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See detailIsokinetic assessment of the forearm and wrist muscles
Forthomme, Bénédicte ULg; Croisier, Jean-Louis ULg; Foidart-Dessalle, Marguerite ULg et al

in Isokinetics & Exercise Science (2002), 10(3), 121-128

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See detailThe novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener
Dabrowski, M.; Ashcroft, F. M.; Ashfield, R. et al

in Diabetes (2002), 51

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See detailEcueils et chausse-trapes.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 249

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See detailEnquête sur les "contes" de Voltaire
Tilkin, Françoise ULg

in Cahiers Voltaire : Revue Annuelle de la Société Voltaire (2002), 1

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See detailLes acquis des jeunes de 15 ans en sciences : des progrès restent à faire...
Lafontaine, Dominique ULg; Burton, Réginald

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 9-10

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See detailKinetic study of the acid hydrolysis of various oligofructose samples
Blecker, Christophe ULg; Fougnies, C.; Van Herck, J. C. et al

in Journal of Agricultural and Food Chemistry (2002), 50(6), 1602-1607

The kinetic of acid hydrolysis of five commercially available oligofructose samples used as food ingredients has been investigated as a function of the dry matter concentration, reaction pH, and ... [more ▼]

The kinetic of acid hydrolysis of five commercially available oligofructose samples used as food ingredients has been investigated as a function of the dry matter concentration, reaction pH, and temperature. The initial fructose release rate is found to be roughly proportional to the inverse of the average polymerization degree in number. A pseudo first order kinetic is found with respect to the fructosyl chain end concentration and to the proton concentration. Arrhenius plot is found to reasonably fit the data in a relatively wide temperature range (7-130 degreesC). The results allow the estimation of the fructose release rate in many foodstuff processing conditions. [less ▲]

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See detailLe miracle 'flamand' n'est pas prêt-à-porter…
Lafontaine, Dominique ULg

in Cahiers du Service de Pédagogie Expérimentale (SPE) (2002), 9-10

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See detailReconstruction of healthcare in Afghanistan.
Porignon, Denis ULg; Hennart, Philippe

in Lancet (2002), 359(9311), 1071-2

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See detailMemory kernels and effective Hamiltonians from time dependent methods. II. Vibrational predissociation
Brems, Vincent; Desouter, Michèle ULg

in Journal of Chemical Physics (2002), 116

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See detailLe medicament du mois. La rosiglitazone (Avandia).
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(4), 236-9

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma ... [more ▼]

Rosiglitazone (Avandia, Glaxo-SmithKline) belongs to a new family of oral hypoglycaemic agents, thiazolidinediones or glitazones. These molecules act as selective agonists of nuclear receptors (PPAR gamma) and improve insulin sensitivity. In Belgium as in all European countries, rosiglitazone is indicated for the treatment of type 2 diabetes, only in combination with another antidiabetic oral agent, in patients insufficiently controlled with metformin or a sulphonylurea at a maximal tolerated dose. In these patients, rosiglitazone, at a daily dose of 4 mg (sometimes 8 mg/day with metformin), reduces fasting glycaemia by 2-3 mmol/l and glycated haemoglobin level by about 1%. It exerts also favourable effects on some risk factors related to insulin resistance syndrome, which may contribute to improve cardiovascular prognosis of patients with type 2 diabetes. Hepatic safety of rosiglitazone seems to be good, although it is still recommended to check liver enzymes regularly. As all glitazones, rosiglitazone moderately promotes weight gain. It can also induce some fluid retention which may reveal or aggravate heart failure in at risk patients. [less ▲]

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See detailMass transfer by free and forced convection from single spherical liquid drops
Waheed, M Adekojo; Henschke, Martin; Pfennig, Andreas ULg

in International Journal of Heat & Mass Transfer (2002), 45(22), 4507-4514

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See detailL'etude clinique du mois. La MRC/BHF Heart Protection Study.
Kulbertus, Henri ULg; Scheen, André ULg

in Revue Médicale de Liège (2002), 57(9), 613-6

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily ... [more ▼]

20,536 adults (15,454 men and 5,082 women, aged 40-80 years) with coronary heart disease, other occlusive arterial disease or diabetes mellitus were randomly allocated to receive 40 mg simvastatin daily or matching placebo. In addition to being randomized to compare simvastatin vs placebo, all patients were also randomized to compare antioxidant vitamin supplementation (vitamin E 600 mg/day, vitamin C 250 mg/day and betacarotene 20 mg/day) vs placebo in a "2 x 2 factorial" design. Duration of the study was 5 years. All-cause mortality was significantly reduced among patients allocated to simvastatin (-12.3%) due to a highly significant (-18%) reduction in the coronary death rate, a marginally significant reduction in other vascular deaths and a non-significant reduction in non-vascular deaths. There were highly significant reductions (of about one-quarter) in the first event rate for non-fatal myocardial infarction and coronary death (combined), for non-fatal and fatal stroke and for coronary or non-coronary revascularization. The beneficial effect of simvastatin was seen in all sub-categories which were studied and, particularly: women vs men; patients aged > 70 years vs those aged < 70 years; patients with LDL cholesterol < vs > 116 mg/dl, or total cholesterol < vs > 193 mg/dl. The treatment was well tolerated and the annual risk of myopathy was 0.01%. All comparisons between antioxidant vitamin supplementation and placebo failed to reveal any difference in favour or against the supplementation which was otherwise well tolerated. These important results and their implications will be briefly discussed. [less ▲]

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See detailL'iconographie du meurtre de saint Lambert de Liège
George, Philippe ULg

in Bulletin de la Société Royale Le Vieux-Liège (2002)

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See detailCommunication et langage chez les animaux.
Poncin, Pascal ULg; Huynen, Marie-Claude ULg; Ruwet, J.Cl.

in Bulletin de la Société Royale des Sciences de Liège (2002), 4

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See detailPieges et conseils a propos de l'utilisation des antidiabetiques oraux conventionnels.
Scheen, André ULg

in Revue Médicale de Liège (2002), 57(5), 352-6

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of ... [more ▼]

The main pitfalls regarding the use of sulphonylureas and metformin in type 2 diabetic patients are described and illustrated by a clinical case. Advices are given in order to avoid the occurrence of severe hypoglycaemic episodes with sulphonylureas and to minimise the risk of lactic acidosis with metformin. These drugs, when used appropriately with respect of contra-indications, have an excellent safety profile and remain the basis of the treatment of type 2 diabetes. [less ▲]

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See detailChoisir un scénario sylvicole pour les mélèzes
Pauwels, D.; Lejeune, Philippe ULg; Rondeux, Jacques ULg

in Forêt Wallonne (2002), (61), 17-24

Le choix du traitement sylvicole à appliquer à un peuplement forestier est une démarche qui peut s’avérer très complexe si l’on tient compte des délais entre la plantation et la récolte du peuplement ... [more ▼]

Le choix du traitement sylvicole à appliquer à un peuplement forestier est une démarche qui peut s’avérer très complexe si l’on tient compte des délais entre la plantation et la récolte du peuplement final, de l’évolution des filières de transformation, ou encore de la multiplicité des objectifs que peut poursuivre le gestionnaire forestier. [less ▲]

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See detailIncreased binding and defective migration across fibronectin of cycling hematopoietic progenitor cells.
Giet, Olivier ULg; Van Bockstaele, Dirk R; Di Stefano, Ivano et al

in Blood (2002), 99(6), 2023-31

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood ... [more ▼]

Engraftment of hematopoietic progenitor cells has been shown to decrease during cell cycle transit. We studied cell cycle-associated changes in adhesion and migration of mitotically activated cord blood CD34+ cells. Migration toward medium conditioned by the stromal-derived factor-1-producing cell line MS-5 was studied in bovine serum albumin- and fibronectin (Fn)-coated transwells. Migration was reduced in cycling CD34+ cells and long-term culture-initiating cells (LTC-ICs) compared with their noncycling counterparts across Fn but not across bovine serum albumin. Conversely, Fn binding was higher in cycling CD34+ cells and LTC-ICs compared with noncycling progenitor cells, while adhesion of both subsets to bovine serum albumin was undetectable. The contribution of alpha4 and alpha5 integrins in mediating adhesion and migration of activated CD34+ cells onto Fn was analyzed by neutralization experiments. While alpha4-mediated Fn binding decreased during G(2)/M, alpha5 integrin-mediated adhesion increased during transit from G(0)/G(1) to S and G(2)/M phases. As for migration, the contribution of alpha4 integrin was similar in all phases, whereas alpha5-directed migration was lower in G(2)/M compared with G(0)/G(1) and S phases. Defective migration of cycling CD34+ cells was not due to differences in alpha5 integrin expression. In conclusion, chemotaxis across Fn is less efficient in cycling progenitor cells in correlation with an increased Fn binding capacity. In addition, alpha4 and alpha5 integrin functions are independently modulated during cell cycle transit. [less ▲]

