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See detailSite-directed mutagenesis studies of the hypoxia-inducible factor-1alpha DNA-binding domain.
Michel, Gaetan; Minet, Emmanuel; Mottet, Denis ULg et al

in Biochimica et Biophysica Acta (2002), 1578(1-3), 73-83

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor, is activated when cells are exposed to hypoxia. It is composed of two subunits, HIF-1alpha and ARNT. When activated, it binds to ... [more ▼]

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor, is activated when cells are exposed to hypoxia. It is composed of two subunits, HIF-1alpha and ARNT. When activated, it binds to the hypoxia-responsive element (HRE) and up-regulates the expression of several genes (vascular endothelial growth factor (VEGF), erythropoietin (EPO), enolase, em leader ). By molecular modeling, a 3-D model for the complex between the DNA-binding domain of HIF-1 (bHLH domain) and its consensus DNA sequence has been developed. Specific interactions between three amino acids (Ser22, Ala25, Arg30) of the HIF-1alpha subunit and DNA bases were identified. In order to further investigate the role of these amino acids, we generated four mutants of the HIF-1alpha subunit using site-directed mutagenesis. The activity of each mutant was tested using a reporter gene containing either 6 HRE sequences or the authentic human VEGF promoter. The results show that three mutants, Ala25Ser, Ala26Glu and Arg30Ala, were no longer active in the reporter gene assay. On the other hand, the Ser22Ala mutant increased the reporter gene expression, in normoxia as well as in hypoxia. These results correlate with the ones obtained when the DNA-binding capability of the mutants was assayed by electrophoretic mobility shift assays (EMSA): Arg30Ala and Ala26Glu mutants bind very weakly to HRE while the Ser22Ala mutant has the same binding capacity as the wild-type HIF-1alpha. These results bring new insights on the specificity of the protein/DNA interactions for HIF-1 towards HRE. [less ▲]

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See detailRetrospective comparison of CD34-selected allogeneic peripheral blood stem cell transplantation followed by CD8-depleted donor lymphocyte infusions with unmanipulated bone marrow transplantation.
Baron, Frédéric ULg; Baudoux, Etienne ULg; Fillet, Georges ULg et al

in Hematology (2002), 7(3), 137-43

We have previously reported the feasibility of allogeneic CD34-selected PBSC transplantation followed by pre-emptive CD8-depleted DLI (study group). In this report, we retrospectively compare the clinical ... [more ▼]

We have previously reported the feasibility of allogeneic CD34-selected PBSC transplantation followed by pre-emptive CD8-depleted DLI (study group). In this report, we retrospectively compare the clinical outcome of the 24 patients included in this study with an historical group of 35 patients receiving unmanipulated marrow (BMT group). Patients in the study group had significantly faster neutrophil and platelet recovery and were discharged earlier than BMT patients. The actuarial 150-day (after DLI) probability of developing grade II-IV acute GVHD was 28% for the study group versus 62% for the BMT group (p=0.002). The actuarial 2-year probability of developing chronic GVHD was similar (37 versus 36% (NS)) but chronic GVHD was significantly delayed in the study group (p=0.003). The actuarial 2-year probability of relapse was 30% in the study group versus 33% in the BMT group (NS). The actuarial 2-year probability of survival was 45% in the study group versus 43% in the BMT group (NS). We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to confirm these results. [less ▲]

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See detailRetrosynthetic analysis of fullerene C-60: structure, stereochemistry and calculated stability of C-30 fragments
Geneste, Florence; Moradpour, Alec; Dive, Georges ULg et al

in Journal of Organic Chemistry (2002), 67(2), 605-607

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See detailInternational forum. Use of umbilical cord blood progenitor cells as an alternative for bone marrow transplantation.
Engelfriet, C. P.; Reesink, H. W.; Wagner, J. E. et al

in Vox Sanguinis (2002), 83(2), 172-87

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See detailThe 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin.
Sauvage, Eric ULg; Kerff, Frédéric ULg; Fonze, E. et al

in Cellular and Molecular Life Sciences : CMLS (2002), 59(7), 1223-32

Penicillin-binding proteins (PBPs) are membrane proteins involved in the final stages of peptidoglycan synthesis and represent the targets of beta-lactam antibiotics. Enterococci are naturally resistant ... [more ▼]

Penicillin-binding proteins (PBPs) are membrane proteins involved in the final stages of peptidoglycan synthesis and represent the targets of beta-lactam antibiotics. Enterococci are naturally resistant to these antibiotics because they produce a PBP, named PBP5fm in Enterococcus faecium, with low-level affinity for beta-lactams. We report here the crystal structure of the acyl-enzyme complex of PBP5fm with benzylpenicillin at a resolution of 2.4 A. A characteristic of the active site, which distinguishes PBP5fm from other PBPs of known structure, is the topology of the loop 451-465 defining the left edge of the cavity. The residue Arg464, involved in a salt bridge with the residue Asp481, confers a greater rigidity to the PBP5fm active site. In addition, the presence of the Val465 residue, which points into the active site, reducing its accessibility, could account for the low affinity of PBP5fm for beta-lactam. This loop is common to PBPs of low affinity, such as PBP2a from Staphylococcus aureus and PBP3 from Bacillus subtilis. Moreover, the insertion of a serine after residue 466 in the most resistant strains underlines even more the determining role of this loop in the recognition of the substrates. [less ▲]

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See detailA set of primers for amplification of mitochondrial DNA in Picea abies and other conifer species.
Jeandroz, S.; Bastien, D.; Chandelier, A. et al

in Molecular Ecology Notes (2002), 2

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See detailPurification and characterization of a microbial dehydrogenase - A vanillin : NAD(P)(+) oxidoreductase
Bare, G.; Swiatkowski, T.; Moukil, A. et al

in Applied Biochemistry and Biotechnology (2002), 98-100(Spring), 415-428

Pseudomonas fluorescens (strain BTP9) was found to have at least two NAD(P)-dependent vanillin dehydrogenases: one is induced by vanillin, and the other is constitutive. The constitutive enzyme was ... [more ▼]

Pseudomonas fluorescens (strain BTP9) was found to have at least two NAD(P)-dependent vanillin dehydrogenases: one is induced by vanillin, and the other is constitutive. The constitutive enzyme was purified by ammonium sulfate fractionation, gel-filtration, and Q-Sepharose chromatography. The subunit Mr value was 55,000, determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis. The native M, value estimated by gel-filtration chromatography gave a value of 210,000. The enzyme made use of NAD(+) less effectively than NADP(+). Benzaldehyde, 4-hydroxybenzaldehyde, hexanal, and acetaldehyde were not oxidized at detectable rates in the presence of NAD(+) or NADP(+). The ultraviolet absorption spectrum indicated that there is no cofactor or prosthetic group bound. The vanillin oxidation reaction was essentially irreversible. The pH optimum was 9.5 and the pI of the enzyme was 4.9. Enzyme activity was not affected when assayed in the presence of salts, except FeCl2. The enzyme was inhibited by the thiol-blocking reagents 4-chloromercuribenzoate and N-ethylmaleimide. NAD(+) and NADP(+) protected the enzyme against such a type of inhibition along with vanillin to a lesser extent. The enzyme exhibited esterase activity with 4-nitrophenyl acetate as substrate and was activated by low concentrations of NAD(+) or NADP(+). We compared the properties of the enzyme with those of some well-characterized microbial benzaldehyde dehydrogenases. [less ▲]

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See detailOude modernen. Thomas Vaessens over Nijhoff en Van Ostaijen
Spinoy, Erik ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2002), 118(3), 241-254

This article is a critical response to Thomas Vaessens' book Circus Dubio en Schroom

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See detailLa "compensation forfaitaire" au profit de la presse écrite : le choc des interprétations
Rosoux, Géraldine ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

The article analyzes a decision of the Belgian constitutional Court interpreting a mechanism of compensation, created to ensure the freedom of press: this compensation is not a tax.

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See detailChanging pattern of bacterial susceptibility to antibiotics in hematopoietic stem cell transplant recipients.
Frere, Pascale ULg; Hermanne, J.-P.; Debouge, M.-H. et al

in Bone Marrow Transplantation (2002), 29(7), 589-94

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to ... [more ▼]

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to antibiotics in 492 patients (198 allografts and 294 autografts) transplanted between 1982 and 1999 and evaluated whether ciprofloxacin prophylaxis and an empirical antibiotic regimen (glycopeptide + third-generation cephalosporin) were still valid. We collected all susceptibility tests performed during the initial hospitalization on blood cultures as well as routine surveillance cultures and analyzed susceptibility to ciprofloxacin and to major antibiotics used in our unit. Gram-positive cocci rapidly became resistant to ciprofloxacin (susceptibility around 70% in 1990 to less than 20% in 1998) but sensitivity to glycopeptides remained unaltered. There was a rapid decline in the number of patients colonized with Gram-negative bacilli in the early years of ciprofloxacin prophylaxis. However, susceptibility to ciprofloxacin fell sharply from around 90% in 1990 to around 30% in 1999. In parallel, susceptibility to ceftazidime also decreased to less than 80% in recent years. Piperacillin (+/- tazobactam) did not show any variation over time and its efficacy remained too low (about 60%). Imipenem as well as recently introduced cefepim and meropenem showed stable and excellent profiles (>90% susceptibility). In conclusion: (1) quinolone prophylaxis has now lost most of its value; (2) the choice of a third-generation cephalosporin for empirical antibiotic therapy may no longer be the best because of the emergence of Gram-negative strains resistant to beta-lactamases, such as Enterobacter sp. More appropriate regimens of empirical antibiotic therapy in HSCT recipients may be based on the use of a carbapenem or fourth-generation cephalosporin. [less ▲]

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See detailPoesia dell’alto medioevo europeo : manoscritti, lingua e musica dei ritmi latini
Moreno, Paola ULg

in Scriptorium (2002), 267

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See detailNonmyeloablative allogeneic hematopoietic stem cell transplantation.
Baron, Frédéric ULg; Beguin, Yves ULg

in Journal of Hematotherapy & Stem Cell Research (2002), 11(2), 243-63

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols (nonmyeloablative stem cell transplantation or NMSCT) based on a two-step approach: first, the use of immunosuppressive (but nonmyeloablative) preparative regimens providing sufficient immunosuppression to achieve engraftment of allogeneic hematopoietic stem cells and, in a second step, destruction of malignant cells by the GVL effect. Preliminary results showed that NMSCT were feasible with a relatively low transplant-related mortality (TRM), even in patients older than 65 years. In addition, strong antitumor responses were observed in several hematological malignancies as well as in some patients with renal cell carcinoma. After discussing the mechanisms and efficacy of the GVL effect as well as the rationale for NMSCT strategies, this article reviews the first results of ongoing clinical trials. Innovative modalities that may permit amplification of the GVL effect while minimizing the risk of GVHD are discussed. Because the benefits of NMSCT over alternative forms of treatment remain to be demonstrated, this strategy should be restricted to patients included in clinical trials. [less ▲]

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See detailCharacterization of porous texture of hyperporous materials by mercury porosimetry using densification equation
Pirard, René ULg; Alié, Christelle ULg; Pirard, Jean-Paul ULg

in Powder Technology (2002), 128(2-3), 242-247

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury ... [more ▼]

The purpose of this paper is to propose a method of analyzing the mercury porosimetry data in the case of materials called hyperporous. This class of material does not undergo intrusion by mercury; instead, it shrinks under the mercury isostatic pressure and its density increases. The phenomenon is partially or completely irreversible. The proposed method enables computing the pore volume distribution as a function of the pore size in the same way as Washburn's method does in the case of mercury intrusion. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailActualités thérapeutiques des céphalées trigéminales autonomes.
Vandenheede, Michel; MAERTENS DE NOORDHOUT, Alain ULg

in Médecine et Hygiène (2002)

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See detailAcamprosate reduces context-dependent ethanol effects
Quertemont, Etienne ULg; Brabant, Christian ULg; De Witte, Philippe

in Psychopharmacology (2002), 164(1), 10-18

Rationale: Previous studies have indicated that the conditioned effects of environmental stimuli contribute to ethanol tolerance and abuse. Acamprosate was recently suggested to reduce the effects of ... [more ▼]

