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See detailDifference in risk factors for postoperative nausea and vomiting.
Stadler, Michaela; Bardiau, Françoise ULiege; Seidel, Laurence ULiege et al

in Anesthesiology (2003), 98(1), 46-52

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for ... [more ▼]

BACKGROUND: It is commonly stated that risk factors for postoperative nausea are the same as for vomiting. The authors designed a prospective study to identify and differentiate the risk factors for postoperative nausea and vomiting in various surgical populations in a clinical audit setting. METHODS: The study included 671 consecutive surgical inpatients, aged 15 yr or more, undergoing various procedures. The study focused on postoperative nausea visual analog scale scores every 4 h and vomiting episodes within 72 h. Both vomiting and retching were considered as emetic events. Patient-, anesthesia-, and surgery-related variables that were considered to have a possible effect on the proportion of patients experiencing postoperative nausea and/or vomiting were examined. The bivariate Dale model for binary correlated outcomes was used to identify selectively the potential risk factors of postoperative nausea and vomiting. RESULTS: Among the 671 patients in the study, 126 (19%) reported one or more episodes of nausea, and 66 patients (10%) suffered one or more emetic episodes during the studied period. There was a highly significant association between the two outcomes. Some risk factors were predictive of both nausea and vomiting (female gender, nonsmoking status, and general anesthesia). History of migraine and type of surgery were mainly responsible for nausea but not for vomiting. The predictive effect of risk factors was controlled for postoperative pain and analgesic drugs. CONCLUSION: This study shows that differences exist in risk factors of postoperative nausea and vomiting. These could be explained by differences in the physiopathology of the two symptoms. [less ▲]

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See detailPrincipal component analysis of Piezo-Sensor Array for damage localization
De Boe, Pascal; Golinval, Jean-Claude ULiege

in Structural Health Monitoring (2003), 2(2), 137-144

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with ... [more ▼]

This paper focuses on applying statistical process control techniques, based on principal component analysis, to vibration-based damage diagnosis. It is well known that localized structural damages with relative small amplitude do not affect much the global modal response of the structure, at least at low frequencies. Nevertheless, it can be expected that the local dynamic behavior of a damaged structural subcomponent is significantly affected. Assuming that each structural subcomponent is monitored, local structural damage, with relative small amplitude, will only affect a particular sensor without affecting significantly the response of the others. By applying a principal component analysis on the sensor time responses, it is possible to see that any change of one particular sensor will affect the subspace spanned by the complete sensor response set. The subspace corresponding to the damaged structure can then be compared with the subspace of an initial state in order to diagnose possible damage. The principal component analysis may also be performed for every potential subset of damaged sensors in order to identify the involved sensor, and, therefore, the damaged structural component. The spatial information given by the distributed sensors (e.g. piezoelectric laminates) can be used to forecast structural damages on a critical area but damage localization is also possible with classical sensors (e.g. accelerometers). The damage may be located as the errors attain the maximum at the sensors instrumented in the damaged substructures. [less ▲]

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See detailEstimation of habitat quality based on plant community, and effects of isolation in a network of butterfly habitat patches
Sawchik, J.; Dufrêne, Marc ULiege; Lebrun, Philippe

in Acta Oecologica (2003), 24(1), 25-33

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ... [more ▼]

Minimum viable site networks are crucial for many threatened species but their design is always a difficult procedure. The present study investigated methods to estimate habitat quality of patches, in an ecological network for five butterfly species (Brenthis ino, Clossiana selene, Lycaena helle, Lycaena hippothoe, Proclossiana eunomia) inhabiting wet meadows. Abundance predictions were performed on the basis of botanical relevés with a multiple-species approach combining canonical correspondence analysis and multiple regression. Models are defined on a reference site set and are evaluated on a test site set. All the fitted models predicted the abundance of the butterfly species considerably well (from 61 to 86% of the variation). We evaluated the potential consequences of isolation on local populations, by comparing predicted and observed abundance. It was expected that greater differences would be observed when sites were more isolated. On the test set, differences between predicted and observed abundance were largely correlated to site isolation for L. helle and P. eunomia. The most isolated sites had greater chances to be empty, even if they had high-quality habitat. Reciprocally, when the sites were less isolated, the abundance observed was always greater than predicted, seeming to confirm the role of rescue effects. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved. [less ▲]

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See detailThe contribution of recollection and familiarity to recognition memory : A study of the effects of test format and aging
Bastin, Christine ULiege; Van der Linden, Martial ULiege

in Neuropsychology (2003), 17(1), 14-24

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the ... [more ▼]

Whether the format of a recognition memory task influences the contribution of recollection and familiarity to performance is a matter of debate. The authors investigated this issue by comparing the performance of 64 young (mean age = 21.7 years; mean education = 14.5 years) and 62 older participants (mean age = 64.4 years; mean education = 14.2 years) on a yes–no and a forced-choice recognition task for unfamiliar faces using the remember– know–guess procedure. Familiarity contributed more to forced-choice than to yes–no performance. Moreover, older participants, who showed a decrease in recollection together with an increase in familiarity, performed better on the forced-choice task than on the yes–no task, whereas younger participants showed the opposite pattern. [less ▲]

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See detailHaplotype diversity of the myostatin gene among beef cattle breeds
Dunner, S.; Miranda, M. E.; Amigues, Y. et al

in Genetics, Selection, Evolution (2003), 35(1, JAN-FEB), 103-118

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were ... [more ▼]

A total of 678 individuals from 28 European bovine breeds were both phenotyped and analysed at the myostatin locus by the Single Strand Conformation Polymorphism (SSCP) method. Seven new mutations were identified which contribute to the high polymorphism (1 SNP every 100 bp) present in this small gene; twenty haplotypes were described and a genotyping method was set up using the Oligonucleotide Ligation Assay (OLA) method. Some haplotypes appeared to be exclusive to a particular breed; this was the case for 5 in the Charolaise (involving mutation Q204X) and 7 in the Maine-Anjou (involving mutation E226X). The relationships between the different haplotypes were studied, thus allowing to test the earlier hypothesis on the origin of muscular hypertrophy in Europe: muscular hypertrophy (namely m821 (del11)) was mainly spread in different waves from northern Europe milk purpose populations in most breeds; however, other mutations (mostly disruptive) arose in a single breed, were highly selected and have since scarcely evolved to other populations. [less ▲]

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See detailChromomycose autochtone chez une patiente immunodéprimée.
Quatresooz, Pascale ULiege; Dethier, F.; Pierard, Gérald ULiege

in Dermatologie Actualité (2003), 74

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See detailExcitability of visual V1-V2 and motor cortices to single transcranial magnetic stimuli in migraine: a reappraisal using a figure-of-eight coil.
Bohotin, V.; Fumal, Arnaud ULiege; Vandenheede, M. et al

in Cephalalgia : An International Journal of Headache (2003), 23(4), 264-70

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13 ... [more ▼]

We used transcranial magnetic stimulation (TMS) with a figure-of-eight coil to excite motor and visual V1-V2 cortices in patients suffering from migraine without (MO) (n = 24) or with aura (MA) (n = 13) and in healthy volunteers (HV) (n = 33). Patients who had a migraine attack within 3 days before or after the recordings were excluded. All females were recorded at mid-cycle. Single TMS pulses over the occipital cortex elicited phosphenes in 64% of HV, 63% of MO and 69% of MA patients. Compared with HV, the phosphene threshold was significantly increased in MO (P = 0.001) and in MA (P = 0.007), but there was no difference between the two groups of migraineurs. The motor threshold tended to be higher in both migraine groups than in HV, but the differences were not significant. In conclusion, this study shows that two-thirds (64.86%) of patients affected by either migraine type present an increased phosphene threshold in the interictal period, which suggests that their visual cortex is hypoexcitable. [less ▲]

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See detailPharmacological evaluation of the novel thromboxane modulator BM-567 (II/II). Effects of BM-567 on osteogenic sarcoma-cell-induced platelet aggregation
De Leval, X.; Benoit, V.; Delarge, J. et al

in Prostaglandins, Leukotrienes, and Essential Fatty Acids (2003)

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See detailIntroduction of australian diploid cotton genetic variation into upland cotton
Ahoton, L.; Lacape, Jm.; Baudoin, Jean-Pierre ULiege et al

in Crop Science (2003), 43(6), 1999-2005

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See detailInvestigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry
Pochet, L.; Dieu, M.; Frederick, R. et al

in Tetrahedron (2003)

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See detailPhysiology of reproduction and endocrinology in cervids. A review
Drion, Pierre ULiege; Hanzen, Christian ULiege; Wirth, Delphine - in memoriam et al

in Annales de Médecine Vétérinaire (2003), 147(5), 291-313

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract ... [more ▼]

Knowledge about cervids are rapidly growing. This work aims to present the more recent scientific information on reproductive physiology and endocrinology of the cervids: anatomy of the genital tract, length of breeding season, parameters and endocrinology of the reproductive cycle, endocrinology of pregnancy. It also aims to highlight differences between cervids and domestic ruminants such as embryonic diapause observed in Capreolus capreolus. [less ▲]

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See detail3-Isopropylamino-7-nitro-1,4,2-benzodithiazine 1,1-dioxide
Dupont, L.; Somers, F.; De Tullio, Pascal ULiege et al

in Acta Crystallographica (2003)

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See detailImpact of medical specialist' locus of control on communication skills in oncological interviews
Libert, Y.; Janne, P.; Razavi, D. et al

in British Journal of Cancer (2003), 88

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See detailLa climatologie
Erpicum, Michel ULiege; Alexandre, Jean ULiege

in Bulletin de la Société Géographique de Liège (2003), 43(2003), 79-88

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See detailMolecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.
Blott, Sarah; Kim, Jong-Joo; Moisio, Sirja et al

in Genetics (2003), 163(1), 253-66

We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome ... [more ▼]

We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population. [less ▲]

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See detailSynthesis and characterization of new inorganic polymeric composites based on kaolin or white clay and on ground-granulated blast furnace slag
Lecomte, I.; Liégeois, Monique ULiege; Rulmont, André ULiege et al

in Journal of Materials Research (2003), 18(11), 2571-2579

Alkali activation of dehydroxylated kaolin or clay yielded high-strength polymeric materials, so-called geopolymers. They were synthesized by mixing the aluminosilicate with solutions of sodium ... [more ▼]

