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See detailDistribution of Aromatase-Immunoreactive Cells in the Mouse Forebrain
Balthazart, Jacques ULg; Foidart, Agnès ULg; Surlemont, C. et al

in Cell & Tissue Research (1991), 263(1), 71-9

The distribution of aromatase-immunoreactive cells was studied by immunocytochemistry in the mouse forebrain using a purified polyclonal antibody raised against human placental aromatase. Labeled ... [more ▼]

The distribution of aromatase-immunoreactive cells was studied by immunocytochemistry in the mouse forebrain using a purified polyclonal antibody raised against human placental aromatase. Labeled perikarya were found in the dorso-lateral parts of the medial and tuberal hypothalamus. Positive cells filled an area extending between the subincertal nucleus in the dorsal part, the ventromedial hypothalamic nucleus in the ventral part, and the internal capsule and the magnocellular nucleus of the lateral hypothalamus in the lateral part. The same distribution was seen in the two strains of mice that were studied (Jackson and Swiss), and the number of immunoreactive perikarya did not seem to be affected by castration or testosterone treatment. No immunoreactivity could be detected in the medial regions of the preoptic area and hypothalamus; these were expected to contain the enzyme based on assays of aromatase activity performed in rats and on indirect autoradiographic evidence in mice. Our data raise questions concerning the distribution of aromatase in the brain and the mode of action of the centrally produced estrogens. [less ▲]

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See detailSous-groupes libres dans les groupes d’automorphismes d’arbres
Pays, Isabelle ULg; Valette, Alain

in L'enseignement mathématique (1991), 37

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See detailLes indices d'activité dans la maladie de Crohn
Belaiche, Jacques ULg; Louis, Edouard ULg; Delwaide, Jean ULg et al

in Revue Médicale de Liège (1991), 46(1), 11-5

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See detailLes nouveaux dérivés de la salazosulfapyridine dans le traitement de la maladie de Crohn
Belaiche, Jacques ULg; Delwaide, Jean ULg; Louis, Edouard ULg et al

in Revue Médicale de Liège (1991), 46(1), 16-22

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See detailMagnetic Stimulation of the Motor Cortex in Cervical Spondylosis
Maertens De Noordhout, Alain ULg; Remacle, J. M.; PEPIN, Jean-Louis ULg et al

in Neurology (1991), 41(1), 75-80

We report a new technique of transcranial magnetic stimulation of the motor cortex to measure conduction within central motor pathways of 67 patients with cervical spondylosis or disk herniation. There ... [more ▼]

We report a new technique of transcranial magnetic stimulation of the motor cortex to measure conduction within central motor pathways of 67 patients with cervical spondylosis or disk herniation. There were upper motor neuron signs in 34 patients (51%) and x-ray evidence of cervical cord compression in 44 (66%). Muscle action potentials (MAPs) to cortical stimulation were abnormal in 84% of patients with, and 22% of those without, radiologic signs of cervical cord compression. Median nerve somatosensory evoked potentials were altered in only 25% of patients. The frequency of MAP alterations correlated with upper motor neuron signs. In 5 (11%) of the 44 patients with x-ray evidence of cervical cord compression, subclinical cord compression was disclosed by cortical stimulation. In 10 patients restudied 3 months after surgical decompression, normalization of central motor conduction time did not occur, indicating permanent damage to the cervical cord. [less ▲]

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See detailAspects immunologiques actuels de la maladie de Crohn
Louis, Edouard ULg; Belaiche, Jacques ULg; Gast, Pierrette ULg et al

in Revue Médicale de Liège (1991), 46(1), 2-11

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See detailNotes sur la dégradabilité dans le rumen de 6 aliments riches en matières grasses
Dufrasne, Isabelle ULg; Istasse, Louis ULg; Van Eenaeme, Christian ULg et al

in Revue de l’Agriculture = Landbouwtijdschrift (1991), 44(1), 31-38

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See detailTraitement immunosuppresseur et maladie de Crohn
Delwaide, Jean ULg; Louis, Edouard ULg; Gast, Pierrette ULg et al

in Revue Médicale de Liège (1991), 46(1), 22-8

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See detailMacromolecular engineering of lactone-based (co)polymers for biomedical applications
Dubois, Philippe ULg; Grandfils, Christian ULg; Jérôme, Robert ULg et al

in Polymer Chemistry (1991), 32 (1)

Ring-opening polymerization of epsilon-caprolactone and lactides by aluminum alkoxides allows aliphatic polyesters to be tailored at will and fitted to requirements for biomedical applications ... [more ▼]

Ring-opening polymerization of epsilon-caprolactone and lactides by aluminum alkoxides allows aliphatic polyesters to be tailored at will and fitted to requirements for biomedical applications, particularly for controlled drug delivery systems. Variation in molecular weight controls the effective life time of microspheres or implants in vivo. Block copolymerization leads to microphase separated materials and opportunity to modify the overall release kinetics and to get, for instance, a zero-order. Macromonomers and dimacromonomers are ideal precursors for physically and chemically stabilized hydrogels, respectively. Dimacromonomers can actually generate amphiphilic networks. [less ▲]

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See detailAdult respiratory distress syndrome: local or systemic disease
Deby, Ginette ULg; Lamy, Maurice ULg; Deby, C. et al

in Critical Care (1991), 4(1), 57-83

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See detailStructure and Beneficiation of a rich gold ore
Ek, Corneille; Pirard, Eric ULg; Baguette, Luc

in ATB Métallurgie (1991), 1-2

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See detailMultiple domains of the glucocorticoid receptor involved in synergism with the CACCC box factor(s).
Muller, Marc ULg; Baniahmad, C.; Kaltschmidt, C. et al

in Molecular Endocrinology (Baltimore, Md.) (1991), 5(10), 1498-503

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy ... [more ▼]

Steroid induction of responsive genes functions through the synergistic activity of steroid receptor-binding sequences with adjacent transcription factor-binding sites. To analyze the mechanism of synergy we tested different human glucocorticoid receptor mutants for synergistic function with another transcription factor in comparison with intrinsic trans-activation obtained with a single receptor binding site (glucocorticoid response element). Multiple domains were found to be involved in synergistic activity of the glucocorticoid receptor with the CACCC box factor. Deletions within the N-terminal receptor half affected simultaneously intrinsic trans-activation and synergism. However, deletion of the hormone-binding domain mainly impaired synergism rather than intrinsic trans-activation, clearly showing that this domain synergizes by a mechanism independent of intrinsic activation. A chimeric protein where the DNA-binding domain of the glucocorticoid receptor was replaced by that of the yeast GAL4 protein also showed functional synergism. These data suggest that some of the receptor domains outside the DNA-binding domain synergize by their intrinsic trans-activating property, but the hormone-binding domain contributes to synergism by a different mechanism. [less ▲]

