpha2- and beta-adrenergic antagonists, neuropeptide Y antagonist, guanethidine), measured levels of released catecholamines in blood and urine and the in vitro response of isolated lungs exposed to 0.4 ppm ozone all seem to suggest that ozone can stimulate pulmonary adrenergic fibers and induce the local release of catecholamines and neuropeptide Y, this resulting in transient protection against pulmonary edema. We also showed that, 48 hr after the exposure, ozone increased the baseline microvascular permeability and the response to low concentrations of acetylcholine [less ▲]

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See detailExamen échographique de l'articulation métacarpo-phalangienne. Corrélation signes échographiques - lésions
Denoix, Jean-Marie; Thill, Emanuelle; Houliez, Didier et al

in Pratique Vétérinaire Equine (1997), 29

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and ... [more ▼]

This paper is the result of an ex-vivo study on ultrasonography of the equine fetlock. Abnormal findings in equine isolated limbs have been compared to macroscopic findings after dissections and sensitivity and specificity of the technique have been calculated. [less ▲]

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See detailExperimental induction of prenucleolar bodies (PNBs) in interphase cells: interphase PNBs show similar characteristics as those typically observed at telophase of mitosis in untreated cells.
Zatsepina, O. V.; Dudnic, O. A.; Todorov, I. T. et al

in Chromosoma (1997), 105(7-8), 418-30

Recently, it was shown that a short exposure of living mammalian cells to low ionic strength buffers (hypotonic shock) caused partial or almost complete unraveling of interphase nucleoli. However, when ... [more ▼]

Recently, it was shown that a short exposure of living mammalian cells to low ionic strength buffers (hypotonic shock) caused partial or almost complete unraveling of interphase nucleoli. However, when the cells were released from the hypotonic shock and transferred to normal isotonic medium, functionally active and structurally integral nucleoli were reassembled at their initial positions within interphase nuclei. Here, we show further that this process is accompanied by the appearance of numerous discrete extranucleolar bodies, which have striking similarities to the prenucleolar bodies (PNBs) observed in untreated cells at telophase of mitosis. (1) Like PNBs at mitosis, hypotonically induced interphase PNBs are composed of RNA-positive granules and fibrils, contain the major nucleolar protein B23 and silver-binding proteins, but lack DNA and RNA polymerase I transcription factor UBF. (2) As for mitotic PNBs, disappearance of the interphase PNB counterparts coincides with the increase in size of reconstructed nucleoli. (3) Addition of actinomycin D does not prevent assembly of interphase PNBs, but does arrest their coalescence with the chromosomal nucleolus-organizing regions and blocks the complete reformation of nucleoli. It is concluded that the assembly of PNBs generally observed at telophase of mitosis can be induced experimentally in nuclei of interphase mammalian cells in vivo. At interphase, this process is probably initiated by changes in the intracellular ionic environment. [less ▲]

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See detailLe dessaisissement du juge d'instruction
Jacobs, Ann ULg

in Revue de Droit Pénal et de Criminologie (1997)

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See detailComplications hepatiques de la chimiotherapie. De la cytolyse banale a la maladie veino-occlusive du foie.
Baron, Frédéric ULg; Beguin, Yves ULg

in Revue Médicale de Liège (1997), 52(2), 93-7

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See detailUse of recombinant human erythropoietin after allogeneic bone marrow transplantation
Hermanne, J.-P.; Beguin, Yves ULg

in Erythropoiesis (1997), 8

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See detailPit-1 gene HinfI RFLP and growth traits in double-muscled Belgian Blue cattle
Renaville, Robert ULg; Gengler, Nicolas ULg; Parmentier, Isabelle et al

in Journal of Animal Science (1997), 75(1), 146

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See detailEvolution of coronary atherosclerosis in patients with mild coronary artery disease studied by serial quantitative coronary angiography at 2 and 4 years follow-up. The Multicenter Anti-Atheroma Study (MAAS) Investigators.
Vos, J.; de Feyter, P. J.; Kingma, J. H. et al

in European heart journal (1997), 18(7), 1081-9

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The ... [more ▼]

AIMS: Angiographic studies on the natural course of both focal and diffuse coronary atherosclerosis have not been performed before, but can both be assessed by quantitative coronary angiography. The objective of this study was to describe the natural course of focal and diffuse coronary atherosclerosis over time. METHODS AND RESULTS: In 129 patients with mild coronary artery disease, but not on lipid-lowering medication, three coronary angiograms were made each 2 years apart. Nine hundred and sixty five angiographically diseased and non-diseased segments were analysed by quantitative coronary angiography. Mean lumen diameter and minimal lumen diameter were used as measures of diffuse and focal coronary atherosclerosis. Mean lumen diameter and minimum lumen diameter decreased by 0.02 and 0.03 mm per year. The rate of progression was similar in the angiographically non-diseased, as in the mildly and moderately diseased segments. Progression of diffuse coronary atherosclerosis was largest in severely stenosed lesions (percentage diameter stenosis > or = 50%) and in the right coronary artery with a loss of 0.19 mm and 0.16 mm in mean lumen diameter. Progression of focal disease was most prominent in new and mild lesions and the right coronary artery, with a decrease in minimum lumen diameter of 0.34 mm and 0.22 mm. In most subgroups, progression occurred gradually over time. On a per segment level, progression and the occurrence of new lesions occurred in 4.4% and 4.2%. Regression and disappearance of a lesions was found in 2.3% and 1.9%. On a per patient level, 36% were progressors, 12% had a mixed response, 36% were stable, and 16% were regressors. CONCLUSION: Diffuse and focal coronary atherosclerosis progressed at the same rate in the first and second 2 years in stenosed and non-stenosed segments. The rate of coronary atherosclerosis progression was small, but was higher for focal than for diffuse disease. A minority of lesions progressed and spontaneous regression was rare. [less ▲]