Rationale: Previous studies have indicated that the conditioned effects of environmental stimuli contribute to ethanol tolerance and abuse. Acamprosate was recently suggested to reduce the effects of environmental stimuli previously associated with ethanol administrations. This action is believed to contribute to the clinical benefits of acamprosate treatment in alcoholics. Objectives: In the present experiment, a classical drug-conditioning paradigm was used to test whether acamprosate modulates the effects of ethanol-paired environmental stimuli on spontaneous motor activity. Methods: Wistar rats were divided into three groups: cued, uncued and control. The cued group daily received ethanol injections (2.0 g/kg, IP) in a specific testing environment. The uncued group daily received ethanol injections (2.0 g/kg, IP) in their home cage but never experienced ethanol in the testing environment. The control group was injected with saline and never experienced ethanol. After 8 conditioning days, the rats were IP injected with various ethanol doses (saline, 1.0, 1.5 or 2.0 g/kg) and their spontaneous motor activity in the testing environment was recorded to investigate their respective tolerance to ethanol inhibitory effects. In the second part of the study, the same procedure was repeated with chronically acamprosate-treated rats. The chronic acamprosate treatment (400 mg/kg per day) started 2 weeks before the conditioning procedure by diluting acamprosate in the drinking bottles and was maintained throughout the whole experiment. Results: The cued rats showed a significant environment-dependent tolerance to ethanol inhibitory effects relative to the uncued and control rats. This higher ethanol tolerance of the cued rats was mainly due to a faster recovery from ethanol's inhibitory effects on spontaneous activity. Furthermore, the cued rats showed a higher level of activity in the testing environment after the saline injection. However, it is not clear whether this hyperactivity is a conditioned compensatory response or an increased exploratory behavior. Acamprosate totally abolished the environment-dependent tolerance to ethanol, whereas it did not alter the hyperactivity of the cued rats in the testing environment. Conclusions: The results of the present study suggest that acamprosate reduces ethanol-conditioned effects. Such an action may be of importance to explain the anti-relapse effects of acamprosate. [less ▲]

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See detailCaractérisation mécanique et chimique des surfaces et interfaces polymères par microscopies de force atomique
Cuenot, Stéphane; Duwez, Anne-Sophie ULg; Martin, Philippe et al

in Chimie Nouvelle (2002), 20

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See detailPositive effects of glucocorticoids on T cell function by upregulation of interleukin-7 receptor alpha
Franchimont, Denis; Galon, Jérôme; Vacchio, Melanie S. et al

in Journal of Immunology (2002), 168

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See detailDoes the P(2X1del) variant lacking 17 amino acids in its extracellular domain represent a relevant functional ion channel in platelets?
Oury, Cécile ULg; Toth-Zsamboki, Emese; Vermylen, Jos et al

in Blood (2002)

In this letter, we questionned the existence of a ADP responsive P2X1 protein variant in platelets.

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See detailThe role of the main silica precursor and the additive in the preparation, of low-density xerogels
Alié, Christelle ULg; Pirard, René ULg; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (2002), 311(3), 304-313

The incorporation of an additive during sol-gel synthesis reduces shinkage during ambient drying. The following additives have been studied: 3-,(2-aminoethylamino)propyltrimethoxysilane (EDAS), 3 ... [more ▼]

The incorporation of an additive during sol-gel synthesis reduces shinkage during ambient drying. The following additives have been studied: 3-,(2-aminoethylamino)propyltrimethoxysilane (EDAS), 3-aminopropyltriethoxysilane (AES) and 3-(2-aminoethylamino)propyltriethoxysilane (EDAES) and the main silica precursors were tetraethylorthosilicate (TEOS) and tetrapropylorthosilicate (TPOS). When the additive contains methoxy groups (EDAS), it acts as a nucleation agent of the silica particles and exactly the same properties (pore volume, specific surface area, particle and aggregate size) are obtained whether the main reagent is TEOS or TPOS. The nucleation mechanism is based on the difference in reactivity between additive and main reagent. In case of nucleation by the additive, the nucleation agent fixes the properties whatever the main silica precursor is. When both the additive and the main reagent contain ethoxy groups (series AES-TEOS and EDAES-TEOS), there is no nucleation mechanism by the additive, and the silica particle size remains nearly constant. With less reactive main reagent (series AES-TPOS and EDAES-TPOS), pore volumes up to 17 cm(3)/g have been obtained with pore sizes up to nearly 10 pm and very big particles (similar to100 nm). The absence of nucleation by the additive for the couples AES-TPOS and EDAES-TPOS could be due to the fact that the difference in reactivity between ethoxy groups and propoxy groups is not sufficient to initiate the nucleation mechanism by the additive. In the absence of nucleation by the additive, the main reagent plays a role: highly porous materials with very large p. ores are prepared with TPOS. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailThymus, central T cell self-tolerance and type 1 diabetes
Geenen, Vincent ULg

in International Diabetes Monitor (2002), 14

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See detailAn Immunologic investigation of canine eosinophilic bronchopneumopathy.
Clercx, Cécile ULg; Peeters, Dominique ULg; German, Alex et al

in Journal of Veterinary Internal Medicine (2002), 16

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See detailStaalname van de hersenstam voor TSE-Onderzoek bij het schaap
Jacobs, C.; Gabriel, Annick ULg; Simoens, P.

in Vlaams Diergeneeskundig Tijdschrift (2002), 71

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See detailMolecular and pigment studies of the picophytoplankton in a region of the Southern Ocean (42-54 degrees S, 141-144 degrees E) in March 1998
Wilmotte, Annick ULg; Demonceau, Caroline; Goffart, Anne ULg et al

in Deep-Sea Research Part II, Topical Studies in Oceanography (2002), 49(16), 3351-3363

Seven filtered seawater samples (depths between 30 and 55 m) collected during the SAZ project of the Austral summer of 1997-1998 were used for a simultaneous study of the picophytoplankton pigments based ... [more ▼]

Seven filtered seawater samples (depths between 30 and 55 m) collected during the SAZ project of the Austral summer of 1997-1998 were used for a simultaneous study of the picophytoplankton pigments based on high-performance liquid chromatography (HPLC) analyses and flow cytometry, and of the molecular diversity of the picophytoplankton based on their rDNA sequences. The sampling sites could be divided into three temperature zones, distinguished by their proximity to the Sub-Antarctic and Polar Fronts. HPLC analysis of total chlorophylls and carotenoids showed fairly low phytoplankton concentrations (77-262 ng chl al(-1)), with minimal values of the pigments in the two samples of the Polar Front Zone around 54degreesS (water temperature of 4degreesC at time of collection). In this zone, a similar decrease of particles, identified as cyanobacteria on the basis of their fluorescence, was observed by flow cytometry. Sequences very similar to the 16S rDNA sequence of Synechococcus WH8103 were present in all samples. This Synechococcus genotype is thus found in the Southern Ocean in addition to the Atlantic and Pacific locations where it has been previously observed. The yield of PCR products was lower in the two samples taken in the Polar Front Zone, showing a good agreement between molecular and pigment data. 16S rDNA sequences of plastids of eukaryotic algae also were retrieved, mostly related to those of an environmental clone called OM164, which has not been cultivated but has phylogenetic affinities to the Raphidophyceae. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailLes lectures obligatoires en 5e année de l'enseignement secondaire de transition en Communauté française de Belgique
Lafontaine, Dominique ULg

in Enjeux : Revue de Formation Continuée et de Didactique du Français (2002), 55

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See detailDistribution of surface carbon dioxide and air-sea exchange in the upwelling system off the Galician coast
Borges, Alberto ULg; Frankignoulle, Michel

in Global Biogeochemical Cycles (2002), 16

Data on the distribution of the partial pressure of CO2 (pCO2) were obtained during six cruises off the Galician coast, a region characterized by a seasonal upwelling. The values of pCO2 over the ... [more ▼]

Data on the distribution of the partial pressure of CO2 (pCO2) were obtained during six cruises off the Galician coast, a region characterized by a seasonal upwelling. The values of pCO2 over the continental shelf are highly variable and range between 265 and 415 matm during the upwelling season and between 315 and 345 matm during the downwelling season. Both the continental shelf and off-shelf waters behave as significant net sinks of atmospheric CO2. The computation of the air-sea fluxes of CO2 over the continental shelf yields a net influx in the range of 2.3 (±0.6) to 4.7 (±1.0) mmol C m 2 d 1 during the upwelling season and 3.5 (±0.8) to 7.0 (±1.5) mmol C m 2 d 1 on an annual basis. During the upwelling season and on an annual basis, although the observed air-sea gradients of CO2 over the continental shelf are significantly stronger than those in off-shelf waters, the computed air-sea CO2 fluxes are not significantly different because of the important incertitude introduced in the calculations by the estimated error on wind speed measurements. The presence of upwelling filaments increases the influx of atmospheric CO2 in the off-shelf waters. During summer, important short-term variations of pCO2 are observed that are related to both upwelling and temperature variations. During winter the cooling of water causes important undersaturation of CO2 related to the effect of temperature on the dissolved inorganic carbon equilibrium constants. [less ▲]

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See detailBiometrological assessment of skin protectors against moderate cold threat.
Claes, Geert; Pierard, Gérald ULg

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : Cold injuries represent a serious problem in winter sport practice and other outdoor activities. Some protection is expected to be achieved by specific topical preparations aiming at ... [more ▼]

Background : Cold injuries represent a serious problem in winter sport practice and other outdoor activities. Some protection is expected to be achieved by specific topical preparations aiming at decreasing heat loss by water evaporation from the skin. Objective : To compare the efficacy of 6 topical formulations enriched or not in rubefacients. The role of the vehicle was also assessed. Methods : A total of 30 trained cyclists tested the products on their forearms. The skin temperature and electrometric values were recorded at baseline following applications of the test products, and after 30 min-bicycle riding in moderately cold and humid outdoor conditions. Results : At baseline, skin temperature was increased by rubefacients dispersed a lipogel and o/w emulsion. This parameter decreased at all test sites after riding, but the values remained higher at the rubefacient-treated sites compared to the control untreated site. The oil and lipogel formulations achieved partial occlusion decreasing the transepidermal water loss. This effect was maintained after exercise without, however, hindering sweating. Conclusion : Among the presently tested formulations, the rubefacient-enriched lipogels appeared to be the most efficient formulations for maintaining skin temperature in the normal range during sport practice in a moderately cold environment. [less ▲]

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See detailA copula based model for multivariate non normal longitudinal data: analysis of a dose titration safety study on a new antidepressant
Lambert, Philippe ULg; Vandenhende, François

in Statistics in Medicine (2002), 21

A new model for multivariate non-normal longitudinal data is proposed. In a first step, each longitudinal series of data corresponding to a given response is modelled separately using a copula to relate ... [more ▼]

A new model for multivariate non-normal longitudinal data is proposed. In a first step, each longitudinal series of data corresponding to a given response is modelled separately using a copula to relate the marginal distributions of the response at each time of observation. In a second step, at each observation time, the conditional (on the past) distributions of each response are related using another copula describing the relationship between the corresponding variables. Note that there is no need to consider the same family of distributions for these response variables. The technique is illustrated in a dose titration safety study on a new antidepressant. The haemodynamic effect on diastolic blood pressure, systolic blood pressure and heart rate is studied. These three responses are measured repeatedly over time on ten healthy volunteers during the dose escalation. The available covariates are sex and the concentration of drug in the plasma at time of measurement. [less ▲]

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See detailMulticollinearity in prognostic factor analyses using the EORTC QLQ-C30: identification and impact on model selection
Van Steen, Kristel ULg; Curran, D.; Kramer, J. et al

in Statistics in Medicine (2002), 21(24), 3865-3884

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to ... [more ▼]

Clinical and quality of life (QL) variables from an EORTC clinical trial of first line chemotherapy in advanced breast cancer were used in a prognostic factor analysis of survival and response to chemotherapy. For response, different final multivariate models were obtained from forward and backward selection methods, suggesting a disconcerting instability. Quality of life was measured using the EORTC QLQ-C30 questionnaire completed by patients. Subscales on the questionnaire are known to be highly correlated, and therefore it was hypothesized that multicollinearity contributed to model instability. A correlation matrix indicated that global QL was highly correlated with 7 out of 11 variables. In a first attempt to explore multicollinearity, we used global QL as dependent variable in a regression model with other QL subscales as predictors. Afterwards, standard diagnostic tests for multicollinearity were performed. An exploratory principal components analysis and factor analysis of the QL subscales identified at most three important components and indicated that inclusion of global QL made minimal difference to the loadings on each component. suggesting that it is redundant in the model, In a second approach, we advocate a bootstrap technique to assess the stability of the models. Based on these analyses and since global QL exacerbates problems of multicollinearity, we therefore recommend that global QL be excluded from prognostic factor analyses using the QLQ-C30. The prognostic factor analysis was rerun without global QL in the model, and selected the same significant prognostic factors as before. Copyright (C) 2002 John Wiley Sons, Ltd. [less ▲]

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See detailBestiaire et métamorphoses d’Eugène Savitzkaya
Demoulin, Laurent ULg

in Ponts/Ponti (2002), 2

Les animaux se croisent par centaines dans les romans de Savitzkaya et leur présence a une valeur symbolique qui est analysée ici.