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See detailQu'attendre de l'échographie mammaire?
COLIN, Claude; LIFRANGE, Eric ULg; EVRAUD, Ginette et al

in Contraception, Fertilité, Sexualité (1991), 19(n°4), 320-323

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See detailChemical anatomy of the spinal cord
Schoenen, Jean ULg

in Neurologic Clinics (1991), 9

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See detailIn situ nick translation at the electron microscopic level: a tool for studying the location of DNAse I-sensitive regions within the cell.
Thiry, Marc ULg

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1991), 39(6), 871-4

The in situ nick translation method was adapted to the ultrastructural level, to study the location of DNAse I-sensitive sequences within the cell. Ultra-thin sections of Lowicryl-embedded cells were ... [more ▼]

The in situ nick translation method was adapted to the ultrastructural level, to study the location of DNAse I-sensitive sequences within the cell. Ultra-thin sections of Lowicryl-embedded cells were incubated in a medium containing DNAse I, DNA polymerase I, and all four deoxyribonucleotides, some being biotinylated. The nick-translated sites were then visualized by an indirect immunogold labeling technique. The resulting labeling pattern is closely dependent on the DNAse I concentration in the nick-translation medium. The method reveals with great precision the specific DNAse I-sensitive regions within the nucleus. This technique can be used to discriminate between active and inactive regions of interphase chromatin. [less ▲]

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See detailTumeurs developpees apres ureterosigmoidostomie (U.S.S.). Revue de la litterature a propos de deux cas cliniques.
Nicolas, H.; Bonnet, Pierre ULg; Vandeberg, Colette ULg et al

in Acta Urologica Belgica (1991), 59(4), 73-82

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See detailProtéases et inhibiteurs de protéases : implications multiples dans le développement et le vieillissement cérébral
Leprince, Pierre ULg; Rogister, Bernard ULg; Delrée, Paul et al

in Revue d'Oto-Neuro-Ophtalmologie (1991), 12(13), 30-38

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See detailErythropoïétine : utilisation diagnostique et thérapeutique
Beguin, Yves ULg; Fillet, Georges ULg

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (1991), 18(3), 161-168

L'érythropoïétine est une hormone produite par le rein en réponse à une hypoxie rénale et qui stimule l'activité érythropoïétique de la moelle osseuse. Le dosage de l'érythropoïétine sérique, toujours ... [more ▼]

L'érythropoïétine est une hormone produite par le rein en réponse à une hypoxie rénale et qui stimule l'activité érythropoïétique de la moelle osseuse. Le dosage de l'érythropoïétine sérique, toujours interprété en fonction de l'hématocrite circulant, est utile dans le diagnostic différentiel des polyglobulies et dans certains cas particuliers d'anémie. L'utilisation thérapeutique de l'érythropoïétine recombinante a permis de corriger l'anémie de l'insuffisance rénale chronique et est actuellement étudiée dans d'autres indications telles que les anémies inflammatoires. [less ▲]

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See detailCloning and characterization of a cDNA encoding the bovine insulin-like growth factor binding protein 1 (bIGFBP-1).
Sneyers, M.; Kettmann, Richard ULg; Massart, Serge et al

in DNA Sequence : The Journal of DNA Sequencing & Mapping (1991), 1(6),

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See detailIntérêt de l'enfant et paiement des pensions alimentaires après divorce en Belgique
Bawin-Legros, Bernadette; Gauthier, Anne; Guillaume, Jean-François ULg

in Population : Revue Trimestrielle de l'Institut National d'Etudes Démographiques (1991), 4

This paper is a study of parental behaviour, and more particularly that of fathers, after divorce, in which findings from a national survey carried out in Belgium are used. The payment of alimony is ... [more ▼]

This paper is a study of parental behaviour, and more particularly that of fathers, after divorce, in which findings from a national survey carried out in Belgium are used. The payment of alimony is considered to be not solely a financial solution, but as an indication of a certain acceptance of parental responsibility which is rooted in the marriage and family background that existed before the couple separated. Legal practise, which generally gives care and control of the child to the mother, also results in the continuity of the traditional type of the division of labour between the parents after their marriage has broken down. This supports the moral principle of a privileged mother-child relationship, but may also lead to a deterioration in the living standards of the mothers' households. [less ▲]

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See detailObservations ultraviolettes des planètes géantes et de leurs satellites à l'aide du Télescope Spatial Hubble
Gérard, Jean-Claude ULg; Dols, Vincent

in Nouvelles de la Science et des Technologies (1991)

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See detailPotentialités de l'application de l'oxymétrie à infra-rouge basée sur la pulsation dans l'espèce canine
Lemaire, M.; Art, Tatiana ULg; Henroteaux, Marc ULg et al

in Annales de Médecine Vétérinaire (1991), 135

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See detailNew hypothesis on the conformation of the PAF receptor from studies on the geometry of selected platelet-activating-factor antagonists
Batt, Jean-Pierre; Lamouri, Aazdine; Tavet, Fabrice et al

in Journal of Lipid Mediators (1991), 4(3), 343-346

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See detailMean Fluxes Across Sections in the Mediterranean Sea Derived from GCM results
Stanev, E.; Beckers, Jean-Marie ULg

in Journal of Marine Systems (1991), 1

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See detailCytochemical distinction of various nucleolar components in insect cells.
Thiry, Marc ULg; Schoonbroodt, Stéphanie ULg; Goessens, Guy ULg

in Biology of the Cell (1991), 72(1-2), 133-40

The fine structure of the insect Sf9 cell nucleolus has been investigated by means of different cytochemical and immunocytochemical techniques at the electron microscope level. Apart from a few ... [more ▼]