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See detailIdiopathic hypertrophic cranial pachymeningitis mimicking multiple meningiomas: case report and review of the literature.
Deprez, Manuel ULg; Born, Jacques; Hauwaert, Cécile ULg et al

in Acta Neuropathologica (1997), 94(4), 385-9

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were ... [more ▼]

A case of idiopathic hypertrophic cranial pachymeningitis with an unusual and misleading manifestation is reported. Computed tomography scan, angiographic and magnetic resonance imaging findings were suggestive of multiple meningeal neoplasms and a correct diagnosis was made only after meningeal biopsy. This 44-year-old patient had a previous history of an ill-defined systemic disorder associating episcleritis, erythroderma nodosa and multiple peripheral arthritis. We review previous reports of idiopathic cranial pachymeningitis with emphasis on radiological investigation techniques, histopathology and possible dysimmune mechanisms of pathogenesis. [less ▲]

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See detailGenetic Diversity In Lima Bean (Phaseolus Lunatus L) As Revealed By Rapd Markers
Fofana, B.; Vekemans, X.; Du Jardin, Patrick ULg et al

in Euphytica (1997), 95(2),

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See detailChanging sensitivity to duration in human scalar timing: An experiment, a review, and some possible explanations
Ferrara, André ULg; Lejeune, Helga ULg; Wearden, J. H.

in Quarterly Journal of Experimental Psychology. B, Comparative & Physiological Psychology (1997), 50B

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See detailGenetic Structure Of A Lima Bean Base Collection Using Allozyme Markers
Maquet, A.; Bi, Iz.; Delvaux, M. et al

in Theoretical & Applied Genetics = Theoretische und Angewandte Genetik (1997), 95(5-6),

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See detailDensity-functional theory of polar insulators
Gonze, X.; Ghosez, Philippe ULg; Godby, R. W.

in Physical Review Letters (1997), 78(2), 294-297

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not ... [more ▼]

We examine the density-functional theory of macroscopic insulators, obtained in the large-cluster limit or under periodic boundary conditions. For polar crystals, we find that the two procedures are not equivalent. In a large-cluster case, the exact exchange-correlation potential acquires a homogeneous ''electric field'' which is absent from the usual local approximations, and the Kohn-Sham electronic system becomes metallic. With periodic boundary conditions, such a field ist forbidden, and the polarization deduced from Kohn-Sham wave functions is incorrect even if the exact functional is used. [less ▲]

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See detailSurface-active properties of surfactin iturin A mixtures produced by Bacillus subtilis
Razafindralambo, Hary ULg; Popineau, Yves; Deleu, Magali ULg et al

in Langmuir (1997), 13(23), 6026-6031

Surface-active properties including dynamic adsorption, monolayer stability, micelle forming capacity, and foaming aptitudes of surfactin-C-15/iturin A-C-15 mixtures were studied. Surfactin-C-15 and ... [more ▼]

Surface-active properties including dynamic adsorption, monolayer stability, micelle forming capacity, and foaming aptitudes of surfactin-C-15/iturin A-C-15 mixtures were studied. Surfactin-C-15 and iturin A-C-15 molecules interact in synergism on the most surface-active properties evaluated at 20 degrees C at the air-water interface and in aqueous solution (pH 8.0). The synergism is positive on the adsorption effect, monolayer stability, foam density, and liquid stability in foam, whereas it is negative on the adsorption rate. No synergism occurs an micelle forming capacity, but surfactin-C-15 and iturin A-C-15 form mixed micelles when the solution contains a low proportion of surfactin-C-15.ses the synergistic effect is maximum when surfactin-C-15 and iturin A-C-15 molecules are mixed in a 2:3 ratio. This is attributed to the surfactin/iturin A complex formation resulting from specific interactions among two surfactin-C-15 molecules and three iturin A-C-15 molecules. A model of such a complex formation is proposed. [less ▲]

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See detailAlteration of radiation response in vitro by simultaneous modulation of the de novo and salvage pathways to deoxynucleoside triphosphate pool by (E)-2′-Deoxy-(Fluoromethylene)cytidine and thymidine analogs
Coucke, Philippe ULg; Li, Ye-Xiong; Cottin, Eliane et al

in International Journal of Radiation, Oncology, Biology, Physics (1997), 39(2 (supp1)), 257