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See detailEtude de la perturbation de l'image du corps dans un échantillon de patientes boulimiques
Bragard, Isabelle ULg; Etienne, Anne-Marie ULg; Mayers, I. et al

in Revue Francophone de Clinique Comportementale et Cognitive (2002), 7(2), 5-18

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See detailLes bancs solaires au banc des accusés.
Uhoda, I.; Petite, Louicette ULg; Pierard, Claudine ULg et al

in Revue Médicale de Liège (2002), 57(1), 29-32

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many ... [more ▼]

Sunbeds used in sun parlours do not garantee a controlled innocuity. By contrast, health hazards are obvious in many instances. Forceful tanning is a transitory aspect behind which the spectrum of many skin changes includes accelerated photoageing, irreversible pigmentary and keratotic changes, and cutaneous malignancies including malignant melanoma. In the absence of protection, the eye is also affected. Even if tanning salon exposure increases the risk for skin cancer by a small amount, it represents a significant potential public health hazard given the number of people attending salons. Digital dermoscopy and ultraviolet light videoscopy are new methods allowing to predict the cutaneous ransom to be paid by the sunbed worshippers. [less ▲]

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See detailL'hyperglycemie post-prandiale. I. Physiopathologie, consequences cliniques et approaches dietetiques.
Scheen, André ULg; Paquot, Nicolas ULg; Jandrain, Bernard ULg et al

in Revue Médicale de Liège (2002), 57(3), 138-41

Postprandial hyperglycaemia depends on the amount and type of ingested carbohydrates and/or the degree of inhibition of hepatic glucose output following a meal. The kinetics of carbohydrate absorption is ... [more ▼]

Postprandial hyperglycaemia depends on the amount and type of ingested carbohydrates and/or the degree of inhibition of hepatic glucose output following a meal. The kinetics of carbohydrate absorption is directly influenced by the type of food (carbohydrates with variable glycaemic indices, fibre content of the meal) and by the speed of gastric emptying. Hepatic glucose output is remarkably inhibited by insulin and strongly stimulated by glucagon. It remains abnormally high after a meal in diabetic patients because of insufficient portal insulin concentrations, hepatic insulin resistance and/or hyperglucagonaemia. In diabetic patients, postprandial hyperglycaemia contributes to the aggravation of chronic hyperglycaemia, and thus to the increase of glycated haemoglobin levels. Furthermore, it has been recently demonstrated that postprandial hyperglycaemia increases the cardiovascular risk, even in nondiabetic subjects, probably by inducing endothelial dysfunction. Appropriate dietary counselling plays a key-role in the control of postprandial hyperglycaemia. Generally speaking, it includes a selection of carbohydrates with low glycaemic index and a higher fibre intake. Pharmacological interventions may also be considered when necessary. [less ▲]

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See detailNew silica based polymeric systems designed for the solid-liquid extraction of uranyl ions
Caprasse, F.; Leroy, Delphine ULg; Martinot, Lucien et al

in Journal of Materials Chemistry (2002), 12(1), 137-142

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See detailSelf-esteem, social adjustment and suicidality in affective disorders
Daskalopoulou, E; Dikeos, D; Papadimitriou, G et al

in European Psychiatry (2002), 17

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See detailModelling of an accelerometer based on a levitated proof mass
Houlihan, Ruth; Kraft, Michael ULg

in Journal of Micromechanics and Microengineering (2002), 12(4), 495--503

A triaxial accelerometer is presented which employs as its proof mass a mechanically free micromachined disc that is electrostatically levitated. Air damping plays a critical role in the operation of the ... [more ▼]

A triaxial accelerometer is presented which employs as its proof mass a mechanically free micromachined disc that is electrostatically levitated. Air damping plays a critical role in the operation of the accelerometer, providing stability to an inherently unstable system. Systems that operate beyond the cut-off frequency, however, suffer reduced gain due to the spring component of the squeeze film damping, resulting in decreased sensitivity. A finite-element model for extracting squeeze film damping coefficients for transverse and rotational motion of the disc, via an analogy to heat transfer theory, is presented. The use of the analogy enables a reduction of the problem from a complex three-dimensional computational fluid dynamics domain to a two-dimensional heat transfer domain. The model is used to evaluate the effect of including damping holes in the proof mass. The high-frequency oscillation and physical size of the proof mass dictate that the accelerometer is operated well beyond its cut-off frequency and so the inclusion of damping holes in the proof mass can result in an increase rather than decrease in the damping coefficient. The resulting system-level model, implemented in Matlab/Simulink, is then used to evaluate the effect of the squeeze film damping on the device performance. [less ▲]

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See detailIR-visible sum-frequency vibrational spectroscopy of Biphenyl-3 methylene thiol monolayer on gold and silver: effect of the visible wavelength on the SFG spectrum
Humbert, Christophe; Dreesen, Laurent ULg; Mani, A. A. et al

in Surface Science (2002), 502-503

We measured IR-visible sum-frequency generation spectra of CH3-(C6H4)2-(CH2)3-S-H (Biphenyl-3) self-assembled monolayers on a silver and a gold substrate. For the latter substrate, we observed different ... [more ▼]

We measured IR-visible sum-frequency generation spectra of CH3-(C6H4)2-(CH2)3-S-H (Biphenyl-3) self-assembled monolayers on a silver and a gold substrate. For the latter substrate, we observed different interference patterns between the resonant signal of the CH vibration and the non-resonant contribution of the substrate as a function of the visible beam wavelength. The non-linear response of the gold substrate is enhanced around 480 nm corresponding to the s-d interband transition. Such effect is not observed for the silver substrate the interband transition of which is located out of the investigated visible spectral range of 450-700 nm. [less ▲]

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See detailExamen critique de l'étymologie de brasser
Boutier, Marie-Guy ULg

in Dialectes de Wallonie (2002), 29-30

La filiation traditionnellement établie entre gaulois brace "matière servant à préparer la bière" (dont provient fr. brais) et fr. brasser "préparer la bière" est réexaminée dans cet article par l'examen ... [more ▼]

La filiation traditionnellement établie entre gaulois brace "matière servant à préparer la bière" (dont provient fr. brais) et fr. brasser "préparer la bière" est réexaminée dans cet article par l'examen de l'ensemble du vocabulaire technologique wallon de la brasserie et des réalités concrètes qui sont désignées: la préparation du brais, d'une part; le brassage de la bière, d'autre part. [less ▲]

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See detailComparison of Ricotta cheese made by high pressure treatment with that produced by heat treatment of sweet whey
Besbes, S.; Blecker, Christophe ULg; Attia, H. et al

in Sciences des Aliments (2002), 22(5), 601-615

In this study, reconstituted sweet whey was acidified and then treated by high hydrostatic pressure in order to obtain Ricotta-like product. At pH 5.2, whey protein aggregation was effective beyond 200 ... [more ▼]

In this study, reconstituted sweet whey was acidified and then treated by high hydrostatic pressure in order to obtain Ricotta-like product. At pH 5.2, whey protein aggregation was effective beyond 200 MPa for an application time of 30 min. Moist yield was appreciably improved when pressurisation time increased at 400 MPa. It seemed that granulometric properties of Ricotta-like cheese were not affected by increasing pressurisation time. Ricotta-like products obtained after pressurisation at 400 MPa for 30, 45 and 60 min, have shown a lower yield and hardness but a higher cohesiveness than traditional Ricotta cheese. They also had more homogenous granulometric profiles. [less ▲]

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See detailRole of acetaldehyde in the discriminative stimulus effects of ethanol
Quertemont, Etienne ULg; Grant, Kathleen A

in Alcoholism, Clinical & Experimental Research (2002), 26(6), 812-817

Background: Acetaldehyde has been suggested to mediate some of the effects of ethanol. Acetaldehyde can be produced by the enzyme catalase within the brain after ethanol administration. The catalase ... [more ▼]