The fine structure of the insect Sf9 cell nucleolus has been investigated by means of different cytochemical and immunocytochemical techniques at the electron microscope level. Apart from a few perinucleolar condensed chromatin clumps, the insect cell nucleolus comprises two compartments. The first of these consists of a roundish compact zone formed of fibrillar material. The other is composed of fibrillar and granular structures organized into a network separated by interstitial spaces. But, unlike mammalian cell nucleoli, any fibrillar center has been observed in the Sf9 cell nucleolus, even after actinomycin D treatment. We also show that the compact fibrillar zone of Sf9 cell nucleoli contains silver-stainable material and DNA. In actinomycin D-treated cells, a preferential contact of this compact fibrillar zone with condensed chromatin has been visualized. Finally, silver-stainable material has been found to persist throughout the whole mitosis. These results suggest that the compact fibrillar zone at the insect Sf9 cell nucleolus should, at least partly, correspond to the fibrillar center of mammalian cell nucleoli. [less ▲]

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See detailHierarchy and scales in marine ecohydrodynamics
Nihoul, Jacques ULg; Djenidi, Salim ULg

in Earth-Science Reviews (1991), 31(3-4), 255-277

Recent investigations reveal, in marine ecosystems, an ecohydrodynamic hierarchical organization resulting from the different rates of ecological processes confronted to a multi-scale physical environment ... [more ▼]

Recent investigations reveal, in marine ecosystems, an ecohydrodynamic hierarchical organization resulting from the different rates of ecological processes confronted to a multi-scale physical environment. Major marine hydrodynamic processes are briefly analyzed here in an ecohydrodynamic perspective, emphasizing the effects they have on ecosystems at different levels of hierarchy and identifying appropriate “spectral windows” for modelling. A case study application to the Northern Bering Sea's Summer Ecohydrodynamics is given in illustration. [less ▲]

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See detailLocalization of nucleolar chromatin by immunocytochemistry and in situ hybridization at the electron microscopic level.
Thiry, Marc ULg; Scheer, U.; Goessens, Guy ULg

in Electron Microscopy Reviews (1991), 4(1), 85-110

Nucleoli are the morphological expression of the activity of a defined set of chromosomal segments bearing rRNA genes. The topological distribution and composition of the intranucleolar chromatin as well ... [more ▼]

Nucleoli are the morphological expression of the activity of a defined set of chromosomal segments bearing rRNA genes. The topological distribution and composition of the intranucleolar chromatin as well as the definition of nucleolar structures in which enzymes of the rDNA transcription machinery reside have been investigated in mammalian cells by various immunogold labelling approaches at the ultrastructural level. The precise intranucleolar location of rRNA genes has been further specified by electron microscopic in situ hybridization with a non-autoradiographic procedure. Our results indicate that the fibrillar centers are the sole nucleolar structures where rDNA, core histones, RNA polymerase I and DNA topoisomerase I are located together. Taking into account the potential value and limitations of immunoelectron microscopic techniques, we propose that transcription of the rRNA genes takes place within the confines of the fibrillar centers, probably close to the boundary regions to the surrounding dense fibrillar component. [less ▲]

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See detailA method to compute reactive power margins with respect to voltage collapse
Van Cutsem, Thierry ULg

in IEEE Transactions on Power Systems (1991), 6

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See detailLa séance d'éducation physique avec medecine ball
Vanderthommen, Marc ULg

in Revue de l'Education Physique (1991), 31(3), 127-132

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See detailEffects of different calcium formulations on calcium absorption in healthy volunteers
Reginster, Jean-Yves ULg; DEROISY, Rita ULg; Franchimont, P

in Advances in Therapy (1991), 8(2), 86-91

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See detailDigital three-dimensional visualization of cellular organelles studied by medium- and high-voltage electron microscopy.
Beorchia, A.; Ploton, D.; Menager, M. et al

in Journal of Microscopy (1991), 163(Pt 2), 221-31

Tilted thick sections (one-half to several micrometers) of biological specimens observed with medium- to high-voltage electron microscopes are extremely useful for the study of the three-dimensional (3-D ... [more ▼]

Tilted thick sections (one-half to several micrometers) of biological specimens observed with medium- to high-voltage electron microscopes are extremely useful for the study of the three-dimensional (3-D) structure of organelles. If high resolution in 3-D visualization and 3-D reconstruction is needed, many images corresponding to various angles of rotation and tilt must be recorded. This necessitates very time-consuming work--including eventual photographic processing--before good positioning of the object is defined. We have developed software which permits very rapid and precise determination of the tilt-axis, the registration of tilted views, 3-D measurements and 3-D visualization. Images are digitized either from negative films or directly with a camera fitted to the microscope. The application of the software is performed in minutes and allows for a rapid check of the quality of the tilt-series and of the features of interest of the object. Application of the software to the study of the 3-D structure of active components of the nucleolus stained with silver is shown. [less ▲]

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See detailUne évolution inéluctable
Reginster, Jean-Yves ULg

in Jeune Pratique (1991), 50

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See detailDNase I-sensitive sites within the nuclear architecture visualized by immunoelectron microscopy.
Thiry, Marc ULg

in DNA & Cell Biology (1991), 10(3), 169-80

Nick-translation using mild digestion with DNase I allows preferential labeling of actively transcribing or potentially active genes, as compared with inactive genes. We have adapted this method to the ... [more ▼]

Nick-translation using mild digestion with DNase I allows preferential labeling of actively transcribing or potentially active genes, as compared with inactive genes. We have adapted this method to the level of electron microscopy to see the DNase I-sensitive regions in situ in Ehrlich tumor cells. In interphase cells treated with very low concentrations of DNase I, labeled sequences are found at the borders and in the close vicinity of condensed chromatin blocks. Labeling of condensed areas of chromatin requires higher DNase I concentrations and longer incubation in the nick-translation medium. In the nucleolus, the first sites to be nick-translated are the fibrillar centers and the interstices surrounding them, whereas the dense fibrillar component never contains labeled sequences. When cells are pretreated with actinomycin D, only a few perinucleolar clumps of condensed chromatin are labeled under the same conditions. This method provides a new tool for studying the functional organization of chromatin within a cell. The precise location of nick-translated sites in nucleolar components observed could change classical views concerning the functional organization of the nucleolus. [less ▲]

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See detailSynthesis of high specificity tritium labelled chloroethylcyclohexylnitrosourea and its application to the study of DNA modification
Siew, E.; Habraken, Yvette ULg; Ludlum, D.

in Journal of the radiolabelled compounds and radiopharmaceuticals (1991), XXIX

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See detailVelogenetics or the synergistic use of Marker Assisted Selection and Germ-Line Manipulation
Georges, Michel ULg; Massey, J. M.