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See detailL'article 185, alinéa 2, du Code civil et les opérations sur titres
Partsch, Philippe-Emmanuel ULg

in Revue Pratique des Sociétés (1997)

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See detailEnhancement of Tamoxifen-Induced E-Cadherin Function by Ca2+ Channel Antagonists in Human Breast Cancer Mcf7/6 Cells
Charlier, Corinne ULg; Bruyneel, E.; Lechanteur, Chantal ULg et al

in European Journal of Pharmacology (1996), 317(2-3), 413-6

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to ... [more ▼]

Despite its intensive use in adjuvant breast cancer therapy for more than 30 years, the exact mechanisms of action of tamoxifen have not yet been fully characterized. Tamoxifen was recently shown to restore the E-cadherin function of human breast cancer MCF7/6 cells and to suppress their invasive phenotype. Because tamoxifen interacts with targets implicated in Ca2+ homeostasis, we explored the possibility that the restoration of E-cadherin function in MCF7/6 cells induced by this drug could be affected by Ca2+ modulators. Two different Ca2+ channel antagonists (verapamil and nifedipine) potentiated the effect of tamoxifen on E-cadherin function, as evaluated with a fast cell aggregation assay. These molecules decreased the tamoxifen concentration needed to restore the E-cadherin function from 10(-6) M to 10(-7) M. When incubated with a Ca2+ channel agonist, Bay K8644 (methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methylphenyl)- pyridine-5-carboxylate), the effect of tamoxifen on E-cadherin function was completely abolished. These results demonstrate that the restoration of the E-cadherin function induced by tamoxifen depends, at least in part, on a Ca2+ pathway, and support the evidence of an effect of tamoxifen on Ca(2+)-dependent mechanisms. Our data also suggest that Ca2+ channel modulators could make it possible to decrease the dose of tamoxifen administered to patients without reducing the therapeutic effects. [less ▲]

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See detailPoly[alkyl methacrylate-b-butadiene-b-alkyl methacrylate] triblock copolymers : synthesis, morphology, and mechanical properties at high temperatures
Yu, Jian Ming; Teyssié, Philippe; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8362-8370

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl ... [more ▼]

Block copolymers of the ABA type, where B is polybutadiene (PBD) and A is poly(ethyl methacrylate) (PEMA), poly(tert-butyl methacrylate) (P-t-BMA), poly(methyl methacrylate) (PMMA), or poly(isobornyl methacrylate) (PIBMA), have been successfully synthesized by sequential anionic polymerization of butadiene and methacrylates with the diadduct of tert-butyllithium to m-diisopropenylbenzene as a difunctional initiator. Block copolymers of a narrow molecular weight distribution (1.10) have been analyzed by differential scanning calorimetry, transmission electron microscopy, and dynamic mechanical analysis. These materials are phase-separated and have high mechanical performances. Special attention has been paid to the service temperature of these thermoplastic elastomers in comparison with a styrene−butadiene−styrene (SBS) triblock copolymer. The upper service temperature (UST) has been estimated from the temperature dependence of the tensile properties in the 25−150 °C range and found to change with the outer blocks. Polystyrene (Tg = 100°C) is at the origin of the lower UST, which is however comparable to PEMA (Tg = 90 °C) and P-t-BMA (Tg = 116 °C) containing triblock copolymers of similar molecular weight and composition. PMMA (Tg = 132 °C) outer blocks increase the UST of the triblocks, which is further increased by hydrogenation of the PBD midblock. The higher UST has been found for a PIBMA (Tg = 202 °C)-containing triblock copolymer that shows an ultimate tensile strength higher than 2 MPa at 150 °C. [less ▲]

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See detailTriblock copolymer based thermoreversible gels. 3. Effect of stereocomplexation with iPMMA
Yu, Jian Ming; Jérôme, Robert ULg

in Macromolecules (1996), 29(26), 8371-9378

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large ... [more ▼]

Thermoreversible gelation of syndiotactic poly(methyl methacrylate) (sPMMA)−polybutadiene (PBD)−sPMMA, triblock copolymers in o-xylene has been studied in the presence of isotactic PMMA (iPMMA) in a large range of syndio/iso mixing ratio (s/i). Differential scanning calorimetry (DSC) shows that two types of association contribute to the gel formation, i.e., the self-aggregation of the sPMMA outer blocks and the stereocomplexation of the sPMMA outer blocks with iPMMA. At low iPMMA contents (s/i = 30/1), self-association of the outer blocks accounts for the gelation process, although stereocomplexation occurs. Stereocomplexation becomes the dominant gelation mechanism at a high enough iPMMA content (s/i = 2/1). Thus, gelation is observed at a copolymer concentration as low as 1 wt %. The time dependence of the storage (G‘) and loss (G‘‘) moduli has been measured in the 0.08−1Hz frequency range in order to probe the gelation process. At the gel point, where the loss angle (tan δc = G‘‘/G‘) is independent of the probing frequency, the sample fits in the typical power law G‘(ω) G‘‘(ω) ωΔ. While the gelation time is greatly influenced by the s/i mixing ratio, the scaling exponent Δ is essentially constant in the range of 0.70−0.75. The Δ value agrees with theoretical predictions as well as with experimental values reported for some chemical gels but it is different from the experimental values reported for most physical gels. The Δ value is also independent of the PBD microstructure and it also holds for sPMMA-polystyrene (PS)−PBD−PS−sPMMA (MSBSM) pentablock copolymers. Therefore, the value of Δ appears to be a typical exponent for thermoplastic gels based on triblock copolymers of the ABA type in o-xylene. [less ▲]