Alkali activation of dehydroxylated kaolin or clay yielded high-strength polymeric materials, so-called geopolymers. They were synthesized by mixing the aluminosilicate with solutions of sodium metasilicate and KOH followed by adding 45 wt.% of ground-granulated blast furnace slag. The influence of the aluminosilicate source, its activation temperature, and the order of mixing raw materials were studied on the workability of the blending paste, the microstructure, and the Vickers hardness of the geopolymer samples. The polymeric material is completely amorphous according to x-ray diffraction. Solid-state 27Al and 29Si magic-angle-spinning nuclear magnetic resonance showed that the geopolymer consists of AlO 4 and SiO 4 tetrahedra linked together through a polymeric network constituted by branched entities SiQ 4(4Al) and SiQ 4(3Al), but also by less-polymerized silicates SiQ 1 and SiQ 2. Scanning electron microscopy showed a homogeneous polymeric gel matrix containing unreacted slag (and quartz) grains; thermogravimetric analysis and differential scanning calorimetry exhibited a high content of water and an elevated melting point (1260 °C). Vickers hardness values are in the range of 200 MPa. [less ▲]

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See detailCompte-rendu de "La parola al testo. Scritti per Bice Mortara Garavelli"
Benzoni, Pietro ULiege

in Stilistica e metrica italiana (2003), III(3), 316-320

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See detailC.R. de La Chanson de Croissant en prose du XVe siècle (éd. M. Raby)
Henrard, Nadine ULiege

in Moyen Age (Le) (2003), CIX(3-4), 665-668

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See detail« Comment servir le souverain ». A propos d’un traité pseudo-platonicien inédit
Bauden, Frédéric ULiege; Ghersetti, Antonella

in Quaderni di Studi Arabi (2003), 20-21

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See detailLe trésor de reliques du Neufmoustier près de Huy. Une part de Terre sainte en pays mosan
George, Philippe ULiege

in Bulletin de la Commission Royale d'Histoire (2003)

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See detailEu10Mn6Sb13: A new ternary rare-earth transition-metal
Holm, A. P.; Park, S. M.; Condron, C. L. et al

in Inorganic Chemistry (2003), 42(15), 4660-4667

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 ... [more ▼]

A new transition-metal-containing Zintl compound, Eu10Mn6Sb13, was prepared by a high-temperature Sn-flux synthesis. The structure was determined by single-crystal X-ray diffraction. Eu10Mn6Sb13 crystallizes in the monoclinic space group C2/m with a = 15.1791(6) Angstrom, b = 19.1919(7) Angstrom, c = 12.2679(4) Angstrom, beta = 108.078(1)degrees, Z = 4 (R1 = 0.0410, wR2 = 0.0920), and T = 90(2) K. The structure of Eu10Mn6Sb13 is composed of double layers of Mn-centered tetrahedra separated by Eu2+ cations. The double layers are composed of edge- and corner-sharing Mn-centered tetrahedra which form cavities occupied by Eu2+ cations and [Sb-2](4-) dumbbells. Linear [Sb-3](5-) trimers bridging two tetrahedra across the cavity are also present. Bulk susceptibility data indicate paramagnetic behavior with a ferromagnetic component present below 60 K. Temperature-dependent electrical resistivity measurements show semiconducting behavior above 60 K (E-a = 0.115(2) eV), a large and unusually sharp maximum in the resistivity at similar to40 K, and metallic behavior below 40 K. Eu-151 Mossbauer spectra confirm that the europium is divalent with an average isomer shift of -11.2(1) mm/s at 100 K; the spectra obtained below 40 K reveal magnetic ordering of six of the seven europium sublattices and, at 4.2 K, complete ordering of the seven europium sublattices. [less ▲]

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See detailBinding and migration across fibronectin and VCAM-1 of cycling hematopoietic progenitor cells.
Gothot, André ULiege; Giet, Olivier ULiege; Huygen, Sandra et al

in Leukemia & Lymphoma (2003), 44(8), 1379-83

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem ... [more ▼]

Using different experimental approaches, it has been established that transplantability of hematopoietic/stem progenitor cells is ineffective during transit through the cell cycle. Although primitive stem cells are responsive to mitogenic stimulation in optimized ex vivo conditions, defective engraftment of generated cells may limit their detection in standard transplantation models as well as their use in clinical cell therapy. The activation level of adhesion receptors is modulated by stimulation of cytokine receptors via "inside-out" signaling. This prompted us to study the interactions of progenitor cells with fibronectin (Fn) in different phases of the cell cycle. We first demonstrated that adhesion to Fn was stimulated in S/G2 + M as compared to G0/G1, in ex vivo cultured CD34+ cells, with a predominant usage of very late antigen (VLA)-5 over that of VLA-4. We next determined that maximal Fn binding in active phases of the cell cycle limited cell motility toward stromal cell-conditioned medium. It was also observed that VLA-4 and VLA-5 ability to mediate adhesion or migration varied independently during cell cycle transit. Finally, in synchronized progenitor cells executing a first cell cycle ex vivo, a reversible increase in Fn binding was associated with a reversible decrease in adhesion to vascular cell-adhesion molecule (VCAM)-1. Overall, these observations suggest that defective engraftment of cycling stem/progenitor cells may result, at least in part, from abnormal trafficking related to changes in the activation level of adhesion receptors. [less ▲]

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See detailAssessment of mechanobiological models for the numerical simulation of tissue differentiation around immediately loaded implants.
Geris, Liesbet ULiege; Van Oosterwyck, H.; Vander Sloten, J. et al

in Computer Methods in Biomechanics & Biomedical Engineering (2003), 6(5-6), 277-88

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different ... [more ▼]

Nowadays, there is a growing consensus on the impact of mechanical loading on bone biology. A bone chamber provides a mechanically isolated in vivo environment in which the influence of different parameters on the tissue response around loaded implants can be investigated. This also provides data to assess the feasibility of different mechanobiological models that mathematically describe the mechanoregulation of tissue differentiation. Before comparing numerical results to animal experimental results, it is necessary to investigate the influence of the different model parameters on the outcome of the simulations. A 2D finite element model of the tissue inside the bone chamber was created. The differentiation models developed by Prendergast, et al. ["Biophysical stimuli on cells during tissue differentiation at implant interfaces", Journal of Biomechanics, 30(6), (1997), 539-548], Huiskes et al. ["A biomechanical regulatory model for periprosthetic fibrous-tissue differentiation", Journal of Material Science: Materials in Medicine, 8 (1997) 785-788] and by Claes and Heigele ["Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing", Journal of Biomechanics, 32(3), (1999) 255-266] were implemented and integrated in the finite element code. The fluid component in the first model has an important effect on the predicted differentiation patterns. It has a direct effect on the predicted degree of maturation of bone and a substantial indirect effect on the simulated deformations and hence the predicted phenotypes of the tissue in the chamber. Finally, the presence of fluid also causes time-dependent behavior. Both models lead to qualitative and quantitative differences in predicted differentiation patterns. Because of the different nature of the tissue phenotypes used to describe the differentiation processes, it is however hard to compare both models in terms of their validity. [less ▲]

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See detailBildegedende diagnostik des gehirns beim alternden hund
Van Bree, H.; Gielen, I.; Peremans, K. et al

in Der Prattische Tierazt (2003)

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See detailIncidence and survival rate of women with cervical cancer in the Greater Amsterdam area.
BULK, Saskia ULiege; Visser, O.; Rozendaal, L. et al

in British journal of cancer (2003), 89(5), 834-9

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a ... [more ▼]

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100,000 women in 1988 to 5.9/100,000 in 2000 (P<0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2-2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions. [less ▲]

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See detailNMR study of surfactant molecules intercalated in montmorillonite and silylated montmorillonite
Grandjean, Jean ULiege; Bujdak, Janec; Komadel, Peter

in Clay Minerals (2003), 38

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See detailRedefining the role of psr in beta-lactam resistance and cell autolysis of Enterococcus hirae.
Sapunaric, Frédéric ULiege; Franssen, Christine; Stefanic, Patrick et al

in Journal of Bacteriology (2003), 185(20), 5925-35

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain ... [more ▼]

The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthesis repressor (Psr) to the beta-lactam resistance, growth, and cell autolysis of wild-type strain ATCC 9790 and resistant strain R40 of Enterococcus hirae was investigated by disruption or substitution of the corresponding pbp5 and psr genes by Campbell-type recombination. The resulting modifications were confirmed by hybridization and PCR. The low susceptibility of E. hirae to beta-lactams was confirmed to be largely dependent on the presence of PBP5. However, against all expectations, inactivation of psr in ATCC 9790 or complementation of R40 cells with psr did not modify the susceptibility to benzylpenicillin or the growth and cell autolysis rates. These results indicated that the psr gene does not seem to be involved in the regulation of PBP5 synthesis and consequently in beta-lactam resistance or in the regulation of cell autolysis in E. hirae. [less ▲]

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See detailAnalytic quantification of solar lentigines lightening by a 2% hydroquinone-cyclodextrin formulation.
Petit, Ludivine; Pierard, Gérald ULiege

in Journal of the European Academy of Dermatology & Venereology (2003), 17(5), 546-9

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular ... [more ▼]

BACKGROUND: The innate melanin pigmentation of skin is modulated during lifetime by a series of factors, including ageing and chronic ultraviolet light exposure. Actinic lentigines may be of particular concern from a cosmetic point of view. Conventional hypopigmenting agents are usually deceptive. Using cyclodextrins to form inclusion compounds with these agents might represent a more active drug delivery system. OBJECTIVE: To assess sensitive and objective methods predicting the effects of a 2% hydroquinone-cyclodextrin formulation on solar lentigines. STUDY DESIGN: Thirty Asian adults applied a 2% hydroquinone-cyclodextrin formulation once daily on solar lentigines of a forearm for 2 months. The other untreated forearm served as a control. Monthly assessments were performed using skin colorimetry and fluorescence video recording combined with image analysis. Corneomelametry following photodensitometry of cyanoacrylate skin surface strippings was performed after melanin staining of the samples. RESULTS: The control untreated solar lentigines showed no significant variations in the biometrological parameters. By contrast, the test formulation induced lightening of the solar lentigines. Corneomelametry disclosed improvement after 1 months' treatment, whereas the other assessments only reached significance after 2 months. CONCLUSIONS: A 2% hydroquinone-cyclodextrin formulation proved to be effective in lightening actinic lentigines. Corneomelametry predicted the effects discernible at a later stage by in vivo colour assessments of the melanin content. [less ▲]

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See detailIn vitro paradigms for the study of GnRH neuron function and estrogen effects.
Matagne, Valerie; LEBRETHON, Marie-Christine ULiege; Gerard, Arlette et al

in Annals of the New York Academy of Sciences (2003), 1007

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency ... [more ▼]

The elaboration of in vitro paradigms has enabled direct study of GnRH secretion and the regulation of this process. Common findings using different models are the pulsatile nature and calcium-dependency of GnRH secretion, the excitatory effect of glutamate, and the inhibitory or excitatory effect of GABA. Among the different paradigms, the fetal olfactory placode cultures exhibit the unique property of migration in vitro and may retain the capacity to undergo maturational changes in vitro. The short-term incubation of hypothalamic explants obtained at different ages enables one to study developmental changes as well. Estrogens may have important roles in the regulation of GnRH function and can act indirectly via the neighboring neuronal/glial apparatus and directly on GnRH neurons at the cell body and terminal levels. A direct effect is supported by the recent localization of ERalpha and ERbeta transcripts in GnRH neurons using most paradigms. Discrepant effects of estrogens on GnRH neurons were observed since GnRH biosynthesis is inhibited while GnRH secretion can be either stimulated, unaffected, or reduced. It is likely that the regulatory role of sex steroids including estradiol is very complex since it could involve direct and indirect effects on GnRH neurons through genomic and/or non-genomic mechanisms. [less ▲]