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See detailGlutathione S-transferase isoenzymes in the two-spot ladybird, Adalia bipunctata (Coleoptera: Coccinellidae).
Francis, Frédéric ULg; Haubruge, Eric ULg; Dierickx, Paul

in Archives of Insect Biochemistry and Physiology (2002), 49(3), 158-66

Isoenzymes of glutathione S-transferase (GST) in adult Adalia bipunctata, an aphidophagous predator, were studied. Cytosolic GST activity was studied in each beetle developmental stage. The highest ... [more ▼]

Isoenzymes of glutathione S-transferase (GST) in adult Adalia bipunctata, an aphidophagous predator, were studied. Cytosolic GST activity was studied in each beetle developmental stage. The highest activities towards both 1-chloro-2,4-dinitrobenzene (CDNB) and 2,4-dinitro-1-iodobenzene (DNIB) occurred in adults. The enzyme distribution was investigated in adults. While most of the enzymatic activity was found in the abdomen (40-50 and 34-63% respectively) using several concentrations of both CDNB and DNIB, significant differences were observed for the head and the thorax depending on the substrate. Activities were more abundant in the thorax with DNIB (37-47%) compared to the 13-19% obtained with CDNB. Some GST activity was also detected in the elytra. GSTs were purified by epoxy-activated Sepharose 6B affinity chromatography and applied to an HPLC column to determine the native molecular weight (69 kDa). Three isoenzymes were separated by chromatofocusing at pH ranges 7-4. Three bands with molecular mass from 23 to 26 kDa were visualised on SDS-PAGE. Their isoelectric points were 6.66, 6.36, and 6.21. The substrate specificities and the kinetic parameters (Vm and Km) of the isoenzymes showed large differences depending on the isoenzyme. Arch. [less ▲]

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See detailAre central executive functions working in patients with focal frontal lesions?
Andrès Bénito, P.; Van der Linden, Martial ULg

in Neuropsychologia (2002), 40(7), 835-845

The aim of this study was to examine the hypothesis of a link between frontal cortex and two executive functions in working memory: the capacity to perform a dual task and the ability to inhibit ... [more ▼]

The aim of this study was to examine the hypothesis of a link between frontal cortex and two executive functions in working memory: the capacity to perform a dual task and the ability to inhibit irrelevant information. A dual task designed to assess the capacity to perform storage and processing simultaneously and a directed forgetting task designed to assess the capacity to actively inhibit no-longer relevant information were administered to a group of patients with focal frontal lesions and to a group of control participants. The results revealed that despite showing reduced short-term storage, frontal patients performed the dual task and inhibited the no-longer relevant information as well as control participants. These findings suggest that not all-executive processes are exclusively sustained by the frontal cortex [Quart J Exp Psychol 9 (1996) 5; Curr Opin Neurobiol 10 (2000) 195; Neuropsychology (1994) 544; The Cognitive Neuropsychology of Alzheimer-type dementia. Oxford, New York: Oxford University Press, 1996]. [less ▲]

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See detailScalable adaptive hierarchical clustering
Mathy, Laurent ULg; Canonico, R.; Simpson, S. et al

in IEEE Communications Letters (2002), 6(3), 117--119

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See detailAutoimmunity and pregnancy: Theory and practice
Geenen, Vincent ULg; PERRIER d'HAUTERIVE, Sophie ULg; Puit, M. et al

in Acta Clinica Belgica (2002), 57(6), 317-324

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See detailMR1952249, Kriegsmann, G. A. and Tilley, B. S., Microwave heating of laminate panels; J. Engrg. Math.
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (2002), 44(2), 173--198

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See detailA mixture model to assess the effect of a hormonal stimulation on the development of follicles in prepubertal heifers
Lambert, Philippe ULg

in Journal of the Royal Statistical Society : Series C (Applied Statistics) (2002), 4

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as ... [more ▼]

The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as in post-pubertal heifers: after a few days, a dominant follicle arises on one of the two ovaries whereas the other subordinate follicles regress.The dominant follicle remains detectable when the next wave occurs. The number and the diameters of these follicles have been measured for 14 days.The same experiment was repeated after a 3-day FSH stimulation. Several large follicles now arise simultaneously on both ovaries together with small follicles which cannot be detected any more when the next wave occurs. Unfortunately, follicles were not individually tracked. Therefore a three-component mixture model was used to describe the potential simultaneous observation of dominant, decaying dominant and subordinate follicles before the FSH stimulation; the same type of model was considered for large, decaying large and small follicles after the hormonal stimulation. Moreover, for technical reasons, only follicles larger than 2 mm are observable. Measurements were thus left truncated.The models fitted are used to quantify the effects of the stimulation and to determine the ideal time point at which follicles should be punctured under ultrasonography to harvest ovocytes that will be fertilized and cultured in vitro. [less ▲]

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See detailMR1955178,Park, Hyo-Il , Multivariate percentile tests for incomplete data ; Ann. Inst. Statist. Math.
Rochus, Pierre ULg

in Mathematical Reviews [=MR] (2002), 54(4), 934--944

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See detailLa nuit et le jour. L'être, l'art, l'autre selon Lévinas
Steinmetz, Rudy ULg

in Voir (2002)

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See detailTime-resolved laser spectroscopy of multiply ionized atoms: Natural radiative lifetimes in CeIV
Zhang, Z. G.; Svanberg, S.; Quinet, Pascal ULg et al

in Physical Review Letters (2001), 87(27),

Radiative lifetimes have been measured for two excited levels of Ce IV using the time-resolved laser-induced fluorescence technique. Ce3+ ions were produced in a laser-induced plasma. In the measurements ... [more ▼]

Radiative lifetimes have been measured for two excited levels of Ce IV using the time-resolved laser-induced fluorescence technique. Ce3+ ions were produced in a laser-induced plasma. In the measurements, a suitable magnetic field was applied to reduce the recombination between electrons and the ions and thus the background light from the recombination, and special care was exercised to avoid flight-out-of-view effects on the lifetime measurements for the high-velocity ions. The experimental lifetime results, tau = 30(2) ns for the level 49 737 cm(-1) and tau = 30(3) ns for the level 52 226 cm(-1), were compared with relativistic Hartree-Fock calculations (tau = 30.5 and 30.0 ns) indicating a particularly excellent agreement. [less ▲]

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See detailMeasurement of radiative lifetimes and determination of transition probabilities of astrophysical interest in HoIII
Biémont, Emile ULg; Palmeri, P.; Quinet, Pascal ULg et al

in Monthly Notices of the Royal Astronomical Society (2001), 328(4), 1085-1090

Lifetimes of six levels belonging to the 4f(10)6p configuration of Ho III have been measured for the first time using the time-resolved laser-induced fluorescence method. They are compared with ... [more ▼]

Lifetimes of six levels belonging to the 4f(10)6p configuration of Ho III have been measured for the first time using the time-resolved laser-induced fluorescence method. They are compared with multiconfigurational pseudo-relativistic Hartree-Fock calculations. A very good agreement is found. Using the experimental lifetimes and theoretical branching fractions, a first set of transition probabilities of astrophysical interest has been obtained for this ion. [less ▲]

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See detailFacies architecture and diagenesis of Belgian Late Frasnian carbonate mounds
Boulvain, Frédéric ULg

in Sedimentary Geology (2001), 145(3-4), 269-294

Late Frasnian Petit-Mont Member carbonate mounds occur in the southern pail of the Dinant Synclinorium and in the Philippeville Anticline (SW Belgium). These mounds are 30 to 80 m thick and 100 to 250 m ... [more ▼]

Late Frasnian Petit-Mont Member carbonate mounds occur in the southern pail of the Dinant Synclinorium and in the Philippeville Anticline (SW Belgium). These mounds are 30 to 80 m thick and 100 to 250 m in diameter. They are embedded in shale, nodular shale and argillaceous limestone. Based on facies mapping of 14 buildups and related off-mound sediments, these mounds typically started from below the photic and storm wave base zones and builtup into shallow water environments. Above an argillaceous limestone substrate, the first carbonate mound facies consists of spiculitic wackestone with stromatactis (PM1), which becomes progressively enriched in crinoids and corals (PM2), then in peloids, stromatoporoids and cyanobacteria (PM3). PM4 consists of algal-coral-peloid wackestone and packstone with green algae and thick algal coatings, A core of algal and microbial bindstone (PM5) sporadically occurs within large mounds. The uppermost part of these mounds may show a recurrence of facies PM2 and PM1. PM1 to PM3 are coloured red by hematite derived from microaerophilic iron bacteria; PM4 and PM5 are grey. The transition from the aphotic to the cyanobacterial photic zone is recorded in the succession PM2-PM3; the transition from the cyanobacterial to the green algal photic zone is recorded by PM3-PM5. Storm wave base was reached within PM3 and fair-weather wave base within PM5. This paleobathymetric interpretation suggests a depth of 100-150 in during initial establishment of PM1. Three types of mounds can be distinguished on the basis of geometry and facies architecture: (1) "Les Bulants"-type mounds display a continuous vertical facies succession (PM2-3-4-5) and low relief, (2) although exhibiting the same facies succession as "Les Bulants", "Les Wayons"-type mounds show a distinct relief with steep flanks and bioclastic talus; (3) "St.-Remy" mounds consist exclusively of PM1 and PM2, bioclastic flank deposits are not observed. From (1) to (3), these mound types represent successive deepening down a ramp. Biostratigraphic correlation on a regional scale provides good evidence that relative sea-level changes largely controlled lateral and vertical transitions of facies. Beyond that, hypoxic conditions are indicated by the sponge and iron-bacteria consortium in lower parts of the mounds. This is in agreement with the general assumption of stratified water masses during Late Frasnian, preceding the prominent Lower Kellwasser crisis. Cementation began with a radiaxial synsedimentary cement. A fringe of meteoric phreatic cement, initially nonluminescent, then with a bright orange luminescence, occurs in all mounds. It is contemporaneous with a nonluminescent pervasive cement of grainstones deposited in littoral areas. Differentiation between the (reducing) mounds and the (oxidizing) littoral area resulted from better aquifer circulation in sedimentary bodies close to the recharge area. Late burial cements occlude all the remaining porosity and are contemporaneous with the opening of the Variscan fracture system. (C) 2001 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailComparative effect of hormone replacement therapy on bone mass density and skin tensile properties
Pierard, Gérald ULg; Vanderplaetsen, S.; Pierard-Franchimont, Claudine ULg

in Maturitas (2001), 40(3), 221-227

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare ... [more ▼]

Objectives: connective tissues constitutive of skin and bones are affected during the climacteric. Hormone replacement therapy (HRT) can help mitigate their atrophy. The aim of this study was to compare the HRT effect on the skin tensile properties and bone mass density. Methods: a total of 120 postmenopausal women (60 untreated, 60 receiving HRT) were enrolled in the study. Skin tensile properties were assessed on the volar forearm using a computerized suction device. A 500 mbar suction was applied through a 4-mm diameter hollow probe. Two operating modes were applied using a steep and a progressive Suction, respectively. BMD was measured on the hip, femoral neck and lumbar spine using dual X-ray absorptiometry. Results: in both groups of women skin elasticity was correlated with BMD. HRT significantly reduced the climacteric-associated decline in skin elasticity. A trend in better preserved BMD was also found in these women without, however, reaching significance. Conclusions: it is concluded that measures of the skin tensile properties can be sensitive enough to disclose HRT efficacy upon connective tissue atrophy. Any decrease in skin elasticity during the climacteric should prompt to perform a BMD assessment. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailA novel approach for extracting time-delays from lightcurves of lensed quasar images
Burud, I.; Magain, Pierre ULg; Sohy, Sandrine ULg et al

in Astronomy and Astrophysics (2001), 380

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear ... [more ▼]

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear variation can be included in order to correct for slow long-term microlensing effects in one of the lensed images. An iterative version of the method can be applied in order to correct for higher-order microlensing effects. The method is tested on simulated light curves. When higher-order microlensing effects are present, the time delay is best constrained with the iterative method. Analysis of a published data set for the lensed double Q 0957+561 yields results in agreement with other published estimates. [less ▲]

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See detailSimultaneous Observation of Magnetospheric Neutral Atoms and Proton Aurora
Mende, S. B.; Frey, H. U.; Immel, T. J. et al

in Eos (2001), 42

Data from the High Energy Neutral Atom (ENA) and the far ultraviolet (FUV) imagers on IMAGE were compared for a six hour period during which a reasonably intense substorm occurred. The substorm presented ... [more ▼]