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See detailInterleukin-1 Beta Induces Nuclear Factor Kappa B in Epithelial Cells Independently of the Production of Reactive Oxygen Intermediates
Bonizzi, Giuseppina; Dejardin, Emmanuel ULg; Piret, Bernard et al

in European Journal of Biochemistry (1996), 242(3), 544-9

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B ... [more ▼]

A large body of work has been devoted to tumor necrosis factor alpha or interleukin-1 beta (IL-1 beta) signaling leading to the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) in various cell types. Several studies have indicated that NF-kappa B activation depends strictly on the production of reactive oxygen intermediates. In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines (OVCAR-3, SKOV-3, MCF7 A/Z). In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105. We showed that IL-1 beta-mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2. Our study demonstrated that several signaling pathways lead to the activation of NF-kappa B, following IL-1 beta treatment in different cell types. [less ▲]

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See detailIdentification of the active gene coding for the metastasis-associated 37LRP/p40 multifunctional protein.
Clausse, Nathalie; Jackers, Pascale ULg; Jares, P. et al

in DNA & Cell Biology (1996), 15(12), 1009-23

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents ... [more ▼]

A 37LRP/p40 polypeptide is of major interest because it is consistently up-regulated in cancer cells in correlation with their invasive and metastatic phenotype. Furthermore, this polypeptide presents intriguing multifunctional properties because it has been characterized as the precursor of the metastasis-associated 67-kD laminin receptor (67LR) and as a cytoplasmic ribosomal-associated protein. The isolation of the 37LRP/p40 gene is a prerequisite for identifying the molecular mechanisms responsible for the constant up-regulation of the 67LR expression in cancer cells. To date, the active 37LRP/p40 gene has never been identified in any species due to the existence of multiple pseudogenes in most vertebrates genomes. In this study, we report for the first time the gene structure and potential regulatory sequences of the 37 LRP/p40 gene. The chicken genome was selected to undergo this characterization because it is the only known vertebrate that bears a single 37 LRP/p40 gene copy. The 37 LRP/p40 active gene is composed of 7 exons and 6 introns and bears features characteristic of a ribosomal protein gene. It does not bear a classical TATA box and it exhibits several transcription initiation sites as demonstrated by RNase protection assay and primer extension. Analysis of potential regulatory regions suggests that gene expression is driven not only by the 5' genomic region but also by the 5' untranslated and intron 1 sequences. On the basis of gene structure and extensive protein evolutionary study, we found that the carboxyterminal domain of the protein is a conserved lock-and-key structure/function domain that could be involved in the biosynthesis of the higher-molecular-weight 67-kD laminin receptor in vertebrates, whereas the central core of the protein would be responsible for the ribosome associated function. The first identification of the active 37LRP/p40 gene presented in this study is a critical step toward the isolation of the corresponding human gene and the understanding of the molecular mechanisms involved in the up-regulation of its expression during tumor invasion and metastasis. [less ▲]

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See detailTnp-470 (Agm-1470): Mechanisms of Action and Early Clinical Development
Castronovo, Vincenzo ULg; Belotti, D.

in European Journal of Cancer (1996), 32A(14), 2520-7

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See detailReduction in Requirements for Allogeneic Blood Products: Pharmacologic Methods
Janssens, Marc ULg; Hartstein, Gary ULg; David, Jean-Louis ULg

in Annals of Thoracic Surgery (1996), 62(6), 1944-50

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic ... [more ▼]

BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic antifibrinolytics. METHODS: A review of the literature was carried out to help the reader define the indications of these drugs during cardiopulmonary bypass operations, highlight the questions that remain concerning their indications and modes of action, and suggest future studies to answer these remaining questions. RESULTS: Prostacyclin reduces platelet trauma induced by extracorporeal circulation but does not effectively reduce postoperative bleeding and transfusion requirements. Desmopressin acts as a "glue," improving platelet adhesion, and may be effective when postoperative bleeding is excessive, but its routine use in cardiac operations cannot be recommended. Natural and synthetic antifibrinolytics inhibit plasmin and plasmin-induced platelet dysfunction. These agents have been shown to decrease bleeding and the need for allogeneic transfusions after open heart operations. However, with antifibrinolytic drugs, the risk of thromboembolic phenomena cannot be neglected. With aprotinin, this risk appears to be minimal when the drug is used at concentrations high enough to inhibit plasma kallikrein also. CONCLUSIONS: Prophylactic antifibrinolytics are efficacious, but their routine use remains controversial, both for economic reasons and for fear of thromboembolic complications. [less ▲]