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See detailL’enseignement universitaire demain. Le cas de la Belgique francophone
Merenne-Schoumaker, Bernadette ULiege

in Géographes Associés (2003), (27), 63-65

Courte présentation de la situation de la géographie dans le monde universitaire francophone de Belgique au moment de la Réforme de Bologne

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See detailL’idole brisée : la droite belge francophone et la crise morale de la France (1934-1938)
Lanneau, Catherine ULiege

in Journal of Belgian History = Revue Belge d'Histoire Contemporaine = Belgisch Tijdschrift voor Nieuwste Geschiedenis (2003), XXXIII(1-2), 177-214

The French-speaking right wing in Belgium has always granted a paramount place to France in its ideological cosmography. The concept of everlasting France, of her “mission”, of the part she could play on ... [more ▼]

The French-speaking right wing in Belgium has always granted a paramount place to France in its ideological cosmography. The concept of everlasting France, of her “mission”, of the part she could play on the international scene are topics wondered about constantly in intellectual and middle-class circles. The thirties and mostly the Popular Front era provide the Conservatives with a splendid opportunity to describe the future of their cultural icon with awe: the more the international context is threatening, the more France seems to have become fragile, isolated and going down the slope. Using the news given by the national papers or the widely circulated Parisian press, right-wing Belgians brood, of course, about the eclipse of France’s might, but point chiefly to the moral crisis as its cause. Very often they feel some nostalgia for the “Ancien Régime” and see the origin of the worrying current phenomenon in the hated French Revolution. Lot of factors are intertwined in the definition of the moral decay, but some are particularly highlighted. France is accused to be invaded by foreigners (their Jewish origins and Marxist creeds being stressed); Free-Masonry has a bad influence, as well as laic teaching, perverting youth by its pacifist and internationalist leanings. The degeneration of the religious spirit is lamented on account of its influence on the birth rate: the “Elder Daughter of the Church” gets emptier and emptier, whereas the populations of Fascist Italy and Nazi Germany are blooming. Opposition to parliamentary system is to the fore, as the politico-financial scandals, the governmental instability, the disreputable ways of the politicians themselves contribute all to the idea of the moral crisis. A cultural decline is parallel, with a loss of spirituality in the French society, engulfed in materialism and coarseness. Their stinging attacks, their bombastic style show how deeply rooted is the “decay of France” thesis among Belgian Conservatives. Beyond the French case, they fear a possible contamination of Belgium and the disappearance of their own traditional but vanishing values. Their fears and frights have certainly played a part in the 1936 turn-around towards the so-called Belgian “politique d’indépendance” in foreign affairs. [less ▲]

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See detailIn vitro stability and immunoreactivity of the native and recombinant plant food 2S albumins Ber e 1 and SFA-8
Murtagh, M.; Archer, D.; Dumoulin, Mireille ULiege et al

in Clinical & Experimental Allergy : Journal of the British Society for Allergy & Clinical Immunology (2003), 8

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be ... [more ▼]

Background The ability of an intact protein to reach the circulatory system may be a prerequisite to allergenicity and many allergens, particularly those from plant foods, have been found to be consistently more resistant to digestion by pepsin than other proteins. Objective This study assessed the pepsinolytic stability of native 2S albumins from Brazil nut and sunflower seed and their recombinant versions produced in Pichia pastoris. The physicochemical stability of native and recombinant Brazil nut 2S albumins and recombinant sunflower seed 2S albumin was also assessed. The immunoreactivity of native Brazil nut 2S albumin and recombinant 2S albumins was compared using serum from patients allergic to Brazil nuts and animals immunized with native 2S albumins. Methods Digestibility was measured in simulated gastric fluid followed by SDS-PAGE. Circular dichroism spectra were used to analyse unfolding, as proteins were denatured by temperature, pH and guanidinium chloride. Immunoreactivity was assessed by immunoblot, RAST and ELISA. Results Brazil nut 2S albumin was significantly more resistant to proteolytic digestion than other Brazil nut proteins. It was also resistant to thermally and chemically induced denaturation. Equally high resistance to proteolytic digestion was observed with sunflower seed 2S albumin. The recombinant albumins mirrored their native counterparts in stability and immunoreactivity. Conclusion The important food allergen Brazil nut 2S albumin is as stable to digestion as is sunflower seed 2S albumin, whose allergenicity has yet to be determined. The 2S albumins and their recombinant counterparts could not be easily denatured by physicochemical treatments. The results suggest that 2S albumin is the only Brazil nut protein to reach the gut immune system intact. The production of properly folded recombinant proteins will facilitate mechanistic studies as well as diagnostic testing and antigen-based therapies. [less ▲]

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See detailProspective studyof CD4 and CD8 T-lynphocyte apoptosis as a marker for radiation induced late effects in 399 individual patients
Ozsahin; Crompton; Shi et al

in International Journal of Radiation, Oncology, Biology, Physics (2003), 55(2), 551-552

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See detailPetrology of the Lyngdal granodiorite (southern Norway) and the role of fractional crystallization in the genesis of Proterozoic rapakivi-like granites
Bogaerts, Michel; Scaillet, Bruno; Liégeois, Jean-Paul ULiege et al

in Precambrian Research (2003), 124(2-4), 149-184

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See detailElectrophysiological studies in migraine: a comprehensive review of their interest and limitations
Ambrosini, Anna; Maertens De Noordhout, Alain ULiege; Sandor, P. et al

in Cephalalgia : An International Journal of Headache (2003), 23(Suppl. 1), 13-31

Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory ... [more ▼]

Electrophysiological methods may help to unravel some of the pathophysiological mechanisms of migraine. Lack of habituation is the principal and most reproducible interictal abnormality in sensory processing in migraineurs. It is found in evoked potential (EP) studies for every stimulation modality including nociceptive stimuli, and it is likely to be responsible for the increased intensity dependence of EP. We have hypothesized that deficient EP habituation in migraine could be due to a reduced preactivation level of sensory cortices because of hypofunctioning subcortico-cortical aminergic pathways. This is not in keeping with simple hyperexcitability of the cortex, which has been suggested by some, but not all, studies of transcranial magnetic stimulation (TMS). A recent study of the effects of repetitive TMS on visual EP strongly supports the hypothesis that migraine is characterized by interictal cortical hypoexcitability. With regard to pain mechanisms in migraine, electrophysiological studies of trigeminal pathways using nociceptive blink and corneal reflexes have confirmed that sensitization of central trigeminal nociceptors occurs during migraine attacks. [less ▲]

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See detailMMP-2 and MMP-9 synergize in promoting choroidal neovascularization
Lambert, Vincent ULiege; Wielockx, B.; Munaut, Carine ULiege et al

in FASEB Journal (2003), 17(15), 2290-2292

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but ... [more ▼]

Matrix metalloproteinase 2 (MMP-2) and MMP-9 are increased in human choroidal neovascularization (CNV) occurring during the exudative most aggressive form of age-related macular degeneration (AMD), but their precise role and potential interactions remain unclear. To address the question of MMP-2 and MMP-9 functions, mice deficient in the expression of MMP-2 (MMP-2 KO), MMP-9 (MMP-9 KO), and both MMP-2 and MMP-9 (MMP-2,9 KO) with their corresponding wild-type mice (WT) underwent CNV induction by laser-induced rupture of the Bruch's membrane. Both the incidence and the severity of CNV were strongly attenuated in double deficient compared with single gene deficient mice or corresponding WT controls. The reduced neovascularization was accompanied by fibrinogen/fibrin accumulation. Furthermore, overexpression of the endogenous MMP inhibitors TIMP-1 or TIMP-2 (delivered by adenoviral vectors) in WT mice or daily injection of a synthetic and gelatinase selective MMP inhibitor (Ro 26-2853) significantly decreased the pathological reaction. These findings suggest that MMP-2 and MMP-9 may cooperate in the development of AMD and that their selective inhibition represents an alternative strategy for the treatment of choroidal neovascularization. [less ▲]

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See detailSuivi de la végétation en zone sèche par des produits d‘information dérivés de l‘imagerie spatiale
Crépeau, Christian; Bennouna, Taoufiq; Bicheron, Patrice et al

in Science et changements planétaires / Sécheresse (2003), 14(1), 56-57

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See detailRole of acetaldehyde in ethanol-induced conditioned taste aversion in rats
Escarabajal, Dolores M.; De Witte, Philippe; Quertemont, Etienne ULiege

in Psychopharmacology (2003), 167(2), 130-136

Rationale: In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. Objectives: The present ... [more ▼]

Rationale: In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing and/or aversive effects of ethanol. Objectives: The present study reexamined the role of acetaldehyde in ethanol-induced conditioned taste aversion (CTA). A first experiment compared ethanol- and acetaldehyde-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was administered before conditioning with either ethanol or acetaldehyde to investigate the effects of acetaldehyde accumulation. Methods: A classic CTA protocol was used to associate the taste of a saccharin solution with either ethanol or acetaldehyde injections. In experiment 1, saccharin consumption was followed by injections of either ethanol (0, 0.5, 1.0, 1.5 or 2.0 g/kg) or acetaldehyde (0, 100, 170 or 300 mg/kg). In experiment 2, the rats were pretreated with either saline or cyanamide (25 mg/kg) before conditioning with either ethanol or acetaldehyde. Results: Both ethanol and acetaldehyde induced significant CTA. However, ethanol produced a very strong CTA relative to acetaldehyde that induced only a weak CTA even at toxic doses. Cyanamide pretreatments significantly potentiated ethanol- but not acetaldehyde-induced CTA. Conclusions: The present results indicate that ethanol-induced CTA does not result from brain acetaldehyde effects. In contrast, it is suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA. Our results also suggest that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced CTA. [less ▲]

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See detailEstrogens reduce the expression of YKL-40 in the retina: Implications for eye and joint diseases
Rakic, Jean-Marie ULiege; Lambert, Vincent ULiege; Deprez, Manuel ULiege et al

in Investigative Ophthalmology & Visual Science (2003), 44(4), 1740-1746

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially ... [more ▼]