Data from the High Energy Neutral Atom (ENA) and the far ultraviolet (FUV) imagers on IMAGE were compared for a six hour period during which a reasonably intense substorm occurred. The substorm presented is typical of a substorm expansive phase showing that while the total electron precipitation suddenly increase one whole order of magnitude, the protons increase only about 50%. In principle ENA images represent the trapped fluxes in the magnetosphere while the proton aurora measured by the FUV SI12 instrument represents the precipitating component. At substorm onset the increase in intensity of the auroral protons and electrons is very sudden while the intensification of the ENA-s coming from regions of L<6 is much more gradual. The intensification of the precipitating electrons is relatively short lived ( ~ 10 minutes) while the ENA enhancements are long lived (almost a whole hour). Just prior to the substorm expansive phase (in the growth phase) the precipitated proton and electron fluxes encounter a minimum while the ENA-s show a slight growth. [less ▲]

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See detailObservation of the proton aurora with IMAGE FUV imager and simultaneous ion flux in situ measurements
Gérard, Jean-Claude ULg; Hubert, Benoît ULg; Meurant, M. et al

in Journal of Geophysical Research. Space Physics (2001), 106(A12), 28939-28948

The far ultraviolet cameras on board the IMAGE satellite images the aurora in three different spectral regions. One of the channels of the spectrographic imager SI12 observes the Doppler-shifted Lyman ... [more ▼]

The far ultraviolet cameras on board the IMAGE satellite images the aurora in three different spectral regions. One of the channels of the spectrographic imager SI12 observes the Doppler-shifted Lyman alpha emission of precipitating protons. It makes it possible to spectrally discriminate between the proton and electron FUV aurora and to globally map the energetic protons. Its response depends on the auroral Lyman alpha. line shape which reflects the characteristics of the proton pitch angle and energy distributions. We illustrate the dependence of the SI12 count rate on the characteristic energy of the proton precipitation and the viewing geometry. Simultaneous in situ observations of the precipitated protons have been collected during a FAST satellite pass when IMAGE was observing the global north polar region. The premidnight region located at the equatorward boundary of the oval is dominated by proton precipitation with a mean energy E = 7 keV which is separated from the electron component. The prenoon crossing exhibits a softer proton energy spectrum with E = 0.9 keV. The measured proton energy distribution is used as an input to a Monte Carlo model to calculate the expected SI12 signal along the magnetic footprint of the satellite orbit. If the different spatial resolution of the two types of measurements is accounted for, a good quantitative agreement is found with the IMAGE observations. Similarly, ion flux measurements collected on board the Defense Meteorological Satellite Program F15 satellite during an overflight in the postmidnight sector provide good agreement with the SI12 observations at the footprint aurora. The comparisons confirm the reliability of the FUV IMAGE cameras to remotely discriminate between the electron and the proton precipitations. The vertical emission rate profiles of the N-2 Lyman-Birge-Hopfield and O I (1356 Angstrom) emissions are calculated in the proton-dominated premidnight region. It is shown that the protons and the electrons produce FUV emissions with contributions peaking at different altitudes. Excitation by secondary electrons dominates the production of both emissions. [less ▲]

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See detailSpectroscopic monitoring of 10 new northern slowly pulsating B star candidates discovered from the HIPPARCOS mission
Mathias, P.; Aerts, C.; Briquet, Maryline ULg et al

in Astronomy and Astrophysics (2001), 379

A one-year follow-up campaign of high-resolution, high-signal-to-noise spectroscopy for 10 candidate slowly pulsating B stars, which were discovered from the HIPPARCOS astrometric mission, shows that all ... [more ▼]

A one-year follow-up campaign of high-resolution, high-signal-to-noise spectroscopy for 10 candidate slowly pulsating B stars, which were discovered from the HIPPARCOS astrometric mission, shows that all stars exhibit line-profile variability. From our data, and from the HIPPARCOS photometry, we conclude that all but one of the targets provide evidence of multiperiodicity, with periods of the order of days, confirming their pulsational nature. Thus they are confirmed slowly pulsating B stars. We summarize the pulsation periods and Q-values and select the most interesting targets for very-long-term follow-up observations with the goal of performing asteroseismology. Based on observations obtained at the Observatoire de Haute-Provence. [less ▲]

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See detailThe B-type variable HD 131120 modelled by rotational modulation
Briquet, Maryline ULg; De Cat, P.; Aerts, C. et al

in Astronomy and Astrophysics (2001), 380

We present ground-based multi-colour Geneva photometry and high-resolution spectra of the variable B-type star HD 131120. All sets of data reveal a monoperiodic star with a period of 1.569 days. We ... [more ▼]

We present ground-based multi-colour Geneva photometry and high-resolution spectra of the variable B-type star HD 131120. All sets of data reveal a monoperiodic star with a period of 1.569 days. We compare the variability of the star with a non-radial g-mode pulsation model and with a rotational modulation model. The latter model appears to be the best explanation for the observed line-profile variations of the star. Moreover, contrary to the pulsational model, it is able to reproduce the behaviour of the first three moments of the Si and He lines as well as the large variability of their equivalent width. We therefore remove the star from the list of new Slowly Pulsating B stars found from Hipparcos data. Based on observations obtained with the Swiss photometric telescope and ESO's CAT/CES telescope, both situated at La Silla, Chile. [less ▲]

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See detailMetal biogeochemistry in the Tinto-Odiel rivers (Southern Spain) and in the Gulf of Cadiz: a synthesis of the results of TOROS project
Elbaz-Poulichet, Françoise; Braungardt, Chantal; Achterberg, Eric et al

in Continental Shelf Research (2001), 21(18-19), 1961-1973

TOROS (Tinto-Odiel-River-Ocean Study) has been studying the biogeochemical processes which control metals and nutrients cycling in the mixing zone of the Tinto and Odiel rivers (SW Spain) and has ... [more ▼]

TOROS (Tinto-Odiel-River-Ocean Study) has been studying the biogeochemical processes which control metals and nutrients cycling in the mixing zone of the Tinto and Odiel rivers (SW Spain) and has established the fate of metals in the Gulf of Cadiz in relation to hydrodynamics and biological activity. The Tinto and Odiel rivers are small, with a combined mean discharge of 18 m(3)/s. They drain the largest sulphide mineralisation in the world. Predominantly, Zn-Cu-Pb mineralisation has been worked since 2500 yr BC. The estuarine zone includes both an extensive area of salt marsh and an intensively industrialised urban area. As a consequence of pyrite oxidation, the Tinto and Odiel rivers are strongly acidic (pH < 3) with extremely high and variable metal concentrations. Transition metals are poorly removed from the water column in the mixing zone. Moreover, drainage from large phosphogypsum waste deposits contributes to As, Hg, U and phosphate contamination of the estuary. The collapse of the tailing reservoir at los Frailes in 1998 had not impacted the chemistry of the coastal waters up to 6 months later. A large plume of metal-rich waters due to the Tinto arid Odiel discharges occurs along the coast of the Gulf of Cadiz. This plume affects seasonally the Atlantic inflow through the Strait of Gibraltar. The dispersion of the metal discharges has been simulated by injection of a tracer in the 3-D hydrodynamical model. Both model and field study clearly show the inflow of metal contaminated Spanish Shelf Water through the Strait of Gibraltar. (C) 2001 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPrésentation comparative et thématique des politiques de défense des Etats membres de l'UE
Dumoulin, André ULg; Mathieu, Raphaël; Metten, Vincent

in Sécurité et stratégie (2001), (68), 188

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See detailAutonomous Reflectors over Active Networks: Towards Seamless Group Communication
Yamamoto, Lidia; Leduc, Guy ULg

in The Interdisciplinary Journal of Artificial Intelligence & the Simulation of Behavious (AISBJ) (2001), 1(1), 125-146

We present a reflector service that seeks to maintain application-level connectivity in the presence of network-level multicast failures. The service is based on the dynamic deployment of autonomous ... [more ▼]

We present a reflector service that seeks to maintain application-level connectivity in the presence of network-level multicast failures. The service is based on the dynamic deployment of autonomous reflectors modelled as mobile agents on top of an active network infrastructure. It is able to repair multicast tree failures by building a self-organising tree of reflectors, which will be connected to each other via unicast. The scheme is decentralised and takes into account node and link resources to find agent locations that lead to low cost tree configurations. We focus on the basic decision mechanisms related to code mobility during the tree construction and destruction phases, namely: cloning, migration, merging and termination. We show some preliminary simulation results that confirm the viability of the approach and settle directions for further research. [less ▲]

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See detailLe syndrome du marteau
Denoel, C.; Collignon, L.; Dardenne, C. B. et al

in Revue Médicale de Liège (2001), 56(12), 830-4

The hypothenar hammer syndrome is an uncommon but underestimated lesion of the cubital artery caused by repetitive trauma at the level of the hamate bone. It characteristically occurs in patients with a ... [more ▼]

The hypothenar hammer syndrome is an uncommon but underestimated lesion of the cubital artery caused by repetitive trauma at the level of the hamate bone. It characteristically occurs in patients with a history of manual work as metal workers, carpenters and motor mechanics. We present a case of a patient who developed this syndrome following intensive use of a dig. Clinical finding, diagnosis and treatment are discussed. [less ▲]

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See detailTHE SUNFLOWER RIVER BLUES & GOSPEL FESTIVAL
Sacré, Robert ULg

in Soul Bag (2001), (165), 38-39

C.R. du Sunflower River Blues & Gospel Festival , Clarksdale, MS , 9-11 août 2001 Photo: Lonnie SHIELDS

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See detailA frequency domain versus a time domain identification technique for nonlinear parameters applied to wire rope isolators
Kerschen, Gaëtan ULg; Lenaerts, Vincent; Marchesiello, Stefano et al

in Journal of Dynamic Systems Measurement and Control-Transactions of the Asme (2001), 123(4), 645-650

The present paper aims to compare two techniques for identification of nonlinear dynamical systems. The Conditioned Reverse Path method, which is a frequency domain technique, is considered together with ... [more ▼]

The present paper aims to compare two techniques for identification of nonlinear dynamical systems. The Conditioned Reverse Path method, which is a frequency domain technique, is considered together with the Restoring Force Surface method, a time domain technique. Both methods are applied for experimental identification of wire rope isolators and the results are compared. Finally, drawbacks and advantages of each technique are underlined. [less ▲]

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See detailCloning and expression of the TALE superclass homeobox Meis2 gene during zebrafish embryonic development
Biemar, Frédéric; Devos, Nathalie; Martial, Joseph ULg et al

in Mechanisms of Development (2001), 109(2), 427-431

Meis and Prep/Pknox (MEINOX family) proteins, together with Pbx (PBC family) proteins, belong to the TALE superfamily characterized by an atypical homeodomain containing three additional amino acids ... [more ▼]

Meis and Prep/Pknox (MEINOX family) proteins, together with Pbx (PBC family) proteins, belong to the TALE superfamily characterized by an atypical homeodomain containing three additional amino acids between helix 1 and helix 2. Members of the MEINOX and PBC families have been isolated in Caenorhabditis elegans, Drosophila, Xenopus, chick, mouse and human. and play crucial roles in many aspects of embryogenesis. Here, we report the isolation of meis2 in zebrafish. Expression of meis2 is first detected at the beginning of gastrulation. Later during embryogenesis. meis2 transcripts are found in distinct domains of the central nervous system with the strongest expression in the hindbrain, Expression was also detected in the isthmus. along the spinal cord and in the lateral mesoderm, As development proceeds, meis2 is also expressed in the developing retina, pharyngeal arches, and in the vicinity of the gut tube. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailApplications en oncologie thoracique de la TEP--18FDG
Bury, Thierry ULg; Daenen, Frédéric ULg; Duysinx, Bernard ULg et al

in Revue des Maladies Respiratoires (2001), 18(6, Pt 1), 623-30

PositIon emission tomography using 18-fluorodeoxyglucose (FDG-PET) is an imaging technique based on metabolic criteria rather than morphological criteria. We discuss the contribution of this technique in ... [more ▼]

PositIon emission tomography using 18-fluorodeoxyglucose (FDG-PET) is an imaging technique based on metabolic criteria rather than morphological criteria. We discuss the contribution of this technique in the field of pulmonary oncology and we summarize our work which has demonstrated the performance capacity of PET: to discriminate the malignant nature of a solitary pulmonary nodule; to improve sensitivity over CT for mediastinal assessment in non-small cell lung cancer; to seRach for distant metastasis in patients with non-small cell lung cancer; to complement CT imaging to better dissociate tumor residue or recurrence from post-therapeutic sequelae in non-small cell lung cancer. Finally, we present different expected progress for the future. [less ▲]