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See detailScreening and characterization of specific anti-lipopolysaccharide antibodies in Belgian blood donors by enzyme-linked immunosorbent assays
Nys, Monique ULg; Laub, R.; Damas, Pierre ULg et al

in European Journal of Clinical Investigation (1996), 26(12), 1134-1142

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs ... [more ▼]

The goal of this project was to find and collect high concentrations of endotoxin-specific antibodies for therapeutic IgG- or IgM-enriched preparations. Various enzyme-linked immunosorbent assays (ELISAs) were developed to perform longitudinal studies of the serological response to a large panel of smooth and rough purified lipopolysaccharide (LPS) extracts in a population of healthy blood donors. To accomplish this, 1612 human serum samples from volunteer blood donors collected by seven different blood banks in Belgium were screened and specific IgM and IgG activities were measured. Approximately 17% of the donors had anti-LPS concentrations higher than 40 mg L-1. Of these, 10.9% had anti-smooth LPS antibodies, 3.7% had anti-rough LPS antibodies and 2.8% were found to be positive towards both types of LPS. The mean anti-LPS antibody concentration was 8 mg L-1 for rough LPS and 14 mg L-1 for smooth LPS. Age- and sex-related distributions of the activities indicated that the greatest prevalence of high anti-LPS concentration was in women aged 40-49 years and in men older than 60 years. Differential absorption experiments showed that the pooled serum of selected blood donors contained a mixture of specific and cross-reacting antibodies. We detected predominantly anti-LPS activities due to the IgG1 and IgG2 subclasses. The range of specificities to different LPS was increased by the pooling of selected sera. It was concluded that pools of naturally occurring specific anti-LPS immunoglobulin antibodies may be obtained in Belgium by screening blood donors using ELISAs that we have developed. [less ▲]

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See detailAnionic polymerization of various methacrylates initiated with LiCl-complexed sBuLi
Antoun, S.; Wang, Jin-Shan; Jérôme, Robert ULg et al

in Polymer (1996), 37(25), 5755-5759

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert ... [more ▼]

A simple alkyl lithium initiator (sBuLi) complexed with LiCl (10 molar equiv.) has been used to initiate the anionic polymerization of various methacrylic monomers, i.e. methyl methacrylate (MMA), tert-butyl methacrylate (tBuMA), glycidyl methacrylate (GMA), and dimethyl amino ethyl methacrylate (DMAEMA) in tetrahydrofuran at -78°C. Only the homopolymerization of tBuMA proceeds in a living manner, as evidenced by both the linear plot of experimental molecular weight (Mnexp) vs theoretical ones (Mncal,) (slope % 0.93) and monomer resumption experiments. However, three types of block copolymers, i.e. PtBuMA-b-PMMA, PtBuMA-b-PGMA, PtBuMA-b-PDMAEMA, have been successfully synthesized with a predictable molecular weight, and narrow molecular weight distribution. [less ▲]

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See detailDo Sex Differences in the Brain Explain Sex Differences in the Hormonal Induction of Reproductive Behavior? What 25 Years of Research on the Japanese Quail Tells Us
Balthazart, Jacques ULg; Tlemcani, O.; Ball, G. F.

in Hormones & Behavior (1996), 30(4), 627-61

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the ... [more ▼]

Early workers interested in the mechanisms mediating sex differences in morphology and behavior assumed that differences in behavior that are commonly observed between males and females result from the sex specificity of androgens and estrogens. [less ▲]

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See detailOncological Applications of Positron Emission Tomography with Fluorine-18 Fluorodeoxyglucose
Rigo, Pierre ULg; Paulus, Patrick; Kaschten, Bruno et al

in European Journal of Nuclear Medicine (1996), 23(12), 1641-74

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical ... [more ▼]

Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications at different stages of diagnosis, and for staging and follow-up. This review first considers the biological characteristics of FDG and then discusses methodological considerations regarding its use. Clinical indications are considered, and the results achieved in respect of various organs and tumour types are reviewed in depth. The review concludes with a brief consideration of the ways in which clinical PET might be improved. [less ▲]

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See detailStaging of the Mediastinum: Value of Positron Emission Tomography Imaging in Non-Small Cell Lung Cancer
Bury, Thierry ULg; Paulus, P.; Dowlati, A. et al

in European Respiratory Journal : Official Journal of the European Society for Clinical Respiratory Physiology (1996), 9(12), 2560-4

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical ... [more ▼]