in Theriogenology (1991), 35(1), 151-156

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See detailAllergic cross-reaction of teicoplanin and vancomycin
Grek, V.; Andrien, F.; Collignon, J. et al

in Journal of Antimicrobial Chemotherapy (1991), 28

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See detailLes Pachytheca de La Gileppe et de Nonceveux (Dévonien inférieur de Belgique)
Gerrienne, Philippe ULg

in Annales de la Société Géologique de Belgique (1991), 113

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See detailStructure de la bétaïne du carboxyméthyl-1 méthylamino-4 triazolium-1,2,4
Dupont, L.; Englebert, S.; Dideberg, O. et al

in Acta Crystallographica (1991), C47

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See detailEffets du blocage des recepteurs beta-adrenergiques sur l'hyperlactacidemie induite par des exercices d'intensites differentes.
Scheen, André ULg; Camus, G.; Fossion, Anny ULg

in Archives Internationales de Physiologie, de Biochimie et de Biophysique (1991), 99(4), 331-4

The effects of beta-adrenergic blockade on the exercise-induced hyperlactatemia (Lap) have been studied in 31 adult male subjects [age: 25 +/- 1 years; body weight: 69 +/- 1 kg; VO2max: 54 +/- 1 ml O2.kg ... [more ▼]

The effects of beta-adrenergic blockade on the exercise-induced hyperlactatemia (Lap) have been studied in 31 adult male subjects [age: 25 +/- 1 years; body weight: 69 +/- 1 kg; VO2max: 54 +/- 1 ml O2.kg-1.min-1 (mean values +/- SEM)] randomly divided in 3 groups. All exercises were performed on a 10% inclined treadmill. In group 1 (n = 11), the subjects were walking during 20 minutes at 5 km.h-1 (55.6 +/- 1.4% VO2max). In group 2 (n = 10), they were running during 9 minutes at 8 km.h-1 (79.4 + 1.5% VO2max). The subjects of the third group (n = 10) were submitted to a 4 minutes run at 9.5 km.h-1 92 +/- 1.6% VO2max). These exercises were performed 1 hour after ingestion of a placebo or a single dose of 40 mg propranolol, in a double-blind randomized order. Blood samples were drawn at regular time intervals from an antecubital vein. Exercise tachycardia was reduced by about 20% (P less than 0.001) by propranolol in each group. Lap was significantly reduced by 15% by propranolol (P less than 0.005) at the lowest exercise intensity (55.6% VO2max), remained unchanged at 79.4% VO2max and was significantly enhanced by 16% during the recovery period following the run at 92% VO2max. These results clearly showed that the effects of acute beta-adrenergic blockade on Lap depend on exercise intensity. [less ▲]

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See detailAbcès thyroïdien a streptocoque pneumoniae associé à un goitre nodulaire toxique. A propos d'un cas
Panas, N.; Zgheib, A.; Desaive, Claude ULg et al

in Semaine des Hôpitaux de Paris (La) (1991), 34

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic ... [more ▼]

An unusual case of acute suppurative thyroiditis in association with toxic nodular goiter is reported by the authors. Surgical therapy was necessary due to the severity of the local and systemic inflammation induced by this association. [less ▲]

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See detailÉtude hydrodynamique d'un fermenteur airlift adapté pour le mode de fonctionnement fed-batch
Groslambert, Sylvie ULg; Schlitz, Marc; Crine, Michel ULg

in Récents Progrès en Génie des Procédés (1991), 5(16), 11-16

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See detailStructure de l'acide (tert-butylamino-4 oxo-5 triazol-1,2,4 yle-1)acétique
Dupont, L.; Englebert, S.; Dideberg, O. et al

in Acta Crystallographica (1991), C47

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See detailL'agriculture dans la Province du Luxembourg
Burny, Philippe ULg

in Annales de Gembloux (1991), 97(1), 43-67

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See detailUptake kinetic of medium constituants during batch growth of patatoe cell cultures.
Gerard, J.; Antoine, P.; Lepoivre, Philippe ULg et al

in Biotechnology Letters (1991), 13(5), 381-384

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See detailA Note On The Rate Of Passage Of Digesta In Pigs Ileo-Rectostomized Or Fitted With An Ileal T-Cannula
Leterme, Pascal; Pirard, L.; Thewis, André ULg et al

in Animal Production (1991), 53(2), 253-256

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See detailEssai de discrimination du tissu urbain par segmentation d'image
Collette, Bénédicte; Nadasdi, Istvan; Donnay, Jean-Paul ULg

in Mappemonde (1991), (4), 31-35

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See detailScale economies and performances in the French Insurance Industry
Fecher-Bourgeois, Fabienne ULg; Kessler, D.; Pestieau, Pierre ULg et al

in Geneva Papers on Risk & Insurance - Issues & Practice (1991), (60),

The purpose of this paper is to provide for both life and non life insurance a measurement of economies of scale and an assessment of productive performance of French companies. We use a translog cost ... [more ▼]

The purpose of this paper is to provide for both life and non life insurance a measurement of economies of scale and an assessment of productive performance of French companies. We use a translog cost function to check the presence of scale economies and a parametric approach to construct our yardstick of productive efficiency. Our panel data covers 84 life and 243 non life companies for the period 1984–89. The main findings indicate both the existence of increasing returns to scale and a wide dispersion in the rates of inefficiency across companies. Those two results are shown to be closely linked to a number of characteristics of the companies studied, particularly their institutional form. [less ▲]

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See detailHydrolysate preparation and comparative amino acid determination by cation-exchange and gas-liquid chromatography in diet ingredients
De Schrijver, Ronny; Van Eenaeme, Christian ULg; Fremaut, D. et al

in Cerevisia and Biotechnology (1991), 16(4)

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See detailEvidence of West European defined miospore zones in the Uppermost Devonian and Lower Carboniferous of the Amazonas Basin (Brazil).
Loboziak, S; Streel, Maurice ULg; Caputo, M.V. et al

in Geobios (1991), 24(1), 5-11

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See detailSiderophores production and Enhancement by optimization of culture conditions and transposon-mutagenesis of a fluorescent Pseudomonas.
Delfosse, Ph; Jacques, Ph; Moussaif, M. et al

in Archives Internationales de Physiologie et de Biochimie (1991), 99(B55),

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See detailBeams and Jets in Astrophysics -- Philip A. Hughes
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailEtude sur les fluctuations de température relevées dans 20 compartiments de maternité en porcherie d'élevage
Debliquy, P.; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1991)