PURPOSE. To identify modifications in the gene expression profile of the ocular posterior segment in ovariectomized (OVX) mice with and without substitutive estradiol therapy and to select differentially expressed genes that could be relevant to the natural history of human age-related macular degeneration (AMD). METHODS. Chorioretinal tissues from two groups of 25 treated and untreated OVX mice were analyzed by using cDNA array technology. The expression level of selected genes was confirmed in triplicate by RT-PCR and related to the estrogenic status of the animals. Expression of the YKL-40 gene was further investigated in intact or diseased human retinas and in a murine model of experimental choroidal neovascularization (CNV), using laser pressure catapulting. RESULTS. Of the approximately, 10,000 genes screened, only YKL-40 expression was significantly downregulated by 17-beta-estradiol. YKL-40 was expressed in intact human neural retina and in the RPE. The expression of YKL-40 was upregulated in experimental CNV and in neovascular membranes extracted from patients affected by the exudative form of AMD. CONCLUSIONS. These observations indicate that YKL-40 expression in the retina is modulated by serum levels of estradiol. This protein could be relevant to the development of AMD and is also a new mediator to take into account when evaluating the broad consequences of hormonal replacement therapy. [less ▲]

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See detailStructural integral monitoring by vibration measurements
Yan, Ai-Min; De Boe, Pascal; Golinval, Jean-Claude ULiege

in FM2003 - Structural Integrity and Materials Aging (2003)

This paper presents a comparative study on several approaches of structural damage diagnosis based on vibration measurements. Stochastic subspace identification method is used to identify modal parameters ... [more ▼]

This paper presents a comparative study on several approaches of structural damage diagnosis based on vibration measurements. Stochastic subspace identification method is used to identify modal parameters and to generate a Kalman prediction model, which are taken as damage-sensitive features for structural damage detection. A statistical process control technique based on principal component analysis (PCA) is also presented. An improvement and enhancement of PCA are proposed. It is assumed that without damage, structural responses should remain approximately in a hyperplane defined by the principal directions of data. Damage localization is explored with these methods. As only the measured output signals are needed, the methods are convenient for an on-line monitoring. The efficiency and limitation of the proposed methods are illustrated by a practical application. [less ▲]

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See detailSurface Initiated Polymerization of Styrene from Carboxylic Acid Functionalized Polypyrrole Coated Electrode
Roux, Stéphane; Duwez, Anne-Sophie ULiege; Demoustier-Champagne, Sophie

in Langmuir (2003), 19

Surface initiated radical polymerization (SIRP) is an elegant and efficient method to produce polymer chains attached to surfaces with a high graft density. Growth of polymer chains from a gold surface ... [more ▼]

Surface initiated radical polymerization (SIRP) is an elegant and efficient method to produce polymer chains attached to surfaces with a high graft density. Growth of polymer chains from a gold surface requires the formation of a self-assembled monolayer (SAM) of thiols functionalized by reactive groups (alcohol or carboxylic acid) in order to covalently bind free radical initiator species. However, thiol desorption induced by the temperature imposed for polymerization impedes the growth of polymer chains.Wepropose therefore to coat a gold electrode with a polypyrrole (PPy) derivative containing carboxylic acid pendant groups. The resulting conducting polymer layer was shown to be strongly attached to the surface. Grafting of the initiator (azo compound) and SIRP of styrene were successfully performed on this organic layer, as demonstrated by X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectrometry (TOF SIMS), and contact angle measurements. The roughness, the morphology, and the surface uniformity of the films were investigated by atomic force microscopy (AFM). Finally, cyclic voltammetry experiments were carried out to study the influence of the polystyrene layer on the electrochemical behavior of the conducting polymer [less ▲]

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See detailLa sentence arbitrale
Caprasse, Olivier ULiege

in Actualités du Droit (2003), 3

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See detailFlow cytometric cerebrospinal fluid analysis in children
Häusler, M.; Sellhaus, B.; Schweizer, K. et al

in Pathology Research and Practice (2003), 199(10), 667-675

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume ... [more ▼]

Flow cytometry (FC) is of increasing importance for the analysis of cerebrospinal fluid (CSF) lymphocytes because of its ability to detect a large spectrum of cellular characteristics (granularity, volume, surface antigen expression) even in small amounts of cells. Data on CSF FC in children are very limited. Here, we summarize our 3-year experience of CSF FC routinely performed in pediatric patients with assumed inflammatory central nervous system (CNS) disease. Among 109 samples sent for analysis, flow cytometric detection of major leukocyte subsets was possible in 78% (85 out of 109), which exceeds the 31% rate of our retrospective microscopic pediatric control group. Apart from physiologic lymphocytes (100%) or monocytes (48%), 11 out of these 85 samples showed granulocytes, two showed proliferated monocytes, and nine displayed proliferated lymphocytes. In most children, the proliferated lymphocytes consisted of a polyclonal population of CD4+ and CD8+ T cells. Compared with literature data, eight children showed abnormally composed lymphocyte subsets (surface antigen expression) within the main lymphocyte population. However, none of these changes was specific for distinct diseases or allowed a distinction between patients with and without primary inflammatory processes. These data suggest that CSF FC may be the most effective modality to differentiate major CSF leukocyte subsets. At present, further differentiation of distinct cell populations, such as proliferated lymphocytes, is of limited clinical impact. This may, however, gain increasing interest in the future. [less ▲]

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See detailPotato Tuber Phospholipids Contain Colneleic Acid In The 2-Position
Fauconnier, Marie-Laure ULiege; Williams, Td.; Marlier, M. et al

in FEBS Letters (2003), 538(1-3),

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See detailSeismic triggering of landslides, Part A: Field evidence from the Northern Tien Shan
Havenith, Hans-Balder ULiege; Strom, A.; Jongmans, D. et al

in Natural Hazards & Earth System Sciences (2003), 3

Landslides triggered by strong earthquakes often caused most of the global damage and most of all casualties related to the events, such as shown by the M = 7.7 Peru earthquake in 1970, by the M = 7.6 El ... [more ▼]

Landslides triggered by strong earthquakes often caused most of the global damage and most of all casualties related to the events, such as shown by the M = 7.7 Peru earthquake in 1970, by the M = 7.6 El Salvador earthquake in 2001 or by the M = 7.4 Khait (Tajikistan) earthquake in 1949. The obvious impact of a landslide on the population is directly related to its movement. Yet, prediction of future failure potential and hence future risk to population is necessary in order to avoid further catastrophes and involves the analyses of the origin of seismic instability. The seismic landslide potential is mainly determined by the interaction between the regional seismic hazard and local geological conditions. At a local scale, seismic factors interfering with geological conditions can produce site-specific ground motions. The influence of such Site Effects on instability is the principal topic of this paper, which is divided into two parts, A and B. The present Part A is concerned with the correlation of field data with observed instability phenomena. Field data were obtained on mainly three landslide sites in the Northern Tien Shan Mountains in Kyrgyzstan, Central Asia. Geophysical prospecting, earthquake recordings, geological observation, trenching and geotechnical tests were the main investigation tools. The collected information gives an insight in the geological background of the slope failure and allows us to roughly infer failure mechanisms from field evidence. A detailed analysis of the susceptibility of a mechanism to specific geological conditions will be shown in Part B. [less ▲]

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See detailBook Review: Theories of Endogenous Regional Growth: Lessons for Regional Policies,
Artige, Lionel ULiege; Nicolini, Rosella

in Journal of Regional Science (2003), 43(2), 403-406

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See detailModel Updating Based on Frequency Response Functions Using A General Finite Element Code
Yan, Ai-Min; Golinval, Jean-Claude ULiege

in European Journal of Mechanical and Environmental Engineering (2003), 48(3), 149-162

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ... [more ▼]

Model updating techniques using frequency response function (FRF) data are studied in this paper. The numerical techniques are discussed for implementation with a large commercial finite element (FE ) code. System equivalent reduction expansion process is adopted to reduce the complete FE solutions onto the experimental degrees of freedom. The rank-deficiency difficulty with this method is overcome using either of two numerical techniques: diagonal perturbation and singular value decomposition. This second technique is also used in solving the updating equation. Experimental FRF data are compared with the FE solutions, and the updated model parameters are obtained via an iteration procedure. A simplified frequency domain assurance criterion is proposed to evaluate the correlation between the FE model and the measured structure at the chosen frequencies. After verifying the efficiency of the methods with several benchmark tests, the program is applied to an aeroplane model test. Some conclusions are given and remaining problems illustrated. [less ▲]

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See detailAnatomische, histologische en immunologische aspecten van de tonsille bij het schaap in het kader van de BSE problematiek
Cocquyt, G.; Gabriel, Annick ULiege; Van den Broeck, W.

in Vlaams Diergeneeskundig Tijdschrift (2003), 72

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See detailCompetition Policy and the Euromed Partnership
Petit, Nicolas ULiege; Geradin, Damien

in European Foreign Affairs Review (2003)

This paper seeks to provide a critical assessment of the efforts made by the EC to stimulate the development of competition laws in the Mediterranean countries with which it is engaged in partnership ... [more ▼]

This paper seeks to provide a critical assessment of the efforts made by the EC to stimulate the development of competition laws in the Mediterranean countries with which it is engaged in partnership agreements. It reviews the content of the competition provisions of the association agreements, as well as their effectiveness. In then examines the regular calls for convergence on the EC competition law model to which Mediterranean countries are object. There is indeed room for debate regarding the opportunity, as well as the nature of such convergence. The paper concludes that a deep convergence approach, whereby the non-candidate Partner countries would transpose EC competition rules in their domestic legal order, would provide many benefits for both the EC and these countries. [less ▲]

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See detailCalculation of optical absorption spectra of hydrogenated Si clusters: Bethe-Salpeter equation versus time-dependent local-density approximation
Benedict, L. X.; Puzder, A.; Williamson, A. J. et al

in Physical Review. B : Condensed Matter (2003), 68(8), 85310-1-85310-85310-885310-85310-8

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE ... [more ▼]

We present calculations of the optical absorption spectra of clusters SiH 4, Si 10H 16, Si 17H 36, Si 29H 24, and Si 35H 36, as determined from two different methods: the Bethe-Salpeter equation (BSE) with a model dielectric function, and the time-dependent density-functional theory within the adiabatic local-density approximation (TDLDA). Single-particle states are obtained from local-density approximation (LDA) calculations and, for the BSE calculation, a quasiparticle gap correction is provided by quantum Monte Carlo calculations. We find that the exchange-correlation kernel of the TDLDA has almost no effect on the calculated spectra, while the corresponding attractive part of the electron-hole interaction of the BSE produces enhanced absorptive features at low energies. For the smallest cluster SiH 4, the two methods produce markedly different results, with the TDLDA spectra appearing closer to the experimental result. The gross features of the TDLDA and BSE spectra for larger clusters are however similar, due to the strong repulsive Coulomb kernel present in both treatments [less ▲]

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See detailComment j'explore ... les secrets d'une meta-analyse.
Scheen, André ULiege

in Revue Médicale de Liège (2003), 58(1), 41-6

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several ... [more ▼]

Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several studies by a single weighted average whose precision is indicated by the confidence interval. A standardized graphical representation allows, at first glance, to derive a lot of useful information, especially the number of studies taken into account for the analysis, the mean effect observed in each study with its confidence interval, the relative size (number of subjects) of each study, the homogeneity/heterogeneity of between-study results, finally the overall mean effects with its confidence interval. The meta-analysis plays a key-role in epidemiology, for the evaluation of a risk or a protective factor, and in therapeutics, for summarizing the results of numerous clinical trials with a specific drug or a pharmacological class in a given disease. [less ▲]

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See detailScepticisme et science nouvelle dans les Dialogues faits à l'imitation des Anciens
Torero-Ibad, Alexandra ULiege

in Corpus, revue de philosophie (2003), 43

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See detailCompte rendu de Seuphor. N° spécial d’Archipel, Cahier international de littérature
Robert, Laurent ULiege

in Textyles : Revue des Lettres Belges de Langue Française (2003), 23

Compte rendu d'un ouvrage contenant des documents du poète Michel Seuphor et apportant quelques précisions d'ordre biographique sur cet auteur

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See detailWhat's alternative about alternative food networks?
Whatmore, Sarah; Stassart, Pierre M ULiege; Rentjes, Henk

in Environment & Planning A (2003), 35

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See detailNegative association between smoking and anti-saccharomyces cerevisiae antibodies in Crohn's disease
Van Kemseke, Catherine ULiege; Belaiche, Jacques ULiege; Steeman, C. et al

in Acta Gastro-Enterologica Belgica (2003), 66(1, Jan-Mar), 1-6

Background: Crohn's disease (CD) is a polygenic multifactorial heterogeneous disease. Anti-Saccharomyces Cerevisiae antibodies (ASCA) correlate highly with CD and are present in 50-80% of patients. The ... [more ▼]

Background: Crohn's disease (CD) is a polygenic multifactorial heterogeneous disease. Anti-Saccharomyces Cerevisiae antibodies (ASCA) correlate highly with CD and are present in 50-80% of patients. The reason for ASCA positivity or negativity in CD is unknown. The aim of our work was to analyse clinical, epidemiological and genetic characteristics in ASCA + or ASCA- CD patients. Methods : 113 patients with CD were tested for ASCA (IgA and IgG) by using a commercial kit (Medipan Diagnostica). Age, gender, systemic manifestations, familial form of disease, age at diagnosis, location and behaviour of the disease, smoking habit as well as genotyping for -308 TNF gene polymorphisms were determined. Results : 38.9% CD patients were negative for both IgA and IgG ASCA while 61.1% were ASCA positive (respectively IgA and IgG : 31.9%; IgA only : 9.7%; IgG only : 19.5%). The only significant difference between ASCA+ and ASCA- patients was for smoking habit : there were 29% smokers in ASCA+ versus 50% in ASCA- CD patients (P = 0.03). This low proportion of smokers was more prominent in ASCA IgA+ patients than in isolated ASCA IgG+ patients (25.6% versus 45.5%) and was minimal in patients with high titers of ASCA IgA (0/8). Logistic regression showed smoking habit still borderline for significance (P = 0.057). Conclusions : Our results suggest a negative association between smoking and ASCA positivity in CD. This association was more prominent for ASCA IgA+. It indicates that smoking habit should be taken into account when analysing ASCA status in CD patients and may suggest an influence of smoking on immunization against intestinal material. [less ▲]

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See detailModulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice.
MASSION, Paul ULiege; Balligand, J.-L.

in Journal of Physiology (2003), 546(Pt 1), 63-75

The modulatory role of endothelial nitric oxide synthase (eNOS) on heart contraction, relaxation and rate is examined in light of recent studies using genetic deletion or overexpression in mice under ... [more ▼]

The modulatory role of endothelial nitric oxide synthase (eNOS) on heart contraction, relaxation and rate is examined in light of recent studies using genetic deletion or overexpression in mice under specific conditions. Unstressed eNOS-/- hearts in basal conditions exhibit a normal inotropic and lusitropic function, with either decreased or unchanged heart rate. Under stimulation with catecholamines, eNOS-/- mice predominantly show a potentiation in their beta-adrenergic inotropic and lusitropic responsiveness. A similar phenotype is observed in beta 3-adrenoceptor deficient mice, pointing to a key role of this receptor subtype for eNOS coupling. The effect of eNOS on the muscarinic cholinergic modulation of cardiac function probably operates in conjunction with other NO-independent mechanisms, the persistence of which may explain the apparent dispensability of this isoform for the effect of acetylcholine in some eNOS-/- mouse strains. eNOS-/- hearts submitted to short term ischaemia-reperfusion exhibit variable alterations in systolic and diastolic function and infarct size, while those submitted to myocardial infarction present a worsened ventricular remodelling, increased 1 month mortality and loss of benefit from ACE inhibitor or angiotensin II type I receptor antagonist therapy. Although non-conditional eNOS gene deletion may engender phenotypic adaptations (e.g. ventricular hypertrophy resulting from chronic hypertension, or upregulation of the other NOS isoforms) potentially confounding the interpretation of comparative studies, the use of eNOS-/- mice has undoubtedly advanced (and will probably continue to improve) our understanding of the complex role of eNOS (in conjunction with the other NOSs) in the regulation of cardiac function. The challenge is now to confirm the emerging paradigms in human cardiac physiology and hopefully translate them into therapy. [less ▲]

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See detailThe neuroendocrinology of reproductive behavior in Japanese quail
Balthazart, Jacques ULiege; Baillien, Michelle; Charlier, Thierry ULiege et al

in Domestic Animal Endocrinology (2003), 25

Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior ... [more ▼]

Sex steroid hormones such as testosterone have widespread effects on brain physiology and function but one of their best characterized effects arguably involves the activation of male sexual behavior. During the past 20 years we have investigated the testosterone control of male sexual behavior in an avian species, the Japanese quail (Coturnix japonica).We briefly reviewhere the main features and advantages of this species relating to the investigation of fundamental questions in the field of behavioral neuroendocrinology, a field that studies inter-relationship among hormones, brain and behavior. Special attention is given to the intracellular metabolism of testosterone, in particular its aromatization into an estrogen, which plays a critical limiting role in the mediation of the behavioral effects of testosterone. Brain aromatase activity is controlled by steroids which increase the transcription of the enzyme, but afferent inputs that affect the intraneuronal concentrations of calcium also appear to have a pronounced effect on the enzyme activity through rapid changes in its phosphorylation status. The physiological significance of these slowgenomic and rapid, presumably non-genomic, changes in brain aromatase activity are also briefly discussed. [less ▲]

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See detailLe complexe Chrysoperla carnea en Belgique (Neuroptera : Chrysopidae)
Bozsik, Andras; Mignon, Jacques ULiege; Gaspar, Charles

in Notes Fauniques de Gembloux (2003), 50

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à ... [more ▼]

De 1997 à 2002, près de 4000 Chrysoperla carnea sensu lato furent collectées dans quinze localités de Belgique, principalement dans la ville de Gembloux (Province de Namur). Le fauchage de la végétation à l’aide d’un filet représente le principal mode d’échantillonnage. Les individus capturés furent identifiés sur base des descriptions de Thierry et al. (1992), Duelli (1995, 1999 communication personnelle), ainsi que par comparaison, soit avec différents types morphologiques (de D. Thierry), soit à des individus identifiés sur base de leurs chants (par P. Duelli). Chrysoperla kolthoffi sensu Cloupeau (Ch.c.c.4. ou « motorboat » sensu Henry) constitue le taxon le plus représenté dans les différentes localités. Chrysoperla carnea sensu Cloupeau (« low motorboat » sensu Henry) est également souvent rencontrée abondamment, principalement en automne. Seule Chrysoperla lucasina Lacroix est observée plus rarement chaque année et dans chaque lieu. La fréquence saisonnière de Ch. carnea s.C. est variable. Ainsi, elle est relativement faible en été et elle augmente progressivement au cours de l’automne. A cette période, les proportions de Ch. kolthoffi diminuent tandis que le taux de Ch. lucasina reste stable. [less ▲]

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See detailAn Improved Method of Photometric Mode Identification: Applications to Slowly Pulsating B, beta Cephei, delta Scuti and gamma Doradus Stars
Dupret, Marc-Antoine ULiege; Scuflaire, Richard ULiege; Noels-Grötsch, Arlette ULiege et al

in Astrophysics & Space Science (2003), 284

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism ... [more ▼]

We present an improved version of the method of photometric mode identification based upon the inclusion of non-adiabatic eigenfunctions determined in the stellar atmosphere, according to the formalism recently proposed by Dupret et al. (2002). We apply our method to beta Cephei, Slowly Pulsating B, delta Scuti and gamma Doradus stars. Besides identifying the degree l of the pulsating stars, our method is also a tool for improving the knowledge of stellar interiors and atmospheres, by imposing constraints on the metallicity for beta Cephei and SPBs, the characteristics of the superficial convection zone for delta Scuti and gamma Doradus stars and the limb-darkening law. [less ▲]

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See detailDevelopment and validation of a specific radioimmunoassay for equine osteocalcin
Carstanjen, Bianca; Sulon, Joseph ULiege; Banga-Mboko, H. et al

in Domestic Animal Endocrinology (2003), 24(1), 31-41

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard ... [more ▼]

This study describes for the first time the development and validation of a sensitive and specific radioimmunoassay (RIA) for equine osteocalcin (OC) quantification using purified equine OC as standard, tracer, and immunogen for antibody formation in rabbits. The assay allowed to measure equine serum OC levels with a sensitivity of 0.2 ng/mL. Immunoreactive serum OC values of clinically normal, different-aged horses ranged from 3.68 to 127.31 ng/mL. Intra- and inter-assay coefficients of variation (CV) were 6.2 and 8.2%, respectively. Serial equine scrum sample dilutions were linear. The recovery of equine OC from equine serum samples ranged from 93.88 to 107.9%. There was a tight correlation between OC values measured with the equine- specific OC RIA and two commercially available bovine-specific OC RIA kits. However, highest serum OC values were obtained with the equine-specific OC RIA. In conclusion, our equine-specific OC RIA is sensitive, linear, accurate, precise, and reproducible. The assay allowed to quantify OC in equine serum samples and might, therefore, be used to monitor equine osteoblast activity associated with bone diseases, exercise, therapy forms or diet. [less ▲]

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See detailRelevance of bone mineral density, bone quality and falls in reduction of vertebral and non-vertebral fractures.
Hanssens, L.; Reginster, Jean-Yves ULiege

in Journal of musculoskeletal & neuronal interactions (2003), 3(3), 189-93

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the ... [more ▼]