Background: Acetaldehyde has been suggested to mediate some of the effects of ethanol. Acetaldehyde can be produced by the enzyme catalase within the brain after ethanol administration. The catalase inhibitor 3-amino-1,2,4-triazole (AT) reduces the production of acetaldehyde, and AT administration can reduce a number of ethanol-induced behavioral effects; this suggests the involvement of acetaldehyde in these behaviors. However, a role for acetaldehyde in mediating the discriminative stimulus effects of ethanol remains unclear. Methods: The contribution of acetaldehyde to the discriminative stimulus effects of ethanol was investigated by use of a two-lever drug discrimination paradigm with food reinforcement. Male Long-Evans rats were trained to discriminate water from either 1.0 or 2.0 g/kg ethanol. Stimulus substitution tests were conducted with ethanol (0 –2.5 g/kg by gavage) and acetaldehyde (0–300 mg/kg intraperitoneally). A cumulative dose-response procedure was then used to investigate the effects of pretreatments with AT (0.5 and 1.0 g/kg intraperitoneally) on ethanol discrimination. Results: Acetaldehyde up to doses that decreased response rates (300 mg/kg) did not substitute for the discriminative stimulus effects of 1.0 or 2.0 g/kg ethanol. In addition, AT pretreatment did not affect the dose-response curves for ethanol discrimination. Conclusions: These results show that exogenous acetaldehyde administration does not produce discriminative stimulus effects that are similar to those of ethanol. Also, pretreatment with the catalase inhibitor did not affect the dose-response curve for ethanol discrimination, and this suggests that endogenously produced acetaldehyde does not contribute to the discriminative stimulus effects of ethanol. Together these results suggest that acetaldehyde does not mediate the discriminative stimulus effects of 1.0 to 2.0 g/kg ethanol. [less ▲]

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See detailCombined implicit-explicit algorithms for non-linear structural dynamics
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Revue Européenne des Éléments Finis (2002), 11(5), 565-591

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact ... [more ▼]

To solve fast dynamic problems, an explicit method is the most adapted. But for slower dynamics, an implicit method is more stable. The industrial problems are governed by high frequency (impact, ...) during short time intervals and slower dynamics (spring-back, ...) during other time intervals. The optimal solution is then to have both implicit algorithm and explicit methods readily available in the same code and to be able to switch automatically from one to another. Criteria that decide when to shift from a method to another have been developed here. Implicit balanced restarting conditions that annihilate numerical oscillations resulting for an explicit calculation are also proposed. [less ▲]

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See detailLlandovery miospore biostratigraphy and stratigraphic evolution of the Parana Basin, Paraguay - Palaeogeographic implications
Steemans, Philippe ULg; Pereira, E.

in Bulletin de la Société Géologique de France (2002), 173(5), 407-414

The Parana Basin covers 1,600,000 km(2) including parts of southern Brazil, Paraguay, Uruguay and Argentina. It contains rocks ranging from the Ordovician to Tertiary in age. The present study is focused ... [more ▼]

The Parana Basin covers 1,600,000 km(2) including parts of southern Brazil, Paraguay, Uruguay and Argentina. It contains rocks ranging from the Ordovician to Tertiary in age. The present study is focused on the Itacurubi Group, of Llandovery age, from Paraguay. The sedimentology and palynology have been studied in three boreholes from the central part of Paraguay. The Itacurubi Group consists of the Euzebio Ayala, Vargas Pena and Cariy Formations. It corresponds to a complete transgressive - regressive cycle with maximum flooding in the Vargas Pena Formation. The sediments of the group were deposited in a glacio-marine regime and are included in the second order sequence. The palynofacies are dominated by acritarchs and chitinozoans, with miospores rare. Among the latter, cryptospores are most abundant and trilete spores very rare. The miospore assemblages are typical of the Llandovery. The presence of Laevolancis divellomedia and the successive first occurrence of the trilete spore genus Ambitisporites, followed by Archaeozonotriletes, allow the recognition of three biozones : divellomedia I, divellomedia II and chulus-nanus. Correlations between the three boreholes based on miospore biostratigraphy and sequence stratigraphy techniques are similar. The miospore assemblages have important palaeogeographic implications: (1) Ordovician / Silurian miospore assemblages, identified in South America are similar to those described in palaeogeographically distinct regions such as China, UK, Belgium, USA etc. This suggests that the phytogeographical differentiation proposed by Gray et al. [1992], with a Malvinokaffric Realm characterised by smooth tetrads and an extra-Malvinokaffric Realm characterised by ornamented tetrads, has to be reconsidered. Clearly, the same miospores are recovered from both regions, no matter if they are close to the palaeo-equator or the palaeo-pole, as is the case in Paraguay. These findings suggest that the same vegetation could survive under various climates. (2) In theory, large oceans could be impassable geographic barriers for land plant miospores larger than 25 mum in diameter. As similar miospore assemblages occur, around the Ordovician - Silurian boundary, on the Gondwana, Avalonia and Laurentia plates, it seems likely that these palaeo-continental plates were in close proximity permitting the expansion of the vegetation through these continents. Therefore, palaeogeographic reconstructions with narrow oceans between the continents better explain early miospore biogeographies in early Silurian times. (3) Maps produced by Dalziel et al. [1994] better explain the diachronism of trilete spore first appearances Hirnantian in Turkey, Rhuddanian in Saudi Arabia, early Aeronian in Libya, late Aeronian in Paraguay, latest Aeronian in UK, and possibly Telychian in USA. (4) The Baltica plate could possibly have been isolated by a geographic barrier during the Ashgill and the Llandovery, as only simple naked tetrads are known from that plate. The first appearance of the trilete spores in Gotland during the early Wenlock could correspond to the end of this geographic isolation. This apparent isolation of the Baltica plate could be due to a lack of data. [less ▲]

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See detailA duality principle for homogeneous vector fields with applications
Moreau, Luc; Aeyels, Dirk; Peuteman, Joan et al

in Systems & Control Letters (2002), 47(1), 37-46

We introduce a duality principle for homogeneous vectorfields. As an application of this duality principle, stability and boundedness results for negative order homogeneous differential equations are ... [more ▼]

We introduce a duality principle for homogeneous vectorfields. As an application of this duality principle, stability and boundedness results for negative order homogeneous differential equations are obtained, starting form known results for positive order homogeneous differential equations. [less ▲]

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See detailRadiative transfer based scaling of LAI/FPAR retrievals from reflectance data of different resolutions.
Tian, Y; Wang, Y; Zhang, Y et al

in Remote Sensing of Environment (2002), 84(1), 143-159

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See detailVers une approche plus efficace du traitement de l'hypertension
Krzesinski, Jean-Marie ULg

in Cardio Spécialistes (2002), 59

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See detailImpact des méthodes d'application sur l'efficacité d'un traitement à base de Pichia anomala souche K contre les maladies de post-récolte des pommes
Jijakli, Haissam ULg; Dickburt, Catherine; Lepoivre, Philippe ULg et al

in VIII journées scientifiquesBiotechnologies végétales: valorisation pour une agriculture durable (2002)

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See detailAndrogenic alopecia and stress-induced premature senescence by cumulative ultraviolet light exposure.
Franchimont, Claudine ULg; Uhoda, I.; Saint Léger, Didier et al

in Exogenous Dermatology : Physical, Chemical, Biological (2002), 1

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair ... [more ▼]

Background : Ultraviolet light radiations (UVR) may be responsible for hair cycle synchronization and telogen effluvium in the animal and humans. The effect if any of cumulative UVR on chronic hair shedding and androgenic alopecia (AGA) is largely unknown. Objective : To compare the severity of AGA with the extent in solar elastosis. Method : The present study combining immunohistochemistry and computerized image analysis was undertaken in 140 men with AGA and 50 non-alopecic men. Solar elastosis was identified using the antibody to lyzozyme, and collagen was revealed by sirius red staining. The number and diameter of hair shafts were also assessed. Results : The scalp dermis was significantly thicker in AGA than in unaffected subjects. The difference was mainly due to a more severe elastosis in baldness. The earliest signs of solar elastosis preceded hair thinning. When elastosis was thicker than 0.2 mm, a negative exponential correlation was found between hair diameter and severity in solar elastosis. Conclusion : Chronic UVR exposure of the scalp may affect the hair cycle and be one exogenous factors influencing negatively the progression of AGA. The induction of stress-induced premature senescence (SIPS) through reactive oxygen species and microinflammation might be operative at the level of the follicular stem cells. [less ▲]