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See detailLa surveillance de l'état de l'environnement wallon par bioindicateurs.
Goffart, Philippe; Dufrêne, Marc ULg; Marchal, Didier

in Gomphus (1991), 7

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See detailMatadine, a cytotoxic alkaloid from Strychnos gossweileri
Quetin-Leclercq, Joëlle; Coucke, P.; Delaude, Clément et al

in Phytochemistry (1991), 30(5), 1697-1700

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on ... [more ▼]

Matadine, a new alkaloid, has been isolated from the root bark of Strychnos gossweileri. Elucidation of its structure is mainly based on 1H and 1D NMR studies. Its cytotoxic activity has been tested on cancer cells and normal cells. Matadine is an anhydronium base as serpentine, that exerts also a selective inhibiting activity on B16 melanoma cells while it is less toxic in human 2002 non-cancer cells. This selective activity might be well due , as it seems to be the case for serpentine and alstonine, to a higher affinity of matadine for destabilized single-stranded DNA as mainly present in cancer cells. [less ▲]

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See detailInduction expérimentale de la pneumonie pasteurellique chez la chèvre : étude des modifications physiopathologiques
Bakima, M.; Kaeckenbeeck, A.; Meniai, K. et al

in Annales de Médecine Vétérinaire (1991), 135

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See detailFantaisie verbale chez quelques monologuistes francophones
Defays, Jean-Marc ULg

in Bulletin Francophone de Finlande (1991), (7), 75-85

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See detailCytokines et choc septique
Lamy, Maurice ULg; Damas, Pierre ULg

in Bulletin de l'Académie Royale de Médecine de Belgique (1991), 146(6-7), 270

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See detailTransient T and B cell activation after neonatal induction of tolerance to MHC class II and Mls alloantigens
Schurmans, Stéphane ULg; Brighouse, G.; Kramar, G. et al

in Journal of Immunology (1991), 146

The neonatal injection of semiallogeneic F1 spleen cells into newborn parental mice results in the induction of tolerance to the corresponding alloantigen (alloAg) and chimerism. In these F1 cell-injected ... [more ▼]

The neonatal injection of semiallogeneic F1 spleen cells into newborn parental mice results in the induction of tolerance to the corresponding alloantigen (alloAg) and chimerism. In these F1 cell-injected mice, we have previously observed that this state of specific tolerance is associated with the development of a transient lupus-like autoimmune syndrome. In this study, we show that neonatal injection of mice with spleen cells differing from the host at major histocompatibility complex (MHC) class I, class II, class (I + II), or minor lymphocyte stimulating (Mls) alloAg induced a state of specific tolerance characterized by the absence of alloreactive CTL and/or Th cell responses in the spleen and the thymus of 6- to 12-week-old injected mice. However, in mice rendered tolerant to MHC class II or class (I + II) alloAg, the presence of high levels of IgG1 antibodies, of circulating immune complexes, of anti-ssDNA autoantibodies, and of tissue lesions were transiently observed. In these mice, an increased Ia Ag expression on lymphoid spleen cells was also detected at 1 wk. The elevated production of IgG1 and the overexpression of Ia Ag were almost completely prevented by treatment with an anti-IL-4 mAb. Such manifestations of B cell activation and autoimmunity were not observed in mice neonatally injected with F1 cells differing from the host only at MHC class I Ag. In mice neonatally tolerized to Mls Ag, a transient increase in IgG2a production and an overexpression of Ia Ag were detected without features of autoimmunity, and were prevented by anti-INF-gamma mAb treatment. In mice rendered tolerant to MHC class II, class (I + II), or Mls alloAg at birth, the manifestations of B cell activation were associated with the presence of in vivo-activated alloreactive CD4+ T cells in the spleen--but not the thymus--of 1-wk-old injected mice. Together, these results suggest that in mice neonatally injected with semiallogeneic F1 cells, the process of tolerance induction is not efficient during the early postnatal period, and could allow the maturation and peripheralization of some alloreactive CD4+ T cells, leading to transient B cell activation and, depending on the alloAg, to autoimmunity [less ▲]

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See detailItaly : two Perspectives. Racism in Paradise ?
Martiniello, Marco ULg; Kazim, P.

in Race & Class (1991), 32(3), 79-89

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See detailDoes environmental exposure to cadmium represent a health risk? Conclusions from the Cadmibel Study.
Lauwerys, R.; Bernard, A.; Buchet, J.-P. et al

in Acta Clinica Belgica (1991), 46

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See detailChampion (Emptinne, Nr), Villa romaine (signalement archéologique)
Longrée, Dominique ULg; Breyer, Catherine; De Poorter, Alexandra

in Vie archéologique (1991), 36

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See detailThe evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins
Bellefroid, Eric J; Poncelet, Dominique A; Lecocq, Pierre J et al

in Proceedings of the National Academy of Sciences of the United States of America (1991), 88(9), 3608-12

We have previously shown that the human genome includes hundreds of genes coding for putative factors related to the Kruppel zinc-finger protein, which regulates Drosophila segmentation. We report herein ... [more ▼]

We have previously shown that the human genome includes hundreds of genes coding for putative factors related to the Kruppel zinc-finger protein, which regulates Drosophila segmentation. We report herein that about one-third of these genes code for proteins that share a very conserved region of about 75 amino acids in their N-terminal nonfinger portion. Homologous regions are found in a number of previously described finger proteins, including mouse Zfp-1 and Xenopus Xfin. We named this region the Kruppel-associated box (KRAB). This domain has the potential to form two amphipathic alpha-helices. Southern blot analysis of "zoo" blots suggests that the Kruppel-associated box is highly conserved during evolution. Northern blot analysis shows that these genes are expressed in most adult tissues and are down-regulated during in vitro terminal differentiation of human myeloid cells. [less ▲]

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See detailEtude lithostratigraphique, biostratigraphique et sédimentologique du sondage de Lessines (bord méridional du Massif de Brabant, Belgique)
Herbosch, A.; Vanguestaine, M.; Degardin, J. M. et al

in Anales de la société géologique de belgique (1991), 114

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See detailSequence analysis of the ARG7 gene of Schizosaccharomyces pombe coding for argininosuccinate lyase. Expression of the gene in Saccharomyces cerevisiae.
Loppes, Roland ULg; Michels, R; Decroupette, I et al

in Current Genetics (1991), 19(4), 255-60

The complete nucleotide sequence of the ARG7 gene, coding for argininosuccinate lyase (EC 4.3.2.1), in the fission yeast (Schizosaccharomyces pombe) has been determined. It consists of an open reading ... [more ▼]