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See detailPhosphorylation processes mediate rapid changes of brain aromatase activity
Balthazart, Jacques ULg; Baillien, M.; Ball, G. F.

in Journal of Steroid Biochemistry & Molecular Biology (2001), 79(1-5), 261-277

The enzyme aromatase (also called estrogen synthase) that catalyzes the transformation of testosterone (T) into estradiol plays a key limiting role in the action of T on many aspects of reproduction. The ... [more ▼]

The enzyme aromatase (also called estrogen synthase) that catalyzes the transformation of testosterone (T) into estradiol plays a key limiting role in the action of T on many aspects of reproduction. The distribution and regulation of aromatase in the quail brain has been studied by radioenzyme assays on microdissected brain areas, immunocytochemistry, RT-PCR and in situ hybridization. High levels of aromatase activity (AA) characterize the sexually dimorphic, steroid-sensitive medial preoptic nucleus (PONI), a critical site of T action and aromatization for the activation of male sexual behavior. The boundaries of the POM are clearly outlined by a dense population of aromatase-containing cells as visualized by both immunocytochemistry and in situ hybridization histochemistry. Aromatase synthesis in the POM is controlled by T and its metabolite estradiol, but estradiol receptors alpha (ERalpha) are not normally co-localized with aromatase in this brain area. Estradiol receptor beta (ERbeta) has been recently cloned in quail and localized in POM but we do not yet know whether ERbeta occurs in aromatase cells. It is therefore not known whether estrogens regulate aromatase synthesis directly or by affecting different inputs to aromatase cells as is the case with the gonadotropin releasing hormone neurons. The presence of aromatase in presynaptic boutons suggests that locally formed estrogens may exert part of their effects by non-genomic mechanisms at the membrane level. Rapid effects of estrogens in the brain that presumably take place at the neuronal membrane level have been described in other species. If fast transduction mechanisms for estrogen are available at the membrane level, this will not necessarily result in rapid changes in brain function if the availability of the ligand does not also change rapidly. We demonstrate here that AA in hypothalamic homogenates is rapidly down-regulated by exposure to conditions that enhance protein phosphorylation (addition of Ca2+, Mg2+, ATP). This inhibition is blocked by kinase inhibitors which supports the notion that phosphorylation processes are involved. A rapid (within minutes) and reversible regulation of AA is also observed in hypothalamic explants incubated in vitro and exposed to high Ca2+ levels (K+-induced depolarization, treatment by thapsigargin, by kainate, AMPA or NMDA). The local production and availability of estrogens in the brain can therefore be rapidly changed by Ca2+ based on variation in neurotransmitter activity. Locally-produced estrogens are as a consequence available for non-genomic regulation of neuronal physiology in a manner more akin to the action of a neuropeptide/neurotransmitter than previously thought. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailSystemic inflammatory response to cardiac surgery: does female sex really protect?
SEGHAYE, Marie-Christine ULg; Qing, M.; von Bernuth, G.

in Critical Care (2001), 5(6), 280-2

Sex hormones have important interactions with the immune system and modulate the inflammatory response. In this regard, oestrogen inhibits the transcription of proinflammatory cytokines and confers tissue ... [more ▼]

Sex hormones have important interactions with the immune system and modulate the inflammatory response. In this regard, oestrogen inhibits the transcription of proinflammatory cytokines and confers tissue protection in experimental models. On the basis of this evidence, Trotter et al. in this issue of Critical Care addressed the question of whether, in children, female sex would protect against the deleterious effects of cardiac operations with cardiopulmonary bypass by providing a favourable anti-inflammatory cytokine balance. The observations made in that study suggest sex-related immunomodulation and organ protection during cardiac surgery in the paediatric population. Prospective trials conducted in large series, including sex hormone determination in neonates, infants and children with congenital cardiac defects, are necessary to test this hypothesis. The verification of sex-related intraoperative organ protection would provide new opportunities for preventing the uncontrolled systemic inflammatory response that may occur during cardiac surgery. [less ▲]

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See detailLa demence en Belgique: taux de prevalence chez les sujets ages consultant en medecine generale
Kurz, X.; Scuvee-Moreau, J.; Salmon, Eric ULg et al

in Revue Médicale de Liège (2001), 56(12), 835-9

Early detection of dementia is an important element for the efficacy of therapies currently proposed to slow down disease progression. This detection mainly relies on general practitioners. In order to ... [more ▼]

Early detection of dementia is an important element for the efficacy of therapies currently proposed to slow down disease progression. This detection mainly relies on general practitioners. In order to estimate the impact of dementia on health services, we have estimated from the data of the NAtional Dementia Economic Study (NADES) the prevalence rate of dementia in patients aged > or = 65 years living at home and consulting in general practice. The study population was based on the sampling of consecutive patients consulting a general practitioner, irrespective of the reason and location of the consultation. The diagnosis of dementia was based on the CAMDEX performed at home in patients presenting > or = 3 warning signs of dementia. The prevalence rate of dementia among 2.234 registered patients living at home was 14.3% (CI95: 12.6-16.0). In age groups 65-74, 75-84 and > or = 85 years, it was 7.0%, 17.5% and 18.5%, respectively, in men, and 6.1%, 15.8% and 25.2%, respectively, in women. The percentage of demented with mild, mild to moderate, moderate and severe dementia was 35.0%, 38.8%, 13.1% and 13.1%, respectively. After adjusting for the age and sex distribution of the Belgian population, the prevalence rate in patients aged > or = 65 years was estimated at 11.3%. A diagnosis of dementia had already been made by a specialist in 41.5% of patients with dementia, with figures of 19.3%, 34.3%, 41.9% and 60.9% according to the severity of disease (mild, mild to moderate, moderate, severe). The onset of first symptoms had preceded the diagnosis by an average of 1 year. Our results show a high prevalence rate of dementia in the elderly living at home consulting in general practice, and less than half of the patients had previously been diagnosed. It is possible that a systematic detection will not be performed as long as specific treatments are not made widely available. [less ▲]

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See detailRecommandations pour la redaction de notices d'information pour les patients
Delvenne, Catherine ULg; Bonnet, Pierre ULg; Pasleau, Françoise ULg

in Revue Médicale de Liège (2001), 56(12), 840-5

With Evidence-Based Medicine, shared decision making is attracting considerable interest as a means by which patient preferences can be incorporated into clinical decisions. Patients cannot express ... [more ▼]

With Evidence-Based Medicine, shared decision making is attracting considerable interest as a means by which patient preferences can be incorporated into clinical decisions. Patients cannot express informed preferences unless they are given sufficient and appropriate information, including a detailed explanation concerning their condition, the different therapeutic options and the likely outcomes with and without treatment. A patient education leaflet is a potentially powerful tool for communicating information to patients, who will be able to participate in the process of decision making. The present article is a review of available guides for the writing of patient information materials. It also includes criteria for evaluating their quality. [less ▲]

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See detailLe controle du reseau vasculaire cutane
Damas, Jacques ULg; Garbacki, Nancy ULg; Liégeois, Jean-François ULg et al

in Revue Médicale de Liège (2001), 56(12), 846-9

In man, three kinds of sympathetic neurons reach the skin. Some cholinergic neurons stimulate the sweat glands, they are excited by temperature-regulating centers. Adrenergic neurons release noradrenaline ... [more ▼]

In man, three kinds of sympathetic neurons reach the skin. Some cholinergic neurons stimulate the sweat glands, they are excited by temperature-regulating centers. Adrenergic neurons release noradrenaline and ATP to reduce cutaneous blood flow while cholinergic neurons release acetylcholine and a co-transmitter to dilate skin blood vessels. The excitation of both latter types of nerve cells depends on influences from temperature-regulating centers, baroreceptors and exercise. Moreover, in cutaneous blood vessels, a synthesis of NO is enhanced by an increase of body temperature and overall by direct heating of the skin. Burns are associated with axon reflexes and release of inflammatory mediators. The involvement of these various influences is described. [less ▲]

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See detailPsychological distress of surgical patients after orthotopic heart transplantation
Triffaux, Jean-Marc ULg; Wauthy, Jacques ULg; Albert, Adelin ULg et al

in Transplant International (2001), 14(6), 391-395

Orthotopic heart transplantation (OHT) is a major surgical intervention inducing distress and anxiety. Psychological problems after OHT have been described in many studies. Little is known, however, about ... [more ▼]

Orthotopic heart transplantation (OHT) is a major surgical intervention inducing distress and anxiety. Psychological problems after OHT have been described in many studies. Little is known, however, about the relationship between the psychological state of the patient and time after surgery. The present study involved 41 consecutive OHT patients that underwent transplantation from January 1991 to December 1992, with a retrospective review of pretransplant psychiatric evaluations to define a Diagnostic and Statistical Manual of Mental Disorders, 3rd edn., revised (DSM III-R) Axis I diagnosis. Patients completed the Beck Depression Inventory (BDI-13), Spielberger's State Trait-Anxiety Inventory (STAI-Y), and the General Health Questionnaire (GHQ-28) between 1 and 41 months after transplantation. For comparison, 29 presumably healthy volunteers were given the same questionnaires. The study confirms the occurrence of abnormal psychological scores in the OHT group as compared to the reference population. Psychological scores, however, do not appear to be related to the time they were recorded after surgery. [less ▲]

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See detailAmplitude equations for Rayleigh-Benard convective rolls far from threshold
Dauby, Pierre ULg; Desaive, Thomas ULg; Bragard, J. et al

in Physical Review E (2001), 64(6), 66301

An extension of the amplitude method is proposed. An iterative algorithm is developed to build an amplitude equation model that is shown to provide precise quantitative results even far from the linear ... [more ▼]

An extension of the amplitude method is proposed. An iterative algorithm is developed to build an amplitude equation model that is shown to provide precise quantitative results even far from the linear instability threshold. The method is applied to the study of stationary Rayleigh-Benard thermoconvective rolls in the nonlinear regime. In particular, the generation of second and third spatial harmonics is analyzed. Comparison with experimental results and direct numerical calculations is also made and a very good agreement is found. [less ▲]

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See detailInfluence of Age, Sex and Body Condition on Zinc, Copper, Cadmium and Metallothioneins in Common Guillemots (Uria aalge) Stranded at the Belgian Coast.
Debacker, Virginie ULg; Schiettecatte, Laure-Sophie; Jauniaux, Thierry ULg et al

in Marine Environmental Research (2001), 52(5), 427-444

The common guillemots, Uria aalge, found stranded at the Belgian coast, display high levels of Cu in both liver and kidneys. The condition index of the animals, defined as the ratio of liver to kidneys ... [more ▼]

The common guillemots, Uria aalge, found stranded at the Belgian coast, display high levels of Cu in both liver and kidneys. The condition index of the animals, defined as the ratio of liver to kidneys mass (Wenzel & Adelung, 1996), influences both the metal concentration and its binding to metallothioneins (MT): the lower the condition index, the more emaciated the animals, and the higher the total Cu concentration and the concentration of Cu bound to MT. In less robust individuals, our results suggest that Cu could displaces Zn from MT rendering the Zn ions available to induce a new MT synthesis. Sex related effects also emerged as significantly higher hepatic MT as well as Cu- and Zn-MT concentrations were found in emaciated male guillemots compared to females. In both organs, Cd concentrations remained low and typically demonstrated an age-dependent renal accumulation, with no noticeable effect of the condition index. As a whole, these results suggest that, for guillemots found stranded at the Belgian coast, Cu binding to hepatic and renal MT could function as a protective mechanism, rendering the metal ions unavailable to exert any cytotoxic activity. [less ▲]

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See detailCoupled capillary and gravity-driven instability in a liquid film overlying a porous layer
Desaive, Thomas ULg; Lebon, Georgy ULg; Hennenberg, M.

in Physical Review E (2001), 64(6, Pt 2), 66304

In this work, we study the problem of onset of thermal convection in a fluid layer overlying a porous layer, the whole system being heated from below. We use Brinkman's model to describe the porous medium ... [more ▼]

In this work, we study the problem of onset of thermal convection in a fluid layer overlying a porous layer, the whole system being heated from below. We use Brinkman's model to describe the porous medium and determine the corresponding linear stability equations. The eigenvalue problem is solved by means of a modified Galerkin method. The behavior of the critical wave number and temperature gradient is discussed in terms of the various parameters of the system. We also emphasize the influence of the boundary conditions at the upper surface of the fluid layer; in particular, we examine the role of a free surface whose surface tension is temperature dependent (Marangoni effect). Comparison with earlier works is also made. [less ▲]