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See detailShunt cardiaque droite-gauche : étiologie possible de migraine avec aura ?
Schoenen, Jean ULg

in Migraine Contact (2002), 2

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See detailIn vitro production of adaline and coccinelline, two defensive alkaloids from ladybird beetles (Coleoptera : Coccinellidae)
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré et al

in Insect Biochemistry and Molecular Biology (2002), 32(9), 1017-1023

In vitro experiments using [1-C-14] and [2-C-14] acetate were devised to study the biosynthesis of the defensive coccinellid alkaloids adaline and coccinelline in Adalia 2-punctata and Coccinella 7 ... [more ▼]

In vitro experiments using [1-C-14] and [2-C-14] acetate were devised to study the biosynthesis of the defensive coccinellid alkaloids adaline and coccinelline in Adalia 2-punctata and Coccinella 7-punctata, respectively. The labelled alkaloids obtained in these experiments had a specific activity about ten times higher than that of the samples obtained in feeding experiments. This in vitro assay has enabled us to demonstrate that these two alkaloids are most likely biosynthesised through a fatty acid rather than a polyketide pathway, that glutamine is the preferred source of the nitrogen atom and that alkaloid biosynthesis takes place in the insect fat body. [less ▲]

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See detailAmélioration des ovins dans l'Ouémé et le Plateau en République du Bénin. Enjeux des croisements des ovins Djallonké avec les moutons du Sahel
Gbangboche, A. B.; Abiola, F. A.; Laporte, J.-P. et al

in Tropicultura (2002), 20(2), 70-75

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See detailDifferential expression of two somatostatin genes during zebrafish embryonic development
Devos, Nathalie; Deflorian, Gianluca; Biemar, Frédéric et al

in Mechanisms of Development (2002), 115(1-2), 133-7

We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with ... [more ▼]

We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999). PPSS1 is the orthologue of mammalian PPSSs, with a conserved C-terminal SS-14 sequence, PPSS2 is a divergent SS precursor and PPSS3 is a cortistatin-like prohormone. Using whole-mount in situ hybridisation, we have analysed the expression of PPSS1 and PPSS2 in zebrafish embryos up to 5 days post fertilisation. PPSS1 was expressed in the developing pancreas and central nervous system (CNS), whereas PPSS2 expression was exclusively pancreatic. In the CNS, PPSS1 was detected in several areas, in particular in the vagal motor nucleus and in cells that pioneer the tract of the postoptic commissure. PPSS1 was also expressed transiently in the telencephalon and spinal motor neurons. In all areas but the telencephalon PPSS1 was coexpressed with islet-1. [less ▲]

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See detailCollision-induced dissociation of 16-mer DNA duplexes with various sequences: evidence for conservation of the double helix conformation in the gas phase
Gabelica, Valérie ULg; De Pauw, Edwin ULg

in International Journal of Mass Spectrometry (2002), 219(1), 151-159

The MS/MS of 11 different 16-mer non-self-complementary DNA duplexes with various sequences has been under-taken with a quadrupole-TOF hybrid instrument, The comparison of the dissociation yields for ... [more ▼]

The MS/MS of 11 different 16-mer non-self-complementary DNA duplexes with various sequences has been under-taken with a quadrupole-TOF hybrid instrument, The comparison of the dissociation yields for complexes having different amounts of GC base pairs, though complicated by side-reactions like single-strand fragmentation, confirms the effect of the number of GC base pairs. More importantly, for complexes containing the same fraction of GC and different base sequences, the fragmentation yield remarkably parallels the DeltaH(diss) in solution calculated by a nearest-neighbor model for B-DNA. In addition to specific hydrogen bonding interactions, base stacking interactions also seem to survive in the gas phase and the conformation is conserved in the gas phase. Moreover, we have studied the uneven partition of the negative charges between the single strands, which was found to be directed by the nature of the terminal bases exclusively, and correlated with the gas-phase acidities of the (sugar-phosphate-sugar-base) species. [less ▲]

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See detailSynthesis and ring-opening metathesis polymerization of eight-membered unsaturated lactams and related monomers
Baran, Janusz; Bogdanska, Irena; Jan, Dominique et al

in Journal of Molecular Catalysis A-Chemical (2002), 190(1-févr Sp. Iss. SI), 109-116

Novel eight-membered ring unsaturated lactams were synthesized and tested as monomers for the ruthenium-catalyzed ring-opening metathesis polymerization (ROMP). The reaction of a N-protected cyclic ... [more ▼]

Novel eight-membered ring unsaturated lactams were synthesized and tested as monomers for the ruthenium-catalyzed ring-opening metathesis polymerization (ROMP). The reaction of a N-protected cyclic alkeneamine was also investigated. The Grubbs' benzylidene complexes RuCl2(=CHPh)(PCy3)(2) or RUCl2(=CHPh)(PCy3)(IMesH(2)) and selected ruthenium-arene species bearing either phosphine or stable Arduengo-type N-heterocyclic carbene ligands served as catalyst precursors. In most cases, isomerization of the starting materials took place and only 1-benzyl-1-aza-2-ketocyclooct-5-ene afforded a polymeric product. This polyamide was characterized by numerous analytical techniques. (C) 2002 Elsevier Science B.V All rights reserved. [less ▲]

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See detailRadiation-associated synovial-sarcoma: clinicopathological and molecular analysis of two cases.
Egger, J-F; Coindre, J-M; Benhattar, J et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2002), 15(9), 998-1004

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant ... [more ▼]

Development of a soft-tissue sarcoma is an infrequent but well-known long-term complication of radiotherapy. Malignant fibrous histiocytomas, extraskeletal osteosarcomas, fibrosarcomas, malignant peripheral nerve sheath tumors, and angiosarcomas are most frequently encountered. Radiationassociated synovial sarcomas are exceptional. We report the clinicopathologic, immunohistochemical, and molecular features of two radiationassociated synovial sarcomas. One tumor developed in a 42-year-old female 17 years after external irradiation was given for breast carcinoma; the other occurred in a 34-year-old female who was irradiated at the age of 7 years for a nonneoplastic condition of the left hand. Both lesions showed morphologic features of monophasic spindle cell synovial sarcoma, were immunoreactive for cytokeratins, epithelial membrane antigen, CD99, CD117 (c-kit), and bcl-2 and bore the t(X;18) (SYT-SSX1) translocation. We conclude that synovial sarcoma has to be added to the list of radiation-associated soft-tissue sarcomas. Mod Pathol 2002;15(9):998–1004 [less ▲]

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See detailStructural determinants of cold adaptation and stability in a psychrophilic alpha-amylase
D'Amico, Salvino ULg; Gerday, Charles ULg; Feller, Georges ULg

in Biologia (2002), 57(Suppl. 11), 213-219

The heat-labile alpha-amylase from an Antarctic bacterium is the largest known protein that unfolds reversibly according to a two-state transition, as shown by differential scanning calorimetry. Mutants ... [more ▼]

The heat-labile alpha-amylase from an Antarctic bacterium is the largest known protein that unfolds reversibly according to a two-state transition, as shown by differential scanning calorimetry. Mutants of this enzyme were produced, carrying intended additional weak interactions of a type found in thermostable alpha-amylases. It is shown that single amino acid side chain substitutions can significantly modify the melting point T-m, the calorimetric enthalpy DeltaH(cal), the cooperativity and reversibility of unfolding, the thermal inactivation rate constant, and the kinetic parameters k(cat) and K-m. Although all mutations were located far from the active site, their overall trend is to decrease both k(cat) and K-m, probably by making the molecule more rigid, but this protects mutants against thermal inactivation. [less ▲]

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See detailEssais et modélisations d'assemblages soudés entre tubes elliptiques
Bortolotti, E.; Jaspart, Jean-Pierre ULg; Pietrapertosa, C. et al

in Revue de Métallurgie [=Revue de Métallurgie. Cahiers d'Informations Techniques] (2002)

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See detailUlcère veineux chronique et colonisation bactérienne critique. Quand antiseptique rime avec cytotoxicité bénéfique.
Henry, Frédérique ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Angeiologie (2002), 54

The pathogenesis of venous ulcers is complex. A critical bacterial colonization may play a harmfull role. The use of topical antibiotics is unwise, and that of antiseptics is still a matter of debate ... [more ▼]