Recent studies have shown limitations of morphological imaging in staging mediastinal lymph node involvement in lung cancer. In contrast to computed tomography (CT), which depends primarily on anatomical imaging features, positron emission tomography (PET) with 18-fluorodeoxyglucose (FDG) depends mainly on the metabolic characteristics of a tissue for the diagnosis of disease. We have performed a prospective study comparing FDG-PET and CT of the thorax in the presurgical assessment of the mediastinum in 50 patients with newly diagnosed non-small cell lung cancer (NSCLC). CT and PET scans were interpreted separately, and results were compared to pathological staging obtained during thoracotomy. Hilar or mediastinal lymph node involvement was present in 58%. In staging for lymph node involvement, CT had a sensitivity of 72% and specificity of 81%, whereas PET had a sensitivity and specificity of 90% and 86%, respectively. When the PET study was compared to histological results, there were four cases showing more advanced mediastinal involvement with PET and four cases showing less involvement with PET. From our preliminary results, we conclude that positron emission tomography with 18-fluorodeoxyglucose is significantly more accurate than computed tomography in the mediastinal staging of non-small cell lung cancer. [less ▲]

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See detailMicrostructure development in isothermally melt-textured 123-211 composite materials
Auguste, F.; Rulmont, André ULg; Vandewalle, Nicolas ULg et al

in Journal of Low Temperature Physics (1996), 105(5-6), 1439-1444

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the ... [more ▼]

Microstructures of isothermally melt-textured 123-211 composite materials have been examined during the solidification process from quenched specimens. The distribution of 211 particles, the superconducting 123 grain boundary and the solid-liquid interface features are emphasized. The quality of the materials has been investigated by thermopower and thermal conductivity measurements. A seeded-melt texturing technique has been also tested in order to grow large single-domain of DyBa2Cu3O7-y. The chosen seed was a Dy2O3 single crystal. [less ▲]

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See detailLa CEI entre mythes et réalités
Bachkatov, Nina ULg

in Monde Diplomatique (Le) : Journal des Cercles Diplomatiques et des Grandes Organisations Internationales (1996)

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See detailGliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ULg; de Leval, L.; Reznik, M.

in Acta Neurologica Belgica (1996), 96(4), 294-300

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]

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See detailAdaptation de la méthodologie des langues étrangères aux styles d'apprentissage des élèves : un nouveau miroir aux alouettes ?
Simons, Germain ULg

in Etudes et Travaux (1996), (1), 19-38

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le ... [more ▼]

Selon certains spécialistes de l'apprentissage d'une langue étrangère, le style d'apprentissage d'un individu fonctionne comme un "filtre à input" et exerce, de ce fait, une influence considérable sur le processus d'apprentissage de la langue étrangère et sur le niveau de performance atteint par les différents types d'apprenants. Cette conception des styles d'apprentissage conduit naturellement à supposer que l'enseignement optimal d'une langue étrangère est celui dont la méthodologie est en adéquation avec le style d'apprentissage des élèves. Selon G. Simons, il convient d'aborder ce type de recherche avec la plus grande prudence si on ne veut pas qu'elle devienne un miroir aux alouettes, un de plus. Pour éviter ce piège, G. Simons analyse quelques problèmes sous-jacents à ce domaine de recherche et tente d'y apporter des solutions. [less ▲]

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See detailTreatment of Excessive Mediastinal Bleeding after Cardiopulmonary Bypass
Hartstein, Gary ULg; Janssens, Marc ULg

in Annals of Thoracic Surgery (1996), 62(6), 1951-4

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective ... [more ▼]

BACKGROUND: Excessive mediastinal bleeding after cardiopulmonary bypass is one of the most frequently reported complications of cardiac operations. Appropriate treatment requires a rapid and effective diagnostic work-up, based on the knowledge of the pathophysiology induced by cardiopulmonary bypass. METHODS: Possible causes, diagnostic methods available, and therapeutic approaches are reviewed in the light of the literature published on excessive bleeding after cardiac operations. RESULTS: When bleeding is massive (> 250 to 300 mL/h for the first 2 hours, > 150 mL/h thereafter), immediate surgical reexploration is mandatory. When bleeding is less important (50 to 150 mL/h), the decision to reoperate should be based on the presence of hemodynamic compromise or a suspected surgical cause. Otherwise, coagulation testing should allow the correction of hemostatic defects as appropriate with protamine, platelet concentrates, fresh frozen plasma, desmopressin, or antifibrinolytics. Hypothermia and hypotension should be corrected and a trial of positive end-expiratory pressure may be considered if diffuse mediastinal oozing (especially from the bed of the mammary artery) is suspected. CONCLUSIONS: A protocol is suggested to guide treatment, taking into account the rapidity of blood loss and the suspected underlying cause. [less ▲]

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See detailBeta-Carbolines Induce Apoptotic Death of Cerebellar Granule Neurones in Culture
Malgrange, Brigitte ULg; Rigo, Jean-Marie ULg; Coucke, Paul et al

in Neuroreport (1996), 7(18), 3041-5

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n ... [more ▼]