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See detailBehaviour of Crohn's Disease According to the Vienna Classification: Changing Pattern over the Course of the Disease
Louis, Edouard ULg; Mathieu, Anne ULg; Oger, A. F. et al

in Gut (2001), 49(6), 777-82

BACKGROUND: Crohn's disease is a heterogeneous disorder with both a genetic and environmental aetiology. Clinical classifications of the disease, such as the newly proposed Vienna classification, may help ... [more ▼]

BACKGROUND: Crohn's disease is a heterogeneous disorder with both a genetic and environmental aetiology. Clinical classifications of the disease, such as the newly proposed Vienna classification, may help to define subgroups of patients suitable for studying the influence of specific genetic or environmental factors. AIM: To assess the stability over the course of the disease of its location and behaviour, as determined according to the Vienna classification. PATIENTS AND METHODS: The notes of 297 Crohn's disease patients regularly followed up at our institution were carefully reviewed retrospectively. The behaviour and location of the disease according to the Vienna classification were determined at diagnosis and after 1, 3, 5, 10, 15, 20, and 25 years of follow up. The proportions of the different behaviours and locations of the disease were calculated at these time points. A statistical analysis of the evolution of these characteristics over 10 years was performed on a subgroup of 125 patients with at least 10 years of follow up. The influence of age at diagnosis on location and behaviour of the disease was assessed as well as the influence of location on the behaviour of the disease. RESULTS: The location of the disease remained relatively stable over the course of the disease. Although the proportion of patients who had a change in disease location became statistically significant after five years (p=0.01), over 10 years only 15.9% of patients had a change in location (p<0.001). We observed a more rapid and prominent change in disease behaviour, which was already statistically significant after one year (p=0.04). Over 10 years, 45.9% of patients had a change in disease behaviour (p<0.0001). The most prominent change was from non-stricturing non-penetrating disease to either stricturing (27.1%; p<0.0001) or penetrating (29.4%; p<0.0001) disease. Age at diagnosis had no influence on either location or behaviour of disease. Ileal Crohn's disease was more often stricturing, and colonic or ileocolonic Crohn's disease was more often penetrating: this was already the case at diagnosis and became more prominent after 10 years (p<0.05). CONCLUSIONS: Location of Crohn's disease, as defined by the Vienna classification, is a relatively stable phenotype which seems suitable for phenotype-genotype analyses. Behaviour of Crohn's disease according to the Vienna classification varies dramatically over the course of the disease and cannot be used in phenotype-genotype analyses. The potential influence of genes on the behaviour of Crohn's disease should be studied in subgroups of patients defined by their disease behaviour after a fixed duration of disease. [less ▲]

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See detailImportance of soft solution processing for advanced BaZrO3 materials
Robertz, B.; Boschini, Frédéric ULg; Cloots, Rudi ULg et al

in International Journal of Inorganic Materials (2001), 3(8), 1185-1187

Barium zirconate is an interesting material for refractory applications as well as a good substrate for the manufacturing of high temperature superconductors. However, its solid state synthesis requires ... [more ▼]

Barium zirconate is an interesting material for refractory applications as well as a good substrate for the manufacturing of high temperature superconductors. However, its solid state synthesis requires high temperature and provides inhomogeneous powder with a broad particle size distribution. In order to avoid these disadvantages, soft solution routes are of growing importance in the ceramic powder synthesis. Precipitation. decomposition of precursors, combustion techniques offer alternative ways to the solid state method. Advantages of these are a lower calcination temperature, production of homogeneous and fine monodisperse powders. The obtained powders have been characterised by XRD, IR, SEM and DTA/TG analysis. The influence of the synthesis conditions on the properties of BaZrO3 has been studied. (C) 2001 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailAffections bénignes et radiothérapie : une enquête de la pratique en Belgique. Peer review de radiothérapie de BelgiqueBenign disease in radiation therapy: a survey in Belgium.
Vanderick, JEAN ULg; Baudouin; Deneufbourg, Jean-Marie ULg et al

in Cancer Radiotherapie (2001), 5(6), 766-9

n 1996 and 2000, a survey of radiation practice in Belgium was performed by sending a questionnaire to the different centers asking their opinion and number of patients treated. There was a great ... [more ▼]

n 1996 and 2000, a survey of radiation practice in Belgium was performed by sending a questionnaire to the different centers asking their opinion and number of patients treated. There was a great similarity between the two surveys both for indications and total number of patients irradiated. For the most common indications (prevention of cheloids, heterotopic bone formation, hyperthyroidy ophtalmopathy), there was a trend to use similar radiation technique following recent publications. In contrast, if the number of cases of macular degeneration is declining, the prevention of vessels restenosis is becoming more and more an indication. [less ▲]

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See detailGuidelines for brain radionuclide imaging - Perfusion Single Photon Computed Tomography (SPECT) using Tc-99m radiopharmaceuticals and brain metabolism Positron Emission Tomography (PET) using F-18 fluorodeoxyglucose
Vander Borght, T.; Laloux, P.; Maes, A. et al

in Acta Neurologica Belgica (2001), 101(4), 196-209

The purpose of these guidelines is to assist nuclear medicine practitioners in recommending, performing, interpreting, and reporting the results of brain perfusion SPECT studies using Tc-99m ... [more ▼]

The purpose of these guidelines is to assist nuclear medicine practitioners in recommending, performing, interpreting, and reporting the results of brain perfusion SPECT studies using Tc-99m radiopharmaceuticals and brain metabolism PET studies using F-18 fluorodeoxyglucose (FDG). These guidelines have been adapted and extended from those produced by the Society, of Nuclear Medicine (Juni et al., 1998) and the European Association of Nuclear Medicine by, a Belgian group of experts in the field trained in neurology and/or nuclear medicine. Some indications are not universally approved (e.g. brain death), but largely, supported by the literature. They, have been included in these guidelines in order to provide recommendations and a standardised protocol [less ▲]

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See detailIdentification of viable myocardium early after acute myocardial infarction using closed-loop arbutamine echocardiography: comparison with positron emission tomography
PIERARD, Luc ULg; MELON, Pierre ULg; LANCELLOTTI, Patrizio ULg et al

in Acta Cardiologica (2001), 56(6), 387-394

Objective -This study sought to evaluate the safety and efficacy of arbutamine echocardiography in identifying contractile reserve and predicting functional improvement early after acute myocardial ... [more ▼]

Objective -This study sought to evaluate the safety and efficacy of arbutamine echocardiography in identifying contractile reserve and predicting functional improvement early after acute myocardial infarction (AMI). Methods and results - Seventeen patients with first AMI underwent arbutamine echocardiography 48 to 96 hours after AMI. Arbutamine was infused by a closed-loop delivery device. The heart rate slope was 4 beats/min and the heart rate target was 20 beats/min above baseline heart rate. A follow-up echocardiogram was obtained one month later. N- 13 ammonia and F- 18 FDG positron emission tomographic (PET) imaging were performed 6 2 days after AMI, before coronary angiography. Mean duration of arbutamine infusion was 6 2 min. There was no complication and there were no major side effects. Myocardial viability was identified with PET in 15 of the 17 patients. Contractile reserve was observed in 10 patients during arbutamine infusion. Functional recovery was identified in 12 patients. Sensitivity, specificity and accuracy of PET and arbutamine echocardiography for predicting functional recovery were 100%, 40%, 76% and 67%, 80%, 84%, respectively. Conclusions - Low-dose arbutamine stress testing is safe early after AMI. Contractile reserve can be rapidly identified by echo cardiography and is specific, but moderately sensitive for predicting reversible dysfunction. [less ▲]

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See detailL'accident sur le chemin du travail. Les interruptions et les détours
Michiels, Olivier ULg

in Lexius Actua (2001), 10

L'article s'attache à la notion d'accident sur le chemin du travail et sur les détours et les interruptions lors de la réalisation de ce trajet.

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See detailFonctionnement et performances des couloirs oscillants à glissement
Debongnie, Jean-François ULg; Masset, Luc ULg

in European Journal of Mechanical and Environmental Engineering (2001), 46(4), 243-254

This paper is devoted to the study of the efficiency of an oscillating trough for any value of the frequency. It is found that pure slipping or mixed cycles may occur, the latter comprising sticking ... [more ▼]

This paper is devoted to the study of the efficiency of an oscillating trough for any value of the frequency. It is found that pure slipping or mixed cycles may occur, the latter comprising sticking periods. The results of the present analysis concern the cyclic displacement, the mean velocity and the dissipated power. [less ▲]

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See detailModelling of speleothems failure in the Hotton cave (Belgium). Is the failure earthquake induced?
Cadorin, Jean-François; Jongmans, Denis; Camelbeeck, Thierry et al

in Netherlands Journal of Geosciences - Geologie en Mijnbouw (2001), 80(3-4), 315-321

To provide quantitative information on the ground acceleration necessary to break speleothems, laboratory measurements on samples of stalagmite have been performed to study their failure in bending. Due ... [more ▼]

To provide quantitative information on the ground acceleration necessary to break speleothems, laboratory measurements on samples of stalagmite have been performed to study their failure in bending. Due to their high natural frequencies, speleothems can be considered as rigid bodies to seismic strong ground motion. Using this simple hypothesis and the determined mechanical properties (a minimum value of 0.4 MPa for the tensile failure stress has been considered), modelling indicates that horizontal acceleration ranging from 0.3 m/s(2) to 100 m/s(2) (0.03 to 10g) are necessary to break 35 broken speleothems of the Hotton cave for which the geometrical parameters have been determined. Thus, at the present time, a strong discrepancy exists between the peak accelerations observed during earthquakes and most of the calculated values necessary to break speleothems. One of the future research efforts will be to understand the reasons of the defined behaviour. It appears fundamental to perform measurements on in situ speleothems. [less ▲]

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See detailGIS-based hydrogeological databases and groundwater modelling
Gogu, Radu Constantin; Carabin, Guy; Hallet, Vincent et al

in Hydrogeology Journal (2001), 9(6), 555-569

Reliability and validity of groundwater analysis strongly depend on the availability of large volumes of high-quality data. Putting all data into a coherent and logical structure supported by a computing ... [more ▼]

Reliability and validity of groundwater analysis strongly depend on the availability of large volumes of high-quality data. Putting all data into a coherent and logical structure supported by a computing environment helps ensure validity and availability and provides a powerful tool for hydrogeological studies. A hydrogeological geographic information system (GIS) database that offers facilities for groundwater-vulnerability analysis and hydrogeological modelling has been designed in Belgium for the Walloon region. Data from five river basins, chosen for their contrasting hydrogeological characteristics, have been included in the database, and a set of applications that have been developed now allow further advances. Interest is growing in the potential for integrating GIS technology and groundwater simulation models. A "loose-coupling" tool was created between the spatial-database scheme and the groundwater numerical model interface GMS (Groundwater Modelling System). Following time and spatial queries, the hydrogeological data stored in the database can be easily used within different groundwater numerical models. [less ▲]

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See detail180 degrees Pinhole SPET with a tilted detector and OS-EM reconstruction: phantom studies and potential clinical applications
Seret, Alain ULg; Defrise, Michel ULg; Blocklet, Didier

in European Journal of Nuclear Medicine (2001), 28(12), 1836-1841

This study investigated the feasibility of ordered subsets expectation maximisation (OS-EM) reconstruction of pinhole single-photon emission tomography (SPET) acquired with a tilted detector head and a ... [more ▼]

This study investigated the feasibility of ordered subsets expectation maximisation (OS-EM) reconstruction of pinhole single-photon emission tomography (SPET) acquired with a tilted detector head and a 180 degrees orbit. Phantom and patient data were recorded using a standard single-head camera. Reconstructions were performed using a dedicated OS-EM algorithm. Reconstructed images of line, uniformity and Picker's thyroid phantoms showed that the geometry, physical size and uniformity of the radioactive objects were preserved. For the range of radius corresponding to the patient studies, the measured full-widths at half-maximum lay between 4.90+/-0.25 mm and 6.05+/-0.25 mm. Finally, the gain in resolution associated with the use of the pinhole collimator instead of a parallel-hole collimator was highlighted in a parathyroid exploration and in a shoulder bone study. [less ▲]

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See detailUltrasonographic abnormalities of the palmar aspect of the fetlock and pastern
Busoni, Valeria ULg

in Ippologia (2001), 12(4), 5-11

Ultrasonography is necessary to diagnose and differentiate soft tissues injuries of the palmar aspect of fetlock and pastern and completes the examination in cases with radiographic abnormalities on the ... [more ▼]

Ultrasonography is necessary to diagnose and differentiate soft tissues injuries of the palmar aspect of fetlock and pastern and completes the examination in cases with radiographic abnormalities on the proximal sesamoid bones. This paper reviews some of the injuries which can involve the anatomical structures of the palmar fetlock and pastern regions. [less ▲]