The pathogenesis of venous ulcers is complex. A critical bacterial colonization may play a harmfull role. The use of topical antibiotics is unwise, and that of antiseptics is still a matter of debate. Some authors contend that antiseptics mitigate wound healing through a toxic effect upon keratinocytes and fibroblasts. However, sound arguments support the paradoxical concept of beneficial cytotoxicity of antiseptics in the treatment of chronic venous ulcers. [less ▲]

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See detailAphid prey suitability as environmental effect on Adalia bipunctata reproduction.
Vanhaelen, Nicolas; Gaspar, Charles ULg; Francis, Frédéric ULg

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 563-8

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding ... [more ▼]

Secondary plant metabolites (allelochemicals) play a major role in plant-insect interactions. Glucosinolates (GLS) and their degradation products from Brassica species are attractants and feeding stimulants for Brassicaceae specialist insects but are generally repellent and toxic for generalist herbivores. The impact of these compounds on crucifer specialist insects are well known but their effect on generalist predators is still not well documented. Prey host plant influence on reproduction of an aphidophagous beneficial, the two spot ladybird, was determined using the cabbage aphid, Brevicoryne brassicae reared on a crucifer plant, namely Brassica napus containing low GLS levels. As ladybird developmental and reproductive parameters were already shown to be strongly affected by the allelochemical presence in its preys, the unsuitable aphid and host plant combination was only momentary used to feed the A. bipunctata adults. A strong impact of the diet was observed on the beetle fecundity and the emerging offspring. Changing B. brassicae aphid to a suitable prey slowly improved the temporary negative effect of the former diet. These results enhance the food environmental effect and the importance of tritrophic relations in pest management strategies by predators. Indeed, more than the choice of the beneficial species, the prey host plant has a major influence on the potential efficacy of biological agent to control herbivore species such as aphids. [less ▲]

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See detailRecension de l'ouvrage collectif, "L'art et l'hybride"
Steinmetz, Rudy ULg

in Cahiers Internationaux de Symbolisme (2002)

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See detailPhylogeny and Morphological Evolution of the Amblystegiaceae (Bryopsida)
Vanderpoorten, Alain ULg; Hedenäs, L.; Cox, C. J. et al

in Molecular Phylogenetics & Evolution (2002), 23

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See detailFécondité de la vache Borgou au Bénin : effet de l'âge au premier vêlage sur l'intervalle entre vêlages
Adamou-N'Diaye, M.; Gbangboche, A. B.; Ogodja, O. J. et al

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (2002), 55(2), 1-5

Des données recueillies à la ferme du monastère de Kokoubou (département du Borgou au Bénin) ont servi à étudier l’âge au premier vêlage et l’intervalle entre vêlages chez la vache Borgou. De 1967 à 1989 ... [more ▼]

Des données recueillies à la ferme du monastère de Kokoubou (département du Borgou au Bénin) ont servi à étudier l’âge au premier vêlage et l’intervalle entre vêlages chez la vache Borgou. De 1967 à 1989, 91 âges au premier vêlage et 524 intervalles entre vêlages ont été utilisés. L’âge moyen au premier vêlage a été de 1 122 ± 257 jours (37,4 ± 7,9 mois, soit 3 ans et 26 jours) et l’intervalle moyen entre vêlages a été de 450 ± 132 jours (14,8 ± 4,4 mois, soit un an et 2,8 mois). L’effet de l’âge au premier vêlage sur l’intervalle entre vêlages a été très significatif (p < 0,001) et faible (r = 0,22). [less ▲]

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See detailPhénomènes karstiques fossiles et actuels au sein des formations métamorphiques silico-alumineuses de la nappe pan-africaine de Yaoundé (Sud-Cameroun)
Vicat, Jean-Paul; Mvondoc, Henri; Willems, Luc ULg et al

in Comptes Rendus de l'Académie des Sciences. Série II, Mécanique, Physique, Chimie, Sciences de l'Univers, Sciences de la Terre (2002), 334

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non ... [more ▼]

Fossil and present-time karstic phenomena in silico-aluminous metamorphic formations of the Pan-African nappe of Yaoundé (South-Cameroon). Numerous karstic features have been recognised in the non-carbonaceous micaschists and gneisses of the Yaoundé Pan-African nappe, south of Cameroon. It is shown that their formation was controlled by the structural features of the rocks. The wells and the pipes in the bedrock outcrops point out a current karstification process, resulting from the plagioclase dissolution by the acid rain waters. Hill wall alveoli and caves, of pre-Miocene age, are exhumed features that were done by dissolution in the aquiferous underground. [less ▲]

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See detailChilocorine D, a novel heptacyclic alkaloid from a coccinellid beetle (Chilocorus renipustulatus)
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré et al

in Tetrahedron Letters (2002), 43(42), 7465-7467

Chilocorine D, a new heptacyclic 'dimeric' alkaloid, has been isolated from the coccinellid beetle Chilocorus renipustulatus and its structure determined by 1D and 2D NMR analyses. It is constituted of a ... [more ▼]

Chilocorine D, a new heptacyclic 'dimeric' alkaloid, has been isolated from the coccinellid beetle Chilocorus renipustulatus and its structure determined by 1D and 2D NMR analyses. It is constituted of a hippodamine moiety linked to a modified octahydro-azaacenaphtylene skeleton encompassing a seven-membered ring. [less ▲]

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See detailTaxonomic assessment, distribution, and ecology of Tortula vahliana var. minor (Pottiaceae, Bryopsida)
Andriessen, L.; Nagels, C.; Arts, T. et al

in Journal of Bryology (2002), 24

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See detailDétermination automatique de la taille du pas de temps pour les schémas implicites en dynamique non-linéaire
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg et al

in Mécanique & Industries (2002), 3(1), 63-77

Pour les problèmes caractérisés par de fortes non-linéarités, ainsi que des phénomènes d'impacts et de contacts, une stratégie d'intégration à pas de temps variables est particulièrement intéressante. Ces ... [more ▼]

Pour les problèmes caractérisés par de fortes non-linéarités, ainsi que des phénomènes d'impacts et de contacts, une stratégie d'intégration à pas de temps variables est particulièrement intéressante. Ces phénomènes sont par exemple rencontrés lors de l'étude dynamique d'une interaction aube-carter d'un moteur d'avion, le cas le plus critique étant la perte de l'aube. Une stratégie d'intégration implicite à pas de temps constant donne rarement satisfaction du fait qu'il est pratiquement impossible de déterminer une durée de pas qui ne conduise pas à la divergence ou à un coût de calcul prohibitif. Une gestion automatique du pas de temps, qui tient compte de l'histoire récente des accélérations dans le corps considéré, est proposée. En fait, l'algorithme est basé sur la mesure de l'erreur d'intégration des équations d'équilibre. Cela permet d'intégrer correctement les phénomènes transitoires avec un pas de temps très long (en régime) ou très petit (lors de la perte d'aube), en garantissant une bonne précision en un temps de calcul raisonnable. De plus, un algorithme qui décide automatiquement de recalculer ou non, la matrice hessienne est proposé. Cet algorithme permet d'éviter un nombre important de remises à jour de cette matrice, ce qui permet de réduire le coût de calcul tout en assurant la convergence. Enfin, un critère de divergence des itérations est proposé. Afin d'illustrer l'efficacité des algorithmes développés, des simulations numériques sont présentées. Il s'agit aussi bien de problèmes académiques que de problèmes industriels (contacts aubes carter). [less ▲]

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See detailAortofemorographie par resonance magnetique nucleaire versus arteriographie conventionnelle: evaluation prospective.
NCHIMI LONGANG, Alain ULg; Brisbois, D.; Donkers, E. et al

in JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR) (2002), 85(5), 246-51

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively ... [more ▼]