The complete nucleotide sequence of the ARG7 gene, coding for argininosuccinate lyase (EC 4.3.2.1), in the fission yeast (Schizosaccharomyces pombe) has been determined. It consists of an open reading frame of 461 codons. The deduced protein has a molecular weight of 51,200 Da. The gene is devoid of introns which is confirmed by the fact that it is expressed in Escherichia coli after spontaneous insertion of a bacterial sequence probably bearing a prokaryotic promoter. A perfect "TATA" box is found at -72 and the major transcription initiation site in Saccharomyces cerevisiae is located at -11 as shown by primer extension experiments. Comparison of the S. pombe lyase with related proteins from other organisms reveals an important degree of conservation except in the carboxyterminal part of the polypeptide. Additionally, a deletion removing 66 amino acids of the carboxy terminus yields an enzyme exhibiting some biological activity. A unique 1,500 b transcript was found in S. cerevisiae when the intact gene was present, but the deleted version of the gene gave rise to at least three transcripts of 1,800, 2,800 and 3,900 b. [less ▲]

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See detailUn cas de syndactylie chez le chien
RENOY, Philippe ULg; Balligand, Marc ULg

in Annales de Médecine Vétérinaire (1991)

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See detailProduction and purification of biologically active recombinant tilapia (Oreochromis niloticus) prolactins
Swennen, D.; Rentier-Delrue, Françoise ULg; Auperin, B. et al

in Journal of Endocrinology (1991), 131(2), 219-27

Recombinant expression vectors carrying tilapia prolactin-I or -II (tiPRL-I or tiPRL-II) cDNA were constructed and the tiPRL-I and II proteins were produced in E. coli as inclusion bodies. These inclusion ... [more ▼]

Recombinant expression vectors carrying tilapia prolactin-I or -II (tiPRL-I or tiPRL-II) cDNA were constructed and the tiPRL-I and II proteins were produced in E. coli as inclusion bodies. These inclusion bodies were dissolved in 6 mol urea/l. Refolding of the proteins was followed by SDS-PAGE under non-reducing conditions so as to visualize the oxidized state of the molecules. Proteins tiPRL-I and tiPRL-II were purified by gel filtration and ion-exchange chromatography. The N-terminal sequence and bioactivities of both purified proteins were then analysed. Recombinant tiPRL-I and tiPRL-II induced a significant rise in plasma calcium levels as well as in mucocyte density in the abdominal skin epithelium. When tested on kidney membrane, both proteins exhibited potency in competing with 125I-labelled tiPRL-I for binding sites, but tiPRL-I seemed to be more potent than tiPRL-II in competing for these sites. The results obtained for the biological activities tested suggest that both recombinant prolactins were correctly refolded and had retained the full biological activity previously observed with the natural hormone preparations extracted from the animals. [less ▲]

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See detailNouvelles données sur la bande de Sambre-et-Meuse à Ombret (Huy, Belgique)
Hance, Luc ULg; Steemans, Philippe ULg; Goemaere, E et al

in Annales de la Société Géologique de Belgique (1991), 114(1), 253--264

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See detailThe Solar System -- T. Encrenaz, J. -P. Birbing et M. Blanc
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailExercices in practical Astronomy using photographs: with solutions -- Mary Teresa Brück
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailTruncal Vagotomy and Pyloroplasty Combined with Valvular Replacement in Patients with Ulcer Disease
Defraigne, Jean-Olivier ULg; Innocenti, C.; DEKOSTER, Guy ULg et al

in Journal of Cardiovascular Surgery (The) (1991), 32(1), 42-5

In 1988, 5 patients (3 men and 2 women) with ulcer disease (mean age 56 +/- 8 years) underwent valvular replacement for aortic (No. = 4) or mitral disease (No. = 1). All patients had had gastroduodenal ... [more ▼]

In 1988, 5 patients (3 men and 2 women) with ulcer disease (mean age 56 +/- 8 years) underwent valvular replacement for aortic (No. = 4) or mitral disease (No. = 1). All patients had had gastroduodenal ulcers. Preoperative gastroscopy demonstrated active ulcers (No. = 4) and a healed pyloric ulcer with pyloric stenosis (No. = 1). Despite the presence of ulcers, a non-biologic prosthesis was preferred in each patient because of their young age (No. = 3), chronic atrial fibrillation requiring anticoagulant therapy (No. = 1), and refusal of the eventuality of subsequent reoperation (No. = 1). In each patient, a truncal vagotomy with pyloroplasty was performed simultaneously with the valvular procedures by the same incision. The postoperative courses were uneventful. With a mean follow-up of 15 +/- 3 months, no gastrointestinal bleeding was observed during anticoagulant therapy. With anticoagulant drugs, bleeding may occur with a frequency of 4% per patient treatment-year, half of which are gastrointestinal in origin. Nevertheless, in selected patients with gastroduodenal ulcers, performing a vagotomy-pyloroplasty simultaneously with valvular replacement allows implantation of a non-biologic prosthesis, with greater durability than bioprosthesis. [less ▲]

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See detailPhotoionization Mass Spectrometry of Kinetic energy-selected ions. An Ion Retarding Potential Difference method applied to NO+ and O+ from N2O.
Locht, Robert ULg; Hagenow, G.; Hottmann, K. et al

in Chemical Physics (1991), 151

A new method is described to obtain photoionization efficiency curves of kinetic energy-selected fragment ions. The method is tested and discussed in the case of the dissociative photoionization yields of ... [more ▼]

A new method is described to obtain photoionization efficiency curves of kinetic energy-selected fragment ions. The method is tested and discussed in the case of the dissociative photoionization yields of NO+ and O+ from N2O. The attention is focussed on the dissociative autoionization processes in the threshold region, in the Franck-Condon region of the N2O(A2Sigma+) state and in the Franck-Condon gap between the A2Sigma+ and B2Pi states. [less ▲]

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See detailGeographic structure and potential ecological factors in Belgium
Dufrêne, Marc ULg; Legendre, P.

in Journal of Biogeography (1991), 18(3), 257-266

The available potential ecological factors have been scored in the form of presence/absence in Universal Transverse Mercator (UTM) squares in Belgium. A correspondence analysis shows a strong underlying ... [more ▼]