All epidemiological studies conclude that without prompt, concerted and well-designed prevention programs, the increasing cost related to osteoporotic fractures will become an unbearable burden for the community within the next fifteen years. However, the most effective way of setting up such preventive strategies is not yet unequivocally defined. Low bone mass and microarchitectural damage of bone tissue may account for a large part of the epidemiology of vertebral fractures. Extraskeletal determinants, including low muscle strength, poor balance and gait, all resulting in an increased propensity to fall, also play a major role in the occurrence of hip fracture. Depending on the localization of the fractures, the relative importance of skeletal and extraskeletal risk factors can significantly differ. For prevention of vertebral fractures, drugs affecting bone mass and skeletal architecture may provide a substantial benefit while hip fracture prevention will be more successfully targeted by multi-faceted strategies concentrating not only on the skeletal dimension of the fracture but also aiming, either pharmacologically or through multi-intervention programs, at a reduction in the incidence and in the consequences of falls in the elderly. [less ▲]

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See detailLe passé récent, la réforme de l'impôt des personnes physiques, le cas des villes
Jurion, Bernard ULiege

in Bulletin de Documentation du Ministère des Finances (2003)

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See detail"Reprise" et "Charbons ardents" - la mémoire et la lutte
Servais, Christine ULiege

in Cinémaction (2003), 110

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See detailIncidental control of rosacea by somatostatin.
Pierard, Claudine ULiege; Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Dermatology : International Journal for Clinical & Investigative Dermatology (2003), 206(3), 249-51

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings ... [more ▼]

BACKGROUND: The precise pathomechanism of rosacea remains elusive. The disease commonly requires long-term treatments using topical or oral therapies. OBJECTIVE: This report presents incidental findings about the possible modulatory role of somatostatin in the outcome of rosacea. METHOD: Four patients presenting long-standing recalcitrant facial rosacea were treated with octreotide for diabetic retinopathy. RESULTS: Rosacea improved rapidly and even cleared without any recurrence in 3 of the patients. CONCLUSION: The beneficial effect might be attributed to inhibitory actions on the sebaceous gland, the neovascularization and/or on the inflammatory process. [less ▲]

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See detailMediolatinitas : légendes hagiographiques et statistique linguistique
Philippart de Foy, Caroline ULiege

in Hagiographica : Rivista di Agiografia e Biografia della Società Internazionale per lo Studio del Medioevo Latino (2003), X

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See detailSeismic triggering of landslides. Part B: Simulation of dynamic failure processes
Havenith, Hans-Balder ULiege; Strom, A.; Calvetti, F. et al

in Natural Hazards & Earth System Sciences (2003), 3

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on ... [more ▼]

From field observations it is possible to establish correlations between geological conditions and landslide occurrence. However, in general, it is difficult to assess the affect of individual factors on slope instability because of their mutual interaction. In addition, the dynamic effect of propagating seismic waves significantly increases the complexity of the slope stability problem. Wave diffraction, reflection and focusing effects are dependent on local geological conditions and make it difficult to analyse dynamic sliding mechanisms using field observations alone. As a consequence, in order to examine the influence of various geological and seismic factors on slope movements, it is often necessary to produce numerical models. This paper describes the results of such models as applied to two case studies in Kyrgyzstan: the Ananevo rockslide, located in granite, and the Suusamyr debris slump-flow, situated within soft sediments (see Part A: Havenith et al., 2003). Discrete element modelling (UDEC), adapted both to the discontinuous character of fractured rock and to the heterogeneity of layered mediums, was used. This permitted simulation of deformation mechanisms, including seismically induced bending, block tilting, and slip. Particular attention was paid to the interaction between deformation mechanisms, site-specific amplification effects, and subsurface structure. [less ▲]

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See detailCompte rendu d’Adrienne et Luc Fontainas, et Émile Van Balberghe, Publications de la Librairie Deman. Bibliographie
Durand, Pascal ULiege

in Textyles : Revue des Lettres Belges de Langue Française (2003)

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See detailInorganic and organic carbon biogeochemistry in the Gautami Godavari estuary (Andhra Pradesh, India) during pre-monsoon : the local impact of extensive mangrove forests
Bouillon, Steven; Frankignoulle, Michel; Dehairs, Frank et al

in Global Biogeochemical Cycles (2003), 17(4),

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the ... [more ▼]

[1] The distribution and sources of organic and inorganic carbon were studied in the Gautami Godavari estuary (Andhra Pradesh, India) and in a mangrove ecosystem in its delta during pre-monsoon. In the oligohaline and mesohaline section (salinity 0–15) of the estuary, internal production of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) was recorded, and the d13CDIC profile suggests that carbonate dissolution may be an important process determining the DIC dynamics in this section of the Godavari. The partial pressure of CO2 (pCO2) was fairly low along the entire salinity gradient, (293–500 ppm), but much higher and more variable (1375–6437 ppm) in the network of tidal mangrove creeks in the delta. Here, variations in the concentration and d13C of the DIC pool were shown to result largely from the mineralization of organic matter. The present study clearly identifies the mangrove creeks as an active site of mineralization and CO2 efflux to the atmosphere, but shows that these changes in the aquatic biogeochemistry are a localized feature, rapidly fading in the adjacent Kakinada Bay. Our data indicate that mineralization of dissolved organic carbon (DOC) of mangrove origin, and its subsequent efflux as CO2 to the atmosphere may represent an important fate for mangrove carbon. Although further quantification of this process in a variety of systems is required, we suggest that some of the current ideas on the role of mangroves in the carbon budget of the coastal zone may need to be reconsidered. [less ▲]

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See detailPrimary intraventricular brain abscess.
Lambo, A.; NCHIMI LONGANG, Alain ULiege; Khamis, J. et al

in Neuroradiology (2003), 45(12), 908-10

We report a primary intraventricular brain abscess in a 13-year-old boy. We discuss possible explanations for this rare occurrence.

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See detailFronts and mesoscale variability in the southern Indian Ocean as inferred from the TOPEX/POSEIDON and ERS-2 altimetry data
Kostianoy, Andrey G.; Ginzburg, Anna I.; Lebedev, Sergey Anatolievich et al

in Oceanology (2003), 43(5, SEP-OCT), 632-642

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed ... [more ▼]

Charts of sea level anomalies (SLA) based on the combined altimetry data from the TOPEX/POSEIDON and ERS-2 satellites, as well as the corresponding charts of the sea surface dynamic heights (constructed by the superposition of SLA distributions over the climatic dynamic topography) and the temperature gradients at the ocean surface on the basis of the satellite Multi-Channel Sea Surface Temperature (MCSST) data, were used to study the mesoscale variability related to the fronts in the Southern Indian Ocean (30degrees-60degrees S, 20degrees-150degrees E). An analysis of these three types of satellite information for the central weeks of each month during the period from 1997 to 1999 allowed us to distinguish zones of enhanced meandering (eddy formation) within the basin under study, as well as the contributions of individual fronts and their interaction to the regional mesoscale variability. The problems of the correlation between the intensity of mesoscale variability and peculiarities of the local bottom topography and seasonal/interannual variability of mesoscale dynamics are addressed. [less ▲]

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See detailPregnancy-associated glycoprotein concentrations during pregnancy and the postpartum period in Azawak Zebu cattle
Melo de Sousa, Noelita ULiege; Zongo, M.; Pitala, W. et al

in Theriogenology (2003), 59(5-6), 1131-1142

Specific RIA systems were developed and used to measure pregnancy-associated glycoprotein (PAG) concentrations during gestation and the postpartum period in Azawak Zebu cows. Twelve females were palpated ... [more ▼]

Specific RIA systems were developed and used to measure pregnancy-associated glycoprotein (PAG) concentrations during gestation and the postpartum period in Azawak Zebu cows. Twelve females were palpated per rectum and diagnosed as pregnant. Blood samples were taken at 5-10-day intervals from approximately Week 8 of gestation until Week 10 postpartum (pp). One Zebu cow (Z15) initially diagnosed as pregnant showed PAG concentrations lower than the assay sensitivity (<0.20 ng/ml) and did not calve. Another cow (ZSand) showed abnormally high PAG concentrations during gestation and was excluded from the general PAG profile. The 10 other Zebu cows exhibited a very similar PAG profile. In these animals, concentrations increased progressively from Week 8 to 35 of gestation (from 6.0 +/- 4.2 to 196.0 +/- 34.8 ng/ml), remaining relatively constant until Week 39 (210.8 +/- 74.8 ng/ml), when they increased sharply to reach their highest level (1095.6 +/- 607.2 ng/ml) at around parturition. After delivery, PAG concentrations declined significantly (P < 0.05) until Week 2 postpartum (348.4 +/- 85.6 ng/ml) and slowly until Week 10 postpartum. Our results revealed that the PAG pattern in Zebu cattle was similar to those of taurine breeds during the first two trimesters of pregnancy, but differed in the peripartum period. [less ▲]

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See detailUn monde de rejetés
Dumortier, Jean-Louis ULiege

in Traces (2003), 14

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See detailEquine trypsin: purification and development of a radio-immunoassay
Grulke, Sigrid ULiege; Deby-Dupont, G.; Gangl, M. et al

in Veterinary Research (2003), 34(3, May-Jun), 317-330

Shock is accompanied by generalised splanchnic hypoperfusion, and splanchnic organs like the pancreas can be damaged, as shown in animal experimental models and in humans, by the presence of high plasma ... [more ▼]

Shock is accompanied by generalised splanchnic hypoperfusion, and splanchnic organs like the pancreas can be damaged, as shown in animal experimental models and in humans, by the presence of high plasma concentrations of trypsin and other pancreatic enzymes. In order to design a radioimmunoassay technique (RIA) for the measurement of equine trypsin-like immunoreactivity (TLI) in biological fluids, trypsin was purified (with purity greater than or equal to 96 %) from the equine pancreas by extraction in an acid medium, ammonium sulfate precipitations, gel filtration chromatography and, after activation of trypsinogen into trypsin, affinity chromatography. Gel polyacrylamide electrophoresis showed a monomeric enzyme with a molecular weight of 27 kDa. The purified equine trypsin served for the immunisation of rabbits in order to obtain a specific antiserum, and the labelled antigen was prepared by iodination of equine trypsin with I-125. The RIA was based on the binding of the antigen to the antibody followed by the separation of the antigen-antibody complex by immunoprecipitation in the presence of sheep anti-rabbit gammaglobulins and the assay of the radioactivity in the precipitate. The RIA showed good sensitivity, specificity, precision, accuracy and reproducibility. The reference mean value of TLI in the plasma of healthy horses (n = 20) was 30.01 +/- 6.84 ng/mL (upper confidence limit 50.52 ng/mL; p < 0.01). Three horses with non strangulating intestinal obstruction without shock showed TLI values within normal limits whereas 5 of 7 horses with strangulation obstruction showed TLI levels above the upper confidence limit. Further studies using the RIA and the enzymatic assay should be performed in order to confirm the role of the pancreas in equine intestinal obstruction. [less ▲]