PURPOSE: To determine how far MRA of lower limbs obviates the need for pre-therapeutic DSA. MATERIALS AND METHOD: Three-step 3-D gadolinium enhanced aortofemorography with a moving bed was prospectively compared to DSA in 49 consecutive patients (40 males, 9 females; age range 38-80 years; mean age 64 years). According to Leriche and Fontaine's clinical gradation of lower limb ischemia, 5 patients were graded I, 37 graded II, 4 graded III, and 3 graded IV. Two observers graded stenoses for DSA and three for MRA. Cohen's kappa statistics were used to evaluate interobserver variability using MRA, as well as to compare MRA to DSA. In addition, sensitivity, specificity, positive and negative predictive values of MRA for the assessment of stenosis superior to 80% were calculated by using DSA as a gold standard, respectively for arterial trunks above and below the level of the knees. RESULTS: Overall accuracy of MRA was 92%. Comparison of DSA and MRA yielded a kappa value of 0.87 (0.95 for arterial trunks located above the level of the knees and 0.75 below). Interobserver agreement was very good. Sensitivity, specificity, positive and negative predictive values of MRA for the diagnosis of > 80% stenosis were respectively 98, 98, 85 and 99% above the level of the knees and 87, 91, 77 and 96% below the knees. CONCLUSION: MRA can be considered as valuable technique for the evaluation of peripheral arterial obstructive disease, especially for stenosis located above the level of the knees. [less ▲]

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See detailCaractéristiques du système immunitaire du fœtus bovin et du veau nouveau-né. Implications dans la prévention et le diagnostic des infections d’origine virale
Thiry, Etienne ULg; Schynts, F.; Lemaire, Mylène

in Annales de Médecine Vétérinaire (2002), 146(4, AUG-SEP), 225-232

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three ... [more ▼]

In this review the characteristics of the immune system of the bovine fetus and neonate are presented. These characteristics are important for the prevention and diagnosis of viral infections. Three examples are illustrated in this review : direct and indirect consequences of the infection of the fetus by the bovine viral diarrhea virus; guidelines for a prevention and diagnosis of this viral infection are given; the infection of the neonate by rotaviruses where colostral immunity has a key role in the prevention of the disease; the infection of the neonate by bovine herpesvirus 1 in the presence of colostral immunity which does not prevent latency and can lead to seronegative latent carriers after the disappearance of maternal antibodies. [less ▲]

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See detailEffects of peripartum dietary supplements on productive/reproductive parameters in plasma concentration of insulin-like growth factor (IGF)-I in camels.
Hammadi, M.; Khorchani, T.; Moslah, M. et al

in Advances in Reproduction (2002), 6

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See detailBriefe an Goethe. Gesamtausgabe in Regestform. Bd. 6.1 und 6.2 (Rezension)
Viehöver, Vera ULg

in Germanistik (2002), 43(3/4), 5288

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See detailCompte rendu de l'ouvrage de D. Giovannangeli : Le retard de la conscience
Cormann, Grégory ULg

in Revue Internationale de Philosophie (2002), 219(1), 144-149

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See detailColumnar defects acting as passive internal field detectors
Silhanek, Alejandro ULg; Civale, L.; Avila, M. A.

in Physical Review. B : Condensed Matter (2002), 65(17),

We have studied the angular dependence of the irreversible magnetization of several YBa2Cu3O7 and 2H-NbSe2 single crystals with columnar defects tilted off the c axis. At high magnetic fields, the ... [more ▼]

We have studied the angular dependence of the irreversible magnetization of several YBa2Cu3O7 and 2H-NbSe2 single crystals with columnar defects tilted off the c axis. At high magnetic fields, the irreversible magnetization M-i(Theta) exhibits a well-known maximum when the applied field is parallel to the tracks. As the field is decreased below Hsimilar to0.02H(c2), the peak shifts away from the tracks' direction toward either the c axis or the ab planes. We demonstrate that this shift results from the misalignment between the external and internal field directions due to the competition between anisotropy and geometry effects. [less ▲]

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See detailCompte rendu de I. Galster : La naissance du « phénomène Sartre »
Cormann, Grégory ULg

in Revue Philosophique de Louvain (2002), 1-2

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See detailLymecycline and minocycline in inflammatory acne: a randomized, double-blind intent-to-treat study on clinical and in vivo antibacterial efficacy.
Pierard, Claudine ULg; Goffin, Véronique ULg; Arrese Estrada, Jorge ULg et al

in Skin Pharmacology & Applied Skin Physiology (2002), 15(2), 112-9

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and ... [more ▼]

BACKGROUND: Some antibiotics represent a mainstay in acne treatment. However, studies comparing their efficacies are rare. AIM: To evaluate the clinical and in vivo antibacterial effect of lymecycline and minocycline at different dosages. METHOD: Eighty-six patients with moderate to severe acne were enrolled in a randomized, double-blind, intent-to-treat study comparing in three parallel groups the effect of (1) lymecycline 300 mg daily for 12 weeks, (2) minocycline 50 mg daily for 12 weeks and (3) minocycline 100 mg daily for 4 weeks followed by 50 mg daily for 8 weeks. Evaluations were made at the screening visit and at five on-treatment visits. They consisted of clinical counts of acne lesions and evaluations of bacterial viability using dual flow cytometry performed on microorganisms collected from sebaceous infundibula by cyanoacrylate strippings. RESULTS: Patients receiving minocycline 100/50 mg had the best clinical outcome, particularly in the reduction of the number of papules. By the end of the trial, the microbial response to minocycline 100/ 50 mg was also superior to either of the other two treatments. There were less live and more dead bacteria. CONCLUSION: In this trial, minocycline 100/50 mg was superior for the treatment of inflammatory acne when compared to lymecycline 300 mg and minocycline 50 mg. [less ▲]

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See detailDNA immunisation. New histochemical and morphometric data.
Ehirchiou, D.; Zorzi, Willy ULg; Biemans, R. et al

in European Journal of Histochemistry (2002), 46(3), 215-22

Splenic germinal center reactions were measured during primary response to a plasmidic DNA intramuscular injection. Cardiotoxin-pretreated Balb/c mice were immunized with DNA plasmids encodmg or not the ... [more ▼]

Splenic germinal center reactions were measured during primary response to a plasmidic DNA intramuscular injection. Cardiotoxin-pretreated Balb/c mice were immunized with DNA plasmids encodmg or not the SAG1 protein, a membrane antigen of Toxoplasma gondii. Specific anti-SAG1 antibodies were detected on days 16 and 36 after injection of coding plasmids. The results of ELISAs showed that the SAG1-specific antibodies are of the IgG2a class. Morphometric analyses were done on serial immunostained cryosections of spleen and draining or non-draining lymph nodes. This new approach made it possible to evaluate the chronological changes induced by DNA immunisation in the germinal centres (in number and in size). Significant increases in the number of germinal centres were measured in the spleen and only in draining lymph nodes after plasmid injection, the measured changes of the germinal centers appeared to result from the adjuvant stimulatory effect of the plasmidic DNA since both the coding and the noncoding plasmid DNA induced them. No measurable changes were recorded in the T-dependent zone of lymph organs. [less ▲]

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See detailPhytoremediation to increase the degradation of PCBS and PCDD/Fs
Campanella, Bruno ULg; Bock, Claudia; Schröder, Peter

in Environmental Science and Pollution Research (2002), 9

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See detailCaractérisation physico-chimique de gommes végétales exsudées par quelques acacias du Burkina Faso
Djiré, O.; Ntema, P.; Zgoulli, S. et al

in Science et Technique (2002), 25(2), 37-47

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See detailEuclidean and fractal computer-assisted corneofungimetry: a comparison of 2% ketoconazole and 1% terbinafine topical formulations.
Arrese Estrada, Jorge ULg; Fogouang, L.; Pierard, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(3), 222-7

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups ... [more ▼]

BACKGROUND: The corneofungimetry bioassay was designed as a unique model predicting the efficacy of topical and oral antifungals in dermatomycoses. OBJECTIVE: In this 2-step study performed in two groups of 15 volunteers, corneofungimetry was used to compare the effect of 5-day b.i.d. treatments with 2% ketoconazole and 1% terbinafine creams. METHODS: The bioassay was performed using 10 isolates of each of the 3 fungi Trichophyton rubrum, T. mentagrophytes var. interdigitale and Candida albicans put to grow on human stratum corneum. Controls were stratum corneum either untreated or enriched in propylene glycol contained in an unmedicated vehicle. Quantitative assessments were made using both Euclidean and fractal geometry parameters. RESULTS: In comparison with untreated stratum corneum, the fungitoxic activity of the 2% ketoconazole and 1% terbinafine formulations was obvious and similar against dermatophytes. By contrast, 2% ketoconazole was significantly more active against C. albicans than 1% terbinafine. The propylene-glycol-containing vehicle did not exhibit a significant effect upon the dermatophyte growth. Positive linear correlations were yielded between the extent area and the fractal dimension D of dermatophyte mycelia. By contrast, D appeared unrelated to the relative area of dermatophyte growth compared to controls. CONCLUSION: The combination of Euclidean and fractal analyses improves the information provided by the corneofungimetry bioassay. Creams containing 2% ketoconazole and 1% terbinafine appear equally effective against dermatophytes while the former is more potent against Candida albicans. [less ▲]