The available potential ecological factors have been scored in the form of presence/absence in Universal Transverse Mercator (UTM) squares in Belgium. A correspondence analysis shows a strong underlying gradient in the data set which induces an extraordinary horseshoe effect. This gradient follows closely the altitude component. Applying the k-means clustering method on UTM squares produced geographically compact groups which are largely hierarchically nested. This indicates strong regional trends in the ecological data set. As homogeneous groups may also be artefacts created by the clustering algorithms on a continuous gradient, the relevance of the borders between homogeneous areas is tested. In general, k-means borders correspond to the main breaking lines between adjacent UTM squares. They can be referred to as natural borders. -Authors [less ▲]

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See detailPour comprendre l'univers -- A. Delsemme, J. -C. Pecker et H. Reeves
Manfroid, Jean ULg

in Ciel et Terre (1991), 107

Not Available

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See detailVertical Column Abundances and Seasonal Cycle of Acetylene, C2H2, above the Jungfraujoch Station, Derived from IR Solar observations
Zander, Rodolphe ULg; Rinsland, C.P.; Ehhalt, D.H. et al

in Journal of Atmospheric Chemistry (1991), 13

Monthly mean total vertical column abundances of acetylene have been determined from series of infrared solar spectra recorded at the Jungfraujoch station, Switzerland, between June 1986 and April 1991 ... [more ▼]

Monthly mean total vertical column abundances of acetylene have been determined from series of infrared solar spectra recorded at the Jungfraujoch station, Switzerland, between June 1986 and April 1991. The data have been obtained by nonlinear least-squares fittings of the v5 band R19 transition of C2H2 at 776.0818 cm-1. The average of 22 monthly mean total vertical columns of C2H2 retrieved during that time interval of almost 5 years was found to be equal to (1.81 +- O.12) X 1OE15 molec/cm2, which corresponds to an average mixing ratio of (0.22 +- O.013) ppbv (parts per billion by volume) in a troposphere extending from the altitude of the station (3.58 km), up to 10.5 km. Despite the large variability found from year to year, a least-squares sine fit to the data reveals a seasonal variation with an amplitude of about +- 40 % of the mean; the maximum occurs during mid-winter and the minimum in the summer. The present results are compared critically with similar in-situ data found in the literature. A sinusoidal fit to ail such free troposphere measurements made in-situ between 30° N and 60° N indicates good agreement in shape and phase with the seasonal variation derived above the Jungfraujoch, but their average column abundance, 2.3 X lOE15 molec/cm2, is about 30 % higher; this difference is explained on the basis of non-upwelling meteorological conditions generally prevailing during ground-based remote solar observations. [less ▲]

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See detailPollution of P Cygni line profiles by Fe IV and Fe V photospheric absorption in the ultraviolet spectrum of O-type stars
Nemry, F.; Surdej, Jean ULg; Hernaiz, A.

in Astronomy and Astrophysics (1991), 247

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of ... [more ▼]

It is reported that the main pollution in the spectral ranges 1270-1500 and 1500-1860 A is caused by photospheric absorption lines of FeV and FeIV, respectively. Making use of the first order moment W1 of a P Cygni line profile, it is shown that the effect of this photospheric pollution may lead to systematic errors, exceeding typically 50 percent in the determination of mass loss rates. It is also emphasized that the importance to correct the observed P Cygni line profiles for this pollution when studying the dependence of the physical parameters, terminal velocity, etc. of the stellar winds upon the various classes and types of O stars. [less ▲]

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See detailWirksamkeit eines oralen Beruhigungsmittels auf das Verhalten und die zootechnischen Leistungen von Mastbullen der Wei-Blauen Belgischen Rasse
Genicot, Bruno; Mouligneau, Frédéric; Lekeux, Pierre ULg

in Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine (1991), 38

This trial was conducted with 22 Belgian White and Blue double-muscled cattle (body weight: 241.5 +/- 6.2 kg; age: 7 months). Two similar groups were constituted: a group of bulls which were treated with ... [more ▼]

This trial was conducted with 22 Belgian White and Blue double-muscled cattle (body weight: 241.5 +/- 6.2 kg; age: 7 months). Two similar groups were constituted: a group of bulls which were treated with potassium bromide (BT; n = 11) and another one which remained untreated UT; n = 11). The treatment (736 mg potassium bromide/kg feed dry matter) was stopped 60 days before the slaughtering day. The treatment with potassium bromide induced a significantreduction in the rear engagements during the whole trial period (221 days), in direct attacks during the period A (from day 0 to day 53) and in side-on attacks during the period B from day 54 to day 167). The daily weight gains, calculated for the whole trial period, were not significantly different between the two groups. Feed utilization was lower in treated bulls. During the period C (from day 168 to day 221), the sedative potency of potassium bromide seemed to be weaker than during the periods A and B. This might be due to the habituation to potassium bromide. On the basis of these results, we can conclude that the frequency of rear engagements and, during a restricted period of fattening, the frequencies of side and directattacks are significantly reduced when potassium bromide (736 mg/kg feed dry matter) is used. The time spent for hay intake, the frequency of water intake (even if the time consumed at the drinking trough was the same) was reduced and the time during which the bulls were standing was prolonged by bromide [less ▲]

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See detailSpectroscopic investigation of structure in octarellin (a de novo protein designed to adopt the alpha/beta-barrel packing)
Beauregard, Marc; Goraj, Karine; Goffin, Vincent et al

in Protein Engineering (1991), 4(7), 745-9

We present here a spectroscopic structural characterization of octarellin, a recently reported de novo protein modelled on alpha/beta-barrel proteins [K. Goraj, A. Renard and J.A. Martial (1990) Protein ... [more ▼]

We present here a spectroscopic structural characterization of octarellin, a recently reported de novo protein modelled on alpha/beta-barrel proteins [K. Goraj, A. Renard and J.A. Martial (1990) Protein Engng, 3, 259-266]. Infrared and Raman spectra analyses of octarellin's secondary structure reveal the expected percentage of alpha-helices (30%) and a higher beta-sheet content (40%) than predicted from the design. When the Raman spectra obtained with octarellin and native triosephosphate isomerase (a natural alpha/beta-barrel) are compared, similar percentages of secondary structures are found. Thermal denaturation of octarellin monitored by CD confirms that its secondary structures are quite stable, whereas its native-like tertiary fold is not. Tyrosine residues, predicted to be partially hidden from solvent, are actually exposed as revealed by Raman and UV absorption spectra. We conclude that the attempted alpha/beta-barrel conformation in octarellin may be loosely packed. The criteria used to design octarellin are discussed and improvements suggested. [less ▲]