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See detailObituary : Roebuck "Pops" STAPLES
Sacré, Robert ULg

in Soul Bag (2001), (162), 42

Roebuck "Pops" Staples 1915-2000

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See detailCommunication interventriculaire et infarctus récent du myocarde
Delanaye, Pierre ULg; Lancellotti, Patrizio ULg; Moonen, Martial et al

in Revue Médicale de Liège (2001), 56(12), 823-829

Rupture of the interventricular septum is a classical complication of acute myocardial infarction. The diagnosis should be evoked when the patient's hemodynamic condition deteriorates in the presence of a ... [more ▼]

Rupture of the interventricular septum is a classical complication of acute myocardial infarction. The diagnosis should be evoked when the patient's hemodynamic condition deteriorates in the presence of a new systolic murmur. A transthoracic or, preferably, transesophageal echocardiography confirms the diagnosis. Early surgical correction constitutes the best treatment. Despite recent progresses, mortality remains high but long term results are encouraging. The risk factors conditioning prognosis, the surgical options and the question of simultaneous coronary bypass will be discussed after a thorough review of the literature. [less ▲]

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See detailPyelonephrite xanthogranulomateuse pseudotumorale: diagnostic par la biopsie percutanee et succes du traitement conservateur
Reul, Olivier ULg; Waltregny, David ULg; Boverie, Jacques ULg et al

in Progrès en Urologie (2001), 11(6), 1274-6

Focal xanthogranulomatous pyelonephritis is an unusual form of chronic renal infection that is difficult to diagnose prior to surgery. We report on a 19-year-old woman who presented with a renal mass that ... [more ▼]

Focal xanthogranulomatous pyelonephritis is an unusual form of chronic renal infection that is difficult to diagnose prior to surgery. We report on a 19-year-old woman who presented with a renal mass that mimicked malignancy. The diagnosis of focal xanthogranulomatous pyelonephritis was first suspected by radiological findings and further confirmed by histopathologic examination of percutaneous biopsy specimens of the lesion. Successful treatment of the patient was achieved with antibiotic therapy alone. Maximal efforts, including percutaneous renal biopsy, should be made to establish the diagnosis of focal xanthogranulomatous pyelonephritis before a therapeutic decision is reached. We recommend the use of antibiotics as a first-line treatment for patients with focal xanthogranulomatous pyelonephritis. [less ▲]

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See detailInduced sputum - Comparison between isotonic and hypertonic saline solution inhalation in patients with asthma
Cataldo, Didier ULg; Foidart, Jean-Michel ULg; Lau, L. et al

in CHEST (2001), 120(6), 1815-1821

Background: Sputum induction by hypertonic saline solution inhalation is widely used to study airways secretions in patients with asthma. However, hypertonic saline solution is a potent indirect ... [more ▼]

Background: Sputum induction by hypertonic saline solution inhalation is widely used to study airways secretions in patients with asthma. However, hypertonic saline solution is a potent indirect bronchoconstrictor. Study objectives: We studied the validity of isotonic saline solution (0.9%) inhalation as a means to induce sputum by comparing it to hypertonic saline solution (4.5%) inhalation. Patients: Sixteen patients with moderate-to-severe asthma reporting a clinical history of mucus hypersecretion. Methods: Subjects underwent sputum induction twice at 1-week intervals. Saline solution (hypertonic or isotonic) was inhaled For three periods of 5 min. The parameters assessed in sputum samples were cell counts, sodium, eosinophil cationic protein (ECP), and albumin concentrations, osmolality, and pro-matrix metalloproteinase (MMP)-9 activity by zymography. Results: The maximal fall in peak expiratory flow during sputum induction was greater after inhalation of hypertonic saline solution than after inhalation of isotonic saline solution (p < 0.01). Each subject produced analyzable sputum on both visits. There were no statistically significant differences in total and differential sputum cell counts, and the reproducibility coefficients were high for eosinophils and neutrophils when comparing the two methods. Likewise, sputum levels of ECP and albumin as well as sputum pro-MMP-9 activity were not different between the two methods, and were highly reproducible as shown by high intraclass coefficients (Ri) of correlation (0.72, 0.74, and 0.77 for ECP, albumin, and pro-MMP-9, respectively). Sputum sodium concentrations and osmolality were higher after inhalation of hypertonic saline solution (p < 0.05). Conclusion: In patients with moderate-to-severe asthma reporting a clinical history of mucus hypersecretion, inducing sputum by isotonic or hypertonic saline solution inhalation leads to comparable results in eosinophil and neutrophil cell counts and fluid phase mediators/proteins. [less ▲]

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See detailLa guerre et la medecine d'une culture de paix. 2. Synopsis des armes biologiques
Pierard, Gérald ULg

in Revue Médicale de Liège (2001), 56(12), 850-4

Biological warfare has a long history. Despite the 1972 international convention and several attempts at biological weapon eradication, some countries and non governmental groups still retain some of ... [more ▼]

Biological warfare has a long history. Despite the 1972 international convention and several attempts at biological weapon eradication, some countries and non governmental groups still retain some of these agents. According to their potential use, they belong to bioterrorism or to massive destruction weapons. Any biological warfare put the civilian medical and paramedical assets at the frontline and at high risk for being rapidly contaminated. The prompt recognition of a bioterrorist attack and the swift identification of the agent can lead to implementation of vaccines, chemoprophylaxis, appropriate treatment and sanitary measures. [less ▲]

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See detailSpa, ensemble architectural du parc de Sept-Heures [...]
Heins, Pascal ULg

in Histoire et Archéologie spadoises (2001), 108(32), 176-184

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See detailMetal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach
De Seny, Dominique ULg; Heinz, U.; Wommer, S. et al

in Journal of Biological Chemistry (2001), 276(48), 45065-78

One high affinity (nm) and one low affinity (microM) macroscopic dissociation constant for the binding of metal ions were found for the wild-type metallo-beta-lactamase from Bacillus cereus as well as six ... [more ▼]

One high affinity (nm) and one low affinity (microM) macroscopic dissociation constant for the binding of metal ions were found for the wild-type metallo-beta-lactamase from Bacillus cereus as well as six single-site mutants in which all ligands in the two metal binding sites were altered. Surprisingly, the mutations did not cause a specific alteration of the affinity of metal ions for the sole modified binding site as determined by extended x-ray absorption fine structure (EXAFS) and perturbed angular correlation of gamma-rays spectroscopy, respectively. Also UV-visible absorption spectra for the mono-cobalt enzymes clearly contain contributions from both metal sites. The observations of the very similar microscopic dissociation constants of both binding sites in contrast to the significantly differing macroscopic dissociation constants inevitably led to the conclusion that binding to the two metal sites exhibits negative cooperativity. The slow association rates for forming the binuclear enzyme determined by stopped-flow fluorescence measurements suggested that fast metal exchange between the two sites for the mononuclear enzyme hinders the binding of a second metal ion. EXAFS spectroscopy of the mono- and di-zinc wild type enzymes and two di-zinc mutants provide a definition of the metal ion environments, which is compared with the available x-ray crystallographic data. [less ▲]

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See detailOrganisation and in Vitro Expression of Esp Genes of the Lee (Locus of Enterocyte Effacement) of Bovine Enteropathogenic and Enterohemorrhagic Escherichia Coli
Goffaux, Ffédéric; China, Bernard; Mainil, Jacques ULg

in Veterinary Microbiology (2001), 83(3), 275-86

Enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Escherichia coli infections are characterised by the formation of attaching and effacing (AE) lesions on intestinal epithelial cells. Secretion of ... [more ▼]

Enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Escherichia coli infections are characterised by the formation of attaching and effacing (AE) lesions on intestinal epithelial cells. Secretion of extracellular proteins (EspA, EspB, and EspD) via a type III secretion apparatus is necessary for the formation of the AE lesions by human EPEC. In this study, we show that bovine EPEC and EHEC are also able to secrete polypeptides homologous to the already described Esp proteins, most probably via a type III secretion system. Bovine EPEC and EHEC strains present two different secretion profiles of Esp proteins which correlate to the pathotypes of the esp genes as determined by PCR. We also demonstrate that genes encoding secreted proteins, present in the LEE of two bovine strains, are organised in the same way as in the human EPEC strain E2348/69. [less ▲]

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See detailNew Histochemical and Ultrastructural Observations on Normal Bovine Tonsils
Velinova, Maria; Thielen, Caroline ULg; Mélot, France ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2001), 149(20), 613-7

Samples of normal bovine palatine tonsils were examined by light and electron microscopy. Like human tonsils, they were composed of crypts, subepithelial areas, follicles, and T-dependent zones, but their ... [more ▼]

Samples of normal bovine palatine tonsils were examined by light and electron microscopy. Like human tonsils, they were composed of crypts, subepithelial areas, follicles, and T-dependent zones, but their well-developed capsule subdivided the lymphoid tissue by connective septa. B cells formed the major lymphoid component. The follicles and T-dependent zones had morphological and histochemical features typical of peripheral lymph organs. Follicular dendritic cells were isolated and shown to be similar to human follicular dendritic cells. [less ▲]

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See detailPhenotypic variation of a novel nonsense mutation in the P0 intracellular domain
Senderek, J.; Ramaekers, Vincent ULg; Zerres, K. et al

in Journal of the Neurological Sciences (2001), 192(1-2), 49-51

Mutations in the gene for the peripheral myelin protein zero (P0, MPZ) cause type 1B of Charcot-Marie-Tooth sensorimotor neuropathy (CMT1B). Here we report a German family with a novel heterozygous P0 ... [more ▼]

Mutations in the gene for the peripheral myelin protein zero (P0, MPZ) cause type 1B of Charcot-Marie-Tooth sensorimotor neuropathy (CMT1B). Here we report a German family with a novel heterozygous P0 nonsense mutation (G206X) that supposedly removes four-fifths of the amino acid residues constituting the P0 intracellular domain. The 12-year-old propositus had childhood-onset CMT1B associated with bilateral pes cavus, moderate lower limb weakness, and mildly reduced sensory qualities in the distal legs. The electrophysiology was consistent with a demyelinating neuropathy. He inherited the mutation from his mother who had no complaints but slight pes cavus deformity and slow nerve conduction velocities (NCV). Conclusively, truncating mutations within the P0 intracellular domain do not necessarily cause a severe phenotype such as Dejerine-Sottas syndrome (DSS) or congenital hypomyelinating neuropathy (CHN), but can result in mild or moderate CMT1B with intrafamilial clinical variability. Copyright © 2001 Elsevier Science B.V. [less ▲]

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See detailQuantitation of Functional Mitral Regurgitation During Bicycle Exercise in Patients with Heart Failure
Lebrun, F.; LANCELLOTTI, Patrizio ULg; PIERARD, Luc ULg

in Journal of the American College of Cardiology (2001), 38(6), 1685-92

OBJECTIVES: We sought to examine the feasibility and reliability of quantifying mitral regurgitation (MR) during exercise by Doppler echocardiography in patients with heart failure and to assess the ... [more ▼]

OBJECTIVES: We sought to examine the feasibility and reliability of quantifying mitral regurgitation (MR) during exercise by Doppler echocardiography in patients with heart failure and to assess the relationship between dynamic MR and systolic pulmonary artery pressure changes. BACKGROUND: The severity of MR can be quantified by using several echocardiographic methods. Quantitation of MR during dynamic exercise has not yet been performed. METHODS: Symptom-limited, semi-supine two-dimensional and Doppler echocardiograms during bicycle exercise were obtained in 27 consecutive patients with heart failure and functional MR. Regurgitant volume was measured at rest and during exercise by the proximal isovelocity surface area (PISA) method and by quantitative Doppler echocardiography. Exercise-induced changes in regurgitant volume were compared with changes in the regurgitant jet area to left atrial area ratio, vena contracta width and trans-tricuspid pressure gradient. RESULTS: The regurgitant volume measured by the PISA method increased from 21 +/- 12 ml (range 5 to 55) at rest to 39 +/- 23 ml (range 8 to 85) during exercise (p < 0.0001). The difference between two observers was low for both rest (2.0 +/- 2.7 ml) and exercise measurements (3.5 +/- 6.2 ml). The regurgitant volume measured by quantitative Doppler echocardiography increased from 29 +/- 13 to 49 +/- 24 ml (p = 0.0001). Excellent correlation between the two methods was obtained with exercise (r = 0.92). Exercise-induced changes in regurgitant volume, as measured by the PISA method, correlated well with regurgitant volume changes measured by quantitative Doppler echocardiography (r = 0.88), changes in vena contracta width (r = 0.82) and changes in trans-tricuspid pressure gradient (r = 0.73), but not with changes in regurgitant jet area to left atrial area ratio (r = 0.29). Seventeen patients stopped exercise because of fatigue and 10 because of dyspnea. These 10 patients exhibited greater increases in regurgitant volume (34 +/- 6 vs. 11 +/- 8 ml), corresponding to a significant elevation of the trans-tricuspid gradient (48 +/- 14 vs. 20 +/- 14 mm Hg). CONCLUSIONS: Quantitation of functional MR during exercise is feasible in patients with heart failure. There is a good correlation between regurgitant volume measured during exercise by the PISA method and that obtained by quantitative Doppler echocardiography, suggesting that the technique is reliable. An increase in mitral regurgitant volume during dynamic exercise correlates well with elevation of systolic pulmonary artery pressure. [less ▲]