Apart from its role in fast inhibitory transmission, only neurotrophic effects have been reported following activation of the GABAA receptor. Here, we show that n-butyl-beta-carboline-3-carboxylate and n-methyl-beta-carboline-3-carboxamide, which are negative allosteric modulators of the GABAA receptor acting at the benzodiazepine site, are neurotoxic for cerebellar granule neurones in culture. The beta-carboline-induced neuronal death is apoptotic since DNA internucleosomal fragmentation was induced and the neurotoxicity could be prevented by inhibitors of mRNA or protein synthesis. As GABA and benzodiazepine ligands (diazepam and Ro 15-1788) protect cerebellar granule cells against beta-carboline-induced toxicity, these data raise the possibility that the interaction between the beta-carbolines and the GABAA receptor is the triggering event leading to neuronal apoptosis. [less ▲]

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See detailGrowth of Cayley and diluted Cayley trees with two kinds of entities
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Journal of Physics : A Mathematical & General (1996), 29(22), 7089-7104

A kinetic growth model derived from the magnetic Eden model is introduced in order to simulate the growth of hierarchical structures, such as Cayley trees. We only consider the case where two kinds of ... [more ▼]

A kinetic growth model derived from the magnetic Eden model is introduced in order to simulate the growth of hierarchical structures, such as Cayley trees. We only consider the case where two kinds of entities are competing with each other can be further subjected to an external field. The very relevant case in which both kinds of entities have different coordination numbers is introduced here for the first time, and is called the diluted Cayley tree. Physical and geometrical properties of the finite and infinite trees are exactly found and simulated. Finite-size effects are emphasized and illustrated on the global or local magnetization and on the chemical activity. Asymptotic limits are given in each case. The generated patterns can be related to a correlated percolation problem briefly discussed in the appendix. [less ▲]

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See detailDecrease of Plasma Vitamin E (Alpha-Tocopherol) Levels in Patients with Abdominal Aortic Aneurysm
Sakalihasan, Natzi ULg; Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Annals of the New York Academy of Sciences (1996), 800

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See detailCytokine Production by Human Thymic Epithelial Cells: Control by the Immune Recognition of the Neurohypophysial Self-Antigen
Martens, Henri ULg; Malgrange, Brigitte ULg; Robert, F. et al

in Regulatory Peptides (1996), 67(1), 39-45

Oxytocin (OT) has been shown to be the dominant peptide of the neurohypophysial family expressed by thymic epithelial and nurse cells (TEC/TNC) in various species. Thymic OT is not secreted but, after ... [more ▼]

Oxytocin (OT) has been shown to be the dominant peptide of the neurohypophysial family expressed by thymic epithelial and nurse cells (TEC/TNC) in various species. Thymic OT is not secreted but, after translocation of a hybrid neurophysin/MHC class I protein, is integrated within the plasma membrane of TEC, thus allowing its presentation to pre-T cells. In order to further demonstrate that thymic OT behaves like a membrane antigen, we assessed the effect of mAbs to OT on cytokine productions by cultures enriched in human TEC. 75-85% pure TEC cultures were prepared from human thymic fragments. Using immunofluorescence and confocal microscopy, ir-OT, ir-interleukin-1 beta (IL-1 beta), ir-interleukin-6 (IL-6) and ir-leukemia inhibitory factor (LIF) could be detected in these TEC cultures. ir-OT was restricted to TEC, while some ir-IL-6 and ir-LIF were also seen in occasional fibroblasts. In basal conditions, ir-IL-6 and ir-LIF (but not ir-OT and ir-IL-1 beta) were detected in the supernatants of human TEC cultures. MAbs to OT induced a marked increase of ir-IL-6 and ir-LIF secretion in TEC cultures. No significant effect was observed using mAbs against vasopressin, mouse immunoglobulins, or control ascitic fluid controls. These data show that OT is fully processed and recognized by specific mAbs at the outer surface of TEC plasma membrane. They further support that thymic OT behaves as the self-antigen of the neurohypophysial family. [less ▲]

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See detailTrypsin and Trypsinogen from an Antarctic Fish: Molecular Basis of Cold Adaptation
Genicot, S.; Rentier-Delrue, Françoise ULg; Edwards, D. et al

in Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology (1996), 1298(1), 45-57

Trypsin from Antarctic fish Paranotothenia magellanica displays molecular and kinetic properties typical of enzymes produced by psychrophilic organisms. The enzyme has a high catalytic efficiency at low ... [more ▼]

Trypsin from Antarctic fish Paranotothenia magellanica displays molecular and kinetic properties typical of enzymes produced by psychrophilic organisms. The enzyme has a high catalytic efficiency at low and moderate temperatures and is rapidly inactivated at temperatures higher than 30 degrees C. The nucleotide sequence was determined after mRNA extraction and cDNA synthesis. The cDNA encodes a pretrypsinogen which includes a seven residue activation peptide containing only three acidic residues preceeding the 222 amino-acid mature enzyme. A three-dimensional model of the enzyme was built. Structural parameters possibly involved in the adaptation to cold have been derived from comparison with the three-dimensional structure of the bovine enzyme. Among them are the lack of Tyr-151 in the substrate binding pocket, an overall decrease in the number of salt bridges and hydrophobicity and the increase in the surface hydrophilicity. [less ▲]