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See detailChanging pattern of bacterial susceptibility to antibiotics in hematopoietic stem cell transplant recipients.
Frere, Pascale ULg; Hermanne, J.-P.; Debouge, M.-H. et al

in Bone Marrow Transplantation (2002), 29(7), 589-94

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to ... [more ▼]

Adequate infection prophylaxis and empirical antibiotic therapy are of critical importance after hematopoietic stem cell transplantation (HSCT). We examined the evolution of bacterial susceptibility to antibiotics in 492 patients (198 allografts and 294 autografts) transplanted between 1982 and 1999 and evaluated whether ciprofloxacin prophylaxis and an empirical antibiotic regimen (glycopeptide + third-generation cephalosporin) were still valid. We collected all susceptibility tests performed during the initial hospitalization on blood cultures as well as routine surveillance cultures and analyzed susceptibility to ciprofloxacin and to major antibiotics used in our unit. Gram-positive cocci rapidly became resistant to ciprofloxacin (susceptibility around 70% in 1990 to less than 20% in 1998) but sensitivity to glycopeptides remained unaltered. There was a rapid decline in the number of patients colonized with Gram-negative bacilli in the early years of ciprofloxacin prophylaxis. However, susceptibility to ciprofloxacin fell sharply from around 90% in 1990 to around 30% in 1999. In parallel, susceptibility to ceftazidime also decreased to less than 80% in recent years. Piperacillin (+/- tazobactam) did not show any variation over time and its efficacy remained too low (about 60%). Imipenem as well as recently introduced cefepim and meropenem showed stable and excellent profiles (>90% susceptibility). In conclusion: (1) quinolone prophylaxis has now lost most of its value; (2) the choice of a third-generation cephalosporin for empirical antibiotic therapy may no longer be the best because of the emergence of Gram-negative strains resistant to beta-lactamases, such as Enterobacter sp. More appropriate regimens of empirical antibiotic therapy in HSCT recipients may be based on the use of a carbapenem or fourth-generation cephalosporin. [less ▲]

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See detailComment j'explore ... une métastase orpheline d'un mélanome.
Henry, Frédérique ULg; Pierard, Claudine ULg; Arrese Estrada, Jorge ULg et al

in Revue Médicale de Liège (2002), 57(6), 405-7

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then ... [more ▼]

A presumed melanoma metastasis is sometimes found without any evidence for the primary neoplasm. Such an orphan metastasis merits a complementary exploration. Searching for the primary melanoma must then be performed using non invasive and clinically oriented methods. Beside a thorough skin examination, otorhinolaryngological, ophtalmic and gynecologic searches are recommended. In addition, paraclinical investigations are conducted according to the metastatic location, the gender and the functional complaints of the patient. The prognosis of these orphan metastases is not more dramatic than when the primary lesion is identified. Therapies are similar to those proposed in the classical presentation of the disease. [less ▲]

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See detailLe vers semi-libre d'Yves Bonnefoy dans 'Ce qui fut sans lumiere'
Purnelle, Gérald ULg

in Français Moderne (Le) (2002), 70(2), 145-168

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See detailExplorer les secrets du patrimoine cheveux.
Franchimont, Claudine ULg; Pierard, Gérald ULg

in Skin (2002), 5

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See detail2-Alkyl-3-alkylamino-2H-benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
Ouedraogo, R.; Becker, B.; Boverie, S. et al

in Biological Chemistry (2002), 383

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See detailRenouvellement des pédagogies musicales. Analyse et développement des innovations dans les cours d'instruments semi-collectifs
Giot, Bernadette ULg; Grifnée, Catherine

in Site du Ministère de la Communauté française de Belgique (2002)

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See detailAspects de la conclusion du contrat par voie électronique
Biquet, Christine ULg; Decharneux, Joëlle ULg

in Actualités du Droit (2002)

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See detailKeratinocyte injury in drug-induced toxic epidermal necrolysis: Simultaneous but distinct topographic expression of CD95R and calprotectin.
Paquet, Philippe ULg; Pierard, Gérald ULg

in International Journal of Molecular Medicine (2002), 10(2), 145-7

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the ... [more ▼]

Keratinocyte injury in drug-induced toxic epidermal necrolysis (TEN) is attributed to a dysregulation in the complex apoptotic machinery. This study was performed to investigate some aspects of the apoptotic pathomechanism involving calprotectin and the CD95 receptor (CD95R, FasR) in TEN. The expression of these two molecules corresponds to calcium-dependent and calcium-independent processes, respectively. Biopsies were collected from blistering skin in 21 TEN patients and from clinically uninvolved skin in 16 of these patients. Immunohistochemistry was performed using specific antibodies directed to CD95R and calprotectin. Half (8/16) of the biopsy specimens taken from clinically uninvolved sites showed the expression of calprotectin throughout the epidermis or restricted to the suprabasal layers. In these samples, a strong CD95R immunoreactivity was often restricted to the basal layer (8/16). Calprotectin was present in all biopsies of bullous skin, especially in suprabasal layers (15/21) or throughout the epidermis (6/21). By contrast, the prominent expression of CD95R was confined almost exclusively to the basal layer (15/21), and more rarely throughout the epidermis (2/21), and it remained sometimes unexpressed (4/21). A clear-cut boundary was often present between the areas labeled by the two antibodies with exceptional overlap between them. The simultaneous expression of calprotectin and CD95R in TEN at distinct levels of the epidermis indicates that the pathomechanism leading to keratinocyte death does not belong to a single process in TEN. Their expression in clinically uninvolved skin suggests that these processes are early and widespread events in TEN. [less ▲]

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See detailIn vitro and in vivo effects of new insulin releasing agents
Nguyen, Q. A.; Antoine, M. H.; Ouedraogo, R. et al

in Biochemical Pharmacology (2002)

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See detailRefroidissement de +32°C à +5°C du sperme dilué de taureau de race Borgou au Bénin
Adamou-N'Diaye, M.; Gbangboche, A. B.; Adjovi, A. et al

in Annales des Sciences Agronomiques du Bénin (2002), 3(1), 81-93

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See detailStudy of the early abortion in reciprocal crosses between Phaseolus vulgaris L. and Phaseolus polyanthus Greenm
Geerts, P.; Toussaint, André ULg; Mergeai, Guy ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2002), 6(2), 109-119

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See detailThe importance of being small
Tharakan, Joseph ULg; Thisse, Jacques

in Regional Science & Urban Economics (2002), 32

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See detailPre- and post-harvest practical application of Pichia anomala strain K, beta-1,3-glucans and calcium chloride on apples: two years of monitoring and efficacy against post-harvest diseases.
Jijakli, Mohamed ULg; de Clercq, Deborah; Dickburt, Catherine et al

in Bulletin OILB/SROP = IOBC/WPRS Bulletin (2002), 25(10), 29-32

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See detailLa guerre et la médecine d'une culture de paix. 5. Synopsis des armes non létales.
Pierard, Gérald ULg

in Revue Médicale de Liège (2002), 57(3), 176-8

Non lethal weapons may be harmful for people. The effects are accidental in some instances. For some weapons, they are clearly intentional. The eventuality of a fatal issue cannot be ruled out.