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See detailL'application dans le temps de la peine de travail
Jacobs, Ann ULiege

in Revue de Droit Pénal et de Criminologie (2003)

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See detailThe role of reactive oxygen species in homeostasis and degradation of cartilage.
Henrotin, Yves ULiege; Bruckner, P.; Pujol, J. P.

in Osteoarthritis and Cartilage (2003), 11(10), 747-55

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and ... [more ▼]

OBJECTIVES: The metabolism of cells in articular joint tissues in normal and pathological conditions is subject to a complex environmental control. In addition to soluble mediators such as cytokines and growth factors, as well as mechanical stimuli, reactive oxygen species (ROS) emerge as major factors in this regulation. ROS production has been found to increase in joint diseases, such as osteoarthritis and rheumatoid arthritis, but their role in joint diseases initiation and progression remains questionable. METHOD: This review is focused on the role of ROS, mainly nitric oxide, peroxynitrite and superoxide anion radicals, in the signaling mechanisms implied in the main cellular functions, including synthesis and degradation of matrix components. The direct effects of ROS on cartilage matrix components as well as their inflammatory and immunomodulatory effects are also considered. RESULTS: Some intracellular signaling pathways are redox sensitive and ROS are involved in the regulation of the production of some biochemical factors involved in cartilage degradation and joint inflammation. Further, ROS may cause damage to all matrix components, either by a direct attack or indirectly by reducing matrix components synthesis, by inducing apoptosis or by activating latent metalloproteinases. Finally, we have highlighted the uncoupling effect of ROS on tissue remodeling and synovium inflammation, suggesting that antioxidant therapy could be helpful to treat structural changes but not to relieve symptoms. CONCLUSIONS: This review of the literature supports the concept that ROS are not only deleterious agents involved in cartilage degradation, but that they also act as integral factors of intracellular signaling mechanisms. Further investigation is required to support the concept of antioxidant therapy in the management of joint diseases. [less ▲]

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See detailCytokinin levels in leaves, leaf exudate and shoot apical meristem of Arabidopsis thaliana during floral transition
Corbesier, Laurent; Prinsen, Els; Jacqmard, Annie ULiege et al

in Journal of Experimental Botany (2003), 54(392), 2511-2517

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis ... [more ▼]

Understanding the complete picture of floral transition is still impaired by the fact that physiological studies mainly concern plant species whose genetics is poorly known, and vice versa. Arabidopsis thaliana has been successfully used to unravel signalling pathways by genetic and molecular approaches, but analyses are still required to determine the physiological signals involved in the control of floral transition. In this work, the putative role of cytokinins was investigated using vegetative plants of Arabidopsis (Columbia) induced to flower synchronously by a single 22 h long day. Cytokinins were analysed in leaf extracts, leaf phloem exudate and in the shoot apical meristem at different times during floral transition. It was found that, in both the leaf tissues and leaf exudate, isopentenyladenine forms of cytokinins increased from 16 h after the start of the long day. At 30 h, the shoot apical meristem of induced plants contained more isopentenyladenine and zeatin than vegetative controls. These cytokinin increases correlate well with the early events of floral transition. [less ▲]

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See detailCharacterisation of different inulin samples by DSC - Influence of polymerisation degree on melting temperature
Blecker, Christophe ULiege; Chevalier, J. P.; Fougnies, C. et al

in Journal of Thermal Analysis & Calorimetry (2003), 71(1), 215-224

Melting behaviour of powder inulin has been studied by differential scanning calorimetry. DSC curves show two endothermic peaks, relative to water elimination and to inulin melting, respectively. The ... [more ▼]

Melting behaviour of powder inulin has been studied by differential scanning calorimetry. DSC curves show two endothermic peaks, relative to water elimination and to inulin melting, respectively. The second peak is dependent on inulin type and a shift to a higher temperature is observed with increasing average polymerisation degree (DP) of the sample. For similar crystallinity index, linear relations have been underlined and so predicting inulin mean DP can be done by DSC analysis. The study shows that a relatively high heating rate (25degreesC min(-1)) can be used and brings a supplementary interest by an important reduction of analysis time. [less ▲]

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See detailComment j'explore ... un trouble de la magnésémie
Boman, Xavier ULiege; Guillaume, Thierry; Krzesinski, Jean-Marie ULiege

in Revue Médicale de Liège (2003), 58(2), 104-108

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical ... [more ▼]

Magnesium (Mg) therapy is often proposed against stress and to correct asthenia. Thus our aim has been to review the role of Mg, the mechanisms of its homeostasis before detailing the clinical presentations and etiologies of hypo- and hypermagnesemia and their exploration. Hypomagnesemia frequently occurs but is clinically rarely recognized without biological serum ionic determinations because causing atypical signs miming those of other ion deficiencies. Hypermagnesemia is uncommon but often occurs in the presence of renal insufficiency especially with excess of Mg administration. [less ▲]

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See detailWavelet denoising of Poisson-distributed data and applications.
Charles, Catherine ULiege; Rasson, Jean-Paul

in Computational Statistics & Data Analysis (2003), 43

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See detailEffets fonctionnels respiratoires induits par l'inhalation de glycopyrrolate chez le cheval poussif en crise
Art, Tatiana ULiege; de Moffarts, Brieuc; Van Erck, Emmanuelle et al

in Annales de Médecine Vétérinaire (2003), 147

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently ... [more ▼]

Bronchoconstriction is one of the most constant clinical sign observed in heaves-affected horses in crisis. Cholinergic pathways are involved in the occurrence of this obstruction. Consequently anticholinergic drugs are potentially able to improve the pulmonary function of horses in acute crisis. Among these, atropine and ipratropium bromide have been previously experimented and their beneficial effects reported. In the present work, glycopyrrolate, another synthetic anticholinergic molecule has been tested for bronchodilator efficiency in heaves-affected horses. An acute exacerbation of the illness was obtained by a natural challenge with hay and straw in 7 heaves-affected horses. The first day, the reversibility of the bronchospasm of these horses was controlled by intravenous administration of atropine. Then, pulmonary function tests including mechanics of breathing, ie measurement of pleural pressure changes and respiratory airflows, and arterial blond gases analysis, were performed before as well as 15 and 60 minutes alter inhalation of 1500 µg of glycopyrrolate (Robinul®). The crisis induced a dramatic increase of total pulmonary resistance and maximal pleural pressure changes as well as a decrease in dynamic lung compliance. These changes were significantly reversed 15 and 60 minutes after inhalation of glycopyrrolate. We did not observe any adverse effects similar to those classically observed with atropine. These results showed that glycopyrrolate is a very efficient bronchodilator that may be used by the practitioner to treat a heaves-affected horses in crisis [less ▲]

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See detailLa problématique de la résistance des pneumocoques aux antibiotiques
Marchal, Valérie; Melin, Pierrette ULiege; Hayette, Marie-Pierre ULiege et al

in Revue Médicale de Liège (2003), 58(11), 675-680

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to ... [more ▼]

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia and it is also a common cause of sinusitis, otitis media, bacteremia and meningitis. The increasing resistance to antimicrobial agents, now endemic in many countries, reflects an uncontrolled use of antibiotics. A good antibiotics policy and vaccination are at the moment the only way to control efficaciously the increasing antibiotic resistance of Streptococcus pneumoniae [less ▲]

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See detailQuantitative dynamics of PCB transfer from mother to pup during lactation in UK grey seals Halichoerus grypus
Debier, Cathy; Pomeroy, Paddy P.; Dupont, Cédric et al

in Marine Ecology-Progress Series (2003), 247

PCB contamination was measured in the milk and serum of grey seal Halichoerus grypus mothers and in the serum of their pups sampled from 2 to 5 times between parturition and weaning on the Isle of May ... [more ▼]

PCB contamination was measured in the milk and serum of grey seal Halichoerus grypus mothers and in the serum of their pups sampled from 2 to 5 times between parturition and weaning on the Isle of May, Scotland, in 1998 and 2000. Blubber biopsies were also taken from the lactating females at early and late lactation in 2000. Concentrations of PCBs in milk stayed constant during the first part of lactation (0.31 +/- 0.17 mug g milk(-1)) and then increased at late lactation (0.67 +/- 0.42 mug g milk(-1)). Curiously, it did not follow the changes of milk lipid content, which increased at early lactation and then stayed constant until the end of the nursing period. As a result, even when expressed per unit of milk lipids, PCBs underwent a rise at the end of lactation. The changes in milk PCBs were accompanied by similar dynamics in maternal serum as well as in pup serum. Increased concentrations of PCBs at late lactation in serum and milk may be explained in part by the changes observed in maternal blubber. PCB levels increased significantly between early and late lactation in inner blubber, suggesting that PCBs are less easily mobilised from blubber than lipids. At late lactation, the retention capacity of the reduced blubber layer for PCBs might have reached its maximum. The mobilization of less polar lipids from blubber might also occur at this stage. In both cases, this could result in a higher mobilization of PCBs at this time. While inner blubber was significantly less concentrated than outer blubber at early lactation (1.26 +/- 0.72 mug g lipids(-1) in inner blubber vs 3.16 +/- 1.34 mug g lipids(-1) in outer blubber), these variations disappeared at late lactation (3.24 +/- 2.60 mug g lipids(-1) in inner blubber vs 3.59 +/- 1.46 mug g(-1) lipids in outer blubber). Newborn pups already had significantly higher serum levels of PCBs than their mothers, revealing an important placental transfer (11.9 +/- 7.0 ng ml serum(-1) in pups vs 6.7 +/- 3.5 ng ml serum(-1) in mothers). These differences were even greater in late lactation, due to the ingestion of milk (27.9 +/- 18.1 ng ml serum(-1) in pups vs 12.2 +/- 7.2 ng ml serum(-1) in mothers). As lactation progressed, PCB levels in pup serum increased exponentially as compared to the levels in the serum of their mothers. [less ▲]

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See detailNumerus clausus en fin de troisieme candidature en medecine: mort annoncee d'une heresie?
Rabenda, Véronique ULiege; Boniver, Jacques ULiege; Reginster, Jean-Yves ULiege

in Revue Médicale de Liège (2003), 58(7-8, Jul-Aug), 508-14

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical ... [more ▼]