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See detailProtein Kinase- and Staurosporine-Dependent Induction of Neurite Outgrowth and Plasminogen Activator Activity in Pc12 Cells
Leprince, Pierre ULg; Bonvoisin, Catherine ULg; Rogister, Bernard ULg et al

in Biochemical Pharmacology (1996), 52(9), 1399-405

We analysed how interactions between protein kinase-dependent intracellular signalling pathways were implicated in the control of the production of tissue-type plasminogen activator (tPA) and the ... [more ▼]

We analysed how interactions between protein kinase-dependent intracellular signalling pathways were implicated in the control of the production of tissue-type plasminogen activator (tPA) and the generation of neurite outgrowth by PC12 cells. To that aim, cells were treated with agents that interact with the trk receptor and with protein kinases A and C. Nerve growth factor induced only the formation of large neurites. The release of the protease and the production of short neurite outgrowth were found to be protein-kinase-A-dependent events that could be enhanced by simultaneous activation of protein kinase C with phorbol ester. At high concentration, staurosporine, a nonselective inhibitor of protein kinases, induced the production of short neurites and mimicked the protein-kinase-A-dependent effect on tPA release. Such a response was not observed with K-252a, an analogue of staurosporine devoid of neurite-outgrowth-promoting activity. The responses to protein kinase A stimulation and the addition of staurosporine, although similar, seemed to occur through an activation of distinct, yet interacting, signalling pathways. In conclusion, tPA release and large neurite outgrowth from PC12 cells are controlled by parallel, albeit interacting, pathways, suggesting that these two potentially antagonistic events in PC12 cell differentiation can be modulated in a concerted way or independently of each other, depending on the activity of several protein kinases. [less ▲]

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See detailEvidence of involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
Johnson, Robert; Kovvali, G.; Guzder, Sami et al

in Journal of Biological Chemistry (1996), 271(45), 27897-90

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See detailNt-3 Has a Tropic Effect on Process Outgrowth by Postnatal Auditory Neurones in Vitro
Malgrange, Brigitte ULg; Lefebvre, P. P.; Martin, Didier ULg et al

in Neuroreport (1996), 7(15-17), 2495-9

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted ... [more ▼]

CONFOCAL analysis of early postnatal auditory neurones in a bicompartmental culture system was used to test for chemoattractant properties of NGF, BDNF and NT-3 on neuronal process outgrowth. NT-3 exerted a strong tropic effect on neuritic outgrowth from auditory neurones in this system. BDNF and NGF did not have any tropic activity that directed processes outgrowth from auditory neurones. However, BDNF was important for the support of neuronal survival in NGF-treated cultures and for neuritogenesis in NT-3-treated cultures. Since NT-3 has been identified as both a survival factor and a chemotropic agent for auditory neurones, it is likely that this neurotrophin will be a useful therapeutic agent in the treatment of damaged cochleae for the recovery of hearing. [less ▲]

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See detailSynthesis and properties of poly[isobornyl methacrylate (IBMA)-b-butadiene (BD)-b-IBMA] copolymers : new thermoplastic elastomers of a large service temperature range
Yu, Jian Ming; Dubois, Philippe ULg; Jérôme, Robert ULg

in Macromolecules (1996), 29(16), 7316-7332

Anionic polymerization of isobornyl methacrylate (IBMA) has been studied in THF and toluene in a temperature range from −78 to +40 °C by using (1,1-diphenyl-3,3-dimethylbutyl)lithium (DDBLi) as an ... [more ▼]

Anionic polymerization of isobornyl methacrylate (IBMA) has been studied in THF and toluene in a temperature range from −78 to +40 °C by using (1,1-diphenyl-3,3-dimethylbutyl)lithium (DDBLi) as an initiator in the presence of LiCl or not. Effect of solvent and polymerization temperature on tacticity has been studied. The reactivity of IBMA is comparable to tert-butyl methacrylate (tBMA), and polymers of a very narrow molecular weight distribution (<1.10) have been synthesized at room temperature, in THF, in the presence of LiCl. The Tg of PIBMA is found to vary from 170 to 206 °C with chain tacticity. Poly(isobornyl methacrylate) (PIBMA)−polybutadiene (PBD)−PIBMA triblock copolymers have been synthesized by using the m-diisopropenylbenzene (m-DIB)/tert-butyllithium (t-BuLi) diadduct as an initiator. The PBD midblock has been prepared in a cyclohexane/diethyl ether (100/6, v/v) mixture at room temperature. THF has been added [cyclohexane/diethyl ether/THF (100/6/100, v/v/v)] before the IBMA polymerization takes place at either −78 or +25 °C. Triblock copolymers of a very narrow molecular weight distribution (1.10) have been synthesized even at 25 °C, and no gel formation has been observed. These new triblock copolymers exhibit high tensile strength (30 MPa), high ultimate elongation (1000%), and high upper service temperature (160 °C). [less ▲]

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