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See detailAnalysis Of The C-Terminal Membrane Anchor Domains Of Hepatitis C Virus Glycoproteins E1 And E2: Toward A Topological Model
Charloteaux, Benoît ULg; Lins, Laurence ULg; Moereels, H. et al

in Journal of Virology (2002), 76(4), 1944-58

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen ... [more ▼]

The hepatitis C virus (HCV) glycoproteins E1 and E2 should be anchored in the viral membrane by their C-terminal domains. During synthesis, they are translocated to the endoplasmic reticulum (ER) lumen where they remain. The 31 C-terminal residues of the E1 protein and the 29 C-terminal residues of the E2 protein are implicated in the ER retention. Moreover, the E1 and E2 C termini are implicated in E1-E2 heterodimerization. We studied the E1 and E2 C-terminal sequences of 25 HCV strains in silico using molecular modeling techniques. We conclude that both C-terminal domains should adopt a similar and peculiar configuration: one amphipathic alpha-helix followed by a pair of transmembrane beta-strands. Several three-dimensional (3-D) models were generated. After energy minimization, their ability to interact with membranes was studied using the molecular hydrophobicity potentials calculation and the IMPALA procedure. The latter simulates interactions with a membrane by a Monte Carlo minimization of energy. These methods suggest that the beta-hairpins could anchor the glycoproteins in the ER membrane at least transiently. Anchoring could be stabilized by the adsorption of the nearby amphipathic alpha-helices at the membrane surface. The 3-D models correlate with experimental results which indicate that the E1-E2 transmembrane domains are involved in the heterodimerization and have ER retention properties. [less ▲]

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See detailCharacterisation of aphid myrosinase and degradation studies of glucosinolates
Francis, Frédéric ULg; Lognay, Georges ULg; Wathelet, Jean-Paul ULg et al

in Archives of Insect Biochemistry and Physiology (2002), 50(4), 173-182

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification ... [more ▼]

Myrosinase from Brevicoryne brassicae was purified by ammonium sulfate fractionation, dialysis, and chromatography on a DEAE column. The chromatography yielded a single peak and a 115.6-fold purification. Further FPLC gel filtration gave a single peak at 120 kDa. Denaturing SDS/PAGE of the protein revealed a single band at 60 kDa, indicating that the native B. brassicae myrosinase is a dimer. Kinetic parameters towards 8 glucosinolates were calculated. Strong differences of V-max and Km were observed depending on the substrate. Degradation products of each glucosinolate were identified and quantified by GC-MS and GLC-FID, respectively. Using both crude aphid homogenates and purified myrosinase, two unique hydroxyglucosinolates, 3-butenyl- and benzyl-isothiocyanates were identified from progoitrin ((2S)-2-hydroxybut-3-enyl-glucosinolate) and sinalbin (4-hydroxybenzyl-glucosinolate) degradation respectively. Addition of ascorbic acid to the reaction mixtures containing sinalbin and progoitrin caused the production of hydroxyloted degradation products usually associated with plant myrosinase metabolisation. The occurrence of the myrosinase system in B. brassicae is discussed in terms of similar allelochemical adaptation between the herbivore and its host plant. (C) 2002 Wiley-Liss, Inc. [less ▲]

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See detailSingle-domain antibody fragments with high conformational stability.
Dumoulin, Mireille ULg; Conrath, Katja; Van Meirhaeghe, Annemie et al

in Protein Science : A Publication of the Protein Society (2002), 11(3), 500-15

A variety of techniques, including high-pressure unfolding monitored by Fourier transform infrared spectroscopy, fluorescence, circular dichroism, and surface plasmon resonance spectroscopy, have been ... [more ▼]

A variety of techniques, including high-pressure unfolding monitored by Fourier transform infrared spectroscopy, fluorescence, circular dichroism, and surface plasmon resonance spectroscopy, have been used to investigate the equilibrium folding properties of six single-domain antigen binders derived from camelid heavy-chain antibodies with specificities for lysozymes, beta-lactamases, and a dye (RR6). Various denaturing conditions (guanidinium chloride, urea, temperature, and pressure) provided complementary and independent methods for characterizing the stability and unfolding properties of the antibody fragments. With all binders, complete recovery of the biological activity after renaturation demonstrates that chemical-induced unfolding is fully reversible. Furthermore, denaturation experiments followed by optical spectroscopic methods and affinity measurements indicate that the antibody fragments are unfolded cooperatively in a single transition. Thus, unfolding/refolding equilibrium proceeds via a simple two-state mechanism (N <--> U), where only the native and the denatured states are significantly populated. Thermally-induced denaturation, however, is not completely reversible, and the partial loss of binding capacity might be due, at least in part, to incorrect refolding of the long loops (CDRs), which are responsible for antigen recognition. Most interestingly, all the fragments are rather resistant to heat-induced denaturation (apparent T(m) = 60-80 degrees C), and display high conformational stabilities (DeltaG(H(2)O) = 30-60 kJ mole(-1)). Such high thermodynamic stability has never been reported for any functional conventional antibody fragment, even when engineered antigen binders are considered. Hence, the reduced size, improved solubility, and higher stability of the camelid heavy-chain antibody fragments are of special interest for biotechnological and medical applications. [less ▲]

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See detailLa libre disposition du corps humain à la lumière de la jurisprudence Perruche
Leleu, Yves-Henri ULg

in Revue Générale des Assurances et des Responsabilités (2002)

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See detailPosidonia Oceanica Meadow: A Low Nutrient High Chlorophyll (LNHC) System?
Gobert, Sylvie ULg; Laumont, N.; Bouquegneau, Jean-Marie ULg

in BMC Ecology (2002), 2

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the ... [more ▼]

BACKGROUND: In spite of very low nutrient concentrations in its vicinity - both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high biomass and productivity. We measured the nutrient fluxes from the sediment into the water enclosed among the leaf shoots ("canopy water") to determine if it is possible source of nutrients for P. oceanica leaves. RESULTS: During the summer, the canopy water appears to act as a nutrient reservoir for the plant. During that period, the canopy water layer displays both a temperature 0.5 degrees C cooler than the upper water column, and a much higher nutrient content, as shown in this work using a very simple original technique permitting to sample water with a minimal disturbance of the water column's vertical structure.Despite low nutrient concentrations in pore water, mean net fluxes were measured from the sediment to the canopy water. These fluxes are sufficient to provide 20% of the mean daily nitrogen and phosphorus requirement of the P. oceanica shoots. CONCLUSION: An internal cycling of nutrients from P. oceanica senescent leaves was previously noted as an efficient strategy to help face low nutrient availability. The present study points out a second strategy which consists in holding back, in the canopy, the nutrients released at the water-sediment interface. This process occurs when long leaves, during poor nutrient periods in the water column, providing, to P. oceanica, the possibility to develop, high biomass, high chlorophyll quantities in low nutrient environment (a Low Nutrients High Chlorophyll system). [less ▲]

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See detailPost-mortem findings and causes of death of harbour porpoises (Phocoena phocoena) stranded from 1990 to 2000 along the coastlines of Belgium and northern France
Jauniaux, Thierry ULg; Petitjean, D.; Brenez, C. et al

in Journal of Comparative Pathology (2002), 126(4), 243-253

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses ... [more ▼]

Between the,ears 1990 and 2000, an attempt was made to determine the causes of death of 55 harbour porpoises stranded along the Belgian and northern French coasts. From 1990 to 1996, only five carcasses were collected as against seven in 1997, eight in 1998, 27 in 1999 and eight in 2000. The sex ratio was normal and most of the animals were juvenile. The most common findings were emaciation, severe parasitosis and pneumonia. A few cases of fishing net entanglement were observed. The main microscopical lesions were acute pneumonia, massive lung oedema, enteritis, hepatitis and gastritis. Encephalitis was observed in six cases. No evidence of morbillivirus infection was detected. Pneumonia was associated with bacteria or parasites, or both. The causes of death and the lesions were similar to those previously reported in other countries bordering the North Sea. The cause of the increased numbers of carcasses in 1999 was unclear but did not include viral epizootics or net entanglement. A temporary increase in the porpoise populatiou in the southern North Sea may have been responsible. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailImmunocytochemical study of subcellular distribution of bovine leukaemia virus regulatory Tax protein.
Russev, R.; Shikova, E.; Portetelle, Daniel ULg et al

in Annals of Oncology (2002), 13(2), 14

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See detailMR1905401,, Khan, A. R. and Elkamel, A., Mathematical model for heat transfer mechanism for particulate System, Appl. Math. Comput.
Rochus, Pierre ULg

in Applied Mathematics and Computation (2002), 129(2-3), 295--316

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See detailLe roman poétique en 1929. Nord, entre fantastique réel et réalisme magique
Denis, Benoît ULg

in Textyles : Revue des Lettres Belges de Langue Française (2002), (21), 31-40

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See detail'Love Poems for the Millennium'
Delville, Michel ULg

in Literary Review (2002), 46(1), 196-199

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See detailLe contrat de travail et la signature électronique
Kefer, Fabienne ULg; Barth, H.

in Orientations : la Revue du Droit Social et de la Gestion du Personnel (2002)

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See detailPour une sémiologie historique de l'acte photographique
Havelange, Carl ULg

in Revue de la Faculté des Lettres d'El Jadida (2002)

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