Owing to the establishment of a procedure aiming at a reduction of the medical supply (numerus clausus), the French Community of Belgium had decided to introduce, at the end of the third year of medical studies (third candidature), a procedure of selective attribution of the certificate allowing for a unlimited medical practice. We assessed the predictive value of the results obtained during and at the end of the first candidature (first year of medicine) for the attribution of this certificate. We studied the results of the 225 students enrolled in the first candidature in medicine at the University of Liege during the academic year 1997-1998, and we correlated them to the subsequent attribution (1999-2000- and 2000-2001) of the certificate. The success of the first candidature in the first or second session is an important predicting factor towards the reception of the certificate. A non-authorization to continue the studies in medicine in case of failure in the first session or a non-authorization to repeat the first candidature in case of failure in the second session would have, respectively, a negative predictive value (NPV) of 91.9% and 97.4% and would allow to restream 111 students at the end of the first session or 39 students at the end of the first candidature. The results of the preliminary assessments mode during the month of January are also highly predictive of the chances to get the certificate. Among the 160 students who have not successfully passed a minimum of 3 exams, only 14 students obtained the certificate. The restreaming of those students would correspond to a NPV of 91.2%. Students who were not successful in a minimum of 2 exams would have less than 5% chance to obtain the certificate. In this case, 109 students would be restreamed (NPV = 95.4%). In conclusion, the selection of the students who will obtain, at the end of the third year of medicine, the certificate allowing them for an unlimited medical practice is obtained, in a large proportion, during the first candidature and especially after the session of January. In view of those results and considering the decree abolishing the selection at the end of the third year of medical studies, one could argue about the appropriateness of the current procedure, chosen by the French Community of Belgium, compared to other solutions prioritising an earlier selection of the future doctors. [less ▲]

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See detailT-cell reconstitution after unmanipulated, CD8-depleted or CD34-selected nonmyeloablative peripheral blood stem-cell transplantation.
Baron, Frédéric ULiege; Schaaf-Lafontaine, Nicole ULiege; Humblet-Baron, Stéphanie ULiege et al

in Transplantation (2003), 76(12), 1705-13

BACKGROUND: We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem ... [more ▼]

BACKGROUND: We have previously shown that CD8 depletion or CD34 selection of peripheral blood stem cells (PBSC) reduced the incidence of acute graft-versus-host disease (GvHD) after nonmyeloablative stem-cell transplantation (NMSCT). In this study, we analyze the effect of CD8 depletion or CD34 selection of the graft on early T-cell reconstitution. METHODS: Nonmyeloablative conditioning regimen consisted in 2 Gy total-body irradiation (TBI) alone, 2 Gy TBI and fludarabine, or cyclophosphamide and fludarabine. Patients 1 to 18 received unmanipulated PBSC, patients 19 to 29 CD8-depleted PBSC, and patients 30 to 35 CD34-selected PBSC. RESULTS: T-cell counts, and particularly CD4+ and CD4CD45RA+ counts, remained low the first 6 months after nonmyeloablative stem-cell transplantation (NMSCT) in all patients. CD34 selection (P<0.0001) but not CD8 depletion of PBSC significantly decreased T-cell chimerism. Donor T-cell count was similar in unmanipulated compared with CD8-depleted PBSC recipients but was significantly lower in CD34-selected PBSC recipients (P=0.0012). T cells of recipient origin remained stable over time in unmanipulated and CD8-depleted PBSC patients but expanded in some CD34-selected PBSC recipients between day 28 and 100 after transplant. Moreover, whereas CD8 depletion only decreased CD8+ counts (P<0.047), CD34 selection reduced CD3+(P<0.001), CD8+(P<0.016), CD4+ (P<0.001), and CD4+CD45RA+ (P<0.001) cell counts. T-cell repertoire was restricted in all patients on day 100 after hematopoietic stem-cell transplantation but was even more limited after CD34 selection (P=0.002). CONCLUSIONS: Despite of the persistence of a significant number of T cells of recipient origin, T-cell counts were low the first 6 months after NMSCT. Moreover, contrary with CD8 depletion of the graft that only affects CD8+ lymphocyte counts, CD34 selection dramatically decreased both CD8 and CD4 counts. [less ▲]

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See detailRecent developments in 5-lipoxygenase inhibitors
Julémont, F.; Dogné, J.-M.; Laeckmann, D. et al

in Expert Opinion on Therapeutic Patents (2003), 13

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See detailLa motivation du refus de prononcer une peine de travail
Jacobs, Ann ULiege

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2003)

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See detailLarge phosphorus hyperfine coupling as a sensitive tool for studying molecular dynamics : ESR and Molecular Mechanics studies of ring interconversion in cis-2,5-diphosphoryl-2,5-dimethyl-pyrrolidinoxyl radical
Rockenbauer, Antal; Gaudel-Siri, Anouk; Siri, Didier et al

in Journal of Physical Chemistry A (2003), 107(19), 3851-3857

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was ... [more ▼]

ESR spectra of cis- and trans-â-diphosphorylated pyrrolidine-N-oxyl radicals, c-1 and t-1, were studied in liquid and frozen solution. The expected 1:2:1 triplet (aP (2)) of the 1:1:1 triplet (aN) was observed for t-1; however, for c-1, the inner lines of the 1:2:1 triplet showed a dramatic broadening characteristic of chemical exchange between two equivalent conformations. Owing to the large difference in the hyperfine splitting constants (hfsc) of the exchanging phosphorus (¢aP 21 G), the coalescence temperature was unusually high (193 K, in n-pentane), and the potential barrier for ring interconversion (10.5 kJ mol-1) was easily obtained from the temperature dependence of the exchange rate. This value was in very good agreement with the value obtained for an empirical pseudorotational potential (11 kJ mol-1) that was adjusted to fit the temperature dependence of the phosphorus hfsc. For c-1, molecular mechanics calculations gave similar characteristics for the pseudorotational potential and indicated the existence of two identical minima with distorted geometries lying between 3T4 and 3E or 4T3 and E3. For t-1, only the 3T4 conformer was found to be significantly populated. Frozen solution spectra showed that the phosphorus hfsc anisotropy is higher when the C-P bond is pseudoaxial; this result can be explained by a geometry-dependent delocalization of the unpaired electron into the phosphorus 3p orbitals. [less ▲]

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See detailThe inhibitor thiomandelic acid binds to both metal ions in metallo-beta-lactamase and induces positive cooperativity in metal binding.
Damblon, Christian ULiege; Jensen, Mikael; Ababou, Abdessamad et al

in Journal of Biological Chemistry (2003), 278(31), 29240-51

Thiomandelic acid is a simple, broad spectrum, and reasonably potent inhibitor of metallo-beta-lactamases, enzymes that mediate resistance to beta-lactam antibiotics. We report studies by NMR and ... [more ▼]

Thiomandelic acid is a simple, broad spectrum, and reasonably potent inhibitor of metallo-beta-lactamases, enzymes that mediate resistance to beta-lactam antibiotics. We report studies by NMR and perturbed angular correlation (PAC) spectroscopy of the mode of binding of the R and S enantiomers of thiomandelic acid, focusing on their interaction with the two metal ions in cadmium-substituted Bacillus cereus metallo-beta-lactamase. The 113Cd resonances are specifically assigned to the metals in the two individual sites on the protein by using 113Cd-edited 1H NMR spectra. Each enantiomer of thiomandelate produces large downfield shifts of both 113Cd resonances and changes in the PAC spectra, which indicate that they bind such that the thiol of the inhibitor bridges between the two metals. For R-thiomandelate, this is unambiguously confirmed by the observation of scalar coupling between Halpha of the inhibitor and both cadmium ions. The NMR and PAC spectra reveal that the two chiral forms of the inhibitor differ in the details of their coordination geometry. The complex with R-thiomandelate, but not that with the S-enantiomer, shows evidence in the PAC spectra of a dynamic process in the nanosecond time regime, the possible nature of which is discussed. The thiomandelate complex of the mononuclear enzyme can be detected only at low metal to enzyme stoichiometry; the relative populations of mononuclear and binuclear enzyme as a function of cadmium concentration provide clear evidence for positive cooperativity in metal ion binding in the presence of the inhibitor, in contrast to the negative cooperativity observed in the free enzyme. [less ▲]

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See detailClassification des rongeurs
Mignon, Jacques ULiege; Hardouin, Jacques

in Bulletin BEDIM (2003), 12(1), 12-13

The note aims at providing the main characteristics of the principal families of rodents relevant to minilivestock.

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See detailDesign and methodology of the phase 3 trials for the clinical development of strontium ranelate in the treatment of women with postmenopausal osteoporosis
Meunier, P. J.; Reginster, Jean-Yves ULiege

in Osteoporosis International (2003), 14(Suppl. 3), 66-76

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This ... [more ▼]

The phase 3 program for strontium ranelate, a new oral agent in the treatment of women with postmenopausal osteoporosis, was aimed to assess the efficacy and safety of the daily oral dose of 2 g. This program was conducted in 12 countries, involved 75 centers, and was structured in 3 studies: FIRST (Fracture International Run-in for Strontium ranelate Trial), SOTI (Spinal Osteoporosis Therapeutic Intervention study) and TROPOS (TReatment Of Peripheral OSteoporosis). FIRST, a run-in open study, was designed to start the normalization of the calcium and vitamin D status of the patients, check all entry criteria, and ensure inclusion of a sufficient number of well-motivated patients in either one of the two therapeutic intervention protocols, SOTI or TROPOS: FIRST included 9,196 patients. SOTI and TROPOS were prospective, randomized, double-blind clinical trials comparing, in two parallel groups, the daily oral dose of 2 g of strontium ranelate with placebo, the patients of both groups receiving calcium and vitamin D according to their own deficiencies. The main objective of SOTI and TROPOS was to demonstrate a reduction in the incidence of postmenopausal women experiencing a new osteoporotic fracture (vertebral fracture in SOTI and nonvertebral fracture in TROPOS) over a 3-year treatment period, the total duration of the studies being 5 years. SOTI included 1,649 women with at least one osteoporotic vertebral fracture at inclusion and a lumbar BMD less than or equal to 0.840 g/cm(2). TROPOS included 5,091 women with a femoral neck BMD less than or equal to 0.600 g/cm(2). The phase 3 program for the clinical development of strontium ranelate in women with postmenopausal osteoporosis is a long-term program with the main statistical analysis after 3 years of treatment. Its aim is to demonstrate the effect of strontium ranelate on the axial and appendicular skeleton as well as its tolerability in osteoporotic patients with replete calcium and vitamin D stores. [less ▲]

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See detailIdentités et valeurs politiques : quelle homogénéité pour l'Eurégio ?
Jacquemain, Marc ULiege

in Fédéralisme - Régionalisme (2003)

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and ... [more ▼]

Euregio Mosa-Rhine is a euregional structure that agregates Province of Liege and German-speaking belgian community (Belgium) Province of Limburg (Belgium), Province of South-Limburg (Netherlands) and Regio Aachen (Germany). It is supposed to be an area with many commercial and cultural inter-relations. Throuth a survey led in 2002, the paper tries to assess cultural similitaries and differences between the five components at the level of social identity and political values. It shows a contrasted landscape where the two dutch-speaking parts being more individualist, the german part being more comunitarian and, at the heart, the province of Liege more materialist and egalitarian. [less ▲]

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See detailPour lire Pédigrée
Dumortier, Jean-Louis ULiege

in Dossiers L (Littérature française de Belgique (2003), 64(4),

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