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See detailModèles mathématiques en hydrogéologie et paramétrisation
Dassargues, Alain ULg

in Annales de la Société Géologique de Belgique (1991), 113(2), 217-229

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See detailThree-dimensional electron microscopy of ribosomal chromatin in two higher plants: a cytochemical, immunocytochemical, and in situ hybridization approach.
Motte, Patrick ULg; Loppes, Roland ULg; Menager, M. et al

in Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society (1991), 39(11), 1495-506

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the ... [more ▼]

We report the 3-D arrangement of DNA within the nucleolar subcomponents from two evolutionary distant higher plants, Zea mays and Sinapis alba. These species are particularly convenient to study the spatial organization of plant intranucleolar DNA, since their nucleoli have been previously reconstructed in 3-D from serial ultra-thin sections. We used the osmium ammine-B complex (a specific DNA stain) on thick sections of Lowicryl-embedded root fragments. Immunocytochemical techniques using anti-DNA antibodies and rDNA/rDNA in situ hybridization were also applied on ultra-thin sections. We showed on tilted images that the OA-B stains DNA throughout the whole thickness of the section. In addition, very low quantities of cytoplasmic DNA were stained by this complex, which is now the best DNA stain used in electron microscopy. Within the nucleoli the DNA was localized in the fibrillar centers, where large clumps of dense chromatin were also visible. In the two plant species intranucleolar chromatin forms a complex network with strands partially linked to chromosomal nucleolar-organizing regions identified by in situ hybridization. This study describes for the first time the spatial arrangement of the intranucleolar chromatin in nucleoli of higher plants using high-resolution techniques. [less ▲]

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See detailL'intérêt porté par les poètes et les traducteurs russes à l'Ode III, 30 d'Horace (Exegi monumentum)
Mouton, Charles ULg

in Latomus : Revue d'Etudes Latines (1991), L(3), 654-670

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See detailEntre Meuse, Rhin et Moselle. Aux origines du culte de saint Mengold de Huy
George, Philippe ULg

in Publications de la Section Historique de l'Institut Royal Grand-Ducal de Luxembourg (1991)

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See detailA Note On The Comparison Of Methods For Estimating The Ileal Digestibility Of Amino-Acids In Pigs
Leterme, Pascal; Pirard, L.; Thewis, André ULg

in Animal Production (1991), 52(1), 404-406

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See detailRefinement of the media composition for the in vitro culture of early heart-shaped embryos in Phaseolus vulgaris.
Schmit, V.; Baudoin, Jean-Pierre ULg; Mergeai, Guy ULg

in Annual report of the Bean Improvement Cooperative (1991), 34

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See detailSurgical Management of Left Atrial Myxoma
RADERMECKER, Marc ULg; LAVIGNE, Jean-Paul ULg; Defraigne, Jean-Olivier ULg et al

in Acta Chirurgica Belgica (1991), 91(1), 27-31

Although rare, left atrial myxoma is an entity from anatomopathological and clinical aspects. Seven cases of left atrial myxoma operated on the last ten years were reviewed. We also report a rare ... [more ▼]

Although rare, left atrial myxoma is an entity from anatomopathological and clinical aspects. Seven cases of left atrial myxoma operated on the last ten years were reviewed. We also report a rare presentation of right atrial myxoma, where the tumor was responsible of a dramatic hemodynamic shock due to right ventricular inflow obstruction. Six patients were female, with a mean age of 53 years. All but one consulted for exertional dyspnea of recent onset. Two patients with left atrial myxoma and the patient with right atrial myxoma had experienced embolism. Five patients had systemic symptoms. Echocardiography was the most performant diagnostic procedure. All but the patient with right atrial myxoma were operated by the left atrial access. The mitral valve was replaced in two patients. The histological aspect of this benign tumor is illustrated but the lack of frank border between the tumor and the myocardium is emphasized. We conclude that surgical management is primordial. We give anatomopathological rationale for resection of implantation pedicle. The operative mortality was nul in this series of 8 patients; major improvement of cardiac status was constant. No recurrence has occurred during the follow-up period. [less ▲]

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See detailMolecular size and symmetry of Pseudomonas aeruginosa catabolic ornithine carbamoyltransferase. An X-ray crystallography analysis.
Marcq, S.; Diaz-Ruano, A.; Charlier, Paulette ULg et al

in Journal of Molecular Biology (1991), 220(1), 9-12

The catabolic ornithine carbamoyltransferase (EC 2.1.3.3) from Pseudomonas aeruginosa, that shows allosteric behaviour, and a mutant version of this enzyme has been crystallized in several different ... [more ▼]

The catabolic ornithine carbamoyltransferase (EC 2.1.3.3) from Pseudomonas aeruginosa, that shows allosteric behaviour, and a mutant version of this enzyme has been crystallized in several different crystal forms. All of these have been characterized by X-ray diffraction methods. A 4.5 A resolution data set has been collected on a triclinic crystal. Analysis of the data using the self-rotation function shows that 12 monomers associate to form a particle with cubic 23 point group symmetry. [less ▲]

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See detailThe high affinity murine laminin receptor is a member of a multicopy gene family.
Fernandez, M. T.; Castronovo, Vincenzo ULg; Rao, C. N. et al

in Biochemical and Biophysical Research Communications (1991), 175(1), 84-90

The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid ... [more ▼]

The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid cells as well as in cell lines derived from cancer cells. We have analyzed three distinct cDNA clones isolated from an Okayama-Berg cDNA library of transformed mouse fibroblasts that may represent transcripts of three different laminin receptor genes. Polymorphic changes include insertion of bases at the 5' terminus, a base substitution within the coding region resulting in an amino acid change from phenylalanine to leucine, a base substitution obliterating a polyadenylation signal, as well as changes in the length of the 3' untranslated domains. The discovery of multiple transcripts of laminin receptor genes suggests that there is a strong selective pressure to maintain laminin receptor expression in murine cells. [less ▲]

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See detailEvolution des pressions en oxygène et en dioxyde de carbone et du pH du sang artériel pendant la croissance
Bakima, M.; Lomba, F.; Lekeux, Pierre ULg

in Annales de Médecine Vétérinaire (1991), 135

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