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See detailThe European Large Area ISO Survey - VI. Discovery of a new hyperluminous infrared galaxy
Morel, Thierry ULg; Efstathiou, A.; Serjeant, S. et al

in Monthly Notices of the Royal Astronomical Society (2001), 327

We report the discovery of the first hyperluminous infrared galaxy (HyLIG) in the course of the European Large Area ISO Survey (ELAIS). This object has been detected by ISO at 6.7, 15 and 90μm, and is ... [more ▼]

We report the discovery of the first hyperluminous infrared galaxy (HyLIG) in the course of the European Large Area ISO Survey (ELAIS). This object has been detected by ISO at 6.7, 15 and 90μm, and is found to be a broad-line, radio-quiet quasar at a redshift [formmu4]z=1.099. From a detailed multicomponent model fit of the spectral energy distribution, we derive a total IR luminosity L[SUB]IR[/SUB] [formmu5](1-1000μm)~1.0à 10[SUP]13[/SUP]h65-2L[SUB]solar[/SUB] [formmu6](q[SUB]0[/SUB]=0.5), and discuss the possible existence of a starburst contributing to the far-IR output. Observations to date present no evidence for lens magnification. This galaxy is one of the very few HyLIGs with a X-ray detection. On the basis of its soft X-ray properties, we suggest that this broad-line object may be the face-on analogue of narrow-line, Seyfert-like HyLIGs. [less ▲]

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See detailSignificance of Dobutamine-Induced Changes in Qt Dispersion Early after Acute Myocardial Infarction
LANCELLOTTI, Patrizio ULg; Bilge, A. R.; Mipinda, J. B. et al

in American Journal of Cardiology (2001), 88(9), 939-43

This study sought to examine the effects of graded dobutamine infusion on QT dispersion early after acute myocardial infarction (AMI) and to investigate the relation of dobutamine-induced changes in QT ... [more ▼]

This study sought to examine the effects of graded dobutamine infusion on QT dispersion early after acute myocardial infarction (AMI) and to investigate the relation of dobutamine-induced changes in QT dispersion to wall motion responses. Seventy-eight patients with a first AMI underwent dobutamine-atropine stress echocardiography 5 +/- 2 days after admission. Contractile reserve was identified in 45 patients and ischemic myocardium in 40. Sixteen patients had persistent akinesia. The best cut-off value of QT dispersion on the baseline electrocardiogram for predicting myocardial viability was 65 ms (sensitivity and specificity of 68%). Dobutamine infusion increased QT dispersion only in patients with viable myocardium (61 +/- 18 to 83 +/- 19 ms, p = 0.003) and/or ischemia (72 +/- 16 to 112 +/- 25 ms, p < 0.0001). No change was observed in patients with persistent akinesia (84 +/- 10 to 87 +/- 15 ms, p = NS). QT dispersion increased by 22 +/- 12 ms with administration of low-dose dobutamine in patients who had viable myocardium and by 47 +/- 21 ms with administration of low- to high-dose dobutamine in patients with ischemic myocardium. An increase in QT dispersion of > or = 20 ms from at rest to low-dose dobutamine infusion was associated with myocardial viability with a sensitivity of 78% and a specificity of 79%, whereas an increase in QT dispersion of > or = 10 ms from low- to high-dose dobutamine infusion predicted ischemic myocardium with a sensitivity of 85% and a specificity of 82%. In conclusion, (1) low QT dispersion on the baseline electrocardiogram is determined by the presence of viable myocardium, (2) a dobutamine-induced increase in QT dispersion is associated with viable and jeopardized myocardium, and (3) unchanged QT dispersion during dobutamine stress is a simple marker of extensive necrosis. [less ▲]

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See detailDobutamine Stress Echocardiography Versus Quantitative Technetium-99m Sestamibi Spect for Detecting Residual Stenosis and Multivessel Disease after Myocardial Infarction
LANCELLOTTI, Patrizio ULg; Benoit, T.; Rigo, Pierre ULg et al

in Heart (2001), 86(5), 510-5

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting ... [more ▼]

OBJECTIVE: To compare the relative accuracy of dobutamine stress echocardiography (DSE) and quantitative technetium-99m sestamibi single photon emission computed tomography (mibi SPECT) for detecting infarct related artery stenosis and multivessel disease early after acute myocardial infarction. DESIGN: Prospective study. SETTING: University hospital. METHODS: 75 patients underwent simultaneous DSE and mibi SPECT at (mean (SD)) 5 (2) days after a first acute myocardial infarct. Quantitative coronary angiography was performed in all patients after imaging studies. RESULTS: Significant stenosis (> 50%) of the infarct related artery was detected in 69 patients. Residual ischaemia was identified by DSE in 55 patients and by quantitative mibi SPECT in 49. The sensitivity of DSE and mibi SPECT for detecting significant infarct related artery stenosis was 78% and 70%, respectively, with a specificity of 83% for both tests. The combination of DSE and mibi SPECT did not change the specificity (83%) but increased the sensitivity to 94%. Mibi SPECT was more sensitive than DSE for detecting mild stenosis (73% v 9%; p = 0.008). The sensitivity of DSE for detecting moderate or severe stenosis was greater than mibi SPECT (97% v 74%; p = 0.007). Wall motion abnormalities with DSE and transient perfusion defects with mibi SPECT outside the infarction zone were sensitive (80% v 67%; NS) and highly specific (95% v 93%; NS) for multivessel disease. CONCLUSIONS: DSE and mibi SPECT have equivalent accuracy for detecting residual infarct related artery stenosis of >/= 50% and multivessel disease early after acute myocardial infarction. DSE is more predictive of moderate or severe infarct related artery stenosis. Combined imaging only improves the detection of mild stenosis. [less ▲]

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See detailPresentation anatomo-clinique. Terato-carcinome testiculaire avec adenopathies thoraco-abdominales
Dassy, S.; Coibion-Jossa, V.; Demelenne, A. et al

in Revue Médicale de Liège (2001), 56(11), 777-84

This case report of a young man with a testicular germ cell-teratoma tumor illustrates the necessity of a multidisciplinary sequential approach to ensure chance of cure. The outcome of patients with ... [more ▼]

This case report of a young man with a testicular germ cell-teratoma tumor illustrates the necessity of a multidisciplinary sequential approach to ensure chance of cure. The outcome of patients with advanced germ cell tumor depends on the optimal clinical management. Residual masses are frequent, and their histology can be different than the initial one (i.e., only residual mature teratoma cells or necrosis-fibrosis). Therefore a second surgery on residual masses with curative intent, may be important to optimalize the treatment and follow up. [less ▲]

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See detailDiagnostisch beleid bij verhoogde transaminasenspiegels
Delwaide, Jean ULg; Delfosse, V.; Detry, Olivier ULg et al

in Patient Care (Nederlandse Editie) (2001), 28(11), 33-41

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See detailPlasma profile of pregnancy associated glycoprotein (PAG) in pregnant Alpine goats using two radioimmunoassay (RIA) systems
Batalha, E. S.; Sulon, Joseph ULg; Figueiredo, J. R. et al

in Small Ruminant Research (2001), 42(2), 111-118

This paper evaluates the profiles obtained for caprine pregnancy associated glycoprotein (cPAG) in pregnant multiparous and nulliparous goats using the heterologous-radioimmunoassay (htPAG-RIA) and the ... [more ▼]

This paper evaluates the profiles obtained for caprine pregnancy associated glycoprotein (cPAG) in pregnant multiparous and nulliparous goats using the heterologous-radioimmunoassay (htPAG-RIA) and the homologous-RIA (hmPAG-RIA) systems during the pregnancy and postpartum periods. The results show that the cPAG concentrations detected through the hmPAG-RIA procedure were lower than those found through the htPAG-RIA method. No statistical differences were observed due to the maternal reproductive status (nulliparous or multiparous goats) during pregnancy using either one of the methods. However, pregnant and cyclic goats were distinguished from each other by cPAG concentrations verified through the hmPAG-RIA procedure. The lower cPAG concentrations detected through this method suggest that this system is more specific than the htPAG-RIA procedure to measure cPAG during pregnancy and postpartum period in goats. The homologous system was also an efficient method to predict pregnancies of only 35 days in both nulliparous and multiparous goats. (C) 2001 Published by Elsevier Science B.V. [less ▲]

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See detailNormal ranges for the variability in heart rate in young infants while sleeping
Massin, M. M.; Withofs, Nadia ULg; Maeyns, K. et al

in Cardiology in the Young (2001), 11(6), 619-625

Objective: Measurements of the variability in heart rate are increasingly used as markers of cardiac autonomic activity. We sought to establish the development this variability in healthy young infants ... [more ▼]

Objective: Measurements of the variability in heart rate are increasingly used as markers of cardiac autonomic activity. We sought to establish the development this variability in healthy young infants while sleeping. Patients: We carried out polygraphic studies with electrocardiographic recording in 587 healthy infants aged from 5 to 26 weeks. Methods: We determined several variables over a period of 400 minutes sleeping: mean RR interval, 5 time-domain (SDNN, SDNNi, SDANNi, RMSSD, and pNN50) and 5 frequency-domain indexes (spectral power over 3 regions of interest, total power and low-to-high frequency ratio). Frequency-domain indexes were also assessed separately for the periods of quiet sleep and those of rapid eye movement sleep. Results: Our data showed a significant correlation between the indexes of heart rate variability and the mean RR interval, the breathing rate, and the corrected age of the infants. We also demonstrated the importance of the maturation of the sleeping patterns. Conclusion: These data in a large cohort of healthy infants confirm a progressive maturation of the autonomic nervous system during sleep, and may be used to examine the influence of physiological and pathophysiological factors on autonomic control during polygraphic studies. [less ▲]

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See detailRelationship between maternal concentrations of caprine pregnancy-associated glycoprotein in Alpine goats and the number of fetuses using a homologous radioimmunoassay
Batalha, E. S.; Sulon, Joseph ULg; Figueiredo, J. R. et al

in Small Ruminant Research (2001), 42(2), 105-109

The relationship between maternal caprine pregnancy-associated glycoprotein (cPAG) concentrations and fetal number was investigated in 21 nulliparous and 17 multiparous goats. Using a homologous ... [more ▼]

The relationship between maternal caprine pregnancy-associated glycoprotein (cPAG) concentrations and fetal number was investigated in 21 nulliparous and 17 multiparous goats. Using a homologous radioimmunoassay (hm-RIA) cPAG was detected in plasma of pregnant goats from the 21st day of pregnancy. Statistical differences between goats bearing single and multiple fetuses were observed after 63 days to the end of pregnancy, except on day 133. After 126 days (3rd week pre-partum) cPAG levels began to decrease slowly in both the groups. The hm-RIA was an efficient method to describe the relationship between maternal PAO concentrations and number of fetuses in goats. (C) 2001 Published by Elsevier Science B.V. [less ▲]

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See detailObituary : R.H. HARRIS ( Soul Stirrers, ....)
Sacré, Robert ULg

in Soul Bag (2001), (161), 33

Rebert H. HARRIS 1916- 2000 - chanteur lead des Soul Stirrers

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See detailLa guerre et la medecine d'une culture de paix. 1. Quand s'ouvrent les portes du temple de janus
Pierard, Gérald ULg

in Revue Médicale de Liège (2001), 56(11), 785-7

More than 40 major wars took place during the past decade. The origins and the warlike means that were engaged were very different from those of older conflicts. Wars between nations are less numerous ... [more ▼]

More than 40 major wars took place during the past decade. The origins and the warlike means that were engaged were very different from those of older conflicts. Wars between nations are less numerous. They have been replaced by civilian wars that are more rooted on cultural and religious grounds than on economic interests alone. During this short period of time, warfare was responsible for about 2 millions of direct deaths and 20 millions displaced people and refugees. The injured and victims of starvation and epidemics were innumerable and awaited for civilian medical help. [less ▲]

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